Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MXRA5	25878	broad.mit.edu	37	X	3238940	3238940	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:3238940C>G	ENST00000217939.6	-	5	4940	c.4786G>C	c.(4786-4788)Gat>Cat	p.D1596H		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1596						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ACTCTTCCATCCTGGCGTTGG	0.488000													9	141					0	0	1	0	0
COG5	10466	broad.mit.edu	37	7	106843977	106843977	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:106843977A>G	ENST00000347053.3	-	21	2554	c.2504T>C	c.(2503-2505)aTg>aCg	p.M835T	COG5_ENST00000297135.3_Missense_Mutation_p.M856T	NM_181733.2	NP_859422.2	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5	835					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(2)|skin(4)|stomach(1)	40						AAGAGCAGACATAGCCTTTTG	0.413000													40	33					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219252560	219252560	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:219252560G>C	ENST00000233202.6	+	8	1017	c.677G>C	c.(676-678)cGg>cCg	p.R226P	SLC11A1_ENST00000539932.1_Missense_Mutation_p.R108P	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	226					activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCGCTTCTTCGGGGCCTGTTC	0.672000													8	14					0	0	1	0	0
OR10Q1	219960	broad.mit.edu	37	11	57996236	57996236	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:57996236G>A	ENST00000316770.2	-	1	154	c.112C>T	c.(112-114)Ctc>Ttc	p.L38F		NM_001004471.2	NP_001004471.1	Q8NGQ4	O10Q1_HUMAN	olfactory receptor, family 10, subfamily Q, member 1	38					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)	35		Breast(21;0.0589)				ATCAAGTAGAGGAGGAGGAAG	0.522000													32	122					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29602234	29602234	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:29602234G>T	ENST00000373779.3	+	8	1548	c.1419G>T	c.(1417-1419)gaG>gaT	p.E473D	PTPRU_ENST00000356870.3_Missense_Mutation_p.E473D|PTPRU_ENST00000345512.3_Missense_Mutation_p.E473D|PTPRU_ENST00000460170.2_Missense_Mutation_p.E473D|PTPRU_ENST00000428026.2_Missense_Mutation_p.E473D|PTPRU_ENST00000323874.8_Missense_Mutation_p.E473D	NM_001195001.1|NM_133178.3	NP_001181930.1|NP_573439.2	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	473	Fibronectin type-III 2.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		GGCGCAAAGAGGGCAAGGAGG	0.562000													5	28					0.217242	0.21964	1	1	0
TTN	7273	broad.mit.edu	37	2	179472023	179472023	+	Missense_Mutation	SNP	A	A	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:179472023A>C	ENST00000589042.1	-	278	53530	c.53306T>G	c.(53305-53307)cTt>cGt	p.L17769R	TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.L8704R|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.L8829R|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.L15201R|TTN_ENST00000591111.1_Missense_Mutation_p.L16128R|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.L8896R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16128	Ig-like 104.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTAAGTCAAGAACTGGACC	0.358000													10	90					0	0	1	0	0
EHMT2	10919	broad.mit.edu	37	6	31855418	31855418	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:31855418G>T	ENST00000395728.3	-	14	2117	c.2118C>A	c.(2116-2118)ttC>ttA	p.F706L	EHMT2_ENST00000375528.4_Missense_Mutation_p.F672L|EHMT2_ENST00000375537.4_Missense_Mutation_p.F649L|EHMT2_ENST00000375530.4_Missense_Mutation_p.F615L|EHMT2_ENST00000480912.1_5'UTR			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	649					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						GCCGAGGGTGGAAACGGAGCT	0.607000													31	74					2.4375e-19	3.10104e-19	1	1	0
OR8U1	219417	broad.mit.edu	37	11	56143722	56143722	+	Missense_Mutation	SNP	T	T	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:56143722T>A	ENST00000302270.1	+	1	623	c.623T>A	c.(622-624)aTt>aAt	p.I208N		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1											NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					ATCATGTTCATTTCCTCCCTT	0.463000													9	92					0	0	1	0	0
MYCBP2	23077	broad.mit.edu	37	13	77664249	77664249	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr13:77664249C>G	ENST00000407578.2	-	60	10783	c.10517G>C	c.(10516-10518)gGa>gCa	p.G3506A	MYCBP2-AS1_ENST00000593933.1_RNA|MYCBP2_ENST00000544440.2_Missense_Mutation_p.G3468A|MYCBP2_ENST00000357337.6_Missense_Mutation_p.G3468A	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	3468					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ACCAGTGTCTCCACTGTTAAC	0.294000													14	76					0	0	1	0	0
CNOT4	4850	broad.mit.edu	37	7	135047834	135047834	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:135047834C>T	ENST00000541284.1	-	12	2275	c.1945G>A	c.(1945-1947)Gct>Act	p.A649T	CNOT4_ENST00000473470.1_5'UTR|CNOT4_ENST00000361528.4_Missense_Mutation_p.A575T|CNOT4_ENST00000451834.1_Missense_Mutation_p.A646T|CNOT4_ENST00000423368.2_Missense_Mutation_p.A578T	NM_001190849.1|NM_001190850.1	NP_001177778.1|NP_001177779.1	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	313					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	22						GATGGAGCAGCGCTGGGGCCG	0.562000													57	103					0	0	1	0	0
GC	2638	broad.mit.edu	37	4	72622615	72622615	+	Missense_Mutation	SNP	A	A	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:72622615A>T	ENST00000273951.8	-	8	1191	c.848T>A	c.(847-849)gTa>gAa	p.V283E	GC_ENST00000513476.1_Missense_Mutation_p.V283E|GC_ENST00000503472.1_5'UTR|GC_ENST00000504199.1_Missense_Mutation_p.V302E	NM_000583.3|NM_001204306.1	NP_000574.2|NP_001191235.1	P02774	VTDB_HUMAN	group-specific component (vitamin D binding protein)	283	Albumin 2.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	45		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	ACAGAGTTTTACTGTGTGTTC	0.348000													5	54					0	0	1	0	0
SEPT3	55964	broad.mit.edu	37	22	42385625	42385625	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr22:42385625C>G	ENST00000396425.3	+	6	737	c.606C>G	c.(604-606)atC>atG	p.I202M	SEPT3_ENST00000406029.1_Missense_Mutation_p.I138M|SEPT3_ENST00000328414.8_3'UTR|SEPT3_ENST00000396426.3_Missense_Mutation_p.I202M|SEPT3_ENST00000291236.11_Missense_Mutation_p.I138M	NM_019106.5	NP_061979.3	Q9UH03	SEPT3_HUMAN	septin 3	202					cell cycle|cytokinesis	cell junction|septin complex	GTP binding			breast(1)|kidney(3)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17						TTGTGAACATCATCCCTGTCA	0.517000													13	89					0	0	1	0	0
KCTD8	386617	broad.mit.edu	37	4	44176969	44176969	+	Silent	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:44176969G>T	ENST00000360029.3	-	2	1543	c.1260C>A	c.(1258-1260)tcC>tcA	p.S420S		NM_198353.2	NP_938167.1	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerization domain containing 8	420						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(3)|upper_aerodigestive_tract(4)	41						TTGTTTCCCGGGACTTGCTGA	0.413000										HNSCC(17;0.042)			67	166					3.57465e-26	4.62483e-26	1	1	0
CNKSR1	10256	broad.mit.edu	37	1	26515821	26515821	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:26515821C>G	ENST00000531191.1	+	20	2157	c.1150C>G	c.(1150-1152)Ctg>Gtg	p.L384V	CNKSR1_ENST00000361530.6_Missense_Mutation_p.L642V|CNKSR1_ENST00000374253.5_Missense_Mutation_p.L649V			Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras 1	649					Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	28		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		TGACCCTGAGCTGACAGGAGA	0.622000													10	55					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25664327	25664327	+	Splice_Site	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:25664327C>T	ENST00000382051.3	+	3	163	c.112_splice	c.e3-1	p.T38_splice	SLC34A2_ENST00000503434.1_Intron|SLC34A2_ENST00000504570.1_Intron	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	38					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				CTTGTTTCAGCAGATAACACT	0.507000			T	ROS1	NSCLC								11	191					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1061873	1061873	+	Silent	SNP	G	G	T	rs138392525		TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:1061873G>T	ENST00000263094.6	+	41	5787	c.5556G>T	c.(5554-5556)gtG>gtT	p.V1852V	ABCA7_ENST00000435683.2_Silent_p.V1714V|ABCA7_ENST00000433129.1_Silent_p.V1852V	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	1852	ABC transporter 2.				phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCGAGGCTGTGCTGGCAGGCC	0.642000													13	20					7.93312e-07	8.77625e-07	1	1	0
POM121	9883	broad.mit.edu	37	7	72413896	72413896	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:72413896A>G	ENST00000395270.1	+	14	3610	c.2569A>G	c.(2569-2571)Acc>Gcc	p.T857A	POM121_ENST00000434423.2_Missense_Mutation_p.T1122A|POM121_ENST00000446813.1_Missense_Mutation_p.T857A|POM121_ENST00000257622.4_Missense_Mutation_p.T857A|POM121_ENST00000358357.3_Missense_Mutation_p.T857A	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	1122	Pore side (Potential).|Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore		p.T857A(8)		NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				AGGCTCCAGCACCACCACCGG	0.637000													3	38					0	0	1	0	0
HOOK1	51361	broad.mit.edu	37	1	60312834	60312834	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:60312834G>A	ENST00000371208.3	+	10	1163	c.906G>A	c.(904-906)ctG>ctA	p.L302L	HOOK1_ENST00000465876.1_3'UTR|HOOK1_ENST00000395561.2_Silent_p.L260L	NM_015888.4	NP_056972.1	Q9UJC3	HOOK1_HUMAN	hook microtubule-tethering protein 1	302	Sufficient for interaction with microtubules.				early endosome to late endosome transport|endosome organization|endosome to lysosome transport|lysosome organization|microtubule cytoskeleton organization|multicellular organismal development|protein transport	FHF complex|microtubule	identical protein binding			biliary_tract(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|urinary_tract(1)	29	all_cancers(7;0.000129)					CAAGAGCCCTGAAAGATGAAA	0.328000													23	89					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85518101	85518101	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:85518101G>C	ENST00000393217.2	+	17	3872	c.3811G>C	c.(3811-3813)Gtc>Ctc	p.V1271L		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1271										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		GATGGACTCTGTCTCCAGCCA	0.453000													31	104					0	0	1	0	0
KRT78	196374	broad.mit.edu	37	12	53242447	53242447	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:53242447G>T	ENST00000304620.4	-	1	331	c.268C>A	c.(268-270)Cag>Aag	p.Q90K		NM_173352.2	NP_775487.2	Q8N1N4	K2C78_HUMAN	keratin 78	90	Head.					keratin filament	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	18						AGCAGATTCTGGTTGATGGTC	0.617000													7	45					1.06961e-07	1.20364e-07	1	1	0
TRAV22	28661	broad.mit.edu	37	14	22539218	22539218	+	RNA	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr14:22539218G>C	ENST00000390450.3	+	0	211																											AAGTGGAGCAGAGTCCTCCAG	0.468000													7	74					0	0	1	0	0
RHBDD2	57414	broad.mit.edu	37	7	75511148	75511148	+	Splice_Site	SNP	T	T	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:75511148T>G	ENST00000006777.6	+	2	315	c.178_splice	c.e2-1	p.V60_splice	RHBDD2_ENST00000318622.4_5'UTR|RHBDD2_ENST00000468304.1_Intron	NM_001040456.1	NP_001035546.1	Q6NTF9	RHBD2_HUMAN	rhomboid domain containing 2	60						integral to membrane	serine-type endopeptidase activity			kidney(1)|lung(4)|prostate(1)	6						CCTCTGCAGTTTACAGGCTGG	0.582000													30	89					0	0	1	0	0
VWA3B	200403	broad.mit.edu	37	2	98928442	98928442	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:98928442T>C	ENST00000477737.1	+	27	3886	c.3682T>C	c.(3682-3684)Tcc>Ccc	p.S1228P	VWA3B_ENST00000490947.2_3'UTR	NM_144992.4	NP_659429.4	Q502W6	VWA3B_HUMAN	von Willebrand factor A domain containing 3B	1228										NS(3)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						GGACGGCTCCTCCCACGGCAT	0.642000													4	9					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	62959980	62959980	+	Missense_Mutation	SNP	C	C	A	rs112699430	by1000genomes	TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:62959980C>A	ENST00000251157.5	-	40	5189	c.5156G>T	c.(5155-5157)cGg>cTg	p.R1719L	DOCK7_ENST00000340370.5_Missense_Mutation_p.R1697L	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1728	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						AAGATATTTCCGGTCCTCCAG	0.428000													10	36					2.17888e-05	2.34255e-05	1	1	0
DLX5	1749	broad.mit.edu	37	7	96651595	96651595	+	Nonsense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:96651595G>A	ENST00000222598.4	-	2	915	c.442C>T	c.(442-444)Cag>Tag	p.Q148*	DLX5_ENST00000493764.1_5'UTR|DLX5_ENST00000486603.2_Nonsense_Mutation_p.Q148*	NM_005221.5	NP_005212.1	P56178	DLX5_HUMAN	distal-less homeobox 5	148					cell proliferation|endochondral ossification|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)	20	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					GCGGCCAGCTGAAAGCTGGAA	0.498000													31	122					0	0	1	0	0
CBS	875	broad.mit.edu	37	21	44479404	44479404	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr21:44479404G>A	ENST00000398165.3	-	13	1414	c.1155C>T	c.(1153-1155)ttC>ttT	p.F385F	CBS_ENST00000398158.1_Silent_p.F385F|CBS_ENST00000544202.1_Silent_p.F297F|CBS_ENST00000352178.5_Silent_p.F385F|CBS_ENST00000359624.3_Silent_p.F385F|CBS_ENST00000398168.1_Silent_p.F385F	NM_000071.2	NP_000062.1	P35520	CBS_HUMAN	cystathionine-beta-synthase	385					cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(8)	17					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)	TGTCGCTCAGGAACTTGGTCC	0.687000													17	54					0	0	1	0	0
PLEKHM3	389072	broad.mit.edu	37	2	208865986	208865986	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:208865986C>T	ENST00000457206.1	-	2	805	c.378G>A	c.(376-378)cgG>cgA	p.R126R	PLEKHM3_ENST00000389247.4_Silent_p.R126R|PLEKHM3_ENST00000427836.2_Silent_p.R126R			Q6ZWE6	PKHM3_HUMAN	pleckstrin homology domain containing, family M, member 3	126					intracellular signal transduction		metal ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GCCGGTCCCTCCGACGCTGAC	0.463000													10	119					0	0	1	0	0
SRRM2	23524	broad.mit.edu	37	16	2813945	2813945	+	Missense_Mutation	SNP	A	A	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr16:2813945A>C	ENST00000301740.8	+	11	3965	c.3416A>C	c.(3415-3417)cAg>cCg	p.Q1139P		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	1139	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						AGCAGGTTCCAGTCTGACTCT	0.468000													25	86					0	0	1	0	0
PIH1D2	120379	broad.mit.edu	37	11	111941308	111941308	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:111941308G>C	ENST00000530641.1	-	5	990	c.665C>G	c.(664-666)tCc>tGc	p.S222C	PIH1D2_ENST00000431456.1_Missense_Mutation_p.S222C|PIH1D2_ENST00000280350.4_Missense_Mutation_p.S222C|PIH1D2_ENST00000532211.1_Missense_Mutation_p.S222C|PIH1D2_ENST00000528775.1_Missense_Mutation_p.S222C			Q8WWB5	PIHD2_HUMAN	PIH1 domain containing 2	222										endometrium(2)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	11		all_cancers(61;1.09e-14)|all_epithelial(67;7.64e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.19e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;6.18e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0508)		TTCAGTACTGGAAATCTCTTC	0.403000													17	198					0	0	1	0	0
RANBP2	5903	broad.mit.edu	37	2	109365543	109365543	+	Missense_Mutation	SNP	G	G	T	rs139907041		TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:109365543G>T	ENST00000283195.6	+	9	1357	c.1231G>T	c.(1231-1233)Gta>Tta	p.V411L		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	411					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						AAACATTGATGTACGAGAACC	0.378000													72	221					4.14589e-37	5.37909e-37	1	1	0
KMT2C	58508	broad.mit.edu	37	7	151902280	151902280	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:151902280C>A	ENST00000355193.2	-	25	4090	c.3872G>T	c.(3871-3873)aGt>aTt	p.S1291I	KMT2C_ENST00000262189.6_Missense_Mutation_p.S1291I					lysine (K)-specific methyltransferase 2C																		CCCAGTTCGACTTCTTTGCCG	0.398000													3	41					1	1	1	1	0
GPR156	165829	broad.mit.edu	37	3	119885888	119885888	+	Silent	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:119885888C>G	ENST00000464295.1	-	10	2881	c.2436G>C	c.(2434-2436)acG>acC	p.T812T	GPR156_ENST00000315843.3_Silent_p.T812T|GPR156_ENST00000461057.1_Silent_p.T808T			Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	812						integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|ovary(1)|prostate(1)|skin(1)	32				GBM - Glioblastoma multiforme(114;0.19)		TTCACACCAGCGTGGGTTTCA	0.542000													75	242					0	0	1	0	0
CHODL	140578	broad.mit.edu	37	21	19628934	19628934	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr21:19628934G>T	ENST00000299295.2	+	2	579	c.188G>T	c.(187-189)aGt>aTt	p.S63I	CHODL_ENST00000400135.1_Missense_Mutation_p.S22I|CHODL_ENST00000543733.1_Missense_Mutation_p.S44I|CHODL_ENST00000338326.3_Missense_Mutation_p.S22I|CHODL_ENST00000400127.1_Missense_Mutation_p.S22I|CHODL_ENST00000400131.1_Missense_Mutation_p.S22I|CHODL_ENST00000400128.1_Missense_Mutation_p.S22I	NM_001204175.1|NM_024944.2	NP_001191104.1|NP_079220.2	Q9H9P2	CHODL_HUMAN	chondrolectin	63	C-type lectin.				muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding			kidney(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		GCTTGTGAGAGTGAGGGAGGA	0.498000													24	44					5.35356e-11	6.4019e-11	1	1	0
EFCAB14	9813	broad.mit.edu	37	1	47148989	47148989	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:47148989C>G	ENST00000371933.3	-	10	2271	c.1295G>C	c.(1294-1296)gGa>gCa	p.G432A	EFCAB14_ENST00000544071.1_Missense_Mutation_p.G368A|EFCAB14-AS1_ENST00000418985.1_RNA|EFCAB14-AS1_ENST00000442839.1_RNA	NM_014774.2	NP_055589.1			EF-hand calcium binding domain 14																		GCTAGAAACTCCTGGTAGGGA	0.368000													20	90					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8384416	8384416	+	Silent	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:8384416G>T	ENST00000471889.1	+	2	412	c.27G>T	c.(25-27)ccG>ccT	p.P9P	SLC45A1_ENST00000289877.8_Silent_p.P9P|SLC45A1_ENST00000377479.2_Silent_p.P43P			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	9					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGCACCCCGCCGGGAGATG	0.672000													29	90					1.13719e-10	1.34235e-10	1	1	0
ZNF502	91392	broad.mit.edu	37	3	44762394	44762394	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:44762394G>C	ENST00000296091.4	+	4	341	c.85G>C	c.(85-87)Gag>Cag	p.E29Q	ZNF502_ENST00000436624.2_Missense_Mutation_p.E29Q|ZNF502_ENST00000449836.1_Missense_Mutation_p.E29Q	NM_001134440.1|NM_033210.4	NP_001127912.1|NP_149987.2	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(8)|lung(4)|prostate(1)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		GCCTGCTCTGGAGCAGGATGT	0.418000													26	67					0	0	1	0	0
KCNMB1	3779	broad.mit.edu	37	5	169812350	169812350	+	Silent	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr5:169812350C>A	ENST00000274629.4	-	2	544	c.102G>T	c.(100-102)ctG>ctT	p.L34L	KCNMB1_ENST00000521859.1_Silent_p.L34L|KCNIP1_ENST00000518527.1_Intron|KCNIP1_ENST00000377360.4_Intron	NM_004137.3	NP_004128.1	Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, beta member 1	34					platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			endometrium(1)|large_intestine(1)|lung(7)|ovary(2)	11	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)		CAGTCGTGACCAGGATGTAGT	0.592000													21	35					6.33239e-15	7.90254e-15	1	1	0
PDZD2	23037	broad.mit.edu	37	5	32074454	32074454	+	Nonsense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr5:32074454C>G	ENST00000438447.1	+	18	3630	c.3242C>G	c.(3241-3243)tCa>tGa	p.S1081*	PDZD2_ENST00000282493.3_Nonsense_Mutation_p.S1081*			O15018	PDZD2_HUMAN	PDZ domain containing 2	1081					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						CTGTCAGGATCAAGTAGCGCA	0.587000													48	249					0	0	1	0	0
PRICKLE1	144165	broad.mit.edu	37	12	42853979	42853979	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:42853979C>T	ENST00000455697.1	-	8	2413	c.2128G>A	c.(2128-2130)Gag>Aag	p.E710K	RP11-328C8.4_ENST00000547824.1_RNA|PRICKLE1_ENST00000552240.1_Missense_Mutation_p.E710K|PRICKLE1_ENST00000445766.2_Missense_Mutation_p.E710K|PRICKLE1_ENST00000548696.1_Missense_Mutation_p.E710K|PRICKLE1_ENST00000345127.3_Missense_Mutation_p.E710K	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	710					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		ATAAATTTCTCATAGTTATCG	0.473000													16	71					0	0	1	0	0
AMER1	139285	broad.mit.edu	37	X	63412428	63412428	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:63412428G>C	ENST00000330258.3	-	2	1011	c.739C>G	c.(739-741)Cca>Gca	p.P247A	AMER1_ENST00000403336.1_Missense_Mutation_p.P247A|AMER1_ENST00000374869.3_Missense_Mutation_p.P247A	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									GTAGCTGGTGGAGAAGGTTCT	0.537000													25	143					0	0	1	0	0
HGD	3081	broad.mit.edu	37	3	120401096	120401096	+	Translation_Start_Site	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:120401096G>A	ENST00000283871.5	-	0	322					NM_000187.3	NP_000178.2	Q93099	HGD_HUMAN	homogentisate 1,2-dioxygenase						L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	homogentisate 1,2-dioxygenase activity|metal ion binding			cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)	25				GBM - Glioblastoma multiforme(114;0.158)		TGGTCAGTGCGTCACTCAAAC	0.443000													17	21					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114449071	114449071	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr8:114449071G>A	ENST00000297405.5	-	1	257	c.13C>T	c.(13-15)Cgc>Tgc	p.R5C	CSMD3_ENST00000455883.2_Missense_Mutation_p.R5C|CSMD3_ENST00000352409.3_Missense_Mutation_p.R5C	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	5						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TCCCCTTTGCGGATCCCTTTC	0.537000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)	OREG0018933	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	153					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88381726	88381726	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:88381726G>A	ENST00000298699.2	-	9	898	c.718C>T	c.(718-720)Cat>Tat	p.H240Y	C12orf50_ENST00000550553.1_Intron	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	240										NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						TGCTTTGGATGAGGACTGTCC	0.333000													3	45					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29822269	29822269	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr10:29822269G>C	ENST00000375398.2	-	10	1476	c.1027C>G	c.(1027-1029)Cag>Gag	p.Q343E	SVIL_ENST00000355867.4_Missense_Mutation_p.Q343E|SVIL_ENST00000375400.3_Intron			O95425	SVIL_HUMAN	supervillin	343					cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				TGCTCAGACTGAAATGACACG	0.552000													7	62					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43546842	43546842	+	Silent	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:43546842T>C	ENST00000395891.1	+	22	4343	c.3738T>C	c.(3736-3738)ggT>ggC	p.G1246G	HECW1_ENST00000453890.1_Silent_p.G1212G	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1246					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						TTGGTCAGGGTCCGGGGAAAA	0.473000													9	74					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65178445	65178445	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr18:65178445G>A	ENST00000310045.7	-	2	4904	c.3431C>T	c.(3430-3432)cCt>cTt	p.P1144L	CTD-2541J13.2_ENST00000581951.1_RNA|CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	1134						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				AGTTTTCTGAGGAAAATGCAC	0.388000													20	31					0	0	1	0	0
WDR24	84219	broad.mit.edu	37	16	737292	737292	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr16:737292C>G	ENST00000293883.4	-	3	1543	c.784G>C	c.(784-786)Gag>Cag	p.E262Q	WDR24_ENST00000248142.6_Missense_Mutation_p.E392Q	NM_032259.2	NP_115635.1	Q96S15	WDR24_HUMAN	WD repeat domain 24	348								p.E262K(1)|p.E392K(1)		breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|urinary_tract(3)	19		Hepatocellular(780;0.0218)				TGGCGGCACTCTGGCCGCCAC	0.617000													17	57					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121732616	121732616	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:121732616C>T	ENST00000452319.1	+	9	1359	c.1299C>T	c.(1297-1299)gtC>gtT	p.V433V	GLI2_ENST00000435313.2_3'UTR|GLI2_ENST00000361492.4_Silent_p.V433V|GLI2_ENST00000314490.11_Silent_p.V105V			P10070	GLI2_HUMAN	GLI family zinc finger 2	433					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CTGAGGTGGTCATCTATGAGA	0.582000													9	64					0	0	1	0	0
OSBPL11	114885	broad.mit.edu	37	3	125271434	125271434	+	Silent	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:125271434G>T	ENST00000296220.5	-	9	1534	c.1245C>A	c.(1243-1245)atC>atA	p.I415I		NM_022776.4	NP_073613.2	Q9BXB4	OSB11_HUMAN	oxysterol binding protein-like 11	415					lipid transport		lipid binding			NS(1)|breast(1)|cervix(1)|kidney(2)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	27						CTCCATTAGTGATGGCTATAA	0.423000													12	164					0.000151284	0.000159283	1	1	0
CXorf23	256643	broad.mit.edu	37	X	19983618	19983618	+	Nonsense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:19983618G>T	ENST00000379687.3	-	3	851	c.818C>A	c.(817-819)tCa>tAa	p.S273*	CXorf23_ENST00000379682.4_Nonsense_Mutation_p.S273*|CXorf23_ENST00000356980.3_Nonsense_Mutation_p.S273*	NM_198279.3	NP_938020.2	A2AJT9	CX023_HUMAN	chromosome X open reading frame 23	273						mitochondrion				endometrium(2)|large_intestine(1)|lung(6)|skin(1)|urinary_tract(1)	11						TTTGGTTGCTGAACTGGTCTC	0.502000													35	94					2.68265e-12	3.2677e-12	1	1	0
DIP2B	57609	broad.mit.edu	37	12	51072622	51072622	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:51072622G>A	ENST00000301180.5	+	8	1111	c.1077G>A	c.(1075-1077)ctG>ctA	p.L359L		NM_173602.2	NP_775873.2	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B (Drosophila)	359						nucleus	catalytic activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						TGACTGCACTGGACATGACAG	0.488000													13	31					0	0	1	0	0
AKR7A3	22977	broad.mit.edu	37	1	19610511	19610511	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:19610511C>A	ENST00000361640.4	-	6	1353	c.813G>T	c.(811-813)atG>atT	p.M271I		NM_012067.2	NP_036199.2	O95154	ARK73_HUMAN	aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)	271					cellular aldehyde metabolic process	cytosol	aldo-keto reductase (NADP) activity|electron carrier activity			NS(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|ovary(1)|stomach(2)	13		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Breast(348;0.00049)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;1.78e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|GBM - Glioblastoma multiforme(114;0.00276)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		AGTGGTGGTACATCCACCGGA	0.592000													10	61					3.86212e-05	4.10406e-05	1	1	0
EIF2AK4	440275	broad.mit.edu	37	15	40293422	40293422	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr15:40293422G>A	ENST00000263791.5	+	21	3199	c.3156G>A	c.(3154-3156)ctG>ctA	p.L1052L	EIF2AK4_ENST00000382727.2_Silent_p.L1024L	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	1052	Histidyl-tRNA synthetase-like.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		GCGACATACTGAAGGTGGGCT	0.507000													6	24					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152553228	152553228	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:152553228C>G	ENST00000397345.3	-	17	1694	c.1492G>C	c.(1492-1494)Gat>Cat	p.D498H	NEB_ENST00000409198.1_Missense_Mutation_p.D498H|NEB_ENST00000604864.1_Missense_Mutation_p.D498H|NEB_ENST00000603639.1_Missense_Mutation_p.D498H|NEB_ENST00000427231.2_Missense_Mutation_p.D498H|NEB_ENST00000172853.10_Missense_Mutation_p.D498H	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	498					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTTGTCTTATCTGGATGGACT	0.458000													3	30					0	0	1	0	0
CDAN1	146059	broad.mit.edu	37	15	43020192	43020192	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr15:43020192T>C	ENST00000356231.3	-	22	2931	c.2908A>G	c.(2908-2910)Aca>Gca	p.T970A		NM_138477.2	NP_612486.2	Q8IWY9	CDAN1_HUMAN	codanin 1	970						integral to membrane	protein binding			endometrium(2)|kidney(4)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(3)	24		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		GCTTTCTCTGTTGCAAGCCCC	0.532000													110	233					0	0	1	0	0
KIF1B	23095	broad.mit.edu	37	1	10435365	10435365	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:10435365C>T	ENST00000377086.1	+	48	5544	c.5342C>T	c.(5341-5343)gCc>gTc	p.A1781V	KIF1B_ENST00000263934.6_Missense_Mutation_p.A1735V|KIF1B_ENST00000377081.1_Missense_Mutation_p.A1781V			O60333	KIF1B_HUMAN	kinesin family member 1B	1781	PH.				anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		CTTTTGCAGGCCCTCAATGAC	0.438000													26	69					0	0	1	0	0
LRP2	4036	broad.mit.edu	37	2	170044616	170044616	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:170044616C>T	ENST00000263816.3	-	49	9477	c.9192G>A	c.(9190-9192)ctG>ctA	p.L3064L		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3064	LDL-receptor class A 24.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ACAGGTGCATCAGCTCATCAG	0.512000													34	81					0	0	1	0	0
SYCP2L	221711	broad.mit.edu	37	6	10902980	10902980	+	Silent	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:10902980T>C	ENST00000283141.6	+	7	833	c.537T>C	c.(535-537)caT>caC	p.H179H	RP11-637O19.3_ENST00000480294.1_3'UTR|SYCP2L_ENST00000543878.1_Silent_p.H20H	NM_001040274.2	NP_001035364.2	Q5T4T6	SYC2L_HUMAN	synaptonemal complex protein 2-like	179						nucleus				breast(3)|central_nervous_system(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	36	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)	Epithelial(50;0.239)			CTGTAAATCATTTGCTTCAAC	0.363000													16	39					0	0	1	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70585343	70585343	+	Silent	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr8:70585343G>T	ENST00000260126.3	-	10	3014	c.2308C>A	c.(2308-2310)Cgg>Agg	p.R770R	SLCO5A1_ENST00000524945.1_3'UTR|SLCO5A1_ENST00000530307.1_Silent_p.R715R	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	770						integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			CTCTGCCTCCGCCTCTGCAGT	0.512000													27	80					2.48779e-11	2.99845e-11	1	1	0
CASS4	57091	broad.mit.edu	37	20	55028100	55028100	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr20:55028100A>G	ENST00000371336.3	+	5	2069	c.1868A>G	c.(1867-1869)cAa>cGa	p.Q623R	CASS4_ENST00000360314.3_Missense_Mutation_p.Q623R|CASS4_ENST00000434344.1_Intron	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	623					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						GAATCACACCAAAAGAGTACC	0.418000													21	46					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29120973	29120973	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr22:29120973C>T	ENST00000382580.2	-	5	788	c.713G>A	c.(712-714)aGa>aAa	p.R238K	CHEK2_ENST00000404276.1_Missense_Mutation_p.R195K|CHEK2_ENST00000348295.3_Missense_Mutation_p.R195K|CHEK2_ENST00000403642.1_Intron|CHEK2_ENST00000382566.1_Missense_Mutation_p.R195K|CHEK2_ENST00000382565.1_Intron|CHEK2_ENST00000328354.6_Missense_Mutation_p.R195K|CHEK2_ENST00000382578.1_Intron|CHEK2_ENST00000402731.1_Missense_Mutation_p.R195K|CHEK2_ENST00000544772.1_5'UTR|CHEK2_ENST00000405598.1_Missense_Mutation_p.R195K	NM_001005735.1	NP_001005735.1	O96017	CHK2_HUMAN	checkpoint kinase 2	195	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						ACCTTTATTTCTGCTTAGTGA	0.353000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					19	45					0	0	1	0	0
MARCO	8685	broad.mit.edu	37	2	119750741	119750741	+	Nonsense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:119750741C>T	ENST00000541757.1	+	17	1440	c.1060C>T	c.(1060-1062)Cga>Tga	p.R354*	MARCO_ENST00000327097.4_Nonsense_Mutation_p.R432*			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	432	Collagen-like.				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						CAGTAGTAACCGAGGCCGGGC	0.527000													15	124					0	0	1	0	0
APBA3	9546	broad.mit.edu	37	19	3759787	3759787	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:3759787G>C	ENST00000316757.3	-	2	676	c.476C>G	c.(475-477)tCt>tGt	p.S159C		NM_004886.3	NP_004877.1	O96018	APBA3_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 3	159					intracellular signal transduction|protein transport	intracellular|membrane	protein binding			endometrium(1)|large_intestine(1)|skin(1)	3		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00467)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCTCAGCAGAGGCCCCCTC	0.642000													15	23					0	0	1	0	0
EHMT2	10919	broad.mit.edu	37	6	31856762	31856762	+	Silent	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:31856762G>C	ENST00000395728.3	-	9	1370	c.1371C>G	c.(1369-1371)ctC>ctG	p.L457L	EHMT2_ENST00000375528.4_Intron|EHMT2_ENST00000375537.4_Silent_p.L400L|EHMT2_ENST00000375530.4_Intron|EHMT2_ENST00000480912.1_5'UTR			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	400					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						GGTTGGGGGAGAGGGTCCCCT	0.642000													6	10					0	0	1	0	0
CERKL	375298	broad.mit.edu	37	2	182468707	182468707	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:182468707C>A	ENST00000410087.3	-	2	438	c.338G>T	c.(337-339)aGa>aTa	p.R113I	CERKL_ENST00000374969.2_Missense_Mutation_p.R113I|CERKL_ENST00000374970.2_Missense_Mutation_p.R113I|CERKL_ENST00000479558.1_5'UTR|CERKL_ENST00000339098.5_Missense_Mutation_p.R113I|CERKL_ENST00000409440.3_Missense_Mutation_p.R113I	NM_001030311.2|NM_201548.4	NP_001025482.1|NP_963842.1	Q49MI3	CERKL_HUMAN	ceramide kinase-like	113					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|Golgi apparatus|nucleolus	diacylglycerol kinase activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(13)|ovary(3)|skin(3)	32			OV - Ovarian serous cystadenocarcinoma(117;0.088)			AGTACCACTTCTCTGCTGTTT	0.323000													3	36					0.004672	0.00486313	1	1	0
ZNF638	27332	broad.mit.edu	37	2	71653747	71653747	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:71653747A>G	ENST00000409544.1	+	24	5378	c.4748A>G	c.(4747-4749)aAg>aGg	p.K1583R	ZNF638_ENST00000409407.1_Missense_Mutation_p.K523R|ZNF638_ENST00000355812.3_3'UTR|ZNF638_ENST00000264447.4_Missense_Mutation_p.K1583R	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	1583	Poly-Lys.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						AAGAAGAAAAAGGGGAAAACT	0.418000													27	71					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3817811	3817811	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr16:3817811C>T	ENST00000262367.5	-	16	3969	c.3160G>A	c.(3160-3162)Gaa>Aaa	p.E1054K	CREBBP_ENST00000382070.3_Missense_Mutation_p.E1016K	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1054					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		ACTTTCACTTCAGGTTTCTTT	0.443000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						29	121					0	0	1	0	0
TUBA3D	113457	broad.mit.edu	37	2	132238200	132238200	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:132238200T>C	ENST00000321253.6	+	4	1041	c.934T>C	c.(934-936)Tac>Cac	p.Y312H		NM_080386.3	NP_525125.2	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	312					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32				BRCA - Breast invasive adenocarcinoma(221;0.13)		CCACGGCAAGTACATGGCCTG	0.582000													55	137					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3240148	3240148	+	Nonsense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:3240148G>T	ENST00000217939.6	-	5	3732	c.3578C>A	c.(3577-3579)tCa>tAa	p.S1193*		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1193						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CACTTGACTTGAAATCTTAAT	0.463000													11	102					3.86212e-05	4.10406e-05	1	1	0
TP53	7157	broad.mit.edu	37	17	7579518	7579518	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:7579518C>T	ENST00000420246.2	-	4	301	c.169G>A	c.(169-171)Gac>Aac	p.D57N	TP53_ENST00000455263.2_Missense_Mutation_p.D57N|TP53_ENST00000445888.2_Missense_Mutation_p.D57N|TP53_ENST00000269305.4_Missense_Mutation_p.D57N|TP53_ENST00000413465.2_Missense_Mutation_p.D57N|TP53_ENST00000359597.4_Missense_Mutation_p.D57N	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	57	Interaction with HRMT1L2.				activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.A63fs*66(3)|p.E51fs*59(1)|p.D48fs*55(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.D57_A76del20(1)|p.D57fs*86(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGACCTGGGTCTTCAGTGAAC	0.597000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			24	170					0	0	1	0	0
ACOT9	23597	broad.mit.edu	37	X	23722069	23722069	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:23722069T>C	ENST00000379303.5	-	16	1417	c.1289A>G	c.(1288-1290)cAt>cGt	p.H430R	ACOT9_ENST00000379295.1_Missense_Mutation_p.H361R|ACOT9_ENST00000336430.7_Missense_Mutation_p.H421R	NM_001037171.1	NP_001032248.1	Q9Y305	ACOT9_HUMAN	acyl-CoA thioesterase 9	421					acyl-CoA metabolic process	mitochondrion	acetyl-CoA hydrolase activity|carboxylesterase activity			breast(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(4)|pancreas(1)|skin(1)	15						GGAGTTGAAATGCCGCTGCCC	0.438000													8	30					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47872694	47872694	+	Missense_Mutation	SNP	T	T	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:47872694T>A	ENST00000289672.2	-	41	6381	c.6331A>T	c.(6331-6333)Act>Tct	p.T2111S		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	2111					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						TTACCTTGAGTGTGGGGAGGG	0.592000													6	10					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140228264	140228264	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr5:140228264C>T	ENST00000378122.3	+	1	908	c.184C>T	c.(184-186)Cgc>Tgc	p.R62C	PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.R62C|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA6_ENST00000529310.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGTGCCGCGCCTGTTCCA	0.627000													61	98					0	0	1	0	0
IGLV3-27	28791	broad.mit.edu	37	22	23011181	23011181	+	RNA	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr22:23011181G>T	ENST00000390304.2	+	0	282																											GCGATTCTCCGGCTCCAGCTC	0.562000													11	39					4.68919e-08	5.32915e-08	1	1	0
HCN1	348980	broad.mit.edu	37	5	45262728	45262728	+	Silent	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr5:45262728C>G	ENST00000303230.4	-	8	2025	c.1968G>C	c.(1966-1968)ccG>ccC	p.P656P		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	656						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TGCGGGAGGTCGGGGTCGTAG	0.557000													7	143					0	0	1	0	0
HOXB4	3214	broad.mit.edu	37	17	46654113	46654113	+	Silent	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:46654113G>T	ENST00000332503.5	-	2	2518	c.727C>A	c.(727-729)Cgg>Agg	p.R243R	HOXB3_ENST00000489475.1_Intron|HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000552000.2_Intron|HOXB3_ENST00000465120.3_Intron|HOXB3_ENST00000476342.1_Intron|HOXB3_ENST00000472863.1_Intron|HOXB3_ENST00000498678.1_Intron|HOXB3_ENST00000460160.1_Intron	NM_024015.4	NP_076920.1	P17483	HXB4_HUMAN	homeobox B4	243						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(2)|ovary(1)|urinary_tract(2)	9						CCATTGGGCCGGCCAGGGGGC	0.697000													13	29					9.05144e-12	1.09382e-11	1	1	0
IGSF1	3547	broad.mit.edu	37	X	130410953	130410953	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:130410953G>C	ENST00000370904.1	-	20	3451	c.2541C>G	c.(2539-2541)atC>atG	p.I847M	IGSF1_ENST00000361420.3_Missense_Mutation_p.I856M|IGSF1_ENST00000467244.1_5'UTR|IGSF1_ENST00000370903.3_Missense_Mutation_p.I861M|IGSF1_ENST00000370910.1_Missense_Mutation_p.I847M			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	856	Ig-like C2-type 8.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						GCTCAGACCAGATAGAAAAGT	0.572000													25	202					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149491977	149491977	+	RNA	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:149491977C>A	ENST00000378016.2	+	0	6178							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CATTCTGCCTCCGTCAGGAGG	0.627000													21	15					3.62473e-10	4.24585e-10	1	1	0
ATP10D	57205	broad.mit.edu	37	4	47548749	47548749	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:47548749G>T	ENST00000273859.3	+	10	1774	c.1505G>T	c.(1504-1506)aGg>aTg	p.R502M	ATP10D_ENST00000504445.1_Missense_Mutation_p.R487M	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	502					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						CCCAGCTGCAGGACAGTTCAT	0.478000													13	81					0.0202918	0.0208846	1	1	0
RDH11	51109	broad.mit.edu	37	14	68162372	68162372	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr14:68162372G>C	ENST00000381346.4	-	1	159	c.49C>G	c.(49-51)Ctg>Gtg	p.L17V	RDH11_ENST00000428130.2_Missense_Mutation_p.L17V|RDH11_ENST00000553384.1_Missense_Mutation_p.L17V	NM_001252650.1|NM_016026.3	NP_001239579.1|NP_057110.3	Q8TC12	RDH11_HUMAN	retinol dehydrogenase 11 (all-trans/9-cis/11-cis)	17					retinol metabolic process|steroid metabolic process	endoplasmic reticulum membrane|integral to membrane	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity	p.L17M(1)		breast(2)|endometrium(1)|kidney(3)|large_intestine(2)|lung(3)|ovary(1)	12				all cancers(60;0.00047)|OV - Ovarian serous cystadenocarcinoma(108;0.00206)|BRCA - Breast invasive adenocarcinoma(234;0.00924)	Vitamin A(DB00162)	GCCATATACAGAAGGAAGGGC	0.562000													9	18					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458305	248458305	+	Silent	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:248458305G>C	ENST00000317996.1	-	1	575	c.576C>G	c.(574-576)gtC>gtG	p.V192V		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	192					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			CGTTTTCGAAGACTGAAGTGT	0.532000													6	108					0	0	1	0	0
SERPING1	710	broad.mit.edu	37	11	57367687	57367687	+	Silent	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:57367687C>G	ENST00000403558.1	+	2	855	c.489C>G	c.(487-489)ctC>ctG	p.L163L	SERPING1_ENST00000340687.6_Silent_p.L129L|SERPING1_ENST00000378324.2_Silent_p.L77L|SERPING1_ENST00000278407.4_Silent_p.L129L|SERPING1_ENST00000378323.4_Silent_p.L134L	NM_001032295.1	NP_001027466.1	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	129					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(1)	27						CTGTTACTCTCTGCTCTGACT	0.547000													44	123					0	0	1	0	0
NMT1	4836	broad.mit.edu	37	17	43171164	43171164	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:43171164G>C	ENST00000592782.1	+	5	628	c.497G>C	c.(496-498)cGt>cCt	p.R166P	NMT1_ENST00000258960.2_Missense_Mutation_p.R166P|NMT1_ENST00000590114.1_3'UTR			P30419	NMT1_HUMAN	N-myristoyltransferase 1	166					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)	8		Prostate(33;0.155)				CTGGGCGATCGTGGTGTGGTG	0.597000													7	40					0	0	1	0	0
GRAMD1B	57476	broad.mit.edu	37	11	123480519	123480519	+	Silent	SNP	A	A	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:123480519A>T	ENST00000529750.1	+	12	1572	c.1245A>T	c.(1243-1245)ccA>ccT	p.P415P	GRAMD1B_ENST00000456860.2_Silent_p.P422P|GRAMD1B_ENST00000450171.2_Silent_p.P106P|GRAMD1B_ENST00000322282.7_Silent_p.P415P	NM_020716.1	NP_065767.1	Q3KR37	GRM1B_HUMAN	GRAM domain containing 1B	415						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(17)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	30		Breast(109;0.00204)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.32e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0394)		TCTTCCATCCATGGAAAAAGG	0.522000													3	14					0	0	1	0	0
SNX29	92017	broad.mit.edu	37	16	12136764	12136764	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr16:12136764C>G	ENST00000566228.1	+	5	327	c.258C>G	c.(256-258)ttC>ttG	p.F86L	SNX29_ENST00000568359.1_3'UTR	NM_032167.3	NP_115543.3	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	0					cell communication		phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	7						AGCCCGTGTTCTGGTACTACG	0.642000													4	44					0	0	1	0	0
MYOZ1	58529	broad.mit.edu	37	10	75391696	75391696	+	Nonsense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr10:75391696C>A	ENST00000359322.4	-	6	1256	c.892G>T	c.(892-894)Gag>Tag	p.E298*		NM_021245.3	NP_067068.1	Q9NP98	MYOZ1_HUMAN	myozenin 1	298					myofibril assembly	nucleus|pseudopodium	FATZ binding			central_nervous_system(1)|large_intestine(5)|lung(2)|ovary(2)|skin(2)	12	Prostate(51;0.0112)					CCTCACAGCTCCTCTGTTTCT	0.512000													10	24					2.74318e-10	3.22148e-10	1	1	0
BBS9	27241	broad.mit.edu	37	7	33427654	33427654	+	Silent	SNP	A	A	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:33427654A>C	ENST00000242067.6	+	19	2534	c.2013A>C	c.(2011-2013)gtA>gtC	p.V671V	BBS9_ENST00000354265.4_Silent_p.V636V|BBS9_ENST00000355070.2_Silent_p.V666V|BBS9_ENST00000350941.3_Silent_p.V631V|BBS9_ENST00000396127.2_Silent_p.V636V	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	671					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding		BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			AGAGAGCTGTACAATTTCGGG	0.393000									Bardet-Biedl syndrome				37	170					0	0	1	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr13:25161397C>G	ENST00000453498.1	+	0	921																											TGAAACATCTCTACAACTGGA	0.343000													3	31					0	0	1	0	0
HIST1H3B	8358	broad.mit.edu	37	6	26032136	26032136	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:26032136C>G	ENST00000244661.2	-	1	152	c.153G>C	c.(151-153)gaG>gaC	p.E51D		NM_003537.3	NP_003528.1	P68431	H31_HUMAN	histone cluster 1, H3b	51					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(3)|central_nervous_system(10)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	25						AGCGGCGGATCTCGCGCAGAG	0.627000													7	160					0	0	1	0	0
NAGS	162417	broad.mit.edu	37	17	42083066	42083066	+	Missense_Mutation	SNP	T	T	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:42083066T>A	ENST00000293404.3	+	2	606	c.488T>A	c.(487-489)tTc>tAc	p.F163Y		NM_153006.2	NP_694551.1	Q8N159	NAGS_HUMAN	N-acetylglutamate synthase	163					arginine biosynthetic process|urea cycle	mitochondrial matrix	acetyl-CoA:L-glutamate N-acetyltransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8		Breast(137;0.00536)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)	L-Glutamic Acid(DB00142)	GCCCTGGCCTTCTTGCAGCGC	0.657000													3	19					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60509269	60509269	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr20:60509269C>T	ENST00000360469.5	+	15	2623	c.2535C>T	c.(2533-2535)ttC>ttT	p.F845F	CDH4_ENST00000543233.1_Silent_p.F771F	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	845					adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			TCGGTGACTTCATCAATGAGG	0.612000													13	43					0	0	1	0	0
MCM2	4171	broad.mit.edu	37	3	127325523	127325523	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:127325523C>T	ENST00000265056.7	+	6	1208	c.964C>T	c.(964-966)Ctc>Ttc	p.L322F		NM_004526.2	NP_004517.2	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	322					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(2)|stomach(1)	6						CCTGCCCCAGCTCAGCATGGT	0.597000													8	116					0	0	1	0	0
ZNF648	127665	broad.mit.edu	37	1	182026850	182026850	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:182026850C>A	ENST00000339948.3	-	2	503	c.296G>T	c.(295-297)gGg>gTg	p.G99V		NM_001009992.1	NP_001009992.1	Q5T619	ZN648_HUMAN	zinc finger protein 648	99					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(7)|large_intestine(10)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	40						ACTGGCTTTCCCAGACATTTC	0.572000													8	106					1.12685e-05	1.22589e-05	1	1	0
PCDH10	57575	broad.mit.edu	37	4	134073432	134073432	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:134073432G>A	ENST00000264360.4	+	1	2963	c.2137G>A	c.(2137-2139)Gac>Aac	p.D713N		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	713					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		AACCTCGCTAGACCTCACCCT	0.662000													21	56					0	0	1	0	0
KNTC1	9735	broad.mit.edu	37	12	123067261	123067261	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:123067261G>C	ENST00000333479.7	+	34	3169	c.2992G>C	c.(2992-2994)Gag>Cag	p.E998Q	KNTC1_ENST00000450485.2_Intron	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	998					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		GGAGAACTTTGAGGTCTTTCT	0.353000													8	14					0	0	1	0	0
ZNF808	388558	broad.mit.edu	37	19	53057934	53057934	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:53057934C>A	ENST00000359798.4	+	5	1945	c.1765C>A	c.(1765-1767)Cat>Aat	p.H589N		NM_001039886.3	NP_001034975.2	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	589					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(8)|kidney(3)|lung(12)|urinary_tract(1)	24				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		TCGTAGACTTCATACTGGAGA	0.368000													17	68					8.28177e-16	1.03919e-15	1	1	0
CYTL1	54360	broad.mit.edu	37	4	5018897	5018897	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:5018897C>T	ENST00000307746.4	-	2	189	c.163G>A	c.(163-165)Gtg>Atg	p.V55M		NM_018659.2	NP_061129.1	Q9NRR1	CYTL1_HUMAN	cytokine-like 1	55					signal transduction	extracellular space|soluble fraction	receptor binding			breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		AGGTATCTCACACATGGCTCC	0.582000													6	36					0	0	1	0	0
NEXN	91624	broad.mit.edu	37	1	78395188	78395188	+	Splice_Site	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:78395188T>C	ENST00000330010.8	+	8	1157	c.861_splice	c.e8+1	p.M287_splice	NEXN_ENST00000334785.7_Splice_Site_p.M351_splice|NEXN_ENST00000457030.1_Splice_Site_p.M337_splice	NM_001172309.1	NP_001165780.1	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	351	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30				Colorectal(170;0.114)		AGGAGAAATATGGTAAGACAG	0.358000													22	55					0	0	1	0	0
TBRG4	9238	broad.mit.edu	37	7	45142079	45142079	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:45142079C>T	ENST00000258770.3	-	7	1309	c.1188G>A	c.(1186-1188)aaG>aaA	p.K396K	TBRG4_ENST00000361278.3_Silent_p.K286K|TBRG4_ENST00000395655.4_Silent_p.K286K|TBRG4_ENST00000494076.1_Silent_p.K396K	NM_004749.3	NP_004740.2	Q969Z0	TBRG4_HUMAN	transforming growth factor beta regulator 4	396					apoptosis|cell cycle arrest|cellular respiration|G1 phase of mitotic cell cycle|positive regulation of cell proliferation	mitochondrion	ATP binding|protein binding|protein kinase activity			cervix(1)|endometrium(3)|large_intestine(2)|lung(8)|skin(1)|stomach(2)	17						CTGACCCCAGCTTCTCATGTA	0.602000													13	54					0	0	1	0	0
BOD1L1	259282	broad.mit.edu	37	4	13603287	13603287	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:13603287C>G	ENST00000040738.5	-	10	5372	c.5237G>C	c.(5236-5238)gGa>gCa	p.G1746A		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	1746							DNA binding										GGGCCCTGCTCCAGTTACTGA	0.502000													70	166					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50294357	50294357	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr15:50294357G>C	ENST00000284509.6	-	8	640	c.499C>G	c.(499-501)Ctt>Gtt	p.L167V	ATP8B4_ENST00000559829.1_Missense_Mutation_p.L167V|ATP8B4_ENST00000558959.1_5'UTR	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	167					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TACCCATCAAGCTCAGCAGTT	0.299000													4	29					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553182	140553182	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr5:140553182C>G	ENST00000231137.3	+	1	940	c.766C>G	c.(766-768)Ccc>Gcc	p.P256A		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		256	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGAAAATAGCCCCGTTGGTTC	0.502000													14	47					0	0	1	0	0
HSD3B7	80270	broad.mit.edu	37	16	30999312	30999312	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr16:30999312G>C	ENST00000297679.5	+	7	1011	c.918G>C	c.(916-918)caG>caC	p.Q306H	HSD3B7_ENST00000262520.6_3'UTR|HSD3B7_ENST00000353250.5_3'UTR	NM_025193.3	NP_079469.2	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	306					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						CCCTGCTGCAGTGGCTGCTGC	0.677000													33	70					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108377956	108377956	+	Silent	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr10:108377956G>T	ENST00000263054.6	-	21	2878	c.2871C>A	c.(2869-2871)gtC>gtA	p.V957V	SORCS1_ENST00000369698.1_Silent_p.V492V|SORCS1_ENST00000478809.2_5'UTR|SORCS1_ENST00000344440.6_Silent_p.V957V	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	957						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TCCCAGCTGAGACCTGCACTG	0.468000													12	53					6.40141e-05	6.78668e-05	1	1	0
PIGG	54872	broad.mit.edu	37	4	517578	517578	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:517578C>T	ENST00000453061.2	+	9	2051	c.1945C>T	c.(1945-1947)Cgc>Tgc	p.R649C	PIGG_ENST00000296306.7_3'UTR|PIGG_ENST00000383028.4_Missense_Mutation_p.R516C|PIGG_ENST00000504346.1_Missense_Mutation_p.R560C|PIGG_ENST00000310340.5_Missense_Mutation_p.R641C	NM_001127178.1	NP_001120650.1	Q5H8A4	PIGG_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class G	649					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	CP2 mannose-ethanolamine phosphotransferase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	39						GCTCAGAGGCCGCGAGAAGTG	0.657000													3	32					0	0	1	0	0
EHMT2	10919	broad.mit.edu	37	6	31855825	31855825	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:31855825G>T	ENST00000395728.3	-	12	1908	c.1909C>A	c.(1909-1911)Cag>Aag	p.Q637K	EHMT2_ENST00000375528.4_Missense_Mutation_p.Q603K|EHMT2_ENST00000375537.4_Missense_Mutation_p.Q580K|EHMT2_ENST00000375530.4_Missense_Mutation_p.Q546K|EHMT2_ENST00000480912.1_5'UTR			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	580					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						TACCTGGGCTGAGAAGTGTCT	0.662000													4	13					0.150653	0.152992	1	1	0
OPRM1	4988	broad.mit.edu	37	6	154412220	154412220	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:154412220G>T	ENST00000414028.2	+	3	827	c.777G>T	c.(775-777)ttG>ttT	p.L259F	OPRM1_ENST00000428397.2_Missense_Mutation_p.L259F|OPRM1_ENST00000435918.2_Missense_Mutation_p.L259F|OPRM1_ENST00000522555.1_Missense_Mutation_p.L159F|OPRM1_ENST00000419506.2_Missense_Mutation_p.L259F|OPRM1_ENST00000229768.5_Missense_Mutation_p.L259F|OPRM1_ENST00000360422.4_Missense_Mutation_p.L259F|OPRM1_ENST00000452687.2_Missense_Mutation_p.L259F|OPRM1_ENST00000520708.1_Missense_Mutation_p.L159F|OPRM1_ENST00000330432.7_Missense_Mutation_p.L259F|OPRM1_ENST00000337049.4_Missense_Mutation_p.L259F|OPRM1_ENST00000518759.1_Missense_Mutation_p.L178F|OPRM1_ENST00000522236.1_Missense_Mutation_p.L159F|OPRM1_ENST00000434900.2_Missense_Mutation_p.L352F|OPRM1_ENST00000524163.1_Missense_Mutation_p.L259F	NM_001145284.2	NP_001138756.1	P35372	OPRM_HUMAN	opioid receptor, mu 1	259					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	TGATGATCTTGCGCCTCAAGA	0.502000													37	80					1.04352e-10	1.23496e-10	1	1	0
ARNT	405	broad.mit.edu	37	1	150808792	150808792	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:150808792G>C	ENST00000358595.5	-	7	864	c.664C>G	c.(664-666)Cgt>Ggt	p.R222G	ARNT_ENST00000515192.1_Missense_Mutation_p.R213G|ARNT_ENST00000505755.1_Missense_Mutation_p.R207G|ARNT_ENST00000468970.1_5'UTR|ARNT_ENST00000354396.2_Missense_Mutation_p.R222G	NM_001197325.1|NM_001668.3|NM_178427.2	NP_001184254.1|NP_001659.1|NP_848514.1	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	222	PAS 1.				positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|prostate(2)|skin(4)|stomach(1)	34	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			AGCTGCTCACGAAGTTTATCC	0.448000			T	ETV6	AML								9	68					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145293447	145293447	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:145293447G>C	ENST00000342960.5	+	1	77	c.42G>C	c.(40-42)gaG>gaC	p.E14D	NBPF10_ENST00000369339.2_Missense_Mutation_p.E14D|NBPF10_ENST00000369338.1_Intron|RP11-458D21.5_ENST00000468030.1_3'UTR	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	14										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGAAGGCAGAGATGAACATTC	0.493000													100	723					0	0	1	0	0
OXR1	55074	broad.mit.edu	37	8	107752683	107752683	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr8:107752683A>G	ENST00000445937.1	+	13	2456	c.2195A>G	c.(2194-2196)gAc>gGc	p.D732G	OXR1_ENST00000297447.6_Missense_Mutation_p.D129G|OXR1_ENST00000531443.1_Missense_Mutation_p.D732G|OXR1_ENST00000452423.2_Missense_Mutation_p.D180G|OXR1_ENST00000449762.2_Missense_Mutation_p.D102G|OXR1_ENST00000442977.2_Missense_Mutation_p.D760G|OXR1_ENST00000521592.1_Missense_Mutation_p.D5G|OXR1_ENST00000312046.6_Missense_Mutation_p.D725G|OXR1_ENST00000517566.2_Missense_Mutation_p.D759G	NM_018002.3	NP_060472.2	Q8N573	OXR1_HUMAN	oxidation resistance 1	760	TLD.				cell wall macromolecule catabolic process|response to oxidative stress	mitochondrion				NS(2)|breast(2)|endometrium(2)|large_intestine(9)|lung(10)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	31			OV - Ovarian serous cystadenocarcinoma(57;1.81e-09)			ACAGGTTTAGACACCCCAGTG	0.403000													28	113					0	0	1	0	0
CPAMD8	27151	broad.mit.edu	37	19	17036175	17036175	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:17036175G>A	ENST00000443236.1	-	26	3550	c.3519C>T	c.(3517-3519)gtC>gtT	p.V1173V		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1126						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						TTGGCCCCATGACGTCCCCTG	0.557000													15	25					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179664293	179664293	+	Silent	SNP	G	G	T	rs138060032		TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:179664293G>T	ENST00000589042.1	-	6	1059	c.835C>A	c.(835-837)Cgg>Agg	p.R279R	TTN_ENST00000360870.5_Silent_p.R279R|TTN_ENST00000460472.2_Silent_p.R279R|TTN_ENST00000359218.5_Silent_p.R279R|TTN_ENST00000342992.6_Silent_p.R279R|TTN_ENST00000591111.1_Silent_p.R279R|TTN_ENST00000342175.6_Silent_p.R279R	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	279	ZIS1.		R -> W (in HMERF; disrupts NBR1-binding).				ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GACTGCTGCCGAGCCAGCTGT	0.587000													17	58					1.67942e-08	1.91336e-08	1	1	0
BCORL1	63035	broad.mit.edu	37	X	129189975	129189975	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:129189975C>A	ENST00000540052.1	+	12	5044	c.5000C>A	c.(4999-5001)aCc>aAc	p.T1667N	BCORL1_ENST00000218147.7_Missense_Mutation_p.T1667N|BCORL1_ENST00000303743.5_Missense_Mutation_p.T1741N|BCORL1_ENST00000359304.2_Missense_Mutation_p.T1537N	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1667					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						CAGCTGCTGACCCCTGCCGAG	0.617000													10	150					2.52707e-12	3.08639e-12	1	1	0
ZNF267	10308	broad.mit.edu	37	16	31926778	31926778	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr16:31926778C>G	ENST00000300870.10	+	4	1417	c.1208C>G	c.(1207-1209)aCt>aGt	p.T403S	RP11-170L3.8_ENST00000575471.1_RNA	NM_001265588.1|NM_003414.5	NP_001252517.1|NP_003405.3	Q14586	ZN267_HUMAN	zinc finger protein 267	403					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(5)|kidney(1)|large_intestine(14)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	41						AGAATTCACACTGGAGAGAAA	0.368000													23	62					0	0	1	0	0
METTL7A	25840	broad.mit.edu	37	12	51318914	51318914	+	Silent	SNP	A	A	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:51318914A>T	ENST00000548553.1	+	2	1074	c.93A>T	c.(91-93)atA>atT	p.I31I	METTL7A_ENST00000332160.4_Silent_p.I31I			Q9H8H3	MET7A_HUMAN	methyltransferase like 7A	31						endoplasmic reticulum|lipid particle|membrane	methyltransferase activity			endometrium(1)|large_intestine(4)|lung(4)|upper_aerodigestive_tract(1)	10						GGAGCTGGATATGCAAAAAAT	0.468000													5	86					0	0	1	0	0
ANKRD34A	284615	broad.mit.edu	37	1	145473874	145473874	+	Silent	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:145473874G>T	ENST00000323397.4	+	4	1839	c.546G>T	c.(544-546)acG>acT	p.T182T		NM_001039888.2	NP_001034977.1	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34A	182										endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	20	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GGTTCTGCACGTCGCCTTCGG	0.617000													9	146					3.09899e-07	3.45337e-07	1	1	0
CACNA1E	777	broad.mit.edu	37	1	181705510	181705510	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:181705510G>A	ENST00000526775.1	+	21	3470	c.3305G>A	c.(3304-3306)cGt>cAt	p.R1102H	CACNA1E_ENST00000360108.3_Missense_Mutation_p.R1102H|CACNA1E_ENST00000367567.4_Missense_Mutation_p.R728H|CACNA1E_ENST00000367570.1_Missense_Mutation_p.R1121H|CACNA1E_ENST00000367573.2_Missense_Mutation_p.R1121H|CACNA1E_ENST00000357570.5_Missense_Mutation_p.R1072H|CACNA1E_ENST00000358338.5_Missense_Mutation_p.R1053H	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1121					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						aaggagaagCGTGAGACAGGC	0.547000													4	6					0	0	1	0	0
BLK	640	broad.mit.edu	37	8	11415514	11415514	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr8:11415514G>T	ENST00000259089.4	+	10	1588	c.996G>T	c.(994-996)ttG>ttT	p.L332F	RP11-148O21.4_ENST00000528629.1_RNA|BLK_ENST00000529894.1_Missense_Mutation_p.L261F	NM_001715.2	NP_001706.2	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	332	Protein kinase.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(4)|stomach(1)	27			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		GGAGCAGATTGTCACTCCCAA	0.557000													3	31					0.00024832	0.000260253	1	1	0
SLC35F4	341880	broad.mit.edu	37	14	58033204	58033204	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr14:58033204G>T	ENST00000556826.1	-	7	1441	c.1205C>A	c.(1204-1206)cCt>cAt	p.P402H	SLC35F4_ENST00000554729.1_Missense_Mutation_p.P279H|SLC35F4_ENST00000339762.6_Missense_Mutation_p.P438H	NM_001206920.1	NP_001193849.1			solute carrier family 35, member F4											breast(1)|endometrium(4)|large_intestine(3)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TGCATTTCCAGGAACGCTGAG	0.478000													3	5					1	1	1	1	0
ITGA4	3676	broad.mit.edu	37	2	182346392	182346392	+	Missense_Mutation	SNP	A	A	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:182346392A>T	ENST00000397033.2	+	7	1252	c.822A>T	c.(820-822)caA>caT	p.Q274H		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	274					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GAGCTCCTCAACATGAGCAGA	0.373000													12	26					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	33925194	33925194	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr15:33925194C>T	ENST00000389232.4	+	24	2982	c.2912C>T	c.(2911-2913)tCt>tTt	p.S971F	RYR3_ENST00000415757.3_Missense_Mutation_p.S971F	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	971	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TTGGATTTGTCTGATGTGAAG	0.378000													10	97					0	0	1	0	0
TMEM86A	144110	broad.mit.edu	37	11	18723358	18723358	+	Silent	SNP	A	A	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:18723358A>C	ENST00000280734.2	+	3	621	c.525A>C	c.(523-525)acA>acC	p.T175T		NM_153347.1	NP_699178.1	Q8N2M4	TM86A_HUMAN	transmembrane protein 86A	175						integral to membrane				endometrium(2)|kidney(1)|large_intestine(4)|lung(1)|ovary(1)|skin(2)	11						GGCGCTGGACAGAGCTGGCAG	0.597000													7	60					0	0	1	0	0
POMT2	29954	broad.mit.edu	37	14	77767499	77767499	+	Silent	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr14:77767499G>T	ENST00000261534.4	-	6	952	c.750C>A	c.(748-750)atC>atA	p.I250I		NM_013382.5	NP_037514.2	Q9UKY4	POMT2_HUMAN	protein-O-mannosyltransferase 2	250					protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			breast(2)|endometrium(2)|large_intestine(1)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	14			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0292)		CCACTTGAAGGATGATAAAGA	0.512000											OREG0022837	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	79					2.42023e-17	3.07054e-17	1	1	0
CETN2	1069	broad.mit.edu	37	X	151997126	151997126	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:151997126G>A	ENST00000370277.3	-	4	450	c.384C>T	c.(382-384)cgC>cgT	p.R128R	CETN2_ENST00000493482.1_5'UTR	NM_004344.1	NP_004335.1	P41208	CETN2_HUMAN	centrin, EF-hand protein, 2	128	EF-hand 3.				cell division|centriole replication|G2/M transition of mitotic cell cycle|mitosis|nucleotide-excision repair|regulation of cytokinesis	centriole|cytosol|XPC complex	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(1)|lung(4)|prostate(1)|skin(1)	7	Acute lymphoblastic leukemia(192;6.56e-05)					CCTTGGCCACGCGTTTCAGAT	0.423000								Direct reversal of damage;Nucleotide excision repair (NER)					30	86					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34884569	34884569	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:34884569C>G	ENST00000360581.1	+	7	947	c.819C>G	c.(817-819)atC>atG	p.I273M	NPSR1_ENST00000381542.1_Missense_Mutation_p.I207M|NPSR1_ENST00000531252.1_Missense_Mutation_p.I262M|NPSR1_ENST00000381539.3_Missense_Mutation_p.I273M|NPSR1_ENST00000359791.1_Missense_Mutation_p.I273M	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	273						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	TCAAGGCTATCAAGTATAGCA	0.438000													8	76					0	0	1	0	0
NOX1	27035	broad.mit.edu	37	X	100117726	100117726	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:100117726G>A	ENST00000372966.3	-	5	626	c.421C>T	c.(421-423)Ctc>Ttc	p.L141F	NOX1_ENST00000372964.1_Missense_Mutation_p.L141F|NOX1_ENST00000217885.5_Missense_Mutation_p.L141F|NOX1_ENST00000372960.4_Missense_Mutation_p.L104F	NM_007052.4|NM_013955.2	NP_008983.2|NP_039249.1	Q9Y5S8	NOX1_HUMAN	NADPH oxidase 1	141	Ferric oxidoreductase.				angiogenesis|cell migration|electron transport chain|FADH2 metabolic process|hydrogen peroxide metabolic process|inflammatory response|intracellular pH elevation|positive regulation of integrin biosynthetic process|positive regulation of smooth muscle cell proliferation|positive regulation vascular endothelial growth factor production|respiratory burst|response to pH|signal transduction|superoxide anion generation	cell junction|early endosome|invadopodium membrane|NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|Rac GTPase binding|superoxide-generating NADPH oxidase activity|voltage-gated proton channel activity			cervix(1)|lung(3)|ovary(1)|skin(2)	7						AGGCTGGAGAGAATGGAGGCA	0.463000													41	233					0	0	1	0	0
OR5W2	390148	broad.mit.edu	37	11	55681511	55681511	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:55681511G>C	ENST00000344514.1	-	1	547	c.548C>G	c.(547-549)cCt>cGt	p.P183R		NM_001001960.1	NP_001001960.1	Q8NH69	OR5W2_HUMAN	olfactory receptor, family 5, subfamily W, member 2	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(28)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						TAATAAGAGAGGAGGGATATC	0.408000													26	77					0	0	1	0	0
MRFAP1	93621	broad.mit.edu	37	4	6642857	6642857	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:6642857G>C	ENST00000320912.4	+	2	921	c.268G>C	c.(268-270)Gag>Cag	p.E90Q	MRFAP1_ENST00000382581.4_Missense_Mutation_p.E90Q|MRFAP1_ENST00000507420.1_Missense_Mutation_p.E90Q	NM_001272053.1	NP_001258982.1	Q9Y605	MOFA1_HUMAN	Morf4 family associated protein 1	90						nucleus|perinuclear region of cytoplasm	protein binding			lung(1)	1						CGACGCGGCCGAGGGCCGGGC	0.632000													31	67					0	0	1	0	0
CASC5	57082	broad.mit.edu	37	15	40916161	40916161	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr15:40916161C>T	ENST00000346991.5	+	11	4167	c.3777C>T	c.(3775-3777)ctC>ctT	p.L1259L	CASC5_ENST00000399668.2_Silent_p.L1233L			Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5	1259					acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		AGCAACAACTCTTTGCTGCTA	0.388000													8	59					0	0	1	0	0
C1orf226	400793	broad.mit.edu	37	1	162352997	162352997	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:162352997C>T	ENST00000458626.2	+	2	515	c.343C>T	c.(343-345)Cgg>Tgg	p.R115W	C1orf226_ENST00000426197.2_Missense_Mutation_p.R158W	NM_001085375.1	NP_001078844.1	A1L170	CA226_HUMAN	chromosome 1 open reading frame 226	115										central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	12						AACATTTCCTCGGCTGGATCC	0.512000													28	21					0	0	1	0	0
KMT2C	58508	broad.mit.edu	37	7	151945048	151945048	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:151945048C>A	ENST00000355193.2	-	14	2689	c.2471G>T	c.(2470-2472)gGc>gTc	p.G824V	KMT2C_ENST00000262189.6_Missense_Mutation_p.G824V					lysine (K)-specific methyltransferase 2C																		TTTACCCATGCCAATTTTTGG	0.408000													31	157					2.4375e-19	3.10104e-19	1	1	0
FLVCR1	28982	broad.mit.edu	37	1	213058634	213058634	+	Splice_Site	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:213058634G>A	ENST00000366971.4	+	5	1290		c.e5-1		FLVCR1_ENST00000483790.1_Splice_Site	NM_014053.3	NP_054772.1	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular receptor 1						cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(2)	12				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		ATTTTTTTCAGGGAGAAGAAG	0.363000													13	104					0	0	1	0	0
MAP4K1	11184	broad.mit.edu	37	19	39104543	39104543	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:39104543G>A	ENST00000591517.1	-	8	538	c.510C>T	c.(508-510)ctC>ctT	p.L170L	MAP4K1_ENST00000396857.2_Silent_p.L170L|MAP4K1_ENST00000589130.1_Silent_p.L166L|MAP4K1_ENST00000589002.1_5'UTR|MAP4K1_ENST00000423454.2_5'UTR|MAP4K1_ENST00000586296.1_Silent_p.L170L	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	170	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CAATGAAAGAGAGGCGTCTGG	0.622000													5	18					0	0	1	0	0
OR5T3	390154	broad.mit.edu	37	11	56019692	56019692	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:56019692C>A	ENST00000303059.3	+	1	17	c.17C>A	c.(16-18)aCa>aAa	p.T6K		NM_001004747.1	NP_001004747.1	Q8NGG3	OR5T3_HUMAN	olfactory receptor, family 5, subfamily T, member 3	6					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(23)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	39	Esophageal squamous(21;0.00448)					TCCACTTTCACAGGCTATAAC	0.363000													13	33					2.27111e-07	2.5432e-07	1	1	0
KDM5A	5927	broad.mit.edu	37	12	401983	401983	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:401983G>C	ENST00000399788.2	-	27	5170	c.4808C>G	c.(4807-4809)tCt>tGt	p.S1603C	KDM5A_ENST00000382815.4_Missense_Mutation_p.S1603C|KDM5A_ENST00000540838.1_5'UTR	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	1603					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						CTCATCATCAGACTCCTCTGC	0.478000			T	NUP98	AML								16	146					0	0	1	0	0
WNK4	65266	broad.mit.edu	37	17	40934882	40934882	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:40934882C>G	ENST00000246914.5	+	2	746	c.725C>G	c.(724-726)tCg>tGg	p.S242W		NM_032387.4	NP_115763.2	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	242	Protein kinase.				intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(3)|prostate(1)|skin(5)|stomach(1)	35		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		TCGTGGAAGTCGGTGCTGAGG	0.597000													12	56					0	0	1	0	0
ACTRT1	139741	broad.mit.edu	37	X	127185866	127185866	+	Missense_Mutation	SNP	A	A	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:127185866A>C	ENST00000371124.3	-	1	516	c.320T>G	c.(319-321)cTt>cGt	p.L107R		NM_138289.3	NP_612146.1	Q8TDG2	ACTT1_HUMAN	actin-related protein T1	107						cytoplasm|cytoskeleton				breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(13)|ovary(2)|skin(3)	34						CTCGGTCATAAGTACAGGCTG	0.463000													16	369					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43996140	43996140	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr22:43996140G>A	ENST00000262726.7	-	23	2938	c.2685C>T	c.(2683-2685)taC>taT	p.Y895Y	EFCAB6_ENST00000396231.2_Silent_p.Y743Y	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	895	EF-hand 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				CCTCGGTGTCGTATCTTAAAA	0.443000													17	159					0	0	1	0	0
KIF9	64147	broad.mit.edu	37	3	47286910	47286910	+	Splice_Site	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:47286910C>G	ENST00000335044.2	-	14	1738		c.e14+1		KIF9_ENST00000487440.1_Splice_Site|KIF9_ENST00000444589.2_Splice_Site|KIF9_ENST00000265529.3_Splice_Site|KIF9_ENST00000452770.2_Splice_Site|KIF9_ENST00000352910.4_Splice_Site|KIF9-AS1_ENST00000429315.3_RNA	NM_001134878.1|NM_182902.3	NP_001128350.1|NP_878905.2	Q9HAQ2	KIF9_HUMAN	kinesin family member 9						blood coagulation|microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(15)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)	34		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000284)|KIRC - Kidney renal clear cell carcinoma(197;0.00609)|Kidney(197;0.007)		ACTATGCTTACCTTCTGGATA	0.483000													37	102					0	0	1	0	0
USP54	159195	broad.mit.edu	37	10	75276726	75276726	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr10:75276726C>G	ENST00000339859.4	-	19	3558	c.3458G>C	c.(3457-3459)aGa>aCa	p.R1153T	USP54_ENST00000422491.2_Missense_Mutation_p.R335T|USP54_ENST00000497106.1_5'UTR|USP54_ENST00000394811.2_Missense_Mutation_p.R241T|USP54_ENST00000428547.1_Missense_Mutation_p.R1003T|USP54_ENST00000408019.1_Missense_Mutation_p.R1153T|RP11-137L10.6_ENST00000600206.1_RNA|RP11-137L10.6_ENST00000597958.1_RNA|RP11-137L10.6_ENST00000595069.1_RNA|RP11-137L10.6_ENST00000593790.1_RNA			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	1153					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					TGACAAACTTCTATCCTTGAA	0.507000													36	120					0	0	1	0	0
SERPINB4	6318	broad.mit.edu	37	18	61309036	61309036	+	Silent	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr18:61309036G>T	ENST00000341074.5	-	4	424	c.309C>A	c.(307-309)atC>atA	p.I103I	SERPINB4_ENST00000356424.6_Silent_p.I103I	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						GCTTGTTGGCGATCTTCAGCT	0.403000													38	149					6.29468e-14	7.74991e-14	1	1	0
ZNF208	7757	broad.mit.edu	37	19	22154277	22154277	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:22154277G>C	ENST00000397126.4	-	4	3707	c.3559C>G	c.(3559-3561)Cat>Gat	p.H1187D	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				ATTACCTTATGTTTTGCAAGG	0.363000													15	24					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19481451	19481451	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:19481451G>T	ENST00000375267.2	-	44	6422	c.6419C>A	c.(6418-6420)aCc>aAc	p.T2140N	UBR4_ENST00000375254.3_Missense_Mutation_p.T2140N|UBR4_ENST00000375217.2_Missense_Mutation_p.T2140N|UBR4_ENST00000375226.2_Missense_Mutation_p.T2140N			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	2140					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CACCTCCAGGGTTGTCCTGCT	0.493000													22	101					1.28384e-07	1.44117e-07	1	1	0
RPRD1B	58490	broad.mit.edu	37	20	36718247	36718247	+	Silent	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr20:36718247C>G	ENST00000373433.4	+	7	1353	c.951C>G	c.(949-951)ccC>ccG	p.P317P	RPRD1B_ENST00000471511.1_3'UTR	NM_021215.3	NP_067038.1	Q9NQG5	RPR1B_HUMAN	regulation of nuclear pre-mRNA domain containing 1B	317										endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)	12						CCCCCCTGCCCTCTGCTGGGG	0.527000													9	90					0	0	1	0	0
PRKCD	5580	broad.mit.edu	37	3	53219629	53219629	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:53219629C>T	ENST00000394729.2	+	10	1226	c.898C>T	c.(898-900)Cgg>Tgg	p.R300W	PRKCD_ENST00000330452.3_Missense_Mutation_p.R300W	NM_212539.1	NP_997704.1	Q05655	KPCD_HUMAN	protein kinase C, delta	300					activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		GAGAGCCTCCCGGAGATCAGA	0.577000													35	98					0	0	1	0	0
CHERP	10523	broad.mit.edu	37	19	16633941	16633941	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:16633941G>C	ENST00000546361.2	-	11	2053	c.1902C>G	c.(1900-1902)atC>atG	p.I634M	CHERP_ENST00000544299.1_5'UTR|CHERP_ENST00000198939.6_Missense_Mutation_p.I645M|CTD-3222D19.2_ENST00000409035.1_Intron	NM_006387.5	NP_006378.3	Q8IWX8	CHERP_HUMAN	calcium homeostasis endoplasmic reticulum protein	634	Pro-rich.				cellular calcium ion homeostasis|negative regulation of cell proliferation|nervous system development|RNA processing	endoplasmic reticulum|perinuclear region of cytoplasm	RNA binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(9)|ovary(2)|stomach(1)|urinary_tract(3)	24						CATCGTGGTTGATGTGGGGTG	0.672000													40	59					0	0	1	0	0
MYF5	4617	broad.mit.edu	37	12	81110965	81110965	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:81110965G>A	ENST00000228644.3	+	1	275	c.123G>A	c.(121-123)gcG>gcA	p.A41A		NM_005593.2	NP_005584.2	P13349	MYF5_HUMAN	myogenic factor 5	41					muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(8)|lung(15)|ovary(2)|pancreas(1)	30						CCTTCGGAGCGCACAAAGCAG	0.617000													3	32					0	0	1	0	0
EHMT2	10919	broad.mit.edu	37	6	31855628	31855628	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:31855628G>A	ENST00000395728.3	-	13	2026	c.2027C>T	c.(2026-2028)tCa>tTa	p.S676L	EHMT2_ENST00000375528.4_Missense_Mutation_p.S642L|EHMT2_ENST00000375537.4_Missense_Mutation_p.S619L|EHMT2_ENST00000375530.4_Missense_Mutation_p.S585L|EHMT2_ENST00000480912.1_5'UTR			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	619					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						CCCCACGGCTGAAAGGCAGCC	0.687000													34	82					0	0	1	0	0
PIK3CB	5291	broad.mit.edu	37	3	138376650	138376650	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:138376650G>C	ENST00000477593.1	-	21	2897	c.2824C>G	c.(2824-2826)Ctt>Gtt	p.L942V	PIK3CB_ENST00000544716.1_Missense_Mutation_p.L393V|PIK3CB_ENST00000289153.2_Missense_Mutation_p.L942V			P42338	PK3CB_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta	942	PI3K/PI4K.				activation of MAPK activity|chemotaxis|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell receptor signaling pathway	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	41						AAATTTCCAAGAATATGTCCA	0.353000													4	69					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10356507	10356507	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:10356507T>C	ENST00000255381.2	-	24	3183	c.3073A>G	c.(3073-3075)Acc>Gcc	p.T1025A	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1025					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TTAGCTTTGGTCAGGGTGTTG	0.463000													23	173					0	0	1	0	0
ZC3H4	23211	broad.mit.edu	37	19	47597252	47597252	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:47597252C>G	ENST00000253048.5	-	4	504	c.467G>C	c.(466-468)aGa>aCa	p.R156T	ZC3H4_ENST00000594019.1_5'UTR	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	156							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GCTGTACTCTCTGTACTTGCG	0.547000													11	95					0	0	1	0	0
PMFBP1	83449	broad.mit.edu	37	16	72162582	72162582	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr16:72162582G>T	ENST00000537465.1	-	14	2235	c.2077C>A	c.(2077-2079)Caa>Aaa	p.Q693K	PMFBP1_ENST00000237353.10_Missense_Mutation_p.Q688K|PMFBP1_ENST00000355636.6_Missense_Mutation_p.Q543K			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	693										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				TGGATGACTTGCTGGCTGGTG	0.458000													15	43					1.05317e-09	1.22736e-09	1	1	0
SLC9A3	6550	broad.mit.edu	37	5	484797	484797	+	Missense_Mutation	SNP	A	A	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr5:484797A>T	ENST00000264938.3	-	5	779	c.770T>A	c.(769-771)gTg>gAg	p.V257E	SLC9A3_ENST00000514375.1_Missense_Mutation_p.V257E	NM_004174.2	NP_004165.2	P48764	SL9A3_HUMAN	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3	257						cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CCCCAGGCTCACCACGAAGAA	0.677000													63	65					0	0	1	0	0
ESYT1	23344	broad.mit.edu	37	12	56531655	56531655	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:56531655G>A	ENST00000394048.5	+	19	2419	c.2155G>A	c.(2155-2157)Gaa>Aaa	p.E719K	ESYT1_ENST00000267113.4_Missense_Mutation_p.E729K|ESYT1_ENST00000541590.1_Missense_Mutation_p.E729K	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	719	C2 3.					integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						GCTAGAGGTTGAAGTCTTTGA	0.478000													9	140					0	0	1	0	0
ELOVL3	83401	broad.mit.edu	37	10	103988756	103988756	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr10:103988756T>C	ENST00000370005.3	+	4	781	c.560T>C	c.(559-561)cTg>cCg	p.L187P		NM_152310.1	NP_689523.1	Q9HB03	ELOV3_HUMAN	ELOVL fatty acid elongase 3	187					fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, polyunsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	fatty acid elongase activity|protein binding			breast(2)|lung(10)|ovary(2)|prostate(1)|skin(1)	16		Colorectal(252;0.207)		Epithelial(162;4.47e-08)|all cancers(201;7.96e-07)		TACTACACTCTGAAGGCTGCC	0.517000													27	68					0	0	1	0	0
DHX32	55760	broad.mit.edu	37	10	127569375	127569375	+	Nonsense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr10:127569375C>A	ENST00000284690.3	-	1	509	c.19G>T	c.(19-21)Gag>Tag	p.E7*	DHX32_ENST00000284688.6_Nonsense_Mutation_p.E7*	NM_018180.2	NP_060650.2	Q7L7V1	DHX32_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 32	7						mitochondrion|nucleus	ATP binding|helicase activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|stomach(1)	29		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TTTGGACACTCCAGCCCTTCT	0.473000													7	115					8.12818e-05	8.57767e-05	1	1	0
NAGS	162417	broad.mit.edu	37	17	42083067	42083067	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:42083067C>T	ENST00000293404.3	+	2	607	c.489C>T	c.(487-489)ttC>ttT	p.F163F		NM_153006.2	NP_694551.1	Q8N159	NAGS_HUMAN	N-acetylglutamate synthase	163					arginine biosynthetic process|urea cycle	mitochondrial matrix	acetyl-CoA:L-glutamate N-acetyltransferase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	8		Breast(137;0.00536)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)	L-Glutamic Acid(DB00142)	CCCTGGCCTTCTTGCAGCGCA	0.657000													3	19					0	0	1	0	0
PCF11	51585	broad.mit.edu	37	11	82880964	82880964	+	Missense_Mutation	SNP	A	A	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:82880964A>C	ENST00000298281.4	+	8	4039	c.3587A>C	c.(3586-3588)cAg>cCg	p.Q1196P		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	1196					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						AAAAATCTTCAGAGTTCTCAA	0.378000													3	10					0	0	1	0	0
AMPD3	272	broad.mit.edu	37	11	10500167	10500167	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:10500167A>G	ENST00000396554.3	+	3	684	c.343A>G	c.(343-345)Atg>Gtg	p.M115V	AMPD3_ENST00000444303.2_Intron	NM_000480.2	NP_000471.1	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3	106					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(3)|skin(1)	25				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		CAGTCCGGCCATGTCTCCCAC	0.582000													78	168					0	0	1	0	0
PCF11	51585	broad.mit.edu	37	11	82879653	82879653	+	Nonsense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:82879653C>A	ENST00000298281.4	+	8	2728	c.2276C>A	c.(2275-2277)tCa>tAa	p.S759*		NM_015885.3	NP_056969.2	O94913	PCF11_HUMAN	PCF11 cleavage and polyadenylation factor subunit	759	Gly-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				cervix(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(22)|ovary(1)|urinary_tract(1)	33						AGTAGGCCATCAGTAGCAAGA	0.463000													9	107					7.48243e-07	8.31785e-07	1	1	0
TUBA3E	112714	broad.mit.edu	37	2	130952782	130952782	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:130952782G>C	ENST00000312988.7	-	3	345	c.245C>G	c.(244-246)aCc>aGc	p.T82S		NM_207312.2	NP_997195.1	Q6PEY2	TBA3E_HUMAN	tubulin, alpha 3e	82					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			endometrium(4)|kidney(7)|large_intestine(6)|lung(9)|skin(2)	28	Colorectal(110;0.1)					CTGCCTGTAGGTCCCTGTGCG	0.502000													24	132					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11298523	11298523	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:11298523C>G	ENST00000361445.4	-	12	2014	c.1938G>C	c.(1936-1938)caG>caC	p.Q646H		NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	646					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						GCACTGCGGTCTGGCTAACCA	0.567000													5	95					0	0	1	0	0
SAP130	79595	broad.mit.edu	37	2	128712767	128712767	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:128712767C>G	ENST00000357702.5	-	16	2424	c.2293G>C	c.(2293-2295)Gca>Cca	p.A765P	SAP130_ENST00000259235.3_Missense_Mutation_p.A730P|SAP130_ENST00000259234.6_Missense_Mutation_p.A738P	NM_001145928.1	NP_001139400.1	Q9H0E3	SP130_HUMAN	Sin3A-associated protein, 130kDa	730	Pro-rich.				histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			NS(4)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	45	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0771)		GGACTGGCTGCTGCAATCATA	0.567000													11	107					0	0	1	0	0
C1ORF220	400798	broad.mit.edu	37	1	178514997	178514997	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:178514997C>G	ENST00000367636.4	+	2	721	c.383C>G	c.(382-384)tCt>tGt	p.S128C	C1orf220_ENST00000521244.1_3'UTR|C1orf220_ENST00000319387.2_3'UTR																							AAAATAAACTCTACAAACATC	0.448000													6	62					0	0	1	0	0
SCLY	51540	broad.mit.edu	37	2	238990700	238990700	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:238990700C>T	ENST00000254663.6	+	6	793	c.651C>T	c.(649-651)atC>atT	p.I217I	SCLY_ENST00000373332.3_Silent_p.I127I|SCLY_ENST00000555827.1_Silent_p.I209I|SCLY_ENST00000429612.2_Intron|SCLY_ENST00000409736.2_Silent_p.I209I|SCLY_ENST00000422984.2_Silent_p.I115I	NM_016510.5	NP_057594.4	Q96I15	SCLY_HUMAN	selenocysteine lyase	209					cellular amino acid metabolic process	cytosol	pyridoxal phosphate binding|selenocysteine lyase activity|transferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(6)|lung(5)|ovary(2)|prostate(2)|stomach(1)|urinary_tract(1)	22		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;1.37e-23)|OV - Ovarian serous cystadenocarcinoma(60;4.6e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;8.25e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000128)|Lung(119;0.0118)|LUSC - Lung squamous cell carcinoma(224;0.0285)		TCCCTGAAATCAGTCAGCGCA	0.557000													6	174					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577566	7577566	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:7577566T>C	ENST00000420246.2	-	7	847	c.715A>G	c.(715-717)Aac>Gac	p.N239D	TP53_ENST00000455263.2_Missense_Mutation_p.N239D|TP53_ENST00000445888.2_Missense_Mutation_p.N239D|TP53_ENST00000269305.4_Missense_Mutation_p.N239D|TP53_ENST00000413465.2_Missense_Mutation_p.N239D|TP53_ENST00000359597.4_Missense_Mutation_p.N239D	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	239	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).		N -> D (in sporadic cancers; somatic mutation).|N -> H (in a sporadic cancer; somatic mutation).|N -> I (in a sporadic cancer; somatic mutation).|N -> K (in sporadic cancers; somatic mutation).|N -> S (in sporadic cancers; somatic mutation).|N -> T (in sporadic cancers; somatic mutation).|N -> Y (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.N239D(33)|p.N239fs*25(12)|p.0?(8)|p.N239Y(6)|p.N239fs*1(5)|p.?(5)|p.M237_N239delMCN(4)|p.N239_C242delNSSC(3)|p.N239fs*8(2)|p.N239_S240delNS(2)|p.N239fs*26(1)|p.N146D(1)|p.N146fs*1(1)|p.Y236_M243delYMCNSSCM(1)|p.V225fs*23(1)|p.N239fs*6(1)|p.N239fs*4(1)|p.C238_N239insX(1)|p.C238_M246delCNSSCMGGM(1)|p.M144_N146delMCN(1)|p.C238fs*21(1)|p.H233fs*6(1)|p.N239*(1)|p.H233_C242del10(1)|p.N239_C242del(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGGAACTGTTACACATGTAG	0.572000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	26					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553181	140553181	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr5:140553181C>A	ENST00000231137.3	+	1	939	c.765C>A	c.(763-765)agC>agA	p.S255R		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		255	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCGAAAATAGCCCCGTTGGTT	0.507000													14	47					7.93312e-07	8.77625e-07	1	1	0
OSBPL6	114880	broad.mit.edu	37	2	179170975	179170975	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:179170975G>T	ENST00000190611.4	+	3	440	c.64G>T	c.(64-66)Gcc>Tcc	p.A22S	OSBPL6_ENST00000357080.4_Missense_Mutation_p.A22S|OSBPL6_ENST00000409045.3_Missense_Mutation_p.A22S|OSBPL6_ENST00000392505.2_Missense_Mutation_p.A22S|OSBPL6_ENST00000359685.3_Missense_Mutation_p.A22S|OSBPL6_ENST00000409631.1_Missense_Mutation_p.A22S	NM_032523.3	NP_115912.1	Q9BZF3	OSBL6_HUMAN	oxysterol binding protein-like 6	22					lipid transport		lipid binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(18)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00578)|Epithelial(96;0.00847)|all cancers(119;0.0335)			CCATAGAAGTGCCTCCTCTTC	0.453000													16	45					6.72482e-11	8.02075e-11	1	1	0
NIPBL	25836	broad.mit.edu	37	5	37048775	37048775	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr5:37048775A>G	ENST00000282516.8	+	39	7260	c.6761A>G	c.(6760-6762)gAc>gGc	p.D2254G	NIPBL_ENST00000448238.2_Missense_Mutation_p.D2254G	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	2254					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			GCAGATAGAGACTGTAAGTGA	0.284000													24	43					0	0	1	0	0
UGT1A3	54659	broad.mit.edu	37	2	234638105	234638105	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:234638105C>T	ENST00000482026.1	+	1	352	c.333C>T	c.(331-333)ttC>ttT	p.F111F	UGT1A6_ENST00000373424.1_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000480628.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A8_ENST00000373450.4_Intron	NM_019093.2	NP_061966.1														breast(2)|endometrium(7)|kidney(18)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	46		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;2.4e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000476)|Lung(119;0.00243)|LUSC - Lung squamous cell carcinoma(224;0.00599)		AGAAATTTTTCAGAAGTATGG	0.423000													49	136					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114277491	114277491	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:114277491G>A	ENST00000357077.4	+	38	7770	c.7717G>A	c.(7717-7719)Gat>Aat	p.D2573N	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.D2540N|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron|ANK2_ENST00000506722.1_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2540					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		AGAGGAGGATGATTCAGAAAA	0.413000													8	132					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64656819	64656819	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr14:64656819G>C	ENST00000357395.3	+	100	18201	c.7057G>C	c.(7057-7059)Gaa>Caa	p.E2353Q	SYNE2_ENST00000554584.1_Missense_Mutation_p.E5831Q|ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000394768.2_Missense_Mutation_p.E2353Q|SYNE2_ENST00000358025.3_Missense_Mutation_p.E5968Q|SYNE2_ENST00000344113.4_Missense_Mutation_p.E5968Q|SYNE2_ENST00000555002.1_Missense_Mutation_p.E2602Q			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	5968					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CTTGTTTAGTGAAAACAAGTT	0.418000													8	43					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117676688	117676688	+	Splice_Site	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:117676688G>C	ENST00000276204.6	+	2	177	c.102_splice	c.e2-1	p.E35_splice	DOCK11_ENST00000276202.7_Splice_Site_p.E35_splice			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	35					blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						TCTTATAAAGGAAAAGGCCAA	0.373000													5	97					0	0	1	0	0
DTX3L	151636	broad.mit.edu	37	3	122287753	122287753	+	Missense_Mutation	SNP	A	A	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:122287753A>C	ENST00000296161.4	+	3	1006	c.817A>C	c.(817-819)Aat>Cat	p.N273H	DTX3L_ENST00000383661.3_Intron	NM_138287.3	NP_612144.1	Q8TDB6	DTX3L_HUMAN	deltex 3-like (Drosophila)	273					histone monoubiquitination|response to DNA damage stimulus	cytoplasm|nucleus	histone binding|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(114;0.0459)		GAGTTCTCCAAATATGGTCTG	0.373000													18	53					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100729495	100729495	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr8:100729495G>T	ENST00000358544.2	+	37	6737	c.6626G>T	c.(6625-6627)tGt>tTt	p.C2209F	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.C2184F	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	2209					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GGACCATGTTGTGCTACTGCC	0.413000													7	105					0.0293803	0.0299027	1	1	0
C15orf53	400359	broad.mit.edu	37	15	38988835	38988835	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr15:38988835C>A	ENST00000318792.1	+	1	37	c.27C>A	c.(25-27)gaC>gaA	p.D9E		NM_207444.2	NP_997327.1	Q8NAA6	CO053_HUMAN	chromosome 15 open reading frame 53	9										endometrium(1)|large_intestine(1)|lung(2)|skin(1)|stomach(1)	6		all_cancers(109;1.75e-13)|all_epithelial(112;1.02e-11)|Lung NSC(122;1.9e-09)|all_lung(180;4.04e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;8.39e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0321)		CCCAAGAGGACCTGGGCATTT	0.552000													20	51					7.45023e-12	9.02699e-12	1	1	0
DCAF4L2	138009	broad.mit.edu	37	8	88885613	88885613	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr8:88885613G>A	ENST00000319675.3	-	1	683	c.587C>T	c.(586-588)gCg>gTg	p.A196V		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	196										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						AGAGTGATACGCGTGGATGCT	0.557000													43	107					0	0	1	0	0
FOLH1	2346	broad.mit.edu	37	11	49178291	49178291	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:49178291C>A	ENST00000340334.7	-	16	1924	c.1556G>T	c.(1555-1557)aGa>aTa	p.R519I	FOLH1_ENST00000343844.4_Missense_Mutation_p.R226I|FOLH1_ENST00000256999.2_Missense_Mutation_p.R534I|FOLH1_ENST00000533034.1_Missense_Mutation_p.R519I|FOLH1_ENST00000356696.3_Missense_Mutation_p.R534I	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	534	NAALADase.				proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	ATACCGTGCTCTGCCTGAAGC	0.308000													15	89					1.01871e-10	1.20873e-10	1	1	0
SPINK4	27290	broad.mit.edu	37	9	33248468	33248468	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr9:33248468G>A	ENST00000379725.1	+	5	451	c.329G>A	c.(328-330)tGa>tAa	p.*110*	SPINK4_ENST00000379721.3_Silent_p.*87*|SPINK4_ENST00000379723.1_Silent_p.*110*			O60575	ISK4_HUMAN	serine peptidase inhibitor, Kazal type 4	0						extracellular region	serine-type endopeptidase inhibitor activity			lung(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)			GGCAAATGCTGATCCCACAGG	0.473000													9	11					0	0	1	0	0
OPRM1	4988	broad.mit.edu	37	6	154412219	154412219	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:154412219T>C	ENST00000414028.2	+	3	826	c.776T>C	c.(775-777)tTg>tCg	p.L259S	OPRM1_ENST00000428397.2_Missense_Mutation_p.L259S|OPRM1_ENST00000435918.2_Missense_Mutation_p.L259S|OPRM1_ENST00000522555.1_Missense_Mutation_p.L159S|OPRM1_ENST00000419506.2_Missense_Mutation_p.L259S|OPRM1_ENST00000229768.5_Missense_Mutation_p.L259S|OPRM1_ENST00000360422.4_Missense_Mutation_p.L259S|OPRM1_ENST00000452687.2_Missense_Mutation_p.L259S|OPRM1_ENST00000520708.1_Missense_Mutation_p.L159S|OPRM1_ENST00000330432.7_Missense_Mutation_p.L259S|OPRM1_ENST00000337049.4_Missense_Mutation_p.L259S|OPRM1_ENST00000518759.1_Missense_Mutation_p.L178S|OPRM1_ENST00000522236.1_Missense_Mutation_p.L159S|OPRM1_ENST00000434900.2_Missense_Mutation_p.L352S|OPRM1_ENST00000524163.1_Missense_Mutation_p.L259S	NM_001145284.2	NP_001138756.1	P35372	OPRM_HUMAN	opioid receptor, mu 1	259					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(15)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	33		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	CTGATGATCTTGCGCCTCAAG	0.502000													35	80					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35619537	35619537	+	Splice_Site	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr13:35619537C>T	ENST00000400445.3	+	4	1256	c.723_splice	c.e4+1	p.A241_splice	NBEA_ENST00000310336.4_Splice_Site_p.A241_splice|NBEA_ENST00000540320.1_Splice_Site_p.A241_splice|NBEA_ENST00000379939.2_Splice_Site_p.A241_splice	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	241						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGTAGCGCTGCGGTAAGTTTT	0.333000													12	4					0	0	1	0	0
CMAS	55907	broad.mit.edu	37	12	22211632	22211632	+	Nonsense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:22211632C>T	ENST00000229329.2	+	4	821	c.691C>T	c.(691-693)Cag>Tag	p.Q231*		NM_018686.4	NP_061156.1	Q8NFW8	NEUA_HUMAN	cytidine monophosphate N-acetylneuraminic acid synthetase	231					lipopolysaccharide biosynthetic process	nucleus	N-acylneuraminate cytidylyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(6)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	24						GGGTTACTTGCAGGTTTGTAC	0.368000													23	67					0	0	1	0	0
RPS6KA1	6195	broad.mit.edu	37	1	26882043	26882043	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:26882043G>A	ENST00000374168.2	+	11	997	c.843G>A	c.(841-843)atG>atA	p.M281I	RPS6KA1_ENST00000488985.1_3'UTR|RPS6KA1_ENST00000530003.1_Missense_Mutation_p.M265I|RPS6KA1_ENST00000531382.1_Missense_Mutation_p.M290I|RPS6KA1_ENST00000526792.1_Missense_Mutation_p.M189I|RPS6KA1_ENST00000374162.2_Missense_Mutation_p.M189I|RPS6KA1_ENST00000374166.4_Missense_Mutation_p.M270I	NM_002953.3	NP_002944.2	Q15418	KS6A1_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 1	281	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein binding|protein serine/threonine kinase activity			lung(1)	1		all_cancers(24;2.49e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00571)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.12e-50)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-29)|Colorectal(126;1.4e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000537)|KIRC - Kidney renal clear cell carcinoma(1967;0.000759)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0361)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.161)|LUSC - Lung squamous cell carcinoma(448;0.234)		AGCTAGGCATGCCCCAGTTTC	0.652000													3	6					0	0	1	0	0
FAM98A	25940	broad.mit.edu	37	2	33812314	33812314	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:33812314G>C	ENST00000403368.1	-	5	665	c.596C>G	c.(595-597)gCc>gGc	p.A199G	FAM98A_ENST00000441530.2_Missense_Mutation_p.A4G|FAM98A_ENST00000498340.1_5'UTR|FAM98A_ENST00000238823.8_Missense_Mutation_p.A199G	NM_015475.3	NP_056290.3	Q8NCA5	FA98A_HUMAN	family with sequence similarity 98, member A	200										NS(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(1)	24	all_hematologic(175;0.115)					CACCCAGTGGGCTGGTCCCAT	0.333000													39	92					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14513764	14513764	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr18:14513764C>T	ENST00000358970.5	-	10	1429	c.1430G>A	c.(1429-1431)cGg>cAg	p.R477Q		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	477								p.R477Q(12)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						AAGTTGTTTCCGGGTATCATT	0.358000													4	61					0	0	1	0	0
FAM47B	170062	broad.mit.edu	37	X	34961849	34961849	+	Nonsense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:34961849G>T	ENST00000329357.5	+	1	937	c.901G>T	c.(901-903)Gag>Tag	p.E301*		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	301	Pro-rich.									breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						GGAGCCTCCTGAGACTGGAGT	0.637000													20	58					7.45023e-12	9.02699e-12	1	1	0
C9orf152	401546	broad.mit.edu	37	9	112969802	112969802	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr9:112969802G>A	ENST00000400613.4	-	1	667	c.58C>T	c.(58-60)Cac>Tac	p.H20Y		NM_001012993.2	NP_001013011.2	Q5JTZ5	CI152_HUMAN	chromosome 9 open reading frame 152	20										NS(1)|endometrium(1)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						GCCATTAAGTGAGACCTAAGC	0.627000													3	39					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3240149	3240149	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:3240149A>G	ENST00000217939.6	-	5	3731	c.3577T>C	c.(3577-3579)Tca>Cca	p.S1193P		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1193						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ACTTGACTTGAAATCTTAATG	0.463000													13	104					0	0	1	0	0
FMO4	2329	broad.mit.edu	37	1	171293331	171293331	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:171293331G>C	ENST00000367749.3	+	5	706	c.376G>C	c.(376-378)Gat>Cat	p.D126H	FMO4_ENST00000462992.1_3'UTR	NM_002022.1	NP_002013.1	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	126					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	33	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TGGTCAGTGGGATGTTGTCAC	0.463000													30	506					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55889872	55889872	+	Silent	SNP	A	A	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:55889872A>T	ENST00000313472.3	+	1	24	c.24A>T	c.(22-24)acA>acT	p.T8T		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	8					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					GGAATGACACAAATGTGGCTG	0.463000													25	123					0	0	1	0	0
CLCN1	1180	broad.mit.edu	37	7	143049057	143049057	+	Nonstop_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:143049057G>C	ENST00000343257.2	+	23	3053	c.2966G>C	c.(2965-2967)tGa>tCa	p.*989S		NM_000083.2	NP_000074.2	P35523	CLCN1_HUMAN	chloride channel, voltage-sensitive 1	0					muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			breast(4)|central_nervous_system(1)|endometrium(1)|large_intestine(11)|lung(26)|ovary(3)|prostate(2)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	58	Melanoma(164;0.205)					CTGATCCTTTGACCCCCTCCC	0.617000													16	66					0	0	1	0	0
BCAN	63827	broad.mit.edu	37	1	156618475	156618475	+	Missense_Mutation	SNP	T	T	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:156618475T>G	ENST00000329117.4	+	6	1221	c.885T>G	c.(883-885)gaT>gaG	p.D295E	RP11-284F21.7_ENST00000448869.1_RNA|BCAN_ENST00000361588.5_Missense_Mutation_p.D295E	NM_021948.4	NP_068767.3	Q96GW7	PGCB_HUMAN	brevican	295	Link 2.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	55	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CAGCCTGGGATGGTGGCCTGG	0.647000													21	146					0	0	1	0	0
BUD13	84811	broad.mit.edu	37	11	116629059	116629059	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:116629059G>A	ENST00000260210.4	-	7	1448	c.1425C>T	c.(1423-1425)ctC>ctT	p.L475L	BUD13_ENST00000375445.3_Silent_p.L341L	NM_032725.3	NP_116114.1	Q9BRD0	BUD13_HUMAN	BUD13 homolog (S. cerevisiae)	475										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|pancreas(2)|skin(1)|urinary_tract(1)	22	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		CTAAACGTTCGAGTTTCAAAT	0.413000													46	136					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129826416	129826416	+	Silent	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:129826416C>A	ENST00000421865.2	+	61	8668	c.8619C>A	c.(8617-8619)ccC>ccA	p.P2873P		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2873	Laminin G-like 4.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CCATCAGTCCCAAAAAAGCCG	0.408000													22	65					6.21321e-17	7.86091e-17	1	1	0
DECR1	1666	broad.mit.edu	37	8	91057173	91057173	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr8:91057173A>G	ENST00000522161.1	+	10	1491	c.808A>G	c.(808-810)Aat>Gat	p.N270D	DECR1_ENST00000220764.2_Missense_Mutation_p.N279D			Q16698	DECR_HUMAN	2,4-dienoyl CoA reductase 1, mitochondrial	279					fatty acid beta-oxidation|protein homotetramerization	mitochondrial matrix|nucleus|plasma membrane	2,4-dienoyl-CoA reductase (NADPH) activity|NADPH binding|oxidoreductase activity, acting on NADH or NADPH			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	15			BRCA - Breast invasive adenocarcinoma(11;0.00953)			AGAACTCGCAAATCTTGCTGC	0.438000													48	78					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114282484	114282484	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:114282484G>C	ENST00000393500.3	+	13	1390	c.570G>C	c.(568-570)gaG>gaC	p.E190D	FOXP2_ENST00000393494.2_Missense_Mutation_p.E265D|FOXP2_ENST00000393491.3_Missense_Mutation_p.E173D|FOXP2_ENST00000360232.4_Missense_Mutation_p.E265D|FOXP2_ENST00000393498.2_Missense_Mutation_p.E244D|FOXP2_ENST00000393489.3_Missense_Mutation_p.E173D|FOXP2_ENST00000350908.4_Missense_Mutation_p.E265D|FOXP2_ENST00000378237.3_Missense_Mutation_p.E265D|FOXP2_ENST00000408937.3_Missense_Mutation_p.E290D|FOXP2_ENST00000390668.3_Missense_Mutation_p.E289D|FOXP2_ENST00000403559.4_Missense_Mutation_p.E282D			O15409	FOXP2_HUMAN	forkhead box P2	265	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						GTCCTGCTGAGATTCAGCAGT	0.373000													7	50					0	0	1	0	0
ZMYM1	79830	broad.mit.edu	37	1	35580515	35580515	+	Missense_Mutation	SNP	A	A	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:35580515A>C	ENST00000373330.1	+	11	3258	c.3084A>C	c.(3082-3084)agA>agC	p.R1028S	ZMYM1_ENST00000373329.1_3'UTR|ZMYM1_ENST00000359858.4_Missense_Mutation_p.R1028S			Q5SVZ6	ZMYM1_HUMAN	zinc finger, MYM-type 1	1028						nucleus	nucleic acid binding|protein dimerization activity|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(5)|lung(8)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	31		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CAGAACTTAGATTTTATCGAC	0.333000													7	119					0	0	1	0	0
MASP1	5648	broad.mit.edu	37	3	186954337	186954337	+	Missense_Mutation	SNP	C	C	T	rs141872329	byFrequency	TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:186954337C>T	ENST00000296280.6	-	11	1547	c.1322G>A	c.(1321-1323)cGc>cAc	p.R441H	MASP1_ENST00000392472.2_Missense_Mutation_p.R328H|MASP1_ENST00000337774.5_Intron|MASP1_ENST00000495249.1_Intron	NM_139125.3	NP_624302.1	P48740	MASP1_HUMAN	mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)	441					complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(2)|lung(27)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	60	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		TGGCAGGGAGCGGGAGGGCTG	0.572000													40	127					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123283358	123283358	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:123283358C>G	ENST00000264501.4	+	86	15347	c.14974C>G	c.(14974-14976)Cag>Gag	p.Q4992E	KIAA1109_ENST00000388738.3_Missense_Mutation_p.Q4992E			Q2LD37	K1109_HUMAN	KIAA1109	4992					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TACTGCACTACAGGATGAAAA	0.373000													10	120					0	0	1	0	0
SYDE2	84144	broad.mit.edu	37	1	85647996	85647996	+	Nonsense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:85647996G>A	ENST00000341460.5	-	3	2378	c.2329C>T	c.(2329-2331)Cag>Tag	p.Q777*		NM_032184.1	NP_115560.1	Q5VT97	SYDE2_HUMAN	synapse defective 1, Rho GTPase, homolog 2 (C. elegans)	777	C2.				activation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	Rho GTPase activator activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(1)	20				all cancers(265;0.0126)|Epithelial(280;0.0336)		ACAGCCAACTGATGAGTCTTT	0.388000													11	25					0	0	1	0	0
WBP11	51729	broad.mit.edu	37	12	14947650	14947650	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:14947650G>C	ENST00000261167.2	-	7	775	c.542C>G	c.(541-543)tCt>tGt	p.S181C	WBP11_ENST00000537574.1_Missense_Mutation_p.S181C	NM_016312.2	NP_057396.1	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	181	Pro-rich.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)	30						AGGAAGGATAGAAACTGCCCG	0.448000													8	82					0	0	1	0	0
HPS5	11234	broad.mit.edu	37	11	18339331	18339331	+	Silent	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:18339331G>C	ENST00000349215.3	-	2	352	c.75C>G	c.(73-75)ctC>ctG	p.L25L	HPS5_ENST00000396253.3_Intron|HPS5_ENST00000438420.2_Intron|HPS5_ENST00000531848.1_Intron	NM_181507.1	NP_852608.1	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5	25						cytosol				breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30						GCAGGGCTGAGAGTAATGGAT	0.468000									Hermansky-Pudlak syndrome				3	29					0	0	1	0	0
ABCC9	10060	broad.mit.edu	37	12	22025600	22025600	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:22025600G>A	ENST00000261200.4	-	16	2156	c.2157C>T	c.(2155-2157)ctC>ctT	p.L719L	ABCC9_ENST00000261201.4_Silent_p.L719L|ABCC9_ENST00000345162.2_Silent_p.L683L|RP11-729I10.2_ENST00000539874.1_RNA	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	719	ABC transporter 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GCATCTCACCGAGGATGGCAA	0.423000													17	109					0	0	1	0	0
PPP1R12C	54776	broad.mit.edu	37	19	55605780	55605780	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:55605780T>C	ENST00000263433.3	-	13	1631	c.1616A>G	c.(1615-1617)gAt>gGt	p.D539G	PPP1R12C_ENST00000376393.2_Missense_Mutation_p.D539G|PPP1R12C_ENST00000435544.2_Missense_Mutation_p.D465G	NM_001271618.1|NM_017607.2	NP_001258547.1|NP_060077.1	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	539						cytoplasm				central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	22			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		CGACTCCTCATCCCGCACAGG	0.637000													26	37					0	0	1	0	0
CDON	50937	broad.mit.edu	37	11	125888241	125888241	+	Silent	SNP	T	T	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:125888241T>G	ENST00000392693.3	-	5	751	c.624A>C	c.(622-624)cgA>cgC	p.R208R	CDON_ENST00000263577.7_Silent_p.R208R	NM_001243597.1|NM_016952.4	NP_001230526.1|NP_058648.4	Q4KMG0	CDON_HUMAN	cell adhesion associated, oncogene regulated	208					cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(9)|ovary(3)|prostate(2)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	61	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		CAAGGAGCTTTCGGCCAATAG	0.363000													7	153					0	0	1	0	0
SBF2	81846	broad.mit.edu	37	11	9875094	9875094	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:9875094C>G	ENST00000256190.8	-	20	2666	c.2529G>C	c.(2527-2529)atG>atC	p.M843I	RP11-1H15.2_ENST00000533659.1_RNA	NM_030962.3	NP_112224.1	Q86WG5	MTMRD_HUMAN	SET binding factor 2	843					myelination	cytoplasm|membrane	phosphatase activity|protein binding			breast(4)|endometrium(8)|kidney(2)|large_intestine(8)|lung(16)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48				all cancers(16;2.88e-11)|Epithelial(150;3.61e-10)|BRCA - Breast invasive adenocarcinoma(625;0.00887)		TACCTGGTATCATGCAATGAA	0.378000													23	106					0	0	1	0	0
DDX39B	7919	broad.mit.edu	37	6	31503116	31503116	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:31503116G>C	ENST00000453105.2	-	5	808	c.622C>G	c.(622-624)Cca>Gca	p.P208A	DDX39B_ENST00000415382.2_Intron|DDX39B_ENST00000396172.1_Intron|DDX39B_ENST00000376177.2_Intron|DDX39B_ENST00000417556.2_Intron|ATP6V1G2-DDX39B_ENST00000376185.1_Intron|DDX39B_ENST00000458640.1_Intron			Q13838	DX39B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	0	Helicase ATP-binding.				intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						gcggggagtggagggagagaa	0.547000													5	58					0	0	1	0	0
ZNF438	220929	broad.mit.edu	37	10	31137626	31137626	+	Nonsense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr10:31137626C>A	ENST00000538351.1	-	7	2315	c.1561G>T	c.(1561-1563)Gag>Tag	p.E521*	ZNF438_ENST00000444692.2_Nonsense_Mutation_p.E560*|ZNF438_ENST00000375311.1_Nonsense_Mutation_p.E134*|ZNF438_ENST00000413025.1_Nonsense_Mutation_p.E570*|ZNF438_ENST00000331737.6_Nonsense_Mutation_p.E560*|ZNF438_ENST00000452305.1_Nonsense_Mutation_p.E560*|ZNF438_ENST00000442986.1_Nonsense_Mutation_p.E570*|ZNF438_ENST00000436087.2_Nonsense_Mutation_p.E570*|ZNF438_ENST00000361310.3_Nonsense_Mutation_p.E570*	NM_001143769.1	NP_001137241.1	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438	570					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(15)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(175;0.0587)				GCACAAAACTCACAACACATG	0.478000													45	86					8.01111e-26	1.03355e-25	1	1	0
CCDC172	374355	broad.mit.edu	37	10	118084852	118084852	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr10:118084852G>A	ENST00000333254.3	+	3	368	c.117G>A	c.(115-117)aaG>aaA	p.K39K	CCDC172_ENST00000497093.1_3'UTR	NM_198515.2	NP_940917.1			coiled-coil domain containing 172																		AAAAAATTAAGAAAGCAACGG	0.338000													4	26					0	0	1	0	0
PCNXL3	399909	broad.mit.edu	37	11	65403712	65403712	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:65403712G>T	ENST00000355703.3	+	33	6066	c.5527G>T	c.(5527-5529)Ggc>Tgc	p.G1843C		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1843	Gly-rich.					integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CTGTAGTGGGGGCGGTGGCCT	0.637000													6	5					0.0215528	0.0219848	1	1	0
KIF15	56992	broad.mit.edu	37	3	44882588	44882588	+	Missense_Mutation	SNP	T	T	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:44882588T>A	ENST00000326047.4	+	29	3592	c.3443T>A	c.(3442-3444)tTt>tAt	p.F1148Y	KIF15_ENST00000425755.1_Missense_Mutation_p.F783Y	NM_020242.2	NP_064627.1	Q9NS87	KIF15_HUMAN	kinesin family member 15	1148					blood coagulation|cell proliferation|microtubule-based movement|mitosis	centrosome|cytosol|microtubule|plus-end kinesin complex|spindle	ATP binding|DNA binding|microtubule motor activity			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|liver(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(5)	36				BRCA - Breast invasive adenocarcinoma(193;0.0099)|KIRC - Kidney renal clear cell carcinoma(197;0.0564)|Kidney(197;0.0707)		CCACCTCACTTTCAAACACAT	0.333000													11	36					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41306759	41306759	+	Silent	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr20:41306759C>A	ENST00000373198.3	-	7	1135	c.900G>T	c.(898-900)gtG>gtT	p.V300V	PTPRT_ENST00000373193.3_Silent_p.V300V|PTPRT_ENST00000373201.1_Silent_p.V300V|PTPRT_ENST00000373184.1_Silent_p.V300V|PTPRT_ENST00000356100.2_Silent_p.V300V|PTPRT_ENST00000373187.1_Silent_p.V300V|PTPRT_ENST00000373190.1_Silent_p.V300V	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	300	Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ATGTGGCCCCCACAGCCAGCA	0.527000													8	37					1.06961e-07	1.20364e-07	1	1	0
ARMCX2	9823	broad.mit.edu	37	X	100912526	100912526	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:100912526C>G	ENST00000328766.5	-	5	502	c.49G>C	c.(49-51)Ggg>Cgg	p.G17R	ARMCX2_ENST00000330154.2_Missense_Mutation_p.G17R|ARMCX2_ENST00000467416.1_5'UTR|ARMCX2_ENST00000356824.4_Missense_Mutation_p.G17R	NM_014782.5	NP_055597.1	Q7L311	ARMX2_HUMAN	armadillo repeat containing, X-linked 2	17						integral to membrane	binding			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(6)|prostate(1)|skin(1)	29						GCACCAGCCCCTATCACTATC	0.577000													9	75					0	0	1	0	0
MTOR	2475	broad.mit.edu	37	1	11303213	11303213	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:11303213T>C	ENST00000361445.4	-	9	1446	c.1370A>G	c.(1369-1371)gAc>gGc	p.D457G		NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	457				VLD -> GVE (in Ref. 2; AAC39933).	cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						TCGGATGATGTCCAGCACGCG	0.542000													30	87					0	0	1	0	0
MID2	11043	broad.mit.edu	37	X	107084259	107084259	+	Silent	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:107084259C>A	ENST00000262843.6	+	2	912	c.364C>A	c.(364-366)Cgg>Agg	p.R122R	MID2_ENST00000443968.2_Silent_p.R122R	NM_012216.3|NM_052817.2	NP_036348.2|NP_438112.2	Q9UJV3	TRIM1_HUMAN	midline 2	122						centrosome|microtubule	ligase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)	19						TGAGAGCCGCCGGGAAAGGAC	0.542000													7	53					0.248553	0.250191	1	1	0
INSL3	3640	broad.mit.edu	37	19	17927841	17927841	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:17927841C>T	ENST00000379695.5	-	3	380	c.313G>A	c.(313-315)Gac>Aac	p.D105N	INSL3_ENST00000317306.7_Missense_Mutation_p.R73Q	NM_001265587.1	NP_001252516.1	P51460	INSL3_HUMAN	insulin-like 3 (Leydig cell)	0					cell-cell signaling|spermatogenesis	soluble fraction	hormone activity|insulin receptor binding|signal transducer activity			breast(1)|lung(1)	2						GAGCAGATGTCGTCTCTCCAG	0.602000													9	11					0	0	1	0	0
ELF2	1998	broad.mit.edu	37	4	139993119	139993119	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:139993119C>G	ENST00000394235.2	-	6	893	c.391G>C	c.(391-393)Gaa>Caa	p.E131Q	ELF2_ENST00000358635.3_Missense_Mutation_p.E83Q|ELF2_ENST00000379550.1_Missense_Mutation_p.E143Q|ELF2_ENST00000379549.2_Missense_Mutation_p.E83Q|ELF2_ENST00000510408.1_Missense_Mutation_p.E71Q|ELF2_ENST00000265495.4_Missense_Mutation_p.E131Q	NM_001276458.1	NP_001263387.1	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription factor)	143					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	19	all_hematologic(180;0.162)					ACTACAGTTTCTGTAATGACA	0.388000													24	87					0	0	1	0	0
OR2T1	26696	broad.mit.edu	37	1	248569329	248569329	+	Missense_Mutation	SNP	T	T	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:248569329T>G	ENST00000366474.1	+	1	34	c.34T>G	c.(34-36)Ttc>Gtc	p.F12V		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AAATGTTTTCTTCCCACTTTT	0.289000													9	97					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219886515	219886515	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:219886515G>T	ENST00000341552.5	-	18	3200	c.3117C>A	c.(3115-3117)gaC>gaA	p.D1039E	CCDC108_ENST00000453220.1_Missense_Mutation_p.D1039E|CCDC108_ENST00000441968.1_Missense_Mutation_p.D1039E	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1039						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGGGGTGGTTGTCAACGGCCT	0.612000													41	138					1.59361e-14	1.97797e-14	1	1	0
TSPYL4	23270	broad.mit.edu	37	6	116574353	116574353	+	Silent	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:116574353T>C	ENST00000420283.1	-	1	908	c.819A>G	c.(817-819)gaA>gaG	p.E273E		NM_021648.4	NP_067680.3	Q9UJ04	TSYL4_HUMAN	TSPY-like 4	273					nucleosome assembly	nucleus				endometrium(2)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(2)	11		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.045)|OV - Ovarian serous cystadenocarcinoma(136;0.0666)|GBM - Glioblastoma multiforme(226;0.095)|Epithelial(106;0.125)		TCAGCATGTCTTCATCTTGGC	0.488000													6	41					0	0	1	0	0
HDAC6	10013	broad.mit.edu	37	X	48681203	48681203	+	Splice_Site	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:48681203G>T	ENST00000334136.5	+	24	2689	c.2512_splice	c.e24+1	p.M837_splice	HDAC6_ENST00000376619.2_Splice_Site_p.M837_splice|HDAC6_ENST00000444343.2_Splice_Site_p.M851_splice			Q9UBN7	HDAC6_HUMAN	histone deacetylase 6	837					aggresome assembly|cellular response to hydrogen peroxide|Hsp90 deacetylation|lysosome localization|macroautophagy|misfolded or incompletely synthesized protein catabolic process|negative regulation of proteolysis|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|polyubiquitinated misfolded protein transport|positive regulation of apoptosis|positive regulation of cellular chaperone-mediated protein complex assembly|positive regulation of epithelial cell migration|positive regulation of receptor biosynthetic process|positive regulation of signal transduction|regulation of androgen receptor signaling pathway|regulation of receptor activity|response to growth factor stimulus|response to toxin|transcription, DNA-dependent|tubulin deacetylation	aggresome|caveola|cell leading edge|cytosol|histone deacetylase complex|microtubule associated complex|perinuclear region of cytoplasm	actin binding|alpha-tubulin binding|beta-catenin binding|dynein complex binding|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|Hsp90 protein binding|microtubule binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|polyubiquitin binding|tau protein binding|tubulin deacetylase activity|zinc ion binding			breast(2)|endometrium(6)|kidney(5)|large_intestine(8)|lung(9)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	40					Vorinostat(DB02546)	TACGGGTCATGAGTGAGTGGA	0.612000													4	21					1.23904e-05	1.3384e-05	1	1	0
NCOR1	9611	broad.mit.edu	37	17	16075263	16075263	+	Missense_Mutation	SNP	A	A	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:16075263A>T	ENST00000268712.3	-	4	546	c.289T>A	c.(289-291)Tcc>Acc	p.S97T	NCOR1_ENST00000395851.1_Missense_Mutation_p.S97T|NCOR1_ENST00000395848.1_Intron	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	97	Interaction with ZBTB33 and HEXIM1.				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		TCCACTGGGGATGGGCCTGGA	0.423000													3	30					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	142012211	142012211	+	Splice_Site	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:142012211C>T	ENST00000389484.3	-	4	1315		c.e4-1			NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GATAACAGTTCTGTAGAGAAA	0.308000										TSP Lung(27;0.18)			10	36					0	0	1	0	0
IL4I1	259307	broad.mit.edu	37	19	50399205	50399205	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:50399205G>T	ENST00000595948.1	-	5	805	c.185C>A	c.(184-186)cCt>cAt	p.P62H	IL4I1_ENST00000391826.2_Missense_Mutation_p.P40H|IL4I1_ENST00000341114.3_Missense_Mutation_p.P62H	NM_001258018.1	NP_001244947.1	Q96RQ9	OXLA_HUMAN	interleukin 4 induced 1	40						lysosome	L-amino-acid oxidase activity			endometrium(3)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	16		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00245)|OV - Ovarian serous cystadenocarcinoma(262;0.0169)		CTCATAGTCAGGATCCTGCAT	0.627000													35	66					9.78485e-24	1.2518e-23	1	1	0
TAF3	83860	broad.mit.edu	37	10	8007307	8007307	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr10:8007307G>C	ENST00000344293.5	+	3	2040	c.1834G>C	c.(1834-1836)Gag>Cag	p.E612Q		NM_031923.3	NP_114129.1	Q5VWG9	TAF3_HUMAN	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa	612	Lys-rich.				maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			NS(2)|breast(4)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(3)|prostate(4)|skin(2)	40						TGTGAGGAAGGAGAAAGAGAA	0.338000													8	49					0	0	1	0	0
TMPRSS11F	389208	broad.mit.edu	37	4	68919627	68919627	+	Nonstop_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:68919627C>G	ENST00000356291.2	-	10	1376	c.1317G>C	c.(1315-1317)taG>taC	p.*439Y	RP11-453E17.1_ENST00000500538.2_RNA	NM_207407.2	NP_997290.2	Q6ZWK6	TM11F_HUMAN	transmembrane protease, serine 11F	0					proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(4)	39						GCAATCCACACTACATACCAG	0.398000													11	64					0	0	1	0	0
SHCBP1L	81626	broad.mit.edu	37	1	182873351	182873351	+	Silent	SNP	A	A	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:182873351A>T	ENST00000367547.3	-	8	1787	c.1551T>A	c.(1549-1551)gcT>gcA	p.A517A	SHCBP1L_ENST00000423786.1_Silent_p.A398A|SHCBP1L_ENST00000488956.1_5'UTR	NM_030933.2	NP_112195.2	Q9BZQ2	SHP1L_HUMAN	SHC SH2-domain binding protein 1-like	589										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(2)|pancreas(1)|prostate(1)|skin(2)	15						TAATTGTCAAAGCAGCCCCTG	0.408000													79	78					0	0	1	0	0
XRRA1	143570	broad.mit.edu	37	11	74555242	74555242	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:74555242G>C	ENST00000340360.6	-	17	2321	c.1990C>G	c.(1990-1992)Cag>Gag	p.Q664E	XRRA1_ENST00000321448.8_Missense_Mutation_p.Q389E|XRRA1_ENST00000527087.1_Missense_Mutation_p.Q577E	NM_182969.2	NP_892014.1	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	664					response to X-ray	cytoplasm|nucleus				breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(3)	20						TAGGGTTTCTGAAGAGTGTCC	0.507000													22	180					0	0	1	0	0
ARHGEF6	9459	broad.mit.edu	37	X	135863013	135863013	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:135863013C>G	ENST00000250617.6	-	1	1234	c.29G>C	c.(28-30)tGg>tCg	p.W10S		NM_004840.2	NP_004831.1	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	10	CH.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(1)|lung(14)|prostate(1)	38	Acute lymphoblastic leukemia(192;0.000127)					AGATATAAGCCATGTCACGAT	0.463000													22	75					0	0	1	0	0
SLC28A2	9153	broad.mit.edu	37	15	45564553	45564553	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr15:45564553C>A	ENST00000347644.3	+	16	1774	c.1709C>A	c.(1708-1710)aCa>aAa	p.T570K	SLC28A2_ENST00000560767.1_3'UTR|CTD-2651B20.3_ENST00000560344.1_RNA|CTD-2651B20.3_ENST00000561404.1_RNA	NM_004212.3	NP_004203.2	O43868	S28A2_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 2	570					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding|nucleoside:sodium symporter activity|purine nucleoside transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(4)|skin(1)	26		all_cancers(109;8.53e-07)|all_epithelial(112;1.39e-05)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.77e-16)|GBM - Glioblastoma multiforme(94;2.71e-06)		GCCCTCTTCACAGGGGCCTGT	0.483000													5	44					0.217242	0.21964	1	1	0
ATP10B	23120	broad.mit.edu	37	5	160034073	160034073	+	Silent	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr5:160034073G>C	ENST00000327245.5	-	19	3705	c.2859C>G	c.(2857-2859)ctC>ctG	p.L953L		NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	953					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ATGCACAATTGAGGATGGATT	0.388000													4	53					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2160778	2160778	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr16:2160778C>T	ENST00000262304.4	-	15	4598	c.4390G>A	c.(4390-4392)Gag>Aag	p.E1464K	PKD1_ENST00000423118.1_Missense_Mutation_p.E1464K	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	1464	PKD 9.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						AGCACGGGCTCCTGCACCTCC	0.622000													7	80					0	0	1	0	0
ABCA5	23461	broad.mit.edu	37	17	67309290	67309290	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:67309290C>T	ENST00000392676.3	-	3	314	c.250G>A	c.(250-252)Gtg>Atg	p.V84M	ABCA5_ENST00000588877.1_Missense_Mutation_p.V84M|ABCA5_ENST00000392677.2_Missense_Mutation_p.V84M			Q8WWZ7	ABCA5_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 5	84					cholesterol efflux|high-density lipoprotein particle remodeling|negative regulation of macrophage derived foam cell differentiation	Golgi membrane|integral to membrane|late endosome membrane|lysosomal membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(18)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	54	Breast(10;3.72e-11)					ATATTAGTCACTGGAGTATAT	0.323000													12	40					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16676259	16676259	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr5:16676259T>C	ENST00000513610.1	-	34	5001	c.4547A>G	c.(4546-4548)aAc>aGc	p.N1516S	MYO10_ENST00000274203.9_Missense_Mutation_p.N873S|MYO10_ENST00000505695.1_Missense_Mutation_p.N855S|MYO10_ENST00000515803.1_Missense_Mutation_p.N855S|MYO10_ENST00000427430.2_Missense_Mutation_p.N873S	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	1516					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						GTTCAGGCAGTTCTCCTAAAA	0.438000													13	50					0	0	1	0	0
CANT1	124583	broad.mit.edu	37	17	76989735	76989735	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:76989735C>T	ENST00000302345.2	-	4	1597	c.1103G>A	c.(1102-1104)gGc>gAc	p.G368D	CANT1_ENST00000392446.5_Missense_Mutation_p.G368D|CANT1_ENST00000591773.1_Missense_Mutation_p.G368D	NM_001159773.1|NM_138793.3	NP_001153245.1|NP_620148.1	Q8WVQ1	CANT1_HUMAN	calcium activated nucleotidase 1	368					positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to membrane	calcium ion binding|nucleoside-diphosphatase activity|signal transducer activity		CANT1/ETV4(3)	cervix(1)|endometrium(1)|large_intestine(2)|lung(10)|prostate(1)|skin(1)	16			BRCA - Breast invasive adenocarcinoma(99;0.0362)|OV - Ovarian serous cystadenocarcinoma(97;0.139)			GGCGACTCTGCCGCTGTCCTC	0.587000			T	ETV4	prostate						OREG0024788	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	58					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237802435	237802435	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:237802435C>A	ENST00000366574.2	+	46	7366	c.7049C>A	c.(7048-7050)gCc>gAc	p.A2350D	RYR2_ENST00000360064.6_Missense_Mutation_p.A2348D|RYR2_ENST00000542537.1_Missense_Mutation_p.A2334D	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	2350	4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			ATGGAAGAAGCCATCAAAATC	0.502000													24	16					2.89027e-11	3.47439e-11	1	1	0
LRRC37A6P	387646	broad.mit.edu	37	10	27535638	27535638	+	RNA	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr10:27535638G>T	ENST00000574842.1	+	0	255																											TTCAAGGTCCGGATAACATGA	0.507000													39	150					1.03484e-13	1.27066e-13	1	1	0
PTPRT	11122	broad.mit.edu	37	20	41306758	41306758	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr20:41306758C>A	ENST00000373198.3	-	7	1136	c.901G>T	c.(901-903)Ggg>Tgg	p.G301W	PTPRT_ENST00000373193.3_Missense_Mutation_p.G301W|PTPRT_ENST00000373201.1_Missense_Mutation_p.G301W|PTPRT_ENST00000373184.1_Missense_Mutation_p.G301W|PTPRT_ENST00000356100.2_Missense_Mutation_p.G301W|PTPRT_ENST00000373187.1_Missense_Mutation_p.G301W|PTPRT_ENST00000373190.1_Missense_Mutation_p.G301W	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	301	Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TATGTGGCCCCCACAGCCAGC	0.532000													8	36					1.06961e-07	1.20364e-07	1	1	0
MUC6	4588	broad.mit.edu	37	11	1027505	1027505	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:1027505G>T	ENST00000421673.2	-	17	2044	c.1994C>A	c.(1993-1995)aCg>aAg	p.T665K		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	665					maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGTGTTACCCGTGCAGGGGAT	0.697000													17	41					0.00074312	0.000777053	1	1	0
RNF112	7732	broad.mit.edu	37	17	19317898	19317898	+	Splice_Site	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:19317898G>A	ENST00000461366.1	+	9	1148		c.e9-1			NM_007148.4	NP_009079.2	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112								GTP binding|GTPase activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	12						TTCTCTTTCAGCATCTGGACC	0.577000													18	29					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10491148	10491148	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:10491148G>T	ENST00000397077.1	-	4	655	c.80C>A	c.(79-81)aCa>aAa	p.T27K	ATP2B2_ENST00000360273.2_Missense_Mutation_p.T27K|ATP2B2_ENST00000343816.4_Missense_Mutation_p.T27K|ATP2B2_ENST00000383800.4_Missense_Mutation_p.T27K|ATP2B2_ENST00000352432.4_Missense_Mutation_p.T27K			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	27					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						CTCCTCCATTGTGCACCCGAA	0.577000													14	50					2.31682e-05	2.48502e-05	1	1	0
UQCRB	7381	broad.mit.edu	37	8	97244136	97244136	+	Nonsense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr8:97244136C>A	ENST00000287022.5	-	3	227	c.124G>T	c.(124-126)Gaa>Taa	p.E42*	UQCRB_ENST00000517523.1_Nonsense_Mutation_p.E10*|UQCRB_ENST00000523920.1_Nonsense_Mutation_p.E42*|UQCRB_ENST00000518406.1_Nonsense_Mutation_p.E42*	NM_001199975.2|NM_006294.4	NP_001186904.1|NP_006285.1	P14927	QCR7_HUMAN	ubiquinol-cytochrome c reductase binding protein	42					aerobic respiration|mitochondrial electron transport, ubiquinol to cytochrome c	mitochondrial respiratory chain	ubiquinol-cytochrome-c reductase activity			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	10	Breast(36;5.16e-05)					TTTACATCTTCATCCTCGTAT	0.363000													11	83					9.70103e-10	1.13344e-09	1	1	0
GC	2638	broad.mit.edu	37	4	72622571	72622571	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:72622571C>G	ENST00000273951.8	-	8	1235	c.892G>C	c.(892-894)Gac>Cac	p.D298H	GC_ENST00000513476.1_Missense_Mutation_p.D298H|GC_ENST00000503472.1_5'UTR|GC_ENST00000504199.1_Missense_Mutation_p.D317H	NM_000583.3|NM_001204306.1	NP_000574.2|NP_001191235.1	P02774	VTDB_HUMAN	group-specific component (vitamin D binding protein)	298	Albumin 2.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			endometrium(5)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	45		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	TGACAACAGTCTTCAAACTTA	0.418000													6	54					0	0	1	0	0
EYS	346007	broad.mit.edu	37	6	66112477	66112477	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:66112477G>T	ENST00000503581.1	-	7	1615	c.1078C>A	c.(1078-1080)Cca>Aca	p.P360T	EYS_ENST00000393380.2_Missense_Mutation_p.P360T|EYS_ENST00000370616.2_Missense_Mutation_p.P360T|EYS_ENST00000370618.3_Missense_Mutation_p.P360T|EYS_ENST00000370621.3_Missense_Mutation_p.P360T|EYS_ENST00000342421.5_Missense_Mutation_p.P360T	NM_001142800.1	NP_001136272.1	Q5T1H1	EYS_HUMAN	eyes shut homolog (Drosophila)	360	EGF-like 4.				response to stimulus|visual perception	extracellular region	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	69						GTAAATATTGGTGAACAGATG	0.313000													13	39					1.5842e-08	1.80939e-08	1	1	0
BAG6	7917	broad.mit.edu	37	6	31612330	31612330	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:31612330C>T	ENST00000404765.2	-	11	1708	c.1419G>A	c.(1417-1419)ctG>ctA	p.L473L	BAG6_ENST00000211379.5_Silent_p.L473L|BAG6_ENST00000362049.6_Silent_p.L473L|BAG6_ENST00000375964.6_Silent_p.L479L|BAG6_ENST00000375976.4_Silent_p.L473L|BAG6_ENST00000439687.2_Silent_p.L473L			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	479	4 X 29 AA approximate repeats.|Pro-rich.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						CAGGGGGTCCCAGGGGGCCAG	0.627000													4	34					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62570863	62570863	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:62570863G>C	ENST00000383710.4	-	8	1923	c.1574C>G	c.(1573-1575)tCt>tGt	p.S525C	CADPS_ENST00000357948.3_Missense_Mutation_p.S525C|CADPS_ENST00000283269.9_Missense_Mutation_p.S525C	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	525	PH.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CACTTACCCAGAATGCTTCAT	0.398000													8	73					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	7811314	7811314	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:7811314G>A	ENST00000303635.7	+	20	4952	c.4745G>A	c.(4744-4746)cGa>cAa	p.R1582Q	CAMTA1_ENST00000476864.1_Missense_Mutation_p.R146Q|CAMTA1_ENST00000439411.2_Missense_Mutation_p.R1568Q	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	1582	IQ 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		AGCAAATTCCGAAGTTACTAT	0.453000			T	WWTR1	epitheliod hemangioendothelioma								22	344					0	0	1	0	0
TSSC2	650368	broad.mit.edu	37	11	3427845	3427845	+	RNA	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:3427845C>T	ENST00000529482.1	+	0	962																											CTTCAAGTGGCAGGAGCAGAA	0.587000													6	48					0	0	1	0	0
MTHFD1	4522	broad.mit.edu	37	14	64882151	64882151	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr14:64882151G>C	ENST00000555709.1	+	5	703	c.316G>C	c.(316-318)Gag>Cag	p.E106Q	MTHFD1_ENST00000216605.7_Missense_Mutation_p.E162Q|MTHFD1_ENST00000545908.1_Missense_Mutation_p.E162Q|MTHFD1_ENST00000555252.1_Missense_Mutation_p.E86Q	NM_005956.3	NP_005947.3	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	106	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	30				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TTTAGATTCAGAGAATTCCAT	0.383000													13	121					0	0	1	0	0
PLCB2	5330	broad.mit.edu	37	15	40588986	40588986	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr15:40588986C>A	ENST00000260402.3	-	14	1696	c.1447G>T	c.(1447-1449)Ggc>Tgc	p.G483C	PLCB2_ENST00000557821.1_Missense_Mutation_p.G483C|PLCB2_ENST00000456256.2_Missense_Mutation_p.G483C	NM_004573.2	NP_004564.2	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	483					activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(4)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(3)	39		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		GGGCTGCTGCCCTCAGCCTCC	0.602000													20	45					2.4624e-09	2.85513e-09	1	1	0
IGHV4-59	28392	broad.mit.edu	37	14	107083713	107083713	+	RNA	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr14:107083713C>A	ENST00000455737.1	-	0	12																											CCAGGACTCTCAGAAAGTATT	0.488000													6	41					0.000157383	0.000165325	1	1	0
VANGL1	81839	broad.mit.edu	37	1	116206605	116206605	+	Missense_Mutation	SNP	A	A	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:116206605A>T	ENST00000355485.2	+	4	799	c.528A>T	c.(526-528)agA>agT	p.R176S	VANGL1_ENST00000369510.3_Missense_Mutation_p.R174S|VANGL1_ENST00000310260.3_Missense_Mutation_p.R176S|VANGL1_ENST00000369509.1_Missense_Mutation_p.R176S	NM_001172411.1|NM_138959.2	NP_001165882.1|NP_620409.1	Q8TAA9	VANG1_HUMAN	VANGL planar cell polarity protein 1	176					multicellular organismal development	integral to membrane	protein binding	p.F171fs*93(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|liver(2)|lung(13)|urinary_tract(1)	27	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		GCAAGCGGAGAGCTGACATGC	0.488000													55	126					0	0	1	0	0
ADCK1	57143	broad.mit.edu	37	14	78390887	78390887	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr14:78390887G>C	ENST00000238561.5	+	8	1045	c.946G>C	c.(946-948)Gtg>Ctg	p.V316L	ADCK1_ENST00000341211.5_Missense_Mutation_p.V248L|ADCK1_ENST00000556560.1_3'UTR	NM_020421.3	NP_065154.2	Q86TW2	ADCK1_HUMAN	aarF domain containing kinase 1	323	Protein kinase.					extracellular region	ATP binding|protein serine/threonine kinase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|skin(2)|stomach(2)	25			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0376)		CAATGTACTGGTGCGGAAGCA	0.567000													20	50					0	0	1	0	0
APOLD1	81575	broad.mit.edu	37	12	12940525	12940525	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:12940525A>G	ENST00000356591.4	+	2	771	c.686A>G	c.(685-687)aAg>aGg	p.K229R	APOLD1_ENST00000326765.6_Missense_Mutation_p.K260R|RP11-59H1.3_ENST00000534843.1_Intron	NM_030817.2	NP_110444.3	Q96LR9	APLD1_HUMAN	apolipoprotein L domain containing 1	260					angiogenesis|cell differentiation|lipid transport|lipoprotein metabolic process	extracellular region|integral to membrane|plasma membrane	lipid binding			breast(1)|endometrium(1)|large_intestine(1)|lung(1)|ovary(1)	5		Prostate(47;0.0632)		BRCA - Breast invasive adenocarcinoma(232;0.0338)|GBM - Glioblastoma multiforme(207;0.149)		CTCTGCACCAAGTCCAGTCGT	0.577000													12	64					0	0	1	0	0
SEMG2	6407	broad.mit.edu	37	20	43851204	43851204	+	Missense_Mutation	SNP	A	A	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr20:43851204A>C	ENST00000372769.3	+	2	1021	c.931A>C	c.(931-933)Aaa>Caa	p.K311Q		NM_003008.2	NP_002999.1	Q02383	SEMG2_HUMAN	semenogelin II	311	4 X 60 AA tandem repeats, type I.|Repeat-rich region.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Myeloproliferative disorder(115;0.0122)				AGATGTATCCAAAGGCAGCAT	0.403000													28	63					0	0	1	0	0
ELAC1	55520	broad.mit.edu	37	18	48510693	48510693	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr18:48510693C>G	ENST00000269466.3	+	3	492	c.385C>G	c.(385-387)Caa>Gaa	p.Q129E	RP11-729L2.2_ENST00000588256.1_Intron|SMAD4_ENST00000452201.2_Intron|ELAC1_ENST00000588577.1_Intron|RP11-729L2.2_ENST00000590722.2_Intron|ELAC1_ENST00000591429.1_Missense_Mutation_p.Q129E	NM_018696.2	NP_061166.1	Q9H777	RNZ1_HUMAN	elaC ribonuclease Z 1	129					tRNA 3'-trailer cleavage	nucleus	endoribonuclease activity, producing 5'-phosphomonoesters|metal ion binding			kidney(1)|large_intestine(4)|prostate(1)	6		Colorectal(6;0.0269)|all_epithelial(6;0.0729)		Colorectal(21;0.000943)|COAD - Colon adenocarcinoma(17;0.0398)|READ - Rectum adenocarcinoma(32;0.0894)|STAD - Stomach adenocarcinoma(97;0.18)		TACAGCAGATCAATGTCCTGC	0.468000													9	57					0	0	1	0	0
EXOSC10	5394	broad.mit.edu	37	1	11159855	11159855	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:11159855G>A	ENST00000544779.1	-	1	39	c.34C>T	c.(34-36)Ctg>Ttg	p.L12L	RP4-635E18.6_ENST00000435388.1_RNA|EXOSC10_ENST00000304457.7_Silent_p.L12L|EXOSC10_ENST00000376936.4_Silent_p.L12L|RP4-635E18.6_ENST00000447600.1_RNA			Q01780	EXOSX_HUMAN	exosome component 10	12					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|stomach(3)|upper_aerodigestive_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		GTCGCCGACAGGACCCTGGGC	0.672000													10	78					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126135286	126135286	+	Silent	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:126135286C>A	ENST00000299308.3	+	7	1694	c.1686C>A	c.(1684-1686)tcC>tcA	p.S562S	TMEM132B_ENST00000535886.1_Silent_p.S74S	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	562						integral to membrane		p.S562S(1)		NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GAGGCTGCTCCCTGCAGTACC	0.572000													7	62					0.00198382	0.00206968	1	1	0
LAMA4	3910	broad.mit.edu	37	6	112462591	112462591	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:112462591G>T	ENST00000230538.7	-	21	3179	c.2782C>A	c.(2782-2784)Cct>Act	p.P928T	LAMA4_ENST00000389463.4_Missense_Mutation_p.P921T|LAMA4_ENST00000522006.1_Missense_Mutation_p.P921T|LAMA4_ENST00000424408.2_Missense_Mutation_p.P921T	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	928	Laminin G-like 1.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		AAGTAAGCAGGCCAGGAACTG	0.428000													24	68					9.57634e-11	1.13921e-10	1	1	0
CEP164	22897	broad.mit.edu	37	11	117234158	117234158	+	Nonsense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:117234158C>G	ENST00000278935.3	+	8	848	c.701C>G	c.(700-702)tCa>tGa	p.S234*		NM_014956.4	NP_055771.4	Q9UPV0	CE164_HUMAN	centrosomal protein 164kDa	234					cell division|DNA repair|G2/M transition of mitotic cell cycle|mitosis	centriole|cytosol|nucleus				breast(3)|central_nervous_system(1)|kidney(7)|large_intestine(12)|lung(18)|ovary(3)|prostate(3)	47	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;4e-05)|Epithelial(105;0.0008)		GTCCACAGCTCAAGTGAGCCT	0.512000													6	40					0	0	1	0	0
RBAK	57786	broad.mit.edu	37	7	5112640	5112640	+	Missense_Mutation	SNP	C	C	T	rs146417655		TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:5112640C>T	ENST00000407184.1	+	8	789	c.523C>T	c.(523-525)Cgc>Tgc	p.R175C	RBAK_ENST00000498308.1_3'UTR|RBAK_ENST00000396904.2_3'UTR			Q9NYW8	RBAK_HUMAN	RB-associated KRAB zinc finger	0	Required for interaction with RB1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(2)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)	10		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0916)|OV - Ovarian serous cystadenocarcinoma(56;2.44e-14)		GTGGTGGCCACGCGACCAGAA	0.687000													10	46					0	0	1	0	0
RAP1GDS1	5910	broad.mit.edu	37	4	99214554	99214554	+	Splice_Site	SNP	A	A	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:99214554A>T	ENST00000453712.2	+	2	101		c.e2-1		RAP1GDS1_ENST00000380158.4_Splice_Site|RAP1GDS1_ENST00000512857.1_Splice_Site|RAP1GDS1_ENST00000339360.5_Splice_Site|RAP1GDS1_ENST00000408900.3_Intron|RAP1GDS1_ENST00000408927.3_Intron|RAP1GDS1_ENST00000264572.7_Splice_Site			P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1								binding|GTPase activator activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)	28				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		TTTTTCTTTAAGCAGATAATC	0.368000			T	NUP98	T-ALL								8	29					0	0	1	0	0
C2CD3	26005	broad.mit.edu	37	11	73748566	73748566	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:73748566C>G	ENST00000334126.7	-	30	6064	c.5838G>C	c.(5836-5838)gaG>gaC	p.E1946D	C2CD3_ENST00000313663.7_Missense_Mutation_p.E1946D			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1946						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					TACTGGATTTCTCCAGGATAC	0.502000													21	169					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108469084	108469084	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr10:108469084G>A	ENST00000263054.6	-	7	1047	c.1040C>T	c.(1039-1041)aCt>aTt	p.T347I	SORCS1_ENST00000344440.6_Missense_Mutation_p.T347I	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	347						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CATTCGGCAAGTTAGATAATG	0.398000													9	45					0	0	1	0	0
GPR133	283383	broad.mit.edu	37	12	131561352	131561352	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:131561352A>G	ENST00000261654.5	+	14	2039	c.1480A>G	c.(1480-1482)Aag>Gag	p.K494E	GPR133_ENST00000376682.4_Missense_Mutation_p.K180E|GPR133_ENST00000535015.1_Missense_Mutation_p.K526E|GPR133_ENST00000543617.1_Missense_Mutation_p.K13E	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	494					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TCAGACACGTAAGCAGCACAG	0.562000													7	81					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56140420	56140420	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr20:56140420C>A	ENST00000319441.4	+	10	1593	c.1429C>A	c.(1429-1431)Cat>Aat	p.H477N	PCK1_ENST00000535860.1_3'UTR|PCK1_ENST00000543666.1_Missense_Mutation_p.H160N	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	477					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			AATCATCATGCATGACCCCTT	0.502000													17	64					5.3912e-06	5.90711e-06	1	1	0
STAB1	23166	broad.mit.edu	37	3	52554261	52554261	+	Silent	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:52554261C>A	ENST00000321725.6	+	52	5530	c.5454C>A	c.(5452-5454)acC>acA	p.T1818T		NM_015136.2	NP_055951.2	Q9NY15	STAB1_HUMAN	stabilin 1	1818	FAS1 6.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			breast(4)|central_nervous_system(3)|endometrium(7)|kidney(2)|large_intestine(13)|liver(1)|lung(27)|ovary(1)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	76				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		CACTTCGAACCATGCATGGGA	0.627000													7	134					3.09899e-07	3.45337e-07	1	1	0
RIMBP2	23504	broad.mit.edu	37	12	130892271	130892271	+	Splice_Site	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:130892271C>A	ENST00000261655.4	-	16	3088	c.2925_splice	c.e16+1	p.E975_splice		NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	975	SH3 3.					cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TGGCTGGTACCTCGACATCGA	0.572000													92	248					6.79372e-55	8.86474e-55	1	1	0
MYT1	4661	broad.mit.edu	37	20	62854695	62854695	+	Silent	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr20:62854695C>A	ENST00000536311.1	+	16	2956	c.2592C>A	c.(2590-2592)gcC>gcA	p.A864A	MYT1_ENST00000360149.4_Intron|MYT1_ENST00000328439.1_Silent_p.A837A			Q01538	MYT1_HUMAN	myelin transcription factor 1	837					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					TCATGGCTGCCCACTCTGCTG	0.552000													95	272					2.77303e-49	3.60809e-49	1	1	0
KCNJ12	3768	broad.mit.edu	37	17	21318743	21318743	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:21318743G>T	ENST00000583088.1	+	3	984	c.89G>T	c.(88-90)gGc>gTc	p.G30V	KCNJ12_ENST00000331718.5_Missense_Mutation_p.G30V	NM_021012.4	NP_066292.2			potassium inwardly-rectifying channel, subfamily J, member 12											NS(1)|breast(4)|endometrium(4)|kidney(1)|large_intestine(5)|lung(39)|ovary(5)|skin(8)|stomach(3)	70				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)		GGCGCCAACGGCTTCGGCAAC	0.647000										Prostate(3;0.18)			6	44					0.248553	0.250191	1	1	0
SNRNP200	23020	broad.mit.edu	37	2	96949018	96949018	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:96949018C>T	ENST00000323853.5	-	34	4913	c.4836G>A	c.(4834-4836)acG>acA	p.T1612T	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	1612	Helicase C-terminal 2.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						CATTTAGCAGCGTTTCCTTGA	0.592000													33	57					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118374583	118374583	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:118374583G>C	ENST00000534358.1	+	27	7999	c.7976G>C	c.(7975-7977)cGa>cCa	p.R2659P	KMT2A_ENST00000389506.5_Missense_Mutation_p.R2656P|KMT2A_ENST00000354520.4_Missense_Mutation_p.R2618P	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		GGGAAGAAGCGAGGCAAGAGA	0.448000													14	30					0	0	1	0	0
SMG8	55181	broad.mit.edu	37	17	57287917	57287917	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:57287917C>G	ENST00000543872.2	+	2	769	c.505C>G	c.(505-507)Ctt>Gtt	p.L169V	SMG8_ENST00000580498.1_Intron|CTD-2510F5.6_ENST00000577660.1_Intron|SMG8_ENST00000300917.5_Missense_Mutation_p.L169V|SMG8_ENST00000578922.1_Missense_Mutation_p.L169V			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	169					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						TTGTCGGGCTCTTCAGAGCGG	0.522000													6	66					0	0	1	0	0
OR2C3	81472	broad.mit.edu	37	1	247695802	247695802	+	Silent	SNP	T	T	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:247695802T>A	ENST00000366487.3	-	2	373	c.12A>T	c.(10-12)atA>atT	p.I4I	GCSAML_ENST00000527541.1_Intron|GCSAML_ENST00000366489.1_Intron|GCSAML_ENST00000366490.3_Intron|GCSAML_ENST00000531662.1_Intron|GCSAML_ENST00000527084.1_Intron|GCSAML_ENST00000366491.2_Intron|GCSAML_ENST00000463359.1_Intron	NM_198074.4	NP_932340.3	Q8N628	OR2C3_HUMAN	olfactory receptor, family 2, subfamily C, member 3	4					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|large_intestine(2)|lung(31)|ovary(1)|prostate(1)|skin(2)	43	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0242)	OV - Ovarian serous cystadenocarcinoma(106;0.0241)			TCACATTGGCTATTTCCATCA	0.483000													3	38					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154158072	154158072	+	Missense_Mutation	SNP	C	C	G	rs35702375		TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:154158072C>G	ENST00000360256.4	-	14	4193	c.3993G>C	c.(3991-3993)aaG>aaC	p.K1331N		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1331	B.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TCAAAGCTCTCTTACTACGTT	0.398000													16	161					0	0	1	0	0
EPHA2	1969	broad.mit.edu	37	1	16462184	16462184	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:16462184C>G	ENST00000358432.5	-	6	1548	c.1394G>C	c.(1393-1395)cGa>cCa	p.R465P		NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	465	Fibronectin type-III 2.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CTTCCACACTCGGCTCTGCTG	0.662000													29	78					0	0	1	0	0
DHX40	79665	broad.mit.edu	37	17	57647885	57647885	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:57647885C>T	ENST00000251241.4	+	3	434	c.287C>T	c.(286-288)tCa>tTa	p.S96L	DHX40_ENST00000451169.2_5'UTR|DHX40_ENST00000425628.3_Intron	NM_024612.4	NP_078888.4	Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	96	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(7)|large_intestine(6)|lung(6)|prostate(1)	20	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					ATAGGGTTTTCACAACATGGT	0.368000													8	126					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	147743929	147743929	+	Missense_Mutation	SNP	A	A	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:147743929A>C	ENST00000370460.2	+	3	1160	c.681A>C	c.(679-681)gaA>gaC	p.E227D	AFF2_ENST00000370458.1_Missense_Mutation_p.E223D|AFF2_ENST00000342251.3_Missense_Mutation_p.E223D|AFF2_ENST00000370457.5_Missense_Mutation_p.E223D	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	227					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					CTAGTGGAGAAGATGCTTTCA	0.458000													34	248					0	0	1	0	0
FLII	2314	broad.mit.edu	37	17	18158126	18158126	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:18158126C>T	ENST00000327031.4	-	5	595	c.370G>A	c.(370-372)Gag>Aag	p.E124K	FLII_ENST00000545457.2_Missense_Mutation_p.E124K|FLII_ENST00000579294.1_Missense_Mutation_p.E113K|FLII_ENST00000379450.4_Missense_Mutation_p.E93K|FLII_ENST00000578558.1_Missense_Mutation_p.E124K|FLII_ENST00000584444.1_5'UTR	NM_002018.3	NP_002009.1	Q13045	FLII_HUMAN	flightless I homolog (Drosophila)	124	Interaction with LRRFIP1 and LRRFIP2.				multicellular organismal development|muscle contraction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|nucleus	actin binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32	all_neural(463;0.228)					TTGGCGTTCTCCAGCTCCCGC	0.662000													8	65					0	0	1	0	0
TMIGD2	126259	broad.mit.edu	37	19	4292883	4292883	+	Splice_Site	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:4292883C>T	ENST00000301272.2	-	5	608		c.e5-1		TMIGD2_ENST00000595645.1_Splice_Site|TMIGD2_ENST00000600349.1_Splice_Site|TMIGD2_ENST00000600114.1_Splice_Site	NM_001169126.1|NM_144615.2	NP_001162597.1|NP_653216.2	Q96BF3	TMIG2_HUMAN	transmembrane and immunoglobulin domain containing 2							integral to membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|skin(2)	19				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		AATGCATTTCCTAGGATGGAT	0.537000													34	33					0	0	1	0	0
TTC21B	79809	broad.mit.edu	37	2	166758261	166758261	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:166758261C>A	ENST00000243344.7	-	20	2865	c.2728G>T	c.(2728-2730)Gct>Tct	p.A910S		NM_024753.4	NP_079029.3	Q7Z4L5	TT21B_HUMAN	tetratricopeptide repeat domain 21B	910						cilium axoneme|cytoplasm|cytoskeleton	binding			breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(9)|lung(28)|ovary(2)|pancreas(2)|skin(2)|urinary_tract(1)	58						TGAACCAGAGCCTCTCTATAA	0.338000													20	66					8.34094e-07	9.20518e-07	1	1	0
F8	2157	broad.mit.edu	37	X	154159815	154159815	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:154159815C>T	ENST00000360256.4	-	14	2450	c.2250G>A	c.(2248-2250)ctG>ctA	p.L750L		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	750					acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TGTTTTTACTCAGCAAGTATG	0.413000													11	142					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140995101	140995101	+	Silent	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:140995101A>G	ENST00000285879.4	+	4	2197	c.1911A>G	c.(1909-1911)ccA>ccG	p.P637P	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	637							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCCACTCCATCCAGTCTTC	0.567000										HNSCC(15;0.026)			67	345					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22205117	22205117	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:22205117G>A	ENST00000374695.3	-	19	2590	c.2511C>T	c.(2509-2511)gcC>gcT	p.A837A		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	837	Laminin EGF-like 3.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	CGTCACATGTGGCTTGGCCAT	0.642000													10	56					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13830724	13830724	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr5:13830724G>C	ENST00000265104.4	-	36	6147	c.6043C>G	c.(6043-6045)Ctt>Gtt	p.L2015V		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2015	AAA 1 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					ATCCGTCCAAGTCCTCGGAAA	0.413000									Kartagener syndrome				5	113					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40399695	40399695	+	Silent	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:40399695G>T	ENST00000338305.6	-	2	1700	c.1158C>A	c.(1156-1158)acC>acA	p.T386T		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	386						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					CAGTGCGGCTGGTGCTGTTGC	0.647000													25	46					3.93418e-24	5.06139e-24	1	1	0
DMD	1756	broad.mit.edu	37	X	31893485	31893485	+	Silent	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:31893485G>T	ENST00000357033.4	-	48	7124	c.6918C>A	c.(6916-6918)tcC>tcA	p.S2306S	DMD_ENST00000378707.3_5'UTR|DMD_ENST00000474231.1_5'UTR|DMD_ENST00000378677.2_Silent_p.S2302S|DMD_ENST00000343523.2_5'UTR|DMD_ENST00000541735.1_5'UTR|DMD_ENST00000359836.1_5'UTR	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2306			Missing (in DMD).		muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				GTAAAGCTCTGGAAACCTGAA	0.303000													10	24					2.80697e-09	3.22204e-09	1	1	0
PTPRD	5789	broad.mit.edu	37	9	8484238	8484238	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr9:8484238C>A	ENST00000381196.4	-	27	3837	c.3294G>T	c.(3292-3294)agG>agT	p.R1098S	PTPRD_ENST00000397606.3_Missense_Mutation_p.R677S|PTPRD_ENST00000537002.1_Missense_Mutation_p.R684S|PTPRD_ENST00000355233.5_Missense_Mutation_p.R687S|PTPRD_ENST00000358503.5_Missense_Mutation_p.R1076S|PTPRD_ENST00000360074.4_Missense_Mutation_p.R1085S|PTPRD_ENST00000397611.3_Missense_Mutation_p.R684S|PTPRD_ENST00000486161.1_Missense_Mutation_p.R687S|PTPRD_ENST00000356435.5_Missense_Mutation_p.R1098S|PTPRD_ENST00000397617.3_Missense_Mutation_p.R677S|PTPRD_ENST00000540109.1_Missense_Mutation_p.R1098S	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1098	Fibronectin type-III 8.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TTGCCGTGACCCTGTGCTGCA	0.488000										TSP Lung(15;0.13)			35	54					1.45844e-13	1.786e-13	1	1	0
F8	2157	broad.mit.edu	37	X	154176162	154176162	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:154176162C>A	ENST00000360256.4	-	13	2124	c.1924G>T	c.(1924-1926)Gat>Tat	p.D642Y		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	642	F5/8 type A 2.|Plastocyanin-like 4.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TGCAAACTATCAAAAACATAG	0.378000													5	41					0.014758	0.0152233	1	1	0
PLIN5	440503	broad.mit.edu	37	19	4523862	4523862	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:4523862C>G	ENST00000381848.3	-	8	1150	c.1070G>C	c.(1069-1071)tGc>tCc	p.C357S		NM_001013706.2	NP_001013728.2	Q00G26	PLIN5_HUMAN	perilipin 5	357						lipid particle				endometrium(4)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	10						CTCGTCCACGCAGGCGTGCGC	0.746000													4	22					0	0	1	0	0
DDX39B	7919	broad.mit.edu	37	6	31498604	31498604	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:31498604C>G	ENST00000417556.2	-	11	1897	c.1267G>C	c.(1267-1269)Gag>Cag	p.E423Q	DDX39B_ENST00000415382.2_Missense_Mutation_p.E330Q|DDX39B_ENST00000396172.1_Missense_Mutation_p.E408Q|DDX39B_ENST00000376177.2_Missense_Mutation_p.L415F|ATP6V1G2-DDX39B_ENST00000376185.1_3'UTR|DDX39B_ENST00000462421.1_5'UTR|DDX39B_ENST00000458640.1_Missense_Mutation_p.E408Q			Q13838	DX39B_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	408					intronless viral mRNA export from host nucleus|RNA secondary structure unwinding|spliceosome assembly	nuclear speck|spliceosomal complex|transcription export complex	ATP binding|ATP-dependent protein binding|ATP-dependent RNA helicase activity|identical protein binding|U4 snRNA binding|U6 snRNA binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	19						ATATTGACCTCAAAGCGATCC	0.493000													8	68					0	0	1	0	0
TAS2R43	259289	broad.mit.edu	37	12	11244547	11244547	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:11244547G>C	ENST00000531678.1	-	1	365	c.282C>G	c.(280-282)ttC>ttG	p.F94L	PRR4_ENST00000536668.1_Intron|TAS2R14_ENST00000381852.4_Intron	NM_176884.2	NP_795365.2	P59537	T2R43_HUMAN	taste receptor, type 2, member 43	94					detection of chemical stimulus involved in sensory perception of bitter taste	cilium membrane|motile cilium	bitter taste receptor activity			endometrium(1)|ovary(1)|prostate(2)|urinary_tract(1)	5			OV - Ovarian serous cystadenocarcinoma(49;0.0344)	BRCA - Breast invasive adenocarcinoma(232;0.196)		GCCAGTTGCTGAAATGGTTGA	0.343000													27	24					0	0	1	0	0
IFNA8	3445	broad.mit.edu	37	9	21409697	21409697	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr9:21409697C>T	ENST00000380205.1	+	1	552	c.522C>T	c.(520-522)tcC>tcT	p.S174S		NM_002170.3	NP_002161.2	P32881	IFNA8_HUMAN	interferon, alpha 8	174					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	9				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0174)		TCATGAGATCCTTCTCTTTAT	0.398000													73	125					0	0	1	0	0
CCDC88A	55704	broad.mit.edu	37	2	55546042	55546042	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:55546042C>G	ENST00000436346.1	-	19	4102	c.3261G>C	c.(3259-3261)caG>caC	p.Q1087H	CCDC88A_ENST00000336838.6_Missense_Mutation_p.Q1086H|CCDC88A_ENST00000263630.8_Missense_Mutation_p.Q1087H|AC012358.8_ENST00000599352.1_RNA|AC012358.8_ENST00000599475.1_RNA|AC012358.8_ENST00000594078.1_RNA|AC012358.8_ENST00000600219.1_RNA|CCDC88A_ENST00000413716.2_Missense_Mutation_p.Q1086H	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	1087					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						CTGTCTGCCTCTGAAGTGCAA	0.398000													28	79					0	0	1	0	0
ZNF236	7776	broad.mit.edu	37	18	74637300	74637300	+	Nonsense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr18:74637300C>T	ENST00000253159.8	+	22	4009	c.3811C>T	c.(3811-3813)Cag>Tag	p.Q1271*	ZNF236_ENST00000320610.9_Nonsense_Mutation_p.Q1273*	NM_007345.3	NP_031371.3	Q9UL36	ZN236_HUMAN	zinc finger protein 236	1271					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(43)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	94		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		GACACACATGCAGTTTCATTA	0.527000													5	74					0	0	1	0	0
EIF4A2	1974	broad.mit.edu	37	3	186501404	186501404	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:186501404C>T	ENST00000323963.5	+	1	69	c.5C>T	c.(4-6)tCt>tTt	p.S2F	EIF4A2_ENST00000356531.5_5'UTR|RP11-573D15.9_ENST00000577781.1_RNA|EIF4A2_ENST00000440191.2_Missense_Mutation_p.S2F			Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	2					interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|urinary_tract(1)	28	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		CGGATCATGTCTGGTGGCTCC	0.577000			T	BCL6	NHL								39	80					0	0	1	0	0
LRRC37B	114659	broad.mit.edu	37	17	30348805	30348805	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:30348805A>G	ENST00000327564.7	+	1	782	c.721A>G	c.(721-723)Aaa>Gaa	p.K241E	LRRC37B_ENST00000394713.3_Missense_Mutation_p.K214E|LRRC37B_ENST00000341671.7_Missense_Mutation_p.K214E|LRRC37B_ENST00000584368.1_Missense_Mutation_p.K226E|LRRC37B_ENST00000543378.2_Missense_Mutation_p.K132E			Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B	214						integral to membrane				endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	29		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				CCAATTATCCAAACCTCAGCG	0.468000													12	131					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882594	228882594	+	Silent	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:228882594C>G	ENST00000392056.3	-	7	3022	c.2976G>C	c.(2974-2976)gtG>gtC	p.V992V	SPHKAP_ENST00000344657.5_Silent_p.V992V	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	992						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		TGTGTTTCCTCACAGCGGTCC	0.532000													20	70					0	0	1	0	0
TLR8	51311	broad.mit.edu	37	X	12939590	12939590	+	Missense_Mutation	SNP	G	G	C	rs149915624		TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:12939590G>C	ENST00000218032.6	+	2	2518	c.2431G>C	c.(2431-2433)Ggg>Cgg	p.G811R	TLR8_ENST00000311912.5_Missense_Mutation_p.G829R	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	811	LRRCT.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						GGATCAAAGAGGGAAGAGTAT	0.413000													6	134					0	0	1	0	0
TMEM63B	55362	broad.mit.edu	37	6	44115224	44115224	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:44115224G>T	ENST00000259746.9	+	12	1157	c.974G>T	c.(973-975)cGa>cTa	p.R325L	TMEM63B_ENST00000323267.6_Missense_Mutation_p.R325L			Q5T3F8	TM63B_HUMAN	transmembrane protein 63B	325						integral to membrane	nucleotide binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|ovary(1)|pancreas(2)|prostate(2)|stomach(4)	35	all_cancers(18;1.66e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00309)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0215)			TGTGTGGTGCGAGGCTGTGAG	0.617000													14	38					1.5842e-08	1.80939e-08	1	1	0
TAS2R16	50833	broad.mit.edu	37	7	122634998	122634998	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:122634998C>T	ENST00000249284.2	-	1	756	c.691G>A	c.(691-693)Gtc>Atc	p.V231I		NM_016945.2	NP_058641.1	Q9NYV7	T2R16_HUMAN	taste receptor, type 2, member 16	231					detection of chemical stimulus involved in sensory perception of bitter taste	endoplasmic reticulum|external side of plasma membrane|trans-Golgi network	bitter taste receptor activity|protein binding	p.V231I(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						ATAAATAAGACGGCAAGGGAC	0.433000													43	45					0	0	1	0	0
ENDOD1	23052	broad.mit.edu	37	11	94862742	94862742	+	Silent	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:94862742A>G	ENST00000278505.4	+	2	1620	c.1502A>G	c.(1501-1503)tAa>tGa	p.*501*		NM_015036.2	NP_055851.1	O94919	ENDD1_HUMAN	endonuclease domain containing 1	0						extracellular region	endonuclease activity|metal ion binding|nucleic acid binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)	11		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.00824)				GGGGAGTTATAAACTCAAAAA	0.383000													17	59					0	0	1	0	0
NSL1	25936	broad.mit.edu	37	1	212964926	212964926	+	Silent	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:212964926G>C	ENST00000366977.3	-	1	198	c.180C>G	c.(178-180)ctC>ctG	p.L60L	NSL1_ENST00000422588.2_Silent_p.L60L|NSL1_ENST00000366975.6_Silent_p.L60L|NSL1_ENST00000473995.1_5'UTR|NSL1_ENST00000366976.1_Silent_p.L60L	NM_015471.3	NP_056286.3	Q96IY1	NSL1_HUMAN	NSL1, MIS12 kinetochore complex component	60					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	9				OV - Ovarian serous cystadenocarcinoma(81;0.00597)|all cancers(67;0.00893)|GBM - Glioblastoma multiforme(131;0.0514)|Epithelial(68;0.102)		GAGCGTCCCCGAGCTTTTGCA	0.607000													12	297					0	0	1	0	0
C11orf30	56946	broad.mit.edu	37	11	76169287	76169287	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:76169287G>A	ENST00000529032.1	+	4	306	c.306G>A	c.(304-306)ctG>ctA	p.L102L	C11orf30_ENST00000525959.1_3'UTR|C11orf30_ENST00000524767.1_Silent_p.L116L|C11orf30_ENST00000343878.3_Silent_p.L102L|C11orf30_ENST00000533248.1_Silent_p.L116L|C11orf30_ENST00000334736.3_Silent_p.L102L|C11orf30_ENST00000525038.1_Silent_p.L116L|C11orf30_ENST00000525919.1_Silent_p.L102L|C11orf30_ENST00000524490.1_Silent_p.L102L			Q7Z589	EMSY_HUMAN	chromosome 11 open reading frame 30	102	Interaction with BRCA2.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(10)|liver(1)|lung(23)|ovary(5)|prostate(2)|skin(4)|stomach(1)|urinary_tract(2)	60						TGGTACCACTGATGCCCCGGC	0.463000													12	64					0	0	1	0	0
CAPN7	23473	broad.mit.edu	37	3	15262455	15262455	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:15262455A>G	ENST00000253693.2	+	5	858	c.605A>G	c.(604-606)cAg>cGg	p.Q202R		NM_014296.2	NP_055111.1	Q9Y6W3	CAN7_HUMAN	calpain 7	202					proteolysis	nucleus	calcium-dependent cysteine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|skin(2)	22						GCACAAGGACAGAGATACACA	0.368000													5	59					0	0	1	0	0
PIPOX	51268	broad.mit.edu	37	17	27383322	27383322	+	Nonstop_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:27383322G>C	ENST00000323372.4	+	8	1498	c.1172G>C	c.(1171-1173)tGa>tCa	p.*391S	PIPOX_ENST00000583215.1_3'UTR	NM_016518.2	NP_057602.2	Q9P0Z9	SOX_HUMAN	pipecolic acid oxidase	0					tetrahydrofolate metabolic process	peroxisome	L-pipecolate oxidase activity|sarcosine oxidase activity			endometrium(2)|large_intestine(4)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	10	Lung NSC(42;0.015)		Epithelial(11;9.87e-06)|BRCA - Breast invasive adenocarcinoma(11;3.92e-05)|all cancers(11;5.59e-05)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)		Glycine(DB00145)	GCCCACCTTTGACCTCTGGCC	0.483000													5	46					0	0	1	0	0
C2CD5	9847	broad.mit.edu	37	12	22677460	22677460	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:22677460G>A	ENST00000333957.4	-	6	802	c.547C>T	c.(547-549)Cgc>Tgc	p.R183C	C2CD5_ENST00000542676.1_Missense_Mutation_p.R183C|C2CD5_ENST00000544930.1_5'UTR|C2CD5_ENST00000446597.1_Missense_Mutation_p.R183C|C2CD5_ENST00000536386.1_Missense_Mutation_p.R183C|C2CD5_ENST00000545552.1_Missense_Mutation_p.R183C|C2CD5_ENST00000396028.2_Missense_Mutation_p.R183C|C2CD5_ENST00000540703.1_5'UTR	NM_014802.1	NP_055617.1			C2 calcium-dependent domain containing 5																		CTTGGTGTGCGAATTCGATCA	0.363000													9	55					0	0	1	0	0
LDB2	9079	broad.mit.edu	37	4	16504392	16504392	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:16504392G>T	ENST00000304523.5	-	8	1319	c.996C>A	c.(994-996)aaC>aaA	p.N332K	LDB2_ENST00000515064.1_Missense_Mutation_p.N330K|LDB2_ENST00000441778.2_3'UTR|LDB2_ENST00000502640.1_3'UTR|RP11-446J8.1_ENST00000512370.1_RNA	NM_001290.3	NP_001281.1	O43679	LDB2_HUMAN	LIM domain binding 2	332	LIM-binding domain (LID) (By similarity).						LIM domain binding|transcription cofactor activity	p.N332K(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(23)|urinary_tract(1)	33						CGTCCATGCCGTTGGCCGCAT	0.522000													30	170					2.36697e-06	2.60595e-06	1	1	0
C5orf51	285636	broad.mit.edu	37	5	41917195	41917195	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr5:41917195G>C	ENST00000381647.2	+	6	698	c.679G>C	c.(679-681)Gat>Cat	p.D227H		NM_175921.4	NP_787117.3	A6NDU8	CE051_HUMAN	chromosome 5 open reading frame 51	227										endometrium(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	11						GTATTGTGCTGATCAGCAACC	0.428000													10	96					0	0	1	0	0
OR51E1	143503	broad.mit.edu	37	11	4674623	4674623	+	Nonsense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:4674623C>G	ENST00000530215.1	+	2	238	c.197C>G	c.(196-198)tCa>tGa	p.S66*	OR51E1_ENST00000396952.5_Silent_p.L289L			Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E, member 1	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(13)|ovary(1)|pancreas(1)|skin(1)|stomach(2)	30		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTCCTGTGCTCAACCCAATTG	0.517000													12	84					0	0	1	0	0
C3orf27	23434	broad.mit.edu	37	3	128292493	128292493	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:128292493G>T	ENST00000356020.2	-	3	1046	c.80C>A	c.(79-81)tCc>tAc	p.S27Y		NM_007354.2	NP_031380.1	O15544	GR6_HUMAN	chromosome 3 open reading frame 27	27										large_intestine(2)|lung(5)|prostate(1)	8				GBM - Glioblastoma multiforme(114;0.176)		CTGGAGGCGGGAGACGCTGAG	0.597000													10	34					2.80697e-09	3.22204e-09	1	1	0
MATN2	4147	broad.mit.edu	37	8	98900408	98900408	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr8:98900408C>T	ENST00000254898.5	+	2	311	c.80C>T	c.(79-81)tCa>tTa	p.S27L	MATN2_ENST00000522025.2_Intron|MATN2_ENST00000520016.1_Missense_Mutation_p.S27L|MATN2_ENST00000524308.1_Missense_Mutation_p.S27L|MATN2_ENST00000521689.1_Missense_Mutation_p.S27L	NM_002380.3|NM_030583.2	NP_002371.3|NP_085072.2	O00339	MATN2_HUMAN	matrilin 2	27						proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(2)|urinary_tract(1)	31	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			AGGGAGCGGTCACGTGGGAGG	0.632000													13	15					0	0	1	0	0
C15orf53	400359	broad.mit.edu	37	15	38988836	38988836	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr15:38988836C>A	ENST00000318792.1	+	1	38	c.28C>A	c.(28-30)Ctg>Atg	p.L10M		NM_207444.2	NP_997327.1	Q8NAA6	CO053_HUMAN	chromosome 15 open reading frame 53	10										endometrium(1)|large_intestine(1)|lung(2)|skin(1)|stomach(1)	6		all_cancers(109;1.75e-13)|all_epithelial(112;1.02e-11)|Lung NSC(122;1.9e-09)|all_lung(180;4.04e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;8.39e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0321)		CCAAGAGGACCTGGGCATTTC	0.552000													20	51					1.96292e-10	2.3111e-10	1	1	0
FAT3	120114	broad.mit.edu	37	11	92600140	92600140	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:92600140G>A	ENST00000298047.6	+	21	11909	c.11892G>A	c.(11890-11892)gcG>gcA	p.A3964A	FAT3_ENST00000409404.2_Silent_p.A3964A|FAT3_ENST00000525166.1_Silent_p.A3814A|FAT3_ENST00000533797.1_Silent_p.A299A			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	3964	Laminin G-like.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TGGTGCAAGCGGATAACATCC	0.622000										TCGA Ovarian(4;0.039)			6	23					0	0	1	0	0
USP54	159195	broad.mit.edu	37	10	75286500	75286500	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr10:75286500G>A	ENST00000339859.4	-	15	2199	c.2099C>T	c.(2098-2100)tCc>tTc	p.S700F	USP54_ENST00000497106.1_5'UTR|USP54_ENST00000394811.2_5'UTR|USP54_ENST00000428547.1_Missense_Mutation_p.S550F|USP54_ENST00000408019.1_Missense_Mutation_p.S700F			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	700					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					ATGACGCCAGGAAGGAACCAA	0.493000													7	43					0	0	1	0	0
BOC	91653	broad.mit.edu	37	3	112993415	112993415	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:112993415C>G	ENST00000495514.1	+	9	2132	c.1428C>G	c.(1426-1428)atC>atG	p.I476M	BOC_ENST00000497495.1_3'UTR|BOC_ENST00000355385.3_Missense_Mutation_p.I476M|BOC_ENST00000273395.4_Missense_Mutation_p.I476M			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	476	Fibronectin type-III 1.				cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			AGGCTCCCATCATCCTCAGCT	0.677000													4	57					0	0	1	0	0
LRP10	26020	broad.mit.edu	37	14	23346022	23346022	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr14:23346022A>G	ENST00000359591.4	+	6	2240	c.1549A>G	c.(1549-1551)Aat>Gat	p.N517D	LRP10_ENST00000546834.1_Missense_Mutation_p.N517D|LRP10_ENST00000470660.1_3'UTR	NM_014045.3	NP_054764.2	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein 10	517					endocytosis	coated pit|integral to membrane				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(2)	32	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		AGAGAATCCTAATGATGTAAG	0.582000													17	54					0	0	1	0	0
HPD	3242	broad.mit.edu	37	12	122285119	122285119	+	Splice_Site	SNP	A	A	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:122285119A>T	ENST00000543163.1	-	11	926	c.479_splice	c.e11-1	p.Y161_splice	HPD_ENST00000289004.4_Splice_Site_p.Y200_splice|HPD_ENST00000543869.2_5'UTR	NM_001171993.1	NP_001165464.1	P32754	HPPD_HUMAN	4-hydroxyphenylpyruvate dioxygenase	200					L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	4-hydroxyphenylpyruvate dioxygenase activity|metal ion binding			breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(8)|urinary_tract(1)	18	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000105)|Epithelial(86;0.000352)|BRCA - Breast invasive adenocarcinoma(302;0.225)	Nitisinone(DB00348)	TTTTTCAGGTACCTGTAGGGT	0.567000													18	43					0	0	1	0	0
CSTF2	1478	broad.mit.edu	37	X	100087745	100087745	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:100087745C>G	ENST00000415585.2	+	11	1136	c.1114C>G	c.(1114-1116)Cag>Gag	p.Q372E	CSTF2_ENST00000486615.1_3'UTR|CSTF2_ENST00000372972.2_Missense_Mutation_p.Q352E			P33240	CSTF2_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa	352	Gly/Pro-rich.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(2)|stomach(1)	13						ACCACCTCATCAGGGTCCACC	0.498000													3	21					0	0	1	0	0
TLR8	51311	broad.mit.edu	37	X	12939943	12939943	+	Silent	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:12939943C>A	ENST00000218032.6	+	2	2871	c.2784C>A	c.(2782-2784)atC>atA	p.I928I	TLR8_ENST00000311912.5_Silent_p.I946I	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	928	TIR.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						GATTGGCCATCATCGACAACC	0.423000													31	75					5.45727e-16	6.86656e-16	1	1	0
USP54	159195	broad.mit.edu	37	10	75277238	75277238	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr10:75277238C>T	ENST00000339859.4	-	19	3046	c.2946G>A	c.(2944-2946)gaG>gaA	p.E982E	USP54_ENST00000422491.2_Silent_p.E164E|USP54_ENST00000497106.1_5'UTR|USP54_ENST00000394811.2_Silent_p.E70E|USP54_ENST00000428547.1_Silent_p.E832E|USP54_ENST00000408019.1_Silent_p.E982E|RP11-137L10.6_ENST00000600206.1_RNA|RP11-137L10.6_ENST00000597958.1_RNA|RP11-137L10.6_ENST00000595069.1_RNA|RP11-137L10.6_ENST00000593790.1_RNA			Q70EL1	UBP54_HUMAN	ubiquitin specific peptidase 54	982					ubiquitin-dependent protein catabolic process		protein binding|ubiquitin thiolesterase activity			breast(5)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	30	Prostate(51;0.0112)					GAGAATTCTTCTCAGTCCACC	0.502000													11	40					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152128160	152128160	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:152128160C>A	ENST00000316073.3	-	3	1479	c.1415G>T	c.(1414-1416)aGt>aTt	p.S472I		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	472	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						GTAGTGGGAACTCTGGCCTTG	0.498000													186	1046					4.39737e-88	5.77077e-88	1	1	0
FAM161A	84140	broad.mit.edu	37	2	62066702	62066702	+	Silent	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:62066702A>G	ENST00000404929.1	-	3	1448	c.1437T>C	c.(1435-1437)gaT>gaC	p.D479D	FAM161A_ENST00000405894.3_Silent_p.D479D	NM_001201543.1	NP_001188472.1	Q3B820	F161A_HUMAN	family with sequence similarity 161, member A	479					response to stimulus|visual perception	centrosome				breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						AATTTTCTTCATCTGCTTCGA	0.393000													21	59					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130892270	130892270	+	Splice_Site	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:130892270C>A	ENST00000261655.4	-	16	3089		c.e16+1			NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2							cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		TTGGCTGGTACCTCGACATCG	0.567000													91	248					2.98122e-55	3.90114e-55	1	1	0
GRPEL1	80273	broad.mit.edu	37	4	7062754	7062754	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:7062754C>T	ENST00000264954.4	-	4	653	c.489G>A	c.(487-489)ttG>ttA	p.L163L		NM_025196.2	NP_079472.1	Q9HAV7	GRPE1_HUMAN	GrpE-like 1, mitochondrial (E. coli)	163					protein folding|protein import into mitochondrial matrix	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5						CGACAGGGTTCAACTTGAGCA	0.517000													6	110					0	0	1	0	0
SLC34A2	10568	broad.mit.edu	37	4	25664326	25664326	+	Splice_Site	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:25664326G>T	ENST00000382051.3	+	3	162		c.e3-1		SLC34A2_ENST00000503434.1_Intron|SLC34A2_ENST00000504570.1_Intron	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2						cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				GCTTGTTTCAGCAGATAACAC	0.507000			T	ROS1	NSCLC								10	191					2.80697e-09	3.22204e-09	1	1	0
HAND2	9464	broad.mit.edu	37	4	174449954	174449954	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:174449954C>G	ENST00000359562.4	-	1	1426	c.487G>C	c.(487-489)Gag>Cag	p.E163Q	HAND2_ENST00000505300.1_5'UTR|HAND2-AS1_ENST00000515310.1_RNA|HAND2-AS1_ENST00000512099.1_RNA	NM_021973.2	NP_068808.1	P61296	HAND2_HUMAN	heart and neural crest derivatives expressed 2	163					adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			endometrium(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)	13		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		GCCTCCGCCTCGCCATTCTGG	0.607000													24	40					0	0	1	0	0
AGO2	27161	broad.mit.edu	37	8	141557617	141557617	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr8:141557617C>G	ENST00000220592.5	-	13	1810	c.1698G>C	c.(1696-1698)aaG>aaC	p.K566N	AGO2_ENST00000519980.1_Missense_Mutation_p.K566N	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2																		TGACGTTGATCTTCAGGCAGA	0.647000													7	76					0	0	1	0	0
NUTM2F	54754	broad.mit.edu	37	9	97081023	97081023	+	Silent	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr9:97081023G>C	ENST00000253262.4	-	7	2015	c.1995C>G	c.(1993-1995)ctC>ctG	p.L665L	NUTM2F_ENST00000335456.7_Intron|NUTM2F_ENST00000341207.4_Silent_p.L650L	NM_017561.1	NP_060031.1			NUT family member 2F																		CTCCTGGGCTGAGAAGGCCCG	0.617000													6	4					0	0	1	0	0
ANKMY1	51281	broad.mit.edu	37	2	241452252	241452252	+	Silent	SNP	T	T	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:241452252T>A	ENST00000391987.1	-	10	2211	c.1845A>T	c.(1843-1845)gcA>gcT	p.A615A	ANKMY1_ENST00000361678.4_Silent_p.A474A|ANKMY1_ENST00000403283.1_Silent_p.A553A|ANKMY1_ENST00000373320.4_Silent_p.A385A|ANKMY1_ENST00000401804.1_Silent_p.A704A|ANKMY1_ENST00000272972.3_Silent_p.A615A|ANKMY1_ENST00000406958.1_Silent_p.A376A|ANKMY1_ENST00000536462.1_3'UTR|ANKMY1_ENST00000373318.2_Silent_p.A474A			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	615							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		CCTCGTCGGATGCCTTGGCGT	0.612000													15	32					0	0	1	0	0
SCML4	256380	broad.mit.edu	37	6	108076835	108076835	+	Nonsense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:108076835G>T	ENST00000369021.3	-	1	8	c.9C>A	c.(7-9)tgC>tgA	p.C3*	SCML4_ENST00000369020.3_Intron|SCML4_ENST00000369022.2_Intron			Q8N228	SCML4_HUMAN	sex comb on midleg-like 4 (Drosophila)	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(2)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(1)	25		all_cancers(87;3.26e-06)|Acute lymphoblastic leukemia(125;3.08e-08)|all_hematologic(75;1.15e-06)|all_epithelial(87;0.00142)|Colorectal(196;0.0316)		BRCA - Breast invasive adenocarcinoma(108;0.01)|Epithelial(106;0.0509)|all cancers(137;0.0586)|OV - Ovarian serous cystadenocarcinoma(136;0.0758)		CTGTTCTCTGGCAGGGCATTT	0.423000													12	35					3.03607e-14	3.74804e-14	1	1	0
ISL1	3670	broad.mit.edu	37	5	50685659	50685659	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr5:50685659C>T	ENST00000230658.7	+	4	1243	c.658C>T	c.(658-660)Ctc>Ttc	p.L220F	ISL1_ENST00000511384.1_Missense_Mutation_p.L220F|ISL1_ENST00000505475.2_3'UTR	NM_002202.2	NP_002193.2	P61371	ISL1_HUMAN	ISL LIM homeobox 1	220					generation of precursor metabolites and energy|multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(11)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		Lung NSC(810;0.000845)|Breast(144;0.0411)				GATGACGGGCCTCAGTCCCCG	0.572000													13	26					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197030946	197030946	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:197030946C>G	ENST00000367412.1	-	3	462	c.419G>C	c.(418-420)tGg>tCg	p.W140S		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	140	Sushi 2.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						TTGAGAAGACCATCCATCAGA	0.373000													9	64					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138163244	138163244	+	Silent	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:138163244A>G	ENST00000409968.1	+	13	2740	c.2562A>G	c.(2560-2562)acA>acG	p.T854T	THSD7B_ENST00000272643.3_Silent_p.T854T|THSD7B_ENST00000413152.2_Silent_p.T823T|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TCAAGCAGACAAACGGCATGC	0.458000													15	38					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	406981	406981	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr9:406981G>T	ENST00000432829.2	+	28	3554	c.3238G>T	c.(3238-3240)Gat>Tat	p.D1080Y	DOCK8_ENST00000453981.1_Missense_Mutation_p.D1148Y|DOCK8_ENST00000469391.1_Missense_Mutation_p.D1048Y|DOCK8_ENST00000382329.1_Missense_Mutation_p.D615Y	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1148					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity	p.D1148N(1)|p.D1080N(1)		breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CAGCATGTTCGATCTGACTTC	0.537000													7	81					8.12818e-05	8.57767e-05	1	1	0
MMP11	4320	broad.mit.edu	37	22	24125881	24125881	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr22:24125881G>C	ENST00000598975.1	-	1	264	c.265C>G	c.(265-267)Cat>Gat	p.H89D	MMP11_ENST00000215743.3_3'UTR																							CAACCACCATGACAACTGCCG	0.607000													3	19					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115391348	115391348	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr10:115391348C>T	ENST00000369358.4	-	18	2030	c.1786G>A	c.(1786-1788)Gaa>Aaa	p.E596K	NRAP_ENST00000360478.3_Missense_Mutation_p.E553K|NRAP_ENST00000359988.3_Missense_Mutation_p.E588K|NRAP_ENST00000369360.3_Missense_Mutation_p.E561K			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	588						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TTTGTCTTTTCATATTCTTCT	0.428000													8	74					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138400076	138400076	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:138400076G>T	ENST00000409968.1	+	21	3996	c.3818G>T	c.(3817-3819)cGa>cTa	p.R1273L	THSD7B_ENST00000272643.3_Missense_Mutation_p.R1276L|THSD7B_ENST00000413152.2_Missense_Mutation_p.R1245L|THSD7B_ENST00000543459.1_Intron					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		AGCCGGACTCGATTTATCATT	0.498000													10	114					2.80697e-09	3.22204e-09	1	1	0
THRAP3	9967	broad.mit.edu	37	1	36755327	36755327	+	Silent	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:36755327C>A	ENST00000354618.5	+	5	1931	c.1707C>A	c.(1705-1707)gtC>gtA	p.V569V	THRAP3_ENST00000469141.2_Silent_p.V569V|THRAP3_ENST00000466743.1_3'UTR	NM_005119.3	NP_005110.2	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	569					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(12)|ovary(5)|stomach(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AGGCACAGGTCAATGTCCGGA	0.517000			T	USP6	aneurysmal bone cysts								34	55					9.78485e-24	1.2518e-23	1	1	0
SIGLEC1	6614	broad.mit.edu	37	20	3675114	3675114	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr20:3675114G>A	ENST00000344754.4	-	12	3009	c.3010C>T	c.(3010-3012)Ctg>Ttg	p.L1004L	SIGLEC1_ENST00000202578.4_Silent_p.L1004L	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1004	Ig-like C2-type 10.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						ACACGGCACAGGAGGAGGCCC	0.672000													12	21					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13759023	13759023	+	Silent	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr5:13759023A>G	ENST00000265104.4	-	61	10455	c.10351T>C	c.(10351-10353)Ttg>Ctg	p.L3451L		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3451	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTGTCATCCAACTCGGCCTGG	0.547000									Kartagener syndrome				51	189					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	396816	396816	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr9:396816T>C	ENST00000432829.2	+	25	3114	c.2798T>C	c.(2797-2799)aTg>aCg	p.M933T	DOCK8_ENST00000453981.1_Missense_Mutation_p.M1001T|DOCK8_ENST00000469391.1_Missense_Mutation_p.M901T|DOCK8_ENST00000382331.1_Missense_Mutation_p.M303T|DOCK8_ENST00000382329.1_Missense_Mutation_p.M468T	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1001					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		GTACATAACATGGACAAACGG	0.478000													43	48					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119097321	119097321	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr9:119097321G>A	ENST00000328252.3	+	13	3948	c.3579G>A	c.(3577-3579)caG>caA	p.Q1193Q	PAPPA_ENST00000534838.1_Silent_p.Q231Q	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	1193					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						GCAGCTGCCAGAGAGGGGAGA	0.622000													36	56					0	0	1	0	0
TRIM28	10155	broad.mit.edu	37	19	59060599	59060599	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:59060599A>G	ENST00000253024.5	+	12	1943	c.1654A>G	c.(1654-1656)Att>Gtt	p.I552V	TRIM28_ENST00000341753.6_Missense_Mutation_p.I470V	NM_005762.2	NP_005753.1	Q13263	TIF1B_HUMAN	tripartite motif containing 28	552					epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	nucleoplasm	chromo shadow domain binding|ligase activity|transcription corepressor activity|zinc ion binding			biliary_tract(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TGGCATGGCCATTGTCAAGGT	0.592000													16	123					0	0	1	0	0
STAG2	10735	broad.mit.edu	37	X	123197899	123197899	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chrX:123197899G>C	ENST00000371160.1	+	20	2313	c.2023G>C	c.(2023-2025)Gag>Cag	p.E675Q	STAG2_ENST00000371144.3_Missense_Mutation_p.E675Q|STAG2_ENST00000371145.3_Missense_Mutation_p.E675Q|STAG2_ENST00000371157.3_Missense_Mutation_p.E675Q|STAG2_ENST00000354548.5_Missense_Mutation_p.E606Q|STAG2_ENST00000469481.1_Intron|STAG2_ENST00000218089.9_Missense_Mutation_p.E675Q			Q8N3U4	STAG2_HUMAN	stromal antigen 2	675					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(9)|lung(21)|ovary(5)|prostate(2)|skin(5)|urinary_tract(4)	78						TTTTCTGCAAGAGGTATATAT	0.358000													6	23					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48286094	48286094	+	Missense_Mutation	SNP	T	T	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:48286094T>G	ENST00000320048.1	+	1	682	c.682T>G	c.(682-684)Ttg>Gtg	p.L228V		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	228					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						AAGCCACAACTTGGAGGGGCA	0.532000													8	76					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103379225	103379225	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:103379225C>G	ENST00000358392.2	-	53	4353	c.4036G>C	c.(4036-4038)Gac>Cac	p.D1346H	COL11A1_ENST00000353414.4_Missense_Mutation_p.D1295H|COL11A1_ENST00000370096.3_Missense_Mutation_p.D1334H|COL11A1_ENST00000512756.1_Missense_Mutation_p.D1218H	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1334	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCACCCTTGTCACCACCAACA	0.338000													8	87					0	0	1	0	0
MARCH7	64844	broad.mit.edu	37	2	160585672	160585672	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:160585672G>T	ENST00000259050.3	+	2	261	c.139G>T	c.(139-141)Gat>Tat	p.D47Y	MARCH7_ENST00000473749.1_3'UTR|MARCH7_ENST00000409175.1_Missense_Mutation_p.D47Y|MARCH7_ENST00000539065.1_Missense_Mutation_p.D47Y	NM_022826.2	NP_073737.1	Q9H992	MARH7_HUMAN	membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase	47	Ser-rich.						ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(3)|prostate(1)|skin(1)|stomach(2)	18						ATTTAGATTGGATTCTGAATA	0.358000													5	42					0.0215528	0.0219848	1	1	0
CD19	930	broad.mit.edu	37	16	28943360	28943360	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr16:28943360C>T	ENST00000538922.1	+	1	101	c.39C>T	c.(37-39)ctC>ctT	p.L13L	CD19_ENST00000567541.1_Silent_p.L13L|CD19_ENST00000324662.3_Silent_p.L13L	NM_001178098.1|NM_001770.5	NP_001171569.1|NP_001761.3	P15391	CD19_HUMAN	CD19 molecule	13					cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(4)|urinary_tract(1)	29						TCCTCTTCCTCACCCCCATGG	0.607000													21	82					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71653742	71653742	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:71653742G>A	ENST00000409544.1	+	24	5373	c.4743G>A	c.(4741-4743)aaG>aaA	p.K1581K	ZNF638_ENST00000409407.1_Silent_p.K521K|ZNF638_ENST00000355812.3_3'UTR|ZNF638_ENST00000264447.4_Silent_p.K1581K	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	1581	Poly-Lys.				RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						ACTTAAAGAAGAAAAAGGGGA	0.413000													27	74					0	0	1	0	0
F13B	2165	broad.mit.edu	37	1	197030945	197030945	+	Nonsense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:197030945C>T	ENST00000367412.1	-	3	463	c.420G>A	c.(418-420)tgG>tgA	p.W140*		NM_001994.2	NP_001985.2	P05160	F13B_HUMAN	coagulation factor XIII, B polypeptide	140	Sushi 2.				blood coagulation	extracellular region				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(5)|liver(1)|lung(40)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	66						GTTGAGAAGACCATCCATCAG	0.373000													9	64					0	0	1	0	0
PC	5091	broad.mit.edu	37	11	66638533	66638533	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:66638533T>C	ENST00000393960.1	-	7	904	c.623A>G	c.(622-624)cAc>cGc	p.H208R	PC_ENST00000355677.3_Missense_Mutation_p.H208R|PC_ENST00000393955.2_Missense_Mutation_p.H208R|PC_ENST00000393958.2_Missense_Mutation_p.H208R|PC_ENST00000524491.1_Missense_Mutation_p.H168R	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	208	ATP-grasp.|Biotin carboxylation.				gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	CTCGTAGCTGTGCACCACCCT	0.647000													15	67					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144945687	144945687	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr8:144945687C>T	ENST00000525985.1	-	2	1806	c.1735G>A	c.(1735-1737)Gac>Aac	p.D579N				P58107	EPIPL_HUMAN	epiplakin 1	579						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGGTCCTGGTCGATGATCTCG	0.642000													6	15					0	0	1	0	0
C1orf141	400757	broad.mit.edu	37	1	67559163	67559163	+	Missense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:67559163G>T	ENST00000371007.2	-	8	837	c.728C>A	c.(727-729)aCa>aAa	p.T243K	C1orf141_ENST00000371006.1_Missense_Mutation_p.T243K|C1orf141_ENST00000544837.1_Missense_Mutation_p.T243K	NM_001276351.1	NP_001263280.1	Q5JVX7	CA141_HUMAN	chromosome 1 open reading frame 141	243										NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|skin(1)	18						AATGAAATTTGTTCTTTTATG	0.289000													19	40					5.03518e-11	6.03695e-11	1	1	0
FRG1B	284802	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr20:29628263A>G	ENST00000278882.3	+	6	645	c.265A>G	c.(265-267)Att>Gtt	p.I89V	FRG1B_ENST00000358464.4_Missense_Mutation_p.I89V|FRG1B_ENST00000439954.2_Missense_Mutation_p.I94V														p.I89V(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAGCTGCTTTATTAGATGCAA	0.363000													7	125					0	0	1	0	0
IFNA8	3445	broad.mit.edu	37	9	21409616	21409616	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr9:21409616C>G	ENST00000380205.1	+	1	471	c.441C>G	c.(439-441)ttC>ttG	p.F147L		NM_002170.3	NP_002161.2	P32881	IFNA8_HUMAN	interferon, alpha 8	147					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	9				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.0174)		GGAAATACTTCCAAAGAATCA	0.468000													15	181					0	0	1	0	0
DHX32	55760	broad.mit.edu	37	10	127548252	127548252	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr10:127548252C>G	ENST00000284690.3	-	3	1259	c.769G>C	c.(769-771)Gag>Cag	p.E257Q	DHX32_ENST00000284688.6_Missense_Mutation_p.E257Q	NM_018180.2	NP_060650.2	Q7L7V1	DHX32_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 32	257						mitochondrion|nucleus	ATP binding|helicase activity			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|stomach(1)	29		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AAAATAGACTCAAAAGAATCC	0.388000													36	93					0	0	1	0	0
SNW1	22938	broad.mit.edu	37	14	78197467	78197467	+	Silent	SNP	A	A	T	rs61742193		TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr14:78197467A>T	ENST00000261531.7	-	10	959	c.897T>A	c.(895-897)cgT>cgA	p.R299R	SNW1_ENST00000554775.1_Silent_p.R137R|SLIRP_ENST00000557431.1_Intron|SNW1_ENST00000555761.1_Silent_p.R299R	NM_012245.2	NP_036377.1	Q13573	SNW1_HUMAN	SNW domain containing 1	299	SNW.				negative regulation of transcription, DNA-dependent|nuclear mRNA splicing, via spliceosome|regulation of transcription from RNA polymerase II promoter	catalytic step 2 spliceosome|nucleoplasm	Notch binding			NS(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0291)		CCACAGCTTCACGAGCCTGTT	0.423000													4	67					0	0	1	0	0
MIPEP	4285	broad.mit.edu	37	13	24453417	24453417	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr13:24453417G>A	ENST00000382172.3	-	4	627	c.529C>T	c.(529-531)Cca>Tca	p.P177S		NM_005932.3	NP_005923.2	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase	177					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|liver(1)|lung(12)|prostate(2)|skin(1)	27		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		CTTGTTTCTGGATCAAGGGAA	0.383000													70	91					0	0	1	0	0
AXIN1	8312	broad.mit.edu	37	16	396838	396838	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr16:396838C>A	ENST00000262320.3	-	2	559	c.188G>T	c.(187-189)cGc>cTc	p.R63L	AXIN1_ENST00000481769.1_Intron|AXIN1_ENST00000354866.3_Missense_Mutation_p.R63L	NM_003502.3	NP_003493.1	O15169	AXIN1_HUMAN	axin 1	63					activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			biliary_tract(27)|breast(4)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(20)|liver(81)|lung(5)|ovary(2)|prostate(3)|salivary_gland(7)|skin(5)|stomach(4)|thyroid(41)|upper_aerodigestive_tract(4)|urinary_tract(2)	221		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				CAGATCCGAGCGCCTCGGAGT	0.602000											OREG0003698	type=REGULATORY REGION|Gene=AXIN1|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	13	27					5.50884e-06	6.02159e-06	1	1	0
KNTC1	9735	broad.mit.edu	37	12	123067393	123067393	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:123067393G>A	ENST00000333479.7	+	34	3301	c.3124G>A	c.(3124-3126)Gag>Aag	p.E1042K	KNTC1_ENST00000450485.2_Intron	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1042					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		CATAGCTGCTGAGGTGAGGAG	0.552000													6	20					0	0	1	0	0
MEX3D	399664	broad.mit.edu	37	19	1556669	1556669	+	Silent	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:1556669C>G	ENST00000402693.4	-	2	848	c.849G>C	c.(847-849)cgG>cgC	p.R283R	AC027307.1_ENST00000410788.1_RNA|MEX3D_ENST00000388824.6_Silent_p.R283R	NM_203304.3	NP_976049.3	Q86XN8	MEX3D_HUMAN	mex-3 RNA binding family member D	283	KH 2.				mRNA destabilization|posttranscriptional regulation of gene expression by mRNA localization|regulation of anti-apoptosis	nucleus|perinuclear region of cytoplasm	AU-rich element binding|zinc ion binding	p.R105R(1)		endometrium(1)|lung(3)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCCCACCACCCGGTAGGGCA	0.741000													15	21					0	0	1	0	0
BRPF3	27154	broad.mit.edu	37	6	36169089	36169089	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:36169089G>C	ENST00000357641.6	+	2	1243	c.990G>C	c.(988-990)caG>caC	p.Q330H	BRPF3_ENST00000339717.7_Missense_Mutation_p.Q330H|BRPF3_ENST00000534694.1_Missense_Mutation_p.Q330H|BRPF3_ENST00000534400.1_Missense_Mutation_p.Q330H|BRPF3_ENST00000443324.2_Missense_Mutation_p.Q330H|BRPF3_ENST00000543502.1_Missense_Mutation_p.Q330H	NM_015695.2	NP_056510.2	Q9ULD4	BRPF3_HUMAN	bromodomain and PHD finger containing, 3	330					histone H3 acetylation|platelet activation|platelet degranulation	cytosol|extracellular region|MOZ/MORF histone acetyltransferase complex	protein binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(8)|lung(15)|ovary(1)|prostate(1)|skin(4)|urinary_tract(2)	40						TCTGCAAGCAGAAAGGGCTAG	0.512000													8	30					0	0	1	0	0
GOLIM4	27333	broad.mit.edu	37	3	167754759	167754759	+	Missense_Mutation	SNP	T	T	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:167754759T>G	ENST00000470487.1	-	8	1397	c.708A>C	c.(706-708)caA>caC	p.Q236H	GOLIM4_ENST00000309027.4_Missense_Mutation_p.Q208H	NM_014498.3	NP_055313.1	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	236	Golgi targeting.				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(5)|endometrium(2)|large_intestine(8)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						TATCTTTCAGTTGTTTATATT	0.408000													41	88					0	0	1	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99621376	99621376	+	Nonsense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:99621376C>T	ENST00000324306.6	+	2	481	c.247C>T	c.(247-249)Cag>Tag	p.Q83*	ZKSCAN1_ENST00000535170.1_Intron|ZKSCAN1_ENST00000426572.1_Nonsense_Mutation_p.Q47*	NM_003439.1	NP_003430.1	P17029	ZKSC1_HUMAN	zinc finger with KRAB and SCAN domains 1	83	SCAN box.				viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			ACTTTGTCATCAGTGGCTGCG	0.542000													10	72					0	0	1	0	0
GINM1	116254	broad.mit.edu	37	6	149911935	149911935	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:149911935G>C	ENST00000367419.5	+	8	1075	c.954G>C	c.(952-954)gaG>gaC	p.E318D		NM_138785.3	NP_620140.1			glycoprotein integral membrane 1									p.E318D(1)									ATGGTCCAGAGAAAAGAGCTG	0.378000													9	40					0	0	1	0	0
DSE	29940	broad.mit.edu	37	6	116579790	116579790	+	Nonsense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr6:116579790G>T	ENST00000540275.1	+	2	305	c.184G>T	c.(184-186)Gaa>Taa	p.E62*				Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	0					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		TAATGTTCCGGAAGGCAGCCT	0.587000													4	50					2.56e-06	2.8117e-06	1	1	0
NLRC5	84166	broad.mit.edu	37	16	57059866	57059866	+	Silent	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr16:57059866G>A	ENST00000436936.1	+	6	1236	c.1011G>A	c.(1009-1011)ctG>ctA	p.L337L	NLRC5_ENST00000262510.6_Silent_p.L337L|NLRC5_ENST00000308149.7_Silent_p.L337L|NLRC5_ENST00000539144.1_Silent_p.L337L			Q86WI3	NLRC5_HUMAN	NLR family, CARD domain containing 5	337	NACHT.				defense response to virus|innate immune response|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production|negative regulation of type I interferon-mediated signaling pathway|positive regulation of interferon-gamma-mediated signaling pathway|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type I interferon-mediated signaling pathway|regulation of kinase activity	cytosol|nucleus	ATP binding|protein binding|RNA polymerase II core promoter sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(21)|ovary(8)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	75		all_neural(199;0.225)				GGACCCTCCTGCCTGGCTGCC	0.622000													15	126					0	0	1	0	0
BNC2	54796	broad.mit.edu	37	9	16419526	16419526	+	Missense_Mutation	SNP	A	A	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr9:16419526A>G	ENST00000380672.4	-	7	2818	c.2761T>C	c.(2761-2763)Tat>Cat	p.Y921H	BNC2_ENST00000380667.2_Missense_Mutation_p.Y854H|BNC2_ENST00000545497.1_Missense_Mutation_p.Y826H	NM_017637.5	NP_060107.3	Q6ZN30	BNC2_HUMAN	basonuclin 2	921					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(16)|liver(1)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(50;9.01e-08)		TGGGCACCATATATCTTCACC	0.567000													4	87					0	0	1	0	0
TUBA3D	113457	broad.mit.edu	37	2	132235914	132235914	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:132235914C>A	ENST00000321253.6	+	2	288	c.181C>A	c.(181-183)Cac>Aac	p.H61N		NM_080386.3	NP_525125.2	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	61					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32				BRCA - Breast invasive adenocarcinoma(221;0.13)		AGCTGGCAAGCACGTGCCCAG	0.567000													26	40					1.2476e-16	1.57411e-16	1	1	0
KMT2C	58508	broad.mit.edu	37	7	151945483	151945483	+	Missense_Mutation	SNP	C	C	T	rs77325966		TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:151945483C>T	ENST00000355193.2	-	14	2254	c.2036G>A	c.(2035-2037)aGa>aAa	p.R679K	KMT2C_ENST00000262189.6_Missense_Mutation_p.R679K					lysine (K)-specific methyltransferase 2C																		TGATTCTTCTCTGGATACCAC	0.418000													26	47					0	0	1	0	0
PCSK7	9159	broad.mit.edu	37	11	117100130	117100130	+	Missense_Mutation	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:117100130T>C	ENST00000320934.3	-	3	1061	c.431A>G	c.(430-432)cAc>cGc	p.H144R		NM_004716.2	NP_004707.2	Q16549	PCSK7_HUMAN	proprotein convertase subtilisin/kexin type 7	144	Catalytic.				peptide hormone processing	integral to Golgi membrane	serine-type endopeptidase activity			NS(1)|endometrium(3)|large_intestine(2)|lung(8)|ovary(1)|skin(1)	16	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|Epithelial(105;6.71e-05)|all cancers(92;0.000537)		GTCGTTGAAGTGGACGCTGCG	0.602000			T	IGH@	MLCLS								21	208					0	0	1	0	0
NLRC3	197358	broad.mit.edu	37	16	3613822	3613822	+	RNA	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr16:3613822G>A	ENST00000301749.7	-	0	1521				NLRC3_ENST00000448023.2_RNA|NLRC3_ENST00000419350.2_RNA|NLRC3_ENST00000324659.8_RNA|NLRC3_ENST00000603507.1_RNA|NLRC3_ENST00000359128.5_RNA	NM_178844.2	NP_849172.2	Q7RTR2	NLRC3_HUMAN	NLR family, CARD domain containing 3						I-kappaB kinase/NF-kappaB cascade|negative regulation of NF-kappaB transcription factor activity|T cell activation	cytoplasm	ATP binding			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(1)|liver(1)|lung(16)|ovary(2)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CCTCCCCGCTGAGGGCCATCC	0.667000													27	50					0	0	1	0	0
ABCA9	10350	broad.mit.edu	37	17	66978702	66978702	+	Splice_Site	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:66978702C>G	ENST00000340001.4	-	37	4932		c.e37+1		ABCA9_ENST00000453985.2_Splice_Site|ABCA9_ENST00000370732.2_Splice_Site	NM_080283.3	NP_525022.2	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 9						transport	integral to membrane	ATP binding|ATPase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(21)|lung(35)|ovary(4)|prostate(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	91	Breast(10;1.47e-12)					GTCACTCTTACCTATCTCTAA	0.383000													12	165					0	0	1	0	0
CABYR	26256	broad.mit.edu	37	18	21740026	21740026	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr18:21740026G>A	ENST00000399496.3	+	5	1297	c.1132G>A	c.(1132-1134)Gaa>Aaa	p.E378K	CABYR_ENST00000327201.6_Missense_Mutation_p.E280K|RP11-799B12.4_ENST00000583267.1_lincRNA|CABYR_ENST00000399499.1_Missense_Mutation_p.E378K|CABYR_ENST00000415309.2_Missense_Mutation_p.E220K|CABYR_ENST00000581397.1_Missense_Mutation_p.E378K	NM_012189.2|NM_153769.1	NP_036321.2|NP_722453.1	O75952	CABYR_HUMAN	calcium binding tyrosine-(Y)-phosphorylation regulated	0					ciliary or flagellar motility|signal transduction|sperm capacitation	cytoplasm|cytoskeleton|flagellum|motile cilium|nucleus	calcium ion binding|cAMP-dependent protein kinase regulator activity|enzyme binding|protein heterodimerization activity|SH3 domain binding			breast(1)|endometrium(2)|large_intestine(4)|lung(4)	11	all_cancers(21;9.13e-05)|all_epithelial(16;5.49e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0305)|Ovarian(20;0.17)					AGCAGAAACTGAAAACTGGTA	0.413000													16	77					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30700256	30700256	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr8:30700256C>G	ENST00000256246.2	-	1	6352	c.6278G>C	c.(6277-6279)tGg>tCg	p.W2093S		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	2093										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		CAAATCAAACCAAAGCATACC	0.348000													10	55					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123234828	123234828	+	Missense_Mutation	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr4:123234828G>C	ENST00000264501.4	+	60	10671	c.10298G>C	c.(10297-10299)gGa>gCa	p.G3433A	KIAA1109_ENST00000455637.1_Missense_Mutation_p.G3433A|KIAA1109_ENST00000388738.3_Missense_Mutation_p.G3433A			Q2LD37	K1109_HUMAN	KIAA1109	3433					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						AGAACTACAGGACAAGCAGCA	0.348000													9	52					0	0	1	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64084988	64084988	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:64084988C>G	ENST00000295902.6	-	8	2859	c.2274G>C	c.(2272-2274)caG>caC	p.Q758H	PRICKLE2_ENST00000564377.1_Missense_Mutation_p.Q814H|RP11-129B22.1_ENST00000482609.1_RNA|PRICKLE2-AS1_ENST00000476308.1_RNA	NM_198859.3	NP_942559.1	Q7Z3G6	PRIC2_HUMAN	prickle homolog 2 (Drosophila)	758						cytoplasm|nuclear membrane	zinc ion binding			breast(2)|endometrium(1)|large_intestine(9)|liver(1)|lung(10)|ovary(4)|prostate(2)|skin(2)|stomach(1)	32		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		CAAAGGCATTCTGCAAAGCCA	0.587000													16	45					0	0	1	0	0
MAGI2	9863	broad.mit.edu	37	7	77789517	77789517	+	Nonsense_Mutation	SNP	G	G	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr7:77789517G>T	ENST00000354212.4	-	16	2923	c.2670C>A	c.(2668-2670)taC>taA	p.Y890*	MAGI2_ENST00000522391.1_Nonsense_Mutation_p.Y890*|MAGI2_ENST00000419488.1_Nonsense_Mutation_p.Y876*	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	890						cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TGTAGGTTGCGTAGTCACTGC	0.577000													18	43					1.15919e-05	1.25807e-05	1	1	0
SCN3A	6328	broad.mit.edu	37	2	165984209	165984209	+	Missense_Mutation	SNP	C	C	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:165984209C>G	ENST00000360093.3	-	18	3816	c.3325G>C	c.(3325-3327)Gag>Cag	p.E1109Q	SCN3A_ENST00000283254.7_Missense_Mutation_p.E1109Q|SCN3A_ENST00000409101.3_Missense_Mutation_p.E1060Q	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	1109						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	AAGTCAGACTCTCCAACAGCA	0.363000													22	70					0	0	1	0	0
KCNMB1	3779	broad.mit.edu	37	5	169812349	169812349	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr5:169812349C>A	ENST00000274629.4	-	2	545	c.103G>T	c.(103-105)Gtc>Ttc	p.V35F	KCNMB1_ENST00000521859.1_Missense_Mutation_p.V35F|KCNIP1_ENST00000518527.1_Intron|KCNIP1_ENST00000377360.4_Intron	NM_004137.3	NP_004128.1	Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, beta member 1	35					platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			endometrium(1)|large_intestine(1)|lung(7)|ovary(2)	11	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)		ACAGTCGTGACCAGGATGTAG	0.592000													23	35					9.95505e-16	1.24574e-15	1	1	0
RIPK2	8767	broad.mit.edu	37	8	90777658	90777658	+	Silent	SNP	T	T	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr8:90777658T>C	ENST00000220751.4	+	3	731	c.417T>C	c.(415-417)acT>acC	p.T139T	RIPK2_ENST00000540020.1_Silent_p.T2T	NM_003821.5	NP_003812.1	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	139	Protein kinase.				activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			kidney(1)|large_intestine(3)|lung(2)|ovary(2)|prostate(2)	10			BRCA - Breast invasive adenocarcinoma(11;0.0474)			ACAATATGACTCCTCCTTTAC	0.333000													54	90					0	0	1	0	0
SMARCA4	6597	broad.mit.edu	37	19	11145722	11145722	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:11145722G>A	ENST00000358026.2	+	29	4368	c.4084G>A	c.(4084-4086)Gag>Aag	p.E1362K	SMARCA4_ENST00000589677.1_Missense_Mutation_p.E1329K|SMARCA4_ENST00000429416.3_Missense_Mutation_p.E1362K|SMARCA4_ENST00000450717.3_Missense_Mutation_p.E1329K|SMARCA4_ENST00000541122.2_Missense_Mutation_p.E1329K|SMARCA4_ENST00000444061.3_Missense_Mutation_p.E1329K|SMARCA4_ENST00000590574.1_Missense_Mutation_p.E1329K|SMARCA4_ENST00000413806.3_Missense_Mutation_p.E1329K|SMARCA4_ENST00000344626.4_Missense_Mutation_p.E1362K	NM_001128849.1	NP_001122321.1	P51532	SMCA4_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	1362	Poly-Glu.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		adrenal_gland(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(23)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|liver(4)|lung(60)|ovary(10)|pancreas(7)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	163		all_lung(6;0.0512)|Lung NSC(9;0.0568)				CTGTGAGGAGGAGGAGGAGAA	0.637000			"""F, N, Mis"""		NSCLC								7	8					0	0	1	0	0
SLC40A1	30061	broad.mit.edu	37	2	190428487	190428487	+	Nonsense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:190428487G>A	ENST00000261024.2	-	7	1651	c.1225C>T	c.(1225-1227)Cga>Tga	p.R409*		NM_014585.5	NP_055400.1	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated transporter), member 1	409					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			AACCTTGATCGGATATCTTCA	0.408000													6	85					0	0	1	0	0
AP3D1	8943	broad.mit.edu	37	19	2102190	2102190	+	Silent	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:2102190C>T	ENST00000355272.6	-	32	3836	c.3630G>A	c.(3628-3630)gcG>gcA	p.A1210A	AP3D1_ENST00000356926.4_Silent_p.A1107A|AP3D1_ENST00000345016.5_Silent_p.A1148A|AP3D1_ENST00000350812.6_Silent_p.A979A	NM_001261826.1	NP_001248755.1	O14617	AP3D1_HUMAN	adaptor-related protein complex 3, delta 1 subunit	1148					eye pigment biosynthetic process|intracellular protein transport|regulation of sequestering of zinc ion|vesicle-mediated transport	endosome membrane|Golgi membrane|membrane coat	binding|protein transporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(23)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGCCAGCGTCGCCTTCATCT	0.587000													28	120					0	0	1	0	0
SLC6A2	6530	broad.mit.edu	37	16	55690762	55690762	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr16:55690762C>A	ENST00000379906.2	+	1	411	c.156C>A	c.(154-156)gaC>gaA	p.D52E	SLC6A2_ENST00000414754.3_Missense_Mutation_p.D52E|SLC6A2_ENST00000568943.1_Missense_Mutation_p.D52E|SLC6A2_ENST00000561820.1_Missense_Mutation_p.D52E|SLC6A2_ENST00000219833.8_Missense_Mutation_p.D52E|SLC6A2_ENST00000566163.1_Missense_Mutation_p.D52E	NM_001043.3	NP_001034.1	P23975	SC6A2_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 2	52					synaptic transmission	integral to plasma membrane|membrane fraction	norepinephrine:sodium symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(3)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(181;0.01)|Kidney(780;0.0267)	Amineptine(DB04836)|Amitriptyline(DB00321)|Amoxapine(DB00543)|Atomoxetine(DB00289)|Bethanidine(DB00217)|Bupropion(DB01156)|Clomipramine(DB01242)|Cocaine(DB00907)|Debrisoquin(DB04840)|Desipramine(DB01151)|Diethylpropion(DB00937)|Doxepin(DB01142)|Duloxetine(DB00476)|Ergotamine(DB00696)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Imipramine(DB00458)|Maprotiline(DB00934)|Mazindol(DB00579)|Methylphenidate(DB00422)|Milnacipran(DB04896)|Nefazodone(DB01149)|Norepinephrine(DB00368)|Nortriptyline(DB00540)|Paroxetine(DB00715)|Phenmetrazine(DB00830)|Phentermine(DB00191)|Protriptyline(DB00344)|Reboxetine(DB00234)|Sibutramine(DB01105)|Tramadol(DB00193)|Trazodone(DB00656)|Trimipramine(DB00726)|Venlafaxine(DB00285)	GCGACGGCGACGCGCAGCCCC	0.687000													31	81					2.61193e-14	3.23315e-14	1	1	0
KCTD19	146212	broad.mit.edu	37	16	67333384	67333384	+	Missense_Mutation	SNP	C	C	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr16:67333384C>A	ENST00000304372.5	-	6	923	c.868G>T	c.(868-870)Gcc>Tcc	p.A290S	KCTD19_ENST00000562860.1_5'UTR	NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	290						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		AGACCCAGGGCCATTGTGTAG	0.637000													32	135					7.11191e-15	8.85123e-15	1	1	0
EHF	26298	broad.mit.edu	37	11	34673102	34673102	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:34673102G>A	ENST00000257831.3	+	5	541	c.420G>A	c.(418-420)atG>atA	p.M140I	EHF_ENST00000531794.1_Missense_Mutation_p.M162I|EHF_ENST00000450654.2_Missense_Mutation_p.M140I|EHF_ENST00000533754.1_Missense_Mutation_p.M140I|EHF_ENST00000530286.1_Missense_Mutation_p.M140I	NM_012153.5	NP_036285.2	Q9NZC4	EHF_HUMAN	ets homologous factor	140					cell proliferation|epithelial cell differentiation|multicellular organismal development|positive regulation of transcription, DNA-dependent		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		NFIA/EHF(2)	autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|lung(8)|upper_aerodigestive_tract(1)	17		all_hematologic(20;0.117)	Epithelial(1;0.055)|all cancers(1;0.137)|STAD - Stomach adenocarcinoma(6;0.235)			CTTCCATCATGAACACCTGGA	0.408000													10	79					0	0	1	0	0
DNAJC10	54431	broad.mit.edu	37	2	183582879	183582879	+	Silent	SNP	G	G	C			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:183582879G>C	ENST00000264065.6	+	3	481	c.66G>C	c.(64-66)ctG>ctC	p.L22L	DNAJC10_ENST00000537515.1_Silent_p.L22L|DNAJC10_ENST00000469118.1_Intron	NM_018981.1	NP_061854.1	Q8IXB1	DJC10_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 10	22					apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|ER-associated protein catabolic process|glycerol ether metabolic process|negative regulation of protein phosphorylation|protein folding|response to endoplasmic reticulum stress	endoplasmic reticulum chaperone complex|endoplasmic reticulum lumen|extracellular region	ATPase activator activity|ATPase binding|chaperone binding|electron carrier activity|heat shock protein binding|misfolded protein binding|protein disulfide oxidoreductase activity|unfolded protein binding			breast(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(15)|ovary(1)|skin(1)	32			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TCTGTTTTCTGATAGTGTATA	0.358000													5	72					0	0	1	0	0
G6PC	2538	broad.mit.edu	37	17	41063288	41063288	+	Missense_Mutation	SNP	C	C	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr17:41063288C>T	ENST00000253801.2	+	5	998	c.919C>T	c.(919-921)Cac>Tac	p.H307Y	G6PC_ENST00000585489.1_3'UTR|G6PC_ENST00000592383.1_3'UTR	NM_000151.3	NP_000142.2	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	307					gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		CGTCCTCCTGCACGTCTTTGA	0.567000													19	161					0	0	1	0	0
INO80	54617	broad.mit.edu	37	15	41276098	41276098	+	Missense_Mutation	SNP	G	G	A			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr15:41276098G>A	ENST00000361937.3	-	34	4523	c.4099C>T	c.(4099-4101)Cac>Tac	p.H1367Y	INO80_ENST00000401393.3_Missense_Mutation_p.H1367Y			Q9ULG1	INO80_HUMAN	INO80 complex subunit	1367	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			NS(1)|breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						GAGCCAGTGTGCAGCTCACTG	0.567000													4	56					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803275	142803276	+	RNA	INS	-	-	AAC	rs145869340		TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr1:142803275_142803276insAAC	ENST00000423385.1	-	0	1689_1690																											AACCAAACCAAaacaacaacaa	0.342													3	3	---	---	---	---					
NFE2L2	4780	broad.mit.edu	37	2	178098936	178098944	+	In_Frame_Del	DEL	ATACTTCTC	ATACTTCTC	-			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr2:178098936_178098944delATACTTCTC	ENST00000397062.3	-	2	655_663	c.101_109delGAGAAGTAT	c.(100-111)ctt>c	p.REVF34del	NFE2L2_ENST00000464747.1_In_Frame_Del_p.REVF18del|NFE2L2_ENST00000446151.2_In_Frame_Del_p.REVF18del|NFE2L2_ENST00000423513.1_In_Frame_Del_p.REVF18del|NFE2L2_ENST00000397063.4_In_Frame_Del_p.REVF18del	NM_006164.4	NP_006155.2	Q16236	NF2L2_HUMAN	nuclear factor, erythroid 2-like 2	34					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R34Q(10)|p.R34P(2)|p.V36_F37insSREV(1)		central_nervous_system(1)|cervix(4)|endometrium(14)|kidney(5)|large_intestine(4)|liver(13)|lung(71)|oesophagus(29)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	158			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			CTGAAGTCAAATACTTCTCGACTTACTCC	0.373			Mis		"""NSCLC, HNSCC"""					HNSCC(56;0.16)			15	38	---	---	---	---					
PRKCD	5580	broad.mit.edu	37	3	53223163	53223163	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:53223163delC	ENST00000394729.2	+	16	1972	c.1644delC	c.(1642-1644)ttfs	p.F548fs	PRKCD_ENST00000330452.3_Frame_Shift_Del_p.F548fs	NM_212539.1	NP_997704.1	Q05655	KPCD_HUMAN	protein kinase C, delta	548	Protein kinase.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			breast(1)|central_nervous_system(4)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		AGTCCCCCTTCCATGGTGATG	0.557													11	30	---	---	---	---					
SEC61A1	29927	broad.mit.edu	37	3	127774424	127774424	+	Splice_Site	DEL	G	G	-			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr3:127774424delG	ENST00000243253.3	+	3	325	c.141_splice	c.e3+1	p.Q47_splice	SEC61A1_ENST00000424880.2_Intron|SEC61A1_ENST00000464451.1_Splice_Site_p.Q53_splice	NM_013336.3	NP_037468.1	P61619	S61A1_HUMAN	Sec61 alpha 1 subunit (S. cerevisiae)	47					protein targeting to ER	integral to endoplasmic reticulum membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein binding|ribosome binding			central_nervous_system(1)|kidney(1)|large_intestine(5)|liver(1)|lung(8)|ovary(1)|prostate(4)	21						TGTGCTGCCAGGTAAGCTCAG	0.478													61	168	---	---	---	---					
RB1CC1	9821	broad.mit.edu	37	8	53569599	53569600	+	Frame_Shift_Ins	INS	-	-	T			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr8:53569599_53569600insT	ENST00000025008.5	-	15	3312_3313	c.2789_2790insA	c.(2788-2790)agafs	p.R930fs	RB1CC1_ENST00000435644.2_Frame_Shift_Ins_p.R930fs|RB1CC1_ENST00000539297.1_Frame_Shift_Ins_p.R930fs|RB1CC1_ENST00000521611.1_Intron	NM_014781.4	NP_055596.3	Q8TDY2	RBCC1_HUMAN	RB1-inducible coiled-coil 1	930					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			NS(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(19)|ovary(8)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	60		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				ACTTCTGATCCTTTTCATTCTG	0.327													9	100	---	---	---	---					
ZNF33B	7582	broad.mit.edu	37	10	43088750	43088750	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr10:43088750delC	ENST00000359467.3	-	5	1762	c.1648delG	c.(1648-1650)agfs	p.E550fs	ZNF33B_ENST00000486187.1_RNA	NM_006955.1	NP_008886.1	Q06732	ZN33B_HUMAN	zinc finger protein 33B	550						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(15)|skin(1)|stomach(1)	29						AAGGGTTTCTCCCCTGTGTGC	0.423													24	109	---	---	---	---					
LOC101927708	101927708	broad.mit.edu	37	11	3552650	3552651	+	RNA	INS	-	-	G	rs34642454		TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr11:3552650_3552651insG	ENST00000527970.1	-	0	285																											CAGCACCCCATGGGGGGGCCCT	0.500													5	2	---	---	---	---					
LUM	4060	broad.mit.edu	37	12	91502271	91502271	+	Frame_Shift_Del	DEL	G	G	-			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr12:91502271delG	ENST00000266718.4	-	2	940	c.486delC	c.(484-486)acfs	p.T162fs	LUM_ENST00000548071.1_Intron	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	162					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						GATGGATGAAGGTCAGGTTTA	0.453													22	66	---	---	---	---					
HEATR5A	25938	broad.mit.edu	37	14	31855664	31855664	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr14:31855664delC	ENST00000543095.2	-	9	1491	c.1307delG	c.(1306-1308)gcfs	p.G436fs	HEATR5A_ENST00000389961.3_Frame_Shift_Del_p.G430fs|HEATR5A_ENST00000439727.1_Frame_Shift_Del_p.G143fs|HEATR5A_ENST00000439348.1_Frame_Shift_Del_p.G430fs|HEATR5A_ENST00000404677.3_Frame_Shift_Del_p.G436fs	NM_015473.3	NP_056288.2	Q86XA9	HTR5A_HUMAN	HEAT repeat containing 5A	430							binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)	26	Hepatocellular(127;0.0877)|Breast(36;0.137)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.0797)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0059)		CGCTGTGGTGCCAAGATTGTG	0.438													15	39	---	---	---	---					
SLC24A4	123041	broad.mit.edu	37	14	92949061	92949080	+	Frame_Shift_Del	DEL	GCCCCTCATCTTCCTCCTGT	GCCCCTCATCTTCCTCCTGT	-			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr14:92949061_92949080delGCCCCTCATCTTCCTCCTGT	ENST00000532405.1	+	13	1519_1538	c.1293_1312delGCCCCTCATCTTCCTCCTGT	c.(1291-1314)tggcfs	p.WPLIFLLC431fs	SLC24A4_ENST00000393265.2_Frame_Shift_Del_p.WPLIFLLC367fs|SLC24A4_ENST00000351924.5_Frame_Shift_Del_p.WPLIFLLC395fs|SLC24A4_ENST00000531433.1_Frame_Shift_Del_p.WPLIFLLC412fs|SLC24A4_ENST00000298877.1_Frame_Shift_Del_p.WPLIFLLC414fs			Q8NFF2	NCKX4_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 4	431						integral to membrane|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(20)|ovary(2)|skin(1)	36		all_cancers(154;0.0347)|all_epithelial(191;0.163)		Colorectal(1;0.00242)|COAD - Colon adenocarcinoma(157;0.047)|Epithelial(152;0.0781)|READ - Rectum adenocarcinoma(1;0.176)|all cancers(159;0.182)		TGTTCACCTGGCCCCTCATCTTCCTCCTGTGCGTCACCAT	0.573													17	71	---	---	---	---					
TECPR2	9895	broad.mit.edu	37	14	102912215	102912216	+	Frame_Shift_Ins	INS	-	-	G			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr14:102912215_102912216insG	ENST00000359520.7	+	13	3232_3233	c.3006_3007insG	c.(3004-3009)caggaafs	p.E1003fs	TECPR2_ENST00000558678.1_Frame_Shift_Ins_p.E1003fs	NM_014844.3	NP_055659.2	O15040	TCPR2_HUMAN	tectonin beta-propeller repeat containing 2	1003							protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(21)|ovary(2)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	50						TGGACATCCATGGGAACCTGTG	0.550													23	74	---	---	---	---					
ZBTB14	7541	broad.mit.edu	37	18	5291358	5291358	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr18:5291358delC	ENST00000357006.4	-	4	1187	c.849delG	c.(847-849)ggfs	p.G283fs	ZBTB14_ENST00000400143.3_Frame_Shift_Del_p.G283fs	NM_001143823.2|NM_001243704.1	NP_001137295.1|NP_001230633.1			zinc finger and BTB domain containing 14																		AAAACGTCTTCCCACACGCCT	0.498													21	63	---	---	---	---					
ZNF584	201514	broad.mit.edu	37	19	58928974	58928974	+	Frame_Shift_Del	DEL	C	C	-			TCGA-J2-A4AD-01A-11D-A24D-08	TCGA-J2-A4AD-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25a1fc62-edd0-4af7-87bc-68793893d79c	c6ae72c6-674d-4beb-9b91-a20be4634410	g.chr19:58928974delC	ENST00000306910.4	+	4	1612	c.1089delC	c.(1087-1089)ttfs	p.F363fs	ZNF584_ENST00000599238.1_3'UTR|ZNF584_ENST00000593920.1_Frame_Shift_Del_p.F318fs	NM_173548.1	NP_775819.1	Q8IVC4	ZN584_HUMAN	zinc finger protein 584	363					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(3)|large_intestine(3)|lung(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14		all_cancers(17;5.3e-17)|all_epithelial(17;3.71e-12)|Lung NSC(17;8.3e-05)|Colorectal(82;0.000147)|all_lung(17;0.000386)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0271)		GGAAAACCTTCACTACCAGAT	0.517													21	22	---	---	---	---					
