Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HIST1H2AG	8969	broad.mit.edu	37	6	27100920	27100920	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr6:27100920C>A	ENST00000359193.2	+	1	89	c.70C>A	c.(70-72)Ctc>Atc	p.L24I		NM_021064.4	NP_066408.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	24					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(1)|lung(4)|ovary(1)|urinary_tract(1)	17						TAGGGCCGGTCTCCAGTTCCC	0.657000													70	95					1.26778e-28	1.41991e-28	1	1	0
GK2	2712	broad.mit.edu	37	4	80328399	80328399	+	Missense_Mutation	SNP	T	T	G			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr4:80328399T>G	ENST00000358842.3	-	1	973	c.956A>C	c.(955-957)gAa>gCa	p.E319A		NM_033214.2	NP_149991.2	Q14410	GLPK2_HUMAN	glycerol kinase 2	319					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			autonomic_ganglia(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	39						AACAGAACCTTCCAGTGCATA	0.418000													20	95					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197407783	197407783	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr1:197407783C>G	ENST00000367397.1	+	6	2857	c.1999C>G	c.(1999-2001)Cgg>Ggg	p.R667G	RP11-75C23.1_ENST00000422250.1_RNA|CRB1_ENST00000535699.1_Missense_Mutation_p.R1262G|CRB1_ENST00000367400.3_Missense_Mutation_p.R1286G|CRB1_ENST00000538660.1_Missense_Mutation_p.R750G|CRB1_ENST00000367399.2_Missense_Mutation_p.R1174G|CRB1_ENST00000544212.1_Missense_Mutation_p.R767G			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1286	Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						ATGTATGTGCCGGCCAGGTTT	0.428000													22	45					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90438841	90438841	+	Missense_Mutation	SNP	T	T	G			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr6:90438841T>G	ENST00000369393.3	-	36	5273	c.5158A>C	c.(5158-5160)Aat>Cat	p.N1720H	MDN1_ENST00000428876.1_Missense_Mutation_p.N1720H			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1720					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GCAATATTATTCCTGTGTAGG	0.423000													15	10					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27676911	27676911	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr2:27676911G>A	ENST00000260570.3	-	33	3752	c.3649C>T	c.(3649-3651)Cag>Tag	p.Q1217*		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	1217					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					TCTGCTTTCTGAAAGTCCTTC	0.637000													43	164					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1263123	1263123	+	Silent	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr11:1263123G>A	ENST00000447027.1	+	31	5080	c.5022G>A	c.(5020-5022)acG>acA	p.T1674T	MUC5B_ENST00000529681.1_Silent_p.T1671T			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	1671	7 X Cys-rich subdomain repeats.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CAGCCACCACGGGAGGCCCCA	0.662000													12	20					0	0	1	0	0
RABEP2	79874	broad.mit.edu	37	16	28925559	28925559	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr16:28925559C>G	ENST00000358201.4	-	5	1480	c.892G>C	c.(892-894)Gag>Cag	p.E298Q	RABEP2_ENST00000544477.1_Missense_Mutation_p.E227Q|RABEP2_ENST00000357573.6_Missense_Mutation_p.E298Q	NM_024816.2	NP_079092.2	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	298					endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	16						ACACTCACCTCTGTCTGCAGC	0.642000													11	54					0	0	1	0	0
TCF25	22980	broad.mit.edu	37	16	89977541	89977541	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr16:89977541G>A	ENST00000263347.7	+	16	1618	c.1339G>A	c.(1339-1341)Gaa>Aaa	p.E447K	TCF25_ENST00000263346.8_Silent_p.L642L|RP11-566K11.7_ENST00000570217.1_RNA			Q9BQ70	TCF25_HUMAN	transcription factor 25 (basic helix-loop-helix)	27					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|ovary(3)|skin(1)|urinary_tract(2)	18		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		ACCAGGGCCTGAACAGGCTGA	0.662000													50	111					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169101400	169101400	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr5:169101400C>A	ENST00000256935.8	+	6	501	c.421C>A	c.(421-423)Ctg>Atg	p.L141M		NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	141					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CAAGGATGAGCTGAAGGAACT	0.493000													6	58					0.00198382	0.00201989	1	1	0
PDE4A	5141	broad.mit.edu	37	19	10568764	10568764	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr19:10568764G>C	ENST00000380702.2	+	9	1021	c.1021G>C	c.(1021-1023)Gag>Cag	p.E341Q	PDE4A_ENST00000293683.5_Missense_Mutation_p.E337Q|PDE4A_ENST00000344979.3_Missense_Mutation_p.E124Q|PDE4A_ENST00000440014.2_Missense_Mutation_p.E302Q|PDE4A_ENST00000592685.1_Missense_Mutation_p.E341Q|PDE4A_ENST00000352831.6_Missense_Mutation_p.E363Q			P27815	PDE4A_HUMAN	phosphodiesterase 4A, cAMP-specific	363	Catalytic.				signal transduction	cytosol|membrane fraction|perinuclear region of cytoplasm|ruffle membrane|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(20;5.8e-10)|Epithelial(33;7.58e-07)|all cancers(31;3.91e-06)		Cilostazol(DB01166)|Dipyridamole(DB00975)|Dyphylline(DB00651)|Enprofylline(DB00824)|Iloprost(DB01088)|Milrinone(DB00235)|Pentoxifylline(DB00806)|Phentolamine(DB00692)|Tadalafil(DB00820)|Theophylline(DB00277)	CGATCAAGAAGAGCTCCTGGC	0.547000													10	78					0	0	1	0	0
CEP95	90799	broad.mit.edu	37	17	62522248	62522248	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr17:62522248A>T	ENST00000556440.2	+	10	1592	c.1082A>T	c.(1081-1083)aAg>aTg	p.K361M	CEP95_ENST00000553412.1_Missense_Mutation_p.K197M|CEP95_ENST00000577476.1_3'UTR	NM_138363.1	NP_612372.1	Q96GE4	CEP95_HUMAN	centrosomal protein 95kDa	361						centrosome|spindle pole	protein binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|ovary(1)	13						AGGCCAAGAAAGAGATTAACA	0.383000													4	49					0	0	1	0	0
CSRP2BP	57325	broad.mit.edu	37	20	18143376	18143376	+	Silent	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr20:18143376G>A	ENST00000278816.2	+	7	2108	c.1458G>A	c.(1456-1458)ccG>ccA	p.P486P	CSRP2BP_ENST00000489634.2_Silent_p.P358P|CSRP2BP_ENST00000377681.2_Silent_p.P485P|CSRP2BP_ENST00000435364.2_Silent_p.P486P			Q9H8E8	CSR2B_HUMAN	CSRP2 binding protein	486					histone H3 acetylation	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm	LIM domain binding|N-acetyltransferase activity			NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|stomach(1)	34						CCATGACTCCGGAAGCTCGGA	0.498000													11	103					0	0	1	0	0
EBI3	10148	broad.mit.edu	37	19	4234671	4234671	+	Silent	SNP	C	C	T	rs146774568		TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr19:4234671C>T	ENST00000221847.5	+	4	440	c.387C>T	c.(385-387)ccC>ccT	p.P129P		NM_005755.2	NP_005746.2	Q14213	IL27B_HUMAN	Epstein-Barr virus induced 3	129	Fibronectin type-III 2.				humoral immune response|positive regulation of alpha-beta T cell proliferation|positive regulation of interferon-gamma biosynthetic process|T-helper 1 type immune response	extracellular space|plasma membrane	cytokine activity|cytokine receptor activity			large_intestine(1)|lung(2)|ovary(1)|urinary_tract(1)	5		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0336)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGTCAAGCCCGACCCTCCAG	0.547000													51	187					0	0	1	0	0
CTNND2	1501	broad.mit.edu	37	5	11236849	11236849	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr5:11236849G>C	ENST00000304623.8	-	10	1904	c.1715C>G	c.(1714-1716)gCc>gGc	p.A572G	CTNND2_ENST00000359640.2_Missense_Mutation_p.A572G|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000458100.2_Missense_Mutation_p.A139G|CTNND2_ENST00000511377.1_Missense_Mutation_p.A481G|CTNND2_ENST00000503622.1_Missense_Mutation_p.A235G	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	572					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TTGCAAGTAGGCTGCCGCGTT	0.468000													20	146					0	0	1	0	0
PTCD1	26024	broad.mit.edu	37	7	99022877	99022877	+	Silent	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr7:99022877G>A	ENST00000292478.4	-	6	1528	c.1278C>T	c.(1276-1278)ctC>ctT	p.L426L	ATP5J2-PTCD1_ENST00000413834.1_Silent_p.L475L|PTCD1_ENST00000555673.1_Silent_p.L475L	NM_015545.3	NP_056360.2			pentatricopeptide repeat domain 1											endometrium(5)|large_intestine(3)|lung(16)|ovary(2)|skin(1)	27	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			CCACTGCGGTGAGGGCTGCTG	0.652000													90	221					0	0	1	0	0
OLFML2B	25903	broad.mit.edu	37	1	161953644	161953644	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr1:161953644G>A	ENST00000294794.3	-	8	2497	c.2074C>T	c.(2074-2076)Cgg>Tgg	p.R692W	OLFML2B_ENST00000367938.1_Missense_Mutation_p.R175W|OLFML2B_ENST00000367940.2_Missense_Mutation_p.R693W	NM_015441.1	NP_056256.1	Q68BL8	OLM2B_HUMAN	olfactomedin-like 2B	692	Olfactomedin-like.									breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(22)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	48	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.0172)			TTGGCATTCCGCTGGTTGTAG	0.542000													49	318					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16823301	16823301	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr11:16823301G>A	ENST00000355661.3	-	16	2231	c.2221C>T	c.(2221-2223)Cag>Tag	p.Q741*	PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000531066.1_Nonsense_Mutation_p.Q741*|PLEKHA7_ENST00000448080.2_Nonsense_Mutation_p.Q741*			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	741					epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						TCCAAGTGCTGGGGCTGGTCT	0.557000													14	73					0	0	1	0	0
DCUN1D4	23142	broad.mit.edu	37	4	52779738	52779738	+	Silent	SNP	A	A	G			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr4:52779738A>G	ENST00000334635.5	+	11	1047	c.867A>G	c.(865-867)aaA>aaG	p.K289K	DCUN1D4_ENST00000381441.3_Silent_p.K254K|DCUN1D4_ENST00000381437.4_Silent_p.K229K|DCUN1D4_ENST00000451288.2_Silent_p.K333K	NM_001040402.1	NP_001035492.1	Q92564	DCNL4_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 4	289										endometrium(2)|large_intestine(2)|lung(2)|ovary(2)|skin(1)	9			GBM - Glioblastoma multiforme(4;1.93e-11)|LUSC - Lung squamous cell carcinoma(32;0.00654)			ATAAAGACAAACAGATGTCCT	0.373000													7	38					0	0	1	0	0
CTC-260E6.6	0	broad.mit.edu	37	19	20369963	20369963	+	RNA	SNP	T	T	G			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr19:20369963T>G	ENST00000593655.1	-	0	199																											CTGGAGGGTCTACTATGTATC	0.393000													4	39					0	0	1	0	0
UNC13B	10497	broad.mit.edu	37	9	35403451	35403451	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr9:35403451G>A	ENST00000378495.3	+	38	4567	c.4345G>A	c.(4345-4347)Gac>Aac	p.D1449N	UNC13B_ENST00000396787.1_Missense_Mutation_p.D1480N|UNC13B_ENST00000378496.4_Missense_Mutation_p.D1468N	NM_006377.3	NP_006368.3	O14795	UN13B_HUMAN	unc-13 homolog B (C. elegans)	1449	C2 3.				excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(16)|liver(2)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GGCTGCCAATGACCTCAAGTG	0.547000													20	57					0	0	1	0	0
COL9A3	1299	broad.mit.edu	37	20	61461720	61461720	+	Silent	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr20:61461720C>T	ENST00000343916.3	+	23	1173	c.1170C>T	c.(1168-1170)ctC>ctT	p.L390L		NM_001853.3	NP_001844.3	Q14050	CO9A3_HUMAN	collagen, type IX, alpha 3	390	Triple-helical region 3 (COL3).				axon guidance	collagen type IX				breast(1)|endometrium(3)|large_intestine(1)|lung(18)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	28	Breast(26;5.68e-08)					AGGGGGCCCTCGGCCCACAAG	0.697000													4	10					0	0	1	0	0
GCM2	9247	broad.mit.edu	37	6	10881939	10881939	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr6:10881939G>C	ENST00000379491.4	-	1	235	c.88C>G	c.(88-90)Cag>Gag	p.Q30E	SYCP2L_ENST00000543878.1_Intron|RP11-637O19.3_ENST00000480294.1_Intron	NM_004752.3	NP_004743.1	O75603	GCM2_HUMAN	glial cells missing homolog 2 (Drosophila)	30					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	30	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				TCACTTACCTGAGGCATCTGC	0.637000													18	58					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51524441	51524441	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr6:51524441G>A	ENST00000371117.3	-	61	10758	c.10483C>T	c.(10483-10485)Ctc>Ttc	p.L3495F		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3495					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					ACAGCCAAGAGAAGCTTGGAG	0.448000													11	51					0	0	1	0	0
CHPF2	54480	broad.mit.edu	37	7	150935688	150935688	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr7:150935688T>C	ENST00000035307.2	+	4	3753	c.2240T>C	c.(2239-2241)cTc>cCc	p.L747P	CHPF2_ENST00000495645.1_Missense_Mutation_p.L739P	NM_019015.1	NP_061888.1	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	747						Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(4)|prostate(1)|skin(3)	17						CGCTGCCGCCTCAGCAACCTG	0.642000													6	37					0	0	1	0	0
OR13D1	286365	broad.mit.edu	37	9	107457305	107457305	+	Nonsense_Mutation	SNP	T	T	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr9:107457305T>A	ENST00000318763.5	+	1	646	c.603T>A	c.(601-603)tgT>tgA	p.C201*		NM_001004484.1	NP_001004484.1	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D, member 1	201					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(10)|ovary(1)|prostate(2)|skin(2)	19						TGCCTTTCTGTGGGAATAATG	0.413000													14	90					0	0	1	0	0
C19orf55	148137	broad.mit.edu	37	19	36259105	36259105	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr19:36259105G>C	ENST00000544099.1	+	10	1332	c.1269G>C	c.(1267-1269)aaG>aaC	p.K423N	C19orf55_ENST00000396908.4_Missense_Mutation_p.R422T			Q2NL68	CS055_HUMAN	chromosome 19 open reading frame 55	0										cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)	15	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CAGGTGCTAAGAGCCCATAGG	0.632000													8	26					0	0	1	0	0
DUSP4	1846	broad.mit.edu	37	8	29194805	29194805	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr8:29194805T>C	ENST00000240100.2	-	4	1312	c.923A>G	c.(922-924)gAg>gGg	p.E308G	DUSP4_ENST00000240101.2_Missense_Mutation_p.E217G	NM_001394.6	NP_001385.1	Q13115	DUS4_HUMAN	dual specificity phosphatase 4	308	Tyrosine-protein phosphatase.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			endometrium(1)|large_intestine(1)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)		CTTAACGAACTCGAAGGCCTC	0.637000													22	107					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100210349	100210349	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr2:100210349C>T	ENST00000317233.4	-	14	2009	c.1774G>A	c.(1774-1776)Gag>Aag	p.E592K	AFF3_ENST00000409579.1_Missense_Mutation_p.E617K|AFF3_ENST00000356421.2_Missense_Mutation_p.E617K|AFF3_ENST00000409236.1_Missense_Mutation_p.E592K	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	592					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						GAGGTCCTCTCGGTGCGCCTG	0.796000													5	18					0	0	1	0	0
IL17RC	84818	broad.mit.edu	37	3	9974846	9974846	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr3:9974846G>T	ENST00000295981.3	+	19	2163	c.1945G>T	c.(1945-1947)Gtc>Ttc	p.V649F	IL17RC_ENST00000413608.1_Missense_Mutation_p.V565F|IL17RC_ENST00000416074.2_Missense_Mutation_p.V404F|IL17RC_ENST00000403601.3_Missense_Mutation_p.V578F|IL17RC_ENST00000498214.1_3'UTR|IL17RC_ENST00000455057.1_Missense_Mutation_p.V546F|IL17RC_ENST00000383812.4_Missense_Mutation_p.V563F	NM_153461.3	NP_703191.1	Q8NAC3	I17RC_HUMAN	interleukin 17 receptor C	649	SEFIR.					integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						CGGCGTGGTGGTCTTGCTCTT	0.726000											OREG0015383	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	9					2.54575e-18	2.79533e-18	1	1	0
DNAH5	1767	broad.mit.edu	37	5	13920675	13920675	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr5:13920675T>C	ENST00000265104.4	-	6	816	c.712A>G	c.(712-714)Acg>Gcg	p.T238A		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	238	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					AAGTAGTCCGTAGGTTCCTTT	0.348000									Kartagener syndrome				32	51					0	0	1	0	0
FHOD1	29109	broad.mit.edu	37	16	67271205	67271205	+	Silent	SNP	G	G	C			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr16:67271205G>C	ENST00000258201.4	-	9	1177	c.930C>G	c.(928-930)gtC>gtG	p.V310V	FHOD1_ENST00000567687.1_Intron	NM_013241.2	NP_037373.2	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	310	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	34		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		GGTGGCGCTGGACCAGCGCTT	0.657000													24	153					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	62995045	62995045	+	Silent	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr1:62995045C>T	ENST00000251157.5	-	30	3717	c.3684G>A	c.(3682-3684)cgG>cgA	p.R1228R	DOCK7_ENST00000340370.5_Silent_p.R1197R	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1228					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding	p.R1197R(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						GGTCAGAGTACCGCGGGTCTG	0.403000													14	61					0	0	1	0	0
EPHA6	285220	broad.mit.edu	37	3	96963154	96963154	+	Silent	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr3:96963154C>T	ENST00000470610.2	+	5	1672	c.1629C>T	c.(1627-1629)ctC>ctT	p.L543L	EPHA6_ENST00000389672.5_Intron			Q9UF33	EPHA6_HUMAN	EPH receptor A6	0						integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(2)|lung(60)|ovary(3)|skin(11)|stomach(5)|upper_aerodigestive_tract(2)	101						GCTGTTCTCTCAAAACAGACC	0.403000													7	41					0	0	1	0	0
CHPF2	54480	broad.mit.edu	37	7	150935689	150935689	+	Silent	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr7:150935689C>T	ENST00000035307.2	+	4	3754	c.2241C>T	c.(2239-2241)ctC>ctT	p.L747L	CHPF2_ENST00000495645.1_Silent_p.L739L	NM_019015.1	NP_061888.1	Q9P2E5	CHPF2_HUMAN	chondroitin polymerizing factor 2	747						Golgi cisterna membrane|integral to membrane	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(4)|prostate(1)|skin(3)	17						GCTGCCGCCTCAGCAACCTGG	0.642000													6	38					0	0	1	0	0
SLC5A1	6523	broad.mit.edu	37	22	32498150	32498150	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr22:32498150A>G	ENST00000266088.4	+	13	1841	c.1591A>G	c.(1591-1593)Att>Gtt	p.I531V	SLC5A1_ENST00000543737.1_Missense_Mutation_p.I404V	NM_000343.3	NP_000334.1	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 1	531					carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	37						GTACTTTGCCATTATCCTCTT	0.488000													5	71					0	0	1	0	0
ANKRD6	22881	broad.mit.edu	37	6	90333173	90333173	+	Silent	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr6:90333173G>A	ENST00000369408.5	+	10	1186	c.837G>A	c.(835-837)gtG>gtA	p.V279V	ANKRD6_ENST00000447838.2_Silent_p.V314V|ANKRD6_ENST00000522441.1_Silent_p.V314V|LYRM2_ENST00000520441.1_Intron|ANKRD6_ENST00000339746.4_Silent_p.V314V|ANKRD6_ENST00000520793.1_Silent_p.V255V	NM_001242813.1	NP_001229742.1	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	314							protein binding			NS(1)|endometrium(3)|large_intestine(7)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|stomach(2)	21		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		AACAGGCTGTGGCCAGAAAAG	0.537000													5	7					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42047825	42047825	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr1:42047825C>T	ENST00000372584.1	-	3	3658	c.2644G>A	c.(2644-2646)Gag>Aag	p.E882K	HIVEP3_ENST00000429157.2_Missense_Mutation_p.E882K|HIVEP3_ENST00000372583.1_Missense_Mutation_p.E882K|HIVEP3_ENST00000247584.5_Missense_Mutation_p.E882K	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	882	Acidic 2.|No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TGGAACTCCTCAGTCTTCTCA	0.607000													21	249					0	0	1	0	0
ODF3L1	161753	broad.mit.edu	37	15	76016572	76016572	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr15:76016572T>C	ENST00000332145.2	+	1	255	c.32T>C	c.(31-33)gTg>gCg	p.V11A		NM_175881.3	NP_787077.1	Q8IXM7	OD3L1_HUMAN	outer dense fiber of sperm tails 3-like 1	11										kidney(1)|lung(1)	2						AGGAGCTCTGTGTACTTTGCA	0.572000													11	68					0	0	1	0	0
GMIP	51291	broad.mit.edu	37	19	19748831	19748831	+	Silent	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr19:19748831G>A	ENST00000203556.4	-	10	962	c.825C>T	c.(823-825)gtC>gtT	p.V275V	GMIP_ENST00000587238.1_Silent_p.V275V|GMIP_ENST00000445806.2_Silent_p.V275V	NM_016573.2	NP_057657.2	Q9P107	GMIP_HUMAN	GEM interacting protein	275					negative regulation of Rho GTPase activity|small GTPase mediated signal transduction	cytosol	metal ion binding|protein binding|Rho GTPase activator activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						TGGCCTCGCGGACACAGGCCT	0.701000													13	13					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54142271	54142271	+	Silent	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr8:54142271G>A	ENST00000265572.3	-	4	1026	c.729C>T	c.(727-729)atC>atT	p.I243I	OPRK1_ENST00000520287.1_Silent_p.I243I|RP11-162D9.3_ENST00000524425.1_RNA|OPRK1_ENST00000524278.1_Silent_p.I154I	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	243					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	TGTAGCAGACGATGATGATGA	0.542000													12	76					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113075148	113075148	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr11:113075148G>A	ENST00000316851.7	+	2	238	c.238G>A	c.(238-240)Gac>Aac	p.D80N	NCAM1_ENST00000533760.1_5'UTR|NCAM1_ENST00000401611.2_Missense_Mutation_p.D89N|NCAM1_ENST00000397957.4_3'UTR	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	90	Ig-like C2-type 1.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		CAACATCGACGACGCCGGCAT	0.527000													8	56					0	0	1	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179306709	179306709	+	Silent	SNP	C	C	A	rs142837577		TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr5:179306709C>A	ENST00000356834.3	-	8	1372	c.1335G>T	c.(1333-1335)gcG>gcT	p.A445A	TBC1D9B_ENST00000355235.3_Silent_p.A445A	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	445						integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCGCCTCCTGCGCACAGAAGC	0.642000													34	85					3.90053e-15	4.24135e-15	1	1	0
CDHR3	222256	broad.mit.edu	37	7	105645063	105645063	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr7:105645063C>A	ENST00000542731.1	+	8	1090	c.982C>A	c.(982-984)Cgc>Agc	p.R328S	CDHR3_ENST00000541203.1_3'UTR|CDHR3_ENST00000478080.1_Missense_Mutation_p.R240S|CDHR3_ENST00000470188.1_3'UTR|CDHR3_ENST00000343407.5_Missense_Mutation_p.R45S|CDHR3_ENST00000317716.9_Missense_Mutation_p.R328S			Q6ZTQ4	CDHR3_HUMAN	cadherin-related family member 3	328	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|cervix(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)	23						TCAGGAGAATCGCATCCAGAT	0.483000													20	32					3.51602e-12	3.78648e-12	1	1	0
TCF25	22980	broad.mit.edu	37	16	89977623	89977623	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr16:89977623G>T	ENST00000263346.8	+	18	2064	c.2008G>T	c.(2008-2010)Gag>Tag	p.E670*	TCF25_ENST00000263347.7_Nonstop_Mutation_p.*474L|RP11-566K11.7_ENST00000570217.1_RNA	NM_014972.2	NP_055787.1	Q9BQ70	TCF25_HUMAN	transcription factor 25 (basic helix-loop-helix)	670					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|ovary(3)|skin(1)|urinary_tract(2)	18		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		GGACGACGCTGAGGGGGAGGG	0.622000													53	125					9.53978e-28	1.05788e-27	1	1	0
CELSR3	1951	broad.mit.edu	37	3	48697251	48697251	+	Silent	SNP	T	T	C			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr3:48697251T>C	ENST00000544264.1	-	1	3097	c.2817A>G	c.(2815-2817)ccA>ccG	p.P939P	CELSR3_ENST00000164024.4_Silent_p.P939P			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	939	Cadherin 6.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CTGCCTTCTGTGGGATGCCAT	0.512000													26	68					0	0	1	0	0
RNF213	57674	broad.mit.edu	37	17	78320203	78320203	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr17:78320203G>A	ENST00000582970.1	+	29	8211	c.8068G>A	c.(8068-8070)Ggg>Agg	p.G2690R	RNF213_ENST00000336301.6_Missense_Mutation_p.G763R|RNF213_ENST00000508628.2_Missense_Mutation_p.G2739R	NM_001256071.1	NP_001243000.1	Q9HCF4	ALO17_HUMAN	ring finger protein 213	0										NS(1)|breast(7)|central_nervous_system(1)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(23)|lung(36)|ovary(11)|pancreas(2)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	130	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GCTGGCCATCGGGGTGTGTTA	0.517000													8	91					0	0	1	0	0
KCNK3	3777	broad.mit.edu	37	2	26950617	26950617	+	Silent	SNP	C	C	T	rs61736657		TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr2:26950617C>T	ENST00000302909.3	+	2	491	c.366C>T	c.(364-366)ctC>ctT	p.L122L		NM_002246.2	NP_002237.1	O14649	KCNK3_HUMAN	potassium channel, subfamily K, member 3	122					synaptic transmission	integral to plasma membrane				endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|urinary_tract(1)	14	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGCTCACGCTCGTCATGTTCC	0.657000													46	158					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9072666	9072666	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr19:9072666A>G	ENST00000397910.4	-	3	14983	c.14780T>C	c.(14779-14781)gTa>gCa	p.V4927A		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4929	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTCCTGGATACCTCGGTAGT	0.527000													6	135					0	0	1	0	0
NIN	51199	broad.mit.edu	37	14	51224990	51224990	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr14:51224990C>T	ENST00000245441.5	-	18	2948	c.2758G>A	c.(2758-2760)Gaa>Aaa	p.E920K	NIN_ENST00000453196.1_Missense_Mutation_p.E920K|NIN_ENST00000382041.3_Missense_Mutation_p.E920K|NIN_ENST00000382043.4_Intron|NIN_ENST00000389868.3_Intron|NIN_ENST00000324330.9_Missense_Mutation_p.E920K|NIN_ENST00000530997.2_Missense_Mutation_p.E920K	NM_020921.3	NP_065972.3	Q8N4C6	NIN_HUMAN	ninein (GSK3B interacting protein)	920					centrosome localization	centrosome|microtubule	calcium ion binding|GTP binding|protein binding			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(13)|lung(16)|ovary(1)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	71	all_epithelial(31;0.00244)|Breast(41;0.127)					CTTAGGTCTTCCAGGTCTTGG	0.488000			T	PDGFRB	MPD								91	113					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152286961	152286961	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr1:152286961C>G	ENST00000368799.1	-	3	436	c.401G>C	c.(400-402)aGa>aCa	p.R134T	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	134					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			ATTCCCTTTTCTATTGTTTCT	0.363000									Ichthyosis				6	50					0	0	1	0	0
SESN2	83667	broad.mit.edu	37	1	28600590	28600590	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr1:28600590G>A	ENST00000253063.3	+	7	1262	c.941G>A	c.(940-942)tGc>tAc	p.C314Y		NM_031459.4	NP_113647.1	P58004	SESN2_HUMAN	sestrin 2	314					cell cycle arrest	cytoplasm|nucleus				cervix(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(2)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	27		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		GACATGCTGTGCTTTGTGGAA	0.587000													54	135					0	0	1	0	0
CECR2	27443	broad.mit.edu	37	22	18018336	18018336	+	Silent	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr22:18018336C>T	ENST00000262608.8	+	11	1221	c.1221C>T	c.(1219-1221)gaC>gaT	p.D407D	CECR2_ENST00000400585.2_Silent_p.D265D|CECR2_ENST00000342247.5_Silent_p.D378D|CECR2_ENST00000400573.4_Silent_p.D406D	NM_031413.3	NP_113601.2	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	448					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	59		all_epithelial(15;0.139)		Lung(27;0.146)		CAGTTCTAGACGTGGTAAAGG	0.403000													23	22					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	186062653	186062653	+	Nonsense_Mutation	SNP	G	G	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr1:186062653G>T	ENST00000271588.4	+	66	10277	c.10048G>T	c.(10048-10050)Gag>Tag	p.E3350*	HMCN1_ENST00000367492.2_Nonsense_Mutation_p.E3350*	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3350	Ig-like C2-type 32.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						AGATGAAGCAGAGAAACTAAT	0.388000													16	93					0.000308642	0.000320073	1	1	0
CRISP2	7180	broad.mit.edu	37	6	49663607	49663607	+	Silent	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr6:49663607C>T	ENST00000339139.4	-	9	782	c.546G>A	c.(544-546)ccG>ccA	p.P182P		NM_001142407.2|NM_001142408.2|NM_001142417.2|NM_001142435.2|NM_001261822.1|NM_003296.3	NP_001135879.1|NP_001135880.1|NP_001135889.1|NP_001135907.1|NP_001248751.1|NP_003287.1	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2	182						extracellular space				kidney(1)|large_intestine(2)|lung(10)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			CTTGTTGGTACGGGGTATTCT	0.348000													3	34					0	0	1	0	0
KIF13A	63971	broad.mit.edu	37	6	17809015	17809015	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr6:17809015A>C	ENST00000378814.5	-	18	2146	c.2147T>G	c.(2146-2148)cTc>cGc	p.L716R	KIF13A_ENST00000259711.6_Missense_Mutation_p.L716R|KIF13A_ENST00000378826.2_Missense_Mutation_p.L716R|KIF13A_ENST00000378816.5_Missense_Mutation_p.L716R|KIF13A_ENST00000378843.2_Missense_Mutation_p.L716R	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	716					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			ATTGGCACTGAGGTTTGCAGC	0.423000													11	21					0	0	1	0	0
OR2A14	135941	broad.mit.edu	37	7	143826975	143826975	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr7:143826975C>T	ENST00000408899.2	+	1	825	c.770C>T	c.(769-771)aCg>aTg	p.T257M		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					GCCATTGTCACGTACATGGCC	0.547000													28	278					0	0	1	0	0
MYLK	4638	broad.mit.edu	37	3	123411657	123411657	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr3:123411657C>T	ENST00000360772.3	-	20	3868	c.3490G>A	c.(3490-3492)Gac>Aac	p.D1164N	MYLK_ENST00000346322.5_Missense_Mutation_p.D1095N|MYLK_ENST00000510775.1_5'UTR|MYLK_ENST00000360304.3_Missense_Mutation_p.D1164N|MYLK_ENST00000475616.1_Missense_Mutation_p.D1164N|MYLK_ENST00000359169.1_Missense_Mutation_p.D1164N			Q15746	MYLK_HUMAN	myosin light chain kinase	1164	Actin-binding (calcium/calmodulin- insensitive) (By similarity).|Ig-like C2-type 7.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		AAGCCTCTGTCCTCAGGCAGT	0.592000													48	24					0	0	1	0	0
CD180	4064	broad.mit.edu	37	5	66479084	66479084	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr5:66479084G>T	ENST00000256447.4	-	3	1744	c.1587C>A	c.(1585-1587)caC>caA	p.H529Q		NM_005582.2	NP_005573.2	Q99467	CD180_HUMAN	CD180 molecule	529					inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(2)|kidney(7)|large_intestine(12)|liver(1)|lung(8)|ovary(1)|stomach(2)	34		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		TCAGGCTGTTGTGGCTTAAGT	0.478000													20	11					1.2644e-06	1.33597e-06	1	1	0
SIRT3	23410	broad.mit.edu	37	11	230517	230517	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr11:230517G>T	ENST00000382743.4	-	4	844	c.742C>A	c.(742-744)Cat>Aat	p.H248N	SIRT3_ENST00000532956.1_Missense_Mutation_p.H248N|SIRT3_ENST00000529382.1_Missense_Mutation_p.H106N|SIRT3_ENST00000528702.1_5'UTR|SIRT3_ENST00000524564.1_Missense_Mutation_p.H184N|SIRT3_ENST00000525319.1_Missense_Mutation_p.H167N	NM_001017524.2|NM_012239.5	NP_001017524.1|NP_036371.1	Q9NTG7	SIRT3_HUMAN	sirtuin 3	248	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			endometrium(1)|lung(5)|urinary_tract(1)	7		all_cancers(49;1.58e-09)|all_epithelial(84;2.71e-06)|Breast(177;0.000162)|Ovarian(85;0.000626)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;3.66e-27)|Epithelial(43;2.02e-26)|OV - Ovarian serous cystadenocarcinoma(40;2.9e-21)|BRCA - Breast invasive adenocarcinoma(625;3.88e-05)|Lung(200;0.111)|LUSC - Lung squamous cell carcinoma(625;0.129)		AAGGTTCCATGAGCTTCAACC	0.557000													12	64					0.00244969	0.00247176	1	1	0
MUC16	94025	broad.mit.edu	37	19	9077501	9077501	+	Silent	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr19:9077501G>A	ENST00000397910.4	-	3	10148	c.9945C>T	c.(9943-9945)tcC>tcT	p.S3315S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3316	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGACTCTAGGGAGACAGAGG	0.532000													27	87					0	0	1	0	0
MAP4	4134	broad.mit.edu	37	3	47950808	47950808	+	Silent	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr3:47950808G>A	ENST00000426837.2	-	10	5241	c.5154C>T	c.(5152-5154)gtC>gtT	p.V1718V	MAP4_ENST00000264724.11_Silent_p.V308V|MAP4_ENST00000395734.3_Intron|MAP4_ENST00000383737.4_Intron|MAP4_ENST00000360240.6_Intron			P27816	MAP4_HUMAN	microtubule-associated protein 4	582					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		GAGGAGCTTCGACTTTGCTAT	0.423000													7	53					0	0	1	0	0
ZNF395	55893	broad.mit.edu	37	8	28206270	28206270	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr8:28206270C>T	ENST00000344423.5	-	10	1639	c.1508G>A	c.(1507-1509)cGg>cAg	p.R503Q	ZNF395_ENST00000523202.1_Missense_Mutation_p.R503Q|ZNF395_ENST00000523095.1_Missense_Mutation_p.R503Q	NM_018660.2	NP_061130.1	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	503					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		CTTCTTCCACCGGCAGGCCGT	0.607000													15	64					0	0	1	0	0
TNFRSF10D	8793	broad.mit.edu	37	8	23006028	23006028	+	Missense_Mutation	SNP	G	G	C	rs140280307		TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr8:23006028G>C	ENST00000312584.3	-	3	387	c.293C>G	c.(292-294)cCg>cGg	p.P98R		NM_003840.4	NP_003831.2	Q9UBN6	TR10D_HUMAN	tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain	98					anti-apoptosis|apoptosis	integral to membrane	TRAIL binding|transmembrane receptor activity			endometrium(1)|large_intestine(2)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9		Prostate(55;0.0421)|Breast(100;0.067)		Colorectal(74;0.0147)|COAD - Colon adenocarcinoma(73;0.0612)		CTCTGTGCACGGGTTACAGGC	0.458000													7	77					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1096455	1096455	+	Silent	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr11:1096455C>T	ENST00000441003.2	+	34	6507	c.6480C>T	c.(6478-6480)atC>atT	p.I2160I	MUC2_ENST00000361558.6_Silent_p.I298I	NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	4522						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	GAGTTTACATCGACAACTACC	0.572000													6	117					0	0	1	0	0
ADRA1A	148	broad.mit.edu	37	8	26722336	26722336	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr8:26722336C>T	ENST00000380573.3	-	2	1174	c.151G>A	c.(151-153)Gta>Ata	p.V51I	ADRA1A_ENST00000380587.1_Missense_Mutation_p.V51I|ADRA1A_ENST00000380582.3_Missense_Mutation_p.V51I|ADRA1A_ENST00000354550.4_Missense_Mutation_p.V51I|ADRA1A_ENST00000519229.1_Missense_Mutation_p.V51I|ADRA1A_ENST00000276393.4_Missense_Mutation_p.V51I|ADRA1A_ENST00000380586.1_Missense_Mutation_p.V51I|ADRA1A_ENST00000358857.5_Missense_Mutation_p.V51I|ADRA1A_ENST00000380572.3_Missense_Mutation_p.V51I|ADRA1A_ENST00000380581.2_Missense_Mutation_p.V51I			P35348	ADA1A_HUMAN	adrenoceptor alpha 1A	51					activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|skin(1)	36		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	TGACAGGCTACGGAGAGGATC	0.607000													24	405					0	0	1	0	0
MAGIX	79917	broad.mit.edu	37	X	49021098	49021098	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chrX:49021098C>G	ENST00000412696.2	+	3	250	c.250C>G	c.(250-252)Cat>Gat	p.H84D	MAGIX_ENST00000498742.1_3'UTR|MAGIX_ENST00000425661.2_Missense_Mutation_p.H84D|MAGIX_ENST00000376339.1_5'UTR|MAGIX_ENST00000376338.3_5'UTR	NM_024859.2	NP_079135.2	Q9H6Y5	MAGIX_HUMAN	MAGI family member, X-linked	84																	TCGCCTGCCTCATGCCACTAT	0.557000													14	213					0	0	1	0	0
TRIM42	287015	broad.mit.edu	37	3	140397395	140397395	+	Silent	SNP	C	C	G			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr3:140397395C>G	ENST00000286349.3	+	1	515	c.324C>G	c.(322-324)ctC>ctG	p.L108L		NM_152616.4	NP_689829.3	Q8IWZ5	TRI42_HUMAN	tripartite motif containing 42	108						intracellular	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(11)|lung(33)|ovary(2)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	69						AGGGCCGCCTCAGGAGCATCC	0.552000													9	21					0	0	1	0	0
FOXF1	2294	broad.mit.edu	37	16	86544852	86544852	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr16:86544852G>T	ENST00000262426.4	+	1	720	c.677G>T	c.(676-678)gGc>gTc	p.G226V		NM_001451.2	NP_001442.2	Q12946	FOXF1_HUMAN	forkhead box F1	226					branching involved in open tracheal system development|cardiac left ventricle morphogenesis|embryonic ectodermal digestive tract morphogenesis|endocardial cushion development|in utero embryonic development|lung vasculature development|midgut development|pancreas development|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|ureter development|venous blood vessel development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(1)	12						TCGTACATgggcggctgcggc	0.746000													5	7					0.000602214	0.000618789	1	1	0
DNM1P47	100216544	broad.mit.edu	37	15	102292785	102292785	+	RNA	SNP	C	C	G	rs61084368		TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr15:102292785C>G	ENST00000561463.1	+	0	831																		p.Q125E(1)									TGCTGCTTCTCAGAGCTGCTG	0.602000													4	40					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167517677	167517677	+	Silent	SNP	C	C	T	rs147074209	by1000genomes	TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr5:167517677C>T	ENST00000519204.1	+	7	1369	c.1251C>T	c.(1249-1251)gcC>gcT	p.A417A	TENM2_ENST00000545108.1_Silent_p.A538A|TENM2_ENST00000520394.1_Silent_p.A306A|TENM2_ENST00000403607.2_Silent_p.A371A|CTB-178M22.1_ENST00000517408.1_RNA|TENM2_ENST00000518659.1_Silent_p.A538A					teneurin transmembrane protein 2																		AGAATGAAGCCGTGTTTGTGC	0.498000													6	119					0	0	1	0	0
AGO4	192670	broad.mit.edu	37	1	36316528	36316528	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr1:36316528T>C	ENST00000373210.3	+	17	2596	c.2351T>C	c.(2350-2352)cTg>cCg	p.L784P	AGO4_ENST00000488778.1_3'UTR	NM_017629.3	NP_060099.2			argonaute RISC catalytic component 4																		CTCCAGCTACTGACTTACCAG	0.493000													18	95					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105410281	105410281	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr14:105410281T>C	ENST00000333244.5	-	7	11626	c.11507A>G	c.(11506-11508)gAt>gGt	p.D3836G	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3836						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GAGACTCACATCGGCCTCCAC	0.592000													225	274					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17743615	17743615	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr19:17743615T>C	ENST00000428389.2	-	29	3667	c.3668A>G	c.(3667-3669)aAg>aGg	p.K1223R	UNC13A_ENST00000519716.2_Missense_Mutation_p.K1135R|UNC13A_ENST00000551649.1_Missense_Mutation_p.K1135R|UNC13A_ENST00000552293.1_Missense_Mutation_p.K1135R|UNC13A_ENST00000252773.7_Missense_Mutation_p.K1135R|UNC13A_ENST00000550896.1_Missense_Mutation_p.K1133R			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	1135	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						CACGCGGTCCTTGAAGGCGGG	0.542000													9	90					0	0	1	0	0
RP11-146E13.4	0	broad.mit.edu	37	14	19857028	19857028	+	RNA	SNP	G	G	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr14:19857028G>T	ENST00000548109.1	+	0	72																											TCAGCATCCTGGATAATAAAG	0.383000													6	81					0.0293803	0.0293803	1	1	0
RAB11FIP1	80223	broad.mit.edu	37	8	37732478	37732478	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr8:37732478T>C	ENST00000330843.4	-	3	1189	c.1177A>G	c.(1177-1179)Atg>Gtg	p.M393V	RAB11FIP1_ENST00000287263.4_Missense_Mutation_p.M393V|RAB11FIP1_ENST00000522727.1_Missense_Mutation_p.M245V|RAB11FIP1_ENST00000524118.1_Missense_Mutation_p.M245V	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	393					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			GGCAGGGTCATAGACTTCAAG	0.587000													15	132					0	0	1	0	0
KIAA0430	9665	broad.mit.edu	37	16	15695990	15695990	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr16:15695990C>T	ENST00000396368.3	-	23	4690	c.4484G>A	c.(4483-4485)cGg>cAg	p.R1495Q	KIAA0430_ENST00000551742.1_Missense_Mutation_p.R1495Q|KIAA0430_ENST00000548025.1_Missense_Mutation_p.R1492Q|KIAA0430_ENST00000540441.2_Missense_Mutation_p.R1330Q|KIAA0430_ENST00000344181.3_Missense_Mutation_p.R1178Q|KIAA0430_ENST00000547936.1_5'UTR|KIAA0430_ENST00000602337.1_Missense_Mutation_p.R1492Q	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	1494						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						AAGTAAAGACCGCACATTCTT	0.398000													34	200					0	0	1	0	0
SPINK1	6690	broad.mit.edu	37	5	147209174	147209174	+	Silent	SNP	G	G	A	rs35006579	byFrequency	TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr5:147209174G>A	ENST00000510027.2	-	2	132	c.75C>T	c.(73-75)tcC>tcT	p.S25S	SPINK1_ENST00000296695.5_Silent_p.S25S			P00995	ISK1_HUMAN	serine peptidase inhibitor, Kazal type 1	25						extracellular region	protein binding|serine-type endopeptidase inhibitor activity			endometrium(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCTTCCCAGGGAGTCAGCTC	0.378000									Hereditary Pancreatitis				4	12					0	0	1	0	0
TFAP2C	7022	broad.mit.edu	37	20	55208625	55208625	+	Splice_Site	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr20:55208625G>A	ENST00000201031.2	+	4	1046	c.803_splice	c.e4+1	p.R268_splice	TFAP2C_ENST00000544508.1_Splice_Site_p.R99_splice	NM_003222.3	NP_003213.1	Q92754	AP2C_HUMAN	transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)	268					cell-cell signaling|male gonad development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	13			Colorectal(105;0.229)			GTTCTCAGAAGGTACTTGGGG	0.458000													11	28					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23522936	23522936	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr5:23522936C>T	ENST00000296682.3	+	8	1006	c.824C>T	c.(823-825)cCt>cTt	p.P275L		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	275	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CACTTTGGCCCTTATGAGGGC	0.557000										HNSCC(3;0.000094)			34	75					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71592714	71592714	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr2:71592714G>A	ENST00000409544.1	+	6	2503	c.1873G>A	c.(1873-1875)Gct>Act	p.A625T	ZNF638_ENST00000410075.1_3'UTR|ZNF638_ENST00000355812.3_Missense_Mutation_p.A625T|ZNF638_ENST00000377802.2_Missense_Mutation_p.A625T|ZNF638_ENST00000264447.4_Missense_Mutation_p.A625T	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	625					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						ACCTACAAGCGCTACAAAGAG	0.373000													3	36					0	0	1	0	0
FHOD1	29109	broad.mit.edu	37	16	67271384	67271384	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr16:67271384G>C	ENST00000258201.4	-	8	1090	c.843C>G	c.(841-843)atC>atG	p.I281M	FHOD1_ENST00000567687.1_Intron	NM_013241.2	NP_037373.2	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	281	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	34		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		ACACCTTGTTGATGAGGGTGA	0.602000													21	109					0	0	1	0	0
ARFIP2	23647	broad.mit.edu	37	11	6498959	6498959	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr11:6498959C>T	ENST00000254584.2	-	7	942	c.859G>A	c.(859-861)Gaa>Aaa	p.E287K	ARFIP2_ENST00000423813.2_Missense_Mutation_p.E249K|ARFIP2_ENST00000396777.3_Missense_Mutation_p.E287K|ARFIP2_ENST00000445086.2_Missense_Mutation_p.E202K	NM_012402.3	NP_036534.1	P53365	ARFP2_HUMAN	ADP-ribosylation factor interacting protein 2	287	AH.				actin cytoskeleton organization|cellular component movement|lamellipodium assembly|ruffle organization|small GTPase mediated signal transduction	cell cortex|plasma membrane|ruffle	GTP binding|GTP-dependent protein binding|Rac GTPase binding			endometrium(2)|large_intestine(4)|liver(1)|lung(4)|pancreas(1)|prostate(1)|skin(2)	15		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;3.41e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TTGTTTTCTTCCAGGAACTTG	0.547000													8	74					0	0	1	0	0
BCL2L10	10017	broad.mit.edu	37	15	52404691	52404691	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr15:52404691A>G	ENST00000260442.3	-	1	281	c.233T>C	c.(232-234)gTg>gCg	p.V78A	BCL2L10_ENST00000561198.1_Missense_Mutation_p.V78A	NM_020396.2	NP_065129.1	Q9HD36	B2L10_HUMAN	BCL2-like 10 (apoptosis facilitator)	68					activation of caspase activity|anti-apoptosis|female gamete generation|spermatogenesis	cytosol|integral to membrane|membrane fraction|mitochondrion|nuclear membrane	protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)	2				all cancers(107;0.0148)		CATCAGCGCCACCAGCTCGAA	0.692000													14	12					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238283328	238283328	+	Silent	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr2:238283328G>A	ENST00000295550.4	-	8	3858	c.3406C>T	c.(3406-3408)Ctg>Ttg	p.L1136L	COL6A3_ENST00000353578.4_Silent_p.L930L|COL6A3_ENST00000392003.2_Silent_p.L729L|COL6A3_ENST00000347401.3_Silent_p.L935L|COL6A3_ENST00000346358.4_Silent_p.L936L|COL6A3_ENST00000392004.3_Silent_p.L930L|COL6A3_ENST00000472056.1_Silent_p.L529L|COL6A3_ENST00000409809.1_Silent_p.L930L	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1136	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGGACGATCAGCAGCTGGGGC	0.637000													17	92					0	0	1	0	0
ATG4C	84938	broad.mit.edu	37	1	63307117	63307117	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr1:63307117C>T	ENST00000317868.4	+	10	1315	c.1108C>T	c.(1108-1110)Ccc>Tcc	p.P370S	ATG4C_ENST00000371120.3_Missense_Mutation_p.P370S	NM_032852.3	NP_116241.2	Q96DT6	ATG4C_HUMAN	autophagy related 4C, cysteine peptidase	370					autophagic vacuole assembly|protein targeting to membrane|proteolysis	cytosol|extracellular region	cysteine-type endopeptidase activity		ATG4C/FBXO38(2)	NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(3)|ovary(1)|prostate(2)	19						CTGCCCTTCTCCCAAAAAGAT	0.308000													5	16					0	0	1	0	0
IFT172	26160	broad.mit.edu	37	2	27693878	27693878	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr2:27693878C>T	ENST00000260570.3	-	16	1712	c.1609G>A	c.(1609-1611)Gtg>Atg	p.V537M		NM_015662.1	NP_056477.1	Q9UG01	IF172_HUMAN	intraflagellar transport 172 homolog (Chlamydomonas)	537					cilium assembly	cilium	binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(17)|lung(17)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	43	Acute lymphoblastic leukemia(172;0.155)					GCTACCAGCACGTCACTTCCT	0.453000													33	37					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175335092	175335092	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr1:175335092G>A	ENST00000367674.1	-	11	2944	c.2236C>T	c.(2236-2238)Cct>Tct	p.P746S	TNR_ENST00000263525.2_Missense_Mutation_p.P746S	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	746	Fibronectin type-III 5.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TCTGCCCCAGGCTCTAGATCT	0.522000													26	146					0	0	1	0	0
TSFM	10102	broad.mit.edu	37	12	58176936	58176936	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr12:58176936T>A	ENST00000454289.3	+	2	314	c.101T>A	c.(100-102)tTt>tAt	p.F34Y	RP11-571M6.15_ENST00000553083.1_3'UTR|TSFM_ENST00000350762.5_5'UTR|TSFM_ENST00000323833.8_Missense_Mutation_p.F34Y|RP11-571M6.15_ENST00000471530.1_Missense_Mutation_p.F49I|TSFM_ENST00000548851.1_Missense_Mutation_p.F34Y|TSFM_ENST00000543727.1_Missense_Mutation_p.F34Y|TSFM_ENST00000497617.1_3'UTR|TSFM_ENST00000540550.1_Missense_Mutation_p.F34Y|TSFM_ENST00000550559.1_Missense_Mutation_p.F34Y	NM_005726.5	NP_005717.3	P43897	EFTS_HUMAN	Ts translation elongation factor, mitochondrial	34				HTF -> ARV (in Ref. 3; AAC37577).	regulation of transcription elongation, DNA-dependent	mitochondrion|nucleus	translation elongation factor activity			endometrium(1)|kidney(1)|large_intestine(5)|prostate(1)	8	all_cancers(7;6.31e-80)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					AGGCACACATTTTATGCTGGG	0.547000											OREG0021954	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	142					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157396739	157396739	+	Silent	SNP	C	C	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr7:157396739C>T	ENST00000389413.3	-	15	2389	c.2286G>A	c.(2284-2286)gcG>gcA	p.A762A	PTPRN2_ENST00000404321.2_Silent_p.A814A|PTPRN2_ENST00000389418.4_Silent_p.A791A|PTPRN2_ENST00000409483.1_Silent_p.A753A|PTPRN2_ENST00000389416.4_Silent_p.A774A	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	791	Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		GGCTGTTCTCCGCCTTCAGCA	0.632000													15	124					0	0	1	0	0
TEX10	54881	broad.mit.edu	37	9	103109070	103109070	+	Missense_Mutation	SNP	T	T	C	rs140613442	byFrequency	TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr9:103109070T>C	ENST00000374902.4	-	3	975	c.799A>G	c.(799-801)Atc>Gtc	p.I267V	TEX10_ENST00000535814.1_Missense_Mutation_p.I270V|TEX10_ENST00000537512.1_Missense_Mutation_p.I202V	NM_017746.3	NP_060216.2	Q9NXF1	TEX10_HUMAN	testis expressed 10	267						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			NS(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	38		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TTCCAGTTGATAAAAATGGAG	0.458000													4	50					0	0	1	0	0
NDOR1	27158	broad.mit.edu	37	9	140108780	140108780	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr9:140108780A>G	ENST00000371521.4	+	6	720	c.637A>G	c.(637-639)Atg>Gtg	p.M213V	NDOR1_ENST00000427047.2_Missense_Mutation_p.M179V|NDOR1_ENST00000344894.5_Missense_Mutation_p.M213V|NDOR1_ENST00000458322.2_Missense_Mutation_p.M213V	NM_001144026.1	NP_001137498.1	Q9UHB4	NDOR1_HUMAN	NADPH dependent diflavin oxidoreductase 1	213	FAD-binding FR-type.				cell death	cytosol|intermediate filament cytoskeleton|nucleus|perinuclear region of cytoplasm	flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding|oxidoreductase activity|protein binding			breast(1)|endometrium(5)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.37e-05)|Epithelial(140;0.00057)		CCTAGCACCCATGATCTCCAA	0.632000													32	114					0	0	1	0	0
SP7	121340	broad.mit.edu	37	12	53722857	53722857	+	Silent	SNP	G	G	T			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr12:53722857G>T	ENST00000536324.2	-	3	652	c.369C>A	c.(367-369)ccC>ccA	p.P123P	SP7_ENST00000537210.2_Silent_p.P105P|SP7_ENST00000303846.3_Silent_p.P123P	NM_001173467.1	NP_001166938.1	Q8TDD2	SP7_HUMAN	Sp7 transcription factor	123					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			cervix(2)|large_intestine(3)|lung(7)|skin(1)|urinary_tract(1)	14						TGTAGACACTGGGCAGACAGT	0.582000													14	83					9.31168e-06	9.7468e-06	1	1	0
H3F3AP4	440926	broad.mit.edu	37	2	175585079	175585079	+	RNA	DEL	A	A	-			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr2:175585079delA	ENST00000442996.1	+	0	217																											TTTCATTCTCAAAAAAAAAAA	0.368											OREG0015078	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	6	---	---	---	---					
FGFBP1	9982	broad.mit.edu	37	4	15938178	15938178	+	Frame_Shift_Del	DEL	T	T	-	rs144178676		TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr4:15938178delT	ENST00000382333.1	-	3	372	c.78delA	c.(76-78)aafs	p.K26fs	FGFBP1_ENST00000259988.2_Frame_Shift_Del_p.K26fs	NM_005130.4	NP_005121.1	Q14512	FGFP1_HUMAN	fibroblast growth factor binding protein 1	26					cell-cell signaling|negative regulation of cell proliferation|signal transduction	extracellular space|plasma membrane	heparin binding			NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(2)|prostate(2)|skin(1)	10						CATTCTTCACTTTTTTTTTCC	0.527													7	144	---	---	---	---					
EGFR	1956	broad.mit.edu	37	7	55242466	55242474	+	In_Frame_Del	DEL	GAATTAAGA	GAATTAAGA	-	rs121913438		TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr7:55242466_55242474delGAATTAAGA	ENST00000275493.2	+	19	2413_2421	c.2236_2244delGAATTAAGA	c.(2236-2244)del	p.ELR746del	EGFR_ENST00000454757.2_In_Frame_Del_p.ELR693del|EGFR_ENST00000455089.1_In_Frame_Del_p.ELR701del|EGFR_ENST00000442591.1_Intron	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	746	Protein kinase.		Missing (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.E746_A750del(1007)|p.L747_P753>S(123)|p.L747_A750>P(82)|p.L747_T751del(76)|p.E746_S752>V(57)|p.L747_S752del(34)|p.L747_T751>P(21)|p.E746_T751>A(21)|p.L747_E749del(16)|p.E746_E749del(9)|p.L747_T751>S(7)|p.L747_P753>Q(7)|p.K745_E749del(6)|p.E746_T751>V(6)|p.L747S(6)|p.E746_S752>A(6)|p.E746_T751>VA(6)|p.L747_T751>Q(5)|p.E746_T751del(4)|p.E746_T751>I(4)|p.E746_S752>D(4)|p.E746_S752>I(4)|p.K745_E746insVPVAIK(4)|p.E746_A750>IP(3)|p.L747P(3)|p.L747_S752>Q(3)|p.E746K(3)|p.E746_T751>IP(3)|p.E746_T751>VP(3)|p.E746_A750>RP(2)|p.L747_S752>QH(2)|p.E746_S752del(2)|p.E746_P753>VS(2)|p.E746_A750>QP(2)|p.L747_K754del(2)|p.L747_K754>ST(1)|p.E746_A750>VP(1)|p.L747_P753del(1)|p.E746del(1)|p.L747_K754>N(1)|p.E746_P753>IS(1)|p.E746_T751>L(1)|p.L747_R748>FP(1)|p.L747_T751>A(1)|p.I744_E749>LKR(1)|p.E746_P753>LS(1)|p.E746_T751>Q(1)|p.E746_T751>S(1)|p.E746_P753>VQ(1)|p.E746_A750>DP(1)|p.E746V(1)|p.I744_A750>VK(1)|p.R748I(1)|p.K745_A750del(1)|p.R748K(1)		NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CGCTATCAAGGAATTAAGAGAAGCAACAT	0.478	E746K(HCC827_LUNG)|E746_A750del(NCIH1650_LUNG)|E746_A750del(PC14_LUNG)|L747_P753>Q(HCC4006_LUNG)	8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			23	97	---	---	---	---					
CPXM2	119587	broad.mit.edu	37	10	125528165	125528167	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr10:125528165_125528167delCAG	ENST00000241305.3	-	9	1328_1330	c.1174_1176delCTG	c.(1174-1176)del	p.L392del	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	392	Poly-Leu.				cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		CGAACTGCACCAGCAGCAGCAGC	0.626													7	232	---	---	---	---					
SPON1	10418	broad.mit.edu	37	11	14101782	14101782	+	RNA	DEL	T	T	-	rs145316549		TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr11:14101782delT	ENST00000310358.7	+	0	1211							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		Attttttttcttttttttttt	0.443													2	4	---	---	---	---					
ASCL1	429	broad.mit.edu	37	12	103352171	103352172	+	In_Frame_Ins	INS	-	-	GCA	rs71438488		TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr12:103352171_103352172insGCA	ENST00000266744.3	+	1	708_709	c.149_150insGCA	c.(148-150)gca>gGCAca	p.50_50A>GT		NM_004316.3	NP_004307.2	P50553	ASCL1_HUMAN	achaete-scute family bHLH transcription factor 1	50					cerebral cortex GABAergic interneuron differentiation|negative regulation of apoptosis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|noradrenergic neuron fate commitment|Notch signaling pathway|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|response to retinoic acid|sympathetic nervous system development	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity			NS(3)|large_intestine(1)|lung(1)	5						gcgcagagcgcgcagcagcagc	0.757													4	2	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	5313074	5313076	+	RNA	DEL	GGT	GGT	-			TCGA-MP-A4T6-01A-32D-A25L-08	TCGA-MP-A4T6-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	6AE764C2-9E16-4137-936D-9CB0BF040CE7	AFF7CA52-44A5-4C2F-81FF-CDAD428EC346	g.chr16:5313074_5313076delGGT	ENST00000569895.1	+	0	304																											GCAGggtgacggtggtggtggtg	0.483													7	60	---	---	---	---					
