Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
VGLL3	389136	broad.mit.edu	37	3	87017996	87017996	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr3:87017996C>A	ENST00000398399.2	-	3	1044	c.681G>T	c.(679-681)atG>atT	p.M227I	VGLL3_ENST00000383698.3_Missense_Mutation_p.M227I	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	227	His-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		GGTGGTGCCGCATGTACACGT	0.607000													10	61					0.00185496	0.00191567	1	1	0
GPR63	81491	broad.mit.edu	37	6	97246400	97246400	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr6:97246400C>A	ENST00000229955.3	-	2	1553	c.1208G>T	c.(1207-1209)cGg>cTg	p.R403L	GPR63_ENST00000417980.1_Missense_Mutation_p.R403L	NM_001143957.2|NM_030784.3	NP_001137429.1|NP_110411.1	Q9BZJ6	GPR63_HUMAN	G protein-coupled receptor 63	403						integral to membrane|plasma membrane	G-protein coupled receptor activity|protein binding			kidney(1)|large_intestine(5)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(76;6.89e-05)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.0618)|Colorectal(196;0.0721)		BRCA - Breast invasive adenocarcinoma(108;0.0912)		AGGACGTATCCGTCGCTTTGT	0.468000													6	62					5.9392e-07	6.72005e-07	1	1	0
MBL2	4153	broad.mit.edu	37	10	54529070	54529070	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr10:54529070C>A	ENST00000373968.3	-	3	374	c.310G>T	c.(310-312)Gat>Tat	p.D104Y	MBL2_ENST00000493043.1_5'UTR	NM_000242.2	NP_000233.1	P11226	MBL2_HUMAN	mannose-binding lectin (protein C) 2, soluble	104					acute-phase response|complement activation, classical pathway|complement activation, lectin pathway|defense response to Gram-positive bacterium|negative regulation of growth of symbiont in host|opsonization|response to oxidative stress	collagen|extracellular space	bacterial cell surface binding|calcium-dependent protein binding|eukaryotic cell surface binding|mannose binding|receptor binding			breast(1)|endometrium(2)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21						AGGCTACTATCACCATCTAGA	0.398000													25	61					1.7881e-09	2.26706e-09	1	1	0
LRRC37A11P	342666	broad.mit.edu	37	17	37187737	37187737	+	RNA	SNP	C	C	T	rs12450796	by1000genomes	TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr17:37187737C>T	ENST00000425901.2	+	0	1579					NR_033753.2																						GACTTACCATCACTCCAGAAC	0.498000													8	126					0	0	1	0	0
ZNF3	7551	broad.mit.edu	37	7	99669593	99669593	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr7:99669593C>A	ENST00000303915.6	-	5	1481	c.514G>T	c.(514-516)Gag>Tag	p.E172*	ZNF3_ENST00000299667.4_Nonsense_Mutation_p.E172*|ZNF3_ENST00000413658.2_Intron|ZNF3_ENST00000424697.1_Nonsense_Mutation_p.E172*			P17036	ZNF3_HUMAN	zinc finger protein 3	172					cell differentiation|leukocyte activation|multicellular organismal development	nucleus	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(8)|ovary(1)|skin(2)	25	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)	Ovarian(593;2.06e-05)|Myeloproliferative disorder(862;0.0122)|Breast(660;0.029)	STAD - Stomach adenocarcinoma(171;0.129)			TTATATTTCTCGCTTCTCTCT	0.488000													32	71					8.16721e-17	1.16557e-16	1	1	0
IGKV1-9	28941	broad.mit.edu	37	2	89309946	89309946	+	RNA	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:89309946C>A	ENST00000493819.1	-	0	66																											CGGGGACCCTCATGTCCATGC	0.567000													42	130					6.4771e-29	1.08846e-28	1	1	0
ZNF705B	100132396	broad.mit.edu	37	8	7808219	7808219	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr8:7808219A>T	ENST00000443676.1	+	5	384	c.268A>T	c.(268-270)Ata>Tta	p.I90L	ZNF705B_ENST00000400120.3_Missense_Mutation_p.I90L			P0CI00	Z705L_HUMAN	zinc finger protein 705B	90					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.I90L(4)		kidney(2)|lung(2)	4						AAAACACATGATATCCATGCA	0.328000													7	17					0	0	1	0	0
ALDH1A1	216	broad.mit.edu	37	9	75526923	75526923	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr9:75526923G>T	ENST00000297785.3	-	10	1205	c.1151C>A	c.(1150-1152)cCc>cAc	p.P384H		NM_000689.4	NP_000680.2	P00352	AL1A1_HUMAN	aldehyde dehydrogenase 1 family, member A1	384					cellular aldehyde metabolic process|ethanol oxidation|xenobiotic metabolic process	cytosol	aldehyde dehydrogenase (NAD) activity|androgen binding|Ras GTPase activator activity|retinal dehydrogenase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)	17					NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	GAACACTGTGGGCTGGACAAA	0.443000													11	102					4.68919e-08	5.57209e-08	1	1	0
TENM3	55714	broad.mit.edu	37	4	183594345	183594345	+	Silent	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr4:183594345G>T	ENST00000511685.1	+	7	1422	c.1299G>T	c.(1297-1299)cgG>cgT	p.R433R	TENM3_ENST00000406950.2_Silent_p.R433R					teneurin transmembrane protein 3																		TATATGGCCGGAAAGGCTTAC	0.388000													8	15					0.000274275	0.000289569	1	1	0
SOS1	6654	broad.mit.edu	37	2	39281778	39281778	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:39281778T>A	ENST00000426016.1	-	6	783	c.697A>T	c.(697-699)Aat>Tat	p.N233Y	SOS1_ENST00000395038.2_Missense_Mutation_p.N233Y|SOS1_ENST00000402219.2_Missense_Mutation_p.N233Y|SOS1_ENST00000428721.2_Missense_Mutation_p.N176Y			Q07889	SOS1_HUMAN	son of sevenless homolog 1 (Drosophila)	233	DH.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity	p.N233Y(5)		autonomic_ganglia(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(29)|ovary(4)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	75		all_hematologic(82;0.21)				AATTTTGAATTGGAGACAAAG	0.299000									Noonan syndrome				39	16					0	0	1	0	0
GPR132	29933	broad.mit.edu	37	14	105518155	105518155	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr14:105518155G>T	ENST00000329797.3	-	4	1230	c.319C>A	c.(319-321)Cgc>Agc	p.R107S	GPR132_ENST00000392585.2_Missense_Mutation_p.R98S|GPR132_ENST00000539291.2_Missense_Mutation_p.R107S|GPR132_ENST00000546679.1_5'UTR	NM_013345.2	NP_037477.1	Q9UNW8	GP132_HUMAN	G protein-coupled receptor 132	107					response to stress	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)	18		all_cancers(154;0.0953)|Melanoma(154;0.155)|all_epithelial(191;0.219)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.02)|all cancers(159;0.0419)|OV - Ovarian serous cystadenocarcinoma(161;0.0521)		AGGGTCCAGCGGTGCTGGTTG	0.607000													60	134					1.95512e-22	3.0677e-22	1	1	0
TRAF1	7185	broad.mit.edu	37	9	123675619	123675619	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr9:123675619C>A	ENST00000373887.3	-	5	3137	c.692G>T	c.(691-693)aGc>aTc	p.S231I	TRAF1_ENST00000540010.1_Missense_Mutation_p.S231I|TRAF1_ENST00000546084.1_Missense_Mutation_p.S109I	NM_005658.4	NP_005649.1	Q13077	TRAF1_HUMAN	TNF receptor-associated factor 1	231					apoptosis|positive regulation of NF-kappaB transcription factor activity|protein complex assembly|regulation of apoptosis|signal transduction	cytoplasm	protein binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(4)|pancreas(1)|skin(2)	22						CTGCTCCAAGCTCAGGATGCG	0.607000													13	21					3.27435e-08	3.93062e-08	1	1	0
RPS6KA6	27330	broad.mit.edu	37	X	83351227	83351227	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:83351227C>A	ENST00000262752.2	-	20	1953	c.1946G>T	c.(1945-1947)tGg>tTg	p.W649L	RPS6KA6_ENST00000495332.1_5'UTR|RPS6KA6_ENST00000543399.1_Missense_Mutation_p.W649L	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	649	Protein kinase 2.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						AATATTGTCCCAGTTTCCACC	0.368000													4	47					0.150653	0.151722	1	1	0
RPS6KA6	27330	broad.mit.edu	37	X	83351228	83351228	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:83351228A>G	ENST00000262752.2	-	20	1952	c.1945T>C	c.(1945-1947)Tgg>Cgg	p.W649R	RPS6KA6_ENST00000495332.1_5'UTR|RPS6KA6_ENST00000543399.1_Missense_Mutation_p.W649R	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	649	Protein kinase 2.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						ATATTGTCCCAGTTTCCACCA	0.363000													4	47					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140769198	140769198	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr5:140769198G>T	ENST00000519479.1	+	1	1747	c.1747G>T	c.(1747-1749)Ggc>Tgc	p.G583C	PCDHGA5_ENST00000518069.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA7_ENST00000518325.1_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGCAGAGCCTGGCTACTTGGT	0.652000													25	37					1.39806e-14	1.94631e-14	1	1	0
DKK4	27121	broad.mit.edu	37	8	42232314	42232314	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr8:42232314C>T	ENST00000220812.2	-	3	566	c.380G>A	c.(379-381)aGg>aAg	p.R127K		NM_014420.2	NP_055235.1	Q9UBT3	DKK4_HUMAN	dickkopf WNT signaling pathway inhibitor 4	127					multicellular organismal development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular region				NS(1)|endometrium(1)|large_intestine(7)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	14	all_cancers(6;1.42e-24)|all_epithelial(6;1.02e-25)|all_lung(13;2.58e-12)|Lung NSC(13;4.24e-11)|Ovarian(28;0.00769)|Prostate(17;0.0119)|Colorectal(14;0.1)|Lung SC(25;0.211)	all_lung(54;0.000434)|Lung NSC(58;0.00161)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;3.48e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00523)|Lung(22;0.00597)|LUSC - Lung squamous cell carcinoma(45;0.024)			ACTTGGCTTCCTTTTGGGTTG	0.448000													8	141					0	0	1	0	0
P2RY10	27334	broad.mit.edu	37	X	78216209	78216209	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:78216209C>A	ENST00000171757.2	+	4	472	c.192C>A	c.(190-192)agC>agA	p.S64R	P2RY10_ENST00000544091.1_Missense_Mutation_p.S64R|P2RY10_ENST00000475374.1_3'UTR	NM_014499.2	NP_055314.1	O00398	P2Y10_HUMAN	purinergic receptor P2Y, G-protein coupled, 10	64						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(22)|ovary(3)|skin(2)	42						GCTTCATCAGCAAGAAAAATA	0.433000													40	91					3.38236e-24	5.52063e-24	1	1	0
CBFA2T3	863	broad.mit.edu	37	16	88945685	88945685	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr16:88945685G>T	ENST00000268679.4	-	11	2051	c.1655C>A	c.(1654-1656)tCc>tAc	p.S552Y	CBFA2T3_ENST00000448839.1_Missense_Mutation_p.S476Y|CBFA2T3_ENST00000436887.2_Missense_Mutation_p.S514Y|CBFA2T3_ENST00000360302.2_Missense_Mutation_p.S466Y|CBFA2T3_ENST00000327483.5_Missense_Mutation_p.S466Y	NM_005187.5	NP_005178.4	O75081	MTG16_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	552					cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0275)		TACCTCGCTGGAGTCCTCCTG	0.697000			T	RUNX1	AML								18	22					1.33834e-09	1.71211e-09	1	1	0
TSC22D2	9819	broad.mit.edu	37	3	150127639	150127639	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr3:150127639G>T	ENST00000361875.2	+	1	1518	c.502G>T	c.(502-504)Gac>Tac	p.D168Y	TSC22D2_ENST00000361136.2_Missense_Mutation_p.D168Y	NM_014779.2	NP_055594.1	O75157	T22D2_HUMAN	TSC22 domain family, member 2	168							sequence-specific DNA binding transcription factor activity			cervix(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	18			LUSC - Lung squamous cell carcinoma(72;0.0538)|Lung(72;0.066)			GATCAAGCTGGACCACGGGAG	0.622000													47	59					6.27289e-28	1.04181e-27	1	1	0
FER1L5	90342	broad.mit.edu	37	2	97361315	97361315	+	RNA	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:97361315G>A	ENST00000457909.1	+	0	3314							A0AVI2	FR1L5_HUMAN	fer-1-like 5 (C. elegans)							integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(9)|large_intestine(9)|lung(6)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	38						ATTCGGGGAAGAGTCCCTGAG	0.587000													4	13					0	0	1	0	0
SPTAN1	6709	broad.mit.edu	37	9	131337584	131337584	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr9:131337584G>T	ENST00000358161.5	+	5	724	c.611G>T	c.(610-612)aGa>aTa	p.R204I	SPTAN1_ENST00000372731.4_Missense_Mutation_p.R204I|SPTAN1_ENST00000372739.3_Missense_Mutation_p.R204I			Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	204					actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			NS(2)|breast(8)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(21)|liver(1)|lung(25)|ovary(5)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	87						CATGAAGAAAGAGTTAATGAA	0.363000													21	48					4.35082e-09	5.4674e-09	1	1	0
HUWE1	10075	broad.mit.edu	37	X	53574893	53574893	+	Silent	SNP	G	G	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:53574893G>C	ENST00000342160.3	-	67	10834	c.10377C>G	c.(10375-10377)ctC>ctG	p.L3459L	HUWE1_ENST00000474288.1_5'UTR|HUWE1_ENST00000262854.6_Silent_p.L3459L			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	3459					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						CAATTGAGATGAGAGAAAGGA	0.532000													13	30					0	0	1	0	0
STK39	27347	broad.mit.edu	37	2	168873606	168873606	+	Splice_Site	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:168873606C>T	ENST00000355999.4	-	15	2082		c.e15-1		STK39_ENST00000487143.1_Splice_Site	NM_013233.2	NP_037365.2	Q9UEW8	STK39_HUMAN	serine threonine kinase 39						response to stress	cytoplasm|nucleus	ATP binding|protein binding|receptor signaling protein serine/threonine kinase activity			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|skin(2)	13						TCTGGAGTTTCTGAAATACAT	0.323000													17	47					0	0	1	0	0
VGLL3	389136	broad.mit.edu	37	3	87017995	87017995	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr3:87017995G>C	ENST00000398399.2	-	3	1045	c.682C>G	c.(682-684)Cgg>Ggg	p.R228G	VGLL3_ENST00000383698.3_Missense_Mutation_p.R228G	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	228	His-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.R228W(1)		NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		TGGTGGTGCCGCATGTACACG	0.612000													10	60					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129902432	129902432	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr10:129902432C>A	ENST00000368654.3	-	13	8047	c.7672G>T	c.(7672-7674)Gac>Tac	p.D2558Y	MKI67_ENST00000368653.3_Missense_Mutation_p.D2198Y	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2558	16 X 122 AA approximate repeats.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCAACCAGGTCTTCTAGAGCA	0.488000													52	93					1.67211e-32	2.86072e-32	1	1	0
OXCT1	5019	broad.mit.edu	37	5	41794128	41794128	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr5:41794128C>A	ENST00000196371.5	-	13	1385	c.1225G>T	c.(1225-1227)Gac>Tac	p.D409Y	OXCT1_ENST00000510634.1_Missense_Mutation_p.D12Y|OXCT1_ENST00000513081.1_5'UTR|OXCT1_ENST00000509987.1_Missense_Mutation_p.D223Y|OXCT1_ENST00000512084.1_Missense_Mutation_p.D12Y	NM_000436.3	NP_000427.1	P55809	SCOT1_HUMAN	3-oxoacid CoA transferase 1	409					cellular lipid metabolic process|ketone body catabolic process	mitochondrial matrix	3-oxoacid CoA-transferase activity|protein homodimerization activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(2)	28					Succinic acid(DB00139)	TTAGCCAGGTCACCATATTTG	0.368000													33	110					1.836e-18	2.70168e-18	1	1	0
MIR325	442899	broad.mit.edu	37	X	76225864	76225864	+	RNA	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:76225864C>A	ENST00000385260.1	-	0	62					NR_029905.1																						gataggaggtcctcaataaac	0.403000													23	69					1.10513e-12	1.48046e-12	1	1	0
SPAG17	200162	broad.mit.edu	37	1	118527376	118527376	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:118527376A>T	ENST00000336338.5	-	41	5764	c.5699T>A	c.(5698-5700)cTa>cAa	p.L1900Q		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1900						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		AATATCCATTAGGTAATTCTG	0.303000													27	50					0	0	1	0	0
GTF3C1	2975	broad.mit.edu	37	16	27500985	27500985	+	Silent	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr16:27500985C>T	ENST00000356183.4	-	20	3246	c.3231G>A	c.(3229-3231)gaG>gaA	p.E1077E	GTF3C1_ENST00000561623.1_Silent_p.E1077E	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1077						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						CGCTCTCCTGCTCCTTCTGCA	0.657000													6	7					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84609550	84609550	+	Missense_Mutation	SNP	G	G	T	rs113456427		TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr9:84609550G>T	ENST00000344803.2	+	4	4212	c.4165G>T	c.(4165-4167)Ggt>Tgt	p.G1389C		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		GCAGAATATTGGTCGAGTTAT	0.443000													7	21					2.0095e-06	2.22929e-06	1	1	0
RAPH1	65059	broad.mit.edu	37	2	204305090	204305090	+	Silent	SNP	T	T	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:204305090T>C	ENST00000319170.5	-	14	3122	c.2823A>G	c.(2821-2823)ccA>ccG	p.P941P	RAPH1_ENST00000374493.3_Silent_p.P993P|RAPH1_ENST00000457812.1_Intron	NM_213589.1	NP_998754.1	Q70E73	RAPH1_HUMAN	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	941					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				breast(5)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						tgggtggaggtggtggtggtg	0.607000													48	48					0	0	1	0	0
DMXL1	1657	broad.mit.edu	37	5	118485508	118485508	+	Missense_Mutation	SNP	A	A	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr5:118485508A>C	ENST00000311085.8	+	18	4066	c.3986A>C	c.(3985-3987)cAg>cCg	p.Q1329P	DMXL1_ENST00000539542.1_Missense_Mutation_p.Q1329P	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1329										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		CATCCCTTGCAGCTTTTGGAA	0.453000													24	49					0	0	1	0	0
ERN1	2081	broad.mit.edu	37	17	62131718	62131718	+	Silent	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr17:62131718C>A	ENST00000433197.2	-	15	1940	c.1845G>T	c.(1843-1845)ctG>ctT	p.L615L		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	615	Protein kinase.				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						ATTCTCGCAACAGCTGGACCT	0.592000													11	12					4.68919e-08	5.57209e-08	1	1	0
ZACN	353174	broad.mit.edu	37	17	74076406	74076406	+	Missense_Mutation	SNP	C	C	G	rs141226835		TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr17:74076406C>G	ENST00000334586.5	+	5	528	c.445C>G	c.(445-447)Ctg>Gtg	p.L149V	ZACN_ENST00000392503.2_Intron	NM_180990.3	NP_851321.2	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	149					response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	11						GAAGCTCAACCTGGCCCTCGC	0.642000													23	61					0	0	1	0	0
FBLN1	2192	broad.mit.edu	37	22	45918978	45918978	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr22:45918978G>T	ENST00000402984.3	+	3	296	c.193G>T	c.(193-195)Ggg>Tgg	p.G65W	FBLN1_ENST00000327858.6_Intron|FBLN1_ENST00000262722.7_Intron|FBLN1_ENST00000442170.2_Intron|FBLN1_ENST00000348697.2_Intron|FBLN1_ENST00000340923.5_Intron			P23142	FBLN1_HUMAN	fibulin 1	62	Anaphylatoxin-like 1.				interspecies interaction between organisms	extracellular space|soluble fraction	calcium ion binding|extracellular matrix structural constituent|protein binding			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(1)	30		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		tagagccgtggggttggcctc	0.582000													4	8					0.00024832	0.000263145	1	1	0
FGD2	221472	broad.mit.edu	37	6	36990024	36990024	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr6:36990024G>A	ENST00000274963.8	+	13	1507	c.1336G>A	c.(1336-1338)Gag>Aag	p.E446K		NM_173558.3	NP_775829.2	Q7Z6J4	FGD2_HUMAN	FYVE, RhoGEF and PH domain containing 2	446					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|early endosome membrane|Golgi apparatus|lamellipodium|nucleus|ruffle membrane	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	25						GCTGCAGTCTGAGGAGCTGGG	0.667000											OREG0017395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	19					0	0	1	0	0
LALBA	3906	broad.mit.edu	37	12	48963777	48963777	+	Silent	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr12:48963777C>T	ENST00000549817.1	-	1	72	c.27G>A	c.(25-27)ctG>ctA	p.L9L	LALBA_ENST00000301046.2_Silent_p.L9L			P00709	LALBA_HUMAN	lactalbumin, alpha-	9					cell-cell signaling|defense response to bacterium|induction of apoptosis|lactose biosynthetic process|signal transduction	extracellular space	calcium ion binding|lactose synthase activity			large_intestine(1)|stomach(2)	3						GGATGCCCACCAGGAACAGAG	0.468000													23	54					0	0	1	0	0
ZMYND11	10771	broad.mit.edu	37	10	294440	294440	+	Silent	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr10:294440G>A	ENST00000397962.3	+	13	1820	c.1392G>A	c.(1390-1392)caG>caA	p.Q464Q	ZMYND11_ENST00000558098.2_Silent_p.Q464Q|ZMYND11_ENST00000545619.1_Silent_p.Q344Q|ZMYND11_ENST00000381584.1_Silent_p.Q447Q|ZMYND11_ENST00000397959.3_Silent_p.Q379Q|ZMYND11_ENST00000602682.1_Silent_p.Q379Q|ZMYND11_ENST00000535374.1_Silent_p.Q259Q|ZMYND11_ENST00000509513.2_Silent_p.Q463Q|ZMYND11_ENST00000381607.4_Silent_p.Q370Q|ZMYND11_ENST00000309776.4_Silent_p.Q424Q|ZMYND11_ENST00000381602.4_Silent_p.Q424Q|ZMYND11_ENST00000381591.1_Silent_p.Q464Q|ZMYND11_ENST00000403354.1_Silent_p.Q384Q|ZMYND11_ENST00000473115.1_3'UTR|ZMYND11_ENST00000381604.4_Silent_p.Q424Q|ZMYND11_ENST00000402736.1_Silent_p.Q433Q			Q15326	ZMY11_HUMAN	zinc finger, MYND-type containing 11	424	Interaction with human adenovirus E1A.				cell cycle|cell proliferation|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|skin(2)	24		all_cancers(4;1.32e-05)|all_lung(4;3.67e-05)|Lung NSC(4;0.000301)|all_epithelial(10;0.000416)|Colorectal(49;0.14)	OV - Ovarian serous cystadenocarcinoma(33;0.132)	Epithelial(11;0.00289)|all cancers(11;0.0108)|Lung(33;0.0689)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		GCGTGTGTCAGAGCATGTGCC	0.502000													13	90					0	0	1	0	0
CYP3A7	1551	broad.mit.edu	37	7	99328720	99328720	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr7:99328720G>A	ENST00000336374.2	-	2	129	c.127C>T	c.(127-129)Cct>Tct	p.P43S		NM_000765.3	NP_000756.2	P24462	CP3A7_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 7	43					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			autonomic_ganglia(1)|breast(3)|endometrium(2)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	32	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)					AAAGGCAGAGGTGTGGGCCCT	0.413000													23	53					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55925731	55925731	+	Silent	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr6:55925731C>A	ENST00000244728.5	-	26	2707	c.2310G>T	c.(2308-2310)ggG>ggT	p.G770G	COL21A1_ENST00000370819.1_Silent_p.G767G|COL21A1_ENST00000370808.2_Silent_p.G170G|COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000535941.1_Silent_p.G770G	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	770	Collagen-like 5.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			GACCTGGATCCCCAGGTTGCC	0.512000													15	37					1.3612e-06	1.52198e-06	1	1	0
RIMBP2	23504	broad.mit.edu	37	12	130923022	130923022	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr12:130923022C>A	ENST00000261655.4	-	9	1656	c.1493G>T	c.(1492-1494)gGg>gTg	p.G498V	RIMBP2_ENST00000536002.1_Missense_Mutation_p.G406V|RIMBP2_ENST00000535703.1_Missense_Mutation_p.G406V	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	498	Fibronectin type-III 3.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		GGGGGTCACCCCAGCCTGGAC	0.667000													13	12					0.00010058	0.000107386	1	1	0
KRT1	3848	broad.mit.edu	37	12	53069263	53069263	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr12:53069263C>A	ENST00000252244.3	-	9	1707	c.1649G>T	c.(1648-1650)gGc>gTc	p.G550V		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	550	Gly/Ser-rich.|Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						gccatagctgccacggccgcc	0.697000													3	11					6.4e-05	6.88485e-05	1	1	0
FOXB2	442425	broad.mit.edu	37	9	79635564	79635564	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr9:79635564G>A	ENST00000376708.1	+	1	994	c.994G>A	c.(994-996)Gca>Aca	p.A332T		NM_001013735.1	NP_001013757.1	Q5VYV0	FOXB2_HUMAN	forkhead box B2	332	Poly-Ala.				brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			breast(1)|lung(8)|ovary(1)	10						cgccgcagccgcagccgGAGT	0.726000													4	10					0	0	1	0	0
TADA3	10474	broad.mit.edu	37	3	9828886	9828886	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr3:9828886T>C	ENST00000343450.2	-	5	1250	c.703A>G	c.(703-705)Aaa>Gaa	p.K235E	TADA3_ENST00000440161.1_Missense_Mutation_p.K235E|TADA3_ENST00000301964.2_Missense_Mutation_p.K235E	NM_133480.1	NP_597814.1	O75528	TADA3_HUMAN	transcriptional adaptor 3	235					estrogen receptor signaling pathway|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	ligand-dependent nuclear receptor binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	16						GGCCTACCTTTAGTGTCCAGT	0.602000											OREG0015382	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	52	93					0	0	1	0	0
ST14	6768	broad.mit.edu	37	11	130078384	130078384	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr11:130078384C>T	ENST00000278742.5	+	17	2492	c.2074C>T	c.(2074-2076)Cgc>Tgc	p.R692C		NM_021978.3	NP_068813.1	Q9Y5Y6	ST14_HUMAN	suppression of tumorigenicity 14 (colon carcinoma)	692	Peptidase S1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|pancreas(2)|prostate(1)|skin(3)	32	all_hematologic(175;0.0429)	Lung NSC(97;0.000602)|Breast(109;0.000962)|all_lung(97;0.00126)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0183)|Lung(977;0.228)	Urokinase(DB00013)	GGTGCAGGAGCGCAGGCTCAA	0.622000													25	20					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15600177	15600177	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr10:15600177G>T	ENST00000378076.3	-	26	3015	c.2662C>A	c.(2662-2664)Cct>Act	p.P888T		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	888					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity	p.P888S(1)		NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CTGAGCTCAGGGGTGTCCTCT	0.458000													14	54					0.00316338	0.00324332	1	1	0
SSH1	54434	broad.mit.edu	37	12	109201542	109201542	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr12:109201542C>G	ENST00000326495.5	-	8	691	c.598G>C	c.(598-600)Ggg>Cgg	p.G200R	SSH1_ENST00000360239.3_5'UTR|SSH1_ENST00000326470.5_Missense_Mutation_p.G211R|SSH1_ENST00000551165.1_Missense_Mutation_p.G200R	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	200					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GCTACACCCCCGGGGAAGTAG	0.612000													29	37					0	0	1	0	0
CCDC180	100499483	broad.mit.edu	37	9	100056350	100056350	+	Missense_Mutation	SNP	G	G	A	rs147780854		TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr9:100056350G>A	ENST00000357054.1	+	13	1143	c.208G>A	c.(208-210)Gac>Aac	p.D70N	CCDC180_ENST00000395220.1_Missense_Mutation_p.D70N|RP11-23J9.4_ENST00000534123.1_RNA|CCDC180_ENST00000375205.2_Missense_Mutation_p.D110N|RP11-23J9.5_ENST00000375204.2_RNA|CCDC180_ENST00000375202.2_5'UTR|CCDC180_ENST00000411667.2_5'UTR					coiled-coil domain containing 180																		TGCCCGCATCGACAGGACCAT	0.582000													13	89					0	0	1	0	0
ADAM17	6868	broad.mit.edu	37	2	9630449	9630449	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:9630449C>G	ENST00000310823.3	-	19	2514	c.2332G>C	c.(2332-2334)Gag>Cag	p.E778Q	IAH1_ENST00000545602.1_Intron	NM_003183.4	NP_003174.3	P78536	ADA17_HUMAN	ADAM metallopeptidase domain 17	778					B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			breast(1)|cervix(4)|endometrium(2)|kidney(2)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	28	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		GGGTCCTTCTCAAACCCATCC	0.537000													29	17					0	0	1	0	0
GLG1	2734	broad.mit.edu	37	16	74506311	74506311	+	Splice_Site	SNP	T	T	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr16:74506311T>C	ENST00000422840.2	-	14	2052		c.e14-2		GLG1_ENST00000205061.5_Splice_Site|GLG1_ENST00000447066.2_Splice_Site	NM_001145667.1	NP_001139139.1	Q92896	GSLG1_HUMAN	golgi glycoprotein 1							Golgi membrane|integral to membrane	receptor binding			breast(2)|cervix(2)|endometrium(6)|kidney(8)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(1)	57						TTGAATATCCTGTAGAAAATT	0.398000													12	33					0	0	1	0	0
MTA2	9219	broad.mit.edu	37	11	62364116	62364116	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr11:62364116T>A	ENST00000278823.2	-	9	1264	c.875A>T	c.(874-876)cAg>cTg	p.Q292L	MTA2_ENST00000527204.1_Missense_Mutation_p.Q119L|MTA2_ENST00000524902.1_Missense_Mutation_p.Q119L	NM_004739.3	NP_004730.2	O94776	MTA2_HUMAN	metastasis associated 1 family, member 2	292	SANT.				chromatin assembly or disassembly	NuRD complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	26						TACAAAATCCTGGCGAATATC	0.532000													28	62					0	0	1	0	0
OR11L1	391189	broad.mit.edu	37	1	248004941	248004941	+	Silent	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:248004941C>G	ENST00000355784.2	-	1	313	c.258G>C	c.(256-258)ctG>ctC	p.L86L		NM_001001959.1	NP_001001959.1	Q8NGX0	O11L1_HUMAN	olfactory receptor, family 11, subfamily L, member 1	86					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(5)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57	all_cancers(71;8.78e-05)|all_epithelial(71;9.15e-06)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GGCCCCAGGACAGCAGGTTGG	0.577000													8	46					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10364089	10364089	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:10364089G>T	ENST00000377093.4	+	21	2999	c.2846G>T	c.(2845-2847)aGg>aTg	p.R949M	KIF1B_ENST00000377081.1_Intron|KIF1B_ENST00000263934.6_Intron|KIF1B_ENST00000377086.1_Intron|KIF1B_ENST00000377083.1_Missense_Mutation_p.R949M	NM_183416.3	NP_904325.2	O60333	KIF1B_HUMAN	kinesin family member 1B	0					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		GTACCTCATAGGTTCATCCCT	0.493000													45	65					7.05121e-23	1.11874e-22	1	1	0
PCDHA11	56138	broad.mit.edu	37	5	140249145	140249145	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr5:140249145C>G	ENST00000398640.2	+	1	457	c.457C>G	c.(457-459)Cca>Gca	p.P153A	PCDHA10_ENST00000307360.5_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCGCGTTTTCCACTAGAGGG	0.448000													76	136					0	0	1	0	0
TMTC1	83857	broad.mit.edu	37	12	29736491	29736491	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr12:29736491G>T	ENST00000256062.5	-	8	1416	c.943C>A	c.(943-945)Ctt>Att	p.L315I	TMTC1_ENST00000539277.1_Missense_Mutation_p.L423I|TMTC1_ENST00000381224.2_Missense_Mutation_p.L377I|TMTC1_ENST00000551659.1_Missense_Mutation_p.L485I|TMTC1_ENST00000552618.1_Missense_Mutation_p.L485I|TMTC1_ENST00000319685.8_5'UTR	NM_175861.3	NP_787057.2	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat containing 1	423						integral to membrane	binding			breast(1)|endometrium(4)|kidney(3)|large_intestine(17)|lung(45)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					TGCACAAAAAGGATGCAGTAG	0.498000													14	32					1.5842e-08	1.93928e-08	1	1	0
OR4A15	81328	broad.mit.edu	37	11	55136058	55136058	+	Silent	SNP	G	G	C	rs141225150	byFrequency	TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr11:55136058G>C	ENST00000314706.3	+	1	699	c.699G>C	c.(697-699)gcG>gcC	p.A233A		NM_001005275.1	NP_001005275.1	Q8NGL6	O4A15_HUMAN	olfactory receptor, family 4, subfamily A, member 15	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A233A(1)		NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(48)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	71						ATGGAGGAGCGATTTGTGCTG	0.413000													45	85					0	0	1	0	0
MAGIX	79917	broad.mit.edu	37	X	49021366	49021366	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:49021366A>T	ENST00000376338.3	+	2	347	c.268A>T	c.(268-270)Act>Tct	p.T90S	MAGIX_ENST00000376339.1_Missense_Mutation_p.T90S|MAGIX_ENST00000412696.2_Missense_Mutation_p.T149S|MAGIX_ENST00000425661.2_Intron|MAGIX_ENST00000498742.1_3'UTR			Q9H6Y5	MAGIX_HUMAN	MAGI family member, X-linked	149																	AGCTGGGGACACTCCGCTGGC	0.637000													35	69					0	0	1	0	0
KERA	11081	broad.mit.edu	37	12	91450009	91450009	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr12:91450009G>T	ENST00000266719.3	-	2	297	c.50C>A	c.(49-51)aCt>aAt	p.T17N		NM_007035.3	NP_008966.1	O60938	KERA_HUMAN	keratocan	17					response to stimulus|visual perception	proteinaceous extracellular matrix				breast(2)|large_intestine(8)|lung(5)|prostate(2)|skin(2)	19						AGACCACACAGTGTCTGTTAT	0.418000													22	57					1.85244e-09	2.33819e-09	1	1	0
COL21A1	81578	broad.mit.edu	37	6	55925732	55925732	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr6:55925732C>A	ENST00000244728.5	-	26	2706	c.2309G>T	c.(2308-2310)gGg>gTg	p.G770V	COL21A1_ENST00000370819.1_Missense_Mutation_p.G767V|COL21A1_ENST00000370808.2_Missense_Mutation_p.G170V|COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000535941.1_Missense_Mutation_p.G770V	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	770	Collagen-like 5.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			ACCTGGATCCCCAGGTTGCCC	0.517000													15	38					1.3612e-06	1.52198e-06	1	1	0
KRT28	162605	broad.mit.edu	37	17	38954528	38954528	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr17:38954528G>T	ENST00000306658.7	-	3	714	c.649C>A	c.(649-651)Ctg>Atg	p.L217M		NM_181535.3	NP_853513.2	Q7Z3Y7	K1C28_HUMAN	keratin 28	217	Coil 1B.|Rod.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30		Breast(137;0.000301)				TCCTCACTCAGAGACTCATAT	0.493000													9	62					0.000442599	0.000462126	1	1	0
RPGRIP1L	23322	broad.mit.edu	37	16	53686795	53686795	+	Silent	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr16:53686795G>T	ENST00000262135.4	-	15	1897	c.1804C>A	c.(1804-1806)Cga>Aga	p.R602R	RPGRIP1L_ENST00000379925.3_Silent_p.R602R|RPGRIP1L_ENST00000564374.1_Silent_p.R602R|RPGRIP1L_ENST00000563746.1_Silent_p.R602R	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	602					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				TTTTCGCCTCGTTCTAAGTGG	0.368000													35	43					4.31634e-10	5.59744e-10	1	1	0
LAMA2	3908	broad.mit.edu	37	6	129823818	129823818	+	Silent	SNP	A	A	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr6:129823818A>T	ENST00000421865.2	+	59	8308	c.8259A>T	c.(8257-8259)gcA>gcT	p.A2753A		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2753					cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTTGTGCTGCAGAATCAGAAC	0.393000													9	27					0	0	1	0	0
HCRTR1	3061	broad.mit.edu	37	1	32089241	32089241	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:32089241G>A	ENST00000403528.2	+	7	1241	c.856G>A	c.(856-858)Gaa>Aaa	p.E286K	HCRTR1_ENST00000373705.1_Missense_Mutation_p.E286K|HCRTR1_ENST00000373706.5_Missense_Mutation_p.E286K|HCRTR1_ENST00000468521.1_3'UTR	NM_001525.2	NP_001516.2	O43613	OX1R_HUMAN	hypocretin (orexin) receptor 1	286					feeding behavior|neuropeptide signaling pathway|synaptic transmission	integral to plasma membrane				breast(2)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	7		Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.053)		CTTCCTGGCTGAAGTGAAGCA	0.647000													14	34					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74019391	74019391	+	Silent	SNP	G	G	A	rs139816112	byFrequency	TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr17:74019391G>A	ENST00000301607.3	-	4	715	c.462C>T	c.(460-462)cgC>cgT	p.R154R	EVPL_ENST00000586740.1_Silent_p.R154R	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	154	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GCTCCAGCACGCGTGCCCAGT	0.612000													6	96					0	0	1	0	0
OFD1	8481	broad.mit.edu	37	X	13771519	13771519	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:13771519T>C	ENST00000380567.1	+	12	1540	c.668T>C	c.(667-669)aTt>aCt	p.I223T	OFD1_ENST00000380550.3_Missense_Mutation_p.I323T|OFD1_ENST00000490265.1_3'UTR|OFD1_ENST00000340096.6_Missense_Mutation_p.I363T			O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	363					cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	25						GACTACATCATTAGAACTAAT	0.378000													33	74					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51798979	51798979	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr6:51798979G>A	ENST00000371117.3	-	37	6325	c.6050C>T	c.(6049-6051)tCc>tTc	p.S2017F	PKHD1_ENST00000340994.4_Missense_Mutation_p.S2017F	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	2017	G8 1.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					AGTTGAGTAGGAACTCCCGTA	0.517000											OREG0017491	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	63					0	0	1	0	0
DENND2A	27147	broad.mit.edu	37	7	140221682	140221682	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr7:140221682G>A	ENST00000275884.6	-	17	3301	c.2884C>T	c.(2884-2886)Cgg>Tgg	p.R962W	DENND2A_ENST00000537639.1_Missense_Mutation_p.R962W|DENND2A_ENST00000496613.1_Missense_Mutation_p.R962W			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	962	dDENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					CGCAGCTCCCGCTCCTGGATG	0.607000													31	51					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65392665	65392665	+	Silent	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr11:65392665C>A	ENST00000355703.3	+	17	3482	c.2943C>A	c.(2941-2943)gtC>gtA	p.V981V		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	981						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						AGCAGCACGTCCCTGTCCTCT	0.652000													5	16					0.00116845	0.00121109	1	1	0
FILIP1	27145	broad.mit.edu	37	6	76022793	76022793	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr6:76022793C>A	ENST00000393004.2	-	5	2976	c.2755G>T	c.(2755-2757)Gag>Tag	p.E919*	FILIP1_ENST00000370020.1_Nonsense_Mutation_p.E820*|FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Nonsense_Mutation_p.E919*			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	919								p.E919*(1)		breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						GTGCTGTTCTCGTGGTCTGGT	0.498000													64	111					7.82978e-24	1.27066e-23	1	1	0
OR7E91P	79315	broad.mit.edu	37	2	71256954	71256954	+	RNA	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:71256954C>T	ENST00000434990.1	-	0	61																											ACATTCAAAGCGCCCTGTGGA	0.507000													3	7					0	0	1	0	0
CCDC132	55610	broad.mit.edu	37	7	92921060	92921060	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr7:92921060A>G	ENST00000544910.1	+	14	1118	c.898A>G	c.(898-900)Aaa>Gaa	p.K300E	CCDC132_ENST00000535481.1_Missense_Mutation_p.K50E|CCDC132_ENST00000305866.5_Missense_Mutation_p.K330E|CCDC132_ENST00000317751.6_Missense_Mutation_p.K61E|CCDC132_ENST00000541136.1_Missense_Mutation_p.K141E	NM_001257998.1	NP_001244927.1	Q96JG6	CC132_HUMAN	coiled-coil domain containing 132	330										endometrium(1)|large_intestine(2)|lung(5)	8	all_cancers(62;2.64e-11)|all_epithelial(64;1.4e-10)|Breast(17;0.000675)|Lung NSC(181;0.0618)|all_lung(186;0.0837)		STAD - Stomach adenocarcinoma(171;0.000302)			AGACCTGTGCAAAGCACTATG	0.368000													18	38					0	0	1	0	0
DCUN1D4	23142	broad.mit.edu	37	4	52729838	52729838	+	Silent	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr4:52729838C>T	ENST00000334635.5	+	3	279	c.99C>T	c.(97-99)aaC>aaT	p.N33N	DCUN1D4_ENST00000513800.1_3'UTR|DCUN1D4_ENST00000381441.3_Silent_p.N33N|DCUN1D4_ENST00000451288.2_Silent_p.N77N|DCUN1D4_ENST00000381437.4_5'UTR	NM_001040402.1	NP_001035492.1	Q92564	DCNL4_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 4	33										endometrium(2)|large_intestine(2)|lung(2)|ovary(2)|skin(1)	9			GBM - Glioblastoma multiforme(4;1.93e-11)|LUSC - Lung squamous cell carcinoma(32;0.00654)			TCTTTCAGAACCTAACAGAAG	0.294000													26	50					0	0	1	0	0
ARHGAP32	9743	broad.mit.edu	37	11	128839563	128839563	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr11:128839563C>T	ENST00000310343.9	-	22	5502	c.5503G>A	c.(5503-5505)Gag>Aag	p.E1835K	ARHGAP32_ENST00000527272.1_Missense_Mutation_p.E1486K|ARHGAP32_ENST00000392657.3_Missense_Mutation_p.E1486K|ARHGAP32_ENST00000524655.1_3'UTR	NM_001142685.1	NP_001136157.1	A7KAX9	RHG32_HUMAN	Rho GTPase activating protein 32	1835	Interaction with FYN.				cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(28)|ovary(3)|prostate(6)|urinary_tract(3)	60						CTGTCCATCTCTGCCTCGGGA	0.612000													29	77					0	0	1	0	0
SLC38A5	92745	broad.mit.edu	37	X	48326126	48326126	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:48326126G>T	ENST00000376876.3	-	3	943	c.100C>A	c.(100-102)Cct>Act	p.P34T	SLC38A5_ENST00000317669.5_Missense_Mutation_p.P34T			Q8WUX1	S38A5_HUMAN	solute carrier family 38, member 5	34					cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane				breast(1)|cervix(1)|endometrium(6)|large_intestine(2)|lung(5)|ovary(3)|skin(1)	19						TTGCTCCCAGGAGCAGGACCA	0.592000											OREG0019763	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	20					0.0293803	0.0299069	1	1	0
OR8H3	390152	broad.mit.edu	37	11	55890340	55890340	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr11:55890340C>A	ENST00000313472.3	+	1	492	c.492C>A	c.(490-492)agC>agA	p.S164R		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	164					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					TTTCCATGAGCAGATTGCATT	0.433000													77	240					8.21609e-47	1.42279e-46	1	1	0
GLI2	2736	broad.mit.edu	37	2	121747580	121747580	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:121747580G>T	ENST00000452319.1	+	14	4150	c.4090G>T	c.(4090-4092)Gca>Tca	p.A1364S	GLI2_ENST00000314490.11_Intron|GLI2_ENST00000361492.4_Missense_Mutation_p.A1364S			P10070	GLI2_HUMAN	GLI family zinc finger 2	1364					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GGTGGCTACAGCAGGCTTTGG	0.697000													22	19					7.45023e-12	9.93363e-12	1	1	0
ITGA11	22801	broad.mit.edu	37	15	68653962	68653962	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr15:68653962G>C	ENST00000423218.2	-	5	533	c.438C>G	c.(436-438)ttC>ttG	p.F146L	ITGA11_ENST00000562826.1_5'UTR|ITGA11_ENST00000315757.7_Missense_Mutation_p.F146L			Q9UKX5	ITA11_HUMAN	integrin, alpha 11	146					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development	integrin complex	collagen binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(6)|lung(22)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	52					Tirofiban(DB00775)	TGGAGAACCTGAAGTTGGAGT	0.562000													4	8					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28993193	28993193	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr18:28993193C>A	ENST00000359747.4	+	15	2844	c.2815C>A	c.(2815-2817)Ccc>Acc	p.P939T	RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Missense_Mutation_p.P920T|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	920					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ATGTGTGCAACCCACTACAAT	0.423000													64	156					7.92265e-33	1.36366e-32	1	1	0
LRRC7	57554	broad.mit.edu	37	1	70397230	70397230	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:70397230G>A	ENST00000310961.5	+	9	1007	c.589G>A	c.(589-591)Ggc>Agc	p.G197S	LRRC7_ENST00000035383.5_Missense_Mutation_p.G192S|LRRC7_ENST00000415775.2_5'UTR			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	192						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						ACTTGACCTAGGCAATAATGA	0.388000													5	23					0	0	1	0	0
CEP55	55165	broad.mit.edu	37	10	95263058	95263058	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr10:95263058G>T	ENST00000371485.3	+	3	676	c.372G>T	c.(370-372)gaG>gaT	p.E124D		NM_001127182.1|NM_018131.4	NP_001120654.1|NP_060601.3	Q53EZ4	CEP55_HUMAN	centrosomal protein 55kDa	124					cell division|mitosis	centriole|cleavage furrow|midbody				kidney(1)|large_intestine(5)|lung(6)|stomach(1)	13		Colorectal(252;0.207)				TATCTGAAGAGAAAGACGTAT	0.428000													31	66					7.01153e-11	9.13429e-11	1	1	0
TDP1	55775	broad.mit.edu	37	14	90450920	90450920	+	Silent	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr14:90450920G>A	ENST00000335725.4	+	9	1195	c.945G>A	c.(943-945)tcG>tcA	p.S315S	TDP1_ENST00000393452.3_Silent_p.S315S|TDP1_ENST00000393454.2_Silent_p.S315S|TDP1_ENST00000357382.3_Silent_p.S76S|TDP1_ENST00000555880.1_Silent_p.S315S	NM_018319.3	NP_060789.2	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	315					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|urinary_tract(1)	25		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		CTGGAGAGTCGCCAACACATT	0.418000								Repair of DNA-protein crosslinks					45	124					0	0	1	0	0
ZNF674	641339	broad.mit.edu	37	X	46360507	46360507	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:46360507C>T	ENST00000523374.1	-	6	727	c.517G>A	c.(517-519)Gga>Aga	p.G173R	ZNF674_ENST00000414387.2_Missense_Mutation_p.G167R	NM_001039891.2|NM_001146291.1|NM_001190417.1	NP_001034980.1|NP_001139763.1|NP_001177346.1	Q2M3X9	ZN674_HUMAN	zinc finger protein 674	173					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)	2						GCCTTACATCCATCATCTTTC	0.353000													8	21					0	0	1	0	0
URGCP	55665	broad.mit.edu	37	7	43918525	43918525	+	Silent	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr7:43918525C>A	ENST00000336086.6	-	4	2644	c.408G>T	c.(406-408)acG>acT	p.T136T	RP5-1165K10.1_ENST00000603700.1_Intron|URGCP_ENST00000402306.3_Silent_p.T170T|URGCP_ENST00000443736.1_Silent_p.T136T|URGCP_ENST00000497914.1_5'UTR|URGCP_ENST00000447717.3_Silent_p.T136T|URGCP_ENST00000453200.1_Silent_p.T179T|URGCP_ENST00000223341.7_Silent_p.T136T			Q8TCY9	URGCP_HUMAN	upregulator of cell proliferation	179					cell cycle	centrosome|nucleus	GTP binding			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GGTTCACTGGCGTATCAGGGG	0.522000													25	48					1.64293e-13	2.26502e-13	1	1	0
NFE2L1	4779	broad.mit.edu	37	17	46135950	46135950	+	Silent	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr17:46135950C>G	ENST00000362042.3	+	6	1882	c.1266C>G	c.(1264-1266)ctC>ctG	p.L422L	NFE2L1_ENST00000582155.1_Silent_p.L234L|NFE2L1_ENST00000585291.1_Silent_p.L392L|NFE2L1_ENST00000361665.3_Silent_p.L411L|NFE2L1_ENST00000357480.5_Silent_p.L392L|NFE2L1_ENST00000536222.1_Silent_p.L266L|NFE2L1_ENST00000583378.1_Silent_p.L223L	NM_003204.2	NP_003195.1	Q14494	NF2L1_HUMAN	nuclear factor, erythroid 2-like 1	422					anatomical structure morphogenesis|heme biosynthetic process|inflammatory response|transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			cervix(1)|endometrium(3)|kidney(9)|large_intestine(7)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CACCCCAGCTCAATGGCACAG	0.577000													26	77					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83933323	83933323	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr15:83933323G>T	ENST00000345382.2	-	4	765	c.680C>A	c.(679-681)cCc>cAc	p.P227H	BNC1_ENST00000569704.1_Missense_Mutation_p.P220H|RP11-382A20.4_ENST00000565495.1_RNA	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	227					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						TATACTGCTGGGGTTTCCTTT	0.493000													43	107					2.95478e-19	4.41661e-19	1	1	0
SMC2	10592	broad.mit.edu	37	9	106889632	106889632	+	Silent	SNP	T	T	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr9:106889632T>A	ENST00000286398.7	+	20	2949	c.2661T>A	c.(2659-2661)acT>acA	p.T887T	SMC2_ENST00000303219.8_Silent_p.T887T|SMC2_ENST00000374793.3_Silent_p.T887T|SMC2_ENST00000374787.3_Silent_p.T887T	NM_001042551.1|NM_001265602.1|NM_006444.2	NP_001036016.1|NP_001252531.1|NP_006435.2	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	887					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(14)|ovary(5)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	48						CCCAAGACACTGTAATTAAAG	0.343000													25	67					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31323098	31323098	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr18:31323098A>G	ENST00000269197.5	+	12	3286	c.3286A>G	c.(3286-3288)Acg>Gcg	p.T1096A		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1096					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						GGGTGGAAAGACGAGAACTCT	0.562000													12	54					0	0	1	0	0
GPRIN1	114787	broad.mit.edu	37	5	176026495	176026495	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr5:176026495C>T	ENST00000303991.4	-	2	518	c.341G>A	c.(340-342)gGa>gAa	p.G114E		NM_052899.2	NP_443131.2	Q7Z2K8	GRIN1_HUMAN	G protein regulated inducer of neurite outgrowth 1	114						growth cone|plasma membrane				NS(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GATGGAGGCTCCATGTGCCTC	0.612000													30	72					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41181643	41181643	+	Missense_Mutation	SNP	C	C	T	rs149083538		TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr5:41181643C>T	ENST00000263413.3	-	7	1009	c.745G>A	c.(745-747)Gac>Aac	p.D249N	C6_ENST00000475349.1_5'UTR|C6_ENST00000337836.5_Missense_Mutation_p.D249N	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	249	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GTTTTCAAGTCATCTTCTGCA	0.358000													10	30					0	0	1	0	0
DPF3	8110	broad.mit.edu	37	14	73137989	73137989	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr14:73137989G>A	ENST00000541685.1	-	9	941	c.929C>T	c.(928-930)aCg>aTg	p.T310M	DPF3_ENST00000556509.1_Intron|DPF3_ENST00000546183.1_Missense_Mutation_p.T320M|DPF3_ENST00000557704.1_5'UTR	NM_012074.3	NP_036206.3	Q92784	DPF3_HUMAN	D4, zinc and double PHD fingers, family 3	139					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)	22				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		TAAGTCCTCCGTGGTACGTGC	0.532000													16	37					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65391707	65391707	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr11:65391707C>A	ENST00000355703.3	+	14	3125	c.2586C>A	c.(2584-2586)ttC>ttA	p.F862L		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	862						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CTGTCTACTTCTGCATCTGCT	0.627000													5	13					0.00198382	0.00204132	1	1	0
PLAT	5327	broad.mit.edu	37	8	42037883	42037883	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr8:42037883G>T	ENST00000220809.4	-	11	1355	c.1099C>A	c.(1099-1101)Cac>Aac	p.H367N	PLAT_ENST00000429710.2_Missense_Mutation_p.H241N|PLAT_ENST00000429089.2_Missense_Mutation_p.H367N|PLAT_ENST00000352041.3_Missense_Mutation_p.H321N|PLAT_ENST00000270189.6_Intron|PLAT_ENST00000524009.1_Missense_Mutation_p.H278N|PLAT_ENST00000519510.1_Missense_Mutation_p.H304N	NM_000930.3	NP_000921.1	P00750	TPA_HUMAN	plasminogen activator, tissue	367	Peptidase S1.				blood coagulation|fibrinolysis|negative regulation of proteolysis|protein modification process|proteolysis	cell surface|cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(10)|skin(1)|soft_tissue(1)|urinary_tract(1)	27	all_cancers(6;3.84e-26)|all_epithelial(6;9.61e-28)|all_lung(13;7.2e-13)|Lung NSC(13;1.18e-11)|Ovarian(28;0.00438)|Prostate(17;0.0119)|Colorectal(14;0.0468)|Lung SC(25;0.211)	all_lung(54;0.000378)|Lung NSC(58;0.00145)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	BRCA - Breast invasive adenocarcinoma(8;5.23e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00135)|Colorectal(10;0.00165)|Lung(22;0.00467)|COAD - Colon adenocarcinoma(11;0.0171)|LUSC - Lung squamous cell carcinoma(45;0.024)		Alteplase(DB00009)|Aminocaproic Acid(DB00513)|Anistreplase(DB00029)|Iloprost(DB01088)|Reteplase(DB00015)|Tenecteplase(DB00031)|Tranexamic Acid(DB00302)|Urokinase(DB00013)	ACCGTCAGGTGGTGGGGCGGA	0.488000													13	155					3.27435e-08	3.93062e-08	1	1	0
CDH5	1003	broad.mit.edu	37	16	66423294	66423294	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr16:66423294G>T	ENST00000341529.3	+	5	798	c.650G>T	c.(649-651)cGa>cTa	p.R217L	CDH5_ENST00000563425.2_Missense_Mutation_p.R217L	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	217	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		AGCTTGGACCGAGAGAAGCAG	0.562000													15	36					3.32936e-07	3.84365e-07	1	1	0
PAQR8	85315	broad.mit.edu	37	6	52269010	52269010	+	Silent	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr6:52269010C>T	ENST00000442253.2	+	2	1173	c.999C>T	c.(997-999)tgC>tgT	p.C333C	PAQR8_ENST00000360726.3_Silent_p.C333C	NM_133367.4	NP_588608.1	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member VIII	333					cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|skin(1)|urinary_tract(2)	17	Lung NSC(77;0.0875)					TGGCTGCCTGCAGTGCTGCCA	0.607000													14	23					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108117798	108117798	+	Missense_Mutation	SNP	C	C	T	rs138398778		TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr11:108117798C>T	ENST00000278616.4	+	8	1394	c.1009C>T	c.(1009-1011)Cgt>Tgt	p.R337C	ATM_ENST00000452508.2_Missense_Mutation_p.R337C	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	337			R -> C (in a colorectal adenocarcinoma sample; somatic mutation).|R -> H (in a colorectal adenocarcinoma sample; somatic mutation).		cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding	p.R337C(3)|p.R337S(2)|p.F336_A340del(1)		NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TTCAGGATTTCGTAATATTGC	0.323000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			34	20					0	0	1	0	0
BCL2	596	broad.mit.edu	37	18	60985607	60985607	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr18:60985607C>T	ENST00000398117.1	-	1	1754	c.293G>A	c.(292-294)cGc>cAc	p.R98H	BCL2_ENST00000589955.1_Missense_Mutation_p.R98H|BCL2_ENST00000333681.4_Missense_Mutation_p.R98H|BCL2_ENST00000444484.1_Missense_Mutation_p.R98H	NM_000633.2	NP_000624.2	P10415	BCL2_HUMAN	B-cell CLL/lymphoma 2	98					activation of pro-apoptotic gene products|anti-apoptosis|apoptosis in response to endoplasmic reticulum stress|B cell proliferation|B cell receptor signaling pathway|defense response to virus|female pregnancy|humoral immune response|induction of apoptosis by intracellular signals|negative regulation of cellular pH reduction|negative regulation of mitochondrial depolarization|negative regulation of neuron apoptosis|neuron apoptosis|positive regulation of B cell proliferation|positive regulation of cell growth|protein polyubiquitination|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|regulation of transmembrane transporter activity|release of cytochrome c from mitochondria|response to cytokine stimulus|response to DNA damage stimulus|response to drug|response to iron ion|response to nicotine|response to toxin	endoplasmic reticulum membrane|mitochondrial outer membrane|nuclear membrane|pore complex	BH3 domain binding|channel activity|protease binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(106)|kidney(1)|large_intestine(1)|lung(3)	113		all_hematologic(56;1.18e-20)|Prostate(75;0.0872)		Lung(128;0.0234)|READ - Rectum adenocarcinoma(59;0.0935)	Docetaxel(DB01248)|Fludarabine(DB01073)|Melatonin(DB01065)|Paclitaxel(DB01229)|Rasagiline(DB01367)	GCCGGCCTGGCGGAGGGTCAG	0.761000			T	IGH@	"""NHL, CLL"""								17	36					0	0	1	0	0
FAM199X	139231	broad.mit.edu	37	X	103411599	103411599	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:103411599G>T	ENST00000493442.1	+	1	299	c.133G>T	c.(133-135)Gac>Tac	p.D45Y		NM_207318.3	NP_997201.1	Q6PEV8	F199X_HUMAN	family with sequence similarity 199, X-linked	45										breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(1)|skin(1)	11						GGACATCAGCGACTTCGGCTG	0.662000													7	46					0.000157383	0.000167404	1	1	0
STAG3L2	442582	broad.mit.edu	37	7	74303888	74303888	+	RNA	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr7:74303888C>T	ENST00000423186.1	-	0	414							P0CL84	ST3L2_HUMAN								nucleus	binding			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|pancreas(1)	5						GACGATGTACCGCTTGGGACC	0.408000													9	155					0	0	1	0	0
AMER1	139285	broad.mit.edu	37	X	63410915	63410915	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:63410915G>T	ENST00000330258.3	-	2	2524	c.2252C>A	c.(2251-2253)cCt>cAt	p.P751H	AMER1_ENST00000374869.3_Missense_Mutation_p.P751H|AMER1_ENST00000403336.1_Missense_Mutation_p.P751H	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)|p.E752fs*1(2)									TGGATCTTCAGGGGGTGAATA	0.512000													17	36					9.16793e-09	1.13204e-08	1	1	0
LAMB1	3912	broad.mit.edu	37	7	107580477	107580477	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr7:107580477C>T	ENST00000393561.1	-	23	3974	c.3790G>A	c.(3790-3792)Gca>Aca	p.A1264T	LAMB1_ENST00000222399.6_Missense_Mutation_p.A1240T			P07942	LAMB1_HUMAN	laminin, beta 1	1240	Domain II.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGTGGCTCTGCTGCGGGGCTC	0.468000													39	89					0	0	1	0	0
MYOM1	8736	broad.mit.edu	37	18	3188808	3188808	+	Nonsense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr18:3188808C>A	ENST00000356443.4	-	4	1042	c.709G>T	c.(709-711)Gaa>Taa	p.E237*	MYOM1_ENST00000261606.7_Nonsense_Mutation_p.E237*|MYOM1_ENST00000400569.3_Nonsense_Mutation_p.E237*	NM_003803.3|NM_019856.1	NP_003794.3|NP_062830.1	P52179	MYOM1_HUMAN	myomesin 1	237						striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GACTTCTTTTCAGAAGTTTCT	0.473000													14	26					4.3838e-07	5.01893e-07	1	1	0
MUC16	94025	broad.mit.edu	37	19	9063857	9063857	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr19:9063857G>C	ENST00000397910.4	-	3	23792	c.23589C>G	c.(23587-23589)atC>atG	p.I7863M		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7865	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.I7863I(1)|p.I3496I(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTTCCTTGGAGATCTCAGTAG	0.552000													37	38					0	0	1	0	0
UFSP2	55325	broad.mit.edu	37	4	186329175	186329175	+	Nonsense_Mutation	SNP	C	C	A	rs139834558		TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr4:186329175C>A	ENST00000264689.6	-	9	1152	c.1036G>T	c.(1036-1038)Gga>Tga	p.G346*		NM_018359.3	NP_060829.2	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	346						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		TGCCGCGATCCGACAAATGTT	0.393000													16	52					3.52763e-06	3.88313e-06	1	1	0
OSR1	130497	broad.mit.edu	37	2	19553070	19553070	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:19553070C>A	ENST00000536433.1	-	1	3607	c.497G>T	c.(496-498)cGt>cTt	p.R166L	OSR1_ENST00000272223.2_Missense_Mutation_p.R166L			Q8TAX0	OSR1_HUMAN	odd-skipped related transciption factor 1	166					chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|heart development|mesangial cell development|mesonephric duct morphogenesis|metanephric cap mesenchymal cell proliferation involved in metanephros development|metanephric glomerulus vasculature development|metanephric interstitial cell development|metanephric mesenchymal cell differentiation|metanephric nephron tubule development|metanephric smooth muscle tissue development|middle ear morphogenesis|negative regulation of apoptosis|negative regulation of nephron tubule epithelial cell differentiation|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|pattern specification involved in metanephros development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of gastrulation|positive regulation of transcription from RNA polymerase II promoter|pronephros development|renal vesicle progenitor cell differentiation|specification of anterior mesonephric tubule identity|specification of posterior mesonephric tubule identity|stem cell differentiation|transcription, DNA-dependent|ureter urothelium development|ureteric bud development	nucleolus	nucleic acid binding|zinc ion binding			breast(1)|large_intestine(2)|lung(4)|ovary(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	Acute lymphoblastic leukemia(84;0.221)				GGAAGGCAGACGTCCCCTTGT	0.602000													59	27					2.44813e-32	4.16329e-32	1	1	0
NES	10763	broad.mit.edu	37	1	156640382	156640382	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:156640382G>A	ENST00000368223.3	-	4	3730	c.3598C>T	c.(3598-3600)Cct>Tct	p.P1200S		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1200	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CAAGGTGAAGGGGCATCACTT	0.652000													88	47					0	0	1	0	0
ARHGEF40	55701	broad.mit.edu	37	14	21548906	21548906	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr14:21548906G>T	ENST00000298694.4	+	12	2588	c.2461G>T	c.(2461-2463)Gag>Tag	p.E821*	ARHGEF40_ENST00000298693.3_Nonsense_Mutation_p.E821*			Q8TER5	ARH40_HUMAN	Rho guanine nucleotide exchange factor (GEF) 40	821					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						GCAGGAGACAGAGCTGCGATT	0.632000													23	41					9.95505e-16	1.40658e-15	1	1	0
NBAS	51594	broad.mit.edu	37	2	15618411	15618411	+	Silent	SNP	T	T	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:15618411T>C	ENST00000281513.5	-	13	1111	c.1086A>G	c.(1084-1086)ccA>ccG	p.P362P	NBAS_ENST00000441750.1_Silent_p.P362P	NM_015909.3	NP_056993.2	A2RRP1	NBAS_HUMAN	neuroblastoma amplified sequence	362										NS(4)|breast(4)|central_nervous_system(3)|endometrium(6)|kidney(5)|large_intestine(12)|liver(1)|lung(54)|ovary(2)|pancreas(3)|prostate(9)|skin(6)|stomach(3)	112						CATCATAGCCTGGCTAAATAT	0.323000													16	12					0	0	1	0	0
PAQR8	85315	broad.mit.edu	37	6	52269009	52269009	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr6:52269009G>C	ENST00000442253.2	+	2	1172	c.998G>C	c.(997-999)tGc>tCc	p.C333S	PAQR8_ENST00000360726.3_Missense_Mutation_p.C333S	NM_133367.4	NP_588608.1	Q8TEZ7	MPRB_HUMAN	progestin and adipoQ receptor family member VIII	333					cell differentiation|multicellular organismal development|oogenesis	integral to membrane|plasma membrane	receptor activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|skin(1)|urinary_tract(2)	17	Lung NSC(77;0.0875)					CTGGCTGCCTGCAGTGCTGCC	0.602000													14	23					0	0	1	0	0
DPY19L3	147991	broad.mit.edu	37	19	32944130	32944130	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr19:32944130G>T	ENST00000342179.5	+	9	1150	c.935G>T	c.(934-936)gGa>gTa	p.G312V	DPY19L3_ENST00000586987.1_Missense_Mutation_p.G312V|DPY19L3_ENST00000392250.2_Missense_Mutation_p.G312V	NM_207325.2	NP_997208.2	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3 (C. elegans)	312						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(4)|pancreas(1)	32	Esophageal squamous(110;0.162)					ATGATTCTTGGATCACTGCTT	0.333000													18	42					7.05477e-17	1.01703e-16	1	1	0
CLPS	1208	broad.mit.edu	37	6	35762924	35762924	+	Nonstop_Mutation	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr6:35762924C>G	ENST00000259938.2	-	3	360	c.338G>C	c.(337-339)tGa>tCa	p.*113S		NM_001832.3	NP_001823.1	P04118	COL_HUMAN	colipase, pancreatic	0					lipid catabolic process|lipid digestion|retinoid metabolic process|steroid metabolic process	extracellular region				large_intestine(2)|lung(2)|prostate(1)	5						TGGGCAGTCTCACTGCTTGGA	0.627000													18	96					0	0	1	0	0
P2RX1	5023	broad.mit.edu	37	17	3806863	3806863	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr17:3806863G>T	ENST00000225538.3	-	6	861	c.587C>A	c.(586-588)cCa>cAa	p.P196Q		NM_002558.2	NP_002549.1	P51575	P2RX1_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 1	196					platelet activation	integral to plasma membrane	calcium channel activity|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)	13				LUAD - Lung adenocarcinoma(2;1.9e-05)|Lung(3;0.0173)		CTTGAAGCGTGGAAAGCTGAT	0.607000													30	52					3.1745e-13	4.33441e-13	1	1	0
SEC24B	10427	broad.mit.edu	37	4	110434945	110434945	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr4:110434945G>T	ENST00000265175.5	+	10	2001	c.1946G>T	c.(1945-1947)gGa>gTa	p.G649V	SEC24B_ENST00000399100.2_Missense_Mutation_p.G614V|SEC24B_ENST00000504968.2_Missense_Mutation_p.G679V	NM_006323.2	NP_006314.2	O95487	SC24B_HUMAN	SEC24 family member B	649					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		CGATCTTATGGAGAGCCTCAT	0.358000													46	107					4.25531e-23	6.78938e-23	1	1	0
DPH2	1802	broad.mit.edu	37	1	44436377	44436377	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:44436377G>T	ENST00000255108.3	+	2	429	c.257G>T	c.(256-258)gGc>gTc	p.G86V	DPH2_ENST00000412950.2_Missense_Mutation_p.A26S|DPH2_ENST00000529729.1_3'UTR|DPH2_ENST00000396758.2_Missense_Mutation_p.G86V	NM_001384.4	NP_001375.2	Q9BQC3	DPH2_HUMAN	DPH2 homolog (S. cerevisiae)	86					peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm		p.G86D(1)		autonomic_ganglia(1)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(2)|skin(1)	19	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				ACAGCCTACGGCAGGTGTGAA	0.562000													111	133					9.63447e-60	1.67864e-59	1	1	0
AIFM1	9131	broad.mit.edu	37	X	129289263	129289263	+	Splice_Site	SNP	T	T	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:129289263T>A	ENST00000319908.3	-	2	329		c.e2-2		AIFM1_ENST00000287295.3_Intron|AIFM1_ENST00000346424.2_Intron|AIFM1_ENST00000535724.1_Intron	NM_145812.2	NP_665811.1	O95831	AIFM1_HUMAN	apoptosis-inducing factor, mitochondrion-associated, 1						activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(4)|prostate(2)|urinary_tract(1)	30						ACTGCACAACTGTAGGTAAAG	0.403000													40	100					0	0	1	0	0
RTN4R	65078	broad.mit.edu	37	22	20230097	20230097	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr22:20230097C>A	ENST00000043402.7	-	2	997	c.559G>T	c.(559-561)Ggc>Tgc	p.G187C		NM_023004.5	NP_075380.1	Q9BZR6	RTN4R_HUMAN	reticulon 4 receptor	187					axonogenesis|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway	anchored to membrane|cell surface|endoplasmic reticulum|plasma membrane	protein binding|receptor activity			lung(1)|ovary(1)|prostate(1)	3	Colorectal(54;0.0993)					ATGCGGTTGCCGTGCAGGAAG	0.662000													25	59					6.12954e-19	9.11407e-19	1	1	0
NCAPD3	23310	broad.mit.edu	37	11	134055339	134055339	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr11:134055339T>A	ENST00000534548.2	-	17	2192	c.2128A>T	c.(2128-2130)Act>Tct	p.T710S	RP11-700F16.3_ENST00000531710.1_RNA	NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	710					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		TCCGTGCCAGTGTGAGATATT	0.413000													39	20					0	0	1	0	0
PLCG2	5336	broad.mit.edu	37	16	81888091	81888091	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr16:81888091C>A	ENST00000359376.3	+	3	450	c.236C>A	c.(235-237)tCc>tAc	p.S79Y	PLCG2_ENST00000565400.1_3'UTR	NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	79	PH.				intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						GGGAAGAACTCCAAAGATTTC	0.468000													41	60					3.54909e-21	5.41904e-21	1	1	0
TM4SF20	79853	broad.mit.edu	37	2	228235643	228235643	+	Silent	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:228235643G>A	ENST00000304568.3	-	2	274	c.237C>T	c.(235-237)aaC>aaT	p.N79N		NM_024795.3	NP_079071.2	Q53R12	T4S20_HUMAN	transmembrane 4 L six family member 20	79						integral to membrane|plasma membrane				breast(1)|kidney(2)|large_intestine(1)|lung(4)|stomach(2)	10		Renal(207;0.025)|all_lung(227;0.123)|Esophageal squamous(248;0.23)|all_hematologic(139;0.248)		Epithelial(121;3.8e-11)|all cancers(144;2.57e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)		CAGTTCTGTTGTTGCAGCACG	0.443000													278	283					0	0	1	0	0
RB1CC1	9821	broad.mit.edu	37	8	53540663	53540663	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr8:53540663G>C	ENST00000025008.5	-	22	5088	c.4565C>G	c.(4564-4566)aCt>aGt	p.T1522S	RB1CC1_ENST00000521611.1_Intron|RB1CC1_ENST00000539297.1_Missense_Mutation_p.T1522S|RB1CC1_ENST00000435644.2_Missense_Mutation_p.T1522S	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	1522					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				AGGACTAACAGTAAATAACAC	0.368000													31	57					0	0	1	0	0
VGLL3	389136	broad.mit.edu	37	3	87017994	87017994	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr3:87017994C>G	ENST00000398399.2	-	3	1046	c.683G>C	c.(682-684)cGg>cCg	p.R228P	VGLL3_ENST00000383698.3_Missense_Mutation_p.R228P	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	228	His-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		GTGGTGGTGCCGCATGTACAC	0.607000													10	61					0	0	1	0	0
LPA	4018	broad.mit.edu	37	6	161032688	161032688	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr6:161032688T>A	ENST00000447678.1	-	17	2629	c.2509A>T	c.(2509-2511)Aca>Tca	p.T837S	LPA_ENST00000316300.5_Missense_Mutation_p.T837S	NM_005577.2	NP_005568.2	P08519	APOA_HUMAN	lipoprotein, Lp(a)	3345	Kringle 8.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|lung(54)|ovary(4)|pancreas(1)|prostate(2)|skin(10)|stomach(1)|urinary_tract(1)	107		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	GTGGAGTATGTGCCTCGATAA	0.493000													14	172					0	0	1	0	0
ZNF780B	163131	broad.mit.edu	37	19	40541447	40541447	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr19:40541447G>C	ENST00000434248.1	-	5	1384	c.1319C>G	c.(1318-1320)tCc>tGc	p.S440C	ZNF780B_ENST00000221355.6_Missense_Mutation_p.S292C	NM_001005851.2	NP_001005851.1	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	440					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TTTCTCATTGGAATGAATTTT	0.378000													66	114					0	0	1	0	0
FBXL6	26233	broad.mit.edu	37	8	145579642	145579642	+	Silent	SNP	T	T	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr8:145579642T>C	ENST00000331890.5	-	8	1522	c.1458A>G	c.(1456-1458)acA>acG	p.T486T	FBXL6_ENST00000526524.1_Intron|FBXL6_ENST00000455319.2_Silent_p.T480T	NM_012162.2	NP_036294.1	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6	486					proteolysis		ubiquitin-protein ligase activity			endometrium(1)|lung(3)|ovary(1)	5	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			CAGTGCTTGGTGTGACCCGGG	0.637000													6	88					0	0	1	0	0
ANGPTL1	9068	broad.mit.edu	37	1	178834215	178834215	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:178834215G>T	ENST00000234816.2	-	3	1144	c.697C>A	c.(697-699)Ctg>Atg	p.L233M	RALGPS2_ENST00000324778.4_Intron|RALGPS2_ENST00000367635.3_Intron|ANGPTL1_ENST00000367629.1_Missense_Mutation_p.L233M|RALGPS2_ENST00000367634.2_Intron	NM_004673.3	NP_004664.1	O95841	ANGL1_HUMAN	angiopoietin-like 1	233						extracellular space	receptor binding	p.L233V(1)		breast(2)|endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)	14						CCTCCCAGCAGACCAGGAGTA	0.498000													63	80					8.72158e-25	1.43175e-24	1	1	0
TP53BP1	7158	broad.mit.edu	37	15	43699769	43699769	+	Splice_Site	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr15:43699769C>T	ENST00000263801.3	-	28	5984		c.e28-1		TP53BP1_ENST00000382039.3_Splice_Site|TP53BP1_ENST00000450115.2_Splice_Site|TP53BP1_ENST00000382044.4_Splice_Site	NM_005657.2	NP_005648.1	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1						double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			breast(4)|endometrium(5)|kidney(7)|large_intestine(22)|lung(13)|ovary(4)|pancreas(2)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(3)	72		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		AAAGCAATATCTGCAAGGAGC	0.488000								Other conserved DNA damage response genes					14	77					0	0	1	0	0
TAT	6898	broad.mit.edu	37	16	71610119	71610119	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr16:71610119G>T	ENST00000355962.4	-	2	333	c.200C>A	c.(199-201)cCa>cAa	p.P67Q	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	67					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	GTTTGGATTTGGTTTCACCTT	0.498000													6	28					8.12818e-05	8.71096e-05	1	1	0
TECRL	253017	broad.mit.edu	37	4	65146772	65146772	+	Silent	SNP	T	T	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr4:65146772T>A	ENST00000381210.3	-	11	1061	c.951A>T	c.(949-951)acA>acT	p.T317T	TECRL_ENST00000507440.1_Silent_p.T317T	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	317					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						GCAGTGTTTGTGTCATGACTG	0.279000													11	35					0	0	1	0	0
ZNF155	7711	broad.mit.edu	37	19	44500947	44500947	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr19:44500947A>T	ENST00000270014.2	+	5	1066	c.938A>T	c.(937-939)gAa>gTa	p.E313V	ZNF155_ENST00000407951.2_Missense_Mutation_p.E324V|ZNF155_ENST00000590615.1_Missense_Mutation_p.E313V	NM_001260487.1|NM_198089.2	NP_001247416.1|NP_932355.2	Q12901	ZN155_HUMAN	zinc finger protein 155	313						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	15		Prostate(69;0.0352)				CACACAGGAGAAAAACCATTT	0.403000													44	99					0	0	1	0	0
AIPL1	23746	broad.mit.edu	37	17	6328811	6328811	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr17:6328811G>T	ENST00000381129.3	-	6	1204	c.1124C>A	c.(1123-1125)cCc>cAc	p.P375H	AIPL1_ENST00000576776.1_Missense_Mutation_p.P351H|AIPL1_ENST00000576307.1_Missense_Mutation_p.P315H|AIPL1_ENST00000575265.1_3'UTR|AIPL1_ENST00000574506.1_Missense_Mutation_p.P363H|AIPL1_ENST00000570466.1_Missense_Mutation_p.P353H|AIPL1_ENST00000250087.5_Missense_Mutation_p.P312H	NM_001033055.1|NM_014336.3	NP_001028227.1|NP_055151.3	Q9NZN9	AIPL1_HUMAN	aryl hydrocarbon receptor interacting protein-like 1	375					protein farnesylation|protein folding|visual perception	cytoplasm|nucleus	farnesylated protein binding|unfolded protein binding			NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|skin(1)	12				COAD - Colon adenocarcinoma(228;0.141)		TGGGGACGGgggtggctctgt	0.672000													20	39					2.94398e-08	3.58837e-08	1	1	0
ASTN1	460	broad.mit.edu	37	1	176927506	176927506	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:176927506C>A	ENST00000367654.2	-	10	1748	c.1735G>T	c.(1735-1737)Gtg>Ttg	p.V579L	ASTN1_ENST00000424564.2_Missense_Mutation_p.V571L|ASTN1_ENST00000367657.3_Missense_Mutation_p.V571L|ASTN1_ENST00000361833.2_Missense_Mutation_p.V571L|ASTN1_ENST00000281881.3_5'UTR			O14525	ASTN1_HUMAN	astrotactin 1	579					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						TCCTCCATCACAGTCATGTCC	0.527000													42	37					1.8453e-21	2.83278e-21	1	1	0
ADIPOQ	9370	broad.mit.edu	37	3	186570860	186570860	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr3:186570860G>T	ENST00000412955.2	+	2	154	c.13G>T	c.(13-15)Gga>Tga	p.G5*	ADIPOQ-AS1_ENST00000422718.1_RNA|ADIPOQ_ENST00000320741.2_Nonsense_Mutation_p.G5*|ADIPOQ_ENST00000444204.2_Nonsense_Mutation_p.G5*			Q15848	ADIPO_HUMAN	adiponectin, C1Q and collagen domain containing	5					brown fat cell differentiation|cellular response to drug|cellular response to insulin stimulus|detection of oxidative stress|fatty acid beta-oxidation|generation of precursor metabolites and energy|glucose homeostasis|glucose metabolic process|low-density lipoprotein particle clearance|negative regulation of blood pressure|negative regulation of DNA biosynthetic process|negative regulation of ERK1 and ERK2 cascade|negative regulation of eukaryotic cell surface binding|negative regulation of fat cell differentiation|negative regulation of gluconeogenesis|negative regulation of granulocyte differentiation|negative regulation of heterotypic cell-cell adhesion|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of inflammatory response|negative regulation of intracellular protein transport|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|negative regulation of macrophage differentiation|negative regulation of MAP kinase activity|negative regulation of phagocytosis|negative regulation of platelet-derived growth factor receptor signaling pathway|negative regulation of protein autophosphorylation|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|negative regulation of synaptic transmission|negative regulation of transcription, DNA-dependent|negative regulation of tumor necrosis factor production|negative regulation of tumor necrosis factor-mediated signaling pathway|positive regulation of cAMP-dependent protein kinase activity|positive regulation of cholesterol efflux|positive regulation of fatty acid metabolic process|positive regulation of glucose import|positive regulation of glycogen (starch) synthase activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-8 production|positive regulation of metanephric glomerular visceral epithelial cell development|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myeloid cell apoptosis|positive regulation of protein kinase A signaling cascade|positive regulation of renal albumin absorption|protein homooligomerization|protein localization in plasma membrane|response to glucose stimulus|response to tumor necrosis factor	collagen|endoplasmic reticulum|extracellular space	cytokine activity|eukaryotic cell surface binding|hormone activity|protein homodimerization activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|skin(2)	16	all_cancers(143;1.2e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.47e-19)	GBM - Glioblastoma multiforme(93;0.0776)		GCTGTTGCTGGGAGCTGTTCT	0.597000													23	21					4.4004e-07	5.01893e-07	1	1	0
SIRT6	51548	broad.mit.edu	37	19	4174896	4174896	+	Nonstop_Mutation	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr19:4174896C>G	ENST00000594279.1	-	8	748	c.530G>C	c.(529-531)tGa>tCa	p.*177S	SIRT6_ENST00000381935.3_Missense_Mutation_p.M190I|SIRT6_ENST00000601488.1_Nonstop_Mutation_p.*188S|SIRT6_ENST00000305232.6_Missense_Mutation_p.M235I|SIRT6_ENST00000337491.2_Missense_Mutation_p.M262I			Q8N6T7	SIRT6_HUMAN	sirtuin 6	0	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation	nuclear telomeric heterochromatin|nucleoplasm	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity|NAD+ binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|protein binding|zinc ion binding			central_nervous_system(1)|kidney(1)|lung(4)|ovary(1)|skin(1)	8		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.023)|STAD - Stomach adenocarcinoma(1328;0.18)		TGAGCCGGGTCATGACCTCGT	0.721000													14	18					0	0	1	0	0
HIST1H1D	3007	broad.mit.edu	37	6	26234599	26234599	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr6:26234599T>C	ENST00000244534.5	-	1	617	c.563A>G	c.(562-564)aAg>aGg	p.K188R		NM_005320.2	NP_005311.1	P16402	H13_HUMAN	histone cluster 1, H1d	188					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				AGCTGGACTCTTGGCAGCTTT	0.522000													47	67					0	0	1	0	0
C21orf59	56683	broad.mit.edu	37	21	33976537	33976537	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr21:33976537G>C	ENST00000382549.4	-	4	774	c.432C>G	c.(430-432)gaC>gaG	p.D144E	C21orf59_ENST00000540881.1_Missense_Mutation_p.D88E|C21orf59_ENST00000290155.3_Missense_Mutation_p.D144E|C21ORF59_ENST00000607686.1_Missense_Mutation_p.P122A			P57076	CU059_HUMAN	chromosome 21 open reading frame 59	144						cytosol|nucleus				endometrium(2)|large_intestine(1)|prostate(1)|skin(1)	5						CTCGAAGCTGGTCCAAGGCAT	0.498000													23	51					0	0	1	0	0
WRAP73	49856	broad.mit.edu	37	1	3548811	3548811	+	Missense_Mutation	SNP	A	A	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:3548811A>C	ENST00000378322.3	-	10	1072	c.1014T>G	c.(1012-1014)ttT>ttG	p.F338L	WRAP73_ENST00000270708.7_Missense_Mutation_p.F338L			Q9P2S5	WRP73_HUMAN	WD repeat containing, antisense to TP73	338						centrosome	protein binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(3)|pancreas(1)	12						TGTCAGGACTAAATGCCAGCA	0.527000													34	87					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140517376	140517376	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr5:140517376C>A	ENST00000231134.5	+	1	2577	c.2360C>A	c.(2359-2361)gCc>gAc	p.A787D		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		787					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AAAACTGCTGCCTTCCGGAAT	0.468000													51	105					5.22555e-25	8.62824e-25	1	1	0
PAK7	57144	broad.mit.edu	37	20	9525092	9525092	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr20:9525092G>T	ENST00000378429.3	-	9	2339	c.1793C>A	c.(1792-1794)cCg>cAg	p.P598Q	PAK7_ENST00000378423.1_Missense_Mutation_p.P598Q|PAK7_ENST00000353224.5_Missense_Mutation_p.P598Q	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	598	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			TTTCCTCTTCGGCACCTCTTT	0.448000													38	97					3.28013e-08	3.93062e-08	1	1	0
TRIM51HP	440041	broad.mit.edu	37	11	55062948	55062948	+	RNA	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr11:55062948C>A	ENST00000526016.1	-	0	689					NR_038174.2																						AGAGTAGCTCCACATCTGCTT	0.438000													14	42					4.3838e-07	5.01893e-07	1	1	0
ELF4	2000	broad.mit.edu	37	X	129205072	129205072	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:129205072C>A	ENST00000308167.5	-	7	1131	c.752G>T	c.(751-753)tGg>tTg	p.W251L	ELF4_ENST00000335997.7_Missense_Mutation_p.W251L	NM_001421.3	NP_001412.1	Q99607	ELF4_HUMAN	E74-like factor 4 (ets domain transcription factor)	251					natural killer cell proliferation|NK T cell proliferation|positive regulation of transcription from RNA polymerase II promoter	PML body	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	22						CTGCTTCCCCCACAGCTTGGA	0.527000			T	ERG	AML								75	152					1.76847e-28	2.95439e-28	1	1	0
PLD5	200150	broad.mit.edu	37	1	242271042	242271042	+	Silent	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:242271042G>A	ENST00000442594.2	-	9	1403	c.894C>T	c.(892-894)ccC>ccT	p.P298P	PLD5_ENST00000427495.1_Silent_p.P328P|PLD5_ENST00000536534.1_Silent_p.P390P	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	390						integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			TAAACGTAAGGGGATCAGTTT	0.368000													25	167					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11300470	11300470	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:11300470T>A	ENST00000361445.4	-	11	1752	c.1676A>T	c.(1675-1677)aAg>aTg	p.K559M		NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	559					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						GGCCAGGCCCTTGGGCATGCC	0.587000													6	80					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	31039405	31039405	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr19:31039405G>A	ENST00000355537.3	+	4	3026	c.2879G>A	c.(2878-2880)aGt>aAt	p.S960N		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	960					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GAGAAACCCAGTGGCAAGTCC	0.572000													85	161					0	0	1	0	0
CCT6P1	643253	broad.mit.edu	37	7	65222986	65222986	+	RNA	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr7:65222986G>T	ENST00000442266.1	+	0	578																											GAATTCTGGCGTTTTTTACAA	0.289000													4	17					1	1	1	1	0
ZNF716	441234	broad.mit.edu	37	7	57528601	57528601	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr7:57528601T>C	ENST00000420713.1	+	4	546	c.434T>C	c.(433-435)gTt>gCt	p.V145A		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						TATAATTATGTTAACCAATGT	0.348000													10	32					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53610740	53610740	+	Silent	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:53610740C>A	ENST00000342160.3	-	41	5755	c.5298G>T	c.(5296-5298)ctG>ctT	p.L1766L	HUWE1_ENST00000262854.6_Silent_p.L1766L			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	1766					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						CAGGGACTCCCAGCATGCTCA	0.522000													24	66					1.10513e-12	1.48046e-12	1	1	0
NALCN	259232	broad.mit.edu	37	13	101717798	101717798	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr13:101717798C>A	ENST00000251127.6	-	40	4643	c.4562G>T	c.(4561-4563)aGg>aTg	p.R1521M		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	1521						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					ATTGTGGAGCCTCTCCATTTC	0.577000													30	71					1.74807e-11	2.30908e-11	1	1	0
AS3MT	57412	broad.mit.edu	37	10	104632936	104632936	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr10:104632936A>G	ENST00000369880.3	+	5	481	c.404A>G	c.(403-405)tAc>tGc	p.Y135C	C10ORF32_ENST00000299353.6_3'UTR	NM_020682.3	NP_065733.2	Q9HBK9	AS3MT_HUMAN	arsenic (+3 oxidation state) methyltransferase	135				Y -> N (in Ref. 2; AAG09731).	arsonoacetate metabolic process|toxin metabolic process	cytosol	arsenite methyltransferase activity|methylarsonite methyltransferase activity			large_intestine(1)|lung(6)	7		Colorectal(252;0.122)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;5.87e-09)|all cancers(201;1.58e-07)|BRCA - Breast invasive adenocarcinoma(275;0.223)		ATTCATGGCTACATTGAGAAG	0.358000													6	90					0	0	1	0	0
IFNB1	3456	broad.mit.edu	37	9	21077632	21077632	+	Silent	SNP	G	G	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr9:21077632G>C	ENST00000380232.2	-	1	311	c.237C>G	c.(235-237)acC>acG	p.T79T		NM_002176.2	NP_002167.1	P01574	IFNB_HUMAN	interferon, beta 1, fibroblast	79					activation of caspase activity|B cell proliferation|blood coagulation|cellular response to exogenous dsRNA|defense response to virus|induction of apoptosis|natural killer cell activation|negative regulation of cell proliferation|negative regulation of T cell differentiation|negative regulation of T-helper 2 cell cytokine production|negative regulation of viral genome replication|negative regulation of viral transcription|negative regulation of virion penetration into host cell|positive regulation of innate immune response|positive regulation of transcription from RNA polymerase II promoter|regulation of MHC class I biosynthetic process|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding|transcription corepressor activity			breast(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)	12				GBM - Glioblastoma multiforme(5;7.45e-142)|Lung(24;2.42e-17)|LUSC - Lung squamous cell carcinoma(38;7.17e-11)	Interferon beta-1a(DB00060)|Interferon beta-1b(DB00068)	TCTCATAGATGGTCAATGCGG	0.468000													61	120					0	0	1	0	0
PRPF8	10594	broad.mit.edu	37	17	1576725	1576725	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr17:1576725G>A	ENST00000572621.1	-	22	3848	c.3583C>T	c.(3583-3585)Cgc>Tgc	p.R1195C	PRPF8_ENST00000304992.6_Missense_Mutation_p.R1195C			Q6P2Q9	PRP8_HUMAN	pre-mRNA processing factor 8	1195						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(13)|lung(24)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	77				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GGCAGGATGCGGCACTCGAAG	0.577000													25	61					0	0	1	0	0
ACVR1C	130399	broad.mit.edu	37	2	158397655	158397655	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:158397655A>T	ENST00000243349.7	-	7	1532	c.1172T>A	c.(1171-1173)aTc>aAc	p.I391N	ACVR1C_ENST00000335450.7_Missense_Mutation_p.I311N|ACVR1C_ENST00000409680.3_Missense_Mutation_p.I341N|ACVR1C_ENST00000348328.5_Missense_Mutation_p.I234N	NM_145259.2	NP_660302.2	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC	391	Protein kinase.				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	42						AACAGAATAGATGTCAGCTCG	0.388000													80	71					0	0	1	0	0
TBX20	57057	broad.mit.edu	37	7	35289651	35289651	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr7:35289651C>A	ENST00000408931.3	-	2	818	c.292G>T	c.(292-294)Gcc>Tcc	p.A98S		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	98						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						GCAATTTTGGCCATTTCCTCA	0.582000													12	31					6.42651e-13	8.73268e-13	1	1	0
MLH1	4292	broad.mit.edu	37	3	37035149	37035149	+	Missense_Mutation	SNP	G	G	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr3:37035149G>C	ENST00000231790.2	+	1	327	c.111G>C	c.(109-111)gaG>gaC	p.E37D		NM_000249.3|NM_001258273.1	NP_000240.1|NP_001245202.1	P40692	MLH1_HUMAN	mutL homolog 1	37			E -> ELNH (found in an endometrial cancer sample; somatic mutation).		mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(12)|kidney(2)|large_intestine(54)|lung(13)|oesophagus(7)|ovary(6)|pancreas(5)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	127						AGATGATTGAGAACTGGTACG	0.607000		1	"""D, Mis, N, F, S"""		"""colorectal, endometrial, ovarian, CNS"""	"""colorectal, endometrial, ovarian, CNS"""		Mismatch excision repair (MMR)	Turcot syndrome;Muir-Torre syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				14	48					0	0	1	0	0
DHFRL1	200895	broad.mit.edu	37	3	93780124	93780124	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr3:93780124T>C	ENST00000394221.2	-	2	681	c.232A>G	c.(232-234)Aga>Gga	p.R78G	DHFRL1_ENST00000481631.1_Intron|DHFRL1_ENST00000314636.2_Missense_Mutation_p.R78G	NM_001195643.1	NP_001182572.1	Q86XF0	DYRL1_HUMAN	dihydrofolate reductase-like 1	78	DHFR.				glycine biosynthetic process|nucleotide biosynthetic process|one-carbon metabolic process		dihydrofolate reductase activity|NADP binding			kidney(1)|large_intestine(2)|lung(3)|skin(1)|stomach(1)	8						TTGAGTTCTCTGCTGAGAACT	0.398000													14	166					0	0	1	0	0
USP7	7874	broad.mit.edu	37	16	9004618	9004618	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr16:9004618C>A	ENST00000344836.4	-	11	1343	c.1145G>T	c.(1144-1146)gGg>gTg	p.G382V	USP7_ENST00000535863.1_Missense_Mutation_p.G283V|USP7_ENST00000381886.4_Missense_Mutation_p.G366V	NM_003470.2	NP_003461.2	Q93009	UBP7_HUMAN	ubiquitin specific peptidase 7 (herpes virus-associated)	382					interspecies interaction between organisms|multicellular organismal development|protein deubiquitination|regulation of sequence-specific DNA binding transcription factor activity|ubiquitin-dependent protein catabolic process	cytoplasm|PML body	cysteine-type endopeptidase activity|p53 binding|protein C-terminus binding|transcription factor binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(13)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	48						GCCATGTTCCCCAGCGTCGTA	0.358000													12	38					9.31168e-06	1.01712e-05	1	1	0
SLC14A2	8170	broad.mit.edu	37	18	43249417	43249417	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr18:43249417C>G	ENST00000255226.6	+	16	2999	c.2183C>G	c.(2182-2184)gCa>gGa	p.A728G	RP11-116O18.3_ENST00000589510.1_RNA|SLC14A2_ENST00000586448.1_Missense_Mutation_p.A728G|SLC14A2_ENST00000589658.1_Missense_Mutation_p.A205G	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	728						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CTGCAGCCTGCATCCGCCATG	0.557000													35	122					0	0	1	0	0
NCL	4691	broad.mit.edu	37	2	232322438	232322438	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:232322438C>T	ENST00000322723.4	-	9	1603	c.1363G>A	c.(1363-1365)Gat>Aat	p.D455N		NM_005381.2	NP_005372.2	P19338	NUCL_HUMAN	nucleolin	455	RRM 2.				angiogenesis	cell cortex|nucleolus|ribonucleoprotein complex	nucleotide binding|protein C-terminus binding|RNA binding|telomeric DNA binding	p.D455N(1)		breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(7)|ovary(2)|pancreas(2)|prostate(2)|skin(3)	35		Ovarian(221;1.34e-05)|Renal(207;0.0112)|Lung NSC(271;0.0339)|all_lung(227;0.0616)|all_hematologic(139;0.0748)|Hepatocellular(293;0.137)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.65e-111)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.014)|COAD - Colon adenocarcinoma(134;0.141)|STAD - Stomach adenocarcinoma(1183;0.18)		GATCGCCCATCGATCTCTGTT	0.408000													44	108					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79322950	79322950	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr9:79322950C>T	ENST00000428286.1	-	8	4363	c.3163G>A	c.(3163-3165)Gat>Aat	p.D1055N	PRUNE2_ENST00000376718.3_Missense_Mutation_p.D1414N			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1414					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GTTTGCACATCACGGGAGTCT	0.453000													25	40					0	0	1	0	0
XRCC5	7520	broad.mit.edu	37	2	217057441	217057441	+	Nonsense_Mutation	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:217057441G>A	ENST00000392133.3	+	20	2485	c.2024G>A	c.(2023-2025)tGg>tAg	p.W675*	XRCC5_ENST00000392132.2_Nonsense_Mutation_p.W675*			P13010	XRCC5_HUMAN	X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)	675					double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			endometrium(1)|kidney(3)|large_intestine(8)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		AATCATTTCTGGGAAATTGTT	0.303000								Non-homologous end-joining					23	16					0	0	1	0	0
LAMA4	3910	broad.mit.edu	37	6	112460488	112460488	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr6:112460488T>A	ENST00000230538.7	-	24	3513	c.3116A>T	c.(3115-3117)aAg>aTg	p.K1039M	LAMA4_ENST00000389463.4_Missense_Mutation_p.K1032M|LAMA4_ENST00000424408.2_Missense_Mutation_p.K1032M|LAMA4_ENST00000522006.1_Missense_Mutation_p.K1032M	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	1039					cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		GAAGGCCAGCTTATCTCTGAA	0.458000													5	73					0	0	1	0	0
SEC14L1	6397	broad.mit.edu	37	17	75192298	75192298	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr17:75192298G>T	ENST00000413679.2	+	8	1027	c.724G>T	c.(724-726)Gac>Tac	p.D242Y	SEC14L1_ENST00000585618.1_Missense_Mutation_p.D242Y|SEC14L1_ENST00000431431.2_Missense_Mutation_p.D208Y|SEC14L1_ENST00000392476.2_Missense_Mutation_p.D242Y|SEC14L1_ENST00000591437.1_Missense_Mutation_p.D208Y|SEC14L1_ENST00000430767.4_Missense_Mutation_p.D242Y|SEC14L1_ENST00000436233.4_Missense_Mutation_p.D242Y|SEC14L1_ENST00000443798.4_Missense_Mutation_p.D242Y	NM_001143998.1|NM_001143999.1|NM_003003.3	NP_001137470.1|NP_001137471.1|NP_002994.3	Q92503	S14L1_HUMAN	SEC14-like 1 (S. cerevisiae)	242					transport	Golgi apparatus|integral to membrane	binding			NS(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(2)	31						ACTAGATGCCGACTACATCAA	0.483000													16	50					2.5808e-16	3.66473e-16	1	1	0
RAPH1	65059	broad.mit.edu	37	2	204305324	204305324	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:204305324C>G	ENST00000319170.5	-	14	2888	c.2589G>C	c.(2587-2589)aaG>aaC	p.K863N	RAPH1_ENST00000374493.3_Missense_Mutation_p.K915N|RAPH1_ENST00000457812.1_Intron	NM_213589.1	NP_998754.1	Q70E73	RAPH1_HUMAN	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	863					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				breast(5)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						TGGCTATCTGCTTCACGACCG	0.592000													43	134					0	0	1	0	0
HECTD3	79654	broad.mit.edu	37	1	45472399	45472399	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:45472399C>T	ENST00000372172.4	-	13	1761	c.1690G>A	c.(1690-1692)Gtg>Atg	p.V564M	HECTD3_ENST00000372168.3_Missense_Mutation_p.V174M	NM_024602.5	NP_078878.3	Q5T447	HECD3_HUMAN	HECT domain containing E3 ubiquitin protein ligase 3	564	HECT.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|stomach(1)	28	Acute lymphoblastic leukemia(166;0.155)					GGCAGGGGCACGGGGGTATCC	0.582000													5	61					0	0	1	0	0
TBC1D19	55296	broad.mit.edu	37	4	26719612	26719612	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr4:26719612G>T	ENST00000264866.4	+	14	1290	c.1012G>T	c.(1012-1014)Gcc>Tcc	p.A338S	TBC1D19_ENST00000511789.1_Missense_Mutation_p.A273S	NM_018317.2	NP_060787.2	Q8N5T2	TBC19_HUMAN	TBC1 domain family, member 19	338	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	17		Breast(46;0.0503)				ATTCAACAGTGCCTCGCCACC	0.299000													22	84					0.000375601	0.000393619	1	1	0
ZNF3	7551	broad.mit.edu	37	7	99669594	99669594	+	Silent	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr7:99669594G>A	ENST00000303915.6	-	5	1480	c.513C>T	c.(511-513)agC>agT	p.S171S	ZNF3_ENST00000299667.4_Silent_p.S171S|ZNF3_ENST00000413658.2_Intron|ZNF3_ENST00000424697.1_Silent_p.S171S			P17036	ZNF3_HUMAN	zinc finger protein 3	171					cell differentiation|leukocyte activation|multicellular organismal development	nucleus	DNA binding|identical protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.S171S(1)		NS(1)|breast(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(8)|ovary(1)|skin(2)	25	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)	Ovarian(593;2.06e-05)|Myeloproliferative disorder(862;0.0122)|Breast(660;0.029)	STAD - Stomach adenocarcinoma(171;0.129)			TATATTTCTCGCTTCTCTCTC	0.488000													33	71					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	72956672	72956672	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr12:72956672G>T	ENST00000261180.4	+	9	1855	c.1759G>T	c.(1759-1761)Gta>Tta	p.V587L	TRHDE_ENST00000549138.1_3'UTR	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	587					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						TATACAAGAAGTAATGGATCA	0.299000													50	87					4.21674e-32	7.12829e-32	1	1	0
GADL1	339896	broad.mit.edu	37	3	30875763	30875763	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr3:30875763C>A	ENST00000454381.3	-	10	960	c.914G>T	c.(913-915)gGt>gTt	p.G305V	GADL1_ENST00000282538.5_Missense_Mutation_p.G305V			Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	305					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding			breast(2)|endometrium(3)|kidney(2)|lung(17)|upper_aerodigestive_tract(1)	25					Pyridoxal Phosphate(DB00114)	AGCTGAGCCACCCCAAGAAGC	0.448000													21	39					4.30721e-22	6.72114e-22	1	1	0
USP19	10869	broad.mit.edu	37	3	49148453	49148453	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr3:49148453C>A	ENST00000453664.1	-	23	3757	c.3439G>T	c.(3439-3441)Ggc>Tgc	p.G1147C	USP19_ENST00000398898.2_Missense_Mutation_p.G1096C|USP19_ENST00000434032.2_Missense_Mutation_p.G1157C|USP19_ENST00000417901.1_Missense_Mutation_p.G1159C|USP19_ENST00000398888.2_Missense_Mutation_p.G1056C|USP19_ENST00000398892.3_Missense_Mutation_p.G1096C|USP19_ENST00000398896.1_Missense_Mutation_p.G864C	NM_001199161.1|NM_001199162.1	NP_001186090.1|NP_001186091.1	O94966	UBP19_HUMAN	ubiquitin specific peptidase 19	1056					ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding	p.G1144S(1)		NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GTGAAGTGGCCGGCCCGGGCA	0.617000													26	91					9.86323e-18	1.4439e-17	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141680605	141680605	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:141680605C>A	ENST00000389484.3	-	21	4219	c.3248G>T	c.(3247-3249)aGt>aTt	p.S1083I		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1083	LDL-receptor class A 8.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTTTCATCACTACCATCTTC	0.428000										TSP Lung(27;0.18)			24	83					4.47668e-21	6.79881e-21	1	1	0
BMS1P20	96610	broad.mit.edu	37	22	22664606	22664606	+	RNA	SNP	A	A	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr22:22664606A>G	ENST00000426066.1	+	0	787					NR_027293.1																						GTCTTCATGCAAACTTGGTAT	0.398000													3	25					0	0	1	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47423821	47423821	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr19:47423821G>T	ENST00000404338.3	+	1	1889	c.1889G>T	c.(1888-1890)gGt>gTt	p.G630V		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	630					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										GTGATAGATGGTAAAATGTAT	0.473000													59	103					7.47603e-22	1.16021e-21	1	1	0
ZNF208	7757	broad.mit.edu	37	19	22157592	22157592	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr19:22157592C>A	ENST00000397126.4	-	4	392	c.244G>T	c.(244-246)Gct>Tct	p.A82S	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Missense_Mutation_p.A82S	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				AGATCTTGAGCAAAATGAGAA	0.284000													17	31					2.23348e-06	2.46813e-06	1	1	0
PHF6	84295	broad.mit.edu	37	X	133547667	133547667	+	Nonsense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:133547667G>T	ENST00000332070.3	+	6	767	c.565G>T	c.(565-567)Gaa>Taa	p.E189*	PHF6_ENST00000394292.1_Nonsense_Mutation_p.E190*|PHF6_ENST00000370800.4_Nonsense_Mutation_p.E190*|PHF6_ENST00000370799.1_Nonsense_Mutation_p.E190*|PHF6_ENST00000416404.2_Nonsense_Mutation_p.E155*|PHF6_ENST00000370803.3_Nonsense_Mutation_p.E189*	NM_032458.2	NP_115834.1	Q8IWS0	PHF6_HUMAN	PHD finger protein 6	189					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(88)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(1)|skin(1)|urinary_tract(1)	103	Acute lymphoblastic leukemia(192;0.000127)					TGGAACAGATGAAATGGAAAG	0.338000			"""F, N, Splice, Mis"""		ETP ALL								59	128					1.47633e-17	2.15013e-17	1	1	0
PCNXL3	399909	broad.mit.edu	37	11	65392880	65392880	+	Silent	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr11:65392880C>T	ENST00000355703.3	+	18	3573	c.3034C>T	c.(3034-3036)Ctg>Ttg	p.L1012L		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1012						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CCCCAGGTCTCTGATCCGGAG	0.677000													12	34					0	0	1	0	0
BET1	10282	broad.mit.edu	37	7	93633510	93633510	+	Splice_Site	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr7:93633510C>A	ENST00000222547.3	-	1	177	c.19_splice	c.e1+1	p.G7_splice	AC006378.2_ENST00000426634.1_RNA|BET1_ENST00000433727.1_Splice_Site_p.G7_splice|BET1_ENST00000425626.1_Splice_Site_p.G7_splice	NM_005868.4	NP_005859.1	O15155	BET1_HUMAN	Bet1 golgi vesicular membrane trafficking protein	7					ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	protein binding			large_intestine(2)|lung(1)|prostate(1)|skin(1)	5	all_cancers(62;2.22e-10)|all_epithelial(64;1.38e-09)|Lung NSC(181;0.218)	Breast(660;0.000162)|Ovarian(593;0.000626)	STAD - Stomach adenocarcinoma(171;0.000967)			CTCTTCTTACCCAGGCCTGCA	0.617000													22	67					3.08376e-08	3.74269e-08	1	1	0
JMJD1C	221037	broad.mit.edu	37	10	64973690	64973690	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr10:64973690C>T	ENST00000399262.2	-	8	2455	c.2237G>A	c.(2236-2238)aGa>aAa	p.R746K	JMJD1C_ENST00000402544.1_Missense_Mutation_p.R527K|JMJD1C_ENST00000399251.1_Missense_Mutation_p.R527K|JMJD1C_ENST00000542921.1_Missense_Mutation_p.R564K	NM_032776.1	NP_116165.1	Q15652	JHD2C_HUMAN	jumonji domain containing 1C	746					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(9)|lung(27)|ovary(6)|prostate(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	77	Prostate(12;0.0119)|all_hematologic(501;0.191)					TAAACAGGTTCTATGAGATGA	0.433000													30	71					0	0	1	0	0
PRMT10	90826	broad.mit.edu	37	4	148595012	148595012	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr4:148595012C>A	ENST00000322396.6	-	3	594	c.352G>T	c.(352-354)Gat>Tat	p.D118Y	PRMT10_ENST00000541232.1_Missense_Mutation_p.D5Y	NM_138364.2	NP_612373.2	Q6P2P2	ANM10_HUMAN	protein arginine methyltransferase 10 (putative)	118						cytoplasm	binding|protein methyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28						GCTGCTTCATCCCTAAAGCCC	0.393000													13	51					0.000308642	0.000324646	1	1	0
PTGER4	5734	broad.mit.edu	37	5	40681274	40681274	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr5:40681274G>T	ENST00000302472.3	+	2	1203	c.179G>T	c.(178-180)gGg>gTg	p.G60V	PTGER4_ENST00000514343.1_3'UTR	NM_000958.2	NP_000949.1	P35408	PE2R4_HUMAN	prostaglandin E receptor 4 (subtype EP4)	60					G-protein signaling, coupled to cAMP nucleotide second messenger|immune response	integral to membrane|plasma membrane	prostaglandin E receptor activity			breast(1)|endometrium(3)|liver(1)|lung(13)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23						CTGGTATGTGGGCTGGCTGTC	0.622000											OREG0016588	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	59					1.7881e-09	2.26706e-09	1	1	0
HOXD3	3232	broad.mit.edu	37	2	177034262	177034262	+	Silent	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:177034262C>A	ENST00000468418.3	+	3	2510	c.420C>A	c.(418-420)gcC>gcA	p.A140A	HOXD3_ENST00000410016.1_Silent_p.A140A|HOXD3_ENST00000249440.3_Silent_p.A140A			P31249	HXD3_HUMAN	homeobox D3	140					anterior/posterior pattern formation|cartilage development|cell-matrix adhesion|embryonic skeletal system morphogenesis|Notch signaling pathway|positive regulation of gene expression|positive regulation of neuron differentiation|thyroid gland development		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(11)|prostate(1)|upper_aerodigestive_tract(2)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00569)|Epithelial(96;0.0864)|all cancers(119;0.226)	Colorectal(32;0.247)		GAGTGCCTGCCAAGAAGCCCA	0.587000													37	125					1.08052e-11	1.43396e-11	1	1	0
SPNS3	201305	broad.mit.edu	37	17	4351559	4351559	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr17:4351559G>A	ENST00000355530.2	+	6	1011	c.731G>A	c.(730-732)aGg>aAg	p.R244K	SPNS3_ENST00000333476.2_Missense_Mutation_p.R117K|SPNS3_ENST00000576069.1_3'UTR	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	244					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						GGAGGCTTCAGGAGCAGCTGG	0.622000													12	22					0	0	1	0	0
OR2T33	391195	broad.mit.edu	37	1	248437021	248437021	+	Silent	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:248437021G>T	ENST00000318021.2	-	1	117	c.96C>A	c.(94-96)atC>atA	p.I32I		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AGGTCAAAACGATACTCAGAA	0.478000													30	155					2.24722e-20	3.37678e-20	1	1	0
DMGDH	29958	broad.mit.edu	37	5	78329215	78329215	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr5:78329215C>A	ENST00000255189.3	-	8	1238	c.1210G>T	c.(1210-1212)Gct>Tct	p.A404S	DMGDH_ENST00000540686.1_Missense_Mutation_p.A24S|DMGDH_ENST00000380311.4_Missense_Mutation_p.A203S	NM_013391.2	NP_037523.2	Q9UI17	M2GD_HUMAN	dimethylglycine dehydrogenase	404					choline metabolic process|glycine catabolic process	mitochondrial matrix	aminomethyltransferase activity|dimethylglycine dehydrogenase activity|electron carrier activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	34		all_lung(232;0.000638)|Lung NSC(167;0.00173)|Ovarian(174;0.0262)|Prostate(461;0.192)		OV - Ovarian serous cystadenocarcinoma(54;6.52e-45)|Epithelial(54;5.96e-40)|all cancers(79;3.56e-35)		ACCCCACCAGCGTGGATTATG	0.388000													45	95					1.7489e-18	2.58692e-18	1	1	0
ITGAD	3681	broad.mit.edu	37	16	31409208	31409208	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr16:31409208G>T	ENST00000389202.2	+	5	454	c.405G>T	c.(403-405)caG>caT	p.Q135H		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	135					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						AGATCATCCAGACAGTCCCCG	0.647000													7	21					1.06961e-07	1.26046e-07	1	1	0
KIAA0100	9703	broad.mit.edu	37	17	26969036	26969036	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr17:26969036T>A	ENST00000528896.2	-	7	711	c.637A>T	c.(637-639)Agc>Tgc	p.S213C	KIAA0100_ENST00000544884.1_Missense_Mutation_p.S70C|KIAA0100_ENST00000389003.3_Missense_Mutation_p.S70C	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	213						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					TGCCGACTGCTAATGCCCACC	0.542000													32	53					0	0	1	0	0
SLC6A16	28968	broad.mit.edu	37	19	49796523	49796523	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr19:49796523C>T	ENST00000454748.3	-	10	1936	c.1735G>A	c.(1735-1737)Gta>Ata	p.V579I	SLC6A16_ENST00000335875.4_Missense_Mutation_p.V579I			Q9GZN6	S6A16_HUMAN	solute carrier family 6, member 16	579						integral to membrane|intracellular	neurotransmitter:sodium symporter activity			NS(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		OV - Ovarian serous cystadenocarcinoma(262;0.00099)|GBM - Glioblastoma multiforme(486;0.0336)		GTTTCAAATACGACAACGACG	0.532000													15	45					0	0	1	0	0
TSPYL6	388951	broad.mit.edu	37	2	54482311	54482311	+	Silent	SNP	A	A	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:54482311A>C	ENST00000317802.7	-	1	1098	c.978T>G	c.(976-978)acT>acG	p.T326T	ACYP2_ENST00000606865.1_Intron|ACYP2_ENST00000394666.3_Intron|ACYP2_ENST00000303536.4_Intron|ACYP2_ENST00000607452.1_Intron	NM_001003937.2	NP_001003937.2	Q8N831	TSYL6_HUMAN	TSPY-like 6	326					nucleosome assembly	nucleus				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(1)|ovary(1)|skin(1)|stomach(2)	20						ACATGATTAGAGTGGAAAAAG	0.468000													7	121					0	0	1	0	0
AAR2	25980	broad.mit.edu	37	20	34832682	34832682	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr20:34832682G>T	ENST00000373932.3	+	3	1167	c.821G>T	c.(820-822)tGg>tTg	p.W274L	AAR2_ENST00000397286.3_Missense_Mutation_p.W274L|AAR2_ENST00000320849.4_Missense_Mutation_p.W274L	NM_015511.3	NP_056326.2			AAR2 splicing factor homolog (S. cerevisiae)																		TTTGAGCATTGGAAGCGGCTC	0.527000													23	68					2.27731e-05	2.46853e-05	1	1	0
GFPT1	2673	broad.mit.edu	37	2	69565089	69565089	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:69565089C>T	ENST00000357308.4	-	15	1601	c.1423G>A	c.(1423-1425)Gag>Aag	p.E475K	GFPT1_ENST00000361060.4_Missense_Mutation_p.E457K	NM_001244710.1	NP_001231639.1	Q06210	GFPT1_HUMAN	glutamine--fructose-6-phosphate transaminase 1	475	SIS 1.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			endometrium(1)|large_intestine(3)|lung(5)|skin(3)	12						CAATCTGTCTCCCGTGATATG	0.418000													69	215					0	0	1	0	0
TOP2A	7153	broad.mit.edu	37	17	38567973	38567973	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr17:38567973C>T	ENST00000423485.1	-	8	1045	c.887G>A	c.(886-888)aGg>aAg	p.R296K		NM_001067.3	NP_001058.2	P11388	TOP2A_HUMAN	topoisomerase (DNA) II alpha 170kDa	296					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(9)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	39		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	CACTTCCCACCTGTGGTTTAC	0.343000													16	14					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48242388	48242388	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr16:48242388C>A	ENST00000394747.1	-	11	1977	c.1628G>T	c.(1627-1629)tGc>tTc	p.C543F	ABCC11_ENST00000353782.5_Missense_Mutation_p.C543F|ABCC11_ENST00000356608.2_Missense_Mutation_p.C543F|ABCC11_ENST00000394748.1_Missense_Mutation_p.C543F|ABCC11_ENST00000537808.1_Missense_Mutation_p.C543F	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	543	ABC transporter 1.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				CGTGTTGCCGCAGACCCCTAA	0.577000													27	47					1.75199e-13	2.40369e-13	1	1	0
ZCCHC11	23318	broad.mit.edu	37	1	52943553	52943553	+	Splice_Site	SNP	G	G	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:52943553G>C	ENST00000371544.3	-	12	2112	c.1848_splice	c.e12-1	p.S617_splice	ZCCHC11_ENST00000257177.4_Splice_Site_p.S617_splice|ZCCHC11_ENST00000371541.1_5'UTR	NM_001009881.2|NM_015269.2	NP_001009881.1|NP_056084.1	Q5TAX3	TUT4_HUMAN	zinc finger, CCHC domain containing 11	617					miRNA catabolic process|pre-miRNA processing|RNA 3'-end processing|stem cell maintenance	cytoplasm|nucleolus	nucleic acid binding|protein binding|RNA uridylyltransferase activity|zinc ion binding			NS(2)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(17)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	58						TGCTAAAGGAGACTGGAAAAG	0.348000													16	41					0	0	1	0	0
RAB11FIP3	9727	broad.mit.edu	37	16	511444	511444	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr16:511444G>T	ENST00000262305.4	+	2	1143	c.755G>T	c.(754-756)gGc>gTc	p.G252V	RAB11FIP3_ENST00000457159.1_Missense_Mutation_p.G252V	NM_014700.3	NP_055515.1	O75154	RFIP3_HUMAN	RAB11 family interacting protein 3 (class II)	252	EF-hand 2.				cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding	p.G252V(1)		breast(1)|endometrium(2)|kidney(3)|lung(5)|upper_aerodigestive_tract(1)	12		Hepatocellular(16;0.0218)				AGTGGGCTCGGCGTGATCAGC	0.532000													39	94					9.39024e-22	1.44936e-21	1	1	0
ADAMTS2	9509	broad.mit.edu	37	5	178585795	178585795	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr5:178585795G>T	ENST00000251582.7	-	6	1162	c.1061C>A	c.(1060-1062)aCg>aAg	p.T354K	ADAMTS2_ENST00000274609.5_Missense_Mutation_p.T354K	NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	354	Peptidase M12B.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		ATCGTGGCCCGTGTCTGGCTT	0.612000													31	77					8.16721e-17	1.16557e-16	1	1	0
MIR325	442899	broad.mit.edu	37	X	76225865	76225865	+	RNA	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:76225865C>A	ENST00000385260.1	-	0	61					NR_029905.1																						ataggaggtcctcaataaaca	0.398000													23	72					1.10513e-12	1.48046e-12	1	1	0
POP7	10248	broad.mit.edu	37	7	100304745	100304745	+	Missense_Mutation	SNP	G	G	A	rs145447976	byFrequency	TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr7:100304745G>A	ENST00000303151.4	+	2	554	c.292G>A	c.(292-294)Gtg>Atg	p.V98M		NM_005837.2	NP_005828.2	O75817	POP7_HUMAN	processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae)	98					tRNA processing	nucleolar ribonuclease P complex	protein binding|ribonuclease P activity			endometrium(2)|kidney(1)|ovary(1)	4	Lung NSC(181;0.041)|all_lung(186;0.0581)					GTCCTTGCAGGTGGCTGCCAA	0.617000													8	110					0	0	1	0	0
CYP2D7	1564	broad.mit.edu	37	22	42536349	42536349	+	RNA	SNP	A	A	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr22:42536349A>G	ENST00000435101.1	-	0	556				CYP2D7P1_ENST00000433992.1_RNA|CYP2D7P1_ENST00000358097.4_RNA																endometrium(1)	1						TGACGACACGAGAGTGGCTGG	0.652000													3	14					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30585239	30585239	+	Silent	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr20:30585239G>T	ENST00000217299.3	+	3	1893	c.1719G>T	c.(1717-1719)ctG>ctT	p.L573L		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	573						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			AGGAGCTGCTGGAGTATGAGA	0.612000													12	27					0.000978159	0.00101757	1	1	0
PCDHB14	56122	broad.mit.edu	37	5	140603170	140603170	+	Silent	SNP	A	A	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr5:140603170A>G	ENST00000239449.4	+	1	93	c.93A>G	c.(91-93)gcA>gcG	p.A31A	PCDHB14_ENST00000515856.2_Intron	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		31					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTGAATCTGCACACTATTCTG	0.507000													16	35					0	0	1	0	0
LRTM2	654429	broad.mit.edu	37	12	1943618	1943618	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr12:1943618G>T	ENST00000543818.1	+	5	1686	c.844G>T	c.(844-846)Ggg>Tgg	p.G282W	CACNA2D4_ENST00000586184.1_Intron|LRTM2_ENST00000543730.1_3'UTR|LRTM2_ENST00000535041.1_Missense_Mutation_p.G282W|LRTM2_ENST00000299194.1_Missense_Mutation_p.G282W|CACNA2D4_ENST00000588077.1_Intron|CACNA2D4_ENST00000382722.5_Intron|CACNA2D4_ENST00000587995.1_Intron|CACNA2D4_ENST00000585708.1_Intron|CACNA2D4_ENST00000585732.1_Intron	NM_001039029.2|NM_001163925.1|NM_001163926.1	NP_001034118.1|NP_001157397.1|NP_001157398.1	Q8N967	LRTM2_HUMAN	leucine-rich repeats and transmembrane domains 2	282						integral to membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	20	Ovarian(42;0.107)		OV - Ovarian serous cystadenocarcinoma(31;0.000834)			GCCCAAGCCCGGGGCTGAGCC	0.667000													12	38					2.27111e-07	2.63263e-07	1	1	0
KEAP1	9817	broad.mit.edu	37	19	10602923	10602923	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr19:10602923C>G	ENST00000171111.5	-	3	1202	c.655G>C	c.(655-657)Gag>Cag	p.E219Q	KEAP1_ENST00000393623.2_Missense_Mutation_p.E219Q|KEAP1_ENST00000588024.1_5'UTR	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	219	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			TTGAAGAACTCCTCTTGCTTG	0.602000													17	28					0	0	1	0	0
CS	1431	broad.mit.edu	37	12	56667541	56667541	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr12:56667541C>G	ENST00000548567.1	-	11	1332	c.862G>C	c.(862-864)Gat>Cat	p.D288H	CS_ENST00000351328.3_Missense_Mutation_p.D354H|CS_ENST00000542324.2_Missense_Mutation_p.D341H			O75390	CISY_HUMAN	citrate synthase	354					cellular carbohydrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix	citrate (Si)-synthase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(4)|ovary(1)|skin(1)	17		Myeloproliferative disorder(1001;0.000374)		BRCA - Breast invasive adenocarcinoma(357;6.17e-07)		TATCGCGGATCAGTCTTCCTT	0.423000													19	78					0	0	1	0	0
DPP10	57628	broad.mit.edu	37	2	116539951	116539951	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:116539951C>A	ENST00000410059.1	+	17	1987	c.1507C>A	c.(1507-1509)Cta>Ata	p.L503I	DPP10_ENST00000409163.1_Missense_Mutation_p.L453I|DPP10_ENST00000310323.8_Missense_Mutation_p.L496I|DPP10_ENST00000393147.2_Missense_Mutation_p.L507I	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	503					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						AGTGGTCAGCCTACATAGTAC	0.338000													38	56					9.62906e-15	1.34712e-14	1	1	0
DSG1	1828	broad.mit.edu	37	18	28919895	28919895	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr18:28919895C>A	ENST00000257192.4	+	11	1806	c.1594C>A	c.(1594-1596)Ccc>Acc	p.P532T		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	532					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			TTCTTCTGAACCCGGAAACGG	0.403000													47	75					5.78141e-17	8.37715e-17	1	1	0
NLGN4X	57502	broad.mit.edu	37	X	5827217	5827217	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:5827217G>T	ENST00000381095.3	-	4	1316	c.689C>A	c.(688-690)gCa>gAa	p.A230E	NLGN4X_ENST00000538097.1_Missense_Mutation_p.A230E|NLGN4X_ENST00000275857.6_Missense_Mutation_p.A230E|NLGN4X_ENST00000381092.1_Missense_Mutation_p.A230E|NLGN4X_ENST00000381093.2_Missense_Mutation_p.A250E	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	230					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						CCACCGCAGTGCTTGAATCTG	0.527000													21	46					5.35356e-11	7.0065e-11	1	1	0
MAP7D1	55700	broad.mit.edu	37	1	36643587	36643587	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:36643587G>A	ENST00000316156.4	+	8	1835	c.1382G>A	c.(1381-1383)cGa>cAa	p.R461Q	MAP7D1_ENST00000373151.2_Missense_Mutation_p.R498Q|MAP7D1_ENST00000373150.4_Missense_Mutation_p.R466Q|MAP7D1_ENST00000373148.4_Missense_Mutation_p.R44Q			Q3KQU3	MA7D1_HUMAN	MAP7 domain containing 1	498						cytoplasm|spindle				breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	19		Myeloproliferative disorder(586;0.0393)				CCGTCCCCCCGAGGCACCACT	0.706000													10	32					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146536993	146536993	+	Silent	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr7:146536993C>T	ENST00000361727.3	+	3	915	c.399C>T	c.(397-399)atC>atT	p.I133I		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	133	F5/8 type C.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ATGGGAATATCTGGGTAAGTC	0.403000										HNSCC(39;0.1)			20	29					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37508171	37508171	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr10:37508171G>T	ENST00000374660.1	+	40	3819	c.3720G>T	c.(3718-3720)atG>atT	p.M1240I	ANKRD30A_ENST00000361713.1_Missense_Mutation_p.M1121I|ANKRD30A_ENST00000602533.1_Missense_Mutation_p.M1121I			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	1177						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AGAACACAATGCTCACTTCTA	0.388000													12	161					2.27111e-07	2.63263e-07	1	1	0
EPHA5	2044	broad.mit.edu	37	4	66286268	66286268	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr4:66286268G>T	ENST00000273854.3	-	6	2018	c.1418C>A	c.(1417-1419)aCc>aAc	p.T473N	EPHA5_ENST00000354839.4_Missense_Mutation_p.T473N|EPHA5_ENST00000432638.2_Missense_Mutation_p.T309N|EPHA5_ENST00000511294.1_Missense_Mutation_p.T473N	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	473	Fibronectin type-III 2.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity	p.T473I(1)		autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						TTTCACATTGGTGACTGGAGA	0.353000										TSP Lung(17;0.13)			13	30					7.03913e-09	8.76803e-09	1	1	0
SPATA31E1	286234	broad.mit.edu	37	9	90500444	90500444	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr9:90500444C>A	ENST00000325643.5	+	4	1108	c.1042C>A	c.(1042-1044)Cac>Aac	p.H348N		NM_178828.4	NP_849150.3			SPATA31 subfamily E, member 1																		CACACCCAAGCACATGGAGGT	0.587000													19	41					5.3912e-06	5.91159e-06	1	1	0
GPR98	84059	broad.mit.edu	37	5	90079695	90079695	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr5:90079695A>G	ENST00000405460.2	+	67	13570	c.13474A>G	c.(13474-13476)Act>Gct	p.T4492A	GPR98_ENST00000425867.2_Missense_Mutation_p.T153A	NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4492					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CACTGGAGCTACTGGAGGAGC	0.428000													4	15					0	0	1	0	0
ADCY9	115	broad.mit.edu	37	16	4016478	4016478	+	Silent	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr16:4016478C>T	ENST00000294016.3	-	11	3898	c.3360G>A	c.(3358-3360)ctG>ctA	p.L1120L		NM_001116.3	NP_001107.2	O60503	ADCY9_HUMAN	adenylate cyclase 9	1120	Guanylate cyclase 2.				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						GCGCGGTGTTCAGCCCTGACG	0.607000													44	70					0	0	1	0	0
ATP7B	540	broad.mit.edu	37	13	52532665	52532665	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr13:52532665A>G	ENST00000242839.4	-	8	2293	c.2137T>C	c.(2137-2139)Tac>Cac	p.Y713H	ATP7B_ENST00000400366.3_Missense_Mutation_p.Y602H|ATP7B_ENST00000417240.2_5'UTR|ATP7B_ENST00000344297.5_Intron|ATP7B_ENST00000400370.3_Intron|ATP7B_ENST00000448424.2_Intron|ATP7B_ENST00000542656.1_Missense_Mutation_p.V488A|ATP7B_ENST00000418097.2_Missense_Mutation_p.Y713H|ATP7B_ENST00000482841.1_Intron	NM_000053.3	NP_000044.2	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	713			Y -> C (in WD).		ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(23)|ovary(1)|prostate(3)|skin(4)|stomach(2)	55		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		ACGTAGAAGTACCACCCACCG	0.542000									Wilson disease				19	50					0	0	1	0	0
COPB1	1315	broad.mit.edu	37	11	14479388	14479388	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr11:14479388C>A	ENST00000249923.3	-	22	3144	c.2844G>T	c.(2842-2844)caG>caT	p.Q948H	COPB1_ENST00000439561.2_Missense_Mutation_p.Q948H	NM_016451.4	NP_057535.1	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1	948					COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	36						TAGTTTTCTTCTGTGACAAGT	0.289000													18	24					4.75885e-15	6.69066e-15	1	1	0
PDE11A	50940	broad.mit.edu	37	2	178494216	178494216	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:178494216C>G	ENST00000286063.5	-	20	3038	c.2721G>C	c.(2719-2721)gaG>gaC	p.E907D	PDE11A_ENST00000358450.4_Missense_Mutation_p.E657D|PDE11A_ENST00000450799.2_Missense_Mutation_p.E98D|PDE11A_ENST00000449286.2_Missense_Mutation_p.E549D|PDE11A_ENST00000409504.1_Missense_Mutation_p.E549D|PDE11A_ENST00000389683.3_Missense_Mutation_p.E463D	NM_016953.3	NP_058649.3	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A	907					platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TTTGGTGTAGCTCTTCCCACT	0.478000									Primary Pigmented Nodular Adrenocortical Disease, Familial				88	120					0	0	1	0	0
GPR128	84873	broad.mit.edu	37	3	100364873	100364873	+	Missense_Mutation	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr3:100364873G>A	ENST00000273352.3	+	9	1299	c.1031G>A	c.(1030-1032)aGt>aAt	p.S344N	GPR128_ENST00000475887.1_Missense_Mutation_p.S49N	NM_032787.2	NP_116176.2	Q96K78	GP128_HUMAN	G protein-coupled receptor 128	344					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	56						TCGGATTTTAGTCAAAAAATT	0.348000													18	42					0	0	1	0	0
COMMD4	54939	broad.mit.edu	37	15	75632117	75632117	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr15:75632117C>T	ENST00000267935.8	+	7	656	c.457C>T	c.(457-459)Ccc>Tcc	p.P153S	COMMD4_ENST00000567195.1_Intron|COMMD4_ENST00000564815.1_Missense_Mutation_p.P131S|COMMD4_ENST00000562789.1_Intron|COMMD4_ENST00000338995.6_Intron	NM_017828.3	NP_060298.2	Q9H0A8	COMD4_HUMAN	COMM domain containing 4	153	COMM.					cytoplasm	protein binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(1)|lung(1)|prostate(1)	10						CGTGGAAGAGCCCATGGTGCA	0.642000													11	17					0	0	1	0	0
MS4A4E	643680	broad.mit.edu	37	11	59992493	59992493	+	Missense_Mutation	SNP	T	T	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr11:59992493T>A	ENST00000427611.2	-	4	398	c.179A>T	c.(178-180)tAt>tTt	p.Y60F	MS4A4E_ENST00000398984.2_Missense_Mutation_p.Y73F|MS4A4E_ENST00000398986.2_Intron|MS4A4E_ENST00000526086.1_Intron|MS4A4E_ENST00000425663.1_Intron|MS4A4E_ENST00000528394.1_Missense_Mutation_p.Y73F					membrane-spanning 4-domains, subfamily A, member 4E											ovary(1)	1						ATGTTCTTCATAAGAACTAAA	0.358000													3	11					0	0	1	0	0
SFI1	9814	broad.mit.edu	37	22	31998707	31998707	+	Missense_Mutation	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr22:31998707C>T	ENST00000432498.1	+	16	2041	c.1648C>T	c.(1648-1650)Cgc>Tgc	p.R550C	SFI1_ENST00000443326.1_Missense_Mutation_p.R499C|SFI1_ENST00000443011.1_Missense_Mutation_p.R428C|SFI1_ENST00000400289.1_Missense_Mutation_p.R499C|SFI1_ENST00000414585.1_Missense_Mutation_p.R428C|SFI1_ENST00000400288.2_Missense_Mutation_p.R581C|SFI1_ENST00000540643.1_Missense_Mutation_p.R526C	NM_014775.3	NP_055590.2	A8K8P3	SFI1_HUMAN	Sfi1 homolog, spindle assembly associated (yeast)	581					G2/M transition of mitotic cell cycle	centriole|cytosol				NS(2)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)	38						TGCCCACCACCGCCACGGGCG	0.582000													4	44					0	0	1	0	0
DAOA-AS1	282706	broad.mit.edu	37	13	106118505	106118505	+	RNA	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr13:106118505C>A	ENST00000448407.1	-	0	739					NR_040247.1																						agagctacaccccaaattagt	0.423000													3	11					1	1	1	1	0
BTNL3	10917	broad.mit.edu	37	5	180432766	180432766	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr5:180432766T>C	ENST00000342868.6	+	8	1479	c.1295T>C	c.(1294-1296)cTg>cCg	p.L432P		NM_197975.2	NP_932079.1	Q6UXE8	BTNL3_HUMAN	butyrophilin-like 3	432	B30.2/SPRY.				lipid metabolic process	integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(1)|lung(10)|prostate(2)|skin(1)	25	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.00336)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)|all_lung(500;0.248)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000272)			ATTTATACCCTGCTGACATGT	0.502000													15	46					0	0	1	0	0
SIMC1	375484	broad.mit.edu	37	5	175716824	175716824	+	Silent	SNP	A	A	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr5:175716824A>T	ENST00000443967.1	+	4	647	c.240A>T	c.(238-240)acA>acT	p.T80T	SIMC1_ENST00000430704.2_Intron|SIMC1_ENST00000503595.1_3'UTR|SIMC1_ENST00000341199.6_Intron|SIMC1_ENST00000429602.2_Silent_p.T99T					SUMO-interacting motifs containing 1																		GTCTTCAGACATGTGCCAGCC	0.498000													16	51					0	0	1	0	0
FBXO30	84085	broad.mit.edu	37	6	146125711	146125711	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr6:146125711C>A	ENST00000237281.4	-	2	1997	c.1831G>T	c.(1831-1833)Gac>Tac	p.D611Y		NM_032145.4	NP_115521.3	Q8TB52	FBX30_HUMAN	F-box protein 30	611							ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		CTTAGATGGTCATTATGTAAT	0.428000													23	38					1.22574e-08	1.50697e-08	1	1	0
OR6C3	254786	broad.mit.edu	37	12	55725574	55725574	+	Silent	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr12:55725574C>T	ENST00000379667.1	+	1	90	c.90C>T	c.(88-90)atC>atT	p.I30I		NM_054104.1	NP_473445.1	Q9NZP0	OR6C3_HUMAN	olfactory receptor, family 6, subfamily C, member 3	30					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|prostate(1)|skin(2)	11						TTTTATTTATCACGTATATAT	0.418000													41	98					0	0	1	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47422924	47422924	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr19:47422924A>T	ENST00000404338.3	+	1	992	c.992A>T	c.(991-993)gAg>gTg	p.E331V		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	331					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										CTCAAGCATGAGCATATCGAG	0.478000													14	26					0	0	1	0	0
EPHA5	2044	broad.mit.edu	37	4	66286274	66286274	+	Missense_Mutation	SNP	G	G	T	rs143584300		TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr4:66286274G>T	ENST00000273854.3	-	6	2012	c.1412C>A	c.(1411-1413)cCa>cAa	p.P471Q	EPHA5_ENST00000354839.4_Missense_Mutation_p.P471Q|EPHA5_ENST00000432638.2_Missense_Mutation_p.P307Q|EPHA5_ENST00000511294.1_Missense_Mutation_p.P471Q	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	471	Fibronectin type-III 2.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						ATTGGTGACTGGAGATGGAGC	0.358000										TSP Lung(17;0.13)			12	32					5.16669e-11	6.79324e-11	1	1	0
LRRC7	57554	broad.mit.edu	37	1	70541787	70541787	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:70541787G>T	ENST00000310961.5	+	24	4436	c.4018G>T	c.(4018-4020)Ggg>Tgg	p.G1340W	LRRC7_ENST00000035383.5_Missense_Mutation_p.G1382W|LRRC7_ENST00000415775.2_Missense_Mutation_p.G666W			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1382						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						GACGTTGATGGGGTCCCAAAG	0.478000													17	55					4.7546e-09	5.94849e-09	1	1	0
PRAMEF10	343071	broad.mit.edu	37	1	12954997	12954997	+	Splice_Site	SNP	T	T	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:12954997T>A	ENST00000235347.4	-	3	367		c.e3-2			NM_001039361.3	NP_001034450.2	O60809	PRA10_HUMAN	PRAME family member 10											NS(2)|breast(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TTCCACCTCCTGTGAGTAACA	0.532000													83	99					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103540337	103540337	+	Splice_Site	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:103540337C>G	ENST00000358392.2	-	4	806		c.e4-1		COL11A1_ENST00000512756.1_Splice_Site|COL11A1_ENST00000370096.3_Splice_Site|COL11A1_ENST00000353414.4_Splice_Site	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1						collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CCGATGCCACCTAAAAAAGAC	0.353000													15	40					0	0	1	0	0
PSMA3-AS1	379025	broad.mit.edu	37	14	58752320	58752320	+	RNA	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr14:58752320C>A	ENST00000554360.1	-	0	402				RP11-349A22.5_ENST00000557412.1_RNA|RP11-349A22.5_ENST00000557660.1_RNA|RP11-349A22.5_ENST00000556400.1_RNA|RP11-349A22.5_ENST00000553657.1_RNA|RP11-349A22.5_ENST00000556002.1_RNA|RP11-349A22.5_ENST00000554378.1_RNA|RP11-349A22.5_ENST00000555275.1_RNA|RP11-349A22.5_ENST00000555707.1_RNA	NR_029434.1																						TTGCCTGGTACAGTATGGGGG	0.388000													3	2					6.4e-05	6.88485e-05	1	1	0
CCDC88A	55704	broad.mit.edu	37	2	55646154	55646154	+	Splice_Site	SNP	C	C	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr2:55646154C>T	ENST00000436346.1	-	1	903	c.63_splice	c.e1+1	p.W21_splice	CCDC88A_ENST00000336838.6_Splice_Site_p.W21_splice|CCDC88A_ENST00000413716.2_Splice_Site_p.W21_splice|CCDC88A_ENST00000471947.1_5'UTR|CCDC88A_ENST00000263630.8_Splice_Site_p.W21_splice	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	21					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						CCCACTTACCCAAGTGACCAA	0.423000													15	78					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417320	150417320	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr7:150417320C>G	ENST00000307194.5	+	3	368	c.228C>G	c.(226-228)tgC>tgG	p.C76W		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGGACAAGTGCCACGTGGAAG	0.627000													29	55					0	0	1	0	0
GPR26	2849	broad.mit.edu	37	10	125426361	125426361	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr10:125426361G>T	ENST00000284674.1	+	1	491	c.438G>T	c.(436-438)tgG>tgT	p.W146C		NM_153442.3	NP_703143.1	Q8NDV2	GPR26_HUMAN	G protein-coupled receptor 26	146					activation of adenylate cyclase activity by G-protein signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(2)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	20		Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)				CCCTGTCCTGGCTCGGCTTCC	0.711000													9	15					0.00448238	0.00457912	1	1	0
PDE4DIP	9659	broad.mit.edu	37	1	144868093	144868093	+	Silent	SNP	G	G	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:144868093G>A	ENST00000369359.4	-	36	5792	c.5754C>T	c.(5752-5754)aaC>aaT	p.N1918N	PDE4DIP_ENST00000313382.9_Silent_p.N1676N|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000530740.1_Silent_p.N1867N|PDE4DIP_ENST00000369356.4_Silent_p.N1782N|PDE4DIP_ENST00000369354.3_Silent_p.N1782N			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1782					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GCTGGGCAGAGTTGAGGTAGT	0.552000			T	PDGFRB	MPD								43	191					0	0	1	0	0
PPP1R10	5514	broad.mit.edu	37	6	30571007	30571007	+	Missense_Mutation	SNP	T	T	C			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr6:30571007T>C	ENST00000376511.2	-	17	2375	c.1823A>G	c.(1822-1824)gAc>gGc	p.D608G		NM_002714.3	NP_002705.2	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	608	Gly-rich.|Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(3)|skin(1)	25						CTTGATCTTGTCCGAATAGTC	0.517000													31	89					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79321279	79321279	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr9:79321279C>A	ENST00000428286.1	-	8	6034	c.4834G>T	c.(4834-4836)Gac>Tac	p.D1612Y	PRUNE2_ENST00000376718.3_Missense_Mutation_p.D1971Y			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	1971					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						AAGGCTGTGTCCGGATGATCA	0.443000													34	74					1.56442e-22	2.4683e-22	1	1	0
ASXL3	80816	broad.mit.edu	37	18	31319913	31319913	+	Missense_Mutation	SNP	C	C	A			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr18:31319913C>A	ENST00000269197.5	+	11	2545	c.2545C>A	c.(2545-2547)Cct>Act	p.P849T		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	849					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding	p.P849T(1)|p.P556T(1)		breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						GAAGCCCTACCCTGCTTCAAT	0.398000													13	28					4.36969e-10	5.64087e-10	1	1	0
CHST7	56548	broad.mit.edu	37	X	46433844	46433844	+	Missense_Mutation	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chrX:46433844C>G	ENST00000276055.3	+	1	626	c.478C>G	c.(478-480)Ctc>Gtc	p.L160V		NM_019886.2	NP_063939.2	Q9NS84	CHST7_HUMAN	carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7	160					chondroitin sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	chondroitin 6-sulfotransferase activity|N-acetylglucosamine 6-O-sulfotransferase activity			breast(3)|endometrium(2)|kidney(1)|lung(2)	8						GCTGCGTTCGCTCTTCCGCTG	0.677000													20	34					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35873695	35873695	+	Missense_Mutation	SNP	G	G	T	rs104893893		TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr5:35873695G>T	ENST00000303115.3	+	5	780	c.651G>T	c.(649-651)tgG>tgT	p.W217C	IL7R_ENST00000343305.4_Missense_Mutation_p.W217C|IL7R_ENST00000506850.1_Missense_Mutation_p.W217C	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	217	Fibronectin type-III.				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			AAGGCTTCTGGAGTGAATGGA	0.438000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						13	65					2.27111e-07	2.63263e-07	1	1	0
ARID3A	1820	broad.mit.edu	37	19	968450	968450	+	Missense_Mutation	SNP	A	A	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr19:968450A>T	ENST00000263620.3	+	8	1868	c.1541A>T	c.(1540-1542)aAc>aTc	p.N514I		NM_005224.2	NP_005215.1	Q99856	ARI3A_HUMAN	AT rich interactive domain 3A (BRIGHT-like)	514	REKLES.					cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(1)	10		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGGGCACCAACGGCAGCAAC	0.542000													16	43					0	0	1	0	0
EOMES	8320	broad.mit.edu	37	3	27758884	27758884	+	Missense_Mutation	SNP	A	A	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr3:27758884A>G	ENST00000295743.4	-	6	1941	c.1738T>C	c.(1738-1740)Tct>Cct	p.S580P	EOMES_ENST00000537516.1_Missense_Mutation_p.S304P|EOMES_ENST00000449599.1_Missense_Mutation_p.S599P			O95936	EOMES_HUMAN	eomesodermin	580	Required for transcription activation (By similarity).				CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(1)	21						CTCTGGTAAGAACCTCGACCT	0.532000													16	53					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65393131	65393131	+	Silent	SNP	C	C	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr11:65393131C>G	ENST00000355703.3	+	19	3683	c.3144C>G	c.(3142-3144)gtC>gtG	p.V1048V		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1048						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						AGCGTGAGGTCTTGCACTCCG	0.622000													7	30					0	0	1	0	0
AAR2	25980	broad.mit.edu	37	20	34832683	34832683	+	Missense_Mutation	SNP	G	G	T			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr20:34832683G>T	ENST00000373932.3	+	3	1168	c.822G>T	c.(820-822)tgG>tgT	p.W274C	AAR2_ENST00000397286.3_Missense_Mutation_p.W274C|AAR2_ENST00000320849.4_Missense_Mutation_p.W274C	NM_015511.3	NP_056326.2			AAR2 splicing factor homolog (S. cerevisiae)																		TTGAGCATTGGAAGCGGCTCC	0.527000													22	68					1.64113e-05	1.78576e-05	1	1	0
MTOR	2475	broad.mit.edu	37	1	11317216	11317217	+	Frame_Shift_Ins	INS	-	-	G			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:11317216_11317217insG	ENST00000361445.4	-	4	353_354	c.277_278insC	c.(277-279)catfs	p.H93fs		NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	93					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						CACTCCTATGAGGCTAGCTGCA	0.530													7	14	---	---	---	---					
TNN	63923	broad.mit.edu	37	1	175116086	175116086	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr1:175116086delG	ENST00000239462.4	+	19	3892	c.3779delG	c.(3778-3780)tgfs	p.W1260fs		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	1260	Fibrinogen C-terminal.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TGGGAGCCTTGGAAAGGACAT	0.493											OREG0013992	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	63	---	---	---	---					
PCDHGB1	56104	broad.mit.edu	37	5	140731390	140731391	+	Frame_Shift_Del	DEL	GC	GC	-			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr5:140731390_140731391delGC	ENST00000523390.1	+	1	1563_1564	c.1563_1564delGC	c.(1561-1566)ctgcfs	p.LR521fs	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_018922.2|NM_032095.1	NP_061745.1|NP_115266.1														central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGAGCAGCTGCGCGCCTTCGA	0.688													36	68	---	---	---	---					
PMS2CL	441194	broad.mit.edu	37	7	6774808	6774809	+	RNA	INS	-	-	A	rs79351634		TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr7:6774808_6774809insA	ENST00000486256.1	+	0	748					NR_002217.1																						gaccttgtctcaaaaaaaaaac	0.470													3	4	---	---	---	---					
MARK2	2011	broad.mit.edu	37	11	63668343	63668343	+	Frame_Shift_Del	DEL	G	G	-			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr11:63668343delG	ENST00000402010.2	+	10	1559	c.980delG	c.(979-981)cgfs	p.R328fs	MARK2_ENST00000350490.7_Frame_Shift_Del_p.R328fs|MARK2_ENST00000377809.4_Frame_Shift_Del_p.R328fs|MARK2_ENST00000425897.2_Frame_Shift_Del_p.R295fs|MARK2_ENST00000502399.3_Frame_Shift_Del_p.R328fs|MARK2_ENST00000513765.2_Frame_Shift_Del_p.R295fs|MARK2_ENST00000509502.2_Frame_Shift_Del_p.R295fs|MARK2_ENST00000377810.3_Frame_Shift_Del_p.R295fs|MARK2_ENST00000361128.5_Frame_Shift_Del_p.R328fs|MARK2_ENST00000408948.3_Frame_Shift_Del_p.R295fs|MARK2_ENST00000315032.8_Frame_Shift_Del_p.R328fs|MARK2_ENST00000508192.1_Frame_Shift_Del_p.R328fs|MARK2_ENST00000413835.2_Frame_Shift_Del_p.R328fs	NM_001039469.2	NP_001034558.2	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	328	UBA.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity	p.R294Q(1)		autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33						AAGGACCCCCGGCGGACAGGT	0.547													58	108	---	---	---	---					
ADAMTS20	80070	broad.mit.edu	37	12	43771174	43771175	+	Frame_Shift_Del	DEL	CC	CC	-			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr12:43771174_43771175delCC	ENST00000389420.3	-	32	4987_4988	c.4988_4989delGG	c.(4987-4989)tfs	p.W1663fs		NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	1663	TSP type-1 15.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CGACCTTGCTCCATTTTCCAAC	0.401													11	18	---	---	---	---					
STK11	6794	broad.mit.edu	37	19	1207092	1207092	+	Frame_Shift_Del	DEL	C	C	-			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr19:1207092delC	ENST00000326873.7	+	1	1353	c.180delC	c.(178-180)tafs	p.Y60fs	STK11_ENST00000585748.1_Intron	NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	60	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(3)|p.Y60fs*1(3)|p.Y60*(2)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGGCTCTTACGGCAAGGTGA	0.622		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			27	18	---	---	---	---					
RP13-329D4.3	0	broad.mit.edu	37	20	26113543	26113543	+	RNA	DEL	A	A	-			TCGA-97-A4M3-01A-11D-A24P-08	TCGA-97-A4M3-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	88680b50-91b8-43f4-a7a8-5685713761d9	6e24551c-babf-4b33-b862-2d96666d96d8	g.chr20:26113543delA	ENST00000416563.1	-	0	250																											TCTTTGCCTTAACAACATTAT	0.363													4	7	---	---	---	---					
