Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ACTRT2	140625	broad.mit.edu	37	1	2938971	2938971	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:2938971G>T	ENST00000378404.2	+	1	926	c.721G>T	c.(721-723)Gag>Tag	p.E241*		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	241						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		GGTCCTGAGGGAGTACAAGCT	0.657000													9	56					0.00621372	0.00680807	1	1	0
JAK2	3717	broad.mit.edu	37	9	5081771	5081771	+	Silent	SNP	A	A	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr9:5081771A>T	ENST00000381652.3	+	19	2975	c.2481A>T	c.(2479-2481)atA>atT	p.I827I	JAK2_ENST00000539801.1_Silent_p.I827I|JAK2_ENST00000544510.1_Silent_p.I678I|AL161450.1_ENST00000601793.1_Intron	NM_004972.3	NP_004963.1	O60674	JAK2_HUMAN	Janus kinase 2	827					actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)|ETV6/JAK2(11)|PCM1/JAK2(30)|PAX5/JAK2(18)	breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(32944)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(4)|skin(2)|urinary_tract(1)	32998	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		ATATGAGGATAGGTGCCCTGG	0.368000		1	"""T, Mis, O"""	"""ETV6, PCM1, BCR"""	"""ALL, AML, MPD,  CML"""				Polycythemia Vera, Familial				8	30					0	0	1	0	0
OR5D13	390142	broad.mit.edu	37	11	55540981	55540981	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr11:55540981C>A	ENST00000361760.1	+	1	68	c.68C>A	c.(67-69)cCa>cAa	p.P23Q		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	23					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				TCAGAATACCCAGAAATCCAG	0.373000													12	82					4.36969e-10	5.85724e-10	1	1	0
BPNT1	10380	broad.mit.edu	37	1	220232232	220232232	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:220232232T>A	ENST00000469520.2	-	10	1330	c.881A>T	c.(880-882)tAt>tTt	p.Y294F	BPNT1_ENST00000322067.7_Missense_Mutation_p.Y294F|BPNT1_ENST00000414869.2_Missense_Mutation_p.Y258F|BPNT1_ENST00000544404.1_Missense_Mutation_p.Y239F|BPNT1_ENST00000354807.3_Intron			O95861	BPNT1_HUMAN	3'(2'), 5'-bisphosphate nucleotidase 1	294					3'-phosphoadenosine 5'-phosphosulfate metabolic process|nervous system development|xenobiotic metabolic process	cytosol	3'(2'),5'-bisphosphate nucleotidase activity			breast(1)|endometrium(1)|large_intestine(1)|lung(9)|ovary(1)|skin(1)	14				GBM - Glioblastoma multiforme(131;0.0558)		TCGGCTTGCATAGTAGTCATA	0.453000													16	196					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134906618	134906618	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr10:134906618T>C	ENST00000607359.1	+	10	1889	c.1889T>C	c.(1888-1890)cTg>cCg	p.L630P	GPR123_ENST00000392607.3_Intron			Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	0						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		GACACCTCACTGTGCAGGAAA	0.622000													4	30					0	0	1	0	0
HAVCR1	26762	broad.mit.edu	37	5	156479590	156479590	+	Missense_Mutation	SNP	G	G	A	rs114193906	by1000genomes	TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr5:156479590G>A	ENST00000339252.3	-	3	987	c.455C>T	c.(454-456)aCg>aTg	p.T152M	HAVCR1_ENST00000523175.1_Missense_Mutation_p.T152M|HAVCR1_ENST00000544197.1_Missense_Mutation_p.T152M|HAVCR1_ENST00000425854.1_Missense_Mutation_p.T152M|HAVCR1_ENST00000522693.1_Missense_Mutation_p.T152M	NM_012206.2	NP_036338.2	Q96D42	HAVR1_HUMAN	hepatitis A virus cellular receptor 1	152	11 X 6 AA approximate tandem repeats of V-P-T-T-T-T].|Thr-rich.				interspecies interaction between organisms	integral to membrane	receptor activity			endometrium(3)|large_intestine(2)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGTCGTTGTCGTTGGAACAGT	0.473000													48	302					0	0	1	0	0
ZNF433	163059	broad.mit.edu	37	19	12127089	12127089	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr19:12127089T>C	ENST00000419886.2	-	5	779	c.488A>G	c.(487-489)tAt>tGt	p.Y163C	CTD-2006C1.2_ENST00000406892.2_RNA|CTD-2006C1.2_ENST00000476474.1_RNA|CTD-2006C1.2_ENST00000495324.1_RNA|ZNF433_ENST00000344980.6_Missense_Mutation_p.Y198C			Q8N7K0	ZN433_HUMAN	zinc finger protein 433	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.Y198C(1)		breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(1)|prostate(1)|skin(1)	14						TTTACACTTATAAGGTCCATC	0.383000													13	38					0	0	1	0	0
TSLP	85480	broad.mit.edu	37	5	110407596	110407596	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr5:110407596C>G	ENST00000344895.3	+	1	207	c.8C>G	c.(7-9)cCt>cGt	p.P3R	TSLP_ENST00000420978.2_Intron	NM_033035.4	NP_149024.1	Q969D9	TSLP_HUMAN	thymic stromal lymphopoietin	3				MFPFALLYVLS -> MKCLGQSKKEE (in Ref. 3; AAH40592).		extracellular space	cytokine activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|stomach(1)	11		all_cancers(142;2.72e-05)|all_epithelial(76;4.39e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0417)|Ovarian(225;0.0443)|Colorectal(57;0.0464)|all_lung(232;0.0507)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.24e-08)|Epithelial(69;1.54e-07)|all cancers(49;1.73e-05)|COAD - Colon adenocarcinoma(37;0.109)		CGTATGTTCCCTTTTGCCTTA	0.448000													22	77					0	0	1	0	0
MAZ	4150	broad.mit.edu	37	16	29821434	29821434	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr16:29821434C>T	ENST00000322945.6	+	5	1481	c.1316C>T	c.(1315-1317)gCa>gTa	p.A439V	MAZ_ENST00000563402.1_Silent_p.G95G|AC009133.20_ENST00000569039.1_RNA|MAZ_ENST00000562337.1_Missense_Mutation_p.A134V|MAZ_ENST00000545521.1_Missense_Mutation_p.A416V|AC009133.14_ENST00000569981.1_RNA|MAZ_ENST00000568282.1_3'UTR|MAZ_ENST00000568544.1_Missense_Mutation_p.A40V|MAZ_ENST00000566906.2_Intron|MAZ_ENST00000219782.6_3'UTR	NM_002383.2	NP_002374.2	P56270	MAZ_HUMAN	MYC-associated zinc finger protein (purine-binding transcription factor)	439	Poly-Ala.				regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription|transcription initiation from RNA polymerase II promoter	nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			endometrium(3)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						gcggcagcggcagcggcggca	0.667000													11	44					0	0	1	0	0
C10orf88	80007	broad.mit.edu	37	10	124697613	124697613	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr10:124697613C>T	ENST00000481909.1	-	5	935	c.711G>A	c.(709-711)atG>atA	p.M237I	C10orf88_ENST00000368891.5_5'UTR	NM_024942.3	NP_079218.2	Q9H8K7	CJ088_HUMAN	chromosome 10 open reading frame 88	237										breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)	18		all_neural(114;0.0765)|Lung NSC(174;0.163)|all_lung(145;0.205)		Colorectal(40;0.0686)|COAD - Colon adenocarcinoma(40;0.0735)		GTAGTCCAATCATATGCTTGT	0.388000													15	101					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192700850	192700850	+	Silent	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:192700850C>T	ENST00000304141.4	-	2	1406	c.1077G>A	c.(1075-1077)gcG>gcA	p.A359A		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	359						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	CCCTGGAGGTCGCCTTCTCAG	0.572000													7	190					0	0	1	0	0
CATSPER1	117144	broad.mit.edu	37	11	65793793	65793793	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr11:65793793C>T	ENST00000312106.5	-	1	195	c.58G>A	c.(58-60)Gat>Aat	p.D20N		NM_053054.3	NP_444282.3	Q8NEC5	CTSR1_HUMAN	cation channel, sperm associated 1	20					cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	protein binding			breast(3)|central_nervous_system(1)|endometrium(9)|kidney(3)|large_intestine(6)|liver(3)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	44						AAGAACCTATCTGCGTTATTG	0.547000													20	107					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1670116	1670116	+	Silent	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:1670116C>A	ENST00000252804.4	-	10	1211	c.1161G>T	c.(1159-1161)ccG>ccT	p.P387P	PXDN_ENST00000483018.1_5'UTR	NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	387	Ig-like C2-type 2.				extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		TGTTCACCCGCGGGTCAACTG	0.632000													11	61					0.0242445	0.0258882	1	1	0
OR3A3	8392	broad.mit.edu	37	17	3324273	3324273	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr17:3324273C>A	ENST00000291231.1	+	1	412	c.412C>A	c.(412-414)Ccc>Acc	p.P138T		NM_012373.2	NP_036505.2	P47888	OR3A3_HUMAN	olfactory receptor, family 3, subfamily A, member 3	138					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(3)|prostate(1)	9						CATCTGCCAGCCCCTCACCTA	0.617000													34	73					1.4374e-25	2.24984e-25	1	1	0
PTDSS1	9791	broad.mit.edu	37	8	97345788	97345788	+	Silent	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr8:97345788G>A	ENST00000517309.1	+	13	1742	c.1416G>A	c.(1414-1416)aaG>aaA	p.K472K	PTDSS1_ENST00000522072.1_Intron|PTDSS1_ENST00000455950.2_Silent_p.K326K	NM_014754.1	NP_055569.1	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	472					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|stomach(1)	29	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	GCGTTGGAAAGAAATGAAAAA	0.493000											OREG0018880	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	64					0	0	1	0	0
APOH	350	broad.mit.edu	37	17	64210622	64210622	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr17:64210622C>A	ENST00000205948.6	-	7	968	c.931G>T	c.(931-933)Gag>Tag	p.E311*		NM_000042.2	NP_000033.2	P02749	APOH_HUMAN	apolipoprotein H (beta-2-glycoprotein I)	311	Sushi-like.				blood coagulation, intrinsic pathway|negative regulation of angiogenesis|negative regulation of blood coagulation|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of myeloid cell apoptosis|negative regulation of smooth muscle cell apoptosis|plasminogen activation|positive regulation of lipoprotein lipase activity|triglyceride metabolic process|triglyceride transport	cell surface|chylomicron|high-density lipoprotein particle|very-low-density lipoprotein particle	eukaryotic cell surface binding|glycoprotein binding|heparin binding|lipoprotein lipase activator activity|phospholipid binding			central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(6;9.74e-08)			TGAGCATCCTCTGTATAGCTA	0.403000													18	81					1.15919e-05	1.37143e-05	1	1	0
ESR1	2099	broad.mit.edu	37	6	152129053	152129053	+	Silent	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr6:152129053C>A	ENST00000440973.1	+	3	376	c.6C>A	c.(4-6)acC>acA	p.T2T	ESR1_ENST00000443427.1_Silent_p.T2T|ESR1_ENST00000206249.3_Silent_p.T2T|ESR1_ENST00000406599.1_Silent_p.T2T|ESR1_ENST00000456483.2_Silent_p.T2T|ESR1_ENST00000338799.5_Silent_p.T2T	NM_001122742.1	NP_001116214.1	P03372	ESR1_HUMAN	estrogen receptor 1	2	Modulating; mediates interaction with MACROD1.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(19)|ovary(1)|prostate(2)|skin(1)	49		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	GGACCATGACCATGACCCTCC	0.642000													5	35					3.59834e-05	4.17871e-05	1	1	0
GCNT2	2651	broad.mit.edu	37	6	10586826	10586826	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr6:10586826G>T	ENST00000265012.4	+	1	848	c.604G>T	c.(604-606)Gag>Tag	p.E202*	GCNT2_ENST00000379597.3_Intron|GCNT2_ENST00000316170.3_Intron|GCNT2_ENST00000397423.2_Intron|GCNT2_ENST00000410107.1_Intron|GCNT2_ENST00000495262.1_Intron	NM_145655.3	NP_663630.2	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	202						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		AACCAACCGGGAGATAGTTCA	0.488000													18	67					5.26018e-13	7.53162e-13	1	1	0
C2orf62	375307	broad.mit.edu	37	2	219232586	219232586	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:219232586G>A	ENST00000289388.3	+	10	1092	c.1063G>A	c.(1063-1065)Gac>Aac	p.D355N	C2orf62_ENST00000481940.1_3'UTR	NM_198559.1	NP_940961.1	Q7Z7H3	CB062_HUMAN	chromosome 2 open reading frame 62	355										endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	16		Renal(207;0.0915)		Epithelial(149;8.08e-07)|all cancers(144;0.000146)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGGCCCCTTCGACCCGTGGCG	0.716000													9	47					0	0	1	0	0
EXOC4	60412	broad.mit.edu	37	7	133160209	133160209	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr7:133160209C>T	ENST00000253861.4	+	8	1339	c.1310C>T	c.(1309-1311)cCa>cTa	p.P437L	EXOC4_ENST00000539845.1_Missense_Mutation_p.P336L|EXOC4_ENST00000393161.2_Missense_Mutation_p.P437L	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	437					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				CCTCAAAGGCCAAAAAATTCT	0.368000													10	97					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90074370	90074370	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr5:90074370C>T	ENST00000405460.2	+	63	12889	c.12793C>T	c.(12793-12795)Ccc>Tcc	p.P4265S		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	4265					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CAGCGACTCTCCCTATGGCCG	0.438000													14	47					0	0	1	0	0
ZNF107	51427	broad.mit.edu	37	7	64167291	64167291	+	Silent	SNP	T	T	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr7:64167291T>C	ENST00000395391.1	+	4	1984	c.609T>C	c.(607-609)ctT>ctC	p.L203L	ZNF107_ENST00000344930.3_Silent_p.L203L|ZNF107_ENST00000423627.1_Silent_p.L203L			Q9UII5	ZN107_HUMAN	zinc finger protein 107	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(18)|ovary(1)|stomach(1)	37		Lung NSC(55;0.00948)|all_lung(88;0.0249)				CCTCACACCTTACTATACATA	0.373000													4	54					0	0	1	0	0
LOC339874	339874	broad.mit.edu	37	3	131080958	131080958	+	RNA	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr3:131080958C>T	ENST00000502521.1	-	0	239				NUDT16P_ENST00000499077.2_RNA	NR_038976.1																						GGCCTTGCACCTTCCTTGCGG	0.667000													2	1					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43579514	43579514	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr15:43579514C>G	ENST00000452443.2	-	6	833	c.829G>C	c.(829-831)Gga>Cga	p.G277R		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	277					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	CAGCACTGTCCGTACTTCACA	0.557000													4	30					0	0	1	0	0
IDE	3416	broad.mit.edu	37	10	94223586	94223586	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr10:94223586G>T	ENST00000265986.6	-	21	2719	c.2663C>A	c.(2662-2664)gCa>gAa	p.A888E	IDE_ENST00000371581.5_Missense_Mutation_p.A333E|IDE_ENST00000496903.1_5'UTR	NM_004969.3	NP_004960.2	P14735	IDE_HUMAN	insulin-degrading enzyme	888					beta-amyloid metabolic process|bradykinin catabolic process|interspecies interaction between organisms|sex differentiation	cell surface|extracellular space|soluble fraction	ATP binding|metalloendopeptidase activity|protein homodimerization activity|signal transducer activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(10)|ovary(2)|urinary_tract(2)	33					Bacitracin(DB00626)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AATTGCTAATGCCTGAATGTG	0.423000													24	84					3.73988e-18	5.67741e-18	1	1	0
CROT	54677	broad.mit.edu	37	7	86991070	86991070	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr7:86991070G>T	ENST00000331536.3	+	6	634	c.449G>T	c.(448-450)gGa>gTa	p.G150V	CROT_ENST00000442291.1_Missense_Mutation_p.G150V|CROT_ENST00000419147.2_Missense_Mutation_p.G178V	NM_021151.3	NP_066974.2	Q9UKG9	OCTC_HUMAN	carnitine O-octanoyltransferase	150					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	CATAAAGTTGGAAATACTCCT	0.328000													8	54					0.0581538	0.0613169	1	1	0
ASB17	127247	broad.mit.edu	37	1	76397866	76397866	+	Silent	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:76397866C>T	ENST00000284142.6	-	1	250	c.111G>A	c.(109-111)caG>caA	p.Q37Q		NM_080868.2	NP_543144.1	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box containing 17	37					intracellular signal transduction					breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	21						GATATCCCCACTGACCCAAAA	0.393000													6	76					0	0	1	0	0
TCHH	7062	broad.mit.edu	37	1	152082220	152082220	+	Missense_Mutation	SNP	G	G	C	rs113946258		TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:152082220G>C	ENST00000368804.1	-	2	3472	c.3473C>G	c.(3472-3474)cCg>cGg	p.P1158R		NM_007113.2	NP_009044.2	Q07283	TRHY_HUMAN	trichohyalin	1158	10 X 30 AA tandem repeats.				keratinization	cytoskeleton	calcium ion binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(20)|kidney(9)|large_intestine(16)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(4)	105	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCTCTTCTCCGGTTCCTCTCT	0.592000													3	116					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7651536	7651536	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr12:7651536A>G	ENST00000359156.4	-	4	908	c.706T>C	c.(706-708)Tgg>Cgg	p.W236R	CD163_ENST00000396620.3_Missense_Mutation_p.W236R|CD163_ENST00000432237.2_Missense_Mutation_p.W236R|CD163_ENST00000541972.1_Missense_Mutation_p.W224R	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	236	SRCR 2.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						TTGCAGTTCCAGAGAGCTGAC	0.433000													35	160					0	0	1	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68964644	68964644	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr4:68964644C>A	ENST00000356291.2	-	2	183	c.124G>T	c.(124-126)Gga>Tga	p.G42*		NM_207407.2	NP_997290.2	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	42					proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(4)	39						ATTGCAATTCCTATGATTGCT	0.383000													11	60					2.23348e-06	2.70595e-06	1	1	0
RPS6KB1	6198	broad.mit.edu	37	17	58024113	58024113	+	Silent	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr17:58024113C>T	ENST00000225577.4	+	15	1563	c.1542C>T	c.(1540-1542)atC>atT	p.I514I	RPS6KB1_ENST00000393021.3_Silent_p.I461I|RPS6KB1_ENST00000443572.2_Silent_p.I491I|RPS6KB1_ENST00000406116.3_Intron|RP11-178C3.1_ENST00000591035.1_Intron	NM_001272042.1|NM_001272044.1|NM_001272060.1|NM_003161.2	NP_001258971.1|NP_001258973.1|NP_001258989.1|NP_003152.1	P23443	KS6B1_HUMAN	ribosomal protein S6 kinase, 70kDa, polypeptide 1	514	Autoinhibitory domain.				apoptosis|G1/S transition of mitotic cell cycle|insulin receptor signaling pathway|negative regulation of apoptosis|phosphatidylinositol-mediated signaling|positive regulation of mitotic cell cycle|positive regulation of translational initiation|TOR signaling cascade	cell junction|cytoplasm|cytosol|mitochondrial outer membrane|nucleus|synapse|synaptosome	ATP binding|protein binding|protein kinase activity			endometrium(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	14	all_cancers(5;1.63e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;3.57e-12)|all cancers(12;6.41e-11)			TTCCCATGATCTCCAAACGGC	0.468000													13	70					0	0	1	0	0
KIF26A	26153	broad.mit.edu	37	14	104642556	104642556	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr14:104642556G>T	ENST00000315264.7	+	11	3392	c.3014G>T	c.(3013-3015)gGg>gTg	p.G1005V	KIF26A_ENST00000423312.2_Missense_Mutation_p.G1144V			Q9ULI4	KI26A_HUMAN	kinesin family member 26A	1144					blood coagulation|enteric nervous system development|microtubule-based movement|negative regulation of signal transduction|regulation of cell growth by extracellular stimulus	cytosol|microtubule	ATP binding|microtubule binding|microtubule motor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	21		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0767)	Epithelial(46;0.152)	Epithelial(152;0.161)		CTTGACCCTGGGGGCCCCCCT	0.701000													6	3					0.000157383	0.000181099	1	1	0
FBN2	2201	broad.mit.edu	37	5	127712545	127712545	+	Splice_Site	SNP	A	A	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr5:127712545A>G	ENST00000508053.1	-	20	2825	c.1849_splice	c.e20-1	p.D617_splice	FBN2_ENST00000511489.1_5'UTR|FBN2_ENST00000262464.4_Splice_Site_p.D617_splice|FBN2_ENST00000508989.1_Splice_Site_p.D584_splice			P35556	FBN2_HUMAN	fibrillin 2	617	EGF-like 9; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		ATTCATCATGATCTGCAGAAG	0.428000													14	97					0	0	1	0	0
LPCAT1	79888	broad.mit.edu	37	5	1474094	1474094	+	Missense_Mutation	SNP	T	T	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr5:1474094T>G	ENST00000283415.3	-	11	1289	c.1157A>C	c.(1156-1158)gAc>gCc	p.D386A		NM_024830.3	NP_079106.3	Q8NF37	PCAT1_HUMAN	lysophosphatidylcholine acyltransferase 1	386	EF-hand 1.				phospholipid biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	1-acylglycerophosphocholine O-acyltransferase activity|1-alkylglycerophosphocholine O-acetyltransferase activity|calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30			OV - Ovarian serous cystadenocarcinoma(19;0.0274)|all cancers(22;0.0534)	GBM - Glioblastoma multiforme(108;0.156)		TGAAAACATGTCTTCCAGCAA	0.507000													14	47					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128680401	128680401	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr11:128680401G>T	ENST00000344954.6	+	9	1166	c.778G>T	c.(778-780)Gac>Tac	p.D260Y	FLI1_ENST00000534087.1_Missense_Mutation_p.D260Y|FLI1_ENST00000281428.8_Missense_Mutation_p.D227Y|FLI1_ENST00000525560.1_Missense_Mutation_p.D100Y|FLI1_ENST00000429175.2_Missense_Mutation_p.D293Y			Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	293					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		GCTGCTCTCCGACAGCGCCAA	0.627000			T	EWSR1	Ewing sarcoma								4	8					1	1	1	1	0
SLC45A2	51151	broad.mit.edu	37	5	33944811	33944811	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr5:33944811G>C	ENST00000296589.4	-	7	1681	c.1535C>G	c.(1534-1536)tCt>tGt	p.S512C	SLC45A2_ENST00000342059.3_Missense_Mutation_p.S453C	NM_016180.3	NP_057264.3	Q9UMX9	S45A2_HUMAN	solute carrier family 45, member 2	512					melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(25)|ovary(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48						TGCCACCGCAGACGCTGTGAT	0.532000													5	63					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31437429	31437429	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr16:31437429C>T	ENST00000389202.2	+	30	3515	c.3466C>T	c.(3466-3468)Cca>Tca	p.P1156S		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	1156					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CTGTGTGGCCCCAAATGTGCC	0.463000													5	25					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140503619	140503619	+	Missense_Mutation	SNP	C	C	A	rs139674355		TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr5:140503619C>A	ENST00000194152.1	+	1	2039	c.2039C>A	c.(2038-2040)gCc>gAc	p.A680D		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		680					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGGCCCAGGCCCAGGCCGAC	0.706000													37	107					8.20599e-20	1.26866e-19	1	1	0
CREBBP	1387	broad.mit.edu	37	16	3779779	3779779	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr16:3779779C>A	ENST00000262367.5	-	31	6078	c.5269G>T	c.(5269-5271)Ggc>Tgc	p.G1757C	CREBBP_ENST00000382070.3_Missense_Mutation_p.G1719C	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1757	Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGTGGCTCGCCCTGGCTGCTG	0.627000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						5	15					0.00116845	0.00129713	1	1	0
CSMD1	64478	broad.mit.edu	37	8	2820144	2820144	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr8:2820144G>T	ENST00000520002.1	-	62	10030	c.9475C>A	c.(9475-9477)Cct>Act	p.P3159T	CSMD1_ENST00000537824.1_Missense_Mutation_p.P3158T|CSMD1_ENST00000602723.1_Missense_Mutation_p.P2982T|CSMD1_ENST00000400186.3_Missense_Mutation_p.P2982T|CSMD1_ENST00000602557.1_Missense_Mutation_p.P3159T|CSMD1_ENST00000542608.1_Missense_Mutation_p.P2981T			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3159	Sushi 26.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GGGATGCCAGGGTCTCCGCAG	0.483000													5	16					2.0095e-06	2.45822e-06	1	1	0
CDH9	1007	broad.mit.edu	37	5	26902731	26902731	+	Silent	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr5:26902731C>A	ENST00000231021.4	-	7	1279	c.1107G>T	c.(1105-1107)gtG>gtT	p.V369V		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	369	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						ATATTTTGACCACAGCTGTAT	0.388000													43	53					5.2118e-15	7.59175e-15	1	1	0
ZNF570	148268	broad.mit.edu	37	19	37975236	37975236	+	Nonsense_Mutation	SNP	A	A	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr19:37975236A>T	ENST00000330173.1	+	5	1241	c.712A>T	c.(712-714)Aga>Tga	p.R238*	ZNF570_ENST00000388801.3_Nonsense_Mutation_p.R35*|ZNF570_ENST00000586475.1_Nonsense_Mutation_p.R294*	NM_144694.1	NP_653295.1	Q96NI8	ZN570_HUMAN	zinc finger protein 570	238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(1)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TCTTCATCAAAGAATTCATAC	0.393000													31	102					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	57					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186120875	186120875	+	Splice_Site	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:186120875G>T	ENST00000271588.4	+	95	15125	c.14896_splice	c.e95+1	p.G4966_splice	HMCN1_ENST00000367492.2_Splice_Site_p.G4966_splice	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	4966	Nidogen G2 beta-barrel.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						ATTTGCAACTGGTTAGTGTCA	0.348000													39	86					5.48756e-27	8.69727e-27	1	1	0
NUFIP2	57532	broad.mit.edu	37	17	27621006	27621006	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr17:27621006C>A	ENST00000225388.4	-	1	130	c.72G>T	c.(70-72)caG>caT	p.Q24H	NUFIP2_ENST00000579665.1_Missense_Mutation_p.Q24H	NM_020772.2	NP_065823.1	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein interacting protein 2	24	His-rich.					nucleus|polysomal ribosome	protein binding|RNA binding	p.Q24_Q25delQQ(1)		breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	24			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			gctgctgctgctgagggtgat	0.597000													3	39					1	1	1	1	0
SLC45A1	50651	broad.mit.edu	37	1	8390300	8390300	+	Silent	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:8390300C>T	ENST00000471889.1	+	5	1132	c.747C>T	c.(745-747)ggC>ggT	p.G249G	SLC45A1_ENST00000289877.8_Silent_p.G249G|SLC45A1_ENST00000377479.2_Silent_p.G283G			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	249					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		ACGTGGTCGGCGGAATCCACT	0.622000													13	113					0	0	1	0	0
IGHV1OR16-4	28312	broad.mit.edu	37	16	33013863	33013863	+	RNA	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr16:33013863G>T	ENST00000567619.1	-	0	499																											TCTCCTGCCAGGCTTCTGGAT	0.557000													16	152					2.37509e-13	3.42013e-13	1	1	0
OFD1	8481	broad.mit.edu	37	X	13764451	13764451	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chrX:13764451G>T	ENST00000380567.1	+	8	983	c.111G>T	c.(109-111)caG>caT	p.Q37H	OFD1_ENST00000340096.6_Missense_Mutation_p.Q177H|OFD1_ENST00000490265.1_3'UTR|OFD1_ENST00000398395.3_Missense_Mutation_p.Q177H|OFD1_ENST00000380550.3_Missense_Mutation_p.Q177H			O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	177					cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	25						AGAAGCTTCAGCTTATTGATG	0.373000													4	27					0.014758	0.0158932	1	1	0
ZFP30	22835	broad.mit.edu	37	19	38126627	38126627	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr19:38126627C>A	ENST00000351218.2	-	6	1372	c.815G>T	c.(814-816)tGt>tTt	p.C272F	ZFP30_ENST00000392144.1_Missense_Mutation_p.C272F|ZFP30_ENST00000514101.2_Missense_Mutation_p.C272F|ZFP30_ENST00000589018.1_Intron	NM_014898.2	NP_055713.1	Q9Y2G7	ZFP30_HUMAN	ZFP30 zinc finger protein	272					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	21			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACATTCTTTACATTCATAGGG	0.433000													10	63					2.68362e-12	3.73631e-12	1	1	0
OR8U1	219417	broad.mit.edu	37	11	56143603	56143603	+	Nonsense_Mutation	SNP	T	T	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr11:56143603T>A	ENST00000302270.1	+	1	504	c.504T>A	c.(502-504)taT>taA	p.Y168*		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1											NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					GCCTCTCCTATTGCCACTCCA	0.453000													58	367					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234854514	234854514	+	Silent	SNP	C	C	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:234854514C>G	ENST00000324695.4	+	7	754	c.714C>G	c.(712-714)gcC>gcG	p.A238A	TRPM8_ENST00000433712.2_5'UTR	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	238						integral to membrane		p.A238A(1)		breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	ATTTTTTAGCCCAGTACCTTA	0.388000													12	88					0	0	1	0	0
PRSS58	136541	broad.mit.edu	37	7	141954928	141954928	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr7:141954928G>T	ENST00000552471.1	-	3	702	c.383C>A	c.(382-384)tCt>tAt	p.S128Y	PRSS58_ENST00000547058.2_Missense_Mutation_p.S128Y			Q8IYP2	PRS58_HUMAN	protease, serine, 58	128	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						GGTATTTTCAGAGATAGTTTG	0.403000													31	102					5.59293e-11	7.61847e-11	1	1	0
RICTOR	253260	broad.mit.edu	37	5	38950545	38950545	+	Silent	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr5:38950545C>T	ENST00000357387.3	-	31	3435	c.3405G>A	c.(3403-3405)acG>acA	p.T1135T	RICTOR_ENST00000296782.5_Silent_p.T1135T	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	1135					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					CACTGGGCTCCGTAAGTGTTC	0.368000													16	149					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367738	145367738	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:145367738A>G	ENST00000342960.5	+	83	10369	c.10334A>G	c.(10333-10335)aAa>aGa	p.K3445R	NBPF10_ENST00000369338.1_Intron|NBPF10_ENST00000369339.2_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		gggaaggggaaaaaaagaagg	0.413000													4	40					0	0	1	0	0
FZD10	11211	broad.mit.edu	37	12	130648608	130648608	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr12:130648608G>C	ENST00000539839.1	+	1	1605	c.1023G>C	c.(1021-1023)caG>caC	p.Q341H	FZD10_ENST00000229030.4_Missense_Mutation_p.R374T	NM_007197.3	NP_009128.1	Q9ULW2	FZD10_HUMAN	frizzled family receptor 10	0					brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|pancreas(1)|prostate(3)|urinary_tract(1)	35	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		GTCATGCGCAGGGTGGCGGGG	0.657000													22	85					0	0	1	0	0
PEX1	5189	broad.mit.edu	37	7	92147008	92147008	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr7:92147008T>C	ENST00000248633.4	-	5	916	c.821A>G	c.(820-822)aAa>aGa	p.K274R	PEX1_ENST00000438045.1_Intron|PEX1_ENST00000428214.1_Missense_Mutation_p.K274R	NM_000466.2	NP_000457.1	O43933	PEX1_HUMAN	peroxisomal biogenesis factor 1	274					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			CTGCATATTTTTGAATGCATT	0.353000													8	29					0	0	1	0	0
S100A7	6278	broad.mit.edu	37	1	153430337	153430337	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:153430337G>A	ENST00000368723.3	-	3	361	c.251C>T	c.(250-252)aCa>aTa	p.T84I	S100A7_ENST00000368722.1_Missense_Mutation_p.T84I	NM_002963.3	NP_002954.2	P31151	S10A7_HUMAN	S100 calcium binding protein A7	84	EF-hand 2.				angiogenesis|defense response to Gram-negative bacterium|innate immune response|keratinocyte differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|response to lipopolysaccharide|response to reactive oxygen species|sequestering of metal ion	cytosol|endoplasmic reticulum|extracellular region|focal adhesion|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			breast(1)|large_intestine(2)|lung(5)|skin(2)	10	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GTGGTAGTCTGTGGCTATGTC	0.517000													25	96					0	0	1	0	0
PITRM1	10531	broad.mit.edu	37	10	3206026	3206026	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr10:3206026C>A	ENST00000380989.2	-	7	720	c.682G>T	c.(682-684)Gac>Tac	p.D228Y	PITRM1_ENST00000451104.2_Missense_Mutation_p.D196Y|PITRM1_ENST00000224949.4_Missense_Mutation_p.D228Y|PITRM1-AS1_ENST00000601046.1_RNA|PITRM1-AS1_ENST00000598280.1_RNA	NM_001242307.1|NM_014889.3	NP_001229236.1|NP_055704.2	E7ES23	E7ES23_HUMAN	pitrilysin metallopeptidase 1	196					proteolysis		metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|urinary_tract(3)	33						TACGTGTGGTCAGGAAGAAGT	0.443000													4	43					0.150653	0.156879	1	1	0
TCL6	27004	broad.mit.edu	37	14	96134605	96134605	+	RNA	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr14:96134605C>A	ENST00000467865.1	+	0	1821				RP11-1070N10.6_ENST00000461160.1_RNA																large_intestine(1)|lung(7)	8		all_cancers(154;0.103)		Epithelial(152;0.0655)|all cancers(159;0.149)|BRCA - Breast invasive adenocarcinoma(234;0.206)|COAD - Colon adenocarcinoma(157;0.207)		GTTGCTGGTTCTTTGCAGCAG	0.507000			T	TRA@	T-ALL								16	52					1.01871e-10	1.38019e-10	1	1	0
PLEKHO2	80301	broad.mit.edu	37	15	65157235	65157235	+	Silent	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr15:65157235C>T	ENST00000323544.4	+	6	749	c.621C>T	c.(619-621)acC>acT	p.T207T	AC069368.3_ENST00000437723.1_Intron	NM_001195059.1|NM_025201.4	NP_001181988.1|NP_079477.2	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O member 2	207	Pro-rich.									NS(1)|breast(1)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	25						TGCCTCCTACCAAGCCTTTCC	0.612000													37	114					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170027086	170027086	+	Silent	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:170027086C>T	ENST00000263816.3	-	59	11640	c.11355G>A	c.(11353-11355)ggG>ggA	p.G3785G		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3785	LDL-receptor class A 32.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CTGAGTTGTCCCCACAGTCGT	0.473000													10	132					0	0	1	0	0
KCNH1	3756	broad.mit.edu	37	1	211192176	211192176	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:211192176C>A	ENST00000271751.4	-	6	1008	c.981G>T	c.(979-981)aaG>aaT	p.K327N	KCNH1_ENST00000367007.4_Intron			O95259	KCNH1_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 1	327					myoblast fusion|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	calmodulin binding|delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|lung(35)|ovary(4)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				OV - Ovarian serous cystadenocarcinoma(81;0.0109)|all cancers(67;0.141)|Epithelial(68;0.185)		CAAAACCAATCTTCCCTGGAT	0.458000													4	161					0.0215528	0.0231119	1	1	0
IDNK	414328	broad.mit.edu	37	9	86258454	86258454	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr9:86258454C>A	ENST00000277124.8	+	6	1030	c.185C>A	c.(184-186)tCg>tAg	p.S62*	IDNK_ENST00000405990.3_3'UTR|IDNK_ENST00000376419.4_Nonsense_Mutation_p.S108*|IDNK_ENST00000376417.4_3'UTR|IDNK_ENST00000454393.1_Nonsense_Mutation_p.S151*	NM_001256915.1	NP_001243844.1	Q5T6J7	GNTK_HUMAN	idnK, gluconokinase homolog (E. coli)	108					carbohydrate metabolic process	cytoplasm	ATP binding|gluconokinase activity|shikimate kinase activity										TGTGAGGAGTCGGGAAAGGAA	0.507000													18	28					5.03518e-11	6.9337e-11	1	1	0
CPA3	1359	broad.mit.edu	37	3	148596298	148596298	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr3:148596298C>T	ENST00000296046.3	+	4	392	c.340C>T	c.(340-342)Cac>Tac	p.H114Y	RP11-680B3.2_ENST00000488190.1_RNA	NM_001870.2	NP_001861.2	P15088	CBPA3_HUMAN	carboxypeptidase A3 (mast cell)	114					proteolysis	stored secretory granule|transport vesicle	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CCCAGGCAGGCACAGCTACGC	0.318000													15	35					0	0	1	0	0
ADAM15	8751	broad.mit.edu	37	1	155030407	155030407	+	Silent	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:155030407G>A	ENST00000356955.2	+	14	1598	c.1497G>A	c.(1495-1497)caG>caA	p.Q499Q	ADAM15_ENST00000449910.2_Silent_p.Q499Q|ADAM15_ENST00000355956.2_Silent_p.Q499Q|ADAM15_ENST00000368410.2_Silent_p.Q205Q|ADAM15_ENST00000531455.1_Silent_p.Q509Q|ADAM15_ENST00000271836.6_Silent_p.Q499Q|ADAM15_ENST00000360674.4_Silent_p.Q499Q|ADAM15_ENST00000359280.4_Silent_p.Q499Q|ADAM15_ENST00000368412.3_Silent_p.Q499Q|ADAM15_ENST00000447332.3_Silent_p.Q483Q|ADAM15_ENST00000368413.1_Silent_p.Q205Q|ADAM15_ENST00000472434.1_3'UTR	NM_207197.2	NP_997080.1	Q13444	ADA15_HUMAN	ADAM metallopeptidase domain 15	499	Disintegrin.				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(5)|urinary_tract(1)	39	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			ACAGCTCCCAGTGTCCCCCTG	0.637000													7	162					0	0	1	0	0
CEBPZ	10153	broad.mit.edu	37	2	37455252	37455252	+	Nonsense_Mutation	SNP	T	T	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:37455252T>A	ENST00000234170.5	-	2	1229	c.1084A>T	c.(1084-1086)Aaa>Taa	p.K362*		NM_005760.2	NP_005751.2	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein (C/EBP), zeta	362					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			breast(3)|endometrium(2)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28		all_hematologic(82;0.21)				GCTCGAGTTTTAGTGGTTACT	0.408000													10	37					0	0	1	0	0
S100PBP	64766	broad.mit.edu	37	1	33292201	33292201	+	Silent	SNP	G	G	A	rs12092326		TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:33292201G>A	ENST00000373475.5	+	3	755	c.501G>A	c.(499-501)tcG>tcA	p.S167S	S100PBP_ENST00000398243.3_Silent_p.S167S|S100PBP_ENST00000373476.1_Silent_p.S167S|S100PBP_ENST00000356689.3_3'UTR	NM_022753.3	NP_073590.2	Q96BU1	S1PBP_HUMAN	S100P binding protein	167						nucleus	calcium-dependent protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|stomach(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				AGACTGATTCGTCCAAAGATA	0.393000													31	36					0	0	1	0	0
EBF3	253738	broad.mit.edu	37	10	131761981	131761981	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr10:131761981C>G	ENST00000368648.3	-	1	124	c.52G>C	c.(52-54)Gag>Cag	p.E18Q	EBF3_ENST00000355311.5_Missense_Mutation_p.E18Q	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	18					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CCCAGCGGCTCCTCCTTCATG	0.677000													13	52					0	0	1	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659809	24659809	+	RNA	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr22:24659809G>A	ENST00000414583.2	+	0	3334					NR_003714.1																						CCCTATCTGCGCACCCGGAGG	0.612000													2	1					0	0	1	0	0
MTMR4	9110	broad.mit.edu	37	17	56573018	56573018	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr17:56573018T>A	ENST00000323456.5	-	16	2609	c.2485A>T	c.(2485-2487)Agc>Tgc	p.S829C	MTMR4_ENST00000579925.1_Missense_Mutation_p.S772C	NM_004687.4	NP_004678.3	Q9NYA4	MTMR4_HUMAN	myotubularin related protein 4	829						cytoplasm|membrane	metal ion binding|protein tyrosine phosphatase activity			breast(10)|endometrium(2)|kidney(2)|large_intestine(5)|lung(12)|skin(5)	36	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AAGTCAGTGCTTGGGTCTAGA	0.552000													21	63					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125083798	125083798	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr8:125083798G>T	ENST00000522917.1	+	31	4224	c.4018G>T	c.(4018-4020)Ggg>Tgg	p.G1340W	FER1L6_ENST00000399018.1_Missense_Mutation_p.G1340W|FER1L6-AS2_ENST00000520031.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1340						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TGAGGACAGCGGGCAGCTGAG	0.517000													3	81					1	1	1	1	0
ASXL3	80816	broad.mit.edu	37	18	31325236	31325236	+	Silent	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr18:31325236G>A	ENST00000269197.5	+	12	5424	c.5424G>A	c.(5422-5424)aaG>aaA	p.K1808K		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1808					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						CAGATGGTAAGGGCTACTTGG	0.483000													28	140					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97981407	97981407	+	Missense_Mutation	SNP	C	C	T	rs142619737	byFrequency	TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:97981407C>T	ENST00000370192.3	-	13	1715	c.1615G>A	c.(1615-1617)Gga>Aga	p.G539R		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	539					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity	p.G539R(2)		NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AACTTCAATCCGGCCATTTCT	0.448000													8	35					0	0	1	0	0
ANKFN1	162282	broad.mit.edu	37	17	54305291	54305291	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr17:54305291A>G	ENST00000566473.2	+	2	35	c.35A>G	c.(34-36)aAa>aGa	p.K12R	ANKFN1_ENST00000574292.1_3'UTR|ANKFN1_ENST00000318698.2_Missense_Mutation_p.K12R			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	12										NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						CTACTCTTTAAAGACAGGCAT	0.338000													6	19					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95522727	95522727	+	RNA	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:95522727C>A	ENST00000432432.2	-	0	300					NR_040113.1													p.R64L(2)									CTGCTTGTCCCGGGCGTCCAG	0.731000													3	33					0.184627	0.189902	1	1	0
DZIP3	9666	broad.mit.edu	37	3	108363265	108363265	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr3:108363265G>C	ENST00000361582.3	+	14	1626	c.1396G>C	c.(1396-1398)Gac>Cac	p.D466H	DZIP3_ENST00000463306.1_Missense_Mutation_p.D466H	NM_014648.3	NP_055463.1	Q86Y13	DZIP3_HUMAN	DAZ interacting zinc finger protein 3	466					protein polyubiquitination	cytoplasm	polyubiquitin binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(21)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	45						CAAACAGTTTGACTTATGCCT	0.418000													27	57					0	0	1	0	0
TDRD7	23424	broad.mit.edu	37	9	100227242	100227242	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr9:100227242G>T	ENST00000355295.4	+	8	1856	c.1561G>T	c.(1561-1563)Gcc>Tcc	p.A521S	TDRD7_ENST00000422139.2_Missense_Mutation_p.A447S	NM_014290.2	NP_055105.2	Q8NHU6	TDRD7_HUMAN	tudor domain containing 7	521	Tudor 1.				lens fiber cell differentiation|lens morphogenesis in camera-type eye|posttranscriptional regulation of gene expression|spermatogenesis	chromatoid body	mRNA binding			endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29		Acute lymphoblastic leukemia(62;0.158)				GCAGTTGCTGGCCGTAAATGC	0.448000													9	26					2.17888e-05	2.54202e-05	1	1	0
SPIC	121599	broad.mit.edu	37	12	101880376	101880376	+	Nonsense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr12:101880376C>T	ENST00000551346.1	+	6	733	c.574C>T	c.(574-576)Cag>Tag	p.Q192*	SPIC_ENST00000299272.5_Nonsense_Mutation_p.Q192*			Q8N5J4	SPIC_HUMAN	Spi-C transcription factor (Spi-1/PU.1 related)	192						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	22						GCTGACTTACCAGTTCAGTGA	0.453000													12	75					0	0	1	0	0
PGA3	643834	broad.mit.edu	37	11	60971000	60971000	+	Translation_Start_Site	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr11:60971000C>A	ENST00000325558.6	+	0	149					NM_001079807.1	NP_001073275.1			pepsinogen 3, group I (pepsinogen A)											endometrium(1)|lung(1)|ovary(1)|skin(2)	5						TTCCTCCCGTCTTGCCTTCTC	0.572000													12	160					2.32078e-09	3.06198e-09	1	1	0
VIT	5212	broad.mit.edu	37	2	37035872	37035872	+	Silent	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:37035872C>A	ENST00000379242.3	+	15	1949	c.1647C>A	c.(1645-1647)atC>atA	p.I549I	VIT_ENST00000401530.1_Silent_p.I513I|VIT_ENST00000497382.1_Silent_p.I203I|VIT_ENST00000389975.3_Silent_p.I534I|VIT_ENST00000404084.1_Silent_p.I486I|VIT_ENST00000379241.3_Silent_p.I512I	NM_053276.3	NP_444506.2	Q6UXI7	VITRN_HUMAN	vitrin	534	VWFA 2.					proteinaceous extracellular matrix				autonomic_ganglia(1)|breast(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_hematologic(82;0.248)				ACACGCGCATCGGGGCCGTGC	0.582000													10	81					0.010729	0.011654	1	1	0
FGF13	2258	broad.mit.edu	37	X	137717721	137717721	+	Silent	SNP	G	G	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chrX:137717721G>C	ENST00000315930.6	-	4	1159	c.498C>G	c.(496-498)ggC>ggG	p.G166G	FGF13_ENST00000441825.2_Silent_p.G147G|FGF13_ENST00000541469.1_Silent_p.G120G|FGF13_ENST00000370603.3_Silent_p.G176G|FGF13_ENST00000305414.4_Silent_p.G113G	NM_004114.3	NP_004105.1	Q92913	FGF13_HUMAN	fibroblast growth factor 13	166					cell-cell signaling|MAPKKK cascade|nervous system development	cytoplasm|nucleus	growth factor activity|protein kinase activator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)	24	Acute lymphoblastic leukemia(192;0.000127)					ACCACCCTCGGCCTGACTGCT	0.423000													17	99					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22942333	22942333	+	Silent	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr19:22942333G>A	ENST00000397104.3	-	4	440	c.441C>T	c.(439-441)caC>caT	p.H147H	ZNF99_ENST00000596209.1_Silent_p.H126H					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				AAGCTTCTTCGTGCATCTTAC	0.299000													6	46					0	0	1	0	0
KIAA1244	57221	broad.mit.edu	37	6	138607928	138607928	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr6:138607928G>A	ENST00000251691.4	+	16	2826	c.2660G>A	c.(2659-2661)aGc>aAc	p.S887N		NM_020340.4	NP_065073.3	Q5TH69	BIG3_HUMAN	KIAA1244	887					regulation of ARF protein signal transduction	cytoplasm|integral to membrane	ARF guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(11)|lung(17)|ovary(2)|skin(2)	44	Breast(32;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00102)|GBM - Glioblastoma multiforme(68;0.00259)		ATGGCGGGGAGCTCCAAAGGG	0.557000													18	119					0	0	1	0	0
MRPS9	64965	broad.mit.edu	37	2	105654581	105654581	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:105654581G>A	ENST00000258455.3	+	1	141	c.31G>A	c.(31-33)Gca>Aca	p.A11T	AC010884.1_ENST00000456519.1_RNA	NM_182640.2	NP_872578.1	P82933	RT09_HUMAN	mitochondrial ribosomal protein S9	11					DNA damage response, detection of DNA damage|translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	18						CTACGGCGGAGCAGTTTCGTA	0.642000													4	25					0	0	1	0	0
ANO2	57101	broad.mit.edu	37	12	5941669	5941669	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr12:5941669T>A	ENST00000327087.8	-	5	793	c.722A>T	c.(721-723)aAc>aTc	p.N241I	ANO2_ENST00000546188.1_Missense_Mutation_p.N242I|ANO2_ENST00000356134.5_Missense_Mutation_p.N242I			Q9NQ90	ANO2_HUMAN	anoctamin 2	246						chloride channel complex|plasma membrane	intracellular calcium activated chloride channel activity			central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(1)	58						CATCTTGTTGTTGCTGTGTTC	0.517000													15	54					0	0	1	0	0
ZNF195	7748	broad.mit.edu	37	11	3380510	3380510	+	Silent	SNP	T	T	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr11:3380510T>C	ENST00000354599.6	-	4	1616	c.1512A>G	c.(1510-1512)aaA>aaG	p.K504K	ZNF195_ENST00000005082.9_Silent_p.K553K|ZNF195_ENST00000528796.1_Intron|ZNF195_ENST00000399602.4_Silent_p.K576K|ZNF195_ENST00000343338.7_Silent_p.K508K|ZNF195_ENST00000429541.2_Silent_p.K508K|ZNF195_ENST00000526601.1_Silent_p.K557K	NM_001242843.1|NM_001256825.1|NM_007152.4	NP_001229772.1|NP_001243754.1|NP_009083.2	O14628	ZN195_HUMAN	zinc finger protein 195	576					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)	17		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		ATTTGTAGGGTTTCTCTCCAG	0.393000													3	50					0	0	1	0	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77509891	77509891	+	Silent	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:77509891C>A	ENST00000477717.1	+	3	499	c.264C>A	c.(262-264)ccC>ccA	p.P88P		NM_030965.1	NP_112227.1	Q9BVH7	SIA7E_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	88					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	18						CCTTCCAGCCCCTGAAAATGC	0.592000													5	37					0.00116845	0.00129713	1	1	0
ADAMTS18	170692	broad.mit.edu	37	16	77401531	77401531	+	Silent	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr16:77401531C>A	ENST00000282849.5	-	4	1003	c.585G>T	c.(583-585)gcG>gcT	p.A195A	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	195					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						GATGGTGACCCGCAGGGGAGC	0.517000													23	64					1.12875e-08	1.4587e-08	1	1	0
TMEM125	128218	broad.mit.edu	37	1	43738640	43738640	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:43738640G>T	ENST00000432792.2	+	4	817	c.247G>T	c.(247-249)Gtg>Ttg	p.V83L	TMEM125_ENST00000439858.1_Missense_Mutation_p.V83L			Q96AQ2	TM125_HUMAN	transmembrane protein 125	83						integral to membrane				breast(1)|large_intestine(1)|lung(1)	3	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GCTGGTTCTGGTGAAACAGCT	0.652000													5	34					0.184627	0.189902	1	1	0
ZBED1	9189	broad.mit.edu	37	X	2408325	2408325	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chrX:2408325C>T	ENST00000381223.4	-	2	639	c.436G>A	c.(436-438)Gag>Aag	p.E146K	ZBED1_ENST00000381218.3_Missense_Mutation_p.E146K|ZBED1_ENST00000381222.2_Missense_Mutation_p.E146K|DHRSX_ENST00000334651.5_Intron	NM_001171135.1|NM_001171136.1|NM_004729.3	NP_001164606.1|NP_001164607.1|NP_004720.1	O96006	ZBED1_HUMAN	zinc finger, BED-type containing 1	146						nuclear chromosome	DNA binding|metal ion binding|protein dimerization activity|transposase activity			endometrium(8)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	25		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AAGGTGGGCTCGTCCACGATG	0.652000													10	98					0	0	1	0	0
RFTN2	130132	broad.mit.edu	37	2	198436779	198436779	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:198436779C>G	ENST00000295049.3	-	9	1995	c.1459G>C	c.(1459-1461)Gga>Cga	p.G487R		NM_144629.2	NP_653230.2	Q52LD8	RFTN2_HUMAN	raftlin family member 2	487						plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(6)|lung(13)|urinary_tract(3)	30						TCAAACTGTCCGTCGTCTAAT	0.507000													4	65					0	0	1	0	0
ERN1	2081	broad.mit.edu	37	17	62144144	62144144	+	Silent	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr17:62144144G>A	ENST00000433197.2	-	8	824	c.729C>T	c.(727-729)atC>atT	p.I243I		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	243					activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						CAGCGACATTGATGTGCATCA	0.572000													4	36					0	0	1	0	0
SKI	6497	broad.mit.edu	37	1	2237607	2237607	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:2237607G>T	ENST00000378536.4	+	6	1988	c.1916G>T	c.(1915-1917)cGg>cTg	p.R639L		NM_003036.3	NP_003027.1	P12755	SKI_HUMAN	v-ski avian sarcoma viral oncogene homolog	639					anterior/posterior axis specification|BMP signaling pathway|bone morphogenesis|cell motility|cell proliferation|embryonic limb morphogenesis|face morphogenesis|lens morphogenesis in camera-type eye|myelination in peripheral nervous system|myotube differentiation|negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of fibroblast proliferation|negative regulation of osteoblast differentiation|negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|neural tube closure|nose morphogenesis|olfactory bulb development|palate development|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|protein homotrimerization|regulation of apoptosis|retina development in camera-type eye|skeletal muscle fiber development|SMAD protein signal transduction|somatic stem cell maintenance|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|PML body|transcription factor complex|transcriptional repressor complex	histone deacetylase inhibitor activity|nucleotide binding|protein domain specific binding|protein kinase binding|repressing transcription factor binding|SMAD binding|transcription corepressor activity|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(1)|kidney(2)|lung(5)|prostate(1)|stomach(1)	10	all_cancers(77;0.000139)|all_epithelial(69;4.45e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)			Epithelial(90;2.14e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.72e-29)|GBM - Glioblastoma multiforme(42;2.45e-08)|Colorectal(212;5.33e-05)|COAD - Colon adenocarcinoma(227;0.000228)|Kidney(185;0.00268)|BRCA - Breast invasive adenocarcinoma(365;0.00471)|STAD - Stomach adenocarcinoma(132;0.0147)|KIRC - Kidney renal clear cell carcinoma(229;0.0385)|Lung(427;0.207)		CGCCTGAAGCGGGAGCTGGAG	0.682000													3	7					0.000602214	0.000683595	1	1	0
PCDH11X	27328	broad.mit.edu	37	X	91133690	91133690	+	Silent	SNP	T	T	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chrX:91133690T>A	ENST00000373094.1	+	2	3296	c.2451T>A	c.(2449-2451)gcT>gcA	p.A817A	PCDH11X_ENST00000361655.2_Silent_p.A817A|PCDH11X_ENST00000406881.1_Silent_p.A817A|PCDH11X_ENST00000373088.1_Silent_p.A817A|PCDH11X_ENST00000361724.1_Silent_p.A817A|PCDH11X_ENST00000504220.1_Silent_p.A817A|PCDH11X_ENST00000373097.1_Silent_p.A817A|PCDH11X_ENST00000395337.2_Silent_p.A817A|PCDH11X_ENST00000298274.8_Silent_p.A817A	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	817					homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						TGGTTGCAGCTGTTGCTGGCA	0.468000													4	59					0	0	1	0	0
TOP2A	7153	broad.mit.edu	37	17	38569028	38569028	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr17:38569028T>A	ENST00000423485.1	-	7	930	c.772A>T	c.(772-774)Aat>Tat	p.N258Y		NM_001067.3	NP_001058.2	P11388	TOP2A_HUMAN	topoisomerase (DNA) II alpha 170kDa	258					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(9)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	39		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	TTATTTCCATTAAGAAAGACT	0.348000													5	18					0	0	1	0	0
STON1	11037	broad.mit.edu	37	2	48808711	48808711	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:48808711G>T	ENST00000309835.3	+	1	949	c.939G>T	c.(937-939)caG>caT	p.Q313H	STON1_ENST00000406226.1_Missense_Mutation_p.Q313H|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.Q313H|STON1_ENST00000404752.1_Missense_Mutation_p.Q313H|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.Q313H|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.Q313H|STON1-GTF2A1L_ENST00000394754.1_Missense_Mutation_p.Q313H|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.Q313H					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ATTATGAACAGGGATTAGAAA	0.393000													12	103					4.3838e-07	5.4689e-07	1	1	0
ABL1	25	broad.mit.edu	37	9	133747590	133747590	+	Silent	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr9:133747590G>A	ENST00000318560.5	+	5	1278	c.897G>A	c.(895-897)gtG>gtA	p.V299V		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	299	Protein kinase.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	CTAACCTGGTGCAGCTCCTTG	0.577000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								8	14					0	0	1	0	0
EFCAB1	79645	broad.mit.edu	37	8	49643135	49643135	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr8:49643135G>T	ENST00000433756.1	-	2	286	c.127C>A	c.(127-129)Ctg>Atg	p.L43M	EFCAB1_ENST00000523092.1_Missense_Mutation_p.L43M|EFCAB1_ENST00000521002.1_Intron|EFCAB1_ENST00000262103.3_Missense_Mutation_p.L95M	NM_001142857.1	NP_001136329.1	Q9HAE3	EFCB1_HUMAN	EF-hand calcium binding domain 1	95							calcium ion binding			endometrium(1)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|urinary_tract(2)	14		all_epithelial(80;0.0134)|Lung NSC(129;0.0207)|all_lung(136;0.0464)				CGAAGAAACAGTGATAATCCA	0.348000													7	28					1.12685e-05	1.33946e-05	1	1	0
ABCD2	225	broad.mit.edu	37	12	40012582	40012582	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr12:40012582C>A	ENST00000308666.3	-	1	971	c.836G>T	c.(835-837)gGc>gTc	p.G279V		NM_005164.3	NP_005155.1	Q9UBJ2	ABCD2_HUMAN	ATP-binding cassette, sub-family D (ALD), member 2	279	ABC transmembrane type-1.				fatty acid metabolic process|transport	ATP-binding cassette (ABC) transporter complex|integral to plasma membrane|peroxisomal membrane	ATP binding|ATPase activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(24)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	52						CACCAGTTTGCCAAATTTGGG	0.463000													26	79					7.41945e-09	9.63764e-09	1	1	0
IGF2BP1	10642	broad.mit.edu	37	17	47117345	47117345	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr17:47117345C>T	ENST00000290341.3	+	7	1044	c.710C>T	c.(709-711)gCa>gTa	p.A237V	IGF2BP1_ENST00000431824.2_Intron	NM_006546.3	NP_006537.3	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding protein 1	237	KH 1.|Necessary for interaction with ELAVL4 and binding to TAU mRNA (By similarity).				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						AAGGAGAACGCAGGTGCAGCT	0.542000													29	98					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	118199146	118199146	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr12:118199146G>A	ENST00000425217.1	-	4	623	c.569C>T	c.(568-570)cCt>cTt	p.P190L	KSR2_ENST00000339824.5_Missense_Mutation_p.P219L	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	219	Pro-rich.				intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGTGTACACAGGGGCCCCGGG	0.701000													7	27					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150948474	150948474	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr5:150948474C>A	ENST00000261800.5	-	1	31	c.19G>T	c.(19-21)Ggt>Tgt	p.G7C		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	7					epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATGGCAAAACCCAGCAGGGCA	0.483000													7	70					0.000157383	0.000181099	1	1	0
FOXN2	3344	broad.mit.edu	37	2	48600429	48600429	+	Splice_Site	SNP	A	A	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:48600429A>C	ENST00000340553.3	+	6	964		c.e6-1			NM_002158.3	NP_002149.2	P32314	FOXN2_HUMAN	forkhead box N2						embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	13		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.0272)|LUSC - Lung squamous cell carcinoma(58;0.036)			TTCCCTTTTCAGAATCTGATA	0.303000													14	41					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577046	7577046	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr17:7577046C>A	ENST00000420246.2	-	8	1024	c.892G>T	c.(892-894)Gag>Tag	p.E298*	TP53_ENST00000455263.2_Nonsense_Mutation_p.E298*|TP53_ENST00000269305.4_Nonsense_Mutation_p.E298*|TP53_ENST00000445888.2_Nonsense_Mutation_p.E298*|TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Nonsense_Mutation_p.E298*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	298	Interaction with HIPK1 (By similarity).		E -> A (in a sporadic cancer; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E298*(49)|p.0?(8)|p.?(2)|p.E298K(1)|p.L299fs*2(1)|p.L265_K305del41(1)|p.E298fs*53(1)|p.G293fs*1(1)|p.E298Q(1)|p.E298_P301delELPP(1)|p.H296_S303delHHELPPGS(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGGGCAGCTCGTGGTGAGGC	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			22	58					9.65021e-13	1.37393e-12	1	1	0
RPS27A	6233	broad.mit.edu	37	2	55462635	55462635	+	Silent	SNP	T	T	C	rs137921682	by1000genomes	TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:55462635T>C	ENST00000272317.6	+	6	717	c.393T>C	c.(391-393)ttT>ttC	p.F131F	RPS27A_ENST00000404735.1_Silent_p.F131F|RPS27A_ENST00000402285.3_Silent_p.F131F	NM_002954.5	NP_002945.1	P62979	RS27A_HUMAN	ribosomal protein S27a	131					activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endocrine pancreas development|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	metal ion binding|structural constituent of ribosome			cervix(1)|ovary(1)|urinary_tract(1)	3						CTGGGGTGTTTATGGCAAGTC	0.408000													26	131					0	0	1	0	0
NOTCH1	4851	broad.mit.edu	37	9	139396253	139396253	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr9:139396253G>A	ENST00000277541.6	-	30	5660	c.5585C>T	c.(5584-5586)cCg>cTg	p.P1862L		NM_017617.3	NP_060087.3	P46531	NOTC1_HUMAN	notch 1	1862					aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			breast(16)|central_nervous_system(17)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1183)|kidney(4)|large_intestine(1)|lung(57)|oesophagus(2)|ovary(3)|pancreas(1)|prostate(3)|skin(21)|upper_aerodigestive_tract(39)|urinary_tract(3)	1359	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		ACCCTGGGGCGGTGTGGGGGC	0.672000			"""T, Mis, O"""	TRB@	T-ALL					HNSCC(8;0.001)			3	33					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55873213	55873213	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr11:55873213C>A	ENST00000313503.1	+	1	695	c.695C>A	c.(694-696)tCa>tAa	p.S232*		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					AATTCCACTTCAGGAAAGCAG	0.368000										HNSCC(53;0.14)			9	57					5.4927e-09	7.17182e-09	1	1	0
TSC2	7249	broad.mit.edu	37	16	2129276	2129276	+	Splice_Site	SNP	G	G	C	rs45443096		TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr16:2129276G>C	ENST00000219476.3	+	28	3761		c.e28-1		TSC2_ENST00000353929.4_Splice_Site|TSC2_ENST00000568366.1_Splice_Site|TSC2_ENST00000401874.2_Splice_Site|TSC2_ENST00000439673.2_Splice_Site|TSC2_ENST00000350773.4_Splice_Site|TSC2_ENST00000382538.6_Splice_Site|TSC2_ENST00000568454.1_Splice_Site	NM_000548.3	NP_000539.2	P49815	TSC2_HUMAN	tuberous sclerosis 2						cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				CTGTCTTCTAGGTCTCCTGTG	0.637000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				20	59					0	0	1	0	0
SLC6A15	55117	broad.mit.edu	37	12	85264442	85264442	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr12:85264442T>A	ENST00000266682.5	-	9	1851	c.1310A>T	c.(1309-1311)cAg>cTg	p.Q437L	SLC6A15_ENST00000552192.1_Missense_Mutation_p.Q330L|SLC6A15_ENST00000309283.7_Missense_Mutation_p.Q145L	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	437					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						GCCGGTCCCCTGAACAGCCTG	0.398000													16	55					0	0	1	0	0
ATF6	22926	broad.mit.edu	37	1	161761933	161761933	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:161761933G>T	ENST00000367942.3	+	6	571	c.504G>T	c.(502-504)aaG>aaT	p.K168N		NM_007348.3	NP_031374.2	P18850	ATF6A_HUMAN	activating transcription factor 6	168					positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(14)|ovary(3)|skin(1)|stomach(1)	34	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			TGACTCCAAAGAAAAAAATTC	0.398000													16	123					8.00594e-06	9.5616e-06	1	1	0
NCBP2L	392517	broad.mit.edu	37	X	107037827	107037827	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chrX:107037827G>A	ENST00000372379.1	+	1	377	c.377G>A	c.(376-378)gGt>gAt	p.G126D						nuclear cap binding protein subunit 2-like											large_intestine(1)|lung(2)|skin(1)|urinary_tract(1)	5						TATGGTCGCGGTAAATCTGGG	0.458000													3	50					0	0	1	0	0
KIAA1522	57648	broad.mit.edu	37	1	33234331	33234331	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:33234331G>A	ENST00000401073.2	+	4	611	c.541G>A	c.(541-543)Gca>Aca	p.A181T	KIAA1522_ENST00000373480.1_Missense_Mutation_p.A122T|KIAA1522_ENST00000294521.3_Missense_Mutation_p.A122T|KIAA1522_ENST00000373481.3_Missense_Mutation_p.A133T	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	122										breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				GAGCTCCACAGCAGAGGACGC	0.592000													5	50					0	0	1	0	0
QSOX1	5768	broad.mit.edu	37	1	180158767	180158767	+	Silent	SNP	T	T	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:180158767T>C	ENST00000367602.3	+	9	1172	c.1098T>C	c.(1096-1098)atT>atC	p.I366I	QSOX1_ENST00000367600.5_Silent_p.I366I			O00391	QSOX1_HUMAN	quiescin Q6 sulfhydryl oxidase 1	366					cell redox homeostasis|protein thiol-disulfide exchange	extracellular space|integral to Golgi membrane	flavin-linked sulfhydryl oxidase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						GAAATAAAATTCCCTACAGTT	0.483000													18	90					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123599887	123599887	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr7:123599887T>C	ENST00000340011.5	+	5	1751	c.1394T>C	c.(1393-1395)aTa>aCa	p.I465T	SPAM1_ENST00000402183.2_Missense_Mutation_p.I465T|SPAM1_ENST00000439500.1_Missense_Mutation_p.I465T|SPAM1_ENST00000223028.7_Missense_Mutation_p.I465T|SPAM1_ENST00000460182.1_Missense_Mutation_p.I465T	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	465					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	GGTGTCTGTATAGATGCTTTT	0.383000													16	58					0	0	1	0	0
ZNF528	84436	broad.mit.edu	37	19	52918874	52918874	+	Missense_Mutation	SNP	T	T	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr19:52918874T>G	ENST00000360465.3	+	7	1195	c.769T>G	c.(769-771)Tca>Gca	p.S257A	ZNF528_ENST00000391788.2_3'UTR	NM_032423.2	NP_115799.2	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	257					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(6)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	39				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		TTCAAACCTTTCACAACATCA	0.388000													3	53					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38951109	38951109	+	Silent	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr19:38951109C>A	ENST00000355481.4	+	20	2586	c.2455C>A	c.(2455-2457)Cga>Aga	p.R819R	RYR1_ENST00000360985.3_Silent_p.R819R|RYR1_ENST00000359596.3_Silent_p.R819R	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	819					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CCCTCGAGAGCGACTCCATCT	0.642000													29	132					2.19358e-23	3.41223e-23	1	1	0
POLRMT	5442	broad.mit.edu	37	19	625205	625205	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr19:625205C>A	ENST00000588649.2	-	4	956	c.872G>T	c.(871-873)gGc>gTc	p.G291V		NM_005035.3	NP_005026.3	O00411	RPOM_HUMAN	polymerase (RNA) mitochondrial (DNA directed)	291					transcription initiation from mitochondrial promoter	mitochondrial nucleoid	DNA binding|DNA-directed RNA polymerase activity|protein binding			cervix(2)|endometrium(3)|large_intestine(1)|lung(9)|ovary(1)|pancreas(2)|prostate(1)|stomach(1)	20		all_epithelial(18;2.78e-22)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;3.55e-06)|all_lung(49;5.41e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGAGTCAAGCCGGCATCCTT	0.622000													37	95					1.04594e-18	1.59743e-18	1	1	0
PCDH11X	27328	broad.mit.edu	37	X	91132951	91132951	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chrX:91132951C>A	ENST00000373094.1	+	2	2557	c.1712C>A	c.(1711-1713)aCt>aAt	p.T571N	PCDH11X_ENST00000361655.2_Missense_Mutation_p.T571N|PCDH11X_ENST00000406881.1_Missense_Mutation_p.T571N|PCDH11X_ENST00000373088.1_Missense_Mutation_p.T571N|PCDH11X_ENST00000361724.1_Missense_Mutation_p.T571N|PCDH11X_ENST00000504220.1_Missense_Mutation_p.T571N|PCDH11X_ENST00000373097.1_Missense_Mutation_p.T571N|PCDH11X_ENST00000395337.2_Missense_Mutation_p.T571N|PCDH11X_ENST00000298274.8_Missense_Mutation_p.T571N	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	571	Cadherin 6.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CCAGTTTTCACTCACAATGAA	0.403000													11	62					2.80697e-09	3.68415e-09	1	1	0
ADAMTSL3	57188	broad.mit.edu	37	15	84611511	84611511	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr15:84611511C>A	ENST00000286744.5	+	18	2505	c.2281C>A	c.(2281-2283)Cct>Act	p.P761T	ADAMTSL3_ENST00000567476.1_Missense_Mutation_p.P761T	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	761						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			TGACTGCCCTCCTGGCTGGCA	0.567000													4	19					0.150653	0.156879	1	1	0
AMPD2	271	broad.mit.edu	37	1	110163670	110163670	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:110163670G>A	ENST00000256578.3	+	1	395	c.35G>A	c.(34-36)cGg>cAg	p.R12Q	AMPD2_ENST00000528667.1_Missense_Mutation_p.R12Q|AMPD2_ENST00000526301.1_Intron|AMPD2_ENST00000342115.4_Intron	NM_004037.7	NP_004028.3	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2	12					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			breast(1)|large_intestine(3)|ovary(2)|skin(1)	7		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		TTCCGCCTGCGGAGCCGCTGC	0.672000													15	46					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55863620	55863620	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr7:55863620G>A	ENST00000388975.3	-	10	1401	c.1285C>T	c.(1285-1287)Cat>Tat	p.H429Y		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	429					cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TTCTTACGATGTTTGTCTTTC	0.373000													10	56					0	0	1	0	0
DENND5B	160518	broad.mit.edu	37	12	31540647	31540647	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr12:31540647C>A	ENST00000389082.5	-	21	3979	c.3715G>T	c.(3715-3717)Gct>Tct	p.A1239S	DENND5B_ENST00000536562.1_Missense_Mutation_p.A1274S|DENND5B_ENST00000306833.6_Missense_Mutation_p.A1274S	NM_144973.3	NP_659410.3	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	1239	RUN 2.					integral to membrane				NS(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(8)|lung(17)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						CGCAGGAGAGCGCTCTCTTCA	0.493000													7	40					0.0293803	0.0311086	1	1	0
ZNF25	219749	broad.mit.edu	37	10	38245973	38245973	+	Silent	SNP	T	T	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr10:38245973T>C	ENST00000302609.7	-	4	425	c.213A>G	c.(211-213)gtA>gtG	p.V71V	ZNF25_ENST00000374633.1_5'UTR	NM_145011.2	NP_659448.1	P17030	ZNF25_HUMAN	zinc finger protein 25	71	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(11)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_neural(218;0.0218)|Breast(68;0.0389)|Ovarian(717;0.0443)|Renal(717;0.157)				GTGGAAATTCTACTTCTAATA	0.403000													4	41					0	0	1	0	0
IQGAP3	128239	broad.mit.edu	37	1	156508667	156508667	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:156508667T>A	ENST00000361170.2	-	26	3225	c.3215A>T	c.(3214-3216)cAc>cTc	p.H1072L	IQGAP3_ENST00000498755.1_5'UTR	NM_178229.4	NP_839943.2	Q86VI3	IQGA3_HUMAN	IQ motif containing GTPase activating protein 3	1072	Ras-GAP.				small GTPase mediated signal transduction	intracellular	calmodulin binding|Ras GTPase activator activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(14)|lung(29)|ovary(5)|prostate(5)|skin(5)|urinary_tract(3)	75	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					AGGGTCTGTGTGGACGCTGAG	0.562000													19	33					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70928281	70928281	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr12:70928281C>T	ENST00000334414.6	-	31	6399	c.6355G>A	c.(6355-6357)Gtg>Atg	p.V2119M	RP11-588H23.3_ENST00000547656.1_RNA|PTPRB_ENST00000451516.2_Missense_Mutation_p.V1811M|RP11-588H23.3_ENST00000549460.1_RNA|PTPRB_ENST00000550857.1_Missense_Mutation_p.V1811M|PTPRB_ENST00000550358.1_Missense_Mutation_p.V2031M|PTPRB_ENST00000261266.5_Missense_Mutation_p.V1901M|RP11-588H23.3_ENST00000548687.1_RNA|PTPRB_ENST00000538708.1_Missense_Mutation_p.V1811M|RP11-588H23.3_ENST00000546836.1_RNA|RP11-588H23.3_ENST00000551438.1_RNA	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1901					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CAGTGCACCACAGTGGGCCCA	0.527000													4	23					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198711391	198711391	+	Silent	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:198711391C>A	ENST00000367376.2	+	25	2757	c.2586C>A	c.(2584-2586)atC>atA	p.I862I	PTPRC_ENST00000348564.6_Silent_p.I703I|PTPRC_ENST00000352140.3_Silent_p.I814I|PTPRC_ENST00000442510.2_Silent_p.I864I|PTPRC_ENST00000594404.1_Silent_p.I701I	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	862	Tyrosine-protein phosphatase 1.				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						GAACCTATATCGGAATTGATG	0.468000													21	87					1.17739e-12	1.66687e-12	1	1	0
LRRC16A	55604	broad.mit.edu	37	6	25538152	25538152	+	Missense_Mutation	SNP	A	A	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr6:25538152A>C	ENST00000329474.6	+	25	2505	c.2137A>C	c.(2137-2139)Atc>Ctc	p.I713L		NM_001173977.1|NM_017640.5	NP_001167448.1|NP_060110.4	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	713					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				breast(4)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	50						GGGAGACGCTATCCAGGAAGA	0.428000													3	9					0	0	1	0	0
TNFSF13	8741	broad.mit.edu	37	17	7463672	7463672	+	Silent	SNP	G	G	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr17:7463672G>C	ENST00000349228.4	+	4	1026	c.462G>C	c.(460-462)ctG>ctC	p.L154L	TNFSF13_ENST00000483039.1_Silent_p.L34L|TNFSF13_ENST00000338784.4_Silent_p.L170L|TNFSF13_ENST00000396545.4_Silent_p.L170L|TNFSF12-TNFSF13_ENST00000293826.4_Silent_p.L250L|TNFSF13_ENST00000380535.4_Silent_p.L142L|TNFSF12_ENST00000557233.1_Silent_p.L250L|TNFSF13_ENST00000396542.1_Silent_p.L125L	NM_172087.2	NP_742084.1			tumor necrosis factor (ligand) superfamily, member 13											large_intestine(2)|lung(2)|skin(1)	5		Prostate(122;0.157)				GCCAGGTCCTGTTTCAAGACG	0.542000											OREG0024138	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	57					0	0	1	0	0
KCNK3	3777	broad.mit.edu	37	2	26951259	26951259	+	Silent	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:26951259C>T	ENST00000302909.3	+	2	1133	c.1008C>T	c.(1006-1008)tcC>tcT	p.S336S		NM_002246.2	NP_002237.1	O14649	KCNK3_HUMAN	potassium channel, subfamily K, member 3	336					synaptic transmission	integral to plasma membrane				endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTCCACGTCCGACACGTGCG	0.682000													4	20					0	0	1	0	0
OR2M2	391194	broad.mit.edu	37	1	248344103	248344103	+	Silent	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:248344103G>A	ENST00000359682.2	+	1	816	c.816G>A	c.(814-816)aaG>aaA	p.K272K		NM_001004688.1	NP_001004688.1	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M, member 2	272					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(45)|ovary(3)|prostate(1)|skin(3)	70	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CGCAGGACAAGATGGTGTCTG	0.502000													36	174					0	0	1	0	0
CELF4	56853	broad.mit.edu	37	18	34855140	34855140	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr18:34855140A>G	ENST00000420428.2	-	4	910	c.515T>C	c.(514-516)tTc>tCc	p.F172S	CELF4_ENST00000591287.1_Missense_Mutation_p.F171S|CELF4_ENST00000588597.1_Missense_Mutation_p.F161S|CELF4_ENST00000591282.1_Missense_Mutation_p.F172S|CELF4_ENST00000361795.5_Missense_Mutation_p.F171S|RP11-797E24.3_ENST00000586610.1_RNA|RP11-797E24.3_ENST00000588766.1_RNA|CELF4_ENST00000334919.5_Missense_Mutation_p.F162S|CELF4_ENST00000412753.1_Missense_Mutation_p.F172S|CELF4_ENST00000603232.1_Missense_Mutation_p.F172S|CELF4_ENST00000601019.1_Missense_Mutation_p.F171S	NM_020180.3	NP_064565.1	Q9BZC1	CELF4_HUMAN	CUGBP, Elav-like family member 4	172	RRM 2.|Sufficient for RNA-binding and MSE- dependent splicing activity.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(18)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	44						AAAGGCCTCGAAAAGGCGGCG	0.617000													30	193					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136582447	136582447	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr6:136582447T>C	ENST00000531224.1	-	12	2965	c.2713A>G	c.(2713-2715)Atg>Gtg	p.M905V	BCLAF1_ENST00000527536.1_Missense_Mutation_p.M856V|BCLAF1_ENST00000529917.1_5'UTR|BCLAF1_ENST00000353331.4_Missense_Mutation_p.M854V|BCLAF1_ENST00000527759.1_Missense_Mutation_p.M903V|BCLAF1_ENST00000392348.2_Missense_Mutation_p.M854V|BCLAF1_ENST00000031135.9_Missense_Mutation_p.M123V|BCLAF1_ENST00000530767.1_Missense_Mutation_p.M732V	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	905					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TTATTTTCCATGGTCTCTTCT	0.383000													8	106					0	0	1	0	0
KEAP1	9817	broad.mit.edu	37	19	10599915	10599915	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr19:10599915C>T	ENST00000171111.5	-	5	2208	c.1661G>A	c.(1660-1662)cGa>cAa	p.R554Q	KEAP1_ENST00000393623.2_Missense_Mutation_p.R554Q	NM_203500.1	NP_987096.1	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	554					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(4)|liver(2)|lung(69)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	92			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			CAGGGCACTTCGCCGGTGCTT	0.602000													6	30					0	0	1	0	0
PEMT	10400	broad.mit.edu	37	17	17494897	17494897	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr17:17494897G>T	ENST00000395781.2	-	1	125	c.44C>A	c.(43-45)tCg>tAg	p.S15*	PEMT_ENST00000435340.2_Intron|PEMT_ENST00000255389.5_Nonsense_Mutation_p.S15*|RP11-524F11.2_ENST00000583662.1_RNA	NM_001267552.1	NP_001254481.1	Q9UBM1	PEMT_HUMAN	phosphatidylethanolamine N-methyltransferase	0					cell proliferation|phosphatidylcholine biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	phosphatidylethanolamine N-methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(2)|prostate(3)	7				Colorectal(2;0.0157)|READ - Rectum adenocarcinoma(2;0.0891)		CCCTGCCACCGAGCTGTTCGT	0.667000													5	22					0.217242	0.222541	1	1	0
SLC6A15	55117	broad.mit.edu	37	12	85279726	85279726	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr12:85279726G>T	ENST00000450363.3	-	3	869	c.411C>A	c.(409-411)agC>agA	p.S137R	SLC6A15_ENST00000552192.1_Missense_Mutation_p.S30R|SLC6A15_ENST00000551388.1_Intron|SLC6A15_ENST00000266682.5_Missense_Mutation_p.S137R	NM_018057.6	NP_060527.2	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	137					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						CCAGTTTAGGGCTTATGTAAT	0.368000													21	77					1.74197e-06	2.15185e-06	1	1	0
NDST3	9348	broad.mit.edu	37	4	119036052	119036052	+	Silent	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr4:119036052C>A	ENST00000296499.5	+	4	1564	c.1161C>A	c.(1159-1161)ccC>ccA	p.P387P	NDST3_ENST00000433996.2_Intron	NM_004784.2	NP_004775.1	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3	387	Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	54						ATATGCAGCCCCACCTCTTCC	0.448000													7	48					2.17888e-05	2.54202e-05	1	1	0
COL11A1	1301	broad.mit.edu	37	1	103440388	103440388	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:103440388G>T	ENST00000358392.2	-	36	3159	c.2842C>A	c.(2842-2844)Cct>Act	p.P948T	COL11A1_ENST00000512756.1_Missense_Mutation_p.P820T|COL11A1_ENST00000370096.3_Missense_Mutation_p.P936T|COL11A1_ENST00000353414.4_Missense_Mutation_p.P897T	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	936	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ACACTTACAGGAGGGCCTTTT	0.378000													5	20					2.0095e-06	2.45822e-06	1	1	0
KCNAB3	9196	broad.mit.edu	37	17	7830975	7830975	+	Splice_Site	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr17:7830975C>A	ENST00000303790.2	-	3	323	c.324_splice	c.e3+1	p.E108_splice	RP11-1099M24.7_ENST00000573621.1_3'UTR	NM_004732.3	NP_004723.2	O43448	KCAB3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 3	108						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)	8		Prostate(122;0.157)				TAACTTATACCTCATCTGAGA	0.502000													35	271					8.01111e-26	1.26175e-25	1	1	0
OR10Z1	128368	broad.mit.edu	37	1	158576274	158576274	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:158576274G>T	ENST00000361284.1	+	1	46	c.46G>T	c.(46-48)Ggc>Tgc	p.G16C		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					TGTCTTCCTGGGCTTCTCCAG	0.468000													15	59					2.32078e-09	3.06198e-09	1	1	0
ZNF479	90827	broad.mit.edu	37	7	57187572	57187572	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr7:57187572C>A	ENST00000331162.4	-	5	1820	c.1550G>T	c.(1549-1551)gGa>gTa	p.G517V		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	517					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			GGGTTTCTCTCCAGTGTGAAT	0.348000													5	22					0.0293803	0.0311086	1	1	0
PDGFRA	5156	broad.mit.edu	37	4	55155025	55155025	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr4:55155025G>T	ENST00000257290.5	+	20	3065	c.2734G>T	c.(2734-2736)Ggg>Tgg	p.G912W	FIP1L1_ENST00000507166.1_Missense_Mutation_p.G672W	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	912	Protein kinase.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	GATCAAGAGTGGGTACCGGAT	0.537000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			11	80					0.00316338	0.00349637	1	1	0
BHMT	635	broad.mit.edu	37	5	78415090	78415090	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr5:78415090C>G	ENST00000274353.5	+	3	282	c.175C>G	c.(175-177)Ctt>Gtt	p.L59V	BHMT_ENST00000524080.1_Intron|DMGDH_ENST00000520388.1_Intron	NM_001713.2	NP_001704.2	Q93088	BHMT1_HUMAN	betaine--homocysteine S-methyltransferase	59	Hcy-binding.				protein methylation|regulation of homocysteine metabolic process	cytoplasm	betaine-homocysteine S-methyltransferase activity|homocysteine S-methyltransferase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)	29		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;1.88e-45)|Epithelial(54;8.07e-41)|all cancers(79;3.51e-36)	L-Methionine(DB00134)	AGTTCGCCAGCTTCATCGAGA	0.438000													8	67					0	0	1	0	0
SNX14	57231	broad.mit.edu	37	6	86253019	86253019	+	Nonsense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr6:86253019C>A	ENST00000314673.3	-	14	1446	c.1270G>T	c.(1270-1272)Gaa>Taa	p.E424*	SNX14_ENST00000513865.1_Intron|SNX14_ENST00000508980.1_5'UTR|SNX14_ENST00000346348.3_Nonsense_Mutation_p.E380*|SNX14_ENST00000369627.2_Nonsense_Mutation_p.E424*|SNX14_ENST00000505648.1_Nonsense_Mutation_p.E372*	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14	424	RGS.				cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		TATGGGCCTTCAGCAACTATT	0.299000													11	26					3.07112e-06	3.68534e-06	1	1	0
TINAGL1	64129	broad.mit.edu	37	1	32052549	32052549	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:32052549G>T	ENST00000271064.7	+	12	1449	c.1373G>T	c.(1372-1374)cGc>cTc	p.R458L	TINAGL1_ENST00000457433.2_Missense_Mutation_p.R427L|TINAGL1_ENST00000481165.1_3'UTR	NM_001204415.1|NM_022164.2	NP_001191344.1|NP_071447.1	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	458					endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity			breast(2)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		GTCTGGGGCCGCGTGGGCATG	0.697000													8	10					3.07112e-06	3.68534e-06	1	1	0
ATF7	11016	broad.mit.edu	37	12	53931237	53931237	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr12:53931237G>C	ENST00000420353.2	-	5	513	c.364C>G	c.(364-366)Cct>Gct	p.P122A	ATF7_ENST00000328463.7_Missense_Mutation_p.P133A|ATF7_ENST00000548446.2_Missense_Mutation_p.P133A|RP11-793H13.10_ENST00000591834.1_Missense_Mutation_p.P122A|ATF7_ENST00000456903.4_Missense_Mutation_p.P122A|ATF7_ENST00000415113.1_Intron	NM_006856.2	NP_006847.1	P17544	ATF7_HUMAN	activating transcription factor 7	133	Transactivation domain.				interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)|urinary_tract(1)	9						CTAGAGGCAGGGCTATCAGGT	0.458000													15	66					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109155454	109155454	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr5:109155454G>A	ENST00000261483.4	+	14	3246	c.2194G>A	c.(2194-2196)Gat>Aat	p.D732N		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	732					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		ACATTTAGCTGATTATGTCTT	0.328000													6	77					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767868	77767868	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr8:77767868T>C	ENST00000521891.2	+	10	9159	c.8711T>C	c.(8710-8712)aTa>aCa	p.I2904T	ZFHX4_ENST00000455469.2_Missense_Mutation_p.I2859T|ZFHX4_ENST00000518282.1_Missense_Mutation_p.I2878T|ZFHX4_ENST00000050961.6_Missense_Mutation_p.I2859T	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2859						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACGTCCAGCATAGCGGACCCG	0.512000										HNSCC(33;0.089)			9	39					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238049083	238049083	+	Missense_Mutation	SNP	G	G	C	rs149320005		TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:238049083G>C	ENST00000366570.4	-	7	1101	c.943C>G	c.(943-945)Ctc>Gtc	p.L315V	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	315	ZP.				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			TCCAGAGTGAGGGGTCCAGGC	0.512000													7	55					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10466059	10466059	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr8:10466059C>T	ENST00000382483.3	-	4	5772	c.5549G>A	c.(5548-5550)gGt>gAt	p.G1850D		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1850					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GGCCTCTACACCTTCTGACTC	0.642000													6	285					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13615185	13615185	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr4:13615185C>A	ENST00000040738.5	-	5	1410	c.1275G>T	c.(1273-1275)gaG>gaT	p.E425D		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	425	Lys-rich.						DNA binding										TTACAACTTCCTCCTCAGTAT	0.383000													15	63					1.56452e-12	2.20257e-12	1	1	0
CADM1	23705	broad.mit.edu	37	11	115102140	115102140	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr11:115102140G>T	ENST00000542447.2	-	4	623	c.495C>A	c.(493-495)aaC>aaA	p.N165K	CADM1_ENST00000537058.1_Missense_Mutation_p.N165K|CADM1_ENST00000537140.1_5'UTR|CADM1_ENST00000452722.2_Missense_Mutation_p.N165K|CADM1_ENST00000536727.1_Missense_Mutation_p.N165K|CADM1_ENST00000331581.6_Missense_Mutation_p.N165K	NM_001098517.1	NP_001091987.1	Q9BY67	CADM1_HUMAN	cell adhesion molecule 1	165	Ig-like C2-type 1.				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		TAGCAGTGCAGTTGACTTCAA	0.453000													9	86					2.17888e-05	2.54202e-05	1	1	0
COL25A1	84570	broad.mit.edu	37	4	109805344	109805344	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr4:109805344G>A	ENST00000399132.1	-	19	1540	c.1010C>T	c.(1009-1011)cCg>cTg	p.P337L	COL25A1_ENST00000399126.1_Missense_Mutation_p.P337L|COL25A1_ENST00000399127.1_Missense_Mutation_p.P333L	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	337	Collagen-like 4.					collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CTTTATCCCCGGAAGTCCAGG	0.413000													4	30					0	0	1	0	0
CD1A	909	broad.mit.edu	37	1	158225836	158225836	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:158225836C>T	ENST00000289429.5	+	3	901	c.368C>T	c.(367-369)tCt>tTt	p.S123F		NM_001763.2	NP_001754.2	P06126	CD1A_HUMAN	CD1a molecule	123					antigen processing and presentation|immune response	endosome membrane|integral to plasma membrane|MHC class I protein complex				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	32	all_hematologic(112;0.0378)				Antithymocyte globulin(DB00098)	GAGCTGCACTCTGGAAAGGTC	0.423000													6	89					0	0	1	0	0
MEGF6	1953	broad.mit.edu	37	1	3511923	3511923	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:3511923C>T	ENST00000356575.4	-	3	581	c.355G>A	c.(355-357)Gac>Aac	p.D119N		NM_001409.3	NP_001400.3	O75095	MEGF6_HUMAN	multiple EGF-like-domains 6	119	EMI.					extracellular region	calcium ion binding			cervix(2)|endometrium(3)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		CCCTCCTCGTCGGGCTGCTGC	0.657000													4	68					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21416985	21416985	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr18:21416985A>G	ENST00000313654.9	+	25	3266	c.3025A>G	c.(3025-3027)Atc>Gtc	p.I1009V	LAMA3_ENST00000399516.3_Missense_Mutation_p.I1009V	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1009	Domain IV 1 (domain IV B).				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CATGAGCCGCATCGCCATGTA	0.483000													10	38					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398282	25398282	+	Missense_Mutation	SNP	C	C	A	rs121913535		TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr12:25398282C>A	ENST00000311936.3	-	2	228	c.37G>T	c.(37-39)Ggc>Tgc	p.G13C	KRAS_ENST00000556131.1_Missense_Mutation_p.G13C|KRAS_ENST00000557334.1_Missense_Mutation_p.G13C|KRAS_ENST00000256078.4_Missense_Mutation_p.G13C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	13			G -> D (in a breast carcinoma cell line and GASC; somatic mutation).|G -> R (in pylocytic astrocytoma; somatic mutation; increase activation of the Ras pathway).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G13C(213)|p.G13S(59)|p.G13R(43)|p.G12_G13insG(3)|p.G13N(1)|p.G13I(1)|p.G12_G13insA(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			TTGCCTACGCCACCAGCTCCA	0.343000	G13C(MORCPR_LUNG)|G13C(NCIH1355_LUNG)|G13C(NCIH1734_LUNG)|G13C(TOV21G_OVARY)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			3	23					1	1	1	1	0
ANKRD27	84079	broad.mit.edu	37	19	33134491	33134491	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr19:33134491C>T	ENST00000306065.4	-	6	730	c.572G>A	c.(571-573)aGg>aAg	p.R191K	ANKRD27_ENST00000587352.1_Missense_Mutation_p.R191K	NM_032139.2	NP_115515.2	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	191					early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			breast(3)|endometrium(7)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	42	Esophageal squamous(110;0.137)					GTGAGAGTCCCTCAGAAGCTG	0.542000													70	295					0	0	1	0	0
SPEF2	79925	broad.mit.edu	37	5	35779250	35779250	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr5:35779250C>A	ENST00000440995.2	+	30	4234	c.4234C>A	c.(4234-4236)Cac>Aac	p.H1412N	CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000356031.3_Missense_Mutation_p.H1417N			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1417					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGCTCGCTATCACATTGAAAC	0.333000													4	46					0.00909568	0.00992256	1	1	0
TPO	7173	broad.mit.edu	37	2	1480950	1480950	+	Silent	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:1480950C>T	ENST00000345913.4	+	8	1003	c.912C>T	c.(910-912)ctC>ctT	p.L304L	TPO_ENST00000382198.1_Intron|TPO_ENST00000382201.3_Silent_p.L304L|TPO_ENST00000349624.3_Intron|TPO_ENST00000346956.3_Silent_p.L304L|TPO_ENST00000337415.3_Silent_p.L304L|TPO_ENST00000329066.4_Silent_p.L304L|TPO_ENST00000497517.2_Intron	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	304					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	AAGGCGCGCTCTTTGGGAACC	0.711000													4	20					0	0	1	0	0
TMEM209	84928	broad.mit.edu	37	7	129843832	129843832	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr7:129843832C>G	ENST00000397622.2	-	2	244	c.122G>C	c.(121-123)gGa>gCa	p.G41A	TMEM209_ENST00000473456.1_Missense_Mutation_p.G41A|RP11-775D22.3_ENST00000483283.1_RNA|TMEM209_ENST00000336804.8_Missense_Mutation_p.G40A|TMEM209_ENST00000462753.1_Missense_Mutation_p.G40A	NM_032842.3	NP_116231.2	Q96SK2	TM209_HUMAN	transmembrane protein 209	41						integral to membrane				NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	12	Melanoma(18;0.0435)					ATATATCATTCCAGCCATAGA	0.388000													3	16					0	0	1	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125299273	125299273	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chrX:125299273G>A	ENST00000538699.1	-	2	715	c.635C>T	c.(634-636)tCc>tTc	p.S212F	DCAF12L2_ENST00000360028.2_Missense_Mutation_p.S212F	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	212										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						GCCGTCGCGGGAGCCGCTCAC	0.642000													11	49					0	0	1	0	0
MT-CYB	4519	broad.mit.edu	37	MT	14831	14831	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chrM:14831G>A	ENST00000361789.2	+	1	85	c.85G>A	c.(85-87)Gca>Aca	p.29_29insT						mitochondrially encoded cytochrome b											breast(6)|endometrium(25)|kidney(33)|prostate(1)	65						CCAACATCTCCGCATGATGAA	0.483000													14	10					0	0	1	0	0
KIAA1715	80856	broad.mit.edu	37	2	176812295	176812295	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:176812295G>C	ENST00000272748.4	-	9	866	c.619C>G	c.(619-621)Ccc>Gcc	p.P207A	KIAA1715_ENST00000544803.1_Missense_Mutation_p.P207A|KIAA1715_ENST00000535310.1_Missense_Mutation_p.P132A	NM_030650.1	NP_085153.1	Q9C0E8	LNP_HUMAN	KIAA1715	207	Pro-rich.					integral to membrane	protein binding			endometrium(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)	20			OV - Ovarian serous cystadenocarcinoma(117;0.0793)			CTTTCTGGGGGTCCACCAGGG	0.522000													7	89					0	0	1	0	0
KLHL4	56062	broad.mit.edu	37	X	86773139	86773139	+	Silent	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chrX:86773139C>A	ENST00000373119.4	+	1	388	c.243C>A	c.(241-243)gcC>gcA	p.A81A	KLHL4_ENST00000373114.4_Silent_p.A81A	NM_019117.4	NP_061990.2	Q9C0H6	KLHL4_HUMAN	kelch-like family member 4	81						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(29)|ovary(2)|prostate(1)|skin(1)	67						CAGGACCGGCCCCTGCCCATC	0.473000													3	21					0.115264	0.121027	1	1	0
CRAMP1L	57585	broad.mit.edu	37	16	1706092	1706092	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr16:1706092C>T	ENST00000397412.3	+	10	1433	c.1334C>T	c.(1333-1335)gCc>gTc	p.A445V	CRAMP1L_ENST00000262317.4_Intron|LA16c-431H6.6_ENST00000454337.1_Intron|CRAMP1L_ENST00000436138.3_Missense_Mutation_p.A442V|CRAMP1L_ENST00000293925.5_Missense_Mutation_p.A445V			Q96RY5	CRML_HUMAN	Crm, cramped-like (Drosophila)	445						nucleus	DNA binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|lung(6)|pancreas(1)	22						CTGCCCCCAGCCCAGATCCTG	0.711000													7	18					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79590037	79590037	+	Silent	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr10:79590037C>A	ENST00000372391.2	-	11	1952	c.1947G>T	c.(1945-1947)ccG>ccT	p.P649P	DLG5_ENST00000372388.2_Silent_p.P649P	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	649	PDZ 1.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			CACAGTCCCCCGGGAAACAAG	0.507000													15	50					1.15088e-07	1.45011e-07	1	1	0
CPN1	1369	broad.mit.edu	37	10	101823387	101823387	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr10:101823387C>A	ENST00000370418.3	-	5	1106	c.855G>T	c.(853-855)tgG>tgT	p.W285C		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	285	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		TGAGAGAATACCAGGAAGCCC	0.493000													7	74					1.08611e-07	1.37537e-07	1	1	0
RPAP1	26015	broad.mit.edu	37	15	41823314	41823314	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr15:41823314C>T	ENST00000304330.4	-	7	966	c.850G>A	c.(850-852)Gga>Aga	p.G284R	RPAP1_ENST00000568413.1_5'UTR|RPAP1_ENST00000561603.1_Missense_Mutation_p.G284R	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	284						nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GCAGAGGGTCCTCCTGGCCTC	0.562000													43	134					0	0	1	0	0
LRFN1	57622	broad.mit.edu	37	19	39798589	39798589	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr19:39798589A>T	ENST00000248668.4	-	2	1999	c.2000T>A	c.(1999-2001)gTg>gAg	p.V667E		NM_020862.1	NP_065913.1	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III domain containing 1	667						cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				central_nervous_system(2)|cervix(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			TCGAGGGCCCACCGCGGCCCG	0.721000													3	1					0	0	1	0	0
MKNK2	2872	broad.mit.edu	37	19	2043524	2043524	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr19:2043524G>T	ENST00000250896.3	-	6	641	c.397C>A	c.(397-399)Ctg>Atg	p.L133M	MKNK2_ENST00000541165.1_Missense_Mutation_p.L2M|MKNK2_ENST00000309340.7_Missense_Mutation_p.L133M|MKNK2_ENST00000591601.1_Missense_Mutation_p.L133M	NM_199054.2	NP_951009.1	Q9HBH9	MKNK2_HUMAN	MAP kinase interacting serine/threonine kinase 2	133	Protein kinase.				cell surface receptor linked signaling pathway|intracellular protein kinase cascade|regulation of translation		ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(1)|kidney(3)|large_intestine(3)|lung(3)	10		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACTGGTACAGCATCTCCACC	0.592000													22	44					9.80776e-20	1.50705e-19	1	1	0
CHD7	55636	broad.mit.edu	37	8	61774771	61774771	+	Missense_Mutation	SNP	T	T	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr8:61774771T>G	ENST00000423902.2	+	36	8326	c.7847T>G	c.(7846-7848)cTg>cGg	p.L2616R	CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2616					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GCAGATGTGCTGTTTTCCTCA	0.338000													3	6					0	0	1	0	0
FAM208B	54906	broad.mit.edu	37	10	5777329	5777329	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr10:5777329G>A	ENST00000328090.5	+	12	1892	c.1267G>A	c.(1267-1269)Gct>Act	p.A423T	RP11-336A10.2_ENST00000411512.2_RNA	NM_017782.4	NP_060252.4	Q5VWN6	CJ018_HUMAN	family with sequence similarity 208, member B	423																	AAACCAAGAAGCTCCTATTTC	0.418000													19	79					0	0	1	0	0
RBM15	64783	broad.mit.edu	37	1	110884206	110884206	+	Nonsense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:110884206C>T	ENST00000369784.3	+	1	3079	c.2179C>T	c.(2179-2181)Cga>Tga	p.R727*	RBM15_ENST00000487146.2_Nonsense_Mutation_p.R727*|RBM15_ENST00000602849.1_Nonsense_Mutation_p.R727*	NM_022768.4	NP_073605.4	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	727	Arg-rich.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		ATCAGCTGAACGAGATAGGAA	0.522000			T	MKL1	acute megakaryocytic leukemia								11	68					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15809106	15809106	+	Nonsense_Mutation	SNP	G	G	T	rs148621523		TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr16:15809106G>T	ENST00000338282.6	-	39	5634	c.5528C>A	c.(5527-5529)tCg>tAg	p.S1843*	MYH11_ENST00000576790.1_Nonsense_Mutation_p.S1843*|MYH11_ENST00000452625.2_Nonsense_Mutation_p.S1850*|MYH11_ENST00000396324.3_Nonsense_Mutation_p.S1850*|MYH11_ENST00000300036.5_Nonsense_Mutation_p.S1843*|NDE1_ENST00000342673.5_Intron|NDE1_ENST00000396355.1_Intron|NDE1_ENST00000396354.1_Intron	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1843					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						CTGCTTCAGCGACTTGGTGGC	0.577000			T	CBFB	AML								20	79					1.55469e-16	2.29113e-16	1	1	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77509890	77509890	+	Splice_Site	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:77509890C>A	ENST00000477717.1	+	3	498	c.261_splice	c.e3-1	p.P88_splice		NM_030965.1	NP_112227.1	Q9BVH7	SIA7E_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	88					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	18						GCCTTCCAGCCCCTGAAAATG	0.587000													5	36					0.00116845	0.00129713	1	1	0
RP1L1	94137	broad.mit.edu	37	8	10468811	10468811	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr8:10468811C>A	ENST00000382483.3	-	4	3020	c.2797G>T	c.(2797-2799)Ggc>Tgc	p.G933C		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	933					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		CCCTGGGGGCCTCCCCCACTC	0.662000													9	58					2.74318e-10	3.69669e-10	1	1	0
PGM2L1	283209	broad.mit.edu	37	11	74049637	74049637	+	Missense_Mutation	SNP	C	C	A	rs146628692	by1000genomes	TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr11:74049637C>A	ENST00000298198.4	-	13	1953	c.1642G>T	c.(1642-1644)Gtg>Ttg	p.V548L		NM_173582.3	NP_775853.2	Q6PCE3	PGM2L_HUMAN	phosphoglucomutase 2-like 1	548					glucose 1-phosphate metabolic process	cytosol	glucose-1,6-bisphosphate synthase activity|phosphoglucomutase activity			NS(2)|breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	Breast(11;3.32e-06)					TTTTTACTCACAGGCAGCACC	0.338000													17	70					4.63292e-17	6.86763e-17	1	1	0
ABCF1	23	broad.mit.edu	37	6	30546297	30546297	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr6:30546297G>T	ENST00000326195.8	+	6	544	c.432G>T	c.(430-432)gaG>gaT	p.E144D	ABCF1_ENST00000396515.4_Intron|ABCF1_ENST00000376545.3_Missense_Mutation_p.E144D	NM_001025091.1	NP_001020262.1	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 1	144	Glu-rich.				inflammatory response|translational initiation	nuclear envelope|nucleoplasm|polysomal ribosome	ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(3)|skin(2)	21						AGGAAGAGGAGGAGGAAGAAA	0.488000													8	32					3.09899e-07	3.88529e-07	1	1	0
POSTN	10631	broad.mit.edu	37	13	38164596	38164596	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr13:38164596G>C	ENST00000379747.4	-	4	471	c.354C>G	c.(352-354)gaC>gaG	p.D118E	POSTN_ENST00000379743.4_Missense_Mutation_p.D118E|POSTN_ENST00000379749.4_Missense_Mutation_p.D118E|POSTN_ENST00000541179.1_Missense_Mutation_p.D118E|POSTN_ENST00000379742.4_Missense_Mutation_p.D118E|POSTN_ENST00000541481.1_Missense_Mutation_p.D118E	NM_006475.2	NP_006466.2	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor	118	FAS1 1.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding	p.D118D(1)		cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		GTTTTGAGGCGTCAGAATAGC	0.458000													5	22					0	0	1	0	0
HHIPL1	84439	broad.mit.edu	37	14	100129270	100129270	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr14:100129270C>G	ENST00000330710.5	+	6	1658	c.1560C>G	c.(1558-1560)atC>atG	p.I520M	HHIPL1_ENST00000357223.2_Missense_Mutation_p.I520M	NM_001127258.1	NP_001120730.1	Q96JK4	HIPL1_HUMAN	HHIP-like 1	520					carbohydrate metabolic process	extracellular region|membrane	oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor|quinone binding|scavenger receptor activity			breast(1)|endometrium(2)|large_intestine(2)|lung(8)|skin(2)	15		Melanoma(154;0.128)				ACAGTGAGATCTGCATGGGCC	0.592000													16	45					0	0	1	0	0
CEBPD	1052	broad.mit.edu	37	8	48649914	48649914	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr8:48649914G>C	ENST00000408965.3	-	1	1734	c.769C>G	c.(769-771)Ccg>Gcg	p.P257A		NM_005195.3	NP_005186.2	P49716	CEBPD_HUMAN	CCAAT/enhancer binding protein (C/EBP), delta	257					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)	1		all_cancers(86;0.0782)|Lung NSC(58;0.00363)|all_epithelial(80;0.0042)|all_lung(54;0.00914)				AGGAAGGGCGGGCTGGGCAGC	0.711000													5	13					0	0	1	0	0
FOLH1B	219595	broad.mit.edu	37	11	89395322	89395322	+	RNA	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr11:89395322C>T	ENST00000532352.1	+	0	720							Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B						proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(26)|ovary(4)|skin(4)|urinary_tract(2)	48						TTTCAGAATACGCTTATAGGC	0.343000													3	26					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	109805345	109805345	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr4:109805345G>T	ENST00000399132.1	-	19	1539	c.1009C>A	c.(1009-1011)Ccg>Acg	p.P337T	COL25A1_ENST00000399126.1_Missense_Mutation_p.P337T|COL25A1_ENST00000399127.1_Missense_Mutation_p.P333T	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	337	Collagen-like 4.					collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		TTTATCCCCGGAAGTCCAGGA	0.413000													4	30					0.014758	0.0158932	1	1	0
MCM6	4175	broad.mit.edu	37	2	136609003	136609003	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:136609003T>A	ENST00000264156.2	-	13	1946	c.1886A>T	c.(1885-1887)gAa>gTa	p.E629V	MCM6_ENST00000492091.1_5'UTR	NM_005915.5	NP_005906.2	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	629					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(15)|prostate(2)|skin(1)	29				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	AGCCATAGCTTCAGAGAGACG	0.438000													12	26					0	0	1	0	0
CLSTN1	22883	broad.mit.edu	37	1	9791826	9791826	+	Silent	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:9791826C>T	ENST00000377298.4	-	17	3348	c.2556G>A	c.(2554-2556)ccG>ccA	p.P852P	CLSTN1_ENST00000361311.4_Silent_p.P842P|CLSTN1_ENST00000477264.1_5'UTR|CLSTN1_ENST00000377288.3_Silent_p.P833P	NM_001009566.1	NP_001009566.1	O94985	CSTN1_HUMAN	calsyntenin 1	852					homophilic cell adhesion	cell junction|cell projection|endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus|postsynaptic membrane	calcium ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(9)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	36	all_lung(157;0.222)	all_lung(284;4.03e-05)|Lung NSC(185;6.93e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;8.36e-08)|COAD - Colon adenocarcinoma(227;1.93e-05)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(304;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|STAD - Stomach adenocarcinoma(132;0.00644)|READ - Rectum adenocarcinoma(331;0.0419)		TACCTGCGAACGGGTGGGGGT	0.652000													30	91					0	0	1	0	0
PRPF19	27339	broad.mit.edu	37	11	60666028	60666028	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr11:60666028C>A	ENST00000227524.4	-	13	1330	c.1125G>T	c.(1123-1125)aaG>aaT	p.K375N		NM_014502.4	NP_055317.1	Q9UMS4	PRP19_HUMAN	pre-mRNA processing factor 19	375					DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	22						AGTCCCAGATCTTGATCTGAG	0.542000													13	55					1.02788e-11	1.42322e-11	1	1	0
MASP1	5648	broad.mit.edu	37	3	186947573	186947573	+	Silent	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr3:186947573C>T	ENST00000337774.5	-	11	1805	c.1416G>A	c.(1414-1416)caG>caA	p.Q472Q		NM_001879.5	NP_001870.3	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	472	Peptidase S1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		CGCAGAAGGGCTGCCCATTCA	0.567000													5	33					0	0	1	0	0
SP100	6672	broad.mit.edu	37	2	231314306	231314306	+	Missense_Mutation	SNP	A	A	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:231314306A>G	ENST00000264052.5	+	7	972	c.617A>G	c.(616-618)gAg>gGg	p.E206G	SP100_ENST00000427101.2_Missense_Mutation_p.E181G|SP100_ENST00000409341.1_Missense_Mutation_p.E206G|SP100_ENST00000409112.1_Missense_Mutation_p.E206G|SP100_ENST00000409897.1_Missense_Mutation_p.E171G|SP100_ENST00000341950.4_Missense_Mutation_p.E206G|SP100_ENST00000409824.1_Missense_Mutation_p.E181G|SP100_ENST00000340126.4_Missense_Mutation_p.E206G	NM_003113.3	NP_003104.2	P23497	SP100_HUMAN	SP100 nuclear antigen	206					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(4)|upper_aerodigestive_tract(1)	25		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		GGACTCTCAGAGCACCCCTGT	0.438000													8	35					0	0	1	0	0
KIF25	3834	broad.mit.edu	37	6	168430272	168430272	+	Missense_Mutation	SNP	T	T	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr6:168430272T>A	ENST00000443060.2	+	3	398	c.7T>A	c.(7-9)Tgg>Agg	p.W3R	KIF25_ENST00000354419.2_Missense_Mutation_p.W3R|KIF25_ENST00000351261.3_Missense_Mutation_p.W3R			Q9UIL4	KIF25_HUMAN	kinesin family member 25	3	Kinesin-motor.				microtubule-based movement|mitotic sister chromatid segregation	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity	p.W3R(1)		NS(2)|breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		Breast(66;1.07e-05)|Ovarian(120;0.0728)		Epithelial(4;7.7e-30)|OV - Ovarian serous cystadenocarcinoma(33;5.82e-22)|BRCA - Breast invasive adenocarcinoma(4;1.38e-10)|GBM - Glioblastoma multiforme(31;0.000756)		CCAGATGACATGGACCTCAGG	0.612000													4	143					0	0	1	0	0
SLC1A3	6507	broad.mit.edu	37	5	36608564	36608564	+	Silent	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr5:36608564C>T	ENST00000265113.4	+	2	515	c.39C>T	c.(37-39)ggC>ggT	p.G13G	SLC1A3_ENST00000506725.1_3'UTR|SLC1A3_ENST00000381918.3_Silent_p.G13G	NM_004172.4	NP_004163.3	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity glutamate transporter), member 3	13					D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|liver(1)|lung(23)|skin(1)	41	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	AGATGGGGGGCAGGATGGAGA	0.448000													6	90					0	0	1	0	0
CD1D	912	broad.mit.edu	37	1	158152818	158152818	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:158152818T>C	ENST00000368171.3	+	5	1257	c.758T>C	c.(757-759)aTc>aCc	p.I253T		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	253	Ig-like.				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					CCAGGGGACATCCTGCCCAAT	0.602000													13	225					0	0	1	0	0
SRSF11	9295	broad.mit.edu	37	1	70715710	70715710	+	Silent	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:70715710C>T	ENST00000370950.3	+	11	1180	c.1098C>T	c.(1096-1098)tcC>tcT	p.S366S	SRSF11_ENST00000370949.1_Silent_p.S306S|SRSF11_ENST00000484162.1_3'UTR|SRSF11_ENST00000370951.1_Silent_p.S366S|SRSF11_ENST00000405432.1_Silent_p.S366S			Q05519	SRS11_HUMAN	serine/arginine-rich splicing factor 11	366					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding			large_intestine(3)|ovary(2)|skin(1)	6						GAAAATTGTCCCGCTCACCAT	0.373000													8	31					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	13359	13359	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chrM:13359G>A	ENST00000361567.2	+	1	1023	c.1023G>A	c.(1021-1023)atG>atA	p.M341I				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	341					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	ATACTATTTATGTGCTCCGGG	0.438000													8	4					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24197078	24197078	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr8:24197078C>G	ENST00000265769.4	+	15	1777	c.1667C>G	c.(1666-1668)gCa>gGa	p.A556G	RP11-624C23.1_ENST00000519689.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|RP11-624C23.1_ENST00000518988.1_RNA|RP11-624C23.1_ENST00000523700.1_RNA|ADAM28_ENST00000397649.3_Missense_Mutation_p.A303G	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	556	Cys-rich.				proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		CCCTGCAAAGCAAAGTAAGTG	0.458000													5	18					0	0	1	0	0
CDHR1	92211	broad.mit.edu	37	10	85972117	85972117	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr10:85972117G>A	ENST00000372117.3	+	15	1839	c.1736G>A	c.(1735-1737)aGc>aAc	p.S579N	CDHR1_ENST00000332904.3_Missense_Mutation_p.S579N|CDHR1_ENST00000440770.2_Missense_Mutation_p.S283N	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	579	Cadherin 6.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						TTTGGAAAGAGCGTTCAGAAG	0.512000													14	110					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57573277	57573277	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr12:57573277G>A	ENST00000243077.3	+	29	5370	c.4904G>A	c.(4903-4905)cGg>cAg	p.R1635Q		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1635					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	TCTGACGTGCGGACACAGGCC	0.587000													8	54					0	0	1	0	0
AMOT	154796	broad.mit.edu	37	X	112024168	112024168	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chrX:112024168C>A	ENST00000371959.3	-	9	2418	c.2419G>T	c.(2419-2421)Ggc>Tgc	p.G807C	AMOT_ENST00000524145.1_Missense_Mutation_p.G807C|AMOT_ENST00000304758.1_Missense_Mutation_p.G398C|AMOT_ENST00000371958.1_Missense_Mutation_p.G575C|AMOT_ENST00000371962.1_Missense_Mutation_p.G575C	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	807					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						ATGGGGGAGCCAGTCAGGGTG	0.512000													25	136					2.12542e-12	2.97558e-12	1	1	0
PLEC	5339	broad.mit.edu	37	8	144990735	144990735	+	Silent	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr8:144990735G>A	ENST00000322810.4	-	32	13834	c.13665C>T	c.(13663-13665)gaC>gaT	p.D4555D	PLEC_ENST00000356346.3_Silent_p.D4404D|PLEC_ENST00000354958.2_Silent_p.D4396D|PLEC_ENST00000436759.2_Silent_p.D4445D|PLEC_ENST00000354589.3_Silent_p.D4418D|PLEC_ENST00000398774.2_Silent_p.D4386D|PLEC_ENST00000357649.2_Silent_p.D4422D|PLEC_ENST00000345136.3_Silent_p.D4418D|PLEC_ENST00000527096.1_Silent_p.D4441D	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4555	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CGGTGCGGGCGTCCACCGTGC	0.672000													16	57					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176012969	176012969	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr5:176012969A>T	ENST00000510636.1	+	20	3023	c.2749A>T	c.(2749-2751)Acc>Tcc	p.T917S	CDHR2_ENST00000261944.5_Missense_Mutation_p.T917S|CDHR2_ENST00000506348.1_Missense_Mutation_p.T917S	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	917	Cadherin 8.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						CCTCCTCATTACCATTGAGGA	0.517000													9	90					0	0	1	0	0
EBF3	253738	broad.mit.edu	37	10	131636201	131636201	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr10:131636201G>T	ENST00000368648.3	-	16	1720	c.1648C>A	c.(1648-1650)Cca>Aca	p.P550T	EBF3_ENST00000355311.5_Missense_Mutation_p.P595T	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	595	Pro/Ser/Thr-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CCTCACATTGGCGGGACTACC	0.572000													15	48					5.35267e-07	6.64469e-07	1	1	0
MAT1A	4143	broad.mit.edu	37	10	82034280	82034280	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr10:82034280C>A	ENST00000372213.3	-	8	1341	c.1081G>T	c.(1081-1083)Gtc>Ttc	p.V361F	MAT1A_ENST00000485270.1_5'UTR	NM_000429.2	NP_000420.1	Q00266	METK1_HUMAN	methionine adenosyltransferase I, alpha	361					methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity			endometrium(4)|large_intestine(7)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26			Colorectal(32;0.229)		L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	CTTTACCTGACAATGACGCCC	0.537000													27	88					2.42023e-17	3.60887e-17	1	1	0
OR4A47	403253	broad.mit.edu	37	11	48510632	48510632	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr11:48510632G>T	ENST00000446524.1	+	1	364	c.288G>T	c.(286-288)atG>atT	p.M96I		NM_001005512.2	NP_001005512.2	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A, member 47	96					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(18)|ovary(1)|skin(1)|urinary_tract(2)	29						AATCTTGCATGGCCCAGCTCT	0.428000													23	109					1.22384e-17	1.84675e-17	1	1	0
GYPA	2993	broad.mit.edu	37	4	145039898	145039898	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr4:145039898C>G	ENST00000360771.4	-	4	355	c.240G>C	c.(238-240)agG>agC	p.R80S	GYPA_ENST00000324022.10_Missense_Mutation_p.R47S|RP11-673E1.4_ENST00000506982.1_RNA|GYPA_ENST00000512064.1_Intron|GYPA_ENST00000503627.1_Intron|GYPA_ENST00000535709.1_Missense_Mutation_p.R54S|GYPA_ENST00000512789.1_Missense_Mutation_p.R15S|GYPB_ENST00000283126.7_Intron|GYPA_ENST00000504786.1_Missense_Mutation_p.R48S	NM_002099.6	NP_002090.4	P02724	GLPA_HUMAN	glycophorin A (MNS blood group)	80					interspecies interaction between organisms	membrane fraction	receptor activity			central_nervous_system(2)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	10	all_hematologic(180;0.15)					CAAGTTGTACCCTTTCTCCTA	0.328000													11	49					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38951108	38951108	+	Silent	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr19:38951108G>A	ENST00000355481.4	+	20	2585	c.2454G>A	c.(2452-2454)gaG>gaA	p.E818E	RYR1_ENST00000360985.3_Silent_p.E818E|RYR1_ENST00000359596.3_Silent_p.E818E	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	818					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCCCTCGAGAGCGACTCCATC	0.637000													29	129					0	0	1	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68964643	68964643	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr4:68964643C>A	ENST00000356291.2	-	2	184	c.125G>T	c.(124-126)gGa>gTa	p.G42V		NM_207407.2	NP_997290.2	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	42					proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(4)	39						AATTGCAATTCCTATGATTGC	0.383000													11	60					2.23348e-06	2.70595e-06	1	1	0
ALDOB	229	broad.mit.edu	37	9	104192165	104192165	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr9:104192165C>T	ENST00000374855.4	-	3	320	c.196G>A	c.(196-198)Gtg>Atg	p.V66M	ALDOB_ENST00000468981.2_Intron	NM_000035.3	NP_000026.2	P05062	ALDOB_HUMAN	aldolase B, fructose-bisphosphate	66					fructose 1,6-bisphosphate metabolic process|fructose catabolic process|gluconeogenesis|glycolysis|NADH oxidation|positive regulation of ATPase activity|vacuolar proton-transporting V-type ATPase complex assembly	centriolar satellite|cytosol	ATPase binding|cytoskeletal protein binding|fructose binding|fructose-bisphosphate aldolase activity|identical protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|liver(1)|lung(5)|prostate(2)|skin(4)|urinary_tract(1)	24		Acute lymphoblastic leukemia(62;0.0559)				GAACTGTCCACAGAGAAGAGG	0.542000													34	76					0	0	1	0	0
GIMAP2	26157	broad.mit.edu	37	7	150384165	150384165	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr7:150384165C>A	ENST00000223293.5	+	2	112	c.18C>A	c.(16-18)caC>caA	p.H6Q	GIMAP2_ENST00000474605.1_Missense_Mutation_p.H6Q	NM_015660.2	NP_056475.1	Q9UG22	GIMA2_HUMAN	GTPase, IMAP family member 2	6						integral to membrane	GTP binding			kidney(1)|large_intestine(1)|lung(8)|skin(2)|urinary_tract(1)	13			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AAAATGAACACAGTCACTGGG	0.393000													3	52					1	1	1	1	0
ZDBF2	57683	broad.mit.edu	37	2	207174040	207174040	+	Missense_Mutation	SNP	A	A	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:207174040A>T	ENST00000374423.3	+	5	5174	c.4788A>T	c.(4786-4788)caA>caT	p.Q1596H		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1596							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						TGACAAACCAATGCAAAGAGA	0.338000													3	12					0	0	1	0	0
ZNF624	57547	broad.mit.edu	37	17	16526104	16526104	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr17:16526104T>C	ENST00000311331.7	-	6	2187	c.2096A>G	c.(2095-2097)aAt>aGt	p.N699S		NM_020787.3	NP_065838.2	Q9P2J8	ZN624_HUMAN	zinc finger protein 624	699					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(1)|prostate(1)|skin(1)	26				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		TCCACATTCATTGCATTTATA	0.378000													21	67					0	0	1	0	0
TRIM9	114088	broad.mit.edu	37	14	51561184	51561184	+	Nonsense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr14:51561184G>T	ENST00000298355.3	-	1	1595	c.474C>A	c.(472-474)taC>taA	p.Y158*	TRIM9_ENST00000360392.4_Nonsense_Mutation_p.Y158*|TRIM9_ENST00000338969.5_Nonsense_Mutation_p.Y158*	NM_015163.5	NP_055978.4	Q9C026	TRIM9_HUMAN	tripartite motif containing 9	158					proteasomal ubiquitin-dependent protein catabolic process	cell junction|cytoskeleton|dendrite|synaptic vesicle	protein homodimerization activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_epithelial(31;0.00418)|Breast(41;0.148)					TGCTCTGCTGGTAGCGGTCAA	0.617000													9	15					4.68919e-08	6.02896e-08	1	1	0
SLC4A5	57835	broad.mit.edu	37	2	74459673	74459673	+	Silent	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:74459673G>A	ENST00000394019.2	-	24	3094	c.2697C>T	c.(2695-2697)tcC>tcT	p.S899S	SLC4A5_ENST00000423644.1_Intron|SLC4A5_ENST00000359484.4_Silent_p.S797S|SLC4A5_ENST00000377632.1_Silent_p.S899S|SLC4A5_ENST00000377634.4_Silent_p.S899S|SLC4A5_ENST00000358683.4_Silent_p.S797S|SLC4A5_ENST00000357822.5_Silent_p.S899S|SLC4A5_ENST00000346834.4_Silent_p.S899S|SLC4A5_ENST00000483195.1_Intron|RP11-287D1.3_ENST00000451608.2_3'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	899						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						TGTGGGCGATGGAGATGACCG	0.622000													16	102					0	0	1	0	0
OR5M3	219482	broad.mit.edu	37	11	56237432	56237432	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr11:56237432G>T	ENST00000312240.2	-	1	582	c.542C>A	c.(541-543)cCt>cAt	p.P181H		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	181					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					TTTGATGAGAGGTGGATCTGC	0.398000													29	132					6.50621e-10	8.67495e-10	1	1	0
ZNF536	9745	broad.mit.edu	37	19	31039059	31039059	+	Missense_Mutation	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr19:31039059C>A	ENST00000355537.3	+	4	2680	c.2533C>A	c.(2533-2535)Ctc>Atc	p.L845I		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	845					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding	p.L845V(1)		NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CTTCAAGGGTCTCCCTGGAAT	0.572000													15	70					8.10497e-08	1.03154e-07	1	1	0
RPAP1	26015	broad.mit.edu	37	15	41823313	41823313	+	Missense_Mutation	SNP	C	C	G			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr15:41823313C>G	ENST00000304330.4	-	7	967	c.851G>C	c.(850-852)gGa>gCa	p.G284A	RPAP1_ENST00000568413.1_5'UTR|RPAP1_ENST00000561603.1_Missense_Mutation_p.G284A	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	284						nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		AGCAGAGGGTCCTCCTGGCCT	0.567000													42	134					0	0	1	0	0
CNTNAP5	129684	broad.mit.edu	37	2	125261888	125261888	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:125261888G>T	ENST00000431078.1	+	8	1443	c.1079G>T	c.(1078-1080)tGc>tTc	p.C360F		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	360	Laminin G-like 1.				cell adhesion|signal transduction	integral to membrane	receptor binding	p.C360F(1)		NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		ACTTTTTCCTGCTCCGAACCA	0.458000													9	63					5.16669e-11	7.07611e-11	1	1	0
CLEC4F	165530	broad.mit.edu	37	2	71044012	71044012	+	Silent	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:71044012C>T	ENST00000272367.2	-	4	577	c.501G>A	c.(499-501)caG>caA	p.Q167Q	CLEC4F_ENST00000426626.1_Silent_p.Q167Q	NM_001258027.1|NM_173535.2	NP_001244956.1|NP_775806.2	Q8N1N0	CLC4F_HUMAN	C-type lectin domain family 4, member F	167					endocytosis	integral to membrane	receptor activity|sugar binding			endometrium(1)|large_intestine(5)|lung(18)|ovary(5)|prostate(5)|skin(1)|upper_aerodigestive_tract(2)	37						TCCTTAACATCTGTGTCTGCA	0.468000													7	48					0	0	1	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147030044	147030044	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr5:147030044C>T	ENST00000265272.5	-	4	1161	c.694G>A	c.(694-696)Ggc>Agc	p.G232S	JAKMIP2_ENST00000333010.6_Missense_Mutation_p.G190S|JAKMIP2_ENST00000507386.1_Missense_Mutation_p.G232S	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	232						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTACATAGCCTGTCTGGGTC	0.438000													4	50					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43579515	43579515	+	Nonsense_Mutation	SNP	G	G	T	rs145520726		TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr15:43579515G>T	ENST00000452443.2	-	6	832	c.828C>A	c.(826-828)taC>taA	p.Y276*		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	276					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	AGCACTGTCCGTACTTCACAG	0.557000													5	31					1	1	1	1	0
PPP1R11	6992	broad.mit.edu	37	6	30035192	30035192	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr6:30035192C>T	ENST00000376772.3	+	1	328	c.5C>T	c.(4-6)gCc>gTc	p.A2V	PPP1R11_ENST00000376773.1_Intron|PPP1R11_ENST00000376769.2_5'UTR	NM_021959.2	NP_068778.1	O60927	PP1RB_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 11	2						soluble fraction	protein binding|protein phosphatase inhibitor activity			lung(2)|ovary(1)|prostate(1)|skin(2)	6						TTAGCCATGGCCGAGGCAGGG	0.607000													4	127					0	0	1	0	0
ZNF496	84838	broad.mit.edu	37	1	247464398	247464398	+	Missense_Mutation	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:247464398C>T	ENST00000294753.4	-	9	1651	c.1187G>A	c.(1186-1188)gGa>gAa	p.G396E	ZNF496_ENST00000366498.2_Missense_Mutation_p.G432E|ZNF496_ENST00000462139.1_5'UTR	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496	396					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			CACCTCGCCTCCGGCCTCGGT	0.647000													3	61					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53907791	53907791	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr15:53907791G>A	ENST00000396328.1	-	15	2851	c.2612C>T	c.(2611-2613)tCa>tTa	p.S871L	WDR72_ENST00000559418.1_Missense_Mutation_p.S881L|WDR72_ENST00000557913.1_Missense_Mutation_p.S868L|WDR72_ENST00000360509.5_Missense_Mutation_p.S871L	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	871										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		GTATTTATCTGACAAGTCCAA	0.348000													7	66					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240492663	240492663	+	Silent	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:240492663C>A	ENST00000319653.9	+	10	4562	c.4332C>A	c.(4330-4332)atC>atA	p.I1444I	FMN2_ENST00000545751.1_Silent_p.I40I	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1444	FH2.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TGTCACTAATCCCCAACTTTT	0.358000													11	81					8.60227e-14	1.24585e-13	1	1	0
FYCO1	79443	broad.mit.edu	37	3	46009257	46009257	+	Silent	SNP	T	T	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr3:46009257T>C	ENST00000296137.2	-	8	1774	c.1569A>G	c.(1567-1569)gcA>gcG	p.A523A	FYCO1_ENST00000535325.1_Silent_p.A523A	NM_024513.3	NP_078789.2	Q9BQS8	FYCO1_HUMAN	FYVE and coiled-coil domain containing 1	523					transport	integral to membrane	metal ion binding|protein binding			NS(4)|breast(3)|central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(9)|lung(17)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	54				BRCA - Breast invasive adenocarcinoma(193;0.00147)|KIRC - Kidney renal clear cell carcinoma(197;0.0272)|Kidney(197;0.0323)		GGCTCACCTGTGCCAGCTGGG	0.587000													26	78					0	0	1	0	0
SHROOM2	357	broad.mit.edu	37	X	9864516	9864516	+	Silent	SNP	C	C	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chrX:9864516C>T	ENST00000380913.3	+	4	2658	c.2568C>T	c.(2566-2568)agC>agT	p.S856S		NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	856					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				ACGCTCACAGCGCAGCGGAGA	0.652000													3	23					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131829908	131829908	+	Missense_Mutation	SNP	G	G	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr7:131829908G>T	ENST00000359827.3	-	29	6157	c.5195C>A	c.(5194-5196)cCg>cAg	p.P1732Q	PLXNA4_ENST00000321063.4_Missense_Mutation_p.P1732Q			Q9HCM2	PLXA4_HUMAN	plexin A4	1732						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						GCGGACGTGCGGGTCATGAAT	0.582000													14	79					2.5808e-16	3.78117e-16	1	1	0
SCRN2	90507	broad.mit.edu	37	17	45917625	45917625	+	Silent	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr17:45917625G>A	ENST00000407215.3	-	3	369	c.288C>T	c.(286-288)ggC>ggT	p.G96G	SCRN2_ENST00000584123.1_Silent_p.G104G|SCRN2_ENST00000290216.9_Silent_p.G96G			Q96FV2	SCRN2_HUMAN	secernin 2	96					proteolysis		dipeptidase activity			cervix(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	14						CAGCCTCGTTGCCAATGCAGA	0.607000													25	111					0	0	1	0	0
UBE2O	63893	broad.mit.edu	37	17	74396592	74396592	+	Missense_Mutation	SNP	T	T	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr17:74396592T>C	ENST00000319380.7	-	7	998	c.934A>G	c.(934-936)Agt>Ggt	p.S312G		NM_022066.3	NP_071349.3	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	312							ATP binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36						GGACAGAAACTCTTGGTAATC	0.572000													5	39					0	0	1	0	0
GPR123	84435	broad.mit.edu	37	10	134898429	134898429	+	Silent	SNP	C	C	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr10:134898429C>A	ENST00000607359.1	+	8	1491	c.1491C>A	c.(1489-1491)cgC>cgA	p.R497R				Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	0						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		CTCATGGCCGCGTGAGCCGCT	0.592000													22	65					7.07758e-08	9.05355e-08	1	1	0
DOCK4	9732	broad.mit.edu	37	7	111375194	111375194	+	Missense_Mutation	SNP	G	G	C			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr7:111375194G>C	ENST00000428084.1	-	51	5607	c.5335C>G	c.(5335-5337)Ctg>Gtg	p.L1779V	DOCK4_ENST00000437633.1_Missense_Mutation_p.L1770V|DOCK4_ENST00000494651.2_Missense_Mutation_p.L653V			Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	1770	Ser-rich.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(4)|large_intestine(13)|lung(31)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(4)	72		Acute lymphoblastic leukemia(1;0.0441)				CCACTGTCCAGGCTCCAGCTG	0.512000													4	16					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155783529	155783529	+	Missense_Mutation	SNP	G	G	A			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:155783529G>A	ENST00000437809.1	-	10	1470	c.1348C>T	c.(1348-1350)Ccc>Tcc	p.P450S	GON4L_ENST00000361040.5_Missense_Mutation_p.P450S|GON4L_ENST00000271883.5_Missense_Mutation_p.P450S|GON4L_ENST00000368331.1_Missense_Mutation_p.P450S|GON4L_ENST00000471341.1_5'UTR			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	450	Poly-Pro.				regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					TTTGGAGGGGGCGGGGGCCCC	0.512000													9	60					0	0	1	0	0
LCE1D	353134	broad.mit.edu	37	1	152770558	152770558	+	Frame_Shift_Del	DEL	G	G	-	rs41268496	byFrequency	TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:152770558delG	ENST00000326233.6	+	2	331	c.288delG	c.(286-288)tcfs	p.S96fs		NM_178352.2	NP_848129.1	Q5T752	LCE1D_HUMAN	late cornified envelope 1D	96	Cys-rich.				cellular response to calcium ion|keratinization	cornified envelope|perinuclear region of cytoplasm				large_intestine(1)	1	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCAGCCCTCGGGGGGCTCCA	0.657													16	45	---	---	---	---					
WDR26	80232	broad.mit.edu	37	1	224621773	224621775	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr1:224621773_224621775delCCT	ENST00000414423.2	-	1	226_228	c.33_35delAGG	c.(31-36)ggt>gg	p.GG23del	WDR26_ENST00000366852.2_In_Frame_Del_p.GG23del|WDR26_ENST00000295024.6_5'UTR	NM_001115113.2|NM_025160.6	NP_001108585.2|NP_079436.4	Q9H7D7	WDR26_HUMAN	WD repeat domain 26	23						cytoplasm|nucleus				biliary_tract(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)	18				GBM - Glioblastoma multiforme(131;0.0104)		gccgccgccacctcctcctcctc	0.739													2	4	---	---	---	---					
CGREF1	10669	broad.mit.edu	37	2	27324636	27324637	+	Frame_Shift_Ins	INS	-	-	T			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr2:27324636_27324637insT	ENST00000402394.1	-	6	730_731	c.462_463insA	c.(460-465)gaccctfs	p.D154fs	CGREF1_ENST00000312734.4_Frame_Shift_Ins_p.D154fs|CGREF1_ENST00000404694.3_Frame_Shift_Ins_p.D276fs|CGREF1_ENST00000452318.2_Intron|CGREF1_ENST00000405600.1_Frame_Shift_Ins_p.D154fs|CGREF1_ENST00000402550.1_Intron|CGREF1_ENST00000260595.5_Frame_Shift_Ins_p.D154fs	NM_006569.5	NP_006560.3	Q99674	CGRE1_HUMAN	cell growth regulator with EF-hand domain 1	154					cell adhesion|cell cycle arrest|negative regulation of cell proliferation|response to stress	extracellular region	calcium ion binding			kidney(1)|lung(4)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGAGCAAGGGGCTCTCCGGGCT	0.579													16	76	---	---	---	---					
XKR4	114786	broad.mit.edu	37	8	56436675	56436675	+	Frame_Shift_Del	DEL	A	A	-			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr8:56436675delA	ENST00000327381.5	+	3	1942	c.1842delA	c.(1840-1842)cgfs	p.R614fs		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	614						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			TTTTGGACCGAAGCCTCCGAA	0.473													31	55	---	---	---	---					
PCSK5	5125	broad.mit.edu	37	9	78749062	78749062	+	Frame_Shift_Del	DEL	G	G	-			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr9:78749062delG	ENST00000545128.1	+	10	1784	c.1246delG	c.(1246-1248)tcfs	p.V416fs	PCSK5_ENST00000376767.3_Frame_Shift_Del_p.V416fs|PCSK5_ENST00000376752.4_Frame_Shift_Del_p.V416fs	NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	416	Catalytic.				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						GCATGTTATTGTCAGGACTTC	0.438													30	74	---	---	---	---					
MLEC	9761	broad.mit.edu	37	12	121125148	121125150	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr12:121125148_121125150delCTG	ENST00000228506.3	+	1	477_479	c.49_51delCTG	c.(49-51)del	p.L22del	MLEC_ENST00000412616.2_In_Frame_Del_p.L22del	NM_014730.2	NP_055545.1	Q14165	MLEC_HUMAN	malectin	22					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	16						gctcctgcgactgctgctgctgc	0.783													3	5	---	---	---	---					
OLFM4	10562	broad.mit.edu	37	13	53603037	53603037	+	Frame_Shift_Del	DEL	G	G	-			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr13:53603037delG	ENST00000219022.2	+	1	144	c.66delG	c.(64-66)ttfs	p.L22fs		NM_006418.4	NP_006409.3	Q6UX06	OLFM4_HUMAN	olfactomedin 4	22					cell adhesion	extracellular space				breast(2)|endometrium(4)|kidney(4)|large_intestine(5)|lung(20)|skin(3)|urinary_tract(1)	39		Breast(56;0.000776)|Lung NSC(96;0.000814)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.13e-08)		CAGGGGATTTGGGGGATGTGG	0.602													50	193	---	---	---	---					
NINL	22981	broad.mit.edu	37	20	25484662	25484663	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr20:25484662_25484663delAG	ENST00000278886.6	-	7	859_860	c.786_787delCT	c.(784-789)cttcfs	p.LF262fs	NINL_ENST00000422516.1_Frame_Shift_Del_p.LF262fs	NM_025176.4	NP_079452.3	Q9Y2I6	NINL_HUMAN	ninein-like	262	EF-hand 4.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(13)|lung(25)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	57						TCATGACTGAAGAGGCCAAGCT	0.465													36	127	---	---	---	---					
RP5-1121H13.4	0	broad.mit.edu	37	20	40627647	40627649	+	RNA	DEL	CTG	CTG	-			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chr20:40627647_40627649delCTG	ENST00000431589.1	+	0	131																											CGCGGCCCGCCTGCTGCTGCTGC	0.714													2	4	---	---	---	---					
SMARCA1	6594	broad.mit.edu	37	X	128633737	128633738	+	Frame_Shift_Ins	INS	-	-	GC			TCGA-99-8033-01A-11D-2238-08	TCGA-99-8033-10A-01D-2238-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	72ea55f8-2d6c-4dad-b90b-c3676a683a52	e32d68f6-c93c-4281-8910-b19ee8adf079	g.chrX:128633737_128633738insGC	ENST00000371122.4	-	10	1377_1378	c.1248_1249insGC	c.(1246-1251)tatgggfs	p.YG416fs	SMARCA1_ENST00000371121.3_Frame_Shift_Ins_p.YG416fs|SMARCA1_ENST00000371123.1_Frame_Shift_Ins_p.YG416fs	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	416					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						CTCAGCCCCAAGTAAATCTTTA	0.317													18	111	---	---	---	---					
