Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
HELZ2	85441	broad.mit.edu	37	20	62198566	62198566	+	Silent	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr20:62198566C>A	ENST00000467148.1	-	6	2214	c.2145G>T	c.(2143-2145)acG>acT	p.T715T	HELZ2_ENST00000427522.2_Silent_p.T146T	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		GGTGCAGCAGCGTGTGCTCGG	0.697000													6	33					0.0293803	0.029843	1	1	0
STX17	55014	broad.mit.edu	37	9	102691086	102691086	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr9:102691086G>T	ENST00000259400.6	+	3	286	c.150G>T	c.(148-150)aaG>aaT	p.K50N	RP11-60I3.4_ENST00000524512.1_RNA|STX17_ENST00000525640.1_Missense_Mutation_p.K50N|STX17_ENST00000534052.1_Missense_Mutation_p.K50N	NM_017919.2	NP_060389.2	P56962	STX17_HUMAN	syntaxin 17	50					intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum|integral to membrane|nucleolus	SNAP receptor activity			endometrium(2)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				TCTGGGACAAGTTGCATGAAG	0.338000													10	62					0.000978159	0.00103428	1	1	0
GPR1	2825	broad.mit.edu	37	2	207040991	207040991	+	Silent	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr2:207040991C>A	ENST00000407325.2	-	3	1343	c.981G>T	c.(979-981)ctG>ctT	p.L327L	GPR1_ENST00000437420.1_Silent_p.L327L	NM_001098199.1|NM_001261452.1|NM_001261453.1|NM_001261454.1|NM_001261455.1|NM_005279.3	NP_001091669.1|NP_001248381.1|NP_001248382.1|NP_001248383.1|NP_001248384.1|NP_005270.2	P46091	GPR1_HUMAN	G protein-coupled receptor 1	327						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	18		Lung NSC(271;7.93e-06)|Renal(323;0.000147)|Hepatocellular(293;0.000888)		UCEC - Uterine corpus endometrioid carcinoma (47;0.000241)|Epithelial(149;1.91e-37)|STAD - Stomach adenocarcinoma(1183;0.00178)|Lung(261;0.111)|LUSC - Lung squamous cell carcinoma(261;0.184)		TGACTTCCCACAGTGTGTACT	0.443000													12	92					1.5842e-08	1.96502e-08	1	1	0
HYAL4	23553	broad.mit.edu	37	7	123516999	123516999	+	Silent	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr7:123516999C>T	ENST00000223026.4	+	5	1874	c.1236C>T	c.(1234-1236)gaC>gaT	p.D412D	HYAL4_ENST00000476325.1_Silent_p.D412D	NM_012269.2	NP_036401.2	Q2M3T9	HYAL4_HUMAN	hyaluronoglucosaminidase 4	412					fusion of sperm to egg plasma membrane|glycosaminoglycan catabolic process	integral to membrane	hyalurononglucosaminidase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	23						CCTCTGAGGACGGGGAGTTTA	0.478000													32	97					0	0	1	0	0
BTBD7	55727	broad.mit.edu	37	14	93709111	93709111	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr14:93709111T>A	ENST00000334746.5	-	11	3214	c.2907A>T	c.(2905-2907)caA>caT	p.Q969H	BTBD7_ENST00000554565.1_Missense_Mutation_p.Q618H|BTBD7_ENST00000393170.2_Missense_Mutation_p.Q543H	NM_001002860.2	NP_001002860.2	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7	969										breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|skin(8)|upper_aerodigestive_tract(1)	35		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		AATATCCACCTTGCGAAGGGG	0.488000													20	91					0	0	1	0	0
SVIL	6840	broad.mit.edu	37	10	29777611	29777611	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr10:29777611G>T	ENST00000375398.2	-	25	4716	c.4267C>A	c.(4267-4269)Ctg>Atg	p.L1423M	SVIL_ENST00000538146.1_Missense_Mutation_p.L215M|SVIL_ENST00000535393.1_Missense_Mutation_p.L337M|SVIL_ENST00000375400.3_Missense_Mutation_p.L997M|SVIL_ENST00000355867.4_Missense_Mutation_p.L1423M			O95425	SVIL_HUMAN	supervillin	1423	Interaction with NEB.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(24)|lung(35)|ovary(8)|prostate(2)|skin(4)|stomach(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	112		Breast(68;0.103)				ACGCTCCGCAGGCTGACGTTG	0.507000													11	20					1.58986e-06	1.86448e-06	1	1	0
NGEF	25791	broad.mit.edu	37	2	233759576	233759576	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr2:233759576G>T	ENST00000264051.3	-	6	1157	c.879C>A	c.(877-879)aaC>aaA	p.N293K	NGEF_ENST00000539537.1_Missense_Mutation_p.N16K|NGEF_ENST00000373552.4_Missense_Mutation_p.N201K|NGEF_ENST00000409079.1_Missense_Mutation_p.N201K	NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	293	DH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		ACACGAGCAGGTTCAGACTCT	0.582000													10	107					1.08611e-07	1.33436e-07	1	1	0
ABCA13	154664	broad.mit.edu	37	7	48313691	48313691	+	Silent	SNP	A	A	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr7:48313691A>T	ENST00000435803.1	+	17	4452	c.4428A>T	c.(4426-4428)acA>acT	p.T1476T		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	1476					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						TACTTACTACAGTCTTTGAAA	0.279000													3	35					0	0	1	0	0
TSSC1	7260	broad.mit.edu	37	2	3358370	3358370	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr2:3358370T>A	ENST00000398659.4	-	2	217	c.77A>T	c.(76-78)gAt>gTt	p.D26V	TSSC1_ENST00000382125.4_Missense_Mutation_p.D26V|TSSC1_ENST00000443925.2_Missense_Mutation_p.D26V			Q53HC9	TSSC1_HUMAN	tumor suppressing subtransferable candidate 1	26							protein binding			breast(2)|kidney(2)|large_intestine(3)|lung(9)|prostate(1)|skin(1)	18	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)	all_cancers(51;0.212)		OV - Ovarian serous cystadenocarcinoma(76;0.00877)|Epithelial(75;0.0283)|all cancers(51;0.0464)		CCGAATGGCATCTGTTTCTGC	0.358000													16	64					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38406983	38406983	+	Silent	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr5:38406983C>T	ENST00000322350.5	+	8	1228	c.882C>T	c.(880-882)agC>agT	p.S294S	EGFLAM_ENST00000336740.6_Silent_p.S60S|EGFLAM_ENST00000354891.3_Silent_p.S294S|EGFLAM_ENST00000397202.2_Intron	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	294						cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					TGGTGGAAAGCAAGAAGATGT	0.488000													21	91					0	0	1	0	0
SORBS2	8470	broad.mit.edu	37	4	186515086	186515086	+	Nonsense_Mutation	SNP	G	G	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr4:186515086G>A	ENST00000431808.1	-	20	3651	c.3088C>T	c.(3088-3090)Cag>Tag	p.Q1030*	SORBS2_ENST00000284776.7_Nonsense_Mutation_p.Q1030*|RP11-301L8.2_ENST00000411847.1_RNA|SORBS2_ENST00000448662.2_Nonsense_Mutation_p.Q591*|SORBS2_ENST00000418609.1_Nonsense_Mutation_p.Q934*|SORBS2_ENST00000449407.2_Nonsense_Mutation_p.Q574*|SORBS2_ENST00000393528.3_Nonsense_Mutation_p.Q596*|SORBS2_ENST00000355634.5_Nonsense_Mutation_p.Q1130*|SORBS2_ENST00000437304.2_Nonsense_Mutation_p.Q754*|SORBS2_ENST00000319471.9_Nonsense_Mutation_p.Q661*			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	1030						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		ACAGGACGCTGTGGCTGAAAT	0.333000													20	72					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20335521	20335521	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr16:20335521G>A	ENST00000302555.5	-	3	301	c.152C>T	c.(151-153)cCt>cTt	p.P51L	GP2_ENST00000381360.5_Intron|GP2_ENST00000381362.4_Missense_Mutation_p.P51L|GP2_ENST00000341642.5_Intron			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	51						anchored to membrane|extracellular region|plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						TGGGGTGCCAGGAGCTCCGCA	0.557000													11	68					0	0	1	0	0
HIST2H2BA	337875	broad.mit.edu	37	1	120906120	120906120	+	RNA	SNP	C	C	G	rs139709905	by1000genomes	TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr1:120906120C>G	ENST00000430394.1	+	0	93					NR_027337.1																						AGAAGAAGGACGGCGAGAAGC	0.572000													5	127					0	0	1	0	0
PHF23	79142	broad.mit.edu	37	17	7140034	7140034	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr17:7140034G>A	ENST00000320316.3	-	4	438	c.212C>T	c.(211-213)gCg>gTg	p.A71V	PHF23_ENST00000576955.1_5'UTR|PHF23_ENST00000571362.1_Intron|PHF23_ENST00000570753.1_5'UTR|PHF23_ENST00000454255.2_Missense_Mutation_p.A67V	NM_024297.2	NP_077273.2	Q9BUL5	PHF23_HUMAN	PHD finger protein 23	71							zinc ion binding			breast(4)|kidney(2)|large_intestine(6)|lung(3)	15						ACTGTCGGCCGCACTCTCTCC	0.552000													5	122					0	0	1	0	0
TRO	7216	broad.mit.edu	37	X	54955036	54955036	+	Splice_Site	SNP	G	G	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chrX:54955036G>T	ENST00000173898.7	+	12	1991	c.1878_splice	c.e12-1	p.V627_splice	TRO_ENST00000375041.2_Splice_Site_p.V230_splice|TRO_ENST00000319167.8_Splice_Site_p.V627_splice|TRO_ENST00000375022.4_Splice_Site_p.V627_splice|TRO_ENST00000420798.2_Splice_Site_p.V158_splice|TRO_ENST00000399736.1_Splice_Site_p.V230_splice	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	627	MAGE.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						CCCATTTCAGGTGCAGAAGAA	0.453000													12	30					3.07112e-06	3.47521e-06	1	1	0
CD300LG	146894	broad.mit.edu	37	17	41926210	41926210	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr17:41926210G>A	ENST00000317310.4	+	2	369	c.328G>A	c.(328-330)Gaa>Aaa	p.E110K	CD300LG_ENST00000539718.1_Missense_Mutation_p.E110K|CD300LG_ENST00000293396.8_Missense_Mutation_p.E110K|CD300LG_ENST00000588884.1_Missense_Mutation_p.E110K|CD300LG_ENST00000586233.1_Missense_Mutation_p.E110K|CD300LG_ENST00000377203.4_Missense_Mutation_p.E110K	NM_145273.3	NP_660316.2	Q6UXG3	CLM9_HUMAN	CD300 molecule-like family member g	110	Ig-like V-type.					apical plasma membrane|basolateral plasma membrane|integral to membrane|multivesicular body membrane	receptor activity	p.E110K(3)		central_nervous_system(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(5)|skin(4)	19		Breast(137;0.0199)		BRCA - Breast invasive adenocarcinoma(366;0.115)		GTGTGGGGTCGAAAAACGGGG	0.592000													33	89					0	0	1	0	0
DSG4	147409	broad.mit.edu	37	18	28991154	28991154	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr18:28991154G>C	ENST00000359747.4	+	14	2184	c.2155G>C	c.(2155-2157)Gca>Cca	p.A719P	RP11-534N16.1_ENST00000581856.1_RNA|RP11-534N16.1_ENST00000578477.1_RNA|DSG4_ENST00000308128.4_Intron	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	700					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CGCGCTGCAGGCAACTCCAGC	0.577000													12	50					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22664141	22664141	+	RNA	SNP	G	G	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr22:22664141G>A	ENST00000426066.1	+	0	664					NR_027293.1																						AAATTTGAAGGTGCTGTGATT	0.448000													4	99					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171227255	171227255	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr1:171227255C>A	ENST00000354841.4	+	1	160	c.29C>A	c.(28-30)gCt>gAt	p.A10D	FMO1_ENST00000402921.2_Missense_Mutation_p.A10D|FMO1_ENST00000367750.3_Missense_Mutation_p.A10D|FMO1_ENST00000469112.1_3'UTR			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	10					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATTGTGGGAGCTGGGGTCAGC	0.567000													32	76					9.78306e-22	1.32844e-21	1	1	0
KCNA4	3739	broad.mit.edu	37	11	30033986	30033986	+	Silent	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr11:30033986C>A	ENST00000328224.6	-	2	1473	c.240G>T	c.(238-240)cgG>cgT	p.R80R		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	80						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						TCCGACTACCCCGGCTGCTCT	0.642000													17	58					3.32936e-07	4.05177e-07	1	1	0
MX2	4600	broad.mit.edu	37	21	42748859	42748859	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr21:42748859C>T	ENST00000330714.3	+	2	210	c.26C>T	c.(25-27)cCc>cTc	p.P9L	MX2_ENST00000543692.1_Missense_Mutation_p.P9L	NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)	9					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				AAGCCTTGGCCCTACCGGAGG	0.517000													21	97					0	0	1	0	0
IGHV4-31	28396	broad.mit.edu	37	14	106805393	106805393	+	RNA	SNP	C	C	G			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr14:106805393C>G	ENST00000438142.2	-	0	241																											CTGGCGGATCCAGCTCCAGTA	0.572000													14	392					0	0	1	0	0
MMP9	4318	broad.mit.edu	37	20	44639909	44639909	+	Silent	SNP	G	G	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr20:44639909G>T	ENST00000372330.3	+	5	796	c.777G>T	c.(775-777)acG>acT	p.T259T		NM_004994.2	NP_004985.2	P14780	MMP9_HUMAN	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	259	Fibronectin type-II 1.				collagen catabolic process|macrophage differentiation|positive regulation of keratinocyte migration|proteolysis	extracellular space|proteinaceous extracellular matrix	collagen binding|metalloendopeptidase activity|zinc ion binding			breast(2)|endometrium(4)|large_intestine(14)|liver(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(3)	46		Myeloproliferative disorder(115;0.0122)			Glucosamine(DB01296)|Marimastat(DB00786)|Minocycline(DB01017)|Simvastatin(DB00641)	GCAGTACCACGGCCAACTACG	0.677000													18	122					2.37509e-13	3.09482e-13	1	1	0
PCDHB6	56130	broad.mit.edu	37	5	140531421	140531421	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr5:140531421G>A	ENST00000231136.1	+	1	1583	c.1583G>A	c.(1582-1584)cGc>cAc	p.R528H	PCDHB6_ENST00000543635.1_Missense_Mutation_p.R392H	NM_018939.2	NP_061762.1	Q9Y5E3	PCDB6_HUMAN		528	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			cervix(1)|endometrium(14)|kidney(6)|large_intestine(16)|liver(1)|lung(33)|ovary(1)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	84			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCGAGTTCCGCGTGGGCGCC	0.657000													6	145					0	0	1	0	0
C6orf118	168090	broad.mit.edu	37	6	165715557	165715557	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr6:165715557C>T	ENST00000230301.8	-	2	274	c.254G>A	c.(253-255)cGg>cAg	p.R85Q	C6orf118_ENST00000543069.1_5'UTR	NM_144980.3	NP_659417.2	Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	85										breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CCCCTTGGGCCGGTGGGCATT	0.652000													29	107					0	0	1	0	0
IREB2	3658	broad.mit.edu	37	15	78780596	78780596	+	Silent	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr15:78780596C>T	ENST00000258886.8	+	15	2018	c.1869C>T	c.(1867-1869)gcC>gcT	p.A623A		NM_004136.2	NP_004127.1	P48200	IREB2_HUMAN	iron-responsive element binding protein 2	623							4 iron, 4 sulfur cluster binding|metal ion binding|protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(14)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	41				UCEC - Uterine corpus endometrioid carcinoma (272;0.232)		GTGTTCGTGCCAATTATCTTG	0.383000													25	71					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69136826	69136826	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr8:69136826G>T	ENST00000288368.4	+	39	5017	c.4740G>T	c.(4738-4740)ttG>ttT	p.L1580F		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1580					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CGAAGAATTTGGGAGTCAGAG	0.468000													9	88					0.000673444	0.000717969	1	1	0
ACTN4	81	broad.mit.edu	37	19	39214854	39214854	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr19:39214854C>T	ENST00000252699.2	+	15	1826	c.1750C>T	c.(1750-1752)Cgc>Tgc	p.R584C	ACTN4_ENST00000424234.2_Missense_Mutation_p.R194C|ACTN4_ENST00000390009.3_Missense_Mutation_p.R365C	NM_004924.4	NP_004915.2	O43707	ACTN4_HUMAN	actinin, alpha 4	584					platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(1)|skin(1)|urinary_tract(3)	30	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CGATAGGGAGCGCGAGGCCAT	0.657000													5	58					0	0	1	0	0
OR2T1	26696	broad.mit.edu	37	1	248570365	248570365	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr1:248570365G>T	ENST00000366474.1	+	1	1070	c.1070G>T	c.(1069-1071)aGg>aTg	p.R357M		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	357					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCCTTGGGGAGGTTCAAGGGT	0.522000													9	250					7.48243e-07	9.02087e-07	1	1	0
APAF1	317	broad.mit.edu	37	12	99056506	99056506	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr12:99056506G>A	ENST00000357310.1	+	7	1454	c.877G>A	c.(877-879)Gaa>Aaa	p.E293K	APAF1_ENST00000549007.1_Missense_Mutation_p.E293K|APAF1_ENST00000359972.2_Missense_Mutation_p.E282K|APAF1_ENST00000547045.1_Missense_Mutation_p.E293K|APAF1_ENST00000552268.1_Missense_Mutation_p.E293K|APAF1_ENST00000551964.1_Missense_Mutation_p.E293K|APAF1_ENST00000339433.3_Missense_Mutation_p.E293K|APAF1_ENST00000333991.1_Missense_Mutation_p.E293K|APAF1_ENST00000550527.1_Missense_Mutation_p.E282K	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	293	NB-ARC.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	AAAAGGACTTGAAATTTTATC	0.318000													8	48					0	0	1	0	0
EXOC5	10640	broad.mit.edu	37	14	57698288	57698288	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr14:57698288C>T	ENST00000413566.2	-	11	1443	c.1084G>A	c.(1084-1086)Gct>Act	p.A362T	EXOC5_ENST00000340918.7_Missense_Mutation_p.A297T	NM_006544.3	NP_006535.1	O00471	EXOC5_HUMAN	exocyst complex component 5	362					exocytosis|post-Golgi vesicle-mediated transport|protein transport|vesicle docking	cytoplasm				breast(3)|endometrium(1)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	22						AGGATCATAGCACTTCTGCTT	0.348000													11	40					0	0	1	0	0
PDK2	5164	broad.mit.edu	37	17	48186757	48186757	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr17:48186757A>G	ENST00000503176.1	+	10	1237	c.1076A>G	c.(1075-1077)tAt>tGt	p.Y359C	PDK2_ENST00000007708.3_Missense_Mutation_p.Y295C	NM_002611.4	NP_002602.2	Q15119	PDK2_HUMAN	pyruvate dehydrogenase kinase, isozyme 2	359	Histidine kinase.				glucose metabolic process|peptidyl-histidine phosphorylation|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|nucleus	ATP binding|pyruvate dehydrogenase (acetyl-transferring) kinase activity|two-component sensor activity			central_nervous_system(4)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	20						GCTGTCATCTATCTCAAGGTG	0.577000									Autosomal Dominant Polycystic Kidney Disease				13	41					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058135	152058135	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr1:152058135C>T	ENST00000368806.1	-	3	2087	c.2023G>A	c.(2023-2025)Gcc>Acc	p.A675T		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	675							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TCATCCAGGGCACCTGTGATC	0.502000													41	230					0	0	1	0	0
SYTL2	54843	broad.mit.edu	37	11	85445176	85445176	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr11:85445176C>T	ENST00000316356.4	-	7	1760	c.1196G>A	c.(1195-1197)aGc>aAc	p.S399N	SYTL2_ENST00000389960.4_Missense_Mutation_p.S398N|SYTL2_ENST00000527523.1_Missense_Mutation_p.S350N|SYTL2_ENST00000528231.1_Missense_Mutation_p.S398N|SYTL2_ENST00000524452.1_Missense_Mutation_p.S398N			Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2	398					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(22)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TACATATGGGCTTGAGGTTGA	0.403000													32	74					0	0	1	0	0
SNTG1	54212	broad.mit.edu	37	8	51503459	51503459	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr8:51503459C>A	ENST00000522124.1	+	13	1492	c.831C>A	c.(829-831)aaC>aaA	p.N277K	SNTG1_ENST00000517473.1_Missense_Mutation_p.N277K|SNTG1_ENST00000518864.1_Missense_Mutation_p.N277K|SNTG1_ENST00000276467.5_Missense_Mutation_p.N277K	NM_018967.2	NP_061840.1	Q9NSN8	SNTG1_HUMAN	syntrophin, gamma 1	277					cell communication	cytoplasm|cytoskeleton|nucleus|ruffle membrane|syntrophin complex	actin binding|protein C-terminus binding			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(36)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	66		all_cancers(86;0.00754)|all_epithelial(80;9.76e-05)|Lung NSC(129;0.000865)|all_lung(136;0.00249)|Colorectal(162;0.22)				TCAACAGAAACTTTCCTGTAA	0.279000													4	36					0.184627	0.184627	1	1	0
GOLGB1	2804	broad.mit.edu	37	3	121414126	121414126	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr3:121414126C>A	ENST00000393667.3	-	13	5354	c.5244G>T	c.(5242-5244)caG>caT	p.Q1748H	GOLGB1_ENST00000340645.5_Missense_Mutation_p.Q1743H	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	1743					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		ACATTAAAGACTGAAACTTCT	0.383000													40	78					6.19805e-25	8.5973e-25	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141135789	141135789	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr2:141135789C>A	ENST00000389484.3	-	68	11569	c.10598G>T	c.(10597-10599)tGg>tTg	p.W3533L		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3533	LDL-receptor class A 26.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.W3533L(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TCCATCACACCAAAACCTTGA	0.398000										TSP Lung(27;0.18)			6	47					0.0477658	0.0481389	1	1	0
CYP11B1	1584	broad.mit.edu	37	8	143956560	143956560	+	Missense_Mutation	SNP	C	C	T	rs4998896		TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr8:143956560C>T	ENST00000292427.4	-	8	1243	c.1211G>A	c.(1210-1212)cGc>cAc	p.R404H	CYP11B1_ENST00000377675.3_Missense_Mutation_p.R475H|CYP11B1_ENST00000517471.1_Intron	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	404			R -> H (in dbSNP:rs4998896).		aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GAGGAACACGCGCACCAATGT	0.647000									Familial Hyperaldosteronism type I				8	129					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32188853	32188853	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr6:32188853C>T	ENST00000375023.3	-	4	839	c.701G>A	c.(700-702)cGg>cAg	p.R234Q		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	234	EGF-like 6.				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GGGTCCTGCCCGCAGCTCACA	0.647000													4	56					0	0	1	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51918586	51918586	+	Silent	SNP	G	G	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr19:51918586G>A	ENST00000353836.5	-	7	1400	c.1179C>T	c.(1177-1179)acC>acT	p.T393T	SIGLEC10_ENST00000441969.3_Silent_p.T335T|SIGLEC10_ENST00000439889.2_Silent_p.T335T|SIGLEC10_ENST00000436984.2_Silent_p.T345T|SIGLEC10_ENST00000432469.2_Silent_p.T310T|SIGLEC10_ENST00000356298.5_Silent_p.T393T|SIGLEC10_ENST00000525998.1_Silent_p.T303T|SIGLEC10_ENST00000339313.5_Silent_p.T393T|SIGLEC10_ENST00000442846.3_Silent_p.T245T	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	393	Ig-like C2-type 3.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding	p.T335T(1)|p.T393T(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		GTCCCCTCTGGGTCCAGCTCA	0.642000													19	45					0	0	1	0	0
RABEPK	10244	broad.mit.edu	37	9	127982816	127982816	+	Splice_Site	SNP	A	A	C			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr9:127982816A>C	ENST00000373544.1	+	7	601		c.e7-1		RABEPK_ENST00000259460.8_Splice_Site|RABEPK_ENST00000373538.3_Splice_Site|RABEPK_ENST00000394125.4_Splice_Site|RABEPK_ENST00000394124.4_Splice_Site			Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs						receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				NS(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	15						TCTCTGGCCCAGAAACCAGGA	0.532000													15	64					0	0	1	0	0
ADAMTS5	11096	broad.mit.edu	37	21	28337622	28337622	+	Silent	SNP	G	G	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr21:28337622G>T	ENST00000284987.5	-	1	1210	c.1089C>A	c.(1087-1089)atC>atA	p.I363I		NM_007038.3	NP_008969.2	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 5	363	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	72						GAGTAAACAGGATAGCTGCAT	0.557000													13	136					7.93312e-07	9.47567e-07	1	1	0
FGF3	2248	broad.mit.edu	37	11	69625448	69625448	+	Silent	SNP	G	G	A	rs116162988	by1000genomes	TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr11:69625448G>A	ENST00000334134.2	-	3	435	c.345C>T	c.(343-345)tgC>tgT	p.C115C		NM_005247.2	NP_005238.1	P11487	FGF3_HUMAN	fibroblast growth factor 3	115					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of cardiac muscle tissue development|positive regulation of cell division|positive regulation of cell proliferation	extracellular region	growth factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|urinary_tract(1)	13			LUSC - Lung squamous cell carcinoma(11;5.05e-15)|STAD - Stomach adenocarcinoma(18;0.0278)			CCACAAACTCGCACTCGGCGC	0.652000													18	51					0	0	1	0	0
LSP1	4046	broad.mit.edu	37	11	1905162	1905162	+	Splice_Site	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr11:1905162C>T	ENST00000406638.2	+	5	1615	c.312_splice	c.e5-1	p.H105_splice	LSP1_ENST00000485341.1_3'UTR|LSP1_ENST00000381775.1_Splice_Site_p.H295_splice|LSP1_ENST00000405957.2_Splice_Site_p.H105_splice|LSP1_ENST00000311604.3_Splice_Site_p.H167_splice	NM_001013254.1|NM_001013255.1	NP_001013272.1|NP_001013273.1	P33241	LSP1_HUMAN	lymphocyte-specific protein 1	167					cellular component movement|cellular defense response	actin cytoskeleton|Golgi apparatus|plasma membrane	actin binding|signal transducer activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|Lung(200;0.0729)|LUSC - Lung squamous cell carcinoma(625;0.0856)		TTTTTTCTAGCACCAGAAATG	0.567000													19	163					0	0	1	0	0
MTUS1	57509	broad.mit.edu	37	8	17612089	17612089	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr8:17612089C>T	ENST00000381869.3	-	2	1701	c.1228G>A	c.(1228-1230)Gga>Aga	p.G410R	MTUS1_ENST00000262102.6_Missense_Mutation_p.G410R|MTUS1_ENST00000381862.3_Missense_Mutation_p.G410R|MTUS1_ENST00000519263.1_Missense_Mutation_p.G410R	NM_001001925.2	NP_001001925.1	Q9ULD2	MTUS1_HUMAN	microtubule associated tumor suppressor 1	410						Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(14)|lung(8)|ovary(1)|skin(2)|urinary_tract(1)	36				Colorectal(111;0.0778)		CAAGTCAGTCCAAATGACGAG	0.438000													24	61					0	0	1	0	0
OLFM1	10439	broad.mit.edu	37	9	138011949	138011949	+	Silent	SNP	G	G	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr9:138011949G>T	ENST00000252854.4	+	6	1516	c.1329G>T	c.(1327-1329)ctG>ctT	p.L443L	OLFM1_ENST00000371796.3_Silent_p.L434L|OLFM1_ENST00000371793.3_Silent_p.L461L	NM_014279.4	NP_055094.1	Q99784	NOE1_HUMAN	olfactomedin 1	461	Olfactomedin-like.				nervous system development	endoplasmic reticulum lumen	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)	21		Myeloproliferative disorder(178;0.0333)		Epithelial(140;5.49e-08)|OV - Ovarian serous cystadenocarcinoma(145;9.68e-08)|all cancers(34;1.88e-07)		ACCGGGCCCTGTATGCCTGGA	0.557000													9	88					0.00621372	0.00646427	1	1	0
GRIK1	2897	broad.mit.edu	37	21	30953832	30953832	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr21:30953832G>T	ENST00000399914.1	-	12	2301	c.1780C>A	c.(1780-1782)Cca>Aca	p.P594T	GRIK1_ENST00000327783.4_Missense_Mutation_p.P609T|GRIK1_ENST00000399913.1_Missense_Mutation_p.P609T|GRIK1_ENST00000399909.1_Missense_Mutation_p.P594T|GRIK1_ENST00000535441.1_Missense_Mutation_p.P611T|GRIK1_ENST00000309434.7_Missense_Mutation_p.P611T|GRIK1_ENST00000389125.3_Missense_Mutation_p.P594T|GRIK1_ENST00000389124.2_Missense_Mutation_p.P609T|GRIK1_ENST00000399907.1_Missense_Mutation_p.P609T			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	609					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GGGTTGCATGGGTGGGGGTTA	0.448000													17	73					8.00594e-06	8.90316e-06	1	1	0
FLG	2312	broad.mit.edu	37	1	152277431	152277431	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr1:152277431C>G	ENST00000368799.1	-	3	9966	c.9931G>C	c.(9931-9933)Gac>Cac	p.D3311H	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	3311	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTGGAGCTGTCTGCTGACTGC	0.562000									Ichthyosis				155	841					0	0	1	0	0
C11orf85	283129	broad.mit.edu	37	11	64717893	64717893	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr11:64717893G>A	ENST00000301896.5	-	5	230	c.157C>T	c.(157-159)Cgc>Tgc	p.R53C	C11orf85_ENST00000536065.1_5'UTR|C11orf85_ENST00000530444.1_Intron|C11orf85_ENST00000432175.1_Missense_Mutation_p.R53C	NM_001037225.1	NP_001032302.1	Q3KP22	CK085_HUMAN	chromosome 11 open reading frame 85	53										breast(2)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(2)	7						AAGACCACGCGGACAGAATCC	0.373000													11	48					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141135788	141135788	+	Nonsense_Mutation	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr2:141135788C>T	ENST00000389484.3	-	68	11570	c.10599G>A	c.(10597-10599)tgG>tgA	p.W3533*		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3533	LDL-receptor class A 26.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTCCATCACACCAAAACCTTG	0.398000										TSP Lung(27;0.18)			6	49					0	0	1	0	0
SPNS1	83985	broad.mit.edu	37	16	28989271	28989271	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr16:28989271A>C	ENST00000311008.11	+	3	727	c.350A>C	c.(349-351)tAc>tCc	p.Y117S	SPNS1_ENST00000352260.7_Missense_Mutation_p.Y95S|RP11-264B17.4_ENST00000567209.1_RNA|SPNS1_ENST00000334536.8_Missense_Mutation_p.Y117S|SPNS1_ENST00000323081.8_Missense_Mutation_p.Y44S|SPNS1_ENST00000565975.1_Missense_Mutation_p.Y162S|RP11-264B17.3_ENST00000569969.1_RNA|SPNS1_ENST00000561868.1_Intron	NM_032038.2	NP_114427.1	Q9H2V7	SPNS1_HUMAN	spinster homolog 1 (Drosophila)	117					lipid transport|transmembrane transport	integral to membrane|mitochondrial inner membrane	protein binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)|urinary_tract(1)	21						GTGTTTGGCTACCTGGGTGAC	0.577000											OREG0023711	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	81					0	0	1	0	0
MIR890	100126303	broad.mit.edu	37	X	145075810	145075810	+	RNA	SNP	A	A	G			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chrX:145075810A>G	ENST00000401256.1	-	0	59					NR_030589.1																						TACTCTACTCAGAAAGGGAAT	0.478000													25	59					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139910292	139910292	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr9:139910292G>A	ENST00000265662.5	-	23	3496	c.3349C>T	c.(3349-3351)Cgg>Tgg	p.R1117W	ABCA2_ENST00000371605.3_Missense_Mutation_p.R1116W|ABCA2_ENST00000341511.6_Missense_Mutation_p.R1117W			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1116	ABC transporter 1.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		AGTGAGTGCCGTTTGTTGGAG	0.662000													5	50					0	0	1	0	0
DHRS9	10170	broad.mit.edu	37	2	169952102	169952102	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr2:169952102C>T	ENST00000327239.4	+	8	2289	c.785C>T	c.(784-786)tCt>tTt	p.S262F	DHRS9_ENST00000357546.2_Missense_Mutation_p.S262F|DHRS9_ENST00000428522.1_Missense_Mutation_p.S262F|DHRS9_ENST00000421653.1_Missense_Mutation_p.S115F|DHRS9_ENST00000602501.1_Missense_Mutation_p.S262F|DHRS9_ENST00000412271.1_Missense_Mutation_p.S262F|DHRS9_ENST00000432060.2_Missense_Mutation_p.S322F|DHRS9_ENST00000436483.2_Missense_Mutation_p.S262F	NM_005771.4	NP_005762.2	Q9BPW9	DHRS9_HUMAN	dehydrogenase/reductase (SDR family) member 9	262					9-cis-retinoic acid biosynthetic process|androgen metabolic process|epithelial cell differentiation|progesterone metabolic process|retinol metabolic process	integral to endoplasmic reticulum membrane|microsome	alcohol dehydrogenase (NAD) activity|binding|racemase and epimerase activity|retinol dehydrogenase activity|testosterone dehydrogenase (NAD+) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)	13						ATGGACCTCTCTCCGGTGGTA	0.428000													20	166					0	0	1	0	0
ZXDC	79364	broad.mit.edu	37	3	126181064	126181064	+	Splice_Site	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr3:126181064C>A	ENST00000389709.3	-	6	1495		c.e6-1		ZXDC_ENST00000336332.5_Splice_Site	NM_025112.4	NP_079388.3	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C						positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(1)	17				GBM - Glioblastoma multiforme(114;0.155)		GGTAAGAGATCTGAAAAAAAA	0.458000													25	59					1.26454e-06	1.49657e-06	1	1	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	A	rs121913530		TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr12:25398285C>A	ENST00000311936.3	-	2	225	c.34G>T	c.(34-36)Ggt>Tgt	p.G12C	KRAS_ENST00000557334.1_Missense_Mutation_p.G12C|KRAS_ENST00000556131.1_Missense_Mutation_p.G12C|KRAS_ENST00000256078.4_Missense_Mutation_p.G12C	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			6	30					2.0095e-06	2.31451e-06	1	1	0
OR5T1	390155	broad.mit.edu	37	11	56043303	56043303	+	Silent	SNP	G	G	C			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr11:56043303G>C	ENST00000313033.2	+	1	275	c.189G>C	c.(187-189)ggG>ggC	p.G63G		NM_001004745.1	NP_001004745.1	Q8NG75	OR5T1_HUMAN	olfactory receptor, family 5, subfamily T, member 1	63					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(27)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	43	Esophageal squamous(21;0.00448)					CGATCATTGGGGATTTCTGGC	0.358000													8	95					0	0	1	0	0
KLHL38	340359	broad.mit.edu	37	8	124664963	124664963	+	Silent	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr8:124664963C>A	ENST00000325995.7	-	1	227	c.204G>T	c.(202-204)cgG>cgT	p.R68R	CTD-2552K11.2_ENST00000524355.1_RNA	NM_001081675.2	NP_001075144.2	Q2WGJ6	KLH38_HUMAN	kelch-like family member 38	68	BTB.									breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(16)|pancreas(1)|prostate(3)|stomach(1)	38						CACTCTTCTCCCGGAAGCTGC	0.597000													45	54					1.23103e-26	1.74508e-26	1	1	0
CUEDC1	404093	broad.mit.edu	37	17	55962667	55962667	+	Missense_Mutation	SNP	T	T	C			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr17:55962667T>C	ENST00000577830.1	-	2	672	c.259A>G	c.(259-261)Atg>Gtg	p.M87V	CUEDC1_ENST00000407144.2_Missense_Mutation_p.M87V|CUEDC1_ENST00000577840.1_Intron|CUEDC1_ENST00000360238.2_Missense_Mutation_p.M87V	NM_001271875.1	NP_001258804.1	Q9NWM3	CUED1_HUMAN	CUE domain containing 1	87	CUE.									endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(3)	12						TCCAGGTTCATCTGCAGCAGC	0.632000													13	75					0	0	1	0	0
UCP1	7350	broad.mit.edu	37	4	141481127	141481127	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr4:141481127C>A	ENST00000262999.3	-	6	922	c.847G>T	c.(847-849)Gtc>Ttc	p.V283F		NM_021833.4	NP_068605.1	P25874	UCP1_HUMAN	uncoupling protein 1 (mitochondrial, proton carrier)	283	Purine nucleotide binding (By similarity).				brown fat cell differentiation|cellular lipid metabolic process|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding			NS(1)|breast(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)|stomach(1)	16	all_hematologic(180;0.162)					AACATAATGACGTTCCAGGAT	0.363000													5	76					0.000602214	0.00064738	1	1	0
KCNT2	343450	broad.mit.edu	37	1	196197422	196197422	+	Nonsense_Mutation	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr1:196197422C>A	ENST00000367433.5	-	27	3369	c.3268G>T	c.(3268-3270)Gag>Tag	p.E1090*	KCNT2_ENST00000367431.4_Nonsense_Mutation_p.E1048*|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000451324.2_3'UTR|KCNT2_ENST00000294725.8_Nonsense_Mutation_p.E1114*			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	1114						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						CGACTGGGCTCACTGTTTGGA	0.348000													19	44					7.88262e-20	1.05923e-19	1	1	0
OR4C15	81309	broad.mit.edu	37	11	55321896	55321896	+	Silent	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr11:55321896C>T	ENST00000314644.2	+	1	114	c.114C>T	c.(112-114)tgC>tgT	p.C38C		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						GTCCTAATTGCAGACTATACA	0.383000										HNSCC(20;0.049)			14	167					0	0	1	0	0
ATL3	25923	broad.mit.edu	37	11	63398539	63398539	+	Silent	SNP	A	A	G			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr11:63398539A>G	ENST00000398868.3	-	12	1788	c.1512T>C	c.(1510-1512)gaT>gaC	p.D504D	ATL3_ENST00000538786.1_Silent_p.D486D|ATL3_ENST00000332645.4_Silent_p.D531D	NM_015459.3	NP_056274.3	Q6DD88	ATLA3_HUMAN	atlastin GTPase 3	504					endoplasmic reticulum organization|Golgi organization|protein homooligomerization	endoplasmic reticulum membrane|integral to membrane	GTP binding|GTPase activity|identical protein binding			endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	11						CGGCACCAAAATCAATAGCTC	0.458000													7	40					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31426269	31426269	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr16:31426269G>A	ENST00000389202.2	+	18	2289	c.2240G>A	c.(2239-2241)cGt>cAt	p.R747H		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	747					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						CAGAACCTGCGTCCTGTGCTG	0.547000													30	79					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170967428	170967428	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr1:170967428G>C	ENST00000367758.3	+	15	1708	c.1609G>C	c.(1609-1611)Gac>Cac	p.D537H	MROH9_ENST00000367759.4_Intron	NM_025063.2	NP_079339.2			maestro heat-like repeat family member 9																		GAGTTTTGTAGACTGTGAACA	0.393000													22	170					0	0	1	0	0
GRIK1	2897	broad.mit.edu	37	21	30933956	30933956	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr21:30933956C>T	ENST00000399914.1	-	14	2821	c.2300G>A	c.(2299-2301)gGa>gAa	p.G767E	GRIK1_ENST00000327783.4_Missense_Mutation_p.G782E|GRIK1_ENST00000399913.1_Missense_Mutation_p.G782E|GRIK1_ENST00000399909.1_Missense_Mutation_p.G767E|GRIK1_ENST00000535441.1_Missense_Mutation_p.G784E|GRIK1_ENST00000309434.7_Missense_Mutation_p.G784E|GRIK1_ENST00000389125.3_Missense_Mutation_p.G767E|GRIK1_ENST00000389124.2_Missense_Mutation_p.G782E|GRIK1_ENST00000399907.1_Missense_Mutation_p.G782E			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	782					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	AATAGGTGTTCCCACTCCGTA	0.483000													7	52					0	0	1	0	0
LHX9	56956	broad.mit.edu	37	1	197890681	197890681	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr1:197890681G>T	ENST00000367390.3	+	4	625	c.598G>T	c.(598-600)Ggc>Tgc	p.G200C	LHX9_ENST00000367387.4_Missense_Mutation_p.G209C|LHX9_ENST00000337020.2_Missense_Mutation_p.G209C|LHX9_ENST00000561173.1_Missense_Mutation_p.G215C|LHX9_ENST00000367391.1_Missense_Mutation_p.G200C	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	209					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						GGCCAAGAGCGGCGGCCTGGC	0.637000													21	35					4.35082e-09	5.44908e-09	1	1	0
BRINP1	1620	broad.mit.edu	37	9	121930200	121930200	+	Missense_Mutation	SNP	A	A	C			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr9:121930200A>C	ENST00000265922.3	-	8	1909	c.1448T>G	c.(1447-1449)tTc>tGc	p.F483C	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		483					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						CAGGTCCTGGAAGTCCAGGTC	0.557000													4	62					0	0	1	0	0
GRPEL1	80273	broad.mit.edu	37	4	7069712	7069712	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr4:7069712C>A	ENST00000264954.4	-	1	212	c.48G>T	c.(46-48)ttG>ttT	p.L16F		NM_025196.2	NP_079472.1	Q9HAV7	GRPE1_HUMAN	GrpE-like 1, mitochondrial (E. coli)	16					protein folding|protein import into mitochondrial matrix	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5						GAGACAACGCCAAAGCAGGAA	0.697000													3	37					0.00909568	0.00938674	1	1	0
TNN	63923	broad.mit.edu	37	1	175048576	175048576	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr1:175048576G>A	ENST00000239462.4	+	3	630	c.517G>A	c.(517-519)Ggg>Agg	p.G173R		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	173	EGF-like 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GGCCTGCCCCGGGGCGTGCAG	0.741000													5	10					0	0	1	0	0
SYNDIG1L	646658	broad.mit.edu	37	14	74874276	74874276	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr14:74874276C>A	ENST00000331628.3	-	4	926	c.679G>T	c.(679-681)Gct>Tct	p.A227S	SYNDIG1L_ENST00000554823.1_Missense_Mutation_p.A227S	NM_001105579.1	NP_001099049.1	A6NDD5	SYN1L_HUMAN	synapse differentiation inducing 1-like	227					response to biotic stimulus	Golgi apparatus|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(8)|pancreas(1)|prostate(1)|skin(1)	14						GCTGCCAGAGCCACCACCACA	0.657000													26	75					3.73148e-12	4.81361e-12	1	1	0
SSFA2	6744	broad.mit.edu	37	2	182781154	182781154	+	Splice_Site	SNP	G	G	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr2:182781154G>T	ENST00000431877.2	+	11	2966	c.2787_splice	c.e11+1	p.Q929_splice	SSFA2_ENST00000409136.1_Splice_Site_p.Q438_splice|SSFA2_ENST00000320370.7_Splice_Site_p.Q929_splice|SSFA2_ENST00000409001.1_Splice_Site_p.Q929_splice|SSFA2_ENST00000428267.2_Splice_Site_p.Q776_splice	NM_001130445.1	NP_001123917.1	P28290	SSFA2_HUMAN	sperm specific antigen 2	929						cytoplasm|plasma membrane	actin binding			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(18)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	38			OV - Ovarian serous cystadenocarcinoma(117;0.0856)			ATCTTTCACAGGTATGAGAAA	0.383000													7	69					2.0095e-06	2.31451e-06	1	1	0
CHST11	50515	broad.mit.edu	37	12	105151376	105151376	+	Missense_Mutation	SNP	A	A	G			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr12:105151376A>G	ENST00000303694.5	+	3	1293	c.854A>G	c.(853-855)gAt>gGt	p.D285G	CHST11_ENST00000549260.1_Missense_Mutation_p.D280G	NM_018413.5	NP_060883.1	Q9NPF2	CHSTB_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 11	285					chondroitin sulfate biosynthetic process	Golgi membrane|integral to membrane	chondroitin 4-sulfotransferase activity|N-acetylgalactosamine 4-O-sulfotransferase activity			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|skin(1)	18						CTGGAAGAGGATTCTAATTAC	0.512000													6	47					0	0	1	0	0
PCMTD1	115294	broad.mit.edu	37	8	52773540	52773540	+	Missense_Mutation	SNP	G	G	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr8:52773540G>A	ENST00000360540.5	-	3	578	c.172C>T	c.(172-174)Cat>Tat	p.H58Y	PCMTD1_ENST00000522514.1_Missense_Mutation_p.H58Y|PCMTD1_ENST00000521344.1_Missense_Mutation_p.H58Y|PCMTD1_ENST00000519559.1_Intron|PCMTD1_ENST00000544451.1_Intron	NM_052937.2	NP_443169.2	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	58						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity			NS(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(17)|prostate(2)|skin(8)|soft_tissue(1)	37		Lung NSC(129;0.0795)|all_lung(136;0.144)				ATGTTTCCATGCTTCCAGGCT	0.428000													9	132					0	0	1	0	0
SH2D3C	10044	broad.mit.edu	37	9	130501170	130501170	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr9:130501170A>T	ENST00000314830.8	-	12	2551	c.2438T>A	c.(2437-2439)gTg>gAg	p.V813E	SH2D3C_ENST00000429553.1_Missense_Mutation_p.V459E|SH2D3C_ENST00000373274.3_Missense_Mutation_p.V653E|SH2D3C_ENST00000373277.4_Missense_Mutation_p.V656E|SH2D3C_ENST00000420366.1_Missense_Mutation_p.V655E|SH2D3C_ENST00000373276.3_Missense_Mutation_p.V745E	NM_170600.2	NP_733745.1	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C	813	Ras-GEF.				JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						CGTGCTGAACACCTCCAGGAG	0.637000													3	5					0	0	1	0	0
SYNDIG1L	646658	broad.mit.edu	37	14	74874277	74874277	+	Silent	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr14:74874277C>T	ENST00000331628.3	-	4	925	c.678G>A	c.(676-678)gtG>gtA	p.V226V	SYNDIG1L_ENST00000554823.1_Silent_p.V226V	NM_001105579.1	NP_001099049.1	A6NDD5	SYN1L_HUMAN	synapse differentiation inducing 1-like	226					response to biotic stimulus	Golgi apparatus|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|lung(8)|pancreas(1)|prostate(1)|skin(1)	14						CTGCCAGAGCCACCACCACAG	0.657000													27	73					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156921695	156921695	+	Splice_Site	SNP	C	C	G			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr5:156921695C>G	ENST00000257527.4	-	15	1781	c.1703_splice	c.e15+1	p.R568_splice	ADAM19_ENST00000430702.2_Splice_Site_p.R301_splice|ADAM19_ENST00000394020.1_Splice_Site_p.R570_splice|ADAM19_ENST00000517905.1_Splice_Site_p.R568_splice	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	568	Cys-rich.				proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGGTCATCACCTCATGTTGCA	0.527000													14	81					0	0	1	0	0
UGT2B4	7363	broad.mit.edu	37	4	70361502	70361502	+	Silent	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr4:70361502C>A	ENST00000305107.6	-	1	124	c.78G>T	c.(76-78)gtG>gtT	p.V26V	UGT2B4_ENST00000506580.1_5'UTR|UGT2B4_ENST00000512583.1_Silent_p.V26V|UGT2B4_ENST00000381096.3_Intron	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	26					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						GCCACACCAGCACCTTTCCAC	0.458000													9	217					0.000274275	0.000299843	1	1	0
LRRC36	55282	broad.mit.edu	37	16	67375936	67375936	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr16:67375936T>A	ENST00000329956.6	+	2	166	c.147T>A	c.(145-147)ttT>ttA	p.F49L	LRRC36_ENST00000563303.1_Intron	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	49										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		TCAGAAATTTTAAAAATCTCC	0.363000													8	48					0	0	1	0	0
DST	667	broad.mit.edu	37	6	56480547	56480547	+	Missense_Mutation	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr6:56480547C>T	ENST00000370765.6	-	24	7825	c.7718G>A	c.(7717-7719)cGg>cAg	p.R2573Q	DST_ENST00000370788.2_Intron|DST_ENST00000361203.3_Intron|DST_ENST00000370754.5_Intron|DST_ENST00000370769.4_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000244364.6_Intron|DST_ENST00000446842.2_Intron|DST_ENST00000312431.6_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	1869					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TATTGATAACCGAGAGTGAAC	0.378000													28	127					0	0	1	0	0
UIMC1	51720	broad.mit.edu	37	5	176338362	176338362	+	Silent	SNP	C	C	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr5:176338362C>T	ENST00000377219.2	-	11	1795	c.1629G>A	c.(1627-1629)aaG>aaA	p.K543K	UIMC1_ENST00000511320.1_Silent_p.K542K|UIMC1_ENST00000506128.1_Silent_p.K376K|UIMC1_ENST00000503273.1_5'UTR|UIMC1_ENST00000377227.4_Silent_p.K542K	NM_016290.4	NP_057374.3	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	542	Zinc-finger-like region.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			NS(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(5)|ovary(4)|pancreas(1)|prostate(1)|skin(1)	21	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACTCTTGGTCTTGGCCTCTT	0.373000													17	78					0	0	1	0	0
C19orf54	284325	broad.mit.edu	37	19	41250511	41250511	+	Missense_Mutation	SNP	C	C	G			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr19:41250511C>G	ENST00000378313.2	-	3	589	c.470G>C	c.(469-471)cGg>cCg	p.R157P	C19orf54_ENST00000470681.1_Missense_Mutation_p.R19P|C19orf54_ENST00000598485.2_Silent_p.T26T|C19orf54_ENST00000598729.1_Silent_p.T26T|C19orf54_ENST00000339153.3_Silent_p.T26T	NM_198476.3	NP_940878.3	Q5BKX5	CS054_HUMAN	chromosome 19 open reading frame 54	157										breast(1)|lung(1)|urinary_tract(2)	4			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)			CGTGGCCACCCGTATGAGTCT	0.627000													8	45					0	0	1	0	0
HAO1	54363	broad.mit.edu	37	20	7875872	7875872	+	Splice_Site	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr20:7875872C>A	ENST00000378789.3	-	5	773		c.e5-1			NM_017545.2	NP_060015.1	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase (glycolate oxidase) 1						cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						GCATCATCACCTGGAGAGAGT	0.507000													25	94					4.87955e-14	6.4893e-14	1	1	0
TRBV6-7	28600	broad.mit.edu	37	7	142143882	142143882	+	RNA	SNP	C	C	G			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr7:142143882C>G	ENST00000390373.2	-	0	113																											ACAGCAGAGTCATGCTCTGTC	0.507000													7	126					0	0	1	0	0
BICD1	636	broad.mit.edu	37	12	32491827	32491827	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr12:32491827T>A	ENST00000281474.5	+	8	2781	c.2678T>A	c.(2677-2679)tTt>tAt	p.F893Y	BICD1_ENST00000548411.1_Intron	NM_001714.2	NP_001705.2	Q96G01	BICD1_HUMAN	bicaudal D homolog 1 (Drosophila)	893					anatomical structure morphogenesis|intracellular mRNA localization|microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule|positive regulation of receptor-mediated endocytosis|protein localization to organelle|RNA processing|stress granule assembly|viral reproduction	cytoplasmic vesicle|cytoskeleton|cytosol|host cell viral assembly compartment|membrane|perinuclear region of cytoplasm|trans-Golgi network	cytoskeletal adaptor activity|dynactin binding|dynein binding|proteinase activated receptor binding|Rab GTPase binding|structural constituent of cytoskeleton			NS(1)|breast(2)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	46	all_cancers(9;5.13e-11)|all_epithelial(9;2.71e-11)|all_lung(12;6.66e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0213)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0201)			ACAGAATCATTTCTTCTGAAG	0.498000													16	136					0	0	1	0	0
GP2	2813	broad.mit.edu	37	16	20335522	20335522	+	Missense_Mutation	SNP	G	G	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr16:20335522G>T	ENST00000302555.5	-	3	300	c.151C>A	c.(151-153)Cct>Act	p.P51T	GP2_ENST00000381360.5_Intron|GP2_ENST00000381362.4_Missense_Mutation_p.P51T|GP2_ENST00000341642.5_Intron			P55259	GP2_HUMAN	glycoprotein 2 (zymogen granule membrane)	51						anchored to membrane|extracellular region|plasma membrane		p.P51A(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						GGGGTGCCAGGAGCTCCGCAG	0.552000													12	68					5.50884e-06	6.17948e-06	1	1	0
ZNF728	388523	broad.mit.edu	37	19	23159797	23159797	+	Missense_Mutation	SNP	T	T	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr19:23159797T>A	ENST00000594710.1	-	4	487	c.342A>T	c.(340-342)aaA>aaT	p.K114N		NM_001267716.1	NP_001254645.1			zinc finger protein 728																		TACAACCAATTTTTAACTGTA	0.358000													4	82					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133899345	133899345	+	Missense_Mutation	SNP	A	A	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr8:133899345A>T	ENST00000220616.4	+	9	1768	c.1728A>T	c.(1726-1728)gaA>gaT	p.E576D	TG_ENST00000377869.1_Missense_Mutation_p.E576D	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	576					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGCTTCCAGAATTCCTTCTCT	0.458000													22	172					0	0	1	0	0
MCF2L	23263	broad.mit.edu	37	13	113719372	113719372	+	Silent	SNP	G	G	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr13:113719372G>T	ENST00000397030.1	+	7	865	c.828G>T	c.(826-828)gcG>gcT	p.A276A	MCF2L_ENST00000375601.3_Silent_p.A247A|MCF2L_ENST00000421756.1_Silent_p.A247A|MCF2L_ENST00000375597.4_Silent_p.A241A|MCF2L_ENST00000423482.2_Silent_p.A241A|MCF2L_ENST00000375604.2_Silent_p.A300A|MCF2L_ENST00000535094.2_Silent_p.A243A|MCF2L_ENST00000442652.2_Silent_p.A273A|MCF2L_ENST00000434480.2_Silent_p.A249A|MCF2L_ENST00000375608.3_Silent_p.A273A			O15068	MCF2L_HUMAN	MCF.2 cell line derived transforming sequence-like	273					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	Rho guanyl-nucleotide exchange factor activity			kidney(1)|large_intestine(5)|ovary(1)|stomach(1)	8	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)	all_cancers(25;0.118)|all_lung(25;0.0368)|all_epithelial(44;0.0396)|Lung NSC(25;0.129)|Breast(118;0.188)				TGCTGTGTGCGCACACAGAGA	0.627000													15	53					2.23348e-06	2.54973e-06	1	1	0
SOX5	6660	broad.mit.edu	37	12	23687282	23687282	+	Silent	SNP	A	A	G			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr12:23687282A>G	ENST00000546136.1	-	14	2126	c.2124T>C	c.(2122-2124)caT>caC	p.H708H	SOX5_ENST00000537393.1_Silent_p.H686H|SOX5_ENST00000381381.2_Silent_p.H600H|SOX5_ENST00000541536.1_Silent_p.H600H|SOX5_ENST00000545921.1_Silent_p.H711H|SOX5_ENST00000396007.2_Silent_p.H335H|SOX5_ENST00000309359.1_Silent_p.H708H|SOX5_ENST00000451604.2_Silent_p.H721H			P35711	SOX5_HUMAN	SRY (sex determining region Y)-box 5	721					transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(25)|ovary(5)|skin(2)|upper_aerodigestive_tract(3)	57						CTTCTTTGATATGTGGCTCCT	0.512000													27	124					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61829653	61829653	+	Silent	SNP	T	T	C			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr10:61829653T>C	ENST00000280772.1	-	37	11177	c.10986A>G	c.(10984-10986)tcA>tcG	p.S3662S	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3662					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGGTGTCCCCTGACTGTGGCT	0.517000													12	63					0	0	1	0	0
C20orf26	26074	broad.mit.edu	37	20	20243672	20243672	+	Silent	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr20:20243672C>A	ENST00000245957.5	+	21	2477	c.2401C>A	c.(2401-2403)Cgg>Agg	p.R801R	C20orf26_ENST00000389656.3_Silent_p.R157R|RP5-1096J16.1_ENST00000460400.1_RNA|C20orf26_ENST00000377309.2_Silent_p.R157R|C20orf26_ENST00000377293.1_Silent_p.R157R	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	801										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		CAGTCAGCGGCGGTACACGGG	0.468000													21	80					7.45023e-12	9.51563e-12	1	1	0
JOSD2	126119	broad.mit.edu	37	19	51010941	51010941	+	Silent	SNP	G	G	T			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr19:51010941G>T	ENST00000598418.1	-	3	415	c.162C>A	c.(160-162)tcC>tcA	p.S54S	JOSD2_ENST00000391815.3_Silent_p.S54S|JOSD2_ENST00000595669.1_Intron|JOSD2_ENST00000601423.1_Silent_p.S54S	NM_001270639.1|NM_001270640.1	NP_001257568.1|NP_001257569.1	Q8TAC2	JOS2_HUMAN	Josephin domain containing 2	54	Josephin.				protein deubiquitination		ubiquitin-specific protease activity			kidney(1)|lung(3)|prostate(1)	5		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00743)|GBM - Glioblastoma multiforme(134;0.0364)		GGTTCAGCCGGGAGTCTGGGG	0.662000													23	69					1.10923e-09	1.40285e-09	1	1	0
ZNF99	7652	broad.mit.edu	37	19	22940042	22940042	+	Silent	SNP	T	T	C	rs62119154		TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr19:22940042T>C	ENST00000397104.3	-	6	2288	c.2289A>G	c.(2287-2289)aaA>aaG	p.K763K						zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TTATCTTATGTTTCCTAAGGG	0.358000													37	85					0	0	1	0	0
CNOT6L	246175	broad.mit.edu	37	4	78652634	78652634	+	Missense_Mutation	SNP	C	C	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr4:78652634C>A	ENST00000504123.1	-	9	1061	c.931G>T	c.(931-933)Gat>Tat	p.D311Y	CNOT6L_ENST00000264903.4_Missense_Mutation_p.D311Y			Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	311					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			kidney(1)|large_intestine(1)|lung(6)|urinary_tract(1)	9						TCGGATCCATCTGAATTAGCC	0.393000													10	34					0.00621372	0.00646427	1	1	0
PACS2	23241	broad.mit.edu	37	14	105849203	105849203	+	Silent	SNP	G	G	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr14:105849203G>A	ENST00000447393.1	+	15	1753	c.1578G>A	c.(1576-1578)gcG>gcA	p.A526A	PACS2_ENST00000547217.1_Silent_p.A492A|PACS2_ENST00000458164.2_Silent_p.A526A|PACS2_ENST00000325438.8_Silent_p.A522A|PACS2_ENST00000430725.2_Silent_p.A447A	NM_015197.3	NP_056012.2	Q86VP3	PACS2_HUMAN	phosphofurin acidic cluster sorting protein 2	522					apoptosis|interspecies interaction between organisms	endoplasmic reticulum lumen|mitochondrion				endometrium(2)|kidney(2)|lung(7)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|urinary_tract(1)	21		all_cancers(154;0.0351)|all_epithelial(191;0.153)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.0145)|Epithelial(46;0.036)	Epithelial(152;0.138)		GCTCTCCTGCGGACGTCCAGG	0.637000													4	39					0	0	1	0	0
ANKS3	124401	broad.mit.edu	37	16	4751474	4751474	+	Silent	SNP	G	G	A			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr16:4751474G>A	ENST00000304283.4	-	10	1374	c.1080C>T	c.(1078-1080)gcC>gcT	p.A360A	ANKS3_ENST00000446014.2_Silent_p.A231A|ANKS3_ENST00000585773.1_Silent_p.A287A|ANKS3_ENST00000450067.2_Silent_p.A154A	NM_133450.3	NP_597707.1	Q6ZW76	ANKS3_HUMAN	ankyrin repeat and sterile alpha motif domain containing 3	360	Ser-rich.									endometrium(5)|kidney(4)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	19						TGAGCCCCTGGGCTCTGGCCA	0.632000													3	26					0	0	1	0	0
PPM1B	5495	broad.mit.edu	37	2	44428719	44428719	+	Missense_Mutation	SNP	G	G	C			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr2:44428719G>C	ENST00000378551.2	+	2	793	c.381G>C	c.(379-381)atG>atC	p.M127I	PPM1B_ENST00000345249.4_Intron|PPM1B_ENST00000282412.4_Missense_Mutation_p.M127I|PPM1B_ENST00000409895.4_Missense_Mutation_p.M127I|PPM1B_ENST00000409432.3_Missense_Mutation_p.M127I|PPM1B_ENST00000378540.4_3'UTR	NM_177968.2	NP_808907.1	O75688	PPM1B_HUMAN	protein phosphatase, Mg2+/Mn2+ dependent, 1B	127					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(4)|large_intestine(3)|lung(7)|skin(2)	16		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				GAAACGGGATGGACAGGAGTG	0.398000													16	137					0	0	1	0	0
AC027612.3	0	broad.mit.edu	37	2	91899626	91899626	+	RNA	DEL	A	A	-			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr2:91899626delA	ENST00000436174.1	-	0	168																											CCAGAGGCTCAAAAAAAAAAA	0.289													13	16	---	---	---	---					
LRRN3	54674	broad.mit.edu	37	7	110763695	110763695	+	Frame_Shift_Del	DEL	G	G	-	rs150310313		TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr7:110763695delG	ENST00000451085.1	+	4	1913	c.867delG	c.(865-867)ttfs	p.L289fs	IMMP2L_ENST00000447215.1_Intron|IMMP2L_ENST00000450877.1_Intron|IMMP2L_ENST00000489381.1_Intron|IMMP2L_ENST00000331762.3_Intron|LRRN3_ENST00000308478.5_Frame_Shift_Del_p.L289fs|IMMP2L_ENST00000437687.1_Intron|IMMP2L_ENST00000415362.1_Intron|IMMP2L_ENST00000405709.2_Intron|LRRN3_ENST00000422987.3_Frame_Shift_Del_p.L289fs|IMMP2L_ENST00000452895.1_Intron	NM_001099660.1	NP_001093130.1	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3	289						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(15)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		TAAAAGAGTTGGGGATAAATA	0.323													30	127	---	---	---	---					
PLAG1	5324	broad.mit.edu	37	8	57079623	57079623	+	Frame_Shift_Del	DEL	G	G	-			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr8:57079623delG	ENST00000316981.3	-	5	1161	c.682delC	c.(682-684)tgfs	p.L228fs	PLAG1_ENST00000429357.2_Frame_Shift_Del_p.L228fs|PLAG1_ENST00000423799.2_Frame_Shift_Del_p.L146fs	NM_001114634.1|NM_002655.2	NP_001108106.1|NP_002646.2	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1	228	Decreased nuclear import with localization in the nucleus but also in the cytoplasm.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|FGFR1_ENST00000447712/PLAG1(28)|COL1A2/PLAG1(3)|CHCHD7/PLAG1(12)|TCEA1_ENST00000521604/PLAG1(3)	breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(7)|lung(11)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			TGTCGAGTCAGGTGATCCTTT	0.478			T	"""TCEA1, LIFR, CTNNB1, CHCHD7"""	salivary adenoma								26	196	---	---	---	---					
LRRC37A6P	387646	broad.mit.edu	37	10	27539714	27539714	+	RNA	DEL	A	A	-			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr10:27539714delA	ENST00000574842.1	+	0	983																											CTGGAGGTTGAACTGTCACCT	0.493													61	231	---	---	---	---					
MYBPC3	4607	broad.mit.edu	37	11	47364158	47364158	+	Frame_Shift_Del	DEL	C	C	-			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr11:47364158delC	ENST00000545968.1	-	17	1649	c.1595delG	c.(1594-1596)gcfs	p.G532fs	MYBPC3_ENST00000399249.2_Frame_Shift_Del_p.G532fs|MYBPC3_ENST00000256993.4_Frame_Shift_Del_p.G531fs	NM_000256.3	NP_000247.2	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	531	Ig-like C2-type 3.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		CAGCGCCTGGCCCCCGCTAGT	0.632													7	29	---	---	---	---					
KMT2D	8085	broad.mit.edu	37	12	49415856	49415858	+	In_Frame_Del	DEL	GAT	GAT	-			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr12:49415856_49415858delGAT	ENST00000301067.7	-	53	16488_16490	c.16489_16491delATC	c.(16489-16491)del	p.I5497del		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		GCCGGCTGGAGATGATGATGATT	0.527													51	234	---	---	---	---					
CSPG4P5	114817	broad.mit.edu	37	15	84958415	84958426	+	RNA	DEL	CGAGGACATTGG	CGAGGACATTGG	-			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr15:84958415_84958426delCGAGGACATTGG	ENST00000558801.1	-	0	6303_6314																											TCGGGCACCACGAGGACATTGGTGAGGACAGG	0.557													3	6	---	---	---	---					
AC015922.5	0	broad.mit.edu	37	17	15737072	15737073	+	RNA	INS	-	-	TTTA	rs71838018		TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr17:15737072_15737073insTTTA	ENST00000584636.1	+	0	316																											CTCTATCCTGCTTTATCTTGGA	0.460													2	4	---	---	---	---					
RAI1	10743	broad.mit.edu	37	17	17699359	17699359	+	Frame_Shift_Del	DEL	C	C	-			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr17:17699359delC	ENST00000353383.1	+	3	3566	c.3097delC	c.(3097-3099)ccfs	p.P1034fs	RAI1_ENST00000261641.6_Frame_Shift_Del_p.P1034fs	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1034						cytoplasm|nucleus	zinc ion binding	p.Q1035fs*31(1)		breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		CTGCACAGGGCCCCCCCAGGG	0.697													2	4	---	---	---	---					
CDC27	996	broad.mit.edu	37	17	45219612	45219612	+	Frame_Shift_Del	DEL	A	A	-			TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr17:45219612delA	ENST00000066544.3	-	11	1454	c.1361delT	c.(1360-1362)cafs	p.L454fs	CDC27_ENST00000531206.1_Frame_Shift_Del_p.L460fs|CDC27_ENST00000527547.1_Frame_Shift_Del_p.L454fs|CDC27_ENST00000446365.2_Frame_Shift_Del_p.L393fs	NM_001114091.1|NM_001256.3	NP_001107563.1|NP_001247.3	P30260	CDC27_HUMAN	cell division cycle 27	454					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding			NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						TGCTTTTTGTAGATTAAAGGC	0.308													9	55	---	---	---	---					
STK11	6794	broad.mit.edu	37	19	1207077	1207077	+	Frame_Shift_Del	DEL	G	G	-	rs121913319		TCGA-MP-A4TD-01A-32D-A25L-08	TCGA-MP-A4TD-10A-01D-A25L-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	C440708B-9C8B-4D43-9DC4-5066D6BA5209	A899CB98-F9C5-41F5-B371-D8936935789F	g.chr19:1207077delG	ENST00000326873.7	+	1	1338	c.165delG	c.(163-165)ctfs	p.L55fs	STK11_ENST00000585748.1_Intron	NM_000455.4	NP_000446.1	Q15831	STK11_HUMAN	serine/threonine kinase 11	55	Protein kinase.				anoikis|cell cycle arrest|energy reserve metabolic process|insulin receptor signaling pathway|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.0?(20)|p.E57fs*7(4)|p.?(3)|p.G56fs*107(1)		biliary_tract(1)|breast(3)|cervix(35)|gastrointestinal_tract_(site_indeterminate)(5)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(14)|liver(1)|lung(219)|oesophagus(1)|ovary(4)|pancreas(6)|prostate(2)|skin(15)|small_intestine(1)|stomach(9)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	328		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Renal(1328;0.0183)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|Lung(535;0.00942)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGACCTGCTGGGGGAAGGCT	0.607	E57fs*7(NCIH1395_LUNG)	14	"""D, Mis, N, F, S"""		"""NSCLC, pancreatic"""	"""jejunal harmartoma, ovarian, testicular, pancreatic"""			Peutz-Jeghers syndrome	TSP Lung(3;<1E-08)			19	35	---	---	---	---					
