Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
COL3A1	1281	broad.mit.edu	37	2	189872774	189872774	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr2:189872774C>G	ENST00000304636.3	+	47	3601	c.3431C>G	c.(3430-3432)cCc>cGc	p.P1144R	COL3A1_ENST00000317840.5_Intron	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1144	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	CCTGTTGGACCCAGTGGACCT	0.473000													10	34					0	0	1	0	0
UTP14C	9724	broad.mit.edu	37	13	52603228	52603228	+	Silent	SNP	A	A	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr13:52603228A>T	ENST00000521776.2	+	2	1021	c.288A>T	c.(286-288)tcA>tcT	p.S96S	ALG11_ENST00000523764.1_3'UTR|ALG11_ENST00000521508.1_3'UTR	NM_021645.5	NP_067677.4	Q5TAP6	UT14C_HUMAN	UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)	96					cell differentiation|meiosis|multicellular organismal development|rRNA processing|spermatogenesis	nucleolus|small-subunit processome				breast(4)|cervix(1)|endometrium(1)|large_intestine(10)|lung(10)|ovary(3)|skin(1)|stomach(1)|urinary_tract(1)	32		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.3e-08)		TTAAAACTTCATCTTCTTTGG	0.428000													34	180					0	0	1	0	0
AHSG	197	broad.mit.edu	37	3	186334993	186334993	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr3:186334993C>A	ENST00000411641.2	+	4	646	c.427C>A	c.(427-429)Cgc>Agc	p.R143S	AHSG_ENST00000273784.5_Missense_Mutation_p.R144S			P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	143					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(2)|stomach(1)	22	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		CGAGGACGTGCGCAAGGTGTG	0.642000											OREG0015968	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	96					3.83957e-06	4.18086e-06	1	1	0
RNF17	56163	broad.mit.edu	37	13	25424514	25424514	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr13:25424514C>T	ENST00000255324.5	+	23	3189	c.3137C>T	c.(3136-3138)gCt>gTt	p.A1046V	RNF17_ENST00000339524.3_Missense_Mutation_p.A98V|RNF17_ENST00000381921.1_Missense_Mutation_p.A1046V	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1046					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		ACAGCAACAGCTTGTGACTGT	0.383000													10	32					0	0	1	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18829843	18829843	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr9:18829843C>T	ENST00000380548.4	+	23	4456	c.4117C>T	c.(4117-4119)Ccc>Tcc	p.P1373S	ADAMTSL1_ENST00000380545.5_Missense_Mutation_p.P74S	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1373						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		TCTCACAGATCCCCCCCAAGT	0.567000													12	40					0	0	1	0	0
HS3ST2	9956	broad.mit.edu	37	16	22826294	22826294	+	Silent	SNP	C	C	A	rs140526711		TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr16:22826294C>A	ENST00000261374.3	+	1	797	c.363C>A	c.(361-363)ggC>ggA	p.G121G		NM_006043.1	NP_006034.1	Q9Y278	HS3S2_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 2	121						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 2 activity			breast(2)|kidney(1)|large_intestine(5)|liver(2)|lung(5)|ovary(1)|pancreas(2)|skin(1)	19				GBM - Glioblastoma multiforme(48;0.0299)		TCATTGTGGGCGTGAAGAAGG	0.677000													10	10					0.0692343	0.0706767	1	1	0
GRIN2B	2904	broad.mit.edu	37	12	13716136	13716136	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr12:13716136C>T	ENST00000279593.3	-	13	4245	c.4036G>A	c.(4036-4038)Gag>Aag	p.E1346K		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1346					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AAGGTGCTCTCGCCAGCTGAC	0.612000													8	80					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12315474	12315474	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:12315474G>A	ENST00000256186.2	+	3	787	c.496G>A	c.(496-498)Gag>Aag	p.E166K		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	166					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		GAAGGAAGAAGAGGGAGGGCC	0.552000													23	62					0	0	1	0	0
TLN2	83660	broad.mit.edu	37	15	63014669	63014669	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr15:63014669C>T	ENST00000561311.1	+	25	3339	c.3109C>T	c.(3109-3111)Cgt>Tgt	p.R1037C	TLN2_ENST00000306829.6_Missense_Mutation_p.R1037C			Q9Y4G6	TLN2_HUMAN	talin 2	1037	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			NS(3)|breast(6)|central_nervous_system(3)|endometrium(8)|kidney(8)|large_intestine(20)|lung(34)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)	99						GGCGGAGCTGCGTACCGCCTC	0.632000													5	27					0	0	1	0	0
ANKRD32	84250	broad.mit.edu	37	5	94030836	94030836	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr5:94030836C>A	ENST00000265140.5	+	21	3415	c.2996C>A	c.(2995-2997)aCc>aAc	p.T999N	ANKRD32_ENST00000493934.1_Intron	NM_032290.3	NP_115666.2	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	999										NS(1)|breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(2)|prostate(1)|skin(1)	13		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		CATAAAGAAACCACCAGTGTT	0.348000													12	90					4.35082e-09	5.07595e-09	1	1	0
LSM10	84967	broad.mit.edu	37	1	36859702	36859702	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:36859702C>T	ENST00000315732.2	-	2	178	c.29G>A	c.(28-30)cGg>cAg	p.R10Q	LSM10_ENST00000476041.1_5'UTR	NM_032881.1	NP_116270.1	Q969L4	LSM10_HUMAN	LSM10, U7 small nuclear RNA associated	10					histone mRNA metabolic process|mRNA processing|RNA splicing|S phase of mitotic cell cycle|termination of RNA polymerase II transcription	Cajal body|U7 snRNP	histone pre-mRNA DCP binding|protein binding			upper_aerodigestive_tract(1)|urinary_tract(1)	2		Myeloproliferative disorder(586;0.0393)				AGAGATGGTCCGCTCCTTCAC	0.602000													12	48					0	0	1	0	0
MET	4233	broad.mit.edu	37	7	116339760	116339760	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr7:116339760G>T	ENST00000397752.3	+	2	822	c.622G>T	c.(622-624)Gat>Tat	p.D208Y	MET_ENST00000318493.6_Missense_Mutation_p.D208Y|MET_ENST00000436117.2_Missense_Mutation_p.D208Y	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	208	Sema.				axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			TTATTTCCCAGATCATCCATT	0.418000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				69	187					1.33661e-31	1.78945e-31	1	1	0
COL18A1	80781	broad.mit.edu	37	21	46925758	46925758	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr21:46925758C>T	ENST00000359759.4	+	36	4360	c.4339C>T	c.(4339-4341)Ctc>Ttc	p.L1447F	SLC19A1_ENST00000567670.1_Intron|COL18A1_ENST00000400337.2_Missense_Mutation_p.L1032F|COL18A1_ENST00000355480.5_Missense_Mutation_p.L1212F			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	1447	Nonhelical region 11 (NC11).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		GCAGGTGAGGCTCTGGGCTAC	0.682000													18	34					0	0	1	0	0
GPR160	26996	broad.mit.edu	37	3	169801905	169801905	+	Missense_Mutation	SNP	A	A	C			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr3:169801905A>C	ENST00000355897.5	+	4	753	c.145A>C	c.(145-147)Aac>Cac	p.N49H		NM_014373.2	NP_055188.1	Q9UJ42	GP160_HUMAN	G protein-coupled receptor 160	49						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|cervix(1)|kidney(1)|large_intestine(3)|lung(2)	8	all_cancers(22;3.26e-22)|all_epithelial(15;5.71e-27)|all_lung(20;8.41e-17)|Lung NSC(18;3.49e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			GAGAAGAAAAAACACCTGTCA	0.303000													8	109					0	0	1	0	0
ECHS1	1892	broad.mit.edu	37	10	135178173	135178173	+	Missense_Mutation	SNP	T	T	C			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr10:135178173T>C	ENST00000368547.3	-	7	1151	c.796A>G	c.(796-798)Acc>Gcc	p.T266A		NM_004092.3	NP_004083.3	P30084	ECHM_HUMAN	enoyl CoA hydratase, short chain, 1, mitochondrial	266					fatty acid beta-oxidation	mitochondrial matrix	enoyl-CoA hydratase activity|protein binding			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|prostate(1)|skin(1)	10		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;1.62e-06)|OV - Ovarian serous cystadenocarcinoma(35;5.75e-06)|Epithelial(32;7.58e-06)		GTGGCAAAGGTTGAATAAAAG	0.353000													19	52					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													8	98					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458161	248458161	+	Silent	SNP	A	A	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:248458161A>G	ENST00000317996.1	-	1	719	c.720T>C	c.(718-720)tcT>tcC	p.S240S		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			CCACATGTGAAGAGCAGGTGG	0.517000													13	161					0	0	1	0	0
GLIPR2	152007	broad.mit.edu	37	9	36147803	36147803	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr9:36147803G>A	ENST00000377960.4	+	2	68	c.34G>A	c.(34-36)Gag>Aag	p.E12K	GLIPR2_ENST00000396613.3_3'UTR|GLIPR2_ENST00000377959.1_Missense_Mutation_p.E12K|GLIPR2_ENST00000474050.1_3'UTR	NM_022343.2	NP_071738.1	Q9H4G4	GAPR1_HUMAN	GLI pathogenesis-related 2	12						extracellular region|Golgi membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|skin(3)	10						GTTTCATAATGAGGTCCTGAA	0.493000													102	253					0	0	1	0	0
SRPK2	6733	broad.mit.edu	37	7	104782488	104782488	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr7:104782488C>G	ENST00000357311.3	-	10	1648	c.1477G>C	c.(1477-1479)Gtt>Ctt	p.V493L	SRPK2_ENST00000489828.1_Missense_Mutation_p.V493L|SRPK2_ENST00000393651.3_Missense_Mutation_p.V504L	NM_001278273.1|NM_182691.1	NP_001265202.1|NP_872633.1	P78362	SRPK2_HUMAN	SRSF protein kinase 2	493	Protein kinase.				angiogenesis|cell differentiation|intracellular protein kinase cascade|negative regulation of viral genome replication|nuclear speck organization|positive regulation of cell cycle|positive regulation of cell proliferation|positive regulation of gene expression|positive regulation of neuron apoptosis|positive regulation of viral genome replication|spliceosome assembly	cytoplasm|nucleolus	14-3-3 protein binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(11)|large_intestine(6)|lung(4)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	35						GAGGCTGAAACCGTTCTGCTT	0.517000													46	117					0	0	1	0	0
SNX13	23161	broad.mit.edu	37	7	17931229	17931229	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr7:17931229C>A	ENST00000409389.1	-	4	430	c.258G>T	c.(256-258)agG>agT	p.R86S	SNX13_ENST00000409604.1_Missense_Mutation_p.R86S|SNX13_ENST00000428135.3_Missense_Mutation_p.R86S			Q9Y5W8	SNX13_HUMAN	sorting nexin 13	86					cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			breast(1)|central_nervous_system(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(13)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	38	Lung NSC(10;0.0261)|all_lung(11;0.0521)					TCTTAATAGTCCTGGCTTCCC	0.353000													6	64					0.000157383	0.000166922	1	1	0
HIPK1	204851	broad.mit.edu	37	1	114483824	114483824	+	Silent	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:114483824G>A	ENST00000369558.1	+	2	1051	c.819G>A	c.(817-819)caG>caA	p.Q273Q	HIPK1_ENST00000369555.2_Silent_p.Q273Q|HIPK1_ENST00000369559.4_Silent_p.Q273Q|HIPK1_ENST00000369554.2_Silent_p.Q273Q|HIPK1_ENST00000369561.4_Silent_p.Q273Q|HIPK1_ENST00000426820.2_Silent_p.Q273Q			Q86Z02	HIPK1_HUMAN	homeodomain interacting protein kinase 1	273	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|prostate(2)	39	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGTTGGAGCAGAACTTATATG	0.413000													24	81					0	0	1	0	0
HSPH1	10808	broad.mit.edu	37	13	31729698	31729698	+	Silent	SNP	A	A	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr13:31729698A>G	ENST00000320027.5	-	3	603	c.259T>C	c.(259-261)Ttg>Ctg	p.L87L	HSPH1_ENST00000429785.2_5'UTR|HSPH1_ENST00000380405.4_Silent_p.L87L|HSPH1_ENST00000445273.2_Silent_p.L89L|HSPH1_ENST00000380406.5_Silent_p.L87L	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	87					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		TCGTAACTCAAGTTTTCCTTC	0.338000													17	112					0	0	1	0	0
ELFN1	392617	broad.mit.edu	37	7	1785510	1785510	+	Silent	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr7:1785510C>G	ENST00000424383.2	+	3	1765	c.1278C>G	c.(1276-1278)ctC>ctG	p.L426L	ELFN1_ENST00000561626.1_Silent_p.L426L|ELFN1_ENST00000541472.1_Silent_p.L426L					extracellular leucine-rich repeat and fibronectin type III domain containing 1											endometrium(1)	1						TGGGCTGCCTCTTCGGCATGG	0.701000													3	8					0	0	1	0	0
IGLV8-61	28774	broad.mit.edu	37	22	22453327	22453327	+	RNA	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr22:22453327C>G	ENST00000390283.2	+	0	119																											AGTGGATTCTCAGACTGTGGT	0.517000													13	54					0	0	1	0	0
ZNF619	285267	broad.mit.edu	37	3	40529119	40529119	+	Missense_Mutation	SNP	A	A	C			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr3:40529119A>C	ENST00000447116.2	+	6	1545	c.1238A>C	c.(1237-1239)gAa>gCa	p.E413A	ZNF619_ENST00000522736.1_Missense_Mutation_p.E364A|ZNF619_ENST00000432264.2_Missense_Mutation_p.E373A|ZNF619_ENST00000314686.5_Missense_Mutation_p.E357A|ZNF619_ENST00000521353.1_Missense_Mutation_p.E413A|ZNF619_ENST00000520737.1_3'UTR|ZNF619_ENST00000456778.1_Missense_Mutation_p.E329A|ZNF619_ENST00000429348.2_Missense_Mutation_p.E373A	NM_001145082.2	NP_001138554.1	E9PCD9	E9PCD9_HUMAN	zinc finger protein 619	413					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0525)|Kidney(284;0.0661)		AAACCTTATGAATGTAAAGAG	0.458000													7	135					0	0	1	0	0
SLC6A19	340024	broad.mit.edu	37	5	1217037	1217037	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr5:1217037G>A	ENST00000304460.10	+	8	1206	c.1150G>A	c.(1150-1152)Gac>Aac	p.D384N		NM_001003841.2	NP_001003841.1	Q695T7	S6A19_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 19	384					cellular nitrogen compound metabolic process	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(25)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	all_cancers(3;3.55e-15)|Lung NSC(6;2.89e-14)|all_lung(6;2.2e-13)|all_epithelial(6;3.75e-10)		Epithelial(17;0.000356)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|Lung(60;0.185)			CCAGACCTGCGACATCAACGC	0.657000													48	163					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248637592	248637592	+	Missense_Mutation	SNP	T	T	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:248637592T>G	ENST00000359594.2	+	1	966	c.941T>G	c.(940-942)aTg>aGg	p.M314R		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	314					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CAGTCAAGAATGAACCAAGAA	0.488000													51	756					0	0	1	0	0
PKP1	5317	broad.mit.edu	37	1	201286883	201286883	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:201286883G>A	ENST00000263946.3	+	5	1281	c.1030G>A	c.(1030-1032)Gcc>Acc	p.A344T	PKP1_ENST00000475988.1_3'UTR|PKP1_ENST00000367324.3_Missense_Mutation_p.A344T|PKP1_ENST00000352845.3_Missense_Mutation_p.A344T	NM_000299.3	NP_000290.2	Q13835	PKP1_HUMAN	plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)	344					cell adhesion|cellular component disassembly involved in apoptosis|multicellular organismal development	desmosome|intermediate filament|nucleus	intermediate filament binding|signal transducer activity|structural constituent of epidermis			NS(2)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(5)|prostate(1)	22						AACCGGGAACGCCGAGATCCA	0.642000													13	47					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36044656	36044656	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr19:36044656C>A	ENST00000262623.3	-	17	2585	c.2557G>T	c.(2557-2559)Gac>Tac	p.D853Y		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	853					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	ACCAATCTGTCACGCTTTGGG	0.622000													11	13					0.000978159	0.00102414	1	1	0
ZNRD1-AS1	80862	broad.mit.edu	37	6	29974608	29974608	+	RNA	SNP	C	C	G	rs116569882	by1000genomes	TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr6:29974608C>G	ENST00000376797.3	-	0	1346				ZNRD1-AS1_ENST00000420251.1_RNA|HLA-J_ENST00000462773.1_RNA|ZNRD1-AS1_ENST00000425604.1_RNA|ZNRD1-AS1_ENST00000448093.1_RNA																							TCAGCACCGCCGTTTCCTGGC	0.711000													3	19					0	0	1	0	0
CENPP	401541	broad.mit.edu	37	9	95142087	95142087	+	Silent	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr9:95142087G>T	ENST00000375587.3	+	5	1025	c.510G>T	c.(508-510)ctG>ctT	p.L170L		NM_001012267.1	NP_001012267.1	Q6IPU0	CENPP_HUMAN	centromere protein P	170					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	chromosome, centromeric region|cytosol|nucleoplasm				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|skin(1)	16						TCCGAAGCCTGCATTTTTTTG	0.328000													18	99					7.45023e-12	9.08112e-12	1	1	0
ZGPAT	84619	broad.mit.edu	37	20	62340199	62340199	+	Silent	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr20:62340199G>T	ENST00000328969.5	+	2	394	c.267G>T	c.(265-267)gcG>gcT	p.A89A	ZGPAT_ENST00000357119.4_Silent_p.A89A|ZGPAT_ENST00000448100.1_Silent_p.A89A|ZGPAT_ENST00000369967.3_Silent_p.A89A|ZGPAT_ENST00000490623.1_3'UTR|ZGPAT_ENST00000355969.6_Silent_p.A89A	NM_032527.4	NP_115916.3	Q8N5A5	ZGPAT_HUMAN	zinc finger, CCCH-type with G patch domain	89					negative regulation of epidermal growth factor receptor activity|negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)	14	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					TCACTGAGGCGGTGGAGGCAC	0.662000													30	66					1.56738e-10	1.87321e-10	1	1	0
SLC2A6	11182	broad.mit.edu	37	9	136340214	136340214	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr9:136340214C>T	ENST00000371899.4	-	6	873	c.796G>A	c.(796-798)Gag>Aag	p.E266K	SLC2A6_ENST00000371897.4_Missense_Mutation_p.E266K|SLC2A6_ENST00000485978.1_5'UTR	NM_017585.3	NP_060055.2	Q9UGQ3	GTR6_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 6	266						integral to membrane|plasma membrane	D-glucose transmembrane transporter activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|prostate(3)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(145;8.47e-08)|Epithelial(140;9.37e-07)|all cancers(34;1.03e-05)		GCCCGTGCCTCAGCCCACGAT	0.682000													3	5					0	0	1	0	0
PSTPIP1	9051	broad.mit.edu	37	15	77317648	77317648	+	Missense_Mutation	SNP	C	C	T	rs77026017	byFrequency	TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr15:77317648C>T	ENST00000558012.1	+	4	725	c.236C>T	c.(235-237)tCc>tTc	p.S79F	PSTPIP1_ENST00000559295.1_Missense_Mutation_p.S79F|PSTPIP1_ENST00000267939.5_Missense_Mutation_p.S78F|PSTPIP1_ENST00000379595.3_Missense_Mutation_p.S79F	NM_003978.3	NP_003969.2	O43586	PPIP1_HUMAN	proline-serine-threonine phosphatase interacting protein 1	79	FCH.				cell adhesion|signal transduction	cleavage furrow|lamellipodium|perinuclear region of cytoplasm	catalytic activity			breast(1)|endometrium(3)|lung(2)|ovary(2)|upper_aerodigestive_tract(1)	9						TCCTTTGACTCCTTGAAGCAG	0.617000													24	59					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48367239	48367239	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr12:48367239C>T	ENST00000380518.3	-	54	4579	c.4415G>A	c.(4414-4416)gGg>gAg	p.G1472E	COL2A1_ENST00000337299.6_Missense_Mutation_p.G1403E|COL2A1_ENST00000493991.1_5'UTR	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	1472	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	CTGCTCGGGCCCTCCTATGTC	0.517000													47	120					0	0	1	0	0
LIPI	149998	broad.mit.edu	37	21	15554083	15554083	+	Silent	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr21:15554083G>T	ENST00000344577.2	-	4	727	c.702C>A	c.(700-702)tcC>tcA	p.S234S	LIPI_ENST00000536861.1_Silent_p.S213S	NM_198996.2	NP_945347.1	Q6XZB0	LIPI_HUMAN	lipase, member I	213					lipid catabolic process	extracellular region|extracellular space|membrane|plasma membrane	heparin binding|phospholipase activity			endometrium(1)|kidney(13)|large_intestine(9)|liver(3)|lung(24)|ovary(3)|urinary_tract(1)	54				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.0015)|Colorectal(24;0.00693)|Lung(58;0.166)		TGTTACCATTGGAGTCAGAAT	0.403000													21	41					1.96292e-10	2.33454e-10	1	1	0
HOXD13	3239	broad.mit.edu	37	2	176957890	176957890	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr2:176957890C>G	ENST00000392539.3	+	1	272	c.272C>G	c.(271-273)tCt>tGt	p.S91C		NM_000523.3	NP_000514.2	P35453	HXD13_HUMAN	homeobox D13	91	Poly-Ser.				skeletal system development|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0526)|READ - Rectum adenocarcinoma(9;0.0678)		TCGTCGTCCTCTTCTGCCGTT	0.766000			T	NUP98	AML*								6	21					0	0	1	0	0
SLC37A4	2542	broad.mit.edu	37	11	118896717	118896717	+	Missense_Mutation	SNP	A	A	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:118896717A>G	ENST00000545985.1	-	9	1700	c.944T>C	c.(943-945)aTg>aCg	p.M315T	SLC37A4_ENST00000357590.5_Missense_Mutation_p.M315T|SLC37A4_ENST00000538950.1_Missense_Mutation_p.M242T|SLC37A4_ENST00000330775.7_Missense_Mutation_p.M314T|SLC37A4_ENST00000525102.1_5'UTR	NM_001164277.1|NM_001467.5	NP_001157749.1|NP_001458.1	O43826	G6PT1_HUMAN	solute carrier family 37 (glucose-6-phosphate transporter), member 4	315					glucose homeostasis|glucose metabolic process	endoplasmic reticulum membrane|integral to endoplasmic reticulum membrane|integral to membrane	glucose-6-phosphate transmembrane transporter activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|prostate(1)	6	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.58e-05)		GAAGAGGTACATGGACACTGT	0.567000													8	6					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	106918722	106918722	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr10:106918722G>T	ENST00000369701.3	+	11	1929	c.1702G>T	c.(1702-1704)Gag>Tag	p.E568*		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	568						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CTCTAGCAAGGAGACAGCCCC	0.418000													15	69					1.02788e-11	1.24669e-11	1	1	0
RP3-462D8.2	0	broad.mit.edu	37	22	25678979	25678979	+	RNA	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr22:25678979C>G	ENST00000444383.1	-	0	82																											CAAGGCGACTCCGGCCGCCCG	0.711000													3	4					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17437058	17437058	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr20:17437058G>T	ENST00000262545.2	+	10	1482	c.1167G>T	c.(1165-1167)gaG>gaT	p.E389D	PCSK2_ENST00000536609.1_Missense_Mutation_p.E354D|PCSK2_ENST00000377899.1_Missense_Mutation_p.E370D	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	389	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTGCCCCCGAGGCAGCTGGTG	0.542000													33	176					1.99505e-19	2.5591e-19	1	1	0
C12orf36	283422	broad.mit.edu	37	12	13526240	13526240	+	Silent	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr12:13526240C>T	ENST00000318426.2	-	3	532	c.315G>A	c.(313-315)caG>caA	p.Q105Q	C12orf36_ENST00000527705.2_Silent_p.Q105Q					chromosome 12 open reading frame 36											lung(3)|skin(3)	6				BRCA - Breast invasive adenocarcinoma(232;0.198)		TCTTCAGCCTCTGAATCCTCC	0.483000													62	238					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112667594	112667594	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr12:112667594C>T	ENST00000550722.1	-	41	6384	c.5989G>A	c.(5989-5991)Gcc>Acc	p.A1997T	HECTD4_ENST00000377560.5_Missense_Mutation_p.A1971T|HECTD4_ENST00000430131.2_Missense_Mutation_p.A1721T	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		TGAAGTTTGGCAAGTTTCCTG	0.478000													37	109					0	0	1	0	0
PI4KA	5297	broad.mit.edu	37	22	21066883	21066883	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr22:21066883C>T	ENST00000255882.6	-	50	5779	c.5693G>A	c.(5692-5694)tGc>tAc	p.C1898Y	PI4KA_ENST00000414196.3_Missense_Mutation_p.C650Y|PI4KA_ENST00000572273.1_Missense_Mutation_p.C1840Y	NM_058004.3	NP_477352.3	P42356	PI4KA_HUMAN	phosphatidylinositol 4-kinase, catalytic, alpha	1840	PI3K/PI4K.				phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|synaptic transmission	Golgi-associated vesicle	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			breast(3)|endometrium(8)|kidney(9)|large_intestine(19)|lung(29)|ovary(1)|pancreas(1)|prostate(3)|salivary_gland(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	79	all_cancers(11;7.59e-25)|all_epithelial(7;1.34e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)			GTCGGGGATGCACTCGATCAC	0.647000													4	17					0	0	1	0	0
PEX5L	51555	broad.mit.edu	37	3	179533763	179533763	+	Silent	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr3:179533763G>A	ENST00000467460.1	-	10	1299	c.969C>T	c.(967-969)ttC>ttT	p.F323F	PEX5L_ENST00000464614.1_Silent_p.F215F|PEX5L_ENST00000392649.3_Silent_p.F215F|PEX5L_ENST00000263962.8_Silent_p.F321F|PEX5L_ENST00000485199.1_Silent_p.F288F|PEX5L_ENST00000476138.1_Silent_p.F280F|PEX5L_ENST00000472994.1_Silent_p.F264F|PEX5L_ENST00000468741.1_Silent_p.F131F|PEX5L_ENST00000467440.2_5'UTR|PEX5L_ENST00000465751.1_Silent_p.F299F	NM_001256751.1|NM_016559.2	NP_001243680.1|NP_057643.1	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	323					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			GCCAGTCCTTGAAGGGGTTTT	0.453000													19	74					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	T	rs121913530		TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr12:25398285C>T	ENST00000311936.3	-	2	225	c.34G>A	c.(34-36)Ggt>Agt	p.G12S	KRAS_ENST00000557334.1_Missense_Mutation_p.G12S|KRAS_ENST00000256078.4_Missense_Mutation_p.G12S|KRAS_ENST00000556131.1_Missense_Mutation_p.G12S	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			10	25					0	0	1	0	0
PCDHA7	56141	broad.mit.edu	37	5	140215837	140215837	+	Silent	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr5:140215837C>A	ENST00000525929.1	+	1	1869	c.1869C>A	c.(1867-1869)cgC>cgA	p.R623R	PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA7_ENST00000378125.3_Silent_p.R623R|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA4_ENST00000512229.2_Intron	NM_018910.2	NP_061733.1														NS(2)|biliary_tract(1)|breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(27)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCGTTCCGCGTGGGGCTGT	0.632000													23	98					1.28384e-07	1.43626e-07	1	1	0
KEAP1	9817	broad.mit.edu	37	19	10600008	10600008	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr19:10600008C>T	ENST00000171111.5	-	5	2115	c.1568G>A	c.(1567-1569)gGg>gAg	p.G523E	KEAP1_ENST00000393623.2_Missense_Mutation_p.G523E	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	523					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			ATCATAGCCCCCAGCAGCATA	0.587000													26	26					0	0	1	0	0
NHLRC2	374354	broad.mit.edu	37	10	115636523	115636523	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr10:115636523C>T	ENST00000369301.3	+	3	787	c.575C>T	c.(574-576)tCa>tTa	p.S192L		NM_198514.3	NP_940916.2	Q8NBF2	NHLC2_HUMAN	NHL repeat containing 2	192	Thioredoxin.				cell redox homeostasis					breast(1)|endometrium(2)|kidney(4)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	15				Epithelial(162;0.017)|all cancers(201;0.0187)		TTATATACTTCAATTGCTTTA	0.348000													22	84					0	0	1	0	0
GCNT2	2651	broad.mit.edu	37	6	10557572	10557572	+	Missense_Mutation	SNP	C	C	A	rs56065392		TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr6:10557572C>A	ENST00000316170.3	+	1	1333	c.916C>A	c.(916-918)Cca>Aca	p.P306T	GCNT2_ENST00000495262.1_Intron|GCNT2_ENST00000397423.2_Intron|GCNT2_ENST00000379597.3_Intron|GCNT2_ENST00000410107.1_Intron	NM_001491.2	NP_001482.1	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	308						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		CAATAGGATTCCAGGTACGTA	0.413000													7	160					0.00198382	0.00205947	1	1	0
POTEE	445582	broad.mit.edu	37	2	132021446	132021446	+	Silent	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr2:132021446C>A	ENST00000356920.5	+	15	2512	c.2418C>A	c.(2416-2418)acC>acA	p.T806T	POTEE_ENST00000358087.5_3'UTR|PLEKHB2_ENST00000404460.1_Intron|PLEKHB2_ENST00000303908.3_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	806	Actin-like.						ATP binding										TCCTGCTGACCGAGGCCCCCC	0.597000													46	160					5.82388e-19	7.43152e-19	1	1	0
CUZD1	50624	broad.mit.edu	37	10	124595810	124595810	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr10:124595810C>G	ENST00000368904.1	-	8	1823	c.874G>C	c.(874-876)Gag>Cag	p.E292Q	CUZD1_ENST00000545804.1_Missense_Mutation_p.E292Q|CUZD1_ENST00000392790.1_Missense_Mutation_p.E292Q			Q86UP6	CUZD1_HUMAN	CUB and zona pellucida-like domains 1	292	ZP.				cell cycle|cell division|cell proliferation|substrate-dependent cell migration, cell attachment to substrate|trypsinogen activation	integral to membrane|transport vesicle membrane|zymogen granule membrane				NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|stomach(1)	39		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.126)|COAD - Colon adenocarcinoma(40;0.141)		TTAAAAGCCTCTAGGTAGGAT	0.348000													31	75					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2857522	2857522	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr8:2857522G>T	ENST00000602557.1	-	54	8719	c.8164C>A	c.(8164-8166)Ctg>Atg	p.L2722M	CSMD1_ENST00000602723.1_Missense_Mutation_p.L2664M|CSMD1_ENST00000542608.1_Missense_Mutation_p.L2663M|CSMD1_ENST00000537824.1_Missense_Mutation_p.L2721M|CSMD1_ENST00000520002.1_Missense_Mutation_p.L2722M|CSMD1_ENST00000400186.3_Missense_Mutation_p.L2664M			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2722	Sushi 18.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGGTCTTGCAGGCATATCCTC	0.493000													56	181					7.89702e-26	1.05151e-25	1	1	0
ARL4C	10123	broad.mit.edu	37	2	235404667	235404667	+	Silent	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr2:235404667C>T	ENST00000390645.2	-	1	1030	c.564G>A	c.(562-564)caG>caA	p.Q188Q	ARL4C_ENST00000339728.3_Silent_p.Q188Q	NM_005737.3	NP_005728.2	P56559	ARL4C_HUMAN	ADP-ribosylation factor-like 4C	188					endocytic recycling|small GTPase mediated signal transduction	cytoplasm|filopodium|nucleus|plasma membrane	alpha-tubulin binding|GTP binding|GTPase activity			endometrium(1)|ovary(1)|skin(1)|urinary_tract(1)	4		Breast(86;0.000596)|Renal(207;0.00339)|all_lung(227;0.00354)|all_hematologic(139;0.0494)|Lung NSC(271;0.0496)|Lung SC(224;0.164)|all_neural(83;0.173)		Epithelial(121;2.6e-19)|BRCA - Breast invasive adenocarcinoma(100;0.000296)|Lung(119;0.002)|LUSC - Lung squamous cell carcinoma(224;0.0048)		GCTTCTTCTTCTGCTTGAGGG	0.577000													12	58					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127843829	127843829	+	Silent	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr10:127843829G>A	ENST00000368679.4	-	4	615	c.306C>T	c.(304-306)gaC>gaT	p.D102D	ADAM12_ENST00000368676.4_Silent_p.D102D	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	102					cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CATCAGTACCGTCTTGCAGAT	0.443000													44	103					0	0	1	0	0
MST1R	4486	broad.mit.edu	37	3	49940721	49940721	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr3:49940721C>T	ENST00000296474.3	-	1	349	c.322G>A	c.(322-324)Ggc>Agc	p.G108S	CTD-2330K9.2_ENST00000435478.1_RNA|MST1R_ENST00000344206.4_Missense_Mutation_p.G108S	NM_002447.2	NP_002438.2	Q04912	RON_HUMAN	macrophage stimulating 1 receptor (c-met-related tyrosine kinase)	108	Sema.				cellular component movement|defense response|multicellular organismal development|positive regulation of cell proliferation|single fertilization|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|macrophage colony-stimulating factor receptor activity|protein binding			cervix(1)|endometrium(5)|large_intestine(3)|lung(17)|ovary(5)|prostate(2)|skin(1)|urinary_tract(3)	37				BRCA - Breast invasive adenocarcinoma(193;4.65e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00553)|Kidney(197;0.00625)		GGTCCTGGGCCACAGGCTGCA	0.672000													21	107					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124765802	124765802	+	Missense_Mutation	SNP	T	T	C			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:124765802T>C	ENST00000306534.3	-	5	1171	c.686A>G	c.(685-687)cAg>cGg	p.Q229R	ROBO4_ENST00000533054.1_Missense_Mutation_p.Q84R|ROBO4_ENST00000526899.1_5'UTR	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	229					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CGTGTAGTCCTGGGGCTCTGT	0.607000													9	53					0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22807613	22807613	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr18:22807613G>A	ENST00000361524.3	-	4	417	c.269C>T	c.(268-270)tCa>tTa	p.S90L	ZNF521_ENST00000538137.2_Missense_Mutation_p.S90L|ZNF521_ENST00000579111.1_5'UTR|ZNF521_ENST00000584787.1_5'UTR	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	90					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GCTAGAAGGTGAGGAAGCTGG	0.478000			T	PAX5	ALL								24	50					0	0	1	0	0
GBP4	115361	broad.mit.edu	37	1	89652016	89652016	+	Splice_Site	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:89652016C>T	ENST00000355754.6	-	10	1804	c.1707_splice	c.e10+1	p.K569_splice		NM_052941.4	NP_443173.2	Q96PP9	GBP4_HUMAN	guanylate binding protein 4	569						cytoplasm	GTP binding|GTPase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(19)|skin(1)|stomach(2)|urinary_tract(1)	33				all cancers(265;0.00723)|Epithelial(280;0.0291)		GGAGACTCACCTTCAGCTTGT	0.473000													46	98					0	0	1	0	0
PCSK2	5126	broad.mit.edu	37	20	17437059	17437059	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr20:17437059G>T	ENST00000262545.2	+	10	1483	c.1168G>T	c.(1168-1170)Gca>Tca	p.A390S	PCSK2_ENST00000536609.1_Missense_Mutation_p.A355S|PCSK2_ENST00000377899.1_Missense_Mutation_p.A371S	NM_002594.3	NP_002585.2	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	390	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(5)|large_intestine(7)|lung(17)|ovary(3)|pancreas(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	53					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGCCCCCGAGGCAGCTGGTGT	0.542000													34	175					1.36615e-20	1.76161e-20	1	1	0
DLGAP4	22839	broad.mit.edu	37	20	35128032	35128032	+	Silent	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr20:35128032C>T	ENST00000339266.5	+	7	2052	c.2052C>T	c.(2050-2052)ccC>ccT	p.P684P	DLGAP4_ENST00000340491.4_Silent_p.P145P|DLGAP4_ENST00000373913.3_Intron|DLGAP4_ENST00000401952.2_Intron|DLGAP4_ENST00000475894.1_3'UTR|DLGAP4_ENST00000373907.2_Silent_p.P684P	NM_001042486.2	NP_001035951.1	Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	684					cell-cell signaling	membrane	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				AGCCCAGTCCCGCTACCAAAT	0.542000													8	20					0	0	1	0	0
ASTN2	23245	broad.mit.edu	37	9	119976782	119976782	+	Silent	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr9:119976782C>A	ENST00000313400.4	-	3	970	c.870G>T	c.(868-870)ctG>ctT	p.L290L	ASTN2_ENST00000361477.3_5'UTR|ASTN2_ENST00000373996.3_Silent_p.L290L|ASTN2_ENST00000361209.2_Silent_p.L290L			O75129	ASTN2_HUMAN	astrotactin 2	290						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						CATAGTCATCCAGGATGGGAG	0.622000													12	65					6.40141e-05	6.87871e-05	1	1	0
AUTS2	26053	broad.mit.edu	37	7	70239076	70239076	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr7:70239076G>T	ENST00000342771.4	+	12	2214	c.1893G>T	c.(1891-1893)aaG>aaT	p.K631N	AUTS2_ENST00000406775.2_Intron	NM_015570.2	NP_056385.1	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2	631										breast(2)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	50		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		TACTCCAAAAGGACCCGAGGG	0.532000													16	47					6.94344e-10	8.17857e-10	1	1	0
HPS6	79803	broad.mit.edu	37	10	103827455	103827455	+	Nonsense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr10:103827455C>T	ENST00000299238.5	+	1	2309	c.2224C>T	c.(2224-2226)Cag>Tag	p.Q742*		NM_024747.5	NP_079023.2	Q86YV9	HPS6_HUMAN	Hermansky-Pudlak syndrome 6	742						cytosol|early endosome membrane|endoplasmic reticulum|microsome				endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|prostate(1)	11		Colorectal(252;0.122)		Epithelial(162;5.93e-08)|all cancers(201;1.03e-06)		CCTGCTGGAGCAGACTGGGGC	0.632000									Hermansky-Pudlak syndrome				22	56					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10263332	10263332	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr17:10263332G>T	ENST00000418404.3	-	6	753	c.590C>A	c.(589-591)gCa>gAa	p.A197E	MYH13_ENST00000252172.4_Missense_Mutation_p.A197E|MYH13_ENST00000570743.1_Missense_Mutation_p.A197E			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	197	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						TGCAATTGTTGCAAAATACTG	0.502000													13	88					0.000219431	0.000231727	1	1	0
DIAPH3	81624	broad.mit.edu	37	13	60544092	60544092	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr13:60544092C>A	ENST00000400324.4	-	17	2280	c.2060G>T	c.(2059-2061)tGt>tTt	p.C687F	DIAPH3_ENST00000377908.2_Missense_Mutation_p.C676F|DIAPH3_ENST00000400319.1_Missense_Mutation_p.C617F|DIAPH3_ENST00000400330.1_Missense_Mutation_p.C687F|DIAPH3_ENST00000400320.1_Missense_Mutation_p.C641F|DIAPH3_ENST00000267215.4_Missense_Mutation_p.C687F|DIAPH3_ENST00000465066.1_5'UTR	NM_001042517.1|NM_001258366.1	NP_001035982.1|NP_001245295.1	Q9NSV4	DIAP3_HUMAN	diaphanous-related formin 3	687	FH2.				actin cytoskeleton organization		actin binding|Rho GTPase binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		TTGTTGGCAACAAAATGTATT	0.244000													7	21					0.0293803	0.0301179	1	1	0
OR14C36	127066	broad.mit.edu	37	1	248512285	248512285	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:248512285G>T	ENST00000317861.1	+	1	209	c.209G>T	c.(208-210)tGc>tTc	p.C70F		NM_001001918.1	NP_001001918.1	Q8NHC7	O14CZ_HUMAN	olfactory receptor, family 14, subfamily C, member 36	70					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|liver(2)|lung(20)|ovary(2)|prostate(3)|skin(7)|upper_aerodigestive_tract(2)	43						TTGGATGCCTGCTACATTTCT	0.493000													43	295					5.20006e-24	6.88657e-24	1	1	0
TROVE2	6738	broad.mit.edu	37	1	193038730	193038730	+	Silent	SNP	A	A	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:193038730A>G	ENST00000367446.3	+	2	756	c.546A>G	c.(544-546)ctA>ctG	p.L182L	TROVE2_ENST00000400968.2_Silent_p.L182L|TROVE2_ENST00000432079.1_Intron|TROVE2_ENST00000367445.3_Silent_p.L182L|TROVE2_ENST00000416058.2_5'UTR|TROVE2_ENST00000367444.3_Silent_p.L182L|TROVE2_ENST00000460715.2_Intron|TROVE2_ENST00000367443.1_Silent_p.L182L|TROVE2_ENST00000367441.1_Silent_p.L182L	NM_004600.5	NP_004591.2	P10155	RO60_HUMAN	TROVE domain family, member 2	182	TROVE.				transcription from RNA polymerase III promoter	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|RNA binding			biliary_tract(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(7)|prostate(2)|urinary_tract(1)	21						ACAAAGATCTATTAAGATTGT	0.398000													28	141					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24509790	24509790	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr5:24509790G>T	ENST00000264463.4	-	7	1648	c.1141C>A	c.(1141-1143)Cct>Act	p.P381T		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	381	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		AAAACAGGAGGTTCATCCACA	0.393000										HNSCC(23;0.051)			18	61					9.16793e-09	1.0595e-08	1	1	0
BTG4	54766	broad.mit.edu	37	11	111369487	111369487	+	Silent	SNP	A	A	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:111369487A>G	ENST00000525791.1	-	2	199	c.15T>C	c.(13-15)atT>atC	p.I5I	BTG4_ENST00000356018.2_Silent_p.I5I			Q9NY30	BTG4_HUMAN	B-cell translocation gene 4	5					cell cycle arrest|negative regulation of cell proliferation|neuron differentiation			p.I5I(1)		large_intestine(2)|upper_aerodigestive_tract(1)	3		all_cancers(61;3.78e-13)|all_epithelial(67;5.29e-08)|Melanoma(852;3.15e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0204)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.22e-06)|BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|all cancers(92;2.18e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0509)		CTGTTGTTGCAATTTCATCTC	0.303000													22	27					0	0	1	0	0
LOC101929006	101929006	broad.mit.edu	37	6	29231760	29231760	+	RNA	SNP	A	A	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr6:29231760A>G	ENST00000441381.1	+	0	231																											GAAATTGCATAGAAGAAAAAG	0.403000													53	161					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197053535	197053535	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:197053535C>G	ENST00000367409.4	-	28	10609	c.10353G>C	c.(10351-10353)ttG>ttC	p.L3451F	ASPM_ENST00000294732.7_Missense_Mutation_p.L1866F|ASPM_ENST00000367408.1_Missense_Mutation_p.L1116F	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	3451					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						TATCTCTTCTCAAAACCCAAT	0.328000													9	66					0	0	1	0	0
TCL6	27004	broad.mit.edu	37	14	96135857	96135857	+	RNA	SNP	C	C	T	rs1748965	by1000genomes	TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr14:96135857C>T	ENST00000467865.1	+	0	1821				RP11-1070N10.6_ENST00000461160.1_RNA																large_intestine(1)|lung(7)	8		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		tgagccaccacgcccggtcac	0.542000			T	TRA@	T-ALL								4	46					0	0	1	0	0
PSG2	5670	broad.mit.edu	37	19	43585117	43585117	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr19:43585117C>T	ENST00000406487.1	-	2	444	c.346G>A	c.(346-348)Gac>Aac	p.D116N		NM_031246.3	NP_112536.2	P11465	PSG2_HUMAN	pregnancy specific beta-1-glycoprotein 2	116	Ig-like V-type.				cell migration|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(24)|ovary(1)|pancreas(2)|prostate(6)|stomach(2)|urinary_tract(2)	49		Prostate(69;0.00682)				GATCCTGCGTCCTCCCGGGTG	0.448000													60	284					0	0	1	0	0
DCTN1	1639	broad.mit.edu	37	2	74593475	74593475	+	Missense_Mutation	SNP	A	A	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr2:74593475A>T	ENST00000361874.3	-	23	2973	c.2656T>A	c.(2656-2658)Tat>Aat	p.Y886N	DCTN1_ENST00000495643.1_5'UTR|DCTN1_ENST00000407639.2_Missense_Mutation_p.Y752N|DCTN1_ENST00000394003.3_Missense_Mutation_p.Y879N|DCTN1_ENST00000409868.1_Missense_Mutation_p.Y869N|DCTN1_ENST00000409567.3_Missense_Mutation_p.Y866N|DCTN1_ENST00000409438.1_Missense_Mutation_p.Y752N|DCTN1_ENST00000409240.1_Missense_Mutation_p.Y849N	NM_004082.4	NP_004073.2	Q14203	DCTN1_HUMAN	dynactin 1	886					cell death|G2/M transition of mitotic cell cycle|mitosis|nervous system development	centrosome|cytosol|kinetochore|microtubule|spindle pole	motor activity|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(1)|skin(3)	45						AGACACTCATAGGGGCTGCTG	0.582000													33	60					0	0	1	0	0
TSHZ3	57616	broad.mit.edu	37	19	31770192	31770192	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr19:31770192C>G	ENST00000240587.4	-	2	834	c.507G>C	c.(505-507)caG>caC	p.Q169H		NM_020856.2	NP_065907.2	Q63HK5	TSH3_HUMAN	teashirt zinc finger homeobox 3	169					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|endometrium(15)|kidney(9)|large_intestine(20)|lung(60)|ovary(4)|pancreas(2)|prostate(4)|skin(5)	123	Esophageal squamous(110;0.226)					CCATGGCGCTCTGGTGCCAGT	0.642000													9	33					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18883831	18883831	+	Missense_Mutation	SNP	T	T	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr16:18883831T>G	ENST00000446231.2	-	14	2418	c.2006A>C	c.(2005-2007)tAt>tCt	p.Y669S	SMG1_ENST00000389467.3_Missense_Mutation_p.Y669S			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	669	Interaction with SMG8 and SMG9.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						ACAATGAGAATACAATGTGTA	0.353000													4	19					0	0	1	0	0
MKL2	57496	broad.mit.edu	37	16	14342866	14342866	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr16:14342866G>T	ENST00000571589.1	+	13	2503	c.2331G>T	c.(2329-2331)ttG>ttT	p.L777F	MKL2_ENST00000318282.5_Missense_Mutation_p.L727F|MKL2_ENST00000574045.1_Missense_Mutation_p.L727F|MKL2_ENST00000341243.5_Missense_Mutation_p.L766F	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	766	Gln-rich.				cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CCTCAGGCTTGGCCCCAACTG	0.498000													12	70					0.00244969	0.00253239	1	1	0
ZNF629	23361	broad.mit.edu	37	16	30794329	30794329	+	Silent	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr16:30794329G>T	ENST00000262525.4	-	3	1527	c.1320C>A	c.(1318-1320)atC>atA	p.I440I		NM_001080417.1	NP_001073886.1	Q9UEG4	ZN629_HUMAN	zinc finger protein 629	440					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(3)|urinary_tract(1)	22			Colorectal(24;0.198)			TGGAGCTCATGATGAAGCTCT	0.617000													34	81					1.56442e-22	2.04964e-22	1	1	0
BCDIN3D	144233	broad.mit.edu	37	12	50236683	50236683	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr12:50236683G>A	ENST00000333924.4	-	1	229	c.188C>T	c.(187-189)cCc>cTc	p.P63L		NM_181708.2	NP_859059.1	Q7Z5W3	BN3D2_HUMAN	BCDIN3 domain containing	63	Bin3-type SAM.						methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|skin(1)|stomach(1)	9						CCCGTTCTCGGGACTCTCAGG	0.617000													48	104					0	0	1	0	0
PHACTR3	116154	broad.mit.edu	37	20	58381109	58381109	+	Silent	SNP	G	G	C			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr20:58381109G>C	ENST00000371015.1	+	8	1655	c.1188G>C	c.(1186-1188)cgG>cgC	p.R396R	PHACTR3_ENST00000355648.4_Silent_p.R355R|PHACTR3_ENST00000395639.4_Silent_p.R285R|PHACTR3_ENST00000395636.2_Silent_p.R355R|PHACTR3_ENST00000541461.1_Silent_p.R355R|PHACTR3_ENST00000361300.4_Silent_p.R285R|PHACTR3_ENST00000359926.3_Silent_p.R393R	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	396						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			CACTGCCACGGAAATGCAAGA	0.537000													86	286					0	0	1	0	0
HELZ2	85441	broad.mit.edu	37	20	62198235	62198235	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr20:62198235C>T	ENST00000467148.1	-	6	2545	c.2476G>A	c.(2476-2478)Gag>Aag	p.E826K	HELZ2_ENST00000427522.2_Missense_Mutation_p.E257K	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		CACCTCTGCTCGCGGCCGCCC	0.687000													20	59					0	0	1	0	0
EVA1B	55194	broad.mit.edu	37	1	36788625	36788625	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:36788625C>T	ENST00000270824.1	-	2	305	c.14G>A	c.(13-15)cGa>cAa	p.R5Q	EVA1B_ENST00000490466.1_5'UTR|SH3D21_ENST00000474766.1_Intron	NM_018166.1	NP_060636.1			eva-1 homolog B (C. elegans)																		CATGTCCCTTCGCGGGGCATC	0.672000													19	38					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76450734	76450734	+	Silent	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr17:76450734G>A	ENST00000389840.5	-	64	10306	c.10182C>T	c.(10180-10182)gaC>gaT	p.D3394D	DNAH17_ENST00000586052.1_5'UTR|DNAH17_ENST00000585328.1_Silent_p.D3403D					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CCACGTCCGCGTCATCTGTCA	0.622000													15	65					0	0	1	0	0
ZNF816	125893	broad.mit.edu	37	19	53454016	53454016	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr19:53454016C>T	ENST00000357666.4	-	5	1312	c.1012G>A	c.(1012-1014)Gag>Aag	p.E338K	ZNF321P_ENST00000391777.3_Intron|ZNF816_ENST00000444460.2_Missense_Mutation_p.E338K|ZNF816_ENST00000434371.2_Intron	NM_001031665.2	NP_001026835.1	Q0VGE8	ZN816_HUMAN	zinc finger protein 816	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(10)|lung(9)|stomach(1)|urinary_tract(2)	27						TAAGGTTTCTCTCCAGTATGA	0.413000													109	181					0	0	1	0	0
LOC401127	401127	broad.mit.edu	37	4	39482684	39482684	+	RNA	SNP	A	A	C	rs2260645	by1000genomes	TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr4:39482684A>C	ENST00000513652.1	+	0	691																											TCTGGGACACAGCCTCAGGCC	0.512000													4	62					0	0	1	0	0
TNKS	8658	broad.mit.edu	37	8	9609263	9609263	+	Missense_Mutation	SNP	G	G	C			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr8:9609263G>C	ENST00000310430.6	+	19	3003	c.2977G>C	c.(2977-2979)Gac>Cac	p.D993H	TNKS_ENST00000518281.1_Missense_Mutation_p.D756H	NM_003747.2	NP_003738.2	O95271	TNKS1_HUMAN	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase	993					mitotic spindle organization|mRNA transport|negative regulation of DNA binding|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of telomere maintenance via telomerase|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein poly-ADP-ribosylation|protein polyubiquitination|protein transport|spindle assembly|transmembrane transport|Wnt receptor signaling pathway	chromosome, centromeric region|Golgi membrane|microsome|nuclear chromosome, telomeric region|nuclear membrane|nuclear pore|pericentriolar material	NAD+ ADP-ribosyltransferase activity|protein binding|zinc ion binding			NS(1)|endometrium(10)|kidney(6)|large_intestine(4)|lung(17)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	49				COAD - Colon adenocarcinoma(149;0.0467)		CAGCAGCATAGACAACCTCAC	0.572000													56	166					0	0	1	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	104440393	104440393	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chrX:104440393G>A	ENST00000372582.1	+	3	1075	c.319G>A	c.(319-321)Gag>Aag	p.E107K	IL1RAPL2_ENST00000344799.4_Missense_Mutation_p.E107K	NM_017416.1	NP_059112.1	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	107	Ig-like C2-type 1.				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(14)|lung(23)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TCACTCAGCTGAGGCACAAGA	0.423000													5	101					0	0	1	0	0
SPICE1	152185	broad.mit.edu	37	3	113172770	113172770	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr3:113172770G>A	ENST00000295872.4	-	14	1944	c.1685C>T	c.(1684-1686)cCt>cTt	p.P562L		NM_144718.3	NP_653319.1	Q8N0Z3	SPICE_HUMAN	spindle and centriole associated protein 1	562					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						TCGTGGAGCAGGACGAGTTTG	0.338000													19	55					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92624096	92624096	+	Silent	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:92624096C>A	ENST00000298047.6	+	27	13604	c.13587C>A	c.(13585-13587)ggC>ggA	p.G4529G	FAT3_ENST00000533797.1_Silent_p.G832G|FAT3_ENST00000525166.1_Silent_p.G4379G|FAT3_ENST00000409404.2_Silent_p.G4497G			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	4529					homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AGCCCACAGGCCCAGCAGACA	0.557000										TCGA Ovarian(4;0.039)			26	15					3.08376e-08	3.51405e-08	1	1	0
LVRN	206338	broad.mit.edu	37	5	115298371	115298371	+	Silent	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr5:115298371G>A	ENST00000357872.4	+	1	181	c.57G>A	c.(55-57)ctG>ctA	p.L19L	AQPEP_ENST00000395528.2_5'UTR	NM_173800.4	NP_776161.3	Q6Q4G3	AMPQ_HUMAN		19					proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding										CCCTGCTGCTGGCTGGGCTGG	0.701000													5	44					0	0	1	0	0
C2orf16	84226	broad.mit.edu	37	2	27800981	27800981	+	Silent	SNP	A	A	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr2:27800981A>G	ENST00000408964.2	+	1	1593	c.1542A>G	c.(1540-1542)aaA>aaG	p.K514K		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	514										breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					AATCTGTGAAAGTGACCCCTG	0.418000													50	101					0	0	1	0	0
FAM83G	644815	broad.mit.edu	37	17	18907093	18907093	+	Missense_Mutation	SNP	G	G	C			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr17:18907093G>C	ENST00000388995.6	-	2	485	c.262C>G	c.(262-264)Cag>Gag	p.Q88E	SLC5A10_ENST00000395642.1_Intron|SLC5A10_ENST00000417251.2_Intron|SLC5A10_ENST00000317977.6_Intron|SLC5A10_ENST00000395643.2_Intron|SLC5A10_ENST00000395647.2_Intron|SLC5A10_ENST00000395645.3_Intron|FAM83G_ENST00000585154.2_Missense_Mutation_p.Q88E|FAM83G_ENST00000345041.4_Missense_Mutation_p.Q88E			A6ND36	FA83G_HUMAN	family with sequence similarity 83, member G	88										central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|prostate(3)|stomach(1)	22						TCGGGCCCCTGAGAGGGGCCC	0.701000													6	24					0	0	1	0	0
LVRN	206338	broad.mit.edu	37	5	115298372	115298372	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr5:115298372G>T	ENST00000357872.4	+	1	182	c.58G>T	c.(58-60)Gct>Tct	p.A20S	AQPEP_ENST00000395528.2_5'UTR	NM_173800.4	NP_776161.3	Q6Q4G3	AMPQ_HUMAN		20					proteolysis	integral to membrane	metallopeptidase activity|zinc ion binding										CCTGCTGCTGGCTGGGCTGGT	0.701000													6	43					6.72482e-11	8.11617e-11	1	1	0
FANCM	57697	broad.mit.edu	37	14	45654507	45654507	+	Missense_Mutation	SNP	G	G	C			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr14:45654507G>C	ENST00000267430.5	+	18	4688	c.4603G>C	c.(4603-4605)Gaa>Caa	p.E1535Q	FANCM_ENST00000555013.1_3'UTR|FANCM_ENST00000542564.2_Missense_Mutation_p.E1509Q	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1535					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						TGATGAGTCAGAAAATGAACA	0.299000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				5	23					0	0	1	0	0
DDX20	11218	broad.mit.edu	37	1	112298676	112298676	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:112298676C>G	ENST00000369702.4	+	1	750	c.130C>G	c.(130-132)Cag>Gag	p.Q44E	DDX20_ENST00000536167.1_Missense_Mutation_p.Q44E	NM_007204.4	NP_009135.4	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	44					assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			endometrium(3)|kidney(7)|large_intestine(6)|lung(3)|pancreas(1)|prostate(1)	21		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCGGACCGCTCAGGATCTCAG	0.692000													3	21					0	0	1	0	0
TMEM131	23505	broad.mit.edu	37	2	98378573	98378573	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr2:98378573G>A	ENST00000186436.5	-	36	5042	c.4814C>T	c.(4813-4815)cCg>cTg	p.P1605L		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	1605						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						TGGGGGAGACGGGGAAGCAGG	0.547000													13	34					0	0	1	0	0
CARS2	79587	broad.mit.edu	37	13	111329336	111329336	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr13:111329336C>A	ENST00000257347.4	-	7	833	c.770G>T	c.(769-771)tGc>tTc	p.C257F	CARS2_ENST00000535398.1_5'UTR	NM_024537.2	NP_078813.1	Q9HA77	SYCM_HUMAN	cysteinyl-tRNA synthetase 2, mitochondrial (putative)	257					cysteinyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|cysteine-tRNA ligase activity|metal ion binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)|prostate(4)|skin(1)	13	all_lung(23;3.61e-05)|Lung NSC(43;0.00144)|Lung SC(71;0.0753)|all_neural(89;0.077)|Medulloblastoma(90;0.148)		BRCA - Breast invasive adenocarcinoma(86;0.163)		L-Cysteine(DB00151)	GATGGCAGAGCACTCGATGTG	0.662000													17	85					2.23348e-06	2.46488e-06	1	1	0
PRSS3P2	154754	broad.mit.edu	37	7	142481789	142481789	+	RNA	SNP	T	T	C	rs140267598	by1000genomes	TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr7:142481789T>C	ENST00000603901.1	+	0	468					NR_001296.3																						ACTACCCAGATGAGCTGCAGT	0.488000													8	51					0	0	1	0	0
DNMT3A	1788	broad.mit.edu	37	2	25457243	25457243	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr2:25457243G>A	ENST00000264709.3	-	23	2981	c.2644C>T	c.(2644-2646)Cgc>Tgc	p.R882C	DNMT3A_ENST00000402667.1_Missense_Mutation_p.R659C|DNMT3A_ENST00000321117.5_Missense_Mutation_p.R882C|DNMT3A_ENST00000380746.4_Missense_Mutation_p.R693C	NM_175629.2	NP_783328.1	Q9Y6K1	DNM3A_HUMAN	DNA (cytosine-5-)-methyltransferase 3 alpha	882					regulation of gene expression by genetic imprinting	cytoplasm|euchromatin|nuclear matrix	DNA (cytosine-5-)-methyltransferase activity|DNA binding|metal ion binding|protein binding	p.R882C(93)|p.R882S(8)		breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(964)|kidney(3)|large_intestine(10)|lung(29)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	1021	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCGCCAAGCGGCTCATGTTG	0.597000			"""Mis, F, N, S"""		AML								4	70					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100678341	100678341	+	Missense_Mutation	SNP	G	G	C			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr7:100678341G>C	ENST00000306151.4	+	3	3708	c.3644G>C	c.(3643-3645)gGa>gCa	p.G1215A		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1215	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TCAACTCCTGGAGAAAGAAGC	0.517000													59	696					0	0	1	0	0
WDR90	197335	broad.mit.edu	37	16	706454	706454	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr16:706454G>T	ENST00000549091.1	+	18	2211	c.2119G>T	c.(2119-2121)Gcc>Tcc	p.A707S	WDR90_ENST00000293879.4_Missense_Mutation_p.A707S	NM_145294.4	NP_660337.3	Q96KV7	WDR90_HUMAN	WD repeat domain 90	707										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				GTTGGCCCTCGCCATGGAGCA	0.701000													2	10					0.0784	0.0797012	1	1	0
FOCAD	54914	broad.mit.edu	37	9	20789607	20789607	+	Splice_Site	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr9:20789607G>T	ENST00000380249.1	+	13	1819	c.1455_splice	c.e13+1	p.Q485_splice	FOCAD_ENST00000338382.6_Splice_Site_p.Q485_splice	NM_017794.3	NP_060264.3	Q5VW36	K1797_HUMAN	focadhesin	485						integral to membrane	binding										ATTCCTCCCAGGTAAAGCAAG	0.383000													33	65					2.48696e-23	3.27583e-23	1	1	0
CKAP4	10970	broad.mit.edu	37	12	106633263	106633263	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr12:106633263C>A	ENST00000378026.4	-	2	1484	c.1348G>T	c.(1348-1350)Gcc>Tcc	p.A450S		NM_006825.3	NP_006816.2	Q07065	CKAP4_HUMAN	cytoskeleton-associated protein 4	450						ER-Golgi intermediate compartment membrane|integral to membrane|membrane fraction				NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|pancreas(1)|urinary_tract(1)	20						CCCTGCAGGGCGGCCAGGCGC	0.692000													20	61					5.35267e-07	5.96092e-07	1	1	0
MUC16	94025	broad.mit.edu	37	19	9076273	9076273	+	Silent	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr19:9076273G>A	ENST00000397910.4	-	3	11376	c.11173C>T	c.(11173-11175)Ctg>Ttg	p.L3725L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3726	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAAGTGGACAGGGGCGTATTT	0.493000													53	78					0	0	1	0	0
ACAP3	116983	broad.mit.edu	37	1	1235383	1235383	+	Silent	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:1235383C>A	ENST00000354700.5	-	8	835	c.633G>T	c.(631-633)ctG>ctT	p.L211L	ACAP3_ENST00000353662.3_Silent_p.L169L	NM_030649.2	NP_085152.2	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	211					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			endometrium(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	14						TGTAGGGGTCCAGCTGGTGCA	0.647000													18	21					1.56452e-12	1.92617e-12	1	1	0
ISCA1	81689	broad.mit.edu	37	9	88887029	88887029	+	Splice_Site	SNP	T	T	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr9:88887029T>G	ENST00000375991.4	-	3	206		c.e3-2		ISCA1_ENST00000452279.2_Splice_Site|ISCA1_ENST00000311534.6_Splice_Site|ISCA1_ENST00000326094.4_Splice_Site	NM_030940.3	NP_112202.2	Q9BUE6	ISCA1_HUMAN	iron-sulfur cluster assembly 1						iron-sulfur cluster assembly	mitochondrion	iron-sulfur cluster binding|metal ion binding|structural molecule activity			endometrium(2)|large_intestine(1)|lung(4)|pancreas(1)	8				OV - Ovarian serous cystadenocarcinoma(323;5.4e-34)|Lung(182;0.0375)		TACACCTACCTGAAAAAGAAG	0.343000													19	78					0	0	1	0	0
GAPVD1	26130	broad.mit.edu	37	9	128099631	128099631	+	Missense_Mutation	SNP	A	A	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr9:128099631A>T	ENST00000470056.1	+	15	2798	c.2638A>T	c.(2638-2640)Act>Tct	p.T880S	GAPVD1_ENST00000312123.9_Missense_Mutation_p.T859S|GAPVD1_ENST00000394104.2_Missense_Mutation_p.T880S|GAPVD1_ENST00000495955.1_Missense_Mutation_p.T880S|GAPVD1_ENST00000394105.2_Missense_Mutation_p.T907S|GAPVD1_ENST00000265956.4_Missense_Mutation_p.T854S|GAPVD1_ENST00000297933.6_Missense_Mutation_p.T880S|GAPVD1_ENST00000394083.2_Missense_Mutation_p.T859S			Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	880					endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						ccatgttttaactccagctga	0.502000													33	64					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95483458	95483458	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr12:95483458G>A	ENST00000343958.4	-	18	4088	c.3865C>T	c.(3865-3867)Cct>Tct	p.P1289S	FGD6_ENST00000546711.1_Missense_Mutation_p.P1289S	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	1289					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						CCAATCCTAGGGGAGTGCTGG	0.403000													70	161					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141734094	141734094	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr7:141734094C>G	ENST00000475668.2	+	15	1756	c.1702C>G	c.(1702-1704)Ctc>Gtc	p.L568V	MGAM_ENST00000549489.2_Missense_Mutation_p.L568V			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	568	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTGCAAGACTCTCTGTATGGA	0.488000													3	12					0	0	1	0	0
UBQLN3	50613	broad.mit.edu	37	11	5530488	5530488	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:5530488C>T	ENST00000311659.4	-	2	448	c.301G>A	c.(301-303)Gag>Aag	p.E101K	HBG2_ENST00000380259.2_Intron	NM_017481.2	NP_059509.1	Q9H347	UBQL3_HUMAN	ubiquilin 3	101										NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|prostate(1)|skin(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.74e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTGGGCACTCATTGCCCATG	0.587000													17	65					0	0	1	0	0
TMEM104	54868	broad.mit.edu	37	17	72832527	72832527	+	Missense_Mutation	SNP	G	G	C			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr17:72832527G>C	ENST00000335464.5	+	10	1354	c.1192G>C	c.(1192-1194)Gtc>Ctc	p.V398L	TMEM104_ENST00000417024.2_Intron|TMEM104_ENST00000582330.1_Missense_Mutation_p.V398L|TMEM104_ENST00000582773.1_Intron	NM_017728.3	NP_060198.3	Q8NE00	TM104_HUMAN	transmembrane protein 104	398						integral to membrane				NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(8)|lung(5)|ovary(1)	19	all_lung(278;0.23)					GGTGGACCGCGTCGTGTTTCC	0.652000													21	90					0	0	1	0	0
HOXA13	3209	broad.mit.edu	37	7	27239096	27239096	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr7:27239096C>A	ENST00000222753.4	-	1	629	c.601G>T	c.(601-603)Gcc>Tcc	p.A201S	HOTTIP_ENST00000421733.1_RNA	NM_000522.4	NP_000513.2	P31271	HXA13_HUMAN	homeobox A13	201	Poly-Ala.				skeletal system development	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)	6						gcggcggcggcggccgaggcg	0.706000			T	NUP98	AML								6	26					5.9392e-07	6.58418e-07	1	1	0
GTF3C1	2975	broad.mit.edu	37	16	27481533	27481533	+	Silent	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr16:27481533G>A	ENST00000356183.4	-	31	4725	c.4710C>T	c.(4708-4710)gcC>gcT	p.A1570A	GTF3C1_ENST00000561623.1_Silent_p.A1570A	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1570						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GGGTCAGGACGGCCACACAAT	0.522000													27	156					0	0	1	0	0
OR8K5	219453	broad.mit.edu	37	11	55927292	55927292	+	Missense_Mutation	SNP	A	A	C			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:55927292A>C	ENST00000313447.1	-	1	501	c.502T>G	c.(502-504)Ttc>Gtc	p.F168V		NM_001004058.2	NP_001004058.2	Q8NH50	OR8K5_HUMAN	olfactory receptor, family 8, subfamily K, member 5	168					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(24)|ovary(2)|pancreas(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	34	Esophageal squamous(21;0.00693)	Lung NSC(402;0.197)|all_epithelial(135;0.236)				GAGCCACAGAAGGTCAATGTA	0.383000													6	133					0	0	1	0	0
ZFP36	7538	broad.mit.edu	37	19	39898886	39898886	+	Silent	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr19:39898886C>G	ENST00000597629.1	+	2	620	c.546C>G	c.(544-546)ggC>ggG	p.G182G	ZFP36_ENST00000248673.3_Silent_p.G176G			P26651	TTP_HUMAN	ZFP36 ring finger protein	176					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			large_intestine(1)|lung(5)|pancreas(1)	7	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CGGCCCCGGGCCACCCTCCTG	0.672000													32	135					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11132545	11132545	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr19:11132545C>T	ENST00000358026.2	+	19	3045	c.2761C>T	c.(2761-2763)Ctc>Ttc	p.L921F	SMARCA4_ENST00000589677.1_Missense_Mutation_p.L921F|SMARCA4_ENST00000413806.3_Missense_Mutation_p.L921F|SMARCA4_ENST00000590574.1_Missense_Mutation_p.L921F|SMARCA4_ENST00000541122.2_Missense_Mutation_p.L921F|SMARCA4_ENST00000444061.3_Missense_Mutation_p.L921F|SMARCA4_ENST00000450717.3_Missense_Mutation_p.L921F|SMARCA4_ENST00000429416.3_Missense_Mutation_p.L921F|SMARCA4_ENST00000344626.4_Missense_Mutation_p.L921F	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	921	Helicase ATP-binding.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GCTTCCCGAGCTCTGGGCGCT	0.607000			"""F, N, Mis"""		NSCLC								14	37					0	0	1	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47591392	47591392	+	Silent	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr20:47591392C>T	ENST00000371917.4	+	13	1755	c.1755C>T	c.(1753-1755)ccC>ccT	p.P585P		NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	585					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			ATGTGAATCCCAACCACCAGA	0.522000													9	29					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801588	185801588	+	Nonsense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr2:185801588C>T	ENST00000302277.6	+	4	2059	c.1465C>T	c.(1465-1467)Cag>Tag	p.Q489*		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	489						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TCAGCAGAAGCAGGAAGACAT	0.343000													55	170					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153694503	153694503	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chrX:153694503G>A	ENST00000369682.3	+	15	2864	c.2689G>A	c.(2689-2691)Gag>Aag	p.E897K		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	897	IPT/TIG 1.				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GATCGTGTGTGAGATGGAGGA	0.667000													20	13					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108170486	108170486	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:108170486C>G	ENST00000278616.4	+	34	5436	c.5051C>G	c.(5050-5052)tCt>tGt	p.S1684C	ATM_ENST00000452508.2_Missense_Mutation_p.S1684C	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	1684					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.F1683fs*7(1)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		ATAGATTTCTCTACCATAGCT	0.368000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			78	102					0	0	1	0	0
BEND7	222389	broad.mit.edu	37	10	13541911	13541911	+	Silent	SNP	G	G	A	rs148828275	byFrequency	TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr10:13541911G>A	ENST00000341083.3	-	3	455	c.159C>T	c.(157-159)gcC>gcT	p.A53A	BEND7_ENST00000396900.2_Silent_p.A105A|BEND7_ENST00000378605.3_Silent_p.A53A|BEND7_ENST00000396898.2_Silent_p.A105A	NM_152751.2	NP_689964.2	Q8N7W2	BEND7_HUMAN	BEN domain containing 7	105							protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(2)|ovary(2)|prostate(1)|stomach(1)	17						GGCTTTGCGGGGCCTCAGCAG	0.552000													42	71					0	0	1	0	0
BBS4	585	broad.mit.edu	37	15	73022005	73022005	+	Missense_Mutation	SNP	T	T	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr15:73022005T>A	ENST00000268057.4	+	10	732	c.691T>A	c.(691-693)Tat>Aat	p.Y231N	BBS4_ENST00000542334.1_Missense_Mutation_p.Y59N|BBS4_ENST00000395205.2_Missense_Mutation_p.Y239N|BBS4_ENST00000539603.1_Missense_Mutation_p.Y219N	NM_033028.4	NP_149017.2	Q96RK4	BBS4_HUMAN	Bardet-Biedl syndrome 4	231	Interaction with PCM1.				adult behavior|brain morphogenesis|cell cycle cytokinesis|centrosome organization|cerebral cortex development|convergent extension involved in gastrulation|dendrite development|fat cell differentiation|heart looping|hippocampus development|intracellular transport|maintenance of protein location in nucleus|melanosome transport|microtubule anchoring at centrosome|neural tube closure|nonmotile primary cilium assembly|photoreceptor cell maintenance|pigment granule aggregation in cell center|positive regulation of flagellum assembly|regulation of cilium beat frequency involved in ciliary motility|regulation of cytokinesis|regulation of lipid metabolic process|retina homeostasis|retinal rod cell development|sensory perception of smell|sensory processing|spermatid development|striatum development	BBSome|centriolar satellite|centriole|cilium membrane|microtubule basal body|motile cilium|nonmotile primary cilium|nucleus|pericentriolar material	alpha-tubulin binding|beta-tubulin binding|dynactin binding|microtubule motor activity			autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|prostate(2)|urinary_tract(1)	19						TGCACTGACTTATGACCCTAC	0.458000									Bardet-Biedl syndrome				27	109					0	0	1	0	0
MEGF8	1954	broad.mit.edu	37	19	42860128	42860128	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr19:42860128G>T	ENST00000334370.4	+	23	4797	c.4162G>T	c.(4162-4164)Gcc>Tcc	p.A1388S	MEGF8_ENST00000251268.6_Missense_Mutation_p.A1455S	NM_001410.2	NP_001401.2	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	1455	CUB 2.					integral to membrane	calcium ion binding|structural molecule activity			breast(2)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(20)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	50		Prostate(69;0.00682)				GAACTGCAATGCCCACACTGG	0.642000													3	28					1	1	1	1	0
TYK2	7297	broad.mit.edu	37	19	10468715	10468715	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr19:10468715C>T	ENST00000525621.1	-	16	2756	c.2275G>A	c.(2275-2277)Gat>Aat	p.D759N	TYK2_ENST00000264818.6_Missense_Mutation_p.D759N|TYK2_ENST00000529370.1_Missense_Mutation_p.D759N|TYK2_ENST00000524462.1_Missense_Mutation_p.D574N	NM_003331.4	NP_003322.3	P29597	TYK2_HUMAN	tyrosine kinase 2	759	Protein kinase 1.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(11)|kidney(6)|large_intestine(3)|lung(19)|ovary(4)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			ACGCCAGGATCACTCAGCTTG	0.637000													8	30					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55933888	55933888	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr6:55933888C>A	ENST00000244728.5	-	22	2444	c.2047G>T	c.(2047-2049)Gga>Tga	p.G683*	COL21A1_ENST00000370808.2_Nonsense_Mutation_p.G83*|COL21A1_ENST00000370819.1_Nonsense_Mutation_p.G680*|COL21A1_ENST00000535941.1_Nonsense_Mutation_p.G683*|COL21A1_ENST00000467045.1_5'UTR	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	683	Collagen-like 4.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CCTGGTTCTCCTGGGGAACCC	0.423000													3	19					0.150653	0.151271	1	1	0
ADAMTSL1	92949	broad.mit.edu	37	9	18829862	18829862	+	Missense_Mutation	SNP	A	A	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr9:18829862A>T	ENST00000380548.4	+	23	4475	c.4136A>T	c.(4135-4137)cAg>cTg	p.Q1379L	ADAMTSL1_ENST00000380545.5_Missense_Mutation_p.Q80L	NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1379						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		GTCCCCACACAGTTGGAAGAC	0.572000													16	39					0	0	1	0	0
KBTBD8	84541	broad.mit.edu	37	3	67054205	67054205	+	Missense_Mutation	SNP	A	A	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr3:67054205A>T	ENST00000295568.4	+	3	867	c.736A>T	c.(736-738)Aac>Tac	p.N246Y	KBTBD8_ENST00000460576.1_Intron|KBTBD8_ENST00000417314.2_Missense_Mutation_p.N272Y|KBTBD8_ENST00000469661.1_3'UTR	NM_032505.2	NP_115894.2	Q8NFY9	KBTB8_HUMAN	kelch repeat and BTB (POZ) domain containing 8	272	BACK.									breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)	20		Lung NSC(201;0.0765)		BRCA - Breast invasive adenocarcinoma(55;6.02e-06)|KIRC - Kidney renal clear cell carcinoma(39;0.105)|Kidney(39;0.125)		GGGACCATCCAACACCAATGG	0.433000													52	143					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130218912	130218912	+	Silent	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chrX:130218912C>T	ENST00000276211.5	+	7	1174	c.829C>T	c.(829-831)Ctg>Ttg	p.L277L	ARHGAP36_ENST00000370922.1_Silent_p.L265L|ARHGAP36_ENST00000370921.1_Silent_p.L141L	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	277	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						TGATCAAGGTCTGGATGTAGT	0.493000													68	72					0	0	1	0	0
FCHO1	23149	broad.mit.edu	37	19	17895613	17895613	+	Nonsense_Mutation	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr19:17895613C>G	ENST00000594202.1	+	26	2585	c.2306C>G	c.(2305-2307)tCa>tGa	p.S769*	FCHO1_ENST00000600676.1_Nonsense_Mutation_p.S769*|FCHO1_ENST00000539407.1_Nonsense_Mutation_p.S769*|FCHO1_ENST00000596536.1_Nonsense_Mutation_p.S769*|FCHO1_ENST00000595033.1_Nonsense_Mutation_p.S719*|FCHO1_ENST00000597512.1_Nonsense_Mutation_p.S776*|FCHO1_ENST00000252771.7_Nonsense_Mutation_p.S769*|FCHO1_ENST00000389133.4_Nonsense_Mutation_p.S769*|FCHO1_ENST00000596951.1_Nonsense_Mutation_p.S769*	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	769										NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						ACCCAGGTCTCAGTGGAGTAC	0.642000											OREG0025350	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	150					0	0	1	0	0
ZNF521	25925	broad.mit.edu	37	18	22807071	22807071	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr18:22807071C>A	ENST00000361524.3	-	4	959	c.811G>T	c.(811-813)Gaa>Taa	p.E271*	ZNF521_ENST00000538137.2_Nonsense_Mutation_p.E271*|ZNF521_ENST00000584787.1_Nonsense_Mutation_p.E51*	NM_015461.2	NP_056276.1	Q96K83	ZN521_HUMAN	zinc finger protein 521	271					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(21)|lung(97)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	149	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					GGGGAGCATTCGGGGTGGCAC	0.557000			T	PAX5	ALL								36	50					2.20474e-14	2.77005e-14	1	1	0
MYO1D	4642	broad.mit.edu	37	17	31107652	31107652	+	Silent	SNP	C	C	T	rs142146727	by1000genomes	TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr17:31107652C>T	ENST00000318217.5	-	2	550	c.246G>A	c.(244-246)gcG>gcA	p.A82A	MYO1D_ENST00000394649.4_5'UTR|MYO1D_ENST00000579584.1_Silent_p.A82A|MYO1D_ENST00000583621.1_Silent_p.A82A	NM_015194.1	NP_056009.1	O94832	MYO1D_HUMAN	myosin ID	82	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39			BRCA - Breast invasive adenocarcinoma(9;0.0362)			AAGCAGCATCCGCAATAGCAA	0.438000													31	88					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363874	22363874	+	Silent	SNP	A	A	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr19:22363874A>G	ENST00000397121.2	-	3	962	c.645T>C	c.(643-645)caT>caC	p.H215H		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	215				KFSILTKHKVIHT -> WSSSLTEHKRIHA (in Ref. 2; BAC05174).	regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				GAATTACCTTATGTTTAGTAA	0.343000													23	82					0	0	1	0	0
KIAA0922	23240	broad.mit.edu	37	4	154542918	154542918	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr4:154542918G>T	ENST00000409663.3	+	28	3825	c.3773G>T	c.(3772-3774)tGg>tTg	p.W1258L	KIAA0922_ENST00000409959.3_Missense_Mutation_p.W1259L|KIAA0922_ENST00000440693.1_Missense_Mutation_p.W1175L	NM_015196.3	NP_056011.3	A2VDJ0	T131L_HUMAN	KIAA0922	1258						integral to membrane				breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(16)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	63	all_hematologic(180;0.093)	Renal(120;0.118)				GTAAGAAGCTGGTGTATACAG	0.468000													23	59					3.83957e-06	4.18086e-06	1	1	0
DMXL2	23312	broad.mit.edu	37	15	51791155	51791155	+	Silent	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr15:51791155C>T	ENST00000251076.5	-	18	4553	c.4266G>A	c.(4264-4266)gaG>gaA	p.E1422E	DMXL2_ENST00000449909.3_Intron|DMXL2_ENST00000543779.2_Silent_p.E1422E	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1422						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		TAGAATCTATCTCAGTATAAT	0.403000													11	227					0	0	1	0	0
UTP20	27340	broad.mit.edu	37	12	101706034	101706034	+	Silent	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr12:101706034G>A	ENST00000261637.4	+	21	2706	c.2532G>A	c.(2530-2532)ccG>ccA	p.P844P		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	844					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding	p.P844P(1)		NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						AGCTTTCCCCGCTTTTCTTGA	0.468000													36	112					0	0	1	0	0
OR2T11	127077	broad.mit.edu	37	1	248789800	248789800	+	Missense_Mutation	SNP	G	G	C			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:248789800G>C	ENST00000330803.2	-	1	691	c.630C>G	c.(628-630)atC>atG	p.I210M		NM_001001964.1	NP_001001964.1	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T, member 11 (gene/pseudogene)	210					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(20)|skin(2)	28	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAGTGGAGATGATAGAGATGG	0.502000													10	163					0	0	1	0	0
SH2D2A	9047	broad.mit.edu	37	1	156777073	156777073	+	Missense_Mutation	SNP	T	T	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:156777073T>G	ENST00000392306.2	-	8	1236	c.1097A>C	c.(1096-1098)cAc>cCc	p.H366P	SH2D2A_ENST00000368199.3_Missense_Mutation_p.H356P|SH2D2A_ENST00000368198.3_Missense_Mutation_p.H338P	NM_001161441.1	NP_001154913.1	Q9NP31	SH22A_HUMAN	SH2 domain containing 2A	356	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity			endometrium(1)|large_intestine(2)|lung(15)	18	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					TGGGGGCTGGTGGGGCAGGGG	0.597000													4	18					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114278688	114278688	+	Missense_Mutation	SNP	G	G	T	rs140076489		TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr4:114278688G>T	ENST00000357077.4	+	38	8967	c.8914G>T	c.(8914-8916)Gta>Tta	p.V2972L	ANK2_ENST00000510275.2_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.V2939L	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2939					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		TGAAGACGTTGTAGTGGCAAG	0.413000													80	235					1.75807e-36	2.36663e-36	1	1	0
LNP1	348801	broad.mit.edu	37	3	100170641	100170641	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr3:100170641C>G	ENST00000383693.3	+	3	1515	c.235C>G	c.(235-237)Cgt>Ggt	p.R79G	LNP1_ENST00000489752.1_Missense_Mutation_p.R92G	NM_001085451.1	NP_001078920.1	A1A4G5	LNP1_HUMAN	leukemia NUP98 fusion partner 1	79										cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	6						ATTTCGATGCCGTAGCCACGT	0.428000													29	86					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:142713774A>G	ENST00000369381.2	-	0	831																											CTTTTTCCACATTGTCATTTT	0.284000													8	100					0	0	1	0	0
STAB1	23166	broad.mit.edu	37	3	52536021	52536021	+	Splice_Site	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr3:52536021G>A	ENST00000321725.6	+	4	407		c.e4-1			NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1						cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GGGGTCCACAGAATGCCCTGG	0.642000													12	62					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168100900	168100900	+	Nonsense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr2:168100900C>T	ENST00000409195.1	+	9	3087	c.2998C>T	c.(2998-3000)Caa>Taa	p.Q1000*	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000295237.9_Nonsense_Mutation_p.Q1000*|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000409273.1_Nonsense_Mutation_p.Q778*|XIRP2_ENST00000420519.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	825					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AAAATATCATCAAGTAAAGAC	0.413000													21	108					0	0	1	0	0
ACAP3	116983	broad.mit.edu	37	1	1235384	1235384	+	Missense_Mutation	SNP	A	A	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:1235384A>G	ENST00000354700.5	-	8	834	c.632T>C	c.(631-633)cTg>cCg	p.L211P	ACAP3_ENST00000353662.3_Missense_Mutation_p.L169P	NM_030649.2	NP_085152.2	Q96P50	ACAP3_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 3	211					filopodium assembly|regulation of ARF GTPase activity|signal transduction		ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			endometrium(3)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	14						GTAGGGGTCCAGCTGGTGCAG	0.647000													19	21					0	0	1	0	0
CYLC2	1539	broad.mit.edu	37	9	105757672	105757672	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr9:105757672C>A	ENST00000374798.3	+	1	80	c.10C>A	c.(10-12)Cca>Aca	p.P4T	CYLC2_ENST00000487798.1_Missense_Mutation_p.P4T	NM_001340.3	NP_001331.1	Q14093	CYLC2_HUMAN	cylicin, basic protein of sperm head cytoskeleton 2	4					cell differentiation|multicellular organismal development|spermatogenesis	cytoskeletal calyx	structural constituent of cytoskeleton			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(14)|ovary(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(2)	41		all_hematologic(171;0.125)				AATGTCTCTCCCAAGATTGTA	0.303000													27	132					4.87955e-14	6.09944e-14	1	1	0
KRT6B	3854	broad.mit.edu	37	12	52842748	52842748	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr12:52842748C>A	ENST00000252252.3	-	6	1128	c.1081G>T	c.(1081-1083)Gag>Tag	p.E361*		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	361	Coil 2.|Rod.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		TGCAGCTCCTCGTACTGCAGC	0.532000													10	34					7.03913e-09	8.17339e-09	1	1	0
FLII	2314	broad.mit.edu	37	17	18155795	18155795	+	Silent	SNP	C	C	T	rs148245851	byFrequency	TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr17:18155795C>T	ENST00000327031.4	-	10	1314	c.1089G>A	c.(1087-1089)acG>acA	p.T363T	FLII_ENST00000545457.2_Silent_p.T309T|FLII_ENST00000379450.4_Silent_p.T278T|FLII_ENST00000579294.1_Silent_p.T352T|FLII_ENST00000578558.1_Silent_p.T363T	NM_002018.3	NP_002009.1	Q13045	FLII_HUMAN	flightless I homolog (Drosophila)	363	Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32	all_neural(463;0.228)					CCTCGATCTCCGTCAGGAAAT	0.597000													17	67					0	0	1	0	0
ABI3	51225	broad.mit.edu	37	17	47294040	47294040	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr17:47294040C>T	ENST00000225941.1	+	2	763	c.265C>T	c.(265-267)Cgt>Tgt	p.R89C	ABI3_ENST00000419580.2_Missense_Mutation_p.R89C	NM_001135186.1|NM_016428.2	NP_001128658.1|NP_057512.1	Q9P2A4	ABI3_HUMAN	ABI family, member 3	89					cellular component movement|regulation of cell migration	cytoplasm|lamellipodium	protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	12			Epithelial(5;6.37e-06)|all cancers(6;6.36e-05)			GGTGGAAGCCCGTGTAAGCAC	0.642000										HNSCC(55;0.14)			5	20					0	0	1	0	0
ATN1	1822	broad.mit.edu	37	12	7048196	7048196	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr12:7048196G>A	ENST00000356654.4	+	7	3307	c.3070G>A	c.(3070-3072)Gag>Aag	p.E1024K	ATN1_ENST00000396684.2_Missense_Mutation_p.E1024K	NM_001007026.1	NP_001007027.1	P54259	ATN1_HUMAN	atrophin 1	1024					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			breast(5)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	40						GCTGGCAGCTGAGAGGCAGCA	0.652000													22	74					0	0	1	0	0
WWP2	11060	broad.mit.edu	37	16	69965411	69965411	+	Splice_Site	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr16:69965411G>A	ENST00000359154.2	+	15	1622		c.e15-1		WWP2_ENST00000448661.1_Splice_Site|WWP2_ENST00000356003.2_Splice_Site|WWP2_ENST00000542271.1_Splice_Site|WWP2_ENST00000544162.1_Splice_Site|WWP2_ENST00000568684.1_Splice_Site	NM_001270454.1|NM_007014.4	NP_001257383.1|NP_008945.2	O00308	WWP2_HUMAN	WW domain containing E3 ubiquitin protein ligase 2						entry of virus into host cell|negative regulation of protein transport|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transporter activity|proteasomal ubiquitin-dependent protein catabolic process|protein K63-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	RNA polymerase II transcription factor binding|ubiquitin-protein ligase activity			breast(4)|endometrium(2)|kidney(2)|large_intestine(11)|lung(13)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TTTTTTTTCAGTCAAATGCCC	0.483000													22	57					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215956231	215956231	+	Silent	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:215956231G>T	ENST00000366943.2	-	53	10820	c.10434C>A	c.(10432-10434)gcC>gcA	p.A3478A	USH2A_ENST00000307340.3_Silent_p.A3478A			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3478	Fibronectin type-III 19.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGCTGTTCCAGGCAGAAATCC	0.438000										HNSCC(13;0.011)			19	71					1.01871e-10	1.22345e-10	1	1	0
NEIL3	55247	broad.mit.edu	37	4	178274877	178274877	+	Silent	SNP	T	T	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr4:178274877T>A	ENST00000264596.3	+	8	1573	c.1455T>A	c.(1453-1455)tcT>tcA	p.S485S	RP11-376O6.2_ENST00000506895.1_RNA	NM_018248.2	NP_060718.2	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3 (E. coli)	485					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		CTGGATATTCTAACAGGTATG	0.363000								Base excision repair (BER), DNA glycosylases					18	77					0	0	1	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28217255	28217255	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr21:28217255C>T	ENST00000284984.2	-	1	473	c.19G>A	c.(19-21)Gag>Aag	p.E7K		NM_006988.3	NP_008919.3	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 1	7					integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(20)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	42		Breast(209;0.000962)		Lung(58;0.215)		CCGAACCCCTCGGGCACAGCT	0.677000											OREG0026151	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	25					0	0	1	0	0
TEAD4	7004	broad.mit.edu	37	12	3127715	3127715	+	Nonsense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr12:3127715G>A	ENST00000359864.2	+	7	678	c.488G>A	c.(487-489)tGg>tAg	p.W163*	TEAD4_ENST00000397122.2_Nonsense_Mutation_p.W34*|TEAD4_ENST00000358409.2_Nonsense_Mutation_p.W120*	NM_003213.3	NP_003204.2	Q15561	TEAD4_HUMAN	TEA domain family member 4	163					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			CCTCAGTTTTGGCAAGGAGCT	0.602000													26	66					0	0	1	0	0
RTEL1	51750	broad.mit.edu	37	20	62319326	62319326	+	Silent	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr20:62319326C>T	ENST00000318100.4	+	18	2345	c.1518C>T	c.(1516-1518)atC>atT	p.I506I	RTEL1_ENST00000360203.5_Silent_p.I506I|RTEL1_ENST00000370018.3_Silent_p.I506I|RTEL1-TNFRSF6B_ENST00000482936.1_Silent_p.I506I|RTEL1_ENST00000508582.2_Silent_p.I530I			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	506					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			CACACATCATCGACAAGCACC	0.647000													7	35					0	0	1	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17124229	17124229	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:17124229C>G	ENST00000265970.7	-	23	3830	c.3831G>C	c.(3829-3831)caG>caC	p.Q1277H	PIK3C2A_ENST00000540361.1_Missense_Mutation_p.Q897H|PIK3C2A_ENST00000531428.1_Intron	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	1277	PI3K/PI4K.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	TGCCAAACATCTGTGCATGTC	0.378000													36	109					0	0	1	0	0
SFT2D2	375035	broad.mit.edu	37	1	168211776	168211776	+	Nonstop_Mutation	SNP	T	T	C			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:168211776T>C	ENST00000271375.3	+	8	553	c.481T>C	c.(481-483)Taa>Caa	p.*161Q	SFT2D2_ENST00000367825.3_3'UTR	NM_199344.2	NP_955376.1	O95562	SFT2B_HUMAN	SFT2 domain containing 2	0					protein transport|vesicle-mediated transport	integral to membrane				lung(3)|skin(1)	4	all_hematologic(923;0.215)					GTGTCTTGCATAATTCATGGC	0.443000													49	212					0	0	1	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133653583	133653583	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr3:133653583C>T	ENST00000310926.4	-	14	2179	c.1906G>A	c.(1906-1908)Gtg>Atg	p.V636M	SLCO2A1_ENST00000493729.1_Missense_Mutation_p.V560M	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	636					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						GCCTTCTGCACGTTGTACTCC	0.582000													10	62					0	0	1	0	0
PIP4K2C	79837	broad.mit.edu	37	12	57994143	57994143	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr12:57994143C>G	ENST00000354947.5	+	7	752	c.736C>G	c.(736-738)Ctc>Gtc	p.L246V	PIP4K2C_ENST00000550465.1_Missense_Mutation_p.L228V|PIP4K2C_ENST00000540759.2_Missense_Mutation_p.L246V|PIP4K2C_ENST00000422156.3_Missense_Mutation_p.L198V			Q8TBX8	PI42C_HUMAN	phosphatidylinositol-5-phosphate 4-kinase, type II, gamma	246	PIPK.					cytoplasm|membrane	1-phosphatidylinositol-5-phosphate 4-kinase activity|ATP binding|identical protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(13)|pancreas(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Melanoma(17;0.122)					TATGGACTTTCTCAACAAGAA	0.428000													14	97					0	0	1	0	0
ZNF703	80139	broad.mit.edu	37	8	37555443	37555443	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr8:37555443G>A	ENST00000331569.4	+	2	1253	c.1024G>A	c.(1024-1026)Gtg>Atg	p.V342M		NM_025069.1	NP_079345.1	Q9H7S9	ZN703_HUMAN	zinc finger protein 703	342	Gly-rich.				adherens junction assembly|mammary gland epithelial cell differentiation|negative regulation of homotypic cell-cell adhesion|negative regulation of transcription, DNA-dependent|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of mammary gland epithelial cell proliferation|regulation of canonical Wnt receptor signaling pathway|regulation of cell cycle|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding		FGFR1/ZNF703(2)	breast(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(1)|pancreas(1)	7			BRCA - Breast invasive adenocarcinoma(5;7.93e-25)|LUSC - Lung squamous cell carcinoma(8;1.05e-09)			GTCCGGCCTCGTGGGAGGCCA	0.721000													3	7					0	0	1	0	0
ZNF225	7768	broad.mit.edu	37	19	44635501	44635501	+	Nonsense_Mutation	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr19:44635501C>G	ENST00000262894.6	+	5	1014	c.734C>G	c.(733-735)tCa>tGa	p.S245*	ZNF225_ENST00000590612.1_Nonsense_Mutation_p.S245*|ZNF225_ENST00000592780.1_3'UTR	NM_013362.2	NP_037494.2	Q9UK10	ZN225_HUMAN	zinc finger protein 225	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	16		Prostate(69;0.0352)|all_neural(266;0.202)				AGTCGTAGATCAGGACTTTAT	0.413000													33	138					0	0	1	0	0
KRTAP9-2	83899	broad.mit.edu	37	17	39383164	39383164	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr17:39383164C>A	ENST00000377721.3	+	1	265	c.258C>A	c.(256-258)tgC>tgA	p.C86*	KRTAP9-2_ENST00000455970.2_Intron	NM_031961.2	NP_114167.2	Q9BYQ4	KRA92_HUMAN	keratin associated protein 9-2	86	17 X 5 AA repeats of C-C-[RQVSGE]-[SPTQ]- [TASP].					keratin filament	protein binding			large_intestine(1)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	11		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			CACCCTGCTGCCAGCCCACCT	0.622000													25	54					8.4185e-14	1.04697e-13	1	1	0
DOCK2	1794	broad.mit.edu	37	5	169141073	169141073	+	Silent	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr5:169141073C>A	ENST00000256935.8	+	18	1781	c.1701C>A	c.(1699-1701)acC>acA	p.T567T	DOCK2_ENST00000540750.1_5'UTR|DOCK2_ENST00000520908.1_Silent_p.T59T	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	567	DHR-1.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CATACCTGACCCTTCCTTCTT	0.567000													19	80					1.28384e-07	1.43626e-07	1	1	0
DOCK10	55619	broad.mit.edu	37	2	225721646	225721646	+	Missense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr2:225721646G>A	ENST00000409592.3	-	15	1834	c.1721C>T	c.(1720-1722)cCa>cTa	p.P574L	DOCK10_ENST00000258390.7_Missense_Mutation_p.P580L			Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	580							GTP binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(10)|large_intestine(16)|lung(40)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	87		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TCTAAACAATGGTGAAAATCT	0.308000													15	33					0	0	1	0	0
TBC1D3P5	440419	broad.mit.edu	37	17	25749148	25749148	+	RNA	SNP	G	G	C			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr17:25749148G>C	ENST00000586223.1	+	0	1049					NR_033892.1																						TGTGACACCAGATCGTTTTCT	0.522000													7	25					0	0	1	0	0
PTPN14	5784	broad.mit.edu	37	1	214625225	214625225	+	Silent	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:214625225G>A	ENST00000366956.5	-	3	461	c.267C>T	c.(265-267)ttC>ttT	p.F89F	PTPN14_ENST00000543945.1_Silent_p.F89F	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	89	FERM.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		GCTCATTAGCGAATTTGTCCA	0.473000													30	93					0	0	1	0	0
SLITRK2	84631	broad.mit.edu	37	X	144904119	144904119	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chrX:144904119C>A	ENST00000370490.1	+	1	4431	c.176C>A	c.(175-177)cCc>cAc	p.P59H	SLITRK2_ENST00000413937.2_Missense_Mutation_p.P59H|SLITRK2_ENST00000434188.2_Missense_Mutation_p.P59H|SLITRK2_ENST00000447897.2_Missense_Mutation_p.P59H|SLITRK2_ENST00000428560.2_Missense_Mutation_p.P59H			Q9H156	SLIK2_HUMAN	SLIT and NTRK-like family, member 2	59						integral to membrane		p.P59H(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(17)|lung(40)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	86	Acute lymphoblastic leukemia(192;6.56e-05)					CTGCTCCAGCCCCCCCAGTAT	0.428000													7	49					5.18039e-06	5.61591e-06	1	1	0
PRLR	5618	broad.mit.edu	37	5	35084642	35084642	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr5:35084642C>T	ENST00000382002.5	-	5	729	c.303G>A	c.(301-303)atG>atA	p.M101I	PRLR_ENST00000342362.5_Intron|PRLR_ENST00000542609.1_Missense_Mutation_p.M101I|PRLR_ENST00000513753.1_Missense_Mutation_p.M101I|PRLR_ENST00000511486.1_Intron|PRLR_ENST00000509934.1_5'UTR|PRLR_ENST00000397391.3_Missense_Mutation_p.M30I|PRLR_ENST00000348262.3_Missense_Mutation_p.M101I|PRLR_ENST00000310101.5_Missense_Mutation_p.M101I|PRLR_ENST00000231423.3_Missense_Mutation_p.M101I	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	101	Fibronectin type-III 1.				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	CATTGACCATCATGATGTATG	0.483000													20	267					0	0	1	0	0
SDHAP1	255812	broad.mit.edu	37	3	195690117	195690117	+	RNA	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr3:195690117C>T	ENST00000427841.1	-	0	2325					NR_003264.2																						AGTGCAGAAGCGTATAAAGAC	0.463000													2	4					0	0	1	0	0
FAM160A2	84067	broad.mit.edu	37	11	6232909	6232909	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:6232909C>T	ENST00000265978.4	-	12	3146	c.2788G>A	c.(2788-2790)Ggt>Agt	p.G930S	FAM160A2_ENST00000449352.2_Missense_Mutation_p.G916S|FAM160A2_ENST00000529360.1_5'UTR	NM_001098794.1|NM_032127.3	NP_001092264.1|NP_115503.2	Q8N612	F16A2_HUMAN	family with sequence similarity 160, member A2	916					early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|protein transport	FHF complex	protein binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(7)|liver(1)|lung(14)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						AGAGCCTCACCTTGGCGTTCA	0.597000													25	82					0	0	1	0	0
DOK5	55816	broad.mit.edu	37	20	53205293	53205293	+	Silent	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr20:53205293C>A	ENST00000262593.5	+	4	707	c.357C>A	c.(355-357)atC>atA	p.I119I	DOK5_ENST00000395939.1_Silent_p.I11I	NM_018431.3	NP_060901.2	Q9P104	DOK5_HUMAN	docking protein 5	119							insulin receptor binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|skin(1)	19			Colorectal(105;0.202)			TCAATGACATCAGCCTTGGAG	0.448000													36	92					1.71298e-08	1.96112e-08	1	1	0
OR1A1	8383	broad.mit.edu	37	17	3119742	3119742	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr17:3119742C>A	ENST00000304094.1	+	1	828	c.828C>A	c.(826-828)taC>taA	p.Y276*		NM_014565.2	NP_055380.2	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A, member 1	276					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	23						CTGTAATGTACACGGCAGTGA	0.458000													41	168					4.01765e-15	5.07384e-15	1	1	0
RIPPLY2	134701	broad.mit.edu	37	6	84563439	84563439	+	Missense_Mutation	SNP	G	G	C			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr6:84563439G>C	ENST00000369689.1	+	2	272	c.121G>C	c.(121-123)Gtg>Ctg	p.V41L	RIPPLY2_ENST00000369687.1_5'UTR	NM_001009994.1	NP_001009994.1	Q5TAB7	RIPP2_HUMAN	ripply transcriptional repressor 2	41					somite rostral/caudal axis specification	nucleus				large_intestine(2)|lung(4)|urinary_tract(1)	7						GAGACCCTGGGTGGACGCCGG	0.677000													5	12					0	0	1	0	0
DYNLL1	8655	broad.mit.edu	37	12	120935938	120935938	+	Silent	SNP	T	T	C	rs142759655	byFrequency	TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr12:120935938T>C	ENST00000392509.2	+	3	456	c.195T>C	c.(193-195)taT>taC	p.Y65Y	DYNLL1_ENST00000242577.6_Silent_p.Y65Y|DYNLL1_ENST00000548342.1_Silent_p.Y65Y|DYNLL1_ENST00000552316.1_3'UTR|DYNLL1_ENST00000552870.1_3'UTR|DYNLL1_ENST00000549989.1_Silent_p.Y65Y|DYNLL1_ENST00000392508.2_Silent_p.Y65Y	NM_001037494.1	NP_001032583.1	P63167	DYL1_HUMAN	dynein, light chain, LC8-type 1	65					actin cytoskeleton organization|activation of pro-apoptotic gene products|anatomical structure morphogenesis|female gamete generation|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|microtubule-based process|negative regulation of phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	centrosome|cytoplasmic dynein complex|cytosol|microtubule|mitochondrion|nucleus|plasma membrane	motor activity|protein binding					all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCGGTAGTTATGTGACACATG	0.423000													22	62					0	0	1	0	0
MKL2	57496	broad.mit.edu	37	16	14342867	14342867	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr16:14342867G>T	ENST00000571589.1	+	13	2504	c.2332G>T	c.(2332-2334)Gcc>Tcc	p.A778S	MKL2_ENST00000318282.5_Missense_Mutation_p.A728S|MKL2_ENST00000574045.1_Missense_Mutation_p.A728S|MKL2_ENST00000341243.5_Missense_Mutation_p.A767S	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	767	Gln-rich.				cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						CTCAGGCTTGGCCCCAACTGT	0.502000													11	68					0.00185496	0.00193389	1	1	0
KCNJ2	3759	broad.mit.edu	37	17	68171491	68171491	+	Nonsense_Mutation	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr17:68171491G>A	ENST00000243457.3	+	2	694	c.311G>A	c.(310-312)tGg>tAg	p.W104*	KCNJ2_ENST00000535240.1_Nonsense_Mutation_p.W104*	NM_000891.2	NP_000882.1	P63252	IRK2_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 2	104					synaptic transmission	integral to plasma membrane	inward rectifier potassium channel activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(13)|skin(1)|urinary_tract(1)	25	Breast(10;1.64e-08)					TGTGTGTTTTGGTTGATAGCT	0.527000													38	124					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80053285	80053285	+	Missense_Mutation	SNP	A	A	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr17:80053285A>G	ENST00000306749.2	-	3	409	c.191T>C	c.(190-192)tTc>tCc	p.F64S		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	64	Beta-ketoacyl synthase (By similarity).				energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	GACTCCGAAGAAGGAGGCATC	0.622000													18	57					0	0	1	0	0
PGBD1	84547	broad.mit.edu	37	6	28269795	28269795	+	Nonsense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr6:28269795C>T	ENST00000405948.2	+	7	2584	c.2164C>T	c.(2164-2166)Cag>Tag	p.Q722*	PGBD1_ENST00000259883.3_Nonsense_Mutation_p.Q722*	NM_001184743.1|NM_032507.3	NP_001171672.1|NP_115896.1	Q96JS3	PGBD1_HUMAN	piggyBac transposable element derived 1	722					viral reproduction	membrane|nucleus	scavenger receptor activity|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	41						AGAAATCCCTCAGATAAGTCA	0.408000													39	133					0	0	1	0	0
ABLIM3	22885	broad.mit.edu	37	5	148620262	148620262	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr5:148620262C>A	ENST00000506113.1	+	13	1710	c.1228C>A	c.(1228-1230)Cca>Aca	p.P410T	ABLIM3_ENST00000326685.7_Intron|ABLIM3_ENST00000356541.3_Intron|ABLIM3_ENST00000508983.1_Intron|RP11-331K21.1_ENST00000522685.1_RNA|AC012613.2_ENST00000523176.1_RNA|ABLIM3_ENST00000504238.1_Intron|ABLIM3_ENST00000309868.7_Missense_Mutation_p.P410T|RP11-331K21.1_ENST00000512647.2_RNA			O94929	ABLM3_HUMAN	actin binding LIM protein family, member 3	410					axon guidance|cytoskeleton organization	cytoplasm	actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(13)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	34			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGGAGCTCTCCATACCATAG	0.562000													45	114					1.35964e-18	1.72596e-18	1	1	0
TTC14	151613	broad.mit.edu	37	3	180328061	180328061	+	Missense_Mutation	SNP	G	G	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr3:180328061G>T	ENST00000296015.4	+	12	2176	c.2044G>T	c.(2044-2046)Gtt>Ttt	p.V682F	TTC14_ENST00000382584.4_Intron|TTC14_ENST00000412756.2_3'UTR	NM_133462.3	NP_597719.1	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14	682							RNA binding			endometrium(3)|kidney(5)|large_intestine(9)|lung(24)|ovary(2)|pancreas(1)|skin(1)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TTGGAAGTCAGTTGAGAAATA	0.398000													36	92					3.21399e-22	4.18845e-22	1	1	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr19:58385762C>G	ENST00000435989.2	-	3	1230	c.996G>C	c.(994-996)tcG>tcC	p.S332S	ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000597832.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.S332S(2)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						ATTTGCTAAACGATTTCCCAC	0.358000													4	8					0	0	1	0	0
BRSK2	9024	broad.mit.edu	37	11	1462057	1462057	+	Silent	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:1462057C>T	ENST00000308219.9	+	4	698	c.312C>T	c.(310-312)ttC>ttT	p.F104F	BRSK2_ENST00000308230.5_Silent_p.F104F|BRSK2_ENST00000526678.1_Silent_p.F104F|BRSK2_ENST00000531197.1_Silent_p.F104F|BRSK2_ENST00000382179.1_Silent_p.F150F|BRSK2_ENST00000528710.1_Silent_p.F44F|BRSK2_ENST00000528841.1_Silent_p.F104F	NM_001256627.1|NM_003957.3	NP_001243556.1|NP_003948.2	Q8IWQ3	BRSK2_HUMAN	BR serine/threonine kinase 2	104	Protein kinase.				establishment of cell polarity|neuron differentiation		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			endometrium(4)|large_intestine(1)|lung(5)	10		all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00144)|Lung(200;0.0713)|LUSC - Lung squamous cell carcinoma(625;0.0842)		GTGAGCTCTTCGACTACCTGG	0.622000													3	7					0	0	1	0	0
DHX29	54505	broad.mit.edu	37	5	54557208	54557208	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr5:54557208C>A	ENST00000251636.5	-	25	4096	c.3948G>T	c.(3946-3948)tgG>tgT	p.W1316C	RP11-506H20.1_ENST00000506435.1_RNA	NM_019030.2	NP_061903.2	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	1316							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|lung(6)|ovary(4)|prostate(1)|skin(3)|urinary_tract(2)	46		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				GAAAATAGATCCAGCCATCAA	0.318000													29	103					3.73148e-12	4.57106e-12	1	1	0
SLC12A2	6558	broad.mit.edu	37	5	127471499	127471499	+	Splice_Site	SNP	A	A	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr5:127471499A>G	ENST00000262461.2	+	7	1596	c.1408_splice	c.e7+1	p.K469_splice	SLC12A2_ENST00000343225.4_Splice_Site_p.K469_splice	NM_001046.2	NP_001037.1	P55011	S12A2_HUMAN	solute carrier family 12 (sodium/potassium/chloride transporter), member 2	469					potassium ion transport|sodium ion transport|transepithelial ammonium transport|transepithelial chloride transport	integral to plasma membrane|membrane fraction	ammonia transmembrane transporter activity|sodium:potassium:chloride symporter activity			breast(3)|endometrium(5)|kidney(5)|large_intestine(12)|lung(16)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48		all_cancers(142;0.0972)|Prostate(80;0.151)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.0433)|OV - Ovarian serous cystadenocarcinoma(64;0.0978)	Bumetanide(DB00887)|Potassium Chloride(DB00761)	TTGGTTATAAATGTAAGTAAA	0.294000													14	45					0	0	1	0	0
SCUBE2	57758	broad.mit.edu	37	11	9077431	9077431	+	Missense_Mutation	SNP	C	C	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:9077431C>G	ENST00000457346.2	-	10	1190	c.1116G>C	c.(1114-1116)agG>agC	p.R372S	SCUBE2_ENST00000520467.1_Missense_Mutation_p.R372S|SCUBE2_ENST00000309263.3_Missense_Mutation_p.R372S|RP11-467K18.2_ENST00000531592.1_RNA|SCUBE2_ENST00000450649.2_Missense_Mutation_p.R372S			Q9NQ36	SCUB2_HUMAN	signal peptide, CUB domain, EGF-like 2	372	EGF-like 8; calcium-binding (Potential).					extracellular region	calcium ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(15)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		GGTCACAGGTCCTATCCAAAG	0.502000													44	114					0	0	1	0	0
SLC39A5	283375	broad.mit.edu	37	12	56631422	56631422	+	Silent	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr12:56631422C>T	ENST00000266980.4	+	11	1823	c.1530C>T	c.(1528-1530)ctC>ctT	p.L510L	SLC39A5_ENST00000454355.2_Silent_p.L510L|SLC39A5_ENST00000419232.1_3'UTR	NM_001135195.1	NP_001128667.1	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (zinc transporter), member 5	510					zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			NS(1)|cervix(6)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CCCATGTGCTCCTGCAGGGGC	0.647000													7	79					0	0	1	0	0
KRTAP19-5	337972	broad.mit.edu	37	21	31874354	31874354	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr21:31874354C>A	ENST00000334151.2	-	1	81	c.55G>T	c.(55-57)Gat>Tat	p.D19Y		NM_181611.1	NP_853642.1	Q3LI72	KR195_HUMAN	keratin associated protein 19-5	19						intermediate filament	protein binding			endometrium(1)|large_intestine(5)|lung(4)|pancreas(1)|prostate(1)	12						CCCAGGTCATCGAAGCCTCCG	0.587000													41	140					6.99958e-10	8.20525e-10	1	1	0
OR5L1	219437	broad.mit.edu	37	11	55579082	55579082	+	Missense_Mutation	SNP	C	C	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:55579082C>T	ENST00000333973.2	+	1	229	c.140C>T	c.(139-141)gCa>gTa	p.A47V		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	47					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				GGCATGATTGCACTGATTCAG	0.488000													96	276					0	0	1	0	0
TPX2	22974	broad.mit.edu	37	20	30345332	30345332	+	Missense_Mutation	SNP	A	A	G			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr20:30345332A>G	ENST00000340513.4	+	3	581	c.53A>G	c.(52-54)aAt>aGt	p.N18S	TPX2_ENST00000300403.6_Missense_Mutation_p.N18S			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	18					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			GATTTCATCAATTTTTCATCC	0.403000													6	120					0	0	1	0	0
KRT16P6	353194	broad.mit.edu	37	17	16722834	16722834	+	RNA	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr17:16722834C>A	ENST00000417510.1	-	0	979																											GCCATCTTCTCGTACTGGTCA	0.552000													35	132					1.36615e-20	1.76161e-20	1	1	0
SLC2A10	81031	broad.mit.edu	37	20	45362400	45362400	+	Missense_Mutation	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr20:45362400C>A	ENST00000359271.2	+	5	1803	c.1553C>A	c.(1552-1554)aCc>aAc	p.T518N		NM_030777.3	NP_110404.1	O95528	GTR10_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 10	518			T -> A (in dbSNP:rs6018008).			endomembrane system|integral to membrane|perinuclear region of cytoplasm|plasma membrane	D-glucose transmembrane transporter activity|sugar:hydrogen symporter activity			central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|liver(2)|lung(13)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	34		Myeloproliferative disorder(115;0.0122)				GACAGGTTCACCCTGAGCTTT	0.617000													15	66					3.41278e-10	4.03928e-10	1	1	0
PRELP	5549	broad.mit.edu	37	1	203453287	203453287	+	Splice_Site	SNP	T	T	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:203453287T>A	ENST00000343110.2	+	2	1100		c.e2+2			NM_002725.3|NM_201348.1	NP_002716.1|NP_958505.1	P51888	PRELP_HUMAN	proline/arginine-rich end leucine-rich repeat protein						skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(15)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36			BRCA - Breast invasive adenocarcinoma(75;0.109)			GCATCGAGAGTGAGTGGGGTG	0.577000													29	46					0	0	1	0	0
RNF150	57484	broad.mit.edu	37	4	142053999	142053999	+	Translation_Start_Site	SNP	C	C	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr4:142053999C>A	ENST00000306799.3	-	0	617				RNF150_ENST00000420921.2_Intron|RNF150_ENST00000507500.1_De_novo_Start_OutOfFrame	NM_020724.1	NP_065775.1	Q9ULK6	RN150_HUMAN	ring finger protein 150							integral to membrane	zinc ion binding			breast(1)|large_intestine(10)|lung(7)|ovary(1)	19	all_hematologic(180;0.162)					cccccgcgccctccctccgtc	0.711000													7	24					8.12818e-05	8.69609e-05	1	1	0
SLC43A3	29015	broad.mit.edu	37	11	57193106	57193106	+	Silent	SNP	G	G	A			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:57193106G>A	ENST00000395123.2	-	4	526	c.222C>T	c.(220-222)ttC>ttT	p.F74F	SLC43A3_ENST00000528098.1_5'UTR|SLC43A3_ENST00000529554.1_Silent_p.F74F|SLC43A3_ENST00000533524.1_Silent_p.F87F|SLC43A3_ENST00000352187.1_Silent_p.F74F|SLC43A3_ENST00000395124.1_Silent_p.F74F	NM_001278201.1|NM_014096.2	NP_001265130.1|NP_054815.2	Q8NBI5	S43A3_HUMAN	solute carrier family 43, member 3	74					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(10)|lung(4)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	27						ACCCCAGGGTGAAGATGAGTG	0.527000													12	48					0	0	1	0	0
SYT2	127833	broad.mit.edu	37	1	202568423	202568425	+	In_Frame_Del	DEL	TCT	TCT	-	rs151217119		TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr1:202568423_202568425delTCT	ENST00000367267.1	-	8	1166_1168	c.974_976delAGA	c.(973-978)aca>a	p.KT325del	SYT2_ENST00000367268.4_In_Frame_Del_p.KT325del	NM_001136504.1	NP_001129976.1	Q8N9I0	SYT2_HUMAN	synaptotagmin II	325	C2 2.|Phospholipid binding (By similarity).				neurotransmitter secretion	cell junction|chromaffin granule membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	protein binding|transporter activity			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(9)|ovary(2)|skin(2)|urinary_tract(1)	29			BRCA - Breast invasive adenocarcinoma(75;0.169)		Botulinum Toxin Type B(DB00042)	TTCACGGTTGTCTTCTTCTTCTT	0.547													30	274	---	---	---	---					
PRSS3P2	154754	broad.mit.edu	37	7	142481743	142481745	+	RNA	DEL	CTA	CTA	-			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr7:142481743_142481745delCTA	ENST00000603901.1	+	0	454					NR_001296.3																						ACCCACATTTCTACTTTCTTTAT	0.517													20	52	---	---	---	---					
PRKDC	5591	broad.mit.edu	37	8	48746799	48746799	+	Frame_Shift_Del	DEL	T	T	-			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr8:48746799delT	ENST00000314191.2	-	60	8163	c.8107delA	c.(8107-8109)ggfs	p.R2703fs	PRKDC_ENST00000338368.3_Frame_Shift_Del_p.R2703fs|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2704	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				AGGCCCAGCCTTTTTTTCCCA	0.498								Non-homologous end-joining					8	585	---	---	---	---					
MUC5B	727897	broad.mit.edu	37	11	1271930	1271930	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:1271930delC	ENST00000447027.1	+	31	13887	c.13829delC	c.(13828-13830)tcfs	p.S4611fs	MUC5B_ENST00000529681.1_Frame_Shift_Del_p.S4608fs			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4608	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ACCCCCTCCTCCAGCCCAGGG	0.652													18	90	---	---	---	---					
BACE1	23621	broad.mit.edu	37	11	117165845	117165863	+	Splice_Site	DEL	ACCCTGGCAATCTCAGCAT	ACCCTGGCAATCTCAGCAT	-			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:117165845_117165863delACCCTGGCAATCTCAGCAT	ENST00000313005.6	-	3	1011_1028	c.567_splice	c.e3+1	p.F184_splice	BACE1_ENST00000528053.1_Splice_Site_p.F184_splice|BACE1_ENST00000514464.1_Intron|BACE1_ENST00000513780.1_Splice_Site_p.F184_splice|BACE1_ENST00000445823.2_Intron|BACE1_ENST00000392937.6_Splice_Site_p.F84_splice|BACE1_ENST00000428381.2_Intron|BACE1_ENST00000510630.1_Splice_Site_p.F84_splice	NM_012104.4|NM_138971.3|NM_138972.3|NM_138973.3	NP_036236.1|NP_620427.1|NP_620428.1|NP_620429.1	P56817	BACE1_HUMAN	beta-site APP-cleaving enzyme 1	184					beta-amyloid metabolic process|membrane protein ectodomain proteolysis	cell surface|cytoplasmic vesicle membrane|endoplasmic reticulum|endosome|integral to plasma membrane|trans-Golgi network	aspartic-type endopeptidase activity|beta-aspartyl-peptidase activity|protein binding	p.R189M(1)		breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000563)|all cancers(92;0.0032)		TGTTCCTCTCACCCTGGCAATCTCAGCATAGGCCAGCCC	0.530													11	34	---	---	---	---					
CBL	867	broad.mit.edu	37	11	119077161	119077161	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr11:119077161delG	ENST00000264033.4	+	1	410	c.34delG	c.(34-36)ggfs	p.G14fs		NM_005188.3	NP_005179.2	P22681	CBL_HUMAN	Cbl proto-oncogene, E3 ubiquitin protein ligase	14					epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(194)|kidney(3)|large_intestine(9)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	251		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		CTCTGGGGCCGGGGGCGGCAG	0.721			"""T, Mis S, O"""	MLL	"""AML, JMML, MDS"""				Noonan syndrome;CBL gene-associated Juvenile Myelomonocytic Leukemia and Developmental Anomalies				2	4	---	---	---	---					
OR4N4	283694	broad.mit.edu	37	15	22382920	22382921	+	Frame_Shift_Ins	INS	-	-	T			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr15:22382920_22382921insT	ENST00000328795.4	+	1	539_540	c.448_449insT	c.(448-450)tggfs	p.W150fs	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GGCTCTGTGGCTTGGGGGTTTT	0.535													35	267	---	---	---	---					
TJP1	7082	broad.mit.edu	37	15	30024870	30024873	+	Frame_Shift_Del	DEL	TTTG	TTTG	-			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr15:30024870_30024873delTTTG	ENST00000346128.6	-	14	2357_2360	c.1883_1886delCAAA	c.(1882-1887)agfs	p.TK628fs	TJP1_ENST00000545208.2_Frame_Shift_Del_p.TK628fs|TJP1_ENST00000356107.6_Frame_Shift_Del_p.TK628fs|TJP1_ENST00000400011.2_Frame_Shift_Del_p.TK632fs	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	628	Guanylate kinase-like.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		AGCTGGAAACTTTGTTTGAACAGG	0.422													48	120	---	---	---	---					
DNM1P47	100216544	broad.mit.edu	37	15	102293062	102293064	+	RNA	DEL	CTC	CTC	-	rs4965539		TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr15:102293062_102293064delCTC	ENST00000561463.1	+	0	1108_1110																											AGTTCATCTTCTCAGAGCTGCTG	0.576													3	5	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74372914	74372914	+	RNA	DEL	G	G	-	rs67181940		TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr16:74372914delG	ENST00000429810.2	-	0	1404																											AACGTAGtttgtttttttttt	0.433													5	7	---	---	---	---					
TVP23C	201158	broad.mit.edu	37	17	15449223	15449223	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr17:15449223delG	ENST00000584811.1	-	5	1561	c.146delC	c.(145-147)ttfs	p.S49fs	TVP23C_ENST00000519970.1_Frame_Shift_Del_p.S27fs|TVP23C_ENST00000225576.3_Frame_Shift_Del_p.S113fs|TVP23C_ENST00000518321.1_Frame_Shift_Del_p.S113fs|TVP23C_ENST00000428082.2_Frame_Shift_Del_p.S113fs|TVP23C_ENST00000438826.3_Frame_Shift_Del_p.S113fs|TVP23C-CDRT4_ENST00000522212.2_Frame_Shift_Del_p.S113fs					trans-golgi network vesicle protein 23 homolog C (S. cerevisiae)																		ATTCTCTTGAGAGGACTCCTA	0.323													35	106	---	---	---	---					
LOC101927060	101927060	broad.mit.edu	37	17	45128629	45128629	+	RNA	DEL	T	T	-			TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr17:45128629delT	ENST00000575173.1	-	0	418																											TTCTGGTGTGtttttttttgt	0.333													9	125	---	---	---	---					
LINC01399	104310353	broad.mit.edu	37	22	35561021	35561021	+	RNA	DEL	C	C	-	rs71191344		TCGA-97-8176-01A-11D-2393-08	TCGA-97-8176-10B-01D-2393-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	470bfb8e-2bdd-4fba-85f5-1889e79642aa	77f8ed6d-bbbc-4962-9dfc-983216d91801	g.chr22:35561021delC	ENST00000423311.1	-	0	512																											ttgctccactcccacttatgg	0.507													7	6	---	---	---	---					
