Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC6A2	6530	broad.mit.edu	37	16	55719143	55719143	+	Missense_Mutation	SNP	G	G	T	rs1805066	byFrequency	TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:55719143G>T	ENST00000379906.2	+	4	988	c.733G>T	c.(733-735)Gtc>Ttc	p.V245F	SLC6A2_ENST00000567238.1_Missense_Mutation_p.V140F|SLC6A2_ENST00000219833.8_Missense_Mutation_p.V245F|SLC6A2_ENST00000566163.1_Missense_Mutation_p.V245F|SLC6A2_ENST00000568943.1_Missense_Mutation_p.V245F|SLC6A2_ENST00000561820.1_Missense_Mutation_p.V245F|SLC6A2_ENST00000414754.3_Missense_Mutation_p.V245F	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	245			V -> I (in dbSNP:rs1805066).		synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	GATGGTCGTCGTCATCGTCTT	0.527000													9	68					0.000673444	0.000731093	1	1	0
LILRB1	10859	broad.mit.edu	37	19	55144760	55144760	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:55144760G>T	ENST00000396331.1	+	8	1609	c.1252G>T	c.(1252-1254)Gtg>Ttg	p.V418L	LILRB1_ENST00000427581.2_Missense_Mutation_p.V454L|LILRB1_ENST00000448689.1_Missense_Mutation_p.V418L|LILRB1_ENST00000434867.2_Missense_Mutation_p.V418L|LILRB1_ENST00000418536.2_Missense_Mutation_p.V418L|LILRB1_ENST00000462628.1_Intron|LILRB1_ENST00000396315.1_Missense_Mutation_p.V418L|LILRB1_ENST00000396317.1_Missense_Mutation_p.V418L|LILRB1_ENST00000396321.2_Missense_Mutation_p.V418L|LILRB1_ENST00000396332.4_Missense_Mutation_p.V418L|LILRB1_ENST00000324602.7_Missense_Mutation_p.V418L|LILRB1_ENST00000396327.3_Missense_Mutation_p.V418L	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	418					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CCTGGAGCTCGTGGTCTCAGG	0.642000										HNSCC(37;0.09)			49	107					6.3091e-27	1.06681e-26	1	1	0
LILRB1	10859	broad.mit.edu	37	19	55144591	55144591	+	Silent	SNP	G	G	T	rs12971424		TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:55144591G>T	ENST00000396331.1	+	8	1440	c.1083G>T	c.(1081-1083)ggG>ggT	p.G361G	LILRB1_ENST00000427581.2_Silent_p.G397G|LILRB1_ENST00000448689.1_Silent_p.G361G|LILRB1_ENST00000434867.2_Silent_p.G361G|LILRB1_ENST00000418536.2_Silent_p.G361G|LILRB1_ENST00000396315.1_Silent_p.G361G|LILRB1_ENST00000396317.1_Silent_p.G361G|LILRB1_ENST00000396321.2_Silent_p.G361G|LILRB1_ENST00000396332.4_Silent_p.G361G|LILRB1_ENST00000324602.7_Silent_p.G361G|LILRB1_ENST00000396327.3_Silent_p.G361G	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	361	Ig-like C2-type 4.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CCAAGGAGGGGGCAGCTGATG	0.577000										HNSCC(37;0.09)			29	92					1.75199e-13	2.53266e-13	1	1	0
TRAV12-3	28672	broad.mit.edu	37	14	22434157	22434157	+	RNA	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr14:22434157G>T	ENST00000390442.3	+	0	266																											AGTTGCTGATGTACACATACT	0.438000													27	217					4.74835e-14	6.97258e-14	1	1	0
LRRC55	219527	broad.mit.edu	37	11	56950055	56950055	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:56950055G>T	ENST00000497933.1	+	1	835	c.688G>T	c.(688-690)Ggg>Tgg	p.G230W		NM_001005210.2	NP_001005210.1	Q6ZSA7	LRC55_HUMAN	leucine rich repeat containing 55	200	LRRCT.					integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(13)|ovary(2)|skin(2)	25						GGGCCTACCGGGGCTGGTGAC	0.642000													33	143					1.15505e-17	1.81554e-17	1	1	0
MTR	4548	broad.mit.edu	37	1	236973820	236973820	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:236973820G>T	ENST00000366577.5	+	5	821	c.427G>T	c.(427-429)Gca>Tca	p.A143S	MTR_ENST00000535889.1_Missense_Mutation_p.A143S|MTR_ENST00000418145.2_Missense_Mutation_p.A199S	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	143	Hcy-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	GAGGTTTGTGGCAGGGGCTCT	0.398000													31	158					9.85521e-28	1.67659e-27	1	1	0
SSTR4	6754	broad.mit.edu	37	20	23017214	23017214	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:23017214C>T	ENST00000255008.3	+	1	1158	c.1094C>T	c.(1093-1095)cCc>cTc	p.P365L	RP4-753D10.3_ENST00000440921.1_RNA	NM_001052.2	NP_001043.2	P31391	SSR4_HUMAN	somatostatin receptor 4	365				P -> K (in Ref. 2; AAA60565).	G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	32	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CCCCCACTCCCCTGCCAGCAG	0.652000													37	90					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10323357	10323357	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:10323357G>A	ENST00000403437.2	-	3	282	c.188C>T	c.(187-189)aCc>aTc	p.T63I	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	63	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						AGTCTTTACGGTTACTTTCCC	0.418000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				81	252					0	0	1	0	0
AEBP1	165	broad.mit.edu	37	7	44148933	44148933	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:44148933G>C	ENST00000223357.3	+	9	1448	c.1143G>C	c.(1141-1143)gaG>gaC	p.E381D	AEBP1_ENST00000454218.1_3'UTR	NM_001129.3	NP_001120.3	Q8IUX7	AEBP1_HUMAN	AE binding protein 1	381					cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(13)|upper_aerodigestive_tract(2)	33						CGCCTACGGAGAAAGTCAGTA	0.622000													9	24					0	0	1	0	0
VPS13A	23230	broad.mit.edu	37	9	80022476	80022476	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:80022476A>G	ENST00000360280.3	+	71	9687	c.9427A>G	c.(9427-9429)Aga>Gga	p.R3143G	VPS13A_ENST00000376646.3_Missense_Mutation_p.R79G|VPS13A_ENST00000376636.3_Missense_Mutation_p.R3104G|VPS13A_ENST00000484581.2_Missense_Mutation_p.R79G	NM_033305.2	NP_150648.2	Q96RL7	VP13A_HUMAN	vacuolar protein sorting 13 homolog A (S. cerevisiae)	3143					Golgi to endosome transport|protein transport	intracellular	protein binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(28)|liver(1)|lung(42)|ovary(3)|pancreas(3)|prostate(3)|skin(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						ATTTCATGCCAGAGAGTTTGG	0.318000													18	31					0	0	1	0	0
CEACAM18	729767	broad.mit.edu	37	19	51983761	51983761	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:51983761A>T	ENST00000396477.4	+	2	248	c.227A>T	c.(226-228)cAc>cTc	p.H76L	CEACAM18_ENST00000451626.1_Missense_Mutation_p.H137L	NM_001278392.1	NP_001265321.1	A8MTB9	CEA18_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 18	137						integral to membrane				breast(1)|endometrium(4)|large_intestine(3)|lung(8)|skin(1)	17		all_neural(266;0.0529)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		ATTATCAGCCACAAACCGCCC	0.552000													3	21					0	0	1	0	0
ATRX	546	broad.mit.edu	37	X	76777777	76777777	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:76777777C>A	ENST00000373344.5	-	32	7153	c.6939G>T	c.(6937-6939)ttG>ttT	p.L2313F	ATRX_ENST00000480283.1_5'UTR|ATRX_ENST00000395603.3_Missense_Mutation_p.L2275F	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	2313					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	ACAGGGCTCCCAAATTGAAAG	0.403000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						58	53					5.43229e-20	8.76075e-20	1	1	0
CHD7	55636	broad.mit.edu	37	8	61777627	61777627	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:61777627G>T	ENST00000423902.2	+	38	8608	c.8129G>T	c.(8128-8130)cGg>cTg	p.R2710L	CHD7_ENST00000524602.1_Missense_Mutation_p.R661L	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2710					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CCTGTAGTGCGGGGAGAGGGA	0.592000													6	16					5.18039e-06	6.02221e-06	1	1	0
ATP2B2	491	broad.mit.edu	37	3	10443856	10443856	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:10443856A>T	ENST00000397077.1	-	6	1149	c.574T>A	c.(574-576)Ttt>Att	p.F192I	ATP2B2_ENST00000360273.2_Missense_Mutation_p.F192I|ATP2B2_ENST00000352432.4_Missense_Mutation_p.F192I|ATP2B2_ENST00000343816.4_Missense_Mutation_p.F192I|ATP2B2_ENST00000383800.4_Missense_Mutation_p.F192I			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	192					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						ACCACGGTAAATTTCTGTTCC	0.567000													67	298					0	0	1	0	0
CCDC120	90060	broad.mit.edu	37	X	48924721	48924721	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:48924721C>T	ENST00000376396.3	+	10	1185	c.966C>T	c.(964-966)ggC>ggT	p.G322G	CCDC120_ENST00000603986.1_Silent_p.G357G|CCDC120_ENST00000597275.1_Silent_p.G322G|CCDC120_ENST00000536628.2_Silent_p.G310G|CCDC120_ENST00000496529.2_Silent_p.G322G|CCDC120_ENST00000422185.2_Silent_p.G322G	NM_001271835.1|NM_001271836.1|NM_033626.2	NP_001258764.1|NP_001258765.1|NP_296375.1	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120	322							protein binding			breast(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	14						GACCTGAAGGCCTTCATTCTC	0.637000													5	37					0	0	1	0	0
S100A7L2	645922	broad.mit.edu	37	1	153409561	153409561	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:153409561C>A	ENST00000368725.2	-	3	311	c.312G>T	c.(310-312)gtG>gtT	p.V104V		NM_001045479.1	NP_001038944.2			S100 calcium binding protein A7-like 2											NS(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	8	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			AACAGGGTGCCACTCCATGCA	0.473000													26	260					2.61193e-14	3.86594e-14	1	1	0
SEMA6D	80031	broad.mit.edu	37	15	48056493	48056493	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr15:48056493C>A	ENST00000316364.5	+	11	1527	c.1088C>A	c.(1087-1089)cCa>cAa	p.P363Q	SEMA6D_ENST00000537942.1_Missense_Mutation_p.P363Q|SEMA6D_ENST00000558014.1_Missense_Mutation_p.P363Q|SEMA6D_ENST00000354744.4_Missense_Mutation_p.P363Q|SEMA6D_ENST00000358066.4_Missense_Mutation_p.P363Q|SEMA6D_ENST00000536845.2_Missense_Mutation_p.P363Q|SEMA6D_ENST00000355997.3_Missense_Mutation_p.P363Q|SEMA6D_ENST00000389428.3_Missense_Mutation_p.P363Q|SEMA6D_ENST00000389432.2_Missense_Mutation_p.P363Q|SEMA6D_ENST00000389433.2_Missense_Mutation_p.P363Q|SEMA6D_ENST00000389425.3_Missense_Mutation_p.P363Q|SEMA6D_ENST00000558816.1_Missense_Mutation_p.P363Q	NM_153618.1	NP_705871.1	Q8NFY4	SEM6D_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	363	Sema.				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			biliary_tract(1)|breast(4)|endometrium(4)|kidney(5)|large_intestine(10)|lung(42)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	77		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		GACAAAGTGCCAAAGCCAAGG	0.433000													14	27					1.05317e-09	1.38275e-09	1	1	0
GABRA2	2555	broad.mit.edu	37	4	46307694	46307694	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:46307694C>A	ENST00000510861.1	-	7	767	c.594G>T	c.(592-594)tgG>tgT	p.W198C	GABRA2_ENST00000507069.1_Missense_Mutation_p.W198C|GABRA2_ENST00000381620.4_Missense_Mutation_p.W198C|GABRA2_ENST00000514090.1_Missense_Mutation_p.W198C|GABRA2_ENST00000356504.1_Missense_Mutation_p.W198C|GABRA2_ENST00000540012.1_Missense_Mutation_p.W143C|GABRA2_ENST00000515082.1_Missense_Mutation_p.W198C			P47869	GBRA2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 2	198					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity	p.W198F(1)|p.W198C(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	56					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CATTGTAAGTCCAAATATAAG	0.358000													7	50					8.12818e-05	9.14421e-05	1	1	0
KIR3DL1	3811	broad.mit.edu	37	19	55331266	55331266	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:55331266C>A	ENST00000391728.4	+	4	487	c.454C>A	c.(454-456)Cac>Aac	p.H152N	KIR3DL1_ENST00000326542.7_Missense_Mutation_p.H152N|KIR3DL1_ENST00000358178.4_Missense_Mutation_p.H57N|KIR3DL1_ENST00000541392.1_Missense_Mutation_p.H152N|KIR3DL1_ENST00000402254.2_Missense_Mutation_p.H152N|KIR3DL1_ENST00000538269.1_Missense_Mutation_p.H152N	NM_013289.2	NP_037421.2			killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1											breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11				GBM - Glioblastoma multiforme(193;0.0192)		CATGTTTGAGCACTTCTTTCT	0.522000													12	145					0.000219431	0.000242461	1	1	0
MYH1	4619	broad.mit.edu	37	17	10395748	10395748	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:10395748G>A	ENST00000226207.5	-	40	5899	c.5805C>T	c.(5803-5805)atC>atT	p.I1935I	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_005963.3	NP_005954.3	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	1935						muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(7)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(22)|lung(78)|ovary(11)|pancreas(1)|prostate(3)|skin(13)|upper_aerodigestive_tract(4)|urinary_tract(5)	176						CTTCACTTATGATTTTTGTGT	0.448000													58	263					0	0	1	0	0
PCDHGA9	56107	broad.mit.edu	37	5	140783057	140783057	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:140783057C>A	ENST00000573521.1	+	1	538	c.538C>A	c.(538-540)Ctg>Atg	p.L180M	PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_018921.2|NM_032089.1	NP_061744.1|NP_114478.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACTTCTCCCTGAACGTGCA	0.587000													30	77					1.36161e-19	2.18957e-19	1	1	0
ARIH1	25820	broad.mit.edu	37	15	72873301	72873301	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr15:72873301T>C	ENST00000379887.4	+	12	1759	c.1445T>C	c.(1444-1446)cTc>cCc	p.L482P	ARIH1_ENST00000562891.1_Intron	NM_005744.3	NP_005735.2	Q9Y4X5	ARI1_HUMAN	ariadne RBR E3 ubiquitin protein ligase 1	482					ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	14						GCTTTCTACCTCAAAAAGAAT	0.433000													4	157					0	0	1	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188444	140188444	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:140188444G>A	ENST00000530339.1	+	1	1672	c.1672G>A	c.(1672-1674)Gaa>Aaa	p.E558K	PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Missense_Mutation_p.E558K|PCDHA4_ENST00000356878.4_Missense_Mutation_p.E558K|PCDHA1_ENST00000394633.3_Intron	NM_018907.2	NP_061730.1														breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(6)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGTGCTGGACGAAAACGACAA	0.667000													9	91					0	0	1	0	0
TEX37	200523	broad.mit.edu	37	2	88828978	88828978	+	Missense_Mutation	SNP	C	C	T	rs140462695		TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:88828978C>T	ENST00000303254.3	+	4	671	c.529C>T	c.(529-531)Cca>Tca	p.P177S		NM_152670.2	NP_689883.1			testis expressed 37																		ACCCTTGATGCCATTTTACCA	0.493000													5	43					0	0	1	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955912	18955912	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:18955912C>A	ENST00000302797.3	-	1	644	c.420G>T	c.(418-420)gcG>gcT	p.A140A	MRGPRX1_ENST00000526914.1_5'UTR	NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	140					acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						CACACACCACCGCTGACAGGT	0.622000													22	137					1.77063e-15	2.64883e-15	1	1	0
PCDHA10	56139	broad.mit.edu	37	5	140237241	140237241	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:140237241G>A	ENST00000307360.5	+	1	1608	c.1608G>A	c.(1606-1608)gcG>gcA	p.A536A	PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGTGAGCGCGCGCGATGGGG	0.677000													63	121					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000556131.1_Missense_Mutation_p.G12C|KRAS_ENST00000557334.1_Missense_Mutation_p.G12C|KRAS_ENST00000256078.4_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			6	30					2.17888e-05	2.50683e-05	1	1	0
GIMAP7	168537	broad.mit.edu	37	7	150217064	150217064	+	Translation_Start_Site	SNP	T	T	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:150217064T>G	ENST00000313543.4	+	2	159	c.2T>G	c.(1-3)aTg>aGg	p.M1R		NM_153236.3	NP_694968.1	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	1							GTP binding			breast(1)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	17			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GACGTGAGCATGGCTGAGAGT	0.493000													7	55					0	0	1	0	0
PSD3	23362	broad.mit.edu	37	8	18729563	18729563	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:18729563C>A	ENST00000440756.2	-	3	913	c.811G>T	c.(811-813)Gag>Tag	p.E271*	PSD3_ENST00000327040.8_Nonsense_Mutation_p.E271*|PSD3_ENST00000523619.1_Nonsense_Mutation_p.E206*			Q9NYI0	PSD3_HUMAN	pleckstrin and Sec7 domain containing 3	271					regulation of ARF protein signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	ARF guanyl-nucleotide exchange factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(8)|ovary(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(111;0.0281)|READ - Rectum adenocarcinoma(644;0.183)		GACCTCTGCTCTTTCAAGAAA	0.577000													22	29					7.87624e-14	1.14452e-13	1	1	0
SLCO1B3	28234	broad.mit.edu	37	12	21015716	21015716	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:21015716G>T	ENST00000381545.3	+	8	874	c.655G>T	c.(655-657)Ggt>Tgt	p.G219C	SLCO1B3_ENST00000261196.2_Missense_Mutation_p.G219C|SLCO1B7_ENST00000554957.1_Intron|SLCO1B3_ENST00000553473.1_Missense_Mutation_p.G219C|LST3_ENST00000381541.3_Intron|LST3_ENST00000540229.1_Missense_Mutation_p.G219C	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	219					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					AGGAATGATTGGTCCAGTCAT	0.333000													36	93					2.77807e-22	4.59989e-22	1	1	0
TTI1	9675	broad.mit.edu	37	20	36641192	36641192	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:36641192C>A	ENST00000373448.2	-	3	1265	c.1027G>T	c.(1027-1029)Gag>Tag	p.E343*	TTI1_ENST00000373447.3_Nonsense_Mutation_p.E343*|TTI1_ENST00000449821.1_Nonsense_Mutation_p.E343*|TTI1_ENST00000487362.1_Intron	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	343							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						TCAGGACTCTCATCATTTACT	0.458000													28	88					9.17885e-22	1.50641e-21	1	1	0
ZNF850	342892	broad.mit.edu	37	19	37239983	37239983	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:37239983G>T	ENST00000591344.1	-	5	2117	c.1959C>A	c.(1957-1959)gcC>gcA	p.A653A	ZNF850_ENST00000589390.1_Intron	NM_001193552.1|NM_001267779.1	NP_001180481.1|NP_001254708.1	A8MQ14	ZN850_HUMAN	zinc finger protein 850	653					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding										CACTGACAAAGGCTTTCCCAC	0.453000													4	13					0.150653	0.153123	1	1	0
F5	2153	broad.mit.edu	37	1	169524574	169524574	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:169524574C>A	ENST00000367796.3	-	7	1165	c.964G>T	c.(964-966)Gct>Tct	p.A322S	F5_ENST00000546081.1_Missense_Mutation_p.A185S|F5_ENST00000367797.3_Missense_Mutation_p.A322S			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	322	F5/8 type A 1.|Plastocyanin-like 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	TCAATGTAAGCCTGCATCCCA	0.388000													9	34					1.08611e-07	1.34977e-07	1	1	0
PLEKHA7	144100	broad.mit.edu	37	11	16812603	16812603	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:16812603C>A	ENST00000355661.3	-	20	2899	c.2889G>T	c.(2887-2889)agG>agT	p.R963S	PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000531066.1_Missense_Mutation_p.R963S|PLEKHA7_ENST00000448080.2_Missense_Mutation_p.R964S|PLEKHA7_ENST00000332954.4_5'UTR			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	963					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						GGTCTCGCTTCCTCTCGTCTG	0.662000													34	84					1.22674e-20	1.99569e-20	1	1	0
SRCAP	10847	broad.mit.edu	37	16	30735499	30735499	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:30735499C>A	ENST00000262518.4	+	25	5139	c.4754C>A	c.(4753-4755)aCc>aAc	p.T1585N	SRCAP_ENST00000344771.4_Missense_Mutation_p.T1427N|SRCAP_ENST00000395059.2_Missense_Mutation_p.T1523N	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1585	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			GCTCTAGCCACCCCTCTGGCT	0.607000													11	87					7.45023e-12	1.04453e-11	1	1	0
CERCAM	51148	broad.mit.edu	37	9	131193498	131193498	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:131193498G>A	ENST00000372842.1	+	10	4029	c.885G>A	c.(883-885)ccG>ccA	p.P295P	CERCAM_ENST00000372838.4_Silent_p.P373P			Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule	373					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				endometrium(2)|kidney(4)|large_intestine(2)|lung(9)|ovary(1)|pancreas(2)	20						ACCTGCTCCCGGGCTACCAGG	0.637000													6	218					0	0	1	0	0
FAM135B	51059	broad.mit.edu	37	8	139163953	139163953	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:139163953C>A	ENST00000395297.1	-	13	2935	c.2765G>T	c.(2764-2766)gGc>gTc	p.G922V		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	922										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTCTGAGATGCCACTGTTGGA	0.507000										HNSCC(54;0.14)			71	94					1.4051e-37	2.46556e-37	1	1	0
OR13C5	138799	broad.mit.edu	37	9	107361002	107361002	+	Silent	SNP	C	C	A	rs78992791	byFrequency	TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:107361002C>A	ENST00000374779.2	-	1	786	c.693G>T	c.(691-693)tcG>tcT	p.S231S		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						TTCTCCCCTCCGAAGAGCTAA	0.428000													52	62					9.72345e-25	1.63424e-24	1	1	0
OR51S1	119692	broad.mit.edu	37	11	4870006	4870006	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:4870006T>A	ENST00000322101.2	-	1	508	c.433A>T	c.(433-435)Acc>Tcc	p.T145S	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	145					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACACCATTGGTGAGGAGCGCT	0.542000													41	122					0	0	1	0	0
FZD1	8321	broad.mit.edu	37	7	90895851	90895851	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:90895851C>T	ENST00000287934.2	+	1	2069	c.1656C>T	c.(1654-1656)atC>atT	p.I552I		NM_003505.1	NP_003496.1	Q9UP38	FZD1_HUMAN	frizzled family receptor 1	552					autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|liver(1)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			CCATCGTCATCGCCTGCTACT	0.607000													13	41					0	0	1	0	0
PRAMEF6	440561	broad.mit.edu	37	1	13001263	13001263	+	Missense_Mutation	SNP	C	C	G	rs150586267		TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:13001263C>G	ENST00000376189.1	-	3	519	c.420G>C	c.(418-420)agG>agC	p.R140S	PRAMEF6_ENST00000376192.5_Intron|PRAMEF6_ENST00000415464.2_Missense_Mutation_p.R140S	NM_001010889.2	NP_001010889.1	Q5VXH4	PRAM6_HUMAN	PRAME family member 6	140										NS(1)|kidney(1)|lung(5)|urinary_tract(2)	9	Ovarian(185;0.249)	Lung NSC(185;3.67e-05)|all_lung(284;4.03e-05)|Renal(390;0.000147)|Breast(348;0.000278)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GTCCTCTCATCCTTGGACAGT	0.507000													47	654					0	0	1	0	0
AGK	55750	broad.mit.edu	37	7	141296405	141296405	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:141296405A>T	ENST00000355413.4	+	4	445	c.185A>T	c.(184-186)aAg>aTg	p.K62M	AGK_ENST00000495028.1_3'UTR|AGK_ENST00000535825.1_Missense_Mutation_p.K62M|AGK_ENST00000473247.1_Missense_Mutation_p.K34M	NM_018238.3	NP_060708.1	Q53H12	AGK_HUMAN	acylglycerol kinase	62	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(3)	17	Melanoma(164;0.0171)					CAAGTGAAGAAGGCCACTGTT	0.378000													22	121					0	0	1	0	0
SLC7A14	57709	broad.mit.edu	37	3	170216597	170216597	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:170216597C>A	ENST00000231706.4	-	4	933	c.618G>T	c.(616-618)ggG>ggT	p.G206G	CLDN11_ENST00000486975.1_Intron|CLDN11_ENST00000451576.1_Intron	NM_020949.2	NP_066000.2	Q8TBB6	S7A14_HUMAN	solute carrier family 7, member 14	206						integral to membrane	amino acid transmembrane transporter activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|liver(1)|lung(23)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(4)	53	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			AATTCTTCACCCCCAGAGCAA	0.463000													4	93					0.014758	0.0153924	1	1	0
CNPY3	10695	broad.mit.edu	37	6	42905454	42905454	+	Splice_Site	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:42905454G>T	ENST00000372836.4	+	4	743		c.e4-1		CNPY3_ENST00000394142.3_Splice_Site	NM_006586.3	NP_006577.2	Q9BT09	CNPY3_HUMAN	canopy FGF signaling regulator 3						innate immune response	endoplasmic reticulum				central_nervous_system(1)|endometrium(1)|lung(3)|ovary(1)	6	Colorectal(47;0.196)		all cancers(41;0.000954)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			GCTTCTTCCAGGGCATGTCAG	0.542000													74	174					2.88734e-31	5.00352e-31	1	1	0
GUCY1A2	2977	broad.mit.edu	37	11	106680718	106680718	+	Splice_Site	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:106680718C>A	ENST00000526355.1	-	5	2161		c.e5+1		GUCY1A2_ENST00000347596.2_Splice_Site|GUCY1A2_ENST00000282249.2_Splice_Site	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2						intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		AACTCCCTTACCTTATAAATA	0.313000													3	65					1	1	1	1	0
PPP1R15B	84919	broad.mit.edu	37	1	204380470	204380470	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:204380470A>G	ENST00000367188.4	-	1	449	c.70T>C	c.(70-72)Ttt>Ctt	p.F24L	RP11-739N20.2_ENST00000443515.1_RNA	NM_032833.3	NP_116222.3	Q5SWA1	PR15B_HUMAN	protein phosphatase 1, regulatory subunit 15B	24					regulation of translation					breast(3)|cervix(1)|kidney(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(2)|skin(1)|urinary_tract(3)	34	all_cancers(21;0.0032)|all_neural(3;0.0218)|Glioma(3;0.0382)|Breast(84;0.179)|all_epithelial(62;0.193)|Prostate(682;0.227)		all cancers(3;1.14e-29)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.139)			CGAGGGAAAAAGGGTGGCCAG	0.627000													3	111					0	0	1	0	0
GPAA1	8733	broad.mit.edu	37	8	145139400	145139400	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:145139400G>T	ENST00000355091.4	+	7	1019	c.898G>T	c.(898-900)Ggc>Tgc	p.G300C	GPAA1_ENST00000361036.6_Missense_Mutation_p.G240C|GPAA1_ENST00000527144.1_3'UTR	NM_003801.3	NP_003792.1	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment 1	300					attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(2)	19	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCAGGCCTCCGGCCGCCCCCA	0.627000													19	94					8.10497e-08	1.0209e-07	1	1	0
KLK6	5653	broad.mit.edu	37	19	51466592	51466592	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:51466592G>A	ENST00000376851.3	-	4	850	c.411C>T	c.(409-411)agC>agT	p.S137S	KLK6_ENST00000310157.2_Silent_p.S137S|CTB-147C22.8_ENST00000601506.1_RNA|KLK6_ENST00000594641.1_Silent_p.S137S|KLK6_ENST00000456750.2_Silent_p.S30S|KLK6_ENST00000391808.1_Silent_p.S30S|KLK6_ENST00000376853.4_Intron	NM_001012964.1	NP_001012982.1	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6	137	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|skin(4)	13		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		GGATGTGGCAGCTGGTGGTGT	0.612000													41	71					0	0	1	0	0
MRPS7	51081	broad.mit.edu	37	17	73258723	73258723	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:73258723G>C	ENST00000579761.1	+	2	456	c.229G>C	c.(229-231)Gct>Cct	p.A77P	MRPS7_ENST00000245539.6_Missense_Mutation_p.A77P|MRPS7_ENST00000579002.1_Missense_Mutation_p.A106P			Q9Y2R9	RT07_HUMAN	mitochondrial ribosomal protein S7	77					translation	cytosolic small ribosomal subunit|mitochondrion	protein binding|RNA binding|structural constituent of ribosome			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)	6	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			CATCAAAGCTGCTCCAGCAGG	0.468000													19	223					0	0	1	0	0
FAR2	55711	broad.mit.edu	37	12	29485635	29485635	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:29485635C>A	ENST00000182377.4	+	11	1628	c.1360C>A	c.(1360-1362)Cca>Aca	p.P454T	FAR2_ENST00000547116.1_Missense_Mutation_p.P357T|FAR2_ENST00000536681.2_Missense_Mutation_p.P454T	NM_018099.3	NP_060569.3	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	454					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor			central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|prostate(1)|stomach(1)	29						GGCTGGGATCCCAAAAGCAAA	0.353000													3	39					0.115264	0.11823	1	1	0
TRIML1	339976	broad.mit.edu	37	4	189068113	189068113	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:189068113G>C	ENST00000332517.3	+	6	1134	c.994G>C	c.(994-996)Ggt>Cgt	p.G332R	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	332	B30.2/SPRY.				multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		GACTGTGCTGGGTACTCAGAT	0.537000													9	66					0	0	1	0	0
CARS	833	broad.mit.edu	37	11	3038339	3038339	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:3038339C>T	ENST00000397114.3	-	16	2011	c.1635G>A	c.(1633-1635)ctG>ctA	p.L545L	CARS_ENST00000380525.4_Silent_p.L638L|CARS_ENST00000401769.3_Silent_p.L568L|CARS_ENST00000278224.9_Silent_p.L555L|CARS_ENST00000397111.5_Silent_p.L555L			P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase	555					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|tRNA binding		CARS/ALK(5)	central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(14)|ovary(3)|skin(1)	31		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	GGCTTACCTTCAGCATATGGG	0.617000			T	ALK	ALCL								7	56					0	0	1	0	0
WDR81	124997	broad.mit.edu	37	17	1637107	1637107	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:1637107C>A	ENST00000409644.1	+	7	4776	c.4776C>A	c.(4774-4776)ggC>ggA	p.G1592G	WDR81_ENST00000437219.2_Silent_p.G389G|WDR81_ENST00000446363.1_Silent_p.G231G|WDR81_ENST00000309182.5_Silent_p.G541G|WDR81_ENST00000545662.1_Silent_p.G223G|RP11-961A15.1_ENST00000576540.1_RNA|WDR81_ENST00000419248.1_Silent_p.G365G	NM_001163809.1	NP_001157281.1	B3KXU1	B3KXU1_HUMAN	WD repeat domain 81	365										cervix(1)|endometrium(1)|kidney(3)|lung(6)|ovary(2)|prostate(2)|skin(1)	16				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		GTGGCGGGGGCCTGGGCAGCG	0.682000													3	69					0.00024832	0.000273299	1	1	0
KRT25	147183	broad.mit.edu	37	17	38910715	38910715	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:38910715G>A	ENST00000312150.4	-	2	495	c.435C>T	c.(433-435)atC>atT	p.I145I		NM_181534.3	NP_853512.1	Q7Z3Z0	K1C25_HUMAN	keratin 25	145	Coil 1B.|Rod.					cytoplasm|intermediate filament	structural molecule activity			endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(4)	16		Breast(137;0.00526)				TGGTGGATGCGATGATCTAGA	0.368000													26	99					0	0	1	0	0
SLC7A8	23428	broad.mit.edu	37	14	23597256	23597256	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr14:23597256G>T	ENST00000316902.7	-	10	2138	c.1413C>A	c.(1411-1413)caC>caA	p.H471Q	SLC7A8_ENST00000422941.2_Missense_Mutation_p.H247Q|SLC7A8_ENST00000469263.1_Intron|SLC7A8_ENST00000529705.2_Missense_Mutation_p.H366Q|SLC7A8_ENST00000453702.1_Missense_Mutation_p.H268Q	NM_012244.3	NP_036376.2	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 8	471					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			autonomic_ganglia(1)|endometrium(6)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|skin(1)	24	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	ACTTGGGCTTGTGTTGCCAGT	0.562000													21	36					6.36457e-07	7.63749e-07	1	1	0
DRD2	1813	broad.mit.edu	37	11	113286297	113286297	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:113286297A>T	ENST00000362072.3	-	5	913	c.569T>A	c.(568-570)gTg>gAg	p.V190E	DRD2_ENST00000542968.1_Missense_Mutation_p.V190E|DRD2_ENST00000355319.2_Missense_Mutation_p.V190E|DRD2_ENST00000535984.1_5'UTR|DRD2_ENST00000346454.3_Missense_Mutation_p.V190E|DRD2_ENST00000544518.1_Missense_Mutation_p.V189E|DRD2_ENST00000538967.1_Missense_Mutation_p.V190E	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	190	Agonist binding (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GGAGTAGACCACGAAGGCCGG	0.597000													6	27					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100169914	100169914	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:100169914G>T	ENST00000524871.1	+	20	2696	c.2406G>T	c.(2404-2406)caG>caT	p.Q802H	CNTN5_ENST00000279463.3_Missense_Mutation_p.Q802H|CNTN5_ENST00000528682.1_Missense_Mutation_p.Q802H|CNTN5_ENST00000418526.2_Missense_Mutation_p.Q728H|CNTN5_ENST00000527185.1_Missense_Mutation_p.Q802H|CNTN5_ENST00000524560.1_3'UTR	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	802	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AAGAGTTTCAGAATGGGGAAG	0.343000													4	9					0.0293803	0.030416	1	1	0
ZNF148	7707	broad.mit.edu	37	3	124951807	124951807	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:124951807C>A	ENST00000360647.4	-	9	2248	c.1763G>T	c.(1762-1764)gGa>gTa	p.G588V	ZNF148_ENST00000492394.1_Missense_Mutation_p.G588V|SLC12A8_ENST00000423114.2_Intron|ZNF148_ENST00000468369.1_Intron|ZNF148_ENST00000497929.1_5'UTR|ZNF148_ENST00000484491.1_Missense_Mutation_p.G588V|ZNF148_ENST00000544464.1_Intron|ZNF148_ENST00000485866.1_Missense_Mutation_p.G588V	NM_021964.2	NP_068799.2	Q9UQR1	ZN148_HUMAN	zinc finger protein 148	588					cellular defense response|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(3)	28						GGAGCTTGATCCAACATTCTC	0.443000													41	90					8.00217e-19	1.27577e-18	1	1	0
ZNF845	91664	broad.mit.edu	37	19	53856702	53856702	+	Missense_Mutation	SNP	G	G	A	rs150688663	by1000genomes	TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:53856702G>A	ENST00000458035.1	+	4	2891	c.2774G>A	c.(2773-2775)cGt>cAt	p.R925H	ZNF845_ENST00000595091.1_Missense_Mutation_p.R925H	NM_138374.1	NP_612383.1	Q96IR2	ZN845_HUMAN	zinc finger protein 845	925					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R925H(3)		endometrium(2)|kidney(10)|lung(7)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(2)	26						AAAACCTTCCGTCACAATTCA	0.363000													3	50					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10303933	10303933	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:10303933C>G	ENST00000403437.2	-	27	3603	c.3509G>C	c.(3508-3510)cGg>cCg	p.R1170P	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1170					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CTCAGCCTCCCGCTTCTTGTT	0.582000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				7	189					0	0	1	0	0
NELL2	4753	broad.mit.edu	37	12	44913867	44913867	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:44913867A>T	ENST00000429094.2	-	19	2825	c.2321T>A	c.(2320-2322)cTg>cAg	p.L774Q	NELL2_ENST00000437801.2_Missense_Mutation_p.L824Q|NELL2_ENST00000551601.1_Missense_Mutation_p.L726Q|NELL2_ENST00000333837.4_Missense_Mutation_p.L797Q|NELL2_ENST00000395487.2_Missense_Mutation_p.L773Q|NELL2_ENST00000549027.1_Missense_Mutation_p.L773Q|NELL2_ENST00000452445.2_Missense_Mutation_p.L774Q	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	774	VWFC 5.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		CATTTCGTCCAGGCAAGTCTT	0.498000													16	87					0	0	1	0	0
PTGER3	5733	broad.mit.edu	37	1	71512441	71512441	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:71512441C>A	ENST00000370924.4	-	1	1050	c.820G>T	c.(820-822)Ggc>Tgc	p.G274C	PTGER3_ENST00000370931.3_Missense_Mutation_p.G274C|PTGER3_ENST00000306666.5_Missense_Mutation_p.G274C|PTGER3_ENST00000354608.5_Missense_Mutation_p.G274C|PTGER3_ENST00000351052.5_Missense_Mutation_p.G274C|PTGER3_ENST00000460330.1_Missense_Mutation_p.G274C|PTGER3_ENST00000370932.2_Missense_Mutation_p.G274C|PTGER3_ENST00000414819.1_Missense_Mutation_p.G274C|PTGER3_ENST00000356595.4_Missense_Mutation_p.G274C	NM_198715.2	NP_942008.1	P43115	PE2R3_HUMAN	prostaglandin E receptor 3 (subtype EP3)	274					cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			endometrium(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25					Bimatoprost(DB00905)	GTGATGCGGCCCCACTGGGCA	0.637000													5	55					0.00116845	0.001266	1	1	0
ZNF335	63925	broad.mit.edu	37	20	44594382	44594382	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:44594382C>A	ENST00000322927.2	-	7	1087	c.987G>T	c.(985-987)gaG>gaT	p.E329D	ZNF335_ENST00000426788.1_Missense_Mutation_p.E174D	NM_022095.3	NP_071378.1	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	329					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(13)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	51		Myeloproliferative disorder(115;0.0122)				GGCCTCGGGGCTCATCCTCAG	0.657000													32	90					1.47197e-15	2.21391e-15	1	1	0
FBN2	2201	broad.mit.edu	37	5	127744479	127744479	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:127744479G>T	ENST00000508053.1	-	14	1940	c.966C>A	c.(964-966)tgC>tgA	p.C322*	FBN2_ENST00000262464.4_Nonsense_Mutation_p.C322*|FBN2_ENST00000508989.1_Nonsense_Mutation_p.C289*			P35556	FBN2_HUMAN	fibrillin 2	322	EGF-like 5; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GAATGATGCTGCACTCATCAA	0.383000													23	92					1.36239e-07	1.67818e-07	1	1	0
DAO	1610	broad.mit.edu	37	12	109283320	109283320	+	Splice_Site	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:109283320G>T	ENST00000228476.3	+	4	589	c.386_splice	c.e4+1	p.G129_splice	DAO_ENST00000551281.1_Intron	NM_001917.4	NP_001908.3	P14920	OXDA_HUMAN	D-amino-acid oxidase	129					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|skin(1)	26						CCCAGATTACGGGTGAGTTTA	0.547000													20	68					3.01185e-09	3.89933e-09	1	1	0
GRM2	2912	broad.mit.edu	37	3	51749096	51749096	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:51749096A>T	ENST00000395052.3	+	4	1541	c.1307A>T	c.(1306-1308)gAc>gTc	p.D436V	GRM2_ENST00000442933.2_Missense_Mutation_p.D436V|GRM2_ENST00000475478.1_3'UTR	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	436					synaptic transmission	integral to plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	CGCCCAGCTGACACCCACAAT	0.547000													12	105					0	0	1	0	0
BPI	671	broad.mit.edu	37	20	36952395	36952395	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:36952395G>T	ENST00000262865.4	+	8	981	c.892G>T	c.(892-894)Ggg>Tgg	p.G298W	BPI_ENST00000489102.1_3'UTR|CTD-2308N23.2_ENST00000437016.1_RNA	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	298					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				CAACACAGCCGGGCTTGTATA	0.562000													12	40					0.000151284	0.000168161	1	1	0
ZNF761	388561	broad.mit.edu	37	19	53960356	53960356	+	RNA	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:53960356G>C	ENST00000454407.1	+	0	3048							Q86XN6	ZN761_HUMAN	zinc finger protein 761						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	30				GBM - Glioblastoma multiforme(134;0.00786)		AAAGCCTTTAGTAGGCAGTCA	0.433000													22	25					0	0	1	0	0
KRT80	144501	broad.mit.edu	37	12	52565216	52565216	+	Missense_Mutation	SNP	T	T	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:52565216T>G	ENST00000394815.2	-	9	1422	c.1325A>C	c.(1324-1326)aAg>aCg	p.K442T	KRT80_ENST00000313234.5_3'UTR	NM_182507.2	NP_872313.2	Q6KB66	K2C80_HUMAN	keratin 80	442	Tail.					keratin filament	structural molecule activity			endometrium(2)|large_intestine(2)|lung(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.108)		CGAGAAGTACTTCTCTGACAT	0.577000													6	133					0	0	1	0	0
CACNA1A	773	broad.mit.edu	37	19	13340930	13340930	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:13340930C>A	ENST00000360228.5	-	36	5493	c.5494G>T	c.(5494-5496)Gtg>Ttg	p.V1832L	CACNA1A_ENST00000574822.1_5'UTR|CACNA1A_ENST00000573710.2_Missense_Mutation_p.V1833L	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	1833					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CAGACACGCACGTACTCATCC	0.572000													12	46					1.15088e-07	1.42077e-07	1	1	0
NDUFAF6	137682	broad.mit.edu	37	8	96044273	96044273	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:96044273C>G	ENST00000396124.4	+	2	271	c.248C>G	c.(247-249)tCc>tGc	p.S83C	NDUFAF6_ENST00000542894.1_Missense_Mutation_p.S31C|NDUFAF6_ENST00000396113.1_5'UTR|NDUFAF6_ENST00000286687.4_5'UTR|NDUFAF6_ENST00000396111.2_5'UTR	NM_152416.3	NP_689629.2	Q330K2	CH038_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6	83					biosynthetic process	mitochondrion	transferase activity										CCTGCAGAATCCCGAAGCTCT	0.413000													11	107					0	0	1	0	0
PDE1B	5153	broad.mit.edu	37	12	54964027	54964027	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:54964027C>G	ENST00000243052.3	+	6	916	c.480C>G	c.(478-480)aaC>aaG	p.N160K	PDE1B_ENST00000550620.1_Missense_Mutation_p.N140K|PDE1B_ENST00000538346.1_Missense_Mutation_p.N119K|PDE1B_ENST00000394277.3_3'UTR	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	160					activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						CTCCATAGAACCTGGATCTCT	0.448000													4	60					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51900439	51900439	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:51900439C>A	ENST00000268919.4	+	1	201	c.45C>A	c.(43-45)ccC>ccA	p.P15P		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	15					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						GTCTCTCGCCCCTGAAACCCT	0.602000													9	60					3.86212e-05	4.40708e-05	1	1	0
ATG16L1	55054	broad.mit.edu	37	2	234200813	234200813	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:234200813G>C	ENST00000392017.4	+	15	1727	c.1470G>C	c.(1468-1470)aaG>aaC	p.K490N	ATG16L1_ENST00000392018.1_Missense_Mutation_p.K507N|ATG16L1_ENST00000392020.4_Missense_Mutation_p.K471N|ATG16L1_ENST00000347464.5_Missense_Mutation_p.K327N|ATG16L1_ENST00000373525.5_Missense_Mutation_p.K311N	NM_001190266.1|NM_001190267.1|NM_030803.6	NP_001177195.1|NP_001177196.1|NP_110430.5	Q676U5	A16L1_HUMAN	autophagy related 16-like 1 (S. cerevisiae)	490					autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(7)|prostate(3)|skin(1)	25		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		TGTTGGGAAAGATTACTGCCC	0.463000													10	78					0	0	1	0	0
CHRNA4	1137	broad.mit.edu	37	20	61990972	61990972	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:61990972G>T	ENST00000370263.4	-	2	377	c.156C>A	c.(154-156)tcC>tcA	p.S52S	CHRNA4_ENST00000463705.1_Intron	NM_000744.6|NM_001256573.1	NP_000735.1|NP_001243502.1	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 (neuronal)	52					B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	CCACGGGTCGGGACCACTTGT	0.647000													24	76					1.32181e-22	2.19515e-22	1	1	0
KRT36	8689	broad.mit.edu	37	17	39644573	39644573	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:39644573G>T	ENST00000393986.2	-	4	683	c.471C>A	c.(469-471)acC>acA	p.T157T	KRT36_ENST00000328119.6_Silent_p.T207T			O76013	KRT36_HUMAN	keratin 36	207	Coil 1B.|Rod.					intermediate filament	protein binding|structural constituent of epidermis			breast(2)|cervix(1)|kidney(2)|large_intestine(3)|lung(8)|skin(1)	17		Breast(137;0.000286)				CCTTGCACAGGGTCAGCTCAT	0.587000													44	115					1.07234e-20	1.75474e-20	1	1	0
TPTE	7179	broad.mit.edu	37	21	10970059	10970059	+	Silent	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr21:10970059T>A	ENST00000298232.7	-	6	436	c.69A>T	c.(67-69)ccA>ccT	p.P23P	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Silent_p.P23P|TPTE_ENST00000361285.4_Silent_p.P23P	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	23					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CACTTGTCTGTGGACTAGTGG	0.378000													15	163					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152128587	152128587	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:152128587G>T	ENST00000316073.3	-	3	1052	c.988C>A	c.(988-990)Cac>Aac	p.H330N		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	330	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding	p.H330N(1)		breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						TGACTGTAGTGGGAACTCTGG	0.483000													314	994					1.81266e-102	3.23151e-102	1	1	0
OR52E4	390081	broad.mit.edu	37	11	5905708	5905708	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:5905708C>T	ENST00000316987.2	+	1	208	c.186C>T	c.(184-186)ttC>ttT	p.F62F		NM_001005165.1	NP_001005165.1	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E, member 4	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(2)|prostate(1)|skin(2)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGCCCATGTTCTACTTCCTGG	0.433000													82	162					0	0	1	0	0
MAS1	4142	broad.mit.edu	37	6	160328731	160328731	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:160328731C>A	ENST00000252660.4	+	1	758	c.744C>A	c.(742-744)taC>taA	p.Y248*		NM_002377.2	NP_002368.1	P04201	MAS_HUMAN	MAS1 oncogene	248					anatomical structure morphogenesis|cell proliferation|protein kinase C signaling cascade	integral to plasma membrane	angiotensin type II receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	23		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.44e-18)|BRCA - Breast invasive adenocarcinoma(81;5.6e-06)		GACTCCTTTACCTGCTGTACT	0.458000													5	56					0.000602214	0.00065504	1	1	0
GPR107	57720	broad.mit.edu	37	9	132842044	132842044	+	Silent	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:132842044A>T	ENST00000372406.1	+	5	1029	c.522A>T	c.(520-522)acA>acT	p.T174T	GPR107_ENST00000347136.6_Silent_p.T174T|GPR107_ENST00000372410.3_Silent_p.T174T	NM_001136557.1	NP_001130029.1	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107	174						integral to membrane				endometrium(2)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	11		Ovarian(14;0.000531)				CCCAGAAGACACAAGGTAAAC	0.423000													3	42					0	0	1	0	0
WTAP	9589	broad.mit.edu	37	6	160174509	160174509	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:160174509T>C	ENST00000358372.4	+	7	2227	c.470T>C	c.(469-471)tTa>tCa	p.L157S	SOD2_ENST00000546087.1_Intron	NM_001270531.1|NM_004906.4	NP_001257460.1|NP_004897.2	Q15007	FL2D_HUMAN	Wilms tumor 1 associated protein	157					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus				central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	18		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		GGGAAAAAGTTAATGGCGAAG	0.428000													10	41					0	0	1	0	0
MRPS11	64963	broad.mit.edu	37	15	89011140	89011140	+	Splice_Site	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr15:89011140A>T	ENST00000325844.4	+	2	332	c.65_splice	c.e2-1	p.R23_splice	MRPS11_ENST00000557974.1_3'UTR|MRPS11_ENST00000353598.6_Splice_Site_p.R23_splice	NM_022839.3	NP_073750.2	P82912	RT11_HUMAN	mitochondrial ribosomal protein S11	23					DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	structural constituent of ribosome			large_intestine(3)	3	Lung NSC(78;0.203)		BRCA - Breast invasive adenocarcinoma(143;0.188)			TCTTCCCAGCAGGGTCGTGGC	0.652000													5	29					0	0	1	0	0
WDR19	57728	broad.mit.edu	37	4	39217615	39217615	+	Silent	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:39217615A>T	ENST00000399820.3	+	11	1270	c.1116A>T	c.(1114-1116)gtA>gtT	p.V372V	WDR19_ENST00000506503.1_Silent_p.V372V|WDR19_ENST00000288634.7_Silent_p.V212V	NM_025132.3	NP_079408.3	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	372					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						AAGTCACCGTAGCCAACCCTG	0.383000													4	8					0	0	1	0	0
VSX1	30813	broad.mit.edu	37	20	25059522	25059522	+	Silent	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:25059522A>G	ENST00000376709.4	-	3	833	c.570T>C	c.(568-570)gaT>gaC	p.D190D	VSX1_ENST00000376707.3_Silent_p.D190D|VSX1_ENST00000424574.1_Silent_p.D190D|VSX1_ENST00000451258.1_Silent_p.D190D|VSX1_ENST00000429762.3_Silent_p.D190D|VSX1_ENST00000444511.2_Silent_p.D190D	NM_014588.5	NP_055403.2	Q9NZR4	VSX1_HUMAN	visual system homeobox 1	190					response to stimulus|visual perception	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(3)|lung(2)	6						GGGCATACACATCAGGGTAGT	0.542000													43	139					0	0	1	0	0
ADAM7	8756	broad.mit.edu	37	8	24359005	24359005	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:24359005C>A	ENST00000175238.6	+	20	2207	c.2124C>A	c.(2122-2124)acC>acA	p.T708T	ADAM7_ENST00000380789.1_Silent_p.T708T|RP11-561E1.1_ENST00000519364.1_RNA|ADAM7_ENST00000520720.1_Silent_p.T480T|RP11-624C23.1_ENST00000523578.1_RNA|RP11-624C23.1_ENST00000519689.1_RNA	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	708					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		CTACAGAAACCCTGGGAGTGG	0.373000													33	88					2.24893e-16	3.44754e-16	1	1	0
WDR90	197335	broad.mit.edu	37	16	711452	711452	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:711452C>T	ENST00000549091.1	+	30	3716	c.3624C>T	c.(3622-3624)acC>acT	p.T1208T	WDR90_ENST00000293879.4_Silent_p.T1208T	NM_145294.4	NP_660337.3	Q96KV7	WDR90_HUMAN	WD repeat domain 90	1208										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				ATAGCACCACCGTGCTGGCCC	0.657000													15	103					0	0	1	0	0
PCDHB1	29930	broad.mit.edu	37	5	140432999	140432999	+	Silent	SNP	C	C	T	rs35897841		TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:140432999C>T	ENST00000306549.3	+	1	2021	c.1944C>T	c.(1942-1944)caC>caT	p.H648H		NM_013340.2	NP_037472.2	Q9Y5F3	PCDB1_HUMAN		648	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|liver(1)|lung(13)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	53			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCAGGATCACGGCCAACCAG	0.438000													5	167					0	0	1	0	0
PCDHA1	56147	broad.mit.edu	37	5	140167312	140167312	+	Silent	SNP	G	G	A	rs140952598		TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:140167312G>A	ENST00000504120.2	+	1	1437	c.1437G>A	c.(1435-1437)gcG>gcA	p.A479A	PCDHA1_ENST00000394633.3_Silent_p.A479A|PCDHA1_ENST00000378133.3_Silent_p.A479A	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGTGTCTGCGCGGGACGCGG	0.657000													62	137					0	0	1	0	0
POMT1	10585	broad.mit.edu	37	9	134394271	134394271	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:134394271C>A	ENST00000423007.1	+	15	1855	c.1413C>A	c.(1411-1413)atC>atA	p.I471I	POMT1_ENST00000354713.4_Silent_p.I441I|POMT1_ENST00000341012.7_Silent_p.I417I|POMT1_ENST00000419118.2_Silent_p.I319I|POMT1_ENST00000541219.1_Silent_p.I249I|POMT1_ENST00000404875.2_Silent_p.I354I|POMT1_ENST00000372228.3_Silent_p.I493I|POMT1_ENST00000485278.1_3'UTR|POMT1_ENST00000402686.3_Silent_p.I471I|RP11-334J6.6_ENST00000415423.1_RNA	NM_001136113.1	NP_001129585.1	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1	493	MIR 3.				multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	31		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		AACTGGAGATCGTCGGGGAGA	0.677000													7	113					0.00829132	0.00871291	1	1	0
DNAH9	1770	broad.mit.edu	37	17	11757677	11757677	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:11757677C>G	ENST00000262442.3	+	50	9933	c.9865C>G	c.(9865-9867)Ctg>Gtg	p.L3289V	DNAH9_ENST00000454412.2_Missense_Mutation_p.L3289V	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	3289	Stalk (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GCGCCAGGCACTGAACAAAGC	0.572000													15	56					0	0	1	0	0
ASCC3	10973	broad.mit.edu	37	6	101095196	101095196	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:101095196T>A	ENST00000369162.2	-	21	3728	c.3384A>T	c.(3382-3384)agA>agT	p.R1128S		NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	1128	SEC63 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TTGAAAATTGTCTCAAAGGGC	0.413000													4	42					0	0	1	0	0
PLOD2	5352	broad.mit.edu	37	3	145788611	145788611	+	Nonsense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:145788611G>A	ENST00000282903.5	-	20	2347	c.2170C>T	c.(2170-2172)Cga>Tga	p.R724*	PLOD2_ENST00000461497.1_Nonsense_Mutation_p.R384*|PLOD2_ENST00000360060.3_Nonsense_Mutation_p.R703*|PLOD2_ENST00000494950.1_Nonsense_Mutation_p.R669*|RP11-274H2.2_ENST00000480247.1_RNA	NM_182943.2	NP_891988.1	O00469	PLOD2_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2	703	Fe2OG dioxygenase.				protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(11)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29					Vitamin C(DB00126)	CAGCCTTTTCGTGGTGACTCA	0.373000													3	26					0	0	1	0	0
MOGAT2	80168	broad.mit.edu	37	11	75438612	75438612	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:75438612A>T	ENST00000526712.1	+	2	930	c.157A>T	c.(157-159)Atc>Ttc	p.I53F	MOGAT2_ENST00000198801.5_Missense_Mutation_p.I135F			Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	135					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			NS(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	20	Ovarian(111;0.103)					CTTCCCCGGTATCCGCCCCCA	0.567000													56	166					0	0	1	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125685176	125685176	+	Splice_Site	SNP	A	A	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:125685176A>C	ENST00000371126.1	-	1	1657		c.e1+1			NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1											breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						AAATCTGTGTACCTGGAGTAC	0.532000													7	22					0	0	1	0	0
SEMA5A	9037	broad.mit.edu	37	5	9197415	9197415	+	Splice_Site	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:9197415C>G	ENST00000382496.5	-	10	1598	c.932_splice	c.e10-1	p.V311_splice		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	311	Sema.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						CAATGCTGTTCCTGGGAGCGG	0.617000													21	109					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57176365	57176365	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:57176365C>A	ENST00000537055.2	-	2	433	c.202G>T	c.(202-204)Gct>Tct	p.A68S		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						TGGGTAGCAGCAGGGCTCGAT	0.647000													3	30					0.0215528	0.0224374	1	1	0
AHNAK2	113146	broad.mit.edu	37	14	105415731	105415731	+	Silent	SNP	C	C	T	rs139340205	by1000genomes	TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr14:105415731C>T	ENST00000333244.5	-	7	6176	c.6057G>A	c.(6055-6057)gaG>gaA	p.E2019E	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2019						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TCACGTCGGCCTCCACCTTGG	0.617000													4	171					0	0	1	0	0
NPHS2	7827	broad.mit.edu	37	1	179520514	179520514	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:179520514G>C	ENST00000367615.4	-	8	1014	c.946C>G	c.(946-948)Cct>Gct	p.P316A	AXDND1_ENST00000367618.3_Intron|NPHS2_ENST00000367616.4_Missense_Mutation_p.P248A	NM_014625.2	NP_055440.1	Q9NP85	PODO_HUMAN	nephrosis 2, idiopathic, steroid-resistant (podocin)	316					excretion	integral to plasma membrane	protein binding			NS(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	20						ACGGCAGCAGGGGTGCCTGAC	0.502000													16	83					0	0	1	0	0
NNT	23530	broad.mit.edu	37	5	43659345	43659345	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:43659345G>T	ENST00000264663.5	+	17	2748	c.2527G>T	c.(2527-2529)Ggc>Tgc	p.G843C	NNT_ENST00000512996.2_Missense_Mutation_p.G712C|NNT_ENST00000344920.4_Missense_Mutation_p.G843C	NM_012343.3	NP_036475.3	Q13423	NNTM_HUMAN	nicotinamide nucleotide transhydrogenase	843					tricarboxylic acid cycle	integral to membrane|mitochondrial respiratory chain	NAD binding|NAD(P)+ transhydrogenase (AB-specific) activity|NAD(P)+ transhydrogenase (B-specific) activity|NADP binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(7)|large_intestine(6)|liver(2)|lung(20)|ovary(3)|prostate(2)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(6;2.58e-06)				NADH(DB00157)	CAGCTACTCAGGCTGGGCCCT	0.512000													41	134					2.52991e-16	3.86764e-16	1	1	0
SLFN12L	100506736	broad.mit.edu	37	17	33802349	33802349	+	Nonsense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:33802349G>A	ENST00000260908.7	-	4	1477	c.1360C>T	c.(1360-1362)Caa>Taa	p.Q454*	SLFN12L_ENST00000361112.4_Nonsense_Mutation_p.Q483*|SLFN12L_ENST00000449046.1_Nonsense_Mutation_p.Q485*	NM_001195790.1	NP_001182719.1	Q6IEE8	SN12L_HUMAN	schlafen family member 12-like	486						integral to membrane	ATP binding			breast(1)|endometrium(4)|kidney(5)|large_intestine(2)|lung(3)|ovary(1)	16						TGGTTCTCTTGCAAGCCCAGA	0.448000													8	27					0	0	1	0	0
FCN1	2219	broad.mit.edu	37	9	137801676	137801676	+	Nonsense_Mutation	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:137801676T>A	ENST00000371806.3	-	9	1040	c.949A>T	c.(949-951)Aag>Tag	p.K317*		NM_002003.3	NP_001994.2	O00602	FCN1_HUMAN	ficolin (collagen/fibrinogen domain containing) 1	317	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			endometrium(3)|kidney(3)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	37		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		TCTGACACCTTGTAGCTATAT	0.572000													28	54					0	0	1	0	0
GLCCI1	113263	broad.mit.edu	37	7	8125841	8125841	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:8125841G>A	ENST00000223145.5	+	8	1874	c.1317G>A	c.(1315-1317)tcG>tcA	p.S439S		NM_138426.3	NP_612435.1	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	439								p.S439S(1)		endometrium(4)|large_intestine(4)|lung(13)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	25		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		AGCCTATCTCGGCCCCTCTCT	0.388000													34	140					0	0	1	0	0
RAPGEF2	9693	broad.mit.edu	37	4	160263070	160263070	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:160263070G>T	ENST00000264431.4	+	14	2825	c.2406G>T	c.(2404-2406)aaG>aaT	p.K802N		NM_014247.2	NP_055062.1	Q9Y4G8	RPGF2_HUMAN	Rap guanine nucleotide exchange factor (GEF) 2	802	Ras-GEF.				cAMP-mediated signaling|MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|Rap GTPase activator activity|Rap guanyl-nucleotide exchange factor activity|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	70	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.0817)		GGGAATGCAAGAATTTTAACT	0.358000													25	120					8.16721e-17	1.25892e-16	1	1	0
CENPF	1063	broad.mit.edu	37	1	214813740	214813740	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:214813740G>T	ENST00000366955.3	+	12	2227	c.2059G>T	c.(2059-2061)Gac>Tac	p.D687Y		NM_016343.3	NP_057427.3	P49454	CENPF_HUMAN	centromere protein F, 350/400kDa	687					cell differentiation|cell division|cell proliferation|DNA replication|G2 phase of mitotic cell cycle|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		CAACGTGTTAGACAGTAAGTC	0.408000													14	42					1.3612e-06	1.61607e-06	1	1	0
KRT14	3861	broad.mit.edu	37	17	39739564	39739564	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:39739564C>A	ENST00000167586.6	-	6	1283	c.1197G>T	c.(1195-1197)aaG>aaT	p.K399N		NM_000526.4	NP_000517.2	P02533	K1C14_HUMAN	keratin 14	399	Coil 2.|Rod.				epidermis development|hemidesmosome assembly|intermediate filament bundle assembly	cytosol|keratin filament|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(3)|lung(7)|ovary(1)|prostate(5)|skin(1)|stomach(1)	25		Breast(137;0.000307)				CCAGCAGGATCTTGTACTCCT	0.642000													27	77					5.45727e-16	8.25246e-16	1	1	0
ANKRD12	23253	broad.mit.edu	37	18	9258529	9258529	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr18:9258529C>G	ENST00000383440.2	+	8	5452	c.5195C>G	c.(5194-5196)aCa>aGa	p.T1732R	ANKRD12_ENST00000400020.3_Missense_Mutation_p.T1732R|ANKRD12_ENST00000262126.3_Missense_Mutation_p.T1755R	NM_001083625.2	NP_001077094.1	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12	1755						nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						GCTAGCTGTACACTATTATCA	0.368000													7	27					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70859924	70859924	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:70859924C>A	ENST00000322773.4	+	30	2126	c.2024C>A	c.(2023-2025)cCc>cAc	p.P675H	COL19A1_ENST00000393344.1_Missense_Mutation_p.P297H	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	675	Triple-helical region 3 (COL3).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						CTGCCAGGCCCCCCAGGTGAC	0.488000													16	113					7.45023e-12	1.04453e-11	1	1	0
LTBP1	4052	broad.mit.edu	37	2	33477850	33477850	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:33477850C>A	ENST00000404816.2	+	11	2459	c.2106C>A	c.(2104-2106)tgC>tgA	p.C702*	LTBP1_ENST00000354476.3_Nonsense_Mutation_p.C702*|LTBP1_ENST00000402934.1_Nonsense_Mutation_p.C376*|LTBP1_ENST00000407925.1_Nonsense_Mutation_p.C376*|LTBP1_ENST00000390003.4_Nonsense_Mutation_p.C376*|LTBP1_ENST00000404525.1_Nonsense_Mutation_p.C376*|LTBP1_ENST00000418533.2_Nonsense_Mutation_p.C376*			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	702	TB 2.				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				AGCAGCTCTGCTGTTGTAGTG	0.552000													50	143					3.07002e-29	5.25481e-29	1	1	0
IQUB	154865	broad.mit.edu	37	7	123097558	123097558	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:123097558G>A	ENST00000466202.1	-	12	2646	c.2070C>T	c.(2068-2070)tgC>tgT	p.C690C	RP11-332K15.1_ENST00000419832.1_RNA|IQUB_ENST00000324698.6_Silent_p.C690C			Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	690										breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(18)|ovary(3)|prostate(2)|stomach(3)|upper_aerodigestive_tract(1)	45						TGAGATTGTCGCAAGCACTGA	0.458000													11	317					0	0	1	0	0
SIGLEC5	8778	broad.mit.edu	37	19	52130939	52130939	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:52130939C>G	ENST00000222107.4	-	6	1196	c.1058G>C	c.(1057-1059)tGc>tCc	p.C353S	SIGLEC5_ENST00000534261.2_Missense_Mutation_p.C353S|SIGLEC5_ENST00000599649.1_Missense_Mutation_p.C353S|SIGLEC5_ENST00000429354.3_Missense_Mutation_p.C353S|SIGLEC5_ENST00000570106.2_Missense_Mutation_p.C353S			O15389	SIGL5_HUMAN	sialic acid binding Ig-like lectin 5	353					cell adhesion	integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|large_intestine(4)|lung(9)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	27		all_neural(266;0.0726)		GBM - Glioblastoma multiforme(134;0.00124)|OV - Ovarian serous cystadenocarcinoma(262;0.0218)		TCGAAAGGAGCATCTGCAGTG	0.667000													5	13					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33565039	33565039	+	Missense_Mutation	SNP	T	T	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:33565039T>G	ENST00000321505.4	+	1	1219	c.1039T>G	c.(1039-1041)Ttt>Gtt	p.F347V	KIAA1549L_ENST00000265654.5_Missense_Mutation_p.F347V|KIAA1549L_ENST00000389726.3_Missense_Mutation_p.F347V					KIAA1549-like																		ATCTCTTGGCTTTTCCAGCAC	0.532000											OREG0020868	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	147					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10942712	10942712	+	Splice_Site	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr21:10942712T>A	ENST00000298232.7	-	12	1042	c.676_splice	c.e12+1	p.T225_splice	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Splice_Site_p.T205_splice|TPTE_ENST00000361285.4_Splice_Site_p.T243_splice	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	243					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTCACAAACCTGTAACGTAAG	0.333000													75	499					0	0	1	0	0
DVL2	1856	broad.mit.edu	37	17	7137472	7137472	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:7137472C>A	ENST00000005340.5	-	1	392	c.110G>T	c.(109-111)cGc>cTc	p.R37L	DVL2_ENST00000575458.1_Missense_Mutation_p.R37L	NM_004422.2	NP_004413.1	O14641	DVL2_HUMAN	dishevelled segment polarity protein 2	37	DIX.				canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(7)|skin(1)	25						GAGGGTGATGCGCTCGGCGGG	0.602000													56	198					1.42676e-28	2.43466e-28	1	1	0
HMCN1	83872	broad.mit.edu	37	1	186062343	186062343	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:186062343C>A	ENST00000271588.4	+	65	10194	c.9965C>A	c.(9964-9966)aCt>aAt	p.T3322N	HMCN1_ENST00000367492.2_Missense_Mutation_p.T3322N	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3322	Ig-like C2-type 31.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TGTGTTGCTACTAATCCCGCT	0.398000													10	130					3.07112e-06	3.60775e-06	1	1	0
CTC1	80169	broad.mit.edu	37	17	8139594	8139594	+	Nonsense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:8139594G>A	ENST00000315684.8	-	6	866	c.859C>T	c.(859-861)Cga>Tga	p.R287*	CTC1_ENST00000581671.1_5'UTR	NM_025099.5	NP_079375.3	Q2NKJ3	CTC1_HUMAN	CTS telomere maintenance complex component 1	287					positive regulation of DNA replication|telomere maintenance	Stn1-Ten1 complex	protein binding|single-stranded DNA binding			NS(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(8)|ovary(1)|skin(4)	29						TTGGACACTCGCAGTTCTGTC	0.572000													7	61					0	0	1	0	0
KLHL1	57626	broad.mit.edu	37	13	70681609	70681609	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr13:70681609A>T	ENST00000377844.4	-	1	982	c.223T>A	c.(223-225)Tct>Act	p.S75T	ATXN8OS_ENST00000414504.2_RNA|KLHL1_ENST00000545028.1_5'UTR	NM_020866.2	NP_065917.1	Q9NR64	KLHL1_HUMAN	kelch-like family member 1	75	Ser-rich.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(56)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		gaagaggaagaggaggaagGC	0.592000													19	58					0	0	1	0	0
CLTCL1	8218	broad.mit.edu	37	22	19183810	19183810	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr22:19183810C>A	ENST00000263200.10	-	26	4230	c.4158G>T	c.(4156-4158)tgG>tgT	p.W1386C	CLTCL1_ENST00000353891.5_Missense_Mutation_p.W1386C|CLTCL1_ENST00000442042.2_5'UTR|CLTCL1_ENST00000427926.1_Missense_Mutation_p.W1386C	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	1386	Heavy chain arm.|Involved in binding clathrin light chain (By similarity).|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					GACCCTCCTTCCAGGCCTCAG	0.567000			T	?	ALCL								7	50					3.09899e-07	3.74293e-07	1	1	0
SPTA1	6708	broad.mit.edu	37	1	158632582	158632582	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:158632582G>C	ENST00000368148.3	-	17	2554	c.2374C>G	c.(2374-2376)Ctt>Gtt	p.L792V	SPTA1_ENST00000368147.3_Missense_Mutation_p.L792V	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	792					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					AGATGGAGAAGGTCTAAGAGC	0.493000													5	60					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215931992	215931992	+	Silent	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:215931992T>A	ENST00000366943.2	-	58	11720	c.11334A>T	c.(11332-11334)ccA>ccT	p.P3778P	USH2A_ENST00000307340.3_Silent_p.P3778P			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3778	Fibronectin type-III 23.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGATATTATATGGAGGATAGA	0.353000										HNSCC(13;0.011)			26	77					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3000087	3000087	+	Silent	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:3000087C>G	ENST00000520002.1	-	42	6699	c.6144G>C	c.(6142-6144)acG>acC	p.T2048T	CSMD1_ENST00000602723.1_Silent_p.T2048T|CSMD1_ENST00000400186.3_Silent_p.T2048T|CSMD1_ENST00000602557.1_Silent_p.T2048T|CSMD1_ENST00000542608.1_Silent_p.T2047T|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000539096.1_Silent_p.T2047T|CSMD1_ENST00000537824.1_Silent_p.T2047T			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2048	CUB 12.					integral to membrane		p.T1534T(1)		breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CGGGGAGATCCGTGCCGCTAA	0.458000													7	59					0	0	1	0	0
KLHL15	80311	broad.mit.edu	37	X	24024448	24024448	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:24024448G>A	ENST00000328046.8	-	3	618	c.363C>T	c.(361-363)tgC>tgT	p.C121C		NM_030624.2	NP_085127.2	Q96M94	KLH15_HUMAN	kelch-like family member 15	121										autonomic_ganglia(1)|breast(1)|endometrium(8)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)	22						AGAGAAAAGAGCAGCAGAACT	0.403000													19	34					0	0	1	0	0
ABL1	25	broad.mit.edu	37	9	133738212	133738212	+	Silent	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:133738212G>C	ENST00000318560.5	+	4	993	c.612G>C	c.(610-612)acG>acC	p.T204T		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	204	SH2.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	ATCATTCAACGGTGGCCGACG	0.572000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								38	116					0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26664773	26664773	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:26664773C>G	ENST00000256737.3	+	23	3172	c.2320C>G	c.(2320-2322)Cta>Gta	p.L774V	ANO3_ENST00000525139.1_Missense_Mutation_p.L758V|ANO3_ENST00000531568.1_Missense_Mutation_p.L628V|ANO3_ENST00000537978.1_Missense_Mutation_p.L758V	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	774						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						GGCTTTTCCTCTAGCCCCTCT	0.403000													5	96					0	0	1	0	0
ST6GALNAC6	30815	broad.mit.edu	37	9	130648896	130648896	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:130648896G>A	ENST00000373142.1	-	7	1152	c.980C>T	c.(979-981)cCc>cTc	p.P327L	ST6GALNAC6_ENST00000542456.1_Silent_p.S128S|ST6GALNAC6_ENST00000373141.1_Silent_p.S294S|ST6GALNAC6_ENST00000373146.1_Silent_p.S328S|RP11-203J24.9_ENST00000476274.2_RNA|ST6GALNAC6_ENST00000373144.3_Silent_p.S294S|ST6GALNAC6_ENST00000485320.1_5'UTR|ST6GALNAC6_ENST00000291839.5_Silent_p.S328S	NM_013443.3	NP_038471.2	Q969X2	SIA7F_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	14					protein glycosylation	integral to Golgi membrane|plasma membrane				endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						AGGAGGGGTGGGAGAAGGTGA	0.617000													27	67					0	0	1	0	0
NDUFB8	4714	broad.mit.edu	37	10	102286806	102286806	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:102286806C>A	ENST00000557395.1	-	3	267	c.238G>T	c.(238-240)Gac>Tac	p.D80Y	NDUFB8_ENST00000299166.4_Missense_Mutation_p.D80Y|NDUFB8_ENST00000370322.1_Missense_Mutation_p.D49Y|SEC31B_ENST00000535773.1_5'UTR|NDUFB8_ENST00000370320.4_Missense_Mutation_p.D80Y|NDUFB8_ENST00000531258.1_Missense_Mutation_p.D80Y			O95169	NDUB8_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	80					mitochondrial electron transport, NADH to ubiquinone|transport	endoplasmic reticulum|integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			endometrium(2)|lung(2)	4		Colorectal(252;0.234)		Epithelial(162;5.68e-10)|all cancers(201;4.05e-08)	NADH(DB00157)	TGTGAGCGGTCAGGGAGCTTC	0.517000													10	54					1.08611e-07	1.34977e-07	1	1	0
KIF21B	23046	broad.mit.edu	37	1	200968555	200968555	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:200968555C>A	ENST00000332129.2	-	13	2123	c.1807G>T	c.(1807-1809)Gaa>Taa	p.E603*	KIF21B_ENST00000360529.5_Nonsense_Mutation_p.E603*|KIF21B_ENST00000461742.2_Nonsense_Mutation_p.E603*|KIF21B_ENST00000422435.2_Nonsense_Mutation_p.E603*	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	603					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						TCGCGCCCTTCCTCCTCCTCA	0.647000													40	130					5.20006e-24	8.71362e-24	1	1	0
COL5A1	1289	broad.mit.edu	37	9	137703220	137703220	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:137703220C>T	ENST00000371817.3	+	45	3978	c.3564C>T	c.(3562-3564)atC>atT	p.I1188I		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	1188	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AAGGCCCCATCGGACAGCCAG	0.607000											OREG0019605	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	61	177					0	0	1	0	0
SHE	126669	broad.mit.edu	37	1	154458442	154458442	+	Silent	SNP	G	G	A	rs78067230	byFrequency	TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:154458442G>A	ENST00000304760.2	-	5	1364	c.1278C>T	c.(1276-1278)aaC>aaT	p.N426N		NM_001010846.2	NP_001010846.1	Q5VZ18	SHE_HUMAN	Src homology 2 domain containing E	426	SH2.									breast(4)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(2)|pancreas(1)	14	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGTACCTGCTGTTCCCTGACT	0.493000													13	48					0	0	1	0	0
INTS10	55174	broad.mit.edu	37	8	19682462	19682462	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:19682462A>T	ENST00000397977.3	+	8	1383	c.985A>T	c.(985-987)Ata>Tta	p.I329L		NM_018142.2	NP_060612.2	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	329					snRNA processing	integrator complex	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	20				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		TGTCAACAGCATACAGCCATC	0.383000													23	62					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576395	158576395	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:158576395A>T	ENST00000361284.1	+	1	167	c.167A>T	c.(166-168)cAc>cTc	p.H56L		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	56					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					AGCCATCTGCACACCCCCATG	0.512000													79	305					0	0	1	0	0
MRGPRX4	117196	broad.mit.edu	37	11	18195060	18195060	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:18195060G>T	ENST00000314254.3	+	1	677	c.257G>T	c.(256-258)cGc>cTc	p.R86L	RP11-113D6.6_ENST00000527671.1_Intron	NM_054032.3	NP_473373.2	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	86						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						TTGCCATTACGCCTCATCAAT	0.522000													21	49					1.2644e-06	1.50434e-06	1	1	0
TPH2	121278	broad.mit.edu	37	12	72338365	72338365	+	Splice_Site	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:72338365G>T	ENST00000333850.3	+	4	580		c.e4-1		TPH2_ENST00000546576.1_Splice_Site	NM_173353.3	NP_775489.2	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2						aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	41					L-Tryptophan(DB00150)	GTTTTCAACAGAGCTAGAGGA	0.438000													40	86					1.06522e-23	1.77962e-23	1	1	0
DPH2	1802	broad.mit.edu	37	1	44435873	44435873	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:44435873C>G	ENST00000255108.3	+	1	198	c.26C>G	c.(25-27)gCc>gGc	p.A9G	DPH2_ENST00000412950.2_5'UTR|DPH2_ENST00000396758.2_Missense_Mutation_p.A9G|DPH2_ENST00000529729.1_3'UTR	NM_001384.4	NP_001375.2	Q9BQC3	DPH2_HUMAN	DPH2 homolog (S. cerevisiae)	9					peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm				autonomic_ganglia(1)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(2)|skin(1)	19	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				AGCAGCCCTGCCGAGGCGGCG	0.642000													13	74					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32913113	32913113	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr13:32913113A>G	ENST00000544455.1	+	11	4848	c.4621A>G	c.(4621-4623)Aaa>Gaa	p.K1541E	BRCA2_ENST00000380152.3_Missense_Mutation_p.K1541E	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	1541					cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		ATCTTTGGACAAAGTGAAAAA	0.393000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			10	33					0	0	1	0	0
ALG9	79796	broad.mit.edu	37	11	111747582	111747582	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:111747582C>A	ENST00000524880.1	-	3	775	c.483G>T	c.(481-483)gtG>gtT	p.V161V	FDXACB1_ENST00000542429.1_Silent_p.V12V|FDXACB1_ENST00000260257.4_Silent_p.V161V			Q9H6U8	ALG9_HUMAN	ALG9, alpha-1,2-mannosyltransferase	0					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		TGAATGGATACACGTCGCTTA	0.507000													10	35					1.5739e-10	2.12134e-10	1	1	0
ZG16B	124220	broad.mit.edu	37	16	2882003	2882003	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:2882003C>A	ENST00000382280.3	+	4	549	c.470C>A	c.(469-471)cCc>cAc	p.P157H	ZG16B_ENST00000572863.1_Missense_Mutation_p.P127H	NM_145252.2	NP_660295.2	Q96DA0	ZG16B_HUMAN	zymogen granule protein 16B	157						extracellular region	sugar binding			central_nervous_system(1)|lung(2)|ovary(1)|prostate(1)	5						TCTGCCTACCCCAGCCAAGAG	0.532000													12	82					1.5842e-08	2.02285e-08	1	1	0
COL14A1	7373	broad.mit.edu	37	8	121357762	121357762	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:121357762C>T	ENST00000297848.3	+	45	5307	c.5037C>T	c.(5035-5037)ttC>ttT	p.F1679F	COL14A1_ENST00000309791.4_Silent_p.F1679F|COL14A1_ENST00000247781.3_Silent_p.F1584F	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1679	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CACCAGGCTTCCCCGGAAATG	0.642000													7	34					0	0	1	0	0
PADI2	11240	broad.mit.edu	37	1	17395760	17395760	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:17395760C>T	ENST00000375486.4	-	16	1840	c.1777G>A	c.(1777-1779)Gtg>Atg	p.V593M	PADI2_ENST00000466151.1_5'UTR|PADI2_ENST00000444885.2_Missense_Mutation_p.V477M	NM_007365.2	NP_031391.2	Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	593					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	TTGTCCAGCACGATCATGTTC	0.582000													9	46					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169122808	169122808	+	Splice_Site	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:169122808A>T	ENST00000256935.8	+	10	925	c.843_splice	c.e10-1	p.D282_splice		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	282					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCCCCCAGGATCTTGGAAAC	0.398000													6	114					0	0	1	0	0
GRM1	2911	broad.mit.edu	37	6	146480589	146480589	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:146480589G>C	ENST00000392299.2	+	3	1276	c.806G>C	c.(805-807)aGc>aCc	p.S269T	GRM1_ENST00000492807.2_Missense_Mutation_p.S269T|GRM1_ENST00000282753.1_Missense_Mutation_p.S269T|GRM1_ENST00000355289.4_Missense_Mutation_p.S269T|GRM1_ENST00000507907.1_Missense_Mutation_p.S269T|GRM1_ENST00000361719.2_Missense_Mutation_p.S269T			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	269					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GGGGAGAAGAGCTTTGACCGA	0.562000													4	32					0	0	1	0	0
TEAD4	7004	broad.mit.edu	37	12	3126660	3126660	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:3126660G>T	ENST00000359864.2	+	6	641	c.451G>T	c.(451-453)Gcc>Tcc	p.A151S	TEAD4_ENST00000397122.2_Missense_Mutation_p.A22S|TEAD4_ENST00000358409.2_Intron	NM_003213.3	NP_003204.2	Q15561	TEAD4_HUMAN	TEA domain family member 4	151					hippo signaling cascade|muscle organ development|skeletal system development		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	10	Ovarian(42;0.211)		OV - Ovarian serous cystadenocarcinoma(31;0.000563)|COAD - Colon adenocarcinoma(12;0.0831)			CATGGCCCTcgcccggggccc	0.667000													8	36					0.000157383	0.000174246	1	1	0
ARHGEF11	9826	broad.mit.edu	37	1	156917203	156917203	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:156917203C>T	ENST00000368194.3	-	26	3420	c.2381G>A	c.(2380-2382)cGg>cAg	p.R794Q	ARHGEF11_ENST00000315174.8_Missense_Mutation_p.R170Q|ARHGEF11_ENST00000361409.2_Missense_Mutation_p.R754Q	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	754	DH.				actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GTCCAGGACCCGGAGTGTGCG	0.567000													9	33					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31302387	31302387	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:31302387G>T	ENST00000265071.2	+	6	1246	c.981G>T	c.(979-981)ggG>ggT	p.G327G	CDH6_ENST00000514738.1_Silent_p.G272G	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	327	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CCCAGGAAGGGATTATAACTG	0.438000													21	74					1.5548e-18	2.46471e-18	1	1	0
PCDH11X	27328	broad.mit.edu	37	X	91134012	91134012	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:91134012C>A	ENST00000373094.1	+	2	3618	c.2773C>A	c.(2773-2775)Cct>Act	p.P925T	PCDH11X_ENST00000406881.1_Missense_Mutation_p.P925T|PCDH11X_ENST00000373097.1_Missense_Mutation_p.P925T|PCDH11X_ENST00000395337.2_Missense_Mutation_p.P925T|PCDH11X_ENST00000361655.2_Missense_Mutation_p.P925T|PCDH11X_ENST00000504220.1_Missense_Mutation_p.P925T|PCDH11X_ENST00000361724.1_Missense_Mutation_p.P925T|PCDH11X_ENST00000373088.1_Missense_Mutation_p.P925T|PCDH11X_ENST00000298274.8_Missense_Mutation_p.P925T	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	925					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						GGTAACTACACCTACTACTTT	0.463000													24	118					4.87955e-14	7.12773e-14	1	1	0
MPO	4353	broad.mit.edu	37	17	56357807	56357807	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:56357807C>T	ENST00000340482.3	-	2	344	c.168G>A	c.(166-168)gaG>gaA	p.E56E	MPO_ENST00000225275.3_Silent_p.E56E			P05164	PERM_HUMAN	myeloperoxidase	56					anti-apoptosis|hydrogen peroxide catabolic process|low-density lipoprotein particle remodeling	extracellular space|lysosome|nucleus|stored secretory granule	chromatin binding|heme binding|heparin binding|peroxidase activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(13)|ovary(2)|pancreas(1)|skin(4)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	46					Cefdinir(DB00535)	AGGTGTCCACCTCCCCCAGGA	0.632000													13	36					0	0	1	0	0
PGS1	9489	broad.mit.edu	37	17	76392437	76392437	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:76392437C>T	ENST00000262764.6	+	3	408	c.382C>T	c.(382-384)Ctg>Ttg	p.L128L	PGS1_ENST00000329897.7_Intron	NM_024419.3	NP_077733.3	Q32NB8	PGPS1_HUMAN	phosphatidylglycerophosphate synthase 1	128					phospholipid biosynthetic process	endoplasmic reticulum|mitochondrion	ATP binding|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity			cervix(2)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)|urinary_tract(1)	10			BRCA - Breast invasive adenocarcinoma(99;0.00144)|OV - Ovarian serous cystadenocarcinoma(97;0.031)			ATCCCTCTACCTGGGGACAGG	0.488000													19	76					0	0	1	0	0
ASGR1	432	broad.mit.edu	37	17	7077487	7077487	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:7077487G>T	ENST00000574388.1	-	5	1239	c.447C>A	c.(445-447)caC>caA	p.H149Q	ASGR1_ENST00000572879.1_Missense_Mutation_p.H48Q|ASGR1_ENST00000269299.3_Missense_Mutation_p.H188Q|ASGR1_ENST00000380920.4_Missense_Mutation_p.H87Q			P07306	ASGR1_HUMAN	asialoglycoprotein receptor 1	188					receptor-mediated endocytosis	integral to plasma membrane	asialoglycoprotein receptor activity|metal ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|urinary_tract(1)	10						CCACCACCAGGTGCGCGTCCT	0.672000													12	121					4.36969e-10	5.83322e-10	1	1	0
MORC1	27136	broad.mit.edu	37	3	108746644	108746644	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:108746644T>C	ENST00000232603.5	-	17	1740	c.1658A>G	c.(1657-1659)gAg>gGg	p.E553G	MORC1_ENST00000483760.1_Missense_Mutation_p.E553G	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	553					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TATGACCGACTCTCTAAGTTG	0.413000													45	118					0	0	1	0	0
LCP2	3937	broad.mit.edu	37	5	169685154	169685154	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:169685154C>A	ENST00000046794.5	-	16	1602	c.987G>T	c.(985-987)ttG>ttT	p.L329F	LCP2_ENST00000521416.1_Missense_Mutation_p.L124F	NM_005565.3	NP_005556.1	Q13094	LCP2_HUMAN	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	329					immune response|platelet activation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	23	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		CTGGCTGGGGCAAAGGTCTCT	0.502000													12	123					2.87052e-16	4.36444e-16	1	1	0
FNBP4	23360	broad.mit.edu	37	11	47774629	47774629	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:47774629T>A	ENST00000263773.5	-	4	488	c.476A>T	c.(475-477)cAg>cTg	p.Q159L	FNBP4_ENST00000534003.1_5'UTR	NM_015308.2	NP_056123.2	Q8N3X1	FNBP4_HUMAN	formin binding protein 4	159										NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(12)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	44						AGCTGCAGGCTGAGGAGCTGT	0.428000													11	14					0	0	1	0	0
SMAD3	4088	broad.mit.edu	37	15	67482863	67482863	+	Missense_Mutation	SNP	A	A	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr15:67482863A>C	ENST00000327367.4	+	9	1577	c.1267A>C	c.(1267-1269)Agt>Cgt	p.S423R	SMAD3_ENST00000540846.2_Missense_Mutation_p.S318R|SMAD3_ENST00000537194.2_Missense_Mutation_p.S228R|SMAD3_ENST00000439724.3_Missense_Mutation_p.S379R	NM_005902.3	NP_005893.1	P84022	SMAD3_HUMAN	SMAD family member 3	423	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding	p.S423G(1)		autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(11)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		CCGCTGTTCCAGTGTGTCTTA	0.542000													12	32					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77768504	77768504	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:77768504C>G	ENST00000521891.2	+	10	9795	c.9347C>G	c.(9346-9348)tCc>tGc	p.S3116C	ZFHX4_ENST00000518282.1_Missense_Mutation_p.S3090C|ZFHX4_ENST00000050961.6_Missense_Mutation_p.S3071C|ZFHX4_ENST00000455469.2_Missense_Mutation_p.S3071C	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	3071	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.S3100Y(1)		NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AACGGTCCATCCTCCTTGCCG	0.502000										HNSCC(33;0.089)			21	76					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1653191	1653191	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:1653191G>T	ENST00000252804.4	-	17	2411	c.2361C>A	c.(2359-2361)taC>taA	p.Y787*		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	787					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CGTGCCCGTTGTACAGTCGGT	0.642000													27	79					6.00712e-18	9.46885e-18	1	1	0
ZNF862	643641	broad.mit.edu	37	7	149557742	149557742	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:149557742A>T	ENST00000223210.4	+	7	1738	c.1493A>T	c.(1492-1494)gAt>gTt	p.D498V		NM_001099220.1	NP_001092690.1	O60290	ZN862_HUMAN	zinc finger protein 862	498					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(1)	34						AATCTCCATGATAAATCATCT	0.453000													14	78					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62286994	62286994	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:62286994G>A	ENST00000378024.4	-	5	15169	c.14895C>T	c.(14893-14895)atC>atT	p.I4965I	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	4965					nervous system development	nucleus	protein binding	p.I4965I(2)		NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CTGGCCCTTCGATGTTAATAT	0.453000													15	67					0	0	1	0	0
NAV2	89797	broad.mit.edu	37	11	20065549	20065549	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:20065549A>G	ENST00000396085.1	+	13	3291	c.2930A>G	c.(2929-2931)cAg>cGg	p.Q977R	NAV2_ENST00000540292.1_Missense_Mutation_p.Q931R|NAV2_ENST00000533917.1_Missense_Mutation_p.Q63R|NAV2_ENST00000311043.8_Missense_Mutation_p.Q63R|NAV2_ENST00000360655.4_Missense_Mutation_p.Q913R|NAV2_ENST00000396087.3_Missense_Mutation_p.Q1000R|NAV2_ENST00000349880.4_Missense_Mutation_p.Q977R|NAV2-AS2_ENST00000533767.1_RNA|NAV2_ENST00000527559.2_Missense_Mutation_p.Q929R	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	1000						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						AAGCACTCACAGGTGGAGAGG	0.537000													3	128					0	0	1	0	0
CDH20	28316	broad.mit.edu	37	18	59217332	59217332	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr18:59217332G>T	ENST00000262717.4	+	11	2168	c.1770G>T	c.(1768-1770)ctG>ctT	p.L590L	CDH20_ENST00000536675.2_Silent_p.L590L|CDH20_ENST00000538374.1_Silent_p.L590L			Q9HBT6	CAD20_HUMAN	cadherin 20, type 2	590	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|skin(3)	61		Colorectal(73;0.186)				CAGGCACACTGACCATCCAAG	0.607000													15	36					1.15088e-07	1.42077e-07	1	1	0
FAM83B	222584	broad.mit.edu	37	6	54805921	54805921	+	Nonsense_Mutation	SNP	G	G	T	rs143165363	byFrequency	TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:54805921G>T	ENST00000306858.7	+	5	2268	c.2152G>T	c.(2152-2154)Gag>Tag	p.E718*		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	718										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TCATAACTTGGAGGAGGATGA	0.398000													13	85					4.93089e-13	7.05497e-13	1	1	0
DUS3L	56931	broad.mit.edu	37	19	5787307	5787307	+	Splice_Site	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:5787307C>A	ENST00000309061.7	-	7	1374	c.1278_splice	c.e7+1	p.Q426_splice	DUS3L_ENST00000320699.8_Splice_Site_p.Q184_splice	NM_020175.2	NP_064560.2	Q96G46	DUS3L_HUMAN	dihydrouridine synthase 3-like (S. cerevisiae)	426					tRNA processing		flavin adenine dinucleotide binding|nucleic acid binding|tRNA dihydrouridine synthase activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(2)	14						CTGGCCGTACCTGGTTCATGC	0.652000													18	36					5.03518e-11	6.88635e-11	1	1	0
SLC38A7	55238	broad.mit.edu	37	16	58705100	58705100	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:58705100C>T	ENST00000570101.1	-	9	1963	c.1080G>A	c.(1078-1080)gaG>gaA	p.E360E	SLC38A7_ENST00000564010.1_Silent_p.E271E|SLC38A7_ENST00000219320.4_Silent_p.E360E|SLC38A7_ENST00000566953.1_Intron|SLC38A7_ENST00000564100.1_Intron			Q9NVC3	S38A7_HUMAN	solute carrier family 38, member 7	360					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|large_intestine(2)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	13						CCACGTCCTCCTCCACTGGCA	0.682000													9	84					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34079134	34079134	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:34079134C>T	ENST00000397527.1	+	22	3571	c.2851C>T	c.(2851-2853)Ctg>Ttg	p.L951L	CEP250_ENST00000342580.4_Silent_p.L895L	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	951	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			ACTGGAACGACTGAGGCAGGA	0.522000													4	12					0	0	1	0	0
BPI	671	broad.mit.edu	37	20	36952396	36952396	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:36952396G>T	ENST00000262865.4	+	8	982	c.893G>T	c.(892-894)gGg>gTg	p.G298V	BPI_ENST00000489102.1_3'UTR|CTD-2308N23.2_ENST00000437016.1_RNA	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	298					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				AACACAGCCGGGCTTGTATAC	0.557000													12	39					0.000151284	0.000168161	1	1	0
FAM91A1	157769	broad.mit.edu	37	8	124787436	124787436	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:124787436G>C	ENST00000334705.7	+	3	453	c.207G>C	c.(205-207)aaG>aaC	p.K69N	FAM91A1_ENST00000521166.1_Missense_Mutation_p.K69N	NM_144963.2	NP_659400.2	Q658Y4	F91A1_HUMAN	family with sequence similarity 91, member A1	69										breast(4)|central_nervous_system(3)|endometrium(6)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			AACTGCTAAAGTACAGCCGAG	0.373000													3	73					0	0	1	0	0
SF1	7536	broad.mit.edu	37	11	64536951	64536951	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:64536951G>A	ENST00000377390.3	-	6	947	c.610C>T	c.(610-612)Cat>Tat	p.H204Y	SF1_ENST00000227503.9_Missense_Mutation_p.H204Y|SF1_ENST00000334944.5_Missense_Mutation_p.H204Y|SF1_ENST00000422298.2_Missense_Mutation_p.H89Y|SF1_ENST00000433274.2_Missense_Mutation_p.H178Y|SF1_ENST00000377387.1_Missense_Mutation_p.H329Y|SF1_ENST00000377394.3_Missense_Mutation_p.H204Y|SF1_ENST00000489544.1_5'UTR	NM_004630.3	NP_004621.2	Q15637	SF01_HUMAN	splicing factor 1	204	KH.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	31						ACCAGGGCATGAAGTGGCTCA	0.522000													83	167					0	0	1	0	0
CXCR3	2833	broad.mit.edu	37	X	70836379	70836379	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:70836379G>A	ENST00000373691.4	-	2	1247	c.1084C>T	c.(1084-1086)Ccg>Tcg	p.P362S	CXCR3_ENST00000373693.3_Missense_Mutation_p.P315S	NM_001142797.1	NP_001136269.1	P49682	CXCR3_HUMAN	chemokine (C-X-C motif) receptor 3	315					cell adhesion|cellular component movement|chemotaxis|elevation of cytosolic calcium ion concentration	cytoplasm|integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|central_nervous_system(2)|large_intestine(2)|lung(3)|ovary(2)	10	Renal(35;0.156)					TAGAGCAGCGGGTTGAGGCAG	0.642000													3	55					0	0	1	0	0
KIAA0947	23379	broad.mit.edu	37	5	5460782	5460782	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:5460782C>T	ENST00000296564.7	+	13	1557	c.1335C>T	c.(1333-1335)ttC>ttT	p.F445F		NM_015325.2	NP_056140.1	Q9Y2F5	K0947_HUMAN	KIAA0947	445										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)	35						TCGAGACTTTCACAGCAACAC	0.433000													6	34					0	0	1	0	0
FEM1B	10116	broad.mit.edu	37	15	68583191	68583191	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr15:68583191G>A	ENST00000306917.4	+	2	2110	c.1495G>A	c.(1495-1497)Gat>Aat	p.D499N		NM_015322.3	NP_056137.1	Q9UK73	FEM1B_HUMAN	fem-1 homolog b (C. elegans)	499					apoptosis|induction of apoptosis|regulation of DNA damage checkpoint|regulation of ubiquitin-protein ligase activity	cytoplasm|nucleus	death receptor binding|ubiquitin-protein ligase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	9						TACTCCAGTTGATGATTTCCA	0.473000													49	133					0	0	1	0	0
CENPN	55839	broad.mit.edu	37	16	81056210	81056210	+	Silent	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:81056210A>T	ENST00000305850.5	+	7	1330	c.540A>T	c.(538-540)acA>acT	p.T180T	CENPN_ENST00000439957.3_Silent_p.T160T|CENPN_ENST00000428963.2_Intron|CENPN_ENST00000393335.3_Silent_p.T180T|CENPN_ENST00000299572.5_Intron|RP11-303E16.3_ENST00000562315.1_RNA	NM_001100624.2|NM_001270474.1	NP_001094094.2|NP_001257403.1	Q96H22	CENPN_HUMAN	centromere protein N	180					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm				breast(1)|large_intestine(5)|lung(4)	10						AGGCGCTGACAATTGCTAGCA	0.378000													9	49					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51960979	51960979	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:51960979G>T	ENST00000321424.3	-	2	535	c.469C>A	c.(469-471)Cct>Act	p.P157T	SIGLEC8_ENST00000430817.1_Intron|SIGLEC8_ENST00000340550.5_Intron	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	157	Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		AGGATGTCAGGCCTATGGGTC	0.607000													20	137					4.26978e-12	6.03174e-12	1	1	0
SDK1	221935	broad.mit.edu	37	7	4272965	4272965	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:4272965G>T	ENST00000404826.2	+	41	6045	c.5906G>T	c.(5905-5907)cGg>cTg	p.R1969L	SDK1_ENST00000466611.1_3'UTR|SDK1_ENST00000389531.3_Missense_Mutation_p.R1949L	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1969	Fibronectin type-III 13.				cell adhesion	integral to membrane		p.R1969Q(1)		NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		GATAAGCTCCGGCAAGGAGTG	0.617000													53	108					2.69953e-25	4.55088e-25	1	1	0
NLRP1	22861	broad.mit.edu	37	17	5421149	5421149	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:5421149A>G	ENST00000345221.3	-	14	4396	c.3842T>C	c.(3841-3843)gTt>gCt	p.V1281A	NLRP1_ENST00000572272.1_Missense_Mutation_p.V1325A|NLRP1_ENST00000354411.3_Missense_Mutation_p.V1295A|NLRP1_ENST00000577119.1_Missense_Mutation_p.V1251A|NLRP1_ENST00000262467.5_Missense_Mutation_p.V1329A|NLRP1_ENST00000269280.4_Missense_Mutation_p.V1281A	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1	1325					defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				CAAGTGGCCAACGTAGAACTC	0.512000													19	60					0	0	1	0	0
AVPR1A	552	broad.mit.edu	37	12	63543820	63543820	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:63543820A>G	ENST00000299178.2	-	1	902	c.797T>C	c.(796-798)tTc>tCc	p.F266S		NM_000706.4	NP_000697.1	P37288	V1AR_HUMAN	arginine vasopressin receptor 1A	266					activation of phospholipase C activity|elevation of cytosolic calcium ion concentration|generation of precursor metabolites and energy	endosome|integral to plasma membrane	protein kinase C binding|vasopressin receptor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(12)|prostate(2)|skin(1)	26			BRCA - Breast invasive adenocarcinoma(9;0.193)	GBM - Glioblastoma multiforme(28;0.0569)	Conivaptan(DB00872)|Desmopressin(DB00035)|Felypressin(DB00093)|Terlipressin(DB02638)|Vasopressin(DB00067)	CCCCTTTTGGAAGGCCACACC	0.597000													58	185					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3417646	3417646	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:3417646C>A	ENST00000356575.4	-	20	2685	c.2459G>T	c.(2458-2460)gGc>gTc	p.G820V	MEGF6_ENST00000294599.4_Missense_Mutation_p.G715V	NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	820						extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		ACCATACCAGCCTGCTGGGCA	0.662000													12	76					1.52009e-12	2.1638e-12	1	1	0
SOCS5	9655	broad.mit.edu	37	2	46986645	46986645	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:46986645G>T	ENST00000306503.5	+	2	1148	c.976G>T	c.(976-978)Gag>Tag	p.E326*	SOCS5_ENST00000394861.2_Nonsense_Mutation_p.E326*	NM_014011.4	NP_054730.1	O75159	SOCS5_HUMAN	suppressor of cytokine signaling 5	326					cell growth|cytokine-mediated signaling pathway|intracellular signal transduction|negative regulation of signal transduction|negative regulation of T-helper 2 cell differentiation|positive regulation of T-helper 1 cell differentiation|regulation of growth					breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(9)|ovary(2)	22		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			TGACTCGGAAGAGGATACAAC	0.463000													29	80					1.06801e-11	1.48616e-11	1	1	0
SHB	6461	broad.mit.edu	37	9	37974719	37974719	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:37974719G>A	ENST00000377707.3	-	3	1519	c.954C>T	c.(952-954)ccC>ccT	p.P318P	RP11-613M10.9_ENST00000540557.1_3'UTR	NM_003028.2	NP_003019.2	Q15464	SHB_HUMAN	Src homology 2 domain containing adaptor protein B	318	Mediates interaction with LAT, FAK1, JAK1 and JAK3.				angiogenesis|apoptosis|cell differentiation|signal transduction	cytoplasm|plasma membrane	SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(4)|lung(1)|prostate(1)|skin(1)|soft_tissue(1)|stomach(1)	11		all_epithelial(88;0.122)		GBM - Glioblastoma multiforme(29;3.27e-05)|Lung(182;0.0658)		CCCGCAGTCGGGGGCTGACTG	0.592000													31	79					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73179476	73179476	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:73179476C>A	ENST00000286657.4	-	12	1699	c.1663G>T	c.(1663-1665)Ggg>Tgg	p.G555W		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	555	TSP type-1 1.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GTCCATGACCCCCAATTGCCA	0.403000													7	61					5.18039e-06	6.02221e-06	1	1	0
POTEH	23784	broad.mit.edu	37	22	16267015	16267015	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr22:16267015A>T	ENST00000343518.6	-	9	1485	c.1434T>A	c.(1432-1434)aaT>aaA	p.N478K		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	478										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						CATCATCACCATTGTCAGCAG	0.423000													17	564					0	0	1	0	0
DUSP10	11221	broad.mit.edu	37	1	221912767	221912767	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:221912767C>G	ENST00000366899.3	-	2	558	c.320G>C	c.(319-321)gGa>gCa	p.G107A	DUSP10_ENST00000323825.3_Intron	NM_007207.4	NP_009138.1	Q9Y6W6	DUS10_HUMAN	dual specificity phosphatase 10	107					inactivation of MAPK activity|JNK cascade|negative regulation of JNK cascade|negative regulation of JUN kinase activity|negative regulation of stress-activated MAPK cascade	Golgi apparatus|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			NS(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36				GBM - Glioblastoma multiforme(131;0.0103)		GGTAGAGGTTCCGATGGCAGT	0.572000													17	36					0	0	1	0	0
DOCK5	80005	broad.mit.edu	37	8	25216507	25216507	+	Missense_Mutation	SNP	T	T	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:25216507T>G	ENST00000276440.7	+	28	2923	c.2879T>G	c.(2878-2880)cTg>cGg	p.L960R		NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	960						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		ATGATTGCCCTGCTGCAGCAA	0.473000													30	84					0	0	1	0	0
RANGAP1	5905	broad.mit.edu	37	22	41642642	41642642	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr22:41642642G>A	ENST00000455915.2	-	15	3198	c.1729C>T	c.(1729-1731)Cgc>Tgc	p.R577C	RANGAP1_ENST00000407260.4_Missense_Mutation_p.R522C|RANGAP1_ENST00000405486.1_Missense_Mutation_p.R577C|RANGAP1_ENST00000356244.3_Missense_Mutation_p.R577C			P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	577					mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						AGACTGTGGCGGGCGAAGGAG	0.622000													2	3					0	0	1	0	0
OR4C3	256144	broad.mit.edu	37	11	48347004	48347004	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:48347004G>A	ENST00000319856.4	+	1	533	c.512G>A	c.(511-513)gGg>gAg	p.G171E		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	144					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						ATGCTTGTAGGGGTGGCTTGG	0.527000													18	67					0	0	1	0	0
TAB1	10454	broad.mit.edu	37	22	39822784	39822784	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr22:39822784G>C	ENST00000216160.6	+	9	1060	c.998G>C	c.(997-999)cGg>cCg	p.R333P	TAB1_ENST00000331454.3_Missense_Mutation_p.R333P	NM_006116.2	NP_006107.1	Q15750	TAB1_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 1	333	PP2C-like.				activation of MAPK activity|activation of MAPKKK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane	catalytic activity|protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|urinary_tract(1)	14						GTCGTGGACCGGGTGAAGCGC	0.632000													29	111					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4848478	4848478	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:4848478A>G	ENST00000252318.2	+	3	996	c.659A>G	c.(658-660)gAt>gGt	p.D220G	RP11-234B24.6_ENST00000544741.2_3'UTR	NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	220	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						ATCTTGGTGGATGATTTCAGC	0.423000													43	59					0	0	1	0	0
OR2D2	120776	broad.mit.edu	37	11	6913209	6913209	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:6913209C>A	ENST00000299459.2	-	1	621	c.523G>T	c.(523-525)Gct>Tct	p.A175S		NM_003700.1	NP_003691.1	Q9H210	OR2D2_HUMAN	olfactory receptor, family 2, subfamily D, member 2	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|skin(2)	18		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AAGAAATGAGCAATGCTGTTA	0.498000													5	44					0.00198382	0.0021247	1	1	0
OR2G2	81470	broad.mit.edu	37	1	247752038	247752038	+	Missense_Mutation	SNP	A	A	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:247752038A>C	ENST00000320065.1	+	1	377	c.377A>C	c.(376-378)tAt>tCt	p.Y126S	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	126					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TGTGACCGCTATGTGGCTGTC	0.532000													103	234					0	0	1	0	0
KIF21B	23046	broad.mit.edu	37	1	200969639	200969639	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:200969639C>T	ENST00000332129.2	-	11	1880	c.1564G>A	c.(1564-1566)Gcc>Acc	p.A522T	KIF21B_ENST00000360529.5_Missense_Mutation_p.A522T|KIF21B_ENST00000461742.2_Missense_Mutation_p.A522T|KIF21B_ENST00000422435.2_Missense_Mutation_p.A522T	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	522					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						GCCGGGGCGGCTGGAGAAGCA	0.652000													29	66					0	0	1	0	0
OR2T2	401992	broad.mit.edu	37	1	248617046	248617046	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:248617046G>T	ENST00000342927.3	+	1	970	c.948G>T	c.(946-948)agG>agT	p.R316S		NM_001004136.1	NP_001004136.1	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T, member 2	316					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(21)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	37	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGAGCATCAGGGTGGCGACTG	0.562000													5	109					0.0293803	0.030416	1	1	0
EPHB3	2049	broad.mit.edu	37	3	184294823	184294823	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:184294823G>C	ENST00000330394.2	+	5	1658	c.1206G>C	c.(1204-1206)caG>caC	p.Q402H	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	402	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			TGCCTCGGCAGCTGGGCCTGA	0.622000													39	76					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132474620	132474620	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:132474620A>G	ENST00000333577.4	+	9	2738	c.2629A>G	c.(2629-2631)Ata>Gta	p.I877V	EP400_ENST00000330386.6_Missense_Mutation_p.I841V|EP400_ENST00000389561.2_Missense_Mutation_p.I841V|EP400_ENST00000389562.2_Missense_Mutation_p.I840V|EP400_ENST00000332482.4_Missense_Mutation_p.I804V			Q96L91	EP400_HUMAN	E1A binding protein p400	877					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GGCCCGGGAGATAGAGTGCTT	0.582000													60	124					0	0	1	0	0
C10orf54	64115	broad.mit.edu	37	10	73521421	73521421	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:73521421C>A	ENST00000394957.3	-	2	503	c.445G>T	c.(445-447)Gtg>Ttg	p.V149L	CDH23_ENST00000224721.6_Intron|C10orf54_ENST00000481568.1_5'UTR	NM_022153.1	NP_071436.1	Q9H7M9	GI24_HUMAN	chromosome 10 open reading frame 54	149	Ig-like.					integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	9						CTGATCTCCACCACCAGGCAG	0.642000													10	27					1.08611e-07	1.34977e-07	1	1	0
PAPPA2	60676	broad.mit.edu	37	1	176738909	176738909	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:176738909C>G	ENST00000367662.3	+	16	5654	c.4490C>G	c.(4489-4491)gCc>gGc	p.A1497G		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1497	Sushi 2.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GTCCCACCAGCCAAGCTGCAA	0.507000													26	131					0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26677675	26677675	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:26677675C>T	ENST00000256737.3	+	25	3432	c.2580C>T	c.(2578-2580)tgC>tgT	p.C860C	ANO3_ENST00000525139.1_Silent_p.C844C|ANO3_ENST00000531568.1_Silent_p.C714C|ANO3_ENST00000537978.1_Silent_p.C844C	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	860						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						CTCCCAGTTGCTTGAAGGGAT	0.333000													17	84					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155208579	155208579	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:155208579C>T	ENST00000460012.1	-	19	2653	c.2296G>A	c.(2296-2298)Gac>Aac	p.D766N	PLCH1_ENST00000447496.2_Missense_Mutation_p.D784N|PLCH1_ENST00000414191.1_Missense_Mutation_p.D766N|PLCH1_ENST00000340059.7_Missense_Mutation_p.D784N|PLCH1_ENST00000334686.6_Missense_Mutation_p.D766N|PLCH1_ENST00000494598.1_Missense_Mutation_p.D784N			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	784	C2.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			TTACCATTGTCATCTACCACA	0.323000													20	65					0	0	1	0	0
ABHD12B	145447	broad.mit.edu	37	14	51370853	51370853	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr14:51370853C>G	ENST00000337334.2	+	12	1019	c.1004C>G	c.(1003-1005)cCt>cGt	p.P335R	PYGL_ENST00000532462.1_Intron|ABHD12B_ENST00000395752.1_Missense_Mutation_p.P228R|ABHD12B_ENST00000353130.1_Missense_Mutation_p.P258R	NM_001206673.1	NP_001193602.1	Q7Z5M8	AB12B_HUMAN	abhydrolase domain containing 12B	335							hydrolase activity			breast(2)|endometrium(1)|large_intestine(2)|lung(5)	10	all_epithelial(31;0.00481)|Breast(41;0.148)					GTTATCTTTCCTCCTGGCTTC	0.443000													8	225					0	0	1	0	0
FAM90A1	55138	broad.mit.edu	37	12	8375101	8375101	+	Nonsense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:8375101G>A	ENST00000538603.1	-	7	1270	c.712C>T	c.(712-714)Cga>Tga	p.R238*	FAM90A1_ENST00000307435.6_Nonsense_Mutation_p.R238*	NM_018088.3	NP_060558.3	Q86YD7	F90A1_HUMAN	family with sequence similarity 90, member A1	238							nucleic acid binding|zinc ion binding			endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	25				Kidney(36;0.0866)		GGAACTTCTCGACAGCCACCC	0.677000													15	106					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46254604	46254604	+	Silent	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:46254604A>T	ENST00000334344.6	+	16	4966	c.4794A>T	c.(4792-4794)tcA>tcT	p.S1598S	ARID2_ENST00000457135.1_Silent_p.S206S|ARID2_ENST00000444670.1_Silent_p.S1208S|ARID2_ENST00000422737.1_Silent_p.S1449S|ARID2_ENST00000479608.1_3'UTR	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1598					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TGCCACCTTCACCAGCTGTAC	0.413000			"""N, S, F"""		hepatocellular carcinoma								8	68					0	0	1	0	0
NPHS2	7827	broad.mit.edu	37	1	179520478	179520478	+	Nonsense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:179520478G>A	ENST00000367615.4	-	8	1050	c.982C>T	c.(982-984)Cag>Tag	p.Q328*	AXDND1_ENST00000367618.3_Intron|NPHS2_ENST00000367616.4_Nonsense_Mutation_p.Q260*	NM_014625.2	NP_055440.1	Q9NP85	PODO_HUMAN	nephrosis 2, idiopathic, steroid-resistant (podocin)	328					excretion	integral to plasma membrane	protein binding			NS(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	20						GACAGAGACTGAAGGGTGTGG	0.532000													20	101					0	0	1	0	0
MCM6	4175	broad.mit.edu	37	2	136605726	136605726	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:136605726C>T	ENST00000264156.2	-	14	2010	c.1950G>A	c.(1948-1950)cgG>cgA	p.R650R	MCM6_ENST00000492091.1_5'UTR	NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	650					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	TATTCAGTAACCGGAAAGCTT	0.393000													8	58					0	0	1	0	0
MTR	4548	broad.mit.edu	37	1	236966853	236966853	+	Nonsense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:236966853C>T	ENST00000366577.5	+	2	554	c.160C>T	c.(160-162)Cag>Tag	p.Q54*	MTR_ENST00000535889.1_Nonsense_Mutation_p.Q54*|MTR_ENST00000418145.2_Intron	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	54	Hcy-binding.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	CTTCCGAGGTCAGGAATTTAA	0.443000													46	83					0	0	1	0	0
CTTNBP2NL	55917	broad.mit.edu	37	1	112999884	112999884	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:112999884C>A	ENST00000271277.6	+	6	1995	c.1770C>A	c.(1768-1770)acC>acA	p.T590T	CTTNBP2NL_ENST00000607039.1_3'UTR|RP4-671G15.3_ENST00000508462.1_RNA	NM_018704.2	NP_061174.1	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	590						actin cytoskeleton	protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	29		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGGCCTCACCCCTTCTCCAT	0.567000													3	102					0.150653	0.153123	1	1	0
OR5L1	219437	broad.mit.edu	37	11	55579114	55579114	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:55579114C>A	ENST00000333973.2	+	1	261	c.172C>A	c.(172-174)Ccc>Acc	p.P58T		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				GCTCCACACCCCCATGTACTT	0.463000													79	228					3.61922e-38	6.39091e-38	1	1	0
CACNA1I	8911	broad.mit.edu	37	22	39996625	39996625	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr22:39996625G>T	ENST00000336649.4	+	5	449	c.449G>T	c.(448-450)tGg>tTg	p.W150L	CACNA1I_ENST00000400164.3_Missense_Mutation_p.W150L|CACNA1I_ENST00000401624.1_Missense_Mutation_p.W150L|CACNA1I_ENST00000407673.1_Missense_Mutation_p.W150L|CACNA1I_ENST00000404898.1_Missense_Mutation_p.W150L|CACNA1I_ENST00000402142.3_Missense_Mutation_p.W150L			Q9P0X4	CAC1I_HUMAN	calcium channel, voltage-dependent, T type, alpha 1I subunit	150					axon guidance|signal transduction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity|protein binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|liver(2)|lung(27)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Melanoma(58;0.0749)				Flunarizine(DB04841)|Paramethadione(DB00617)|Verapamil(DB00661)	GGGGACACATGGAACCGCCTG	0.532000													5	29					1.06961e-07	1.34122e-07	1	1	0
PDGFRB	5159	broad.mit.edu	37	5	149497284	149497284	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:149497284C>A	ENST00000261799.4	-	22	3503	c.3034G>T	c.(3034-3036)Gtg>Ttg	p.V1012L		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	1012					aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TTGGGCTGCACGGCAGTATAG	0.637000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								19	81					1.10923e-09	1.45294e-09	1	1	0
WRN	7486	broad.mit.edu	37	8	30977802	30977802	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:30977802C>T	ENST00000298139.5	+	21	2741	c.2492C>T	c.(2491-2493)gCt>gTt	p.A831V		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	831	Helicase C-terminal.				base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		ATTAATAAAGCTGACATTCGC	0.393000			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				63	143					0	0	1	0	0
ZSCAN25	221785	broad.mit.edu	37	7	99227455	99227455	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:99227455G>T	ENST00000394152.2	+	8	1774	c.1447G>T	c.(1447-1449)Gag>Tag	p.E483*	ZSCAN25_ENST00000466948.1_Intron|ZSCAN25_ENST00000334715.3_Nonsense_Mutation_p.E483*|ZSCAN25_ENST00000262941.6_Nonsense_Mutation_p.E411*	NM_145115.2	NP_660090.2			zinc finger and SCAN domain containing 25																		CCACACTGGCGAGAAGCCATA	0.632000													8	79					9.70103e-10	1.28274e-09	1	1	0
SVEP1	79987	broad.mit.edu	37	9	113166770	113166770	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:113166770C>A	ENST00000401783.2	-	39	9839	c.9503G>T	c.(9502-9504)cGc>cTc	p.R3168L	SVEP1_ENST00000297826.5_Missense_Mutation_p.R1094L|SVEP1_ENST00000374469.1_Missense_Mutation_p.R3145L	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	3168	Sushi 29.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						AGGGAACCAGCGACCATCTTT	0.418000													78	286					2.78983e-34	4.84961e-34	1	1	0
MIS18A	54069	broad.mit.edu	37	21	33651113	33651113	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr21:33651113C>A	ENST00000290130.3	-	1	267	c.213G>T	c.(211-213)gaG>gaT	p.E71D	MIS18A-AS1_ENST00000453549.1_RNA	NM_018944.2	NP_061817.1	Q9NYP9	MS18A_HUMAN	MIS18 kinetochore protein A	71					cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(2)	7						CCGCCGCCTCCTCCTCCAGCT	0.701000													4	5					0.150653	0.153123	1	1	0
LAMA4	3910	broad.mit.edu	37	6	112496675	112496675	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:112496675G>T	ENST00000230538.7	-	11	1594	c.1197C>A	c.(1195-1197)aaC>aaA	p.N399K	LAMA4_ENST00000389463.4_Missense_Mutation_p.N392K|LAMA4_ENST00000424408.2_Missense_Mutation_p.N392K|LAMA4_ENST00000522006.1_Missense_Mutation_p.N392K	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	399	Domain II and I.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		GCATCTTGTTGTTGATCTCTG	0.498000													22	101					2.89027e-11	3.97234e-11	1	1	0
PREX1	57580	broad.mit.edu	37	20	47324938	47324938	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:47324938C>T	ENST00000396220.1	-	6	665	c.643G>A	c.(643-645)Ggc>Agc	p.G215S	PREX1_ENST00000371941.3_Missense_Mutation_p.G215S			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	215	DH.				actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity	p.G215S(2)		breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GGGTGCTTGCCGGGAGTCCTC	0.577000													58	199					0	0	1	0	0
SYCE1	93426	broad.mit.edu	37	10	135371400	135371400	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:135371400C>T	ENST00000368517.3	-	6	372	c.234G>A	c.(232-234)ctG>ctA	p.L78L	SPRN_ENST00000541506.1_Intron|SYCE1_ENST00000343131.5_Silent_p.L114L|SYCE1_ENST00000432597.2_Silent_p.L78L	NM_130784.2	NP_570140.1	Q8N0S2	SYCE1_HUMAN	synaptonemal complex central element protein 1	114					cell division	central element				breast(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(2)|stomach(3)|urinary_tract(1)	19		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;1.12e-06)|all cancers(32;1.43e-06)|Epithelial(32;1.71e-06)		CCTGGCAATGCAGCCGGAGGA	0.527000													17	57					0	0	1	0	0
LRRFIP1	9208	broad.mit.edu	37	2	238657878	238657878	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:238657878C>A	ENST00000244815.5	+	6	562	c.322C>A	c.(322-324)Ctg>Atg	p.L108M	LRRFIP1_ENST00000308482.9_Missense_Mutation_p.L236M|LRRFIP1_ENST00000392000.4_Missense_Mutation_p.L108M|LRRFIP1_ENST00000289175.6_Missense_Mutation_p.L76M	NM_004735.3	NP_004726.2	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting protein 1	108					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	29		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		TGCAGCCACGCTGGCCTCTCT	0.572000													13	46					1.02788e-11	1.4339e-11	1	1	0
SLC9B1	150159	broad.mit.edu	37	4	103822394	103822394	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:103822394G>T	ENST00000296422.7	-	12	1569	c.1428C>A	c.(1426-1428)gcC>gcA	p.A476A	SLC9B1_ENST00000394789.3_Intron|SLC9B1_ENST00000512651.2_5'UTR	NM_139173.3	NP_631912.2	Q4ZJI4	NHDC1_HUMAN	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	476						integral to membrane	solute:hydrogen antiporter activity										TGATCAAGATGGCTAAAAATG	0.463000													12	535					4.7546e-09	6.12718e-09	1	1	0
DCHS2	54798	broad.mit.edu	37	4	155241869	155241869	+	Missense_Mutation	SNP	A	A	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:155241869A>C	ENST00000357232.3	-	14	3316	c.3317T>G	c.(3316-3318)cTc>cGc	p.L1106R		NM_017639.3	NP_060109.2	Q6V1P9	PCD23_HUMAN	dachsous cadherin-related 2	1106	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(3)|endometrium(8)|kidney(5)|large_intestine(54)|lung(63)|ovary(4)|pancreas(1)|prostate(14)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	176	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GGGGTGGATGAGAAATGGATT	0.453000													7	389					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86964328	86964328	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:86964328C>T	ENST00000234701.3	+	14	2538	c.2187C>T	c.(2185-2187)agC>agT	p.S729S	CLCA1_ENST00000394711.1_Silent_p.S729S			A8K7I4	CLCA1_HUMAN	chloride channel accessory 1	729					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		TGTGTTTCAGCAGAACATCCT	0.428000													33	77					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127595198	127595198	+	Silent	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:127595198T>A	ENST00000508053.1	-	71	9662	c.8688A>T	c.(8686-8688)ctA>ctT	p.L2896L	FBN2_ENST00000262464.4_Silent_p.L2896L			P35556	FBN2_HUMAN	fibrillin 2	2896					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		CAAGCTCCCCTAGGAGGTAGT	0.512000													36	60					0	0	1	0	0
RHOT2	89941	broad.mit.edu	37	16	718356	718356	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:718356A>T	ENST00000315082.4	+	2	155	c.41A>T	c.(40-42)cAg>cTg	p.Q14L	RHOT2_ENST00000569943.2_3'UTR	NM_138769.2	NP_620124.1	Q8IXI1	MIRO2_HUMAN	ras homolog family member T2	14	Miro 1.				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|pancreas(2)|prostate(1)	13		Hepatocellular(780;0.0218)				CGCGCAGCCCAGGTGGGGAAG	0.771000													3	8					0	0	1	0	0
UBBP4	23666	broad.mit.edu	37	17	21731496	21731496	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:21731496G>T	ENST00000578713.1	+	2	575	c.571G>T	c.(571-573)Gat>Tat	p.D191Y	UBBP4_ENST00000584755.1_3'UTR|UBBP4_ENST00000583708.1_3'UTR																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						CATCCCCCCCGATCAGCAGAG	0.547000													11	35					7.03913e-09	9.00879e-09	1	1	0
ZNF768	79724	broad.mit.edu	37	16	30536853	30536853	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:30536853C>G	ENST00000380412.5	-	2	783	c.608G>C	c.(607-609)gGg>gCg	p.G203A	ZNF768_ENST00000562803.1_Missense_Mutation_p.G172A	NM_024671.3	NP_078947.3	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	203					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						GGGCTGCTCCCCAAACCCCTG	0.572000													15	131					0	0	1	0	0
SLC6A5	9152	broad.mit.edu	37	11	20629027	20629027	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:20629027T>C	ENST00000525748.1	+	5	1087	c.814T>C	c.(814-816)Tgt>Cgt	p.C272R		NM_004211.3	NP_004202.2	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 5	272					synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(34)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	63					Glycine(DB00145)	TTCTGCAGGCTGTGGCATCGC	0.438000													11	324					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61511551	61511551	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:61511551G>T	ENST00000266070.4	-	16	6082	c.5757C>A	c.(5755-5757)ccC>ccA	p.P1919P	DIDO1_ENST00000395343.1_Silent_p.P1919P	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1919	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					AATGACCAGGGGGTGGTCCTC	0.627000													14	36					1.49906e-05	1.73543e-05	1	1	0
COL22A1	169044	broad.mit.edu	37	8	139763750	139763750	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:139763750G>T	ENST00000303045.6	-	22	2482	c.2036C>A	c.(2035-2037)cCa>cAa	p.P679Q	COL22A1_ENST00000435777.1_Missense_Mutation_p.P679Q	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	679	Collagen-like 4.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TGGGCCTATTGGACCCTTTAG	0.468000										HNSCC(7;0.00092)			10	56					9.31168e-06	1.08023e-05	1	1	0
SCN5A	6331	broad.mit.edu	37	3	38616931	38616931	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:38616931G>A	ENST00000413689.1	-	20	3716	c.3523C>T	c.(3523-3525)Cgc>Tgc	p.R1175C	SCN5A_ENST00000455624.2_Missense_Mutation_p.R1174C|SCN5A_ENST00000450102.2_Missense_Mutation_p.R1121C|SCN5A_ENST00000451551.2_Missense_Mutation_p.R1121C|SCN5A_ENST00000449557.2_Missense_Mutation_p.R1121C|SCN5A_ENST00000423572.2_Missense_Mutation_p.R1174C|SCN5A_ENST00000443581.1_Missense_Mutation_p.R1174C|SCN5A_ENST00000425664.1_Missense_Mutation_p.R1175C|SCN5A_ENST00000333535.4_Missense_Mutation_p.R1175C|SCN5A_ENST00000414099.2_Missense_Mutation_p.R1175C	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1175					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	CAGGGACAGCGCCGGACACAG	0.602000													6	15					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000330386.6_Silent_p.Q2644Q|EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000332482.4_Silent_p.Q2688Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													6	44					0	0	1	0	0
ATP1B2	482	broad.mit.edu	37	17	7557992	7557992	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:7557992G>A	ENST00000250111.4	+	5	1006	c.599G>A	c.(598-600)tGt>tAt	p.C200Y		NM_001678.3	NP_001669.3	P14415	AT1B2_HUMAN	ATPase, Na+/K+ transporting, beta 2 polypeptide	200					ATP biosynthetic process|blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|sodium:potassium-exchanging ATPase activity	p.0?(2)|p.?(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|pancreas(1)	10		all_cancers(10;0.000178)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;2.55e-06)|READ - Rectum adenocarcinoma(115;0.168)		AATGTTACCTGTGCTGGGAAG	0.512000													37	144					0	0	1	0	0
PLS3	5358	broad.mit.edu	37	X	114882230	114882230	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:114882230C>T	ENST00000420625.2	+	15	1787	c.1653C>T	c.(1651-1653)tcC>tcT	p.S551S	PLS3_ENST00000539310.1_Silent_p.S506S|PLS3_ENST00000537301.1_Silent_p.S538S|PLS3_ENST00000543070.1_Silent_p.S145S|PLS3_ENST00000355899.3_Silent_p.S551S|PLS3_ENST00000289290.3_Silent_p.S515S	NM_001136025.3|NM_001172335.1	NP_001129497.1|NP_001165806.1	P13797	PLST_HUMAN	plastin 3	551	Actin-binding 2.|CH 4.					cytoplasm	actin binding|calcium ion binding			NS(2)|breast(4)|endometrium(2)|kidney(4)|large_intestine(3)|lung(11)	26						CGATCAGCTCCAGTTTGGCAG	0.378000													57	55					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25332861	25332861	+	RNA	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr15:25332861G>T	ENST00000546682.1	+	0	586				SNORD116-21_ENST00000384529.1_lincRNA|SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA	NR_003361.1																						AACAAAATGAGTGAAAACTCT	0.453000													25	269					1.61788e-16	2.48699e-16	1	1	0
WFIKKN1	117166	broad.mit.edu	37	16	683127	683127	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:683127C>G	ENST00000319070.2	+	2	1039	c.717C>G	c.(715-717)aaC>aaG	p.N239K		NM_053284.2	NP_444514.1	Q96NZ8	WFKN1_HUMAN	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1	239	Ig-like C2-type.					extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|prostate(1)|upper_aerodigestive_tract(1)	4		Hepatocellular(780;0.00335)				TGTATGGCAACGTGGTGGTCA	0.662000													3	31					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49670364	49670364	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:49670364A>T	ENST00000561648.1	-	4	2752	c.2699T>A	c.(2698-2700)cTg>cAg	p.L900Q	ZNF423_ENST00000567169.1_Missense_Mutation_p.L783Q|ZNF423_ENST00000563137.2_Missense_Mutation_p.L840Q|ZNF423_ENST00000562871.1_Missense_Mutation_p.L840Q|ZNF423_ENST00000262383.2_Missense_Mutation_p.L900Q|ZNF423_ENST00000562520.1_Missense_Mutation_p.L840Q|ZNF423_ENST00000535559.1_Missense_Mutation_p.L783Q	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	900					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				ATTCTGCAGCAGCACCTCCAT	0.607000													31	98					0	0	1	0	0
RTP2	344892	broad.mit.edu	37	3	187416465	187416465	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:187416465G>T	ENST00000358241.1	-	2	927	c.499C>A	c.(499-501)Ccc>Acc	p.P167T		NM_001004312.2	NP_001004312.2	Q5QGT7	RTP2_HUMAN	receptor (chemosensory) transporter protein 2	167					protein insertion into membrane	cell surface|integral to membrane|plasma membrane	olfactory receptor binding			large_intestine(3)|lung(14)|skin(1)	18	all_cancers(143;4.06e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0515)		TTCTCGCTGGGCTTCCAGTGA	0.647000													11	25					4.68919e-08	5.94674e-08	1	1	0
CSMD1	64478	broad.mit.edu	37	8	3611481	3611481	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:3611481C>A	ENST00000520002.1	-	6	1457	c.902G>T	c.(901-903)cGa>cTa	p.R301L	CSMD1_ENST00000602723.1_Missense_Mutation_p.R301L|CSMD1_ENST00000400186.3_Missense_Mutation_p.R301L|CSMD1_ENST00000602557.1_Missense_Mutation_p.R301L|CSMD1_ENST00000542608.1_Missense_Mutation_p.R301L|CSMD1_ENST00000539096.1_Missense_Mutation_p.R301L|CSMD1_ENST00000537824.1_Missense_Mutation_p.R301L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	301	CUB 2.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCCTTTGCGTCGGTGGTTGCT	0.423000													7	27					0.000274275	0.000301271	1	1	0
RCN1	5954	broad.mit.edu	37	11	32124968	32124968	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:32124968A>T	ENST00000054950.3	+	5	1123	c.830A>T	c.(829-831)gAt>gTt	p.D277V	RP1-65P5.3_ENST00000533009.1_RNA|RCN1_ENST00000532942.1_Missense_Mutation_p.D226V	NM_002901.2	NP_002892.1	Q15293	RCN1_HUMAN	reticulocalbin 1, EF-hand calcium binding domain	277	EF-hand 5.					endoplasmic reticulum lumen	calcium ion binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(6)	17	Lung SC(675;0.225)					CTCCCTCAAGATTATGATCAT	0.453000													3	109					0	0	1	0	0
CDS1	1040	broad.mit.edu	37	4	85566403	85566403	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:85566403G>T	ENST00000295887.5	+	12	1604	c.1181G>T	c.(1180-1182)gGt>gTt	p.G394V		NM_001263.3	NP_001254.2	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	394					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|ovary(1)	20		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		CCTGGACATGGTGGGATAATG	0.313000													13	65					2.39187e-15	3.56862e-15	1	1	0
TTN	7273	broad.mit.edu	37	2	179581883	179581883	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:179581883G>T	ENST00000589042.1	-	88	25802	c.25578C>A	c.(25576-25578)taC>taA	p.Y8526*	TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Nonsense_Mutation_p.Y7282*|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Nonsense_Mutation_p.Y8209*|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8209	Ig-like 68.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATAGCAGGTGTACTGCCCGG	0.473000													5	43					0.0293803	0.030416	1	1	0
C7orf62	219557	broad.mit.edu	37	7	88424178	88424178	+	Missense_Mutation	SNP	G	G	A	rs138556749		TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:88424178G>A	ENST00000297203.2	-	2	264	c.79C>T	c.(79-81)Cgt>Tgt	p.R27C	ZNF804B_ENST00000333190.4_Intron	NM_152706.3	NP_689919.1	Q8TBZ9	CG062_HUMAN	chromosome 7 open reading frame 62	27										NS(1)|breast(1)|endometrium(3)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	30						TAATTGCTACGTGGGACTTGG	0.418000													18	61					0	0	1	0	0
SNAP47	116841	broad.mit.edu	37	1	227935689	227935689	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:227935689G>A	ENST00000366759.4	+	2	801	c.387G>A	c.(385-387)cgG>cgA	p.R129R	SNAP47_ENST00000366760.1_Intron|SNAP47_ENST00000315781.5_Silent_p.R129R	NM_053052.3	NP_444280.2	Q5SQN1	SNP47_HUMAN	synaptosomal-associated protein, 47kDa	129						endomembrane system|membrane|perinuclear region of cytoplasm				endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17						GCTCCCTGCGGCCAAGTCGAA	0.552000													32	112					0	0	1	0	0
PCSK6	5046	broad.mit.edu	37	15	101924557	101924557	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr15:101924557C>A	ENST00000348070.1	-	11	1380	c.1381G>T	c.(1381-1383)Gac>Tac	p.D461Y	PCSK6_ENST00000561177.1_5'UTR|PCSK6_ENST00000344273.2_Missense_Mutation_p.D461Y|PCSK6_ENST00000398181.2_Missense_Mutation_p.D461Y|PCSK6_ENST00000331826.7_Missense_Mutation_p.D296Y|PCSK6_ENST00000358417.3_Missense_Mutation_p.D461Y	NM_002570.3|NM_138320.1	NP_002561.1|NP_612193.1	P29122	PCSK6_HUMAN	proprotein convertase subtilisin/kexin type 6	462					glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			ACTTTCCAGTCGCTCGCTTTC	0.582000													7	26					0.000157383	0.000174246	1	1	0
ROBO4	54538	broad.mit.edu	37	11	124766982	124766982	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:124766982G>T	ENST00000306534.3	-	2	731	c.246C>A	c.(244-246)ctC>ctA	p.L82L	ROBO4_ENST00000533054.1_Intron|ROBO4_ENST00000526899.1_5'UTR	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	82	Ig-like C2-type 1.				angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CATCAGGCAGGAGGTGGTGTG	0.657000													10	46					3.86212e-05	4.40708e-05	1	1	0
OR5L1	219437	broad.mit.edu	37	11	55579559	55579559	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:55579559A>G	ENST00000333973.2	+	1	706	c.617A>G	c.(616-618)aAt>aGt	p.N206S		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				GCCACTTTGAATGAGAGTGTT	0.478000													64	159					0	0	1	0	0
RHCG	51458	broad.mit.edu	37	15	90039789	90039789	+	Translation_Start_Site	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr15:90039789C>A	ENST00000268122.4	-	0	55				RHCG_ENST00000544600.1_De_novo_Start_InFrame	NM_016321.1	NP_057405.1	Q9UBD6	RHCG_HUMAN	Rh family, C glycoprotein						amine transport|cellular ion homeostasis|epithelial cell differentiation|transepithelial ammonium transport	apical plasma membrane|basolateral plasma membrane|cytoplasmic vesicle|integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(9)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Lung NSC(78;0.0237)|all_lung(78;0.0478)					GCAGGGGTGCCTGGCCGGGCT	0.711000													21	26					2.32416e-17	3.62257e-17	1	1	0
BRMS1L	84312	broad.mit.edu	37	14	36339639	36339639	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr14:36339639A>G	ENST00000216807.7	+	10	1127	c.928A>G	c.(928-930)Att>Gtt	p.I310V	BRMS1L_ENST00000543183.1_Missense_Mutation_p.I262V	NM_032352.3	NP_115728.2	Q5PSV4	BRM1L_HUMAN	breast cancer metastasis-suppressor 1-like	310					regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9	Breast(36;0.137)|Hepatocellular(127;0.158)		Lung(8;1.7e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.00467)|all cancers(34;0.0157)|BRCA - Breast invasive adenocarcinoma(188;0.158)	GBM - Glioblastoma multiforme(112;0.0333)		TAAGCTTTACATTTCACAGCT	0.289000													7	275					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62302673	62302673	+	Nonsense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr15:62302673G>A	ENST00000261517.5	-	13	1082	c.1009C>T	c.(1009-1011)Cag>Tag	p.Q337*	VPS13C_ENST00000249837.3_Nonsense_Mutation_p.Q294*|VPS13C_ENST00000395898.3_Nonsense_Mutation_p.Q294*|VPS13C_ENST00000395896.4_Nonsense_Mutation_p.Q337*	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	337					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						AATCATACCTGAGGTTTGGTC	0.368000													52	90					0	0	1	0	0
IGHV3-48	28424	broad.mit.edu	37	14	106993813	106993813	+	RNA	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr14:106993813C>A	ENST00000390624.2	-	0	430																											CTCACTGTGTCTCTCGCACAG	0.577000													10	419					0.000151284	0.000168161	1	1	0
SYT10	341359	broad.mit.edu	37	12	33538176	33538176	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:33538176C>A	ENST00000228567.3	-	4	1424	c.1128G>T	c.(1126-1128)acG>acT	p.T376T	SYT10_ENST00000535526.1_Silent_p.T195T	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	376	C2 2.					cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TACGCCCAGCCGTCGGTAGGT	0.443000													16	65					3.52763e-06	4.13533e-06	1	1	0
DMKN	93099	broad.mit.edu	37	19	35996649	35996649	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:35996649C>A	ENST00000339686.3	-	9	1281	c.1105G>T	c.(1105-1107)Ggt>Tgt	p.G369C	DMKN_ENST00000440396.1_Missense_Mutation_p.G399C|DMKN_ENST00000424570.2_Missense_Mutation_p.G381C|DMKN_ENST00000602781.1_Missense_Mutation_p.G82C|DMKN_ENST00000462126.1_5'UTR|DMKN_ENST00000451297.2_Missense_Mutation_p.G352C|DMKN_ENST00000419602.1_Missense_Mutation_p.G358C|DMKN_ENST00000429837.1_Missense_Mutation_p.G328C|DMKN_ENST00000458071.1_Missense_Mutation_p.G114C|DMKN_ENST00000480502.1_Missense_Mutation_p.G82C|DMKN_ENST00000414866.2_Missense_Mutation_p.G82C|DMKN_ENST00000474928.1_Missense_Mutation_p.G16C|DMKN_ENST00000467637.1_Missense_Mutation_p.G94C|DMKN_ENST00000436012.1_Missense_Mutation_p.G65C|DMKN_ENST00000402589.2_Missense_Mutation_p.G82C|DMKN_ENST00000443640.1_Missense_Mutation_p.G132C|DMKN_ENST00000492341.2_Missense_Mutation_p.G16C|DMKN_ENST00000488892.1_Missense_Mutation_p.G65C|DMKN_ENST00000392206.2_Missense_Mutation_p.G82C|DMKN_ENST00000472252.2_Missense_Mutation_p.G16C|DMKN_ENST00000447113.2_Missense_Mutation_p.G419C|DMKN_ENST00000461300.1_Missense_Mutation_p.G16C|DMKN_ENST00000418261.1_Missense_Mutation_p.G369C	NM_033317.4	NP_201574.3	Q6E0U4	DMKN_HUMAN	dermokine	369						extracellular region				NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|ovary(1)|prostate(1)|skin(2)	27	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			TTGATGAAACCCAGCTTGGAT	0.478000													9	75					6.40141e-05	7.24541e-05	1	1	0
STOX1	219736	broad.mit.edu	37	10	70645798	70645798	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:70645798G>T	ENST00000298596.6	+	3	2329	c.2246G>T	c.(2245-2247)cGt>cTt	p.R749L	STOX1_ENST00000421961.2_Missense_Mutation_p.R639L|STOX1_ENST00000399162.2_Intron|STOX1_ENST00000399165.4_Intron|STOX1_ENST00000399169.4_Missense_Mutation_p.R749L	NM_152709.4	NP_689922.3	Q6ZVD7	STOX1_HUMAN	storkhead box 1	749						cytoplasm|nucleolus	DNA binding			breast(5)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|prostate(1)|skin(3)	28						GACGACTTACGTCAAATGCTG	0.438000													30	47					8.16721e-17	1.25892e-16	1	1	0
OR51E2	81285	broad.mit.edu	37	11	4703622	4703622	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:4703622G>T	ENST00000396950.3	-	2	559	c.320C>A	c.(319-321)tCa>tAa	p.S107*		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	107					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		TTCAATGGCTGAGAGGGCATG	0.502000													25	34					3.73148e-12	5.28468e-12	1	1	0
ALKBH5	54890	broad.mit.edu	37	17	18111594	18111594	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:18111594C>T	ENST00000399138.4	+	4	1074	c.1069C>T	c.(1069-1071)Cgg>Tgg	p.R357W	ALKBH5_ENST00000541285.1_Missense_Mutation_p.R16W	NM_017758.3	NP_060228.3	Q6P6C2	ALKB5_HUMAN	alkB, alkylation repair homolog 5 (E. coli)	357						integral to membrane	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(2)|ovary(1)|skin(1)	10	all_neural(463;0.228)					GCCCACACACCGGCGGAGGGG	0.602000													32	78					0	0	1	0	0
DUS2	54920	broad.mit.edu	37	16	68107935	68107935	+	Splice_Site	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:68107935A>T	ENST00000565263.1	+	13	1304		c.e13-1		DUS2L_ENST00000432752.1_Splice_Site|DUS2L_ENST00000358896.6_Splice_Site	NM_017803.3	NP_060273.1	Q9NX74	DUS2L_HUMAN							tRNA processing	endoplasmic reticulum	double-stranded RNA binding|flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(12)|ovary(1)|skin(1)|stomach(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0131)|Epithelial(162;0.0564)		TTCTTTTCTCAGGCGGTGCAG	0.542000													8	49					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19473656	19473656	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:19473656C>A	ENST00000507958.1	-	15	3042	c.2052G>T	c.(2050-2052)gaG>gaT	p.E684D	CDH18_ENST00000274170.4_Missense_Mutation_p.E684D|CDH18_ENST00000382275.1_Missense_Mutation_p.E684D|CDH18_ENST00000510297.1_5'UTR			Q13634	CAD18_HUMAN	cadherin 18, type 2	684					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GGTACTTGAGCTCCTCAGCAG	0.502000													15	73					1.15088e-07	1.42077e-07	1	1	0
LDHA	3939	broad.mit.edu	37	11	18422549	18422549	+	Nonsense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:18422549C>G	ENST00000422447.3	+	4	683	c.410C>G	c.(409-411)tCa>tGa	p.S137*	LDHA_ENST00000540430.1_Nonsense_Mutation_p.S166*|LDHA_ENST00000396222.2_Nonsense_Mutation_p.S137*|LDHA_ENST00000379412.5_Nonsense_Mutation_p.S137*|LDHA_ENST00000227157.4_Nonsense_Mutation_p.S137*|LDHA_ENST00000430553.2_Intron|LDHA_ENST00000542179.1_Nonsense_Mutation_p.S137*	NM_001135239.1|NM_005566.3	NP_001128711.1|NP_005557.1	P00338	LDHA_HUMAN	lactate dehydrogenase A	137					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)|endometrium(1)|large_intestine(4)|lung(4)	12					NADH(DB00157)	CTTATTGTTTCAAATCCAGGT	0.299000													6	68					0	0	1	0	0
NDUFB8	4714	broad.mit.edu	37	10	102286804	102286804	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:102286804G>A	ENST00000557395.1	-	3	269	c.240C>T	c.(238-240)gaC>gaT	p.D80D	NDUFB8_ENST00000299166.4_Silent_p.D80D|NDUFB8_ENST00000370322.1_Silent_p.D49D|SEC31B_ENST00000535773.1_5'UTR|NDUFB8_ENST00000370320.4_Silent_p.D80D|NDUFB8_ENST00000531258.1_Silent_p.D80D			O95169	NDUB8_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	80					mitochondrial electron transport, NADH to ubiquinone|transport	endoplasmic reticulum|integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			endometrium(2)|lung(2)	4		Colorectal(252;0.234)		Epithelial(162;5.68e-10)|all cancers(201;4.05e-08)	NADH(DB00157)	GCTGTGAGCGGTCAGGGAGCT	0.517000													10	54					0	0	1	0	0
GANC	2595	broad.mit.edu	37	15	42631929	42631929	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr15:42631929G>A	ENST00000318010.8	+	17	2146	c.1906G>A	c.(1906-1908)Gga>Aga	p.G636R		NM_198141.2	NP_937784.2	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	636					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		GTACCAGGCTGGAGCCTACCA	0.572000													3	77					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767825	77767825	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:77767825G>T	ENST00000521891.2	+	10	9116	c.8668G>T	c.(8668-8670)Gat>Tat	p.D2890Y	ZFHX4_ENST00000518282.1_Missense_Mutation_p.D2864Y|ZFHX4_ENST00000050961.6_Missense_Mutation_p.D2845Y|ZFHX4_ENST00000455469.2_Missense_Mutation_p.D2845Y	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2845						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TTACATCACAGATGACCCGGA	0.502000										HNSCC(33;0.089)			8	44					3.09899e-07	3.74293e-07	1	1	0
POC5	134359	broad.mit.edu	37	5	74981259	74981259	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:74981259C>A	ENST00000428202.2	-	10	1369	c.1180G>T	c.(1180-1182)Gga>Tga	p.G394*	POC5_ENST00000514838.2_Nonsense_Mutation_p.G366*|POC5_ENST00000446329.2_Nonsense_Mutation_p.G369*|POC5_ENST00000510798.1_Nonsense_Mutation_p.G277*|POC5_ENST00000380475.2_Nonsense_Mutation_p.G277*	NM_001099271.1	NP_001092741.1	Q8NA72	POC5_HUMAN	POC5 centriolar protein	394					cell cycle	centriole		p.G368fs*102(1)		breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						TGTTCTTTTCCTTGAACACCA	0.453000													34	100					5.59293e-11	7.61184e-11	1	1	0
CELSR3	1951	broad.mit.edu	37	3	48689382	48689382	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:48689382C>G	ENST00000544264.1	-	12	6131	c.5851G>C	c.(5851-5853)Gcc>Ccc	p.A1951P	CELSR3_ENST00000164024.4_Missense_Mutation_p.A1951P			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	1951	EGF-like 5; calcium-binding.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GGCCCAGAGGCACAGGCGTTG	0.677000													29	42					0	0	1	0	0
MMP16	4325	broad.mit.edu	37	8	89086932	89086932	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:89086932C>A	ENST00000286614.6	-	7	1404	c.1123G>T	c.(1123-1125)Gat>Tat	p.D375Y	MMP16_ENST00000544227.1_5'UTR	NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	375	Hemopexin-like 1.				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						GGGTATCCATCCATCACCCTG	0.478000													21	188					9.57634e-11	1.30015e-10	1	1	0
GABRA5	2558	broad.mit.edu	37	15	27128648	27128648	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr15:27128648C>A	ENST00000335625.5	+	6	1329	c.441C>A	c.(439-441)acC>acA	p.T147T	GABRA5_ENST00000355395.5_Silent_p.T147T|GABRB3_ENST00000541819.2_Intron|GABRA5_ENST00000557449.1_Intron|GABRA5_ENST00000400081.3_Silent_p.T147T	NM_000810.3	NP_000801.1	P31644	GBRA5_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 5	147					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(26)|ovary(1)|upper_aerodigestive_tract(1)	49		all_lung(180;4.59e-13)|Breast(32;0.000563)|Colorectal(260;0.227)		all cancers(64;1.45e-08)|Epithelial(43;4.96e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0232)|Lung(196;0.182)	Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ACAACATGACCACGCCCAACA	0.667000													5	30					0.000602214	0.00065504	1	1	0
MYH7	4625	broad.mit.edu	37	14	23894195	23894195	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr14:23894195A>G	ENST00000355349.3	-	22	2624	c.2462T>C	c.(2461-2463)tTc>tCc	p.F821S		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	821					adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GACCCCCATGAAGGCCCGAAT	0.547000													22	65					0	0	1	0	0
MMP14	4323	broad.mit.edu	37	14	23315028	23315028	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr14:23315028C>T	ENST00000311852.6	+	10	1790	c.1529C>T	c.(1528-1530)tCg>tTg	p.S510L	MMP14_ENST00000548162.1_Intron	NM_004995.2	NP_004986.1	P50281	MMP14_HUMAN	matrix metallopeptidase 14 (membrane-inserted)	510						extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	20	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		GGCTGCCCATCGGGAGGCCGG	0.617000													3	78					0	0	1	0	0
UNC5A	90249	broad.mit.edu	37	5	176289624	176289624	+	Splice_Site	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:176289624G>C	ENST00000329542.4	+	2	344		c.e2-1			NM_133369.2	NP_588610.2	Q6ZN44	UNC5A_HUMAN	unc-5 homolog A (C. elegans)						apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				endometrium(4)|kidney(3)|large_intestine(2)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	34	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCTGCCGCAGGTGCCCAGCA	0.657000													8	23					0	0	1	0	0
TTC26	79989	broad.mit.edu	37	7	138831962	138831962	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:138831962G>T	ENST00000464848.1	+	6	551	c.471G>T	c.(469-471)ttG>ttT	p.L157F	TTC26_ENST00000343187.4_Missense_Mutation_p.L126F|TTC26_ENST00000481482.1_3'UTR|TTC26_ENST00000474035.2_Missense_Mutation_p.L157F|TTC26_ENST00000495038.1_Intron|TTC26_ENST00000478836.2_Intron|TTC26_ENST00000430935.1_Missense_Mutation_p.L157F			A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26	157							binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	24						AACTCAGTTTGGCCTCAATCC	0.368000													17	69					1.99824e-07	2.43986e-07	1	1	0
STX3	6809	broad.mit.edu	37	11	59556354	59556354	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:59556354G>C	ENST00000535361.1	+	4	770	c.223G>C	c.(223-225)Gat>Cat	p.D75H	STX3_ENST00000529177.1_Missense_Mutation_p.D75H|STX3_ENST00000437946.2_5'UTR|STX3_ENST00000300150.7_Missense_Mutation_p.D44H|STX3_ENST00000337979.4_Missense_Mutation_p.D75H			Q13277	STX3_HUMAN	syntaxin 3	75					cellular response to oxidative stress|intracellular protein transport|neuron projection development|neurotransmitter transport	apical plasma membrane|azurophil granule|cell-cell junction|growth cone|integral to membrane|plasma membrane enriched fraction|SNARE complex|specific granule	arachidonic acid binding|SNAP receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|skin(1)	13						AGAAACCAAGGATGACCTAGA	0.468000													8	26					0	0	1	0	0
ZBTB41	360023	broad.mit.edu	37	1	197168592	197168592	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:197168592C>A	ENST00000367405.4	-	1	1080	c.1012G>T	c.(1012-1014)Ggt>Tgt	p.G338C	ZBTB41_ENST00000467322.1_5'UTR	NM_194314.2	NP_919290.2	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	338					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(11)|lung(11)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)	40						ACAGAATCACCAGCCTCAGGT	0.388000													12	125					0.00136819	0.00147385	1	1	0
ADRB3	155	broad.mit.edu	37	8	37822813	37822813	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:37822813G>A	ENST00000345060.3	-	1	1670	c.1175C>T	c.(1174-1176)gCg>gTg	p.A392V	ADRB3_ENST00000520341.1_5'UTR	NM_000025.2	NP_000016.1	P13945	ADRB3_HUMAN	adrenoceptor beta 3	392					carbohydrate metabolic process|energy reserve metabolic process|positive regulation of MAPKKK cascade	integral to plasma membrane|receptor complex	beta3-adrenergic receptor activity|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)	9	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)		Norepinephrine(DB00368)|Pindolol(DB00960)|Propranolol(DB00571)	CCTGGGCTGCGCTGGGCTGCT	0.731000													3	8					0	0	1	0	0
HELB	92797	broad.mit.edu	37	12	66704010	66704010	+	Silent	SNP	T	T	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:66704010T>C	ENST00000247815.4	+	4	1361	c.1302T>C	c.(1300-1302)aaT>aaC	p.N434N		NM_033647.3	NP_387467.2	Q8NG08	HELB_HUMAN	helicase (DNA) B	434					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	40			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		ATGGTGAAAATGAAATTAATG	0.413000													3	157					0	0	1	0	0
LCP2	3937	broad.mit.edu	37	5	169685157	169685157	+	Silent	SNP	A	A	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:169685157A>C	ENST00000046794.5	-	16	1599	c.984T>G	c.(982-984)ccT>ccG	p.P328P	LCP2_ENST00000521416.1_Silent_p.P123P	NM_005565.3	NP_005556.1	Q13094	LCP2_HUMAN	lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)	328					immune response|platelet activation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	cytosol	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	23	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	OV - Ovarian serous cystadenocarcinoma(192;0.247)		GCTGGGGCAAAGGTCTCTGAT	0.498000													10	117					0	0	1	0	0
STK11	6794	broad.mit.edu	37	19	1219356	1219356	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:1219356G>T	ENST00000326873.7	+	3	1581	c.408G>T	c.(406-408)atG>atT	p.M136I	STK11_ENST00000585748.1_3'UTR	NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	136	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(2)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGTGGCATGCAGGAAATGC	0.701000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			5	6					8.12818e-05	9.14421e-05	1	1	0
SNTG1	54212	broad.mit.edu	37	8	51705299	51705299	+	Silent	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:51705299T>A	ENST00000522124.1	+	19	2125	c.1464T>A	c.(1462-1464)gcT>gcA	p.A488A	SNTG1_ENST00000518864.1_Silent_p.A488A|SNTG1_ENST00000276467.5_Silent_p.A451A|SNTG1_ENST00000517473.1_Silent_p.A451A	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	488					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				CCAAGGTAGCTTGTTTGGACC	0.413000													95	125					0	0	1	0	0
DFNB31	25861	broad.mit.edu	37	9	117240845	117240845	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:117240845C>A	ENST00000362057.3	-	2	993	c.825G>T	c.(823-825)ggG>ggT	p.G275G	DFNB31_ENST00000374057.3_Silent_p.G275G|DFNB31_ENST00000265134.6_5'UTR	NM_001173425.1|NM_015404.3	NP_001166896.1|NP_056219.3	Q9P202	WHRN_HUMAN	deafness, autosomal recessive 31	275					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|ovary(5)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TTTTCTCATCCCCTCCTTGCA	0.652000													19	85					4.7796e-09	6.13108e-09	1	1	0
DNAH9	1770	broad.mit.edu	37	17	11757643	11757643	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:11757643G>C	ENST00000262442.3	+	50	9899	c.9831G>C	c.(9829-9831)gaG>gaC	p.E3277D	DNAH9_ENST00000454412.2_Missense_Mutation_p.E3277D	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	3277	Stalk (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GATTTTATGAGGTGTTCTGTG	0.542000													24	95					0	0	1	0	0
KCNU1	157855	broad.mit.edu	37	8	36793301	36793301	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:36793301A>G	ENST00000399881.3	+	27	3350	c.3313A>G	c.(3313-3315)Ata>Gta	p.I1105V		NM_001031836.2	NP_001027006.2	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	1105						voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(31)|ovary(1)|urinary_tract(1)	57				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		TCCTAAGCAAATAGCATGGAA	0.373000													19	141					0	0	1	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43847849	43847849	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:43847849G>A	ENST00000389420.3	-	12	1620	c.1621C>T	c.(1621-1623)Cgt>Tgt	p.R541C	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.R541C	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	541	Disintegrin.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		AGCCCATGACGGCAATGCTAT	0.368000													13	14					0	0	1	0	0
SGPP2	130367	broad.mit.edu	37	2	223339308	223339308	+	Missense_Mutation	SNP	G	G	A	rs138702204	by1000genomes	TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:223339308G>A	ENST00000321276.7	+	2	327	c.241G>A	c.(241-243)Gtg>Atg	p.V81M		NM_152386.2	NP_689599.2	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphatase 2	81					sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity	p.V81M(2)		central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	18		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		GAAGTACGTCGTGAAGAATTA	0.363000													20	105					0	0	1	0	0
HSPA12A	259217	broad.mit.edu	37	10	118434621	118434621	+	Missense_Mutation	SNP	C	C	T	rs146839286	by1000genomes	TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:118434621C>T	ENST00000369209.3	-	12	1803	c.1699G>A	c.(1699-1701)Gtc>Atc	p.V567I		NM_025015.2	NP_079291.2	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	567							ATP binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32				all cancers(201;0.0158)		TTGTCAAAGACGTCGGTGCAC	0.617000													13	62					0	0	1	0	0
UPB1	51733	broad.mit.edu	37	22	24919673	24919673	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr22:24919673G>T	ENST00000413389.2	+	9	2392	c.799G>T	c.(799-801)Gat>Tat	p.D267Y	UPB1_ENST00000498140.1_3'UTR|UPB1_ENST00000326010.5_Missense_Mutation_p.D335Y			Q9UBR1	BUP1_HUMAN	ureidopropionase, beta	335	CN hydrolase.				pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	cytosol	beta-ureidopropionase activity|metal ion binding			endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	22	Colorectal(2;0.0339)					CCGTAGCCGGGATGGACTGCT	0.552000													29	85					1.36615e-20	2.21602e-20	1	1	0
ZNF530	348327	broad.mit.edu	37	19	58115697	58115697	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:58115697G>T	ENST00000332854.6	+	2	303	c.83G>T	c.(82-84)tGg>tTg	p.W28L	ZNF530_ENST00000597864.1_5'UTR	NM_020880.3	NP_065931.3	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	28	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(6)|skin(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CAGGAGGAGTGGGAGCTCCTT	0.517000													35	105					7.04047e-22	1.15887e-21	1	1	0
PSD4	23550	broad.mit.edu	37	2	113942965	113942965	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:113942965G>T	ENST00000245796.6	+	4	1392	c.1197G>T	c.(1195-1197)tgG>tgT	p.W399C	PSD4_ENST00000441564.2_Missense_Mutation_p.W399C	NM_012455.2	NP_036587.2	Q8NDX1	PSD4_HUMAN	pleckstrin and Sec7 domain containing 4	399					regulation of ARF protein signal transduction	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(2)|large_intestine(4)|lung(13)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						CTGAGGGCTGGCAGAGAGGAG	0.582000													40	152					1.32667e-27	2.2501e-27	1	1	0
CABYR	26256	broad.mit.edu	37	18	21739529	21739529	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr18:21739529C>T	ENST00000399496.3	+	5	800	c.635C>T	c.(634-636)tCa>tTa	p.S212L	RP11-799B12.4_ENST00000583267.1_lincRNA|CABYR_ENST00000399481.2_3'UTR|CABYR_ENST00000415309.2_Intron|CABYR_ENST00000399499.1_Missense_Mutation_p.S212L|CABYR_ENST00000581397.1_Missense_Mutation_p.S212L|CABYR_ENST00000327201.6_Missense_Mutation_p.S114L	NM_012189.2|NM_153769.1	NP_036321.2|NP_722453.1	O75952	CABYR_HUMAN	calcium binding tyrosine-(Y)-phosphorylation regulated	397					ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)	11	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					GGTCACCCATCACCGCCACCT	0.458000													3	72					0	0	1	0	0
CACNG3	10368	broad.mit.edu	37	16	24372760	24372760	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:24372760A>G	ENST00000005284.3	+	4	1726	c.524A>G	c.(523-525)tAt>tGt	p.Y175C		NM_006539.3	NP_006530.1	O60359	CCG3_HUMAN	calcium channel, voltage-dependent, gamma subunit 3	175					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|endocytic vesicle membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|skin(2)	40				GBM - Glioblastoma multiforme(48;0.0809)		AGTTACTCCTATGGTTGGTCC	0.448000													27	127					0	0	1	0	0
ZBTB39	9880	broad.mit.edu	37	12	57398632	57398632	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:57398632G>A	ENST00000300101.2	-	2	155	c.70C>T	c.(70-72)Cgg>Tgg	p.R24W		NM_014830.2	NP_055645.1	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	24					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|liver(1)|lung(3)|prostate(1)	16						TCTGAGAGCCGGCACTTGTTG	0.552000													61	163					0	0	1	0	0
CHRM4	1132	broad.mit.edu	37	11	46407288	46407288	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:46407288C>A	ENST00000433765.2	-	1	819	c.820G>T	c.(820-822)Gag>Tag	p.E274*		NM_000741.2	NP_000732.2	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	274					cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	20				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	GGGGGGGCCTCCTCCAGCTTG	0.672000													6	9					0.217242	0.220002	1	1	0
MXRA5	25878	broad.mit.edu	37	X	3241975	3241975	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:3241975G>T	ENST00000217939.6	-	5	1905	c.1751C>A	c.(1750-1752)aCa>aAa	p.T584K		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	584	Ig-like C2-type 2.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AATTGTCACTGTGTCTTTCTC	0.512000													8	12					3.09899e-07	3.74293e-07	1	1	0
PRDM9	56979	broad.mit.edu	37	5	23526979	23526979	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:23526979C>A	ENST00000296682.3	+	11	1964	c.1782C>A	c.(1780-1782)gtC>gtA	p.V594V		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	594					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GGCAGTCAGTCCTCCTCACTC	0.587000										HNSCC(3;0.000094)			34	101					2.36135e-34	4.11761e-34	1	1	0
SAMSN1	64092	broad.mit.edu	37	21	15884770	15884770	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr21:15884770G>T	ENST00000285670.2	-	5	782	c.608C>A	c.(607-609)tCa>tAa	p.S203*	SAMSN1_ENST00000400564.1_Intron|SAMSN1_ENST00000400566.1_Nonsense_Mutation_p.S135*	NM_001256370.1	NP_001243299.1	Q9NSI8	SAMN1_HUMAN	SAM domain, SH3 domain and nuclear localization signals 1	135	SH3.				negative regulation of adaptive immune response|negative regulation of B cell activation|negative regulation of peptidyl-tyrosine phosphorylation	cytoplasm|nucleus|ruffle	phosphotyrosine binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	24				Epithelial(23;0.000155)|COAD - Colon adenocarcinoma(22;0.00118)|Colorectal(24;0.00961)|Lung(58;0.164)		CTTACTTGATGAGCTCTGTCC	0.453000													71	170					7.31121e-38	1.28696e-37	1	1	0
DGKI	9162	broad.mit.edu	37	7	137076038	137076038	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:137076038G>A	ENST00000453654.1	-	33	2672	c.2133C>T	c.(2131-2133)gaC>gaT	p.D711D	DGKI_ENST00000494390.1_5'UTR|DGKI_ENST00000288490.5_Silent_p.D1042D|DGKI_ENST00000424189.2_Silent_p.D1055D|DGKI_ENST00000446122.1_Silent_p.D1024D			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	1042					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						AAGCAGCCAAGTCTGGGTCCC	0.468000													22	48					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124377301	124377301	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:124377301G>A	ENST00000360013.3	+	42	6184	c.6057G>A	c.(6055-6057)gtG>gtA	p.V2019V	KALRN_ENST00000428018.2_Silent_p.V290V|KALRN_ENST00000291478.4_Silent_p.V322V|KALRN_ENST00000393496.1_Silent_p.V360V|KALRN_ENST00000459915.1_Silent_p.V111V	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2018	DH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						ACATCTACGTGTGGTATTGTC	0.522000													19	98					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62845424	62845424	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:62845424C>A	ENST00000512091.1	+	17	3492	c.2745C>A	c.(2743-2745)aaC>aaA	p.N915K	LPHN3_ENST00000514157.1_Missense_Mutation_p.N915K|LPHN3_ENST00000545650.1_Missense_Mutation_p.N915K|LPHN3_ENST00000507164.1_Missense_Mutation_p.N983K|LPHN3_ENST00000506746.1_Missense_Mutation_p.N983K|LPHN3_ENST00000511324.1_Missense_Mutation_p.N983K|LPHN3_ENST00000506700.1_Missense_Mutation_p.N915K|LPHN3_ENST00000506720.1_Missense_Mutation_p.N983K|LPHN3_ENST00000514996.1_Missense_Mutation_p.N915K|LPHN3_ENST00000508946.1_Missense_Mutation_p.N915K|LPHN3_ENST00000507625.1_Missense_Mutation_p.N983K|LPHN3_ENST00000504896.1_Missense_Mutation_p.N915K|LPHN3_ENST00000509896.1_Missense_Mutation_p.N983K|LPHN3_ENST00000508693.1_Missense_Mutation_p.N983K|LPHN3_ENST00000514591.1_Missense_Mutation_p.N915K			Q9HAR2	LPHN3_HUMAN	latrophilin 3	902			L -> V.		neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TCCACAAGAACCTCTGCATCA	0.463000													33	191					3.21399e-22	5.30594e-22	1	1	0
GPCPD1	56261	broad.mit.edu	37	20	5566845	5566845	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:5566845G>A	ENST00000379019.4	-	5	514	c.302C>T	c.(301-303)cCt>cTt	p.P101L		NM_019593.3	NP_062539.1	Q9NPB8	GPCP1_HUMAN	glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae)	101	CBM20.				glycerol metabolic process|lipid metabolic process		carbohydrate binding|glycerophosphodiester phosphodiesterase activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(2)|skin(1)	16						CATACCTAAAGGGGTTATTGA	0.368000													15	168					0	0	1	0	0
TSPAN11	441631	broad.mit.edu	37	12	31116783	31116783	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:31116783C>A	ENST00000261177.9	+	3	166	c.107C>A	c.(106-108)gCt>gAt	p.A36D	TSPAN11_ENST00000544427.1_Missense_Mutation_p.A26D|TSPAN11_ENST00000546076.1_Missense_Mutation_p.A36D|TSPAN11_ENST00000535215.1_5'UTR	NM_001080509.2	NP_001073978.1	A1L157	TSN11_HUMAN	tetraspanin 11	36						integral to membrane				endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)	11	all_lung(12;3.11e-10)|Lung NSC(12;5.24e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Lung SC(12;0.0592)|Esophageal squamous(101;0.233)					GCCGTCCTGGCTGTGGGCATC	0.667000													19	93					4.35082e-09	5.6198e-09	1	1	0
SERPINE3	647174	broad.mit.edu	37	13	51918540	51918540	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr13:51918540A>T	ENST00000524365.1	+	5	1034	c.409A>T	c.(409-411)Agc>Tgc	p.S137C	SERPINE3_ENST00000400389.4_Missense_Mutation_p.S137C|SERPINE3_ENST00000521255.1_Missense_Mutation_p.S137C			A8MV23	SERP3_HUMAN	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3	137					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)	2						GTGGGCTAACAGCAGCCTGGA	0.582000													7	13					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140237350	140237350	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:140237350G>A	ENST00000307360.5	+	1	1717	c.1717G>A	c.(1717-1719)Ggc>Agc	p.G573S	PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCAGCGCGGGCGGTGCAGT	0.677000													20	25					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124862806	124862806	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:124862806T>A	ENST00000356219.3	-	19	2299	c.2144A>T	c.(2143-2145)gAg>gTg	p.E715V	NCOR2_ENST00000429285.2_Missense_Mutation_p.E714V|NCOR2_ENST00000404621.1_Missense_Mutation_p.E714V|NCOR2_ENST00000404121.2_Missense_Mutation_p.E285V|NCOR2_ENST00000397355.1_Missense_Mutation_p.E715V|NCOR2_ENST00000405201.1_Missense_Mutation_p.E715V	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	715					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CACCATCTCCTCCTCATTTCC	0.657000													17	178					0	0	1	0	0
CAPN2	824	broad.mit.edu	37	1	223949949	223949949	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:223949949G>T	ENST00000295006.5	+	14	1937	c.1628G>T	c.(1627-1629)gGa>gTa	p.G543V	CAPN2_ENST00000433674.2_Missense_Mutation_p.G465V|CAPN2_ENST00000474026.1_3'UTR	NM_001748.4	NP_001739.2	P17655	CAN2_HUMAN	calpain 2, (m/II) large subunit	543	Domain IV.				proteolysis	cytoplasm|plasma membrane				breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|stomach(3)	29				GBM - Glioblastoma multiforme(131;0.109)		CAGTTGGCAGGAGAGGTAAAT	0.483000													16	72					2.89027e-11	3.97234e-11	1	1	0
GPR123	84435	broad.mit.edu	37	10	134909203	134909203	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:134909203C>A	ENST00000607359.1	+	11	2082	c.2082C>A	c.(2080-2082)gtC>gtA	p.V694V	GPR123_ENST00000392607.3_Intron			Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	0						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		AGGGCCTCGTCTTGGCTGGAC	0.647000													7	20					0.00448238	0.00475507	1	1	0
GNAI1	2770	broad.mit.edu	37	7	79828541	79828541	+	Splice_Site	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:79828541G>C	ENST00000351004.3	+	4	677	c.303_splice	c.e4-1	p.D102_splice	GNAI1_ENST00000457358.2_Splice_Site_p.D50_splice	NM_002069.5	NP_002060.4	P63096	GNAI1_HUMAN	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	102					cell cycle|cell division|inhibition of adenylate cyclase activity by G-protein signaling pathway|platelet activation|synaptic transmission	centrosome|heterotrimeric G-protein complex|midbody|nucleus	G-protein beta/gamma-subunit complex binding|GTP binding|metabotropic serotonin receptor binding|signal transducer activity			NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	19						GAATGTTCAGGATGATGCACG	0.383000													9	60					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237713891	237713891	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:237713891G>T	ENST00000366574.2	+	27	3431	c.3114G>T	c.(3112-3114)ctG>ctT	p.L1038L	RYR2_ENST00000542537.1_Silent_p.L1022L|RYR2_ENST00000360064.6_Silent_p.L1036L	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1038	4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ACACTCTTCTGGATGACCGAA	0.517000													3	22					0.014758	0.0153924	1	1	0
CMPK2	129607	broad.mit.edu	37	2	6991757	6991757	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:6991757C>A	ENST00000256722.5	-	4	1049	c.1050G>T	c.(1048-1050)caG>caT	p.Q350H	CMPK2_ENST00000458098.1_Intron|CMPK2_ENST00000478738.1_5'UTR|CMPK2_ENST00000404168.1_Missense_Mutation_p.Q350H	NM_207315.3	NP_997198.2	Q5EBM0	CMPK2_HUMAN	cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial	350					dTDP biosynthetic process	mitochondrion	ATP binding|cytidylate kinase activity|thymidylate kinase activity|UMP kinase activity			large_intestine(1)|lung(13)|prostate(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					GGGGCAGGTGCTGGAGACCCC	0.582000													28	113					5.8336e-16	8.7977e-16	1	1	0
STXBP5L	9515	broad.mit.edu	37	3	120941999	120941999	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:120941999C>G	ENST00000273666.6	+	11	1377	c.1106C>G	c.(1105-1107)cCa>cGa	p.P369R	STXBP5L_ENST00000471454.1_Missense_Mutation_p.P369R|STXBP5L_ENST00000472879.1_Missense_Mutation_p.P369R|STXBP5L_ENST00000492541.1_Missense_Mutation_p.P369R|STXBP5L_ENST00000497029.1_Missense_Mutation_p.P369R	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	369					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		ACGCCCTATCCAAATGGTAAG	0.294000													8	44					0	0	1	0	0
SIGLEC15	284266	broad.mit.edu	37	18	43422117	43422117	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr18:43422117C>A	ENST00000389474.3	+	6	1169	c.952C>A	c.(952-954)Ccc>Acc	p.P318T	SIGLEC15_ENST00000546268.1_Missense_Mutation_p.P164T|SIGLEC15_ENST00000602118.2_3'UTR	NM_213602.2	NP_998767.1	Q6ZMC9	SIG15_HUMAN	sialic acid binding Ig-like lectin 15	318						integral to membrane				endometrium(1)|large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)	4						CCAGATGAACCCCCGGAGCCC	0.537000													27	79					1.22384e-17	1.91826e-17	1	1	0
PLEKHA7	144100	broad.mit.edu	37	11	16812604	16812604	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:16812604C>A	ENST00000355661.3	-	20	2898	c.2888G>T	c.(2887-2889)aGg>aTg	p.R963M	PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000531066.1_Missense_Mutation_p.R963M|PLEKHA7_ENST00000448080.2_Missense_Mutation_p.R964M|PLEKHA7_ENST00000332954.4_5'UTR			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	963					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						GTCTCGCTTCCTCTCGTCTGA	0.657000													34	82					1.22674e-20	1.99569e-20	1	1	0
BOD1L1	259282	broad.mit.edu	37	4	13603927	13603927	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:13603927C>A	ENST00000040738.5	-	10	4732	c.4597G>T	c.(4597-4599)Gtg>Ttg	p.V1533L		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	1533							DNA binding										CCAGCCTTCACTGGACTTAAG	0.502000													12	20					4.3838e-07	5.28328e-07	1	1	0
ZNF226	7769	broad.mit.edu	37	19	44679175	44679175	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:44679175G>T	ENST00000300823.6	+	6	410	c.274G>T	c.(274-276)Gct>Tct	p.A92S	ZNF226_ENST00000413984.2_Missense_Mutation_p.A92S|ZNF226_ENST00000590089.1_Intron|ZNF226_ENST00000588742.1_Missense_Mutation_p.A92S|ZNF226_ENST00000337433.5_Intron|ZNF226_ENST00000588883.1_3'UTR|ZNF226_ENST00000454662.2_Intron	NM_001146220.2|NM_015919.3	NP_001139692.1|NP_057003.2	Q9NYT6	ZN226_HUMAN	zinc finger protein 226	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						Prostate(69;0.0352)|all_neural(266;0.202)				CTATGACCTGGCTCAAACTTA	0.338000													9	74					5.16669e-11	7.04893e-11	1	1	0
ZFYVE9	9372	broad.mit.edu	37	1	52810614	52810614	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:52810614C>A	ENST00000287727.3	+	18	4286	c.4114C>A	c.(4114-4116)Cag>Aag	p.Q1372K	ZFYVE9_ENST00000357206.2_Missense_Mutation_p.Q1313K|ZFYVE9_ENST00000371591.1_Missense_Mutation_p.Q1372K	NM_004799.2	NP_004790.2	O95405	ZFYV9_HUMAN	zinc finger, FYVE domain containing 9	1372					endocytosis|SMAD protein complex assembly|SMAD protein import into nucleus|transforming growth factor beta receptor signaling pathway	early endosome membrane	metal ion binding|protein binding|receptor activity|serine-type peptidase activity			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	53						TGACTCAGATCAGGTATGATG	0.468000													24	81					3.6726e-16	5.56878e-16	1	1	0
KIF4B	285643	broad.mit.edu	37	5	154395286	154395286	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:154395286C>A	ENST00000435029.4	+	1	2027	c.1867C>A	c.(1867-1869)Ctg>Atg	p.L623M		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	623					axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			GTCCAAACTTCTGAAACTAAA	0.458000													4	109					0.014758	0.0153924	1	1	0
PCDHGA8	9708	broad.mit.edu	37	5	140773411	140773411	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:140773411G>T	ENST00000398604.2	+	1	1031	c.1031G>T	c.(1030-1032)aGa>aTa	p.R344I	PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA5_ENST00000518069.1_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATGACAATAGACCAGAAGTG	0.428000													55	164					5.82218e-30	9.99623e-30	1	1	0
KIAA1324L	222223	broad.mit.edu	37	7	86548627	86548627	+	Splice_Site	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:86548627C>A	ENST00000450689.2	-	11	1585		c.e11-1		KIAA1324L_ENST00000416314.1_Splice_Site|KIAA1324L_ENST00000297222.6_Splice_Site|KIAA1324L_ENST00000490995.1_Splice_Site|KIAA1324L_ENST00000444627.1_Splice_Site	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like							integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					ACCTCCCAACCTAGAAGTAAT	0.333000													18	65					2.4624e-09	3.21032e-09	1	1	0
FCGBP	8857	broad.mit.edu	37	19	40362933	40362933	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:40362933C>T	ENST00000221347.6	-	32	15144	c.15137G>A	c.(15136-15138)aGc>aAc	p.S5046N		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	5046	VWFD 12.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGCCTCGTTGCTCTCATAGGG	0.687000													10	56					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11631206	11631206	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:11631206C>T	ENST00000262442.3	+	28	5849	c.5781C>T	c.(5779-5781)atC>atT	p.I1927I	DNAH9_ENST00000454412.2_Silent_p.I1927I	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1927	AAA 1 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TTAATCGAATCTCCGTGGAGG	0.478000													10	44					0	0	1	0	0
MYOZ2	51778	broad.mit.edu	37	4	120072050	120072050	+	Missense_Mutation	SNP	A	A	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:120072050A>C	ENST00000307128.5	+	3	313	c.100A>C	c.(100-102)Aaa>Caa	p.K34Q		NM_016599.4	NP_057683.1	Q9NPC6	MYOZ2_HUMAN	myozenin 2	34							protein phosphatase 2B binding			endometrium(1)|large_intestine(6)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	16						GGACCTGGGCAAAAAGGTCAG	0.368000													14	74					0	0	1	0	0
TGS1	96764	broad.mit.edu	37	8	56723481	56723481	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:56723481C>T	ENST00000260129.5	+	11	2662	c.2185C>T	c.(2185-2187)Cgc>Tgc	p.R729C		NM_024831.6	NP_079107.6	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase 1	729	Sufficient for catalytic activity.				cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			TGCCCTTGCTCGCAATAATGC	0.358000													9	305					0	0	1	0	0
ENPP7	339221	broad.mit.edu	37	17	77709420	77709420	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:77709420G>T	ENST00000328313.5	+	3	1199	c.978G>T	c.(976-978)agG>agT	p.R326S		NM_178543.3	NP_848638.2	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 7	326					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(6)|skin(3)	34			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			ACAACCCCAGGGTCACACCCC	0.632000													4	77					1	1	1	1	0
KRT6B	3854	broad.mit.edu	37	12	52841082	52841082	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:52841082G>A	ENST00000252252.3	-	9	1634	c.1587C>T	c.(1585-1587)tcC>tcT	p.S529S		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	529	Tail.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		TGCCGCTGCTGGAACTAAAGC	0.622000													4	83					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196726541	196726541	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:196726541T>C	ENST00000312428.6	-	42	7736	c.7636A>G	c.(7636-7638)Aaa>Gaa	p.K2546E		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2546	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AAGAAAGATTTGGATAAATCT	0.358000													3	50					0	0	1	0	0
TRAV12-3	28672	broad.mit.edu	37	14	22434160	22434160	+	RNA	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr14:22434160C>T	ENST00000390442.3	+	0	269																											TGCTGATGTACACATACTCCA	0.438000													28	213					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5410323	5410323	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:5410323C>A	ENST00000399537.4	-	11	4250	c.3902G>T	c.(3901-3903)gGg>gTg	p.G1301V	TNRC18_ENST00000430969.1_Missense_Mutation_p.G1301V			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1301							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CTGTCCCTCCCCGGCGGGCAC	0.672000													12	26					6.53275e-17	1.01258e-16	1	1	0
MICAL1	64780	broad.mit.edu	37	6	109773801	109773801	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:109773801G>C	ENST00000368952.4	-	5	936	c.646C>G	c.(646-648)Cag>Gag	p.Q216E	MICAL1_ENST00000358807.3_Missense_Mutation_p.Q197E|MICAL1_ENST00000358577.3_Missense_Mutation_p.Q197E			Q8TDZ2	MICA1_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 1	197					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		GGTTGGAGCTGGGCACGCCAG	0.542000													4	22					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15936685	15936685	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:15936685G>T	ENST00000504595.1	+	4	1347	c.866G>T	c.(865-867)gGc>gTc	p.G289V	FBXL7_ENST00000329673.7_Missense_Mutation_p.G277V|FBXL7_ENST00000510662.1_Missense_Mutation_p.G242V	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	289					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						GAGGACGAAGGCCTGCACACC	0.617000													14	54					1.5739e-10	2.12134e-10	1	1	0
ZFYVE28	57732	broad.mit.edu	37	4	2306730	2306730	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:2306730C>T	ENST00000290974.2	-	8	1676	c.1337G>A	c.(1336-1338)gGg>gAg	p.G446E	ZFYVE28_ENST00000515312.1_Missense_Mutation_p.G376E|ZFYVE28_ENST00000511071.1_Missense_Mutation_p.G416E|RP11-478C1.7_ENST00000510632.1_RNA	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	446					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding	p.G446V(2)		NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						CAAGCTGATCCCCGCCGCTCC	0.692000													25	69					0	0	1	0	0
SNX29	92017	broad.mit.edu	37	16	12146024	12146024	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:12146024G>T	ENST00000566228.1	+	8	1138	c.1069G>T	c.(1069-1071)Gtg>Ttg	p.V357L		NM_032167.3	NP_115543.3	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	0	PX.				cell communication		phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	7						CGAAGATGACGTGTATGGAAA	0.493000													20	57					8.34094e-07	9.94496e-07	1	1	0
ANKRD28	23243	broad.mit.edu	37	3	15726906	15726906	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:15726906C>G	ENST00000399451.2	-	21	2493	c.2126G>C	c.(2125-2127)gGt>gCt	p.G709A	ANKRD28_ENST00000383777.1_Missense_Mutation_p.G742A|ANKRD28_ENST00000497037.1_5'UTR	NM_001195098.1|NM_001195099.1|NM_015199.3	NP_001182027.1|NP_001182028.1|NP_056014.2	O15084	ANR28_HUMAN	ankyrin repeat domain 28	709						nucleoplasm	protein binding			breast(2)|endometrium(1)|large_intestine(2)|prostate(1)	6						GCACTTAGCACCATGTTGAAG	0.443000													8	210					0	0	1	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125686318	125686318	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:125686318G>T	ENST00000371126.1	-	1	516	c.274C>A	c.(274-276)Ctg>Atg	p.L92M		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	92										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						CCCAGCTCCAGTTGGCGCTCC	0.662000													46	40					1.21353e-23	2.02135e-23	1	1	0
DLGAP3	58512	broad.mit.edu	37	1	35370233	35370233	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:35370233C>A	ENST00000373347.1	-	3	1020	c.752G>T	c.(751-753)gGg>gTg	p.G251V	DLGAP3_ENST00000235180.4_Missense_Mutation_p.G251V			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	251					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				CTGGTGCCGCCCATCCCCCTT	0.657000													61	132					4.493e-44	7.95903e-44	1	1	0
SLC17A1	6568	broad.mit.edu	37	6	25819737	25819737	+	Splice_Site	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:25819737A>T	ENST00000244527.4	-	5	645		c.e5+1		SLC17A1_ENST00000476801.1_Splice_Site|SLC17A1_ENST00000468082.1_Splice_Site|SLC17A1_ENST00000427328.1_Splice_Site	NM_005074.3	NP_005065.2	Q14916	NPT1_HUMAN	solute carrier family 17 (organic anion transporter), member 1						sodium ion transport|urate metabolic process	integral to plasma membrane|membrane fraction	sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(14)|ovary(3)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	36						TTAATTCTTTACCTGATGTAC	0.408000													23	78					0	0	1	0	0
SPATA7	55812	broad.mit.edu	37	14	88895776	88895776	+	Nonsense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr14:88895776A>T	ENST00000556553.1	+	8	1460	c.901A>T	c.(901-903)Aag>Tag	p.K301*	SPATA7_ENST00000356583.5_Nonsense_Mutation_p.K301*|SPATA7_ENST00000045347.7_Nonsense_Mutation_p.K333*|SPATA7_ENST00000393545.4_Nonsense_Mutation_p.K333*			Q9P0W8	SPAT7_HUMAN	spermatogenesis associated 7	333					response to stimulus|visual perception					cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	18						GGATGAGATTAAGGATGATGC	0.373000													14	42					0	0	1	0	0
NSUN2	54888	broad.mit.edu	37	5	6600086	6600086	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:6600086C>G	ENST00000264670.6	-	19	2568	c.2257G>C	c.(2257-2259)Gac>Cac	p.D753H	NSUN2_ENST00000539938.1_Missense_Mutation_p.D517H|NSUN2_ENST00000506139.1_Missense_Mutation_p.D718H	NM_017755.5	NP_060225.4	Q08J23	NSUN2_HUMAN	NOP2/Sun RNA methyltransferase family, member 2	753						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	41						GCTGTCACGTCTGGACTGTTG	0.637000													8	157					0	0	1	0	0
ABCA5	23461	broad.mit.edu	37	17	67303001	67303001	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:67303001C>A	ENST00000392676.3	-	6	717	c.653G>T	c.(652-654)cGa>cTa	p.R218L	ABCA5_ENST00000392677.2_Missense_Mutation_p.R218L|ABCA5_ENST00000588877.1_Missense_Mutation_p.R218L			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	218					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					AATTACTCCTCGGGGAAAGGT	0.323000													16	56					5.03518e-11	6.88635e-11	1	1	0
PCDHB12	56124	broad.mit.edu	37	5	140590252	140590252	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:140590252G>T	ENST00000239450.2	+	1	1962	c.1773G>T	c.(1771-1773)gcG>gcT	p.A591A	PCDHB12_ENST00000541609.1_Silent_p.A254A	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		591	Cadherin 6.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGTGGTGGCGGTGGACGGTG	0.706000													18	366					7.92952e-12	1.10894e-11	1	1	0
IGKV3D-11	28876	broad.mit.edu	37	2	90212124	90212124	+	RNA	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:90212124C>T	ENST00000390277.2	+	0	313																											ATGATGCATCCAACAGGGCCA	0.577000													13	132					0	0	1	0	0
TMX2	51075	broad.mit.edu	37	11	57507689	57507689	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:57507689C>T	ENST00000278422.4	+	8	875	c.863C>T	c.(862-864)tCa>tTa	p.S288L	TMX2_ENST00000378312.4_Missense_Mutation_p.S250L|TMX2-CTNND1_ENST00000528395.1_Intron	NM_015959.3	NP_057043.1	Q9Y320	TMX2_HUMAN	thioredoxin-related transmembrane protein 2	288					cell redox homeostasis	integral to membrane				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(1)|urinary_tract(2)	12						ACCACAGTGTCAGATGGGGAA	0.483000													16	39					0	0	1	0	0
ZNF423	23090	broad.mit.edu	37	16	49670418	49670418	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:49670418G>A	ENST00000561648.1	-	4	2698	c.2645C>T	c.(2644-2646)tCg>tTg	p.S882L	ZNF423_ENST00000567169.1_Missense_Mutation_p.S765L|ZNF423_ENST00000563137.2_Missense_Mutation_p.S822L|ZNF423_ENST00000562871.1_Missense_Mutation_p.S822L|ZNF423_ENST00000262383.2_Missense_Mutation_p.S882L|ZNF423_ENST00000562520.1_Missense_Mutation_p.S822L|ZNF423_ENST00000535559.1_Missense_Mutation_p.S765L	NM_001271620.1	NP_001258549.1	Q2M1K9	ZN423_HUMAN	zinc finger protein 423	882					cell differentiation|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(16)|lung(47)|ovary(1)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	89		all_cancers(37;0.0155)				CATGGGCTCCGACGCGTCCAC	0.627000													25	69					0	0	1	0	0
LINC00477	144360	broad.mit.edu	37	12	24736745	24736745	+	RNA	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:24736745C>T	ENST00000483544.1	-	0	357					NR_029451.2																						AAAAAAAAATCCACCAGGAGG	0.567000													4	30					0	0	1	0	0
RP11-640M9.2	0	broad.mit.edu	37	1	144598647	144598647	+	RNA	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:144598647G>A	ENST00000419820.1	+	0	575																											TCCACGCTGGGGGTGCCACCA	0.587000													4	44					0	0	1	0	0
TPSD1	23430	broad.mit.edu	37	16	1306312	1306312	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:1306312C>T	ENST00000211076.3	+	1	179	c.31C>T	c.(31-33)Ctg>Ttg	p.L11L	TPSD1_ENST00000397534.2_Silent_p.L4L	NM_012217.2	NP_036349.1	Q9BZJ3	TRYD_HUMAN	tryptase delta 1	11					proteolysis	extracellular region	serine-type endopeptidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)	20		Hepatocellular(780;0.00369)				GATGCTGAGCCTGCTGCTGCT	0.687000													36	150					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91132556	91132556	+	Silent	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:91132556A>G	ENST00000373094.1	+	2	2162	c.1317A>G	c.(1315-1317)gcA>gcG	p.A439A	PCDH11X_ENST00000406881.1_Silent_p.A439A|PCDH11X_ENST00000373097.1_Silent_p.A439A|PCDH11X_ENST00000395337.2_Silent_p.A439A|PCDH11X_ENST00000361655.2_Silent_p.A439A|PCDH11X_ENST00000504220.1_Silent_p.A439A|PCDH11X_ENST00000361724.1_Silent_p.A439A|PCDH11X_ENST00000373088.1_Silent_p.A439A|PCDH11X_ENST00000298274.8_Silent_p.A439A	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	439	Cadherin 4.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						TACTGGCTGCAGATGCTGGCA	0.413000													3	58					0	0	1	0	0
WRAP53	55135	broad.mit.edu	37	17	7606724	7606724	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:7606724C>G	ENST00000316024.5	+	10	3915	c.1567C>G	c.(1567-1569)Cca>Gca	p.P523A	WRAP53_ENST00000431639.2_Missense_Mutation_p.P523A|WRAP53_ENST00000534050.1_Missense_Mutation_p.P490A|WRAP53_ENST00000396463.2_Missense_Mutation_p.P523A|WRAP53_ENST00000457584.2_Missense_Mutation_p.P523A			Q9BUR4	WAP53_HUMAN	WD repeat containing, antisense to TP53	523					positive regulation of telomerase activity|telomere formation via telomerase	Cajal body|cytoplasm|telomerase holoenzyme complex	protein binding|RNA binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|stomach(2)	18						TGGGGGGGCGCCAGACTCCAG	0.582000													3	65					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120476554	120476554	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:120476554G>T	ENST00000355622.6	+	3	2249	c.2148G>T	c.(2146-2148)gtG>gtT	p.V716V	TLR4_ENST00000472304.1_3'UTR|TLR4_ENST00000394487.4_Silent_p.V676V	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	716	TIR.				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						TTCCCGGTGTGGCCATTGCTG	0.478000													21	66					6.44725e-10	8.54529e-10	1	1	0
RALYL	138046	broad.mit.edu	37	8	85441657	85441657	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:85441657A>G	ENST00000521268.1	+	2	1206	c.101A>G	c.(100-102)aAg>aGg	p.K34R	RALYL_ENST00000518566.1_Missense_Mutation_p.K34R|RALYL_ENST00000521695.1_Missense_Mutation_p.K34R|RALYL_ENST00000522455.1_Missense_Mutation_p.K34R|RALYL_ENST00000517638.1_Missense_Mutation_p.K47R	NM_173848.5	NP_776247.3	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like	34	RRM.						identical protein binding|nucleotide binding|RNA binding			endometrium(2)|kidney(2)|large_intestine(6)|lung(13)|ovary(1)	24						GCAATTGTCAAGAAAGTTGAC	0.403000													9	37					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197898254	197898254	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:197898254C>T	ENST00000367390.3	+	6	1059	c.1032C>T	c.(1030-1032)ctC>ctT	p.L344L	LHX9_ENST00000337020.2_Intron|LHX9_ENST00000367391.1_Intron|LHX9_ENST00000367387.4_Silent_p.L353L|LHX9_ENST00000561173.1_Intron	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	353					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						GCGGAGCTCTCACTCCACCCG	0.562000													16	144					0	0	1	0	0
DZIP1	22873	broad.mit.edu	37	13	96237027	96237027	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr13:96237027G>T	ENST00000347108.3	-	20	2919	c.2487C>A	c.(2485-2487)gcC>gcA	p.A829A	DZIP1_ENST00000361156.3_Silent_p.A810A|DZIP1_ENST00000376829.2_Silent_p.A829A|DZIP1_ENST00000361396.2_Silent_p.A810A			Q86YF9	DZIP1_HUMAN	DAZ interacting zinc finger protein 1	829					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(20)|lung(11)|ovary(2)|pancreas(1)|skin(1)|stomach(1)	38	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			ATGCGCCCCAGGCATTTAGCA	0.428000													11	90					0.00136819	0.00147385	1	1	0
OR14A16	284532	broad.mit.edu	37	1	247978917	247978917	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:247978917C>A	ENST00000357627.1	-	1	114	c.115G>T	c.(115-117)Ggg>Tgg	p.G39W		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						AGGACATTCCCCATCAGGGCA	0.378000													8	69					0.00448238	0.00475507	1	1	0
OR52N4	390072	broad.mit.edu	37	11	5776267	5776267	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:5776267C>G	ENST00000317254.3	+	1	345	c.297C>G	c.(295-297)tgC>tgG	p.C99W	TRIM5_ENST00000380027.1_Intron	NM_001005175.2	NP_001005175.3	Q8NGI2	O52N4_HUMAN	olfactory receptor, family 52, subfamily N, member 4 (gene/pseudogene)	99					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;1.87e-10)|LUSC - Lung squamous cell carcinoma(625;0.114)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.197)		TTGATGAATGCCTTGTCCAGA	0.483000													6	111					0	0	1	0	0
PXDC1	221749	broad.mit.edu	37	6	3723971	3723971	+	Splice_Site	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:3723971C>G	ENST00000380283.4	-	5	1073		c.e5-1		PXDC1_ENST00000477592.2_Splice_Site	NM_183373.3	NP_899229.2	Q5TGL8	CF145_HUMAN	PX domain containing 1						cell communication		phosphatidylinositol binding										ATTCTCAAATCTGAAATTAGA	0.537000													9	42					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22362821	22362821	+	Nonsense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:22362821A>T	ENST00000397121.2	-	3	2015	c.1698T>A	c.(1696-1698)tgT>tgA	p.C566*		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	566					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AAGCTTTGCCACATTCTTCAC	0.378000													6	56					0	0	1	0	0
ADAMTS14	140766	broad.mit.edu	37	10	72518015	72518015	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:72518015T>C	ENST00000373208.1	+	21	3161	c.3161T>C	c.(3160-3162)cTa>cCa	p.L1054P	ADAMTS14_ENST00000373207.1_Missense_Mutation_p.L1051P	NM_139155.2	NP_631894.2	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 14	1051					collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(15)|ovary(7)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50						TCTGAACCCCTACATCCCATT	0.547000													3	52					0	0	1	0	0
STOM	2040	broad.mit.edu	37	9	124111469	124111469	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:124111469T>A	ENST00000286713.2	-	5	471	c.454A>T	c.(454-456)Agg>Tgg	p.R152W	STOM_ENST00000538954.1_Missense_Mutation_p.R101W|STOM_ENST00000347359.2_Intron	NM_004099.4	NP_004090.4	P27105	STOM_HUMAN	stomatin	152					protein homooligomerization	cytoskeleton|integral to plasma membrane|melanosome|membrane raft	protein binding			endometrium(1)|large_intestine(1)|lung(3)|urinary_tract(1)	6				OV - Ovarian serous cystadenocarcinoma(323;0.00107)|GBM - Glioblastoma multiforme(294;0.0137)		AGAACATTCCTCAGAGTAGTT	0.498000													29	51					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40980875	40980875	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:40980875G>C	ENST00000373198.3	-	10	1846	c.1611C>G	c.(1609-1611)agC>agG	p.S537R	PTPRT_ENST00000373187.1_Missense_Mutation_p.S537R|PTPRT_ENST00000373193.3_Missense_Mutation_p.S537R|PTPRT_ENST00000373201.1_Missense_Mutation_p.S537R|PTPRT_ENST00000356100.2_Missense_Mutation_p.S537R|PTPRT_ENST00000373184.1_Missense_Mutation_p.S537R|PTPRT_ENST00000373190.1_Missense_Mutation_p.S537R	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	537	Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TCCCCCTCTGGCTCGAGAGGT	0.527000													38	88					0	0	1	0	0
JAK2	3717	broad.mit.edu	37	9	5072599	5072599	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:5072599G>T	ENST00000381652.3	+	13	2243	c.1749G>T	c.(1747-1749)ctG>ctT	p.L583L	JAK2_ENST00000539801.1_Silent_p.L583L|JAK2_ENST00000544510.1_Silent_p.L434L	NM_004972.3	NP_004963.1	O60674	JAK2_HUMAN	Janus kinase 2	583	Protein kinase 1.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)|ETV6/JAK2(11)|PCM1/JAK2(30)|PAX5/JAK2(18)	breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(32944)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(4)|skin(2)|urinary_tract(1)	32998	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		TAAAAGTTCTGGATAAAGCAC	0.373000		1	"""T, Mis, O"""	"""ETV6, PCM1, BCR"""	"""ALL, AML, MPD,  CML"""				Polycythemia Vera, Familial				8	29					2.17888e-05	2.50683e-05	1	1	0
ZNF445	353274	broad.mit.edu	37	3	44488777	44488777	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:44488777C>G	ENST00000425708.2	-	7	2727	c.2386G>C	c.(2386-2388)Ggg>Cgg	p.G796R	ZNF445_ENST00000396077.2_Missense_Mutation_p.G796R			P59923	ZN445_HUMAN	zinc finger protein 445	796					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|skin(3)	31				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		AAGGCTTTCCCACACTCCCTG	0.463000													3	19					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2029134	2029134	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:2029134G>T	ENST00000382203.1	+	2	321	c.112G>T	c.(112-114)Ggt>Tgt	p.G38C	SMARCA2_ENST00000357248.2_Missense_Mutation_p.G38C|SMARCA2_ENST00000349721.2_Missense_Mutation_p.G38C|SMARCA2_ENST00000382194.1_Missense_Mutation_p.G38C			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	38					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		ACCATCCCCAGGTTCCGTCCA	0.642000													8	11					0.0477658	0.0492667	1	1	0
AHNAK	79026	broad.mit.edu	37	11	62302641	62302641	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:62302641G>A	ENST00000378024.4	-	4	450	c.176C>T	c.(175-177)aCc>aTc	p.T59I	AHNAK_ENST00000257247.7_Missense_Mutation_p.T59I|AHNAK_ENST00000530124.1_Missense_Mutation_p.T59I	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	59	PDZ.				nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				AAAGTAGATGGTGGCACCCAC	0.622000													14	42					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61511598	61511598	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:61511598G>C	ENST00000266070.4	-	16	6035	c.5710C>G	c.(5710-5712)Cga>Gga	p.R1904G	DIDO1_ENST00000395343.1_Missense_Mutation_p.R1904G	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1904	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GGGCCGCCTCGGGGGCCTTTC	0.622000													16	43					0	0	1	0	0
EMILIN3	90187	broad.mit.edu	37	20	39992362	39992362	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:39992362C>A	ENST00000332312.3	-	3	622	c.430G>T	c.(430-432)Gag>Tag	p.E144*		NM_052846.1	NP_443078.1	Q9NT22	EMIL3_HUMAN	elastin microfibril interfacer 3	144						proteinaceous extracellular matrix				biliary_tract(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|prostate(2)|skin(3)|urinary_tract(2)	30		Myeloproliferative disorder(115;0.00425)				GGCTCAGGCTCCAGCTGGGGT	0.657000													23	72					3.01185e-09	3.89933e-09	1	1	0
SLC35G3	146861	broad.mit.edu	37	17	33520735	33520735	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:33520735G>T	ENST00000297307.5	-	1	677	c.592C>A	c.(592-594)Ctg>Atg	p.L198M		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	198						integral to membrane											AGGCCTCCCAGGAAAGCCTCC	0.597000													29	119					2.65835e-16	4.05289e-16	1	1	0
SLIT3	6586	broad.mit.edu	37	5	168100236	168100236	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:168100236C>T	ENST00000519560.1	-	33	4206	c.3787G>A	c.(3787-3789)Ggg>Agg	p.G1263R	SLIT3_ENST00000404867.3_Missense_Mutation_p.G1263R|SLIT3_ENST00000332966.8_Missense_Mutation_p.G1270R	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1263	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TGGAGCTTCCCCAGGCTCTTT	0.557000													39	75					0	0	1	0	0
BCR	613	broad.mit.edu	37	22	23626286	23626286	+	Splice_Site	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr22:23626286G>A	ENST00000305877.8	+	9	2988		c.e9+1		BCR_ENST00000359540.3_Splice_Site	NM_004327.3	NP_004318.3	P11274	BCR_HUMAN	breakpoint cluster region						regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	35						AGAGCGGAGGGTGAGTGACGA	0.617000			T	"""ABL1,  FGFR1, JAK2 """	"""CML, ALL, AML"""								3	30					0	0	1	0	0
BTAF1	9044	broad.mit.edu	37	10	93711298	93711298	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:93711298C>T	ENST00000265990.6	+	5	847	c.539C>T	c.(538-540)tCa>tTa	p.S180L		NM_003972.2	NP_003963.1	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa	180					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(2)|urinary_tract(6)	59		Colorectal(252;0.0846)				ACCCCAACTTCAGCATCCTTT	0.318000													23	128					0	0	1	0	0
CHKB	1120	broad.mit.edu	37	22	51018814	51018814	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr22:51018814C>T	ENST00000406938.2	-	6	926	c.709G>A	c.(709-711)Gtc>Atc	p.V237I	CHKB_ENST00000463053.1_5'UTR	NM_005198.4	NP_005189.2	Q9Y259	CHKB_HUMAN	choline kinase beta	237					phosphatidylethanolamine biosynthetic process		ATP binding|choline kinase activity|ethanolamine kinase activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(5)|ovary(3)|skin(1)|urinary_tract(1)	15		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;4.04e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.79e-74)|Epithelial(4;6.17e-70)|GBM - Glioblastoma multiforme(4;5.68e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.205)	Choline(DB00122)	TGGCAGAAGACGACTGGCGAT	0.547000													4	158					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145039601	145039601	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:145039601C>A	ENST00000313382.9	-	1	401	c.9G>T	c.(7-9)caG>caT	p.Q3H	PDE4DIP_ENST00000369359.4_Intron|PDE4DIP_ENST00000530740.1_Intron|PDE4DIP_ENST00000369348.3_Intron|PDE4DIP_ENST00000478649.2_Missense_Mutation_p.Q3H|PDE4DIP_ENST00000493130.2_Missense_Mutation_p.Q3H	NM_001198832.1	NP_001185761.1	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TCGTCCAGGTCTGCTCCATTT	0.617000			T	PDGFRB	MPD								5	117					0.00307968	0.00327951	1	1	0
TBX3	6926	broad.mit.edu	37	12	115118728	115118728	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:115118728G>T	ENST00000349155.2	-	2	1576	c.613C>A	c.(613-615)Cac>Aac	p.H205N	TBX3_ENST00000257566.3_Missense_Mutation_p.H205N	NM_005996.3	NP_005987.3	O15119	TBX3_HUMAN	T-box 3	205					anterior/posterior axis specification, embryo|anti-apoptosis|cell aging|embryonic arm morphogenesis|embryonic digit morphogenesis|female genitalia development|follicle-stimulating hormone secretion|luteinizing hormone secretion|male genitalia development|mesoderm morphogenesis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle|positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter|skeletal system development	nucleus	sequence-specific DNA binding			breast(5)|endometrium(1)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	47	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0574)		TTCAGTTTGTGGAAAGTGACG	0.473000													42	149					5.39261e-20	8.72196e-20	1	1	0
HEATR5A	25938	broad.mit.edu	37	14	31849705	31849705	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr14:31849705C>A	ENST00000543095.2	-	11	1860	c.1676G>T	c.(1675-1677)gGa>gTa	p.G559V	HEATR5A_ENST00000439727.1_Missense_Mutation_p.G266V|HEATR5A_ENST00000439348.1_Missense_Mutation_p.G553V|HEATR5A_ENST00000404677.3_Missense_Mutation_p.G559V|HEATR5A_ENST00000389961.3_Missense_Mutation_p.G553V	NM_015473.3	NP_056288.2	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	553							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)	26	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		CAGCAACCATCCAGCTTGTGT	0.378000													7	26					0.307466	0.309686	1	1	0
ARSH	347527	broad.mit.edu	37	X	2942079	2942079	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:2942079C>A	ENST00000381130.2	+	6	919	c.919C>A	c.(919-921)Ctg>Atg	p.L307M		NM_001011719.1	NP_001011719.1	Q5FYA8	ARSH_HUMAN	arylsulfatase family, member H	307						integral to membrane	arylsulfatase activity|metal ion binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(6)|lung(13)|skin(1)|stomach(1)	34		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				CCTGGATGCCCTGGACCAGGA	0.547000													12	14					0.000308642	0.000338354	1	1	0
MAP1B	4131	broad.mit.edu	37	5	71496161	71496161	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:71496161T>A	ENST00000296755.7	+	5	7277	c.6979T>A	c.(6979-6981)Tct>Act	p.S2327T		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	2327						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TGCCAATGCCTCTGCATCCAA	0.502000													13	158					0	0	1	0	0
LDHA	3939	broad.mit.edu	37	11	18422524	18422524	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:18422524C>T	ENST00000422447.3	+	4	658	c.385C>T	c.(385-387)Ccg>Tcg	p.P129S	LDHA_ENST00000540430.1_Missense_Mutation_p.P158S|LDHA_ENST00000396222.2_Missense_Mutation_p.P129S|LDHA_ENST00000379412.5_Missense_Mutation_p.P129S|LDHA_ENST00000227157.4_Missense_Mutation_p.P129S|LDHA_ENST00000430553.2_Intron|LDHA_ENST00000542179.1_Missense_Mutation_p.P129S	NM_001135239.1|NM_005566.3	NP_001128711.1|NP_005557.1	P00338	LDHA_HUMAN	lactate dehydrogenase A	129					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)|endometrium(1)|large_intestine(4)|lung(4)	12					NADH(DB00157)	AAAATACAGCCCGAACTGCAA	0.378000													6	73					0	0	1	0	0
CDHR3	222256	broad.mit.edu	37	7	105660897	105660897	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:105660897G>C	ENST00000542731.1	+	13	1840	c.1732G>C	c.(1732-1734)Gat>Cat	p.D578H	CDHR3_ENST00000470188.1_Intron|CDHR3_ENST00000343407.5_Intron|CDHR3_ENST00000317716.9_Missense_Mutation_p.D578H|CDHR3_ENST00000478080.1_Missense_Mutation_p.D490H			Q6ZTQ4	CDHR3_HUMAN	cadherin-related family member 3	578	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|cervix(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)	23						CCTCCCAGTGGATCTGAAAGT	0.433000													4	61					0	0	1	0	0
AMELY	266	broad.mit.edu	37	Y	6736195	6736195	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrY:6736195G>T	ENST00000215479.5	-	5	523	c.456C>A	c.(454-456)ccC>ccA	p.P152P	AMELY_ENST00000383037.4_Silent_p.P166P|AMELY_ENST00000383036.1_Silent_p.P166P	NM_001143.1	NP_001134.1	Q99218	AMELY_HUMAN	amelogenin, Y-linked	166	Gln-rich.				biomineral tissue development	proteinaceous extracellular matrix	structural constituent of tooth enamel			NS(1)|lung(5)	6						GTGGCAGCAGGGGCTGCATGG	0.647000													15	9					2.37509e-13	3.41572e-13	1	1	0
LDB3	11155	broad.mit.edu	37	10	88466390	88466390	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:88466390G>A	ENST00000361373.4	+	7	1020	c.999G>A	c.(997-999)tcG>tcA	p.S333S	LDB3_ENST00000458213.2_Intron|LDB3_ENST00000352360.5_Intron|LDB3_ENST00000263066.6_Intron|LDB3_ENST00000429277.2_Intron	NM_007078.2	NP_009009.1	O75112	LDB3_HUMAN	LIM domain binding 3	333						cytoskeleton|perinuclear region of cytoplasm|pseudopodium	zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|soft_tissue(1)	25						GTGCGGCTTCGCCACCCCTGG	0.687000													22	73					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155724193	155724193	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:155724193C>A	ENST00000437809.1	-	28	5726	c.5604G>T	c.(5602-5604)agG>agT	p.R1868S	GON4L_ENST00000271883.5_Missense_Mutation_p.R1868S|GON4L_ENST00000368331.1_Missense_Mutation_p.R1868S			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	1868					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TACAGCTCCGCCTTTTGCTCT	0.527000													21	217					1.77063e-15	2.64883e-15	1	1	0
COL21A1	81578	broad.mit.edu	37	6	55925587	55925587	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:55925587C>A	ENST00000244728.5	-	27	2756	c.2359G>T	c.(2359-2361)Gag>Tag	p.E787*	COL21A1_ENST00000370808.2_Nonsense_Mutation_p.E187*|COL21A1_ENST00000535941.1_Nonsense_Mutation_p.E787*|COL21A1_ENST00000370819.1_Nonsense_Mutation_p.E784*|COL21A1_ENST00000467045.1_5'UTR	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	787					cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			TCTGAAAACTCTCTTCCCTGC	0.299000													18	53					4.7796e-09	6.13108e-09	1	1	0
PLAC1	10761	broad.mit.edu	37	X	133700442	133700442	+	Missense_Mutation	SNP	T	T	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:133700442T>G	ENST00000359237.4	-	3	556	c.271A>C	c.(271-273)Atg>Ctg	p.M91L	PLAC1_ENST00000476971.1_5'UTR	NM_021796.3	NP_068568.1	Q9HBJ0	PLAC1_HUMAN	placenta-specific 1	91					placenta development	extracellular region				large_intestine(4)|lung(1)|pancreas(1)	6	Acute lymphoblastic leukemia(192;0.000127)					TAGATAACCATGTCCTGAGAG	0.537000													9	118					0	0	1	0	0
IGSF11	152404	broad.mit.edu	37	3	118824037	118824037	+	Translation_Start_Site	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:118824037C>T	ENST00000354673.2	-	3	383	c.3G>A	c.(1-3)atG>atA	p.M1I	IGSF11_ENST00000425327.2_Start_Codon_SNP_p.M1I|IGSF11_ENST00000441144.2_Start_Codon_SNP_p.M1I	NM_152538.2	NP_689751.2	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11	0					cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						CCACCAGAGACATTTATTCTT	0.323000													11	29					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039132	11039132	+	RNA	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr21:11039132C>T	ENST00000470054.1	-	0	1071									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTCCTCAGGACATAATGAAGT	0.403000													9	301					0	0	1	0	0
ENOPH1	58478	broad.mit.edu	37	4	83381180	83381180	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:83381180G>T	ENST00000273920.3	+	6	961	c.693G>T	c.(691-693)gtG>gtT	p.V231V	ENOPH1_ENST00000509635.1_Silent_p.V143V	NM_021204.3	NP_067027.1	Q9UHY7	ENOPH_HUMAN	enolase-phosphatase 1	231					L-methionine salvage from methylthioadenosine	cytoplasm|nucleus	2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity|2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity|acireductone synthase activity|magnesium ion binding|phosphoglycolate phosphatase activity	p.V231V(1)		central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|skin(1)	13						CTGTGGTGGTGAGACCAGGCA	0.473000													18	62					2.37509e-13	3.41572e-13	1	1	0
THSD7A	221981	broad.mit.edu	37	7	11485751	11485751	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:11485751G>C	ENST00000423059.3	-	13	3252	c.3001C>G	c.(3001-3003)Caa>Gaa	p.Q1001E	AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1001	TSP type-1 10.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		GCCATTGCTTGGTAACGATAT	0.413000										HNSCC(18;0.044)			63	207					0	0	1	0	0
BLMH	642	broad.mit.edu	37	17	28612480	28612480	+	Nonsense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:28612480G>A	ENST00000261714.6	-	6	745	c.571C>T	c.(571-573)Cga>Tga	p.R191*	BLMH_ENST00000582669.1_5'UTR|BLMH_ENST00000394819.3_Nonsense_Mutation_p.R104*	NM_000386.3	NP_000377.1	Q13867	BLMH_HUMAN	bleomycin hydrolase	191					proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|stomach(1)	13						TTCCGCAGTCGTATACAGAAT	0.413000													4	63					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55494118	55494118	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:55494118C>T	ENST00000543010.1	+	6	1195	c.1052C>T	c.(1051-1053)cCg>cTg	p.P351L	NLRP2_ENST00000263437.6_Missense_Mutation_p.P348L|NLRP2_ENST00000448584.2_Missense_Mutation_p.P351L|NLRP2_ENST00000339757.7_Missense_Mutation_p.P329L|NLRP2_ENST00000538819.1_Missense_Mutation_p.P327L|NLRP2_ENST00000391721.4_Missense_Mutation_p.P327L|NLRP2_ENST00000427260.2_Missense_Mutation_p.P328L|NLRP2_ENST00000537859.1_Missense_Mutation_p.P329L	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	351	NACHT.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GCGGAGGAGCCGATCTACATA	0.617000													3	18					0	0	1	0	0
HELZ	9931	broad.mit.edu	37	17	65103614	65103614	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:65103614T>A	ENST00000358691.5	-	31	5078	c.4912A>T	c.(4912-4914)Agc>Tgc	p.S1638C	HELZ_ENST00000580168.1_Missense_Mutation_p.S1639C	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					ATGTCTCTGCTGTTATCATTA	0.488000													12	130					0	0	1	0	0
PREB	10113	broad.mit.edu	37	2	27355120	27355120	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:27355120C>T	ENST00000260643.2	-	6	1157	c.904G>A	c.(904-906)Gtc>Atc	p.V302I	PREB_ENST00000406567.3_Intron	NM_013388.4	NP_037520.1	Q9HCU5	PREB_HUMAN	prolactin regulatory element binding	302					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane|nucleus	DNA binding|guanyl-nucleotide exchange factor activity|protein binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGGAGACGACTTCATGGCCA	0.617000													18	207					0	0	1	0	0
PIK3R2	5296	broad.mit.edu	37	19	18278101	18278101	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:18278101G>C	ENST00000593731.1	+	13	2281	c.1721G>C	c.(1720-1722)cGa>cCa	p.R574P	PIK3R2_ENST00000222254.7_Missense_Mutation_p.R574P			O00459	P85B_HUMAN	phosphoinositide-3-kinase, regulatory subunit 2 (beta)	574					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|negative regulation of anti-apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|T cell costimulation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	GTPase activator activity|phosphatidylinositol 3-kinase regulator activity|protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(12)|ovary(3)|pancreas(1)|stomach(1)	24						CGCAAGATCCGAGACCAGTAC	0.607000													5	73					0	0	1	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44218851	44218851	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:44218851G>C	ENST00000371554.1	+	7	1238	c.1024G>C	c.(1024-1026)Gac>Cac	p.D342H	HSP90AB1_ENST00000371646.5_Missense_Mutation_p.D342H|HSP90AB1_ENST00000353801.3_Missense_Mutation_p.D342H			P08238	HS90B_HUMAN	heat shock protein 90kDa alpha (cytosolic), class B member 1	342					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(12)|prostate(2)|skin(2)|urinary_tract(2)	33	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GGCTCCCTTTGACCTTTTTGA	0.408000													19	146					0	0	1	0	0
CD84	8832	broad.mit.edu	37	1	160523821	160523821	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:160523821C>A	ENST00000368054.3	-	3	539	c.504G>T	c.(502-504)tgG>tgT	p.W168C	CD84_ENST00000534968.1_Missense_Mutation_p.W54C|CD84_ENST00000311224.4_Missense_Mutation_p.W168C|RP11-528G1.2_ENST00000446952.1_RNA|CD84_ENST00000368047.3_5'UTR|CD84_ENST00000368048.3_Missense_Mutation_p.W168C|CD84_ENST00000368051.3_Missense_Mutation_p.W168C	NM_003874.3	NP_003865.1	Q9UIB8	SLAF5_HUMAN	CD84 molecule	168	Ig-like C2-type.				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(1)	24	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CCAGGGGACTCCAATTGTATG	0.448000													9	82					0.00621372	0.00655435	1	1	0
CDK12	51755	broad.mit.edu	37	17	37673787	37673787	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:37673787C>T	ENST00000447079.4	+	10	2974	c.2941C>T	c.(2941-2943)Cgt>Tgt	p.R981C	CDK12_ENST00000430627.2_Missense_Mutation_p.R981C	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	981	Protein kinase.				mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						ATATCGAAGGCGTCTACGAGA	0.473000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			13	59					0	0	1	0	0
ANKRD1	27063	broad.mit.edu	37	10	92680081	92680081	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:92680081C>T	ENST00000371697.3	-	2	300	c.52G>A	c.(52-54)Ggg>Agg	p.G18R		NM_014391.2	NP_055206.2	Q15327	ANKR1_HUMAN	ankyrin repeat domain 1 (cardiac muscle)	18					cellular lipid metabolic process|defense response|signal transduction		DNA binding	p.G18W(1)		autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(10)|prostate(3)|skin(1)	27		Colorectal(252;0.0475)				CCTGCCTCCCCATTGCCATTC	0.507000													93	279					0	0	1	0	0
NXPH2	11249	broad.mit.edu	37	2	139428595	139428595	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:139428595A>T	ENST00000272641.3	-	2	798	c.692T>A	c.(691-693)aTt>aAt	p.I231N		NM_007226.2	NP_009157.1	O95156	NXPH2_HUMAN	neurexophilin 2	231	V (Cys-rich).				neuropeptide signaling pathway	extracellular region				endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(3)|skin(3)|urinary_tract(3)	22				BRCA - Breast invasive adenocarcinoma(221;0.101)		GTAAATGCAAATGACCTTGAA	0.458000													8	28					0	0	1	0	0
XPNPEP1	7511	broad.mit.edu	37	10	111646061	111646061	+	Nonsense_Mutation	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:111646061T>A	ENST00000369680.4	-	8	810	c.562A>T	c.(562-564)Aaa>Taa	p.K188*	XPNPEP1_ENST00000369683.1_Nonsense_Mutation_p.K117*|XPNPEP1_ENST00000322238.8_Nonsense_Mutation_p.K231*|XPNPEP1_ENST00000430337.1_5'UTR|XPNPEP1_ENST00000502935.1_Nonsense_Mutation_p.K231*	NM_020383.3	NP_065116.3	Q9NQW7	XPP1_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	188					bradykinin catabolic process|proteolysis		manganese ion binding|metalloaminopeptidase activity|protein homodimerization activity			endometrium(2)|kidney(9)|large_intestine(4)|lung(9)|ovary(3)|pancreas(2)|skin(1)|urinary_tract(1)	31		Breast(234;0.174)		Epithelial(162;1.64e-05)|all cancers(201;0.000564)|BRCA - Breast invasive adenocarcinoma(275;0.0721)		TCAGCCATTTTCAACCGAAGG	0.512000													13	41					0	0	1	0	0
PCDHGB4	8641	broad.mit.edu	37	5	140768315	140768315	+	Silent	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:140768315C>G	ENST00000519479.1	+	1	864	c.864C>G	c.(862-864)acC>acG	p.T288T	PCDHGA7_ENST00000518325.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron	NM_003736.2|NM_018925.2|NM_032098.1	NP_003727.1|NP_061748.1|NP_115269.1														endometrium(9)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|prostate(1)|stomach(3)|urinary_tract(2)	37			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCAGATCACCCAATTTGACC	0.453000													11	69					0	0	1	0	0
TTC26	79989	broad.mit.edu	37	7	138831963	138831963	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:138831963G>T	ENST00000464848.1	+	6	552	c.472G>T	c.(472-474)Gcc>Tcc	p.A158S	TTC26_ENST00000343187.4_Missense_Mutation_p.A127S|TTC26_ENST00000481482.1_3'UTR|TTC26_ENST00000474035.2_Missense_Mutation_p.A158S|TTC26_ENST00000495038.1_Intron|TTC26_ENST00000478836.2_Intron|TTC26_ENST00000430935.1_Missense_Mutation_p.A158S			A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26	158							binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	24						ACTCAGTTTGGCCTCAATCCA	0.373000													17	68					1.99824e-07	2.43986e-07	1	1	0
MLLT4-AS1	653483	broad.mit.edu	37	6	168226591	168226591	+	RNA	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:168226591C>A	ENST00000359760.5	-	0	798					NR_027906.1																						CCCTGCTGAGCCTAGCACCGC	0.721000													57	182					1.43161e-34	2.5042e-34	1	1	0
PNLIPRP3	119548	broad.mit.edu	37	10	118215251	118215251	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:118215251C>A	ENST00000369230.3	+	5	620	c.474C>A	c.(472-474)tcC>tcA	p.S158S		NM_001011709.2	NP_001011709.2	Q17RR3	LIPR3_HUMAN	pancreatic lipase-related protein 3	158					lipid catabolic process	extracellular region	triglyceride lipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(29)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	50				all cancers(201;0.0131)		TTGAATATTCCCCTTCTAAAG	0.373000													10	76					0.000151284	0.000168161	1	1	0
KIF2B	84643	broad.mit.edu	37	17	51900785	51900785	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:51900785C>A	ENST00000268919.4	+	1	547	c.391C>A	c.(391-393)Ctg>Atg	p.L131M		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	131					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						AGGGGACAGCCTGGATGTGAG	0.577000													27	80					1.50538e-07	1.85023e-07	1	1	0
UGT8	7368	broad.mit.edu	37	4	115544483	115544483	+	Silent	SNP	T	T	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:115544483T>C	ENST00000310836.6	+	2	969	c.447T>C	c.(445-447)caT>caC	p.H149H	UGT8_ENST00000394511.3_Silent_p.H149H	NM_001128174.1	NP_001121646.1	Q16880	CGT_HUMAN	UDP glycosyltransferase 8	149					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		TGATAGCTCATCTTTTAGGGG	0.453000													4	116					0	0	1	0	0
MAATS1	89876	broad.mit.edu	37	3	119466053	119466053	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:119466053C>A	ENST00000273390.5	+	15	2071	c.1994C>A	c.(1993-1995)gCa>gAa	p.A665E	RP11-169N13.4_ENST00000489428.2_RNA	NM_033364.3	NP_203528.2			MYCBP-associated, testis expressed 1																		CAAGCCAGGGCAGAAATAGAG	0.403000													4	89					0.150653	0.153123	1	1	0
ITGAD	3681	broad.mit.edu	37	16	31408780	31408780	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:31408780C>G	ENST00000389202.2	+	3	287	c.238C>G	c.(238-240)Cac>Gac	p.H80D		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	80					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CATCCCGCTGCACAGTGAGTG	0.647000													3	10					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121647881	121647881	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:121647881A>T	ENST00000489711.1	+	16	1782	c.1394A>T	c.(1393-1395)cAc>cTc	p.H465L	SLC15A2_ENST00000465060.1_3'UTR|SLC15A2_ENST00000295605.2_Missense_Mutation_p.H434L	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	465					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding	p.H465R(1)		NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	CAGGATTTTCACTTCCACCTG	0.398000													19	188					0	0	1	0	0
ESX1	80712	broad.mit.edu	37	X	103494998	103494998	+	Missense_Mutation	SNP	T	T	A	rs11267975		TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:103494998T>A	ENST00000372588.4	-	4	1215	c.1132A>T	c.(1132-1134)Agg>Tgg	p.R378W		NM_153448.3	NP_703149.1	Q8N693	ESX1_HUMAN	ESX homeobox 1	378	15 X 9 AA tandem repeats of P-P-x-x-P-x- P-P-x.				negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(10)|lung(12)|ovary(1)|skin(2)	27						ACATGTGACCTGGGTGGCAGA	0.632000													15	16					0	0	1	0	0
ZNF292	23036	broad.mit.edu	37	6	87964708	87964708	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:87964708G>T	ENST00000369577.3	+	8	1404	c.1361G>T	c.(1360-1362)cGa>cTa	p.R454L	ZNF292_ENST00000339907.4_Missense_Mutation_p.R449L	NM_015021.1	NP_055836.1	O60281	ZN292_HUMAN	zinc finger protein 292	454					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(27)|lung(21)|ovary(4)|prostate(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	89		all_cancers(76;3.82e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.17e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.31e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0199)		ACCTTGAAACGACAATGTCTT	0.368000													11	45					3.27435e-08	4.17144e-08	1	1	0
GRM8	2918	broad.mit.edu	37	7	126086302	126086302	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:126086302C>A	ENST00000339582.2	-	10	3363	c.2555G>T	c.(2554-2556)cGc>cTc	p.R852L	GRM8_ENST00000444921.2_Missense_Mutation_p.R852L|GRM8_ENST00000358373.3_Missense_Mutation_p.R852L			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	852					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	GCTCCTCTTGCGTTTTTGAAC	0.423000										HNSCC(24;0.065)			16	77					7.07596e-05	7.99268e-05	1	1	0
PIGG	54872	broad.mit.edu	37	4	501300	501300	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:501300G>T	ENST00000453061.2	+	4	783	c.677G>T	c.(676-678)gGg>gTg	p.G226V	PIGG_ENST00000536264.1_Missense_Mutation_p.G104V|PIGG_ENST00000509768.1_Missense_Mutation_p.G137V|PIGG_ENST00000310340.5_Missense_Mutation_p.G226V|PIGG_ENST00000504346.1_Missense_Mutation_p.G137V|PIGG_ENST00000503111.1_Missense_Mutation_p.G137V|PIGG_ENST00000383028.4_Intron|PIGG_ENST00000296306.7_Missense_Mutation_p.G137V	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	226					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						CACATTTCAGGGCCCAACAGC	0.517000													7	50					0.00307968	0.00327951	1	1	0
MYH13	8735	broad.mit.edu	37	17	10216544	10216544	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:10216544T>A	ENST00000418404.3	-	29	4275	c.4112A>T	c.(4111-4113)gAg>gTg	p.E1371V	MYH13_ENST00000570743.1_Missense_Mutation_p.E1371V|MYH13_ENST00000252172.4_Missense_Mutation_p.E1371V			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	1371					muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						CTGGGCAACCTCACTGTTGGC	0.627000													78	239					0	0	1	0	0
CACNA2D1	781	broad.mit.edu	37	7	81603859	81603859	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:81603859G>T	ENST00000356860.3	-	25	2303	c.1965C>A	c.(1963-1965)tgC>tgA	p.C655*	CACNA2D1_ENST00000356253.5_Nonsense_Mutation_p.C667*	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	667						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	TCAGGTCATTGCAGTAATCTC	0.254000													6	15					2.0095e-06	2.37563e-06	1	1	0
PCDHA2	56146	broad.mit.edu	37	5	140176336	140176336	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:140176336C>A	ENST00000526136.1	+	1	1787	c.1787C>A	c.(1786-1788)gCa>gAa	p.A596E	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000378132.1_Missense_Mutation_p.A596E|PCDHA2_ENST00000520672.2_Missense_Mutation_p.A596E	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGGTGCGCGCAGTGGACGCT	0.672000													21	107					8.10497e-08	1.0209e-07	1	1	0
SNHG14	104472715	broad.mit.edu	37	15	25457044	25457044	+	RNA	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr15:25457044G>C	ENST00000424208.1	+	0	2516				SNHG14_ENST00000424333.1_RNA|SNHG14_ENST00000450809.1_RNA	NR_003305.1																						GAGAAATTTGGAGGAGGATGC	0.507000													6	211					0	0	1	0	0
ZNF585B	92285	broad.mit.edu	37	19	37676193	37676193	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:37676193C>A	ENST00000532828.2	-	5	2497	c.2246G>T	c.(2245-2247)gGc>gTc	p.G749V	ZNF585B_ENST00000527838.1_3'UTR|ZNF585B_ENST00000531805.1_Missense_Mutation_p.G694V|CTC-454I21.3_ENST00000585860.2_Intron|ZNF585B_ENST00000312908.5_Missense_Mutation_p.G337V	NM_152279.3	NP_689492.3	Q52M93	Z585B_HUMAN	zinc finger protein 585B	749					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CCCACAGATGCCACACTTGTA	0.488000													43	127					6.20943e-19	9.92798e-19	1	1	0
CYTL1	54360	broad.mit.edu	37	4	5021099	5021099	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:5021099G>T	ENST00000307746.4	-	1	100	c.74C>A	c.(73-75)cCg>cAg	p.P25Q		NM_018659.2	NP_061129.1	Q9NRR1	CYTL1_HUMAN	cytokine-like 1	25					signal transduction	extracellular space|soluble fraction	receptor binding			breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		GTAGCAGGTCGGGGGAGTGGG	0.736000													3	7					0.150653	0.153123	1	1	0
ZNF287	57336	broad.mit.edu	37	17	16469845	16469845	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:16469845C>A	ENST00000395824.1	-	3	1112	c.495G>T	c.(493-495)gtG>gtT	p.V165V	ZNF287_ENST00000395825.3_Silent_p.V165V			Q9HBT7	ZN287_HUMAN	zinc finger protein 287	158	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(5)|prostate(1)|urinary_tract(1)	20				UCEC - Uterine corpus endometrioid carcinoma (92;0.083)		TCACTTTGGTCACCAAGTCAT	0.463000													28	77					2.61193e-14	3.86594e-14	1	1	0
HGF	3082	broad.mit.edu	37	7	81388090	81388090	+	Silent	SNP	T	T	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:81388090T>C	ENST00000222390.5	-	3	511	c.285A>G	c.(283-285)caA>caG	p.Q95Q	HGF_ENST00000423064.2_Silent_p.Q95Q|HGF_ENST00000453411.1_Silent_p.Q95Q|HGF_ENST00000457544.2_Silent_p.Q95Q|HGF_ENST00000453018.1_5'UTR|HGF_ENST00000354224.6_Silent_p.Q95Q|HGF_ENST00000444829.2_Silent_p.Q95Q	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	95	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						ACCAGAGGCATTGTTTTCTTG	0.338000													15	67					0	0	1	0	0
ALS2	57679	broad.mit.edu	37	2	202614485	202614485	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:202614485C>A	ENST00000264276.6	-	8	2137	c.1765G>T	c.(1765-1767)Ggt>Tgt	p.G589C		NM_020919.3	NP_065970.2	Q96Q42	ALS2_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	589					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						CCAAGTTGACCAAAGGTATTG	0.378000													8	73					0.00136819	0.00147385	1	1	0
TAS1R2	80834	broad.mit.edu	37	1	19166641	19166641	+	Missense_Mutation	SNP	C	C	T	rs145202761		TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:19166641C>T	ENST00000375371.3	-	6	1993	c.1972G>A	c.(1972-1974)Gcc>Acc	p.A658T		NM_152232.2	NP_689418.2	Q8TE23	TS1R2_HUMAN	taste receptor, type 1, member 2	658					detection of chemical stimulus involved in sensory perception of sweet taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(10)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(3)|stomach(1)	45		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00466)|BRCA - Breast invasive adenocarcinoma(304;3.56e-05)|Kidney(64;0.000177)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	Aspartame(DB00168)	ATCTTGAAGGCGCAGACGATC	0.587000													25	144					0	0	1	0	0
NDNF	79625	broad.mit.edu	37	4	121958168	121958168	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:121958168T>C	ENST00000379692.4	-	4	1484	c.958A>G	c.(958-960)Aac>Gac	p.N320D		NM_024574.3	NP_078850.3	Q8TB73	CD031_HUMAN	neuron-derived neurotrophic factor	320	Fibronectin type-III 1.									breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|prostate(3)|skin(1)|urinary_tract(1)	29						ATGTTGCTGTTGATGTTGACC	0.428000													12	73					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116631983	116631983	+	Silent	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:116631983C>G	ENST00000395715.3	-	3	919	c.342G>C	c.(340-342)ccG>ccC	p.P114P	TRPS1_ENST00000519076.1_Intron|TRPS1_ENST00000220888.5_Silent_p.P101P|TRPS1_ENST00000519674.1_Silent_p.P101P|TRPS1_ENST00000520276.1_Silent_p.P105P	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	101					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CCTCATCATGCGGAAAGGAGG	0.498000									Langer-Giedion syndrome				48	60					0	0	1	0	0
TERF2	7014	broad.mit.edu	37	16	69404452	69404452	+	Silent	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:69404452G>C	ENST00000254942.3	-	5	790	c.774C>G	c.(772-774)acC>acG	p.T258T	TERF2_ENST00000603068.1_Silent_p.T216T|TERF2_ENST00000569611.2_5'UTR|TERF2_ENST00000567296.2_Silent_p.T258T	NM_005652.3	NP_005643.2	Q15554	TERF2_HUMAN	telomeric repeat binding factor 2	216					age-dependent telomere shortening|cell cycle|cellular senescence|negative regulation of telomere maintenance via semi-conservative replication|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|regulation of transcription, DNA-dependent|telomeric loop formation	Golgi apparatus|nuclear telomere cap complex|nucleoplasm	double-stranded telomeric DNA binding|protein C-terminus binding|protein homodimerization activity			NS(2)|breast(1)|large_intestine(3)|lung(1)	7		Ovarian(137;0.101)				TCTGCTGGAAGGTCTCATATG	0.498000													10	56					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	51995080	51995080	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:51995080G>T	ENST00000291707.3	-	8	1658	c.1603C>A	c.(1603-1605)Ccc>Acc	p.P535T	SIGLEC12_ENST00000598614.1_Missense_Mutation_p.P417T	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	535					cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TCAATCAGGGGTCCCTGAATG	0.612000													14	25					5.01169e-05	5.69557e-05	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141115658	141115658	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:141115658C>A	ENST00000389484.3	-	74	12256	c.11285G>T	c.(11284-11286)tGt>tTt	p.C3762F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3762	LDL-receptor class A 32.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATCCTTTTTACAAGGCCTTGC	0.383000										TSP Lung(27;0.18)			18	77					2.98393e-07	3.63545e-07	1	1	0
ZNF229	7772	broad.mit.edu	37	19	44932550	44932550	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:44932550C>T	ENST00000291187.4	-	6	2710	c.2388G>A	c.(2386-2388)ggG>ggA	p.G796G	ZNF229_ENST00000588931.1_Silent_p.G802G|CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000591289.1_Intron	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	802					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				TGAAGCCTTTCCCACACACAC	0.493000													25	50					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237713890	237713890	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:237713890T>C	ENST00000366574.2	+	27	3430	c.3113T>C	c.(3112-3114)cTg>cCg	p.L1038P	RYR2_ENST00000542537.1_Missense_Mutation_p.L1022P|RYR2_ENST00000360064.6_Missense_Mutation_p.L1036P	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	1038	4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TACACTCTTCTGGATGACCGA	0.512000													3	22					0	0	1	0	0
CPXM2	119587	broad.mit.edu	37	10	125521564	125521564	+	Nonsense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:125521564C>T	ENST00000241305.3	-	11	1755	c.1601G>A	c.(1600-1602)tGg>tAg	p.W534*	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	534					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CTGCGTCTTCCAGGGGGACCG	0.647000													43	156					0	0	1	0	0
LPIN3	64900	broad.mit.edu	37	20	39978466	39978466	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:39978466C>T	ENST00000373257.3	+	6	782	c.691C>T	c.(691-693)Cgg>Tgg	p.R231W		NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	231					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				GCTGGAGGTGCGGACCCCGGA	0.642000													4	82					0	0	1	0	0
ZNF559	84527	broad.mit.edu	37	19	9451817	9451817	+	Missense_Mutation	SNP	A	A	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:9451817A>C	ENST00000393883.2	+	5	848	c.200A>C	c.(199-201)cAg>cCg	p.Q67P	ZNF559_ENST00000538743.1_5'UTR|ZNF177_ENST00000541595.2_Intron|ZNF559_ENST00000585352.1_Missense_Mutation_p.Q67P|ZNF177_ENST00000605471.1_Intron|ZNF559_ENST00000317221.7_Missense_Mutation_p.Q67P|ZNF177_ENST00000446085.4_Intron|ZNF559_ENST00000603380.1_Missense_Mutation_p.Q67P|ZNF559_ENST00000592896.1_Missense_Mutation_p.Q95P|ZNF177_ENST00000602856.1_Intron|ZNF177_ENST00000602738.1_Intron|ZNF559_ENST00000586255.1_Missense_Mutation_p.Q95P|ZNF559_ENST00000587557.1_Missense_Mutation_p.Q131P|ZNF559_ENST00000592504.1_Missense_Mutation_p.Q67P	NM_001202412.1	NP_001189341.1	Q9BR84	ZN559_HUMAN	zinc finger protein 559	67	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|large_intestine(7)|lung(15)|ovary(1)|urinary_tract(1)	26						TCAGCACCTCAGCAGAATTTT	0.328000													13	69					0	0	1	0	0
PURB	5814	broad.mit.edu	37	7	44924337	44924337	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:44924337G>A	ENST00000395699.2	-	1	623	c.611C>T	c.(610-612)cCg>cTg	p.P204L		NM_033224.3	NP_150093.1	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	204	Gly-rich.				regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding			large_intestine(2)|lung(3)|prostate(1)|skin(1)	7						gccgcctcccgggccgccTGC	0.701000													5	17					0	0	1	0	0
C17orf82	388407	broad.mit.edu	37	17	59489513	59489513	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:59489513C>A	ENST00000335108.2	+	1	402	c.177C>A	c.(175-177)agC>agA	p.S59R		NM_203425.1	NP_982249.1	Q86X59	CQ082_HUMAN	chromosome 17 open reading frame 82	59										cervix(1)|lung(1)	2						GGAGGCCGAGCGCTCCCTGCT	0.731000											OREG0024630	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	20					0.00198382	0.0021247	1	1	0
KPRP	448834	broad.mit.edu	37	1	152733087	152733087	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:152733087G>C	ENST00000368773.1	+	2	1081	c.1023G>C	c.(1021-1023)caG>caC	p.Q341H	KPRP_ENST00000606109.1_Missense_Mutation_p.Q341H	NM_001025231.1	NP_001020402.1	Q5T749	KPRP_HUMAN	keratinocyte proline-rich protein	341	Pro-rich.					cytoplasm				NS(1)|breast(1)|endometrium(9)|kidney(1)|large_intestine(10)|lung(21)|ovary(6)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTCCCCCACAGAGGTGTCCTG	0.657000													4	89					0	0	1	0	0
LRRC32	2615	broad.mit.edu	37	11	76372200	76372200	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:76372200C>A	ENST00000407242.2	-	3	679	c.437G>T	c.(436-438)gGg>gTg	p.G146V	LRRC32_ENST00000464145.1_Intron|AP001189.4_ENST00000447519.1_RNA|LRRC32_ENST00000260061.5_Missense_Mutation_p.G146V|LRRC32_ENST00000404995.1_Missense_Mutation_p.G146V	NM_005512.2	NP_005503.1	Q14392	LRC32_HUMAN	leucine rich repeat containing 32	146						integral to plasma membrane				endometrium(1)|large_intestine(3)|lung(26)|upper_aerodigestive_tract(1)	31						GGGTGCCTCCCCCAGCAGCCG	0.677000													18	40					3.99206e-14	5.87749e-14	1	1	0
LECT1	11061	broad.mit.edu	37	13	53313202	53313202	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr13:53313202G>T	ENST00000448904.2	-	2	287	c.177C>A	c.(175-177)atC>atA	p.I59I	LECT1_ENST00000377962.3_Silent_p.I59I	NM_001011705.1|NM_007015.2	NP_001011705.1|NP_008946.1	O75829	LECT1_HUMAN	leukocyte cell derived chemotaxin 1	59					cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|urinary_tract(1)	15		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)		AGAAGGCCCCGATGGCCCCAA	0.687000													8	14					7.48243e-07	8.95965e-07	1	1	0
GALNT8	26290	broad.mit.edu	37	12	4829957	4829957	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:4829957G>T	ENST00000252318.2	+	1	451	c.114G>T	c.(112-114)acG>acT	p.T38T	RP11-234B24.6_ENST00000544741.2_Intron	NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	38						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						ACCTGTTTACGGGTGGTCTCC	0.488000													31	61					1.30998e-17	2.04754e-17	1	1	0
OTUD7B	56957	broad.mit.edu	37	1	149921568	149921568	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:149921568C>A	ENST00000369135.3	-	9	1381	c.1087G>T	c.(1087-1089)Gtg>Ttg	p.V363L		NM_020205.2	NP_064590.2	Q6GQQ9	OTU7B_HUMAN	OTU domain containing 7B	363	Catalytic.|OTU.|TRAF-binding.				negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			TCCATGGACACGAGTGCAGAA	0.478000													18	96					1.50039e-11	2.07232e-11	1	1	0
PARK2	5071	broad.mit.edu	37	6	162622223	162622223	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:162622223C>A	ENST00000366898.1	-	4	576	c.474G>T	c.(472-474)caG>caT	p.Q158H	PARK2_ENST00000338468.3_Intron|PARK2_ENST00000366894.1_5'UTR|PARK2_ENST00000366896.1_Intron|PARK2_ENST00000366897.1_Missense_Mutation_p.Q158H|PARK2_ENST00000366892.1_Missense_Mutation_p.Q158H	NM_004562.2	NP_004553.2	O60260	PRKN2_HUMAN	parkin RBR E3 ubiquitin protein ligase	158					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(21)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	39		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		GTTTTCCCGGCTGCACTCTTT	0.488000													14	98					3.99206e-14	5.87749e-14	1	1	0
RP11-478B9.1	0	broad.mit.edu	37	12	45458099	45458099	+	RNA	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:45458099C>A	ENST00000548424.1	+	0	448																											CCAGCATTCCCTCTCCAATCT	0.502000													8	39					5.18039e-06	6.02221e-06	1	1	0
CNTNAP2	26047	broad.mit.edu	37	7	147675037	147675037	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:147675037C>A	ENST00000361727.3	+	15	2855	c.2339C>A	c.(2338-2340)tCa>tAa	p.S780*		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	780	Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CGTCAAGGCTCAGAAGCCAAA	0.468000										HNSCC(39;0.1)			11	42					0.00010058	0.000112925	1	1	0
SLC38A7	55238	broad.mit.edu	37	16	58705099	58705099	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:58705099C>A	ENST00000570101.1	-	9	1964	c.1081G>T	c.(1081-1083)Gag>Tag	p.E361*	SLC38A7_ENST00000564010.1_Nonsense_Mutation_p.E272*|SLC38A7_ENST00000219320.4_Nonsense_Mutation_p.E361*|SLC38A7_ENST00000566953.1_Intron|SLC38A7_ENST00000564100.1_Intron			Q9NVC3	S38A7_HUMAN	solute carrier family 38, member 7	361					amino acid transport|sodium ion transport	integral to membrane				endometrium(1)|large_intestine(2)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	13						CCCACGTCCTCCTCCACTGGC	0.682000													8	83					3.86212e-05	4.40708e-05	1	1	0
LIG4	3981	broad.mit.edu	37	13	108862241	108862241	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr13:108862241A>G	ENST00000356922.4	-	2	1648	c.1376T>C	c.(1375-1377)aTg>aCg	p.M459T	LIG4_ENST00000405925.1_Missense_Mutation_p.M459T|LIG4_ENST00000442234.1_Missense_Mutation_p.M459T	NM_002312.3|NM_206937.1	NP_002303.2|NP_996820.1	P49917	DNLI4_HUMAN	ligase IV, DNA, ATP-dependent	459					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					CAATTCATCCATTAGTCCACT	0.418000								Non-homologous end-joining					12	437					0	0	1	0	0
SLC4A4	8671	broad.mit.edu	37	4	72263332	72263332	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:72263332A>T	ENST00000340595.3	+	4	833	c.637A>T	c.(637-639)Agt>Tgt	p.S213C	SLC4A4_ENST00000512686.1_Missense_Mutation_p.S213C|SLC4A4_ENST00000351898.6_Missense_Mutation_p.S257C|SLC4A4_ENST00000514331.1_3'UTR|SLC4A4_ENST00000264485.5_Missense_Mutation_p.S257C|SLC4A4_ENST00000425175.1_Missense_Mutation_p.S257C	NM_003759.3	NP_003750.1	Q9Y6R1	S4A4_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 4	257						basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	58			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			GACTTCCTCCAGTCTGAATGA	0.378000													26	55					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2029135	2029135	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:2029135G>T	ENST00000382203.1	+	2	322	c.113G>T	c.(112-114)gGt>gTt	p.G38V	SMARCA2_ENST00000357248.2_Missense_Mutation_p.G38V|SMARCA2_ENST00000349721.2_Missense_Mutation_p.G38V|SMARCA2_ENST00000382194.1_Missense_Mutation_p.G38V			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	38					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CCATCCCCAGGTTCCGTCCAC	0.637000													8	13					0.0477658	0.0492667	1	1	0
SPATA7	55812	broad.mit.edu	37	14	88895778	88895778	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr14:88895778G>T	ENST00000556553.1	+	8	1462	c.903G>T	c.(901-903)aaG>aaT	p.K301N	SPATA7_ENST00000356583.5_Missense_Mutation_p.K301N|SPATA7_ENST00000045347.7_Missense_Mutation_p.K333N|SPATA7_ENST00000393545.4_Missense_Mutation_p.K333N			Q9P0W8	SPAT7_HUMAN	spermatogenesis associated 7	333					response to stimulus|visual perception					cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)	18						ATGAGATTAAGGATGATGCTC	0.373000													14	42					1.45105e-14	2.15916e-14	1	1	0
INO80E	283899	broad.mit.edu	37	16	30012745	30012745	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:30012745C>T	ENST00000563197.1	+	6	1424	c.407C>T	c.(406-408)tCc>tTc	p.S136F	INO80E_ENST00000567254.1_Missense_Mutation_p.S136F|INO80E_ENST00000304516.7_Intron|INO80E_ENST00000567705.1_Intron	NM_173618.1	NP_775889.1	Q8NBZ0	IN80E_HUMAN	INO80 complex subunit E	136	Pro-rich.				DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex				endometrium(1)|large_intestine(2)|lung(1)|skin(1)|urinary_tract(1)	6						ctggcctcctcccgctacccc	0.662000													5	10					0	0	1	0	0
ZNF226	7769	broad.mit.edu	37	19	44679174	44679174	+	Silent	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:44679174G>C	ENST00000300823.6	+	6	409	c.273G>C	c.(271-273)ctG>ctC	p.L91L	ZNF226_ENST00000413984.2_Silent_p.L91L|ZNF226_ENST00000590089.1_Intron|ZNF226_ENST00000588742.1_Silent_p.L91L|ZNF226_ENST00000337433.5_Intron|ZNF226_ENST00000588883.1_3'UTR|ZNF226_ENST00000454662.2_Intron	NM_001146220.2|NM_015919.3	NP_001139692.1|NP_057003.2	Q9NYT6	ZN226_HUMAN	zinc finger protein 226	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						Prostate(69;0.0352)|all_neural(266;0.202)				TCTATGACCTGGCTCAAACTT	0.343000													9	75					0	0	1	0	0
NEK7	140609	broad.mit.edu	37	1	198247150	198247150	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:198247150G>T	ENST00000367385.4	+	6	774	c.432G>T	c.(430-432)caG>caT	p.Q144H	NEK7_ENST00000538004.1_Missense_Mutation_p.Q144H	NM_133494.2	NP_598001.1	Q8TDX7	NEK7_HUMAN	NIMA-related kinase 7	144	Protein kinase.					cytoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			endometrium(3)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	21						ATTTTGTTCAGCTTTGCAGTG	0.284000													7	176					2.74318e-10	3.67955e-10	1	1	0
CTTNBP2	83992	broad.mit.edu	37	7	117432137	117432137	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:117432137G>T	ENST00000160373.3	-	4	1204	c.1113C>A	c.(1111-1113)ccC>ccA	p.P371P		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	371	Pro-rich.									breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GTGGGAAAGCGGGTACAGAAG	0.532000													19	59					1.50039e-11	2.07232e-11	1	1	0
SULF2	55959	broad.mit.edu	37	20	46307442	46307442	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:46307442C>G	ENST00000359930.4	-	8	2022	c.1171G>C	c.(1171-1173)Gac>Cac	p.D391H	SULF2_ENST00000467815.1_Missense_Mutation_p.D391H|SULF2_ENST00000484875.1_Missense_Mutation_p.D391H|CTD-2653D5.1_ENST00000526566.2_RNA|SULF2_ENST00000361612.4_Missense_Mutation_p.D391H	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	391					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						CGCTCCGTGTCCAGCAGCTTG	0.607000													20	407					0	0	1	0	0
UBBP4	23666	broad.mit.edu	37	17	21730847	21730847	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:21730847G>T	ENST00000584755.1	+	2	546	c.149G>T	c.(148-150)cGg>cTg	p.R50L	UBBP4_ENST00000578713.1_Missense_Mutation_p.R50L|UBBP4_ENST00000584398.1_Intron|UBBP4_ENST00000583708.1_Intron																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GGCAAGCAGCGGGAAGATGGC	0.522000													3	45					0.00024832	0.000273299	1	1	0
LAMC3	10319	broad.mit.edu	37	9	133901830	133901830	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:133901830T>C	ENST00000361069.4	+	2	665	c.532T>C	c.(532-534)Tac>Cac	p.Y178H	LAMC3_ENST00000480883.1_3'UTR	NM_006059.3	NP_006050.3	Q9Y6N6	LAMC3_HUMAN	laminin, gamma 3	178	Laminin N-terminal.				cell adhesion	basement membrane|membrane	structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(31)|ovary(3)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(2)|urinary_tract(3)	69	all_hematologic(7;0.0028)	Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.06e-05)|Epithelial(140;0.000551)		CGAGGGCCAGTACCTGCGCCC	0.677000													19	61					0	0	1	0	0
AGAP11	119385	broad.mit.edu	37	10	88768197	88768197	+	RNA	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:88768197C>G	ENST00000444431.1	+	0	2797				RP11-96C23.5_ENST00000433214.2_RNA|RP11-96C23.14_ENST00000444180.3_RNA			Q8TF27	AGA11_HUMAN	ankyrin repeat and GTPase domain Arf GTPase activating protein 11						regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding										ACTCCCAGCACCAGCCAGGAG	0.488000													17	161					0	0	1	0	0
TUSC5	286753	broad.mit.edu	37	17	1183628	1183628	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:1183628C>A	ENST00000333813.3	+	1	672	c.333C>A	c.(331-333)gcC>gcA	p.A111A		NM_172367.2	NP_758955.2	Q8IXB3	TUSC5_HUMAN	tumor suppressor candidate 5	111					response to biotic stimulus	integral to membrane				endometrium(2)|kidney(2)|large_intestine(3)|lung(2)|prostate(4)|skin(2)	15				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CCGTCGTCGCCTGCTTCTGCC	0.632000													4	162					0.00198382	0.0021247	1	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125192089	125192089	+	Silent	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:125192089A>T	ENST00000431078.1	+	5	922	c.558A>T	c.(556-558)cgA>cgT	p.R186R		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	186	Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TTGATGGCCGAAGCTCACTTC	0.443000													28	108					0	0	1	0	0
ZNF184	7738	broad.mit.edu	37	6	27424622	27424622	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:27424622G>A	ENST00000211936.6	-	5	565	c.281C>T	c.(280-282)cCa>cTa	p.P94L	ZNF184_ENST00000377419.1_Missense_Mutation_p.P94L	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	94	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						GGTACCTACTGGAATGCTTGG	0.438000													48	77					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196964992	196964992	+	Nonsense_Mutation	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:196964992T>A	ENST00000367414.5	+	5	881	c.825T>A	c.(823-825)tgT>tgA	p.C275*	CFHR5_ENST00000256785.4_Nonsense_Mutation_p.C251*	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	251	Sushi 5.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						AAATACAATGTGTGGATGGAG	0.303000													16	29					0	0	1	0	0
MAP3K3	4215	broad.mit.edu	37	17	61735166	61735166	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:61735166C>G	ENST00000361357.3	+	6	691	c.373C>G	c.(373-375)Ctg>Gtg	p.L125V	MAP3K3_ENST00000579585.1_Missense_Mutation_p.L125V|MAP3K3_ENST00000577395.1_Missense_Mutation_p.L94V|MAP3K3_ENST00000361733.3_Missense_Mutation_p.L94V|MAP3K3_ENST00000584573.1_Missense_Mutation_p.L125V	NM_203351.1	NP_976226.1	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	94					MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	28						CTCCATCCTGCTGAAAAACCA	0.328000													9	24					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31569684	31569684	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:31569684C>G	ENST00000379416.3	-	30	3350	c.3302G>C	c.(3301-3303)aGg>aCg	p.R1101T		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	1101					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GGGTTCCAGCCTTTTCAAGAT	0.527000													5	115					0	0	1	0	0
OR4D5	219875	broad.mit.edu	37	11	123810945	123810945	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:123810945C>A	ENST00000307033.2	+	1	696	c.622C>A	c.(622-624)Ctg>Atg	p.L208M		NM_001001965.1	NP_001001965.1	Q8NGN0	OR4D5_HUMAN	olfactory receptor, family 4, subfamily D, member 5	208					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCTGGTGACCCTGATGTGTTT	0.512000													5	227					0.248553	0.2508	1	1	0
COL5A2	1290	broad.mit.edu	37	2	189932740	189932740	+	Splice_Site	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:189932740C>A	ENST00000374866.3	-	21	1676		c.e21+1			NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2						axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			AAGGTCATTACCGGTTGGCCT	0.498000													10	35					3.07112e-06	3.60775e-06	1	1	0
CDH4	1002	broad.mit.edu	37	20	60509135	60509135	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:60509135C>A	ENST00000360469.5	+	15	2489	c.2401C>A	c.(2401-2403)Cag>Aag	p.Q801K	CDH4_ENST00000543233.1_Missense_Mutation_p.Q727K	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	801					adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			CAGCCAGCTGCAGCAGCCGGA	0.677000													30	83					1.04594e-18	1.66278e-18	1	1	0
EPHA5	2044	broad.mit.edu	37	4	66201706	66201706	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:66201706C>A	ENST00000273854.3	-	16	3396	c.2796G>T	c.(2794-2796)ttG>ttT	p.L932F	EPHA5_ENST00000511294.1_Missense_Mutation_p.L933F|EPHA5_ENST00000432638.2_Missense_Mutation_p.L769F|EPHA5_ENST00000354839.4_Missense_Mutation_p.L910F	NM_004439.5	NP_004430.4	P54756	EPHA5_HUMAN	EPH receptor A5	932	Protein kinase.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(25)|liver(1)|lung(76)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	142						TCAGCTTGTCCAACATGTTGA	0.468000										TSP Lung(17;0.13)			23	91					3.73148e-12	5.28468e-12	1	1	0
PLEC	5339	broad.mit.edu	37	8	144995483	144995483	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:144995483C>T	ENST00000322810.4	-	32	9086	c.8917G>A	c.(8917-8919)Gac>Aac	p.D2973N	PLEC_ENST00000345136.3_Missense_Mutation_p.D2836N|PLEC_ENST00000527096.1_Missense_Mutation_p.D2859N|PLEC_ENST00000398774.2_Missense_Mutation_p.D2804N|PLEC_ENST00000354958.2_Missense_Mutation_p.D2814N|PLEC_ENST00000436759.2_Missense_Mutation_p.D2863N|PLEC_ENST00000357649.2_Missense_Mutation_p.D2840N|PLEC_ENST00000354589.3_Missense_Mutation_p.D2836N|PLEC_ENST00000356346.3_Missense_Mutation_p.D2822N	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	2973	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle	p.D2973N(1)|p.D2836N(1)|p.D2863N(1)		NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						ATCTCCTCGTCGAAGTAGCCG	0.667000													20	196					0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109697789	109697789	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:109697789A>T	ENST00000465301.2	+	3	4190	c.3944A>T	c.(3943-3945)aAg>aTg	p.K1315M	RGAG1_ENST00000540313.1_Missense_Mutation_p.K1315M	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	1315										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						GCTGAAGAGAAGGATTCCCCA	0.542000													31	24					0	0	1	0	0
TMTC3	160418	broad.mit.edu	37	12	88584315	88584315	+	Missense_Mutation	SNP	A	A	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:88584315A>C	ENST00000266712.6	+	12	1842	c.1622A>C	c.(1621-1623)aAt>aCt	p.N541T		NM_181783.3	NP_861448.2	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat containing 3	541						integral to membrane	binding			NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|liver(1)|lung(12)|prostate(4)|skin(1)	31						ATCCGAGCAAATGAGTCCCGA	0.433000													40	88					0	0	1	0	0
CHORDC1	26973	broad.mit.edu	37	11	89936515	89936515	+	Silent	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:89936515T>A	ENST00000529726.1	-	2	4099	c.186A>T	c.(184-186)tcA>tcT	p.S62S	CHORDC1_ENST00000320585.6_Silent_p.S250S|CHORDC1_ENST00000457199.2_Silent_p.S231S|CHORDC1_ENST00000529987.1_Silent_p.S62S			Q9UHD1	CHRD1_HUMAN	cysteine and histidine-rich domain (CHORD) containing 1	250	CHORD 1.|Interaction with PPP5C (By similarity).				chaperone-mediated protein folding|regulation of response to stress|response to stress		Hsp90 protein binding|identical protein binding			endometrium(2)|large_intestine(2)|liver(1)|lung(6)	11		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.00915)				GTTCTGGAAGTGAGTTTTTAG	0.353000													17	94					0	0	1	0	0
TXNRD2	10587	broad.mit.edu	37	22	19883051	19883051	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr22:19883051C>A	ENST00000535882.1	-	11	824	c.825G>T	c.(823-825)ctG>ctT	p.L275L	TXNRD2_ENST00000400521.1_Silent_p.L276L|TXNRD2_ENST00000400519.1_Silent_p.L275L|TXNRD2_ENST00000542719.1_Silent_p.L246L|TXNRD2_ENST00000400525.1_Silent_p.L253L|TXNRD2_ENST00000400518.1_Silent_p.L246L|TXNRD2_ENST00000491939.1_5'UTR|TXNRD2_ENST00000334363.9_Silent_p.L276L			Q9NNW7	TRXR2_HUMAN	thioredoxin reductase 2	276					cell redox homeostasis|response to oxygen radical	mitochondrion	flavin adenine dinucleotide binding|NADP binding|thioredoxin-disulfide reductase activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|urinary_tract(2)	30	Colorectal(54;0.0993)					CACAGCCCCTCAGGAACCGGG	0.622000													21	60					7.87624e-14	1.14452e-13	1	1	0
NPAS4	266743	broad.mit.edu	37	11	66191995	66191995	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:66191995C>A	ENST00000311034.2	+	7	1810	c.1634C>A	c.(1633-1635)cCc>cAc	p.P545H		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	545					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						CTGGACAGCCCCAGCCAAACC	0.582000													118	225					1.74079e-70	3.09351e-70	1	1	0
SLIT1	6585	broad.mit.edu	37	10	98764458	98764458	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:98764458G>T	ENST00000266058.4	-	33	3947	c.3702C>A	c.(3700-3702)gcC>gcA	p.A1234A	SLIT1_ENST00000371070.4_Silent_p.A1234A|ARHGAP19-SLIT1_ENST00000453547.2_3'UTR	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	1234	Laminin G-like.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		ACCTGTAGATGGCAGAGCTGG	0.607000													15	64					1.99824e-07	2.43986e-07	1	1	0
HMSD	284293	broad.mit.edu	37	18	61620716	61620716	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr18:61620716G>T	ENST00000408945.3	+	2	229	c.27G>T	c.(25-27)atG>atT	p.M9I	HMSD_ENST00000481726.1_Intron	NM_001123366.1	NP_001116838.1	A8MTL9	HMSD_HUMAN	histocompatibility (minor) serpin domain containing	9						extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(2)|lung(2)|stomach(1)	6						CCTTGGCCATGGTTTTCATGG	0.408000													6	38					1	1	1	1	0
UNC5C	8633	broad.mit.edu	37	4	96166241	96166241	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:96166241C>A	ENST00000453304.1	-	6	1178	c.830G>T	c.(829-831)gGa>gTa	p.G277V	UNC5C_ENST00000506749.1_Missense_Mutation_p.G277V	NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	277	TSP type-1 1.				apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		ATACCCTCGTCCACAGCGGCT	0.517000													11	52					1.08611e-07	1.34977e-07	1	1	0
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48873625	48873625	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:48873625T>C	ENST00000394754.1	+	8	2648	c.2534T>C	c.(2533-2535)gTg>gCg	p.V845A	GTF2A1L_ENST00000468326.1_3'UTR|GTF2A1L_ENST00000403751.3_Missense_Mutation_p.V141A|LHCGR_ENST00000420913.3_5'UTR|GTF2A1L_ENST00000430487.2_Missense_Mutation_p.V107A|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.V798A|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.V845A|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.V845A|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.V845A	NM_172311.2	NP_758515.1	B7ZL16	B7ZL16_HUMAN		798					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(22)|liver(2)|lung(49)|ovary(3)|pancreas(1)|prostate(4)|skin(4)	91		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CCAATTATGGTGACAGAGACT	0.358000													13	87					0	0	1	0	0
DSG3	1830	broad.mit.edu	37	18	29055649	29055649	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr18:29055649C>A	ENST00000257189.4	+	16	2509	c.2426C>A	c.(2425-2427)gCa>gAa	p.A809E		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	809					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GGCCAGGAAGCAAATGACTGC	0.433000													19	92					5.60225e-13	7.99503e-13	1	1	0
MOGAT2	80168	broad.mit.edu	37	11	75438611	75438611	+	Silent	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:75438611T>A	ENST00000526712.1	+	2	929	c.156T>A	c.(154-156)ggT>ggA	p.G52G	MOGAT2_ENST00000198801.5_Silent_p.G134G			Q3SYC2	MOGT2_HUMAN	monoacylglycerol O-acyltransferase 2	134					glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			NS(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	20	Ovarian(111;0.103)					TCTTCCCCGGTATCCGCCCCC	0.572000													56	162					0	0	1	0	0
STK11	6794	broad.mit.edu	37	19	1219355	1219355	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:1219355T>A	ENST00000326873.7	+	3	1580	c.407T>A	c.(406-408)aTg>aAg	p.M136K	STK11_ENST00000585748.1_3'UTR	NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	136	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.?(2)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGTGTGGCATGCAGGAAATG	0.701000		14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			5	6					0	0	1	0	0
UBR1	197131	broad.mit.edu	37	15	43378282	43378282	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr15:43378282C>T	ENST00000290650.4	-	2	316	c.238G>A	c.(238-240)Gga>Aga	p.G80R	UBR1_ENST00000382177.2_Missense_Mutation_p.G80R	NM_174916.2	NP_777576.1	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin 1	80					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			NS(2)|endometrium(2)|kidney(7)|large_intestine(12)|lung(25)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	58		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		GGATCTTCTCCAAATAAGTAC	0.413000													39	92					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176738910	176738910	+	Silent	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:176738910C>T	ENST00000367662.3	+	16	5655	c.4491C>T	c.(4489-4491)gcC>gcT	p.A1497A		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1497	Sushi 2.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TCCCACCAGCCAAGCTGCAAG	0.507000													25	130					0	0	1	0	0
CPNE4	131034	broad.mit.edu	37	3	131624135	131624135	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:131624135C>A	ENST00000512055.1	-	6	2279	c.153G>T	c.(151-153)aaG>aaT	p.K51N	CPNE4_ENST00000512332.1_Missense_Mutation_p.K69N|CPNE4_ENST00000429747.1_Missense_Mutation_p.K51N|CPNE4_ENST00000511604.1_Missense_Mutation_p.K51N|CPNE4_ENST00000502818.1_Missense_Mutation_p.K69N			Q96A23	CPNE4_HUMAN	copine IV	51	C2 1.									central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|liver(1)|lung(16)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	39						GAGACTGCATCTTGAGGATGA	0.473000													36	162					4.14194e-30	7.13333e-30	1	1	0
ASB5	140458	broad.mit.edu	37	4	177146444	177146444	+	Missense_Mutation	SNP	C	C	A	rs139180399	byFrequency	TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:177146444C>A	ENST00000296525.3	-	2	358	c.245G>T	c.(244-246)cGc>cTc	p.R82L	ASB5_ENST00000511879.1_5'UTR|ASB5_ENST00000512254.1_Missense_Mutation_p.R29L	NM_080874.3	NP_543150.1	Q8WWX0	ASB5_HUMAN	ankyrin repeat and SOCS box containing 5	82					intracellular signal transduction					endometrium(2)|kidney(1)|large_intestine(9)|lung(18)|prostate(2)|skin(2)	34		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.13e-20)|Epithelial(43;9.94e-18)|OV - Ovarian serous cystadenocarcinoma(60;2e-09)|GBM - Glioblastoma multiforme(59;0.000254)|STAD - Stomach adenocarcinoma(60;0.000653)|LUSC - Lung squamous cell carcinoma(193;0.0393)		AGCAAGAAGGCGACCTTGACT	0.363000													12	67					1.5739e-10	2.12134e-10	1	1	0
SORCS2	57537	broad.mit.edu	37	4	7725523	7725523	+	Missense_Mutation	SNP	T	T	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr4:7725523T>G	ENST00000507866.2	+	19	2633	c.2524T>G	c.(2524-2526)Tac>Gac	p.Y842D	SORCS2_ENST00000329016.9_Missense_Mutation_p.Y670D	NM_020777.2	NP_065828.2	Q96PQ0	SORC2_HUMAN	sortilin-related VPS10 domain containing receptor 2	842	PKD.					integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(8)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	42						CCGGCACCGCTACGAGAGCCC	0.592000													49	115					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34148765	34148765	+	Missense_Mutation	SNP	C	C	A	rs45577239		TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:34148765C>A	ENST00000346193.3	-	1	1682	c.1631G>T	c.(1630-1632)cGc>cTc	p.R544L		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	544										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						AAGCTCCGGGCGGAGACTGGA	0.632000													3	48					0.115264	0.11823	1	1	0
SORT1	6272	broad.mit.edu	37	1	109897034	109897034	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:109897034C>T	ENST00000256637.6	-	5	721	c.663G>A	c.(661-663)atG>atA	p.M221I	SORT1_ENST00000538502.1_Missense_Mutation_p.M85I	NM_002959.5	NP_002950.3	Q99523	SORT_HUMAN	sortilin 1	221					endocytosis|endosome to lysosome transport|endosome transport via multivesicular body sorting pathway|glucose import|Golgi to endosome transport|induction of apoptosis by extracellular signals|myotube differentiation|negative regulation of apoptosis|negative regulation of lipoprotein lipase activity|neuropeptide signaling pathway|ossification|plasma membrane to endosome transport|regulation of gene expression|response to insulin stimulus|vesicle organization	cell surface|coated pit|early endosome|endoplasmic reticulum membrane|endosome membrane|Golgi cisterna membrane|integral to membrane|lysosomal membrane|microsome|nuclear membrane|perinuclear region of cytoplasm|plasma membrane	enzyme binding|nerve growth factor binding|nerve growth factor receptor activity|neurotensin receptor activity, non-G-protein coupled			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(5)|ovary(2)|prostate(1)|skin(1)	26		all_epithelial(167;4.69e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0529)|Colorectal(144;0.142)|Epithelial(280;0.145)|Kidney(133;0.169)|all cancers(265;0.184)		GAGGGCTATACATCATCTGAG	0.393000													17	86					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135428781	135428781	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:135428781G>T	ENST00000394143.1	+	6	3207	c.2916G>T	c.(2914-2916)agG>agT	p.R972S	GPR112_ENST00000287534.4_Missense_Mutation_p.R909S|GPR112_ENST00000412101.1_Missense_Mutation_p.R767S|GPR112_ENST00000394141.1_Missense_Mutation_p.R767S|GPR112_ENST00000370652.1_Missense_Mutation_p.R972S	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	972					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CTACCACAAGGATATCAGAAA	0.498000													41	67					6.03219e-31	1.04209e-30	1	1	0
GMDS	2762	broad.mit.edu	37	6	1960206	1960206	+	Splice_Site	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:1960206C>A	ENST00000380815.4	-	6	808		c.e6-1		GMDS_ENST00000530927.1_Splice_Site	NM_001500.3	NP_001491.1	O60547	GMDS_HUMAN	GDP-mannose 4,6-dehydratase						'de novo' GDP-L-fucose biosynthetic process|GDP-mannose metabolic process|leukocyte cell-cell adhesion		coenzyme binding|GDP-mannose 4,6-dehydratase activity		GMDS/PDE8B(2)	breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|prostate(1)	21	Ovarian(93;0.0733)	all_cancers(2;7.64e-19)|all_epithelial(2;3.05e-16)|Colorectal(2;0.00414)|all_hematologic(90;0.00997)|all_lung(73;0.0141)|Lung NSC(90;0.0802)		Epithelial(2;7.61e-06)|all cancers(2;0.000111)|STAD - Stomach adenocarcinoma(2;0.000231)|Colorectal(2;0.00445)|COAD - Colon adenocarcinoma(2;0.0125)|OV - Ovarian serous cystadenocarcinoma(45;0.0563)		TTTGCTGCCCCTGTTGGAATA	0.388000													12	35					6.40141e-05	7.24541e-05	1	1	0
ZNF185	7739	broad.mit.edu	37	X	152086639	152086639	+	Silent	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chrX:152086639T>A	ENST00000535861.1	+	6	420	c.372T>A	c.(370-372)gcT>gcA	p.A124A	ZNF185_ENST00000370268.4_Silent_p.A124A|ZNF185_ENST00000318504.7_Silent_p.A124A|ZNF185_ENST00000318529.8_5'UTR|ZNF185_ENST00000324823.6_5'UTR|ZNF185_ENST00000449285.2_Silent_p.A124A|ZNF185_ENST00000539731.1_Silent_p.A124A	NM_001178106.1	NP_001171577.1	O15231	ZN185_HUMAN	zinc finger protein 185 (LIM domain)	124						cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(3)	12	Acute lymphoblastic leukemia(192;6.56e-05)					CAGCTAACGCTGGTCCTCCCC	0.582000													5	6					0	0	1	0	0
OR2T11	127077	broad.mit.edu	37	1	248790325	248790325	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:248790325G>T	ENST00000330803.2	-	1	166	c.105C>A	c.(103-105)gcC>gcA	p.A35A		NM_001001964.1	NP_001001964.1	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T, member 11 (gene/pseudogene)	35					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.A35A(1)		breast(1)|large_intestine(5)|lung(20)|skin(2)	28	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGCAGTCACGGCCCCCAAGA	0.517000													29	54					2.70662e-09	3.5205e-09	1	1	0
BACE1	23621	broad.mit.edu	37	11	117165932	117165932	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:117165932G>A	ENST00000313005.6	-	3	942	c.482C>T	c.(481-483)gCt>gTt	p.A161V	BACE1_ENST00000428381.2_Intron|BACE1_ENST00000510630.1_Missense_Mutation_p.A61V|BACE1_ENST00000528053.1_Missense_Mutation_p.A161V|BACE1_ENST00000514464.1_Intron|BACE1_ENST00000513780.1_Missense_Mutation_p.A161V|BACE1_ENST00000445823.2_Intron|BACE1_ENST00000392937.6_Missense_Mutation_p.A61V	NM_012104.4|NM_138971.3|NM_138972.3|NM_138973.3	NP_036236.1|NP_620427.1|NP_620428.1|NP_620429.1	P56817	BACE1_HUMAN	beta-site APP-cleaving enzyme 1	161					beta-amyloid metabolic process|membrane protein ectodomain proteolysis	cell surface|cytoplasmic vesicle membrane|endoplasmic reticulum|endosome|integral to plasma membrane|trans-Golgi network	aspartic-type endopeptidase activity|beta-aspartyl-peptidase activity|protein binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000563)|all cancers(92;0.0032)		AGTGATGGCAGCAATGTTGGC	0.587000													4	157					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7789838	7789838	+	Silent	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:7789838G>C	ENST00000338316.4	+	20	2642	c.2553G>C	c.(2551-2553)ctG>ctC	p.L851L	ADCY2_ENST00000537121.1_Silent_p.L671L	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	851					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						TGGAGAACCTGAACCGCGTGC	0.527000													10	61					0	0	1	0	0
TPX2	22974	broad.mit.edu	37	20	30347911	30347911	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:30347911G>T	ENST00000340513.4	+	4	686	c.158G>T	c.(157-159)gGg>gTg	p.G53V	TPX2_ENST00000300403.6_Missense_Mutation_p.G53V			Q9ULW0	TPX2_HUMAN	TPX2, microtubule-associated	53					activation of protein kinase activity|apoptosis|cell division|cell proliferation|mitosis|regulation of mitotic spindle organization	cytoplasm|microtubule|nucleus|spindle pole	ATP binding|GTP binding|protein kinase binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28			Epithelial(4;0.000771)|Colorectal(19;0.00306)|all cancers(5;0.004)|COAD - Colon adenocarcinoma(19;0.0347)|OV - Ovarian serous cystadenocarcinoma(3;0.0656)			GGAACTGGAGGGCTTTTTCAG	0.413000													16	72					3.45872e-05	3.97112e-05	1	1	0
NOBOX	135935	broad.mit.edu	37	7	144097306	144097306	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:144097306C>A	ENST00000467773.1	-	5	943	c.944G>T	c.(943-945)cGc>cTc	p.R315L	NOBOX_ENST00000483238.1_Missense_Mutation_p.R315L|NOBOX_ENST00000223140.5_Missense_Mutation_p.R230L	NM_001080413.3	NP_001073882.3	O60393	NOBOX_HUMAN	NOBOX oogenesis homeobox	315					cell differentiation|oogenesis	nucleus	sequence-specific DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	26	Melanoma(164;0.14)					TACCATGATGCGCTGGGGGGT	0.587000													24	62					6.38683e-12	8.99963e-12	1	1	0
VRTN	55237	broad.mit.edu	37	14	74824136	74824136	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr14:74824136C>A	ENST00000256362.4	+	2	891	c.650C>A	c.(649-651)aCg>aAg	p.T217K		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	217					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						GTGCCCTCCACGCTGCACATC	0.632000													27	66					2.47316e-13	3.54761e-13	1	1	0
GCSAML	148823	broad.mit.edu	37	1	247737464	247737464	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:247737464G>C	ENST00000366491.2	+	7	625	c.128G>C	c.(127-129)gGt>gCt	p.G43A	GCSAML_ENST00000463359.1_Missense_Mutation_p.G31A|GCSAML_ENST00000366489.1_Missense_Mutation_p.G43A|RP11-978I15.10_ENST00000446347.1_RNA|GCSAML_ENST00000527541.1_Missense_Mutation_p.G31A|GCSAML_ENST00000536561.1_Missense_Mutation_p.G43A|RP11-978I15.10_ENST00000435333.1_RNA|GCSAML_ENST00000527084.1_Missense_Mutation_p.G31A|GCSAML_ENST00000366488.4_Missense_Mutation_p.G63A					germinal center-associated, signaling and motility-like																		AATGGCAGTGGTTCTGAAGAA	0.443000													42	144					0	0	1	0	0
SERPINB13	5275	broad.mit.edu	37	18	61261683	61261683	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr18:61261683G>A	ENST00000344731.5	+	6	669	c.567G>A	c.(565-567)agG>agA	p.R189R	SERPINB13_ENST00000269489.5_Silent_p.R189R	NM_012397.3	NP_036529.1	Q9UIV8	SPB13_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 13	189					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						AATGGGACAGGGAGTTTAAGA	0.383000													12	41					0	0	1	0	0
PTCD1	26024	broad.mit.edu	37	7	99032694	99032694	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:99032694C>A	ENST00000292478.4	-	2	422	c.172G>T	c.(172-174)Gag>Tag	p.E58*	ATP5J2-PTCD1_ENST00000413834.1_Nonsense_Mutation_p.E107*|PTCD1_ENST00000555673.1_Nonsense_Mutation_p.E107*	NM_015545.3	NP_056360.2			pentatricopeptide repeat domain 1											endometrium(5)|large_intestine(3)|lung(16)|ovary(2)|skin(1)	27	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			TCCTGACGCTCCTGGCCGAGG	0.662000													6	9					3.09899e-07	3.74293e-07	1	1	0
MYO3B	140469	broad.mit.edu	37	2	171238572	171238572	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:171238572G>T	ENST00000334231.6	+	10	1045	c.1045G>T	c.(1045-1047)Gaa>Taa	p.E349*	MYO3B_ENST00000408978.4_Nonsense_Mutation_p.E340*|MYO3B_ENST00000602629.1_3'UTR|MYO3B_ENST00000409044.3_Nonsense_Mutation_p.E340*			Q8WXR4	MYO3B_HUMAN	myosin IIIB	340	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						GGAAGATGCTGAAAAATACTG	0.363000													18	59					6.44725e-10	8.54529e-10	1	1	0
PCDH15	65217	broad.mit.edu	37	10	55569225	55569225	+	Nonsense_Mutation	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:55569225T>A	ENST00000395445.1	-	36	4979	c.4585A>T	c.(4585-4587)Aaa>Taa	p.K1529*	PCDH15_ENST00000395438.1_3'UTR|PCDH15_ENST00000395446.1_Nonsense_Mutation_p.K725*|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000409834.1_3'UTR|PCDH15_ENST00000395440.1_Nonsense_Mutation_p.K463*|PCDH15_ENST00000395442.1_Nonsense_Mutation_p.K394*	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GCTGGTGGTTTTTCGATAGTT	0.373000										HNSCC(58;0.16)			47	121					0	0	1	0	0
CD84	8832	broad.mit.edu	37	1	160523822	160523822	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:160523822C>A	ENST00000368054.3	-	3	538	c.503G>T	c.(502-504)tGg>tTg	p.W168L	CD84_ENST00000534968.1_Missense_Mutation_p.W54L|CD84_ENST00000311224.4_Missense_Mutation_p.W168L|RP11-528G1.2_ENST00000446952.1_RNA|CD84_ENST00000368047.3_5'UTR|CD84_ENST00000368048.3_Missense_Mutation_p.W168L|CD84_ENST00000368051.3_Missense_Mutation_p.W168L	NM_003874.3	NP_003865.1	Q9UIB8	SLAF5_HUMAN	CD84 molecule	168	Ig-like C2-type.				blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(1)	24	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CAGGGGACTCCAATTGTATGT	0.453000													9	83					0.00621372	0.00655435	1	1	0
MMP16	4325	broad.mit.edu	37	8	89086933	89086933	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:89086933C>A	ENST00000286614.6	-	7	1403	c.1122G>T	c.(1120-1122)atG>atT	p.M374I	MMP16_ENST00000544227.1_5'UTR	NM_005941.4	NP_005932.2	P51512	MMP16_HUMAN	matrix metallopeptidase 16 (membrane-inserted)	374	Hemopexin-like 1.				collagen catabolic process|proteolysis	cell surface|integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(1)|lung(51)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	81						GGTATCCATCCATCACCCTGT	0.478000													21	190					1.66031e-10	2.23241e-10	1	1	0
PCDHB12	56124	broad.mit.edu	37	5	140590803	140590803	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:140590803T>A	ENST00000239450.2	+	1	2513	c.2324T>A	c.(2323-2325)cTa>cAa	p.L775Q	PCDHB12_ENST00000541609.1_Missense_Mutation_p.L438Q	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		775					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCAACTTCCTACCCCAGAGC	0.423000													27	89					0	0	1	0	0
MKRN3	7681	broad.mit.edu	37	15	23811323	23811323	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr15:23811323G>T	ENST00000314520.3	+	1	870	c.394G>T	c.(394-396)Gtt>Ttt	p.V132F	MKRN3_ENST00000564592.1_Intron|MKRN3_ENST00000568252.1_Intron	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	132						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		TGAGGGTGGCGTTTCGCCGCC	0.627000													20	54					4.87955e-14	7.12773e-14	1	1	0
KRTAP27-1	643812	broad.mit.edu	37	21	31709534	31709534	+	Silent	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr21:31709534G>A	ENST00000382835.2	-	1	478	c.453C>T	c.(451-453)ttC>ttT	p.F151F		NM_001077711.1	NP_001071179.1	Q3LI81	KR271_HUMAN	keratin associated protein 27-1	151						intermediate filament		p.F151F(2)		endometrium(2)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|skin(1)	18						CCAGAGTTTCGAAATTTTTAG	0.493000													50	119					0	0	1	0	0
PCNT	5116	broad.mit.edu	37	21	47754527	47754527	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr21:47754527A>G	ENST00000359568.5	+	3	591	c.484A>G	c.(484-486)Agt>Ggt	p.S162G	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	162					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GTTCACAGTCAGTGACCACCC	0.552000													4	133					0	0	1	0	0
ATP5F1	515	broad.mit.edu	37	1	111996840	111996840	+	Nonsense_Mutation	SNP	C	C	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:111996840C>T	ENST00000369722.3	+	3	691	c.85C>T	c.(85-87)Cag>Tag	p.Q29*	ATP5F1_ENST00000369721.4_Intron|ATP5F1_ENST00000483994.1_Intron	NM_001688.4	NP_001679.2	P24539	AT5F1_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1	29					ATP catabolic process|respiratory electron transport chain	mitochondrial matrix|mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	hydrogen ion transporting ATP synthase activity, rotational mechanism|protein binding			breast(1)|cervix(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)	8		all_cancers(81;8.16e-06)|all_epithelial(167;5.63e-06)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|Colorectal(144;0.0296)|all cancers(265;0.0488)|Epithelial(280;0.0732)|COAD - Colon adenocarcinoma(174;0.114)|LUSC - Lung squamous cell carcinoma(189;0.135)		TAGGGTATTGCAGGCAACAAG	0.418000													14	49					0	0	1	0	0
HAND1	9421	broad.mit.edu	37	5	153857485	153857485	+	Silent	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:153857485G>C	ENST00000231121.2	-	1	339	c.84C>G	c.(82-84)ctC>ctG	p.L28L		NM_004821.2	NP_004812.1	O96004	HAND1_HUMAN	heart and neural crest derivatives expressed 1	28					angiogenesis|cardiac left ventricle formation|cardiac right ventricle formation|cardiac septum morphogenesis|heart looping|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|trophectodermal cell differentiation|ventricular cardiac muscle tissue morphogenesis	cytoplasm|nucleolus|nucleoplasm	bHLH transcription factor binding|DNA binding|protein homodimerization activity|transcription coactivator activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)	6	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			CCGGACCGAAGAGGAAGGGTT	0.672000													10	154					0	0	1	0	0
CDCA2	157313	broad.mit.edu	37	8	25365090	25365090	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:25365090G>C	ENST00000330560.3	+	15	3385	c.2908G>C	c.(2908-2910)Gaa>Caa	p.E970Q	CDCA2_ENST00000521098.2_3'UTR|CDCA2_ENST00000380665.3_Missense_Mutation_p.E955Q	NM_152562.2	NP_689775.2	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	970					cell division|mitosis	cytoplasm|nucleus				breast(3)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(7)|lung(10)|ovary(1)|prostate(3)	35		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		TTCTTCCGATGAACCTGGTAA	0.483000													9	236					0	0	1	0	0
TLR4	7099	broad.mit.edu	37	9	120470855	120470855	+	Silent	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:120470855T>A	ENST00000355622.6	+	2	209	c.108T>A	c.(106-108)atT>atA	p.I36I	TLR4_ENST00000472304.1_Intron|TLR4_ENST00000394487.4_5'UTR	NM_138554.4|NM_138557.2	NP_612564.1|NP_612567.1	O00206	TLR4_HUMAN	toll-like receptor 4	36					activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(12)|lung(66)|ovary(4)|pancreas(1)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	103						TTCCTAATATTACTTATCAAT	0.468000													39	116					0	0	1	0	0
TRIM56	81844	broad.mit.edu	37	7	100730990	100730990	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:100730990G>T	ENST00000306085.6	+	3	694	c.397G>T	c.(397-399)Gac>Tac	p.D133Y		NM_030961.1	NP_112223.1	Q9BRZ2	TRI56_HUMAN	tripartite motif containing 56	133					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	Lung NSC(181;0.136)|all_lung(186;0.182)					GGCCTGTGCCGACGGGCACCG	0.726000													8	25					1.58986e-06	1.88353e-06	1	1	0
ASIC4	55515	broad.mit.edu	37	2	220396544	220396544	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:220396544G>T	ENST00000358078.4	+	2	1042	c.1028G>T	c.(1027-1029)cGg>cTg	p.R343L	ASIC4_ENST00000347842.3_Missense_Mutation_p.R343L|ASIC4_ENST00000473709.1_3'UTR			Q96FT7	ACCN4_HUMAN	acid-sensing (proton-gated) ion channel family member 4	343						integral to plasma membrane	sodium channel activity|sodium ion transmembrane transporter activity										CTGCCCAGCCGGGCAGGGGGC	0.627000													27	107					2.85442e-18	4.51208e-18	1	1	0
ACP1	52	broad.mit.edu	37	2	272088	272088	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:272088G>T	ENST00000272065.5	+	3	262	c.169G>T	c.(169-171)Gac>Tac	p.D57Y	ACP1_ENST00000407983.3_Missense_Mutation_p.D57Y|ACP1_ENST00000439645.2_Intron|ACP1_ENST00000405233.1_Intron|ACP1_ENST00000484464.1_3'UTR|ACP1_ENST00000272067.6_Intron	NM_004300.3	NP_004291.1	P24666	PPAC_HUMAN	acid phosphatase 1, soluble	57						cytoplasm|internal side of plasma membrane|nucleus|soluble fraction	acid phosphatase activity|identical protein binding|non-membrane spanning protein tyrosine phosphatase activity			endometrium(1)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	12	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00175)|Lung NSC(108;0.216)|all_epithelial(98;0.236)		all cancers(51;0.000391)|Epithelial(75;0.00281)|OV - Ovarian serous cystadenocarcinoma(76;0.00542)|GBM - Glioblastoma multiforme(21;0.127)		GAACCCCCCTGACTACCGAGG	0.512000													30	89					5.44703e-19	8.73403e-19	1	1	0
GTF3C3	9330	broad.mit.edu	37	2	197636477	197636477	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:197636477G>A	ENST00000263956.3	-	15	2344	c.2255C>T	c.(2254-2256)gCg>gTg	p.A752V		NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	752						transcription factor TFIIIC complex	DNA binding|protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						CTTACCAAGCGCATGCTTAAA	0.438000													15	39					0	0	1	0	0
GUCY2C	2984	broad.mit.edu	37	12	14849271	14849271	+	Missense_Mutation	SNP	T	T	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:14849271T>G	ENST00000261170.3	-	1	248	c.112A>C	c.(112-114)Agc>Cgc	p.S38R	RP11-174G6.1_ENST00000501178.2_RNA	NM_004963.3	NP_004954.2	P25092	GUC2C_HUMAN	guanylate cyclase 2C (heat stable enterotoxin receptor)	38					intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			breast(3)|endometrium(7)|kidney(3)|large_intestine(9)|lung(17)|ovary(4)|skin(7)|urinary_tract(1)	51						ATCAGGACGCTGATTTCATAG	0.527000													6	38					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220312959	220312959	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:220312959C>A	ENST00000312358.7	+	4	1211	c.1079C>A	c.(1078-1080)tCg>tAg	p.S360*	SPEG_ENST00000396695.2_5'UTR|SPEG_ENST00000396698.1_Nonsense_Mutation_p.S256*|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	360					muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		AAGTCCAAGTCGTCCGGGCCC	0.716000													6	32					5.18039e-06	6.02221e-06	1	1	0
ZNF676	163223	broad.mit.edu	37	19	22375858	22375858	+	Silent	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:22375858G>T	ENST00000397121.2	-	2	407	c.90C>A	c.(88-90)ccC>ccA	p.P30P		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	30	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TCATATTCCAGGGCTCTTTTC	0.423000													10	125					0.000151284	0.000168161	1	1	0
FAM135B	51059	broad.mit.edu	37	8	139164776	139164776	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:139164776G>T	ENST00000395297.1	-	13	2112	c.1942C>A	c.(1942-1944)Ctg>Atg	p.L648M		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	648								p.L648M(4)		NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GGCTCCCTCAGGGTAGAACTT	0.483000										HNSCC(54;0.14)			13	79					0.000566183	0.000618259	1	1	0
GUCY1A2	2977	broad.mit.edu	37	11	106647301	106647301	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:106647301G>T	ENST00000526355.1	-	6	2168	c.1700C>A	c.(1699-1701)aCa>aAa	p.T567K	GUCY1A2_ENST00000347596.2_Missense_Mutation_p.T588K|GUCY1A2_ENST00000282249.2_Missense_Mutation_p.T567K	NM_000855.2	NP_000846.1	P33402	GCYA2_HUMAN	guanylate cyclase 1, soluble, alpha 2	567	Guanylate cyclase.				intracellular signal transduction|platelet activation	cytoplasm	GTP binding|guanylate cyclase activity|heme binding			breast(5)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(18)|liver(1)|lung(32)|ovary(1)|pancreas(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	74		all_epithelial(67;3.66e-05)|Melanoma(852;0.000382)|Acute lymphoblastic leukemia(157;0.001)|all_hematologic(158;0.0017)|Breast(348;0.026)|all_neural(303;0.068)		BRCA - Breast invasive adenocarcinoma(274;8.04e-05)|Epithelial(105;0.0036)|all cancers(92;0.0476)		ATCACCTATTGTTTCCACCTG	0.423000													16	51					3.62473e-10	4.85036e-10	1	1	0
OR4D6	219983	broad.mit.edu	37	11	59224661	59224661	+	Silent	SNP	C	C	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:59224661C>A	ENST00000300127.2	+	1	251	c.228C>A	c.(226-228)atC>atA	p.I76I		NM_001004708.1	NP_001004708.1	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D, member 6	76					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	34						TTTCATCTATCACCGTCCCCA	0.468000													17	40					5.35267e-07	6.43704e-07	1	1	0
ANKEF1	63926	broad.mit.edu	37	20	10030076	10030076	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr20:10030076C>G	ENST00000378380.3	+	6	1188	c.859C>G	c.(859-861)Ccc>Gcc	p.P287A	SNAP25-AS1_ENST00000603542.1_RNA|ANKEF1_ENST00000488991.1_3'UTR|SNAP25-AS1_ENST00000421143.2_RNA|ANKEF1_ENST00000378392.1_Missense_Mutation_p.P287A	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		TCATAAAACGCCCAGGGCTGT	0.438000													35	117					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179510709	179510709	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:179510709G>C	ENST00000589042.1	-	217	40570	c.40346C>G	c.(40345-40347)cCc>cGc	p.P13449R	TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.P10881R|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.P11808R|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11808	Ig-like 90.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGGAGGTGGGGGTCTTGGTTT	0.393000													6	17					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11757540	11757540	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:11757540C>G	ENST00000262442.3	+	50	9796	c.9728C>G	c.(9727-9729)cCg>cGg	p.P3243R	DNAH9_ENST00000454412.2_Missense_Mutation_p.P3243R	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	3243	Stalk (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GCCATCAGGCCGTATCTGCAA	0.493000													34	115					0	0	1	0	0
TMEM106A	113277	broad.mit.edu	37	17	41369735	41369735	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:41369735A>T	ENST00000331615.3	+	9	941	c.704A>T	c.(703-705)gAg>gTg	p.E235V	LINC00854_ENST00000427995.1_RNA|TMEM106A_ENST00000588659.1_Missense_Mutation_p.E235V|TMEM106A_ENST00000541594.1_Missense_Mutation_p.E187V|TMEM106A_ENST00000536052.1_Missense_Mutation_p.E188V	NM_145041.1	NP_659478.1	Q96A25	T106A_HUMAN	transmembrane protein 106A	235						integral to membrane				NS(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)	11		Breast(137;0.0164)		BRCA - Breast invasive adenocarcinoma(366;0.0917)		AGCCATTCAGAGCAGCTGGTC	0.567000													99	237					0	0	1	0	0
ATP11A	23250	broad.mit.edu	37	13	113477682	113477682	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr13:113477682T>A	ENST00000487903.1	+	9	837	c.749T>A	c.(748-750)cTg>cAg	p.L250Q	ATP11A_ENST00000283558.8_Missense_Mutation_p.L250Q|ATP11A_ENST00000375630.2_Missense_Mutation_p.L250Q|ATP11A_ENST00000375645.3_Missense_Mutation_p.L250Q			P98196	AT11A_HUMAN	ATPase, class VI, type 11A	250					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(12)|lung(17)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	51	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_lung(25;0.134)|all_epithelial(44;0.141)				GAAAACCTGCTGCTTAGAGGA	0.443000													30	60					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8420515	8420516	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:8420515_8420516delCA	ENST00000337907.3	-	19	3685_3686	c.3051_3052delTG	c.(3049-3054)ccccfs	p.PA1017fs	RERE_ENST00000400908.2_Frame_Shift_Del_p.PA1017fs|RERE_ENST00000400907.2_Intron|RERE_ENST00000476556.1_Frame_Shift_Del_p.PA463fs|RERE_ENST00000377464.1_Frame_Shift_Del_p.PA749fs	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	1017	Pro-rich.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		GGGTGGGAGGCAGGGGGCGGGG	0.718													2	4	---	---	---	---					
C1orf127	148345	broad.mit.edu	37	1	11008829	11008830	+	Frame_Shift_Ins	INS	-	-	G			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:11008829_11008830insG	ENST00000377004.4	-	12	1361_1362	c.1362_1363insC	c.(1360-1365)ccgagtfs	p.S455fs	C1orf127_ENST00000377008.4_Frame_Shift_Ins_p.S288fs	NM_001170754.1	NP_001164225.1	B7ZLG7	B7ZLG7_HUMAN	chromosome 1 open reading frame 127	306										NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(5)	32	Ovarian(185;0.249)	Lung NSC(185;0.000226)|all_lung(284;0.000302)|Renal(390;0.000469)|Colorectal(325;0.0062)|Breast(348;0.0139)|Hepatocellular(190;0.0305)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0731)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.71e-07)|COAD - Colon adenocarcinoma(227;7.79e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000305)|Kidney(185;0.000785)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|READ - Rectum adenocarcinoma(331;0.0509)		TGCACCACTCTGGGGAGAATGG	0.609													15	199	---	---	---	---					
UCHL5	51377	broad.mit.edu	37	1	192998709	192998709	+	Frame_Shift_Del	DEL	C	C	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:192998709delC	ENST00000367455.3	-	4	560	c.325delG	c.(325-327)agfs	p.E109fs	UCHL5_ENST00000367452.4_5'UTR|UCHL5_ENST00000367451.4_Frame_Shift_Del_p.E109fs|UCHL5_ENST00000530098.2_5'UTR|UCHL5_ENST00000367449.1_Frame_Shift_Del_p.E109fs|UCHL5_ENST00000367448.1_Frame_Shift_Del_p.E109fs|UCHL5_ENST00000367454.1_Frame_Shift_Del_p.E109fs	NM_015984.3	NP_057068.1	Q9Y5K5	UCHL5_HUMAN	ubiquitin carboxyl-terminal hydrolase L5	109					DNA recombination|DNA repair|protein deubiquitination|regulation of proteasomal protein catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytosol|Ino80 complex|proteasome complex	endopeptidase inhibitor activity|omega peptidase activity|proteasome binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(1)|lung(9)|ovary(1)	19						GATAATGTCTCGCCTAAATGG	0.328													16	58	---	---	---	---					
TRIM17	51127	broad.mit.edu	37	1	228596900	228596901	+	Frame_Shift_Ins	INS	-	-	TT			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:228596900_228596901insTT	ENST00000366697.2	-	5	1811_1812	c.855_856insAA	c.(853-858)ggagatfs	p.D286fs	TRIM17_ENST00000366698.2_Frame_Shift_Ins_p.D286fs|TRIM17_ENST00000295033.3_Frame_Shift_Ins_p.D286fs|TRIM17_ENST00000456946.2_Frame_Shift_Ins_p.D286fs|RP11-245P10.4_ENST00000436779.1_RNA			Q9Y577	TRI17_HUMAN	tripartite motif containing 17	286	B30.2/SPRY.				protein autoubiquitination	intracellular	protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)	10		Prostate(94;0.0724)				ACTTCAATCTGTCCGGGAACTC	0.604													8	508	---	---	---	---					
ARV1	64801	broad.mit.edu	37	1	231131630	231131631	+	Frame_Shift_Ins	INS	-	-	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:231131630_231131631insT	ENST00000310256.2	+	4	630_631	c.573_574insT	c.(571-576)cttgctfs	p.A192fs	ARV1_ENST00000497753.1_3'UTR|ARV1_ENST00000366658.2_Frame_Shift_Ins_p.A152fs	NM_022786.1	NP_073623.1	Q9H2C2	ARV1_HUMAN	ARV1 homolog (S. cerevisiae)	192					sphingolipid metabolic process	integral to membrane				breast(3)|large_intestine(2)|lung(2)	7	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)		COAD - Colon adenocarcinoma(196;0.211)|Colorectal(1306;0.233)		ACGGAAAACTCTTGCTGATTCC	0.391													79	143	---	---	---	---					
MTR	4548	broad.mit.edu	37	1	237024474	237024474	+	Frame_Shift_Del	DEL	A	A	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr1:237024474delA	ENST00000366577.5	+	20	2487	c.2093delA	c.(2092-2094)cafs	p.Q698fs	MTR_ENST00000535889.1_Intron	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	698	B12-binding N-terminal.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	AGGTTAAACCAAAAAAAATAT	0.308													7	107	---	---	---	---					
CAPN10	11132	broad.mit.edu	37	2	241534630	241534630	+	Frame_Shift_Del	DEL	C	C	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr2:241534630delC	ENST00000391984.2	+	7	1383	c.1187delC	c.(1186-1188)gcfs	p.A396fs	CAPN10_ENST00000404753.3_Frame_Shift_Del_p.A396fs|CAPN10_ENST00000270364.7_Intron|CAPN10_ENST00000354082.4_Frame_Shift_Del_p.A396fs|CAPN10_ENST00000352879.4_Intron|CAPN10_ENST00000391982.2_Frame_Shift_Del_p.A396fs	NM_023083.3	NP_075571.1	Q9HC96	CAN10_HUMAN	calpain 10	396	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		GCAGGCCGGGCCCGGGCACTG	0.632													32	90	---	---	---	---					
WWTR1	25937	broad.mit.edu	37	3	149238716	149238716	+	Frame_Shift_Del	DEL	A	A	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr3:149238716delA	ENST00000465804.1	-	8	1335	c.1079delT	c.(1078-1080)tcfs	p.F360fs	WWTR1_ENST00000467467.1_Frame_Shift_Del_p.F360fs|WWTR1_ENST00000360632.3_Frame_Shift_Del_p.F360fs	NM_001168278.1	NP_001161750.1	Q9GZV5	WWTR1_HUMAN	WW domain containing transcription regulator 1	360					hippo signaling cascade|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of protein kinase activity|negative regulation of protein phosphorylation|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|regulation of SMAD protein import into nucleus|stem cell division|transcription, DNA-dependent	cytoplasm	transcription coactivator activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	23			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			ACAGTCAAGGAAATCAGGGAA	0.408			T	CAMTA1	epitheliod hemangioendothelioma								56	205	---	---	---	---					
MAP1B	4131	broad.mit.edu	37	5	71494392	71494392	+	Frame_Shift_Del	DEL	C	C	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:71494392delC	ENST00000296755.7	+	5	5508	c.5210delC	c.(5209-5211)acfs	p.T1737fs		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1737						microtubule|microtubule associated complex	structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TCTGCTCATACCCCTTCTCAG	0.498													27	285	---	---	---	---					
PCDHA1	56147	broad.mit.edu	37	5	140166660	140166660	+	Frame_Shift_Del	DEL	C	C	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr5:140166660delC	ENST00000504120.2	+	1	785	c.785delC	c.(784-786)acfs	p.T263fs	PCDHA1_ENST00000394633.3_Frame_Shift_Del_p.T263fs|PCDHA1_ENST00000378133.3_Frame_Shift_Del_p.T263fs	NM_018900.2	NP_061723.1														breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(34)|prostate(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(3)	70			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACATTAGTGACCACATTAAAT	0.428													43	93	---	---	---	---					
MANEA	79694	broad.mit.edu	37	6	96054027	96054027	+	Frame_Shift_Del	DEL	G	G	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:96054027delG	ENST00000358812.4	+	5	1269	c.1135delG	c.(1135-1137)ggfs	p.G379fs		NM_024641.3	NP_078917.2	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	379	Catalytic (Probable).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			breast(2)|endometrium(3)|kidney(2)|liver(2)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		CCGAATCAATGGGAAGTATTA	0.428													42	150	---	---	---	---					
KLHL32	114792	broad.mit.edu	37	6	97512538	97512538	+	Frame_Shift_Del	DEL	T	T	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr6:97512538delT	ENST00000369261.4	+	5	710	c.347delT	c.(346-348)cafs	p.L116fs	KLHL32_ENST00000544166.1_5'UTR|KLHL32_ENST00000536676.1_Frame_Shift_Del_p.L80fs|KLHL32_ENST00000539200.1_Intron	NM_052904.3	NP_443136.2	Q96NJ5	KLH32_HUMAN	kelch-like family member 32	116										breast(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(13)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		CAGGATGTGCTAGCAGCGGGC	0.418													12	81	---	---	---	---					
SRRM3	222183	broad.mit.edu	37	7	75877533	75877534	+	Frame_Shift_Ins	INS	-	-	GT			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:75877533_75877534insGT	ENST00000388802.4	+	3	470_471	c.261_262insGT	c.(259-264)aatgggfs	p.NG87fs	SRRM3_ENST00000326382.8_Frame_Shift_Ins_p.NG87fs					serine/arginine repetitive matrix 3											NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|pancreas(1)	8						TTCGGCAGAAAGTGGGGACATT	0.609													12	42	---	---	---	---					
RBM33	155435	broad.mit.edu	37	7	155531073	155531074	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr7:155531073_155531074delCA	ENST00000401878.3	+	11	1911_1912	c.1713_1714delCA	c.(1711-1716)cccafs	p.PT571fs		NM_053043.2	NP_444271.2	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	571	Pro-rich.						nucleotide binding|RNA binding			breast(3)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	27	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		CGTTTCTGCCCACACACACACA	0.530													7	90	---	---	---	---					
PRSS55	203074	broad.mit.edu	37	8	10383167	10383167	+	Frame_Shift_Del	DEL	C	C	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr8:10383167delC	ENST00000328655.3	+	1	112	c.72delC	c.(70-72)ctfs	p.L24fs	PRSS51_ENST00000523024.1_RNA|PRSS55_ENST00000522210.1_Frame_Shift_Del_p.L24fs	NM_198464.3	NP_940866.2	Q6UWB4	PRS55_HUMAN	protease, serine, 55	24					proteolysis	integral to membrane	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)	31						GGACTCCTCTCCCAGAGGCTG	0.667													23	29	---	---	---	---					
TAF1L	138474	broad.mit.edu	37	9	32630337	32630337	+	Frame_Shift_Del	DEL	T	T	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr9:32630337delT	ENST00000242310.4	-	1	5330	c.5241delA	c.(5239-5241)gafs	p.E1749fs		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1749					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TTCCTTCCTCTTCATCTGCAA	0.483													33	155	---	---	---	---					
SCD	6319	broad.mit.edu	37	10	102107836	102107838	+	In_Frame_Del	DEL	ACC	ACC	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr10:102107836_102107838delACC	ENST00000370355.2	+	2	424_426	c.43_45delACC	c.(43-45)del	p.T19del		NM_005063.4	NP_005054.3	O00767	ACOD_HUMAN	stearoyl-CoA desaturase (delta-9-desaturase)	19					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			endometrium(1)|large_intestine(3)|lung(5)	9		Colorectal(252;0.0323)		Epithelial(162;1.97e-10)|all cancers(201;1.73e-08)		TAGCTCCTATACCACCACCACCA	0.581													7	227	---	---	---	---					
TRIM48	79097	broad.mit.edu	37	11	55032454	55032454	+	Frame_Shift_Del	DEL	G	G	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:55032454delG	ENST00000417545.2	+	2	209	c.123delG	c.(121-123)ccfs	p.P41fs		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	25						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						TCATAGACCCGGTCACCATAG	0.473													42	264	---	---	---	---					
OR8I2	120586	broad.mit.edu	37	11	55861308	55861308	+	Frame_Shift_Del	DEL	T	T	-	rs112181516		TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:55861308delT	ENST00000302124.2	+	1	556	c.525delT	c.(523-525)cafs	p.H175fs	OR8I2_ENST00000560768.1_Frame_Shift_Del_p.H175fs			Q8N0Y5	OR8I2_HUMAN	olfactory receptor, family 8, subfamily I, member 2	175					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.C178fs*2(1)		NS(1)|breast(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(24)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	53	Esophageal squamous(21;0.00693)					GCATCAATCATTTTTTTTGTG	0.443													7	218	---	---	---	---					
FOLH1B	219595	broad.mit.edu	37	11	89421671	89421671	+	RNA	DEL	G	G	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr11:89421671delG	ENST00000532352.1	+	0	1421							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						TAGTAAGAATGGGGTTTATTT	0.259													7	19	---	---	---	---					
KCNA1	3736	broad.mit.edu	37	12	5021141	5021141	+	Frame_Shift_Del	DEL	G	G	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr12:5021141delG	ENST00000382545.3	+	2	1704	c.597delG	c.(595-597)acfs	p.T199fs	KCNA1_ENST00000543874.2_Intron	NM_000217.2	NP_000208.2	Q09470	KCNA1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)	199					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			NS(1)|breast(3)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(23)|ovary(3)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	63					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	AGGACTTCACGGGCACCGTCC	0.537													10	66	---	---	---	---					
PRMT5	10419	broad.mit.edu	37	14	23393218	23393218	+	Splice_Site	DEL	T	T	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr14:23393218delT	ENST00000324366.8	-	12	1597	c.1375_splice	c.e12+1	p.K458_splice	PRMT5_ENST00000397440.4_Splice_Site_p.K287_splice|PRMT5-AS1_ENST00000599580.1_RNA|PRMT5_ENST00000397441.2_Splice_Site_p.K441_splice|PRMT5-AS1_ENST00000587245.2_RNA|PRMT5_ENST00000553897.1_Splice_Site_p.K414_splice|PRMT5_ENST00000538452.1_Splice_Site_p.K352_splice|PRMT5-AS1_ENST00000595662.1_RNA|PRMT5_ENST00000216350.8_Splice_Site_p.K397_splice|PRMT5-AS1_ENST00000590290.1_RNA	NM_006109.3	NP_006100.2	O14744	ANM5_HUMAN	protein arginine methyltransferase 5	458					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	25	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		TGGGGGCACCTTTTAGGAAGT	0.552													7	565	---	---	---	---					
TLE3	7090	broad.mit.edu	37	15	70347516	70347516	+	Frame_Shift_Del	DEL	C	C	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr15:70347516delC	ENST00000558939.1	-	15	2836	c.1459delG	c.(1459-1461)agfs	p.E487fs	TLE3_ENST00000317509.8_Frame_Shift_Del_p.E475fs|TLE3_ENST00000558379.1_Frame_Shift_Del_p.E482fs|TLE3_ENST00000539550.1_Frame_Shift_Del_p.E414fs|TLE3_ENST00000559191.1_Frame_Shift_Del_p.E68fs|TLE3_ENST00000559048.1_Frame_Shift_Del_p.E487fs|TLE3_ENST00000560589.1_Frame_Shift_Del_p.E431fs|TLE3_ENST00000557997.1_Frame_Shift_Del_p.E479fs|TLE3_ENST00000559929.1_Frame_Shift_Del_p.E497fs|TLE3_ENST00000560939.1_Frame_Shift_Del_p.E489fs|TLE3_ENST00000557907.1_Frame_Shift_Del_p.E479fs|TLE3_ENST00000440567.3_Frame_Shift_Del_p.E477fs|TLE3_ENST00000558201.1_Frame_Shift_Del_p.E493fs|TLE3_ENST00000451782.2_Frame_Shift_Del_p.E484fs|TLE3_ENST00000442299.2_Frame_Shift_Del_p.E479fs			Q04726	TLE3_HUMAN	transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)	487				E -> G (in Ref. 1; AAA61194).	organ morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						CACACCACCTCCCCGTGGCTG	0.662													66	108	---	---	---	---					
NLRC3	197358	broad.mit.edu	37	16	3599229	3599229	+	RNA	DEL	A	A	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr16:3599229delA	ENST00000301749.7	-	0	2925				NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000359128.5_RNA|NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000603507.1_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TCGAAGGCTGAAAAAAAAGGA	0.567													2	4	---	---	---	---					
CTB-91J4.1	0	broad.mit.edu	37	17	34445618	34445619	+	RNA	INS	-	-	C	rs66867561	by1000genomes	TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr17:34445618_34445619insC	ENST00000592460.1	+	0	41																											ACTGCCCCCCACCCCCCCACCC	0.599													2	4	---	---	---	---					
ROCK1P1	727758	broad.mit.edu	37	18	112519	112520	+	RNA	INS	-	-	A	rs140158594	by1000genomes	TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr18:112519_112520insA	ENST00000576266.1	+	0	153_154																											CCAGCTCCCCCGGGGCCTCCGT	0.530													4	6	---	---	---	---					
TCF4	6925	broad.mit.edu	37	18	52901794	52901795	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr18:52901794_52901795delGG	ENST00000354452.3	-	16	2081_2082	c.1470_1471delCC	c.(1468-1473)ccagfs	p.PQ490fs	TCF4_ENST00000537856.3_Frame_Shift_Del_p.PQ360fs|TCF4_ENST00000566279.1_Frame_Shift_Del_p.PQ430fs|TCF4_ENST00000540999.1_Frame_Shift_Del_p.PQ466fs|TCF4_ENST00000457482.3_Frame_Shift_Del_p.PQ330fs|TCF4_ENST00000568740.1_Frame_Shift_Del_p.PQ465fs|TCF4_ENST00000543082.1_Frame_Shift_Del_p.PQ448fs|TCF4_ENST00000568673.1_Frame_Shift_Del_p.PQ466fs|TCF4_ENST00000567880.1_Frame_Shift_Del_p.PQ430fs|TCF4_ENST00000561992.1_Frame_Shift_Del_p.PQ360fs|TCF4_ENST00000565018.2_Frame_Shift_Del_p.PQ490fs|TCF4_ENST00000537578.1_Frame_Shift_Del_p.PQ466fs|TCF4_ENST00000570177.2_Frame_Shift_Del_p.PQ360fs|TCF4_ENST00000564999.1_Frame_Shift_Del_p.PQ490fs|TCF4_ENST00000566286.1_Frame_Shift_Del_p.PQ487fs|TCF4_ENST00000564228.1_Frame_Shift_Del_p.PQ419fs|TCF4_ENST00000564403.2_Frame_Shift_Del_p.PQ496fs|TCF4_ENST00000356073.4_Frame_Shift_Del_p.PQ490fs|TCF4_ENST00000561831.3_Frame_Shift_Del_p.PQ330fs|TCF4_ENST00000570287.2_Frame_Shift_Del_p.PQ330fs|TCF4_ENST00000398339.1_Frame_Shift_Del_p.PQ592fs|TCF4_ENST00000544241.2_Frame_Shift_Del_p.PQ419fs	NM_001083962.1	NP_001077431.1	P15884	ITF2_HUMAN	transcription factor 4	490					positive regulation of neuron differentiation|protein-DNA complex assembly|transcription initiation from RNA polymerase II promoter	transcription factor complex	E-box binding|protein C-terminus binding|protein heterodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding RNA polymerase recruiting transcription factor activity|TFIIB-class binding transcription factor activity|TFIIB-class transcription factor binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	41				Colorectal(16;0.00108)|READ - Rectum adenocarcinoma(59;0.0649)|COAD - Colon adenocarcinoma(17;0.0718)		TAAGGGTCCTGGGGTGGGTTCA	0.569											OREG0024990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	141	---	---	---	---					
CTC-439O9.3	0	broad.mit.edu	37	19	31670636	31670638	+	RNA	DEL	GGT	GGT	-	rs139984397		TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:31670636_31670638delGGT	ENST00000589511.1	+	0	223																											gatgatggtaggtggtggtggtg	0.502													6	7	---	---	---	---					
ZIM2	23619	broad.mit.edu	37	19	57286106	57286107	+	Frame_Shift_Ins	INS	-	-	T			TCGA-99-8032-01A-11D-2238-08	TCGA-99-8032-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	786ce01c-7fa6-45de-b942-750d265d0430	1d500b69-b176-4d0e-acb3-1603dea479c5	g.chr19:57286106_57286107insT	ENST00000391708.3	-	12	2075_2076	c.1533_1534insA	c.(1531-1536)caattafs	p.L512fs	ZIM2_ENST00000221722.5_Frame_Shift_Ins_p.L512fs|ZIM2_ENST00000593711.1_Frame_Shift_Ins_p.L512fs|AC006115.3_ENST00000597946.1_RNA|AC006115.3_ENST00000595954.1_RNA|AC006115.3_ENST00000594400.1_RNA|ZIM2_ENST00000601070.1_Frame_Shift_Ins_p.L512fs|ZIM2_ENST00000599935.1_Frame_Shift_Ins_p.L512fs	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		AGTTGATAATGTTGAGTGAGGT	0.426													26	83	---	---	---	---					
