Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
IKZF5	64376	broad.mit.edu	37	10	124753954	124753954	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:124753954G>A	ENST00000368886.5	-	5	922	c.602C>T	c.(601-603)cCa>cTa	p.P201L	PSTK_ENST00000497219.1_Intron	NM_001271840.1	NP_001258769.1	Q9H5V7	IKZF5_HUMAN	IKAROS family zinc finger 5 (Pegasus)	201					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|lung(3)|prostate(1)	6		all_neural(114;0.169)|Colorectal(57;0.178)|Glioma(114;0.222)		Colorectal(40;0.0701)|COAD - Colon adenocarcinoma(40;0.0754)		CATGGAAGGTGGACTTAAGTT	0.423000													72	113					0	0	0.000147903	0	0
TM7SF2	7108	broad.mit.edu	37	11	64883442	64883442	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:64883442C>T	ENST00000279263.7	+	10	1336	c.1174C>T	c.(1174-1176)Cgg>Tgg	p.R392W	TM7SF2_ENST00000540748.1_Missense_Mutation_p.R276W|TM7SF2_ENST00000345348.5_Missense_Mutation_p.R365W	NM_003273.2	NP_003264.2	O76062	ERG24_HUMAN	transmembrane 7 superfamily member 2	392					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane	delta14-sterol reductase activity			lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						CCGGGATGAGCGGCAGTGCCT	0.627000													10	17					0	0	3.86212e-05	0	0
KEL	3792	broad.mit.edu	37	7	142640645	142640645	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:142640645G>A	ENST00000355265.2	-	15	2105	c.1631C>T	c.(1630-1632)tCg>tTg	p.S544L		NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	544					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					GTCAGATACCGAATAGTAAGC	0.557000													8	96					0	0	3.86212e-05	0	0
BDP1	55814	broad.mit.edu	37	5	70793195	70793195	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr5:70793195C>T	ENST00000358731.4	+	13	2161	c.1898C>T	c.(1897-1899)tCa>tTa	p.S633L	BDP1_ENST00000380675.2_5'UTR	NM_018429.2	NP_060899.2	A6H8Y1	BDP1_HUMAN	B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB	633					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			NS(2)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(34)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		Lung NSC(167;0.000422)|Prostate(74;0.00815)|Ovarian(174;0.0176)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;5.28e-56)|Epithelial(20;2.31e-50)		TCAGTTCTTTCACAAGGCAAA	0.353000													24	38					0	0	0.000147802	0	0
NLRP7	199713	broad.mit.edu	37	19	55450542	55450542	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:55450542C>T	ENST00000446217.1	-	6	2131	c.1729G>A	c.(1729-1731)Gaa>Aaa	p.E577K	NLRP7_ENST00000340844.2_Missense_Mutation_p.E549K|NLRP7_ENST00000588756.1_Missense_Mutation_p.E549K|NLRP7_ENST00000328092.5_Missense_Mutation_p.E549K|NLRP7_ENST00000592784.1_Missense_Mutation_p.E549K|NLRP7_ENST00000590030.1_Missense_Mutation_p.E549K|NLRP7_ENST00000448121.2_Missense_Mutation_p.E549K			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	549							ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		TGCAGCAATTCCTGTTTGATG	0.512000													14	59					0	0	0.000308642	0	0
PLIN4	729359	broad.mit.edu	37	19	4511995	4511995	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:4511995G>A	ENST00000301286.3	-	3	1934	c.1935C>T	c.(1933-1935)atC>atT	p.I645I		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	645	27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						TACCTGTCGCGATATTTTGGG	0.572000													35	62					0	0	7.24521e-05	0	0
CLUH	23277	broad.mit.edu	37	17	2603696	2603696	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:2603696G>A	ENST00000570628.1	-	9	1237	c.1132C>T	c.(1132-1134)Cga>Tga	p.R378*	CLUH_ENST00000538975.1_Nonsense_Mutation_p.R378*|CLUH_ENST00000435359.1_Nonsense_Mutation_p.R378*|CLUH_ENST00000575014.1_Nonsense_Mutation_p.R310*					clustered mitochondria (cluA/CLU1) homolog																		GCCCTTTCTCGGAGCAGCCGC	0.602000													5	25					0	0	1.23904e-05	0	0
RIN3	79890	broad.mit.edu	37	14	93151488	93151488	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:93151488C>T	ENST00000216487.7	+	9	2783	c.2624C>T	c.(2623-2625)tCc>tTc	p.S875F	RIN3_ENST00000418924.2_3'UTR	NM_024832.3	NP_079108.3	Q8TB24	RIN3_HUMAN	Ras and Rab interactor 3	875					endocytosis|signal transduction	cytoplasmic membrane-bounded vesicle|early endosome	GTPase activator activity|Ras GTPase binding	p.S875F(1)		endometrium(4)|kidney(2)|large_intestine(7)|lung(19)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36		all_cancers(154;0.0701)				TCCCGCTCCTCCGTACAGGTG	0.672000													4	12					0	0	0.00024832	0	0
AMY2B	280	broad.mit.edu	37	1	104114369	104114369	+	Missense_Mutation	SNP	C	C	T	rs141409903		TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:104114369C>T	ENST00000361355.4	+	3	761	c.145C>T	c.(145-147)Ccc>Tcc	p.P49S	AMY2B_ENST00000491397.1_3'UTR	NM_020978.3	NP_066188.1	P19961	AMY2B_HUMAN	amylase, alpha 2B (pancreatic)	49					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding			breast(1)|endometrium(7)|kidney(4)|large_intestine(1)|lung(30)|prostate(1)|skin(1)|urinary_tract(1)	46		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		ATATTTAGCTCCCAAGGGATT	0.403000													14	107					0	0	9.22233e-05	0	0
SNTG2	54221	broad.mit.edu	37	2	1161240	1161240	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:1161240C>T	ENST00000308624.5	+	7	547	c.418C>T	c.(418-420)Ctg>Ttg	p.L140L	SNTG2_ENST00000407292.1_Intron|SNTG2_ENST00000467759.1_3'UTR	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	140	PDZ.				central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		ACAGGTGCATCTGCTGAGAAA	0.433000													37	83					0	0	0.000374591	0	0
KIAA0226L	80183	broad.mit.edu	37	13	46917568	46917568	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr13:46917568G>A	ENST00000378797.2	-	14	2391	c.1787C>T	c.(1786-1788)tCa>tTa	p.S596L	KIAA0226L_ENST00000378787.3_Missense_Mutation_p.S596L|KIAA0226L_ENST00000378784.4_Silent_p.I580I|KIAA0226L_ENST00000429979.1_Silent_p.I647I|KIAA0226L_ENST00000322896.6_Silent_p.I490I|KIAA0226L_ENST00000378781.3_3'UTR|KIAA0226L_ENST00000389908.3_Silent_p.I647I|KIAA0226L_ENST00000409879.2_Silent_p.I490I|KIAA0226L_ENST00000534925.1_Silent_p.I512I			Q9H714	CM018_HUMAN	KIAA0226-like	0										NS(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(7)|pancreas(1)	26						TCCTCGCTGTGATCCTCGCAC	0.527000													6	27					0	0	8.12818e-05	0	0
DSC3	1825	broad.mit.edu	37	18	28605779	28605779	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr18:28605779C>T	ENST00000434452.1	-	5	731	c.577G>A	c.(577-579)Gga>Aga	p.G193R	DSC3_ENST00000360428.4_Missense_Mutation_p.G193R	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	193	Cadherin 1.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			AATAGATTTCCAGTGTCTCTT	0.333000													7	23					0	0	8.12818e-05	0	0
ZNF783	100289678	broad.mit.edu	37	7	148978696	148978696	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:148978696C>T	ENST00000434415.1	+	6	1066	c.903C>T	c.(901-903)atC>atT	p.I301I	ZNF783_ENST00000489518.1_Intron	NM_001195220.1	NP_001182149.1	C9J9J2	C9J9J2_HUMAN	zinc finger family member 783	301					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)	22	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.0014)			AGTGTAGAATCCCCCGAGGGC	0.687000													14	57					0	0	0.000151284	0	0
TBC1D32	221322	broad.mit.edu	37	6	121481215	121481215	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:121481215G>A	ENST00000275159.6	-	25	2836	c.2837C>T	c.(2836-2838)tCa>tTa	p.S946L	TBC1D32_ENST00000398212.2_Missense_Mutation_p.S905L|TBC1D32_ENST00000398197.2_5'UTR					TBC1 domain family, member 32									p.S905L(1)									CAATGGATATGATGAAAACAT	0.303000													25	101					0	0	0.000147802	0	0
KCNQ5	56479	broad.mit.edu	37	6	73905049	73905049	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:73905049G>A	ENST00000342056.2	+	15	3166	c.2768G>A	c.(2767-2769)aGg>aAg	p.R923K	KCNQ5_ENST00000355194.4_Missense_Mutation_p.R904K|KCNQ5_ENST00000403813.2_Missense_Mutation_p.R895K|KCNQ5_ENST00000355635.3_Missense_Mutation_p.R905K|KCNQ5_ENST00000414165.2_Missense_Mutation_p.R794K|KCNQ5_ENST00000402622.2_Missense_Mutation_p.R914K|KCNQ5_ENST00000370398.1_Missense_Mutation_p.R904K	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	904					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GACTCTCTAAGGACTGGAAGG	0.483000													29	33					0	0	0.000279167	0	0
SNHG14	104472715	broad.mit.edu	37	15	25342814	25342814	+	RNA	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr15:25342814C>T	ENST00000546682.1	+	0	1229				SNHG14_ENST00000553108.1_RNA|SNHG14_ENST00000549804.2_RNA|SNORD116-25_ENST00000516517.1_RNA	NR_003361.1																						GTGCCTGGATCGATGATGACT	0.478000													6	23					0	0	8.12818e-05	0	0
HDAC5	10014	broad.mit.edu	37	17	42156583	42156583	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:42156583C>T	ENST00000225983.6	-	24	3333	c.3010G>A	c.(3010-3012)Gag>Aag	p.E1004K	HDAC5_ENST00000393622.2_Missense_Mutation_p.E1003K|HDAC5_ENST00000336057.5_Missense_Mutation_p.E918K|HDAC5_ENST00000586802.1_Missense_Mutation_p.E1003K			Q9UQL6	HDAC5_HUMAN	histone deacetylase 5	1003	Histone deacetylase.				B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	21		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		TGGCCTCCCTCCAGGGCCAGC	0.607000													29	26					0	0	0.000117367	0	0
NLRP11	204801	broad.mit.edu	37	19	56321664	56321664	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:56321664G>A	ENST00000443188.1	-	5	1022	c.312C>T	c.(310-312)ttC>ttT	p.F104F	NLRP11_ENST00000589093.1_Silent_p.F104F|NLRP11_ENST00000360133.3_Silent_p.F104F|NLRP11_ENST00000592953.1_Silent_p.F5F|NLRP11_ENST00000589824.2_Silent_p.F104F	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	104							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		ATTGCAGCATGAATTTTCTCC	0.368000													6	20					0	0	8.12818e-05	0	0
SPOP	8405	broad.mit.edu	37	17	47684678	47684678	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:47684678G>A	ENST00000393331.3	-	10	1241	c.771C>T	c.(769-771)ttC>ttT	p.F257F	SPOP_ENST00000393328.2_Silent_p.F257F|SPOP_ENST00000504102.1_Silent_p.F257F|SPOP_ENST00000347630.2_Silent_p.F257F|SPOP_ENST00000503676.1_Silent_p.F257F	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	257	BTB.				mRNA processing	nucleus	protein binding			endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						CCGTGTAAATGAAGCACATCA	0.393000										Prostate(2;0.17)			18	20					0	0	0.000132079	0	0
NXF3	56000	broad.mit.edu	37	X	102338596	102338596	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:102338596C>T	ENST00000395065.3	-	4	477	c.376G>A	c.(376-378)Gag>Aag	p.E126K	NXF3_ENST00000425644.1_5'UTR|NXF3_ENST00000425463.2_Missense_Mutation_p.E37K	NM_022052.1	NP_071335.1	Q9H4D5	NXF3_HUMAN	nuclear RNA export factor 3	126	RRM.					cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(15)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26						AGCCACTTCTCATTGTATTTT	0.418000													43	73					0	0	8.96297e-05	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713603	70713603	+	RNA	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:70713603C>T	ENST00000530196.1	-	0	915					NR_003951.1																						TTCCAAATTTCAATTCCAATC	0.363000													20	48					0	0	9.7654e-05	0	0
DUSP9	1852	broad.mit.edu	37	X	152914836	152914836	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:152914836G>A	ENST00000342782.3	+	3	788	c.523G>A	c.(523-525)Gaa>Aaa	p.E175K	DUSP9_ENST00000370167.4_Missense_Mutation_p.E175K			Q99956	DUS9_HUMAN	dual specificity phosphatase 9	175					inactivation of MAPK activity|JNK cascade	cytosol|endoplasmic reticulum|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)	16	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTCTGATGCGGAATCCGAGGC	0.692000													10	49					0	0	0.00010058	0	0
RADIL	55698	broad.mit.edu	37	7	4841435	4841435	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:4841435C>T	ENST00000399583.3	-	12	2878	c.2691G>A	c.(2689-2691)acG>acA	p.T897T	RADIL_ENST00000536091.1_3'UTR|RADIL_ENST00000538469.1_Silent_p.T657T	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	897	Pro-rich.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		AGGACGAGTCCGTGTGCGGGG	0.721000													10	17					0	0	0.000219431	0	0
OBSCN	84033	broad.mit.edu	37	1	228487200	228487200	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:228487200C>T	ENST00000570156.2	+	50	13525	c.13451C>T	c.(13450-13452)aCc>aTc	p.T4484I	RP5-1139B12.4_ENST00000602778.1_RNA|OBSCN_ENST00000284548.11_Intron|OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000366707.4_Missense_Mutation_p.T1174I|OBSCN_ENST00000366709.4_Intron|OBSCN_ENST00000359599.6_3'UTR	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3527	Ig-like 46.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CAGGAGAGGACCTCAGCTACA	0.542000													39	87					0	0	8.96297e-05	0	0
HECTD4	283450	broad.mit.edu	37	12	112672931	112672931	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:112672931G>A	ENST00000550722.1	-	37	5822	c.5427C>T	c.(5425-5427)atC>atT	p.I1809I	HECTD4_ENST00000430131.2_Silent_p.I1533I|HECTD4_ENST00000377560.5_Silent_p.I1783I	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		CCCGCTTGTGGATAAATATCG	0.468000													3	8					0	0	6.4e-05	0	0
PLXNC1	10154	broad.mit.edu	37	12	94673381	94673381	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:94673381A>G	ENST00000258526.4	+	22	3980	c.3731A>G	c.(3730-3732)aAa>aGa	p.K1244R	RP11-1105G2.3_ENST00000551941.1_Intron|PLXNC1_ENST00000545312.1_5'UTR|PLXNC1_ENST00000547057.1_Missense_Mutation_p.K291R	NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	1244					axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						TTCTTAAGCAAAAATGGCTCT	0.478000													17	84					0	0	0.000175454	0	0
TLR9	54106	broad.mit.edu	37	3	52255864	52255864	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:52255864A>G	ENST00000597542.1	-	9	3497	c.2540T>C	c.(2539-2541)cTg>cCg	p.L847P	TLR9_ENST00000360658.2_Missense_Mutation_p.L823P|TLR9_ENST00000494383.1_Silent_p.A976A			Q9NR96	TLR9_HUMAN	toll-like receptor 9	823					defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			endometrium(4)|large_intestine(11)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	CACAGCCAGCAGCGAGAGGGC	0.657000													9	13					0	0	2.17888e-05	0	0
TRAV12-2	28673	broad.mit.edu	37	14	22356678	22356678	+	RNA	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:22356678G>A	ENST00000390437.2	+	0	441																											TCTGTGCCGTGAACACACAGT	0.532000													48	108					0	0	0.000147903	0	0
MUC16	94025	broad.mit.edu	37	19	9072100	9072100	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:9072100C>T	ENST00000397910.4	-	3	15549	c.15346G>A	c.(15346-15348)Gaa>Aaa	p.E5116K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5118	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAAAAATTTCCTTTGTGTCT	0.443000													4	29					0	0	0.00024832	0	0
CHL1	10752	broad.mit.edu	37	3	407753	407753	+	Missense_Mutation	SNP	G	G	A	rs138000940	byFrequency	TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:407753G>A	ENST00000256509.2	+	15	2348	c.1706G>A	c.(1705-1707)aGt>aAt	p.S569N	CHL1_ENST00000397491.2_Missense_Mutation_p.S553N|CHL1-AS1_ENST00000417612.1_RNA	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	553	Ig-like C2-type 6.				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TTGTCCTGGAGTAAAGATGGA	0.368000													7	18					0	0	0.000274275	0	0
SHROOM2	357	broad.mit.edu	37	X	9863311	9863311	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:9863311G>A	ENST00000380913.3	+	4	1453	c.1363G>A	c.(1363-1365)Gac>Aac	p.D455N		NM_001649.2	NP_001640.1	Q13796	SHRM2_HUMAN	shroom family member 2	455					apical protein localization|brain development|cell migration|cell morphogenesis|cellular pigment accumulation|ear development|establishment of melanosome localization|eye pigment granule organization|lens morphogenesis in camera-type eye|melanosome organization	apical plasma membrane|cell-cell adherens junction|microtubule|tight junction	actin filament binding|beta-catenin binding|ligand-gated sodium channel activity			breast(4)|central_nervous_system(2)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(13)|ovary(3)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	57		Hepatocellular(5;0.000888)				CTTCCAGAACGACAGCCCTCC	0.672000													14	52					0	0	0.000151284	0	0
FAM71B	153745	broad.mit.edu	37	5	156589596	156589596	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr5:156589596G>A	ENST00000302938.4	-	2	1775	c.1680C>T	c.(1678-1680)atC>atT	p.I560I		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	560						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TCTTAGCCACGATATCTACCT	0.483000													122	150					0	0	0.000147903	0	0
C6orf10	10665	broad.mit.edu	37	6	32261009	32261009	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:32261009G>A	ENST00000375015.4	-	26	1638	c.1438C>T	c.(1438-1440)Cta>Tta	p.L480L	C6orf10_ENST00000447241.2_Silent_p.L481L|C6orf10_ENST00000442822.2_Intron|C6orf10_ENST00000375007.4_Silent_p.L479L|C6orf10_ENST00000533191.1_Silent_p.L479L|C6orf10_ENST00000527965.1_Silent_p.L465L			Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	481	Lys-rich.					integral to membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	25						TGTCCTTTTAGTACACCTGAC	0.403000													13	51					0	0	5.01169e-05	0	0
CPEB3	22849	broad.mit.edu	37	10	93851667	93851667	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:93851667T>C	ENST00000412050.4	-	8	1653	c.1565A>G	c.(1564-1566)gAc>gGc	p.D522G	CPEB3_ENST00000265997.4_Missense_Mutation_p.D536G	NM_001178137.1	NP_001171608.1	Q8NE35	CPEB3_HUMAN	cytoplasmic polyadenylation element binding protein 3	536	RRM 1.						nucleotide binding|RNA binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(5)|skin(2)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.0869)				CATTACAAAGTCACTGTCACT	0.428000													15	27					0	0	7.07596e-05	0	0
DPH2	1802	broad.mit.edu	37	1	44436352	44436352	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:44436352T>C	ENST00000255108.3	+	2	404	c.232T>C	c.(232-234)Ttc>Ctc	p.F78L	DPH2_ENST00000529729.1_3'UTR|DPH2_ENST00000396758.2_Missense_Mutation_p.F78L|DPH2_ENST00000412950.2_Silent_p.C17C	NM_001384.4	NP_001375.2	Q9BQC3	DPH2_HUMAN	DPH2 homolog (S. cerevisiae)	78					peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm				autonomic_ganglia(1)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(2)|skin(1)	19	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				GTCAAAGATGTTCATTCTGGG	0.552000													89	217					0	0	0.000147903	0	0
OR10H1	26539	broad.mit.edu	37	19	15918635	15918635	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:15918635G>A	ENST00000334920.2	-	1	301	c.213C>T	c.(211-213)atC>atT	p.I71I		NM_013940.2	NP_039228.1	Q9Y4A9	O10H1_HUMAN	olfactory receptor, family 10, subfamily H, member 1	71					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(8)|ovary(4)|skin(2)|urinary_tract(1)	29						CGGTGTAGAGGATCTCGGAGA	0.642000													17	10					0	0	7.07596e-05	0	0
TOM1L2	146691	broad.mit.edu	37	17	17797059	17797059	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:17797059G>A	ENST00000379504.3	-	4	365	c.282C>T	c.(280-282)ttC>ttT	p.F94F	TOM1L2_ENST00000318094.10_Silent_p.F94F|TOM1L2_ENST00000540946.1_Silent_p.F94F|TOM1L2_ENST00000542206.1_Intron|TOM1L2_ENST00000395739.4_Silent_p.F94F|TOM1L2_ENST00000535933.1_Silent_p.F94F|TOM1L2_ENST00000581396.1_Intron	NM_001082968.1	NP_001076437.1	Q6ZVM7	TM1L2_HUMAN	target of myb1-like 2 (chicken)	94	VHS.				intracellular protein transport	intracellular				endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|prostate(2)	10	all_neural(463;0.228)					CACTGTCGATGAAATCTCGGT	0.517000													12	65					0	0	0.000151284	0	0
SPEG	10290	broad.mit.edu	37	2	220354160	220354160	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:220354160T>G	ENST00000312358.7	+	36	8552	c.8420T>G	c.(8419-8421)cTa>cGa	p.L2807R	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2807	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		GCCCCACCCCTAGCTCCTGCT	0.662000													4	33					0	0	1.23904e-05	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49344564	49344564	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:49344564G>A	ENST00000263265.6	-	17	2302	c.1747C>T	c.(1747-1749)Ccg>Tcg	p.P583S	PLEKHA4_ENST00000355496.5_Intron	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	583						cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		CGGGCCACCGGGGCCTAGGGA	0.647000													9	26					0	0	3.86212e-05	0	0
COL6A3	1293	broad.mit.edu	37	2	238303547	238303547	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:238303547G>C	ENST00000295550.4	-	3	844	c.392C>G	c.(391-393)aCc>aGc	p.T131S	COL6A3_ENST00000347401.3_Missense_Mutation_p.T131S|COL6A3_ENST00000392004.3_Intron|COL6A3_ENST00000353578.4_Intron|COL6A3_ENST00000409809.1_Intron|COL6A3_ENST00000472056.1_Intron|COL6A3_ENST00000346358.4_Missense_Mutation_p.T131S|COL6A3_ENST00000392003.2_Intron	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	131	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		AGCAGCCTTGGTGAGGTGGCT	0.483000													7	66					0	0	8.12818e-05	0	0
PITPNM3	83394	broad.mit.edu	37	17	6387073	6387073	+	Splice_Site	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:6387073C>T	ENST00000262483.8	-	6	439		c.e6-1		ACKR6_ENST00000421306.3_Splice_Site	NM_031220.3	NP_112497.2																					GGCAGCCTTCCTGAGAGCCAA	0.627000													19	14					0	0	9.7654e-05	0	0
RRN3P2	653390	broad.mit.edu	37	16	29107453	29107453	+	RNA	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr16:29107453G>A	ENST00000564580.1	+	0	845																											TTTTTATAGGGATTCGCAGAG	0.393000													8	41					0	0	2.17888e-05	0	0
SLC12A7	10723	broad.mit.edu	37	5	1081726	1081726	+	Silent	SNP	G	G	A	rs113279957		TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr5:1081726G>A	ENST00000264930.5	-	9	1306	c.1263C>T	c.(1261-1263)acC>acT	p.T421T		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	421					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CAACCAGCAGGGTGAAGGAGG	0.607000													11	25					0	0	0.00010058	0	0
WFDC2	10406	broad.mit.edu	37	20	44108723	44108723	+	Missense_Mutation	SNP	C	C	T	rs147125152		TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr20:44108723C>T	ENST00000342873.3	+	1	645	c.212C>T	c.(211-213)cCc>cTc	p.P71L	WFDC2_ENST00000339946.3_Missense_Mutation_p.P74L|WFDC2_ENST00000372676.3_Missense_Mutation_p.P122L|WFDC2_ENST00000488143.1_3'UTR			Q14508	WFDC2_HUMAN	WAP four-disulfide core domain 2	122	WAP 1.			SL -> LLC (in Ref. 1; CAA44869 and 2; AAL37485).	proteolysis|spermatogenesis	extracellular space	serine-type endopeptidase inhibitor activity			lung(1)	1		Myeloproliferative disorder(115;0.0122)				TGTGTCACTCCCAATTTCTGA	0.567000													46	66					0	0	0.000147903	0	0
DKK2	27123	broad.mit.edu	37	4	107845320	107845320	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:107845320C>T	ENST00000285311.3	-	4	1276	c.571G>A	c.(571-573)Gaa>Aaa	p.E191K	DKK2_ENST00000513208.1_Missense_Mutation_p.E91K|DKK2_ENST00000510463.1_Missense_Mutation_p.E145K	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	191	DKK-type Cys-2.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		CAAAACCCTTCAATGCAGTCT	0.458000													10	24					0	0	2.17888e-05	0	0
UBE2J2	118424	broad.mit.edu	37	1	1203265	1203265	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:1203265G>A	ENST00000349431.6	-	2	327	c.108C>T	c.(106-108)ccC>ccT	p.P36P	UBE2J2_ENST00000400929.2_Intron|UBE2J2_ENST00000400930.4_Silent_p.P36P|UBE2J2_ENST00000347370.2_5'UTR|UBE2J2_ENST00000491779.1_Intron|UBE2J2_ENST00000360466.2_Silent_p.P36P|UBE2J2_ENST00000348298.7_5'UTR	NM_058167.2	NP_477515.2	Q8N2K1	UB2J2_HUMAN	ubiquitin-conjugating enzyme E2, J2	36					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity			cervix(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.66e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.53e-21)|Colorectal(212;0.00019)|COAD - Colon adenocarcinoma(227;0.000215)|Kidney(185;0.00255)|BRCA - Breast invasive adenocarcinoma(365;0.00266)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0371)|Lung(427;0.205)		TCGAAGGGAGGGGCTCGGCAC	0.632000													82	170					0	0	0.000147903	0	0
DIDO1	11083	broad.mit.edu	37	20	61525513	61525513	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr20:61525513G>A	ENST00000266070.4	-	12	2931	c.2606C>T	c.(2605-2607)cCg>cTg	p.P869L	DIDO1_ENST00000395343.1_Missense_Mutation_p.P869L|DIDO1_ENST00000395340.1_Missense_Mutation_p.P869L|DIDO1_ENST00000395335.2_Missense_Mutation_p.P869L	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	869					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TTGTTTTTTCGGAGCTGGCTC	0.502000													43	180					0	0	0.000147903	0	0
AGBL1	123624	broad.mit.edu	37	15	86940602	86940602	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr15:86940602C>T	ENST00000441037.2	+	17	2337	c.2242C>T	c.(2242-2244)Cgt>Tgt	p.R748C	AGBL1_ENST00000421325.2_Missense_Mutation_p.R748C|AGBL1_ENST00000389298.3_Missense_Mutation_p.R479C	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	748					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						TGCAGGACATCGTCCATATCA	0.398000													5	5					0	0	8.12818e-05	0	0
HSPA1L	3305	broad.mit.edu	37	6	31779099	31779099	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:31779099C>T	ENST00000375654.4	-	2	840	c.651G>A	c.(649-651)ggG>ggA	p.G217G	HSPA1L_ENST00000417199.3_Silent_p.G217G	NM_005527.3	NP_005518.3	P34931	HS71L_HUMAN	heat shock 70kDa protein 1-like	217					response to unfolded protein		ATP binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(10)|ovary(3)|pleura(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34						CCTCAAAAATCCCATCATCTA	0.483000													93	500					0	0	0.000147903	0	0
RBM47	54502	broad.mit.edu	37	4	40440442	40440442	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:40440442C>T	ENST00000319592.4	-	4	1178	c.469G>A	c.(469-471)Ggg>Agg	p.G157R	RBM47_ENST00000514014.1_Missense_Mutation_p.G119R|RBM47_ENST00000381795.6_Missense_Mutation_p.G157R|RBM47_ENST00000515809.1_Intron|RBM47_ENST00000381793.2_Missense_Mutation_p.G157R|RBM47_ENST00000295971.7_Missense_Mutation_p.G157R			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	157	RRM 2.					nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						TTGGGGATCCCGCCGATGAAG	0.647000													23	46					0	0	7.16444e-05	0	0
SORCS3	22986	broad.mit.edu	37	10	106924130	106924130	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:106924130G>A	ENST00000369701.3	+	12	2029	c.1802G>A	c.(1801-1803)tGg>tAg	p.W601*		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	601						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGCAACACATGGAGACAGGTA	0.443000													5	7					0	0	3.59834e-05	0	0
WDR65	149465	broad.mit.edu	37	1	43664180	43664180	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:43664180G>A	ENST00000372492.4	+	8	1615	c.1291G>A	c.(1291-1293)Gaa>Aaa	p.E431K	WDR65_ENST00000528956.1_Missense_Mutation_p.E431K	NM_001195831.2	NP_001182760.2	Q96MR6	WDR65_HUMAN	WD repeat domain 65	431										NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				GGAATACCAAGAAGAGGCATA	0.393000													11	38					0	0	0.000151284	0	0
ACE	1636	broad.mit.edu	37	17	61559936	61559936	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:61559936C>T	ENST00000290866.4	+	8	1252	c.1228C>T	c.(1228-1230)Cgg>Tgg	p.R410W	ACE_ENST00000584529.1_3'UTR|ACE_ENST00000538928.1_Missense_Mutation_p.R410W|ACE_ENST00000428043.1_Missense_Mutation_p.R410W	NM_000789.3	NP_000780.1	P12821	ACE_HUMAN	angiotensin I converting enzyme	410	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	CTCCCTGCGTCGGGGGGCCAA	0.607000													13	144					0	0	0.000422831	0	0
PTPRH	5794	broad.mit.edu	37	19	55707899	55707899	+	Missense_Mutation	SNP	C	C	T	rs145253735	by1000genomes	TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:55707899C>T	ENST00000376350.3	-	10	2270	c.2248G>A	c.(2248-2250)Gag>Aag	p.E750K	PTPRH_ENST00000588559.1_5'UTR|PTPRH_ENST00000263434.5_Missense_Mutation_p.E572K	NM_002842.3	NP_002833.3	Q9HD43	PTPRH_HUMAN	protein tyrosine phosphatase, receptor type, H	750					apoptosis	cytoplasm|integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(2)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(8)|lung(27)|ovary(2)|prostate(5)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	67		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0479)		CCTGCACTCTCGGTGTGGCAG	0.597000													17	44					0	0	0.000229342	0	0
SPATA8	145946	broad.mit.edu	37	15	97326971	97326971	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr15:97326971C>A	ENST00000328504.3	+	1	353	c.86C>A	c.(85-87)cCt>cAt	p.P29H	SPATA8_ENST00000558553.1_Intron	NM_173499.3	NP_775770.1	Q6RVD6	SPAT8_HUMAN	spermatogenesis associated 8	29										large_intestine(4)|lung(8)|ovary(1)|skin(3)	16	Melanoma(26;0.0142)|Lung NSC(78;0.041)|all_lung(78;0.0468)		OV - Ovarian serous cystadenocarcinoma(32;0.0718)			CTGCCTTGTCCTAGGTATCTG	0.522000													24	33					8.24728e-16	2.13807e-14	9.22233e-05	1	0
SCN4A	6329	broad.mit.edu	37	17	62020202	62020202	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:62020202G>A	ENST00000578147.1	-	23	4348	c.4272C>T	c.(4270-4272)gtC>gtT	p.V1424V	SCN4A_ENST00000435607.1_Silent_p.V1424V			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1424					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.V1424V(1)		breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	TGGACAGGATGACGACCACGA	0.602000													8	38					0	0	0.000274275	0	0
NRAS	4893	broad.mit.edu	37	1	115258748	115258748	+	Missense_Mutation	SNP	C	C	G	rs121913250		TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:115258748C>G	ENST00000369535.4	-	2	287	c.34G>C	c.(34-36)Ggt>Cgt	p.G12R		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	12			G -> C (in leukemia).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.G12S(133)|p.G12C(81)|p.G12R(18)|p.G12N(2)|p.G12P(1)|p.G12Y(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCAACACCACCTGCTCCAACC	0.493000	G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(MOLT4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(P31FUJ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			32	103					0	0	0.000132358	0	0
ARHGAP6	395	broad.mit.edu	37	X	11682527	11682527	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:11682527G>A	ENST00000337414.4	-	1	1294	c.422C>T	c.(421-423)tCt>tTt	p.S141F	ARHGAP6_ENST00000380732.3_Missense_Mutation_p.S141F|ARHGAP6_ENST00000380718.1_Missense_Mutation_p.S141F	NM_013427.2	NP_038286.2	O43182	RHG06_HUMAN	Rho GTPase activating protein 6	141					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						GGCCAGGACAGAAGGCAGGTC	0.627000													5	17					0	0	8.12818e-05	0	0
PSMD2	5708	broad.mit.edu	37	3	184024179	184024179	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:184024179T>A	ENST00000310118.4	+	15	2404	c.1846T>A	c.(1846-1848)Tgt>Agt	p.C616S	EIF2B5_ENST00000444495.1_Intron|PSMD2_ENST00000435761.1_Missense_Mutation_p.C457S|PSMD2_ENST00000439383.1_Missense_Mutation_p.C486S	NM_002808.3	NP_002799.3	Q13200	PSMD2_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2	616					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	enzyme regulator activity|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|liver(1)|lung(12)|prostate(3)|upper_aerodigestive_tract(2)	27	all_cancers(143;1.54e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Bortezomib(DB00188)	GCTCCACATTTGTAGCGAACA	0.488000													69	141					0	0	0.000147903	0	0
BCAM	4059	broad.mit.edu	37	19	45317959	45317959	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:45317959G>A	ENST00000391955.1	+	8	1064	c.1020G>A	c.(1018-1020)gaG>gaA	p.E340E	BCAM_ENST00000270233.6_Silent_p.E340E			P50895	BCAM_HUMAN	basal cell adhesion molecule (Lutheran blood group)	340	Ig-like C2-type 1.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				GCAGAGTGGAGGATTACGACG	0.647000													142	294					0	0	0.000147903	0	0
BAHCC1	57597	broad.mit.edu	37	17	79428154	79428154	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:79428154C>T	ENST00000307745.7	+	30	6465	c.6465C>T	c.(6463-6465)gcC>gcT	p.A2155A	RP11-1055B8.8_ENST00000572590.1_RNA																							GCTTCCGCGCCGACTCCTTCA	0.692000													4	16					0	0	1.23904e-05	0	0
SLC17A3	10786	broad.mit.edu	37	6	25862090	25862090	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:25862090G>A	ENST00000397060.4	-	4	580	c.471C>T	c.(469-471)atC>atT	p.I157I	SLC17A3_ENST00000360657.3_Intron|SLC17A3_ENST00000361703.6_Intron	NM_001098486.1	NP_001091956.1	O00476	NPT4_HUMAN	solute carrier family 17 (organic anion transporter), member 3	308					glucose-6-phosphate transport|urate metabolic process	apical plasma membrane|brush border membrane|endoplasmic reticulum membrane|integral to plasma membrane|perinuclear region of cytoplasm	drug transmembrane transporter activity|efflux transmembrane transporter activity|organic anion transmembrane transporter activity|sodium:phosphate symporter activity|toxin transporter activity|urate transmembrane transporter activity|voltage-gated anion channel activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)	20						TGGCCAGAGGGATGCATAGAG	0.443000													8	9					0	0	0.000274275	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520392	33520392	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:33520392G>C	ENST00000297307.5	-	1	1020	c.935C>G	c.(934-936)gCg>gGg	p.A312G		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	312	DUF6 2.					integral to membrane		p.A312G(4)									AACCCCTGCCGCCACGATGTC	0.567000													5	192					0	0	8.12818e-05	0	0
FAM179A	165186	broad.mit.edu	37	2	29259496	29259496	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:29259496C>T	ENST00000379558.4	+	18	2859	c.2508C>T	c.(2506-2508)ctC>ctT	p.L836L	FAM179A_ENST00000403861.2_Silent_p.L781L|FAM179A_ENST00000465300.1_3'UTR	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	836							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						TGATCCCCCTCCTCAGAGAGA	0.517000													17	49					0	0	5.01169e-05	0	0
PLIN5	440503	broad.mit.edu	37	19	4523746	4523746	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:4523746C>G	ENST00000381848.3	-	8	1266	c.1186G>C	c.(1186-1188)Gtg>Ctg	p.V396L		NM_001013706.2	NP_001013728.2	Q00G26	PLIN5_HUMAN	perilipin 5	396						lipid particle				endometrium(4)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	10						ACCTCGTCCACCAGGTCCGCC	0.731000													18	45					0	0	0.000175454	0	0
TMEM251	26175	broad.mit.edu	37	14	93652793	93652793	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:93652793C>T	ENST00000415050.2	+	2	662	c.287C>T	c.(286-288)tCc>tTc	p.S96F	TMEM251_ENST00000283534.4_Missense_Mutation_p.S58F|RP11-371E8.4_ENST00000557048.1_Intron|RP11-371E8.4_ENST00000557574.1_Missense_Mutation_p.S58F	NM_001098621.1	NP_001092091.1			transmembrane protein 251																		TGGACACACTCCTTGAAAGCT	0.423000													22	64					0	0	0.000295444	0	0
PCDH10	57575	broad.mit.edu	37	4	134072858	134072858	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:134072858G>A	ENST00000264360.4	+	1	2389	c.1563G>A	c.(1561-1563)gaG>gaA	p.E521E		NM_032961.1	NP_116586.1	Q9P2E7	PCD10_HUMAN	protocadherin 10	521	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(30)|liver(1)|lung(72)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(2)	136				LUSC - Lung squamous cell carcinoma(193;0.227)		TCAACTCTGAGAACGGCTACT	0.602000													35	86					0	0	0.000132358	0	0
ACTR2	10097	broad.mit.edu	37	2	65492226	65492226	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:65492226C>T	ENST00000260641.5	+	8	1088	c.931C>T	c.(931-933)Cct>Tct	p.P311S	ACTR2_ENST00000542850.1_Missense_Mutation_p.P256S|ACTR2_ENST00000377982.4_Missense_Mutation_p.P316S	NM_005722.3	NP_005713.1	P61160	ARP2_HUMAN	ARP2 actin-related protein 2 homolog (yeast)	311					cellular component movement	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|ATP binding			NS(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(1)|prostate(1)	12						TACTATGTATCCTGGCCTGCC	0.383000													50	110					0	0	0.000147903	0	0
ART4	420	broad.mit.edu	37	12	14993586	14993586	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:14993586C>T	ENST00000228936.4	-	2	1027	c.646G>A	c.(646-648)Gag>Aag	p.E216K	C12orf60_ENST00000527783.1_Intron	NM_021071.2	NP_066549.2	Q93070	NAR4_HUMAN	ADP-ribosyltransferase 4	216					arginine metabolic process|protein ADP-ribosylation	anchored to membrane|plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity			large_intestine(5)|liver(1)|lung(3)|prostate(1)|skin(2)|stomach(3)	15						TCCTGTGCCTCTTCTTTCAGG	0.493000													4	18					0	0	0.00024832	0	0
GAS6	2621	broad.mit.edu	37	13	114524980	114524980	+	Silent	SNP	G	G	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr13:114524980G>T	ENST00000357389.3	-	14	2114	c.1962C>A	c.(1960-1962)ctC>ctA	p.L654L	GAS6_ENST00000355761.4_Silent_p.L557L|GAS6-AS1_ENST00000458001.1_RNA|GAS6_ENST00000480426.1_5'UTR|GAS6_ENST00000327773.6_Silent_p.L611L|GAS6_ENST00000450766.1_Silent_p.L338L|GAS6_ENST00000418959.3_Silent_p.L312L			Q14393	GAS6_HUMAN	growth arrest-specific 6	654	Laminin G-like 2.				cell proliferation|leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|post-translational protein modification|proteolysis|regulation of growth	endoplasmic reticulum lumen|extracellular space|Golgi lumen|platelet alpha granule lumen	calcium ion binding|receptor agonist activity			central_nervous_system(4)|ovary(1)	5	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0176)|all_epithelial(44;0.0104)|all_lung(25;0.0249)|Lung NSC(25;0.0908)|Breast(118;0.188)				GGTGCCTCTCGAGCACGGCCA	0.716000													4	4					0.00024832	0.0063151	0.00024832	1	0
IQCC	55721	broad.mit.edu	37	1	32673199	32673199	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:32673199G>A	ENST00000537469.1	+	5	1204	c.1157G>A	c.(1156-1158)aGa>aAa	p.R386K	IQCC_ENST00000291358.6_Missense_Mutation_p.R306K	NM_001160042.1	NP_001153514.1	Q4KMZ1	IQCC_HUMAN	IQ motif containing C	306										endometrium(4)|large_intestine(1)|lung(3)|ovary(4)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				GACGATGGAAGACAGACCTTT	0.552000													7	52					0	0	8.12818e-05	0	0
OR1E1	8387	broad.mit.edu	37	17	3301419	3301419	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:3301419C>T	ENST00000322608.2	-	1	285	c.286G>A	c.(286-288)Gac>Aac	p.D96N		NM_003553.2	NP_003544.2	P30953	OR1E1_HUMAN	olfactory receptor, family 1, subfamily E, member 1	96					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(2)|lung(5)	10						GTCAGGCAGTCCGCATAGGGG	0.522000													16	26					0	0	5.01169e-05	0	0
ABCC9	10060	broad.mit.edu	37	12	22025665	22025665	+	Splice_Site	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:22025665C>T	ENST00000261200.4	-	16	2092		c.e16-1		RP11-729I10.2_ENST00000539874.1_RNA|ABCC9_ENST00000345162.2_Splice_Site|ABCC9_ENST00000261201.4_Splice_Site	NM_020297.2	NP_064693.2	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 9						defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			NS(2)|breast(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|lung(56)|ovary(4)|pancreas(1)|prostate(4)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(5)	118					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GTTAACTGACCTAGGAAAGCA	0.403000													45	103					0	0	0.000147903	0	0
DNM1P46	196968	broad.mit.edu	37	15	100332264	100332264	+	RNA	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr15:100332264C>T	ENST00000341853.1	-	0	1927					NR_003260.1																						GACTAGGGGCCAGTCTGTGAG	0.657000													11	50					0	0	6.40141e-05	0	0
ARMC4	55130	broad.mit.edu	37	10	28225687	28225687	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:28225687C>T	ENST00000305242.5	-	15	2312	c.2220G>A	c.(2218-2220)tgG>tgA	p.W740*	ARMC4_ENST00000537576.1_Nonsense_Mutation_p.W432*|ARMC4_ENST00000545014.1_Nonsense_Mutation_p.W265*	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	740							binding	p.W740*(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						TGGAACATTTCCATATAGCCC	0.443000													8	45					0	0	3.86212e-05	0	0
OR51I2	390064	broad.mit.edu	37	11	5475540	5475540	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:5475540C>T	ENST00000341449.2	+	1	903	c.822C>T	c.(820-822)gtC>gtT	p.V274V	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron	NM_001004754.2	NP_001004754.1	Q9H344	O51I2_HUMAN	olfactory receptor, family 51, subfamily I, member 2	274					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.09e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACATACATGTCCTCATGTCAA	0.478000													23	96					0	0	9.22233e-05	0	0
ACVRL1	94	broad.mit.edu	37	12	52306947	52306947	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:52306947G>A	ENST00000550683.1	+	2	269	c.168G>A	c.(166-168)aaG>aaA	p.K56K	ACVRL1_ENST00000419526.2_Intron|ACVRL1_ENST00000388922.4_Silent_p.K42K	NM_001077401.1	NP_001070869.1	P37023	ACVL1_HUMAN	activin A receptor type II-like 1	42					blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	CACATTGCAAGGGGCCTACCT	0.672000													9	21					0	0	2.17888e-05	0	0
ECE2	9718	broad.mit.edu	37	3	184009945	184009945	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:184009945C>T	ENST00000402825.3	+	19	2571	c.2571C>T	c.(2569-2571)tcC>tcT	p.S857S	ECE2_ENST00000404464.3_Silent_p.S739S|ECE2_ENST00000359140.4_Silent_p.S710S|EIF2B5_ENST00000444495.1_Intron|ECE2_ENST00000357474.5_Silent_p.S785S	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	857	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCACTCTCTCCAACTCCCGTG	0.662000													12	60					0	0	0.00010058	0	0
NPHS2	7827	broad.mit.edu	37	1	179520438	179520438	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:179520438G>A	ENST00000367615.4	-	8	1090	c.1022C>T	c.(1021-1023)cCt>cTt	p.P341L	AXDND1_ENST00000367618.3_Intron|NPHS2_ENST00000367616.4_Missense_Mutation_p.P273L	NM_014625.2	NP_055440.1	Q9NP85	PODO_HUMAN	nephrosis 2, idiopathic, steroid-resistant (podocin)	341					excretion	integral to plasma membrane	protein binding			NS(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	20						AAATGGCAAAGGTAAAACCAC	0.522000													11	26					0	0	0.000151284	0	0
FLG	2312	broad.mit.edu	37	1	152285890	152285890	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:152285890C>T	ENST00000368799.1	-	3	1507	c.1472G>A	c.(1471-1473)gGa>gAa	p.G491E	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	491	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTTGTCTTCCTCCAGTGCT	0.607000									Ichthyosis				36	112					0	0	8.91981e-05	0	0
AK7	122481	broad.mit.edu	37	14	96953373	96953373	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:96953373G>A	ENST00000267584.4	+	17	2157	c.2113G>A	c.(2113-2115)Gaa>Aaa	p.E705K		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	705	DPY-30.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		CGTCCGACCCGAAGACCCTGT	0.413000													38	90					0	0	0.000147903	0	0
U2SURP	23350	broad.mit.edu	37	3	142769799	142769799	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:142769799C>T	ENST00000397933.2	+	24	2618	c.1336C>T	c.(1336-1338)Cag>Tag	p.Q446*	U2SURP_ENST00000493598.2_Nonsense_Mutation_p.Q854*|U2SURP_ENST00000473835.2_Nonsense_Mutation_p.Q855*			O15042	SR140_HUMAN	U2 snRNP-associated SURP domain containing	855					RNA processing	nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	31						TATGAAGTTTCAGGATGAATT	0.333000													11	52					0	0	6.40141e-05	0	0
CDH6	1004	broad.mit.edu	37	5	31305298	31305298	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr5:31305298G>A	ENST00000265071.2	+	7	1282	c.1017G>A	c.(1015-1017)aaG>aaA	p.K339K	CDH6_ENST00000514738.1_Silent_p.K284K	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	339	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						ACTTTGAAAAGAAGAAAGTGT	0.438000													10	12					0	0	0.00010058	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262123	140262123	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr5:140262123C>T	ENST00000289272.2	+	1	270	c.270C>T	c.(268-270)atC>atT	p.I90I	PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA13_ENST00000409494.1_Silent_p.I90I	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTCTCGGATCGACCGCGAGG	0.592000													74	126					0	0	0.000147903	0	0
DTNBP1	84062	broad.mit.edu	37	6	15523240	15523240	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:15523240G>A	ENST00000344537.5	-	10	1194	c.1022C>T	c.(1021-1023)gCc>gTc	p.A341V	DTNBP1_ENST00000355917.3_Missense_Mutation_p.A342V|DTNBP1_ENST00000462989.2_Missense_Mutation_p.A185V	NM_032122.4	NP_115498.2	Q96EV8	DTBP1_HUMAN	dystrobrevin binding protein 1	341					actin cytoskeleton reorganization|cellular membrane organization|neuron projection morphogenesis|post-Golgi vesicle-mediated transport|regulation of dopamine receptor signaling pathway	axon part|BLOC-1 complex|cell junction|dendritic spine|endoplasmic reticulum membrane|endosome membrane|growth cone|melanosome membrane|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|synaptic vesicle membrane|synaptosome	identical protein binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|skin(2)	14	Breast(50;0.0289)|Ovarian(93;0.103)	all_hematologic(90;0.0895)	Epithelial(50;0.211)			ATCCGGAGTGGCCTCTCTGTC	0.572000									Hermansky-Pudlak syndrome				36	97					0	0	0.000132358	0	0
AKAP13	11214	broad.mit.edu	37	15	86259042	86259042	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr15:86259042C>T	ENST00000394518.2	+	20	5718	c.5623C>T	c.(5623-5625)Cgg>Tgg	p.R1875W	AKAP13_ENST00000361243.2_Missense_Mutation_p.R1879W|AKAP13_ENST00000560579.1_3'UTR|AKAP13_ENST00000394510.2_Missense_Mutation_p.R120W	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1875					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						GGAGCGTCCTCGGTCCGCAGT	0.532000													14	47					0	0	0.000151284	0	0
SPINK14	408187	broad.mit.edu	37	5	147549340	147549340	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr5:147549340G>A	ENST00000356972.1	+	1	45	c.45G>A	c.(43-45)ttG>ttA	p.L15L	SPINK14_ENST00000562793.1_Silent_p.L15L	NM_001001325.1	NP_001001325.1	Q6IE38	ISK14_HUMAN	serine peptidase inhibitor, Kazal type 14 (putative)	15						extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|large_intestine(1)|lung(1)	3						CCTTTATCTTGATACATTTGG	0.393000													6	3					0	0	3.59834e-05	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155935153	155935153	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:155935153G>A	ENST00000368316.1	-	10	910	c.440C>T	c.(439-441)tCc>tTc	p.S147F	ARHGEF2_ENST00000361247.4_Missense_Mutation_p.S174F|ARHGEF2_ENST00000313695.7_Missense_Mutation_p.S147F|ARHGEF2_ENST00000368315.3_Missense_Mutation_p.S175F|ARHGEF2_ENST00000313667.4_Missense_Mutation_p.S174F			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2	174					actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					GGAGTCTGTGGACTGTGAGAG	0.577000													30	54					0	0	0.000132358	0	0
ZNF480	147657	broad.mit.edu	37	19	52817502	52817502	+	Silent	SNP	T	T	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:52817502T>C	ENST00000595962.1	+	3	235	c.169T>C	c.(169-171)Ttg>Ctg	p.L57L	ZNF480_ENST00000334564.7_Silent_p.L57L|ZNF480_ENST00000490272.1_Intron|ZNF480_ENST00000335090.6_Intron|CTD-2525I3.6_ENST00000594379.1_RNA	NM_144684.2	NP_653285.2	Q8WV37	ZN480_HUMAN	zinc finger protein 480	57	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	12				GBM - Glioblastoma multiforme(134;0.00212)|OV - Ovarian serous cystadenocarcinoma(262;0.00369)		GGATGTGATGTTGGAGAACTA	0.522000													9	26					0	0	2.17888e-05	0	0
WARS2	10352	broad.mit.edu	37	1	119575597	119575597	+	Silent	SNP	T	T	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:119575597T>C	ENST00000235521.4	-	6	1046	c.1020A>G	c.(1018-1020)gcA>gcG	p.A340A	WARS2_ENST00000537870.1_Silent_p.A246A|WARS2_ENST00000369426.5_3'UTR	NM_015836.3|NM_201263.2	NP_056651.1|NP_957715.1	Q9UGM6	SYWM_HUMAN	tryptophanyl tRNA synthetase 2, mitochondrial	340					tryptophanyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|tryptophan-tRNA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(2)	15	all_neural(166;0.187)	all_lung(203;2.48e-06)|Lung NSC(69;1.74e-05)|all_epithelial(167;0.000564)		Lung(183;0.0629)	L-Tryptophan(DB00150)	CTTTGGCTTTTGCTGATCCAA	0.408000													36	107					0	0	0.000109025	0	0
OR2T1	26696	broad.mit.edu	37	1	248569723	248569723	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:248569723C>T	ENST00000366474.1	+	1	428	c.428C>T	c.(427-429)tCc>tTc	p.S143F		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	143					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGGACCATTTCCTTTGTGGGG	0.473000													12	14					0	0	6.40141e-05	0	0
SLC13A2	9058	broad.mit.edu	37	17	26818751	26818751	+	Silent	SNP	C	C	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:26818751C>A	ENST00000444914.3	+	6	1326	c.906C>A	c.(904-906)ctC>ctA	p.L302L	SLC13A2_ENST00000537681.1_Silent_p.L182L|SLC13A2_ENST00000314669.5_Silent_p.L253L|SLC13A2_ENST00000545060.1_Silent_p.L210L	NM_001145975.1	NP_001139447.1	Q13183	S13A2_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	253						integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	CCTTCAGGCTCTTCCCCCAAA	0.602000													15	70					6.72482e-11	1.7359e-09	0.000308642	1	0
PLIN5	440503	broad.mit.edu	37	19	4523747	4523747	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:4523747C>T	ENST00000381848.3	-	8	1265	c.1185G>A	c.(1183-1185)ctG>ctA	p.L395L		NM_001013706.2	NP_001013728.2	Q00G26	PLIN5_HUMAN	perilipin 5	395						lipid particle				endometrium(4)|lung(3)|skin(2)|upper_aerodigestive_tract(1)	10						CCTCGTCCACCAGGTCCGCCA	0.731000													18	46					0	0	0.000175454	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41450753	41450753	+	RNA	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:41450753C>T	ENST00000599198.1	+	0	1344					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						TCCCCTTCTCCTTAGGTAAGC	0.453000													11	71					0	0	0.000219431	0	0
FBXL18	80028	broad.mit.edu	37	7	5521422	5521422	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:5521422G>A	ENST00000382368.3	-	5	2264	c.2141C>T	c.(2140-2142)cCg>cTg	p.P714L		NM_024963.4	NP_079239.3	Q96ME1	FXL18_HUMAN	F-box and leucine-rich repeat protein 18	0									FBXL18/RNF216(2)	central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(3)	21		Ovarian(82;0.0607)		UCEC - Uterine corpus endometrioid carcinoma (126;0.181)|OV - Ovarian serous cystadenocarcinoma(56;3.64e-13)		CCACAGGTTCGGCGGTTCCTC	0.632000													62	118					0	0	0.000147903	0	0
C6orf118	168090	broad.mit.edu	37	6	165715662	165715662	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:165715662T>A	ENST00000230301.8	-	2	169	c.149A>T	c.(148-150)aAa>aTa	p.K50I	C6orf118_ENST00000543069.1_5'UTR	NM_144980.3	NP_659417.2	Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	50										breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CCGGTGGTCTTTCTGAAGCCG	0.547000													41	40					0	0	0.000437636	0	0
ZFHX4	79776	broad.mit.edu	37	8	77768164	77768164	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:77768164G>A	ENST00000521891.2	+	10	9455	c.9007G>A	c.(9007-9009)Gaa>Aaa	p.E3003K	ZFHX4_ENST00000050961.6_Missense_Mutation_p.E2958K|ZFHX4_ENST00000455469.2_Missense_Mutation_p.E2958K|ZFHX4_ENST00000518282.1_Missense_Mutation_p.E2977K	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2958						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGGCGGAACGGAAGGCACCAA	0.458000										HNSCC(33;0.089)			4	8					0	0	0.00024832	0	0
WBSCR17	64409	broad.mit.edu	37	7	70800662	70800662	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:70800662C>T	ENST00000333538.5	+	2	999	c.365C>T	c.(364-366)tCa>tTa	p.S122L	WBSCR17_ENST00000498380.2_3'UTR	NM_022479.1	NP_071924.1	Q6IS24	GLTL3_HUMAN	Williams-Beuren syndrome chromosome region 17	122						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			NS(5)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(7)|large_intestine(22)|lung(45)|ovary(2)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	100		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				GGCTACAATTCATACCTCAGT	0.502000													7	25					0	0	0.000274275	0	0
SQSTM1	8878	broad.mit.edu	37	5	179260650	179260650	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr5:179260650G>A	ENST00000389805.4	+	7	1211	c.1033G>A	c.(1033-1035)Gaa>Aaa	p.E345K	SQSTM1_ENST00000360718.5_Missense_Mutation_p.E261K|SQSTM1_ENST00000510187.1_Intron|SQSTM1_ENST00000402874.3_Missense_Mutation_p.E261K|SQSTM1_ENST00000376929.3_Missense_Mutation_p.E261K	NM_003900.4	NP_003891.1	Q13501	SQSTM_HUMAN	sequestosome 1	345	Interaction with NTRK1 (By similarity).				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	NS(1)|breast(1)|endometrium(1)|large_intestine(2)|liver(2)|lung(5)|ovary(1)	13	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTCTTCAAAAGAAGTGGACCC	0.542000													14	36					0	0	0.000219431	0	0
CTAGE1	64693	broad.mit.edu	37	18	19996016	19996016	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr18:19996016C>T	ENST00000391403.2	-	1	1862	c.1759G>A	c.(1759-1761)Gct>Act	p.A587T		NM_172241.2	NP_758441.2	Q96RT6	CTGE2_HUMAN	cutaneous T-cell lymphoma-associated antigen 1	587						integral to membrane				cervix(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(19)|ovary(1)	27	all_cancers(21;0.000361)|all_epithelial(16;9.61e-06)|Colorectal(14;0.0533)|Lung NSC(20;0.0605)|Ovarian(2;0.116)|all_lung(20;0.135)					GGAGGGAGAGCTGAATCAGGA	0.473000													21	42					0	0	0.000295444	0	0
C16orf45	89927	broad.mit.edu	37	16	15609187	15609187	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr16:15609187G>A	ENST00000300006.4	+	2	491	c.132G>A	c.(130-132)gcG>gcA	p.A44A	C16orf45_ENST00000452191.2_Silent_p.A27A|RP11-1021N1.1_ENST00000568222.1_3'UTR|C16orf45_ENST00000566490.1_Silent_p.A44A	NM_033201.2	NP_149978.1	Q96MC5	CP045_HUMAN	chromosome 16 open reading frame 45	44										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(3)|ovary(1)	11						TCTCCATGGCGGAGACAACCA	0.547000													18	35					0	0	0.000229342	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947716	57947716	+	Missense_Mutation	SNP	C	C	T	rs142831243		TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:57947716C>T	ENST00000335397.3	+	3	1116	c.800C>T	c.(799-801)tCg>tTg	p.S267L		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				GATCAGTCTTCGGAGAAGAAT	0.512000													4	15					0	0	0.00024832	0	0
RBBP6	5930	broad.mit.edu	37	16	24581764	24581764	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr16:24581764C>T	ENST00000319715.4	+	17	4185	c.3753C>T	c.(3751-3753)gtC>gtT	p.V1251V	RBBP6_ENST00000381039.3_Intron|RBBP6_ENST00000348022.2_Silent_p.V1217V	NM_006910.4	NP_008841.2	Q7Z6E9	RBBP6_HUMAN	retinoblastoma binding protein 6	1251					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(4)|pancreas(1)|prostate(2)|urinary_tract(1)	46				GBM - Glioblastoma multiforme(48;0.0518)		AAGGAAAGGTCAGACGAAAAG	0.413000													17	54					0	0	7.07596e-05	0	0
SF3B1	23451	broad.mit.edu	37	2	198265476	198265476	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:198265476T>C	ENST00000335508.5	-	18	2772	c.2681A>G	c.(2680-2682)gAt>gGt	p.D894G		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa	894					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding	p.D894G(1)		NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			AAGAATACCATCAATCAGTTG	0.333000			Mis		myelodysplastic syndrome								12	25					0	0	0.000219431	0	0
ERN2	10595	broad.mit.edu	37	16	23702489	23702489	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr16:23702489C>T	ENST00000256797.4	-	21	2841	c.2673G>A	c.(2671-2673)ggG>ggA	p.G891G	ERN2_ENST00000457008.2_Silent_p.G791G	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	843	KEN.				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GCACTGATGTCCCCTTATAGG	0.617000													43	103					0	0	0.000147903	0	0
ZAN	7455	broad.mit.edu	37	7	100350192	100350192	+	RNA	SNP	C	C	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:100350192C>A	ENST00000542585.1	+	0	2612				ZAN_ENST00000538115.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000421100.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CATGGAAAAACCCACTCTCCC	0.512000													12	116					2.62699e-14	6.79571e-13	0.000308642	1	0
HIVEP2	3097	broad.mit.edu	37	6	143092937	143092937	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:143092937G>A	ENST00000367603.2	-	5	3681	c.2939C>T	c.(2938-2940)tCc>tTc	p.S980F	HIVEP2_ENST00000012134.2_Missense_Mutation_p.S980F|HIVEP2_ENST00000367604.1_Missense_Mutation_p.S980F	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	980	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		AAAAGACATGGAGAAACTGGA	0.512000													42	61					0	0	0.000437636	0	0
OCRL	4952	broad.mit.edu	37	X	128691357	128691357	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:128691357C>T	ENST00000371113.4	+	5	459	c.294C>T	c.(292-294)atC>atT	p.I98I	OCRL_ENST00000486673.1_3'UTR|OCRL_ENST00000357121.5_Silent_p.I98I	NM_000276.3	NP_000267.2	Q01968	OCRL_HUMAN	oculocerebrorenal syndrome of Lowe	98					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(24)|ovary(2)|upper_aerodigestive_tract(3)	48						GCTTTGAAATCCCTGATGAGG	0.433000													36	47					0	0	0.000437636	0	0
WDR3	10885	broad.mit.edu	37	1	118499811	118499811	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:118499811C>T	ENST00000349139.4	+	25	2621	c.2574C>T	c.(2572-2574)ttC>ttT	p.F858F	SPAG17_ENST00000336338.5_Intron	NM_006784.2	NP_006775.1	Q9UNX4	WDR3_HUMAN	WD repeat domain 3	858						nuclear membrane|nucleolus				breast(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(9)|liver(2)|lung(22)|prostate(2)|upper_aerodigestive_tract(1)	49	Esophageal squamous(2;0.162)	all_cancers(81;2.72e-05)|Acute lymphoblastic leukemia(138;1e-08)|all_epithelial(167;4.4e-07)|all_lung(203;1.7e-06)|Lung NSC(69;1.98e-05)|Prostate(1639;0.00955)|Breast(1374;0.244)		OV - Ovarian serous cystadenocarcinoma(397;1.39e-08)|Epithelial(280;1.82e-07)|all cancers(265;2.04e-05)|Lung(183;0.0525)|BRCA - Breast invasive adenocarcinoma(282;0.0695)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.185)		GCCTCTTCTTCCTCCTTAGGT	0.413000													10	66					0	0	0.000151284	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913863	77913863	+	Missense_Mutation	SNP	G	G	A	rs148985625		TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:77913863G>A	ENST00000321110.1	-	2	350	c.55C>T	c.(55-57)Cgg>Tgg	p.R19W		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	19							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						TGAGCCTGCCGAATTTCATTC	0.463000													6	37					0	0	8.12818e-05	0	0
SRCIN1	80725	broad.mit.edu	37	17	36708983	36708983	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:36708983C>T	ENST00000264659.7	-	12	2534	c.2310G>A	c.(2308-2310)ggG>ggA	p.G770G	SRCIN1_ENST00000578925.1_Silent_p.G804G|SRCIN1_ENST00000398579.4_5'UTR	NM_025248.2	NP_079524.2	Q9C0H9	SRCN1_HUMAN	SRC kinase signaling inhibitor 1	642					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	19						TCAGCGTCTCCCCGAGCTGCT	0.617000													52	36					0	0	0.000147903	0	0
EN2	2020	broad.mit.edu	37	7	155255099	155255099	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:155255099C>T	ENST00000297375.4	+	2	968	c.719C>T	c.(718-720)cCg>cTg	p.P240L		NM_001427.3	NP_001418.2	P19622	HME2_HUMAN	engrailed homeobox 2	240						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(1)|lung(2)	4	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AAGAAGAACCCGAACAAAGAG	0.597000													10	80					0	0	2.17888e-05	0	0
PDE1A	5136	broad.mit.edu	37	2	183099217	183099217	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:183099217C>T	ENST00000435564.1	-	4	607	c.407G>A	c.(406-408)cGa>cAa	p.R136Q	PDE1A_ENST00000456212.1_Missense_Mutation_p.R136Q|PDE1A_ENST00000482538.1_5'UTR|PDE1A_ENST00000536095.1_Missense_Mutation_p.R32Q|PDE1A_ENST00000331935.6_Missense_Mutation_p.R136Q|PDE1A_ENST00000410103.1_Missense_Mutation_p.R136Q|PDE1A_ENST00000358139.2_Missense_Mutation_p.R136Q|PDE1A_ENST00000346717.4_Missense_Mutation_p.R102Q|PDE1A_ENST00000351439.5_Missense_Mutation_p.R120Q|PDE1A_ENST00000409365.1_Missense_Mutation_p.R120Q	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	136					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			ATATGTTTTTCGGTACATTCT	0.269000													28	51					0	0	0.000279167	0	0
CTPS2	56474	broad.mit.edu	37	X	16688706	16688706	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:16688706G>A	ENST00000443824.1	-	11	1929	c.1186C>T	c.(1186-1188)Ctg>Ttg	p.L396L	CTPS2_ENST00000359276.4_Silent_p.L396L|CTPS2_ENST00000380241.3_Silent_p.L396L	NM_001144002.1	NP_001137474.1	Q9NRF8	PYRG2_HUMAN	CTP synthase 2	396	Glutamine amidotransferase type-1.				glutamine metabolic process|nucleobase, nucleoside and nucleotide interconversion|pyrimidine nucleotide biosynthetic process	cytosol	ATP binding|CTP synthase activity			breast(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	Hepatocellular(33;0.0997)					GTTTTACCCAGAAAAGGAATC	0.403000													75	178					0	0	0.000147903	0	0
DUSP18	150290	broad.mit.edu	37	22	31059613	31059613	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr22:31059613G>A	ENST00000403268.1	-	3	738	c.268C>T	c.(268-270)Cct>Tct	p.P90S	DUSP18_ENST00000334679.3_Silent_p.S126S|DUSP18_ENST00000407308.1_Silent_p.S126S|DUSP18_ENST00000461301.1_Intron|DUSP18_ENST00000404885.1_Silent_p.S126S			Q8NEJ0	DUS18_HUMAN	dual specificity phosphatase 18	0	Tyrosine-protein phosphatase.					cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			large_intestine(1)|lung(1)|prostate(1)|skin(1)	4						CGTCCAGCAGGGACATGGCGT	0.587000													5	65					0	0	1.23904e-05	0	0
IGLV1-51	28820	broad.mit.edu	37	22	22677150	22677150	+	RNA	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr22:22677150C>T	ENST00000390290.2	+	0	214				LL22NC03-80A10.6_ENST00000426066.1_RNA																							CCAGCAGCTCCCAGGAACAGC	0.542000													84	74					0	0	0.000147903	0	0
PRR12	57479	broad.mit.edu	37	19	50105142	50105142	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:50105142C>T	ENST00000418929.2	+	6	4752	c.4740C>T	c.(4738-4740)ttC>ttT	p.F1580F		NM_020719.1	NP_065770.1	Q9ULL5	PRR12_HUMAN	proline rich 12	759							DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)|prostate(2)	11		all_lung(116;2.45e-07)|Lung NSC(112;1.24e-06)|Ovarian(192;0.0728)|all_neural(266;0.0887)		OV - Ovarian serous cystadenocarcinoma(262;0.00319)|GBM - Glioblastoma multiforme(134;0.0132)		GGGACGAGTTCGTCATCCGTG	0.612000													6	38					0	0	3.59834e-05	0	0
OR4D10	390197	broad.mit.edu	37	11	59245544	59245544	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:59245544C>T	ENST00000530162.1	+	1	699	c.642C>T	c.(640-642)ctC>ctT	p.L214L		NM_001004705.1	NP_001004705.1	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D, member 10	214					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TTTTCCTGCTCCTGGTGTCCT	0.488000													6	17					0	0	3.59834e-05	0	0
TAF8	129685	broad.mit.edu	37	6	42025228	42025228	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:42025228C>T	ENST00000372977.3	+	5	484	c.466C>T	c.(466-468)Ccc>Tcc	p.P156S	TAF8_ENST00000494547.1_Missense_Mutation_p.P156S|TAF8_ENST00000456846.2_Missense_Mutation_p.P156S|TAF8_ENST00000482926.1_3'UTR|TAF8_ENST00000465926.1_Missense_Mutation_p.P93S|TAF8_ENST00000372978.3_Missense_Mutation_p.P156S|TAF8_ENST00000372982.4_Missense_Mutation_p.P156S	NM_138572.2	NP_612639.2	Q7Z7C8	TAF8_HUMAN	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa	156					cell differentiation|maintenance of protein location in nucleus|positive regulation of transcription, DNA-dependent|regulation of fat cell differentiation|transcription, DNA-dependent	perinuclear region of cytoplasm|transcription factor TFIID complex	DNA binding|protein binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)	6	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00179)			GTTCCCTGATCCCCACACCTA	0.592000													10	38					0	0	6.40141e-05	0	0
TECRL	253017	broad.mit.edu	37	4	65180469	65180469	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:65180469C>T	ENST00000381210.3	-	5	558	c.448G>A	c.(448-450)Gaa>Aaa	p.E150K	TECRL_ENST00000507440.1_Missense_Mutation_p.E150K|TECRL_ENST00000513125.1_5'UTR	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	150					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						CCTGTGTATTCAGCCAAAAAC	0.348000													13	36					0	0	0.00010058	0	0
OR2Z1	284383	broad.mit.edu	37	19	8841477	8841477	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:8841477C>T	ENST00000324060.2	+	1	162	c.87C>T	c.(85-87)tcC>tcT	p.S29S		NM_001004699.1	NP_001004699.1	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z, member 1	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						TCCTCTTCTCCCTGGTGGCTG	0.537000													17	25					0	0	7.07596e-05	0	0
MS4A15	219995	broad.mit.edu	37	11	60541316	60541316	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:60541316G>A	ENST00000405633.3	+	6	584	c.505G>A	c.(505-507)Gac>Aac	p.D169N	MS4A15_ENST00000528170.1_Missense_Mutation_p.D128N|MS4A15_ENST00000337911.4_Missense_Mutation_p.D76N	NM_001098835.1	NP_001092305.1	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member 15	169						integral to membrane	receptor activity			breast(1)|large_intestine(2)|lung(3)	6						CCAGGATGTGGACAGGGGCTA	0.572000													19	68					0	0	0.000229342	0	0
ZFHX4	79776	broad.mit.edu	37	8	77768230	77768230	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:77768230C>T	ENST00000521891.2	+	10	9521	c.9073C>T	c.(9073-9075)Cac>Tac	p.H3025Y	ZFHX4_ENST00000050961.6_Missense_Mutation_p.H2980Y|ZFHX4_ENST00000455469.2_Missense_Mutation_p.H2980Y|ZFHX4_ENST00000518282.1_Missense_Mutation_p.H2999Y	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2980						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CATCAGAGATCACATTTTCTC	0.527000										HNSCC(33;0.089)			5	15					0	0	1.23904e-05	0	0
OFD1	8481	broad.mit.edu	37	X	13757012	13757012	+	Silent	SNP	T	T	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:13757012T>C	ENST00000340096.6	+	4	687	c.360T>C	c.(358-360)acT>acC	p.T120T	OFD1_ENST00000380550.3_Silent_p.T120T|OFD1_ENST00000398395.3_Silent_p.T120T|OFD1_ENST00000380567.1_5'UTR|OFD1_ENST00000490265.1_3'UTR	NM_003611.2	NP_003602.1	O75665	OFD1_HUMAN	oral-facial-digital syndrome 1	120					cilium movement involved in determination of left/right asymmetry|G2/M transition of mitotic cell cycle	centriole|cilium|cytosol|microtubule basal body|nuclear membrane	alpha-tubulin binding|gamma-tubulin binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	25						TCAACCCTACTTCCAGTCTCT	0.279000													31	151					0	0	0.000159656	0	0
NR4A2	4929	broad.mit.edu	37	2	157182748	157182748	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:157182748G>A	ENST00000339562.4	-	7	1816	c.1454C>T	c.(1453-1455)tCc>tTc	p.S485F	NR4A2_ENST00000409108.2_Intron|NR4A2_ENST00000426264.1_Missense_Mutation_p.S422F|NR4A2_ENST00000409572.1_Missense_Mutation_p.S485F|NR4A2_ENST00000429376.1_Intron|NR4A2_ENST00000539077.1_Missense_Mutation_p.S496F	NM_006186.3	NP_006177.1	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	485					cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	40						TTCAACAATGGAATCAATCCA	0.488000													22	56					0	0	0.000117367	0	0
CPXM1	56265	broad.mit.edu	37	20	2775247	2775247	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr20:2775247G>A	ENST00000380605.2	-	13	1963	c.1899C>T	c.(1897-1899)gaC>gaT	p.D633D		NM_001184699.1|NM_019609.4	NP_001171628.1|NP_062555.1	Q96SM3	CPXM1_HUMAN	carboxypeptidase X (M14 family), member 1	633					cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(8)|lung(17)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						CAAGCTCCGTGTCCTTGTCCC	0.567000													34	77					0	0	8.96297e-05	0	0
SORCS2	57537	broad.mit.edu	37	4	7705995	7705995	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:7705995G>A	ENST00000507866.2	+	14	1961	c.1852G>A	c.(1852-1854)Gag>Aag	p.E618K	SORCS2_ENST00000329016.9_Missense_Mutation_p.E446K	NM_020777.2	NP_065828.2	Q96PQ0	SORC2_HUMAN	sortilin-related VPS10 domain containing receptor 2	618						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(8)|lung(8)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	42						GCCAGGGGACGAGACGCTGGT	0.657000													6	20					0	0	3.59834e-05	0	0
ARAF	369	broad.mit.edu	37	X	47426121	47426121	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:47426121C>T	ENST00000377045.4	+	7	835	c.641C>T	c.(640-642)tCc>tTc	p.S214F	ARAF_ENST00000290277.6_Intron	NM_001256196.1|NM_001654.4	NP_001243125.1|NP_001645.1	P10398	ARAF_HUMAN	v-raf murine sarcoma 3611 viral oncogene homolog	214					intracellular signal transduction|negative regulation of apoptosis|positive regulation of peptidyl-serine phosphorylation		ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|receptor signaling protein activity	p.S214F(1)		biliary_tract(1)|endometrium(4)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	29					Adenosine triphosphate(DB00171)	CGCTCCACGTCCACTCCCAAC	0.662000													5	20					0	0	1.23904e-05	0	0
FAM3B	54097	broad.mit.edu	37	21	42720632	42720632	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr21:42720632C>T	ENST00000398652.3	+	8	782	c.716C>T	c.(715-717)tCc>tTc	p.S239F	FAM3B_ENST00000398646.3_Missense_Mutation_p.S223F|FAM3B_ENST00000357985.2_Missense_Mutation_p.S200F|FAM3B_ENST00000479810.2_3'UTR|FAM3B_ENST00000398647.3_Missense_Mutation_p.S152F			P58499	FAM3B_HUMAN	family with sequence similarity 3, member B	200					apoptosis|insulin secretion	extracellular space	cytokine activity			central_nervous_system(2)|endometrium(1)|lung(2)	5		Prostate(19;1.57e-07)|all_epithelial(19;0.0404)				GAACTCCCTTCCGAAATTCAG	0.423000													25	53					0	0	0.000147802	0	0
CHGB	1114	broad.mit.edu	37	20	5903925	5903925	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr20:5903925G>A	ENST00000378961.4	+	4	1339	c.1135G>A	c.(1135-1137)Gag>Aag	p.E379K		NM_001819.2	NP_001810.2	P05060	SCG1_HUMAN	chromogranin B (secretogranin 1)	379						extracellular region	hormone activity			breast(7)|kidney(2)|large_intestine(8)|lung(19)|ovary(1)|pancreas(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	47						TCAGAGTGAGGAGAGTTGGGA	0.532000													19	59					0	0	0.000175454	0	0
NPEPL1	79716	broad.mit.edu	37	20	57269626	57269626	+	Missense_Mutation	SNP	C	C	A	rs139042887	by1000genomes	TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr20:57269626C>A	ENST00000356091.6	+	3	773	c.485C>A	c.(484-486)cCg>cAg	p.P162Q	NPEPL1_ENST00000525817.1_Missense_Mutation_p.P114Q|STX16-NPEPL1_ENST00000530122.1_3'UTR|NPEPL1_ENST00000525967.1_Missense_Mutation_p.P134Q	NM_024663.3	NP_078939.3	Q8NDH3	PEPL1_HUMAN	aminopeptidase-like 1	162					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			GACAACGGGCCGGTGGAGGTG	0.652000													14	18					1.49906e-05	0.000386128	0.000219431	1	0
MS4A15	219995	broad.mit.edu	37	11	60541315	60541315	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:60541315G>A	ENST00000405633.3	+	6	583	c.504G>A	c.(502-504)gtG>gtA	p.V168V	MS4A15_ENST00000528170.1_Silent_p.V127V|MS4A15_ENST00000337911.4_Silent_p.V75V	NM_001098835.1	NP_001092305.1	Q8N5U1	M4A15_HUMAN	membrane-spanning 4-domains, subfamily A, member 15	168						integral to membrane	receptor activity			breast(1)|large_intestine(2)|lung(3)	6						CCCAGGATGTGGACAGGGGCT	0.567000													19	67					0	0	0.000175454	0	0
PLXND1	23129	broad.mit.edu	37	3	129293200	129293200	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:129293200G>A	ENST00000393239.1	-	12	2842	c.2664C>T	c.(2662-2664)tgC>tgT	p.C888C	PLXND1_ENST00000324093.4_Silent_p.C888C			Q9Y4D7	PLXD1_HUMAN	plexin D1	888					axon guidance	integral to membrane|intracellular|plasma membrane			PLXND1/TMCC1(4)	NS(1)|breast(1)|endometrium(4)|kidney(5)|large_intestine(17)|lung(28)|prostate(10)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	72						CGGGGGCGGGGCAGGTGCCAG	0.697000													4	8					0	0	0.00024832	0	0
ZNF704	619279	broad.mit.edu	37	8	81733664	81733664	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:81733664G>A	ENST00000327835.3	-	2	397	c.166C>T	c.(166-168)Ctc>Ttc	p.L56F		NM_001033723.2	NP_001028895.1	Q6ZNC4	ZN704_HUMAN	zinc finger protein 704	56						intracellular	zinc ion binding			lung(9)|skin(1)|upper_aerodigestive_tract(1)	11	all_cancers(3;8.53e-08)|all_epithelial(4;4.59e-10)|Breast(3;2.56e-06)|Lung NSC(7;2.58e-06)|all_lung(9;9.4e-06)		BRCA - Breast invasive adenocarcinoma(6;0.00401)|Epithelial(68;0.00448)|all cancers(69;0.0277)			TGCTCAAGGAGACAGATGGAG	0.453000													26	117					0	0	0.000147802	0	0
MDM1	56890	broad.mit.edu	37	12	68720383	68720383	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:68720383G>A	ENST00000430606.2	-	3	687	c.552C>T	c.(550-552)ttC>ttT	p.F184F	MDM1_ENST00000303145.7_Intron|MDM1_ENST00000411698.2_Intron|MDM1_ENST00000545724.1_Intron|MDM1_ENST00000540418.1_Intron|MDM1_ENST00000393543.3_3'UTR	NM_001205029.1|NM_020128.2	NP_001191958.1|NP_064513.1	Q8TC05	MDM1_HUMAN	Mdm1 nuclear protein homolog (mouse)	0						nucleus				breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(7)	33			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		AAATGACAATGAAACCAATGA	0.313000													16	49					0	0	0.000308642	0	0
TONSL	4796	broad.mit.edu	37	8	145659413	145659413	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:145659413G>T	ENST00000409379.3	-	21	3364	c.3335C>A	c.(3334-3336)cCc>cAc	p.P1112H		NM_013432.4	NP_038460.4	Q96HA7	TONSL_HUMAN	tonsoku-like, DNA repair protein	1112					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity			biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|lung(14)|ovary(3)|prostate(1)|skin(1)	26						CAGGCCTTCGGGACCCAGGTG	0.662000													10	35					6.40141e-05	0.00164185	6.40141e-05	1	0
LRRC56	115399	broad.mit.edu	37	11	554044	554044	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:554044C>T	ENST00000270115.7	+	14	1897	c.1397C>T	c.(1396-1398)cCg>cTg	p.P466L		NM_198075.3	NP_932341.1	Q8IYG6	LRC56_HUMAN	leucine rich repeat containing 56	466										kidney(1)|lung(4)|skin(1)	6		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGCAGCTCCCCGCGGTGGTCG	0.677000													13	39					0	0	5.01169e-05	0	0
FBXO32	114907	broad.mit.edu	37	8	124518738	124518738	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:124518738C>T	ENST00000517956.1	-	7	919	c.728G>A	c.(727-729)gGg>gAg	p.G243E	FBXO32_ENST00000443022.2_Missense_Mutation_p.G150E	NM_058229.3|NM_148177.2	NP_478136.1|NP_680482.1	Q969P5	FBX32_HUMAN	F-box protein 32	243	F-box.									autonomic_ganglia(1)|breast(3)|endometrium(2)|large_intestine(5)|lung(6)|skin(3)|stomach(1)	21	Lung NSC(37;1.13e-13)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			CAGGTCCCGCCCGTCGCTCAG	0.602000													23	33					0	0	9.22233e-05	0	0
LRRK2	120892	broad.mit.edu	37	12	40704267	40704267	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:40704267G>A	ENST00000298910.7	+	31	4410	c.4352G>A	c.(4351-4353)gGc>gAc	p.G1451D		NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1451	Roc.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				ATTCTCGTTGGCACACATTTG	0.488000													4	15					0	0	1.23904e-05	0	0
NCSTN	23385	broad.mit.edu	37	1	160321843	160321843	+	Splice_Site	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:160321843G>A	ENST00000368063.1	+	9	1063		c.e9-1		NCSTN_ENST00000392212.4_Splice_Site|NCSTN_ENST00000294785.5_Splice_Site|NCSTN_ENST00000535857.1_Intron|NCSTN_ENST00000368065.4_Splice_Site|NCSTN_ENST00000459963.1_Splice_Site			Q92542	NICA_HUMAN	nicastrin						amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane|melanosome	protein binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(2)	34	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GTTGTACCTAGCTGGATAGTC	0.488000													29	58					0	0	0.000339439	0	0
PRM2	5620	broad.mit.edu	37	16	11369729	11369729	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr16:11369729C>T	ENST00000435245.2	-	2	490	c.381G>A	c.(379-381)tgG>tgA	p.W127*	PRM2_ENST00000241808.4_3'UTR|RMI2_ENST00000572173.1_Intron			P04554	PRM2_HUMAN	protamine 2	0					chromosome condensation|multicellular organismal development	nucleoplasm|nucleosome	DNA binding	p.0?(1)		central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(2)	7						TTCTTAATTTCCAGCTGGGGG	0.512000													11	75					0	0	6.40141e-05	0	0
SYCP1	6847	broad.mit.edu	37	1	115401176	115401176	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:115401176G>A	ENST00000369522.3	+	6	540	c.300G>A	c.(298-300)gaG>gaA	p.E100E	SYCP1_ENST00000369518.1_Silent_p.E100E	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	100	Asp/Glu-rich (acidic).				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGAATTCAGAGGGATTGAGCA	0.299000													8	108					0	0	3.86212e-05	0	0
GSG1	83445	broad.mit.edu	37	12	13240172	13240172	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:13240172C>T	ENST00000337630.6	-	5	619	c.552G>A	c.(550-552)atG>atA	p.M184I	GSG1_ENST00000396302.3_Missense_Mutation_p.D226N|GSG1_ENST00000457134.2_Missense_Mutation_p.M133I|GSG1_ENST00000351606.6_Missense_Mutation_p.D262N|GSG1_ENST00000537302.1_Missense_Mutation_p.M156I|GSG1_ENST00000324458.8_Missense_Mutation_p.M220I|GSG1_ENST00000432710.2_Missense_Mutation_p.M197I|GSG1_ENST00000396310.2_Missense_Mutation_p.M153I	NM_153823.3	NP_722545.2	Q2KHT4	GSG1_HUMAN	germ cell associated 1	207						endoplasmic reticulum membrane|integral to membrane				endometrium(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(1)	10		Prostate(47;0.183)		BRCA - Breast invasive adenocarcinoma(232;0.15)		GTGAATACATCATGTGGGCCA	0.498000													5	37					0	0	3.59834e-05	0	0
SUCO	51430	broad.mit.edu	37	1	172571886	172571886	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:172571886C>A	ENST00000367723.3	+	21	3804	c.3680C>A	c.(3679-3681)cCa>cAa	p.P1227Q	SUCO_ENST00000263688.3_Missense_Mutation_p.P1075Q|SUCO_ENST00000486569.1_3'UTR	NM_016227.2	NP_057311.2			SUN domain containing ossification factor																		ACTTCATTCCCACTCATGAGA	0.323000													9	286					0.00010058	0.0025633	0.00010058	1	0
PTPRS	5802	broad.mit.edu	37	19	5212148	5212148	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:5212148C>T	ENST00000372412.4	-	32	5119	c.4886G>A	c.(4885-4887)cGc>cAc	p.R1629H	PTPRS_ENST00000353284.2_Missense_Mutation_p.R1181H|PTPRS_ENST00000587303.1_Missense_Mutation_p.R1628H|PTPRS_ENST00000588012.1_Missense_Mutation_p.R1590H|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000592099.1_Missense_Mutation_p.R1181H|PTPRS_ENST00000262963.6_Missense_Mutation_p.R1608H|PTPRS_ENST00000357368.4_Missense_Mutation_p.R1628H|PTPRS_ENST00000348075.2_Missense_Mutation_p.R1590H			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	1628	Tyrosine-protein phosphatase 1.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		CATGTAGTTGCGCTGGGACCT	0.602000													15	67					0	0	0.000308642	0	0
NCR2	9436	broad.mit.edu	37	6	41304028	41304028	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:41304028G>A	ENST00000373083.4	+	2	478	c.256G>A	c.(256-258)Gac>Aac	p.D86N	NCR2_ENST00000373089.5_Missense_Mutation_p.D86N|NCR2_ENST00000373086.3_Missense_Mutation_p.D86N	NM_001199510.1	NP_001186439.1	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	86	Ig-like.				cellular defense response	integral to plasma membrane	transmembrane receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	14	Ovarian(28;0.0327)|Colorectal(47;0.196)					AATCTGGGACGACCCTGATGC	0.522000													22	40					0	0	0.000295444	0	0
METRNL	284207	broad.mit.edu	37	17	81052056	81052056	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:81052056C>T	ENST00000571814.1	+	3	1367	c.426C>T	c.(424-426)gcC>gcT	p.A142A	METRNL_ENST00000570778.1_Silent_p.A142A|METRNL_ENST00000320095.7_Silent_p.A224A|METRNL_ENST00000571940.1_3'UTR			Q641Q3	METRL_HUMAN	meteorin, glial cell differentiation regulator-like	224						extracellular region				endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	8	Breast(20;0.000443)|all_neural(118;0.0779)		BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			AGGACTCAGCCATCCACCTGC	0.652000													82	73					0	0	0.000147903	0	0
SPAM1	6677	broad.mit.edu	37	7	123594288	123594288	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:123594288C>T	ENST00000340011.5	+	3	1021	c.664C>T	c.(664-666)Ccg>Tcg	p.P222S	SPAM1_ENST00000223028.7_Missense_Mutation_p.P222S|SPAM1_ENST00000460182.1_Missense_Mutation_p.P222S|SPAM1_ENST00000402183.2_Missense_Mutation_p.P222S|SPAM1_ENST00000439500.1_Missense_Mutation_p.P222S	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	222					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	TTATCTTTTTCCGGATTGTTA	0.363000													6	15					0	0	8.12818e-05	0	0
GLI2	2736	broad.mit.edu	37	2	121554883	121554883	+	Translation_Start_Site	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:121554883G>A	ENST00000452319.1	+	0	47				GLI2_ENST00000314490.11_De_novo_Start_OutOfFrame|GLI2_ENST00000435313.2_3'UTR|GLI2_ENST00000361492.4_De_novo_Start_OutOfFrame			P10070	GLI2_HUMAN	GLI family zinc finger 2						axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CACCCAGGACGATGAGCGGCT	0.607000													91	257					0	0	0.000147903	0	0
NCR3	259197	broad.mit.edu	37	6	31557860	31557860	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:31557860G>A	ENST00000376073.4	-	2	350	c.87C>T	c.(85-87)acC>acT	p.T29T	NCR3_ENST00000491161.1_5'UTR|NCR3_ENST00000340027.5_Silent_p.T29T|NCR3_ENST00000376071.4_Silent_p.T29T|NCR3_ENST00000376072.3_Silent_p.T29T	NM_001145466.1	NP_001138938.1	O14931	NCTR3_HUMAN	natural cytotoxicity triggering receptor 3	29	Ig-like.				cell recognition|immune response|inflammatory response|positive regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane	receptor activity			cervix(1)|large_intestine(2)|liver(1)|lung(2)|ovary(1)|skin(2)	9						ATCCTTCCAGGGTACGAATCT	0.577000													28	72					0	0	0.000279167	0	0
F8	2157	broad.mit.edu	37	X	154124378	154124378	+	Nonsense_Mutation	SNP	G	G	A	rs137852356		TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:154124378G>A	ENST00000360256.4	-	22	6603	c.6403C>T	c.(6403-6405)Cga>Tga	p.R2135*		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	2135	F5/8 type C 1.		R -> P (in HEMA; severe).		acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	GAATTTCCTCGATAAGTCTGC	0.408000													27	107					0	0	0.000227799	0	0
ACAA1	30	broad.mit.edu	37	3	38167171	38167171	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:38167171G>A	ENST00000333167.8	-	11	1256	c.1084C>T	c.(1084-1086)Ccc>Tcc	p.P362S	ACAA1_ENST00000480865.1_5'UTR|ACAA1_ENST00000301810.7_Missense_Mutation_p.P269S|ACAA1_ENST00000450296.1_Missense_Mutation_p.P321S	NM_001607.3	NP_001598.1	P09110	THIK_HUMAN	acetyl-CoA acyltransferase 1	362					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy	peroxisomal matrix	acetyl-CoA C-acyltransferase activity|protein binding			endometrium(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)	9				KIRC - Kidney renal clear cell carcinoma(284;0.0523)|Kidney(284;0.0657)		TTCTCAGGGGGGAGTCGTAGC	0.622000													10	22					0	0	2.17888e-05	0	0
GSTP1	2950	broad.mit.edu	37	11	67353993	67353993	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:67353993T>C	ENST00000398606.3	+	7	827	c.578T>C	c.(577-579)tTc>tCc	p.F193S	GSTP1_ENST00000398603.1_Missense_Mutation_p.F157S|GSTP1_ENST00000498765.1_3'UTR	NM_000852.3	NP_000843.1	P09211	GSTP1_HUMAN	glutathione S-transferase pi 1	193	GST C-terminal.				anti-apoptosis|cellular response to lipopolysaccharide|central nervous system development|common myeloid progenitor cell proliferation|glutathione metabolic process|negative regulation of acute inflammatory response|negative regulation of ERK1 and ERK2 cascade|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 beta production|negative regulation of JUN kinase activity|negative regulation of leukocyte proliferation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of necrotic cell death|negative regulation of nitric-oxide synthase 2 biosynthetic process|negative regulation of stress-activated MAPK cascade|negative regulation of tumor necrosis factor production|nitric oxide storage|positive regulation of superoxide anion generation|response to reactive oxygen species|xenobiotic metabolic process	cytosol|protein complex	dinitrosyl-iron complex binding|glutathione transferase activity|JUN kinase binding|kinase regulator activity|nitric oxide binding|S-nitrosoglutathione binding			central_nervous_system(1)|cervix(1)|endometrium(4)|lung(2)|ovary(1)	9					Ethacrynic acid(DB00903)|Glutathione(DB00143)	CTCAAGGCCTTCCTGGCCTCC	0.622000													13	21					0	0	0.000219431	0	0
FLG	2312	broad.mit.edu	37	1	152279024	152279024	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:152279024G>A	ENST00000368799.1	-	3	8373	c.8338C>T	c.(8338-8340)Caa>Taa	p.Q2780*	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2780	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACCGTCTTGGGATGCTGAG	0.597000									Ichthyosis				94	518					0	0	0.000147903	0	0
ARMC6	93436	broad.mit.edu	37	19	19162883	19162883	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:19162883G>A	ENST00000535612.1	+	5	1164	c.732G>A	c.(730-732)tgG>tgA	p.W244*	ARMC6_ENST00000546344.1_Nonsense_Mutation_p.W151*|ARMC6_ENST00000392335.2_Nonsense_Mutation_p.W219*|ARMC6_ENST00000392336.3_Nonsense_Mutation_p.W244*|ARMC6_ENST00000269932.6_Nonsense_Mutation_p.W219*	NM_001199196.1	NP_001186125.1	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	244							protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(5)|ovary(1)|prostate(1)	14			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			AAGCCTGCTGGGCCCTGCGTG	0.577000													6	37					0	0	3.59834e-05	0	0
KCNH5	27133	broad.mit.edu	37	14	63473091	63473091	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:63473091C>T	ENST00000322893.7	-	3	565	c.297G>A	c.(295-297)aaG>aaA	p.K99K	KCNH5_ENST00000420622.2_Silent_p.K99K|KCNH5_ENST00000394968.1_Silent_p.K41K|KCNH5_ENST00000394964.2_Silent_p.K41K	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	99	PAC.				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity	p.K99N(1)		NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TACTGTTTTTCTTGTACAGAA	0.338000													5	13					0	0	8.12818e-05	0	0
ZFP42	132625	broad.mit.edu	37	4	188924832	188924832	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:188924832A>G	ENST00000326866.4	+	4	1279	c.871A>G	c.(871-873)Aac>Gac	p.N291D	ZFP42_ENST00000509524.1_Missense_Mutation_p.N291D	NM_174900.3	NP_777560.2	Q96MM3	ZFP42_HUMAN	ZFP42 zinc finger protein	291					female gonad development|male gonad development|meiosis	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(14;6.2e-52)|all_epithelial(14;7.36e-37)|all_lung(41;2.29e-15)|Lung NSC(41;6.7e-15)|Breast(6;1.53e-05)|Melanoma(20;3.01e-05)|Hepatocellular(41;0.00335)|all_hematologic(60;0.014)|Renal(120;0.0183)|Prostate(90;0.0421)|Colorectal(36;0.227)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;4.21e-06)|GBM - Glioblastoma multiforme(59;8.93e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.157)		TCAGTCAAATAACCTGAAAGC	0.458000													31	80					0	0	0.000191422	0	0
COL4A1	1282	broad.mit.edu	37	13	110838777	110838777	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr13:110838777C>T	ENST00000375820.4	-	26	1973	c.1852G>A	c.(1852-1854)Gga>Aga	p.G618R		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	618	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CCTGCTTGTCCTTTGTCACCA	0.617000													19	90					0	0	7.07596e-05	0	0
UPK3B	80761	broad.mit.edu	37	7	76144448	76144448	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:76144448C>T	ENST00000443097.2	+	6	983	c.758C>T	c.(757-759)cCa>cTa	p.P253L	UPK3B_ENST00000394849.1_Silent_p.P226P|UPK3B_ENST00000257632.5_Silent_p.P281P|UPK3B_ENST00000448265.3_Silent_p.P281P|UPK3B_ENST00000419923.2_Silent_p.P281P|UPK3B_ENST00000334348.3_Missense_Mutation_p.P253L			Q9BT76	UPK3B_HUMAN	uroplakin 3B	0					negative regulation of gene expression	integral to membrane|plasma membrane				breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(1)|lung(1)|skin(2)	8		Myeloproliferative disorder(862;0.204)				CACCACATCCCACCCAGAGAG	0.706000													6	6					0	0	8.12818e-05	0	0
HRH1	3269	broad.mit.edu	37	3	11301470	11301470	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:11301470G>A	ENST00000397056.1	+	3	938	c.747G>A	c.(745-747)aaG>aaA	p.K249K	HRH1_ENST00000431010.2_Silent_p.K249K|HRH1_ENST00000438284.2_Silent_p.K249K	NM_000861.3|NM_001098211.1	NP_000852.1|NP_001091681.1	P35367	HRH1_HUMAN	histamine receptor H1	249					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|inflammatory response	cytoplasm|integral to plasma membrane|nucleus	histamine receptor activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25					Aceprometazine(DB01615)|Astemizole(DB00637)|Azatadine(DB00719)|Azelastine(DB00972)|Benzquinamide(DB00767)|Bepotastine(DB04890)|Bromodiphenhydramine(DB01237)|Brompheniramine(DB00835)|Buclizine(DB00354)|Carbinoxamine(DB00748)|Cetirizine(DB00341)|Chlophedianol(DB04837)|Chlorpheniramine(DB01114)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clemastine(DB00283)|Clozapine(DB00363)|Cyclizine(DB01176)|Cyproheptadine(DB00434)|Desipramine(DB01151)|Desloratadine(DB00967)|Dexbrompheniramine(DB00405)|Dimenhydrinate(DB00985)|Diphenhydramine(DB01075)|Diphenylpyraline(DB01146)|Doxepin(DB01142)|Doxylamine(DB00366)|Emedastine(DB01084)|Epinastine(DB00751)|Fexofenadine(DB00950)|Flunarizine(DB04841)|Histamine Phosphate(DB00667)|Hydroxyzine(DB00557)|Ketotifen(DB00920)|Levocabastine(DB01106)|Loratadine(DB00455)|Maprotiline(DB00934)|Meclizine(DB00737)|Mequitazine(DB01071)|Methdilazine(DB00902)|Methotrimeprazine(DB01403)|Mianserin(DB06148)|Mirtazapine(DB00370)|Nedocromil(DB00716)|Olanzapine(DB00334)|Olopatadine(DB00768)|Orphenadrine(DB01173)|Pemirolast(DB00885)|Phenindamine(DB01619)|Pheniramine(DB01620)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Terfenadine(DB00342)|Thiethylperazine(DB00372)|Trazodone(DB00656)|Trimeprazine(DB01246)|Tripelennamine(DB00792)|Triprolidine(DB00427)|Ziprasidone(DB00246)	GGGATGCCAAGAAACCAGGGA	0.542000													7	21					0	0	0.000157383	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51920407	51920407	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:51920407A>G	ENST00000353836.5	-	2	571	c.350T>C	c.(349-351)tTc>tCc	p.F117S	SIGLEC10_ENST00000339313.5_Missense_Mutation_p.F117S|SIGLEC10_ENST00000525998.1_Missense_Mutation_p.F117S|SIGLEC10_ENST00000436984.2_Missense_Mutation_p.F117S|SIGLEC10_ENST00000439889.2_Missense_Mutation_p.F117S|SIGLEC10_ENST00000441969.3_Missense_Mutation_p.F117S|SIGLEC10_ENST00000432469.2_Missense_Mutation_p.F117S|CTD-2616J11.2_ENST00000532688.1_RNA|SIGLEC10_ENST00000356298.5_Missense_Mutation_p.F117S|SIGLEC10_ENST00000442846.3_Missense_Mutation_p.F117S	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	117	Ig-like V-type.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		CACCCGAAAGAAGTACTGTGA	0.527000													25	52					0	0	5.49717e-05	0	0
SEPT9	10801	broad.mit.edu	37	17	75398449	75398449	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:75398449C>T	ENST00000329047.8	+	2	1143	c.331C>T	c.(331-333)Cgg>Tgg	p.R111W	SEPT9_ENST00000592420.1_5'UTR|SEPT9_ENST00000588690.1_5'UTR|SEPT9_ENST00000591198.1_Missense_Mutation_p.R110W|SEPT9_ENST00000449803.2_5'UTR|SEPT9_ENST00000427674.2_5'UTR|SEPT9_ENST00000590294.1_Missense_Mutation_p.R111W|SEPT9_ENST00000423034.2_Missense_Mutation_p.R122W|SEPT9_ENST00000431235.2_5'UTR|SEPT9_ENST00000427177.1_Missense_Mutation_p.R129W	NM_006640.4	NP_006631.2	Q9UHD8	SEPT9_HUMAN	septin 9	129			S -> F (in HNA).		cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)	16			BRCA - Breast invasive adenocarcinoma(99;0.153)			CGGCCCGTCCCGGTTCGGGCT	0.682000													26	15					0	0	0.000227799	0	0
PSG5	5673	broad.mit.edu	37	19	43680036	43680036	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:43680036G>A	ENST00000404580.1	-	3	783	c.695C>T	c.(694-696)aCc>aTc	p.T232I	PSG5_ENST00000407356.1_Missense_Mutation_p.T232I|PSG5_ENST00000366175.3_Missense_Mutation_p.T232I|PSG5_ENST00000407568.1_Intron|PSG5_ENST00000599812.1_Missense_Mutation_p.T325I|PSG5_ENST00000342951.6_Missense_Mutation_p.T232I			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	232	Ig-like C2-type 1.			T -> S (in Ref. 2; AAA60205 and 3; AAA36514).	female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				GACATTCAGGGTGACTGGGTC	0.498000													11	30					0	0	3.86212e-05	0	0
PLEC	5339	broad.mit.edu	37	8	144995805	144995805	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:144995805G>A	ENST00000322810.4	-	32	8764	c.8595C>T	c.(8593-8595)atC>atT	p.I2865I	PLEC_ENST00000356346.3_Silent_p.I2714I|PLEC_ENST00000357649.2_Silent_p.I2732I|PLEC_ENST00000398774.2_Silent_p.I2696I|PLEC_ENST00000436759.2_Silent_p.I2755I|PLEC_ENST00000354958.2_Silent_p.I2706I|PLEC_ENST00000345136.3_Silent_p.I2728I|PLEC_ENST00000527096.1_Silent_p.I2751I|PLEC_ENST00000354589.3_Silent_p.I2728I	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	2865	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CCTCCAGCAGGATGAGGGCCG	0.667000													14	37					0	0	0.000308642	0	0
MIR329-2	574409	broad.mit.edu	37	14	101493486	101493486	+	RNA	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:101493486G>A	ENST00000385029.1	+	0	50					NR_029968.1																						TATTGAGGACGAAACACACCT	0.458000													85	117					0	0	0.000147903	0	0
FAAH2	158584	broad.mit.edu	37	X	57475082	57475082	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:57475082C>T	ENST00000374900.4	+	10	1474	c.1354C>T	c.(1354-1356)Ccc>Tcc	p.P452S	FAAH2_ENST00000491179.1_Intron	NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	452						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						GTTCTTATATCCCTCACATCC	0.423000										HNSCC(52;0.14)			4	17					0	0	0.00024832	0	0
OR10J3	441911	broad.mit.edu	37	1	159283990	159283990	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:159283990G>A	ENST00000332217.5	-	1	459	c.460C>T	c.(460-462)Ctt>Ttt	p.L154F		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	154					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					GCCATGCCAAGGCCAATCCCC	0.507000													4	2					0	0	1.23904e-05	0	0
ZZEF1	23140	broad.mit.edu	37	17	3954306	3954306	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:3954306G>A	ENST00000381638.2	-	36	5756	c.5632C>T	c.(5632-5634)Cca>Tca	p.P1878S		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	1878							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						GTTACCATTGGGTGGGCCGTG	0.517000													14	101					0	0	0.000422831	0	0
LRRC49	54839	broad.mit.edu	37	15	71305224	71305224	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr15:71305224C>T	ENST00000260382.5	+	14	1935	c.1675C>T	c.(1675-1677)Cgt>Tgt	p.R559C	LRRC49_ENST00000560158.2_Missense_Mutation_p.R247C|LRRC49_ENST00000443425.2_Missense_Mutation_p.R515C|LRRC49_ENST00000560369.1_Missense_Mutation_p.R564C|LRRC49_ENST00000544974.2_Missense_Mutation_p.R549C|LRRC49_ENST00000436542.2_3'UTR|LRRC49_ENST00000560691.1_Missense_Mutation_p.R265C	NM_001199017.1|NM_017691.3	NP_001185946.1|NP_060161.2	Q8IUZ0	LRC49_HUMAN	leucine rich repeat containing 49	559						cytoplasm|microtubule				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(3)|skin(3)	34						ACCCCAGTATCGTCTGATTTC	0.363000													13	21					0	0	0.000151284	0	0
FLG	2312	broad.mit.edu	37	1	152285304	152285304	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:152285304C>T	ENST00000368799.1	-	3	2093	c.2058G>A	c.(2056-2058)caG>caA	p.Q686Q	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	686	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TAGAGGAATTCTGTGTGTGAC	0.552000									Ichthyosis				100	299					0	0	0.000147903	0	0
TMEM56	148534	broad.mit.edu	37	1	95616880	95616880	+	Splice_Site	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:95616880G>A	ENST00000370203.4	+	5	595		c.e5-1		RP11-57H12.6_ENST00000604534.1_Splice_Site	NM_001199679.1|NM_152487.2	NP_001186608.1|NP_689700.1	Q96MV1	TMM56_HUMAN	transmembrane protein 56							integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)|skin(1)|urinary_tract(1)	12		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.133)		CTTTCTTACAGATTTGTCCAT	0.348000													7	13					0	0	0.000157383	0	0
LRRC46	90506	broad.mit.edu	37	17	45913763	45913763	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:45913763T>C	ENST00000269025.4	+	7	880	c.517T>C	c.(517-519)Tgg>Cgg	p.W173R		NM_033413.3	NP_219481.1	Q96FV0	LRC46_HUMAN	leucine rich repeat containing 46	173	LRRCT.									endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)	9						GGTGGAGCGCTGGATTTCGGA	0.592000													28	22					0	0	0.000279167	0	0
DOCK11	139818	broad.mit.edu	37	X	117749610	117749610	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:117749610C>T	ENST00000276204.6	+	30	3302	c.3228C>T	c.(3226-3228)caC>caT	p.H1076H	DOCK11_ENST00000276202.7_Silent_p.H1076H			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	1076					blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						TTTGCAATCACGAACATTACA	0.353000													9	16					0	0	6.40141e-05	0	0
ABCB8	11194	broad.mit.edu	37	7	150730720	150730720	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:150730720C>T	ENST00000358849.4	+	2	217	c.124C>T	c.(124-126)Ctc>Ttc	p.L42F	ABCB8_ENST00000477719.1_Missense_Mutation_p.L42F|ABCB8_ENST00000356058.4_Missense_Mutation_p.L79F|ABCB8_ENST00000498578.1_Missense_Mutation_p.L42F|ABCB8_ENST00000477092.1_Missense_Mutation_p.L42F|ABCB8_ENST00000493338.1_3'UTR|ABCB8_ENST00000297504.6_Missense_Mutation_p.L59F|ABCB8_ENST00000542328.1_Intron	NM_007188.3	NP_009119.2	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 8	59						ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	26			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CAGCTCCTCCCTCCTCCGGGC	0.677000													29	61					0	0	0.000191422	0	0
CPT1C	126129	broad.mit.edu	37	19	50200690	50200690	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:50200690G>A	ENST00000392518.4	+	4	621	c.249G>A	c.(247-249)ctG>ctA	p.L83L	CPT1C_ENST00000405931.2_Silent_p.L83L|CPT1C_ENST00000323446.5_Silent_p.L83L|CPT1C_ENST00000598293.1_Silent_p.L83L|CPT1C_ENST00000354199.5_Silent_p.L83L	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C	83					fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		CCTTAGGACTGATGGAGAAGA	0.557000													19	89					0	0	0.000295444	0	0
RGP1	9827	broad.mit.edu	37	9	35749253	35749253	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr9:35749253G>A	ENST00000456972.2	+	1	51	c.51G>A	c.(49-51)agG>agA	p.R17R	GBA2_ENST00000545786.1_Intron			Q92546	RGP1_HUMAN	RGP1 retrograde golgi transport homolog (S. cerevisiae)	0										cervix(1)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	14	all_epithelial(49;0.167)		Lung(28;0.00416)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CGGCCGGAAGGGACTCCGCGG	0.771000													3	6					0	0	0.00024832	0	0
UBR2	23304	broad.mit.edu	37	6	42585058	42585058	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:42585058C>T	ENST00000372899.1	+	11	1521	c.1263C>T	c.(1261-1263)ttC>ttT	p.F421F	UBR2_ENST00000372901.1_Intron|UBR2_ENST00000372903.2_Intron|UBR2_ENST00000372883.3_Intron	NM_015255.2	NP_056070.1	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	421					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			CTGTCCAGTTCTTCACCGCAC	0.458000													11	26					0	0	6.40141e-05	0	0
KCNB2	9312	broad.mit.edu	37	8	73849751	73849751	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:73849751G>A	ENST00000523207.1	+	3	2749	c.2161G>A	c.(2161-2163)Gaa>Aaa	p.E721K		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	721					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			GAACTTTAAGGAAAATAGAGG	0.527000													6	60					0	0	8.12818e-05	0	0
EVC2	132884	broad.mit.edu	37	4	5564588	5564588	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:5564588A>T	ENST00000310917.2	-	22	4405	c.3674T>A	c.(3673-3675)tTg>tAg	p.L1225*	EVC2_ENST00000344408.5_Nonsense_Mutation_p.L1305*|EVC2_ENST00000344938.1_Intron	NM_001166136.1	NP_001159608.1	Q86UK5	LBN_HUMAN	Ellis van Creveld syndrome 2	1305						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						GTCCATGCCCAAGGCCCTCAT	0.478000													28	72					0	0	0.000279167	0	0
RASSF9	9182	broad.mit.edu	37	12	86198613	86198613	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:86198613C>T	ENST00000361228.3	-	2	1543	c.1175G>A	c.(1174-1176)gGg>gAg	p.G392E		NM_005447.3	NP_005438.2	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	392					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AGGAATCTCCCCATTGCTACT	0.443000													37	135					0	0	0.000270559	0	0
HMGCR	3156	broad.mit.edu	37	5	74638497	74638497	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr5:74638497G>T	ENST00000287936.4	+	2	223	c.67G>T	c.(67-69)Ggg>Tgg	p.G23W	HMGCR_ENST00000511206.1_Missense_Mutation_p.G23W|HMGCR_ENST00000343975.5_Missense_Mutation_p.G23W	NM_000859.2	NP_000850.1	P04035	HMDH_HUMAN	3-hydroxy-3-methylglutaryl-CoA reductase	23					cholesterol biosynthetic process|coenzyme A metabolic process|germ cell migration|gonad development|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal membrane	hydroxymethylglutaryl-CoA reductase (NADPH) activity|NADP binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	20		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;2.24e-54)	Atorvastatin(DB01076)|Bezafibrate(DB01393)|Cerivastatin(DB00439)|Fluvastatin(DB01095)|Lovastatin(DB00227)|NADH(DB00157)|Pravastatin(DB00175)|Rosuvastatin(DB01098)|Simvastatin(DB00641)	AGTCATAGTGGGGACAGTGAC	0.438000													15	608					9.7654e-05	0.00249932	9.7654e-05	1	0
CNTNAP5	129684	broad.mit.edu	37	2	125262126	125262126	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:125262126C>T	ENST00000431078.1	+	8	1681	c.1317C>T	c.(1315-1317)atC>atT	p.I439I		NM_130773.2	NP_570129.1	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5	439	Laminin G-like 2.				cell adhesion|signal transduction	integral to membrane	receptor binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(24)|lung(100)|ovary(10)|prostate(12)|skin(4)|upper_aerodigestive_tract(3)	176				BRCA - Breast invasive adenocarcinoma(221;0.248)		TAGCTGAAATCCTCACAGGTA	0.498000													3	5					0	0	0.00024832	0	0
FUT5	2527	broad.mit.edu	37	19	5867530	5867530	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:5867530C>T	ENST00000252675.5	-	5	769	c.207G>A	c.(205-207)gcG>gcA	p.A69A	FUT5_ENST00000588525.1_Silent_p.A69A			Q11128	FUT5_HUMAN	fucosyltransferase 5 (alpha (1,3) fucosyltransferase)	69					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12						GGGCAGGGGTCGCCATGCTGT	0.667000													10	43					0	0	0.000151284	0	0
AHNAK2	113146	broad.mit.edu	37	14	105418710	105418710	+	Silent	SNP	G	G	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:105418710G>T	ENST00000333244.5	-	7	3197	c.3078C>A	c.(3076-3078)ccC>ccA	p.P1026P	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	1026						nucleus		p.P1026P(1)		cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCTCCACCTTGGGTGCAGACA	0.577000													12	247					0.00010058	0.0025633	0.00010058	1	0
TACC2	10579	broad.mit.edu	37	10	123842478	123842478	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:123842478C>T	ENST00000369005.1	+	4	803	c.463C>T	c.(463-465)Ccc>Tcc	p.P155S	TACC2_ENST00000513429.1_Intron|TACC2_ENST00000515603.1_Missense_Mutation_p.P155S|TACC2_ENST00000453444.2_Missense_Mutation_p.P155S|TACC2_ENST00000515273.1_Missense_Mutation_p.P155S|TACC2_ENST00000334433.3_Missense_Mutation_p.P155S|TACC2_ENST00000358010.1_Intron	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	155						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				GGCGGCATTTCCCGCTGAGAG	0.587000													7	18					0	0	8.12818e-05	0	0
DPP10	57628	broad.mit.edu	37	2	116594278	116594278	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:116594278G>A	ENST00000410059.1	+	24	2618	c.2138G>A	c.(2137-2139)gGc>gAc	p.G713D	DPP10_ENST00000393147.2_Missense_Mutation_p.G717D|DPP10_ENST00000409163.1_Missense_Mutation_p.G663D|DPP10_ENST00000310323.8_Missense_Mutation_p.G706D	NM_001178037.1|NM_020868.3	NP_001171508.1|NP_065919.2	Q8N608	DPP10_HUMAN	dipeptidyl-peptidase 10 (non-functional)	713					proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(24)|liver(2)|lung(48)|ovary(6)|prostate(1)|skin(5)|soft_tissue(1)	101						AATGTTCATGGCTTGAAAGAA	0.313000													79	181					0	0	0.000147903	0	0
MOV10L1	54456	broad.mit.edu	37	22	50598106	50598106	+	Splice_Site	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr22:50598106G>A	ENST00000262794.5	+	24	3299		c.e24-1		MOV10L1_ENST00000395858.3_Splice_Site|MOV10L1_ENST00000395852.1_Splice_Site|MOV10L1_ENST00000545383.1_Splice_Site|MOV10L1_ENST00000540615.1_Splice_Site	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)						germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		CTGTTCTCAAGGTGGAGAAAA	0.343000													15	48					0	0	0.000308642	0	0
TP53I13	90313	broad.mit.edu	37	17	27899038	27899038	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:27899038C>T	ENST00000301057.7	+	5	591	c.476C>T	c.(475-477)cCc>cTc	p.P159L	RP11-68I3.2_ENST00000581474.1_RNA	NM_138349.2	NP_612358.3	Q8NBR0	P5I13_HUMAN	tumor protein p53 inducible protein 13	159						cytoplasm|integral to membrane|plasma membrane				NS(1)|kidney(1)|lung(1)|urinary_tract(1)	4				READ - Rectum adenocarcinoma(3;0.236)		GAGCCAACTCCCGGTAGAGGG	0.622000													28	23					0	0	0.000227799	0	0
SART1	9092	broad.mit.edu	37	11	65734802	65734802	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:65734802G>A	ENST00000312397.5	+	10	1353	c.1261G>A	c.(1261-1263)Gat>Aat	p.D421N		NM_005146.4	NP_005137.1	O43290	SNUT1_HUMAN	squamous cell carcinoma antigen recognized by T cells	421					cell cycle arrest|induction of apoptosis by intracellular signals|positive regulation of cytotoxic T cell differentiation|spliceosomal snRNP assembly	Cajal body|catalytic step 2 spliceosome|cytosol				endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						AGTGCGGGCAGATGACTTGCT	0.587000													29	121					0	0	0.000279167	0	0
MORC1	27136	broad.mit.edu	37	3	108723946	108723946	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:108723946C>T	ENST00000232603.5	-	19	2066	c.1984G>A	c.(1984-1986)Gaa>Aaa	p.E662K	MORC1_ENST00000483760.1_Missense_Mutation_p.E641K	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	662					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TTGACATTTTCTGGCAGAGCT	0.348000													37	49					0	0	0.000319135	0	0
GTPBP2	54676	broad.mit.edu	37	6	43592393	43592393	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:43592393G>A	ENST00000307126.5	-	7	953	c.954C>T	c.(952-954)atC>atT	p.I318I	GTPBP2_ENST00000307114.7_Silent_p.I230I|GTPBP2_ENST00000476510.1_5'UTR	NM_019096.3	NP_061969.3	Q9BX10	GTPB2_HUMAN	GTP binding protein 2	318							GTP binding|GTPase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(3)|prostate(1)|skin(2)|urinary_tract(1)	18	all_cancers(18;9.36e-06)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000501)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			CACATAGGTCGATCTTGCTGA	0.602000													11	71					0	0	6.40141e-05	0	0
C10orf137	26098	broad.mit.edu	37	10	127436243	127436243	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:127436243T>A	ENST00000337623.3	+	19	2956	c.2851T>A	c.(2851-2853)Tct>Act	p.S951T	C10orf137_ENST00000356792.4_Missense_Mutation_p.S985T|RP11-383C5.7_ENST00000593871.1_RNA|RP11-383C5.7_ENST00000602030.1_RNA|RP11-383C5.7_ENST00000449436.1_RNA|RP11-383C5.7_ENST00000594025.1_RNA|RP11-383C5.7_ENST00000600784.1_RNA	NM_015608.2	NP_056423.2	Q3B7T1	EDRF1_HUMAN	chromosome 10 open reading frame 137	985					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(20)|ovary(8)|pancreas(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(4)	61		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				TGCTCCGTTATCTAGAAAAGC	0.378000													4	17					0	0	0.00024832	0	0
BCL11A	53335	broad.mit.edu	37	2	60773237	60773237	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:60773237G>T	ENST00000335712.6	-	2	481	c.254C>A	c.(253-255)cCt>cAt	p.P85H	BCL11A_ENST00000537768.1_5'UTR|BCL11A_ENST00000356842.4_Missense_Mutation_p.P85H|BCL11A_ENST00000538214.1_Missense_Mutation_p.P85H|BCL11A_ENST00000358510.4_Missense_Mutation_p.P85H|BCL11A_ENST00000359629.5_Missense_Mutation_p.P85H	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	85	Required for nuclear body formation and for SUMO1 recruitment (By similarity).				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TGAAGGGGAAGGTGGCTTATC	0.463000			T	IGH@	B-CLL								232	508					1.85892e-132	4.84002e-131	0.000147903	1	0
RP11-407N17.3	0	broad.mit.edu	37	14	39703424	39703424	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:39703424G>A	ENST00000553728.1	+	1	319	c.106G>A	c.(106-108)Gaa>Aaa	p.E36K	MIA2_ENST00000556784.1_Missense_Mutation_p.E36K|MIA2_ENST00000280082.3_Missense_Mutation_p.E36K																							TGGTGACTTGGAATGTGAAGG	0.408000													6	7					0	0	3.59834e-05	0	0
FAM166A	401565	broad.mit.edu	37	9	140140000	140140000	+	Missense_Mutation	SNP	G	G	A	rs77069806	by1000genomes	TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr9:140140000G>A	ENST00000344774.4	-	3	335	c.281C>T	c.(280-282)cCc>cTc	p.P94L	FAM166A_ENST00000388932.2_Missense_Mutation_p.P94L	NM_001001710.1	NP_001001710.1	Q6J272	F166A_HUMAN	family with sequence similarity 166, member A	94										kidney(3)|lung(7)|ovary(2)|prostate(1)|urinary_tract(2)	15						GTTCTTAGAGGGCTTCAGACC	0.622000													8	58					0	0	3.86212e-05	0	0
NALCN	259232	broad.mit.edu	37	13	101762990	101762990	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr13:101762990G>A	ENST00000251127.6	-	20	2425	c.2344C>T	c.(2344-2346)Ctt>Ttt	p.L782F		NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	782						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					AAAGTTTCAAGAGATTTTCCC	0.383000													5	3					0	0	8.12818e-05	0	0
ABCC10	89845	broad.mit.edu	37	6	43400805	43400805	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:43400805C>T	ENST00000244533.3	+	1	1317	c.958C>T	c.(958-960)Ctg>Ttg	p.L320L	ABCC10_ENST00000372530.4_Silent_p.L363L|ABCC10_ENST00000443426.2_Intron	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	363	ABC transmembrane type-1 1.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GCTGAACATCCTGTACTGCAA	0.577000													35	61					0	0	8.91981e-05	0	0
ABCC4	10257	broad.mit.edu	37	13	95858979	95858979	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr13:95858979G>A	ENST00000376887.4	-	8	1082	c.968C>T	c.(967-969)tCa>tTa	p.S323L	ABCC4_ENST00000536256.1_Missense_Mutation_p.S248L|ABCC4_ENST00000538287.1_3'UTR|ABCC4_ENST00000412704.1_Missense_Mutation_p.S323L|ABCC4_ENST00000431522.1_Missense_Mutation_p.S323L	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	323	ABC transmembrane type-1 1.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	ACTGAAAAATGAAGCCAAATT	0.473000													32	110					0	0	0.000191422	0	0
SPATA8	145946	broad.mit.edu	37	15	97328286	97328286	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr15:97328286C>T	ENST00000328504.3	+	3	524	c.257C>T	c.(256-258)tCc>tTc	p.S86F	SPATA8_ENST00000558553.1_Silent_p.F45F	NM_173499.3	NP_775770.1	Q6RVD6	SPAT8_HUMAN	spermatogenesis associated 8	86										large_intestine(4)|lung(8)|ovary(1)|skin(3)	16	Melanoma(26;0.0142)|Lung NSC(78;0.041)|all_lung(78;0.0468)		OV - Ovarian serous cystadenocarcinoma(32;0.0718)			CCATCTGCTTCCCCACTGATT	0.453000													36	99					0	0	0.000132358	0	0
RANGAP1	5905	broad.mit.edu	37	22	41660752	41660752	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr22:41660752G>A	ENST00000455915.2	-	4	1865	c.396C>T	c.(394-396)ttC>ttT	p.F132F	RANGAP1_ENST00000405486.1_Silent_p.F132F|RANGAP1_ENST00000356244.3_Silent_p.F132F|RANGAP1_ENST00000407260.4_Silent_p.F122F			P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	132					mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						GCAGGGCCTCGAAGCCTTGCA	0.617000													9	51					0	0	0.000274275	0	0
TMEM189	387521	broad.mit.edu	37	20	48699408	48699408	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr20:48699408G>A	ENST00000557021.1	-	8	1170	c.1010C>T	c.(1009-1011)tCa>tTa	p.S337L	UBE2V1_ENST00000371657.5_Missense_Mutation_p.S72L|UBE2V1_ENST00000340309.3_Missense_Mutation_p.S137L|UBE2V1_ENST00000371677.3_Missense_Mutation_p.S137L|UBE2V1_ENST00000371674.3_Missense_Mutation_p.S114L|UBE2V1_ENST00000415862.2_Missense_Mutation_p.S70L|UBE2V1_ENST00000420027.2_Missense_Mutation_p.S70L|UBE2V1_ENST00000396059.3_5'UTR|TMEM189-UBE2V1_ENST00000341698.2_Missense_Mutation_p.S337L	NM_199203.2	NP_954673.1			transmembrane protein 189											breast(1)|endometrium(2)|large_intestine(3)|lung(2)	8			BRCA - Breast invasive adenocarcinoma(9;3.02e-07)			GATGCTATATGAATTCTGCCA	0.423000													38	124					0	0	0.000132358	0	0
NDST2	8509	broad.mit.edu	37	10	75566505	75566505	+	Silent	SNP	G	G	A	rs35023121	byFrequency	TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:75566505G>A	ENST00000299641.4	-	6	1759	c.789C>T	c.(787-789)ttC>ttT	p.F263F	NDST2_ENST00000309979.6_Silent_p.F386F	NM_003635.3	NP_003626.1	P52849	NDST2_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	386	Heparan sulfate N-deacetylase 2.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	30	Prostate(51;0.0112)					ACATGTGGGGGAACCACCAGA	0.577000													12	32					0	0	0.000151284	0	0
SLC9C1	285335	broad.mit.edu	37	3	111950327	111950327	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:111950327C>T	ENST00000305815.5	-	13	1705	c.1453G>A	c.(1453-1455)Gaa>Aaa	p.E485K	SLC9C1_ENST00000487372.1_Missense_Mutation_p.E437K	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	485					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										GTTTCTTCTTCGTTCAACTAA	0.333000													6	7					0	0	3.59834e-05	0	0
ISM2	145501	broad.mit.edu	37	14	77951247	77951247	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:77951247C>T	ENST00000342219.4	-	2	213	c.157G>A	c.(157-159)Gat>Aat	p.D53N	ISM2_ENST00000393684.3_5'UTR|ISM2_ENST00000429906.1_Intron|ISM2_ENST00000412904.1_Missense_Mutation_p.D53N|ISM2_ENST00000493585.1_Missense_Mutation_p.D53N	NM_199296.2	NP_954993.1	Q6H9L7	ISM2_HUMAN	isthmin 2	53						extracellular region				endometrium(3)|large_intestine(4)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	21						GGCCTAGGATCTGGGGAGGCT	0.607000													39	80					0	0	0.000125731	0	0
HEATR6	63897	broad.mit.edu	37	17	58147098	58147098	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:58147098C>T	ENST00000184956.6	-	7	929	c.913G>A	c.(913-915)Gaa>Aaa	p.E305K	HEATR6_ENST00000585976.1_Missense_Mutation_p.E305K	NM_022070.4	NP_071353.4	Q6AI08	HEAT6_HUMAN	HEAT repeat containing 6	305							binding			NS(1)|breast(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	44	all_cancers(5;2.25e-13)|Breast(5;4.84e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		BRCA - Breast invasive adenocarcinoma(1;5.93e-19)|Epithelial(12;7.59e-12)|all cancers(12;1.26e-10)			GCACTGGATTCTGATTGCTGT	0.403000													22	133					0	0	0.000295444	0	0
MXRA5	25878	broad.mit.edu	37	X	3242878	3242878	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:3242878G>A	ENST00000217939.6	-	5	1002	c.848C>T	c.(847-849)cCt>cTt	p.P283L		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	283						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				CTGTCTCAGAGGGGACTCTAT	0.493000													39	80					0	0	0.000147903	0	0
PARP1	142	broad.mit.edu	37	1	226564968	226564968	+	Silent	SNP	C	C	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:226564968C>A	ENST00000366794.5	-	13	1925	c.1782G>T	c.(1780-1782)acG>acT	p.T594T		NM_001618.3	NP_001609.2	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase 1	594					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			breast(2)|endometrium(4)|kidney(4)|large_intestine(8)|lung(15)|ovary(3)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	44	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		TACCGATCACCGTACCCACAC	0.512000								Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA					8	300					0.000274275	0.00696045	0.000274275	1	0
LMTK2	22853	broad.mit.edu	37	7	97822756	97822756	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:97822756C>T	ENST00000297293.5	+	11	3272	c.2979C>T	c.(2977-2979)tcC>tcT	p.S993S		NM_014916.3	NP_055731.2	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2	993					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|pancreas(2)|skin(2)|stomach(3)	59	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					CTGAGCCGTCCCTGGAAACCC	0.587000													58	113					0	0	0.000147903	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858416	9858416	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr16:9858416C>T	ENST00000396573.2	-	14	3294	c.2985G>A	c.(2983-2985)acG>acA	p.T995T	GRIN2A_ENST00000330684.3_Silent_p.T995T|GRIN2A_ENST00000396575.2_Silent_p.T995T|GRIN2A_ENST00000562109.1_Silent_p.T995T|GRIN2A_ENST00000404927.2_Silent_p.T995T|GRIN2A_ENST00000535259.1_Silent_p.T838T	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	995					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CCACCTCCACCGTGTTAGGGT	0.498000													10	26					0	0	2.17888e-05	0	0
XRRA1	143570	broad.mit.edu	37	11	74554479	74554479	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:74554479C>T	ENST00000340360.6	-	19	2476	c.2145G>A	c.(2143-2145)tgG>tgA	p.W715*	XRRA1_ENST00000527087.1_Missense_Mutation_p.G593E|XRRA1_ENST00000321448.8_Nonsense_Mutation_p.W440*	NM_182969.2	NP_892014.1	Q6P2D8	XRRA1_HUMAN	X-ray radiation resistance associated 1	715					response to X-ray	cytoplasm|nucleus				breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(3)	20						GCCGTTCTGTCCACTGGTGCA	0.582000													3	6					0	0	0.00024832	0	0
GYS2	2998	broad.mit.edu	37	12	21690091	21690091	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:21690091G>A	ENST00000261195.2	-	16	2163	c.1909C>T	c.(1909-1911)Ccc>Tcc	p.P637S		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	637					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						GAAGGCCTGGGATATTTAAAT	0.433000													5	13					0	0	8.12818e-05	0	0
SPTBN5	51332	broad.mit.edu	37	15	42145866	42145866	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr15:42145866G>A	ENST00000320955.6	-	58	10121	c.9894C>T	c.(9892-9894)acC>acT	p.T3298T		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	3298					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		TCGCCTGCAGGGTGGCCCAGG	0.697000													5	31					0	0	0.000157383	0	0
MFAP1	4236	broad.mit.edu	37	15	44107265	44107265	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr15:44107265G>A	ENST00000267812.3	-	3	539	c.307C>T	c.(307-309)Cga>Tga	p.R103*		NM_005926.2	NP_005917.2	P55081	MFAP1_HUMAN	microfibrillar-associated protein 1	103						microfibril				breast(2)|endometrium(1)|kidney(1)|lung(6)|skin(2)|upper_aerodigestive_tract(3)	15		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		TTTCGATGTCGAGCCAATCTG	0.423000													17	39					0	0	7.07596e-05	0	0
EN2	2020	broad.mit.edu	37	7	155255095	155255095	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:155255095A>G	ENST00000297375.4	+	2	964	c.715A>G	c.(715-717)Aac>Gac	p.N239D		NM_001427.3	NP_001418.2	P19622	HME2_HUMAN	engrailed homeobox 2	239						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(1)|lung(2)	4	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AAAGAAGAAGAACCCGAACAA	0.582000													9	82					0	0	0.000274275	0	0
KIAA1549	57670	broad.mit.edu	37	7	138583706	138583706	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:138583706G>A	ENST00000440172.1	-	9	3890	c.3842C>T	c.(3841-3843)gCc>gTc	p.A1281V	KIAA1549_ENST00000242365.4_Missense_Mutation_p.A1231V|KIAA1549_ENST00000422774.1_Missense_Mutation_p.A1281V	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	1281						integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						CTTACGCTGGGCAATGACACC	0.512000			O	BRAF	pilocytic astrocytoma								19	79					0	0	0.000175454	0	0
EPAS1	2034	broad.mit.edu	37	2	46574202	46574202	+	Splice_Site	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:46574202G>A	ENST00000263734.3	+	2	727	c.217_splice	c.e2+1	p.V73_splice	EPAS1_ENST00000467888.1_3'UTR	NM_001430.4	NP_001421.2	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	73					angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(2)|lung(11)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			CCTCTCCTCAGGTAAGGCCAG	0.592000													11	48					0	0	0.00010058	0	0
RSF1	51773	broad.mit.edu	37	11	77412870	77412870	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:77412870C>T	ENST00000308488.6	-	6	1706	c.1404G>A	c.(1402-1404)aaG>aaA	p.K468K	RSF1_ENST00000360355.2_Silent_p.K437K|RSF1_ENST00000480887.1_Silent_p.K216K			Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	468					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(14)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			AGCTCTCTTCCTTTGTCTCAT	0.398000													4	32					0	0	0.00024832	0	0
MORC4	79710	broad.mit.edu	37	X	106224175	106224175	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:106224175C>T	ENST00000355610.4	-	7	1156	c.882G>A	c.(880-882)atG>atA	p.M294I	MORC4_ENST00000255495.7_Missense_Mutation_p.M294I|MORC4_ENST00000535534.1_Missense_Mutation_p.M42I	NM_001085354.2|NM_024657.4	NP_001078823.1|NP_078933.3	Q8TE76	MORC4_HUMAN	MORC family CW-type zinc finger 4	294							ATP binding|zinc ion binding			endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	28						TCTTGGCAATCATCTGGGTAG	0.398000													7	22					0	0	0.000157383	0	0
PPP2R2B	5521	broad.mit.edu	37	5	145979880	145979880	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr5:145979880C>T	ENST00000394413.3	-	7	1504	c.934G>A	c.(934-936)Gaa>Aaa	p.E312K	PPP2R2B_ENST00000394414.1_Missense_Mutation_p.E378K|PPP2R2B_ENST00000394409.3_Missense_Mutation_p.E370K|PPP2R2B_ENST00000453001.1_Missense_Mutation_p.E312K|PPP2R2B_ENST00000356826.3_Missense_Mutation_p.E312K|PPP2R2B_ENST00000504198.1_Missense_Mutation_p.E318K|PPP2R2B_ENST00000530902.1_5'UTR|PPP2R2B_ENST00000394410.2_Missense_Mutation_p.E301K|PPP2R2B_ENST00000336640.6_Missense_Mutation_p.E315K|PPP2R2B_ENST00000394411.4_Missense_Mutation_p.E312K|CTB-99A3.1_ENST00000512730.1_RNA|PPP2R2B_ENST00000508545.2_Missense_Mutation_p.E301K			Q00005	2ABB_HUMAN	protein phosphatase 2, regulatory subunit B, beta	312					apoptosis|signal transduction	cytoskeleton|mitochondrial outer membrane|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(9)|ovary(1)|prostate(4)|skin(3)	32			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGCGGTTTTCCATGTTGAGA	0.468000													14	29					0	0	0.000308642	0	0
MOV10L1	54456	broad.mit.edu	37	22	50598107	50598107	+	Splice_Site	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr22:50598107G>A	ENST00000262794.5	+	24	3300	c.3216_splice	c.e24-1	p.V1073_splice	MOV10L1_ENST00000395858.3_Splice_Site_p.V1073_splice|MOV10L1_ENST00000395852.1_Splice_Site_p.V200_splice|MOV10L1_ENST00000545383.1_Splice_Site_p.V1073_splice|MOV10L1_ENST00000540615.1_Splice_Site_p.V1053_splice	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	1073					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		TGTTCTCAAGGTGGAGAAAAT	0.338000													16	48					0	0	0.000422831	0	0
TTC3	7267	broad.mit.edu	37	21	38568329	38568329	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr21:38568329T>G	ENST00000399017.2	+	42	8318	c.5571T>G	c.(5569-5571)tgT>tgG	p.C1857W	TTC3_ENST00000355666.1_Missense_Mutation_p.C1857W|TTC3_ENST00000354749.2_Missense_Mutation_p.C1857W|TTC3_ENST00000479930.1_3'UTR	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	1857					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				TATTCCCATGTTACAACAGGT	0.423000													5	38					0	0	3.59834e-05	0	0
PFKFB2	5208	broad.mit.edu	37	1	207235977	207235977	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:207235977G>T	ENST00000367080.3	+	4	348	c.224G>T	c.(223-225)gGg>gTg	p.G75V	PFKFB2_ENST00000367079.2_Missense_Mutation_p.G75V|PFKFB2_ENST00000411990.2_5'UTR|PFKFB2_ENST00000545806.1_Missense_Mutation_p.G42V	NM_006212.2	NP_006203.2	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	75	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	20	Prostate(682;0.19)					TTTAATCTTGGGGTGTATCGG	0.458000													12	498					0.000308642	0.00781611	0.000308642	1	0
SNHG14	104472715	broad.mit.edu	37	15	25304718	25304718	+	RNA	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr15:25304718C>T	ENST00000549804.2	+	0	111				SNHG14_ENST00000384733.1_RNA																							AAAAACATTCCTTGGAAAAGC	0.502000													23	111					0	0	0.000117367	0	0
SPATA32	124783	broad.mit.edu	37	17	43332772	43332772	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:43332772G>A	ENST00000543122.1	-	6	1495	c.714C>T	c.(712-714)ccC>ccT	p.P238P	SPATA32_ENST00000331780.4_Silent_p.P259P|MAP3K14-AS1_ENST00000590100.1_RNA|MAP3K14-AS1_ENST00000588698.1_RNA|MAP3K14-AS1_ENST00000588504.1_RNA|MAP3K14-AS1_ENST00000591263.1_RNA|MAP3K14-AS1_ENST00000588160.1_RNA|MAP3K14-AS1_ENST00000592422.1_RNA|MAP3K14-AS1_ENST00000585346.1_RNA					spermatogenesis associated 32																		GTTCCAAACTGGGCAGGTCCA	0.587000													30	27					0	0	0.000227799	0	0
CTIF	9811	broad.mit.edu	37	18	46146061	46146061	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr18:46146061C>T	ENST00000256413.3	+	2	420	c.125C>T	c.(124-126)gCt>gTt	p.A42V	CTIF_ENST00000382998.4_Missense_Mutation_p.A42V	NM_014772.2	NP_055587.1	O43310	CTIF_HUMAN	CBP80/20-dependent translation initiation factor	42	Interaction with NCBP1/CBP80.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	31						GGGCTGCTGGCTGACAAGACG	0.662000													5	9					0	0	3.59834e-05	0	0
KLHL13	90293	broad.mit.edu	37	X	117033291	117033291	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:117033291G>A	ENST00000371876.1	-	6	3816	c.1395C>T	c.(1393-1395)atC>atT	p.I465I	KLHL13_ENST00000539496.1_Silent_p.I519I|KLHL13_ENST00000540167.1_Silent_p.I500I|KLHL13_ENST00000469946.1_Silent_p.I465I|KLHL13_ENST00000541812.1_Silent_p.I500I|KLHL13_ENST00000262820.3_Silent_p.I516I|KLHL13_ENST00000545703.1_Silent_p.I474I|KLHL13_ENST00000371878.1_Silent_p.I465I|KLHL13_ENST00000371882.1_Silent_p.I465I			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	516					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						GCGCCTTCTGGATCCATTTGT	0.423000													11	35					0	0	0.00010058	0	0
DIDO1	11083	broad.mit.edu	37	20	61511484	61511484	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr20:61511484G>A	ENST00000266070.4	-	16	6149	c.5824C>T	c.(5824-5826)Ccc>Tcc	p.P1942S	DIDO1_ENST00000395343.1_Missense_Mutation_p.P1942S	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	1942	Pro-rich.				apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					AACTGGTTGGGATGAGGGCCC	0.587000													49	162					0	0	0.000147903	0	0
UBE2J2	118424	broad.mit.edu	37	1	1203266	1203266	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:1203266G>A	ENST00000349431.6	-	2	326	c.107C>T	c.(106-108)cCc>cTc	p.P36L	UBE2J2_ENST00000400929.2_Intron|UBE2J2_ENST00000400930.4_Missense_Mutation_p.P36L|UBE2J2_ENST00000347370.2_5'UTR|UBE2J2_ENST00000491779.1_Intron|UBE2J2_ENST00000360466.2_Missense_Mutation_p.P36L|UBE2J2_ENST00000348298.7_5'UTR	NM_058167.2	NP_477515.2	Q8N2K1	UB2J2_HUMAN	ubiquitin-conjugating enzyme E2, J2	36					response to unfolded protein	endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity			cervix(2)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;6.66e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.53e-21)|Colorectal(212;0.00019)|COAD - Colon adenocarcinoma(227;0.000215)|Kidney(185;0.00255)|BRCA - Breast invasive adenocarcinoma(365;0.00266)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0371)|Lung(427;0.205)		CGAAGGGAGGGGCTCGGCACA	0.627000													82	172					0	0	0.000147903	0	0
PPP1R26	9858	broad.mit.edu	37	9	138376596	138376596	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr9:138376596C>T	ENST00000356818.2	+	4	789	c.240C>T	c.(238-240)gaC>gaT	p.D80D	PPP1R26_ENST00000602993.1_Intron|PPP1R26_ENST00000401470.3_Silent_p.D80D|PPP1R26_ENST00000605660.1_Silent_p.D80D|PPP1R26_ENST00000605286.1_Silent_p.D80D|PPP1R26_ENST00000604351.1_Silent_p.D80D	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	80						nucleolus	protein binding										GATGCCACGACGCCAGGCCGG	0.662000													6	37					0	0	8.12818e-05	0	0
TSHZ2	128553	broad.mit.edu	37	20	51872316	51872316	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr20:51872316G>A	ENST00000371497.5	+	2	3206	c.2319G>A	c.(2317-2319)aaG>aaA	p.K773K	TSHZ2_ENST00000329613.6_Silent_p.K770K|TSHZ2_ENST00000603338.2_Silent_p.K770K	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	773					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.K773K(1)		NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			CCAAAAGCAAGAAAGCCGAGT	0.557000													32	108					0	0	8.91981e-05	0	0
NLGN3	54413	broad.mit.edu	37	X	70389545	70389545	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:70389545G>A	ENST00000374051.3	+	7	2407	c.2085G>A	c.(2083-2085)ggG>ggA	p.G695G	NLGN3_ENST00000536169.1_Silent_p.G675G|NLGN3_ENST00000476589.1_3'UTR|NLGN3_ENST00000358741.3_Silent_p.G715G	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	715					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					TCGCCGTGGGGGCCTCCCTCC	0.632000													7	34					0	0	0.000274275	0	0
ARHGAP39	80728	broad.mit.edu	37	8	145773187	145773187	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:145773187G>A	ENST00000276826.5	-	4	1484	c.1283C>T	c.(1282-1284)tCc>tTc	p.S428F	ARHGAP39_ENST00000540274.1_Missense_Mutation_p.S428F|ARHGAP39_ENST00000377307.2_Missense_Mutation_p.S428F			Q9C0H5	RHG39_HUMAN	Rho GTPase activating protein 39	428					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|nucleus	GTPase activator activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22						GGGCTGCAAGGAGTACGAACC	0.711000													4	16					0	0	0.00024832	0	0
LIPF	8513	broad.mit.edu	37	10	90427420	90427420	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:90427420G>A	ENST00000394375.3	+	4	343	c.230G>A	c.(229-231)gGg>gAg	p.G77E	LIPF_ENST00000355843.2_Missense_Mutation_p.G67E|LIPF_ENST00000238983.4_Missense_Mutation_p.G67E	NM_001198829.1	NP_001185758.1	P07098	LIPG_HUMAN	lipase, gastric	67					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity			NS(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(6)	13		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		ATTCCTTATGGGAAGAAAAAT	0.358000													16	114					0	0	9.7654e-05	0	0
REXO1	57455	broad.mit.edu	37	19	1827447	1827447	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:1827447C>T	ENST00000170168.4	-	2	1435	c.1341G>A	c.(1339-1341)ggG>ggA	p.G447G		NM_020695.3	NP_065746.3	Q8N1G1	REXO1_HUMAN	REX1, RNA exonuclease 1 homolog (S. cerevisiae)	447						nucleus	exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	16		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCTCCCTTTCCCTGAGGTGG	0.741000													5	15					0	0	1.23904e-05	0	0
NES	10763	broad.mit.edu	37	1	156642965	156642965	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:156642965G>A	ENST00000368223.3	-	4	1147	c.1015C>T	c.(1015-1017)Cca>Tca	p.P339S		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	339	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CGGCCCTCTGGGGTCCTAGGG	0.587000													6	24					0	0	8.12818e-05	0	0
LOC101928517	101928517	broad.mit.edu	37	19	51671524	51671524	+	RNA	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:51671524C>T	ENST00000600074.1	-	0	493				SIGLEC17P_ENST00000598286.1_RNA														p.I200I(1)									TGCTCACGATCATCCCACGGC	0.632000													8	20					0	0	2.17888e-05	0	0
KRIT1	889	broad.mit.edu	37	7	91842565	91842565	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:91842565G>A	ENST00000394507.1	-	18	2752	c.1969C>T	c.(1969-1971)Cct>Tct	p.P657S	KRIT1_ENST00000412043.2_Missense_Mutation_p.P657S|KRIT1_ENST00000340022.2_Missense_Mutation_p.P657S|KRIT1_ENST00000394503.2_Missense_Mutation_p.P609S|KRIT1_ENST00000394505.2_Missense_Mutation_p.P657S	NM_194456.1	NP_919438.1	O00522	KRIT1_HUMAN	KRIT1, ankyrin repeat containing	657	FERM.|Required for RAP1A binding.				angiogenesis|cell redox homeostasis|negative regulation of angiogenesis|negative regulation of endothelial cell apoptosis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|regulation of establishment of cell polarity|small GTPase mediated signal transduction	cell-cell junction|cytoskeleton	protein binding|small GTPase regulator activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(9)|ovary(2)|stomach(1)	22	all_cancers(62;1.04e-09)|all_epithelial(64;5.75e-09)|Breast(17;0.00206)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			ACATACACAGGGATGACTTTA	0.368000													6	71					0	0	0.000274275	0	0
TTLL4	9654	broad.mit.edu	37	2	219614105	219614105	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:219614105C>T	ENST00000392102.1	+	14	3070	c.2730C>T	c.(2728-2730)tcC>tcT	p.S910S	TTLL4_ENST00000442769.1_Silent_p.S846S|TTLL4_ENST00000258398.4_Silent_p.S910S|TTLL4_ENST00000457313.1_Silent_p.S745S	NM_014640.4	NP_055455.3	Q14679	TTLL4_HUMAN	tubulin tyrosine ligase-like family, member 4	910	TTL.				protein polyglutamylation	cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	39		Renal(207;0.0915)		Epithelial(149;5.03e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0101)		TCAACATTTCCCCAAGGTAGG	0.443000													13	27					0	0	0.000308642	0	0
ZNF683	257101	broad.mit.edu	37	1	26691141	26691141	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:26691141G>A	ENST00000436292.1	-	4	1016	c.896C>T	c.(895-897)cCa>cTa	p.P299L	ZNF683_ENST00000403843.1_Missense_Mutation_p.P299L|ZNF683_ENST00000349618.3_Missense_Mutation_p.P299L|ZNF683_ENST00000374204.1_Missense_Mutation_p.P299L			Q8IZ20	ZN683_HUMAN	zinc finger protein 683	299					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	15		all_cancers(24;2.39e-25)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.00637)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;1.76e-26)|Colorectal(126;1.38e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00793)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.159)|LUSC - Lung squamous cell carcinoma(448;0.233)		GGAACTCAATGGGACCCGCTT	0.587000													47	124					0	0	0.000147903	0	0
SLC30A8	169026	broad.mit.edu	37	8	118184820	118184820	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:118184820C>T	ENST00000427715.2	+	11	1297	c.863C>T	c.(862-864)gCc>gTc	p.A288V	SLC30A8_ENST00000521243.1_Missense_Mutation_p.A288V|SLC30A8_ENST00000456015.2_Missense_Mutation_p.A337V|SLC30A8_ENST00000519688.1_Missense_Mutation_p.A288V	NM_001172813.1|NM_001172815.1	NP_001166284.1|NP_001166286.1	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	337					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			ATTGCTAAAGCCCTTAGCAAA	0.512000													7	26					0	0	2.17888e-05	0	0
ESYT3	83850	broad.mit.edu	37	3	138170908	138170908	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:138170908G>A	ENST00000389567.4	+	2	532	c.346G>A	c.(346-348)Gag>Aag	p.E116K	ESYT3_ENST00000289135.4_Missense_Mutation_p.E116K	NM_031913.3	NP_114119.2	A0FGR9	ESYT3_HUMAN	extended synaptotagmin-like protein 3	116						integral to membrane|plasma membrane				breast(1)|endometrium(5)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	25						CCCGGACGTGGAGCGGGTCGA	0.672000													44	210					0	0	0.000147903	0	0
ZDBF2	57683	broad.mit.edu	37	2	207174295	207174295	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:207174295G>A	ENST00000374423.3	+	5	5429	c.5043G>A	c.(5041-5043)caG>caA	p.Q1681Q		NM_020923.1	NP_065974.1	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	1681							nucleic acid binding|zinc ion binding			endometrium(4)|kidney(5)|large_intestine(28)|lung(50)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	95						ACCGACTGCAGAAAGCTCACA	0.413000													7	31					0	0	0.000157383	0	0
LRP2	4036	broad.mit.edu	37	2	170031750	170031750	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:170031750G>T	ENST00000263816.3	-	55	11006	c.10721C>A	c.(10720-10722)gCt>gAt	p.A3574D		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	3574	LDL-receptor class A 27.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATTTTGGTGAGCATTGCATAA	0.517000													15	73					4.63292e-17	1.20366e-15	0.000132079	1	0
DMBT1	1755	broad.mit.edu	37	10	124350197	124350197	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:124350197G>A	ENST00000368909.3	+	18	2230	c.2124G>A	c.(2122-2124)tcG>tcA	p.S708S	DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000368955.3_Silent_p.S698S|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000344338.3_Silent_p.S698S|DMBT1_ENST00000338354.3_Silent_p.S708S|DMBT1_ENST00000330163.4_Intron	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	708					epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				AGTCCCGGTCGACGCCCAGGC	0.507000													142	254					0	0	0.000147903	0	0
ANK1	286	broad.mit.edu	37	8	41585483	41585483	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:41585483C>T	ENST00000396942.1	-	4	353	c.270G>A	c.(268-270)caG>caA	p.Q90Q	ANK1_ENST00000289734.7_Silent_p.Q90Q|ANK1_ENST00000379758.2_Silent_p.Q90Q|ANK1_ENST00000352337.4_Silent_p.Q90Q|ANK1_ENST00000347528.4_Silent_p.Q90Q|ANK1_ENST00000265709.8_Silent_p.Q123Q|ANK1_ENST00000396945.1_Silent_p.Q90Q			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	90	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CCACCTCATCCTGCCCGGCTA	0.602000													23	41					0	0	0.000227799	0	0
SBNO1	55206	broad.mit.edu	37	12	123829915	123829915	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:123829915G>A	ENST00000420886.2	-	3	439	c.440C>T	c.(439-441)cCt>cTt	p.P147L	SBNO1_ENST00000602750.1_Missense_Mutation_p.P146L|SBNO1_ENST00000602398.1_Missense_Mutation_p.P147L|SBNO1_ENST00000267176.4_Missense_Mutation_p.P146L	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	147							ATP binding|DNA binding|hydrolase activity			NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		GTCTTTTGAAGGTGCAGAGGT	0.418000													47	106					0	0	0.000147903	0	0
SLC12A6	9990	broad.mit.edu	37	15	34542930	34542930	+	Splice_Site	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr15:34542930C>T	ENST00000354181.3	-	12	1985	c.1492_splice	c.e12-1	p.G498_splice	SLC12A6_ENST00000560611.1_Splice_Site_p.G498_splice|SLC12A6_ENST00000558589.1_Splice_Site_p.G489_splice|SLC12A6_ENST00000558667.1_Splice_Site_p.G498_splice|SLC12A6_ENST00000451844.2_Splice_Site_p.G310_splice|SLC12A6_ENST00000458406.2_Splice_Site_p.G439_splice|SLC12A6_ENST00000397702.2_Splice_Site_p.G439_splice|SLC12A6_ENST00000397707.2_Splice_Site_p.G483_splice|SLC12A6_ENST00000560164.1_Splice_Site_p.G310_splice|SLC12A6_ENST00000290209.5_Splice_Site_p.G447_splice			Q9UHW9	S12A6_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 6	498					angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|skin(3)	45		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	AGCCATGATACCTTTAGAGAT	0.403000													12	35					0	0	0.000151284	0	0
SULT1B1	27284	broad.mit.edu	37	4	70599213	70599213	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:70599213G>A	ENST00000310613.2	-	6	812	c.515C>T	c.(514-516)tCc>tTc	p.S172F		NM_014465.3	NP_055280.2	O43704	ST1B1_HUMAN	sulfotransferase family, cytosolic, 1B, member 1	172					3'-phosphoadenosine 5'-phosphosulfate metabolic process|cellular biogenic amine metabolic process|flavonoid metabolic process|steroid metabolic process|sulfation|thyroid hormone metabolic process|xenobiotic metabolic process	cytosol				breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(14)|prostate(1)|upper_aerodigestive_tract(1)	24						AGTAAACCAGGAACCATAGGC	0.294000													51	93					0	0	0.000147903	0	0
HEATR1	55127	broad.mit.edu	37	1	236720519	236720519	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:236720519G>A	ENST00000366582.3	-	37	5445	c.5331C>T	c.(5329-5331)ccC>ccT	p.P1777P	HEATR1_ENST00000366581.2_Silent_p.P1696P	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	1777					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CTTCCAGATAGGGGCTGATGA	0.542000													6	19					0	0	0.000274275	0	0
OR5D14	219436	broad.mit.edu	37	11	55563485	55563485	+	Missense_Mutation	SNP	C	C	T	rs138241507		TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:55563485C>T	ENST00000335605.1	+	1	454	c.454C>T	c.(454-456)Ctc>Ttc	p.L152F		NM_001004735.1	NP_001004735.1	Q8NGL3	OR5DE_HUMAN	olfactory receptor, family 5, subfamily D, member 14	152					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(30)|ovary(2)|prostate(1)|skin(2)|stomach(3)|urinary_tract(1)	48		all_epithelial(135;0.196)				TGGGTCATATCTCTGGGGCAT	0.498000													4	17					0	0	0.00024832	0	0
NAP1L2	4674	broad.mit.edu	37	X	72434266	72434266	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:72434266C>T	ENST00000373517.3	-	1	418	c.63G>A	c.(61-63)caG>caA	p.Q21Q	NAP1L2_ENST00000536638.1_Intron	NM_021963.3	NP_068798.1	Q9ULW6	NP1L2_HUMAN	nucleosome assembly protein 1-like 2	21					nucleosome assembly	chromatin assembly complex				NS(1)|breast(2)|endometrium(2)|kidney(3)|large_intestine(6)|lung(12)|skin(3)	29	Renal(35;0.156)					CCACCATTATCTGATTACCAG	0.567000													40	81					0	0	0.000106405	0	0
CDH10	1008	broad.mit.edu	37	5	24488092	24488092	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr5:24488092C>T	ENST00000264463.4	-	12	2554	c.2047G>A	c.(2047-2049)Gaa>Aaa	p.E683K	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	683					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		AGCTTTTTTTCCTCAATGGCT	0.478000										HNSCC(23;0.051)			7	17					0	0	0.000274275	0	0
SLC28A1	9154	broad.mit.edu	37	15	85438173	85438173	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr15:85438173C>T	ENST00000394573.1	+	6	482	c.280C>T	c.(280-282)Ctc>Ttc	p.L94F	SLC28A1_ENST00000537703.1_Missense_Mutation_p.L16F|SLC28A1_ENST00000537216.1_Missense_Mutation_p.L94F|SLC28A1_ENST00000286749.3_Missense_Mutation_p.L94F|SLC28A1_ENST00000538177.1_Missense_Mutation_p.L94F|SLC28A1_ENST00000338602.2_Missense_Mutation_p.L94F|SLC28A1_ENST00000537624.1_Missense_Mutation_p.L94F	NM_004213.3	NP_004204.3	O00337	S28A1_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 1	94					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			breast(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	41			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TCCCCCAGGGCTCTCTGCCTT	0.647000													26	87					0	0	8.91981e-05	0	0
JSRP1	126306	broad.mit.edu	37	19	2252666	2252666	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:2252666C>T	ENST00000300961.5	-	7	722	c.658G>A	c.(658-660)Gga>Aga	p.G220R	JSRP1_ENST00000586471.1_Missense_Mutation_p.G220R	NM_144616.3	NP_653217.1	Q96MG2	JSPR1_HUMAN	junctional sarcoplasmic reticulum protein 1	220						sarcoplasmic reticulum membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|pancreas(1)|urinary_tract(1)	6				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACGGCCTCTCCGGTGGCCTCG	0.711000													39	85					0	0	0.000374591	0	0
AZU1	566	broad.mit.edu	37	19	829624	829624	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:829624C>T	ENST00000233997.2	+	3	299	c.278C>T	c.(277-279)tCc>tTc	p.S93F		NM_001700.3	NP_001691.1	P20160	CAP7_HUMAN	azurocidin 1	93	Peptidase S1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cellular extravasation|defense response to Gram-negative bacterium|glial cell migration|induction of positive chemotaxis|inflammatory response|macrophage chemotaxis|microglial cell activation|monocyte activation|positive regulation of cell adhesion|positive regulation of fractalkine biosynthetic process|positive regulation of interleukin-1 beta biosynthetic process|positive regulation of MHC class II biosynthetic process|positive regulation of phagocytosis|positive regulation of tumor necrosis factor biosynthetic process|proteolysis|regulation of vascular permeability	azurophil granule|extracellular region	heparin binding|serine-type endopeptidase activity|toxin binding			NS(1)|endometrium(1)|kidney(1)|lung(4)|pancreas(1)|upper_aerodigestive_tract(2)	10		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GAGAGGCAGTCCCGCCAGACG	0.617000													13	60					0	0	0.000219431	0	0
OR2T4	127074	broad.mit.edu	37	1	248525516	248525516	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:248525516G>A	ENST00000366475.1	+	1	634	c.634G>A	c.(634-636)Gaa>Aaa	p.E212K		NM_001004696.1	NP_001004696.1	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T, member 4	212					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(2)|lung(47)	56	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTTCTTCTGTGAAGTTCCTGC	0.502000													25	23					0	0	5.49717e-05	0	0
NFATC4	4776	broad.mit.edu	37	14	24842431	24842431	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:24842431G>A	ENST00000413692.2	+	5	1747	c.1603G>A	c.(1603-1605)Gat>Aat	p.D535N	NFATC4_ENST00000555167.1_Missense_Mutation_p.D7N|NFATC4_ENST00000554050.1_Missense_Mutation_p.D472N|NFATC4_ENST00000553708.1_Missense_Mutation_p.D472N|NFATC4_ENST00000555590.1_Missense_Mutation_p.D485N|NFATC4_ENST00000539237.2_Missense_Mutation_p.D504N|NFATC4_ENST00000554661.1_Missense_Mutation_p.D402N|NFATC4_ENST00000424781.2_Missense_Mutation_p.D485N|NFATC4_ENST00000554473.1_Missense_Mutation_p.D7N|NFATC4_ENST00000250373.4_Missense_Mutation_p.D472N|NFATC4_ENST00000554344.1_Missense_Mutation_p.D402N|NFATC4_ENST00000556759.1_Missense_Mutation_p.D7N|NFATC4_ENST00000553879.1_Missense_Mutation_p.D402N|NFATC4_ENST00000556279.1_Missense_Mutation_p.D504N|NFATC4_ENST00000553469.1_Missense_Mutation_p.D504N|NFATC4_ENST00000554591.1_Missense_Mutation_p.D535N|NFATC4_ENST00000556169.1_Missense_Mutation_p.D460N|NFATC4_ENST00000557451.1_Missense_Mutation_p.D402N|NFATC4_ENST00000555453.1_Missense_Mutation_p.D460N|NFATC4_ENST00000554966.1_Missense_Mutation_p.D485N|NFATC4_ENST00000422617.3_Missense_Mutation_p.D460N	NM_001136022.1|NM_001198967.1	NP_001129494.1|NP_001185896.1	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	472	RHD.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(7)|liver(4)|lung(12)|ovary(1)|skin(2)	34				GBM - Glioblastoma multiforme(265;0.018)		CGGCACTGCAGATGAAAGGAA	0.567000													44	58					0	0	0.000147903	0	0
DNAH8	1769	broad.mit.edu	37	6	38781865	38781865	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:38781865C>T	ENST00000359357.3	+	23	2896	c.2642C>T	c.(2641-2643)tCc>tTc	p.S881F	DNAH8_ENST00000449981.2_Missense_Mutation_p.S1098F|DNAH8_ENST00000441566.1_Missense_Mutation_p.S881F					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GATATTATTTCCTTTATAAAA	0.313000													9	54					0	0	6.40141e-05	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520358	33520358	+	Silent	SNP	A	A	G	rs74740601	by1000genomes	TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:33520358A>G	ENST00000297307.5	-	1	1054	c.969T>C	c.(967-969)atT>atC	p.I323I		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	323	DUF6 2.					integral to membrane		p.I323I(1)									TCTGGGCTGTAATGATGGCAA	0.547000													5	126					0	0	3.59834e-05	0	0
KIAA1210	57481	broad.mit.edu	37	X	118222375	118222375	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:118222375C>T	ENST00000402510.2	-	11	2817	c.2818G>A	c.(2818-2820)Gat>Aat	p.D940N		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	940										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						TCCACGGAATCGCTCTGTTTT	0.512000													6	27					0	0	8.12818e-05	0	0
LAMA2	3908	broad.mit.edu	37	6	129649516	129649516	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:129649516G>A	ENST00000421865.2	+	29	4319	c.4270G>A	c.(4270-4272)Gga>Aga	p.G1424R		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1424	Laminin EGF-like 15.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		TCAATGTAATGGACACAGCAG	0.527000													10	22					0	0	2.17888e-05	0	0
RBM46	166863	broad.mit.edu	37	4	155720135	155720135	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:155720135C>T	ENST00000510397.1	+	4	1000	c.821C>T	c.(820-822)gCt>gTt	p.A274V	RBM46_ENST00000281722.3_Missense_Mutation_p.A274V|RBM46_ENST00000514866.1_Missense_Mutation_p.A274V	NM_001277173.1	NP_001264102.1	Q8TBY0	RBM46_HUMAN	RNA binding motif protein 46	274	RRM 3.						nucleotide binding|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(7)|skin(3)|urinary_tract(2)	26	all_hematologic(180;0.24)	Renal(120;0.0854)				AGAGATTATGCTTTTGTTCAC	0.358000													12	21					0	0	0.00010058	0	0
SORCS3	22986	broad.mit.edu	37	10	106924131	106924131	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:106924131G>A	ENST00000369701.3	+	12	2030	c.1803G>A	c.(1801-1803)tgG>tgA	p.W601*		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	601						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GCAACACATGGAGACAGGTAA	0.443000													5	7					0	0	3.59834e-05	0	0
GYS2	2998	broad.mit.edu	37	12	21716251	21716251	+	Silent	SNP	A	A	G			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:21716251A>G	ENST00000261195.2	-	6	1106	c.852T>C	c.(850-852)gtT>gtC	p.V284V		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	284					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						AAAATTTCTTAACATTCAAGC	0.338000													37	58					0	0	0.000132358	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8665993	8665993	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:8665993C>G	ENST00000270328.4	-	5	895	c.629G>C	c.(628-630)cGg>cCg	p.R210P	ADAMTS10_ENST00000596709.1_5'UTR|ADAMTS10_ENST00000597188.1_Missense_Mutation_p.R210P			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	210					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						CTTCAAGGTCCGCAGCCACCA	0.637000													12	36					0	0	0.000422831	0	0
TNRC18	84629	broad.mit.edu	37	7	5427351	5427351	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:5427351G>A	ENST00000399537.4	-	5	2452	c.2104C>T	c.(2104-2106)Cct>Tct	p.P702S	TNRC18_ENST00000430969.1_Missense_Mutation_p.P702S			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	702							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		ACCAGCCCAGGCCCCAGCCGG	0.662000													17	82					0	0	5.49717e-05	0	0
NAALAD2	10003	broad.mit.edu	37	11	89891349	89891349	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:89891349G>A	ENST00000534061.1	+	7	1063	c.833G>A	c.(832-834)gGa>gAa	p.G278E	NAALAD2_ENST00000525171.1_Intron|NAALAD2_ENST00000321955.4_Missense_Mutation_p.G278E|NAALAD2_ENST00000375944.3_Intron	NM_005467.3	NP_005458.1	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	278	NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(32)|pancreas(1)|prostate(3)|skin(5)|stomach(2)	59		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				GAAGGAGTGGGAATCCCCCGA	0.318000													17	72					0	0	0.000175454	0	0
USP8	9101	broad.mit.edu	37	15	50733667	50733667	+	Nonsense_Mutation	SNP	A	A	T	rs148744702		TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr15:50733667A>T	ENST00000433963.1	+	4	726	c.226A>T	c.(226-228)Aga>Tga	p.R76*	USP8_ENST00000558892.1_3'UTR|USP8_ENST00000396444.3_Nonsense_Mutation_p.R76*|USP8_ENST00000425032.3_Intron|USP8_ENST00000307179.4_Nonsense_Mutation_p.R76*	NM_001128611.1	NP_001122083.1	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	76	MIT.				cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		TATCAAAAAAAGACCTGATTT	0.303000													15	32					0	0	0.000422831	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255119	15255119	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:15255119C>T	ENST00000378116.4	-	8	2474	c.2468G>A	c.(2467-2469)aGa>aAa	p.R823K		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	823						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						GCCACCACTTCTCCGACTCGA	0.642000													25	64					0	0	5.49717e-05	0	0
MAGEE2	139599	broad.mit.edu	37	X	75004478	75004478	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:75004478C>T	ENST00000373359.2	-	1	601	c.409G>A	c.(409-411)Gac>Aac	p.D137N		NM_138703.4	NP_619648.1	Q8TD90	MAGE2_HUMAN	melanoma antigen family E, 2	137	MAGE 1.									autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						AAGACCTGGTCCAGGTGAGCT	0.522000													5	8					0	0	1.23904e-05	0	0
KRT20	54474	broad.mit.edu	37	17	39036116	39036116	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:39036116C>T	ENST00000167588.3	-	5	908	c.867G>A	c.(865-867)ctG>ctA	p.L289L		NM_019010.2	NP_061883.1	P35900	K1C20_HUMAN	keratin 20	289	Coil 2.|Rod.				apoptosis|intermediate filament organization	Golgi apparatus|intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(1)	14		Breast(137;0.000301)|Ovarian(249;0.15)				AGGTGCGTCTCAGCTCCGTTA	0.428000													41	46					0	0	0.000147903	0	0
CXCL12	6387	broad.mit.edu	37	10	44871456	44871456	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:44871456C>T	ENST00000374426.2	-	4	328	c.291G>A	c.(289-291)ggG>ggA	p.G97G	CXCL12_ENST00000395793.3_Intron|CXCL12_ENST00000374429.2_Intron|CXCL12_ENST00000395795.4_Intron	NM_001033886.2	NP_001029058.1	P48061	SDF1_HUMAN	chemokine (C-X-C motif) ligand 12	0					blood circulation|cell adhesion|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|negative regulation of leukocyte apoptosis|positive regulation of monocyte chemotaxis|regulation of actin polymerization or depolymerization|response to virus	extracellular space	chemokine activity|growth factor activity|signal transducer activity			endometrium(1)|large_intestine(1)|lung(3)|skin(1)	6					Dexamethasone(DB01234)	TTTCTTTTTTCCCCACTTTTT	0.383000													57	385					0	0	0.000147903	0	0
OPN4	94233	broad.mit.edu	37	10	88419090	88419090	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:88419090C>T	ENST00000372071.2	+	6	925	c.698C>T	c.(697-699)tCc>tTc	p.S233F	OPN4_ENST00000241891.5_Missense_Mutation_p.S222F	NM_001030015.2	NP_001025186.1	Q9UHM6	OPN4_HUMAN	opsin 4	222					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(5)|ovary(3)	18						ACATCCTGCTCCTGGGACTAC	0.612000													16	80					0	0	0.000308642	0	0
RAI2	10742	broad.mit.edu	37	X	17819465	17819465	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:17819465G>A	ENST00000545871.1	-	3	1126	c.666C>T	c.(664-666)tcC>tcT	p.S222S	RAI2_ENST00000360011.1_Silent_p.S222S|RAI2_ENST00000451717.1_Silent_p.S222S|RAI2_ENST00000415486.3_Silent_p.S172S|RAI2_ENST00000331511.1_Silent_p.S222S	NM_001172739.1|NM_001172743.1	NP_001166210.1|NP_001166214.1	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	222	Pro-rich.				embryo development					breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	22	Hepatocellular(33;0.183)					GGACCAGGGGGGACAAGGGGG	0.622000													10	39					0	0	2.17888e-05	0	0
ABCA12	26154	broad.mit.edu	37	2	215890504	215890504	+	Splice_Site	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:215890504C>T	ENST00000272895.7	-	11	1400		c.e11-1		AC072062.3_ENST00000437897.3_RNA|ABCA12_ENST00000389661.4_Splice_Site	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12						cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		CTTAGATTTTCTGTAAAGGAA	0.358000													30	60					0	0	0.000227799	0	0
ZNF341	84905	broad.mit.edu	37	20	32369172	32369172	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr20:32369172C>T	ENST00000375200.1	+	11	2063	c.1698C>T	c.(1696-1698)ttC>ttT	p.F566F	ZNF341_ENST00000342427.2_Silent_p.F559F			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	566					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						CTCACAACTTCCCCTGCCCAC	0.577000													37	65					0	0	0.000228196	0	0
CDH8	1006	broad.mit.edu	37	16	61854894	61854894	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr16:61854894C>T	ENST00000577390.1	-	6	1913	c.959G>A	c.(958-960)gGa>gAa	p.G320E	CDH8_ENST00000584337.1_Missense_Mutation_p.G320E|CDH8_ENST00000299345.6_Missense_Mutation_p.G320E|CDH8_ENST00000577730.1_Missense_Mutation_p.G320E	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	320	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		AAGTGCTGTTCCATCTCCATC	0.408000													4	5					0	0	0.00024832	0	0
MUC6	4588	broad.mit.edu	37	11	1019477	1019477	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:1019477C>T	ENST00000421673.2	-	30	3878	c.3828G>A	c.(3826-3828)acG>acA	p.T1276T		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1276	Pro-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGGTGACGGCCGTGGTTGGTC	0.637000													26	113					0	0	9.22233e-05	0	0
ZC4H2	55906	broad.mit.edu	37	X	64138969	64138969	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:64138969C>T	ENST00000545618.1	-	5	1062	c.499G>A	c.(499-501)Gat>Aat	p.D167N	ZC4H2_ENST00000374839.3_Missense_Mutation_p.D172N|ZC4H2_ENST00000488608.1_5'UTR|ZC4H2_ENST00000337990.2_Missense_Mutation_p.D149N|ZC4H2_ENST00000447788.2_Intron			Q9NQZ6	ZC4H2_HUMAN	zinc finger, C4H2 domain containing	172							metal ion binding|protein binding			endometrium(2)|large_intestine(4)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	24						TGCCGAGTATCCTGCTTCCTA	0.597000													17	31					0	0	5.01169e-05	0	0
PTPRB	5787	broad.mit.edu	37	12	70949773	70949773	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:70949773C>T	ENST00000334414.6	-	19	4914	c.4870G>A	c.(4870-4872)Gaa>Aaa	p.E1624K	PTPRB_ENST00000261266.5_Missense_Mutation_p.E1406K|PTPRB_ENST00000550857.1_Missense_Mutation_p.E1316K|PTPRB_ENST00000550358.1_Missense_Mutation_p.E1536K|PTPRB_ENST00000538708.1_Missense_Mutation_p.E1316K|PTPRB_ENST00000451516.2_Missense_Mutation_p.E1316K	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1406					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			AGAGATTTTTCTTTCTCCAGC	0.468000													4	11					0	0	1.23904e-05	0	0
FAM65C	140876	broad.mit.edu	37	20	49224937	49224937	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr20:49224937C>T	ENST00000327979.2	-	11	1344	c.933G>A	c.(931-933)gaG>gaA	p.E311E	FAM65C_ENST00000045083.2_Silent_p.E311E|FAM65C_ENST00000535356.1_Silent_p.E315E			Q96MK2	FA65C_HUMAN	family with sequence similarity 65, member C	311										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|liver(1)|lung(12)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						TCCACTGCACCTCCAGCTGCA	0.652000													32	39					0	0	0.000109025	0	0
OPALIN	93377	broad.mit.edu	37	10	98105749	98105749	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:98105749C>T	ENST00000419479.1	-	7	852	c.345G>A	c.(343-345)atG>atA	p.M115I	OPALIN_ENST00000393871.1_Missense_Mutation_p.M102I|OPALIN_ENST00000536387.1_Missense_Mutation_p.M115I|OPALIN_ENST00000371172.3_Missense_Mutation_p.M125I|OPALIN_ENST00000393870.2_Missense_Mutation_p.M114I	NM_001040103.1	NP_001035192.1	Q96PE5	OPALI_HUMAN	oligodendrocytic myelin paranodal and inner loop protein	125						Golgi apparatus|integral to membrane|plasma membrane				breast(1)|large_intestine(1)|lung(5)|prostate(2)	9						TCCTTCTTTCCATTTCTATAG	0.512000													5	6					0	0	3.59834e-05	0	0
ZNF470	388566	broad.mit.edu	37	19	57089571	57089571	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:57089571C>T	ENST00000330619.8	+	6	2460	c.1774C>T	c.(1774-1776)Ccg>Tcg	p.P592S	ZNF470_ENST00000391709.3_Missense_Mutation_p.P592S|ZNF470_ENST00000601902.1_Intron	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	592					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		TGGCAAAAGACCGTATGAATG	0.428000													5	26					0	0	1.23904e-05	0	0
RNPS1	10921	broad.mit.edu	37	16	2305647	2305647	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr16:2305647G>A	ENST00000565678.1	-	7	1302	c.757C>T	c.(757-759)Ccc>Tcc	p.P253S	RNPS1_ENST00000566397.1_Missense_Mutation_p.P76S|RNPS1_ENST00000568631.1_Missense_Mutation_p.P253S|RNPS1_ENST00000569598.2_Missense_Mutation_p.P159S|RNPS1_ENST00000566458.1_Missense_Mutation_p.P230S|AC009065.1_ENST00000454671.1_Missense_Mutation_p.G130E|RNPS1_ENST00000567147.1_Intron|RNPS1_ENST00000561718.1_Missense_Mutation_p.P76S|RNPS1_ENST00000320225.5_Missense_Mutation_p.P253S|RNPS1_ENST00000397086.2_Missense_Mutation_p.P253S|RNPS1_ENST00000301730.8_Missense_Mutation_p.P253S			Q15287	RNPS1_HUMAN	RNA binding protein S1, serine-rich domain	253	Arg/Pro-rich.|Necessary for interaction with TRA2B, nuclear localization and exon-skipping.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|termination of RNA polymerase II transcription	cytosol|nuclear speck	mRNA 3'-UTR binding|nucleotide binding|protein binding			endometrium(1)|large_intestine(1)|lung(4)|ovary(2)|urinary_tract(1)	9						ATTCTCCTGGGAGGGCTGAAT	0.572000													26	43					0	0	0.000147802	0	0
ZNF610	162963	broad.mit.edu	37	19	52869869	52869869	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:52869869T>C	ENST00000601151.1	+	5	1561	c.1109T>C	c.(1108-1110)tTa>tCa	p.L370S	ZNF610_ENST00000327920.8_Missense_Mutation_p.L413S|ZNF610_ENST00000403906.3_Missense_Mutation_p.L413S|ZNF610_ENST00000321287.8_Missense_Mutation_p.L413S	NM_001161427.1	NP_001154899.1	Q8N9Z0	ZN610_HUMAN	zinc finger protein 610	413					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(8)|liver(2)|lung(9)|ovary(2)|stomach(2)|upper_aerodigestive_tract(2)	34				OV - Ovarian serous cystadenocarcinoma(262;0.00396)|GBM - Glioblastoma multiforme(134;0.00434)		GGGCGCAAATTATACCTAACC	0.423000													14	34					0	0	0.000308642	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994657	140994657	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:140994657C>T	ENST00000285879.4	+	4	1753	c.1467C>T	c.(1465-1467)tcC>tcT	p.S489S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	489							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CCTCCTCCTCCACTTTATTGA	0.493000										HNSCC(15;0.026)			60	137					0	0	0.000147903	0	0
SGSM1	129049	broad.mit.edu	37	22	25251323	25251323	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr22:25251323G>A	ENST00000400358.4	+	7	652	c.595G>A	c.(595-597)Gaa>Aaa	p.E199K	SGSM1_ENST00000400359.4_Missense_Mutation_p.E199K	NM_001098497.1|NM_001098498.1	NP_001091967.1|NP_001091968.1	Q2NKQ1	SGSM1_HUMAN	small G protein signaling modulator 1	199						Golgi apparatus	Rab GTPase activator activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(14)|lung(10)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	41						CTCGGCTGACGAACTTGTCCA	0.627000													19	12					0	0	0.000132079	0	0
MAGED1	9500	broad.mit.edu	37	X	51638416	51638416	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:51638416A>G	ENST00000375695.2	+	4	634	c.481A>G	c.(481-483)Aac>Gac	p.N161D	MAGED1_ENST00000375772.3_Missense_Mutation_p.N105D|MAGED1_ENST00000494718.1_3'UTR|MAGED1_ENST00000326587.7_Missense_Mutation_p.N105D|MAGED1_ENST00000375722.1_Missense_Mutation_p.N105D	NM_001005333.1	NP_001005333.1	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1	105					apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			breast(1)|endometrium(4)|large_intestine(10)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	32	Ovarian(276;0.236)					GGATGTGCCCAACACGCAGCC	0.502000										Multiple Myeloma(10;0.10)			5	21					0	0	3.59834e-05	0	0
LTBP2	4053	broad.mit.edu	37	14	75078537	75078537	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:75078537C>T	ENST00000261978.4	-	1	497	c.111G>A	c.(109-111)agG>agA	p.R37R	LTBP2_ENST00000557425.1_Intron|LTBP2_ENST00000556690.1_Silent_p.R37R	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	37			R -> M (in dbSNP:rs934996).		protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		CTACGGGGTCCCTTTGGGCAT	0.706000													15	37					0	0	5.01169e-05	0	0
ZNF596	169270	broad.mit.edu	37	8	195562	195562	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:195562C>T	ENST00000398612.1	+	6	1098	c.715C>T	c.(715-717)Cga>Tga	p.R239*	ZNF596_ENST00000308811.4_Nonsense_Mutation_p.R239*|ZNF596_ENST00000320552.2_Nonsense_Mutation_p.R169*	NM_001042415.1|NM_001042416.1	NP_001035880.1|NP_001035881.1	Q8TC21	ZN596_HUMAN	zinc finger protein 596	239					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(5)	14		all_cancers(2;4.81e-29)|all_epithelial(2;5.03e-19)|Lung NSC(2;8.68e-08)|all_lung(2;1.52e-07)|Ovarian(12;0.00965)|Colorectal(14;0.0367)|all_neural(12;0.0837)|Myeloproliferative disorder(644;0.116)|all_hematologic(2;0.138)|Acute lymphoblastic leukemia(644;0.242)		Epithelial(5;3.77e-18)|all cancers(2;5.2e-17)|OV - Ovarian serous cystadenocarcinoma(5;5.37e-09)|BRCA - Breast invasive adenocarcinoma(11;1.7e-06)|Colorectal(2;6.51e-05)|READ - Rectum adenocarcinoma(2;0.0276)|COAD - Colon adenocarcinoma(149;0.0702)		CTCTGATCTTCGAAAACATGA	0.413000													6	23					0	0	3.59834e-05	0	0
KIF24	347240	broad.mit.edu	37	9	34256461	34256461	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr9:34256461G>A	ENST00000379166.2	-	11	3263	c.3144C>T	c.(3142-3144)ctC>ctT	p.L1048L	KIF24_ENST00000379174.3_Silent_p.L914L|KIF24_ENST00000402558.2_Silent_p.L1048L|KIF24_ENST00000345050.2_Silent_p.L914L	NM_194313.2	NP_919289.2	Q5T7B8	KIF24_HUMAN	kinesin family member 24	1048					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|liver(1)|lung(13)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	32			LUSC - Lung squamous cell carcinoma(29;0.0107)			GGGGAGACATGAGTCCAGAAG	0.582000													34	34					0	0	0.000228196	0	0
SLC45A4	57210	broad.mit.edu	37	8	142229077	142229077	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:142229077G>A	ENST00000519067.1	-	4	812	c.509C>T	c.(508-510)aCc>aTc	p.T170I	SLC45A4_ENST00000433583.2_Missense_Mutation_p.T163I|SLC45A4_ENST00000024061.3_Missense_Mutation_p.T170I|SLC45A4_ENST00000517878.1_Missense_Mutation_p.T221I			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	221					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GCCCAGGAAGGTCTGGGTCCA	0.657000													11	74					0	0	0.000219431	0	0
EYA1	2138	broad.mit.edu	37	8	72184096	72184096	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:72184096T>C	ENST00000340726.3	-	10	1502	c.863A>G	c.(862-864)aAa>aGa	p.K288R	EYA1_ENST00000388741.2_Missense_Mutation_p.K254R|EYA1_ENST00000388743.2_Missense_Mutation_p.K287R|EYA1_ENST00000388742.4_Missense_Mutation_p.K288R|EYA1_ENST00000388740.3_Missense_Mutation_p.K255R|EYA1_ENST00000419131.1_Missense_Mutation_p.K283R|EYA1_ENST00000303824.7_Missense_Mutation_p.K282R	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	288					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			ATCTGAATCTTTAATGGGTGT	0.453000													33	68					0	0	0.000191422	0	0
TCHHL1	126637	broad.mit.edu	37	1	152058306	152058306	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:152058306C>T	ENST00000368806.1	-	3	1916	c.1852G>A	c.(1852-1854)Gat>Aat	p.D618N		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	618							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			AGCTGTACATCCTCTCCTCTG	0.557000													16	58					0	0	7.07596e-05	0	0
ZNF783	100289678	broad.mit.edu	37	7	148975604	148975604	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:148975604C>T	ENST00000434415.1	+	5	951	c.788C>T	c.(787-789)gCc>gTc	p.A263V	ZNF783_ENST00000489518.1_3'UTR	NM_001195220.1	NP_001182149.1	C9J9J2	C9J9J2_HUMAN	zinc finger family member 783	263					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)	22	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.0014)			GTGGCCCCAGCCGGGCCAGAA	0.642000													11	29					0	0	0.000151284	0	0
SLC41A1	254428	broad.mit.edu	37	1	205779249	205779249	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:205779249G>A	ENST00000367137.3	-	2	1335	c.321C>T	c.(319-321)ctC>ctT	p.L107L		NM_173854.4	NP_776253.3	Q8IVJ1	S41A1_HUMAN	solute carrier family 41 (magnesium transporter), member 1	107						integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	17	Breast(84;0.0799)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			AGCCTGCCAGGAGGAATGGAA	0.597000													39	55					0	0	0.000270559	0	0
SYCP1	6847	broad.mit.edu	37	1	115401177	115401177	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:115401177G>A	ENST00000369522.3	+	6	541	c.301G>A	c.(301-303)Gga>Aga	p.G101R	SYCP1_ENST00000369518.1_Missense_Mutation_p.G101R	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	101					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAATTCAGAGGGATTGAGCAG	0.299000													8	104					0	0	2.17888e-05	0	0
RMI2	116028	broad.mit.edu	37	16	11444541	11444541	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr16:11444541C>T	ENST00000572173.1	+	5	794	c.149C>T	c.(148-150)cCt>cTt	p.P50L	RMI2_ENST00000576027.1_3'UTR|RMI2_ENST00000381820.2_Missense_Mutation_p.P50L|RMI2_ENST00000312499.5_Missense_Mutation_p.P113L			Q96E14	RMI2_HUMAN	RecQ mediated genome instability 2	113					DNA replication	nucleus	DNA binding			endometrium(1)|kidney(1)|ovary(1)	3						GCCTGCAGCCCTGAGCCCTGC	0.423000													34	87					0	0	0.000228196	0	0
KDR	3791	broad.mit.edu	37	4	55956220	55956220	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:55956220C>T	ENST00000263923.4	-	23	3390	c.3095G>A	c.(3094-3096)cGa>cAa	p.R1032Q	RP11-530I17.1_ENST00000511222.1_RNA	NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1032	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity	p.R1032Q(2)		NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GAGGATATTTCGTGCCGCCAG	0.448000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			12	24					0	0	0.000308642	0	0
MTOR	2475	broad.mit.edu	37	1	11199666	11199666	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:11199666G>A	ENST00000361445.4	-	35	4998	c.4922C>T	c.(4921-4923)tCc>tTc	p.S1641F	MTOR_ENST00000495435.1_5'UTR	NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	1641	FAT.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						GACCACAAGGGACCGCACCAT	0.502000													30	86					0	0	0.000132358	0	0
KCNH5	27133	broad.mit.edu	37	14	63453898	63453898	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:63453898C>T	ENST00000322893.7	-	5	709	c.441G>A	c.(439-441)acG>acA	p.T147T	KCNH5_ENST00000420622.2_Silent_p.T147T|KCNH5_ENST00000394968.1_Silent_p.T89T|KCNH5_ENST00000394964.2_Silent_p.T89T	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	147					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		GGGCAAATTTCGTCCAACCTT	0.388000													8	26					0	0	0.000157383	0	0
GBA3	57733	broad.mit.edu	37	4	22749597	22749597	+	RNA	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:22749597G>A	ENST00000508166.1	+	0	1067				GBA3_ENST00000503442.1_RNA|GBA3_ENST00000511446.1_RNA	NM_020973.4	NP_066024.1	Q9H227	GBA3_HUMAN	glucosidase, beta, acid 3 (gene/pseudogene)						glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity			breast(1)|kidney(2)|large_intestine(4)|lung(20)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						AACAAGAAAGGAGAACTAGGT	0.383000													5	18					0	0	1.23904e-05	0	0
FBXW9	84261	broad.mit.edu	37	19	12800923	12800923	+	Splice_Site	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:12800923G>A	ENST00000393261.3	-	6	946	c.883_splice	c.e6-1	p.A295_splice	FBXW9_ENST00000587955.1_Silent_p.A315A|FBXW9_ENST00000544494.1_Splice_Site_p.A33_splice|FBXW9_ENST00000380339.3_Silent_p.A325A	NM_032301.2	NP_115677.2	Q5XUX1	FBXW9_HUMAN	F-box and WD repeat domain containing 9	325							protein binding			cervix(1)|lung(4)|ovary(1)|prostate(1)	7						GGGCTGGGCCGGCTTCATGGG	0.637000													25	55					0	0	9.22233e-05	0	0
PROCR	10544	broad.mit.edu	37	20	33764014	33764014	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr20:33764014C>T	ENST00000216968.4	+	3	448	c.366C>T	c.(364-366)ccC>ccT	p.P122P	EDEM2_ENST00000540582.1_Intron	NM_006404.3	NP_006395.2	Q9UNN8	EPCR_HUMAN	protein C receptor, endothelial	122					antigen processing and presentation|blood coagulation|immune response	integral to plasma membrane|MHC class I protein complex	receptor activity			breast(1)|kidney(2)|large_intestine(1)|lung(4)|prostate(1)|upper_aerodigestive_tract(1)	10			BRCA - Breast invasive adenocarcinoma(18;0.0152)		Drotrecogin alfa(DB00055)	AGCTGCCTCCCGAGGGCTCTA	0.612000													21	137					0	0	9.22233e-05	0	0
PRICKLE1	144165	broad.mit.edu	37	12	42853782	42853782	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:42853782T>G	ENST00000455697.1	-	8	2610	c.2325A>C	c.(2323-2325)gaA>gaC	p.E775D	RP11-328C8.4_ENST00000547824.1_RNA|PRICKLE1_ENST00000445766.2_Missense_Mutation_p.E775D|PRICKLE1_ENST00000552240.1_Missense_Mutation_p.E775D|PRICKLE1_ENST00000345127.3_Missense_Mutation_p.E775D|PRICKLE1_ENST00000548696.1_Missense_Mutation_p.E775D	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	775					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		GAAAATATCCTTCTTCTTCCG	0.517000													26	36					0	0	7.16444e-05	0	0
DIDO1	11083	broad.mit.edu	37	20	61525514	61525514	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr20:61525514G>A	ENST00000266070.4	-	12	2930	c.2605C>T	c.(2605-2607)Ccg>Tcg	p.P869S	DIDO1_ENST00000395343.1_Missense_Mutation_p.P869S|DIDO1_ENST00000395340.1_Missense_Mutation_p.P869S|DIDO1_ENST00000395335.2_Missense_Mutation_p.P869S	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	869					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					TGTTTTTTCGGAGCTGGCTCA	0.502000													42	176					0	0	0.000147903	0	0
KRT34	3885	broad.mit.edu	37	17	39537356	39537356	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:39537356C>T	ENST00000394001.1	-	3	696	c.666G>A	c.(664-666)gtG>gtA	p.V222V		NM_021013.3	NP_066293.2	O76011	KRT34_HUMAN	keratin 34	222	Coil 1B.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Breast(137;0.000496)				TCAGGGACTCCACCTGGGACT	0.537000													15	110					0	0	7.07596e-05	0	0
PLB1	151056	broad.mit.edu	37	2	28865849	28865849	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:28865849C>T	ENST00000422425.2	+	57	4310	c.4266C>T	c.(4264-4266)atC>atT	p.I1422I	PLB1_ENST00000541605.1_Silent_p.I398I|AC074011.2_ENST00000431376.1_RNA|PLB1_ENST00000327757.5_Silent_p.I1433I	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	1433	Necessary for membrane localization (By similarity).				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					TGGGCATCATCGGGACAGTGG	0.662000													7	16					0	0	0.000157383	0	0
SOWAHC	65124	broad.mit.edu	37	2	110373044	110373044	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:110373044C>T	ENST00000356454.3	+	1	1134	c.978C>T	c.(976-978)aaC>aaT	p.N326N		NM_023016.3	NP_075392.2	Q53LP3	ANR57_HUMAN	sosondowah ankyrin repeat domain family member C	326																	ACTTCGCCAACAAACACCAGC	0.627000													21	50					0	0	5.49717e-05	0	0
FBXW9	84261	broad.mit.edu	37	19	12800924	12800924	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:12800924G>A	ENST00000380339.3	-	6	1010	c.974C>T	c.(973-975)gCc>gTc	p.A325V	FBXW9_ENST00000587955.1_Missense_Mutation_p.A315V|FBXW9_ENST00000393261.3_Splice_Site_p.A295_splice|FBXW9_ENST00000544494.1_Splice_Site_p.A33_splice			Q5XUX1	FBXW9_HUMAN	F-box and WD repeat domain containing 9	325							protein binding			cervix(1)|lung(4)|ovary(1)|prostate(1)	7						GGCTGGGCCGGCTTCATGGGT	0.637000													25	54					0	0	9.22233e-05	0	0
AOC4P	90586	broad.mit.edu	37	17	41020841	41020841	+	RNA	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:41020841G>A	ENST00000585538.1	+	0	1680					NR_002773.1																						GCACACCCTGGGCACGGTCCA	0.567000													7	6					0	0	0.000157383	0	0
CFHR4	10877	broad.mit.edu	37	1	196887484	196887484	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:196887484C>T	ENST00000367416.2	+	10	1819	c.1682C>T	c.(1681-1683)tCa>tTa	p.S561L	CFHR4_ENST00000367418.1_Missense_Mutation_p.S315L|CFHR4_ENST00000251424.4_Missense_Mutation_p.S315L|CFHR2_ENST00000367421.3_Intron	NM_001201550.2|NM_001201551.1	NP_001188479.1|NP_001188480.1			complement factor H-related 4											NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	36						TCAGTTCTATCATTTCAAGCA	0.368000													12	23					0	0	0.000151284	0	0
SERINC3	10955	broad.mit.edu	37	20	43138550	43138550	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr20:43138550G>A	ENST00000342374.4	-	5	752	c.595C>T	c.(595-597)Cca>Tca	p.P199S	SERINC3_ENST00000255175.1_Missense_Mutation_p.P199S|SERINC3_ENST00000541235.1_Missense_Mutation_p.P144S	NM_006811.2	NP_006802.1	Q13530	SERC3_HUMAN	serine incorporator 3	199						integral to membrane|plasma membrane	protein binding			endometrium(4)|large_intestine(2)|lung(8)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(115;0.0122)	Colorectal(3;0.000291)|COAD - Colon adenocarcinoma(18;0.00189)			CACAACCTTGGGTTTCCTTCT	0.443000													49	55					0	0	0.000147903	0	0
CHAT	1103	broad.mit.edu	37	10	50856615	50856615	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:50856615C>T	ENST00000395562.2	+	10	1567	c.1098C>T	c.(1096-1098)atC>atT	p.I366I	CHAT_ENST00000337653.2_Silent_p.I448I|CHAT_ENST00000339797.1_Silent_p.I330I|CHAT_ENST00000395559.2_Silent_p.I330I|CHAT_ENST00000351556.3_Silent_p.I330I|CHAT_ENST00000455728.2_Silent_p.I330I	NM_001142933.1|NM_001142934.1	NP_001136405.1|NP_001136406.1	P28329	CLAT_HUMAN	choline O-acetyltransferase	448					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)|endometrium(2)|kidney(2)|large_intestine(11)|lung(34)|prostate(3)|urinary_tract(1)	56		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	TCGATGGCATCGTCCTGGTGC	0.607000													13	23					0	0	0.000219431	0	0
RXFP2	122042	broad.mit.edu	37	13	32363266	32363266	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr13:32363266G>A	ENST00000298386.2	+	14	1152	c.1081G>A	c.(1081-1083)Gaa>Aaa	p.E361K	RXFP2_ENST00000380314.1_Missense_Mutation_p.E337K	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	361						integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		CAGAGACCTGGAAAGGATAGA	0.343000													9	37					0	0	2.17888e-05	0	0
PLXNC1	10154	broad.mit.edu	37	12	94673364	94673364	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:94673364C>G	ENST00000258526.4	+	22	3963	c.3714C>G	c.(3712-3714)ttC>ttG	p.F1238L	RP11-1105G2.3_ENST00000551941.1_Intron|PLXNC1_ENST00000545312.1_5'UTR|PLXNC1_ENST00000547057.1_Missense_Mutation_p.F285L	NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	1238					axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						AAAAGATTTTCCAAGCATTCT	0.448000													19	90					0	0	0.000229342	0	0
THEMIS	387357	broad.mit.edu	37	6	128150713	128150713	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:128150713G>A	ENST00000368250.1	-	4	878	c.380C>T	c.(379-381)tCa>tTa	p.S127L	THEMIS_ENST00000543064.1_Missense_Mutation_p.S206L|THEMIS_ENST00000537166.1_Missense_Mutation_p.S171L|THEMIS_ENST00000368248.2_Missense_Mutation_p.S206L			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	206	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						CCACTTATTTGAAAAATCTGT	0.353000													32	36					0	0	0.000339439	0	0
KRT79	338785	broad.mit.edu	37	12	53216811	53216811	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:53216811G>A	ENST00000330553.5	-	7	1390	c.1356C>T	c.(1354-1356)agC>agT	p.S452S		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	452	Coil 2.|Rod.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						TGCTCTCCTCGCTCTCCAGAA	0.652000													10	29					0	0	0.00010058	0	0
TTLL6	284076	broad.mit.edu	37	17	46846367	46846367	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:46846367C>T	ENST00000393382.3	-	15	2801	c.2660G>A	c.(2659-2661)gGa>gAa	p.G887E	TTLL6_ENST00000433608.2_Missense_Mutation_p.G580E	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	839						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						CCTCTCACATCCTTTTTGGCC	0.498000													36	52					0	0	0.000270559	0	0
SMOC1	64093	broad.mit.edu	37	14	70442529	70442529	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:70442529C>T	ENST00000381280.4	+	4	729	c.476C>T	c.(475-477)tCa>tTa	p.S159L	SMOC1_ENST00000361956.3_Missense_Mutation_p.S159L	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1	159					cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		CCTGTATGTTCAGGTACCGTA	0.527000													9	19					0	0	3.86212e-05	0	0
MAPK15	225689	broad.mit.edu	37	8	144801635	144801635	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:144801635C>T	ENST00000338033.4	+	7	823	c.704C>T	c.(703-705)cCa>cTa	p.P235L	MAPK15_ENST00000395107.4_Missense_Mutation_p.P252L|MAPK15_ENST00000395108.2_Missense_Mutation_p.P235L	NM_139021.2	NP_620590.2	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	235	Protein kinase.				protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|stomach(1)	12	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GAGACCATCCCACCGCCATCT	0.657000													10	33					0	0	2.17888e-05	0	0
SOX21	11166	broad.mit.edu	37	13	95364222	95364222	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr13:95364222G>A	ENST00000376945.2	-	1	167	c.82C>T	c.(82-84)Cag>Tag	p.Q28*		NM_007084.2	NP_009015.1	Q9Y651	SOX21_HUMAN	SRY (sex determining region Y)-box 21	28					regulation of transcription from RNA polymerase II promoter|stem cell differentiation	nucleus	DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity			large_intestine(3)|lung(1)|prostate(1)|skin(1)	6	all_neural(89;0.0646)|Medulloblastoma(90;0.163)					GGGTTCTCCTGGGCCATCTTG	0.647000													8	23					0	0	0.000274275	0	0
DDX28	55794	broad.mit.edu	37	16	68056616	68056616	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr16:68056616G>A	ENST00000332395.5	-	1	1154	c.490C>T	c.(490-492)Cgc>Tgc	p.R164C		NM_018380.3	NP_060850.2	Q9NUL7	DDX28_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 28	164	Helicase ATP-binding.					mitochondrial nucleoid|nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	13		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0116)|Epithelial(162;0.0474)|all cancers(182;0.233)		TGGCGGCCGCGAAGTAGTGAG	0.642000													11	25					0	0	6.40141e-05	0	0
ATOH7	220202	broad.mit.edu	37	10	69991054	69991054	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:69991054C>T	ENST00000373673.3	-	1	817	c.381G>A	c.(379-381)gcG>gcA	p.A127A		NM_145178.3	NP_660161.1	Q8N100	ATOH7_HUMAN	atonal homolog 7 (Drosophila)	127					cell differentiation|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding										CCGGCAGCTTCGCGCCCGGGA	0.706000													6	23					0	0	8.12818e-05	0	0
TNS4	84951	broad.mit.edu	37	17	38640807	38640807	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:38640807G>A	ENST00000254051.6	-	6	1588	c.1430C>T	c.(1429-1431)tCt>tTt	p.S477F		NM_032865.5	NP_116254.4	Q8IZW8	TENS4_HUMAN	tensin 4	477	SH2.				apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	30		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			TCGGTATGAAGAGCTGTCCCT	0.582000													41	31					0	0	0.000437636	0	0
TBX2	6909	broad.mit.edu	37	17	59482937	59482937	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:59482937G>A	ENST00000240328.3	+	6	1707	c.1426G>A	c.(1426-1428)Ggg>Agg	p.G476R	RP11-332H18.4_ENST00000592009.1_RNA	NM_005994.3	NP_005985.3	Q13207	TBX2_HUMAN	T-box 2	476	Gly-rich.				cell aging|positive regulation of cell proliferation		sequence-specific DNA binding			endometrium(1)|lung(7)|ovary(1)	9						CCACTTGCACGGGCAGCAGTT	0.701000													6	25					0	0	0.000157383	0	0
DSCAM	1826	broad.mit.edu	37	21	41414391	41414391	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr21:41414391C>T	ENST00000400454.1	-	32	6070	c.5593G>A	c.(5593-5595)Gaa>Aaa	p.E1865K		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1865					cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding	p.E1865K(1)		NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				ATTCCCGATTCGGAAGGGGTG	0.537000													19	78					0	0	9.7654e-05	0	0
IL1F10	84639	broad.mit.edu	37	2	113832237	113832237	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:113832237C>T	ENST00000337569.3	+	3	131	c.56C>T	c.(55-57)cCt>cTt	p.P19L	IL1F10_ENST00000393197.2_Intron|IL1F10_ENST00000341010.2_Intron			Q8WWZ1	IL1FA_HUMAN	interleukin 1 family, member 10 (theta)	19						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			endometrium(1)|lung(6)|ovary(1)	8						GAGCCTTTACCTGCCAAGAGC	0.577000													35	71					0	0	0.000319135	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140750352	140750352	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr5:140750352C>T	ENST00000576222.1	+	1	522	c.391C>T	c.(391-393)Ccg>Tcg	p.P131S	PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGACAACCCACCGACCTTTAG	0.448000													70	80					0	0	0.000147903	0	0
HGFAC	3083	broad.mit.edu	37	4	3449240	3449240	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:3449240C>T	ENST00000382774.3	+	11	1492	c.1377C>T	c.(1375-1377)tcC>tcT	p.S459S	HGFAC_ENST00000511533.1_Silent_p.S466S	NM_001528.2	NP_001519.1	Q04756	HGFA_HUMAN	HGF activator	459	Peptidase S1.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		ACAGCGTCTCCGTGGTGCTGG	0.662000													30	70					0	0	0.000227799	0	0
SLC6A13	6540	broad.mit.edu	37	12	369146	369146	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:369146C>T	ENST00000343164.4	-	2	125	c.73G>A	c.(73-75)Gag>Aag	p.E25K	SLC6A13_ENST00000445055.2_Missense_Mutation_p.E25K|SLC6A13_ENST00000436453.1_Missense_Mutation_p.E25K	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	25				Missing (in Ref. 1; AAF64247).	neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			CCATCTTCCTCCTTCTTTTCC	0.522000													24	90					0	0	0.000117367	0	0
KEL	3792	broad.mit.edu	37	7	142650956	142650956	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:142650956G>A	ENST00000355265.2	-	9	1486	c.1012C>T	c.(1012-1014)Cat>Tat	p.H338Y	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	338					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					TCCACGTCATGGACCACGAGG	0.537000													43	61					0	0	8.96297e-05	0	0
NCKAP5	344148	broad.mit.edu	37	2	133539526	133539526	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:133539526C>T	ENST00000409261.1	-	14	5231	c.4858G>A	c.(4858-4860)Gaa>Aaa	p.E1620K	NCKAP5_ENST00000473859.1_5'UTR|NCKAP5_ENST00000409213.1_Intron|NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000317721.6_Missense_Mutation_p.E1620K	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1620							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TTCAAGAGTTCCGTCATGAAG	0.448000													46	65					0	0	0.000147903	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41450752	41450752	+	RNA	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:41450752C>T	ENST00000599198.1	+	0	1343					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						ATCCCCTTCTCCTTAGGTAAG	0.458000													12	72					0	0	0.000308642	0	0
NR4A2	4929	broad.mit.edu	37	2	157183340	157183340	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:157183340G>A	ENST00000339562.4	-	6	1613	c.1251C>T	c.(1249-1251)atC>atT	p.I417I	NR4A2_ENST00000409108.2_Silent_p.I417I|NR4A2_ENST00000426264.1_Silent_p.I354I|NR4A2_ENST00000409572.1_Silent_p.I417I|NR4A2_ENST00000429376.1_Silent_p.I354I|NR4A2_ENST00000539077.1_Silent_p.I428I	NM_006186.3	NP_006177.1	P43354	NR4A2_HUMAN	nuclear receptor subfamily 4, group A, member 2	417	Ligand-binding (Potential).				cellular response to extracellular stimulus|dopaminergic neuron differentiation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus	nucleoplasm	sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			breast(3)|endometrium(4)|kidney(1)|large_intestine(7)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	40						CCCAGCCCCGGATGATCTCCA	0.502000													60	158					0	0	0.000147903	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43826523	43826523	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:43826523C>T	ENST00000389420.3	-	20	2811	c.2812G>A	c.(2812-2814)Gaa>Aaa	p.E938K	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.E938K|ADAMTS20_ENST00000395541.2_Missense_Mutation_p.E92K	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	938	TSP type-1 3.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		GTCTGTCCTTCATGAATGGAA	0.423000													25	44					0	0	9.22233e-05	0	0
RP1	6101	broad.mit.edu	37	8	55537354	55537354	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:55537354G>A	ENST00000220676.1	+	4	1060	c.912G>A	c.(910-912)aaG>aaA	p.K304K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	304					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CCTTAGAAAAGAATGATTCTC	0.318000													5	58					0	0	3.59834e-05	0	0
THOC6	79228	broad.mit.edu	37	16	3076282	3076282	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr16:3076282C>T	ENST00000326266.8	+	5	651	c.355C>T	c.(355-357)Cca>Tca	p.P119S	THOC6_ENST00000574549.1_Missense_Mutation_p.P95S|THOC6_ENST00000575576.1_Missense_Mutation_p.P95S|THOC6_ENST00000253952.9_Missense_Mutation_p.P119S	NM_024339.3	NP_077315.2	Q86W42	THOC6_HUMAN	THO complex 6 homolog (Drosophila)	119					intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	RNA binding			central_nervous_system(1)|endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	13						TCGTCAGCCTCCATACAGGTG	0.577000													5	40					0	0	0.000157383	0	0
ADAM18	8749	broad.mit.edu	37	8	39442147	39442147	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:39442147C>T	ENST00000265707.5	+	1	51	c.6C>T	c.(4-6)ttC>ttT	p.F2F	ADAM18_ENST00000379866.1_Silent_p.F2F|ADAM18_ENST00000541111.1_5'UTR|ADAM18_ENST00000520772.1_Silent_p.F2F	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	2					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			GAGCCATGTTCCTTCTCCTCG	0.627000													26	38					0	0	0.000109025	0	0
DCAF4	26094	broad.mit.edu	37	14	73404716	73404716	+	Translation_Start_Site	SNP	A	A	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:73404716A>T	ENST00000553457.1	+	0	20				DCAF4_ENST00000555042.1_Missense_Mutation_p.R10S|DCAF4_ENST00000510612.1_3'UTR|DCAF4_ENST00000509153.1_Missense_Mutation_p.R10S|DCAF4_ENST00000394234.2_Intron|DCAF4_ENST00000358377.2_Missense_Mutation_p.R10S|DCAF4_ENST00000353777.3_Missense_Mutation_p.R10S			Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4							CUL4 RING ubiquitin ligase complex				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|skin(1)	22						AGAGTAGAAGACGACATGGGA	0.478000													56	119					0	0	0.000147903	0	0
CXCL6	6372	broad.mit.edu	37	4	74702991	74702991	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:74702991A>T	ENST00000226317.5	+	3	568	c.314A>T	c.(313-315)aAa>aTa	p.K105I	CXCL6_ENST00000515050.1_Missense_Mutation_p.K105I|CXCL6_ENST00000503446.1_3'UTR	NM_002993.3	NP_002984.1	P80162	CXCL6_HUMAN	chemokine (C-X-C motif) ligand 6	105					cell-cell signaling|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding			large_intestine(1)|lung(7)	8	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			GTCATCCAGAAAATTTTGGAC	0.403000													19	55					0	0	0.000295444	0	0
ZNF184	7738	broad.mit.edu	37	6	27419241	27419241	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:27419241G>A	ENST00000211936.6	-	6	2381	c.2097C>T	c.(2095-2097)aaC>aaT	p.N699N	ZNF184_ENST00000377419.1_Silent_p.N699N	NM_007149.2	NP_009080.2	Q99676	ZN184_HUMAN	zinc finger protein 184	699					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|kidney(9)|large_intestine(13)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	48						ATTCATTACAGTTATAAGGTT	0.413000													19	47					0	0	0.000132079	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													5	56					0	0	3.59834e-05	0	0
BTNL8	79908	broad.mit.edu	37	5	180335889	180335889	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr5:180335889C>T	ENST00000231229.4	+	2	587	c.353C>T	c.(352-354)tCc>tTc	p.S118F	BTNL8_ENST00000508408.1_Missense_Mutation_p.S118F|BTNL8_ENST00000511704.1_Intron|BTNL8_ENST00000340184.4_Missense_Mutation_p.S118F|BTNL8_ENST00000400707.3_Intron	NM_001159708.1|NM_024850.2	NP_001153180.1|NP_079126.1	Q6UX41	BTNL8_HUMAN	butyrophilin-like 8	118	Ig-like V-type 1.					integral to membrane				breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(12)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	28	all_cancers(89;3.37e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGGATTAGTTCCCAGTCTTAC	0.463000													136	202					0	0	0.000147903	0	0
MUC6	4588	broad.mit.edu	37	11	1019476	1019476	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:1019476C>T	ENST00000421673.2	-	30	3879	c.3829G>A	c.(3829-3831)Gcc>Acc	p.A1277T		NM_005961.2	NP_005952.2	Q6W4X9	MUC6_HUMAN	mucin 6, oligomeric mucus/gel-forming	1277	Pro-rich.|Thr-rich.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(8)|kidney(10)|large_intestine(6)|lung(43)|ovary(4)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	80		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGGGTGACGGCCGTGGTTGGT	0.642000													26	114					0	0	9.22233e-05	0	0
PIK3C2A	5286	broad.mit.edu	37	11	17140817	17140817	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:17140817C>T	ENST00000265970.7	-	16	2889	c.2890G>A	c.(2890-2892)Gag>Aag	p.E964K	PIK3C2A_ENST00000540361.1_Missense_Mutation_p.E584K|PIK3C2A_ENST00000531428.1_Intron	NM_002645.2	NP_002636.2	O00443	P3C2A_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha	964					cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			central_nervous_system(4)|endometrium(5)|kidney(5)|large_intestine(7)|lung(24)|ovary(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	58					Phosphatidylserine(DB00144)	CTAATGGCCTCAATCCAGGTC	0.378000													21	65					0	0	0.000295444	0	0
RBM25	58517	broad.mit.edu	37	14	73581037	73581037	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:73581037C>T	ENST00000261973.7	+	18	2720	c.2435C>T	c.(2434-2436)gCc>gTc	p.A812V	RBM25_ENST00000532483.1_3'UTR|RBM25_ENST00000527432.1_Missense_Mutation_p.A812V	NM_021239.2	NP_067062.1	P49756	RBM25_HUMAN	RNA binding motif protein 25	812	PWI.				apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(6)|ovary(2)|pancreas(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		GATGATGTTGCCATGGTAAGT	0.279000													70	194					0	0	0.000147903	0	0
KALRN	8997	broad.mit.edu	37	3	124420920	124420920	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:124420920G>A	ENST00000360013.3	+	57	8159	c.8032G>A	c.(8032-8034)Gaa>Aaa	p.E2678K	KALRN_ENST00000291478.4_Missense_Mutation_p.E981K|KALRN_ENST00000428018.2_Missense_Mutation_p.E949K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2677					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TTCTTGGAAGGAAAATTTTGA	0.358000													18	50					0	0	0.000229342	0	0
OGDHL	55753	broad.mit.edu	37	10	50944148	50944148	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:50944148C>T	ENST00000374103.4	-	22	2915	c.2830G>A	c.(2830-2832)Gag>Aag	p.E944K	OGDHL_ENST00000432695.1_Missense_Mutation_p.E735K|OGDHL_ENST00000490844.1_5'UTR|OGDHL_ENST00000419399.1_Missense_Mutation_p.E887K	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	944					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						TTGTGCTCCTCCTGACACCAG	0.577000													12	23					0	0	6.40141e-05	0	0
GRPEL1	80273	broad.mit.edu	37	4	7062907	7062907	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:7062907C>T	ENST00000264954.4	-	4	500	c.336G>A	c.(334-336)ttG>ttA	p.L112L	GRPEL1_ENST00000514056.1_5'UTR	NM_025196.2	NP_079472.1	Q9HAV7	GRPE1_HUMAN	GrpE-like 1, mitochondrial (E. coli)	112					protein folding|protein import into mitochondrial matrix	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)	5						CTGCCACCTCCAACAAGTCCT	0.473000													47	113					0	0	0.000147903	0	0
AKT2	208	broad.mit.edu	37	19	40743886	40743886	+	Missense_Mutation	SNP	C	C	G	rs121434593		TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:40743886C>G	ENST00000392038.2	-	9	1119	c.821G>C	c.(820-822)cGc>cCc	p.R274P	AKT2_ENST00000579047.1_Missense_Mutation_p.R212P|AKT2_ENST00000424901.1_Missense_Mutation_p.R274P|AKT2_ENST00000311278.6_Missense_Mutation_p.R274P	NM_001243027.1|NM_001243028.1|NM_001626.4	NP_001229956.1|NP_001229957.1|NP_001617.1	P31751	AKT2_HUMAN	v-akt murine thymoma viral oncogene homolog 2	274	Protein kinase.				insulin receptor signaling pathway|negative regulation of plasma membrane long-chain fatty acid transport|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process	cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(1)|cervix(1)|kidney(3)|large_intestine(9)|lung(10)|prostate(2)|skin(1)	27			Lung(22;0.000499)			CTTGATGTCGCGGTATACCAC	0.597000			A		"""ovarian, pancreatic """								36	63					0	0	0.000191422	0	0
SLC45A4	57210	broad.mit.edu	37	8	142229076	142229076	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:142229076G>A	ENST00000519067.1	-	4	813	c.510C>T	c.(508-510)acC>acT	p.T170T	SLC45A4_ENST00000433583.2_Silent_p.T163T|SLC45A4_ENST00000024061.3_Silent_p.T170T|SLC45A4_ENST00000517878.1_Silent_p.T221T			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	221					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TGCCCAGGAAGGTCTGGGTCC	0.657000													11	75					0	0	0.000219431	0	0
DUXA	503835	broad.mit.edu	37	19	57666693	57666693	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:57666693C>T	ENST00000554048.2	-	5	485	c.486G>A	c.(484-486)agG>agA	p.R162R		NM_001012729.1	NP_001012747.1	A6NLW8	DUXA_HUMAN	double homeobox A	162						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)	17		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0123)		CCACAGGTTCCCTTTTTCTCT	0.413000													13	70					0	0	5.01169e-05	0	0
SCN9A	6335	broad.mit.edu	37	2	167162385	167162385	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:167162385G>A	ENST00000375387.4	-	5	856	c.516C>T	c.(514-516)atC>atT	p.I172I	SCN9A_ENST00000409672.1_Silent_p.I171I|SCN9A_ENST00000303354.6_Silent_p.I172I|SCN9A_ENST00000409435.1_Silent_p.I171I			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	171						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	CTCTTGCAAGGATTTTTACAA	0.378000													16	45					0	0	0.000308642	0	0
COL22A1	169044	broad.mit.edu	37	8	139833559	139833559	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:139833559C>T	ENST00000303045.6	-	7	1511	c.1065G>A	c.(1063-1065)cgG>cgA	p.R355R	COL22A1_ENST00000435777.1_Silent_p.R355R	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	355	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GGTCATTGACCCGAGAACCTC	0.577000										HNSCC(7;0.00092)			10	30					0	0	3.86212e-05	0	0
DNAH10	196385	broad.mit.edu	37	12	124330613	124330613	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:124330613C>T	ENST00000409039.3	+	31	5397	c.5372C>T	c.(5371-5373)aCc>aTc	p.T1791I		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1791	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TGCACGGGAACCTTTGGCTAC	0.592000													28	63					0	0	0.000279167	0	0
XKR4	114786	broad.mit.edu	37	8	56436558	56436558	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:56436558G>A	ENST00000327381.5	+	3	1825	c.1725G>A	c.(1723-1725)gtG>gtA	p.V575V		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	575						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			TCTTTCAAGTGAGGCCCACTG	0.532000													28	42					0	0	0.000147802	0	0
OR7D4	125958	broad.mit.edu	37	19	9325039	9325039	+	Missense_Mutation	SNP	G	G	A	rs140587334		TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:9325039G>A	ENST00000308682.2	-	1	503	c.475C>T	c.(475-477)Cat>Tat	p.H159Y		NM_001005191.2	NP_001005191.1	Q8NG98	OR7D4_HUMAN	olfactory receptor, family 7, subfamily D, member 4	159					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.H159Y(1)		breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(2)|skin(3)|stomach(1)	26						AGTAGAATATGAACCAGGGAG	0.522000													14	32					0	0	0.000151284	0	0
ACTC1	70	broad.mit.edu	37	15	35084474	35084474	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr15:35084474C>T	ENST00000290378.4	-	5	1280	c.625G>A	c.(625-627)Gaa>Aaa	p.E209K	RP11-814P5.1_ENST00000503496.1_RNA|ACTC1_ENST00000557860.1_5'UTR	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1	209					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	31		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		CGGACAATTTCACGTTCAGCT	0.468000													19	33					0	0	0.000229342	0	0
OR4K5	79317	broad.mit.edu	37	14	20389533	20389533	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:20389533C>T	ENST00000315915.4	+	1	793	c.768C>T	c.(766-768)ttC>ttT	p.F256F		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CTTGCATCTTCATCTATGTGT	0.398000													21	55					0	0	0.000375601	0	0
XDH	7498	broad.mit.edu	37	2	31573079	31573079	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:31573079C>T	ENST00000379416.3	-	25	2690	c.2642G>A	c.(2641-2643)cGa>cAa	p.R881Q		NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	881					purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity	p.R881Q(1)		breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	GAATAAAGCTCGTTCCATAAT	0.498000													7	29					0	0	8.12818e-05	0	0
USP43	124739	broad.mit.edu	37	17	9632267	9632267	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:9632267C>T	ENST00000570827.2	+	15	3473	c.2399C>T	c.(2398-2400)tCt>tTt	p.S800F	USP43_ENST00000285199.6_Missense_Mutation_p.S1111F|USP43_ENST00000570475.1_Missense_Mutation_p.S1106F			Q70EL4	UBP43_HUMAN	ubiquitin specific peptidase 43	1111					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	26						CACACTCTTTCTTTAGGTCGA	0.507000											OREG0024168	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	154					0	0	0.000339439	0	0
PRKCZ	5590	broad.mit.edu	37	1	2103786	2103786	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:2103786C>T	ENST00000400921.2	+	10	1378	c.695C>T	c.(694-696)cCg>cTg	p.P232L	PRKCZ_ENST00000400920.1_Missense_Mutation_p.P232L|PRKCZ_ENST00000479263.1_3'UTR	NM_001033581.1	NP_001028753.1	Q05513	KPCZ_HUMAN	protein kinase C, zeta	415					anti-apoptosis|intracellular signal transduction|negative regulation of insulin receptor signaling pathway|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein complex assembly|peptidyl-serine phosphorylation|platelet activation	endosome	ATP binding|protein kinase C activity|zinc ion binding			breast(2)|central_nervous_system(4)|endometrium(1)|large_intestine(5)|lung(5)|stomach(1)	18	all_cancers(77;0.000177)|all_epithelial(69;6.41e-05)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;1.14e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.96e-37)|OV - Ovarian serous cystadenocarcinoma(86;3.3e-23)|GBM - Glioblastoma multiforme(42;2.85e-08)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.00294)|BRCA - Breast invasive adenocarcinoma(365;0.00493)|STAD - Stomach adenocarcinoma(132;0.00669)|KIRC - Kidney renal clear cell carcinoma(229;0.0411)|Lung(427;0.213)		TGCGGAACCCCGAATTACATC	0.637000													8	14					0	0	3.86212e-05	0	0
IGSF1	3547	broad.mit.edu	37	X	130419794	130419794	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:130419794C>T	ENST00000370904.1	-	10	1209	c.299G>A	c.(298-300)tGg>tAg	p.W100*	IGSF1_ENST00000361420.3_Nonsense_Mutation_p.W109*|IGSF1_ENST00000370900.1_Nonsense_Mutation_p.W109*|IGSF1_ENST00000370903.3_Nonsense_Mutation_p.W109*|IGSF1_ENST00000370910.1_Nonsense_Mutation_p.W100*|IGSF1_ENST00000370901.4_Nonsense_Mutation_p.W109*			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	109	Ig-like C2-type 1.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						TGTCTCCTTCCAGTAGCAGCA	0.498000													42	73					0	0	0.000437636	0	0
C1QTNF8	390664	broad.mit.edu	37	16	1144728	1144728	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr16:1144728G>A	ENST00000328449.5	-	3	468	c.195C>T	c.(193-195)atC>atT	p.I65I		NM_207419.3	NP_997302.2	P60827	C1QT8_HUMAN	C1q and tumor necrosis factor related protein 8	65						collagen				lung(2)|prostate(1)|skin(1)	4		Hepatocellular(780;0.00369)				TGAGGATTTCGATGTCTATAG	0.672000													18	15					0	0	9.7654e-05	0	0
ULK4	54986	broad.mit.edu	37	3	41860970	41860970	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:41860970C>G	ENST00000301831.4	-	19	2255	c.1793G>C	c.(1792-1794)tGc>tCc	p.C598S		NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	598							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		AACAGCCCAGCACTCTCTAGG	0.433000													10	17					0	0	0.000151284	0	0
OR8J3	81168	broad.mit.edu	37	11	55904804	55904804	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:55904804G>A	ENST00000301529.1	-	1	390	c.391C>T	c.(391-393)Ctc>Ttc	p.L131F		NM_001004064.1	NP_001004064.1	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J, member 3	131					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(1)|lung(38)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	59	Esophageal squamous(21;0.00693)					ACCATGTAGAGCAGAGGGTTA	0.502000													23	55					0	0	0.000375601	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110509266	110509266	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:110509266G>C	ENST00000378402.5	+	64	10550	c.10446G>C	c.(10444-10446)tgG>tgC	p.W3482C		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3482					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTACCATTTGGACATGCTGGG	0.338000										HNSCC(38;0.096)			26	81					0	0	5.49717e-05	0	0
NCAPH	23397	broad.mit.edu	37	2	97007508	97007508	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:97007508C>T	ENST00000455200.1	+	2	410	c.115C>T	c.(115-117)Cca>Tca	p.P39S	NCAPH_ENST00000427946.1_Intron|NCAPH_ENST00000240423.4_Missense_Mutation_p.P50S			Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	50					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Ovarian(717;0.0221)				TCCTGGCACCCCAGTCCTCGA	0.597000													28	66					0	0	0.000227799	0	0
EPHB1	2047	broad.mit.edu	37	3	134898763	134898763	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:134898763C>T	ENST00000398015.3	+	10	2191	c.1821C>T	c.(1819-1821)gtC>gtT	p.V607V	EPHB1_ENST00000493838.1_Silent_p.V168V	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	607						integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						ACGAAGCTGTCCGGGAGTTTG	0.483000													38	72					0	0	0.000228196	0	0
TNFRSF12A	51330	broad.mit.edu	37	16	3070469	3070469	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr16:3070469C>T	ENST00000575124.1	+	1	94	c.71C>T	c.(70-72)tCc>tTc	p.S24F	TNFRSF12A_ENST00000573001.1_Intron|TNFRSF12A_ENST00000326577.4_Missense_Mutation_p.S24F|TNFRSF12A_ENST00000341627.5_Missense_Mutation_p.S24F			Q9NP84	TNR12_HUMAN	tumor necrosis factor receptor superfamily, member 12A	24					angiogenesis|apoptosis	integral to membrane	receptor activity			lung(1)|skin(1)	2						TTGCTGCGCTCCGTGGCCGGG	0.746000													4	17					0	0	0.00024832	0	0
RADIL	55698	broad.mit.edu	37	7	4841434	4841434	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr7:4841434C>T	ENST00000399583.3	-	12	2879	c.2692G>A	c.(2692-2694)Gac>Aac	p.D898N	RADIL_ENST00000536091.1_3'UTR|RADIL_ENST00000538469.1_Missense_Mutation_p.D658N	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	898	Pro-rich.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CAGGACGAGTCCGTGTGCGGG	0.721000													10	16					0	0	0.000219431	0	0
ANK3	288	broad.mit.edu	37	10	61834169	61834169	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:61834169G>A	ENST00000280772.1	-	37	6661	c.6470C>T	c.(6469-6471)cCc>cTc	p.P2157L	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2157					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						AGGAGGGATGGGAACTTCATG	0.483000													4	18					0	0	0.00024832	0	0
PLEC	5339	broad.mit.edu	37	8	144993494	144993494	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:144993494T>C	ENST00000322810.4	-	32	11075	c.10906A>G	c.(10906-10908)Aac>Gac	p.N3636D	PLEC_ENST00000356346.3_Missense_Mutation_p.N3485D|PLEC_ENST00000357649.2_Missense_Mutation_p.N3503D|PLEC_ENST00000398774.2_Missense_Mutation_p.N3467D|PLEC_ENST00000436759.2_Missense_Mutation_p.N3526D|PLEC_ENST00000354958.2_Missense_Mutation_p.N3477D|PLEC_ENST00000345136.3_Missense_Mutation_p.N3499D|PLEC_ENST00000527096.1_Missense_Mutation_p.N3522D|PLEC_ENST00000354589.3_Missense_Mutation_p.N3499D	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3636	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						AGGACGCGGTTCATCTCCTCA	0.657000													28	64					0	0	0.000117367	0	0
FCGBP	8857	broad.mit.edu	37	19	40421209	40421209	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:40421209C>T	ENST00000221347.6	-	5	2719	c.2712G>A	c.(2710-2712)cgG>cgA	p.R904R		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	904	VWFD 2.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCACCAGCACCCGGAAGGCAG	0.682000													4	19					0	0	0.00024832	0	0
MUC16	94025	broad.mit.edu	37	19	9073985	9073985	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:9073985G>A	ENST00000397910.4	-	3	13664	c.13461C>T	c.(13459-13461)acC>acT	p.T4487T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4489	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCAGTCCAGAGGTAAGAACTG	0.458000													10	14					0	0	0.000219431	0	0
ARSD	414	broad.mit.edu	37	X	2825553	2825553	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:2825553G>A	ENST00000381154.1	-	10	1616	c.1541C>T	c.(1540-1542)cCt>cTt	p.P514L		NM_001669.3	NP_001660.2	P51689	ARSD_HUMAN	arylsulfatase D	514						lysosome	arylsulfatase activity|metal ion binding			large_intestine(3)|lung(3)	6		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				AAAGAGCAAAGGGGGTCTGTG	0.692000													4	11					0	0	1.23904e-05	0	0
KCNK10	54207	broad.mit.edu	37	14	88654351	88654351	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:88654351C>T	ENST00000340700.5	-	6	1407	c.956G>A	c.(955-957)gGa>gAa	p.G319E	KCNK10_ENST00000312350.5_Missense_Mutation_p.G324E|KCNK10_ENST00000319231.5_Missense_Mutation_p.G324E	NM_021161.4	NP_066984.1	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	319					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						TAGCCAATCTCCGATCATACT	0.478000													75	110					0	0	0.000147903	0	0
AFM	173	broad.mit.edu	37	4	74351594	74351594	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:74351594G>A	ENST00000226355.3	+	4	379	c.286G>A	c.(286-288)Gaa>Aaa	p.E96K		NM_001133.2	NP_001124.1	P43652	AFAM_HUMAN	afamin	96	Albumin 1.				vitamin transport		vitamin E binding			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	Breast(15;0.00102)		Epithelial(6;5.69e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|all cancers(17;0.000555)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			TGTTTTACAGGAAAAAATATG	0.348000													6	25					0	0	8.12818e-05	0	0
AK7	122481	broad.mit.edu	37	14	96949417	96949417	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:96949417G>A	ENST00000267584.4	+	16	1879	c.1835G>A	c.(1834-1836)gGt>gAt	p.G612D		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	612					cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		CGAAATTATGGTTTAACAGAC	0.507000													56	112					0	0	0.000147903	0	0
CASS4	57091	broad.mit.edu	37	20	55012333	55012333	+	Silent	SNP	T	T	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr20:55012333T>C	ENST00000371336.3	+	2	351	c.150T>C	c.(148-150)ggT>ggC	p.G50G	CASS4_ENST00000360314.3_Silent_p.G50G|CASS4_ENST00000434344.1_Silent_p.G50G	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	50	SH3.				cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						AAAGCGAGGGTTGGTGGAAGT	0.607000													41	58					0	0	0.000147903	0	0
RCE1	9986	broad.mit.edu	37	11	66613398	66613398	+	Silent	SNP	G	G	A	rs139646297		TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr11:66613398G>A	ENST00000309657.3	+	8	866	c.822G>A	c.(820-822)gcG>gcA	p.A274A	RCE1_ENST00000524506.1_Silent_p.A253A|RCE1_ENST00000525356.1_Silent_p.A151A	NM_001032279.1|NM_005133.2	NP_001027450.1|NP_005124.1	Q9Y256	FACE2_HUMAN	Ras converting CAAX endopeptidase 1	274					proteolysis	endoplasmic reticulum membrane|integral to plasma membrane	metalloendopeptidase activity			breast(2)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	10						CTGTTTGCGCGGCCTTGGAGC	0.617000													12	73					0	0	0.000151284	0	0
EXTL1	2134	broad.mit.edu	37	1	26360198	26360198	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:26360198C>T	ENST00000374280.3	+	9	2397	c.1530C>T	c.(1528-1530)gcC>gcT	p.A510A		NM_004455.2	NP_004446.2	Q92935	EXTL1_HUMAN	exostosin-like glycosyltransferase 1	510					skeletal system development	integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|stomach(1)|urinary_tract(1)	23		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;6.44e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|BRCA - Breast invasive adenocarcinoma(304;0.000954)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00594)|READ - Rectum adenocarcinoma(331;0.0649)		TGGACTTTGCCTTTCTGGTGT	0.597000													70	144					0	0	0.000147903	0	0
PTGFR	5737	broad.mit.edu	37	1	78958726	78958726	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:78958726C>T	ENST00000370756.3	+	2	535	c.298C>T	c.(298-300)Cgc>Tgc	p.R100C	PTGFR_ENST00000370757.3_Missense_Mutation_p.R100C|PTGFR_ENST00000370758.1_Missense_Mutation_p.R100C	NM_001039585.1	NP_001034674.1	P43088	PF2R_HUMAN	prostaglandin F receptor (FP)	100					parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			breast(6)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	33				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	AGAATGGATCCGCTTTGACCA	0.443000													54	122					0	0	0.000147903	0	0
AOC3	8639	broad.mit.edu	37	17	41004022	41004022	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:41004022G>A	ENST00000308423.2	+	1	822	c.662G>A	c.(661-663)gGg>gAg	p.G221E		NM_003734.2	NP_003725.1	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3	221					amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			breast(1)|central_nervous_system(4)|endometrium(4)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|skin(8)	41		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	CTGCAATCAGGGGACCGGGCC	0.612000													6	36					0	0	8.12818e-05	0	0
STYK1	55359	broad.mit.edu	37	12	10783853	10783853	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:10783853C>T	ENST00000075503.3	-	5	762	c.242G>A	c.(241-243)gGa>gAa	p.G81E		NM_018423.2	NP_060893.2	Q6J9G0	STYK1_HUMAN	serine/threonine/tyrosine kinase 1	81						integral to membrane|plasma membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|liver(1)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	26						AGCCACATTTCCTCCATGTCC	0.557000										HNSCC(73;0.22)			32	49					0	0	0.000109025	0	0
ACTL6A	86	broad.mit.edu	37	3	179287645	179287645	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:179287645C>T	ENST00000429709.2	+	2	272	c.59C>T	c.(58-60)tCc>tTc	p.S20F	ACTL6A_ENST00000392662.1_5'UTR|ACTL6A_ENST00000450518.2_5'UTR	NM_004301.3	NP_004292.1	O96019	ACL6A_HUMAN	actin-like 6A	20					chromatin remodeling|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|nervous system development|regulation of growth|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	Ino80 complex|npBAF complex|NuA4 histone acetyltransferase complex|plasma membrane|SWI/SNF complex	ATP binding|chromatin binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|urinary_tract(1)	21	all_cancers(143;3.94e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.98e-26)|GBM - Glioblastoma multiforme(14;0.0169)			GACATTGGATCCTATACTGTG	0.353000													47	66					0	0	0.000147903	0	0
RP1	6101	broad.mit.edu	37	8	55541396	55541396	+	Missense_Mutation	SNP	C	C	T	rs151328121	byFrequency	TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:55541396C>T	ENST00000220676.1	+	4	5102	c.4954C>T	c.(4954-4956)Cgc>Tgc	p.R1652C		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1652			R -> L (in RP1; uncertain pathogenicity).		axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGGGTCTACCCGCAAATCTCA	0.373000													37	64					0	0	0.000132358	0	0
DDX51	317781	broad.mit.edu	37	12	132627336	132627336	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:132627336G>A	ENST00000397333.3	-	3	645	c.607C>T	c.(607-609)Cct>Tct	p.P203S		NM_175066.3	NP_778236.2	Q8N8A6	DDX51_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51	203					rRNA processing	nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			endometrium(1)|lung(5)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.59e-08)|Epithelial(86;3.62e-07)|all cancers(50;2.13e-05)		TGGACGTCAGGGATGTCCTCG	0.592000													19	127					0	0	0.000229342	0	0
FAT4	79633	broad.mit.edu	37	4	126411726	126411726	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:126411726C>T	ENST00000394329.3	+	17	13762	c.13749C>T	c.(13747-13749)atC>atT	p.I4583I	FAT4_ENST00000335110.5_Silent_p.I2824I	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4583					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AACCAGATATCATTGAAAGGG	0.478000													11	64					0	0	3.86212e-05	0	0
UGT2B4	7363	broad.mit.edu	37	4	70350966	70350966	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:70350966C>T	ENST00000305107.6	-	5	1316	c.1270G>A	c.(1270-1272)Gac>Aac	p.D424N	UGT2B4_ENST00000506580.1_Intron|UGT2B4_ENST00000381096.3_Missense_Mutation_p.D288N|UGT2B4_ENST00000512583.1_Intron	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	424					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						TTGAGTAAGTCTGTACTCGAC	0.413000													8	38					0	0	2.17888e-05	0	0
SEPT9	10801	broad.mit.edu	37	17	75398448	75398448	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:75398448C>T	ENST00000329047.8	+	2	1142	c.330C>T	c.(328-330)tcC>tcT	p.S110S	SEPT9_ENST00000592420.1_5'UTR|SEPT9_ENST00000588690.1_5'UTR|SEPT9_ENST00000591198.1_Silent_p.S109S|SEPT9_ENST00000449803.2_5'UTR|SEPT9_ENST00000427674.2_5'UTR|SEPT9_ENST00000590294.1_Silent_p.S110S|SEPT9_ENST00000423034.2_Silent_p.S121S|SEPT9_ENST00000431235.2_5'UTR|SEPT9_ENST00000427177.1_Silent_p.S128S	NM_006640.4	NP_006631.2	Q9UHD8	SEPT9_HUMAN	septin 9	128					cell cycle|cell division|protein heterooligomerization	microtubule|perinuclear region of cytoplasm|stress fiber	GTP binding|GTPase activity|protein binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(2)	16			BRCA - Breast invasive adenocarcinoma(99;0.153)			TCGGCCCGTCCCGGTTCGGGC	0.682000													25	16					0	0	0.000184323	0	0
BCRP7	100133163	broad.mit.edu	37	22	18844763	18844763	+	RNA	SNP	T	T	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr22:18844763T>C	ENST00000412938.1	+	0	3013																											TCACAGCCTCTGAGGGCAGCA	0.562000													4	11					0	0	1.23904e-05	0	0
HTR7	3363	broad.mit.edu	37	10	92508946	92508946	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr10:92508946G>A	ENST00000371721.3	-	2	1187	c.945C>T	c.(943-945)aaC>aaT	p.N315N	HTR7_ENST00000336152.3_Silent_p.N315N|HTR7_ENST00000371719.2_Silent_p.N315N|HTR7_ENST00000277874.6_Silent_p.N315N			P34969	5HT7R_HUMAN	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	315					blood circulation|circadian rhythm	integral to plasma membrane	protein binding|serotonin receptor activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30					Eletriptan(DB00216)|Methysergide(DB00247)|Ziprasidone(DB00246)	AGATGGAGATGTTTTTCCTTT	0.527000													5	15					0	0	1.23904e-05	0	0
SPINK14	408187	broad.mit.edu	37	5	147549342	147549342	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr5:147549342T>A	ENST00000356972.1	+	1	47	c.47T>A	c.(46-48)aTa>aAa	p.I16K	SPINK14_ENST00000562793.1_Missense_Mutation_p.I16K	NM_001001325.1	NP_001001325.1	Q6IE38	ISK14_HUMAN	serine peptidase inhibitor, Kazal type 14 (putative)	16						extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|large_intestine(1)|lung(1)	3						TTTATCTTGATACATTTGGTG	0.388000													6	4					0	0	3.59834e-05	0	0
HCN4	10021	broad.mit.edu	37	15	73615110	73615110	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr15:73615110G>A	ENST00000261917.3	-	8	4317	c.3324C>T	c.(3322-3324)tcC>tcT	p.S1108S		NM_005477.2	NP_005468.1	Q9Y3Q4	HCN4_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 4	1108					blood circulation|muscle contraction	integral to membrane	cAMP binding|protein binding|sodium channel activity|voltage-gated potassium channel activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(13)|liver(1)|lung(18)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	55				COAD - Colon adenocarcinoma(1;0.142)		ACTCCCCTGAGGAGTGCGGGG	0.736000													3	6					0	0	6.4e-05	0	0
MST1L	11223	broad.mit.edu	37	1	17084327	17084327	+	RNA	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:17084327G>A	ENST00000455405.2	-	0	481																											AGGCAGATCAGGGCCACACGC	0.577000													10	208					0	0	0.00010058	0	0
LOC101929735	101929735	broad.mit.edu	37	14	22935262	22935262	+	RNA	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:22935262G>A	ENST00000514473.2	-	0	225				AE000661.37_ENST00000556777.1_RNA																							GAAAGGCACTGCTTTCTGtta	0.378000													20	132					0	0	0.000175454	0	0
DLX2	1746	broad.mit.edu	37	2	172966256	172966256	+	Silent	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:172966256C>T	ENST00000234198.4	-	2	880	c.519G>A	c.(517-519)aaG>aaA	p.K173K	DLX2_ENST00000466293.2_Silent_p.K173K	NM_004405.3	NP_004396.1	Q07687	DLX2_HUMAN	distal-less homeobox 2	173						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(2)|urinary_tract(1)	11			OV - Ovarian serous cystadenocarcinoma(117;0.216)			AGTATTGAGTCTTTTGGAAAC	0.617000													17	26					0	0	7.07596e-05	0	0
HENMT1	113802	broad.mit.edu	37	1	109191350	109191350	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:109191350G>A	ENST00000370032.5	-	8	1440	c.1020C>T	c.(1018-1020)ttC>ttT	p.F340F	HENMT1_ENST00000370031.1_Silent_p.F371F|HENMT1_ENST00000402983.1_Silent_p.F340F	NM_144584.2	NP_653185.2	Q5T8I9	HENMT_HUMAN	HEN1 methyltransferase homolog 1 (Arabidopsis)	340					gene silencing by RNA|piRNA metabolic process	P granule	metal ion binding|O-methyltransferase activity|RNA binding|RNA methyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|stomach(1)	16						GCAGAGGTACGAAAAATTTAT	0.473000													9	71					0	0	3.86212e-05	0	0
USP29	57663	broad.mit.edu	37	19	57640991	57640991	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:57640991A>C	ENST00000254181.4	+	4	1402	c.948A>C	c.(946-948)caA>caC	p.Q316H	USP29_ENST00000598197.1_Missense_Mutation_p.Q316H	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	316					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TACTCACTCAAGGTGTCCCAT	0.413000													17	47					0	0	0.000132079	0	0
IPO5	3843	broad.mit.edu	37	13	98652899	98652899	+	Splice_Site	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr13:98652899C>T	ENST00000261574.5	+	13	1342	c.1162_splice	c.e13+1	p.P388_splice	IPO5_ENST00000490680.1_Splice_Site_p.P370_splice|IPO5_ENST00000539640.1_Splice_Site_p.P245_splice	NM_002271.4	NP_002262.3	O00410	IPO5_HUMAN	importin 5	370					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			breast(2)|endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	27						GCTTCAAAATCGTAAGCTGTG	0.398000													23	90					0	0	5.49717e-05	0	0
MTHFD1	4522	broad.mit.edu	37	14	64906890	64906890	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:64906890C>T	ENST00000555709.1	+	18	2108	c.1721C>T	c.(1720-1722)gCt>gTt	p.A574V	MTHFD1_ENST00000216605.7_Missense_Mutation_p.A630V|MTHFD1_ENST00000555252.1_Missense_Mutation_p.A554V|CTD-2555O16.2_ENST00000556640.1_RNA|MTHFD1_ENST00000545908.1_Missense_Mutation_p.A630V	NM_005956.3	NP_005947.3	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	574	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	30				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	GCTGTCCTGGCTCTCACCACT	0.493000													38	73					0	0	0.000319135	0	0
ARMC6	93436	broad.mit.edu	37	19	19162882	19162882	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:19162882G>A	ENST00000535612.1	+	5	1163	c.731G>A	c.(730-732)tGg>tAg	p.W244*	ARMC6_ENST00000546344.1_Nonsense_Mutation_p.W151*|ARMC6_ENST00000392335.2_Nonsense_Mutation_p.W219*|ARMC6_ENST00000392336.3_Nonsense_Mutation_p.W244*|ARMC6_ENST00000269932.6_Nonsense_Mutation_p.W219*	NM_001199196.1	NP_001186125.1	Q6NXE6	ARMC6_HUMAN	armadillo repeat containing 6	244							protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|liver(2)|lung(5)|ovary(1)|prostate(1)	14			OV - Ovarian serous cystadenocarcinoma(5;5.66e-06)|Epithelial(12;0.000391)			GAAGCCTGCTGGGCCCTGCGT	0.577000													5	36					0	0	1.23904e-05	0	0
NCAN	1463	broad.mit.edu	37	19	19339082	19339082	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr19:19339082C>T	ENST00000252575.5	+	8	2696	c.2653C>T	c.(2653-2655)Cca>Tca	p.P885S	NCAN_ENST00000538881.1_Missense_Mutation_p.P336S	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	885					axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			GGTTGGAGTTCCAGCCATGTC	0.602000													14	57					0	0	0.000219431	0	0
KIF27	55582	broad.mit.edu	37	9	86451956	86451956	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr9:86451956G>A	ENST00000297814.2	-	18	4309	c.4166C>T	c.(4165-4167)tCc>tTc	p.S1389F	KIF27_ENST00000413982.1_Missense_Mutation_p.S1323F|RP11-575L7.2_ENST00000458016.1_RNA|KIF27_ENST00000334204.2_Missense_Mutation_p.S1292F|RP11-575L7.2_ENST00000439378.3_RNA|RP11-575L7.2_ENST00000417672.1_RNA|RP11-575L7.4_ENST00000591217.1_RNA	NM_017576.1	NP_060046.1	Q86VH2	KIF27_HUMAN	kinesin family member 27	1389					cilium assembly|microtubule-based movement	cilium|cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(7)|lung(17)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	43						TACTTCGATGGAATCAGCAGC	0.363000													25	29					0	0	7.16444e-05	0	0
PLEC	5339	broad.mit.edu	37	8	144995804	144995804	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:144995804G>A	ENST00000322810.4	-	32	8765	c.8596C>T	c.(8596-8598)Ctg>Ttg	p.L2866L	PLEC_ENST00000356346.3_Silent_p.L2715L|PLEC_ENST00000357649.2_Silent_p.L2733L|PLEC_ENST00000398774.2_Silent_p.L2697L|PLEC_ENST00000436759.2_Silent_p.L2756L|PLEC_ENST00000354958.2_Silent_p.L2707L|PLEC_ENST00000345136.3_Silent_p.L2729L|PLEC_ENST00000527096.1_Silent_p.L2752L|PLEC_ENST00000354589.3_Silent_p.L2729L	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	2866	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GCCTCCAGCAGGATGAGGGCC	0.662000													14	38					0	0	0.000308642	0	0
SNTG2	54221	broad.mit.edu	37	2	1079206	1079206	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:1079206G>A	ENST00000308624.5	+	2	204	c.75G>A	c.(73-75)acG>acA	p.T25T	SNTG2_ENST00000407292.1_Silent_p.T25T	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	25					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding	p.T25T(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		CCCTACAGACGAAAACCACTA	0.478000													12	117					0	0	0.000308642	0	0
FLT1	2321	broad.mit.edu	37	13	29041220	29041220	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr13:29041220C>T	ENST00000282397.4	-	3	459	c.208G>A	c.(208-210)Gaa>Aaa	p.E70K	FLT1_ENST00000539099.1_Missense_Mutation_p.E70K|FLT1_ENST00000541932.1_Missense_Mutation_p.E70K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	70	Ig-like C2-type 1.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	CTTTCGCTTTCCTTACTCACC	0.448000													18	42					0	0	0.000175454	0	0
RGS7	6000	broad.mit.edu	37	1	241262011	241262011	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:241262011G>A	ENST00000366565.1	-	3	511	c.130C>T	c.(130-132)Cgt>Tgt	p.R44C	RGS7_ENST00000348120.2_Missense_Mutation_p.R44C|RGS7_ENST00000446183.2_5'UTR|RGS7_ENST00000331110.7_Missense_Mutation_p.R18C|RGS7_ENST00000366563.1_Missense_Mutation_p.R44C|RGS7_ENST00000366564.1_Missense_Mutation_p.R44C|RGS7_ENST00000366562.4_Missense_Mutation_p.R44C|RGS7_ENST00000401882.1_Missense_Mutation_p.R44C|RGS7_ENST00000407727.1_Missense_Mutation_p.R44C	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	44	DEP.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity	p.R44S(2)		breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TTGACCGTACGAATAGGAATT	0.358000													10	49					0	0	6.40141e-05	0	0
PCDH17	27253	broad.mit.edu	37	13	58208094	58208094	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr13:58208094T>C	ENST00000377918.3	+	1	1440	c.1414T>C	c.(1414-1416)Ttc>Ctc	p.F472L		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	472	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCCGCCTCGGTTCACCAAAGG	0.617000													5	29					0	0	1.23904e-05	0	0
SLC6A20	54716	broad.mit.edu	37	3	45817435	45817435	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:45817435C>T	ENST00000358525.4	-	4	515	c.400G>A	c.(400-402)Ggc>Agc	p.G134S	SLC6A20_ENST00000456124.2_Missense_Mutation_p.G134S|SLC6A20_ENST00000353278.4_Missense_Mutation_p.G134S	NM_020208.3	NP_064593.1	Q9NP91	S6A20_HUMAN	solute carrier family 6 (proline IMINO transporter), member 20	134					cellular nitrogen compound metabolic process|glycine transport|proline transport	apical plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(1)|large_intestine(6)|ovary(2)|skin(2)|urinary_tract(1)	13				BRCA - Breast invasive adenocarcinoma(193;0.01)|KIRC - Kidney renal clear cell carcinoma(197;0.0225)|Kidney(197;0.0267)		TCATCGTAGCCCGTGTGGTTA	0.567000													23	72					0	0	0.000184323	0	0
TTF2	8458	broad.mit.edu	37	1	117618345	117618345	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:117618345C>G	ENST00000369466.3	+	5	1183	c.1139C>G	c.(1138-1140)aCg>aGg	p.T380R		NM_003594.3	NP_003585.3	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase II	380					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(24)|ovary(1)|prostate(2)|skin(2)|urinary_tract(2)	50	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		GACTTAGAGACGAAGGAAAAC	0.517000													7	37					0	0	8.12818e-05	0	0
KDR	3791	broad.mit.edu	37	4	55976861	55976861	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:55976861G>A	ENST00000263923.4	-	8	1346	c.1051C>T	c.(1051-1053)Cct>Tct	p.P351S		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	351	Ig-like C2-type 4.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	TACTTCGCAGGGATTCTGACA	0.413000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			10	29					0	0	6.40141e-05	0	0
PPP1R16B	26051	broad.mit.edu	37	20	37547165	37547165	+	Silent	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr20:37547165G>A	ENST00000299824.1	+	11	1749	c.1560G>A	c.(1558-1560)ttG>ttA	p.L520L	PPP1R16B_ENST00000373331.2_Silent_p.L478L	NM_015568.2	NP_056383.1	Q96T49	PP16B_HUMAN	protein phosphatase 1, regulatory subunit 16B	520					regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			biliary_tract(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(23)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	49		Myeloproliferative disorder(115;0.00878)				AGGCCCCCTTGATCGGAGGCA	0.597000													13	41					0	0	0.000219431	0	0
GRIA2	2891	broad.mit.edu	37	4	158242727	158242727	+	Silent	SNP	T	T	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:158242727T>A	ENST00000296526.7	+	6	1183	c.858T>A	c.(856-858)ccT>ccA	p.P286P	GRIA2_ENST00000507898.1_Silent_p.P239P|GRIA2_ENST00000264426.9_Silent_p.P286P|GRIA2_ENST00000449365.1_Silent_p.P239P|GRIA2_ENST00000393815.2_Silent_p.P239P	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	286					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	AAGAATACCCTGGAGCTCACA	0.378000													18	36					0	0	9.7654e-05	0	0
NLGN3	54413	broad.mit.edu	37	X	70389544	70389544	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:70389544G>A	ENST00000374051.3	+	7	2406	c.2084G>A	c.(2083-2085)gGg>gAg	p.G695E	NLGN3_ENST00000536169.1_Missense_Mutation_p.G675E|NLGN3_ENST00000476589.1_3'UTR|NLGN3_ENST00000358741.3_Missense_Mutation_p.G715E	NM_018977.3	NP_061850.2	Q9NZ94	NLGN3_HUMAN	neuroligin 3	715					neuron cell-cell adhesion|positive regulation of synaptogenesis|receptor-mediated endocytosis|social behavior|synapse assembly	cell surface|endocytic vesicle|integral to plasma membrane|synapse	neurexin binding|receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	37	Renal(35;0.156)					ATCGCCGTGGGGGCCTCCCTC	0.627000													7	33					0	0	0.000274275	0	0
AMFR	267	broad.mit.edu	37	16	56436943	56436943	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr16:56436943G>A	ENST00000290649.5	-	7	1138	c.928C>T	c.(928-930)Cgt>Tgt	p.R310C		NM_001144.5	NP_001135.3	Q9UKV5	AMFR2_HUMAN	autocrine motility factor receptor, E3 ubiquitin protein ligase	310					endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|protein oligomerization|protein polyubiquitination	integral to endoplasmic reticulum membrane|integral to membrane of membrane fraction	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding	p.R310C(1)		NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17						TTGTGCCGACGAATTCGACGT	0.428000													41	67					0	0	8.96297e-05	0	0
C2orf16	84226	broad.mit.edu	37	2	27804235	27804235	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:27804235C>T	ENST00000408964.2	+	1	4847	c.4796C>T	c.(4795-4797)tCc>tTc	p.S1599F		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	1599	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.									breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					AAAAACCATTCCAGTCCTTCT	0.552000													8	64					0	0	2.17888e-05	0	0
DCAF4	26094	broad.mit.edu	37	14	73404717	73404717	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:73404717C>T	ENST00000555042.1	+	2	96	c.31C>T	c.(31-33)Cga>Tga	p.R11*	DCAF4_ENST00000510612.1_3'UTR|DCAF4_ENST00000553457.1_5'UTR|DCAF4_ENST00000509153.1_Nonsense_Mutation_p.R11*|DCAF4_ENST00000394234.2_Intron|DCAF4_ENST00000358377.2_Nonsense_Mutation_p.R11*|DCAF4_ENST00000353777.3_Nonsense_Mutation_p.R11*	NM_001163508.1	NP_001156980.1	Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4	11						CUL4 RING ubiquitin ligase complex				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|skin(1)	22						GAGTAGAAGACGACATGGGAG	0.473000													57	120					0	0	0.000147903	0	0
KRT84	3890	broad.mit.edu	37	12	52775207	52775207	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr12:52775207C>T	ENST00000257951.3	-	5	1081	c.1015G>A	c.(1015-1017)Gcc>Acc	p.A339T	RP3-416H24.4_ENST00000547174.1_RNA	NM_033045.3	NP_149034.2	Q9NSB2	KRT84_HUMAN	keratin 84	339	Coil 2.|Rod.					keratin filament	structural constituent of epidermis			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(10)|skin(3)	27	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCATACTGGGCCTTGACCTCA	0.587000													31	156					0	0	0.000339439	0	0
FGD3	89846	broad.mit.edu	37	9	95797848	95797848	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr9:95797848C>T	ENST00000375482.3	+	18	2651	c.2155C>T	c.(2155-2157)Cct>Tct	p.P719S	FGD3_ENST00000337352.6_Missense_Mutation_p.P719S|FGD3_ENST00000416701.2_Missense_Mutation_p.P718S|FGD3_ENST00000538555.1_Missense_Mutation_p.P322S	NM_001083536.1	NP_001077005.1	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	719					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	17						GCTTCAGGTCCCTATGGGCGC	0.657000													13	22					0	0	7.07596e-05	0	0
C1GALT1C1	29071	broad.mit.edu	37	X	119760874	119760874	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chrX:119760874C>T	ENST00000304661.5	-	2	386	c.148G>A	c.(148-150)Gaa>Aaa	p.E50K	C1GALT1C1_ENST00000371313.2_Missense_Mutation_p.E50K	NM_001011551.2	NP_001011551.1	Q96EU7	C1GLC_HUMAN	C1GALT1-specific chaperone 1	50						integral to membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	11						AAGATATCTTCTTTGTTAGGA	0.398000													26	160					0	0	0.000117367	0	0
TNXB	7148	broad.mit.edu	37	6	32046849	32046849	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr6:32046849C>T	ENST00000375244.3	-	11	4537	c.4336G>A	c.(4336-4338)Ggg>Agg	p.G1446R	TNXB_ENST00000375247.2_Missense_Mutation_p.G1446R			P22105	TENX_HUMAN	tenascin XB	1533					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						ACGCGCTGCCCCTCGTGGAGG	0.692000													16	99					0	0	5.01169e-05	0	0
SRSF4	6429	broad.mit.edu	37	1	29475298	29475309	+	In_Frame_Del	DEL	CTGCGACTGCGA	CTGCGACTGCGA	-	rs146585589	byFrequency	TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:29475298_29475309delCTGCGACTGCGA	ENST00000373795.4	-	6	1332_1343	c.1098_1109delTCGCAGTCGCAG	c.(1096-1110)agc>ag	p.SRSRS366del	SRSF4_ENST00000546138.1_3'UTR|SRSF4_ENST00000466448.1_5'UTR	NM_005626.4	NP_005617.2	Q08170	SRSF4_HUMAN	serine/arginine-rich splicing factor 4	366	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(1)	27						cttgctgcggctgcgactgcgactgcggctct	0.618													8	22	---	---	---	---					
APOA1BP	128240	broad.mit.edu	37	1	156562376	156562376	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr1:156562376delA	ENST00000368235.3	+	4	473	c.430delA	c.(430-432)aafs	p.K144fs	APOA1BP_ENST00000368234.3_Frame_Shift_Del_p.K144fs|APOA1BP_ENST00000467374.1_3'UTR|APOA1BP_ENST00000368233.3_Frame_Shift_Del_p.K144fs	NM_144772.2	NP_658985.2	Q8NCW5	AIBP_HUMAN	apolipoprotein A-I binding protein	144	YjeF N-terminal.					extracellular region	protein binding			central_nervous_system(1)|large_intestine(2)|lung(3)|prostate(2)|urinary_tract(1)	9	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTATTACCCCAAAAGGCCTAA	0.567													7	368	---	---	---	---					
NCOA1	8648	broad.mit.edu	37	2	24985616	24985618	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr2:24985616_24985618delCTT	ENST00000405141.1	+	23	4837_4839	c.4126_4128delCTT	c.(4126-4128)del	p.L1377del	NCOA1_ENST00000407230.1_In_Frame_Del_p.L1226del|NCOA1_ENST00000406961.1_In_Frame_Del_p.L1377del|NCOA1_ENST00000395856.3_In_Frame_Del_p.L1377del|NCOA1_ENST00000538539.1_In_Frame_Del_p.L1377del|NCOA1_ENST00000348332.3_In_Frame_Del_p.L1377del|NCOA1_ENST00000288599.5_In_Frame_Del_p.L1377del			Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1	1377									PAX3/NCOA1(8)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(26)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	53	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATCCACTGACCTTCTCAAAACAG	0.424			T	PAX3	alveolar rhadomyosarcoma								91	268	---	---	---	---					
ZXDC	79364	broad.mit.edu	37	3	126178522	126178522	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr3:126178522delT	ENST00000389709.3	-	7	2239	c.2186delA	c.(2185-2187)agfs	p.K729fs		NM_025112.4	NP_079388.3	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C	729					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(9)|ovary(1)	17				GBM - Glioblastoma multiforme(114;0.155)		TCCTCTCTGCTTTTTTTCCTT	0.522													7	785	---	---	---	---					
ARHGAP10	79658	broad.mit.edu	37	4	148827861	148827861	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr4:148827861delA	ENST00000336498.3	+	11	1346	c.1107delA	c.(1105-1107)ggfs	p.G369fs	ARHGAP10_ENST00000414545.2_Frame_Shift_Del_p.G18fs	NM_024605.3	NP_078881.3	A1A4S6	RHG10_HUMAN	Rho GTPase activating protein 10	369	PH.				apoptosis|filopodium assembly|regulation of apoptosis|small GTPase mediated signal transduction	cytosol|perinuclear region of cytoplasm|plasma membrane	cytoskeletal adaptor activity|SH3 domain binding			autonomic_ganglia(2)|endometrium(5)|kidney(2)|large_intestine(4)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33	all_hematologic(180;0.151)	Renal(17;0.0166)		GBM - Glioblastoma multiforme(119;0.0423)		CTCTGGGTGGAAAGGAAGCTG	0.393													13	65	---	---	---	---					
C8orf86	389649	broad.mit.edu	37	8	38385986	38385987	+	Frame_Shift_Ins	INS	-	-	CC			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr8:38385986_38385987insCC	ENST00000358138.1	-	1	193_194	c.169_170insGG	c.(169-171)tgafs	p.*57fs	C8orf86_ENST00000437935.2_Frame_Shift_Ins_p.*57fs	NM_207412.1	NP_997295.1	Q6ZUL3	CH086_HUMAN	chromosome 8 open reading frame 86	57										breast(1)|endometrium(1)|large_intestine(1)|lung(1)|prostate(1)	5						TCGCTGCTCAACCCTTTCCTTC	0.550													15	46	---	---	---	---					
TEP1	7011	broad.mit.edu	37	14	20852647	20852647	+	Frame_Shift_Del	DEL	C	C	-			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:20852647delC	ENST00000262715.5	-	23	3282	c.3242delG	c.(3241-3243)gtfs	p.G1081fs	TEP1_ENST00000556935.1_Frame_Shift_Del_p.G973fs	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1081					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding	p.V1082fs*47(1)		NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGCTGCCACACCCCCCCACTC	0.587													7	401	---	---	---	---					
CTAGE5	4253	broad.mit.edu	37	14	39746242	39746243	+	Frame_Shift_Ins	INS	-	-	T	rs75842899	byFrequency	TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr14:39746242_39746243insT	ENST00000553728.1	+	6	1986_1987	c.1773_1774insT	c.(1771-1776)ctttttfs	p.LF591fs	CTAGE5_ENST00000396165.4_Frame_Shift_Ins_p.LF27fs|CTAGE5_ENST00000280083.3_Frame_Shift_Ins_p.LF56fs|CTAGE5_ENST00000556148.1_Intron|CTAGE5_ENST00000553352.1_Frame_Shift_Ins_p.LF27fs|CTAGE5_ENST00000341502.5_Frame_Shift_Ins_p.LF56fs|CTAGE5_ENST00000396158.2_Frame_Shift_Ins_p.LF56fs|CTAGE5_ENST00000557038.1_5'UTR|RP11-407N17.3_ENST00000603904.1_Frame_Shift_Ins_p.LF27fs|CTAGE5_ENST00000341749.3_Frame_Shift_Ins_p.LF44fs|CTAGE5_ENST00000348007.3_Frame_Shift_Ins_p.LF56fs																							TTGCTGTTCTCTTTTTTTTGTG	0.371													8	144	---	---	---	---					
MESP2	145873	broad.mit.edu	37	15	90320121	90320144	+	In_Frame_Del	DEL	AGGGGCAGGGGCAAGGGCAGGGGC	AGGGGCAGGGGCAAGGGCAGGGGC	-	rs56192595		TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr15:90320121_90320144delAGGGGCAGGGGCAAGGGCAGGGGC	ENST00000341735.3	+	1	533_556	c.533_556delAGGGGCAGGGGCAAGGGCAGGGGC	c.(532-558)gag>g	p.EGQGQGQGQ178del	MESP2_ENST00000558723.1_Intron|MESP2_ENST00000560219.1_Intron	NM_001039958.1	NP_001035047.1	Q0VG99	MESP2_HUMAN	mesoderm posterior 2 homolog (mouse)	178					Notch signaling pathway	nucleus	DNA binding	p.Q198_G205delQGQGQGQG(1)		kidney(1)|large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)			ACGCaggcggaggggcaggggcaagggcaggggcaggggcaggg	0.777													2	4	---	---	---	---					
COIL	8161	broad.mit.edu	37	17	55028117	55028118	+	Frame_Shift_Ins	INS	-	-	T			TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr17:55028117_55028118insT	ENST00000240316.4	-	2	519_520	c.485_486insA	c.(484-486)aaafs	p.K162fs		NM_004645.2	NP_004636.1	P38432	COIL_HUMAN	coilin	162						Cajal body|nucleolus	protein C-terminus binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	15	Breast(9;6.15e-08)					TTTTTCTCTTGTTTTTTTTGCT	0.366													15	270	---	---	---	---					
SMDT1	91689	broad.mit.edu	37	22	42478046	42478048	+	In_Frame_Del	DEL	GAT	GAT	-	rs141840500		TCGA-D3-A2JL-06A-11D-A196-08	TCGA-D3-A2JL-10A-01D-A198-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	06d6341f-cb6d-4a7e-9213-c7bb394aca56	bf91785e-7b33-4bd0-8ff5-c20c20b4e985	g.chr22:42478046_42478048delGAT	ENST00000331479.3	+	2	378_380	c.304_306delGAT	c.(304-306)del	p.D107del	SMDT1_ENST00000547929.1_Intron	NM_033318.4	NP_201575.3			single-pass membrane protein with aspartate-rich tail 1																		TGTTCCAGAGGATGATGATGATG	0.478													7	253	---	---	---	---					
