Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NEUROG2	63973	broad.mit.edu	37	4	113436004	113436004	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr4:113436004G>A	ENST00000313341.3	-	2	954	c.628C>T	c.(628-630)Ccc>Tcc	p.P210S		NM_024019.3	NP_076924.1	Q9H2A3	NGN2_HUMAN	neurogenin 2	210	Ser-rich.				positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent	nucleus	E-box binding			central_nervous_system(1)|large_intestine(3)|lung(6)|skin(2)	12		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00168)		GTGGAGGCGGGCGAGGGGCTG	0.721000													3	13					0	0	1	0	0
C8orf33	65265	broad.mit.edu	37	8	146278517	146278517	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr8:146278517C>T	ENST00000331434.6	+	3	502	c.388C>T	c.(388-390)Ccc>Tcc	p.P130S		NM_023080.2	NP_075568.1	Q9H7E9	CH033_HUMAN	chromosome 8 open reading frame 33	130										endometrium(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7	all_cancers(97;8.72e-12)|all_epithelial(106;1.07e-10)|Lung NSC(106;7.18e-05)|all_lung(105;0.00021)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;9.1e-38)|all cancers(56;7.37e-33)|BRCA - Breast invasive adenocarcinoma(115;0.0424)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.243)		GAGGCAGAAACCCACCCCGAA	0.572000													8	130					0	0	1	0	0
SMTNL2	342527	broad.mit.edu	37	17	4500520	4500520	+	Silent	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr17:4500520C>T	ENST00000389313.4	+	7	1228	c.1161C>T	c.(1159-1161)tgC>tgT	p.C387C	SMTNL2_ENST00000338859.4_Silent_p.C243C	NM_001114974.1	NP_001108446.1	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2	387	CH.									breast(1)|endometrium(9)|kidney(1)|lung(1)|skin(1)	13				READ - Rectum adenocarcinoma(115;0.0325)		TGGCCTTCTGCGCCCTGGTAC	0.622000													17	67					0	0	1	0	0
EIF4B	1975	broad.mit.edu	37	12	53427591	53427591	+	Splice_Site	SNP	T	T	C			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr12:53427591T>C	ENST00000262056.9	+	9	1307	c.979_splice	c.e9-1	p.G327_splice	EIF4B_ENST00000416762.3_Splice_Site_p.G288_splice|EIF4B_ENST00000420463.3_Splice_Site_p.G327_splice|RP11-983P16.4_ENST00000552905.1_RNA	NM_001417.4	NP_001408.2	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	327	Arg-rich.				insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)	22						TTAACTTAGGTCCCCCCCAAA	0.428000													11	23					0	0	1	0	0
AJAP1	55966	broad.mit.edu	37	1	4772619	4772619	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:4772619C>T	ENST00000378191.4	+	2	1070	c.689C>T	c.(688-690)aCg>aTg	p.T230M	AJAP1_ENST00000378190.3_Missense_Mutation_p.T230M	NM_018836.3	NP_061324.1	Q9UKB5	AJAP1_HUMAN	adherens junctions associated protein 1	230	Thr-rich.				cell adhesion	adherens junction|apical plasma membrane|basolateral plasma membrane|integral to membrane				endometrium(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|urinary_tract(1)	24	all_cancers(77;0.071)|Ovarian(185;0.0721)	all_cancers(23;1.77e-36)|all_epithelial(116;1.26e-21)|all_lung(118;3.51e-08)|Lung NSC(185;3.47e-06)|all_neural(13;8.84e-06)|all_hematologic(16;7.61e-05)|Breast(487;0.000507)|Renal(390;0.0007)|Colorectal(325;0.00117)|Hepatocellular(190;0.0071)|Glioma(11;0.0155)|Myeloproliferative disorder(586;0.0258)|Ovarian(437;0.0409)|Lung SC(97;0.133)|Medulloblastoma(700;0.215)		Epithelial(90;3.89e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.97e-19)|GBM - Glioblastoma multiforme(42;3.71e-19)|Colorectal(212;4.57e-06)|COAD - Colon adenocarcinoma(227;0.00019)|Kidney(185;0.000969)|BRCA - Breast invasive adenocarcinoma(365;0.00122)|STAD - Stomach adenocarcinoma(132;0.00578)|KIRC - Kidney renal clear cell carcinoma(229;0.0126)|READ - Rectum adenocarcinoma(331;0.0689)		acccccaTGACGCTGCAGACT	0.622000													10	40					0	0	1	0	0
ZNF479	90827	broad.mit.edu	37	7	57194319	57194319	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr7:57194319T>A	ENST00000331162.4	-	3	416	c.146A>T	c.(145-147)tAc>tTc	p.Y49F		NM_033273.1	NP_150376.1	Q96JC4	ZN479_HUMAN	zinc finger protein 479	49	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(53)|ovary(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	84			GBM - Glioblastoma multiforme(1;9.18e-12)			CAGGTTTCTGTAGTTCTCTAA	0.378000													22	107					0	0	1	0	0
ZNF432	9668	broad.mit.edu	37	19	52537030	52537030	+	Silent	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr19:52537030G>A	ENST00000594154.1	-	5	2114	c.1902C>T	c.(1900-1902)ttC>ttT	p.F634F	ZNF432_ENST00000221315.5_Silent_p.F634F			O94892	ZN432_HUMAN	zinc finger protein 432	634					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	29		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.0054)|OV - Ovarian serous cystadenocarcinoma(262;0.0182)		TCTTTGAGGAGAAGGCTTTTC	0.413000													18	179					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713773	142713773	+	RNA	SNP	C	C	G			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:142713773C>G	ENST00000369381.2	-	0	832																											TCTTTTTCCACATTGTCATTT	0.284000													5	76					0	0	1	0	0
PCDHB15	56121	broad.mit.edu	37	5	140626789	140626789	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr5:140626789G>A	ENST00000231173.3	+	1	1643	c.1643G>A	c.(1642-1644)cGa>cAa	p.R548Q		NM_018935.2	NP_061758.1	Q9Y5E8	PCDBF_HUMAN		548	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(8)|kidney(3)|large_intestine(14)|liver(1)|lung(18)|ovary(3)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	61			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCGCTGGTGCGAGTGCTGGTG	0.711000													21	70					0	0	1	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52715982	52715982	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr19:52715982C>T	ENST00000322088.6	+	5	605	c.547C>T	c.(547-549)Cgg>Tgg	p.R183W	PPP2R1A_ENST00000444322.2_Missense_Mutation_p.R128W|PPP2R1A_ENST00000462990.1_Missense_Mutation_p.R4W	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	183	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity	p.R183W(22)|p.R183G(2)		NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		CATGGTGCGGCGGGCCGCAGC	0.617000			Mis		clear cell ovarian carcinoma								35	56					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176668716	176668716	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:176668716T>C	ENST00000367662.3	+	8	4391	c.3227T>C	c.(3226-3228)tTc>tCc	p.F1076S		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1076					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						CACAGGAAGTTCACGGACGTG	0.547000													14	158					0	0	1	0	0
TRIM2	23321	broad.mit.edu	37	4	154216475	154216475	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr4:154216475C>A	ENST00000338700.5	+	6	862	c.797C>A	c.(796-798)tCg>tAg	p.S266*	TRIM2_ENST00000437508.2_Nonsense_Mutation_p.S239*|TRIM2_ENST00000494872.1_3'UTR	NM_015271.3	NP_056086.2	Q9C040	TRIM2_HUMAN	tripartite motif containing 2	239						cytoplasm	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|prostate(1)	19	all_hematologic(180;0.093)	Medulloblastoma(177;0.00225)		GBM - Glioblastoma multiforme(119;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0703)		GTCCTCCAGTCGCAGCTGGAT	0.647000													8	13					0.00307968	0.00320287	1	1	0
EMR2	30817	broad.mit.edu	37	19	14862341	14862341	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr19:14862341T>A	ENST00000315576.3	-	16	2382	c.1931A>T	c.(1930-1932)aAg>aTg	p.K644M	EMR2_ENST00000596991.2_Missense_Mutation_p.K633M|EMR2_ENST00000594294.1_Missense_Mutation_p.K595M|EMR2_ENST00000594076.1_Missense_Mutation_p.K551M|EMR2_ENST00000392964.3_3'UTR|EMR2_ENST00000392965.3_Missense_Mutation_p.K586M|EMR2_ENST00000353876.1_Missense_Mutation_p.K551M|EMR2_ENST00000353005.1_Missense_Mutation_p.K502M|EMR2_ENST00000595839.1_Missense_Mutation_p.K502M|EMR2_ENST00000392967.2_Missense_Mutation_p.K633M|EMR2_ENST00000601345.1_Missense_Mutation_p.K633M|EMR2_ENST00000346057.1_Missense_Mutation_p.K595M	NM_013447.2	NP_038475.2	Q9UHX3	EMR2_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 2	644					cell adhesion|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	48						CATGAGCTTCTTCATGAATCT	0.557000													12	121					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10952925	10952925	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr21:10952925G>T	ENST00000298232.7	-	8	585	c.218C>A	c.(217-219)tCc>tAc	p.S73Y	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.S53Y|TPTE_ENST00000361285.4_Missense_Mutation_p.S91Y	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	91					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AAATGCAAAGGATGATACAAT	0.348000													12	78					3.41278e-10	3.81645e-10	1	1	0
ZNF341	84905	broad.mit.edu	37	20	32369123	32369123	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr20:32369123C>T	ENST00000375200.1	+	11	2014	c.1649C>T	c.(1648-1650)tCc>tTc	p.S550F	ZNF341_ENST00000342427.2_Missense_Mutation_p.S543F			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	550					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						AACAAATACTCCACCCCTGAG	0.602000													19	216					0	0	1	0	0
CRLF1	9244	broad.mit.edu	37	19	18710390	18710390	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr19:18710390A>C	ENST00000392386.3	-	2	575	c.382T>G	c.(382-384)Tgc>Ggc	p.C128G		NM_004750.4	NP_004741.1	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1	128	Ig-like C2-type.				negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	9						ACATAGAGGCAGGAGCCAGCC	0.642000													3	38					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29451802	29451802	+	Silent	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr2:29451802G>A	ENST00000389048.3	-	16	3669	c.2763C>T	c.(2761-2763)ttC>ttT	p.F921F	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	921	Gly-rich.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	CACCCCCTCCGAAACCCCCTC	0.592000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				9	31					0	0	1	0	0
IGFBP3	3486	broad.mit.edu	37	7	45954501	45954501	+	Missense_Mutation	SNP	A	A	G	rs45490491		TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr7:45954501A>G	ENST00000275521.6	-	4	927	c.794T>C	c.(793-795)gTg>gCg	p.V265A	IGFBP3_ENST00000381083.4_Missense_Mutation_p.V271A|IGFBP3_ENST00000381086.5_Missense_Mutation_p.V168A	NM_000598.4|NM_001013398.1	NP_000589.2|NP_001013416.1	P17936	IBP3_HUMAN	insulin-like growth factor binding protein 3	265	Thyroglobulin type-1.				negative regulation of protein phosphorylation|negative regulation of signal transduction|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of apoptosis|positive regulation of myoblast differentiation|protein phosphorylation|regulation of cell growth	nucleus	insulin-like growth factor I binding|metal ion binding|protein tyrosine phosphatase activator activity			large_intestine(6)|lung(7)|pancreas(1)|prostate(3)	17					Mecasermin(DB01277)	ATACTTATCCACACACCAGCA	0.582000													16	49					0	0	1	0	0
DGKH	160851	broad.mit.edu	37	13	42748264	42748264	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr13:42748264C>T	ENST00000379274.2	+	12	1457	c.1028C>T	c.(1027-1029)gCa>gTa	p.A343V	DGKH_ENST00000498255.2_3'UTR|DGKH_ENST00000538674.1_Missense_Mutation_p.A234V|DGKH_ENST00000261491.4_Missense_Mutation_p.A479V|DGKH_ENST00000540693.1_Missense_Mutation_p.A479V|DGKH_ENST00000337343.4_Missense_Mutation_p.A479V|DGKH_ENST00000536612.1_Missense_Mutation_p.A343V			Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta	479	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(11)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		CCTCCAGAAGCATCTGAAGAA	0.373000													19	87					0	0	1	0	0
TBC1D2	55357	broad.mit.edu	37	9	101014136	101014136	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr9:101014136G>A	ENST00000375066.5	-	2	533	c.442C>T	c.(442-444)Ccg>Tcg	p.P148S	TBC1D2_ENST00000375064.1_Missense_Mutation_p.P148S|TBC1D2_ENST00000342112.5_Intron	NM_018421.3	NP_060891.3	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	148	Interaction with CADH1.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(7)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		GGTGCCGGCGGGCTGTTGTGG	0.627000													5	87					0	0	1	0	0
GUF1	60558	broad.mit.edu	37	4	44682821	44682821	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr4:44682821G>A	ENST00000281543.5	+	3	582	c.388G>A	c.(388-390)Gaa>Aaa	p.E130K	GUF1_ENST00000506793.1_3'UTR	NM_021927.2	NP_068746.2	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog (S. cerevisiae)	130					translation	mitochondrial inner membrane	GTP binding|GTPase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19						TTACAATTGTGAAGGAAAGCA	0.328000													6	52					0	0	1	0	0
MADD	8567	broad.mit.edu	37	11	47311440	47311440	+	Nonsense_Mutation	SNP	G	G	T	rs71475907		TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr11:47311440G>T	ENST00000342922.4	+	17	3136	c.2779G>T	c.(2779-2781)Gag>Tag	p.E927*	MADD_ENST00000406482.1_Nonsense_Mutation_p.E884*|MADD_ENST00000402192.2_Nonsense_Mutation_p.E927*|MADD_ENST00000395344.3_Nonsense_Mutation_p.E884*|MADD_ENST00000349238.3_Nonsense_Mutation_p.E947*|MADD_ENST00000395336.3_Nonsense_Mutation_p.E947*|MADD_ENST00000311027.5_Nonsense_Mutation_p.E947*|MADD_ENST00000402799.1_Nonsense_Mutation_p.E884*|MADD_ENST00000407859.3_Nonsense_Mutation_p.E904*	NM_130470.2	NP_569826.2	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain	947					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			breast(7)|central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(19)|lung(26)|ovary(6)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	84				Lung(87;0.182)		GTTCCTGAAGGAGGTGGTGCA	0.587000													13	31					4.3838e-07	4.79911e-07	1	1	0
GRIN2B	2904	broad.mit.edu	37	12	13716483	13716483	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr12:13716483G>A	ENST00000279593.3	-	13	3898	c.3689C>T	c.(3688-3690)aCg>aTg	p.T1230M		NM_000834.3	NP_000825.2	Q13224	NMDE2_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2B	1230					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(12)|liver(1)|lung(70)|ovary(4)|prostate(6)|skin(10)|upper_aerodigestive_tract(5)|urinary_tract(1)	143					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GTTCTGACCCGTCACCGTCGT	0.602000													5	84					0	0	1	0	0
AKAP1	8165	broad.mit.edu	37	17	55193488	55193488	+	Silent	SNP	C	C	T	rs61731972	byFrequency	TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr17:55193488C>T	ENST00000337714.3	+	7	2531	c.2298C>T	c.(2296-2298)gcC>gcT	p.A766A	AKAP1_ENST00000539273.1_Silent_p.A766A|AKAP1_ENST00000572557.1_Silent_p.A766A|AKAP1_ENST00000571629.1_Silent_p.A766A	NM_003488.3	NP_003479.1	Q92667	AKAP1_HUMAN	A kinase (PRKA) anchor protein 1	766	Tudor.				blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			endometrium(2)|liver(1)|lung(7)|ovary(2)|pancreas(1)|skin(1)	14	Breast(9;5.46e-08)					TCATCTGTGCCGCCCCTGGTG	0.647000													7	64					0	0	1	0	0
MBNL3	55796	broad.mit.edu	37	X	131573568	131573568	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chrX:131573568C>G	ENST00000370857.3	-	1	137	c.72G>C	c.(70-72)caG>caC	p.Q24H	MBNL3_ENST00000370844.1_5'UTR|MBNL3_ENST00000370839.3_Missense_Mutation_p.Q24H|MBNL3_ENST00000370853.3_Missense_Mutation_p.Q24H			Q9NUK0	MBNL3_HUMAN	muscleblind-like splicing regulator 3	24					mRNA processing|multicellular organismal development|regulation of RNA splicing|RNA splicing	Golgi apparatus|nucleus	nucleic acid binding|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(5)|prostate(2)	16	Acute lymphoblastic leukemia(192;0.000127)					AAGTTCCTCTCTGAAATTCTC	0.438000													13	142					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1956924	1956924	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr4:1956924A>G	ENST00000382895.3	+	15	2806	c.2375A>G	c.(2374-2376)tAt>tGt	p.Y792C	WHSC1_ENST00000508803.1_Missense_Mutation_p.Y792C|WHSC1_ENST00000482415.2_3'UTR|WHSC1_ENST00000382888.3_Missense_Mutation_p.Y140C|WHSC1_ENST00000382891.5_Missense_Mutation_p.Y792C|WHSC1_ENST00000382892.2_Missense_Mutation_p.Y792C	NM_133330.2	NP_579877.1	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	792					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		CCCGTTGCCTATCACAGCGGG	0.547000			T	IGH@	MM								7	45					0	0	1	0	0
LOC101927648	101927648	broad.mit.edu	37	1	143403554	143403554	+	RNA	SNP	T	T	G			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:143403554T>G	ENST00000423249.1	-	0	59																											GGAACAGGATTTCTTTGGCCA	0.468000													5	36					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26422429	26422429	+	Silent	SNP	G	G	C			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr22:26422429G>C	ENST00000335473.7	+	43	6739	c.6489G>C	c.(6487-6489)ggG>ggC	p.G2163G	MYO18B_ENST00000407587.2_Silent_p.G2164G|MYO18B_ENST00000536101.1_Silent_p.G2163G	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2163						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AAGAGGCTGGGGACACTGAGA	0.512000													45	193					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82538284	82538284	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr7:82538284C>G	ENST00000423517.2	-	8	13683	c.13346G>C	c.(13345-13347)aGg>aCg	p.R4449T	PCLO_ENST00000333891.8_Missense_Mutation_p.R4449T	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4380	PDZ.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						ACGAGACTCCCTGGGTTTATC	0.453000													11	61					0	0	1	0	0
PNMAL1	55228	broad.mit.edu	37	19	46973057	46973057	+	Silent	SNP	C	C	T	rs114979493	byFrequency	TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr19:46973057C>T	ENST00000313683.10	-	2	1541	c.1236G>A	c.(1234-1236)gaG>gaA	p.E412E	PNMAL1_ENST00000602246.1_Intron|PNMAL1_ENST00000438932.2_Intron	NM_001103149.1|NM_018215.3	NP_001096619.1|NP_060685.2	Q86V59	PNML1_HUMAN	paraneoplastic Ma antigen family-like 1	412										cervix(1)|endometrium(2)|large_intestine(8)|lung(8)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		AGGCTGTTGCCTCGGCAGGCT	0.602000													10	52					0	0	1	0	0
STX1B	112755	broad.mit.edu	37	16	31012888	31012888	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr16:31012888C>T	ENST00000215095.5	-	2	298	c.67G>A	c.(67-69)Gtg>Atg	p.V23M	STX1B_ENST00000565419.1_Missense_Mutation_p.V23M	NM_052874.3	NP_443106.1	P61266	STX1B_HUMAN	syntaxin 1B	23					intracellular protein transport|neurotransmitter transport|synaptic transmission	integral to plasma membrane	extracellular-glutamate-gated ion channel activity|SNAP receptor activity			breast(2)|endometrium(1)|large_intestine(5)|lung(5)	13						TCCCGATCCACGTGGACCACC	0.622000													8	70					0	0	1	0	0
RBM10	8241	broad.mit.edu	37	X	47045187	47045187	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chrX:47045187G>T	ENST00000377604.3	+	21	3170	c.2428G>T	c.(2428-2430)Gag>Tag	p.E810*	RBM10_ENST00000468791.1_Intron|RBM10_ENST00000329236.7_Nonsense_Mutation_p.E732*|RBM10_ENST00000345781.6_Nonsense_Mutation_p.E733*	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	810					mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						GAATGACATGGAGGTGAGGTG	0.537000													5	10					0.0215528	0.021762	1	1	0
CACNA1E	777	broad.mit.edu	37	1	181741329	181741329	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:181741329G>A	ENST00000526775.1	+	36	5209	c.5044G>A	c.(5044-5046)Gtg>Atg	p.V1682M	CACNA1E_ENST00000360108.3_Missense_Mutation_p.V1682M|CACNA1E_ENST00000367567.4_Missense_Mutation_p.V1308M|CACNA1E_ENST00000358338.5_Missense_Mutation_p.V1633M|CACNA1E_ENST00000367570.1_Missense_Mutation_p.V1701M|CACNA1E_ENST00000357570.5_Missense_Mutation_p.V1652M|CACNA1E_ENST00000367573.2_Missense_Mutation_p.V1701M	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1701					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity	p.V1701M(1)		NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						TCTGGCCTACGTGTACTTTGT	0.547000													17	127					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169340496	169340496	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr4:169340496C>T	ENST00000511577.1	-	19	2814	c.2567G>A	c.(2566-2568)cGc>cAc	p.R856H	DDX60L_ENST00000505890.1_Missense_Mutation_p.R856H|DDX60L_ENST00000260184.7_Missense_Mutation_p.R856H			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	856	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		CCATTTTTGGCGATGAGGAGC	0.363000													3	12					0	0	1	0	0
ATG16L1	55054	broad.mit.edu	37	2	234173588	234173588	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr2:234173588A>G	ENST00000392017.4	+	5	697	c.440A>G	c.(439-441)gAc>gGc	p.D147G	ATG16L1_ENST00000392018.1_Missense_Mutation_p.D147G|ATG16L1_ENST00000392020.4_Missense_Mutation_p.D147G|ATG16L1_ENST00000347464.5_Intron|ATG16L1_ENST00000373525.5_Intron	NM_001190266.1|NM_001190267.1|NM_030803.6	NP_001177195.1|NP_001177196.1|NP_110430.5	Q676U5	A16L1_HUMAN	autophagy related 16-like 1 (S. cerevisiae)	147					autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(7)|prostate(3)|skin(1)	25		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		GAGTGCCTAGACCTGCGCACT	0.502000													21	115					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50720743	50720743	+	Splice_Site	SNP	C	C	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr22:50720743C>A	ENST00000449103.1	-	19	3128		c.e19-1		PLXNB2_ENST00000359337.4_Splice_Site			O15031	PLXB2_HUMAN	plexin B2						regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCGGCCACCACTGCGGAGGGC	0.706000													13	62					9.31168e-06	9.98366e-06	1	1	0
KRT84	3890	broad.mit.edu	37	12	52775274	52775274	+	Silent	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr12:52775274C>T	ENST00000257951.3	-	5	1014	c.948G>A	c.(946-948)acG>acA	p.T316T	RP3-416H24.4_ENST00000547174.1_RNA	NM_033045.3	NP_149034.2	Q9NSB2	KRT84_HUMAN	keratin 84	316	Linker 12.|Rod.					keratin filament	structural constituent of epidermis			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(10)|skin(3)	27	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CAATGACCGACGTCTCTGAGA	0.547000													30	174					0	0	1	0	0
TBX18	9096	broad.mit.edu	37	6	85446667	85446667	+	Silent	SNP	A	A	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr6:85446667A>T	ENST00000369663.5	-	8	1897	c.1560T>A	c.(1558-1560)acT>acA	p.T520T	TBX18_ENST00000606784.1_Intron	NM_001080508.1	NP_001073977.1	O95935	TBX18_HUMAN	T-box 18	520					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|liver(1)|lung(31)|ovary(2)|pancreas(3)|prostate(6)|skin(3)	61		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		GTAATCTAAAAGTATTATAGG	0.478000													6	148					0	0	1	0	0
AC008103.5	0	broad.mit.edu	37	22	18842312	18842312	+	RNA	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr22:18842312G>A	ENST00000412938.1	+	0	2208																											TCCAGGAGATGGACTGGGACC	0.577000													4	18					0	0	1	0	0
SH3BP2	6452	broad.mit.edu	37	4	2831500	2831500	+	Silent	SNP	C	C	T	rs151102529		TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr4:2831500C>T	ENST00000356331.5	+	8	1128	c.867C>T	c.(865-867)ccC>ccT	p.P289P	SH3BP2_ENST00000503393.2_Silent_p.P346P|SH3BP2_ENST00000511747.1_Silent_p.P289P|SH3BP2_ENST00000452765.2_Silent_p.P289P|SH3BP2_ENST00000442312.2_Silent_p.P317P|SH3BP2_ENST00000435136.2_Silent_p.P289P	NM_003023.4	NP_003014.3	P78314	3BP2_HUMAN	SH3-domain binding protein 2	289					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	20				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		CCACCGCACCCGGCCTCCGGA	0.706000									Cherubism				7	67					0	0	1	0	0
PXN	5829	broad.mit.edu	37	12	120650261	120650261	+	Silent	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr12:120650261G>A	ENST00000397506.3	-	9	2121	c.1068C>T	c.(1066-1068)ggC>ggT	p.G356G	PXN_ENST00000538144.1_5'UTR|PXN-AS1_ENST00000535200.1_RNA|PXN_ENST00000228307.7_Silent_p.G544G|PXN_ENST00000424649.2_Silent_p.G510G|PXN-AS1_ENST00000542265.1_RNA|PXN_ENST00000267257.7_Silent_p.G558G|PXN_ENST00000536957.1_Silent_p.G542G|PXN_ENST00000458477.2_Silent_p.G377G			P49023	PAXI_HUMAN	paxillin	544	LIM zinc-binding 1.				cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGATGCAGCGGCCGGTGATGG	0.627000													11	50					0	0	1	0	0
PRKAA1	5562	broad.mit.edu	37	5	40771891	40771891	+	Silent	SNP	C	C	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr5:40771891C>A	ENST00000397128.2	-	4	446	c.438G>T	c.(436-438)gtG>gtT	p.V146V	PRKAA1_ENST00000354209.3_Silent_p.V161V|PRKAA1_ENST00000296800.4_Silent_p.V137V	NM_006251.5|NM_206907.3	NP_006242.5|NP_996790.3	Q13131	AAPK1_HUMAN	protein kinase, AMP-activated, alpha 1 catalytic subunit	146	Protein kinase.				activation of MAPK activity|cell cycle arrest|cholesterol biosynthetic process|fatty acid biosynthetic process|insulin receptor signaling pathway|negative regulation of glucosylceramide biosynthetic process|positive regulation of anti-apoptosis|positive regulation of cholesterol biosynthetic process|regulation of fatty acid oxidation|response to hypoxia	cytosol	ATP binding|cAMP-dependent protein kinase activity|metal ion binding|protein binding			breast(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Phenformin(DB00914)	CTCTATGGACCACCATATGCC	0.378000													16	137					3.52763e-06	3.8216e-06	1	1	0
NLN	57486	broad.mit.edu	37	5	65054569	65054569	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr5:65054569G>C	ENST00000380985.5	+	2	395	c.217G>C	c.(217-219)Gat>Cat	p.D73H	NLN_ENST00000502464.1_Intron	NM_020726.4	NP_065777.1	Q9BYT8	NEUL_HUMAN	neurolysin (metallopeptidase M3 family)	73					proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)		ACAGGTGTACGATGCTGTTGG	0.438000													6	108					0	0	1	0	0
TP53BP2	7159	broad.mit.edu	37	1	223994607	223994607	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:223994607C>G	ENST00000391878.2	-	6	796	c.28G>C	c.(28-30)Gaa>Caa	p.E10Q	TP53BP2_ENST00000343537.7_Missense_Mutation_p.E139Q	NM_005426.2	NP_005417.1	Q13625	ASPP2_HUMAN	tumor protein p53 binding protein, 2	133					apoptosis|cell cycle|induction of apoptosis|negative regulation of cell cycle|signal transduction	nucleus|perinuclear region of cytoplasm	NF-kappaB binding|protein binding|SH3 domain binding|SH3/SH2 adaptor activity			NS(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(2)	29				GBM - Glioblastoma multiforme(131;0.0958)		GATGCCATTTCCTGAAGTTCA	0.413000													33	98					0	0	1	0	0
IGHG1	3500	broad.mit.edu	37	14	106208462	106208462	+	RNA	SNP	C	C	G			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr14:106208462C>G	ENST00000390548.2	-	0	437																											TCACGTCCACCACCACGCATG	0.597000													31	124					0	0	1	0	0
CCDC116	164592	broad.mit.edu	37	22	21989500	21989500	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr22:21989500G>C	ENST00000292779.3	+	4	1309	c.1148G>C	c.(1147-1149)aGa>aCa	p.R383T		NM_152612.2	NP_689825.2	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	383										endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(5)	22	Colorectal(54;0.105)					CGCAAGGACAGAGGAGGCTCC	0.612000													6	34					0	0	1	0	0
AQR	9716	broad.mit.edu	37	15	35222464	35222464	+	Silent	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr15:35222464G>A	ENST00000156471.5	-	12	1234	c.1009C>T	c.(1009-1011)Cta>Tta	p.L337L		NM_014691.2	NP_055506.1	O60306	AQR_HUMAN	aquarius intron-binding spliceosomal factor	337						catalytic step 2 spliceosome	RNA binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(10)|lung(18)|ovary(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)	57		Lung NSC(122;8.7e-10)|all_lung(180;1.47e-08)		all cancers(64;4.34e-18)|GBM - Glioblastoma multiforme(113;4.59e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0283)		ATTACCTGTAGAGAAGTAATT	0.313000													10	101					0	0	1	0	0
EGFR	1956	broad.mit.edu	37	7	55259515	55259515	+	Missense_Mutation	SNP	T	T	G	rs121434568		TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr7:55259515T>G	ENST00000275493.2	+	21	2750	c.2573T>G	c.(2572-2574)cTg>cGg	p.L858R	EGFR_ENST00000454757.2_Missense_Mutation_p.L805R|EGFR_ENST00000455089.1_Missense_Mutation_p.L813R|EGFR_ENST00000442591.1_Intron	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	858	Protein kinase.		L -> M (found in a lung cancer sample).|L -> R (found in a lung cancer sample; somatic mutation; constitutively activated enzyme with strongly increased kinase activity).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L858R(1489)|p.L858Q(1)|p.L858K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	GATTTTGGGCTGGCCAAACTG	0.537000	L858R(NCIH1975_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			145	111					0	0	1	0	0
MAP2	4133	broad.mit.edu	37	2	210557457	210557457	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr2:210557457C>T	ENST00000360351.4	+	7	1069	c.563C>T	c.(562-564)cCt>cTt	p.P188L	MAP2_ENST00000447185.1_Missense_Mutation_p.P184L|MAP2_ENST00000361559.4_Intron|MAP2_ENST00000392194.1_Intron|MAP2_ENST00000199940.6_Intron	NM_002374.3	NP_002365.3	P11137	MAP2_HUMAN	microtubule-associated protein 2	188					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(36)|liver(2)|lung(42)|ovary(11)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	124		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	CAAAGTAAGCCTGGTGAAGAC	0.458000													7	72					0	0	1	0	0
MCL1	4170	broad.mit.edu	37	1	150549905	150549905	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:150549905C>A	ENST00000307940.3	-	2	750	c.751G>T	c.(751-753)Ggc>Tgc	p.G251C	MCL1_ENST00000464132.1_5'UTR|MCL1_ENST00000369026.2_Silent_p.L333L	NM_182763.2	NP_877495.1	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 (BCL2-related)	0					anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity			endometrium(2)|large_intestine(1)|lung(4)|prostate(1)	8	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CTGCAAAAGCCAGCAGCACAT	0.433000													31	231					4.74835e-14	5.42669e-14	1	1	0
SOX6	55553	broad.mit.edu	37	11	16068085	16068085	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr11:16068085C>A	ENST00000352083.6	-	12	1675	c.1598G>T	c.(1597-1599)gGg>gTg	p.G533V	SOX6_ENST00000316399.6_Missense_Mutation_p.G533V|SOX6_ENST00000527619.1_Missense_Mutation_p.G509V|SOX6_ENST00000528429.1_Missense_Mutation_p.G533V|SOX6_ENST00000528252.1_Missense_Mutation_p.G506V|SOX6_ENST00000396356.3_Missense_Mutation_p.G533V			P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6	533					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(23)|ovary(3)|pancreas(1)|prostate(2)	43						GCTGTTCAGCCCCATATTATT	0.507000													12	66					0.0135373	0.0138027	1	1	0
TTN	7273	broad.mit.edu	37	2	179589178	179589178	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr2:179589178G>A	ENST00000589042.1	-	72	21148	c.20924C>T	c.(20923-20925)cCg>cTg	p.P6975L	TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.P6658L|TTN_ENST00000342992.6_Missense_Mutation_p.P5731L|RP11-171I2.1_ENST00000590024.1_RNA|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6658	Ig-like 51.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAGAGTTCCGGAGTGCCAGC	0.468000													6	37					0	0	1	0	0
RAD52	5893	broad.mit.edu	37	12	1022618	1022618	+	Splice_Site	SNP	C	C	G			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr12:1022618C>G	ENST00000358495.3	-	12	1334	c.1195_splice	c.e12-1	p.G399_splice	RAD52_ENST00000535376.1_5'UTR|RAD52_ENST00000539046.1_Splice_Site_p.G322_splice|RAD52_ENST00000430095.2_Splice_Site_p.G399_splice	NM_134424.2	NP_602296.2	P43351	RAD52_HUMAN	RAD52 homolog (S. cerevisiae)	399					DNA recombinase assembly|mitotic recombination|reciprocal meiotic recombination	nucleoplasm	DNA binding|protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	19	all_cancers(10;0.0119)|all_epithelial(11;0.0171)|all_lung(10;0.0521)|Ovarian(42;0.0816)|Lung NSC(10;0.0987)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.0323)			TTCCCAGTTTCCTATGGAAGA	0.358000								Homologous recombination					40	271					0	0	1	0	0
CALML3	810	broad.mit.edu	37	10	5567196	5567196	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr10:5567196C>T	ENST00000315238.1	+	1	273	c.148C>T	c.(148-150)Cgg>Tgg	p.R50W	CALML3-AS1_ENST00000545372.1_RNA|RP11-116G8.5_ENST00000442008.2_RNA|CALML3-AS1_ENST00000542093.1_RNA	NM_005185.2	NP_005176.1	P27482	CALL3_HUMAN	calmodulin-like 3	50	EF-hand 2.						calcium ion binding			endometrium(3)|lung(2)	5						GGCCGAGCTGCGGGACATGAT	0.637000													4	33					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713774	142713774	+	RNA	SNP	A	A	G			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:142713774A>G	ENST00000369381.2	-	0	831																											CTTTTTCCACATTGTCATTTT	0.284000													6	74					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17690071	17690071	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:17690071G>A	ENST00000375448.4	+	16	1839	c.1813G>A	c.(1813-1815)Gtc>Atc	p.V605I		NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	605					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CTTCGGGCCCGTCATCAACGG	0.617000													4	35					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157370783	157370783	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr7:157370783G>A	ENST00000389413.3	-	17	2562	c.2459C>T	c.(2458-2460)gCg>gTg	p.A820V	PTPRN2_ENST00000404321.2_Missense_Mutation_p.A872V|PTPRN2_ENST00000409483.1_Missense_Mutation_p.A811V|PTPRN2_ENST00000389416.4_Missense_Mutation_p.A832V|PTPRN2_ENST00000389418.4_Missense_Mutation_p.A849V	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	849	Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GCCGTTCTCCGCGAGGGGTGT	0.622000													7	72					0	0	1	0	0
TRIM72	493829	broad.mit.edu	37	16	31230733	31230733	+	Missense_Mutation	SNP	G	G	A	rs149344436		TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr16:31230733G>A	ENST00000322122.3	+	4	894	c.610G>A	c.(610-612)Gcc>Acc	p.A204T		NM_001008274.3	NP_001008275.2	Q6ZMU5	TRI72_HUMAN	tripartite motif containing 72	204					exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(2)|lung(9)|skin(1)	15						GGCAGGGGTCGCCTTGCGCCG	0.672000													9	91					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48605322	48605322	+	Silent	SNP	A	A	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr3:48605322A>T	ENST00000328333.8	-	106	7985	c.7878T>A	c.(7876-7878)ggT>ggA	p.G2626G	COL7A1_ENST00000454817.1_Silent_p.G2594G	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	2626	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTCCCCGTTCACCCTGAGGGA	0.582000													21	35					0	0	1	0	0
VWF	7450	broad.mit.edu	37	12	6103065	6103065	+	Silent	SNP	G	G	A	rs151250563		TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr12:6103065G>A	ENST00000261405.5	-	37	6815	c.6561C>T	c.(6559-6561)aaC>aaT	p.N2187N		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	2187					blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	CGCAGACCCCGTTGGTCCGAC	0.557000													20	47					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124345674	124345674	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr10:124345674G>A	ENST00000368909.3	+	16	1664	c.1558G>A	c.(1558-1560)Gat>Aat	p.D520N	DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000338354.3_Missense_Mutation_p.D520N|DMBT1_ENST00000344338.3_Missense_Mutation_p.D510N|DMBT1_ENST00000368955.3_Missense_Mutation_p.D510N	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	520	SRCR 4.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CACCGTGTGTGATGACAGCTG	0.607000													52	458					0	0	1	0	0
DNAJA1	3301	broad.mit.edu	37	9	33026883	33026883	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr9:33026883G>T	ENST00000330899.4	+	3	388	c.205G>T	c.(205-207)Gaa>Taa	p.E69*	DNAJA1_ENST00000495015.1_Intron|DNAJA1_ENST00000544625.1_Intron	NM_001539.2	NP_001530.1	P31689	DNJA1_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 1	69					protein folding|response to heat|response to unfolded protein	membrane	ATP binding|heat shock protein binding|low-density lipoprotein particle receptor binding|metal ion binding|unfolded protein binding			large_intestine(2)|ovary(1)|skin(3)	6			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.102)		CAAAGGAGGAGAACAGGCAAT	0.423000													4	71					0.00024832	0.000260861	1	1	0
HSPG2	3339	broad.mit.edu	37	1	22176603	22176603	+	Silent	SNP	G	G	A	rs148384253	by1000genomes	TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:22176603G>A	ENST00000374695.3	-	57	7456	c.7377C>T	c.(7375-7377)ctC>ctT	p.L2459L	HSPG2_ENST00000430507.1_3'UTR	NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	2459	Ig-like C2-type 10.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GACCAGCAACGAGGCAGTTCA	0.672000													22	136					0	0	1	0	0
RASAL2	9462	broad.mit.edu	37	1	178411963	178411963	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:178411963G>A	ENST00000448150.3	+	8	1845	c.1027G>A	c.(1027-1029)Ggc>Agc	p.G343S	RASAL2_ENST00000462775.1_Missense_Mutation_p.G213S|RASAL2_ENST00000367649.3_Missense_Mutation_p.G361S	NM_170692.2	NP_733793.2	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2	213	Ras-GAP.				negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			biliary_tract(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(2)|lung(25)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54						TATTTTCTGGGGCGAACATTT	0.388000													6	112					0	0	1	0	0
AMIGO1	57463	broad.mit.edu	37	1	110051193	110051193	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:110051193G>T	ENST00000369864.4	-	2	691	c.342C>A	c.(340-342)taC>taA	p.Y114*	AMIGO1_ENST00000369862.1_Nonsense_Mutation_p.Y114*			Q86WK6	AMGO1_HUMAN	adhesion molecule with Ig-like domain 1	114					axonal fasciculation|heterophilic cell-cell adhesion|homophilic cell adhesion|myelination|positive regulation of axonogenesis	axon|integral to membrane				autonomic_ganglia(1)|breast(2)|endometrium(1)|large_intestine(6)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Colorectal(144;0.0129)|Lung(183;0.0182)|Epithelial(280;0.046)|all cancers(265;0.0492)|READ - Rectum adenocarcinoma(129;0.0689)|LUSC - Lung squamous cell carcinoma(189;0.227)		AGAGGTCCAGGTAGCGCAGGT	0.577000													12	55					0.000151284	0.000160547	1	1	0
LAMA1	284217	broad.mit.edu	37	18	6992567	6992567	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr18:6992567C>A	ENST00000389658.3	-	36	5254	c.5161G>T	c.(5161-5163)Gaa>Taa	p.E1721*		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	1721	Domain II and I.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TACTTGAGTTCAAGGGTGGCA	0.418000													17	74					3.41278e-10	3.81645e-10	1	1	0
OR2T12	127064	broad.mit.edu	37	1	248458808	248458808	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:248458808G>A	ENST00000317996.1	-	1	72	c.73C>T	c.(73-75)Ctc>Ttc	p.L25F		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	25					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			ATCATGAAGAGGACTTGGTGG	0.493000													10	144					0	0	1	0	0
ZNF587	84914	broad.mit.edu	37	19	58371288	58371288	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr19:58371288C>T	ENST00000339656.5	+	3	1690	c.1508C>T	c.(1507-1509)tCc>tTc	p.S503F	ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF587_ENST00000423137.1_Missense_Mutation_p.S502F|ZNF587_ENST00000419854.1_Missense_Mutation_p.S460F	NM_001204817.1|NM_032828.3	NP_001191746.1|NP_116217.1	Q96SQ5	ZN587_HUMAN	zinc finger protein 587	503					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|stomach(1)	15		Colorectal(82;0.000256)|all_neural(62;0.0577)|Breast(46;0.147)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)		TCATTTCTTTCCAGCTCTGCG	0.403000													17	115					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55148431	55148431	+	Silent	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:55148431C>T	ENST00000414150.2	+	14	2762	c.2484C>T	c.(2482-2484)gtC>gtT	p.V828V	MROH7_ENST00000409996.1_Silent_p.V396V|MROH7_ENST00000395690.2_Silent_p.V828V|MROH7_ENST00000339553.5_Silent_p.V828V|MROH7_ENST00000545244.1_Silent_p.V396V|MROH7_ENST00000454855.2_Silent_p.V346V|MROH7_ENST00000421030.2_Silent_p.V828V					maestro heat-like repeat family member 7																		AGAAGCCCGTCACCAAGGAGG	0.622000													7	78					0	0	1	0	0
CAMTA1	23261	broad.mit.edu	37	1	6880310	6880310	+	Splice_Site	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:6880310G>A	ENST00000303635.7	+	2	322	c.115_splice	c.e2+1	p.D39_splice	CAMTA1_ENST00000439411.2_Splice_Site_p.D39_splice|CAMTA1_ENST00000467404.2_Intron|CAMTA1_ENST00000557126.1_Splice_Site_p.D39_splice|CAMTA1_ENST00000476163.1_Intron|CAMTA1_ENST00000473578.1_Splice_Site_p.D39_splice	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	39					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		ACCTATAGAAGGTAGGATTTG	0.438000			T	WWTR1	epitheliod hemangioendothelioma								5	61					0	0	1	0	0
TACR3	6870	broad.mit.edu	37	4	104640635	104640635	+	Silent	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr4:104640635C>T	ENST00000304883.2	-	1	338	c.198G>A	c.(196-198)gcG>gcA	p.A66A		NM_001059.2	NP_001050.1	P29371	NK3R_HUMAN	tachykinin receptor 3	66						integral to plasma membrane	tachykinin receptor activity			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(19)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51		Hepatocellular(203;0.217)		UCEC - Uterine corpus endometrioid carcinoma (10;0.22)|OV - Ovarian serous cystadenocarcinoma(123;3.4e-08)		GCTGGGAGGGCGCGGGGGAAG	0.682000													7	52					0	0	1	0	0
ESRRB	2103	broad.mit.edu	37	14	76906056	76906056	+	Silent	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr14:76906056C>T	ENST00000380887.2	+	2	432	c.360C>T	c.(358-360)tgC>tgT	p.C120C	ESRRB_ENST00000509242.1_Silent_p.C120C|ESRRB_ENST00000507951.1_3'UTR|ESRRB_ENST00000556177.1_Silent_p.C120C|ESRRB_ENST00000261532.7_Silent_p.C120C			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	120						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		TGGCCTCCTGCGAGGCTTGCA	0.652000													10	29					0	0	1	0	0
GPN2	54707	broad.mit.edu	37	1	27216426	27216426	+	Silent	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:27216426G>A	ENST00000374135.4	-	1	362	c.162C>T	c.(160-162)taC>taT	p.Y54Y		NM_018066.3	NP_060536.3	Q9H9Y4	GPN2_HUMAN	GPN-loop GTPase 2	54							GTP binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|urinary_tract(1)	9						CGGCACACTCGTACGGCAGCC	0.706000													6	27					0	0	1	0	0
TAS2R30	259293	broad.mit.edu	37	12	11286342	11286342	+	Silent	SNP	A	A	G			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr12:11286342A>G	ENST00000539585.1	-	1	901	c.502T>C	c.(502-504)Ttg>Ctg	p.L168L	TAS2R14_ENST00000381852.4_Intron|PRR4_ENST00000536668.1_Intron	NM_001097643.1	NP_001091112.1			taste receptor, type 2, member 30											autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	13						GCACTCCTCAATTTGATCTTC	0.388000													11	156					0	0	1	0	0
DPPA4	55211	broad.mit.edu	37	3	109049515	109049515	+	Silent	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr3:109049515G>A	ENST00000335658.6	-	5	589	c.535C>T	c.(535-537)Ctg>Ttg	p.L179L	DPPA4_ENST00000478791.1_5'UTR	NM_018189.3	NP_060659.3	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	179						nucleus	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(17)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25						GAATTTTCCAGGGCAGGCGGC	0.527000													26	72					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23397975	23397975	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chrX:23397975G>A	ENST00000379361.4	+	2	1479	c.619G>A	c.(619-621)Gag>Aag	p.E207K		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	207					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						GAAATCTGCAGAGGCCATCCA	0.542000													8	116					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802218	185802218	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr2:185802218C>A	ENST00000302277.6	+	4	2689	c.2095C>A	c.(2095-2097)Ctt>Att	p.L699I		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	699						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GAACACAATACTTTTAAATGG	0.299000													18	88					1.99824e-07	2.21081e-07	1	1	0
GRIA2	2891	broad.mit.edu	37	4	158254022	158254022	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr4:158254022C>T	ENST00000296526.7	+	7	1259	c.934C>T	c.(934-936)Cgc>Tgc	p.R312C	GRIA2_ENST00000449365.1_Missense_Mutation_p.R265C|GRIA2_ENST00000264426.9_Missense_Mutation_p.R312C|GRIA2_ENST00000507898.1_Missense_Mutation_p.R265C|GRIA2_ENST00000393815.2_Missense_Mutation_p.R265C	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	312					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	TGAAGCCTTCCGCAACCTAAG	0.468000													24	108					0	0	1	0	0
CSPP1	79848	broad.mit.edu	37	8	68074105	68074105	+	Silent	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr8:68074105C>T	ENST00000262210.5	+	20	2614	c.2583C>T	c.(2581-2583)ctC>ctT	p.L861L	CSPP1_ENST00000412460.1_Silent_p.L516L|CSPP1_ENST00000521168.1_3'UTR	NM_024790.6	NP_079066.5	Q1MSJ5	CSPP1_HUMAN	centrosome and spindle pole associated protein 1	896						centrosome|microtubule|spindle				NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|prostate(3)|skin(1)|urinary_tract(1)	49	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			CAAGCAAACTCCAAAGACCTC	0.358000													7	160					0	0	1	0	0
MPP6	51678	broad.mit.edu	37	7	24718860	24718860	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr7:24718860G>A	ENST00000396475.2	+	11	1524	c.1225G>A	c.(1225-1227)Gaa>Aaa	p.E409K	MPP6_ENST00000222644.4_Missense_Mutation_p.E409K|MPP6_ENST00000409761.1_Missense_Mutation_p.E297K	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	409	Guanylate kinase-like.				protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						GGAACATGGGGAATATGAAGG	0.408000													22	69					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9067667	9067667	+	Silent	SNP	T	T	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr19:9067667T>A	ENST00000397910.4	-	3	19982	c.19779A>T	c.(19777-19779)gcA>gcT	p.A6593A		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6595	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CATTGGTTACTGCTATGTTTG	0.443000													31	136					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130419264	130419264	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chrX:130419264T>A	ENST00000370904.1	-	11	1439	c.529A>T	c.(529-531)Att>Ttt	p.I177F	IGSF1_ENST00000370903.3_Missense_Mutation_p.I186F|IGSF1_ENST00000370900.1_Missense_Mutation_p.I186F|IGSF1_ENST00000370910.1_Missense_Mutation_p.I177F|IGSF1_ENST00000361420.3_Missense_Mutation_p.I186F|IGSF1_ENST00000370901.4_Missense_Mutation_p.I186F			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	186	Ig-like C2-type 2.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						AGGTTGTCAATGGAGAATATG	0.522000													5	95					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58285002	58285002	+	Silent	SNP	G	G	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr15:58285002G>A	ENST00000249750.4	-	7	1466	c.699C>T	c.(697-699)ccC>ccT	p.P233P	ALDH1A2_ENST00000537372.1_Silent_p.P212P|ALDH1A2_ENST00000347587.3_Intron|ALDH1A2_ENST00000559517.1_Silent_p.P137P|ALDH1A2_ENST00000558231.1_Silent_p.P204P	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	233					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TGATGACCCCGGGAGGAAAGC	0.483000													32	69					0	0	1	0	0
ROCK2	9475	broad.mit.edu	37	2	11332817	11332817	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr2:11332817C>G	ENST00000315872.6	-	31	4157	c.3709G>C	c.(3709-3711)Gaa>Caa	p.E1237Q	ROCK2_ENST00000401753.1_Missense_Mutation_p.E994Q	NM_004850.3	NP_004841.2	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein kinase 2	1237	PH.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(6)|lung(10)|prostate(1)|skin(4)|stomach(3)|urinary_tract(2)	43	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		TTCTTACTTTCTCCTTCATTG	0.328000													8	32					0	0	1	0	0
HIST1H4K	8362	broad.mit.edu	37	6	27799293	27799293	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr6:27799293C>T	ENST00000357549.2	-	1	12	c.13G>A	c.(13-15)Ggc>Agc	p.G5S		NM_003541.2	NP_003532.1	P62805	H4_HUMAN	histone cluster 1, H4k	5					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			breast(1)|endometrium(1)|lung(3)|ovary(1)|prostate(1)	7						CCGCCTTTGCCGCGGCCAGAC	0.612000													15	58					0	0	1	0	0
ZNF668	79759	broad.mit.edu	37	16	31072956	31072956	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr16:31072956C>A	ENST00000417110.2	+	1	144	c.144C>A	c.(142-144)aaC>aaA	p.N48K	ZNF668_ENST00000535577.1_Silent_p.G431G|ZNF668_ENST00000300849.4_Silent_p.G431G|ZNF668_ENST00000539836.3_Silent_p.G454G|ZNF668_ENST00000426488.2_Silent_p.G454G|ZNF668_ENST00000538906.1_Silent_p.G431G|ZNF668_ENST00000394983.2_Silent_p.G431G			Q96K58	ZN668_HUMAN	zinc finger protein 668	128					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						GCAGCGCCAACCCCACCACCA	0.706000													35	177					2.42023e-17	2.79671e-17	1	1	0
ENO1	2023	broad.mit.edu	37	1	8928068	8928069	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:8928068_8928069delTC	ENST00000234590.4	-	5	407_408	c.288_289delGA	c.(286-291)gatgfs	p.EM96fs		NM_001428.3	NP_001419.1	P06733	ENOA_HUMAN	enolase 1, (alpha)	96					gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	10	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		GTTCCATCCATCTCGATCATCA	0.465													9	593	---	---	---	---					
SRSF4	6429	broad.mit.edu	37	1	29475681	29475698	+	In_Frame_Del	DEL	GCTCCGGCTCCGACTCTG	GCTCCGGCTCCGACTCTG	-			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr1:29475681_29475698delGCTCCGGCTCCGACTCTG	ENST00000373795.4	-	6	943_960	c.709_726delCAGAGTCGGAGCCGGAGC	c.(709-726)del	p.QSRSRS237del	SRSF4_ENST00000546138.1_In_Frame_Del_p.PESEPEQ135del|SRSF4_ENST00000466448.1_5'UTR	NM_005626.4	NP_005617.2	Q08170	SRSF4_HUMAN	serine/arginine-rich splicing factor 4	237	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(1)	27						TCTCTTTCTTgctccggctccgactctggctccggctc	0.573													13	179	---	---	---	---					
CCDC74A	90557	broad.mit.edu	37	2	132290639	132290644	+	Splice_Site	DEL	AATGGT	AATGGT	-			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr2:132290639_132290644delAATGGT	ENST00000295171.6	+	7	1142_1145	c.1007_splice	c.e7+1	p.335_splice	CCDC74A_ENST00000467992.2_3'UTR|CCDC74A_ENST00000409856.3_Splice_Site_p.269_splice	NM_001258304.1|NM_001258305.1|NM_138770.2	NP_001245233.1|NP_001245234.1|NP_620125.1	Q96AQ1	CC74A_HUMAN	coiled-coil domain containing 74A	335										endometrium(4)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19						CTCTCCAAGAAATGGTAAGTCCCACA	0.626													18	65	---	---	---	---					
AACSP1	729522	broad.mit.edu	37	5	178213910	178213910	+	RNA	DEL	G	G	-			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr5:178213910delG	ENST00000503486.2	-	0	647					NR_024035.1																						GGATGTGTCTGGGGCATCTGG	0.433													2	4	---	---	---	---					
MESP2	145873	broad.mit.edu	37	15	90320121	90320144	+	In_Frame_Del	DEL	AGGGGCAGGGGCAAGGGCAGGGGC	AGGGGCAGGGGCAAGGGCAGGGGC	-	rs56192595		TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr15:90320121_90320144delAGGGGCAGGGGCAAGGGCAGGGGC	ENST00000341735.3	+	1	533_556	c.533_556delAGGGGCAGGGGCAAGGGCAGGGGC	c.(532-558)gag>g	p.EGQGQGQGQ178del	MESP2_ENST00000560219.1_Intron|MESP2_ENST00000558723.1_Intron	NM_001039958.1	NP_001035047.1	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog (mouse)	178					Notch signaling pathway	nucleus	DNA binding	p.Q198_G205delQGQGQGQG(1)		kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			ACGCaggcggaggggcaggggcaagggcaggggcaggggcaggg	0.777													2	4	---	---	---	---					
RP11-863P13.2	0	broad.mit.edu	37	16	88226611	88226611	+	RNA	DEL	G	G	-			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr16:88226611delG	ENST00000568587.1	-	0	91																											tggtggtgatggtggtgatgg	0.522													2	4	---	---	---	---					
CPAMD8	27151	broad.mit.edu	37	19	17137452	17137452	+	Frame_Shift_Del	DEL	T	T	-			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr19:17137452delT	ENST00000443236.1	-	1	173	c.142delA	c.(142-144)tgfs	p.M48fs	CPAMD8_ENST00000388925.4_Start_Codon_Del	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						GCGCCGCTCATTTTTCGGCTC	0.791													2	4	---	---	---	---					
IZUMO2	126123	broad.mit.edu	37	19	50661592	50661592	+	Frame_Shift_Del	DEL	T	T	-			TCGA-MP-A4SW-01A-21D-A24P-08	TCGA-MP-A4SW-10A-01D-A24P-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	313b91b6-5cd0-4e1a-b9f1-2eeb0694d0f6	fca59518-94d9-4daf-8283-da6d6c85cd21	g.chr19:50661592delT	ENST00000293405.3	-	5	429	c.429delA	c.(427-429)gafs	p.E144fs		NM_152358.2	NP_689571.2	Q6UXV1	IZUM2_HUMAN	IZUMO family member 2	144						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	7						CCAACACCTCTTCTTTTAGCA	0.498													12	82	---	---	---	---					
