Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SNIP1	79753	broad.mit.edu	37	1	38003598	38003598	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:38003598G>A	ENST00000296215.6	-	4	1014	c.942C>T	c.(940-942)acC>acT	p.T314T		NM_024700.3	NP_078976.2	Q8TAD8	SNIP1_HUMAN	Smad nuclear interacting protein 1	314	FHA.				production of miRNAs involved in gene silencing by miRNA	nucleus	protein binding			breast(2)|cervix(2)|endometrium(1)|large_intestine(3)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	25		Myeloproliferative disorder(586;0.0393)				CATCAGCACGGGTATATTCCA	0.458000													14	21					0	0	1	0	0
CA2	760	broad.mit.edu	37	8	86393018	86393018	+	Silent	SNP	A	A	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:86393018A>G	ENST00000285379.5	+	7	1013	c.783A>G	c.(781-783)taA>taG	p.*261*		NM_000067.2	NP_000058.1	P00918	CAH2_HUMAN	carbonic anhydrase II	0					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(2)|cervix(1)|large_intestine(2)|lung(5)|prostate(1)	11					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	CCTTCAAATAAGATGGTCCCA	0.463000													10	23					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94645372	94645372	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:94645372T>C	ENST00000260526.6	-	20	2571	c.2389A>G	c.(2389-2391)Aac>Gac	p.N797D	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	797	Rho-GAP.				Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		AGAATTCGGTTTATTTCTATA	0.313000													22	49					0	0	1	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117432652	117432652	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:117432652C>T	ENST00000160373.3	-	4	689	c.598G>A	c.(598-600)Gaa>Aaa	p.E200K	CTTNBP2_ENST00000487820.1_5'UTR	NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	200										breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		TTTTCCTCTTCCAGTTTGGCC	0.468000													19	38					0	0	1	0	0
UBE4A	9354	broad.mit.edu	37	11	118257192	118257192	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:118257192C>T	ENST00000252108.3	+	16	2583	c.2452C>T	c.(2452-2454)Cga>Tga	p.R818*	UBE4A_ENST00000545354.1_Nonsense_Mutation_p.R290*|UBE4A_ENST00000431736.2_Nonsense_Mutation_p.R825*	NM_001204077.1|NM_004788.3	NP_001191006.1|NP_004779.2	Q14139	UBE4A_HUMAN	ubiquitination factor E4A	818					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(7)|liver(2)|lung(14)|ovary(3)|prostate(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	56	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		TGAGAAGGATCGAGGTGAATG	0.463000													23	39					0	0	1	0	0
TTI2	80185	broad.mit.edu	37	8	33367357	33367357	+	Silent	SNP	C	C	T	rs143175380		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:33367357C>T	ENST00000431156.2	-	3	1359	c.741G>A	c.(739-741)agG>agA	p.R247R	TTI2_ENST00000520636.1_Silent_p.R247R|TTI2_ENST00000360742.5_Silent_p.R247R	NM_001102401.2	NP_001095871.1	Q6NXR4	CH041_HUMAN	TELO2 interacting protein 2	247							binding										CGGGAAGTACCCTTTCCAGAT	0.473000													15	19					0	0	1	0	0
TRBV10-1	28585	broad.mit.edu	37	7	142231586	142231586	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:142231586C>T	ENST00000390364.3	-	0	398																											TCACTGCTGGCGCAGAAATAT	0.537000													36	54					0	0	1	0	0
IL17RD	54756	broad.mit.edu	37	3	57135231	57135231	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:57135231G>A	ENST00000296318.7	-	11	1228	c.1140C>T	c.(1138-1140)ttC>ttT	p.F380F	IL17RD_ENST00000463523.1_Silent_p.F236F|IL17RD_ENST00000427856.2_Silent_p.F356F|IL17RD_ENST00000320057.5_Silent_p.F236F	NM_017563.3	NP_060033.3	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D	380	SEFIR.					Golgi membrane|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)	16				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		AGTCCTGGAGGAAGTAGGCGA	0.557000													7	12					0	0	1	0	0
RCC1	1104	broad.mit.edu	37	1	28864371	28864371	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:28864371C>T	ENST00000373833.6	+	13	1403	c.1118C>T	c.(1117-1119)aCc>aTc	p.T373I	RCC1_ENST00000398958.2_Missense_Mutation_p.T373I|RCC1_ENST00000373831.3_Missense_Mutation_p.T404I|RCC1_ENST00000373832.1_Missense_Mutation_p.T373I			P18754	RCC1_HUMAN	regulator of chromosome condensation 1	373					cell division|chromosome segregation|G1/S transition of mitotic cell cycle|mitosis|mitotic spindle organization|regulation of mitosis|regulation of S phase of mitotic cell cycle|spindle assembly|viral reproduction	condensed nuclear chromosome|cytoplasm|nuclear chromatin|nuclear membrane|nucleoplasm	histone binding|nucleosomal DNA binding|Ran guanyl-nucleotide exchange factor activity			breast(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;0.000318)|all_lung(284;0.000434)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.00989)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|KIRC - Kidney renal clear cell carcinoma(1967;0.0101)|BRCA - Breast invasive adenocarcinoma(304;0.022)|READ - Rectum adenocarcinoma(331;0.0649)		GGCATGGGCACCAACTACCAG	0.582000													4	6					0	0	1	0	0
OR4N2	390429	broad.mit.edu	37	14	20295638	20295638	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:20295638G>A	ENST00000315947.1	+	1	31	c.31G>A	c.(31-33)Gaa>Aaa	p.E11K	OR4N2_ENST00000568211.1_Missense_Mutation_p.E11K	NM_001004723.1	NP_001004723.1	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	11					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AGTGATAAGAGAATTCATCCT	0.388000													34	137					0	0	1	0	0
POMGNT2	84892	broad.mit.edu	37	3	43121553	43121553	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:43121553G>A	ENST00000344697.2	-	2	1716	c.1371C>T	c.(1369-1371)ctC>ctT	p.L457L	GTDC2_ENST00000441964.1_Silent_p.L457L	NM_032806.4	NP_116195.2																					TGGTTTGAATGAGGGACGGGA	0.617000													15	26					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38704973	38704973	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:38704973G>A	ENST00000359357.3	+	4	496	c.242G>A	c.(241-243)gGa>gAa	p.G81E	DNAH8_ENST00000449981.2_Missense_Mutation_p.G298E|DNAH8_ENST00000441566.1_Missense_Mutation_p.G81E					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TCCAAGCAGGGAGAATCTGAA	0.323000													25	37					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274150	39274150	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:39274150T>A	ENST00000391413.2	-	1	456	c.418A>T	c.(418-420)Agc>Tgc	p.S140C		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	140	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.S140C(2)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ctggagatgctgcagctgggg	0.672000													4	42					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41038976	41038976	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:41038976C>T	ENST00000399564.4	-	21	2526	c.2076G>A	c.(2074-2076)ggG>ggA	p.G692G	MROH2B_ENST00000506092.2_Silent_p.G247G	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		GGCTCTTTTTCCCAGAAAAAA	0.438000													9	20					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25479235	25479235	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:25479235G>A	ENST00000453082.2	+	0	1776					NR_003343.1																						CTCGTGTTGGGCCCACAGGCC	0.587000													10	11					0	0	1	0	0
OR7G2	390882	broad.mit.edu	37	19	9213386	9213386	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:9213386G>A	ENST00000305456.2	-	1	596	c.597C>T	c.(595-597)ttC>ttT	p.F199F		NM_001005193.1	NP_001005193.1	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G, member 2	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|skin(3)	16						CCAGTTCACAGAAGAAGAGCG	0.468000													18	19					0	0	1	0	0
ONECUT2	9480	broad.mit.edu	37	18	55103586	55103586	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:55103586C>T	ENST00000491143.2	+	1	670	c.638C>T	c.(637-639)cCc>cTc	p.P213L		NM_004852.2	NP_004843.2	O95948	ONEC2_HUMAN	one cut homeobox 2	213					organ morphogenesis	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(4)|ovary(2)|skin(1)	15		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		CTCTACAGTCCCTACAAGGAG	0.687000													7	12					0	0	1	0	0
OR2A12	346525	broad.mit.edu	37	7	143792622	143792622	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:143792622C>T	ENST00000408949.2	+	1	482	c.422C>T	c.(421-423)aCt>aTt	p.T141I		NM_001004135.1	NP_001004135.1	Q8NGT7	O2A12_HUMAN	olfactory receptor, family 2, subfamily A, member 12	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)	25	Melanoma(164;0.0783)					AGAGTGTGCACTGTCCTGGCC	0.448000													20	56					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24817561	24817561	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:24817561A>G	ENST00000395799.3	+	16	4415	c.4286A>G	c.(4285-4287)cAg>cGg	p.Q1429R	CTD-2515A14.1_ENST00000568895.1_RNA|TNRC6A_ENST00000315183.7_Missense_Mutation_p.Q1380R	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1429					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		GCGCAGAGTCAGAGAAGCGTG	0.502000													13	19					0	0	1	0	0
ERI1	90459	broad.mit.edu	37	8	8887319	8887319	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:8887319C>T	ENST00000523898.1	+	8	1504	c.825C>T	c.(823-825)acC>acT	p.T275T	ERI1_ENST00000520332.1_Intron|ERI1_ENST00000519292.1_Silent_p.T275T|ERI1_ENST00000250263.7_Silent_p.T275T			Q8IV48	ERI1_HUMAN	exoribonuclease 1	275	Exonuclease.				gene silencing by RNA|rRNA 3'-end processing	cytoplasm|histone pre-mRNA 3'end processing complex|nucleolus	3'-5' exonuclease activity|histone pre-mRNA stem-loop binding|metal ion binding|ribosome binding|rRNA binding			NS(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)	11					Adenosine monophosphate(DB00131)	GAAGCCAAACCAAACTGACAA	0.358000													16	32					0	0	1	0	0
SMR3A	26952	broad.mit.edu	37	4	71232663	71232663	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:71232663C>T	ENST00000226460.4	+	3	453	c.357C>T	c.(355-357)ttC>ttT	p.F119F		NM_012390.3	NP_036522.3	Q99954	SMR3A_HUMAN	submaxillary gland androgen regulated protein 3A	119	Pro-rich.					extracellular region				endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(4)	15		all_hematologic(202;0.196)				CTCCATTTTTCCCTGTAAATT	0.512000													20	27					0	0	1	0	0
CTTNBP2NL	55917	broad.mit.edu	37	1	112999513	112999513	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:112999513C>T	ENST00000271277.6	+	6	1624	c.1399C>T	c.(1399-1401)Cag>Tag	p.Q467*	RP4-671G15.3_ENST00000508462.1_RNA|CTTNBP2NL_ENST00000607039.1_3'UTR	NM_018704.2	NP_061174.1	Q9P2B4	CT2NL_HUMAN	CTTNBP2 N-terminal like	467						actin cytoskeleton	protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	29		all_cancers(81;0.00064)|all_epithelial(167;0.000415)|all_lung(203;0.00045)|Lung NSC(69;0.000705)		Lung(183;0.0234)|all cancers(265;0.0246)|Epithelial(280;0.0342)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCACAAATTTCAGTCCCAAGC	0.542000													47	62					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	32364152	32364152	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:32364152C>T	ENST00000357033.4	-	39	5700	c.5494G>A	c.(5494-5496)Gac>Aac	p.D1832N	DMD_ENST00000378677.2_Missense_Mutation_p.D1828N	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	1832	Interaction with SYNM (By similarity).				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TGTAAGTTGTCTCCTCTTTGC	0.338000													19	21					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74004105	74004105	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:74004105G>A	ENST00000301607.3	-	22	5434	c.5181C>T	c.(5179-5181)acC>acT	p.T1727T	EVPL_ENST00000586740.1_Silent_p.T1749T	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1727	Globular 2.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GCCCCGAGGTGGTGACCTCCT	0.642000													33	32					0	0	1	0	0
MCM4	4173	broad.mit.edu	37	8	48883263	48883263	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:48883263C>T	ENST00000262105.2	+	11	1836	c.1627C>T	c.(1627-1629)Ctc>Ttc	p.L543F	MCM4_ENST00000523944.1_Missense_Mutation_p.L543F|MCM4_ENST00000518680.1_3'UTR	NM_005914.3	NP_005905.2	P33991	MCM4_HUMAN	minichromosome maintenance complex component 4	543	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|DNA binding|helicase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(7)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(2)	44		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00327)|all_lung(136;0.00354)				TGCAGTTGGCCTCACTGCGTA	0.577000													16	19					0	0	1	0	0
CHDC2	286464	broad.mit.edu	37	X	36083860	36083860	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:36083860G>A	ENST00000378660.1	+	2	231	c.43_splice	c.e2+1	p.D15_splice	CHDC2_ENST00000313548.4_Splice_Site_p.D15_splice					calponin homology domain containing 2									p.D15Y(1)									TTTAAAGAATGGTAAGCTATG	0.308000													4	11					0	0	1	0	0
TMEM27	57393	broad.mit.edu	37	X	15663086	15663086	+	Silent	SNP	A	A	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:15663086A>C	ENST00000380342.3	-	4	525	c.270T>G	c.(268-270)ccT>ccG	p.P90P		NM_020665.4	NP_065716.1	Q9HBJ8	TMM27_HUMAN	transmembrane protein 27	90					proteolysis	integral to membrane	metallopeptidase activity|peptidyl-dipeptidase activity			endometrium(3)|lung(4)|ovary(1)	8	Hepatocellular(33;0.183)					GATTTTTTGAAGGGTCTGTAA	0.398000													19	23					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183651421	183651421	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:183651421C>T	ENST00000511685.1	+	15	2777	c.2654C>T	c.(2653-2655)tCg>tTg	p.S885L	TENM3_ENST00000502950.1_3'UTR|TENM3_ENST00000406950.2_Missense_Mutation_p.S885L					teneurin transmembrane protein 3																		GTAAATGTCTCGTTTTTCCAT	0.408000													16	40					0	0	1	0	0
IL17RD	54756	broad.mit.edu	37	3	57135230	57135230	+	Missense_Mutation	SNP	G	G	A	rs145766256		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:57135230G>A	ENST00000296318.7	-	11	1229	c.1141C>T	c.(1141-1143)Ctc>Ttc	p.L381F	IL17RD_ENST00000463523.1_Missense_Mutation_p.L237F|IL17RD_ENST00000427856.2_Missense_Mutation_p.L357F|IL17RD_ENST00000320057.5_Missense_Mutation_p.L237F	NM_017563.3	NP_060033.3	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D	381	SEFIR.					Golgi membrane|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)	16				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		AAGTCCTGGAGGAAGTAGGCG	0.557000													7	12					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77375696	77375696	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:77375696C>T	ENST00000282849.5	-	11	2033	c.1614_splice	c.e11-1	p.D539_splice		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	539	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TTGCAAATATCCTGAAATAAA	0.383000													3	6					0	0	1	0	0
SELO	83642	broad.mit.edu	37	22	50649166	50649166	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:50649166C>T	ENST00000380903.2	+	5	1235	c.1177C>T	c.(1177-1179)Ctg>Ttg	p.L393L	RP3-402G11.5_ENST00000492092.1_3'UTR	NM_031454.1	NP_113642.1																					GGCCGAGGCCCTGCAGCCGGA	0.657000											OREG0026676	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	70	39					0	0	1	0	0
CXCL6	6372	broad.mit.edu	37	4	74702957	74702957	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:74702957C>T	ENST00000226317.5	+	3	534	c.280C>T	c.(280-282)Ccg>Tcg	p.P94S	CXCL6_ENST00000503446.1_3'UTR|CXCL6_ENST00000515050.1_Missense_Mutation_p.P94S	NM_002993.3	NP_002984.1	P80162	CXCL6_HUMAN	chemokine (C-X-C motif) ligand 6	94					cell-cell signaling|chemotaxis|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity|heparin binding			large_intestine(1)|lung(7)	8	Breast(15;0.00102)		all cancers(17;0.00176)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			TTGTCTGGACCCGGAAGCCCC	0.443000													14	36					0	0	1	0	0
PCDHGA1	56114	broad.mit.edu	37	5	140712649	140712649	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140712649G>A	ENST00000517417.1	+	1	2398	c.2398G>A	c.(2398-2400)Gac>Aac	p.D800N	PCDHGA1_ENST00000378105.3_Missense_Mutation_p.D800N	NM_018912.2	NP_061735.1														breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|lung(32)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTTACTTGAAGACAAAAAGGA	0.413000													26	29					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75072544	75072544	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:75072544C>T	ENST00000326665.5	-	10	1448	c.1230G>A	c.(1228-1230)ccG>ccA	p.P410P	RP4-612J11.1_ENST00000416017.1_RNA|C1orf173_ENST00000420661.2_Silent_p.P213P	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	410								p.P410P(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						TCCTAGATTTCGGCAAAGACG	0.413000													38	49					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52534765	52534765	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:52534765C>T	ENST00000216286.5	-	2	344	c.345G>A	c.(343-345)acG>acA	p.T115T	NID2_ENST00000541773.1_Silent_p.T62T	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	115	NIDO.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					TGCCGTGGCTCGTGTCGATGT	0.652000													12	23					0	0	1	0	0
IPO11	51194	broad.mit.edu	37	5	61811239	61811239	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:61811239G>A	ENST00000325324.6	+	20	1976	c.1807G>A	c.(1807-1809)Gta>Ata	p.V603I	IPO11_ENST00000409296.3_Missense_Mutation_p.V643I|KIF2A_ENST00000509663.2_3'UTR	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11	603						cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		GGGATGTTTGGTACAATATTT	0.338000													20	35					0	0	1	0	0
CXorf56	63932	broad.mit.edu	37	X	118676541	118676541	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:118676541C>T	ENST00000320339.4	-	5	564	c.293G>A	c.(292-294)cGg>cAg	p.R98Q	CXorf56_ENST00000476164.1_Missense_Mutation_p.R147Q|CXorf56_ENST00000469448.1_5'UTR|CXorf56_ENST00000371594.4_Missense_Mutation_p.R147Q|CXorf56_ENST00000536133.1_Missense_Mutation_p.R133Q|CXorf56_ENST00000486230.1_Missense_Mutation_p.R147Q	NM_001170569.1	NP_001164040.1	Q9H5V9	CX056_HUMAN	chromosome X open reading frame 56	147							protein binding			cervix(1)|endometrium(2)|lung(7)	10						GTCTTTGGTCCGTTTGGTCAT	0.507000													15	38					0	0	1	0	0
CKMT1B	1159	broad.mit.edu	37	15	43890396	43890396	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:43890396G>A	ENST00000300283.6	+	8	1274	c.882G>A	c.(880-882)gaG>gaA	p.E294E	CKMT1B_ENST00000441322.1_Silent_p.E294E	NM_020990.3	NP_066270.1	P12532	KCRU_HUMAN	creatine kinase, mitochondrial 1B	294	Phosphagen kinase C-terminal.				creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity			large_intestine(1)|lung(3)|skin(1)	5		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)	CTCAGGTGGAGAGACTTATCC	0.473000													52	73					0	0	1	0	0
NFRKB	4798	broad.mit.edu	37	11	129742840	129742840	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:129742840G>A	ENST00000446488.3	-	22	2805	c.2702C>T	c.(2701-2703)gCt>gTt	p.A901V	NFRKB_ENST00000304521.5_Missense_Mutation_p.A901V|NFRKB_ENST00000524746.1_Missense_Mutation_p.A901V|NFRKB_ENST00000524794.1_Missense_Mutation_p.A926V	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	901					DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		GGCACTGGGAGCAGAGGTCCC	0.592000													20	29					0	0	1	0	0
CAMK2B	816	broad.mit.edu	37	7	44259765	44259765	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:44259765G>A	ENST00000395749.2	-	23	1973	c.1897C>T	c.(1897-1899)Cgc>Tgc	p.R633C	CAMK2B_ENST00000347193.4_Missense_Mutation_p.R459C|CAMK2B_ENST00000489429.1_5'UTR|CAMK2B_ENST00000350811.3_Missense_Mutation_p.R509C|CAMK2B_ENST00000502837.2_3'UTR|CAMK2B_ENST00000395747.2_Missense_Mutation_p.R485C|CAMK2B_ENST00000358707.3_Missense_Mutation_p.R470C|CAMK2B_ENST00000440254.2_Missense_Mutation_p.R509C|CAMK2B_ENST00000258682.6_Missense_Mutation_p.R484C|CAMK2B_ENST00000346990.4_Missense_Mutation_p.R416C|CAMK2B_ENST00000457475.1_Missense_Mutation_p.R485C|CAMK2B_ENST00000353625.4_Missense_Mutation_p.R446C	NM_001220.4	NP_001211.3	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II beta	633					interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)	18						TGGCTGGTGCGGGGCCGGCCC	0.672000													4	7					0	0	1	0	0
PLCD3	113026	broad.mit.edu	37	17	43198601	43198601	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:43198601G>A	ENST00000322765.5	-	2	415	c.302C>T	c.(301-303)cCg>cTg	p.P101L	PLCD3_ENST00000540511.1_5'UTR	NM_133373.3	NP_588614.1	Q8N3E9	PLCD3_HUMAN	phospholipase C, delta 3	101	PH.|Substrate binding (By similarity).				intracellular signal transduction|lipid catabolic process	cleavage furrow|cytoplasm|membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(2)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)|stomach(2)|urinary_tract(2)	17					Phosphatidylserine(DB00144)	TGGCGCACGCGGGATGCGCCG	0.731000													10	10					0	0	1	0	0
OR10T2	128360	broad.mit.edu	37	1	158369155	158369155	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:158369155G>A	ENST00000334438.1	-	1	101	c.102C>T	c.(100-102)ctC>ctT	p.L34L		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					TCAAGTATAGGAGAAGAAAGA	0.488000													12	9					0	0	1	0	0
ERN1	2081	broad.mit.edu	37	17	62130278	62130278	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:62130278G>A	ENST00000433197.2	-	17	2210	c.2115C>T	c.(2113-2115)atC>atT	p.I705I		NM_001433.3	NP_001424.3	O75460	ERN1_HUMAN	endoplasmic reticulum to nucleus signaling 1	705	Protein kinase.				activation of signaling protein activity involved in unfolded protein response|apoptosis|cell cycle arrest|induction of apoptosis|mRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to endoplasmic reticulum membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(4)|kidney(1)|lung(2)|ovary(1)|stomach(1)	9						TCATGGCCTTGATCTTGCCGT	0.532000													12	6					0	0	1	0	0
SELO	83642	broad.mit.edu	37	22	50649165	50649165	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:50649165C>T	ENST00000380903.2	+	5	1234	c.1176C>T	c.(1174-1176)gcC>gcT	p.A392A	RP3-402G11.5_ENST00000492092.1_3'UTR	NM_031454.1	NP_113642.1																					TGGCCGAGGCCCTGCAGCCGG	0.657000											OREG0026676	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	70	38					0	0	1	0	0
SLC6A14	11254	broad.mit.edu	37	X	115582806	115582806	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:115582806G>A	ENST00000371900.4	+	8	1218	c.1130G>A	c.(1129-1131)gGa>gAa	p.G377E		NM_007231.3	NP_009162.1	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid transporter), member 14	377					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	CATATATCTGGAAAGGAAGTT	0.323000													23	34					0	0	1	0	0
FKBP10	60681	broad.mit.edu	37	17	39975475	39975475	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:39975475C>T	ENST00000321562.4	+	5	845	c.741C>T	c.(739-741)ccC>ccT	p.P247P		NM_021939.3	NP_068758.3	Q96AY3	FKB10_HUMAN	FK506 binding protein 10, 65 kDa	247	PPIase FKBP-type 2.				protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		CAGTGATCCCCCCACAGGCCT	0.612000													19	72					0	0	1	0	0
MDFI	4188	broad.mit.edu	37	6	41617376	41617376	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:41617376C>T	ENST00000373050.4	+	3	283	c.96C>T	c.(94-96)ccC>ccT	p.P32P				Q99750	MDFI_HUMAN	MyoD family inhibitor	93					cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|prostate(2)|skin(1)|urinary_tract(1)	8	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			AGGGGAACCCCTTGGGCTGCA	0.647000													70	255					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56424571	56424571	+	Silent	SNP	G	G	A	rs142264094	byFrequency	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:56424571G>A	ENST00000588751.1	-	5	636	c.612C>T	c.(610-612)atC>atT	p.I204I	NLRP13_ENST00000342929.3_Silent_p.I204I			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	204							ATP binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		ATGTATTACGGATATATACGT	0.498000													43	58					0	0	1	0	0
ULK4	54986	broad.mit.edu	37	3	41759338	41759338	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:41759338G>A	ENST00000301831.4	-	23	2799	c.2337C>T	c.(2335-2337)atC>atT	p.I779I		NM_017886.2	NP_060356.2	Q96C45	ULK4_HUMAN	unc-51 like kinase 4	779							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|large_intestine(6)|lung(7)|prostate(5)|skin(1)	22				KIRC - Kidney renal clear cell carcinoma(284;0.214)		TGTCTCTCTCGATGTACATCA	0.448000													13	20					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41004506	41004506	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:41004506C>T	ENST00000399564.4	-	37	4586	c.4136G>A	c.(4135-4137)cGa>cAa	p.R1379Q	MROH2B_ENST00000506092.2_Missense_Mutation_p.R934Q	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		GCTCACGTCTCGGTCTGTCAG	0.463000													35	40					0	0	1	0	0
RNF19B	127544	broad.mit.edu	37	1	33402702	33402702	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:33402702G>T	ENST00000373456.7	-	9	1903	c.1904C>A	c.(1903-1905)cCc>cAc	p.P635H	RNF19B_ENST00000356990.5_3'UTR|RNF19B_ENST00000235150.4_Missense_Mutation_p.P634H	NM_153341.2	NP_699172.2	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B	635						integral to membrane	ligase activity|protein binding|zinc ion binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)	13		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TCTGCAGGGGGGATCCTCTTC	0.567000													29	58					5.45727e-16	5.55595e-16	1	1	0
MAP3K15	389840	broad.mit.edu	37	X	19390897	19390897	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:19390897G>A	ENST00000338883.4	-	22	2981	c.2982C>T	c.(2980-2982)tcC>tcT	p.S994S	MAP3K15_ENST00000359173.3_Silent_p.S429S|MAP3K15_ENST00000518578.1_5'UTR|MAP3K15_ENST00000469203.2_Silent_p.S826S	NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15	994							ATP binding|MAP kinase kinase kinase activity|metal ion binding			NS(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(13)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	Hepatocellular(33;0.183)					TGTCCTCCGGGGACGAGGCCA	0.612000													28	47					0	0	1	0	0
ITPR3	3710	broad.mit.edu	37	6	33647708	33647708	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:33647708C>T	ENST00000374316.5	+	32	5082	c.4022C>T	c.(4021-4023)tCg>tTg	p.S1341L	ITPR3_ENST00000605930.1_Missense_Mutation_p.S1341L			Q14573	ITPR3_HUMAN	inositol 1,4,5-trisphosphate receptor, type 3	1341					activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			NS(1)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(24)|ovary(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	85						GATAAGGCATCGCTGGCCCAC	0.632000													9	27					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128864240	128864240	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:128864240G>A	ENST00000274487.4	+	6	1325	c.1180G>A	c.(1180-1182)Gaa>Aaa	p.E394K	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	394	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GCATCATGGAGAAAAAATGCT	0.353000													12	27					0	0	1	0	0
GSX2	170825	broad.mit.edu	37	4	54968052	54968052	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:54968052C>T	ENST00000326902.2	+	2	1192	c.878C>T	c.(877-879)gCc>gTc	p.A293V	GSX2_ENST00000548609.1_3'UTR|GSX2_ENST00000503800.1_3'UTR|FIP1L1_ENST00000507166.1_Intron	NM_133267.2	NP_573574.1	Q9BZM3	GSX2_HUMAN	GS homeobox 2	293						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(2)|lung(2)	6	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			CTGTCGCCGGCCTCAGCCAAC	0.667000													6	18					0	0	1	0	0
TMEM145	284339	broad.mit.edu	37	19	42818674	42818674	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:42818674G>A	ENST00000598766.1	+	3	297	c.297G>A	c.(295-297)ggG>ggA	p.G99G	TMEM145_ENST00000301204.3_Silent_p.G89G|TMEM145_ENST00000601020.1_3'UTR			Q8NBT3	TM145_HUMAN	transmembrane protein 145	89						integral to membrane				breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	27		Prostate(69;0.00682)				ACAAGGCAGGGGACAAGGTGA	0.617000													57	76					0	0	1	0	0
ACSL3	2181	broad.mit.edu	37	2	223795369	223795369	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:223795369C>T	ENST00000357430.3	+	14	2102	c.1571C>T	c.(1570-1572)cCc>cTc	p.P524L	ACSL3_ENST00000392066.3_Missense_Mutation_p.P524L	NM_004457.3	NP_004448.2	O95573	ACSL3_HUMAN	acyl-CoA synthetase long-chain family member 3	524					long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)|skin(2)	22		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)	AAGCCACACCCCAGGGGTGAA	0.328000			T	ETV1	prostate								2	2					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20248748	20248748	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:20248748G>A	ENST00000315957.4	+	1	348	c.267G>A	c.(265-267)agG>agA	p.R89R		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	89					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R89S(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTGTGGAGAGGAAGATAATTT	0.448000													60	221					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502563	140502563	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140502563G>A	ENST00000194152.1	+	1	983	c.983G>A	c.(982-984)gGa>gAa	p.G328E		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		328	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGCCTTTCTGGAAAAGGCACT	0.418000													60	99					0	0	1	0	0
SPINK6	404203	broad.mit.edu	37	5	147594500	147594500	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:147594500C>T	ENST00000325630.2	+	4	486	c.230C>T	c.(229-231)cCt>cTt	p.P77L		NM_001195290.1|NM_205841.3	NP_001182219.1|NP_995313.2	Q6UWN8	ISK6_HUMAN	serine peptidase inhibitor, Kazal type 6	77	Kazal-like.					extracellular region	serine-type endopeptidase inhibitor activity			endometrium(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTAAAGCATCCTGGAAAATGC	0.378000													12	21					0	0	1	0	0
CCDC81	60494	broad.mit.edu	37	11	86126324	86126324	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:86126324G>T	ENST00000278487.3	+	12	1944	c.865G>T	c.(865-867)Gat>Tat	p.D289Y	CCDC81_ENST00000528728.1_Missense_Mutation_p.D289Y|CCDC81_ENST00000354755.1_Missense_Mutation_p.D464Y|CCDC81_ENST00000445632.2_Missense_Mutation_p.D554Y			Q6ZN84	CCD81_HUMAN	coiled-coil domain containing 81	554										kidney(3)|large_intestine(8)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	20		Acute lymphoblastic leukemia(157;5.51e-06)|all_hematologic(158;0.00535)				CCAGAGGCGGGATTTGCAAAT	0.463000													7	9					2.7689e-08	2.79204e-08	1	1	0
WNK2	65268	broad.mit.edu	37	9	95992139	95992139	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:95992139G>A	ENST00000297954.4	+	2	843	c.843G>A	c.(841-843)ggG>ggA	p.G281G	WNK2_ENST00000395475.2_Silent_p.G267G|WNK2_ENST00000395477.2_Silent_p.G281G|WNK2_ENST00000356055.3_5'UTR|WNK2_ENST00000427277.2_5'UTR|WNK2_ENST00000349097.3_5'UTR			Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	281	Protein kinase.				intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|endometrium(11)|kidney(4)|large_intestine(5)|lung(17)|ovary(2)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)	54						TGACCTCAGGGACGCTGAAGA	0.637000													10	0					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31322904	31322904	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:31322904C>T	ENST00000269197.5	+	12	3092	c.3092C>T	c.(3091-3093)tCc>tTc	p.S1031F		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1031					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						CAACCAGTCTCCAAACCTGAG	0.473000													7	10					0	0	1	0	0
ATP10B	23120	broad.mit.edu	37	5	160061597	160061597	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:160061597G>A	ENST00000327245.5	-	12	1991	c.1145C>T	c.(1144-1146)tCt>tTt	p.S382F	CTC-348L5.1_ENST00000523598.1_RNA	NM_025153.2	NP_079429.2	O94823	AT10B_HUMAN	ATPase, class V, type 10B	382					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(37)|ovary(4)|pancreas(1)|prostate(5)|skin(3)|stomach(1)	75	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GACATACAAAGAGATGGGGAT	0.463000													10	23					0	0	1	0	0
LONRF1	91694	broad.mit.edu	37	8	12595517	12595517	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:12595517G>A	ENST00000398246.3	-	4	1169	c.1100C>T	c.(1099-1101)cCt>cTt	p.P367L	LONRF1_ENST00000533751.1_Missense_Mutation_p.P10L	NM_152271.3	NP_689484.3	Q17RB8	LONF1_HUMAN	LON peptidase N-terminal domain and ring finger 1	367					proteolysis		ATP-dependent peptidase activity|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(1)|upper_aerodigestive_tract(2)	19				READ - Rectum adenocarcinoma(644;0.236)		CTTTGGGCTAGGTTCATTGAG	0.413000													22	32					0	0	1	0	0
TP53AIP1	63970	broad.mit.edu	37	11	128807489	128807489	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:128807489G>A	ENST00000602346.1	-	2	434	c.225C>T	c.(223-225)atC>atT	p.I75I	TP53AIP1_ENST00000531399.1_Intron|TP53AIP1_ENST00000530777.1_Intron|TP53AIP1_ENST00000458238.2_Intron	NM_001251964.1	NP_001238893.1	Q9HCN2	TPIP1_HUMAN	tumor protein p53 regulated apoptosis inducing protein 1	0					apoptosis	mitochondrion				large_intestine(1)|lung(1)|skin(1)	3						GAAAACTTGGGATGTCGGCAC	0.587000													17	36					0	0	1	0	0
BCORL1	63035	broad.mit.edu	37	X	129189888	129189888	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:129189888T>C	ENST00000540052.1	+	12	4957	c.4913T>C	c.(4912-4914)aTc>aCc	p.I1638T	BCORL1_ENST00000359304.2_Missense_Mutation_p.I1508T|BCORL1_ENST00000218147.7_Missense_Mutation_p.I1638T|BCORL1_ENST00000303743.5_Missense_Mutation_p.I1712T	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1638					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						TCCTCGAGGATCTTTCAGGCC	0.572000													59	116					0	0	1	0	0
PNMA3	29944	broad.mit.edu	37	X	152225435	152225435	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:152225435A>T	ENST00000447306.1	+	2	359	c.23A>T	c.(22-24)gAc>gTc	p.D8V	PNMA3_ENST00000370264.4_Missense_Mutation_p.D8V|PNMA3_ENST00000370265.4_Missense_Mutation_p.D8V	NM_013364.4	NP_037496.3	Q9UL41	PNMA3_HUMAN	paraneoplastic Ma antigen 3	8					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	16	Acute lymphoblastic leukemia(192;6.56e-05)					ttgttacaggactggtgtcgg	0.567000													25	48					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10356532	10356532	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:10356532C>T	ENST00000255381.2	-	24	3158	c.3048G>A	c.(3046-3048)atG>atA	p.M1016I	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1016					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TGTCCTCCTCCATCTGCAGGT	0.493000													73	30					0	0	1	0	0
NAV1	89796	broad.mit.edu	37	1	201751991	201751991	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:201751991C>T	ENST00000367296.4	+	6	2771	c.2351C>T	c.(2350-2352)cCt>cTt	p.P784L	NAV1_ENST00000367302.1_Missense_Mutation_p.P797L|NAV1_ENST00000367297.4_Missense_Mutation_p.P784L|NAV1_ENST00000469130.1_3'UTR|NAV1_ENST00000367295.1_Missense_Mutation_p.P393L|IPO9-AS1_ENST00000413035.1_RNA|NAV1_ENST00000367300.3_Missense_Mutation_p.P784L|NAV1_ENST00000295624.6_Missense_Mutation_p.P784L	NM_020443.4	NP_065176.3	Q8NEY1	NAV1_HUMAN	neuron navigator 1	784					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			breast(5)|central_nervous_system(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(10)|lung(29)|ovary(4)|prostate(3)|skin(1)|stomach(2)	70						CCACCAACCCCTCTCAGGTAC	0.542000													16	30					0	0	1	0	0
PTEN	5728	broad.mit.edu	37	10	89653788	89653788	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:89653788A>C	ENST00000371953.3	+	2	1443	c.86A>C	c.(85-87)tAt>tCt	p.Y29S		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	29	Phosphatase tensin-type.				activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.?(8)|p.Y27fs*1(3)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TCAGATATTTATCCAAACATT	0.294000		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			11	6					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35453107	35453107	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:35453107A>G	ENST00000287272.2	+	4	522	c.502A>G	c.(502-504)Agg>Ggg	p.R168G	UNC5D_ENST00000404895.2_Missense_Mutation_p.R168G|UNC5D_ENST00000453357.2_Missense_Mutation_p.R163G|UNC5D_ENST00000420357.1_Missense_Mutation_p.R168G|UNC5D_ENST00000416672.1_Missense_Mutation_p.R168G			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	168	Ig-like C2-type.				apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CCCACAAGGAAGGGAAGTTCC	0.483000													33	46					0	0	1	0	0
FLRT3	23767	broad.mit.edu	37	20	14306245	14306245	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:14306245G>T	ENST00000378053.3	-	2	2164	c.1908C>A	c.(1906-1908)taC>taA	p.Y636*	MACROD2_ENST00000217246.4_Intron|FLRT3_ENST00000341420.4_Nonsense_Mutation_p.Y636*|MACROD2_ENST00000310348.4_Intron	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	636					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		CACTGTCTCTGTAGCTTCGGT	0.418000													28	43					2.47511e-08	2.49728e-08	1	1	0
CD163L1	283316	broad.mit.edu	37	12	7522075	7522075	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:7522075C>T	ENST00000313599.3	-	15	3974	c.3917G>A	c.(3916-3918)gGa>gAa	p.G1306E	CD163L1_ENST00000416109.2_Missense_Mutation_p.G1316E|CD163L1_ENST00000396630.1_Missense_Mutation_p.G1306E			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1306	SRCR 12.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						CCAGATGGTTCCAGTTCCCTG	0.582000													32	59					0	0	1	0	0
MAP1B	4131	broad.mit.edu	37	5	71491772	71491772	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:71491772G>A	ENST00000296755.7	+	5	2888	c.2590G>A	c.(2590-2592)Gaa>Aaa	p.E864K		NM_005909.3	NP_005900.2	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	864						microtubule|microtubule associated complex	structural molecule activity	p.E864K(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(42)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	104		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		AATCGAAGACGAAGAGAAACT	0.493000													38	46					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77651399	77651399	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:77651399G>A	ENST00000461745.1	+	20	3793	c.2893G>A	c.(2893-2895)Gca>Aca	p.A965T	ROBO2_ENST00000487694.3_Missense_Mutation_p.A981T|ROBO2_ENST00000332191.8_Missense_Mutation_p.A965T	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	965					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GGATAAAACAGCAACGATGCT	0.458000													14	29					0	0	1	0	0
ABCF3	55324	broad.mit.edu	37	3	183908823	183908823	+	Silent	SNP	C	C	T	rs151176558	by1000genomes	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:183908823C>T	ENST00000429586.2	+	15	1613	c.1428C>T	c.(1426-1428)gtC>gtT	p.V476V	ABCF3_ENST00000292808.5_Silent_p.V470V|EIF2B5_ENST00000444495.1_Intron	NM_018358.2	NP_060828.2	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 3	476							ATP binding|ATPase activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(20)|ovary(3)|prostate(5)|upper_aerodigestive_tract(1)	39	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AATCAGAGGTCGTAATGAAGT	0.507000													7	22					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34008484	34008484	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:34008484C>T	ENST00000373381.4	-	58	9289	c.9113G>A	c.(9112-9114)gGg>gAg	p.G3038E		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	3013	Sushi 23.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCCAGGGTTCCCACAAGAGAT	0.493000													12	10					0	0	1	0	0
SEMA6B	10501	broad.mit.edu	37	19	4548329	4548329	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:4548329C>T	ENST00000586582.1	-	13	1710	c.1400G>A	c.(1399-1401)gGg>gAg	p.G467E	SEMA6B_ENST00000586965.1_Missense_Mutation_p.G467E|SEMA6B_ENST00000301293.3_Missense_Mutation_p.G467E	NM_032108.3	NP_115484.2	Q9H3T3	SEM6B_HUMAN	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B	467	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0149)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAGACGTCCCTGAGGTGCT	0.647000													22	31					0	0	1	0	0
GABRA3	2556	broad.mit.edu	37	X	151336926	151336926	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:151336926T>G	ENST00000370314.4	-	10	1491	c.1253A>C	c.(1252-1254)aAg>aCg	p.K418T	GABRA3_ENST00000370311.1_Missense_Mutation_p.K418T|RP11-329E24.6_ENST00000453915.1_RNA|GABRA3_ENST00000535043.1_Missense_Mutation_p.K418T	NM_000808.3	NP_000799.1	P34903	GBRA3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 3	418					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	AGCAGCGCCCTTGGAGATGGT	0.557000													72	74					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216405466	216405466	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:216405466G>A	ENST00000366943.2	-	14	3208	c.2822C>T	c.(2821-2823)tCt>tTt	p.S941F	USH2A_ENST00000307340.3_Missense_Mutation_p.S941F|USH2A_ENST00000366942.3_Missense_Mutation_p.S941F			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	941	Laminin EGF-like 8.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ATTGCCTGGAGAAATATAAAA	0.343000										HNSCC(13;0.011)			25	25					0	0	1	0	0
HAS1	3036	broad.mit.edu	37	19	52217175	52217175	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:52217175G>A	ENST00000540069.2	-	5	1299	c.1239C>T	c.(1237-1239)ttC>ttT	p.F413F	HAS1_ENST00000594621.1_3'UTR|HAS1_ENST00000222115.1_Silent_p.F414F|HAS1_ENST00000601714.1_Silent_p.F421F			Q92839	HAS1_HUMAN	hyaluronan synthase 1	414					cell adhesion	integral to plasma membrane	hyaluronan synthase activity|protein binding			breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	40		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00102)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		TGGCCGCCACGAAGAAGGGGA	0.672000													7	18					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559772	140559772	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140559772G>A	ENST00000239444.2	+	1	2402	c.2157G>A	c.(2155-2157)agG>agA	p.R719R		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		719					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAGGAGCAGGGCGGCCTCGG	0.642000													48	70					0	0	1	0	0
PJA2	9867	broad.mit.edu	37	5	108672990	108672990	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:108672990G>A	ENST00000361189.2	-	10	2308	c.2069C>T	c.(2068-2070)tCc>tTc	p.S690F	PJA2_ENST00000361557.3_Missense_Mutation_p.S690F	NM_014819.4	NP_055634.3	O43164	PJA2_HUMAN	praja ring finger 2, E3 ubiquitin protein ligase	690	Interaction with PRKAR1A, PRKAR2A and PRKAR2B.				long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		AGGCTCAGAGGAAGGAGCTGC	0.468000													8	38					0	0	1	0	0
MAP3K14	9020	broad.mit.edu	37	17	43342164	43342164	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:43342164G>A	ENST00000344686.2	-	0	2788				MAP3K14-AS1_ENST00000586450.1_RNA|MAP3K14-AS1_ENST00000585351.1_RNA|MAP3K14-AS1_ENST00000585780.1_RNA|MAP3K14-AS1_ENST00000591263.1_RNA|MAP3K14-AS1_ENST00000585346.1_RNA|MAP3K14-AS1_ENST00000590100.1_RNA|MAP3K14-AS1_ENST00000588504.1_RNA|MAP3K14-AS1_ENST00000588698.1_RNA|MAP3K14-AS1_ENST00000592422.1_RNA|MAP3K14-AS1_ENST00000588160.1_RNA			Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase 14						cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27						GCTGCAGCTGGGATCTAAGGG	0.587000													7	2					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179655490	179655490	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:179655490C>T	ENST00000589042.1	-	11	1969	c.1745G>A	c.(1744-1746)gGa>gAa	p.G582E	TTN_ENST00000360870.5_Missense_Mutation_p.G582E|TTN_ENST00000591111.1_Missense_Mutation_p.G582E|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.G582E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	582							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTTGAGCTCCCGGGACTGT	0.418000													28	17					0	0	1	0	0
C12orf74	338809	broad.mit.edu	37	12	93100482	93100482	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:93100482G>A	ENST00000544406.2	+	2	341	c.75G>A	c.(73-75)agG>agA	p.R25R	C12orf74_ENST00000397833.3_Silent_p.R25R			Q32Q52	CL074_HUMAN	chromosome 12 open reading frame 74	25										kidney(1)|large_intestine(2)|lung(4)|prostate(1)|urinary_tract(2)	10						CCTCGCTGAGGAGCCTGCCAA	0.572000													15	26					0	0	1	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39911445	39911445	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:39911445C>T	ENST00000425673.1	+	13	1677	c.1352C>T	c.(1351-1353)cCt>cTt	p.P451L	PLEKHG2_ENST00000458508.2_Missense_Mutation_p.P392L|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.P451L|PLEKHG2_ENST00000409797.2_Missense_Mutation_p.P451L|PLEKHG2_ENST00000378550.1_Missense_Mutation_p.P451L			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	451					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CTTGGGTCTCCTCGACCTCGA	0.567000													34	64					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97544576	97544576	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:97544576C>T	ENST00000370192.3	-	23	3134	c.3034G>A	c.(3034-3036)Gaa>Aaa	p.E1012K		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	1012					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	CTCTTTGGTTCATAAGGTGTT	0.453000													37	85					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121016635	121016635	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:121016635C>T	ENST00000392793.1	+	12	4186	c.3915C>T	c.(3913-3915)ccC>ccT	p.P1305P	TECTA_ENST00000264037.2_Silent_p.P1305P|TECTA_ENST00000478058.1_3'UTR			O75443	TECTA_HUMAN	tectorin alpha	1305	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCCTGATCCCCAACCAGAACG	0.572000													38	44					0	0	1	0	0
RBM23	55147	broad.mit.edu	37	14	23374321	23374321	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:23374321G>A	ENST00000359890.3	-	8	903	c.708C>T	c.(706-708)atC>atT	p.I236I	RBM23_ENST00000346528.5_Silent_p.I202I|RBM23_ENST00000555209.1_5'UTR|RBM23_ENST00000542016.2_Silent_p.I66I|RBM23_ENST00000399922.2_Silent_p.I220I	NM_001077351.1	NP_001070819.1	Q86U06	RBM23_HUMAN	RNA binding motif protein 23	236	RRM 1.				mRNA processing	nucleus	nucleotide binding|RNA binding			endometrium(3)|kidney(2)|lung(3)|prostate(1)|skin(1)	10	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.0128)		CCTGTACAATGATAGGCACTC	0.527000													17	21					0	0	1	0	0
RNF152	220441	broad.mit.edu	37	18	59483681	59483681	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:59483681G>A	ENST00000312828.3	-	2	1115	c.16C>T	c.(16-18)Cag>Tag	p.Q6*		NM_173557.2	NP_775828.1	Q8N8N0	RN152_HUMAN	ring finger protein 152	6					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding	p.Q6fs*37(1)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)	17		Colorectal(73;0.186)				AGAGAGTCCTGGGACAGCGTC	0.587000													39	39					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141722076	141722076	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:141722076C>T	ENST00000475668.2	+	7	773	c.719C>T	c.(718-720)tCg>tTg	p.S240L	MGAM_ENST00000549489.2_Missense_Mutation_p.S240L			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	240	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AGGTTTGACTCGAGCATTGGG	0.522000													25	25					0	0	1	0	0
COL25A1	84570	broad.mit.edu	37	4	109740464	109740464	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:109740464C>T	ENST00000399132.1	-	36	2397	c.1867G>A	c.(1867-1869)Gaa>Aaa	p.E623K		NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	623	Collagen-like 7.					collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		TCCCCTTTTTCCCCCTTAACG	0.463000													11	23					0	0	1	0	0
LILRB1	10859	broad.mit.edu	37	19	55145110	55145110	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:55145110C>T	ENST00000396331.1	+	9	1640	c.1283C>T	c.(1282-1284)tCc>tTc	p.S428F	LILRB1_ENST00000462628.1_3'UTR|LILRB1_ENST00000434867.2_Missense_Mutation_p.S428F|LILRB1_ENST00000448689.1_Missense_Mutation_p.S428F|LILRB1_ENST00000396317.1_Intron|LILRB1_ENST00000396332.4_Missense_Mutation_p.S428F|LILRB1_ENST00000396321.2_Missense_Mutation_p.S428F|LILRB1_ENST00000427581.2_Missense_Mutation_p.S464F|LILRB1_ENST00000396315.1_Missense_Mutation_p.S428F|LILRB1_ENST00000396327.3_Missense_Mutation_p.S428F|LILRB1_ENST00000324602.7_Missense_Mutation_p.S428F|LILRB1_ENST00000418536.2_Intron	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	428					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		GGCCCCAGCTCCCCGACAACA	0.602000										HNSCC(37;0.09)			4	13					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18747451	18747451	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:18747451C>T	ENST00000433979.1	+	29	4028	c.3912C>T	c.(3910-3912)ttC>ttT	p.F1304F	PIK3C2G_ENST00000538779.1_Silent_p.F1345F|PIK3C2G_ENST00000266497.5_Silent_p.F1304F	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	1304	PX.				cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				TTAGCTTTTTCCTCTCTGAGG	0.289000													11	15					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30093414	30093414	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:30093414G>A	ENST00000567636.1	+	0	1789					NR_003558.1																						CTCCCTTGCTGAACCCTGAGA	0.532000													42	50					0	0	1	0	0
ADAM15	8751	broad.mit.edu	37	1	155028558	155028558	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:155028558C>T	ENST00000356955.2	+	9	848	c.747C>T	c.(745-747)ttC>ttT	p.F249F	ADAM15_ENST00000447332.3_Silent_p.F233F|ADAM15_ENST00000360674.4_Silent_p.F249F|ADAM15_ENST00000359280.4_Silent_p.F249F|ADAM15_ENST00000368410.2_Intron|ADAM15_ENST00000472434.1_3'UTR|ADAM15_ENST00000368412.3_Silent_p.F249F|ADAM15_ENST00000271836.6_Silent_p.F249F|ADAM15_ENST00000449910.2_Silent_p.F249F|ADAM15_ENST00000531455.1_Silent_p.F259F|ADAM15_ENST00000368413.1_Intron|ADAM15_ENST00000355956.2_Silent_p.F249F	NM_207197.2	NP_997080.1	Q13444	ADA15_HUMAN	ADAM metallopeptidase domain 15	249	Peptidase M12B.				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding	p.F249L(1)		NS(1)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(5)|urinary_tract(1)	39	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			TCTTTCAGTTCTTCCGGCCCC	0.627000													16	37					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68993058	68993058	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:68993058G>A	ENST00000288368.4	+	17	2140	c.1863G>A	c.(1861-1863)aaG>aaA	p.K621K	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	621	PDZ 1.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						TGGTAGAAAAGGGATCTAATG	0.274000													6	13					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190067958	190067958	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:190067958C>T	ENST00000367462.3	-	8	1722	c.1491G>A	c.(1489-1491)atG>atA	p.M497I	FAM5C_ENST00000534846.1_Missense_Mutation_p.M395I|FAM5C_ENST00000484105.1_5'UTR	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		497						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GCAGATATTTCATCTCGAGAT	0.498000													49	64					0	0	1	0	0
OR51V1	283111	broad.mit.edu	37	11	5221817	5221817	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:5221817G>A	ENST00000321255.1	-	1	113	c.114C>T	c.(112-114)atC>atT	p.I38I		NM_001004760.2	NP_001004760.2	Q9H2C8	O51V1_HUMAN	olfactory receptor, family 51, subfamily V, member 1	38					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(13)|lung(19)|skin(2)|upper_aerodigestive_tract(2)	39		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.83e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGGAGAAGGGGATGGAAAGCC	0.483000													33	54					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76734939	76734939	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:76734939C>T	ENST00000369963.3	-	4	489	c.300G>A	c.(298-300)gaG>gaA	p.E100E	IMPG1_ENST00000369950.3_Silent_p.E178E			Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	178					visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				TTTCACCAGGCTCTCCCAATG	0.338000													4	8					0	0	1	0	0
MCTP2	55784	broad.mit.edu	37	15	95013640	95013640	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:95013640C>T	ENST00000357742.4	+	20	2439	c.2439C>T	c.(2437-2439)ttC>ttT	p.F813F	MCTP2_ENST00000451018.3_Silent_p.F758F	NM_018349.3	NP_060819.3	Q6DN12	MCTP2_HUMAN	multiple C2 domains, transmembrane 2	813					calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|liver(1)|lung(12)|ovary(1)|pancreas(1)|skin(9)|stomach(2)	49	Lung NSC(78;0.0821)|all_lung(78;0.148)		BRCA - Breast invasive adenocarcinoma(143;0.0323)|OV - Ovarian serous cystadenocarcinoma(32;0.0593)			TTTTGTATTTCATTCCACTGC	0.403000													22	42					0	0	1	0	0
UFSP2	55325	broad.mit.edu	37	4	186336952	186336952	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:186336952C>T	ENST00000264689.6	-	5	519	c.403G>A	c.(403-405)Gaa>Aaa	p.E135K	UFSP2_ENST00000502282.1_5'UTR	NM_018359.3	NP_060829.2	Q9NUQ7	UFSP2_HUMAN	UFM1-specific peptidase 2	135						endoplasmic reticulum|nucleus	small conjugating protein-specific protease activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;0.00109)|Colorectal(36;0.0215)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_hematologic(60;0.0749)		all cancers(43;3.4e-25)|Epithelial(43;2.23e-22)|OV - Ovarian serous cystadenocarcinoma(60;1.54e-11)|BRCA - Breast invasive adenocarcinoma(30;8.1e-05)|GBM - Glioblastoma multiforme(59;0.000148)|STAD - Stomach adenocarcinoma(60;0.000782)|LUSC - Lung squamous cell carcinoma(40;0.00939)|COAD - Colon adenocarcinoma(29;0.0108)|READ - Rectum adenocarcinoma(43;0.166)		CTTTCCCTTTCAATGATGGGC	0.373000													21	24					0	0	1	0	0
CNKSR1	10256	broad.mit.edu	37	1	26515114	26515114	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:26515114C>T	ENST00000531191.1	+	18	1849	c.842C>T	c.(841-843)cCc>cTc	p.P281L	CNKSR1_ENST00000361530.6_Missense_Mutation_p.P539L|CNKSR1_ENST00000374253.5_Missense_Mutation_p.P546L			Q969H4	CNKR1_HUMAN	connector enhancer of kinase suppressor of Ras 1	546	PDZ.				Rho protein signal transduction|transmembrane receptor protein tyrosine kinase signaling pathway	cell cortex|cell-cell junction	protein binding, bridging			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	28		Colorectal(325;3.46e-05)|all_lung(284;0.000116)|Lung NSC(340;0.000154)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0133)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;2.72e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00072)|BRCA - Breast invasive adenocarcinoma(304;0.000959)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00823)|READ - Rectum adenocarcinoma(331;0.0649)		GCTGGGAGTCCCCTCCATGGA	0.632000													9	13					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248309250	248309250	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:248309250C>T	ENST00000366476.1	+	1	801	c.801C>T	c.(799-801)tcC>tcT	p.S267S		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			CTGATCGCTCCCCTATGCAGG	0.517000													35	69					0	0	1	0	0
MUM1L1	139221	broad.mit.edu	37	X	105450013	105450013	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:105450013C>T	ENST00000337685.2	+	5	1373	c.588C>T	c.(586-588)ttC>ttT	p.F196F	MUM1L1_ENST00000357175.2_Silent_p.F196F|MUM1L1_ENST00000372552.1_Silent_p.F196F	NM_152423.4	NP_689636.3	Q5H9M0	MUML1_HUMAN	melanoma associated antigen (mutated) 1-like 1	196										autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31						GCGAGACTTTCCCTTCACTTT	0.393000													5	7					0	0	1	0	0
TMEM222	84065	broad.mit.edu	37	1	27657221	27657221	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:27657221C>T	ENST00000374076.4	+	2	243	c.205C>T	c.(205-207)Ccc>Tcc	p.P69S		NM_032125.2	NP_115501.2	Q9H0R3	TM222_HUMAN	transmembrane protein 222	69						integral to membrane	protein binding			biliary_tract(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	7						GTGGTTTTTCCCCATCATCGG	0.572000													45	70					0	0	1	0	0
KCNQ5	56479	broad.mit.edu	37	6	73904739	73904739	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:73904739G>A	ENST00000342056.2	+	15	2856	c.2458G>A	c.(2458-2460)Gac>Aac	p.D820N	KCNQ5_ENST00000402622.2_Missense_Mutation_p.D811N|KCNQ5_ENST00000355635.3_Missense_Mutation_p.D802N|KCNQ5_ENST00000403813.2_Missense_Mutation_p.D792N|KCNQ5_ENST00000414165.2_Missense_Mutation_p.D691N|KCNQ5_ENST00000355194.4_Missense_Mutation_p.D801N|KCNQ5_ENST00000370398.1_Missense_Mutation_p.D801N	NM_001160132.1|NM_001160133.1	NP_001153604.1|NP_001153605.1	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 5	801					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(1)|cervix(1)|endometrium(6)|kidney(7)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	57		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		TCTCACCAAGGACCGTTCTAT	0.488000													14	11					0	0	1	0	0
LMOD3	56203	broad.mit.edu	37	3	69168543	69168543	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:69168543G>A	ENST00000420581.2	-	2	1142	c.963C>T	c.(961-963)ttC>ttT	p.F321F	LMOD3_ENST00000489031.1_Silent_p.F321F|LMOD3_ENST00000475434.1_Silent_p.F321F	NM_198271.3	NP_938012.2	Q0VAK6	LMOD3_HUMAN	leiomodin 3 (fetal)	321						cytoplasm|cytoskeleton	tropomyosin binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(1)	13		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.88e-05)|Epithelial(33;0.000839)|LUSC - Lung squamous cell carcinoma(21;0.0119)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.205)|Kidney(39;0.24)		TACCTGTGATGAAATTGGACT	0.458000													42	87					0	0	1	0	0
EPG5	57724	broad.mit.edu	37	18	43447663	43447663	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:43447663G>A	ENST00000282041.5	-	37	6310	c.6276C>T	c.(6274-6276)ctC>ctT	p.L2092L	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	2092					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						TGACTTCACAGAGTACAGACC	0.438000													22	28					0	0	1	0	0
BAZ1A	11177	broad.mit.edu	37	14	35272177	35272177	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:35272177C>T	ENST00000360310.1	-	7	1311	c.744G>A	c.(742-744)acG>acA	p.T248T	BAZ1A_ENST00000358716.4_Silent_p.T248T|BAZ1A_ENST00000382422.2_Silent_p.T248T	NM_013448.2	NP_038476.2	Q9NRL2	BAZ1A_HUMAN	bromodomain adjacent to zinc finger domain, 1A	248					chromatin remodeling|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ACF complex	zinc ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(6)|kidney(2)|large_intestine(7)|lung(19)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48	Breast(36;0.0388)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;7.23e-05)|Lung(238;0.00019)|Epithelial(34;0.0793)|all cancers(34;0.175)	GBM - Glioblastoma multiforme(112;0.0659)		CTATTTTATACGTTGAAAGAG	0.373000													17	22					0	0	1	0	0
OR52L1	338751	broad.mit.edu	37	11	6008109	6008109	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:6008109G>A	ENST00000332249.4	-	1	106	c.52C>T	c.(52-54)Ctt>Ttt	p.L18F		NM_001005173.2	NP_001005173.2	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L, member 1	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|pancreas(1)|skin(3)|soft_tissue(1)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAATTGCTAAGGAGCATTATC	0.463000													11	26					0	0	1	0	0
SPOCK3	50859	broad.mit.edu	37	4	167983673	167983673	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:167983673T>G	ENST00000357154.3	-	4	351	c.214A>C	c.(214-216)Act>Cct	p.T72P	SPOCK3_ENST00000510741.1_Missense_Mutation_p.T69P|SPOCK3_ENST00000421836.2_Missense_Mutation_p.T21P|SPOCK3_ENST00000507137.1_5'UTR|SPOCK3_ENST00000511531.1_Missense_Mutation_p.T72P|SPOCK3_ENST00000504953.1_Missense_Mutation_p.T69P|SPOCK3_ENST00000541637.1_Intron|SPOCK3_ENST00000511269.1_Missense_Mutation_p.T69P|SPOCK3_ENST00000541354.1_5'UTR|SPOCK3_ENST00000535728.1_5'UTR|SPOCK3_ENST00000502330.1_Missense_Mutation_p.T72P|SPOCK3_ENST00000534949.1_Intron|SPOCK3_ENST00000357545.4_Missense_Mutation_p.T69P|SPOCK3_ENST00000512648.1_Missense_Mutation_p.T69P|SPOCK3_ENST00000512681.1_Intron|SPOCK3_ENST00000506886.1_Missense_Mutation_p.T72P	NM_016950.2	NP_058646.2	Q9BQ16	TICN3_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	72					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		GGACTCCAAGTGCGGAAATAA	0.294000													16	26					0	0	1	0	0
IGKV1-27	28935	broad.mit.edu	37	2	89513022	89513022	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:89513022C>T	ENST00000498435.1	-	0	267																											GAGATGGGACCCCTGATTGCA	0.488000													37	18					0	0	1	0	0
RGS7	6000	broad.mit.edu	37	1	241031894	241031894	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:241031894C>A	ENST00000366565.1	-	9	983	c.602G>T	c.(601-603)aGg>aTg	p.R201M	RGS7_ENST00000366562.4_Missense_Mutation_p.R201M|RGS7_ENST00000348120.2_Missense_Mutation_p.R148M|RGS7_ENST00000446183.2_Missense_Mutation_p.R117M|RGS7_ENST00000407727.1_Missense_Mutation_p.R201M|RGS7_ENST00000366564.1_Missense_Mutation_p.R201M|RGS7_ENST00000401882.1_Missense_Mutation_p.R148M|RGS7_ENST00000331110.7_Missense_Mutation_p.R175M|RGS7_ENST00000366563.1_Missense_Mutation_p.R201M	NM_002924.4	NP_002915.3	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	201					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(51)|ovary(4)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			TACCACGGGCCTGTGCACGTC	0.498000													11	35					5.50884e-06	5.53176e-06	1	1	0
PTPN9	5780	broad.mit.edu	37	15	75798234	75798234	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:75798234G>A	ENST00000306726.2	-	7	1262	c.750C>T	c.(748-750)ttC>ttT	p.F250F		NM_002833.2	NP_002824.1	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type 9	250						cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CCTGGGGTAGGAACTGGAAAT	0.537000													10	20					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135427550	135427550	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:135427550C>T	ENST00000394143.1	+	6	1976	c.1685C>T	c.(1684-1686)tCc>tTc	p.S562F	GPR112_ENST00000287534.4_Missense_Mutation_p.S499F|GPR112_ENST00000412101.1_Missense_Mutation_p.S357F|GPR112_ENST00000370652.1_Missense_Mutation_p.S562F|GPR112_ENST00000394141.1_Missense_Mutation_p.S357F	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	562					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TTCTTAACATCCTTTTCATTT	0.418000													7	30					0	0	1	0	0
C6orf10	10665	broad.mit.edu	37	6	32260967	32260967	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:32260967C>T	ENST00000375015.4	-	26	1680	c.1480G>A	c.(1480-1482)Gat>Aat	p.D494N	C6orf10_ENST00000375007.4_Missense_Mutation_p.D493N|C6orf10_ENST00000447241.2_Missense_Mutation_p.D495N|C6orf10_ENST00000442822.2_Intron|C6orf10_ENST00000527965.1_Missense_Mutation_p.D479N|C6orf10_ENST00000533191.1_Missense_Mutation_p.D493N			Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	495	Lys-rich.					integral to membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	25						tttcctttATCCTCAAAACTC	0.378000													39	100					0	0	1	0	0
ZNF799	90576	broad.mit.edu	37	19	12501361	12501361	+	Silent	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:12501361T>C	ENST00000419318.1	-	4	2504	c.1755A>G	c.(1753-1755)ggA>ggG	p.G585G	CTD-3105H18.14_ENST00000435033.1_Intron|ZNF799_ENST00000430385.3_Silent_p.G617G			Q96GE5	ZN799_HUMAN	zinc finger protein 799	617					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(2)|prostate(2)|skin(2)	19						ACGGGTTCTCTCCAGTGTGAG	0.403000													32	55					0	0	1	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52716281	52716281	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:52716281C>T	ENST00000322088.6	+	6	783	c.725C>T	c.(724-726)gCc>gTc	p.A242V	PPP2R1A_ENST00000462990.1_Missense_Mutation_p.A63V|PPP2R1A_ENST00000444322.2_Missense_Mutation_p.A187V	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	242	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		GATCTGGAGGCCCTGGTGATG	0.637000			Mis		clear cell ovarian carcinoma								12	30					0	0	1	0	0
WFS1	7466	broad.mit.edu	37	4	6304174	6304174	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:6304174C>T	ENST00000226760.1	+	8	2822	c.2652C>T	c.(2650-2652)ttC>ttT	p.F884F	WFS1_ENST00000503569.1_Silent_p.F884F	NM_001145853.1|NM_006005.3	NP_001139325.1|NP_005996.2	O76024	WFS1_HUMAN	Wolfram syndrome 1 (wolframin)	884	Poly-Phe.				endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	21				Colorectal(103;0.0512)		TCTTTTTCTTCCCATTCCTGT	0.632000													13	27					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66468383	66468383	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:66468383C>T	ENST00000533211.1	-	17	3518	c.3187G>A	c.(3187-3189)Gag>Aag	p.E1063K	SPTBN2_ENST00000309996.2_Missense_Mutation_p.E1063K|SPTBN2_ENST00000529997.1_Missense_Mutation_p.E1063K			O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1063					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						CGCCGCGCCTCCCCCAGCGAC	0.677000													19	18					0	0	1	0	0
TNRC6A	27327	broad.mit.edu	37	16	24831582	24831582	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:24831582C>A	ENST00000395799.3	+	22	5332	c.5203C>A	c.(5203-5205)Ccg>Acg	p.P1735T	TNRC6A_ENST00000432286.2_Missense_Mutation_p.P213T|TNRC6A_ENST00000315183.7_Missense_Mutation_p.P1686T	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1735	Sufficient for interaction with EIF2C2.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		CCGCCCACCTCCGGGACTGAC	0.542000													17	40					2.37509e-13	2.40933e-13	1	1	0
SLC7A6OS	84138	broad.mit.edu	37	16	68338067	68338067	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:68338067C>T	ENST00000263997.6	-	3	558	c.540G>A	c.(538-540)gaG>gaA	p.E180E		NM_032178.2	NP_115554.2	Q96CW6	S7A6O_HUMAN	solute carrier family 7, member 6 opposite strand	180					protein transport	cytoplasm|nucleus				breast(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(1)	10		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.106)		CTGGTCCATCCTCAGACACAG	0.478000													38	60					0	0	1	0	0
DAG1	1605	broad.mit.edu	37	3	49568863	49568863	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:49568863C>T	ENST00000545947.1	+	6	1641	c.919C>T	c.(919-921)Ccc>Tcc	p.P307S	DAG1_ENST00000308775.2_Missense_Mutation_p.P307S|DAG1_ENST00000538711.1_Missense_Mutation_p.P307S|DAG1_ENST00000541308.1_Missense_Mutation_p.P307S|DAG1_ENST00000539901.1_Missense_Mutation_p.P307S|DAG1_ENST00000515359.2_Missense_Mutation_p.P307S	NM_001177634.2	NP_001171105.1	Q14118	DAG1_HUMAN	dystroglycan 1 (dystrophin-associated glycoprotein 1)	307	Required for laminin recognition.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of cell migration|negative regulation of MAPKKK cascade|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			NS(1)|autonomic_ganglia(2)|breast(2)|endometrium(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GCCCCCTCTTCCCAAACGCGT	0.617000													21	31					0	0	1	0	0
NHS	4810	broad.mit.edu	37	X	17746424	17746424	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:17746424A>T	ENST00000380060.3	+	6	4473	c.4135A>T	c.(4135-4137)Aat>Tat	p.N1379Y	NHS_ENST00000398097.3_Missense_Mutation_p.N1223Y	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	1379						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					GACCCAAGGAAATGTGGATGA	0.393000													8	10					0	0	1	0	0
ATP6V0A1	535	broad.mit.edu	37	17	40652901	40652901	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:40652901C>T	ENST00000343619.4	+	16	1979	c.1856C>T	c.(1855-1857)tCc>tTc	p.S619F	ATP6V0A1_ENST00000264649.6_Missense_Mutation_p.S626F|ATP6V0A1_ENST00000585525.1_Missense_Mutation_p.S576F|ATP6V0A1_ENST00000393829.2_Missense_Mutation_p.S619F|ATP6V0A1_ENST00000546249.1_Missense_Mutation_p.S619F|ATP6V0A1_ENST00000544137.1_Missense_Mutation_p.S265F|ATP6V0A1_ENST00000537728.1_Missense_Mutation_p.S576F	NM_001130021.1	NP_001123493.1	Q93050	VPP1_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a1	619					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytoplasmic vesicle membrane|endosome membrane|Golgi apparatus|integral to membrane|melanosome|nucleus|plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|urinary_tract(3)	26		all_cancers(22;1.18e-05)|Breast(137;0.000105)|all_epithelial(22;0.000254)		BRCA - Breast invasive adenocarcinoma(366;0.137)		TTCCTCTTTTCCTACCCAGAG	0.428000													45	60					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92487982	92487982	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:92487982G>A	ENST00000267622.4	-	4	879	c.506C>T	c.(505-507)tCa>tTa	p.S169L		NM_004239.3	NP_004230.2	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	169					transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		TTGTTGGGATGAAATTATATC	0.393000			T	PDGFRB	AML								11	22					0	0	1	0	0
CYFIP1	23191	broad.mit.edu	37	15	22962505	22962505	+	Missense_Mutation	SNP	C	C	T	rs139576657		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:22962505C>T	ENST00000313077.7	+	20	2350	c.2225C>T	c.(2224-2226)cCg>cTg	p.P742L	CYFIP1_ENST00000560848.1_Missense_Mutation_p.P742L|CYFIP1_ENST00000435939.2_Missense_Mutation_p.P311L	NM_014608.2	NP_055423.1	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1	742					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(1)|lung(14)|ovary(4)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	40		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		CACCTCCCGCCGTCTAACCGC	0.522000													12	12					0	0	1	0	0
C4orf21	55345	broad.mit.edu	37	4	113506747	113506747	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:113506747G>A	ENST00000505019.1	-	14	4176	c.4051C>T	c.(4051-4053)Cat>Tat	p.H1351Y		NM_018392.4	NP_060862.3	Q86YA3	CD021_HUMAN	chromosome 4 open reading frame 21	0										breast(1)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(6)|lung(21)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		GGTTGACTATGATGGCAGGAT	0.373000													7	6					0	0	1	0	0
NOL4	8715	broad.mit.edu	37	18	31538328	31538328	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:31538328G>A	ENST00000261592.5	-	7	1408	c.1111C>T	c.(1111-1113)Cga>Tga	p.R371*	NOL4_ENST00000535475.1_Nonsense_Mutation_p.R216*|NOL4_ENST00000538587.1_Nonsense_Mutation_p.R297*|NOL4_ENST00000535384.1_Nonsense_Mutation_p.R86*|NOL4_ENST00000269185.4_Nonsense_Mutation_p.R257*|NOL4_ENST00000589544.1_Nonsense_Mutation_p.R371*	NM_001198546.1|NM_003787.4	NP_001185475.1|NP_003778.2	O94818	NOL4_HUMAN	nucleolar protein 4	371						nucleolus	RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(20)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	51						TCAGCTCCTCGGTCTACACTC	0.458000													33	66					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196577388	196577388	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:196577388G>A	ENST00000367433.5	-	1	153	c.52C>T	c.(52-54)Cga>Tga	p.R18*	KCNT2_ENST00000451324.2_5'UTR|KCNT2_ENST00000367431.4_Nonsense_Mutation_p.R18*|KCNT2_ENST00000294725.8_Nonsense_Mutation_p.R18*			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	18						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						AGCAAATCTCGAAACCTGTAC	0.493000													18	30					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027036	37027036	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:37027036G>A	ENST00000358047.3	+	1	605	c.553G>A	c.(553-555)Gaa>Aaa	p.E185K		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	185										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						CCCCTGTGGGGAATTCTCCCC	0.647000													8	15					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196967406	196967406	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:196967406G>A	ENST00000367414.5	+	7	1247	c.1191G>A	c.(1189-1191)ggG>ggA	p.G397G	CFHR5_ENST00000256785.4_Silent_p.G373G	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	373	Sushi 7.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						GTATAAACGGGAAATGGAATC	0.323000													8	11					0	0	1	0	0
OTUD3	23252	broad.mit.edu	37	1	20231456	20231456	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:20231456C>T	ENST00000375120.3	+	6	812	c.811C>T	c.(811-813)Cgg>Tgg	p.R271W		NM_015207.1	NP_056022.1	Q5T2D3	OTUD3_HUMAN	OTU domain containing 3	271										breast(1)|kidney(2)|large_intestine(4)|lung(1)|skin(1)	9		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000276)|Lung NSC(340;0.000338)|Breast(348;0.000812)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.12e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000142)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.000408)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)		TGCCGTGCTTCGGATGAACCA	0.294000													19	30					0	0	1	0	0
MYOC	4653	broad.mit.edu	37	1	171605754	171605754	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:171605754G>A	ENST00000037502.5	-	3	885	c.826C>T	c.(826-828)Ccc>Tcc	p.P276S		NM_000261.1	NP_000252.1	Q99972	MYOC_HUMAN	myocilin, trabecular meshwork inducible glucocorticoid response	276	Olfactomedin-like.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(1)|urinary_tract(2)	28	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					GGGTAGGTGGGCTTGGGGTCT	0.527000													20	31					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725813	140725813	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140725813C>T	ENST00000253812.6	+	1	2213	c.2213C>T	c.(2212-2214)tCg>tTg	p.S738L	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCCCGGCTCGCACTTTGTG	0.667000													50	58					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	99690418	99690418	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:99690418C>T	ENST00000524871.1	+	4	489	c.199C>T	c.(199-201)Ccc>Tcc	p.P67S	CNTN5_ENST00000527185.1_Missense_Mutation_p.P67S|CNTN5_ENST00000279463.3_Missense_Mutation_p.P67S|CNTN5_ENST00000418526.2_Intron|CNTN5_ENST00000528682.1_Missense_Mutation_p.P67S	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	67					cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TGCTTCTTCACCCAGCTGGCT	0.423000													7	28					0	0	1	0	0
MUC21	394263	broad.mit.edu	37	6	30954320	30954320	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:30954320C>T	ENST00000376296.3	+	2	609	c.368C>T	c.(367-369)tCt>tTt	p.S123F	MUC21_ENST00000486149.2_5'UTR	NM_001010909.2	NP_001010909.2	Q5SSG8	MUC21_HUMAN	mucin 21, cell surface associated	123	28 X 15 AA approximate tandem repeats.|Ser-rich.					integral to membrane|plasma membrane				NS(4)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	42						GCCACCAACTCTGAGTCCAGC	0.602000													75	172					0	0	1	0	0
PRB3	5544	broad.mit.edu	37	12	11420863	11420863	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:11420863C>T	ENST00000381842.3	-	0	357				PRB3_ENST00000279573.6_RNA|PRB3_ENST00000538488.1_RNA|PRB3_ENST00000440870.3_RNA	NM_006249.4	NP_006240.4	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3							extracellular region	Gram-negative bacterial cell surface binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(5)	25			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GGACTGGTTTCCTCCTTGTGG	0.632000													144	171					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124934394	124934394	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:124934394G>A	ENST00000356219.3	-	8	937	c.782C>T	c.(781-783)tCc>tTc	p.S261F	NCOR2_ENST00000405201.1_Missense_Mutation_p.S261F|NCOR2_ENST00000429285.2_Missense_Mutation_p.S261F|NCOR2_ENST00000404121.2_5'UTR|NCOR2_ENST00000404621.1_Missense_Mutation_p.S261F|NCOR2_ENST00000397355.1_Missense_Mutation_p.S261F	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	261	Interaction with SIN3A/B (By similarity).				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CCGGGTGTCGGAGGGCTGGTT	0.622000													11	16					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146471397	146471397	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:146471397C>T	ENST00000361727.3	+	2	648	c.132C>T	c.(130-132)ccC>ccT	p.P44P		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	44	F5/8 type C.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			CTGGACTCCCCCATGTGGCTT	0.438000										HNSCC(39;0.1)			6	19					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34089009	34089009	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:34089009C>T	ENST00000373381.4	-	36	5859	c.5683G>A	c.(5683-5685)Ggt>Agt	p.G1895S	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373380.1_Missense_Mutation_p.G768S|CSMD2_ENST00000373377.1_5'UTR	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1855	CUB 11.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TTATCTGCACCATCAAATACT	0.483000													9	14					0	0	1	0	0
RPS6KA3	6197	broad.mit.edu	37	X	20174290	20174290	+	Silent	SNP	G	G	A	rs147566276		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:20174290G>A	ENST00000379565.3	-	21	2244	c.2037C>T	c.(2035-2037)atC>atT	p.I679I	RPS6KA3_ENST00000544447.1_Silent_p.I651I|RPS6KA3_ENST00000540702.1_Silent_p.I650I|RPS6KA3_ENST00000479809.1_5'UTR|RPS6KA3_ENST00000379548.4_Silent_p.I649I	NM_004586.2	NP_004577.1	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 3	679	Protein kinase 2.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			breast(4)|central_nervous_system(4)|endometrium(3)|kidney(2)|large_intestine(5)|liver(14)|lung(7)|ovary(1)|stomach(1)	41						CCCAGTGGACGATCCAAGGAT	0.473000													39	49					0	0	1	0	0
TSPYL2	64061	broad.mit.edu	37	X	53114471	53114471	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:53114471G>A	ENST00000375442.4	+	5	1338	c.1206G>A	c.(1204-1206)agG>agA	p.R402R		NM_022117.3	NP_071400.1	Q9H2G4	TSYL2_HUMAN	TSPY-like 2	402					cell cycle|chromatin modification|negative regulation of cell cycle|negative regulation of cell growth|negative regulation of DNA replication|nucleosome assembly|regulation of protein kinase activity|regulation of signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|rDNA binding			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(1)	19						GGGGCTCCAGGATAAAGAGAA	0.443000													8	19					0	0	1	0	0
PPRC1	23082	broad.mit.edu	37	10	103898670	103898670	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:103898670C>A	ENST00000278070.2	+	4	563	c.524C>A	c.(523-525)cCa>cAa	p.P175Q	PPRC1_ENST00000413464.2_Missense_Mutation_p.P175Q	NM_015062.3	NP_055877.3	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator-related 1	175					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(10)|lung(19)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CGGACACCCCCAGAACGTGAC	0.542000													17	9					1.45105e-14	1.47551e-14	1	1	0
TRIOBP	11078	broad.mit.edu	37	22	38119355	38119355	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:38119355G>A	ENST00000406386.3	+	7	1047	c.792G>A	c.(790-792)agG>agA	p.R264R	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	264					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					CTGCCCAAAGGGACACTGCTC	0.607000													34	30					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34148068	34148068	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:34148068C>T	ENST00000346193.3	-	1	2379	c.2328G>A	c.(2326-2328)atG>atA	p.M776I		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	776										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						TGTAAAATATCATTGCACGTT	0.388000													28	32					0	0	1	0	0
NUPL1	9818	broad.mit.edu	37	13	25887865	25887865	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:25887865C>T	ENST00000463407.1	+	5	693	c.550C>T	c.(550-552)Cag>Tag	p.Q184*	NUPL1_ENST00000381736.3_Nonsense_Mutation_p.Q184*|NUPL1_ENST00000381718.3_Nonsense_Mutation_p.Q172*|NUPL1_ENST00000466694.1_3'UTR			Q9BVL2	NUPL1_HUMAN	nucleoporin like 1	184	14 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore				breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|stomach(1)|urinary_tract(1)	16		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		TTCACTTTTCCAGAGTACAAA	0.358000													26	48					0	0	1	0	0
MUCL1	118430	broad.mit.edu	37	12	55248369	55248369	+	Translation_Start_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:55248369G>A	ENST00000308796.6	+	1	49	c.3G>A	c.(1-3)atG>atA	p.M1I	MUCL1_ENST00000547990.1_Intron|MUCL1_ENST00000546809.1_Intron	NM_058173.2	NP_477521.1	Q96DR8	MUCL1_HUMAN	mucin-like 1	1						extracellular region|membrane				breast(1)|kidney(1)|lung(1)	3						TCACCACCATGAAGTTCTTAG	0.438000													10	16					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41552766	41552766	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:41552766G>A	ENST00000396942.1	-	27	3127	c.3044C>T	c.(3043-3045)tCc>tTc	p.S1015F	ANK1_ENST00000379758.2_Missense_Mutation_p.S1015F|ANK1_ENST00000396945.1_Missense_Mutation_p.S1015F|ANK1_ENST00000347528.4_Missense_Mutation_p.S1015F|ANK1_ENST00000289734.7_Missense_Mutation_p.S1015F|ANK1_ENST00000265709.8_Missense_Mutation_p.S1056F|ANK1_ENST00000352337.4_Missense_Mutation_p.S1015F			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1015	ZU5.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CTTCCACACGGAGCCGTTTTC	0.622000													40	79					0	0	1	0	0
FAM66D	100132923	broad.mit.edu	37	8	11985975	11985975	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:11985975G>A	ENST00000434078.2	+	0	608					NR_027425.1																						TCAAGACAAGGATGAGGACCT	0.478000													15	38					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50248635	50248635	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:50248635C>T	ENST00000246801.3	-	7	1093	c.1011G>A	c.(1009-1011)ctG>ctA	p.L337L	TSKS_ENST00000358830.3_Silent_p.L137L	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	337							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		ACCGGGCGGTCAGTGAGGACA	0.687000													3	10					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55568842	55568842	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:55568842C>T	ENST00000395445.1	-	36	5362	c.4968G>A	c.(4966-4968)agG>agA	p.R1656R	PCDH15_ENST00000395440.1_Silent_p.R590R|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000409834.1_3'UTR|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395438.1_3'UTR|PCDH15_ENST00000395442.1_Silent_p.R521R|PCDH15_ENST00000395446.1_Silent_p.R852R	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CAATGTTTTTCCTTGCTTTTT	0.468000										HNSCC(58;0.16)			10	4					0	0	1	0	0
PHACTR1	221692	broad.mit.edu	37	6	12749949	12749949	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:12749949C>T	ENST00000379350.1	+	3	306	c.177C>T	c.(175-177)ccC>ccT	p.P59P	PHACTR1_ENST00000379348.2_Silent_p.P59P|PHACTR1_ENST00000332995.7_Silent_p.P59P			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	59						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			ACCGGCGGCCCATCCGGAGAG	0.662000													15	34					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262979	140262979	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140262979G>A	ENST00000289272.2	+	1	1126	c.1126G>A	c.(1126-1128)Gat>Aat	p.D376N	PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.D376N|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1												p.D376Y(1)|p.D376N(1)		NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTGTGTCCGATCGTGACTC	0.502000													39	44					0	0	1	0	0
ZNF786	136051	broad.mit.edu	37	7	148769369	148769369	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:148769369G>A	ENST00000316286.9	-	3	509	c.237C>T	c.(235-237)atC>atT	p.I79I	ZNF786_ENST00000491431.1_Silent_p.I165I|ZNF786_ENST00000451334.3_Silent_p.I128I			Q8N393	ZN786_HUMAN	zinc finger protein 786	165	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|cervix(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(2)	26	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TGGGACCTGGGATTCCTTCTT	0.612000													3	8					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16034826	16034826	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:16034826C>T	ENST00000326742.7	-	6	715	c.714G>A	c.(712-714)caG>caA	p.Q238Q	CYP4F11_ENST00000402119.3_Silent_p.Q238Q|CYP4F11_ENST00000248041.7_Silent_p.Q238Q			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	238					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						GCAAGAGAATCTGCTGGTTTC	0.507000													32	42					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600384	29600384	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:29600384G>A	ENST00000431530.3	+	1	1637	c.1579G>A	c.(1579-1581)Gat>Aat	p.D527N		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	517						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						AGAGAATGCAGATAAGATTGA	0.507000													13	44					0	0	1	0	0
DAB1	1600	broad.mit.edu	37	1	57756691	57756691	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:57756691C>T	ENST00000371236.2	-	2	275	c.12G>A	c.(10-12)gaG>gaA	p.E4E	DAB1_ENST00000420954.2_Silent_p.E4E|DAB1_ENST00000439789.2_Silent_p.E4E|DAB1_ENST00000414851.2_Silent_p.E4E|DAB1_ENST00000371234.4_Silent_p.E4E|DAB1_ENST00000371230.1_Silent_p.E4E|DAB1_ENST00000485760.1_5'UTR|DAB1_ENST00000371231.1_Silent_p.E4E			O75553	DAB1_HUMAN	Dab, reelin signal transducer, homolog 1 (Drosophila)	4					cell differentiation|nervous system development					central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(5)|urinary_tract(5)	64						GAAGTTCTGTCTCAGTTGACA	0.463000													17	20					0	0	1	0	0
GLIS3	169792	broad.mit.edu	37	9	3856009	3856009	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:3856009C>T	ENST00000324333.10	-	8	2201	c.2008_splice	c.e8+1	p.G670_splice	GLIS3_ENST00000461870.1_5'UTR|GLIS3_ENST00000381971.3_Splice_Site_p.G825_splice	NM_152629.3	NP_689842.3	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3	670					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(12)|lung(4)|ovary(2)|prostate(1)|skin(1)	26		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		TCTTGCTTACCATGGACATGG	0.443000													20	20					0	0	1	0	0
EPHA8	2046	broad.mit.edu	37	1	22902907	22902907	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:22902907G>A	ENST00000166244.3	+	3	429	c.357G>A	c.(355-357)aaG>aaA	p.K119K	EPHA8_ENST00000374644.4_Silent_p.K119K|EPHA8_ENST00000538803.1_Silent_p.K119K	NM_020526.3	NP_065387.1	P29322	EPHA8_HUMAN	EPH receptor A8	119						integral to plasma membrane	ATP binding|ephrin receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(6)|lung(22)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		GCACCTGCAAGGAGACCTTCA	0.617000													14	27					0	0	1	0	0
FCGR3B	2215	broad.mit.edu	37	1	161600943	161600943	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:161600943C>T	ENST00000531221.1	-	1	53	c.50G>A	c.(49-51)gGc>gAc	p.G17D	FCGR2B_ENST00000428605.2_Intron|FCGR2B_ENST00000403078.3_Intron|FCGR2B_ENST00000367960.5_Intron|FCGR2B_ENST00000367962.4_Intron|FCGR3B_ENST00000367964.2_Intron|FCGR3B_ENST00000294800.3_5'UTR			O75015	FCG3B_HUMAN	Fc fragment of IgG, low affinity IIIb, receptor (CD16b)	0					immune response	anchored to membrane|extracellular region|plasma membrane	IgG binding|receptor activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(9)|prostate(1)|urinary_tract(1)	18	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AGGGACCAAGCCGACTAGACA	0.512000													10	9					0	0	1	0	0
EPHB3	2049	broad.mit.edu	37	3	184298273	184298273	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:184298273G>A	ENST00000330394.2	+	12	2708	c.2256G>A	c.(2254-2256)atG>atA	p.M752I	EIF2B5_ENST00000444495.1_Intron	NM_004443.3	NP_004434.2	P54753	EPHB3_HUMAN	EPH receptor B3	752	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(22)|ovary(5)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	51	all_cancers(143;1.89e-10)|Ovarian(172;0.0339)		Epithelial(37;1.27e-34)|OV - Ovarian serous cystadenocarcinoma(80;3.8e-22)			TGTCCGAGATGAACTATGTGC	0.577000													38	60					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9923500	9923500	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:9923500C>T	ENST00000396573.2	-	10	2096	c.1787G>A	c.(1786-1788)gGg>gAg	p.G596E	GRIN2A_ENST00000330684.3_Missense_Mutation_p.G596E|GRIN2A_ENST00000396575.2_Missense_Mutation_p.G596E|GRIN2A_ENST00000535259.1_Missense_Mutation_p.G439E|GRIN2A_ENST00000562109.1_Missense_Mutation_p.G596E|GRIN2A_ENST00000404927.2_Missense_Mutation_p.G596E	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	596					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AAAAGAAGGCCCATGGGGTGC	0.478000													14	10					0	0	1	0	0
PKLR	5313	broad.mit.edu	37	1	155263367	155263367	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:155263367C>T	ENST00000392414.3	-	8	1151	c.1038G>A	c.(1036-1038)atG>atA	p.M346I	PKLR_ENST00000342741.4_Missense_Mutation_p.M377I	NM_181871.3	NP_870986.1	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC	377					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	GCTTGGTAATCATGCTCTCCA	0.582000													12	18					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32745802	32745802	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:32745802C>T	ENST00000333070.4	+	12	1508	c.1408C>T	c.(1408-1410)Cct>Tct	p.P470S	LCK_ENST00000336890.5_Missense_Mutation_p.P440S|LCK_ENST00000373564.3_Missense_Mutation_p.P447S	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	440	Protein kinase.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	CGGCCGCATCCCTTACCCAGG	0.507000			T	TRB@	T-ALL								15	15					0	0	1	0	0
HADHB	3032	broad.mit.edu	37	2	26508288	26508288	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:26508288C>T	ENST00000317799.5	+	15	1342	c.1238C>T	c.(1237-1239)cCt>cTt	p.P413L	HADHB_ENST00000405867.3_Missense_Mutation_p.P290L|HADHB_ENST00000545822.1_Missense_Mutation_p.P391L|HADHB_ENST00000537713.1_Missense_Mutation_p.P398L|HADHB_ENST00000494615.1_3'UTR	NM_000183.2	NP_000174.1	P55084	ECHB_HUMAN	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit	413					fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGATTGCCTCCTTTGGAGAAG	0.473000													17	5					0	0	1	0	0
OR4A47	403253	broad.mit.edu	37	11	48510938	48510938	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:48510938G>A	ENST00000446524.1	+	1	670	c.594G>A	c.(592-594)gtG>gtA	p.V198V		NM_001005512.2	NP_001005512.2	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A, member 47	198					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(18)|ovary(1)|skin(1)|urinary_tract(2)	29						TCTTAGTGGTGGCCAATGGAG	0.448000													56	58					0	0	1	0	0
DMD	1756	broad.mit.edu	37	X	31893359	31893359	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:31893359C>T	ENST00000357033.4	-	48	7250	c.7044G>A	c.(7042-7044)agG>agA	p.R2348R	DMD_ENST00000359836.1_5'UTR|DMD_ENST00000378677.2_Silent_p.R2344R|DMD_ENST00000474231.1_5'UTR|DMD_ENST00000343523.2_5'UTR|DMD_ENST00000541735.1_5'UTR|DMD_ENST00000378707.3_5'UTR	NM_000109.3|NM_004006.2|NM_004007.2|NM_004011.3|NM_004012.3|NM_004014.2	NP_000100.2|NP_003997.1|NP_003998.1|NP_004002.2|NP_004003.1|NP_004005.1	P11532	DMD_HUMAN	dystrophin	2348			Missing (in DMD).		muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding	p.R2348K(1)|p.R2343R(1)|p.R1007K(1)|p.R2343K(1)|p.R1007R(1)|p.R2348R(1)|p.R2344K(1)|p.R2344R(1)		NS(2)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|liver(1)|lung(25)|ovary(3)|pancreas(3)|prostate(2)|skin(1)|urinary_tract(2)	77		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CCAACTGATTCCTAATAGGAG	0.338000													8	15					0	0	1	0	0
TFAP2D	83741	broad.mit.edu	37	6	50681780	50681780	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:50681780C>T	ENST00000008391.3	+	1	240	c.12C>T	c.(10-12)acC>acT	p.T4T		NM_172238.3	NP_758438.2	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 delta (activating enhancer binding protein 2 delta)	4							DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(12)|lung(26)|ovary(6)|pancreas(1)|prostate(5)|stomach(1)	60	Lung NSC(77;0.0334)					TGTCAACTACCTTTCCGGGAC	0.458000													11	64					0	0	1	0	0
ANKRD45	339416	broad.mit.edu	37	1	173616117	173616117	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:173616117G>A	ENST00000333279.2	-	3	424	c.364C>T	c.(364-366)Cgt>Tgt	p.R122C		NM_198493.2	NP_940895.1	Q5TZF3	ANR45_HUMAN	ankyrin repeat domain 45	138										NS(2)|endometrium(2)|large_intestine(4)|lung(3)|skin(1)	12						GTTTCCAAACGACCCCAGGCT	0.413000													11	27					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38723782	38723782	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:38723782A>T	ENST00000359357.3	+	8	1045	c.791A>T	c.(790-792)aAt>aTt	p.N264I	DNAH8_ENST00000449981.2_Missense_Mutation_p.N481I|DNAH8_ENST00000441566.1_Missense_Mutation_p.N264I					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						AATTTGATTAATGCCATCAGA	0.318000													18	31					0	0	1	0	0
SMYD5	10322	broad.mit.edu	37	2	73446018	73446018	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:73446018C>T	ENST00000389501.4	+	2	171	c.126C>T	c.(124-126)atC>atT	p.I42I	SMYD5_ENST00000474652.1_3'UTR	NM_006062.2	NP_006053.2	Q6GMV2	SMYD5_HUMAN	SMYD family member 5	42							metal ion binding			NS(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	13						CACAGCTCATCCGGAAGGGGG	0.547000													15	8					0	0	1	0	0
BCL9L	283149	broad.mit.edu	37	11	118772714	118772714	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:118772714G>A	ENST00000334801.3	-	6	2702	c.1738C>T	c.(1738-1740)Ctg>Ttg	p.L580L	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	580					negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		GGCCCCCGCAGCTGCGCACCC	0.652000													9	15					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121059869	121059869	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:121059869G>A	ENST00000392793.1	+	22	6514	c.6243G>A	c.(6241-6243)agG>agA	p.R2081R	TECTA_ENST00000264037.2_Silent_p.R2081R			O75443	TECTA_HUMAN	tectorin alpha	2081					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GACCTATTAGGAGAAAAAGTA	0.428000													9	18					0	0	1	0	0
CUX1	1523	broad.mit.edu	37	7	101840442	101840442	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:101840442G>A	ENST00000360264.3	+	15	1804	c.1784G>A	c.(1783-1785)gGg>gAg	p.G595E	CUX1_ENST00000556210.1_Missense_Mutation_p.G482E|CUX1_ENST00000437600.4_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000550008.2_Missense_Mutation_p.G584E|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000549414.2_Missense_Mutation_p.G584E|CUX1_ENST00000292535.7_Missense_Mutation_p.G584E|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000546411.2_Missense_Mutation_p.G482E	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	584					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						CTGTCTCAAGGGTCCGTGAGC	0.502000													43	55					0	0	1	0	0
MUC15	143662	broad.mit.edu	37	11	26587134	26587134	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:26587134G>A	ENST00000436318.2	-	2	486	c.353C>T	c.(352-354)tCa>tTa	p.S118L	ANO3_ENST00000256737.3_Intron|ANO3_ENST00000537978.1_Intron|ANO3_ENST00000531568.1_Intron|MUC15_ENST00000527569.1_Missense_Mutation_p.S118L|ANO3_ENST00000525139.1_Intron|MUC15_ENST00000529533.1_Missense_Mutation_p.S118L|MUC15_ENST00000455601.2_Missense_Mutation_p.S91L|MUC15_ENST00000281268.8_Missense_Mutation_p.S118L			Q8N387	MUC15_HUMAN	mucin 15, cell surface associated	91						extracellular region|integral to membrane|plasma membrane		p.S91L(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25						CTCTGCTGATGAGTTACTGGA	0.433000													17	16					0	0	1	0	0
CCDC141	285025	broad.mit.edu	37	2	179732780	179732780	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:179732780G>A	ENST00000420890.2	-	16	2664	c.2547C>T	c.(2545-2547)gtC>gtT	p.V849V	CCDC141_ENST00000295723.5_Silent_p.V274V	NM_173648.3	NP_775919.3	Q6ZP82	CC141_HUMAN	coiled-coil domain containing 141	274	Ig-like.						protein binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(37)|ovary(8)|pancreas(2)|skin(4)|upper_aerodigestive_tract(1)	78			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.0531)|all cancers(119;0.147)			AGATGATGTCGACTCCTAAGG	0.498000													15	9					0	0	1	0	0
PRAF2	11230	broad.mit.edu	37	X	48931591	48931591	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:48931591G>A	ENST00000376390.4	-	1	139	c.56C>T	c.(55-57)tCg>tTg	p.S19L	WDR45_ENST00000376358.3_Intron|PRAF2_ENST00000376386.3_Missense_Mutation_p.S19L|WDR45_ENST00000553851.1_Intron	NM_007213.1	NP_009144.1			PRA1 domain family, member 2											endometrium(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	8						CAGACGCGCCGACCCCAGAAC	0.637000													9	15					0	0	1	0	0
B3GALNT2	148789	broad.mit.edu	37	1	235617519	235617519	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:235617519C>T	ENST00000366600.3	-	10	1488	c.1260G>A	c.(1258-1260)aaG>aaA	p.K420K		NM_152490.2	NP_689703.1	Q8NCR0	B3GL2_HUMAN	beta-1,3-N-acetylgalactosaminyltransferase 2	420					protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	18	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.0539)|Prostate(94;0.0353)	OV - Ovarian serous cystadenocarcinoma(106;0.000117)			TGACGATGTCCTTGGAGATCA	0.517000													18	28					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307998	140307998	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140307998C>T	ENST00000253807.2	+	1	1521	c.1521C>T	c.(1519-1521)atC>atT	p.I507I	PCDHA3_ENST00000522353.2_Intron|PCDHAC1_ENST00000409700.3_Silent_p.I507I|PCDHA1_ENST00000504120.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGGGGCCATCACTGCCAAAA	0.512000													32	42					0	0	1	0	0
SLC17A4	10050	broad.mit.edu	37	6	25769286	25769286	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:25769286G>A	ENST00000377905.4	+	3	284	c.165G>A	c.(163-165)atG>atA	p.M55I	SLC17A4_ENST00000439485.2_Missense_Mutation_p.M55I|SLC17A4_ENST00000397076.2_Start_Codon_SNP_p.M1I	NM_005495.2	NP_005486.1	Q9Y2C5	S17A4_HUMAN	solute carrier family 17, member 4	55					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			breast(4)|endometrium(1)|kidney(4)|large_intestine(3)|lung(21)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						CCCAACAAATGAACTTGAGCA	0.498000													55	8					0	0	1	0	0
OR56A3	390083	broad.mit.edu	37	11	5969447	5969447	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:5969447C>T	ENST00000329564.6	+	1	878	c.871C>T	c.(871-873)Ctt>Ttt	p.L291F		NM_001003443.2	NP_001003443.2	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A, member 3	291					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(27)|stomach(1)|upper_aerodigestive_tract(1)	41		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCCTGCAGCCCTTAACCCCAT	0.473000													34	45					0	0	1	0	0
NCR2	9436	broad.mit.edu	37	6	41303909	41303909	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:41303909G>A	ENST00000373083.4	+	2	359	c.137G>A	c.(136-138)gGc>gAc	p.G46D	NCR2_ENST00000373086.3_Missense_Mutation_p.G46D|NCR2_ENST00000373089.5_Missense_Mutation_p.G46D	NM_001199510.1	NP_001186439.1	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	46	Ig-like.				cellular defense response	integral to plasma membrane	transmembrane receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	14	Ovarian(28;0.0327)|Colorectal(47;0.196)					CCGCCCACGGGCAGTCTCTAC	0.557000													19	32					0	0	1	0	0
ITGA8	8516	broad.mit.edu	37	10	15686188	15686188	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:15686188C>T	ENST00000378076.3	-	13	1593	c.1240G>A	c.(1240-1242)Gat>Aat	p.D414N		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	414					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CCTCTTTGATCCTTGCCTGCA	0.398000													7	6					0	0	1	0	0
RPS13	6207	broad.mit.edu	37	11	17097072	17097072	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:17097072G>A	ENST00000525634.1	-	4	395	c.250C>T	c.(250-252)Ctt>Ttt	p.L84F	RPS13_ENST00000526895.1_5'UTR|RPS13_ENST00000228140.2_Missense_Mutation_p.L84F			P62277	RS13_HUMAN	ribosomal protein S13	84					endocrine pancreas development|negative regulation of RNA splicing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	mRNA binding|protein binding|structural constituent of ribosome			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)	5						TCTTCAGGAAGATCAGGAGCA	0.373000													12	14					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42361152	42361152	+	Silent	SNP	A	A	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:42361152A>G	ENST00000298119.4	+	4	3274	c.2085A>G	c.(2083-2085)gcA>gcG	p.A695A	LRFN5_ENST00000554120.1_Intron|LRFN5_ENST00000554171.1_Intron	NM_152447.3	NP_689660.2	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	695						integral to membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		CTAAAAGAGCACATATAAAGC	0.443000										HNSCC(30;0.082)			9	6					0	0	1	0	0
DEFB112	245915	broad.mit.edu	37	6	50016276	50016276	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:50016276C>T	ENST00000322246.4	-	1	88	c.89G>A	c.(88-90)cGa>cAa	p.R30Q		NM_001037498.1	NP_001032587.1	Q30KQ8	DB112_HUMAN	defensin, beta 112	30					defense response to bacterium	extracellular region				central_nervous_system(1)|large_intestine(3)|lung(12)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	19	Lung NSC(77;0.042)					TGTCCCATGTCGGGCCTTTTC	0.313000													16	31					0	0	1	0	0
HAPLN2	60484	broad.mit.edu	37	1	156593658	156593658	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:156593658C>T	ENST00000255039.1	+	4	552	c.145C>T	c.(145-147)Cgt>Tgt	p.R49C		NM_021817.2	NP_068589.1	Q9GZV7	HPLN2_HUMAN	hyaluronan and proteoglycan link protein 2	49	Ig-like V-type.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			NS(1)|endometrium(2)|large_intestine(1)|lung(1)|skin(1)|urinary_tract(1)	7	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCACTCTCATCGTGGGGCCAC	0.687000													5	8					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3160684	3160684	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:3160684G>A	ENST00000378398.3	+	3	503	c.421G>A	c.(421-423)Gaa>Aaa	p.E141K	PRDM16_ENST00000514189.1_Missense_Mutation_p.E141K|PRDM16_ENST00000511072.1_Missense_Mutation_p.E141K|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000442529.2_Missense_Mutation_p.E141K|PRDM16_ENST00000441472.2_Missense_Mutation_p.E141K|PRDM16_ENST00000378391.2_Missense_Mutation_p.E141K|PRDM16_ENST00000270722.5_Missense_Mutation_p.E141K			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	141	SET.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GTCGCCCCAGGAAGGCTGCAT	0.562000			T	EVI1	"""MDS, AML"""								15	20					0	0	1	0	0
LGALS9B	284194	broad.mit.edu	37	17	20358697	20358697	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:20358697G>A	ENST00000423676.3	-	5	522	c.459C>T	c.(457-459)gtC>gtT	p.V153V	LGALS9B_ENST00000324290.5_Silent_p.V153V			Q3B8N2	LEG9B_HUMAN	lectin, galactoside-binding, soluble, 9B	153							sugar binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)|upper_aerodigestive_tract(2)	10						GCTGAACGGGGACTGTGCGGG	0.587000													13	2					0	0	1	0	0
OR9A4	130075	broad.mit.edu	37	7	141618830	141618830	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:141618830A>T	ENST00000548136.1	+	1	214	c.155A>T	c.(154-156)aAa>aTa	p.K52I	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	52					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					TGTGTGGATAAACGTCTGCAG	0.448000													37	56					0	0	1	0	0
ANTXR1	84168	broad.mit.edu	37	2	69409720	69409720	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:69409720C>T	ENST00000303714.4	+	16	1603	c.1281C>T	c.(1279-1281)ttC>ttT	p.F427F		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	427					actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						AATATGAATTCCCTGAGCCGC	0.468000									Familial Infantile Hemangioma				20	6					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24809053	24809053	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:24809053G>A	ENST00000376451.2	+	6	1488	c.1226_splice	c.e6-1	p.E410_splice	KIAA1217_ENST00000458595.1_Splice_Site_p.E692_splice|KIAA1217_ENST00000396446.1_Splice_Site_p.E410_splice|KIAA1217_ENST00000430453.2_Intron|KIAA1217_ENST00000307544.6_Splice_Site_p.E410_splice|KIAA1217_ENST00000396445.1_Splice_Site_p.E410_splice|KIAA1217_ENST00000376462.1_Splice_Site_p.E647_splice|KIAA1217_ENST00000376454.3_Splice_Site_p.E727_splice|KIAA1217_ENST00000376452.3_Splice_Site_p.E692_splice			Q5T5P2	SKT_HUMAN	KIAA1217	727					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CTCCCGCAGCGAGTTGGAAGA	0.557000													35	17					0	0	1	0	0
STIM1	6786	broad.mit.edu	37	11	4107739	4107739	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:4107739C>T	ENST00000300737.4	+	11	2076	c.1507C>T	c.(1507-1509)Ctg>Ttg	p.L503L	STIM1_ENST00000533977.1_Silent_p.L330L|STIM1_ENST00000527651.1_Silent_p.L503L	NM_003156.3	NP_003147.2	Q13586	STIM1_HUMAN	stromal interaction molecule 1	503					activation of store-operated calcium channel activity|calcium ion transport|detection of calcium ion|platelet activation	integral to endoplasmic reticulum membrane|integral to plasma membrane|microtubule	calcium ion binding|microtubule plus-end binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|liver(1)|lung(14)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30		Breast(177;0.00159)|Medulloblastoma(188;0.00258)|all_neural(188;0.0233)		BRCA - Breast invasive adenocarcinoma(625;0.114)|LUSC - Lung squamous cell carcinoma(625;0.141)		TCGGCAGCGCCTGACGGAGCC	0.617000													10	19					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2210807	2210807	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:2210807C>T	ENST00000398665.3	+	14	1340	c.1304C>T	c.(1303-1305)gCc>gTc	p.A435V		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	435						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCACTGGATGCCCTGCACGCT	0.682000													8	31					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74004348	74004348	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:74004348G>A	ENST00000301607.3	-	22	5191	c.4938C>T	c.(4936-4938)ctC>ctT	p.L1646L	EVPL_ENST00000586740.1_Silent_p.L1668L	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1646	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						CCTTCTCGCGGAGGATGGCCG	0.677000													10	21					0	0	1	0	0
ZNF225	7768	broad.mit.edu	37	19	44636151	44636151	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:44636151G>A	ENST00000262894.6	+	5	1664	c.1384G>A	c.(1384-1386)Ggg>Agg	p.G462R	ZNF225_ENST00000592780.1_3'UTR|ZNF225_ENST00000590612.1_Missense_Mutation_p.G462R	NM_013362.2	NP_037494.2	Q9UK10	ZN225_HUMAN	zinc finger protein 225	462					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	16		Prostate(69;0.0352)|all_neural(266;0.202)				TAAGGAATGTGGGAAGAGCTT	0.433000													18	31					0	0	1	0	0
C12orf5	57103	broad.mit.edu	37	12	4461505	4461505	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:4461505C>T	ENST00000179259.4	+	6	528	c.461C>T	c.(460-462)tCc>tTc	p.S154F	C12orf5_ENST00000537251.1_3'UTR	NM_020375.2	NP_065108.1	Q9NQ88	TIGAR_HUMAN	chromosome 12 open reading frame 5	154						intracellular	fructose-2,6-bisphosphate 2-phosphatase activity			endometrium(1)|large_intestine(1)|lung(5)|skin(3)	10			all cancers(3;1.15e-07)|Colorectal(7;0.00165)|OV - Ovarian serous cystadenocarcinoma(31;0.00596)|COAD - Colon adenocarcinoma(12;0.0229)|GBM - Glioblastoma multiforme(3;0.0266)|STAD - Stomach adenocarcinoma(119;0.206)			GAACAGTTTTCCCAAGGATCT	0.358000													18	30					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58620522	58620522	+	Silent	SNP	G	G	A	rs145116433		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:58620522G>A	ENST00000317147.5	-	7	896	c.564C>T	c.(562-564)ctC>ctT	p.L188L	CNOT1_ENST00000569240.1_Silent_p.L188L|CNOT1_ENST00000441024.2_Silent_p.L188L	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	188					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GCCCAAAGAGGAGATGGGAGA	0.488000													94	172					0	0	1	0	0
TRPM2	7226	broad.mit.edu	37	21	45786738	45786738	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr21:45786738G>A	ENST00000397928.1	+	4	970	c.525G>A	c.(523-525)ggG>ggA	p.G175G	TRPM2_ENST00000300482.5_Silent_p.G175G|TRPM2_ENST00000397932.2_Silent_p.G175G|TRPM2_ENST00000300481.9_Silent_p.G175G	NM_003307.3	NP_003298.1	O94759	TRPM2_HUMAN	transient receptor potential cation channel, subfamily M, member 2	175						integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			breast(3)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(15)|lung(29)|ovary(3)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	76						CGGTGACCGGGGGGGCCAAGA	0.612000													23	6					0	0	1	0	0
TLR9	54106	broad.mit.edu	37	3	52256780	52256780	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:52256780G>A	ENST00000494383.1	-	5	2011	c.2012C>T	c.(2011-2013)cCt>cTt	p.P671L	TLR9_ENST00000597542.1_Silent_p.L542L|TLR9_ENST00000360658.2_Silent_p.L518L			Q9NR96	TLR9_HUMAN	toll-like receptor 9	0					defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			endometrium(4)|large_intestine(11)|lung(9)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	30				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	GTCAGCGGCAGGAACTGGGAG	0.622000													11	32					0	0	1	0	0
MDGA1	266727	broad.mit.edu	37	6	37618054	37618054	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:37618054C>T	ENST00000434837.2	-	8	2618	c.1440G>A	c.(1438-1440)aaG>aaA	p.K480K	MDGA1_ENST00000505425.1_Silent_p.K480K|MDGA1_ENST00000297153.7_Silent_p.K480K	NM_153487.3	NP_705691.1	Q8NFP4	MDGA1_HUMAN	MAM domain containing glycosylphosphatidylinositol anchor 1	480	Ig-like 5.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	38						GTGCAGCCTCCTTGTCCACGC	0.711000													8	12					0	0	1	0	0
FAM81A	145773	broad.mit.edu	37	15	59784512	59784512	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:59784512G>A	ENST00000288228.5	+	4	524	c.337G>A	c.(337-339)Gga>Aga	p.G113R		NM_152450.2	NP_689663.2	Q8TBF8	FA81A_HUMAN	family with sequence similarity 81, member A	113										endometrium(2)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10						CATTAGCTATGGAACTAATTC	0.483000													4	7					0	0	1	0	0
NLRP3	114548	broad.mit.edu	37	1	247588695	247588695	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:247588695C>T	ENST00000366497.2	+	4	2730	c.1950C>T	c.(1948-1950)ttC>ttT	p.F650F	NLRP3_ENST00000348069.2_Silent_p.F650F|NLRP3_ENST00000336119.3_Silent_p.F650F|NLRP3_ENST00000391828.3_Silent_p.F650F|NLRP3_ENST00000391827.2_Silent_p.F650F|NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000366496.2_Silent_p.F650F	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	650					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TGGACTATTTCCCCAAGATTG	0.493000													13	15					0	0	1	0	0
OR9A4	130075	broad.mit.edu	37	7	141619575	141619575	+	Silent	SNP	C	C	T	rs142578561	by1000genomes	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:141619575C>T	ENST00000548136.1	+	1	959	c.900C>T	c.(898-900)gcC>gcT	p.A300A	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	300					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					TCATAGAGGCCCTTCGGGATG	0.428000													14	31					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9071190	9071190	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:9071190G>A	ENST00000397910.4	-	3	16459	c.16256C>T	c.(16255-16257)tCc>tTc	p.S5419F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5421	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTGTTTGTGGAATGATGCAT	0.502000													116	205					0	0	1	0	0
ZNF470	388566	broad.mit.edu	37	19	57089265	57089265	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:57089265T>A	ENST00000330619.8	+	6	2154	c.1468T>A	c.(1468-1470)Ttc>Atc	p.F490I	ZNF470_ENST00000391709.3_Missense_Mutation_p.F490I|ZNF470_ENST00000601902.1_Intron	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	490					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		TGGGAAAGCTTTCCGGCAGAG	0.443000													19	28					0	0	1	0	0
SYN1	6853	broad.mit.edu	37	X	47464661	47464661	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:47464661G>A	ENST00000295987.7	-	4	769	c.645C>T	c.(643-645)tcC>tcT	p.S215S	SYN1_ENST00000340666.4_Silent_p.S215S	NM_006950.3	NP_008881.2	P17600	SYN1_HUMAN	synapsin I	215	C; actin-binding and synaptic-vesicle binding.					cell junction|Golgi apparatus	actin binding|ATP binding|ligase activity|transporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(6)|lung(6)|ovary(1)	21						CAGAATGCAAGGAGTTAACAC	0.537000													6	10					0	0	1	0	0
VCAM1	7412	broad.mit.edu	37	1	101186131	101186131	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:101186131C>T	ENST00000294728.2	+	2	265	c.164C>T	c.(163-165)cCa>cTa	p.P55L	VCAM1_ENST00000347652.2_Missense_Mutation_p.P55L|VCAM1_ENST00000370115.1_Missense_Mutation_p.P55L|VCAM1_ENST00000370119.4_Intron	NM_001078.3	NP_001069.1	P19320	VCAM1_HUMAN	vascular cell adhesion molecule 1	55	Ig-like C2-type 1.				heterophilic cell-cell adhesion|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|leukocyte tethering or rolling|membrane to membrane docking|positive regulation of T cell proliferation|regulation of immune response	alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex|apical part of cell|external side of plasma membrane|extracellular space|filopodium|integral to membrane|microvillus|podosome	cell adhesion molecule binding|integrin binding			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(27)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	56		all_epithelial(167;3.83e-06)|all_lung(203;0.000485)|Lung NSC(277;0.0011)		Epithelial(280;0.0227)|all cancers(265;0.0276)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)	Carvedilol(DB01136)	TGTGAGTCCCCATTTTTCTCT	0.473000													16	25					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141110552	141110552	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:141110552G>A	ENST00000389484.3	-	76	12591	c.11620C>T	c.(11620-11622)Caa>Taa	p.Q3874*		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	3874	EGF-like 9.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TTTCTTTCTTGAAAATTCTGG	0.313000										TSP Lung(27;0.18)			17	9					0	0	1	0	0
KCNQ2	3785	broad.mit.edu	37	20	62076129	62076129	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:62076129G>A	ENST00000354587.3	-	4	749	c.573C>T	c.(571-573)gtC>gtT	p.V191V	KCNQ2_ENST00000370224.1_Silent_p.V191V|KCNQ2_ENST00000370226.1_Silent_p.V191V|KCNQ2_ENST00000344425.5_Silent_p.V191V|KCNQ2_ENST00000359125.2_Silent_p.V191V|KCNQ2_ENST00000360480.3_Silent_p.V191V|KCNQ2_ENST00000370222.3_Silent_p.V191V|KCNQ2_ENST00000357249.2_Silent_p.V191V|KCNQ2_ENST00000430658.1_Silent_p.V191V|KCNQ2_ENST00000344462.3_Silent_p.V191V|KCNQ2_ENST00000359689.1_Silent_p.V191V|KCNQ2_ENST00000370221.1_Silent_p.V191V			O43526	KCNQ2_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 2	191					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			biliary_tract(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(4)|liver(1)|lung(30)|ovary(2)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	ATGTGGCAAAGACGTTGCCCT	0.662000													3	8					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120776803	120776803	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:120776803C>T	ENST00000263713.5	+	2	357	c.143C>T	c.(142-144)tCc>tTc	p.S48F	EPB41L5_ENST00000443902.2_Missense_Mutation_p.S48F|EPB41L5_ENST00000452780.1_Missense_Mutation_p.S48F|EPB41L5_ENST00000331393.4_Missense_Mutation_p.S48F|EPB41L5_ENST00000443124.1_Missense_Mutation_p.S48F	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	48	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						TGTCGGGTGTCCCTTCTGGAT	0.473000													58	26					0	0	1	0	0
KRTAP10-12	386685	broad.mit.edu	37	21	46117703	46117703	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr21:46117703C>T	ENST00000400365.3	+	1	617	c.587C>T	c.(586-588)tCc>tTc	p.S196F	TSPEAR_ENST00000323084.4_Intron	NM_198699.1	NP_941972.1	P60413	KR10C_HUMAN	keratin associated protein 10-12	196	19 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)|lung(8)	9						TCCTCCGTGTCCCTCCTCTGC	0.706000													59	29					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58723347	58723347	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:58723347G>A	ENST00000300079.5	+	7	899	c.849G>A	c.(847-849)atG>atA	p.M283I	RP11-142C4.6_ENST00000533954.1_RNA|GLYATL1_ENST00000317391.4_Missense_Mutation_p.M252I	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	252						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	TGCGATACATGAAATATCTGC	0.453000													9	17					0	0	1	0	0
IGHA2	3494	broad.mit.edu	37	14	106054648	106054648	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:106054648G>A	ENST00000390539.2	-	0	84																											AAGAAGCCCTGGACCAGGCAT	0.632000													17	40					0	0	1	0	0
KIAA1109	84162	broad.mit.edu	37	4	123161431	123161431	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:123161431C>T	ENST00000264501.4	+	29	4967	c.4594C>T	c.(4594-4596)Cgt>Tgt	p.R1532C	KIAA1109_ENST00000388738.3_Missense_Mutation_p.R1532C|KIAA1109_ENST00000455637.1_Missense_Mutation_p.R1532C			Q2LD37	K1109_HUMAN	KIAA1109	1532					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						CTCATTGCATCGTCCCCTTGA	0.383000													25	46					0	0	1	0	0
TTLL6	284076	broad.mit.edu	37	17	46868953	46868953	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:46868953G>A	ENST00000393382.3	-	9	1152	c.1011C>T	c.(1009-1011)acC>acT	p.T337T	TTLL6_ENST00000433608.2_Silent_p.T30T	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	289	TTL.					cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						ATGCACTGAAGGTGGAGAGCT	0.567000											OREG0024526	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	23					0	0	1	0	0
DAO	1610	broad.mit.edu	37	12	109294262	109294262	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:109294262G>A	ENST00000228476.3	+	11	1199	c.995G>A	c.(994-996)aGa>aAa	p.R332K	DAO_ENST00000551281.1_Missense_Mutation_p.R266K	NM_001917.4	NP_001908.3	P14920	OXDA_HUMAN	D-amino-acid oxidase	332					glyoxylate metabolic process	peroxisomal matrix	binding|D-amino-acid oxidase activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|prostate(2)|skin(1)	26						CTCTTTGGGAGAATCCTGGAA	0.562000													10	23					0	0	1	0	0
PRAMEF14	729528	broad.mit.edu	37	1	13669144	13669144	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:13669144C>T	ENST00000344998.3	-	4	1224	c.1042G>A	c.(1042-1044)Gac>Aac	p.D348N	PRAMEF14_ENST00000602491.1_5'UTR|PRAMEF14_ENST00000334600.6_Missense_Mutation_p.D396N			Q5SWL7	PRA14_HUMAN	PRAME family member 14	348										large_intestine(1)|skin(1)|upper_aerodigestive_tract(1)	3	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CACAACAGGTCCTTCAGGGCA	0.542000													41	72					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123556299	123556299	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:123556299G>A	ENST00000422452.2	-	24	4357	c.4294C>T	c.(4294-4296)Cta>Tta	p.L1432L	TENM1_ENST00000371130.3_Silent_p.L1425L|STAG2_ENST00000469481.1_3'UTR	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GCTGACTCTAGAGTGGAGTGA	0.537000													23	44					0	0	1	0	0
OR5D18	219438	broad.mit.edu	37	11	55587694	55587694	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:55587694C>T	ENST00000333976.4	+	1	609	c.589C>T	c.(589-591)Cag>Tag	p.Q197*		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				TTACATCAACCAGTGGCTGCT	0.398000													30	56					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143771320	143771320	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:143771320G>A	ENST00000408898.2	+	1	46	c.8G>A	c.(7-9)gGa>gAa	p.G3E		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	3					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					GAAATGGGGGGAAATCAGACT	0.448000													21	25					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600884	29600884	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:29600884G>T	ENST00000431530.3	+	1	2137	c.2079G>T	c.(2077-2079)aaG>aaT	p.K693N		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	683	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						ACGAAGAGAAGGCAGCAGGTG	0.587000													6	36					0.248553	0.248553	1	1	0
MEPE	56955	broad.mit.edu	37	4	88766616	88766616	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:88766616G>A	ENST00000497649.2	+	6	902	c.524G>A	c.(523-525)aGa>aAa	p.R175K	MEPE_ENST00000560249.1_Missense_Mutation_p.R86K|MEPE_ENST00000424957.3_Missense_Mutation_p.R199K|MEPE_ENST00000395102.4_Missense_Mutation_p.R230K|MEPE_ENST00000361056.3_Missense_Mutation_p.R199K|MEPE_ENST00000508016.1_3'UTR|MEPE_ENST00000540395.1_Missense_Mutation_p.R86K			Q9NQ76	MEPE_HUMAN	matrix extracellular phosphoglycoprotein	199					skeletal system development	proteinaceous extracellular matrix	extracellular matrix structural constituent|protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000432)		AAGCCTCAAAGAGATTCCCAA	0.368000													17	28					0	0	1	0	0
USP8	9101	broad.mit.edu	37	15	50782595	50782595	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:50782595C>T	ENST00000433963.1	+	15	2607	c.2107C>T	c.(2107-2109)Cct>Tct	p.P703S	USP8_ENST00000307179.4_Missense_Mutation_p.P703S|USP8_ENST00000396444.3_Missense_Mutation_p.P703S|USP8_ENST00000425032.3_Missense_Mutation_p.P597S	NM_001128611.1	NP_001122083.1	P40818	UBP8_HUMAN	ubiquitin specific peptidase 8	703					cell cycle|cell proliferation|endosome organization|protein K48-linked deubiquitination|protein K63-linked deubiquitination|ubiquitin-dependent protein catabolic process	cytosol|early endosome|extrinsic to plasma membrane|nucleus	cysteine-type endopeptidase activity|SH3 domain binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				all cancers(107;0.000225)|GBM - Glioblastoma multiforme(94;0.000771)		GCCACAGATTCCTGCTGAGCG	0.512000													36	46					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113403005	113403005	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:113403005C>T	ENST00000297405.5	-	36	6066	c.5822G>A	c.(5821-5823)gGa>gAa	p.G1941E	CSMD3_ENST00000352409.3_Missense_Mutation_p.G1871E|CSMD3_ENST00000343508.3_Missense_Mutation_p.G1901E|CSMD3_ENST00000455883.2_Missense_Mutation_p.G1837E	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1941	CUB 11.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AGTTAAAATTCCACCACAGGG	0.408000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			9	14					0	0	1	0	0
ADCYAP1	116	broad.mit.edu	37	18	905324	905324	+	Translation_Start_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:905324G>A	ENST00000579794.1	+	0	215				RP11-672L10.2_ENST00000581719.1_RNA|ADCYAP1_ENST00000450565.3_Intron|RP11-672L10.2_ENST00000577358.1_RNA|RP11-672L10.3_ENST00000582554.1_RNA	NM_001117.3	NP_001108.2	P18509	PACA_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary)						activation of adenylate cyclase activity|cell-cell signaling|female pregnancy|nerve growth factor receptor signaling pathway|regulation of G-protein coupled receptor protein signaling pathway	extracellular region|soluble fraction	neuropeptide hormone activity|peptide hormone receptor binding			endometrium(1)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)	12						GCTTTTTGGGGTTGGAGGGTG	0.647000													11	17					0	0	1	0	0
HLA-DMA	3108	broad.mit.edu	37	6	32917532	32917532	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:32917532C>T	ENST00000374843.4	-	3	593	c.508G>A	c.(508-510)Gga>Aga	p.G170R	HLA-DMA_ENST00000395305.3_Missense_Mutation_p.G75R|HLA-DMA_ENST00000395303.3_Missense_Mutation_p.G136R|HLA-DMA_ENST00000464392.1_5'UTR|XXbac-BPG181M17.5_ENST00000429234.1_Intron	NM_006120.3	NP_006111.2	Q31604	Q31604_HUMAN	major histocompatibility complex, class II, DM alpha	170						integral to membrane|MHC class II protein complex				kidney(1)|large_intestine(2)|lung(8)	11						GGCCCAAATCCTTCCACAGGG	0.483000													13	30					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12735228	12735228	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:12735228G>A	ENST00000380682.1	+	15	3156	c.2650G>A	c.(2650-2652)Gaa>Aaa	p.E884K		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	884					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						CGTGTCAGAAGAACAGCAGAC	0.507000													22	26					0	0	1	0	0
CMTR1	23070	broad.mit.edu	37	6	37446927	37446927	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:37446927C>T	ENST00000373451.4	+	23	2435	c.2271C>T	c.(2269-2271)ccC>ccT	p.P757P		NM_015050.2	NP_055865.1	Q8N1G2	MTR1_HUMAN		757	Interaction with POLR2A.|WW.				mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(6)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(2)	31						CATCAGAGCCCTGGACTATGG	0.512000													10	33					0	0	1	0	0
TMTC3	160418	broad.mit.edu	37	12	88554546	88554546	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:88554546C>T	ENST00000266712.6	+	6	935	c.715C>T	c.(715-717)Ctc>Ttc	p.L239F		NM_181783.3	NP_861448.2	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat containing 3	239						integral to membrane	binding			NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(5)|liver(1)|lung(12)|prostate(4)|skin(1)	31						ACTAGTAAAACTCATTGTCTT	0.378000													19	34					0	0	1	0	0
PTCHD1	139411	broad.mit.edu	37	X	23398035	23398035	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:23398035G>A	ENST00000379361.4	+	2	1539	c.679G>A	c.(679-681)Gag>Aag	p.E227K		NM_173495.2	NP_775766.2	Q96NR3	PTHD1_HUMAN	patched domain containing 1	227					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			NS(1)|breast(4)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|ovary(4)|skin(2)|urinary_tract(2)	42						CATGGTGGCTGAGAGGTGGGA	0.517000													70	112					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65253298	65253298	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:65253298G>A	ENST00000389722.3	-	15	3438	c.3385C>T	c.(3385-3387)Caa>Taa	p.Q1129*	SPTB_ENST00000556626.1_Nonsense_Mutation_p.Q1129*|SPTB_ENST00000389720.3_Nonsense_Mutation_p.Q1129*|SPTB_ENST00000542895.1_Nonsense_Mutation_p.Q1129*|SPTB_ENST00000389721.5_Nonsense_Mutation_p.Q1129*	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1129					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GTCTGGCCTTGGATCACTTTC	0.602000													23	24					0	0	1	0	0
MAN2B2	23324	broad.mit.edu	37	4	6599013	6599013	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:6599013C>T	ENST00000285599.3	+	8	1267	c.1231C>T	c.(1231-1233)Cgc>Tgc	p.R411C	MAN2B2_ENST00000504248.1_Missense_Mutation_p.R360C	NM_015274.1	NP_056089.1	Q9Y2E5	MA2B2_HUMAN	mannosidase, alpha, class 2B, member 2	411					mannose metabolic process	extracellular region	alpha-mannosidase activity|carbohydrate binding|zinc ion binding			breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(3)|lung(9)|ovary(4)|prostate(2)|skin(2)|urinary_tract(1)	30						CCAGCAGCTTCGCTGGGCCGT	0.632000													25	29					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435860	158435860	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:158435860C>T	ENST00000289451.2	+	1	589	c.509C>T	c.(508-510)tCc>tTc	p.S170F		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	170					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					CCCTTCCACTCCTCCAACCAG	0.537000													44	98					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42718182	42718182	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:42718182C>T	ENST00000230882.4	+	9	1094	c.904C>T	c.(904-906)Cca>Tca	p.P302S	GHR_ENST00000357703.3_Missense_Mutation_p.P280S|GHR_ENST00000537449.1_Missense_Mutation_p.P115S|GHR_ENST00000513625.1_3'UTR	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	302					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GCCCCCAGTTCCAGTTCCAAA	0.318000													7	28					0	0	1	0	0
ANK1	286	broad.mit.edu	37	8	41550196	41550196	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:41550196G>A	ENST00000396942.1	-	31	3911	c.3828C>T	c.(3826-3828)ttC>ttT	p.F1276F	ANK1_ENST00000379758.2_Silent_p.F1276F|ANK1_ENST00000396945.1_Silent_p.F1276F|ANK1_ENST00000347528.4_Silent_p.F1276F|ANK1_ENST00000289734.7_Silent_p.F1276F|ANK1_ENST00000265709.8_Silent_p.F1317F|ANK1_ENST00000352337.4_Silent_p.F1276F			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	1276					axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			CCACCTCCACGAAGTTCTCAT	0.577000													143	201					0	0	1	0	0
JPH1	56704	broad.mit.edu	37	8	75227656	75227656	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:75227656G>A	ENST00000342232.4	-	2	619	c.579C>T	c.(577-579)ttC>ttT	p.F193F		NM_020647.2	NP_065698.1	Q9HDC5	JPH1_HUMAN	junctophilin 1	193					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional membrane complex|junctional sarcoplasmic reticulum membrane|plasma membrane				endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	24	Breast(64;0.00576)		BRCA - Breast invasive adenocarcinoma(89;0.0499)|Epithelial(68;0.0728)|all cancers(69;0.176)			AGTTGAGCACGAAACCGCCGC	0.677000													11	29					0	0	1	0	0
ARHGAP4	393	broad.mit.edu	37	X	153186111	153186111	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:153186111G>A	ENST00000370028.3	-	5	707	c.650C>T	c.(649-651)tCc>tTc	p.S217F	ARHGAP4_ENST00000350060.5_Missense_Mutation_p.S217F|ARHGAP4_ENST00000370016.1_Missense_Mutation_p.S196F|ARHGAP4_ENST00000393721.1_Intron|ARHGAP4_ENST00000537206.1_Missense_Mutation_p.S194F	NM_001164741.1	NP_001158213.1	P98171	RHG04_HUMAN	Rho GTPase activating protein 4	217					apoptosis|cytoskeleton organization|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|Rho protein signal transduction	cytosol|focal adhesion|nucleus	Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			central_nervous_system(2)|endometrium(2)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CTTCTTGAGGGAGCTCTTGCG	0.682000													15	17					0	0	1	0	0
AGT	183	broad.mit.edu	37	1	230846563	230846563	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:230846563G>A	ENST00000366667.4	-	2	248	c.34C>T	c.(34-36)Cct>Tct	p.P12S	RP11-99J16__A.2_ENST00000412344.1_RNA	NM_000029.3	NP_000020.1	P01019	ANGT_HUMAN	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	12					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding			endometrium(5)|kidney(1)|large_intestine(6)|lung(7)|pancreas(1)|prostate(5)	25	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	ACACCGGCAGGAGCCATCTCA	0.562000													14	19					0	0	1	0	0
SUN2	25777	broad.mit.edu	37	22	39147369	39147369	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:39147369C>T	ENST00000405510.1	-	4	490	c.132G>A	c.(130-132)aaG>aaA	p.K44K	SUN2_ENST00000405018.1_Silent_p.K44K|SUN2_ENST00000406622.1_Silent_p.K44K|SUN2_ENST00000216064.4_Silent_p.K44K|SUN2_ENST00000411587.2_Silent_p.K79K	NM_001199580.1	NP_001186509.1	Q9UH99	SUN2_HUMAN	Sad1 and UNC84 domain containing 2	44	LMNA-binding (By similarity).|Ser-rich.				centrosome localization|cytoskeletal anchoring at nuclear membrane|mitotic spindle organization|nuclear envelope organization|nuclear matrix anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	endosome membrane|integral to membrane|nuclear inner membrane|SUN-KASH complex	lamin binding|microtubule binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|skin(2)|stomach(1)	15						TGGATTTCCTCTTCAAGGTCC	0.612000													24	20					0	0	1	0	0
SF1	7536	broad.mit.edu	37	11	64533497	64533497	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:64533497G>A	ENST00000377390.3	-	13	2050	c.1713C>T	c.(1711-1713)ccC>ccT	p.P571P	SF1_ENST00000227503.9_Intron|SF1_ENST00000377387.1_Intron|SF1_ENST00000377394.3_Intron|SF1_ENST00000433274.2_Silent_p.P545P|SF1_ENST00000422298.2_Intron|SF1_ENST00000334944.5_Silent_p.P571P	NM_004630.3	NP_004621.2	Q15637	SF01_HUMAN	splicing factor 1	571	Pro-rich.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	31						GCTGGACCCCGGGGGGCAGGG	0.731000													11	15					0	0	1	0	0
HIVEP1	3096	broad.mit.edu	37	6	12122042	12122042	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:12122042G>A	ENST00000379388.2	+	4	2346	c.2014G>A	c.(2014-2016)Gat>Aat	p.D672N		NM_002114.2	NP_002105.2	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer binding protein 1	672					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(11)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	90	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AGGAAGTACGGATTCTGGTTA	0.507000													9	20					0	0	1	0	0
BRMS1L	84312	broad.mit.edu	37	14	36300691	36300691	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:36300691C>T	ENST00000216807.7	+	2	417	c.218C>T	c.(217-219)aCc>aTc	p.T73I	BRMS1L_ENST00000543183.1_Missense_Mutation_p.T25I	NM_032352.3	NP_115728.2	Q5PSV4	BRM1L_HUMAN	breast cancer metastasis-suppressor 1-like	73					regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(1)|lung(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9	Breast(36;0.137)|Hepatocellular(127;0.158)		Lung(8;1.7e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.00467)|all cancers(34;0.0157)|BRCA - Breast invasive adenocarcinoma(188;0.158)	GBM - Glioblastoma multiforme(112;0.0333)		AAACAGTTTACCGATCTCAAA	0.348000													8	11					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71634912	71634912	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:71634912G>A	ENST00000356340.3	+	4	964	c.428G>A	c.(427-429)gGa>gAa	p.G143E	COL13A1_ENST00000398966.3_Missense_Mutation_p.G143E|COL13A1_ENST00000398972.3_Missense_Mutation_p.G143E|COL13A1_ENST00000354547.3_Missense_Mutation_p.G143E|COL13A1_ENST00000398974.3_Intron|COL13A1_ENST00000520133.1_Intron|COL13A1_ENST00000398969.3_Intron|COL13A1_ENST00000398964.3_Intron|COL13A1_ENST00000517713.1_Missense_Mutation_p.G143E|COL13A1_ENST00000357811.3_Missense_Mutation_p.G143E|COL13A1_ENST00000520267.1_Intron|COL13A1_ENST00000398973.3_Missense_Mutation_p.G143E|COL13A1_ENST00000398971.3_Missense_Mutation_p.G143E|COL13A1_ENST00000398968.3_Missense_Mutation_p.G143E|COL13A1_ENST00000398978.3_Missense_Mutation_p.G143E|COL13A1_ENST00000522165.1_Missense_Mutation_p.G143E			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	143	Triple-helical region 1 (COL1).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	GGGATGCCTGGACGTGTGGTG	0.547000													13	3					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73151406	73151406	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:73151406C>T	ENST00000377110.2	-	25	4830	c.4587G>A	c.(4585-4587)agG>agA	p.R1529R	TRPM3_ENST00000377105.1_Silent_p.R1388R|TRPM3_ENST00000377106.1_Silent_p.R1401R|TRPM3_ENST00000408909.2_Silent_p.R1388R|TRPM3_ENST00000377111.2_Intron|TRPM3_ENST00000360823.2_Silent_p.R1391R|TRPM3_ENST00000396292.4_Silent_p.R1401R|TRPM3_ENST00000396285.1_Silent_p.R1388R|TRPM3_ENST00000357533.2_Silent_p.R1533R|TRPM3_ENST00000396280.5_Silent_p.R1378R|TRPM3_ENST00000358082.3_Silent_p.R1391R|TRPM3_ENST00000423814.3_Silent_p.R1556R	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	1554						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						CATAATAGCTCCTTGAGGGGG	0.448000													31	13					0	0	1	0	0
HSD3B7	80270	broad.mit.edu	37	16	30997973	30997973	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:30997973C>T	ENST00000262520.6	+	5	769	c.479C>T	c.(478-480)cCt>cTt	p.P160L	HSD3B7_ENST00000353250.5_Missense_Mutation_p.P160L|HSD3B7_ENST00000297679.5_Missense_Mutation_p.P160L	NM_001142777.1	NP_001136249.1	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	160					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						CACCCCTATCCTTGCAGCAAG	0.607000													24	39					0	0	1	0	0
NT5DC2	64943	broad.mit.edu	37	3	52562556	52562556	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:52562556C>T	ENST00000307076.4	-	5	838		c.e5-1		NT5DC2_ENST00000459839.1_Splice_Site|NT5DC2_ENST00000422318.2_Splice_Site|NT5DC2_ENST00000307092.4_Splice_Site	NM_022908.2	NP_075059.1	Q9H857	NT5D2_HUMAN	5'-nucleotidase domain containing 2								hydrolase activity|metal ion binding			endometrium(1)|lung(3)|prostate(1)|stomach(1)	6				BRCA - Breast invasive adenocarcinoma(193;1.7e-05)|Kidney(197;0.00177)|KIRC - Kidney renal clear cell carcinoma(197;0.002)|OV - Ovarian serous cystadenocarcinoma(275;0.0476)		CTGGAGGCCCCTGAGCAGGCC	0.597000													15	23					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20795139	20795139	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:20795139G>A	ENST00000404938.2	+	28	4318	c.3666G>A	c.(3664-3666)ttG>ttA	p.L1222L	ABCB5_ENST00000258738.6_Silent_p.L777L	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	777					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						ACGCAGATTTGATAGTGGTTC	0.453000													11	18					0	0	1	0	0
ZNF285	26974	broad.mit.edu	37	19	44890669	44890669	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:44890669G>A	ENST00000330997.4	-	4	1802	c.1738C>T	c.(1738-1740)Cat>Tat	p.H580Y	ZNF285_ENST00000591679.1_Missense_Mutation_p.H587Y|CTC-512J12.6_ENST00000588212.1_Intron|ZNF285_ENST00000544719.2_Missense_Mutation_p.H580Y	NM_152354.3	NP_689567.3			zinc finger protein 285											breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|prostate(5)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	44						AGTCTTTGATGAGTCAGAAGG	0.413000													16	41					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160738735	160738735	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:160738735C>T	ENST00000263636.4	-	7	1173	c.1146G>A	c.(1144-1146)tgG>tgA	p.W382*	LY75_ENST00000553424.1_Nonsense_Mutation_p.W382*|LY75-CD302_ENST00000505052.1_Nonsense_Mutation_p.W382*|LY75-CD302_ENST00000504764.1_Nonsense_Mutation_p.W382*|LY75_ENST00000554112.1_Nonsense_Mutation_p.W382*	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		GTGCCTTATCCCAGGAATTAC	0.453000													28	14					0	0	1	0	0
CERS6	253782	broad.mit.edu	37	2	169571592	169571592	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:169571592G>A	ENST00000305747.6	+	7	1278	c.691G>A	c.(691-693)Gga>Aga	p.G231R	CERS6_ENST00000392687.4_Missense_Mutation_p.G231R	NM_203463.2	NP_982288.1	Q6ZMG9	CERS6_HUMAN	ceramide synthase 6	231	TLC.					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										GGCCCGAGTAGGAACGCTGGT	0.378000													32	12					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9063547	9063547	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:9063547T>C	ENST00000397910.4	-	3	24102	c.23899A>G	c.(23899-23901)Aaa>Gaa	p.K7967E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7969	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTCTAGTTTTTTCCAGAAGG	0.468000													13	19					0	0	1	0	0
ITGB4	3691	broad.mit.edu	37	17	73738533	73738533	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:73738533G>A	ENST00000200181.3	+	24	2932	c.2745G>A	c.(2743-2745)aaG>aaA	p.K915K	ITGB4_ENST00000584558.1_3'UTR|ITGB4_ENST00000450894.3_Silent_p.K915K|ITGB4_ENST00000449880.2_Silent_p.K915K|ITGB4_ENST00000579662.1_Silent_p.K915K|ITGB4_ENST00000339591.3_Silent_p.K915K	NM_000213.3	NP_000204.3	P16144	ITB4_HUMAN	integrin, beta 4	915					cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(1)|lung(25)|skin(1)|urinary_tract(1)	43	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACGACCTCAAGGTGGCCCCCG	0.662000													10	11					0	0	1	0	0
EPHA4	2043	broad.mit.edu	37	2	222301232	222301232	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:222301232G>A	ENST00000281821.2	-	13	2274	c.2233C>T	c.(2233-2235)Cgt>Tgt	p.R745C	EPHA4_ENST00000392071.4_Missense_Mutation_p.R694C|EPHA4_ENST00000409938.1_Missense_Mutation_p.R745C|EPHA4_ENST00000409854.1_Missense_Mutation_p.R745C	NM_004438.3	NP_004429.1	P54764	EPHA4_HUMAN	EPH receptor A4	745	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(21)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		GCCAGATCACGATGCACATAG	0.493000													25	11					0	0	1	0	0
GPR133	283383	broad.mit.edu	37	12	131569139	131569139	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:131569139C>T	ENST00000261654.5	+	15	2161	c.1602C>T	c.(1600-1602)ctC>ctT	p.L534L	GPR133_ENST00000376682.4_Silent_p.L220L|GPR133_ENST00000543617.1_Silent_p.L53L|GPR133_ENST00000535015.1_Silent_p.L566L	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	534	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GAGGAAACCTCACCTACTCCG	0.622000													24	38					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70896023	70896023	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:70896023C>T	ENST00000393567.2	-	69	11855	c.11705G>A	c.(11704-11706)gGg>gAg	p.G3902E		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	3902										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CTGAATCTTCCCCACCGGCAC	0.547000													8	12					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57642615	57642615	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:57642615G>A	ENST00000254181.4	+	4	3026	c.2572G>A	c.(2572-2574)Gat>Aat	p.D858N	USP29_ENST00000598197.1_Missense_Mutation_p.D858N	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	858					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CACATACAACGATCTATGTGT	0.453000													7	15					0	0	1	0	0
BLM	641	broad.mit.edu	37	15	91295039	91295039	+	Silent	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:91295039T>C	ENST00000355112.3	+	4	940	c.822T>C	c.(820-822)aaT>aaC	p.N274N	BLM_ENST00000560509.1_Silent_p.N274N	NM_000057.2	NP_000048.1	P54132	BLM_HUMAN	Bloom syndrome, RecQ helicase-like	274					double-strand break repair via homologous recombination|G2 phase of mitotic cell cycle|G2/M transition DNA damage checkpoint|negative regulation of cell division|positive regulation of transcription, DNA-dependent|protein oligomerization|regulation of cyclin-dependent protein kinase activity|replication fork processing|replication fork protection|response to X-ray	cytoplasm|lateral element|nuclear matrix|nucleolus|PML body	ATP binding|bubble DNA binding|DNA strand annealing activity|four-way junction helicase activity|G-quadruplex DNA binding|p53 binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(11)|liver(4)|lung(9)|ovary(6)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	Lung NSC(78;0.0875)|all_lung(78;0.109)		Lung(145;0.189)			AGAAGAAGAATTTGGAAGAAG	0.333000			"""Mis, N, F"""			"""leukemia, lymphoma, skin squamous cell , other cancers"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Bloom syndrome				6	23					0	0	1	0	0
ACE	1636	broad.mit.edu	37	17	61568606	61568606	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:61568606G>A	ENST00000577647.1	+	8	1099	c.1054G>A	c.(1054-1056)Gat>Aat	p.D352N	ACE_ENST00000490216.2_Missense_Mutation_p.D352N|ACE_ENST00000413513.3_Missense_Mutation_p.D352N|ACE_ENST00000290863.6_Missense_Mutation_p.D352N|ACE_ENST00000421982.2_Missense_Mutation_p.D172N|ACE_ENST00000290866.4_Missense_Mutation_p.D926N|ACE_ENST00000428043.1_Missense_Mutation_p.D926N			P12821	ACE_HUMAN	angiotensin I converting enzyme	926	Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GGAGGCTGATGATTTCTTCAC	0.632000													29	26					0	0	1	0	0
HAO1	54363	broad.mit.edu	37	20	7915258	7915258	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:7915258G>A	ENST00000378789.3	-	2	213	c.162C>T	c.(160-162)ctC>ctT	p.L54L		NM_017545.2	NP_060015.1	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase (glycolate oxidase) 1	54	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(19)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						CAACATTCCGGAGCATCCTTG	0.403000													13	21					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142625877	142625877	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:142625877C>T	ENST00000265310.1	-	6	1019	c.671G>A	c.(670-672)gGa>gAa	p.G224E	TRPV5_ENST00000442623.1_Missense_Mutation_p.G224E	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	224					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					GTCCCCATGTCCATCGTAGGA	0.567000													20	31					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28422225	28422225	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:28422225G>A	ENST00000261609.7	-	61	9411	c.9303C>T	c.(9301-9303)atC>atT	p.I3101I		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	3101					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CGATATCCCGGATACGCTTGG	0.567000													9	30					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32631485	32631485	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:32631485G>A	ENST00000242310.4	-	1	4182	c.4093C>T	c.(4093-4095)Cct>Tct	p.P1365S		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1365					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TGCTGTTTAGGAAACTTGAGA	0.438000													49	55					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50250648	50250648	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:50250648C>T	ENST00000246801.3	-	5	743	c.661G>A	c.(661-663)Gag>Aag	p.E221K		NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	221							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		GCCCTTACCTCCAGCAGGGCA	0.557000													4	33					0	0	1	0	0
PRR19	284338	broad.mit.edu	37	19	42814736	42814736	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:42814736C>T	ENST00000499536.2	+	2	1726	c.915C>T	c.(913-915)ctC>ctT	p.L305L	PRR19_ENST00000341747.3_Silent_p.L305L|PRR19_ENST00000598490.1_3'UTR			A6NJB7	PRR19_HUMAN	proline rich 19	305	Pro-rich.									NS(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	10		Prostate(69;0.00682)				GGGTTGGCCTCCCTCAGCCCC	0.657000													59	75					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237880599	237880599	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:237880599C>T	ENST00000366574.2	+	72	10742	c.10425C>T	c.(10423-10425)ccC>ccT	p.P3475P	RYR2_ENST00000542537.1_Silent_p.P3459P|RYR2_ENST00000360064.6_Silent_p.P3473P	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3475					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GGTTACTGCCCATTGGGTTGA	0.493000													4	16					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14513675	14513675	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:14513675T>C	ENST00000358970.5	-	10	1518	c.1519A>G	c.(1519-1521)Aaa>Gaa	p.K507E		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	507								p.K507E(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						GAATTCATTTTCTTTTCAGCC	0.284000													3	47					0	0	1	0	0
ZNF20	7568	broad.mit.edu	37	19	12246706	12246706	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:12246706G>A	ENST00000334213.5	-	2	241	c.17C>T	c.(16-18)tCa>tTa	p.S6L	ZNF20_ENST00000600335.1_Missense_Mutation_p.S3L|ZNF20_ENST00000485451.1_5'UTR|ZNF625-ZNF20_ENST00000430024.1_3'UTR	NM_001203250.1|NM_021143.3	NP_001190179.1|NP_066966.2	P17024	ZNF20_HUMAN	zinc finger protein 20	6					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|lung(6)	8						AAAGGCCACTGAATCCTGAAA	0.468000													8	20					0	0	1	0	0
RHOB	388	broad.mit.edu	37	2	20647244	20647244	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:20647244G>A	ENST00000272233.4	+	1	410	c.18G>A	c.(16-18)aaG>aaA	p.K6K		NM_004040.2	NP_004031.1	P62745	RHOB_HUMAN	ras homolog family member B	6					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|kidney(1)|lung(2)|ovary(1)|urinary_tract(2)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		CCATCCGCAAGAAGCTGGTGG	0.706000													17	7					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13776692	13776692	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:13776692G>A	ENST00000265104.4	-	55	9333	c.9229C>T	c.(9229-9231)Cgg>Tgg	p.R3077W		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3077	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TGTCGGACCCGACTCATGAAG	0.463000									Kartagener syndrome				18	36					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43572121	43572121	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:43572121C>T	ENST00000452443.2	-	10	1384	c.1380G>A	c.(1378-1380)atG>atA	p.M460I		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	460					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity	p.M460I(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	GAGAAGCCTTCATGAAGACAG	0.587000													27	46					0	0	1	0	0
SNX29P2	440352	broad.mit.edu	37	16	29376178	29376178	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:29376178G>A	ENST00000398878.3	+	0	1606				SNX29P2_ENST00000507381.1_RNA																							GTCCGCCTTTGAAAGCCCCTT	0.507000													13	21					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8384476	8384476	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:8384476G>A	ENST00000471889.1	+	2	472	c.87G>A	c.(85-87)acG>acA	p.T29T	SLC45A1_ENST00000377479.2_Silent_p.T63T|SLC45A1_ENST00000289877.8_Silent_p.T29T			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	29					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CCCAGGTCACGGGCTACTCGG	0.667000													37	49					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60419818	60419818	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:60419818C>T	ENST00000360469.5	+	5	759	c.671C>T	c.(670-672)tCc>tTc	p.S224F	CDH4_ENST00000543233.1_Missense_Mutation_p.S150F	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	224	Cadherin 1.				adherens junction organization|cell junction assembly		calcium ion binding	p.S224C(1)		NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			AGCATTGACTCCATGTCCGGC	0.617000													29	21					0	0	1	0	0
CIDEA	1149	broad.mit.edu	37	18	12277250	12277250	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:12277250G>A	ENST00000320477.9	+	5	706	c.641G>A	c.(640-642)gGc>gAc	p.G214D	CIDEA_ENST00000521296.1_3'UTR	NM_001279.3	NP_001270.1	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a	214					DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)	13						CAAGCCAAGGGCAGGTTCACG	0.542000													19	24					0	0	1	0	0
RSPH1	89765	broad.mit.edu	37	21	43896020	43896020	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr21:43896020C>T	ENST00000291536.3	-	8	1032	c.865G>A	c.(865-867)Gac>Aac	p.D289N	RSPH1_ENST00000398352.3_Missense_Mutation_p.D251N	NM_080860.2	NP_543136.1	Q8WYR4	RSPH1_HUMAN	radial spoke head 1 homolog (Chlamydomonas)	289					meiosis	cytosol|nucleus				large_intestine(7)|lung(2)|ovary(1)|prostate(1)|stomach(1)	12						TCATCCATGTCATAGCGGAAC	0.622000													10	13					0	0	1	0	0
LRRC30	339291	broad.mit.edu	37	18	7231751	7231751	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:7231751C>T	ENST00000383467.2	+	1	629	c.615C>T	c.(613-615)atC>atT	p.I205I		NM_001105581.1	NP_001099051.1	A6NM36	LRC30_HUMAN	leucine rich repeat containing 30	205										central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(1)|lung(13)|ovary(1)|prostate(1)|skin(3)	31						CTGAGAGCATCCAGCACCTGG	0.562000													14	32					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55541857	55541857	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:55541857C>T	ENST00000220676.1	+	4	5563	c.5415C>T	c.(5413-5415)ctC>ctT	p.L1805L		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1805					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CTTCAGAACTCGAGGAACTGA	0.443000													6	6					0	0	1	0	0
ADH4	127	broad.mit.edu	37	4	100062756	100062756	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:100062756G>A	ENST00000508393.1	-	4	420	c.255C>T	c.(253-255)atC>atT	p.I85I	ADH4_ENST00000423445.1_Silent_p.I85I|ADH4_ENST00000265512.7_Silent_p.I66I|RP11-696N14.1_ENST00000500358.2_RNA|ADH4_ENST00000505590.1_Silent_p.I85I			P08319	ADH4_HUMAN	alcohol dehydrogenase 4 (class II), pi polypeptide	66					alcohol catabolic process|cellular aldehyde metabolic process|ethanol oxidation|quinone cofactor metabolic process|retinol metabolic process|xenobiotic metabolic process	cytosol|microtubule cytoskeleton	alcohol dehydrogenase activity, zinc-dependent|all-trans retinal binding|benzaldehyde dehydrogenase activity|NAD binding|NADPH:quinone reductase activity|retinol binding|retinol dehydrogenase activity|zinc ion binding			NS(1)|cervix(1)|large_intestine(2)|liver(2)|lung(8)|prostate(2)|skin(2)	18				OV - Ovarian serous cystadenocarcinoma(123;4.48e-08)	NADH(DB00157)	CATGGCCAACGATCACTGGGA	0.428000													15	14					0	0	1	0	0
GOLGA2P9	440518	broad.mit.edu	37	19	22784242	22784242	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:22784242G>A	ENST00000600260.1	+	0	676					NR_033899.1																						GGAAGGTACGGGAGATCACTC	0.597000													9	5					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201009205	201009205	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:201009205C>T	ENST00000362061.3	-	44	5602	c.5376G>A	c.(5374-5376)ctG>ctA	p.L1792L	CACNA1S_ENST00000367338.3_Silent_p.L1773L|RP11-168O16.2_ENST00000415359.1_RNA	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1792					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CCCCTCGAACCAGAGCCTGCA	0.622000													17	25					0	0	1	0	0
SIGLECL1	284369	broad.mit.edu	37	19	51768743	51768743	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:51768743G>A	ENST00000316401.7	+	3	525	c.144G>A	c.(142-144)gtG>gtA	p.V48V	SIGLECL1_ENST00000597824.1_Intron|CTD-3187F8.2_ENST00000597569.1_RNA|SIGLECL1_ENST00000593968.1_Intron	NM_173635.1	NP_775906.1			SIGLEC family like 1																		CCGTGGGTGTGGATGGCATGG	0.577000													15	17					0	0	1	0	0
CRYBB1	1414	broad.mit.edu	37	22	27012113	27012113	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:27012113C>T	ENST00000215939.2	-	2	301	c.171G>A	c.(169-171)ggG>ggA	p.G57G		NM_001887.3	NP_001878.1	P53674	CRBB1_HUMAN	crystallin, beta B1	57	N-terminal arm.				visual perception		structural constituent of eye lens			breast(1)|endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|prostate(3)|skin(2)|urinary_tract(4)	31						CCCTGTAGTTCCCAGGAGGCA	0.617000													17	23					0	0	1	0	0
NAA10	8260	broad.mit.edu	37	X	153197787	153197787	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:153197787G>A	ENST00000464845.1	-	5	641	c.323C>T	c.(322-324)tCc>tTc	p.S108F	NAA10_ENST00000370009.1_Missense_Mutation_p.S108F|NAA10_ENST00000370015.4_Missense_Mutation_p.S108F|NAA10_ENST00000393712.3_Missense_Mutation_p.S108F|NAA10_ENST00000393710.3_5'UTR	NM_001256120.1|NM_003491.3	NP_001243049.1|NP_003482.1	P41227	NAA10_HUMAN	N(alpha)-acetyltransferase 10, NatA catalytic subunit	108	N-acetyltransferase.				DNA packaging|internal protein amino acid acetylation|N-terminal protein amino acid acetylation	cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(3)|ovary(1)|prostate(1)	10						GACATGCAGGGAGACATATTT	0.582000													12	16					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233225830	233225830	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:233225830C>T	ENST00000258229.8	-	23	4287	c.4053G>A	c.(4051-4053)gtG>gtA	p.V1351V		NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1351						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				CCCAGAATTTCACTGGCCTGA	0.423000													8	21					0	0	1	0	0
NGLY1	55768	broad.mit.edu	37	3	25781175	25781175	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:25781175C>A	ENST00000428257.1	-	5	881	c.774G>T	c.(772-774)agG>agT	p.R258S	NGLY1_ENST00000422724.2_Intron|NGLY1_ENST00000417874.2_Missense_Mutation_p.R216S|NGLY1_ENST00000280700.5_Missense_Mutation_p.R258S|NGLY1_ENST00000396649.3_Missense_Mutation_p.R258S	NM_001145293.1	NP_001138765.1	Q96IV0	NGLY1_HUMAN	N-glycanase 1	258					glycoprotein catabolic process	cytoplasm	metal ion binding|peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity|protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(2)|skin(1)	18						TATCTCTAGACCTAGTCTGTC	0.433000													28	49					0.000227799	0.000228475	1	1	0
SCML2	10389	broad.mit.edu	37	X	18323267	18323267	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:18323267G>A	ENST00000251900.4	-	7	714	c.555C>T	c.(553-555)aaC>aaT	p.N185N		NM_006089.2	NP_006080.1	Q9UQR0	SCML2_HUMAN	sex comb on midleg-like 2 (Drosophila)	185					anatomical structure morphogenesis	PcG protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	36	Hepatocellular(33;0.183)					TGAGATACGGGTTCTTTTTGT	0.383000													58	77					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9076306	9076306	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:9076306G>A	ENST00000397910.4	-	3	11343	c.11140C>T	c.(11140-11142)Cat>Tat	p.H3714Y		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3715	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTACTAGCATGATCTGTAGAA	0.458000													26	37					0	0	1	0	0
ASPG	374569	broad.mit.edu	37	14	104570642	104570642	+	Splice_Site	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:104570642T>C	ENST00000551177.1	+	8	847	c.753_splice	c.e8-1	p.V252_splice	ASPG_ENST00000455920.2_Splice_Site_p.V252_splice|ASPG_ENST00000546892.2_Splice_Site_p.V252_splice	NM_001080464.2	NP_001073933.2	Q86U10	LPP60_HUMAN	asparaginase homolog (S. cerevisiae)	252	Asparaginase.				lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	11						GCCCCACAGGTTCGGGCCTTC	0.672000													4	15					0	0	1	0	0
OR8S1	341568	broad.mit.edu	37	12	48919741	48919741	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:48919741G>A	ENST00000310194.1	+	1	327	c.327G>A	c.(325-327)ggG>ggA	p.G109G	OR8S1_ENST00000551654.1_Intron	NM_001005203.2	NP_001005203.2	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S, member 1	109					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|skin(4)	22						TCACTGCAGGGACTGAAGCCT	0.522000													14	31					0	0	1	0	0
VPS39	23339	broad.mit.edu	37	15	42455830	42455830	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:42455830G>A	ENST00000318006.5	-	20	2285	c.2123C>T	c.(2122-2124)gCt>gTt	p.A708V	VPS39_ENST00000348544.4_Missense_Mutation_p.A719V	NM_015289.2	NP_056104.2	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39 homolog (S. cerevisiae)	719					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			breast(2)|kidney(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		TTACTCCTCAGCCATCCTTGT	0.493000													3	6					0	0	1	0	0
PCDHGA7	56108	broad.mit.edu	37	5	140763701	140763701	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140763701G>A	ENST00000518325.1	+	1	1235	c.1235G>A	c.(1234-1236)cGg>cAg	p.R412Q	PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACTTGGACCGGGAAACACTC	0.413000													8	7					0	0	1	0	0
TRBV7-3	28595	broad.mit.edu	37	7	142247204	142247204	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:142247204G>A	ENST00000390361.3	-	0	301																											TGACTGCAAAGAACCGATCGT	0.567000													12	39					0	0	1	0	0
PDX1	3651	broad.mit.edu	37	13	28498678	28498678	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:28498678C>T	ENST00000381033.4	+	2	811	c.692C>T	c.(691-693)tCc>tTc	p.S231F		NM_000209.3	NP_000200.1	P52945	PDX1_HUMAN	pancreatic and duodenal homeobox 1	231					detection of glucose|generation of precursor metabolites and energy|insulin secretion|nitric oxide mediated signal transduction|organ morphogenesis|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter|type B pancreatic cell differentiation	nucleus	sequence-specific DNA binding transcription factor activity					all_cancers(110;0.175)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0402)|all cancers(112;0.0404)|OV - Ovarian serous cystadenocarcinoma(117;0.197)		GCCGTGACCTCCGGCGAGGAG	0.756000													7	4					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52520473	52520473	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:52520473C>T	ENST00000216286.5	-	5	1252	c.1253G>A	c.(1252-1254)gGa>gAa	p.G418E	NID2_ENST00000541773.1_Missense_Mutation_p.G365E	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	418						basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					CTGGATGCTTCCGTTTTCGGG	0.557000													17	40					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179584857	179584857	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:179584857C>T	ENST00000589042.1	-	81	23736	c.23512G>A	c.(23512-23514)Gag>Aag	p.E7838K	TTN_ENST00000591111.1_Missense_Mutation_p.E7521K|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.E6594K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7521	Ig-like 60.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTCACTCTCTCTGATGACT	0.438000													17	4					0	0	1	0	0
ABHD17A	81926	broad.mit.edu	37	19	1881266	1881266	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:1881266G>A	ENST00000292577.7	-	2	733	c.300C>T	c.(298-300)tcC>tcT	p.S100S	ABHD17A_ENST00000590661.1_Silent_p.S100S|ABHD17A_ENST00000250974.9_Silent_p.S100S	NM_001130111.1	NP_001123583.1			abhydrolase domain containing 17A																		CATACATGCAGGAGACGCGGT	0.667000													12	33					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8784469	8784469	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:8784469C>T	ENST00000359865.3	+	6	1501	c.1359C>T	c.(1357-1359)taC>taT	p.Y453Y	SOGA2_ENST00000306329.11_Silent_p.Y813Y|SOGA2_ENST00000517570.1_Silent_p.Y453Y|SOGA2_ENST00000400050.3_Silent_p.Y453Y|SOGA2_ENST00000306285.7_5'UTR	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	804																	ACTCTGAGTACCTAGTGACCC	0.642000													50	85					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137302	40137302	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:40137302C>T	ENST00000278198.2	-	2	2504	c.541G>A	c.(541-543)Gaa>Aaa	p.E181K	LRRC4C_ENST00000530763.1_Missense_Mutation_p.E181K|LRRC4C_ENST00000527150.1_Missense_Mutation_p.E181K|LRRC4C_ENST00000528697.1_Missense_Mutation_p.E181K			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	181					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				CTTTTCAATTCCCCTAAGTCT	0.438000													17	31					0	0	1	0	0
PPP6R1	22870	broad.mit.edu	37	19	55741983	55741983	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:55741983G>A	ENST00000412770.2	-	23	3206	c.2640C>T	c.(2638-2640)tcC>tcT	p.S880S	PPP6R1_ENST00000587283.1_Silent_p.S880S	NM_014931.3	NP_055746.3	Q9UPN7	PP6R1_HUMAN	protein phosphatase 6, regulatory subunit 1	880					regulation of phosphoprotein phosphatase activity	cytoplasm	protein phosphatase binding			breast(1)	1						ACACTCACTGGGAGCCTGGGG	0.657000													7	15					0	0	1	0	0
NPBWR2	2832	broad.mit.edu	37	20	62737457	62737457	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:62737457C>T	ENST00000369768.1	-	1	1067	c.728G>A	c.(727-729)cGg>cAg	p.R243Q		NM_005286.2	NP_005277.2	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	243						plasma membrane	opioid receptor activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					AGAGCGGAGCCGCACGGCCCG	0.667000													6	13					0	0	1	0	0
CD53	963	broad.mit.edu	37	1	111434995	111434995	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:111434995G>A	ENST00000271324.5	+	3	204	c.92G>A	c.(91-93)gGg>gAg	p.G31E	CD53_ENST00000429072.2_Missense_Mutation_p.G31E	NM_000560.3|NM_001040033.1	NP_000551.1|NP_001035122.1	P19397	CD53_HUMAN	CD53 molecule	31					signal transduction	integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(6)	17		all_cancers(81;1.06e-05)|all_epithelial(167;1.95e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0264)|Colorectal(144;0.0375)|all cancers(265;0.11)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.141)|LUSC - Lung squamous cell carcinoma(189;0.144)		TTGGGCTTTGGGATCTACCTG	0.483000													23	40					0	0	1	0	0
OR4N2	390429	broad.mit.edu	37	14	20295725	20295725	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:20295725C>T	ENST00000315947.1	+	1	118	c.118C>T	c.(118-120)Cct>Tct	p.P40S	OR4N2_ENST00000568211.1_Missense_Mutation_p.P40S	NM_001004723.1	NP_001004723.1	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N, member 2	40					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(1)|lung(32)|ovary(2)|prostate(1)|skin(2)|stomach(2)	52	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CATCATCCTCCCTGGAAATTT	0.438000													50	246					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77763549	77763549	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:77763549C>T	ENST00000521891.2	+	10	4840	c.4392C>T	c.(4390-4392)ccC>ccT	p.P1464P	ZFHX4_ENST00000518282.1_Silent_p.P1438P|ZFHX4_ENST00000050961.6_Silent_p.P1419P|ZFHX4_ENST00000455469.2_Silent_p.P1419P	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1419						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P1464P(1)		NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCTCCTTGCCCGTGAATGGAG	0.507000										HNSCC(33;0.089)			4	13					0	0	1	0	0
CCT8L2	150160	broad.mit.edu	37	22	17072481	17072481	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:17072481C>T	ENST00000359963.3	-	1	1219	c.960G>A	c.(958-960)tgG>tgA	p.W320*		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	320			W -> R (in dbSNP:rs2236639).		cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				TGATCTCCATCCAAGACCTAG	0.567000													56	72					0	0	1	0	0
SFXN3	81855	broad.mit.edu	37	10	102799292	102799292	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:102799292C>T	ENST00000393459.1	+	12	1389	c.916C>T	c.(916-918)Cat>Tat	p.H306Y	SFXN3_ENST00000466982.1_3'UTR|SFXN3_ENST00000224807.5_Missense_Mutation_p.H310Y			Q9BWM7	SFXN3_HUMAN	sideroflexin 3	310					iron ion homeostasis	integral to membrane|mitochondrial membrane	cation transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	9		Colorectal(252;0.234)		Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		AGCTCAGATCCATGAGCAAAA	0.537000													38	16					0	0	1	0	0
SLC2A4RG	56731	broad.mit.edu	37	20	62373342	62373342	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:62373342C>T	ENST00000266077.2	+	4	564	c.512C>T	c.(511-513)cCg>cTg	p.P171L	SLC2A4RG_ENST00000493772.1_Intron	NM_020062.3	NP_064446.2	Q9NR83	S2A4R_HUMAN	SLC2A4 regulator	171						cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|lung(2)|prostate(2)|skin(1)	7	all_cancers(38;1.13e-12)|all_epithelial(29;2.64e-14)|Lung NSC(23;4.79e-10)|all_lung(23;1.7e-09)					CCGTCCACCCCGTCACCCCCA	0.682000													11	25					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3425305	3425305	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:3425305G>A	ENST00000336727.3	+	13	4075	c.3171G>A	c.(3169-3171)acG>acA	p.T1057T	RGS12_ENST00000382788.3_Silent_p.T1057T|RGS12_ENST00000344733.5_Silent_p.T1057T|RGS12_ENST00000338806.4_Silent_p.T409T|RGS12_ENST00000538395.1_Silent_p.T399T|RGS12_ENST00000306648.7_Silent_p.T455T|RGS12_ENST00000508158.1_3'UTR	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	1057	RBD 2.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AGCCCGTCACGGAGGTGCTGC	0.622000													11	23					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236143954	236143954	+	Splice_Site	SNP	C	C	T	rs142491705	by1000genomes	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:236143954C>T	ENST00000264187.6	-	17	3310		c.e17-1		NID1_ENST00000366595.3_Splice_Site	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1						cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GTAAAGGTTCCTGGAGGAGGA	0.433000													4	11					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144874824	144874824	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:144874824G>A	ENST00000369359.4	-	33	5230	c.5192C>T	c.(5191-5193)tCc>tTc	p.S1731F	PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.S1551F|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.S1595F|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.S1731F|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.S1595F			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1595					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ATGGCTGCTGGAGGGTGTGAG	0.592000			T	PDGFRB	MPD								17	89					0	0	1	0	0
EGF	1950	broad.mit.edu	37	4	110908998	110908998	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:110908998G>A	ENST00000265171.5	+	17	3035	c.2590G>A	c.(2590-2592)Gat>Aat	p.D864N	EGF_ENST00000509793.1_Missense_Mutation_p.D822N|EGF_ENST00000503392.1_Missense_Mutation_p.D864N	NM_001178130.1|NM_001963.4	NP_001171601.1|NP_001954.2	P01133	EGF_HUMAN	epidermal growth factor	864	EGF-like 6.				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	ATTTGCTGGGGATGGAAAACT	0.423000													15	32					0	0	1	0	0
PRKRIR	5612	broad.mit.edu	37	11	76062171	76062171	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:76062171G>A	ENST00000260045.3	-	5	2128	c.2023C>T	c.(2023-2025)Cct>Tct	p.P675S		NM_004705.2	NP_004696.2	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	675					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			cervix(1)|endometrium(3)|large_intestine(4)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	25						TACACATTAGGAAAAAACTTG	0.428000													19	29					0	0	1	0	0
LHX6	26468	broad.mit.edu	37	9	124979378	124979378	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:124979378C>T	ENST00000394319.4	-	5	755	c.651G>A	c.(649-651)atG>atA	p.M217I	LHX6_ENST00000559895.1_Start_Codon_SNP_p.M1I|LHX6_ENST00000373755.2_Missense_Mutation_p.M188I|LHX6_ENST00000340587.3_Missense_Mutation_p.M217I|LHX6_ENST00000373754.2_Missense_Mutation_p.M188I|LHX6_ENST00000541397.2_Missense_Mutation_p.M206I	NM_014368.4	NP_055183.2	Q9UPM6	LHX6_HUMAN	LIM homeobox 6	188					cell maturation|cerebral cortex GABAergic interneuron migration|cerebral cortex radially oriented cell migration|cerebral cortex tangential migration	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(5)	8						GGTTCTCAATCATGGTGTCGT	0.652000													25	15					0	0	1	0	0
KRT32	3882	broad.mit.edu	37	17	39619290	39619290	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:39619290C>T	ENST00000225899.3	-	6	1112	c.1009G>A	c.(1009-1011)Gaa>Aaa	p.E337K		NM_002278.3	NP_002269.3	Q14532	K1H2_HUMAN	keratin 32	337	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(137;0.000812)				AGCGTGTTTTCCAGGGAGTCC	0.557000													17	41					0	0	1	0	0
CRMP1	1400	broad.mit.edu	37	4	5853183	5853183	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:5853183G>A	ENST00000324989.7	-	5	922	c.834C>T	c.(832-834)ttC>ttT	p.F278F	CRMP1_ENST00000511535.1_5'UTR|CRMP1_ENST00000512574.1_Silent_p.F162F|CRMP1_ENST00000397890.2_Silent_p.F164F	NM_001014809.1	NP_001014809.1	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1	164					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			NS(1)|cervix(2)|endometrium(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36				Colorectal(103;0.0721)		TGTAGACTTGGAAGGAATTGA	0.443000													35	63					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560697	44560697	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:44560697C>T	ENST00000332567.4	-	1	1291	c.939G>A	c.(937-939)tcG>tcA	p.S313S	KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	313					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						TCTTCTTGTTCGAGTGACTGT	0.617000													50	86					0	0	1	0	0
NPTXR	23467	broad.mit.edu	37	22	39218696	39218696	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:39218696G>A	ENST00000333039.2	-	5	1544	c.1421C>T	c.(1420-1422)cCc>cTc	p.P474L		NM_014293.3	NP_055108.2	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	474	Pentaxin.					integral to membrane	metal ion binding			central_nervous_system(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	Melanoma(58;0.04)					GTCTTCCCAGGGAAGGACGTT	0.617000													6	40					0	0	1	0	0
TRPC4	7223	broad.mit.edu	37	13	38357368	38357368	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:38357368C>T	ENST00000379705.3	-	2	960	c.103G>A	c.(103-105)Gcc>Acc	p.A35T	TRPC4_ENST00000379681.3_Missense_Mutation_p.A35T|TRPC4_ENST00000358477.2_Missense_Mutation_p.A35T|TRPC4_ENST00000447043.1_Missense_Mutation_p.A35T|TRPC4_ENST00000355779.2_Missense_Mutation_p.A35T|TRPC4_ENST00000338947.5_Missense_Mutation_p.A35T|TRPC4_ENST00000426868.2_Missense_Mutation_p.A35T|TRPC4_ENST00000379673.2_Missense_Mutation_p.A35T|TRPC4_ENST00000379679.1_Missense_Mutation_p.A35T			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	35					axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TTCAAGTAGGCTTTTTCTGAT	0.383000													34	135					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57076535	57076535	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:57076535G>A	ENST00000532437.1	-	5	3961	c.3650C>T	c.(3649-3651)cCg>cTg	p.P1217L	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.P1217L			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1217	Acidic.|Gly-rich.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				GATTCCCCCCGGCTCTTCAGA	0.592000													91	133					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140262982	140262982	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140262982C>T	ENST00000289272.2	+	1	1129	c.1129C>T	c.(1129-1131)Cgt>Tgt	p.R377C	PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA13_ENST00000409494.1_Missense_Mutation_p.R377C|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTGTCCGATCGTGACTCTGG	0.507000													31	53					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55782690	55782690	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:55782690C>T	ENST00000373965.2	-	20	2903	c.2509G>A	c.(2509-2511)Gag>Aag	p.E837K	PCDH15_ENST00000395432.2_Missense_Mutation_p.E793K|PCDH15_ENST00000395433.1_Missense_Mutation_p.E808K|PCDH15_ENST00000373955.1_Missense_Mutation_p.E830K|PCDH15_ENST00000361849.3_Missense_Mutation_p.E830K|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000414778.1_Missense_Mutation_p.E835K|PCDH15_ENST00000409834.1_Missense_Mutation_p.E441K|PCDH15_ENST00000320301.6_Missense_Mutation_p.E830K|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395438.1_Missense_Mutation_p.E830K|PCDH15_ENST00000395430.1_Missense_Mutation_p.E830K|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395445.1_Missense_Mutation_p.E837K|PCDH15_ENST00000437009.1_Missense_Mutation_p.E759K|PCDH15_ENST00000395446.1_Intron	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	830	Cadherin 8.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GGCAAATTCTCTTCAACAAGG	0.408000										HNSCC(58;0.16)			26	12					0	0	1	0	0
PAK4	10298	broad.mit.edu	37	19	39664327	39664327	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:39664327C>T	ENST00000599386.1	+	4	497	c.316C>T	c.(316-318)Cct>Tct	p.P106S	PAK4_ENST00000360442.3_Missense_Mutation_p.P259S|PAK4_ENST00000321944.4_Missense_Mutation_p.P169S|PAK4_ENST00000358301.3_Missense_Mutation_p.P259S|PAK4_ENST00000593690.1_Missense_Mutation_p.P259S|PAK4_ENST00000435673.2_Missense_Mutation_p.P259S|PAK4_ENST00000599470.1_Missense_Mutation_p.P106S	NM_001014835.1	NP_001014835.1	O96013	PAK4_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 4	259	Linker.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	13	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			TGCCCCCAGCCCTGGAGTGCT	0.761000													3	4					0	0	1	0	0
SOWAHB	345079	broad.mit.edu	37	4	77817214	77817214	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:77817214C>T	ENST00000334306.2	-	1	1788	c.1789G>A	c.(1789-1791)Gag>Aag	p.E597K		NM_001029870.1	NP_001025041.1	A6NEL2	ANR56_HUMAN	sosondowah ankyrin repeat domain family member B	597																	CACTCATGCTCCCTGGCATCT	0.567000													20	23					0	0	1	0	0
CA2	760	broad.mit.edu	37	8	86377599	86377599	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:86377599A>G	ENST00000285379.5	+	2	363	c.133A>G	c.(133-135)Aag>Gag	p.K45E		NM_000067.2	NP_000058.1	P00918	CAH2_HUMAN	carbonic anhydrase II	45					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(2)|cervix(1)|large_intestine(2)|lung(5)|prostate(1)	11					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	CCCTTCCCTGAAGCCCCTGTC	0.517000													15	25					0	0	1	0	0
SALL2	6297	broad.mit.edu	37	14	21992636	21992636	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:21992636C>T	ENST00000327430.3	-	2	1520	c.1226G>A	c.(1225-1227)cGt>cAt	p.R409H	SALL2_ENST00000450879.2_Missense_Mutation_p.R272H|SALL2_ENST00000538754.1_Intron|SALL2_ENST00000317492.5_Intron	NM_005407.1	NP_005398.1	Q9Y467	SALL2_HUMAN	spalt-like transcription factor 2	409							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R409H(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(6)|urinary_tract(2)	43	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		GGTGGTAAAACGGTTTCCACA	0.537000													16	20					0	0	1	0	0
RQCD1	9125	broad.mit.edu	37	2	219447744	219447744	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:219447744C>T	ENST00000273064.6	+	3	630	c.255C>T	c.(253-255)caC>caT	p.H85H	RQCD1_ENST00000295701.5_Silent_p.H85H|RQCD1_ENST00000542068.1_Silent_p.H85H|RQCD1_ENST00000509807.2_Silent_p.H85H	NM_005444.2	NP_005435.1	Q92600	RCD1_HUMAN	RCD1 required for cell differentiation1 homolog (S. pombe)	85					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|sex differentiation|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|prostate(3)|skin(1)	15		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000192)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGACAGCACACCAGTCTAACA	0.383000													19	11					0	0	1	0	0
SCEL	8796	broad.mit.edu	37	13	78202140	78202140	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:78202140G>A	ENST00000535157.1	+	26	1731	c.1561G>A	c.(1561-1563)Gga>Aga	p.G521R	SCEL_ENST00000377246.3_Missense_Mutation_p.G543R|SCEL_ENST00000349847.3_Missense_Mutation_p.G563R	NM_001160706.1	NP_001154178.1	O95171	SCEL_HUMAN	sciellin	563	16 X approximate tandem repeats.				embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(18)|ovary(5)|prostate(1)|stomach(1)|urinary_tract(1)	40		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		AAACAAGAATGGAAGGTAAAG	0.234000													10	32					0	0	1	0	0
PARP11	57097	broad.mit.edu	37	12	3921430	3921430	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:3921430G>A	ENST00000228820.4	-	8	1020	c.876C>T	c.(874-876)tcC>tcT	p.S292S	PARP11_ENST00000476985.1_Intron|PARP11_ENST00000427057.2_Silent_p.S211S|PARP11_ENST00000397096.2_Intron|PARP11_ENST00000447133.3_Silent_p.S211S	NM_020367.4	NP_065100.2	Q9NR21	PAR11_HUMAN	poly (ADP-ribose) polymerase family, member 11	285	PARP catalytic.						NAD+ ADP-ribosyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)	17			all cancers(3;1.58e-07)|OV - Ovarian serous cystadenocarcinoma(31;0.00287)|GBM - Glioblastoma multiforme(3;0.0141)|COAD - Colon adenocarcinoma(12;0.0264)			GCATGTATTTGGAGTCTCCGT	0.408000													26	21					0	0	1	0	0
KCNJ4	3761	broad.mit.edu	37	22	38823753	38823753	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:38823753C>T	ENST00000303592.3	-	2	643	c.385G>A	c.(385-387)Gtg>Atg	p.V129M		NM_004981.1|NM_152868.2	NP_004972.1|NP_690607.1	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 4	129					synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding			endometrium(7)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	23	Melanoma(58;0.0286)					TGCGTCTCCACCGAGAACAGG	0.692000													33	75					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28659935	28659935	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:28659935G>A	ENST00000280904.6	-	11	1984	c.1541C>T	c.(1540-1542)cCa>cTa	p.P514L	DSC2_ENST00000251081.6_Missense_Mutation_p.P514L	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	514	Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			CCACCCTGTTGGATCAGTTAA	0.289000													32	61					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55943312	55943312	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:55943312G>A	ENST00000373965.2	-	14	1897	c.1503C>T	c.(1501-1503)atC>atT	p.I501I	PCDH15_ENST00000395432.2_Silent_p.I457I|PCDH15_ENST00000395433.1_Silent_p.I472I|PCDH15_ENST00000373955.1_Silent_p.I494I|PCDH15_ENST00000361849.3_Silent_p.I494I|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000414778.1_Silent_p.I499I|PCDH15_ENST00000409834.1_Silent_p.I105I|PCDH15_ENST00000320301.6_Silent_p.I494I|PCDH15_ENST00000373957.3_Silent_p.I472I|PCDH15_ENST00000395438.1_Silent_p.I494I|PCDH15_ENST00000395430.1_Silent_p.I494I|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395445.1_Silent_p.I501I|PCDH15_ENST00000437009.1_Silent_p.I494I|PCDH15_ENST00000395446.1_Silent_p.I494I	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	494	Cadherin 4.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GAATATTGACGATGACTGGCT	0.393000										HNSCC(58;0.16)			18	7					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881145	228881145	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:228881145G>A	ENST00000392056.3	-	7	4471	c.4425C>T	c.(4423-4425)gcC>gcT	p.A1475A	SPHKAP_ENST00000344657.5_Silent_p.A1475A	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1475						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		AAGCGCTCACGGCTGTGTCTC	0.463000													30	15					0	0	1	0	0
CDK7	1022	broad.mit.edu	37	5	68572406	68572406	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:68572406C>T	ENST00000502604.1	+	10	1112	c.622C>T	c.(622-624)Cca>Tca	p.P208S	CDK7_ENST00000514676.1_Missense_Mutation_p.P264S|CDK7_ENST00000256443.3_Missense_Mutation_p.P301S			P50613	CDK7_HUMAN	cyclin-dependent kinase 7	301	Protein kinase.				androgen receptor signaling pathway|cell division|cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex|mitochondrion	androgen receptor binding|ATP binding|cyclin-dependent protein kinase activity|DNA-dependent ATPase activity|protein C-terminus binding|RNA polymerase II carboxy-terminal domain kinase activity|transcription coactivator activity			endometrium(1)|lung(2)	3		Lung NSC(167;7.26e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.98e-56)|Epithelial(20;3.54e-52)|all cancers(19;9.11e-48)|Lung(70;0.0185)		TCGGCCAGGGCCAACACCTGG	0.403000								Nucleotide excision repair (NER)					14	21					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164777775	164777775	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:164777775C>T	ENST00000264382.3	-	10	1123	c.1061G>A	c.(1060-1062)gGa>gAa	p.G354E		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	354	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TAGTTGGAATCCAAGATTCCA	0.343000										HNSCC(35;0.089)			42	58					0	0	1	0	0
KDM3B	51780	broad.mit.edu	37	5	137727454	137727454	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:137727454C>T	ENST00000314358.5	+	8	2333	c.2133C>T	c.(2131-2133)acC>acT	p.T711T	KDM3B_ENST00000542866.1_Intron|KDM3B_ENST00000394866.1_Silent_p.T367T	NM_016604.3	NP_057688.2	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	711	Ser-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						CAGCTCTTACCAGTGGGGGCC	0.557000													14	44					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1645433	1645433	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:1645433G>A	ENST00000421627.2	+	11	2811	c.2677G>A	c.(2677-2679)Gac>Aac	p.D893N		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	972					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		GCGGCTCAACGACTGGAAGAT	0.607000													20	33					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77693917	77693917	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:77693917G>A	ENST00000461745.1	+	25	4897	c.3997G>A	c.(3997-3999)Gga>Aga	p.G1333R	ROBO2_ENST00000487694.3_Missense_Mutation_p.G1349R|ROBO2_ENST00000332191.8_Missense_Mutation_p.G1394R	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	1333					apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CAGCTCATCAGGAACAGCTTC	0.498000													15	28					0	0	1	0	0
ZCWPW1	55063	broad.mit.edu	37	7	100002657	100002657	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:100002657C>T	ENST00000398027.2	-	13	1477	c.1230G>A	c.(1228-1230)gaG>gaA	p.E410E	ZCWPW1_ENST00000324725.6_Silent_p.E290E|ZCWPW1_ENST00000360951.4_Silent_p.E411E|ZCWPW1_ENST00000490721.1_Silent_p.E290E	NM_017984.4	NP_060454.3	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	410							zinc ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)	16	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TCTGTTCTGCCTCTTGAGCCA	0.463000													47	67					0	0	1	0	0
TRPM5	29850	broad.mit.edu	37	11	2427956	2427956	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:2427956G>A	ENST00000452833.1	-	21	3200	c.3192C>T	c.(3190-3192)ttC>ttT	p.F1064F	TRPM5_ENST00000155858.6_Silent_p.F1062F|AC124057.5_ENST00000433035.1_RNA|TRPM5_ENST00000528453.1_Silent_p.F1062F|TRPM5_ENST00000533060.1_Silent_p.F1062F			Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel, subfamily M, member 5	1062						integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(4)|liver(1)|lung(8)|ovary(2)|prostate(2)|skin(2)|urinary_tract(2)	23		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		TCTTGCTCAGGAAGTTCTCCT	0.617000													19	56					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10443871	10443871	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:10443871C>T	ENST00000397077.1	-	6	1134	c.559G>A	c.(559-561)Gag>Aag	p.E187K	ATP2B2_ENST00000383800.4_Missense_Mutation_p.E187K|ATP2B2_ENST00000360273.2_Missense_Mutation_p.E187K|ATP2B2_ENST00000352432.4_Missense_Mutation_p.E187K|ATP2B2_ENST00000343816.4_Missense_Mutation_p.E187K			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	187					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						TGTTCCTGCTCGATGCGGCTC	0.572000													68	112					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152326071	152326071	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:152326071C>T	ENST00000388718.5	-	3	4263	c.4191G>A	c.(4189-4191)gaG>gaA	p.E1397E	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1397							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCCAGTGGCCTCTCCTGTCT	0.507000													52	106					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37730433	37730433	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:37730433G>A	ENST00000330843.4	-	4	1899	c.1887C>T	c.(1885-1887)ccC>ccT	p.P629P	RAB11FIP1_ENST00000287263.4_Intron|RAB11FIP1_ENST00000524118.1_Intron|RAB11FIP1_ENST00000522727.1_Intron|RAB11FIP1_ENST00000523182.1_5'UTR	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	629					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			TAGGGAGCAAGGGTGGTCCTT	0.517000													22	38					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22951144	22951144	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:22951144C>T	ENST00000397104.3	-	3	251	c.252G>A	c.(250-252)tgG>tgA	p.W84*	ZNF99_ENST00000596209.1_Nonsense_Mutation_p.W63*					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TCTTCATATTCCAAGGCTCTT	0.378000													7	15					0	0	1	0	0
TEX26	122046	broad.mit.edu	37	13	31540398	31540398	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:31540398G>A	ENST00000380473.3	+	5	522	c.509G>A	c.(508-510)tGg>tAg	p.W170*	TEX26_ENST00000530916.1_Intron	NM_152325.1	NP_689538.1	Q8N6G2	CM026_HUMAN	testis expressed 26	170																	TCTCTGGAATGGAAAAAGTTA	0.398000													10	38					0	0	1	0	0
PITPNA	5306	broad.mit.edu	37	17	1444865	1444865	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:1444865C>T	ENST00000313486.7	-	6	622	c.367G>A	c.(367-369)Gag>Aag	p.E123K	PITPNA_ENST00000539476.1_Missense_Mutation_p.E123K	NM_006224.3	NP_006215.1	Q00169	PIPNA_HUMAN	phosphatidylinositol transfer protein, alpha	123					axon guidance|lipid metabolic process|visual perception	cytoplasm	phosphatidylcholine transmembrane transporter activity|phosphatidylinositol transporter activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)	7				UCEC - Uterine corpus endometrioid carcinoma (25;0.0845)		CTCACATTCTCCTGCGTGCCA	0.468000													13	5					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179577814	179577814	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:179577814C>T	ENST00000589042.1	-	93	27271	c.27047G>A	c.(27046-27048)aGa>aAa	p.R9016K	TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R8699K|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R7772K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8699	Ig-like 73.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAACTGACCTCTCACAGTCAA	0.348000													10	3					0	0	1	0	0
PAGE5	90737	broad.mit.edu	37	X	55249119	55249119	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:55249119G>A	ENST00000289619.5	+	4	561	c.316G>A	c.(316-318)Ggt>Agt	p.G106S	PAGE5_ENST00000374955.3_Missense_Mutation_p.G86S|PAGE5_ENST00000374952.1_Missense_Mutation_p.G69S	NM_130467.3	NP_569734.2	Q96GU1	GGEE1_HUMAN	P antigen family, member 5 (prostate associated)	106										breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8						ACCTGGAGATGGTCCTGATGT	0.413000													31	55					0	0	1	0	0
ARRDC2	27106	broad.mit.edu	37	19	18121020	18121020	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:18121020C>T	ENST00000222250.4	+	6	1008	c.865C>T	c.(865-867)Cca>Tca	p.P289S	ARRDC2_ENST00000379656.2_Missense_Mutation_p.P284S	NM_015683.1	NP_056498.1	Q8TBH0	ARRD2_HUMAN	arrestin domain containing 2	289										endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)	12						TGTGGATATCCCAGGAACGTC	0.637000													25	33					0	0	1	0	0
PIP5K1A	8394	broad.mit.edu	37	1	151214996	151214996	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:151214996C>T	ENST00000409426.1	+	13	2002	c.1557C>T	c.(1555-1557)ccC>ccT	p.P519P	PIP5K1A_ENST00000368888.4_Silent_p.P531P|PIP5K1A_ENST00000368890.4_Silent_p.P469P|PIP5K1A_ENST00000441902.2_Silent_p.P491P|PIP5K1A_ENST00000414290.2_Intron			Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	531					phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			breast(1)|central_nervous_system(1)|ovary(1)|skin(1)|stomach(1)	5	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			TTCCTGACCCCAGTTTCTCAC	0.448000													19	37					0	0	1	0	0
ZNF211	10520	broad.mit.edu	37	19	58152153	58152153	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:58152153C>T	ENST00000544273.1	+	5	662	c.335C>T	c.(334-336)tCc>tTc	p.S112F	ZNF211_ENST00000347302.3_Missense_Mutation_p.S100F|ZNF211_ENST00000299871.5_Missense_Mutation_p.S165F|ZNF211_ENST00000391703.3_Missense_Mutation_p.S39F|ZNF211_ENST00000420680.1_Missense_Mutation_p.S104F|ZNF211_ENST00000254182.7_Missense_Mutation_p.S91F|ZNF211_ENST00000541801.1_Missense_Mutation_p.S91F|ZNF211_ENST00000240731.4_Missense_Mutation_p.S113F			Q13398	ZN211_HUMAN	zinc finger protein 211	100						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTCAGGACTTCCAAAGAAGGT	0.438000													12	14					0	0	1	0	0
ZNF254	9534	broad.mit.edu	37	19	24309303	24309303	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:24309303A>T	ENST00000357002.4	+	4	616	c.501A>T	c.(499-501)ttA>ttT	p.L167F	ZNF254_ENST00000342944.6_Missense_Mutation_p.L82F	NM_001278661.1|NM_001278662.1|NM_001278664.1|NM_001278677.1|NM_001278678.1|NM_203282.2	NP_001265590.1|NP_001265591.1|NP_001265593.1|NP_001265606.1|NP_001265607.1|NP_975011.3	O75437	ZN254_HUMAN	zinc finger protein 254	167					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding						all_cancers(12;0.086)|all_lung(12;0.00528)|Lung NSC(12;0.00731)|all_epithelial(12;0.0186)				ATAAATTTTTAAATTCAAACA	0.294000													15	27					0	0	1	0	0
RARRES1	5918	broad.mit.edu	37	3	158415517	158415517	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:158415517C>T	ENST00000237696.5	-	6	1115	c.835G>A	c.(835-837)Gga>Aga	p.G279R		NM_206963.1	NP_996846.1	P49788	TIG1_HUMAN	retinoic acid receptor responder (tazarotene induced) 1	279					negative regulation of cell proliferation	integral to membrane				NS(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)	9			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)		Tretinoin(DB00755)	TCTTCAGTTCCGGAGGCTTCT	0.413000													17	36					0	0	1	0	0
IL17RE	132014	broad.mit.edu	37	3	9952711	9952711	+	Missense_Mutation	SNP	G	G	A	rs138199794		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:9952711G>A	ENST00000454190.2	+	9	1050	c.965G>A	c.(964-966)cGa>cAa	p.R322Q	IL17RE_ENST00000421412.1_Missense_Mutation_p.R355Q|IL17RE_ENST00000295980.3_Missense_Mutation_p.R322Q|IL17RE_ENST00000383814.3_Missense_Mutation_p.R322Q	NM_001193380.1	NP_001180309.1	Q8NFR9	I17RE_HUMAN	interleukin 17 receptor E	322						cytoplasm|extracellular region|integral to membrane	receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(11)|skin(1)	21				OV - Ovarian serous cystadenocarcinoma(96;5.34e-64)		GCCACAGCTCGAGAGTCAGAT	0.612000													11	28					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121383805	121383805	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:121383805C>T	ENST00000260197.7	+	7	1162	c.1033C>T	c.(1033-1035)Cct>Tct	p.P345S	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	345					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CACAAGACATCCTATTAATGT	0.522000													18	21					0	0	1	0	0
KIAA1683	80726	broad.mit.edu	37	19	18376908	18376908	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:18376908G>A	ENST00000392413.3	-	3	1657	c.1442C>T	c.(1441-1443)tCc>tTc	p.S481F	KIAA1683_ENST00000600328.2_Missense_Mutation_p.S481F|KIAA1683_ENST00000600359.2_Missense_Mutation_p.S435F	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	481						mitochondrion				breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						GCTCCTCTGGGATGAAGTCTT	0.602000													25	40					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56243633	56243633	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:56243633C>T	ENST00000332836.2	-	2	1591	c.1564G>A	c.(1564-1566)Gaa>Aaa	p.E522K		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	522						cytoplasm	ATP binding	p.E522K(1)		NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		TGGGTTATTTCCTGCTTTAGG	0.413000													30	33					0	0	1	0	0
PTCHD4	442213	broad.mit.edu	37	6	47846142	47846142	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:47846142G>A	ENST00000339488.4	-	3	2471	c.2438C>T	c.(2437-2439)tCc>tTc	p.S813F		NM_001013732.3	NP_001013754.3	Q6ZW05	CF138_HUMAN	patched domain containing 4	813						integral to membrane	hedgehog receptor activity										GTGCTTTTTGGAAGGGGGGAA	0.448000													20	65					0	0	1	0	0
GATA5	140628	broad.mit.edu	37	20	61041534	61041534	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:61041534G>A	ENST00000252997.2	-	4	834	c.773C>T	c.(772-774)tCg>tTg	p.S258L		NM_080473.4	NP_536721.1	Q9BWX5	GATA5_HUMAN	GATA binding protein 5	258					blood coagulation|intestinal epithelial cell differentiation|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			kidney(1)|lung(3)|ovary(1)|stomach(1)	6	Breast(26;2.05e-08)		BRCA - Breast invasive adenocarcinoma(19;3.08e-06)			CTCCCCCTCCGAGTTCCGCCG	0.701000													3	5					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70953392	70953392	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:70953392G>A	ENST00000334414.6	-	18	4489	c.4445C>T	c.(4444-4446)cCc>cTc	p.P1482L	PTPRB_ENST00000550358.1_Missense_Mutation_p.P1394L|PTPRB_ENST00000538708.1_Missense_Mutation_p.P1174L|PTPRB_ENST00000451516.2_Missense_Mutation_p.P1174L|PTPRB_ENST00000550857.1_Missense_Mutation_p.P1174L|PTPRB_ENST00000551525.1_Missense_Mutation_p.P1481L|PTPRB_ENST00000261266.5_Missense_Mutation_p.P1264L	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1264	Fibronectin type-III 17.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CATAAGACTGGGAGGACTTGG	0.448000													15	22					0	0	1	0	0
TJP1	7082	broad.mit.edu	37	15	30025312	30025312	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:30025312G>A	ENST00000346128.6	-	13	2196	c.1722C>T	c.(1720-1722)atC>atT	p.I574I	TJP1_ENST00000400011.2_Silent_p.I578I|TJP1_ENST00000545208.2_Silent_p.I574I|TJP1_ENST00000356107.6_Silent_p.I574I	NM_003257.3|NM_175610.2	NP_003248.3|NP_783297.2	Q07157	ZO1_HUMAN	tight junction protein 1	574	SH3.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				breast(4)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(12)|liver(1)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(1)	68		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TCTTATTAGGGATGATGCCTC	0.388000													11	26					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75078449	75078449	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:75078449T>G	ENST00000326665.5	-	9	1263	c.1045A>C	c.(1045-1047)Agt>Cgt	p.S349R	RP4-612J11.1_ENST00000416017.1_RNA|C1orf173_ENST00000420661.2_Missense_Mutation_p.S152R	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	349										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						AAGGTGAGACTGAAGGGGAAA	0.428000													9	18					0	0	1	0	0
CARD11	84433	broad.mit.edu	37	7	2951926	2951926	+	Silent	SNP	G	G	A	rs148497800	by1000genomes	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:2951926G>A	ENST00000396946.4	-	23	3427	c.3024C>T	c.(3022-3024)atC>atT	p.I1008I		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	1008	Guanylate kinase-like.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CTCTTGTGACGATATCTGCAG	0.582000			Mis		DLBCL								13	17					0	0	1	0	0
IGSF3	3321	broad.mit.edu	37	1	117122291	117122291	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:117122291C>G	ENST00000369486.3	-	10	3822	c.3057G>C	c.(3055-3057)gaG>gaC	p.E1019D	IGSF3_ENST00000369483.1_Missense_Mutation_p.E1039D|IGSF3_ENST00000318837.6_Missense_Mutation_p.E1039D	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	1019	Ig-like C2-type 8.					integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		cgtcgtcgtcctcctcctcct	0.637000													3	13					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62045514	62045514	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:62045514C>T	ENST00000435607.1	-	6	981	c.905G>A	c.(904-906)gGc>gAc	p.G302D	SCN4A_ENST00000578147.1_Missense_Mutation_p.G302D	NM_000334.4	NP_000325.4	P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	302					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	TGTGTCATTGCCGTACCACGT	0.557000													4	166					0	0	1	0	0
FOXR1	283150	broad.mit.edu	37	11	118850182	118850182	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:118850182G>A	ENST00000317011.3	+	4	640	c.415G>A	c.(415-417)Gaa>Aaa	p.E139K		NM_181721.2	NP_859072.1	Q6PIV2	FOXR1_HUMAN	forkhead box R1	139					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		TGAGGACCAGGAAGACAGCTC	0.622000													16	24					0	0	1	0	0
SLC25A12	8604	broad.mit.edu	37	2	172700881	172700881	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:172700881G>A	ENST00000422440.2	-	5	500	c.463C>T	c.(463-465)Cag>Tag	p.Q155*	SLC25A12_ENST00000472748.1_5'UTR|SLC25A12_ENST00000392592.4_Nonsense_Mutation_p.Q48*	NM_003705.4	NP_003696.2	O75746	CMC1_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 12	155	EF-hand 3.				gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(10)|upper_aerodigestive_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.216)		L-Aspartic Acid(DB00128)	AAGCTCACCTGGAGAAACTGC	0.348000													23	6					0	0	1	0	0
DEGS2	123099	broad.mit.edu	37	14	100615479	100615479	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:100615479G>A	ENST00000305631.5	-	2	1226	c.651C>T	c.(649-651)ttC>ttT	p.F217F	DEGS2_ENST00000553834.1_Intron|DEGS2_ENST00000557117.1_5'UTR	NM_206918.2	NP_996801.2	Q6QHC5	DEGS2_HUMAN	delta(4)-desaturase, sphingolipid 2	217					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	sphingosine hydroxylase activity			breast(1)|lung(6)|skin(1)	8		Melanoma(154;0.212)				CCAGGCCCAGGAAGGAGCTGG	0.637000													34	52					0	0	1	0	0
WNT6	7475	broad.mit.edu	37	2	219735749	219735749	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:219735749G>A	ENST00000233948.3	+	2	298	c.80_splice	c.e2-1	p.W27_splice	WNT6_ENST00000486233.1_Intron	NM_006522.3	NP_006513.1	Q9Y6F9	WNT6_HUMAN	wingless-type MMTV integration site family, member 6	27					anterior/posterior pattern formation|axis specification|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|cornea development in camera-type eye|neuron differentiation|odontogenesis of dentine-containing tooth|positive regulation of gene expression|positive regulation of tooth mineralization|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			large_intestine(1)|ovary(2)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.53e-07)|all cancers(144;9.3e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TGCTTTCCAGGGCTGTGGGCA	0.652000													48	21					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135431321	135431321	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:135431321C>T	ENST00000394143.1	+	6	5747	c.5456C>T	c.(5455-5457)tCa>tTa	p.S1819L	GPR112_ENST00000287534.4_Missense_Mutation_p.S1756L|GPR112_ENST00000412101.1_Missense_Mutation_p.S1614L|GPR112_ENST00000370652.1_Missense_Mutation_p.S1819L|GPR112_ENST00000394141.1_Missense_Mutation_p.S1614L	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1819					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					ACCCCTGTTTCATACCCTCCA	0.403000													34	48					0	0	1	0	0
CCL11	6356	broad.mit.edu	37	17	32614654	32614654	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:32614654G>A	ENST00000305869.3	+	3	380	c.239G>A	c.(238-240)tGg>tAg	p.W80*		NM_002986.2	NP_002977.1	P51671	CCL11_HUMAN	chemokine (C-C motif) ligand 11	80					cell adhesion|cellular calcium ion homeostasis|immune response|positive regulation of actin filament polymerization|positive regulation of cell migration|positive regulation of endothelial cell proliferation|positive regulation of Rac GTPase activity|protein phosphorylation|response to radiation|response to virus|signal transduction	extracellular space	chemokine activity			breast(1)|lung(1)|prostate(1)	3	Breast(3;0.00224)	Breast(31;0.151)|Ovarian(249;0.17)		BRCA - Breast invasive adenocarcinoma(366;0.155)		AAGAAGAAGTGGGTGCAGGAT	0.438000													6	16					0	0	1	0	0
PTPRR	5801	broad.mit.edu	37	12	71050529	71050529	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:71050529C>T	ENST00000283228.2	-	13	2287	c.1835G>A	c.(1834-1836)gGa>gAa	p.G612E	PTPRR_ENST00000342084.4_Missense_Mutation_p.G500E|PTPRR_ENST00000537619.2_5'UTR|PTPRR_ENST00000378778.1_Missense_Mutation_p.G406E|PTPRR_ENST00000440835.2_Missense_Mutation_p.G367E|PTPRR_ENST00000549308.1_Missense_Mutation_p.G367E	NM_002849.3	NP_002840.2	Q15256	PTPRR_HUMAN	protein tyrosine phosphatase, receptor type, R	612	Tyrosine-protein phosphatase.				in utero embryonic development	cell surface|Golgi apparatus|integral to membrane|nucleus|perinuclear region of cytoplasm|plasma membrane	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(2;5.67e-07)|Lung(24;0.00283)|OV - Ovarian serous cystadenocarcinoma(12;0.00578)|LUSC - Lung squamous cell carcinoma(43;0.132)	COAD - Colon adenocarcinoma(1;0.136)		ATCCACAACTCCTTCTTCTTT	0.423000													24	42					0	0	1	0	0
RGS19	10287	broad.mit.edu	37	20	62705374	62705374	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:62705374C>T	ENST00000395042.1	-	6	752	c.486G>A	c.(484-486)cgG>cgA	p.R162R	RGS19_ENST00000332298.5_Silent_p.R162R	NM_005873.2	NP_005864.1	P49795	RGS19_HUMAN	regulator of G-protein signaling 19	162	RGS.				autophagy|G-protein coupled receptor protein signaling pathway|negative regulation of signal transduction|small GTPase mediated signal transduction	Golgi apparatus|membrane fraction|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			lung(1)|prostate(1)|skin(1)	3	all_cancers(38;3.45e-11)|all_epithelial(29;9.12e-13)|Lung NSC(23;2e-09)|all_lung(23;6.77e-09)					TGATGCCCTCCCGCACACGGG	0.662000													24	28					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27455916	27455916	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:27455916C>T	ENST00000337929.3	+	6	1034	c.561C>T	c.(559-561)ccC>ccT	p.P187P	IL21R_ENST00000395754.4_Silent_p.P187P|IL21R_ENST00000564583.1_3'UTR|IL21R_ENST00000395755.1_Silent_p.P187P|IL21R_ENST00000564089.1_Silent_p.P187P	NM_181078.2	NP_851564.1	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor	187	Fibronectin type-III.				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			breast(2)|large_intestine(3)|lung(1)|ovary(2)	8						CCCTCCTCCCCCTGGAGTTCC	0.597000			T	BCL6	NHL								22	26					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141740641	141740641	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:141740641G>A	ENST00000475668.2	+	21	2547	c.2493G>A	c.(2491-2493)ctG>ctA	p.L831L	MGAM_ENST00000549489.2_Silent_p.L831L			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	831	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CAACCACTCTGGCCAGGTATA	0.473000													12	23					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57430165	57430165	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:57430165C>T	ENST00000306120.3	+	1	1655	c.1655C>T	c.(1654-1656)cCt>cTt	p.P552L	GNAS_ENST00000371098.2_Intron|GNAS_ENST00000313949.7_Intron|GNAS_ENST00000603534.1_Intron|GNAS_ENST00000371099.2_Silent_p.A615A|GNAS_ENST00000371100.4_Silent_p.A615A|GNAS_ENST00000371102.4_Silent_p.A615A|GNAS_ENST00000371075.3_Intron|GNAS_ENST00000464624.2_3'UTR			P63092	GNAS2_HUMAN	GNAS complex locus	0					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			TCGTGCAAGCCTTCGGGGGCT	0.622000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			13	16					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54676263	54676263	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:54676263C>T	ENST00000474759.1	+	11	1210	c.1162C>T	c.(1162-1164)Cga>Tga	p.R388*	CACNA2D3_ENST00000288197.5_Nonsense_Mutation_p.R388*|CACNA2D3_ENST00000490478.1_Nonsense_Mutation_p.R294*|CACNA2D3_ENST00000415676.2_Nonsense_Mutation_p.R388*	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	388	VWFA.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		TTGGCCAGATCGAAAGGTAAG	0.468000													8	5					0	0	1	0	0
ZNF716	441234	broad.mit.edu	37	7	57528531	57528531	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:57528531G>A	ENST00000420713.1	+	4	476	c.364G>A	c.(364-366)Gat>Aat	p.D122N		NM_001159279.1	NP_001152751.1			zinc finger protein 716											breast(1)|kidney(1)|lung(20)|ovary(2)	24						TGGACAGGAGGATTTACAAGT	0.378000													11	19					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229265	140229265	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140229265C>T	ENST00000378122.3	+	1	1909	c.1185C>T	c.(1183-1185)ttC>ttT	p.F395F	PCDHA9_ENST00000532602.1_Silent_p.F395F|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGTCCCCTTCAAGCTGGTGT	0.587000													38	72					0	0	1	0	0
ABL1	25	broad.mit.edu	37	9	133760068	133760068	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:133760068C>T	ENST00000318560.5	+	11	2772	c.2391C>T	c.(2389-2391)gtC>gtT	p.V797V		NM_005157.4	NP_005148.2	P00519	ABL1_HUMAN	c-abl oncogene 1, non-receptor tyrosine kinase	797	Pro-rich.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			breast(3)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1149)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	1195		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	CTGATGAGGTCTTCAAAGACA	0.637000			"""T, Mis"""	"""BCR, ETV6, NUP214"""	"""CML, ALL, T-ALL"""								4	2					0	0	1	0	0
ZFP2	80108	broad.mit.edu	37	5	178359140	178359140	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:178359140G>A	ENST00000361362.2	+	5	1356	c.826G>A	c.(826-828)Gga>Aga	p.G276R	ZFP2_ENST00000503510.2_Missense_Mutation_p.G276R|ZFP2_ENST00000520301.1_Missense_Mutation_p.G276R|ZFP2_ENST00000523286.1_Missense_Mutation_p.G276R	NM_030613.2	NP_085116.2	Q6ZN57	ZFP2_HUMAN	ZFP2 zinc finger protein	276					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	20	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		TAGTCAATGTGGAAAAGCCTT	0.393000													13	39					0	0	1	0	0
ACSL5	51703	broad.mit.edu	37	10	114136198	114136198	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:114136198C>T	ENST00000356116.1	+	1	243	c.131C>T	c.(130-132)cCc>cTc	p.P44L	ACSL5_ENST00000393081.1_Intron|ACSL5_ENST00000354655.4_Intron|ACSL5_ENST00000479936.1_Intron|ACSL5_ENST00000354273.4_5'UTR|ACSL5_ENST00000433418.1_5'UTR	NM_016234.3	NP_057318.2	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	0					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		GATGCGGCCCCCTCGCAGGGT	0.602000													16	11					0	0	1	0	0
NUAK2	81788	broad.mit.edu	37	1	205272820	205272820	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:205272820G>A	ENST00000367157.3	-	7	1771	c.1645C>T	c.(1645-1647)Ctg>Ttg	p.L549L		NM_030952.1	NP_112214.1	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	549					actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(3)|kidney(3)|large_intestine(4)|lung(4)|ovary(3)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	23	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			TCAGAGGACAGGATGCTGTCC	0.682000													29	33					0	0	1	0	0
FGD5	152273	broad.mit.edu	37	3	14861911	14861911	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:14861911G>A	ENST00000285046.5	+	1	1443	c.1333G>A	c.(1333-1335)Gga>Aga	p.G445R	FGD5_ENST00000543601.1_Missense_Mutation_p.G204R	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	445					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						CCCTGGAGAAGGAGGGCAGGC	0.622000													13	11					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80408655	80408655	+	Missense_Mutation	SNP	C	C	T	rs151071760		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:80408655C>T	ENST00000265080.4	+	14	2132	c.2065C>T	c.(2065-2067)Cct>Tct	p.P689S		NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	689	N-terminal Ras-GEF.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		ATACAAGAGGCCTTTCACCTC	0.493000													28	18					0	0	1	0	0
HID1	283987	broad.mit.edu	37	17	72950432	72950432	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:72950432G>A	ENST00000425042.2	-	14	1742	c.1665C>T	c.(1663-1665)atC>atT	p.I555I		NM_030630.2	NP_085133.1			HID1 domain containing																		TGCGCTTGCGGATGATGGCGT	0.677000													5	1					0	0	1	0	0
TMEM8C	389827	broad.mit.edu	37	9	136385356	136385356	+	Missense_Mutation	SNP	C	C	T	rs149158465	byFrequency	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:136385356C>T	ENST00000339996.3	-	2	291	c.190G>A	c.(190-192)Gac>Aac	p.D64N	TMEM8C_ENST00000413714.1_5'UTR	NM_001080483.2	NP_001073952.1	A6NI61	TMM8C_HUMAN	transmembrane protein 8C	64						integral to membrane				NS(1)|autonomic_ganglia(1)|large_intestine(2)|lung(4)	8						TCCAGGATGTCGTGACGCATG	0.577000													18	10					0	0	1	0	0
FBXO28	23219	broad.mit.edu	37	1	224345206	224345206	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:224345206G>T	ENST00000366862.5	+	5	908	c.865G>T	c.(865-867)Gtg>Ttg	p.V289L	FBXO28_ENST00000424254.2_3'UTR	NM_015176.3	NP_055991.1	Q9NVF7	FBX28_HUMAN	F-box protein 28	289										endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(2)|skin(1)	10	Breast(184;0.206)			GBM - Glioblastoma multiforme(131;0.0363)		TCGCACCAAAGTGCAAGAACA	0.478000													42	62					4.32679e-17	4.41568e-17	1	1	0
PCDHA8	56140	broad.mit.edu	37	5	140222038	140222038	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140222038G>A	ENST00000531613.1	+	1	1132	c.1132G>A	c.(1132-1134)Gat>Aat	p.D378N	PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.D378N	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAACGACCTCGATTCAGGTGC	0.522000													56	86					0	0	1	0	0
P4HTM	54681	broad.mit.edu	37	3	49038932	49038932	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:49038932G>A	ENST00000343546.4	+	3	866	c.498G>A	c.(496-498)aaG>aaA	p.K166K	P4HTM_ENST00000383729.4_Silent_p.K166K|P4HTM_ENST00000468374.1_3'UTR	NM_177938.2	NP_808807.2	Q9NXG6	P4HTM_HUMAN	prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)	166						endoplasmic reticulum membrane|integral to membrane	calcium ion binding|iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|kidney(1)|large_intestine(1)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	21					Vitamin C(DB00126)	CGCAGATGAAGGGGTTACAGC	0.572000													14	16					0	0	1	0	0
DPF3	8110	broad.mit.edu	37	14	73137905	73137905	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:73137905G>A	ENST00000541685.1	-	9	1025	c.1013C>T	c.(1012-1014)tCc>tTc	p.S338F	DPF3_ENST00000557704.1_5'UTR|DPF3_ENST00000556509.1_Intron|DPF3_ENST00000546183.1_Missense_Mutation_p.S348F	NM_012074.3	NP_036206.3	Q92784	DPF3_HUMAN	D4, zinc and double PHD fingers, family 3	169					chromatin modification|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nBAF complex	nucleic acid binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)	22				BRCA - Breast invasive adenocarcinoma(234;0.00649)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		TCCTCGACAGGAGCGAGGCTC	0.572000													16	17					0	0	1	0	0
FSTL5	56884	broad.mit.edu	37	4	162680617	162680617	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:162680617C>T	ENST00000306100.5	-	6	1109	c.673G>A	c.(673-675)Gat>Aat	p.D225N	FSTL5_ENST00000536695.1_Missense_Mutation_p.D224N|FSTL5_ENST00000379164.4_Missense_Mutation_p.D224N|FSTL5_ENST00000427802.2_Missense_Mutation_p.D224N	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	225	EF-hand 2.					extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		TTAAAATCATCATATTTCAAT	0.333000													14	25					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43930616	43930616	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:43930616C>T	ENST00000262726.7	-	30	4438	c.4185G>A	c.(4183-4185)aaG>aaA	p.K1395K	EFCAB6_ENST00000396231.2_Silent_p.K1243K|EFCAB6-AS1_ENST00000431327.2_RNA|EFCAB6_ENST00000461800.1_5'UTR	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	1395	Interaction with PARK7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				GTGAGCTTTCCTTTGCTTTTA	0.473000													24	34					0	0	1	0	0
IGHV3-43	28426	broad.mit.edu	37	14	106926339	106926339	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:106926339G>A	ENST00000434710.1	-	0	282																											ACTAATAAGAGAGACCCACTC	0.517000													45	105					0	0	1	0	0
DMRTC2	63946	broad.mit.edu	37	19	42354586	42354586	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:42354586C>T	ENST00000596827.1	+	7	1048	c.962C>T	c.(961-963)cCc>cTc	p.P321L	DMRTC2_ENST00000269945.3_Intron			Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	275	Pro-rich.				cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	10						TCTCCCTTTCCCTTGCAGGCC	0.607000													21	26					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92765048	92765048	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:92765048G>A	ENST00000318238.4	-	5	1453	c.237C>T	c.(235-237)tcC>tcT	p.S79S	SAMD9L_ENST00000437805.1_Silent_p.S79S|SAMD9L_ENST00000411955.1_Silent_p.S79S	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	79	SAM.									central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			CACTTTCAGGGGACTTACTAT	0.393000													34	57					0	0	1	0	0
TGFB2	7042	broad.mit.edu	37	1	218578520	218578520	+	Missense_Mutation	SNP	C	C	T	rs149533093		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:218578520C>T	ENST00000366929.4	+	3	907	c.440C>T	c.(439-441)cCg>cTg	p.P147L	TGFB2_ENST00000366930.4_Missense_Mutation_p.P119L	NM_001135599.2	NP_001129071.1	P61812	TGFB2_HUMAN	transforming growth factor, beta 2	119					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding			breast(1)|endometrium(1)|large_intestine(11)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(1)	31				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		GATGCCATCCCGCCCACTTTC	0.398000													50	101					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140590145	140590145	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140590145G>A	ENST00000239450.2	+	1	1855	c.1666G>A	c.(1666-1668)Gac>Aac	p.D556N	PCDHB12_ENST00000541609.1_Missense_Mutation_p.D219N	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		556	Cadherin 5.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding	p.D556N(1)		NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGACGCCAACGACAACTCGCC	0.711000													27	55					0	0	1	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64595920	64595920	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:64595920C>T	ENST00000536360.1	-	10	2075	c.1262G>A	c.(1261-1263)gGg>gAg	p.G421E				Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 6	421	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		ACCTTTCGTCCCACAAGAATT	0.393000													12	27					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103987	53103987	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:53103987G>A	ENST00000408890.4	+	1	639	c.623G>A	c.(622-624)cGg>cAg	p.R208Q		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	208										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						GGTGGCAGGCGGAACCTGCAG	0.667000													34	50					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130218616	130218616	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:130218616G>A	ENST00000276211.5	+	6	1110	c.765G>A	c.(763-765)ggG>ggA	p.G255G	ARHGAP36_ENST00000370922.1_Silent_p.G243G|ARHGAP36_ENST00000370921.1_Silent_p.G119G	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	255	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						GCGCAGTGGGGATTTTTACCC	0.488000													29	42					0	0	1	0	0
RTEL1	51750	broad.mit.edu	37	20	62328306	62328306	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:62328306C>T	ENST00000318100.4	+	36	4920	c.4093C>T	c.(4093-4095)Ccg>Tcg	p.P1365S	RTEL1-TNFRSF6B_ENST00000482936.1_Missense_Mutation_p.P1365S|TNFRSF6B_ENST00000369996.1_Silent_p.C62C			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	0					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			AGCGGCCGTGCCGCCGAGACA	0.682000													7	9					0	0	1	0	0
TRIM39	56658	broad.mit.edu	37	6	30309545	30309545	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:30309545C>T	ENST00000376659.5	+	8	1574	c.976C>T	c.(976-978)Cgt>Tgt	p.R326C	TRIM39_ENST00000540416.1_Missense_Mutation_p.R326C|TRIM39-RPP21_ENST00000513556.1_Missense_Mutation_p.R238C|TRIM39_ENST00000376656.4_Missense_Mutation_p.R356C|TRIM39_ENST00000396547.1_Missense_Mutation_p.R356C|TRIM39_ENST00000396548.1_Missense_Mutation_p.R326C|TRIM39_ENST00000396551.3_Missense_Mutation_p.R326C	NM_172016.2	NP_742013.1			tripartite motif containing 39											ovary(3)	3						GTCAGAGGATCGTAAGAGCGT	0.562000													18	19					0	0	1	0	0
GP1BA	2811	broad.mit.edu	37	17	4836052	4836052	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:4836052C>T	ENST00000329125.5	+	2	228	c.153C>T	c.(151-153)atC>atT	p.I51I		NM_000173.5	NP_000164.5	E7ES66	E7ES66_HUMAN	glycoprotein Ib (platelet), alpha polypeptide	51										central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(5)|stomach(1)|urinary_tract(1)	20						ACACAACCATCCTCCACCTGA	0.552000													39	25					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41306741	41306741	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:41306741C>T	ENST00000373198.3	-	7	1153	c.918G>A	c.(916-918)tgG>tgA	p.W306*	PTPRT_ENST00000373190.1_Nonsense_Mutation_p.W306*|PTPRT_ENST00000373193.3_Nonsense_Mutation_p.W306*|PTPRT_ENST00000356100.2_Nonsense_Mutation_p.W306*|PTPRT_ENST00000373184.1_Nonsense_Mutation_p.W306*|PTPRT_ENST00000373201.1_Nonsense_Mutation_p.W306*|PTPRT_ENST00000373187.1_Nonsense_Mutation_p.W306*	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	306	Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TTGGCTTGATCCACAGGTATG	0.547000													12	17					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43577114	43577114	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:43577114G>A	ENST00000452443.2	-	7	906	c.902C>T	c.(901-903)tCc>tTc	p.S301F		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	301					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	ACGGAAATTGGAAACAACACG	0.418000													14	31					0	0	1	0	0
EVPL	2125	broad.mit.edu	37	17	74004663	74004663	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:74004663C>T	ENST00000301607.3	-	22	4876	c.4623G>A	c.(4621-4623)gaG>gaA	p.E1541E	EVPL_ENST00000586740.1_Silent_p.E1563E	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	1541	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						TGTTGAGCATCTCCCACACGC	0.662000													10	30					0	0	1	0	0
LIMCH1	22998	broad.mit.edu	37	4	41684366	41684366	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:41684366G>A	ENST00000313860.7	+	21	2636	c.2582G>A	c.(2581-2583)gGa>gAa	p.G861E	LIMCH1_ENST00000512632.1_Missense_Mutation_p.G784E|LIMCH1_ENST00000509277.1_Missense_Mutation_p.G694E|LIMCH1_ENST00000381753.4_Missense_Mutation_p.G694E|LIMCH1_ENST00000511496.1_Missense_Mutation_p.G701E|LIMCH1_ENST00000514096.1_Missense_Mutation_p.G701E|LIMCH1_ENST00000512820.1_Missense_Mutation_p.G873E|LIMCH1_ENST00000503057.1_Missense_Mutation_p.G1245E|LIMCH1_ENST00000508501.1_Missense_Mutation_p.G860E|LIMCH1_ENST00000396595.3_Missense_Mutation_p.G706E|LIMCH1_ENST00000512946.1_Missense_Mutation_p.G861E|LIMCH1_ENST00000513024.1_Missense_Mutation_p.G714E	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	861					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						ATAGACCTGGGAAACTGTCAA	0.363000													3	15					0	0	1	0	0
BEGAIN	57596	broad.mit.edu	37	14	101010253	101010253	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:101010253G>A	ENST00000556751.1	-	3	3505	c.101C>T	c.(100-102)gCc>gTc	p.A34V	BEGAIN_ENST00000355173.2_Missense_Mutation_p.A98V|BEGAIN_ENST00000443071.2_Missense_Mutation_p.A98V			Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	98						cytoplasm|membrane	protein binding			cervix(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|stomach(1)	14		Melanoma(154;0.212)				GCTGTTGAGGGCAACAATCTC	0.617000													4	7					0	0	1	0	0
DLG2	1740	broad.mit.edu	37	11	83344332	83344332	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:83344332C>T	ENST00000398309.2	-	14	2017	c.1547G>A	c.(1546-1548)cGa>cAa	p.R516Q	DLG2_ENST00000531015.1_Missense_Mutation_p.R483Q|DLG2_ENST00000280241.8_Missense_Mutation_p.R555Q|DLG2_ENST00000398304.1_5'UTR|DLG2_ENST00000537455.1_Missense_Mutation_p.R270Q|DLG2_ENST00000330014.6_Missense_Mutation_p.R455Q|DLG2_ENST00000426717.2_5'UTR|DLG2_ENST00000543673.1_Missense_Mutation_p.R621Q|DLG2_ENST00000376104.2_Missense_Mutation_p.R621Q|DLG2_ENST00000530800.1_Missense_Mutation_p.R25Q|DLG2_ENST00000376106.3_5'UTR|DLG2_ENST00000404783.3_5'UTR|DLG2_ENST00000532653.1_Missense_Mutation_p.R516Q|DLG2_ENST00000524982.1_Missense_Mutation_p.R516Q|DLG2_ENST00000418306.2_Missense_Mutation_p.R413Q	NM_001364.3	NP_001355.2	Q15700	DLG2_HUMAN	discs, large homolog 2 (Drosophila)	516						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(11)|lung(35)|ovary(3)|pancreas(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	71		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				CATCTGCTCTCGTAGGTCATG	0.488000													14	21					0	0	1	0	0
FAM114A1	92689	broad.mit.edu	37	4	38907396	38907396	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:38907396C>T	ENST00000358869.2	+	6	747	c.571C>T	c.(571-573)Cag>Tag	p.Q191*	FAM114A1_ENST00000515037.1_5'UTR	NM_138389.2	NP_612398.2	Q8IWE2	NXP20_HUMAN	family with sequence similarity 114, member A1	191						cytoplasm				haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	20						AGCCACAGATCAGGGCCCTGC	0.483000													8	14					0	0	1	0	0
PHC1	1911	broad.mit.edu	37	12	9086545	9086545	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:9086545C>T	ENST00000433083.2	+	8	1988	c.1843C>T	c.(1843-1845)Cct>Tct	p.P615S	PHC1_ENST00000433847.2_3'UTR|PHC1_ENST00000544916.1_Missense_Mutation_p.P660S|PHC1_ENST00000543824.1_Missense_Mutation_p.P660S|PHC1_ENST00000536844.1_Missense_Mutation_p.P266S			P78364	PHC1_HUMAN	polyhomeotic homolog 1 (Drosophila)	660					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|large_intestine(8)|liver(2)|lung(3)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	27						TTCAATGCTTCCTGCCAAGGC	0.488000													4	15					0	0	1	0	0
GPRASP2	114928	broad.mit.edu	37	X	101970947	101970947	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:101970947G>A	ENST00000543253.1	+	5	2069	c.1150G>A	c.(1150-1152)Gaa>Aaa	p.E384K	GPRASP2_ENST00000332262.5_Missense_Mutation_p.E384K|GPRASP2_ENST00000535209.1_Missense_Mutation_p.E384K	NM_001004051.3|NM_001184874.2|NM_001184876.2	NP_001004051.1|NP_001171803.1|NP_001171805.1			G protein-coupled receptor associated sorting protein 2											breast(3)|endometrium(5)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	30						GTTTGAGGAGGAAGTCATTAT	0.502000													17	36					0	0	1	0	0
PSEN2	5664	broad.mit.edu	37	1	227077815	227077815	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:227077815C>T	ENST00000366782.1	+	9	1466	c.966C>T	c.(964-966)ttC>ttT	p.F322F	PSEN2_ENST00000391872.2_Silent_p.F322F|PSEN2_ENST00000472139.2_Silent_p.F145F|PSEN2_ENST00000422240.2_Silent_p.F289F|PSEN2_ENST00000340188.4_Intron|PSEN2_ENST00000366783.3_Silent_p.F289F			P49810	PSN2_HUMAN	presenilin 2 (Alzheimer disease 4)	289					amyloid precursor protein catabolic process|anti-apoptosis|apoptosis|beta-amyloid metabolic process|calcium ion transport|induction of apoptosis by extracellular signals|intracellular signal transduction|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear inner membrane|perinuclear region of cytoplasm|Z disc	aspartic-type endopeptidase activity|protein binding			cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|urinary_tract(1)	20		Prostate(94;0.0771)				AGCCCATATTCCCTGCCCTGA	0.592000													25	44					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	98205983	98205983	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:98205983C>T	ENST00000370192.3	-	4	386	c.286G>A	c.(286-288)Gat>Aat	p.D96N	DPYD_ENST00000306031.5_Missense_Mutation_p.D96N|DPYD_ENST00000423006.2_Missense_Mutation_p.D59N	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	96	4Fe-4S ferredoxin-type 1.				'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	GATTTAATATCAAGATTAGTT	0.323000													28	32					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29111179	29111179	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:29111179C>T	ENST00000261590.8	+	9	1453	c.1244C>T	c.(1243-1245)gCt>gTt	p.A415V		NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	415	Cadherin 4.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			AATTTTCAAGCTTTTGATGAG	0.358000													29	34					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111470984	111470984	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:111470984G>A	ENST00000265162.5	+	17	2785	c.2443G>A	c.(2443-2445)Gaa>Aaa	p.E815K		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	815					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	ATTAGCTCAAGAAAAAGAAAA	0.363000													16	19					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21239339	21239339	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:21239339T>A	ENST00000233242.1	-	21	3431	c.3304A>T	c.(3304-3306)Act>Tct	p.T1102S		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	1102					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCGACCTCAGTAATTTTCTTG	0.473000													12	7					0	0	1	0	0
OR3A4P	390756	broad.mit.edu	37	17	3214231	3214231	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:3214231G>A	ENST00000573491.1	-	0	359				OR3A4P_ENST00000323164.4_RNA																							CAGCTTTCATGGGTGTGGCCC	0.547000													28	10					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20248603	20248603	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:20248603G>A	ENST00000315957.4	+	1	203	c.122G>A	c.(121-123)gGa>gAa	p.G41E		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G41A(1)		NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATCCTACCAGGAAATATCCTT	0.423000													47	209					0	0	1	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105912892	105912892	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:105912892A>T	ENST00000393359.2	-	4	1385	c.959T>A	c.(958-960)cTt>cAt	p.L320H	TGFBRAP1_ENST00000258449.1_Missense_Mutation_p.L320H			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	320					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						GCTTGCTAGAAGATCCTGTAT	0.408000													19	11					0	0	1	0	0
HLA-G	3135	broad.mit.edu	37	6	29796368	29796368	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:29796368G>A	ENST00000428701.1	+	4	570	c.392G>A	c.(391-393)gGa>gAa	p.G131E	HLA-G_ENST00000376815.3_Intron|HLA-G_ENST00000376818.3_Intron|HLA-G_ENST00000360323.6_Missense_Mutation_p.G131E|HLA-G_ENST00000376828.2_Missense_Mutation_p.G136E	NM_002127.5	NP_002118.1	P17693	HLAG_HUMAN	major histocompatibility complex, class I, G	131	Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|cellular defense response|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(4)|ovary(3)|pancreas(1)|prostate(5)|skin(1)	21						GGGTCCGACGGACGCCTCCTC	0.682000													35	127					0	0	1	0	0
CNGA2	1260	broad.mit.edu	37	X	150911612	150911612	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:150911612G>A	ENST00000329903.4	+	6	670	c.637G>A	c.(637-639)Gac>Aac	p.D213N		NM_005140.1	NP_005131.1	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	213					response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(4)|endometrium(4)|large_intestine(5)|lung(34)|prostate(2)	49	Acute lymphoblastic leukemia(192;6.56e-05)					GAAACTGCGAGACAACTACAT	0.507000													13	28					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4512688	4512688	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:4512688G>A	ENST00000301286.3	-	3	1241	c.1242C>T	c.(1240-1242)atC>atT	p.I414I		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	414	27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						TACCTGTTGCGATATTTTGGG	0.557000													26	8					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52427426	52427426	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:52427426C>T	ENST00000420323.2	+	66	10812	c.10551C>T	c.(10549-10551)ctC>ctT	p.L3517L		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3582					ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GCCGCAGCCTCTTTGAGAAGC	0.532000													17	29					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24924229	24924229	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:24924229G>A	ENST00000329468.2	+	1	3689	c.3215G>A	c.(3214-3216)gGg>gAg	p.G1072E		NM_018958.2	NP_061831.2			nuclear pore associated protein 1									p.G1072E(1)									GCACCACAAGGGGCTAGCAAC	0.542000													24	38					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215814034	215814034	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:215814034G>A	ENST00000366943.2	-	68	15220	c.14834C>T	c.(14833-14835)tCt>tTt	p.S4945F	USH2A_ENST00000307340.3_Missense_Mutation_p.S4945F			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4945	Fibronectin type-III 35.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACACACCACAGACAAATTGCT	0.532000										HNSCC(13;0.011)			13	25					0	0	1	0	0
KNG1	3827	broad.mit.edu	37	3	186461545	186461545	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:186461545G>A	ENST00000287611.2	+	11	1522	c.1255G>A	c.(1255-1257)Gag>Aag	p.E419K	KNG1_ENST00000447445.1_Missense_Mutation_p.E383K|RP11-573D15.8_ENST00000599314.1_RNA|RP11-573D15.8_ENST00000596632.1_RNA|RP11-573D15.8_ENST00000596329.1_RNA|RP11-573D15.8_ENST00000354642.2_RNA	NM_000893.3	NP_000884.1	P01042	KNG1_HUMAN	kininogen 1	410					blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	GGCAGGGGCAGAGCCAGCATC	0.502000													14	11					0	0	1	0	0
TPH1	7166	broad.mit.edu	37	11	18050736	18050736	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:18050736C>T	ENST00000250018.2	-	5	1205	c.643G>A	c.(643-645)Gaa>Aaa	p.E215K	TPH1_ENST00000341556.2_Missense_Mutation_p.E215K	NM_004179.2	NP_004170.1	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	215					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(14)|prostate(1)|stomach(1)	25					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	GAGACATCTTCCAATTGTGGG	0.333000													29	42					0	0	1	0	0
OR11A1	26531	broad.mit.edu	37	6	29394885	29394885	+	Silent	SNP	A	A	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:29394885A>G	ENST00000377149.1	-	5	1006	c.534T>C	c.(532-534)ttT>ttC	p.F178F	OR5V1_ENST00000377154.1_Intron|OR11A1_ENST00000377147.2_Silent_p.F178F|OR11A1_ENST00000377148.1_Silent_p.F178F			Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A, member 1	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|large_intestine(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	19						AGTCACAGTAAAACTGGTCAA	0.532000													11	37					0	0	1	0	0
OR11H6	122748	broad.mit.edu	37	14	20692216	20692216	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:20692216C>T	ENST00000315519.2	+	1	426	c.348C>T	c.(346-348)ttC>ttT	p.F116F		NM_001004480.1	NP_001004480.1	Q8NGC7	O11H6_HUMAN	olfactory receptor, family 11, subfamily H, member 6	116					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(13)|ovary(2)|prostate(1)|skin(2)	29	all_cancers(95;0.00108)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0143)		CTGGTTGCTTCCTGCAATTCT	0.408000													32	52					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81176684	81176684	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:81176684C>T	ENST00000394685.3	+	7	1205	c.786C>T	c.(784-786)caC>caT	p.H262H	KIAA1199_ENST00000220244.3_Silent_p.H262H|KIAA1199_ENST00000356249.5_Silent_p.H262H			Q8WUJ3	K1199_HUMAN	KIAA1199	262										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						ACTTCCTGCACCTTGGATTTA	0.498000													18	13					0	0	1	0	0
MPP6	51678	broad.mit.edu	37	7	24703293	24703293	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:24703293G>T	ENST00000396475.2	+	7	1035	c.736G>T	c.(736-738)Gga>Tga	p.G246*	MPP6_ENST00000222644.4_Nonsense_Mutation_p.G246*|MPP6_ENST00000409761.1_Nonsense_Mutation_p.G134*	NM_016447.2	NP_057531.2	Q9NZW5	MPP6_HUMAN	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	246	SH3.				protein complex assembly		protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(7)|pancreas(1)|skin(2)	20						GTTTTCCAAAGGAGAGATTCT	0.343000													11	18					3.07112e-06	3.08757e-06	1	1	0
FGF10	2255	broad.mit.edu	37	5	44388621	44388621	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:44388621G>A	ENST00000264664.4	-	1	278	c.164C>T	c.(163-165)tCc>tTc	p.S55F		NM_004465.1	NP_004456.1	O15520	FGF10_HUMAN	fibroblast growth factor 10	55	Poly-Ser.				actin cytoskeleton reorganization|activation of MAPK activity|bud outgrowth involved in lung branching|ERK1 and ERK2 cascade|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|insulin receptor signaling pathway|lacrimal gland development|lung saccule development|mesonephros development|negative regulation of cell cycle arrest|positive regulation of ATPase activity|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of DNA repair|positive regulation of DNA replication|positive regulation of epithelial cell migration|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of ERK1 and ERK2 cascade|positive regulation of hair follicle cell proliferation|positive regulation of keratinocyte migration|positive regulation of keratinocyte proliferation|positive regulation of lymphocyte proliferation|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of Ras protein signal transduction|positive regulation of transcription, DNA-dependent|positive regulation of urothelial cell proliferation|protein localization at cell surface|radial glial cell differentiation|regulation of saliva secretion|response to protein stimulus|secretion by lung epithelial cell involved in lung growth|tear secretion|thymus development|urothelial cell proliferation	cell surface|extracellular space|nucleus|plasma membrane	chemoattractant activity|growth factor activity|heparin binding|type 2 fibroblast growth factor receptor binding			haematopoietic_and_lymphoid_tissue(1)|lung(11)|skin(1)	13	Lung NSC(6;1.12e-06)					GGAGAAGGAGGAGGAAGAAGA	0.537000													12	21					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228481963	228481963	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:228481963G>A	ENST00000570156.2	+	47	12603	c.12529G>A	c.(12529-12531)Ggg>Agg	p.G4177R	OBSCN_ENST00000359599.6_Missense_Mutation_p.G2595R|OBSCN_ENST00000422127.1_Missense_Mutation_p.G3748R|OBSCN_ENST00000284548.11_Missense_Mutation_p.G3748R|OBSCN_ENST00000366707.4_Missense_Mutation_p.G867R|OBSCN_ENST00000366709.4_Missense_Mutation_p.G867R	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	3220	Ig-like 43.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GTGGAGGAAGGGGCATGAGAC	0.627000													45	71					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10298675	10298675	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:10298675G>A	ENST00000403437.2	-	34	4831	c.4737C>T	c.(4735-4737)atC>atT	p.I1579I	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1579					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CCTTTTCTGCGATTTTTCTAT	0.418000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				17	7					0	0	1	0	0
XYLT1	64131	broad.mit.edu	37	16	17221574	17221574	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:17221574G>A	ENST00000261381.6	-	10	2256	c.2172C>T	c.(2170-2172)gtC>gtT	p.V724V		NM_022166.3	NP_071449.1	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	724					glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(7)|lung(35)|ovary(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CGATCTTGAAGACTTTTTTCG	0.493000													57	83					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114111074	114111074	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:114111074C>T	ENST00000297405.5	-	5	1072	c.828G>A	c.(826-828)ggG>ggA	p.G276G	CSMD3_ENST00000352409.3_Silent_p.G276G|CSMD3_ENST00000519485.1_5'UTR|CSMD3_ENST00000343508.3_Silent_p.G236G|CSMD3_ENST00000455883.2_Silent_p.G276G	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	276	CUB 2.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						AAATTGTGTCCCCAGGCTCTG	0.388000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			3	14					0	0	1	0	0
OR4Q3	441669	broad.mit.edu	37	14	20215586	20215586	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:20215586G>A	ENST00000331723.1	+	1	0		c.e1-1			NM_172194.1	NP_751944.1	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q, member 3						sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(4)|endometrium(3)|kidney(2)|large_intestine(1)|lung(28)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTCTTGGCTTGATGAAAAAAG	0.308000													15	42					0	0	1	0	0
RGAG4	340526	broad.mit.edu	37	X	71350022	71350022	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:71350022C>T	ENST00000545866.1	-	1	1736	c.1369G>A	c.(1369-1371)Gat>Aat	p.D457N	NHSL2_ENST00000540800.1_Intron|RGAG4_ENST00000479991.1_Missense_Mutation_p.D457N			Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	457										cervix(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|skin(1)	24	Renal(35;0.156)					TGGGCCTCATCCAGTGGCTCC	0.562000													32	45					0	0	1	0	0
CENPH	64946	broad.mit.edu	37	5	68504126	68504126	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:68504126C>T	ENST00000283006.2	+	8	678	c.591C>T	c.(589-591)atC>atT	p.I197I	CENPH_ENST00000515001.1_Silent_p.I178I	NM_022909.3	NP_075060.1	Q9H3R5	CENPH_HUMAN	centromere protein H	197					cell division|CenH3-containing nucleosome assembly at centromere|chromosome segregation|kinetochore organization|mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleoplasm	kinetochore binding|protein binding			kidney(15)|large_intestine(2)|lung(3)	20		Lung NSC(167;5.51e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;1.41e-56)|Epithelial(20;1.29e-52)|all cancers(19;3.15e-48)|Lung(70;0.0178)		GGATAAAGATCATACGACAAA	0.313000													15	22					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121787235	121787235	+	Missense_Mutation	SNP	G	G	A	rs142050826	by1000genomes	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:121787235G>A	ENST00000261367.7	+	12	4262	c.2834G>A	c.(2833-2835)gGg>gAg	p.G945E	CTC-210G5.1_ENST00000509993.1_RNA|CTC-210G5.1_ENST00000506053.1_RNA|SNCAIP_ENST00000379538.3_Missense_Mutation_p.G532E|CTC-210G5.1_ENST00000505546.1_RNA|CTC-210G5.1_ENST00000503529.1_RNA|SNCAIP_ENST00000379536.2_Missense_Mutation_p.G838E|CTC-210G5.1_ENST00000510972.1_RNA|SNCAIP_ENST00000414317.2_Missense_Mutation_p.G500E|SNCAIP_ENST00000503116.2_3'UTR|SNCAIP_ENST00000504884.2_3'UTR|SNCAIP_ENST00000542191.1_Missense_Mutation_p.G456E|SNCAIP_ENST00000261368.8_Missense_Mutation_p.G898E|SNCAIP_ENST00000379533.2_Missense_Mutation_p.G945E			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	898					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		ACCTCACTTGGGAGGAAGACA	0.438000													26	43					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2808668	2808668	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:2808668C>T	ENST00000520002.1	-	67	10727	c.10172G>A	c.(10171-10173)aGc>aAc	p.S3391N	CSMD1_ENST00000542608.1_Missense_Mutation_p.S3213N|CSMD1_ENST00000537824.1_Missense_Mutation_p.S3390N|CSMD1_ENST00000602723.1_Missense_Mutation_p.S3214N|CSMD1_ENST00000400186.3_Missense_Mutation_p.S3214N|CSMD1_ENST00000602557.1_Missense_Mutation_p.S3391N			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3391						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CGAGGCTTCGCTGAAGGTGGC	0.463000													4	7					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2566815	2566815	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:2566815A>T	ENST00000399655.1	+	5	965	c.700A>T	c.(700-702)Aag>Tag	p.K234*	CACNA1C_ENST00000402845.3_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000399634.1_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000347598.4_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000399591.1_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000399629.1_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000399601.1_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000399638.1_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000327702.7_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000399637.1_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000399649.1_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000344100.3_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000406454.3_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000399597.1_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000480911.1_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000399644.1_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000399641.1_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000399595.1_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000399603.1_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000399617.1_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000335762.5_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000399621.1_Nonsense_Mutation_p.K234*|CACNA1C_ENST00000399606.1_Nonsense_Mutation_p.K234*	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	234					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ATTTGATGTGAAGGCGCTGAG	0.547000													62	113					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152383387	152383387	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:152383387G>A	ENST00000271835.3	-	3	233	c.171C>T	c.(169-171)gtC>gtT	p.V57V	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	57	EF-hand.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCAGACGCAGGACCTCATCCA	0.537000													17	39					0	0	1	0	0
RNF152	220441	broad.mit.edu	37	18	59483414	59483414	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:59483414G>A	ENST00000312828.3	-	2	1382	c.283C>T	c.(283-285)Ccc>Tcc	p.P95S		NM_173557.2	NP_775828.1	Q8N8N0	RN152_HUMAN	ring finger protein 152	95					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)	17		Colorectal(73;0.186)				CCATTGCTGGGAAGTTTGATG	0.647000													25	29					0	0	1	0	0
ATOH1	474	broad.mit.edu	37	4	94750453	94750453	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:94750453G>A	ENST00000306011.3	+	1	412	c.376G>A	c.(376-378)Gaa>Aaa	p.E126K		NM_005172.1	NP_005163.1	Q92858	ATOH1_HUMAN	atonal homolog 1 (Drosophila)	126					transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	11		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		GAAAGTGCGGGAACAGCTGTG	0.687000													14	18					0	0	1	0	0
ZNF449	203523	broad.mit.edu	37	X	134483138	134483138	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:134483138C>T	ENST00000339249.4	+	3	598	c.458C>T	c.(457-459)cCt>cTt	p.P153L		NM_152695.5	NP_689908.3	Q6P9G9	ZN449_HUMAN	zinc finger protein 449	153					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					GTAATGGGACCTGCCCAGGAG	0.562000													52	71					0	0	1	0	0
ZFP37	7539	broad.mit.edu	37	9	115818916	115818916	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:115818916C>T	ENST00000374227.3	-	1	80	c.53G>A	c.(52-54)cGg>cAg	p.R18Q	ZFP37_ENST00000553380.1_Missense_Mutation_p.R18Q|ZFP37_ENST00000555206.1_Missense_Mutation_p.R18Q			Q9Y6Q3	ZFP37_HUMAN	ZFP37 zinc finger protein	18						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						ACTTCTCCTCCGGTCCACGGT	0.672000													46	21					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58580319	58580319	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:58580319C>T	ENST00000317147.5	-	29	4244	c.3912G>A	c.(3910-3912)aaG>aaA	p.K1304K	CNOT1_ENST00000569240.1_Silent_p.K1299K|CNOT1_ENST00000441024.2_Silent_p.K1304K|CNOT1_ENST00000245138.4_Silent_p.K155K	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1304					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GATCTTTATCCTTTAGGAGGT	0.423000													16	24					0	0	1	0	0
EBAG9	9166	broad.mit.edu	37	8	110567014	110567014	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:110567014C>T	ENST00000337573.5	+	4	519	c.219C>T	c.(217-219)atC>atT	p.I73I	EBAG9_ENST00000529502.1_3'UTR|EBAG9_ENST00000531677.1_Silent_p.I73I|EBAG9_ENST00000395785.2_Silent_p.I73I	NM_004215.3	NP_004206.1	O00559	RCAS1_HUMAN	estrogen receptor binding site associated, antigen, 9	73					apoptosis|regulation of cell growth	focal adhesion|Golgi membrane|integral to membrane|soluble fraction	apoptotic protease activator activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)	10			OV - Ovarian serous cystadenocarcinoma(57;1.39e-14)			GTGTAAAGATCGAAGGAGGGA	0.408000													19	21					0	0	1	0	0
PVRL4	81607	broad.mit.edu	37	1	161042564	161042564	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:161042564G>A	ENST00000368012.3	-	9	1722	c.1420C>T	c.(1420-1422)Cag>Tag	p.Q474*	PVRL4_ENST00000486694.1_5'UTR|PVRL4_ENST00000453926.2_Nonsense_Mutation_p.Q183*	NM_030916.2	NP_112178.2	Q96NY8	PVRL4_HUMAN	poliovirus receptor-related 4	474					adherens junction organization|cell adhesion|cell junction assembly	adherens junction|extracellular region|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|urinary_tract(1)	20	all_cancers(52;8.9e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00165)			CCTTCATCCTGATCTTCCTCC	0.582000													18	25					0	0	1	0	0
OR10A3	26496	broad.mit.edu	37	11	7960903	7960903	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:7960903G>A	ENST00000360759.3	-	1	238	c.165C>T	c.(163-165)ctC>ctT	p.L55L		NM_001003745.1	NP_001003745.1	P58181	O10A3_HUMAN	olfactory receptor, family 10, subfamily A, member 3	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)	21				Epithelial(150;1.38e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		TGGGAACGTGGAGGCTCTGGT	0.488000													21	32					0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26681952	26681952	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:26681952G>A	ENST00000256737.3	+	27	3759	c.2907G>A	c.(2905-2907)cgG>cgA	p.R969R	ANO3_ENST00000537978.1_Silent_p.R953R|ANO3_ENST00000531568.1_Silent_p.R823R|ANO3_ENST00000525139.1_Silent_p.R953R	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	969						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						AACAACAACGGAGAAAAAGTG	0.428000													21	31					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857077	9857077	+	Missense_Mutation	SNP	G	G	A	rs59975221		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:9857077G>A	ENST00000396573.2	-	14	4633	c.4324C>T	c.(4324-4326)Ccc>Tcc	p.P1442S	GRIN2A_ENST00000330684.3_Missense_Mutation_p.P1442S|GRIN2A_ENST00000396575.2_Missense_Mutation_p.P1442S|GRIN2A_ENST00000535259.1_3'UTR|GRIN2A_ENST00000562109.1_3'UTR|GRIN2A_ENST00000404927.2_3'UTR	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1442					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AAAACCCTGGGGGTAGAGTAC	0.398000													16	16					0	0	1	0	0
BNC1	646	broad.mit.edu	37	15	83932990	83932990	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:83932990G>A	ENST00000345382.2	-	4	1098	c.1013C>T	c.(1012-1014)tCc>tTc	p.S338F	RP11-382A20.4_ENST00000565495.1_RNA|BNC1_ENST00000569704.1_Missense_Mutation_p.S331F	NM_001717.3	NP_001708.3	Q01954	BNC1_HUMAN	basonuclin 1	338					epidermis development|positive regulation of cell proliferation	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|prostate(2)|skin(4)|urinary_tract(1)	56						GGCCTCAGGGGATAACTGTGT	0.453000													23	39					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140222414	140222414	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140222414C>T	ENST00000531613.1	+	1	1508	c.1508C>T	c.(1507-1509)tCg>tTg	p.S503L	PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.S503L	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGAGCGCTCGCTGTCGAGC	0.667000													46	59					0	0	1	0	0
HUWE1	10075	broad.mit.edu	37	X	53565956	53565956	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:53565956G>A	ENST00000342160.3	-	75	12175	c.11718C>T	c.(11716-11718)agC>agT	p.S3906S	HUWE1_ENST00000262854.6_Silent_p.S3906S			Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase	3906					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			NS(1)|breast(15)|central_nervous_system(1)|cervix(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|liver(2)|lung(52)|ovary(11)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(2)	153						GTGCCAGCTGGCTCTCACGGG	0.617000													13	6					0	0	1	0	0
SCAF1	58506	broad.mit.edu	37	19	50149388	50149388	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:50149388C>T	ENST00000360565.3	+	4	314	c.190C>T	c.(190-192)Cga>Tga	p.R64*		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	64					mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		TCATGGCCTTCGATGGCGGCG	0.617000													16	13					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10615110	10615110	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:10615110G>A	ENST00000547195.1	-	16	2331	c.1831C>T	c.(1831-1833)Cct>Tct	p.P611S	MRVI1-AS1_ENST00000529829.1_RNA|MRVI1_ENST00000421747.1_Missense_Mutation_p.P693S|MRVI1_ENST00000545852.1_Missense_Mutation_p.P387S|LYVE1_ENST00000531706.1_Intron|MRVI1_ENST00000424001.1_Missense_Mutation_p.P387S|MRVI1_ENST00000423302.2_Missense_Mutation_p.P702S|MRVI1_ENST00000558540.1_Missense_Mutation_p.P387S|MRVI1-AS1_ENST00000529979.1_RNA|MRVI1_ENST00000534266.2_Missense_Mutation_p.P387S|MRVI1_ENST00000541483.1_Missense_Mutation_p.P496S|MRVI1_ENST00000527509.2_Missense_Mutation_p.P611S|MRVI1-AS1_ENST00000525578.1_RNA|MRVI1_ENST00000552103.1_Missense_Mutation_p.P611S|MRVI1_ENST00000436272.1_Missense_Mutation_p.P675S|MRVI1_ENST00000531107.1_Missense_Mutation_p.P694S	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	675					platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		TTAAACTTAGGAACCACAGCA	0.527000													12	28					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179569951	179569951	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:179569951G>A	ENST00000589042.1	-	103	29778	c.29554C>T	c.(29554-29556)Caa>Taa	p.Q9852*	TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.Q9535*|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000342992.6_Nonsense_Mutation_p.Q8608*	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9535							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCAAATGCTTGAAGAAGACCT	0.363000													21	13					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15770030	15770030	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:15770030G>A	ENST00000221307.7	+	13	1446	c.1397_splice	c.e13-1	p.R466_splice	CYP4F3_ENST00000591058.1_Splice_Site_p.R466_splice|CYP4F3_ENST00000585846.1_Splice_Site_p.R466_splice|CYP4F3_ENST00000586182.1_Splice_Site_p.R466_splice	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	466					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						CCTCCCCAAGGAACTGCATCG	0.662000													5	14					0	0	1	0	0
SLC22A2	6582	broad.mit.edu	37	6	160663398	160663398	+	Missense_Mutation	SNP	C	C	T	rs141405449	byFrequency	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:160663398C>T	ENST00000366953.3	-	8	1574	c.1316G>A	c.(1315-1317)gGa>gAa	p.G439E	SLC22A2_ENST00000491092.1_5'UTR	NM_003058.3	NP_003049.2	O15244	S22A2_HUMAN	solute carrier family 22 (organic cation transporter), member 2	439					body fluid secretion|neurotransmitter biosynthetic process|neurotransmitter secretion	integral to plasma membrane|membrane fraction	neurotransmitter transporter activity|organic cation transmembrane transporter activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(16)|prostate(2)|skin(1)	27		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.28e-17)|BRCA - Breast invasive adenocarcinoma(81;6.29e-06)		CCCCATTCTTCCCAAGCATGA	0.428000													22	12					0	0	1	0	0
MAGEC3	139081	broad.mit.edu	37	X	140984599	140984599	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:140984599C>T	ENST00000544766.1	+	5	688	c.161C>T	c.(160-162)tCc>tTc	p.S54F	MAGEC3_ENST00000536088.1_Missense_Mutation_p.S54F|MAGEC3_ENST00000298296.1_Intron|MAGEC3_ENST00000483584.1_3'UTR|MAGEC3_ENST00000409007.1_Missense_Mutation_p.S54F|MAGEC3_ENST00000443323.2_Intron	NM_177456.2	NP_803251.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	448										NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					ttcccctcctcctcttccttg	0.517000													8	12					0	0	1	0	0
CFI	3426	broad.mit.edu	37	4	110673624	110673624	+	Splice_Site	SNP	C	C	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:110673624C>G	ENST00000394634.2	-	8	1147	c.940_splice	c.e8+1	p.E314_splice	CFI_ENST00000512148.1_Splice_Site_p.E307_splice|CFI_ENST00000394635.3_Splice_Site_p.E322_splice	NM_000204.3	NP_000195.2	P05156	CFAI_HUMAN	complement factor I	314					complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|skin(2)|stomach(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		GTTAGCTTACCTGCATCCATG	0.294000													17	17					0	0	1	0	0
RHAG	6005	broad.mit.edu	37	6	49604462	49604462	+	Missense_Mutation	SNP	A	A	T	rs139234886	byFrequency	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:49604462A>T	ENST00000371175.4	-	1	90	c.64T>A	c.(64-66)Tta>Ata	p.L22I	RHAG_ENST00000229810.7_Missense_Mutation_p.L22I	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	22					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					TCAACAAATAATCCAAATAAA	0.433000													27	51					0	0	1	0	0
NUGGC	389643	broad.mit.edu	37	8	27880861	27880861	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:27880861C>T	ENST00000413272.2	-	19	2506	c.2364G>A	c.(2362-2364)aaG>aaA	p.K788K	NUGGC_ENST00000341513.6_Silent_p.K788K	NM_001010906.1	NP_001010906.1			nuclear GTPase, germinal center associated																		GGGGGCCAGCCTTGCTGGGGG	0.532000													10	18					0	0	1	0	0
STARD10	10809	broad.mit.edu	37	11	72468891	72468891	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:72468891G>A	ENST00000334805.6	-	5	1417	c.498C>T	c.(496-498)tcC>tcT	p.S166S	STARD10_ENST00000543304.1_Silent_p.S166S|STARD10_ENST00000538536.1_Silent_p.S120S|STARD10_ENST00000545082.1_Silent_p.S137S|ARAP1_ENST00000359373.5_Intron|STARD10_ENST00000538437.1_Intron	NM_006645.2	NP_006636.2	Q9Y365	PCTL_HUMAN	StAR-related lipid transfer (START) domain containing 10	166	START.									endometrium(4)|large_intestine(1)|lung(2)|prostate(1)	8			BRCA - Breast invasive adenocarcinoma(5;7.08e-07)			CCGTCTGGATGGACACAGCTC	0.597000													14	25					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98608864	98608864	+	Silent	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:98608864T>C	ENST00000359863.4	+	70	11295	c.11086T>C	c.(11086-11088)Tta>Cta	p.L3696L	TRRAP_ENST00000446306.3_Silent_p.L3685L|TRRAP_ENST00000355540.3_Silent_p.L3667L	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	3696	PI3K/PI4K.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CCCCGAGATGTTACAGATCGC	0.493000													27	55					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12315498	12315498	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:12315498G>A	ENST00000256186.2	+	3	811	c.520G>A	c.(520-522)Gag>Aag	p.E174K		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	174					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		GCTGGTAAAGGAGAAGTTGGG	0.537000													24	24					0	0	1	0	0
HJURP	55355	broad.mit.edu	37	2	234750777	234750777	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:234750777G>A	ENST00000411486.2	-	8	714	c.649C>T	c.(649-651)Cct>Tct	p.P217S	HJURP_ENST00000441687.1_Missense_Mutation_p.P132S|HJURP_ENST00000432087.1_Missense_Mutation_p.P163S|HJURP_ENST00000434039.1_5'UTR	NM_018410.3	NP_060880.3	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	217					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			NS(2)|breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(2)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		GGATGCAAAGGATCCCATTCT	0.493000													23	9					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121008416	121008416	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:121008416C>T	ENST00000392793.1	+	11	3499	c.3228C>T	c.(3226-3228)ccC>ccT	p.P1076P	TECTA_ENST00000264037.2_Silent_p.P1076P			O75443	TECTA_HUMAN	tectorin alpha	1076					cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AGACCATTCCCTGCAAGGATG	0.572000													9	27					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182363373	182363373	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:182363373G>A	ENST00000397033.2	+	15	1994	c.1564G>A	c.(1564-1566)Gat>Aat	p.D522N		NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	522					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	CATGAGTTTGGATGTGAACAG	0.333000													19	7					0	0	1	0	0
FKBP6	8468	broad.mit.edu	37	7	72743439	72743439	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:72743439G>A	ENST00000252037.4	+	3	321	c.252G>A	c.(250-252)atG>atA	p.M84I	FKBP6_ENST00000413573.2_Intron|FKBP6_ENST00000431982.2_Missense_Mutation_p.M79I	NM_003602.3	NP_003593.3	O75344	FKBP6_HUMAN	FK506 binding protein 6, 36kDa	84	PPIase FKBP-type.				protein folding	membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)	16		Lung NSC(55;0.0908)|all_lung(88;0.198)				CTCGGCTAATGAAACTTGGAG	0.468000													27	39					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38881818	38881818	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:38881818C>T	ENST00000274276.3	+	4	772	c.370C>T	c.(370-372)Cct>Tct	p.P124S	OSMR_ENST00000502536.1_Missense_Mutation_p.P124S	NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	124					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					TGCCAAGTTCCCTGAGCCAAA	0.448000													12	26					0	0	1	0	0
JADE3	9767	broad.mit.edu	37	X	46918377	46918377	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:46918377G>A	ENST00000218343.4	+	11	2668	c.2370G>A	c.(2368-2370)agG>agA	p.R790R	PHF16_ENST00000397189.1_Silent_p.R790R	NM_014735.3	NP_055550.1	Q92613	JADE3_HUMAN		790					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(2)|endometrium(8)|kidney(4)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(2)	33						TCAGGGTAAGGAAAGATAGCT	0.458000													10	13					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167653129	167653129	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:167653129C>T	ENST00000519204.1	+	23	4900	c.4782C>T	c.(4780-4782)cgC>cgT	p.R1594R	TENM2_ENST00000403607.2_Silent_p.R1539R|TENM2_ENST00000518659.1_Silent_p.R1715R|TENM2_ENST00000545108.1_Silent_p.R1714R|TENM2_ENST00000520394.1_Silent_p.R1476R					teneurin transmembrane protein 2																		ACGTGACGCGCCCCACGGGGG	0.527000													5	9					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10348614	10348614	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:10348614C>T	ENST00000255381.2	-	36	5345	c.5235G>A	c.(5233-5235)atG>atA	p.M1745I	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1745					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CGATGTCCTCCATCTCTCCCT	0.463000													26	14					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73044609	73044609	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:73044609C>T	ENST00000604411.1	+	0	32570				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						CTAGCTCTTTCCTGGTTACCT	0.328000													17	13					0	0	1	0	0
P2RY10	27334	broad.mit.edu	37	X	78216491	78216491	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:78216491C>T	ENST00000171757.2	+	4	754	c.474C>T	c.(472-474)atC>atT	p.I158I	P2RY10_ENST00000544091.1_Silent_p.I158I|P2RY10_ENST00000475374.1_3'UTR	NM_014499.2	NP_055314.1	O00398	P2Y10_HUMAN	purinergic receptor P2Y, G-protein coupled, 10	158						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.I158I(1)		breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(22)|ovary(3)|skin(2)	42						CCATCTGGATCGTTGTGGGGA	0.493000													30	33					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123847037	123847037	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:123847037C>T	ENST00000369005.1	+	4	5362	c.5022C>T	c.(5020-5022)gcC>gcT	p.A1674A	TACC2_ENST00000453444.2_Silent_p.A1674A|TACC2_ENST00000513429.1_Intron|TACC2_ENST00000515273.1_Silent_p.A1674A|TACC2_ENST00000358010.1_Intron|TACC2_ENST00000515603.1_Silent_p.A1674A|TACC2_ENST00000334433.3_Silent_p.A1674A	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	1674						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				TGCGAAATGCCCTGGGCAACC	0.622000													15	5					0	0	1	0	0
SLC45A1	50651	broad.mit.edu	37	1	8384477	8384477	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:8384477G>A	ENST00000471889.1	+	2	473	c.88G>A	c.(88-90)Ggc>Agc	p.G30S	SLC45A1_ENST00000377479.2_Missense_Mutation_p.G64S|SLC45A1_ENST00000289877.8_Missense_Mutation_p.G30S			Q9Y2W3	S45A1_HUMAN	solute carrier family 45, member 1	30					carbohydrate transport	integral to membrane	symporter activity			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(2)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(2)	33	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;1.22e-15)|all_lung(118;0.000147)|Lung NSC(185;0.000251)|Renal(390;0.000469)|Colorectal(325;0.00578)|Breast(348;0.00686)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.11)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;3.95e-66)|GBM - Glioblastoma multiforme(8;5.93e-33)|Colorectal(212;2.86e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|Kidney(185;5.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000513)|KIRC - Kidney renal clear cell carcinoma(229;0.000979)|STAD - Stomach adenocarcinoma(132;0.00199)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGGTCACGGGCTACTCGGG	0.667000													39	49					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115411593	115411593	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:115411593C>T	ENST00000369358.4	-	7	888	c.644G>A	c.(643-645)cGg>cAg	p.R215Q	NRAP_ENST00000360478.3_Missense_Mutation_p.R215Q|NRAP_ENST00000359988.3_Missense_Mutation_p.R215Q|NRAP_ENST00000369360.3_Missense_Mutation_p.R215Q			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	215						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		AGCCTTGCTCCGTAGCAGCTC	0.517000													10	8					0	0	1	0	0
ELN	2006	broad.mit.edu	37	7	73483000	73483000	+	Silent	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:73483000G>T	ENST00000252034.7	+	33	2544	c.2145G>T	c.(2143-2145)ctG>ctT	p.L715L	ELN_ENST00000357036.5_Silent_p.L702L|ELN_ENST00000458204.1_Silent_p.L705L|ELN_ENST00000429192.1_Silent_p.L683L|ELN_ENST00000380576.5_Silent_p.L696L|ELN_ENST00000414324.1_Silent_p.L691L|ELN_ENST00000380553.4_Silent_p.L561L|ELN_ENST00000380575.4_Silent_p.L668L|ELN_ENST00000358929.4_Silent_p.L783L|ELN_ENST00000320492.7_Silent_p.L634L|ELN_ENST00000320399.6_Silent_p.L748L|ELN_ENST00000380562.4_Silent_p.L721L|ELN_ENST00000380584.4_Silent_p.L649L|ELN_ENST00000445912.1_Silent_p.L697L	NM_000501.2	NP_000492.2	P15502	ELN_HUMAN	elastin	777	Ala-rich.				blood circulation|cell proliferation|organ morphogenesis|respiratory gaseous exchange	proteinaceous extracellular matrix	extracellular matrix constituent conferring elasticity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(10)|ovary(4)|pancreas(2)|prostate(1)|skin(2)|stomach(1)	32		Lung NSC(55;0.159)			Rofecoxib(DB00533)	GGGCCTGCCTGGGGAAAGCTT	0.582000			T	PAX5	B-ALL		"""Supravalvular Aortic Stenosis, Cutis laxa , Williams-Beuren Syndrome"""						18	31					5.35267e-07	5.39097e-07	1	1	0
TTN	7273	broad.mit.edu	37	2	179615216	179615216	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:179615216G>A	ENST00000360870.5	-	46	12133	c.11911C>T	c.(11911-11913)Cct>Tct	p.P3971S	TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9787							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATAGGTTGAGGATATCCTTGA	0.358000													12	6					0	0	1	0	0
PRRC2C	23215	broad.mit.edu	37	1	171540486	171540486	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:171540486C>T	ENST00000367742.3	+	24	6921	c.6679C>T	c.(6679-6681)Cct>Tct	p.P2227S	PRRC2C_ENST00000426496.2_Intron|PRRC2C_ENST00000338920.4_Missense_Mutation_p.P2225S|PRRC2C_ENST00000392078.3_Missense_Mutation_p.P2227S			Q9Y520	PRC2C_HUMAN	proline-rich coiled-coil 2C	2225							protein C-terminus binding										CCTTCCCCTCCCTAAGAGGGA	0.468000													8	16					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32698994	32698994	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:32698994G>A	ENST00000380250.3	+	7	1194	c.698G>A	c.(697-699)gGa>gAa	p.G233E		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	233					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GAAGTCATTGGAGTGTTGGCA	0.473000													32	78					0	0	1	0	0
TMEM45A	55076	broad.mit.edu	37	3	100277365	100277365	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:100277365C>T	ENST00000403410.1	+	6	1188	c.568C>T	c.(568-570)Cgg>Tgg	p.R190W	TMEM45A_ENST00000323523.4_Missense_Mutation_p.R174W			Q9NWC5	TM45A_HUMAN	transmembrane protein 45A	174						integral to membrane				breast(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|skin(2)	11						GTTCCTTGTTCGGAACAATGT	0.512000													47	65					0	0	1	0	0
HSD17B7P2	158160	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													5	21					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8518223	8518223	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:8518223C>T	ENST00000381196.4	-	18	1711	c.1168G>A	c.(1168-1170)Gaa>Aaa	p.E390K	PTPRD_ENST00000486161.1_Missense_Mutation_p.E390K|PTPRD_ENST00000397606.3_Missense_Mutation_p.E380K|PTPRD_ENST00000540109.1_Missense_Mutation_p.E390K|PTPRD_ENST00000358503.5_Missense_Mutation_p.E377K|PTPRD_ENST00000355233.5_Missense_Mutation_p.E390K|PTPRD_ENST00000356435.5_Missense_Mutation_p.E390K|PTPRD_ENST00000397611.3_Missense_Mutation_p.E387K|PTPRD_ENST00000397617.3_Missense_Mutation_p.E380K|PTPRD_ENST00000537002.1_Missense_Mutation_p.E387K|PTPRD_ENST00000360074.4_Missense_Mutation_p.E377K	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	390	Fibronectin type-III 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ACCCTGAATTCATAATCCGAG	0.507000										TSP Lung(15;0.13)			34	56					0	0	1	0	0
SLC29A4	222962	broad.mit.edu	37	7	5327602	5327602	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:5327602C>T	ENST00000396872.2	+	2	316	c.155C>T	c.(154-156)gCt>gTt	p.A52V	SLC29A4_ENST00000297195.4_Missense_Mutation_p.A52V|SLC29A4_ENST00000406453.3_Missense_Mutation_p.A52V	NM_001040661.1|NM_153247.2	NP_001035751.1|NP_694979.2	Q7RTT9	S29A4_HUMAN	solute carrier family 29 (equilibrative nucleoside transporter), member 4	52					nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|integral to membrane	nucleoside transmembrane transporter activity			breast(1)|cervix(2)|kidney(7)|large_intestine(1)|liver(1)|lung(7)|urinary_tract(1)	20		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0903)|OV - Ovarian serous cystadenocarcinoma(56;2.65e-15)		GGCGTCCCAGCTTTCACGGAT	0.657000													7	11					0	0	1	0	0
KRT76	51350	broad.mit.edu	37	12	53164796	53164796	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:53164796C>T	ENST00000332411.2	-	7	1524	c.1471G>A	c.(1471-1473)Gga>Aga	p.G491R		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	491	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						CACTCCTCTCCCTCCAGCAGC	0.542000													26	59					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175362997	175362997	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:175362997C>T	ENST00000367674.1	-	6	1983	c.1275G>A	c.(1273-1275)acG>acA	p.T425T	TNR_ENST00000263525.2_Silent_p.T425T	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	425	Fibronectin type-III 2.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix		p.T425T(1)		NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TCTCTGTGATCGTCTTAAATT	0.498000													46	70					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141740594	141740594	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:141740594C>T	ENST00000475668.2	+	21	2500	c.2446C>T	c.(2446-2448)Cga>Tga	p.R816*	MGAM_ENST00000549489.2_Nonsense_Mutation_p.R816*			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	816	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	ACTTCACCTTCGAGGAGGCTA	0.468000													13	23					0	0	1	0	0
SLC7A13	157724	broad.mit.edu	37	8	87241946	87241946	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:87241946C>T	ENST00000297524.3	-	1	664	c.561G>A	c.(559-561)aaG>aaA	p.K187K	SLC7A13_ENST00000419776.2_Silent_p.K187K|SLC7A13_ENST00000520624.1_Intron	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	187						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						CTACATTCTCCTTTTTCCCTC	0.408000													21	39					0	0	1	0	0
KRT76	51350	broad.mit.edu	37	12	53170633	53170633	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:53170633G>A	ENST00000332411.2	-	1	496	c.443C>T	c.(442-444)cCt>cTt	p.P148L		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	148	Head.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AAAGCCCCCAGGGCCAAAGcc	0.582000													13	16					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80655845	80655845	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:80655845G>A	ENST00000458043.2	+	18	1965	c.1959G>A	c.(1957-1959)gtG>gtA	p.V653V	OTOGL_ENST00000547103.1_Silent_p.V653V	NM_173591.3	NP_775862.3			otogelin-like									p.V653V(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						TCCCAGTGGTGGACCCCTGTA	0.393000													13	30					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78598741	78598741	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:78598741A>T	ENST00000397909.2	+	39	7034	c.6861A>T	c.(6859-6861)gaA>gaT	p.E2287D	NAV3_ENST00000536525.2_Missense_Mutation_p.E2265D|NAV3_ENST00000228327.6_Missense_Mutation_p.E2265D|NAV3_ENST00000266692.7_Missense_Mutation_p.E2088D|NAV3_ENST00000541270.1_Missense_Mutation_p.E117D			Q8IVL0	NAV3_HUMAN	neuron navigator 3	2287						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CACCATGGGAAGATCCTTCAA	0.463000										HNSCC(70;0.22)			11	13					0	0	1	0	0
SNAP25	6616	broad.mit.edu	37	20	10280055	10280055	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:10280055G>A	ENST00000254976.2	+	7	758	c.547G>A	c.(547-549)Gag>Aag	p.E183K	SNAP25_ENST00000304886.2_Missense_Mutation_p.E183K|SNAP25-AS1_ENST00000453544.1_RNA|SNAP25_ENST00000495883.1_3'UTR|SNAP25-AS1_ENST00000421143.2_RNA	NM_130811.2	NP_570824.1	P60880	SNP25_HUMAN	synaptosomal-associated protein, 25kDa	183	t-SNARE coiled-coil homology 2.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				endometrium(1)|large_intestine(2)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	18					Botulinum Toxin Type A(DB00083)	CAGGATCATGGAGAAGGTGAG	0.522000													18	17					0	0	1	0	0
WWC3	55841	broad.mit.edu	37	X	10046892	10046892	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:10046892G>A	ENST00000380861.4	+	4	665	c.274G>A	c.(274-276)Gaa>Aaa	p.E92K	WWC3_ENST00000454666.1_Missense_Mutation_p.E92K	NM_015691.3	NP_056506.2	Q9ULE0	WWC3_HUMAN	WWC family member 3	92										NS(1)|breast(3)|endometrium(10)|kidney(1)|large_intestine(11)|lung(17)|ovary(5)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	52						AATTAAAGCAGAAATAGCAAG	0.393000													39	58					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215848702	215848702	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:215848702T>A	ENST00000366943.2	-	63	12937	c.12551A>T	c.(12550-12552)aAa>aTa	p.K4184I	USH2A_ENST00000307340.3_Missense_Mutation_p.K4184I			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4184	Fibronectin type-III 27.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GCGAATTATTTTTCCATTTGG	0.473000										HNSCC(13;0.011)			28	28					0	0	1	0	0
PRAMEF10	343071	broad.mit.edu	37	1	12955399	12955399	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:12955399G>A	ENST00000235347.4	-	2	359	c.280C>T	c.(280-282)Cgc>Tgc	p.R94C		NM_001039361.3	NP_001034450.2	O60809	PRA10_HUMAN	PRAME family member 10	94										NS(2)|breast(1)|large_intestine(2)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	12	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.00224)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CACCTGGGGCGAACCTTCTGG	0.607000													10	16					0	0	1	0	0
C6orf10	10665	broad.mit.edu	37	6	32334079	32334079	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:32334079C>T	ENST00000375015.4	-	5	367	c.166_splice	c.e5-1	p.G56_splice	C6orf10_ENST00000375007.4_Splice_Site_p.G56_splice|C6orf10_ENST00000447241.2_Splice_Site_p.G56_splice|C6orf10_ENST00000442822.2_Splice_Site_p.G56_splice|C6orf10_ENST00000527965.1_Splice_Site_p.G56_splice|C6orf10_ENST00000533191.1_Splice_Site_p.G56_splice			Q5SRN2	CF010_HUMAN	chromosome 6 open reading frame 10	56						integral to membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	25						ATGTCGGGATCCTAAAAGAGA	0.264000													13	31					0	0	1	0	0
EIF4H	7458	broad.mit.edu	37	7	73604023	73604023	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:73604023G>A	ENST00000265753.8	+	3	407	c.268G>A	c.(268-270)Gat>Aat	p.D90N	EIF4H_ENST00000353999.6_Missense_Mutation_p.D90N|EIF4H_ENST00000495187.1_3'UTR	NM_022170.1	NP_071496.1	Q15056	IF4H_HUMAN	eukaryotic translation initiation factor 4H	90	RRM.				interspecies interaction between organisms|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex|perinuclear region of cytoplasm	nucleotide binding|protein binding|translation initiation factor activity			endometrium(1)|lung(2)|prostate(1)	4						TGTAGAATTCGATGAAGTGGA	0.403000													14	21					0	0	1	0	0
AVIL	10677	broad.mit.edu	37	12	58197441	58197441	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:58197441C>T	ENST00000537081.1	-	14	1661	c.1662G>A	c.(1660-1662)ggG>ggA	p.G554G	TSFM_ENST00000548851.1_Intron|AVIL_ENST00000550083.1_Intron|AVIL_ENST00000257861.3_Silent_p.G561G			O75366	AVIL_HUMAN	advillin	561	Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(6)	32	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					CCCGCTCATCCCCACTAGACC	0.572000											OREG0021955	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	12					0	0	1	0	0
EIF4G1	1981	broad.mit.edu	37	3	184041252	184041252	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:184041252C>T	ENST00000342981.4	+	14	2562	c.2148C>T	c.(2146-2148)atC>atT	p.I716I	EIF4G1_ENST00000427845.1_Silent_p.I629I|EIF4G1_ENST00000414031.1_Silent_p.I675I|EIF4G1_ENST00000441154.1_Silent_p.I552I|EIF4G1_ENST00000346169.2_Silent_p.I715I|EIF4G1_ENST00000350481.5_Silent_p.I551I|EIF4G1_ENST00000352767.3_Silent_p.I722I|EIF4G1_ENST00000411531.1_Silent_p.I676I|EIF4G1_ENST00000434061.2_Silent_p.I520I|EIF4G1_ENST00000424196.1_Silent_p.I722I|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000382330.3_Silent_p.I722I|EIF4G1_ENST00000319274.6_Silent_p.I715I|EIF4G1_ENST00000435046.2_Silent_p.I519I|EIF4G1_ENST00000392537.2_Silent_p.I628I	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	715	MIF4G.|eIF3/EIF4A-binding.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CACGCAAGATCATTGCCACAG	0.547000													51	94					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135430098	135430098	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:135430098G>A	ENST00000394143.1	+	6	4524	c.4233G>A	c.(4231-4233)caG>caA	p.Q1411Q	GPR112_ENST00000287534.4_Silent_p.Q1348Q|GPR112_ENST00000412101.1_Silent_p.Q1206Q|GPR112_ENST00000370652.1_Silent_p.Q1411Q|GPR112_ENST00000394141.1_Silent_p.Q1206Q	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1411					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CATATGGCCAGGATACTTCAT	0.423000													44	54					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82447616	82447616	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:82447616C>T	ENST00000370728.1	+	21	3871	c.3226C>T	c.(3226-3228)Cag>Tag	p.Q1076*	LPHN2_ENST00000394879.1_Nonsense_Mutation_p.Q1078*|LPHN2_ENST00000335786.5_Nonsense_Mutation_p.Q1076*|LPHN2_ENST00000370717.2_Nonsense_Mutation_p.Q1091*|LPHN2_ENST00000370725.1_Nonsense_Mutation_p.Q1091*|LPHN2_ENST00000370715.1_Nonsense_Mutation_p.Q1063*|LPHN2_ENST00000370730.1_Nonsense_Mutation_p.Q1076*|LPHN2_ENST00000319517.6_Nonsense_Mutation_p.Q1063*|LPHN2_ENST00000370721.1_Nonsense_Mutation_p.Q1001*|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370727.1_Nonsense_Mutation_p.Q1091*|LPHN2_ENST00000370713.1_Nonsense_Mutation_p.Q1063*|LPHN2_ENST00000370723.1_Nonsense_Mutation_p.Q1078*|LPHN2_ENST00000359929.3_Nonsense_Mutation_p.Q1063*|LPHN2_ENST00000271029.4_Nonsense_Mutation_p.Q1091*			O95490	LPHN2_HUMAN	latrophilin 2	1076					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TAATGCTTTCCAGGGAGTGTT	0.378000													22	40					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168105113	168105113	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:168105113C>T	ENST00000409195.1	+	9	7300	c.7211C>T	c.(7210-7212)tCt>tTt	p.S2404F	XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.S2404F|XIRP2_ENST00000409273.1_Missense_Mutation_p.S2182F|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2229					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GCCTCGAACTCTCAGAATTCT	0.443000													24	4					0	0	1	0	0
COL4A6	1288	broad.mit.edu	37	X	107417843	107417843	+	Nonsense_Mutation	SNP	C	C	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:107417843C>A	ENST00000394872.2	-	31	3199	c.2968G>T	c.(2968-2970)Gga>Tga	p.G990*	COL4A6_ENST00000545689.1_Nonsense_Mutation_p.G989*|COL4A6_ENST00000538570.1_Nonsense_Mutation_p.G989*|COL4A6_ENST00000334504.7_Nonsense_Mutation_p.G989*|COL4A6_ENST00000372216.4_Nonsense_Mutation_p.G990*			Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	990	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						CCAGCCTCTCCTTTGTCACCT	0.542000									Alport syndrome with Diffuse Leiomyomatosis				6	23					0.00198382	0.00198735	1	1	0
COL27A1	85301	broad.mit.edu	37	9	117027741	117027741	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:117027741C>T	ENST00000356083.3	+	32	3770	c.3379C>T	c.(3379-3381)Ctc>Ttc	p.L1127F		NM_032888.2	NP_116277.2	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1	1127	Collagen-like 9.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(30)|ovary(4)|prostate(6)|skin(3)|soft_tissue(1)|stomach(1)|urinary_tract(3)	80						CACCAAGGGCCTCCCAGGAGA	0.612000													7	8					0	0	1	0	0
LYPLAL1	127018	broad.mit.edu	37	1	219347257	219347257	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:219347257C>T	ENST00000366928.5	+	1	72	c.25C>T	c.(25-27)Ctg>Ttg	p.L9L	RP11-135J2.4_ENST00000441331.1_RNA|LYPLAL1_ENST00000483635.1_3'UTR|LYPLAL1_ENST00000366927.3_Silent_p.L9L	NM_138794.3	NP_620149.1	Q5VWZ2	LYPL1_HUMAN	lysophospholipase-like 1	9						cytoplasm	lysophospholipase activity			large_intestine(1)|lung(5)	6				GBM - Glioblastoma multiforme(131;0.055)|all cancers(67;0.105)|OV - Ovarian serous cystadenocarcinoma(81;0.116)		GGGGTCGGTTCTGCAGCGCTG	0.627000													9	27					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48388901	48388901	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:48388901C>T	ENST00000224600.4	-	1	2090	c.1977G>A	c.(1975-1977)caG>caA	p.Q659Q		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	659	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GGGCACTGGTCTGCCCCACGA	0.672000													16	9					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42174878	42174878	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:42174878C>T	ENST00000320955.6	-	10	2178	c.1951G>A	c.(1951-1953)Gag>Aag	p.E651K		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	651					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CAGGCTTCCTCCTCCTCACAG	0.662000													9	3					0	0	1	0	0
SLC5A1	6523	broad.mit.edu	37	22	32480931	32480931	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:32480931G>A	ENST00000266088.4	+	9	1180	c.930G>A	c.(928-930)gtG>gtA	p.V310V	SLC5A1_ENST00000543737.1_Silent_p.V183V	NM_000343.3	NP_000334.1	P13866	SC5A1_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 1	310					carbohydrate metabolic process	integral to plasma membrane	glucose:sodium symporter activity|protein binding			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(1)|prostate(2)|skin(4)|urinary_tract(1)	37						TGTCTCACGTGAAGGGTGGCT	0.512000													26	40					0	0	1	0	0
PYROXD2	84795	broad.mit.edu	37	10	100152776	100152776	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:100152776G>A	ENST00000370575.4	-	9	898	c.850C>T	c.(850-852)Cag>Tag	p.Q284*	PYROXD2_ENST00000483923.1_5'UTR	NM_032709.2	NP_116098.2	Q8N2H3	PYRD2_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 2	284							oxidoreductase activity			central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	12						ATGCCCCCCTGGACGTAGCCC	0.617000													35	11					0	0	1	0	0
STAT6	6778	broad.mit.edu	37	12	57490531	57490531	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:57490531T>A	ENST00000300134.3	-	22	2693	c.2368A>T	c.(2368-2370)Ata>Tta	p.I790L	STAT6_ENST00000543873.2_Missense_Mutation_p.I790L|STAT6_ENST00000538913.2_Missense_Mutation_p.I680L|STAT6_ENST00000537215.2_Missense_Mutation_p.I680L|STAT6_ENST00000556155.1_Missense_Mutation_p.I790L|STAT6_ENST00000454075.3_Missense_Mutation_p.I790L	NM_001178078.1|NM_003153.4	NP_001171549.1|NP_003144.3	P42226	STAT6_HUMAN	signal transducer and activator of transcription 6, interleukin-4 induced	790					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(2)|lung(8)|ovary(4)|skin(1)	28						GGAGGGAATATGTCTTCACCA	0.617000													11	14					0	0	1	0	0
SEZ6L	23544	broad.mit.edu	37	22	26688779	26688779	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:26688779G>A	ENST00000529632.2	+	2	698	c.502G>A	c.(502-504)Ggg>Agg	p.G168R	SEZ6L_ENST00000343706.4_Missense_Mutation_p.G168R|SEZ6L_ENST00000248933.6_Missense_Mutation_p.G168R|SEZ6L_ENST00000404234.3_Missense_Mutation_p.G168R|SEZ6L_ENST00000360929.3_Missense_Mutation_p.G168R|SEZ6L_ENST00000402979.1_5'UTR|SEZ6L_ENST00000403121.1_5'UTR	NM_001184774.1|NM_001184775.1|NM_001184777.1	NP_001171703.1|NP_001171704.1|NP_001171706.1	Q9BYH1	SE6L1_HUMAN	seizure related 6 homolog (mouse)-like	168						endoplasmic reticulum membrane|integral to membrane				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(35)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	80						TGGCCCACCGGGGGACCCGGA	0.672000													26	33					0	0	1	0	0
ZC3H12C	85463	broad.mit.edu	37	11	110036356	110036356	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:110036356T>C	ENST00000453089.2	+	5	3334	c.2453T>C	c.(2452-2454)tTc>tCc	p.F818S	ZC3H12C_ENST00000278590.3_Missense_Mutation_p.F849S|ZC3H12C_ENST00000528673.1_Missense_Mutation_p.F850S			Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	849							endonuclease activity|nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(16)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		TGCAACATCTTCCCCCCTGAC	0.512000													3	2					0	0	1	0	0
ZNF223	7766	broad.mit.edu	37	19	44531259	44531259	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:44531259C>G	ENST00000591793.1	+	2	210	c.127C>G	c.(127-129)Cga>Gga	p.R43G	ZNF222_ENST00000587846.1_Missense_Mutation_p.R43G|ZNF222_ENST00000187879.8_Missense_Mutation_p.R34G|ZNF222_ENST00000391960.3_Missense_Mutation_p.R43G|ZNF222_ENST00000590160.1_3'UTR			Q9UK11	ZN223_HUMAN	zinc finger protein 223	34	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18		Prostate(69;0.0352)				GAAGCTGTACCGAGATGTGAT	0.552000													50	86					0	0	1	0	0
PSPC1	55269	broad.mit.edu	37	13	20277425	20277425	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:20277425G>A	ENST00000338910.4	-	9	1621	c.1462C>T	c.(1462-1464)Cct>Tct	p.P488S		NM_001042414.2	NP_001035879.1	Q8WXF1	PSPC1_HUMAN	paraspeckle component 1	488	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleolus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23		all_cancers(29;1.25e-22)|all_lung(29;1.97e-20)|all_epithelial(30;2.29e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;4.63e-06)|Epithelial(112;2.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00256)|Lung(94;0.00975)|LUSC - Lung squamous cell carcinoma(192;0.0483)		GGTGCTTGAGGGGTTTCAGAA	0.493000													12	44					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800849	185800849	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:185800849G>A	ENST00000302277.6	+	4	1320	c.726G>A	c.(724-726)gtG>gtA	p.V242V		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	242						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						ATGCCTCAGTGGGAAAAGGAT	0.428000													28	21					0	0	1	0	0
CD248	57124	broad.mit.edu	37	11	66082536	66082536	+	Silent	SNP	A	A	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:66082536A>G	ENST00000311330.3	-	1	1979	c.1963T>C	c.(1963-1965)Ttg>Ctg	p.L655L	RP11-867G23.13_ENST00000534065.1_RNA	NM_020404.2	NP_065137.1	Q9HCU0	CD248_HUMAN	CD248 molecule, endosialin	655	Pro-rich.					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	26					Cefalotin(DB00456)	CACAGGGCCAACTTGGGACTG	0.642000													18	22					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37730434	37730434	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:37730434G>A	ENST00000330843.4	-	4	1898	c.1886C>T	c.(1885-1887)cCc>cTc	p.P629L	RAB11FIP1_ENST00000287263.4_Intron|RAB11FIP1_ENST00000524118.1_Intron|RAB11FIP1_ENST00000522727.1_Intron|RAB11FIP1_ENST00000523182.1_5'UTR	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	629					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			AGGGAGCAAGGGTGGTCCTTC	0.512000													22	38					0	0	1	0	0
SPPL2C	162540	broad.mit.edu	37	17	43923097	43923097	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:43923097C>T	ENST00000329196.5	+	1	842	c.825C>T	c.(823-825)gaC>gaT	p.D275D	MAPT-AS1_ENST00000579599.1_RNA|MAPT-AS1_ENST00000579244.1_RNA	NM_175882.2	NP_787078.2	Q8IUH8	IMP5_HUMAN	signal peptide peptidase like 2C	275						integral to membrane	aspartic-type endopeptidase activity										TCTTCTATGACCACTTTGTCT	0.572000													36	90					0	0	1	0	0
LILRA5	353514	broad.mit.edu	37	19	54822799	54822799	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:54822799G>A	ENST00000301219.3	-	5	716	c.597C>T	c.(595-597)ttC>ttT	p.F199F	LILRA5_ENST00000446712.3_Silent_p.F187F|LILRA5_ENST00000432233.3_Silent_p.F199F|AC008984.2_ENST00000507363.1_RNA|LILRA5_ENST00000346508.3_Silent_p.F187F	NM_021250.2	NP_067073.1	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	199	Ig-like C2-type 2.				innate immune response	extracellular region|integral to membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGCCCACAGGGAACAGGGCCT	0.587000													22	31					0	0	1	0	0
SYN1	6853	broad.mit.edu	37	X	47466581	47466581	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:47466581C>T	ENST00000295987.7	-	2	518	c.394G>A	c.(394-396)Ggg>Agg	p.G132R	SYN1_ENST00000340666.4_Missense_Mutation_p.G132R	NM_006950.3	NP_008881.2	P17600	SYN1_HUMAN	synapsin I	132	C; actin-binding and synaptic-vesicle binding.					cell junction|Golgi apparatus	actin binding|ATP binding|ligase activity|transporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(6)|lung(6)|ovary(1)	21						ATCTTTTTCCCTTTGAAGTAT	0.438000													9	34					0	0	1	0	0
NACA2	342538	broad.mit.edu	37	17	59668385	59668385	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:59668385G>A	ENST00000521764.1	-	1	178	c.157C>T	c.(157-159)Ctg>Ttg	p.L53L		NM_199290.3	NP_954984.1	Q9H009	NACA2_HUMAN	nascent polypeptide-associated complex alpha subunit 2	53					protein transport	cytoplasm|nucleus				large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	12	all_epithelial(1;3.12e-14)					GCTGCCACCAGCCAGGCTTTT	0.507000													31	82					0	0	1	0	0
TNFRSF18	8784	broad.mit.edu	37	1	1140775	1140775	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:1140775G>A	ENST00000379268.2	-	2	404	c.285C>T	c.(283-285)ccC>ccT	p.P95P	TNFRSF18_ENST00000379265.5_Silent_p.P95P|TNFRSF18_ENST00000328596.6_Silent_p.P95P|TNFRSF18_ENST00000486728.1_Silent_p.P23P	NM_004195.2|NM_148902.1	NP_004186.1|NP_683700.1	Q9Y5U5	TNR18_HUMAN	tumor necrosis factor receptor superfamily, member 18	95					anti-apoptosis|apoptosis	extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			lung(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CCTGGCCTGGGGGACAAGGGT	0.657000													11	8					0	0	1	0	0
PELO	53918	broad.mit.edu	37	5	52096927	52096927	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:52096927C>T	ENST00000274311.2	+	2	1684	c.699C>T	c.(697-699)ctC>ctT	p.L233L	PELO_ENST00000506949.1_Intron|ITGA1_ENST00000504086.1_Intron|ITGA1_ENST00000282588.6_Intron	NM_015946.4	NP_057030.3	Q9BRX2	PELO_HUMAN	pelota homolog (Drosophila)	233					cell cycle|cell division|translation	cytoplasm|nucleus	endonuclease activity|metal ion binding|protein binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	11		Lung NSC(810;4.94e-05)|Breast(144;0.0848)				ACAAACTGCTCCTGGAAAACC	0.443000													10	25					0	0	1	0	0
CACNG5	27091	broad.mit.edu	37	17	64880766	64880766	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:64880766C>T	ENST00000533854.1	+	5	795	c.558C>T	c.(556-558)ttC>ttT	p.F186F	CACNG5_ENST00000307139.3_Silent_p.F186F|CACNG5_ENST00000169565.3_Silent_p.F186F			Q9UF02	CCG5_HUMAN	calcium channel, voltage-dependent, gamma subunit 5	186					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|postsynaptic density|postsynaptic membrane	voltage-gated calcium channel activity			NS(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	24			BRCA - Breast invasive adenocarcinoma(6;1.61e-08)			CCATCTCCTTCCTTTTAACGG	0.562000													29	41					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237972324	237972324	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:237972324G>A	ENST00000366574.2	+	100	14739	c.14422G>A	c.(14422-14424)Gat>Aat	p.D4808N	RYR2_ENST00000542537.1_Missense_Mutation_p.D4792N|RYR2_ENST00000360064.6_Missense_Mutation_p.D4814N	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	4808					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.D4806Y(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAAATGTGACGATATGCTAAC	0.338000													27	54					0	0	1	0	0
LACRT	90070	broad.mit.edu	37	12	55028623	55028623	+	Translation_Start_Site	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:55028623C>T	ENST00000257867.4	-	1	56	c.3G>A	c.(1-3)atG>atA	p.M1I	LACRT_ENST00000547511.1_Start_Codon_SNP_p.M1I	NM_033277.1	NP_150593.1	Q9GZZ8	LACRT_HUMAN	lacritin	1					calcineurin-NFAT signaling pathway|positive regulation of epithelial cell proliferation|positive regulation of NFAT protein import into nucleus|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of secretion|protein localization in Golgi apparatus|tear secretion	extracellular region|stored secretory granule	collagen binding|fibronectin binding|glycoprotein binding|growth factor activity|laminin-1 binding|protein N-terminus binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(4)|stomach(1)	10						TGGTAAATTTCATTCTTTGGG	0.512000													16	22					0	0	1	0	0
NCAN	1463	broad.mit.edu	37	19	19359523	19359523	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:19359523C>T	ENST00000252575.5	+	14	3695	c.3652C>T	c.(3652-3654)Cct>Tct	p.P1218S	NCAN_ENST00000538881.1_Missense_Mutation_p.P669S	NM_004386.2	NP_004377.2	O14594	NCAN_HUMAN	neurocan	1218	Sushi.				axon guidance|cell adhesion	extracellular region	calcium ion binding|hyaluronic acid binding|sugar binding			breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(32)|ovary(5)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64			Epithelial(12;0.00544)			CTGTGGTCCCCCTCCGGCAGT	0.517000													11	12					0	0	1	0	0
CCDC87	55231	broad.mit.edu	37	11	66358364	66358364	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:66358364T>C	ENST00000333861.3	-	1	2190	c.2123A>G	c.(2122-2124)aAa>aGa	p.K708R		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	708										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						CAGGCGGGCTTTGGAGCTATA	0.547000													32	52					0	0	1	0	0
CBX6	23466	broad.mit.edu	37	22	39262795	39262795	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:39262795G>A	ENST00000407418.3	-	5	781	c.658C>T	c.(658-660)Ctg>Ttg	p.L220L	CBX6_ENST00000216083.6_Silent_p.L202L			O95503	CBX6_HUMAN	chromobox homolog 6	220					chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	PcG protein complex				large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6	Melanoma(58;0.04)					TGTGTACGCAGGACGCTCTCG	0.706000													17	83					0	0	1	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5203839	5203839	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:5203839G>A	ENST00000334314.3	-	3	434	c.358C>T	c.(358-360)Cat>Tat	p.H120Y						aldo-keto reductase family 1, member C-like 1											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6						AATGGTACATGAATAATGAAG	0.413000													10	11					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102304772	102304772	+	RNA	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:102304772T>C	ENST00000561463.1	+	0	12818																											CACAGCGGCGTGACGAGACTC	0.587000													3	20					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9055492	9055492	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:9055492G>A	ENST00000383836.3	-	16	2275	c.1848C>T	c.(1846-1848)atC>atT	p.I616I	SRGAP3_ENST00000360413.3_Silent_p.I592I	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	616	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		GGATTTGTTGGATCTGGTGCA	0.527000			T	RAF1	pilocytic astrocytoma								18	30					0	0	1	0	0
TFR2	7036	broad.mit.edu	37	7	100238392	100238392	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:100238392G>A	ENST00000462107.1	-	4	677	c.390C>T	c.(388-390)ttC>ttT	p.F130F	TFR2_ENST00000431692.1_Silent_p.F130F|TFR2_ENST00000223051.3_Silent_p.F130F			Q9UP52	TFR2_HUMAN	transferrin receptor 2	130					cellular iron ion homeostasis|iron ion transport|proteolysis	cytoplasm|integral to plasma membrane	peptidase activity|transferrin receptor activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	23	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					TGCCCTGGTGGAAATCCAGGT	0.622000													15	19					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58299281	58299281	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:58299281C>T	ENST00000377918.3	+	4	3359	c.3333C>T	c.(3331-3333)tcC>tcT	p.S1111S		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	1111					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GCCGGGATTCCAGTGAGATGG	0.522000													140	79					0	0	1	0	0
PPFIA1	8500	broad.mit.edu	37	11	70208401	70208401	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:70208401T>C	ENST00000253925.7	+	21	2887	c.2672T>C	c.(2671-2673)gTt>gCt	p.V891A	PPFIA1_ENST00000389547.3_Missense_Mutation_p.V891A|AP000487.6_ENST00000528607.1_RNA	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	891	SAM 1.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			CAGCTCTGGGTTGGGATGCCA	0.562000													14	22					0	0	1	0	0
ABCA2	20	broad.mit.edu	37	9	139907180	139907180	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:139907180G>A	ENST00000265662.5	-	31	5212	c.5065C>T	c.(5065-5067)Cgc>Tgc	p.R1689C	ABCA2_ENST00000371605.3_Missense_Mutation_p.R1688C|ABCA2_ENST00000341511.6_Missense_Mutation_p.R1689C			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1688					cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		AGTCGGAAGCGGTCGGAGGTG	0.662000													9	7					0	0	1	0	0
AMELX	265	broad.mit.edu	37	X	11316866	11316866	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:11316866C>T	ENST00000380712.3	+	6	453	c.385C>T	c.(385-387)Cac>Tac	p.H129Y	ARHGAP6_ENST00000380718.1_Intron|ARHGAP6_ENST00000380732.3_Intron|ARHGAP6_ENST00000337414.4_Intron|ARHGAP6_ENST00000413512.3_Intron|AMELX_ENST00000348912.4_Missense_Mutation_p.H99Y|ARHGAP6_ENST00000380736.1_Intron|AMELX_ENST00000380714.3_Missense_Mutation_p.H115Y	NM_182680.1	NP_872621.1	Q99217	AMELX_HUMAN	amelogenin, X-linked	115					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel			endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	15						AATCCAACACCACCAGCCAAA	0.642000													32	48					0	0	1	0	0
KIF3A	11127	broad.mit.edu	37	5	132056301	132056301	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:132056301G>A	ENST00000378746.4	-	5	834	c.616_splice	c.e5+1	p.R206_splice	KIF3A_ENST00000403231.1_Splice_Site_p.R206_splice|KIF3A_ENST00000378735.1_Splice_Site_p.R206_splice|AC004237.1_ENST00000431165.1_RNA	NM_007054.5	NP_008985.3	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	206	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding	p.R206C(2)		endometrium(1)|kidney(4)|large_intestine(8)|lung(3)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	25		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTATACTTACGATTTTTGTGG	0.363000													4	5					0	0	1	0	0
KIF1C	10749	broad.mit.edu	37	17	4927035	4927035	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:4927035C>T	ENST00000320785.5	+	23	3258	c.2901C>T	c.(2899-2901)gcC>gcT	p.A967A		NM_006612.5	NP_006603.2	O43896	KIF1C_HUMAN	kinesin family member 1C	967	Pro-rich.				microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			NS(2)|breast(4)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|skin(1)|urinary_tract(3)	30						GGCCCCCAGCCCGCTTTGTGC	0.697000													19	6					0	0	1	0	0
GRM4	2914	broad.mit.edu	37	6	34101229	34101229	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:34101229G>A	ENST00000374181.3	-	1	214	c.45C>T	c.(43-45)ccC>ccT	p.P15P	GRM4_ENST00000374177.3_Intron|GRM4_ENST00000538487.1_Silent_p.P15P	NM_001256810.1	NP_001243739.1	Q14833	GRM4_HUMAN	glutamate receptor, metabotropic 4	15					activation of MAPK activity|inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway|neuroprotection|neurotransmitter secretion|positive regulation of MAPKKK cascade	cytoplasmic vesicle|integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(9)|liver(1)|lung(19)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48					L-Glutamic Acid(DB00142)	GCAGGCAAAGGGGCAGCCGGG	0.627000													7	38					0	0	1	0	0
ZFR	51663	broad.mit.edu	37	5	32415079	32415079	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:32415079T>C	ENST00000265069.8	-	5	881	c.779A>G	c.(778-780)tAt>tGt	p.Y260C		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	260	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		CTTACCAGAATATGTAACTGC	0.403000													21	24					0	0	1	0	0
OR52A4P	390053	broad.mit.edu	37	11	5142675	5142675	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:5142675C>T	ENST00000498233.1	-	0	723																				breast(1)|endometrium(2)|kidney(1)|lung(12)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		TAGAGAATTTCCAATCAGAGC	0.433000													25	41					0	0	1	0	0
OR6C6	283365	broad.mit.edu	37	12	55688902	55688902	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:55688902C>T	ENST00000358433.2	-	1	114	c.115G>A	c.(115-117)Ggg>Agg	p.G39R		NM_001005493.1	NP_001005493.1	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C, member 6	39					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						ATTAAGTTCCCCATCAGGCTC	0.413000													13	22					0	0	1	0	0
TAF1	6872	broad.mit.edu	37	X	70641224	70641224	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:70641224G>A	ENST00000449580.1	+	29	4498	c.4447G>A	c.(4447-4449)Gag>Aag	p.E1483K	TAF1_ENST00000423759.1_Missense_Mutation_p.E1504K|TAF1_ENST00000276072.3_Missense_Mutation_p.E1504K|TAF1_ENST00000373790.4_Missense_Mutation_p.E1483K			P21675	TAF1_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa	1483	Interaction with ASF1A and ASF1B.|Protein kinase 2.				G1 phase of mitotic cell cycle|interspecies interaction between organisms|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription initiation from RNA polymerase II promoter|protein autophosphorylation|regulation of transcription involved in G2/M-phase of mitotic cell cycle|RNA polymerase II transcriptional preinitiation complex assembly|transcription elongation from RNA polymerase II promoter|viral reproduction	MLL1 complex|transcription factor TFIID complex	ATP binding|histone acetyl-lysine binding|histone acetyltransferase activity|p53 binding|protein binding|protein serine/threonine kinase activity|sequence-specific DNA binding|TBP-class protein binding|transcription coactivator activity			breast(13)|central_nervous_system(6)|cervix(1)|endometrium(25)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(16)|lung(34)|ovary(9)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	124	Renal(35;0.156)	all_lung(315;0.000321)				AAAACTCAAAGAGGTAAGACA	0.403000													8	15					0	0	1	0	0
EMILIN2	84034	broad.mit.edu	37	18	2891020	2891020	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:2891020G>A	ENST00000254528.3	+	4	1054	c.895G>A	c.(895-897)Gaa>Aaa	p.E299K		NM_032048.2	NP_114437.2	Q9BXX0	EMIL2_HUMAN	elastin microfibril interfacer 2	299					cell adhesion	collagen	extracellular matrix constituent conferring elasticity|protein binding			breast(2)|endometrium(5)|kidney(3)|large_intestine(8)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(4)	48				READ - Rectum adenocarcinoma(2;0.1)		ACAGCTCCAGGAAGCAGCTCA	0.522000													29	49					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38924655	38924655	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:38924655G>A	ENST00000274276.3	+	14	2404	c.2002G>A	c.(2002-2004)Gcg>Acg	p.A668T		NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	668	Fibronectin type-III 4.				cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					GAAATCCAAGGCGAGGCAGTG	0.373000													25	40					0	0	1	0	0
OR2G3	81469	broad.mit.edu	37	1	247769190	247769190	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:247769190C>T	ENST00000320002.2	+	1	335	c.303C>T	c.(301-303)ctC>ctT	p.L101L	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TGGCGCAACTCTATATTTCTC	0.483000													56	100					0	0	1	0	0
RNF17	56163	broad.mit.edu	37	13	25338370	25338370	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:25338370C>T	ENST00000255324.5	+	1	81	c.29C>T	c.(28-30)cCt>cTt	p.P10L	RNF17_ENST00000255326.4_3'UTR|RNF17_ENST00000255325.5_Missense_Mutation_p.P10L|RNF17_ENST00000381921.1_Missense_Mutation_p.P10L	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	10					multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		AAGACTGGGCCTTCTAGGTCT	0.607000													21	74					0	0	1	0	0
LALBA	3906	broad.mit.edu	37	12	48962944	48962944	+	Silent	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:48962944G>T	ENST00000549817.1	-	2	258	c.213C>A	c.(211-213)ctC>ctA	p.L71L	LALBA_ENST00000301046.2_Silent_p.L71L			P00709	LALBA_HUMAN	lactalbumin, alpha-	71					cell-cell signaling|defense response to bacterium|induction of apoptosis|lactose biosynthetic process|signal transduction	extracellular space	calcium ion binding|lactose synthase activity			large_intestine(1)|stomach(2)	3						TGATCTGGAAGAGTCCATATT	0.453000													22	32					1.50039e-11	1.52019e-11	1	1	0
NPTXR	23467	broad.mit.edu	37	22	39218804	39218804	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:39218804G>A	ENST00000333039.2	-	5	1436	c.1313C>T	c.(1312-1314)gCc>gTc	p.A438V		NM_014293.3	NP_055108.2	O95502	NPTXR_HUMAN	neuronal pentraxin receptor	438	Pentaxin.					integral to membrane	metal ion binding			central_nervous_system(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	Melanoma(58;0.04)					ACCGACAAAGGCCTGGGTGGC	0.607000													7	30					0	0	1	0	0
DDX20	11218	broad.mit.edu	37	1	112303645	112303645	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:112303645C>T	ENST00000369702.4	+	6	1480	c.860C>T	c.(859-861)cCt>cTt	p.P287L	DDX20_ENST00000536167.1_3'UTR|DDX20_ENST00000475700.1_5'UTR	NM_007204.4	NP_009135.4	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	287					assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			endometrium(3)|kidney(7)|large_intestine(6)|lung(3)|pancreas(1)|prostate(1)	21		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AATTCATACCCTTTGGCACAT	0.343000													14	35					0	0	1	0	0
GPRC6A	222545	broad.mit.edu	37	6	117127687	117127687	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:117127687C>T	ENST00000310357.3	-	3	1202	c.1181G>A	c.(1180-1182)aGg>aAg	p.R394K	GPRC6A_ENST00000368549.3_Missense_Mutation_p.R394K|GPRC6A_ENST00000530250.1_Intron	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	394					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		GACGAAGTTCCTTTCTATAGC	0.438000													9	1					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8418476	8418476	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:8418476G>A	ENST00000337907.3	-	21	4753	c.4119C>T	c.(4117-4119)ccC>ccT	p.P1373P	RERE_ENST00000476556.1_Silent_p.P819P|RERE_ENST00000400907.2_Intron|RERE_ENST00000377464.1_Silent_p.P1105P|RERE_ENST00000400908.2_Silent_p.P1373P	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	1373					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CCCTCTCCAAGGGGTTCAGGC	0.692000													3	11					0	0	1	0	0
SFRP1	6422	broad.mit.edu	37	8	41122809	41122809	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:41122809C>T	ENST00000220772.3	-	3	1159	c.822G>A	c.(820-822)aaG>aaA	p.K274K	SFRP1_ENST00000379845.3_Silent_p.K138K	NM_003012.4	NP_003003.3	Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1	274	NTR.				brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|liver(1)|lung(1)|skin(1)	7	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			GGCTCTTCACCTTGCGGCCCA	0.507000													26	34					0	0	1	0	0
FAM120C	54954	broad.mit.edu	37	X	54143144	54143144	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:54143144G>A	ENST00000375180.2	-	10	2202	c.2146C>T	c.(2146-2148)Cgg>Tgg	p.R716W	FAM120C_ENST00000328235.4_Missense_Mutation_p.R716W	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	716										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						GTCCATTCCCGAAATGTCAGT	0.493000													14	19					0	0	1	0	0
IGHV4-34	28395	broad.mit.edu	37	14	106829627	106829627	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:106829627G>A	ENST00000390616.2	-	0	366																											TGTCCGCGGCGGTCACAGAGC	0.572000													75	127					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128540237	128540237	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:128540237C>T	ENST00000368227.3	-	6	1064	c.698G>A	c.(697-699)cGa>cAa	p.R233Q	PTPRK_ENST00000368213.5_Missense_Mutation_p.R233Q|PTPRK_ENST00000368226.4_Missense_Mutation_p.R233Q|PTPRK_ENST00000368207.3_Missense_Mutation_p.R233Q|PTPRK_ENST00000368210.3_Missense_Mutation_p.R233Q|PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368215.3_Missense_Mutation_p.R233Q|PTPRK_ENST00000532331.1_Missense_Mutation_p.R233Q			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	233	Ig-like C2-type.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TTCTCCATTTCGTCTCTGCAA	0.353000													20	7					0	0	1	0	0
PLXNC1	10154	broad.mit.edu	37	12	94697658	94697658	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:94697658A>C	ENST00000258526.4	+	29	4762	c.4513A>C	c.(4513-4515)Act>Cct	p.T1505P	PLXNC1_ENST00000545312.1_Missense_Mutation_p.T244P|PLXNC1_ENST00000547057.1_Missense_Mutation_p.T552P	NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	1505					axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						AGAATTTTTAACTCAGGAATC	0.333000													11	16					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109684123	109684123	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:109684123C>T	ENST00000338432.7	+	39	5560	c.5441C>T	c.(5440-5442)tCc>tTc	p.S1814F	ACACB_ENST00000377848.3_Missense_Mutation_p.S1814F|ACACB_ENST00000543201.1_Missense_Mutation_p.S480F|ACACB_ENST00000377854.5_Missense_Mutation_p.S1744F			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1814	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	CTGCGGGCATCCGAGATGGCC	0.567000													26	34					0	0	1	0	0
LRIF1	55791	broad.mit.edu	37	1	111494201	111494201	+	Silent	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:111494201A>T	ENST00000369763.4	-	2	1695	c.1305T>A	c.(1303-1305)gcT>gcA	p.A435A	LRIF1_ENST00000494675.1_Intron|LRIF1_ENST00000485275.2_Intron|RP11-96K19.2_ENST00000440689.1_RNA	NM_018372.3	NP_060842.3	Q5T3J3	LRIF1_HUMAN	ligand dependent nuclear receptor interacting factor 1	435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear matrix	protein binding			endometrium(2)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(1)|urinary_tract(2)	28						TGGCCATGGAAGCAAGCTGGG	0.393000													40	62					0	0	1	0	0
ARC	23237	broad.mit.edu	37	8	143694449	143694449	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:143694449G>A	ENST00000356613.2	-	1	2384	c.1184C>T	c.(1183-1185)cCc>cTc	p.P395L		NM_015193.3	NP_056008.1	Q7LC44	ARC_HUMAN	activity-regulated cytoskeleton-associated protein	395					endocytosis	acrosomal vesicle|cell junction|dendritic spine|endosome|postsynaptic density|postsynaptic membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	13	all_cancers(97;3.55e-12)|all_epithelial(106;1.03e-08)|Lung NSC(106;0.000353)|all_lung(105;0.00092)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.0279)				CCTCTACTCGGGCTGGGTCCG	0.706000													2	2					0	0	1	0	0
OR5AC2	81050	broad.mit.edu	37	3	97806256	97806256	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:97806256C>T	ENST00000358642.2	+	1	240	c.240C>T	c.(238-240)acC>acT	p.T80T		NM_054106.1	NP_473447.1	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC, member 2	80					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|large_intestine(3)|lung(13)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	28						CCTCTATAACCCCTAGGATGC	0.413000													49	82					0	0	1	0	0
OR10H2	26538	broad.mit.edu	37	19	15839075	15839075	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:15839075C>T	ENST00000305899.3	+	1	242	c.222C>T	c.(220-222)acC>acT	p.T74T		NM_013939.2	NP_039227.1	O60403	O10H2_HUMAN	olfactory receptor, family 10, subfamily H, member 2	74					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(1)	27	all_hematologic(1;0.0517)|Acute lymphoblastic leukemia(2;0.074)					TCCTCTACACCGTGGCCATCA	0.622000													37	55					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21611424	21611424	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:21611424G>A	ENST00000328843.6	+	8	1457	c.1425_splice	c.e8-1	p.D476_splice	DNAH11_ENST00000409508.3_Splice_Site_p.D476_splice			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	476	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TTTTACAAAGGATATATTTGC	0.338000									Kartagener syndrome				3	9					0	0	1	0	0
TLR8	51311	broad.mit.edu	37	X	12937325	12937325	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:12937325G>A	ENST00000218032.6	+	2	253	c.166G>A	c.(166-168)Gaa>Aaa	p.E56K	TLR8_ENST00000311912.5_Missense_Mutation_p.E74K	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	56					cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TCGACTACAGGAAGTTCCCCA	0.403000													20	61					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27688144	27688144	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:27688144G>A	ENST00000438700.3	-	4	1500	c.1383C>T	c.(1381-1383)atC>atT	p.I461I		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	461	SSD.				spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						CAGAAATCATGATAAACATGT	0.358000													9	6					0	0	1	0	0
FZR1	51343	broad.mit.edu	37	19	3527037	3527037	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:3527037C>T	ENST00000441788.2	+	6	683	c.447C>T	c.(445-447)tcC>tcT	p.S149S	FZR1_ENST00000313639.8_Intron|FZR1_ENST00000395095.3_Silent_p.S149S	NM_016263.3	NP_057347.2	Q9UM11	FZR_HUMAN	fizzy/cell division cycle 20 related 1 (Drosophila)	149					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			endometrium(1)|kidney(4)|liver(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(2)	13				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCCTACTCCCTGTCTCCCG	0.642000													29	30					0	0	1	0	0
PRKAA2	5563	broad.mit.edu	37	1	57169798	57169798	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:57169798G>A	ENST00000371244.4	+	7	1009	c.943G>A	c.(943-945)Gac>Aac	p.D315N		NM_006252.3	NP_006243.2	P54646	AAPK2_HUMAN	protein kinase, AMP-activated, alpha 2 catalytic subunit	315					carnitine shuttle|cell cycle arrest|cholesterol biosynthetic process|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm	ATP binding|metal ion binding			breast(6)|endometrium(1)|large_intestine(6)|lung(7)|ovary(1)|prostate(1)|stomach(1)	23						ATATAGTGGTGACCCTCAAGA	0.408000													36	39					0	0	1	0	0
FAM19A4	151647	broad.mit.edu	37	3	68802051	68802051	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:68802051C>T	ENST00000295569.7	-	4	741	c.249G>A	c.(247-249)gtG>gtA	p.V83V		NM_001005527.2|NM_182522.4	NP_001005527.1|NP_872328.1	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine (C-C motif)-like), member A4	83						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(5)|skin(2)	10		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		TTGTGCCCGCCACCTGTCCCG	0.537000													17	31					0	0	1	0	0
ABCA13	154664	broad.mit.edu	37	7	48316016	48316016	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:48316016G>A	ENST00000435803.1	+	17	6777	c.6753G>A	c.(6751-6753)agG>agA	p.R2251R		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2251					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						AAACTAGTAGGAAAACAGTTC	0.338000													4	3					0	0	1	0	0
DFNA5	1687	broad.mit.edu	37	7	24756935	24756935	+	Missense_Mutation	SNP	G	G	A	rs145754170		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:24756935G>A	ENST00000545231.1	-	7	1293	c.143C>T	c.(142-144)cCa>cTa	p.P48L	DFNA5_ENST00000559637.1_5'UTR|DFNA5_ENST00000419307.1_Missense_Mutation_p.P48L|DFNA5_ENST00000409970.1_Missense_Mutation_p.P48L|DFNA5_ENST00000409775.3_Missense_Mutation_p.P212L|DFNA5_ENST00000342947.3_Missense_Mutation_p.P212L			O60443	DFNA5_HUMAN	deafness, autosomal dominant 5	212					sensory perception of sound					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(3)|stomach(1)	19						GGTGGCAGCTGGGATCTCCAG	0.592000													17	27					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55782888	55782888	+	Missense_Mutation	SNP	G	G	A	rs34553661		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:55782888G>A	ENST00000373965.2	-	20	2705	c.2311C>T	c.(2311-2313)Cgt>Tgt	p.R771C	PCDH15_ENST00000395432.2_Missense_Mutation_p.R727C|PCDH15_ENST00000395433.1_Missense_Mutation_p.R742C|PCDH15_ENST00000373955.1_Missense_Mutation_p.R764C|PCDH15_ENST00000361849.3_Missense_Mutation_p.R764C|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000414778.1_Missense_Mutation_p.R769C|PCDH15_ENST00000409834.1_Missense_Mutation_p.R375C|PCDH15_ENST00000320301.6_Missense_Mutation_p.R764C|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395438.1_Missense_Mutation_p.R764C|PCDH15_ENST00000395430.1_Missense_Mutation_p.R764C|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000395445.1_Missense_Mutation_p.R771C|PCDH15_ENST00000437009.1_Missense_Mutation_p.R693C|PCDH15_ENST00000395446.1_Intron	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	764	Cadherin 7.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GATGTGATACGAAAAAGATTA	0.368000										HNSCC(58;0.16)			17	9					0	0	1	0	0
COL26A1	136227	broad.mit.edu	37	7	101200855	101200855	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:101200855C>T	ENST00000313669.7	+	0	1560				COL26A1_ENST00000528707.1_RNA|COL26A1_ENST00000397927.3_RNA	NM_133457.2	NP_597714.2			collagen, type XXVI, alpha 1																		GAGACCCAGCCCCAGAGGCCT	0.627000													4	14					0	0	1	0	0
ZNF595	152687	broad.mit.edu	37	4	59341	59341	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:59341G>A	ENST00000509152.2	+	2	207	c.22G>A	c.(22-24)Gat>Aat	p.D8N	ZNF595_ENST00000339368.6_3'UTR|ZNF595_ENST00000526473.2_Missense_Mutation_p.D8N					zinc finger protein 595											endometrium(5)|kidney(1)|large_intestine(1)|lung(11)|prostate(2)	20		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0654)|Epithelial(2;0.0921)|all cancers(2;0.146)|LUSC - Lung squamous cell carcinoma(95;0.173)		AACATTCAGGGATGTGGCCAT	0.418000													25	218					0	0	1	0	0
IL5RA	3568	broad.mit.edu	37	3	3111974	3111974	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:3111974C>T	ENST00000446632.2	-	12	1772	c.1198G>A	c.(1198-1200)Gaa>Aaa	p.E400K	IL5RA_ENST00000438560.1_Silent_p.R371R|IL5RA_ENST00000445864.2_Missense_Mutation_p.E191K|IL5RA_ENST00000418488.2_Missense_Mutation_p.E305K|IL5RA_ENST00000256452.3_Missense_Mutation_p.E400K	NM_175726.3	NP_783853.1	Q01344	IL5RA_HUMAN	interleukin 5 receptor, alpha	400					cell proliferation	extracellular space|integral to membrane|plasma membrane	interleukin-5 receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(9)|ovary(1)|prostate(2)|skin(2)	24				Epithelial(13;0.00278)|all cancers(10;0.00809)|OV - Ovarian serous cystadenocarcinoma(96;0.00944)		ACTTCAATTTCCGTCTCACTG	0.398000													45	58					0	0	1	0	0
ATAD3C	219293	broad.mit.edu	37	1	1389811	1389811	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:1389811G>A	ENST00000378785.2	+	4	1304	c.309G>A	c.(307-309)ctG>ctA	p.L103L		NM_001039211.2	NP_001034300.2	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	103							ATP binding|nucleoside-triphosphatase activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|lung(4)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		AGGCTCGGCTGGGGAAGCCGT	0.672000													6	4					0	0	1	0	0
ATG14	22863	broad.mit.edu	37	14	55836455	55836455	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:55836455G>A	ENST00000247178.5	-	10	1396	c.1361C>T	c.(1360-1362)tCc>tTc	p.S454F		NM_014924.4	NP_055739.2	Q6ZNE5	BAKOR_HUMAN	autophagy related 14	454					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(2)	13						CTGACTCTGGGAGACTTCCAC	0.587000													18	15					0	0	1	0	0
SLC26A4	5172	broad.mit.edu	37	7	107315415	107315415	+	Missense_Mutation	SNP	G	G	A	rs111033303	byFrequency	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:107315415G>A	ENST00000265715.3	+	6	850	c.626G>A	c.(625-627)gGa>gAa	p.G209E		NM_000441.1	NP_000432.1	O43511	S26A4_HUMAN	solute carrier family 26 (anion exchanger), member 4	209			G -> V (in DFNB4 and PDS; severely reduces iodide transport without affecting protein localization to cell membrane).		regulation of pH|regulation of protein localization|sensory perception of sound	apical plasma membrane|integral to membrane	chloride transmembrane transporter activity|inorganic anion exchanger activity|iodide transmembrane transporter activity|secondary active sulfate transmembrane transporter activity			central_nervous_system(2)|endometrium(1)|kidney(5)|large_intestine(8)|lung(16)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	46						TTGCAGATTGGATTCATAGTG	0.408000									Pendred syndrome				35	70					0	0	1	0	0
MEPCE	56257	broad.mit.edu	37	7	100029116	100029116	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:100029116C>T	ENST00000310512.2	+	1	1863	c.1475C>T	c.(1474-1476)tCc>tTc	p.S492F	MEPCE_ENST00000414441.1_Missense_Mutation_p.S23F	NM_019606.5	NP_062552.2	Q7L2J0	MEPCE_HUMAN	methylphosphate capping enzyme	492	Bin3-type SAM.						methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(2)|lung(9)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CACTACCTTTCCGAGGAGCTG	0.627000													17	22					0	0	1	0	0
EFCAB6	64800	broad.mit.edu	37	22	43996027	43996027	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:43996027C>T	ENST00000262726.7	-	23	3051	c.2798G>A	c.(2797-2799)gGt>gAt	p.G933D	EFCAB6_ENST00000396231.2_Missense_Mutation_p.G781D	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	933					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				TGTAAAATGACCCATGAAGTT	0.483000													40	235					0	0	1	0	0
USHBP1	83878	broad.mit.edu	37	19	17370177	17370177	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:17370177C>T	ENST00000252597.3	-	7	1140	c.967G>A	c.(967-969)Ggc>Agc	p.G323S	USHBP1_ENST00000431146.2_Missense_Mutation_p.G259S	NM_031941.3	NP_114147.2	Q8N6Y0	USBP1_HUMAN	Usher syndrome 1C binding protein 1	323							PDZ domain binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(10)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44						TCACAGCGGCCCTTGTATCCC	0.567000													14	20					0	0	1	0	0
OR2T12	127064	broad.mit.edu	37	1	248458105	248458105	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:248458105C>T	ENST00000317996.1	-	1	775	c.776G>A	c.(775-777)aGa>aAa	p.R259K		NM_001004692.1	NP_001004692.1	Q8NG77	O2T12_HUMAN	olfactory receptor, family 2, subfamily T, member 12	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(3)|large_intestine(3)|lung(25)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0201)			GGATTTGGGTCTCATATAGGT	0.483000													24	53					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57642220	57642220	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:57642220G>A	ENST00000254181.4	+	4	2631	c.2177G>A	c.(2176-2178)gGa>gAa	p.G726E	USP29_ENST00000598197.1_Missense_Mutation_p.G726E	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	726					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATTCCAGAAGGATCTCAAGGA	0.428000													13	21					0	0	1	0	0
DNM3	26052	broad.mit.edu	37	1	172100375	172100375	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:172100375G>A	ENST00000358155.4	+	14	1782	c.1606G>A	c.(1606-1608)Gga>Aga	p.G536R	DNM3_ENST00000367733.2_Missense_Mutation_p.G536R|DNM3_ENST00000355305.5_Missense_Mutation_p.G546R|DNM3_ENST00000520906.1_Missense_Mutation_p.G536R|DNM3_ENST00000367731.1_Missense_Mutation_p.G536R	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	546	PH.				endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						CGGCTCGAAGGGATACTGGTT	0.433000													5	9					0	0	1	0	0
NAALADL1	10004	broad.mit.edu	37	11	64825960	64825960	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:64825960C>T	ENST00000358658.3	-	1	61	c.34G>A	c.(34-36)Ggg>Agg	p.G12R	NAALADL1_ENST00000356632.3_Missense_Mutation_p.G12R|NAALADL1_ENST00000355369.2_Missense_Mutation_p.G12R|NAALADL1_ENST00000340252.4_Missense_Mutation_p.G12R|NAALADL1_ENST00000355721.3_Missense_Mutation_p.G12R|NAALADL1_ENST00000339885.2_Missense_Mutation_p.G12R	NM_005468.2	NP_005459.2	Q9UQQ1	NALDL_HUMAN	N-acetylated alpha-linked acidic dipeptidase-like 1	12					proteolysis	apical plasma membrane|integral to membrane	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	29						GCAGCAGCCCCCAGCCCCAGC	0.607000													12	16					0	0	1	0	0
PLEKHG3	26030	broad.mit.edu	37	14	65209862	65209862	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:65209862C>T	ENST00000247226.7	+	15	3241	c.2933C>T	c.(2932-2934)tCc>tTc	p.S978F	PLEKHG3_ENST00000492928.1_Intron|PLEKHG3_ENST00000394691.1_Missense_Mutation_p.S1034F|PLEKHG3_ENST00000484731.2_Missense_Mutation_p.S539F|PLEKHG3_ENST00000471182.2_Missense_Mutation_p.S567F	NM_015549.1	NP_056364.1	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 3	1034					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(5)|kidney(2)|large_intestine(1)|lung(14)|prostate(2)|skin(3)|urinary_tract(2)	29				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		GGCCGGCCCTCCGCCCGGAGC	0.682000													59	77					0	0	1	0	0
KRT23	25984	broad.mit.edu	37	17	39084593	39084593	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:39084593T>A	ENST00000209718.3	-	6	1242	c.818A>T	c.(817-819)gAg>gTg	p.E273V	AC004231.2_ENST00000418393.1_RNA|KRT23_ENST00000436344.3_Missense_Mutation_p.E136V	NM_015515.3	NP_056330.3	Q9C075	K1C23_HUMAN	keratin 23 (histone deacetylase inducible)	273	Coil 2.|Rod.					intermediate filament	structural molecule activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21		Breast(137;0.000301)|Ovarian(249;0.15)				ACTGGCTGCCTCCTGGGACAT	0.547000													30	81					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85459152	85459152	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:85459152G>A	ENST00000393217.2	+	9	2565	c.2504G>A	c.(2503-2505)aGc>aAc	p.S835N		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	835										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		TCTTTGCACAGCCTGAGTAAT	0.358000													16	43					0	0	1	0	0
GPC5	2262	broad.mit.edu	37	13	92101015	92101015	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:92101015G>A	ENST00000377067.3	+	2	536	c.163_splice	c.e2-1	p.G55_splice		NM_004466.4	NP_004457.1	P78333	GPC5_HUMAN	glypican 5	55						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(4)|endometrium(6)|kidney(4)|large_intestine(7)|lung(34)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				TGTGTTCCAGGACCTGATCTT	0.413000													53	27					0	0	1	0	0
RPGRIP1	57096	broad.mit.edu	37	14	21796596	21796596	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:21796596C>T	ENST00000206660.6	+	18	2909	c.2909C>T	c.(2908-2910)tCt>tTt	p.S970F	RPGRIP1_ENST00000400017.2_Missense_Mutation_p.S970F|RPGRIP1_ENST00000557771.1_Missense_Mutation_p.S932F|RPGRIP1_ENST00000556336.1_Missense_Mutation_p.S627F|RPGRIP1_ENST00000382933.4_Missense_Mutation_p.S296F|RPGRIP1_ENST00000307974.4_Missense_Mutation_p.S329F			Q96KN7	RPGR1_HUMAN	retinitis pigmentosa GTPase regulator interacting protein 1	970	Interaction with RPGR.				response to stimulus|visual perception	cilium				breast(3)|endometrium(2)|kidney(4)|large_intestine(11)|lung(10)|ovary(4)|pancreas(1)|prostate(3)|stomach(1)	39	all_cancers(95;0.0017)	all_cancers(140;0.0973)	Epithelial(56;6.24e-07)|all cancers(55;6.56e-06)	GBM - Glioblastoma multiforme(265;0.00888)		CAGATGGCATCTCCTGAGGTT	0.443000													11	32					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10081489	10081489	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:10081489C>T	ENST00000287647.3	+	9	748	c.655C>T	c.(655-657)Cta>Tta	p.L219L	FANCD2_ENST00000431693.1_Silent_p.L219L|FANCD2_ENST00000383806.1_Silent_p.L219L|FANCD2_ENST00000438741.1_3'UTR|FANCD2_ENST00000383807.1_Silent_p.L219L|FANCD2_ENST00000419585.1_Silent_p.L219L	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	219	Interaction with FANCE.				DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		ACCTGAGATCCTAGGGGATTC	0.512000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				18	37					0	0	1	0	0
RP11-909M7.3	0	broad.mit.edu	37	14	101439060	101439060	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:101439060C>T	ENST00000554693.2	+	0	384				SNORD114-15_ENST00000364687.1_RNA																							GAATATGTGTCTGGAACTCTG	0.368000													23	39					0	0	1	0	0
ATP2B3	492	broad.mit.edu	37	X	152801762	152801762	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:152801762G>A	ENST00000370186.1	+	2	383	c.57G>A	c.(55-57)cgG>cgA	p.R19R	ATP2B3_ENST00000263519.4_Silent_p.R19R|ATP2B3_ENST00000349466.2_Silent_p.R19R|ATP2B3_ENST00000393842.1_Silent_p.R19R|ATP2B3_ENST00000370181.2_Silent_p.R19R|ATP2B3_ENST00000359149.3_Silent_p.R19R			Q16720	AT2B3_HUMAN	ATPase, Ca++ transporting, plasma membrane 3	19					ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			NS(2)|breast(5)|endometrium(7)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(3)	50	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					AGCAGCAGCGGGATGTCCCCC	0.642000													4	3					0	0	1	0	0
SYT10	341359	broad.mit.edu	37	12	33560108	33560108	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:33560108G>A	ENST00000228567.3	-	3	989	c.693C>T	c.(691-693)atC>atT	p.I231I	SYT10_ENST00000535526.1_Silent_p.I50I	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	231						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					GTTTCCCACAGATTTTGACAT	0.383000													10	20					0	0	1	0	0
TECTB	6975	broad.mit.edu	37	10	114043548	114043548	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:114043548C>T	ENST00000369422.3	+	1	56	c.56C>T	c.(55-57)tCg>tTg	p.S19L		NM_058222.1	NP_478129.1	Q96PL2	TECTB_HUMAN	tectorin beta	19	ZP.					anchored to membrane|plasma membrane|proteinaceous extracellular matrix				kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	19		Colorectal(252;0.198)		Epithelial(162;0.0143)|all cancers(201;0.0242)		TCTGCAAAATCGTGTGCTCCA	0.478000													9	2					0	0	1	0	0
SMEK1	55671	broad.mit.edu	37	14	91927910	91927910	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:91927910G>A	ENST00000554684.1	-	14	2663	c.2167C>T	c.(2167-2169)Ctt>Ttt	p.L723F	SMEK1_ENST00000555718.1_5'UTR|SMEK1_ENST00000555462.1_Missense_Mutation_p.L497F|SMEK1_ENST00000428424.2_Missense_Mutation_p.L497F|SMEK1_ENST00000337238.4_Missense_Mutation_p.L723F|SMEK1_ENST00000554943.1_Missense_Mutation_p.L736F			Q6IN85	P4R3A_HUMAN	SMEK homolog 1, suppressor of mek1 (Dictyostelium)	736						microtubule organizing center|nucleus	protein binding			NS(1)|endometrium(1)|kidney(1)|liver(1)|lung(1)|stomach(1)	6		all_cancers(154;0.0691)|all_epithelial(191;0.219)		COAD - Colon adenocarcinoma(157;0.221)		CGTCCAGAAAGGTTTGTTTTC	0.428000													41	68					0	0	1	0	0
MOV10	4343	broad.mit.edu	37	1	113232122	113232122	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:113232122C>T	ENST00000369644.1	+	5	1288	c.259C>T	c.(259-261)Ctg>Ttg	p.L87L	MOV10_ENST00000413052.2_Silent_p.L143L|MOV10_ENST00000468624.1_3'UTR|MOV10_ENST00000369645.1_Silent_p.L143L|MOV10_ENST00000357443.2_Silent_p.L143L			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	143					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		CCTTATCCGCCTGGATTTGAA	0.587000													25	37					0	0	1	0	0
FAM49A	81553	broad.mit.edu	37	2	16734245	16734245	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:16734245C>T	ENST00000381323.3	-	12	1151	c.931G>A	c.(931-933)Gat>Aat	p.D311N	FAM49A_ENST00000406434.1_Missense_Mutation_p.D311N|FAM49A_ENST00000355549.2_Missense_Mutation_p.D311N	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	311						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			GTTGATTCATCGTTCAAGTGC	0.433000													19	5					0	0	1	0	0
STX16	8675	broad.mit.edu	37	20	57244505	57244505	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:57244505C>T	ENST00000371141.4	+	5	1276	c.552C>T	c.(550-552)ctC>ctT	p.L184L	STX16_ENST00000359617.4_Silent_p.L131L|STX16_ENST00000496003.1_Intron|STX16_ENST00000361770.5_Silent_p.L167L|STX16-NPEPL1_ENST00000530122.1_Silent_p.L184L|STX16_ENST00000371132.4_Silent_p.L163L|STX16_ENST00000355957.5_Silent_p.L167L|STX16_ENST00000361830.3_Silent_p.L184L|STX16_ENST00000358029.4_Silent_p.L180L	NM_001001433.2	NP_001001433.1	O14662	STX16_HUMAN	syntaxin 16	184					intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane|microsome|SNARE complex	SNAP receptor activity			breast(1)|cervix(1)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(1)	17	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;3.73e-09)|Epithelial(14;8.54e-06)|all cancers(14;6.89e-05)			CAGGCTACCTCAAACGTGAGT	0.542000													4	10					0	0	1	0	0
HR	55806	broad.mit.edu	37	8	21973258	21973258	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:21973258G>A	ENST00000381418.4	-	19	5005	c.3525C>T	c.(3523-3525)ttC>ttT	p.F1175F	HR_ENST00000312841.8_Silent_p.F1120F	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	1175							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		TCACTGCTTGGAACACAGCCC	0.547000													10	16					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32634774	32634774	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:32634774C>T	ENST00000242310.4	-	1	893	c.804G>A	c.(802-804)ggG>ggA	p.G268G	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	268					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GGACATTCTTCCCTGGTCCAA	0.493000													18	47					0	0	1	0	0
MED12L	116931	broad.mit.edu	37	3	151112519	151112519	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:151112519G>C	ENST00000474524.1	+	37	5617	c.5579G>C	c.(5578-5580)cGg>cCg	p.R1860P	MED12L_ENST00000273432.4_Missense_Mutation_p.R1720P	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	1860					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			ATGCTACAGCGGCGCTCAGGC	0.527000													31	58					0	0	1	0	0
GRN	2896	broad.mit.edu	37	17	42426862	42426862	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:42426862C>T	ENST00000053867.3	+	3	269	c.207C>T	c.(205-207)gcC>gcT	p.A69A	GRN_ENST00000589265.1_Silent_p.A69A	NM_002087.2	NP_002078.1	P28799	GRN_HUMAN	granulin	69			A -> T.		signal transduction	extracellular space	cytokine activity|growth factor activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		ACTGCTCTGCCGGCCACTCCT	0.572000													41	42					0	0	1	0	0
RASSF6	166824	broad.mit.edu	37	4	74453571	74453571	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:74453571C>T	ENST00000307439.5	-	5	662	c.368G>A	c.(367-369)aGg>aAg	p.R123K	RASSF6_ENST00000335049.5_Missense_Mutation_p.R111K|RASSF6_ENST00000342081.3_Missense_Mutation_p.R155K|RASSF6_ENST00000395777.2_Missense_Mutation_p.R123K	NM_001270391.1|NM_177532.4	NP_001257320.1|NP_803876.1	Q6ZTQ3	RASF6_HUMAN	Ras association (RalGDS/AF-6) domain family member 6	155					apoptosis|signal transduction		protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|pancreas(2)|skin(2)	17	Breast(15;0.00102)		all cancers(17;0.00104)|Lung(101;0.128)|LUSC - Lung squamous cell carcinoma(112;0.187)			CTGGGAATTCCTTTTTTCAGA	0.373000													21	37					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136597363	136597363	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:136597363C>T	ENST00000531224.1	-	5	1552	c.1300G>A	c.(1300-1302)Gaa>Aaa	p.E434K	BCLAF1_ENST00000527759.1_Missense_Mutation_p.E432K|BCLAF1_ENST00000527536.1_Missense_Mutation_p.E434K|BCLAF1_ENST00000392348.2_Missense_Mutation_p.E432K|BCLAF1_ENST00000530767.1_Intron|BCLAF1_ENST00000353331.4_Missense_Mutation_p.E432K	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	434					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		TTGAGTCCTTCCTCCTCAGTA	0.398000													34	78					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50248559	50248559	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:50248559C>T	ENST00000246801.3	-	7	1169	c.1087G>A	c.(1087-1089)Gac>Aac	p.D363N	TSKS_ENST00000358830.3_Missense_Mutation_p.D163N	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	363							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		AGGAAGCCGTCGACCCTGCCG	0.706000													6	21					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55540720	55540720	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:55540720G>A	ENST00000220676.1	+	4	4426	c.4278G>A	c.(4276-4278)agG>agA	p.R1426R		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1426					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GTTCACTAAGGAAGTTTCAGG	0.368000													11	19					0	0	1	0	0
C1orf95	375057	broad.mit.edu	37	1	226784624	226784624	+	Silent	SNP	C	C	T	rs148475965		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:226784624C>T	ENST00000366788.3	+	2	429	c.324C>T	c.(322-324)atC>atT	p.I108I	C1orf95_ENST00000366789.4_Silent_p.I108I	NM_001003665.3	NP_001003665.1	Q69YW2	CA095_HUMAN	chromosome 1 open reading frame 95	108						integral to membrane				large_intestine(1)|lung(4)|ovary(3)	8	Breast(184;0.133)	Prostate(94;0.0885)		GBM - Glioblastoma multiforme(131;0.113)		TCACTGCCATCGTCATGGTGG	0.612000													43	66					0	0	1	0	0
NRD1	4898	broad.mit.edu	37	1	52277704	52277704	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:52277704G>A	ENST00000354831.7	-	17	2134	c.1945C>T	c.(1945-1947)Ctc>Ttc	p.L649F	NRD1_ENST00000544028.1_Missense_Mutation_p.L449F|NRD1_ENST00000352171.7_Missense_Mutation_p.L581F|NRD1_ENST00000539524.1_Missense_Mutation_p.L517F|NRD1_ENST00000485608.1_5'UTR	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)	580					cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						TCTCCAGTGAGAATGTCCTGC	0.403000													15	28					0	0	1	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887472	9887472	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:9887472C>T	ENST00000306084.6	+	2	1195	c.996C>T	c.(994-996)tcC>tcT	p.S332S	TXNDC2_ENST00000357775.4_Silent_p.S265S|TXNDC2_ENST00000536353.2_3'UTR	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	332	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						TCCCCAAGTCCCTAGAGGAAG	0.582000													33	62					0	0	1	0	0
SPRED2	200734	broad.mit.edu	37	2	65543951	65543951	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:65543951G>A	ENST00000356388.4	-	5	694	c.505C>T	c.(505-507)Ccc>Tcc	p.P169S	SPRED2_ENST00000443619.2_Missense_Mutation_p.P166S|SPRED2_ENST00000474228.1_5'UTR	NM_181784.2	NP_861449.2	Q7Z698	SPRE2_HUMAN	sprouty-related, EVH1 domain containing 2	169					inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(7)|ovary(2)|upper_aerodigestive_tract(3)	34						CAGGATGTGGGAGAGGAGATT	0.512000													7	2					0	0	1	0	0
GPC6	10082	broad.mit.edu	37	13	94482562	94482562	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:94482562G>A	ENST00000377047.4	+	3	1090	c.475G>A	c.(475-477)Gaa>Aaa	p.E159K	GPC6-AS2_ENST00000445540.1_RNA	NM_005708.3	NP_005699.1	Q9Y625	GPC6_HUMAN	glypican 6	159						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	38	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				GAATCTGGAGGAAATGCTCAA	0.473000													8	40					0	0	1	0	0
ZNF343	79175	broad.mit.edu	37	20	2465038	2465038	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:2465038G>A	ENST00000278772.4	-	6	1056	c.569C>T	c.(568-570)tCa>tTa	p.S190L	RP4-734P14.4_ENST00000461548.1_Intron	NM_024325.4	NP_077301.4	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|skin(4)|upper_aerodigestive_tract(1)	25						GAATGCCCTTGAGGTTTCTCT	0.517000													18	22					0	0	1	0	0
OR2G6	391211	broad.mit.edu	37	1	248685814	248685814	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:248685814C>T	ENST00000343414.4	+	1	899	c.867C>T	c.(865-867)atC>atT	p.I289I		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	289					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACCCCATTATCTACACTCTGA	0.443000													19	20					0	0	1	0	0
GLDN	342035	broad.mit.edu	37	15	51692428	51692428	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:51692428G>A	ENST00000335449.6	+	7	913	c.857G>A	c.(856-858)gGa>gAa	p.G286E	GLDN_ENST00000396399.2_Missense_Mutation_p.G162E	NM_181789.2	NP_861454.2	Q6ZMI3	GLDN_HUMAN	gliomedin	286					cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	19				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		ACCTTGGTTGGAAAAGCTGAT	0.413000													18	22					0	0	1	0	0
NMT1	4836	broad.mit.edu	37	17	43176825	43176825	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:43176825C>T	ENST00000592782.1	+	9	1068	c.937C>T	c.(937-939)Cac>Tac	p.H313Y	NMT1_ENST00000258960.2_Missense_Mutation_p.H313Y			P30419	NMT1_HUMAN	N-myristoyltransferase 1	313					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)	8		Prostate(33;0.155)				GAAGTTCTCCCACCTGAGCAG	0.577000											OREG0024470	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	63					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23521231	23521231	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:23521231C>T	ENST00000296682.3	+	6	633	c.451C>T	c.(451-453)Cca>Tca	p.P151S		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	151					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						GGCTCAGAAACCAGTGTCCCC	0.443000										HNSCC(3;0.000094)			13	12					0	0	1	0	0
RP11-337C18.8	0	broad.mit.edu	37	1	146650404	146650404	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:146650404G>A	ENST00000607149.1	+	0	350																											GTTTATCCAGGAAAACATTTT	0.368000													14	23					0	0	1	0	0
ZSWIM2	151112	broad.mit.edu	37	2	187702271	187702271	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:187702271C>T	ENST00000295131.2	-	5	544	c.505G>A	c.(505-507)Ggc>Agc	p.G169S		NM_182521.2	NP_872327.2	Q8NEG5	ZSWM2_HUMAN	zinc finger, SWIM-type containing 2	169					apoptosis		zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(28)|ovary(2)|prostate(4)|skin(6)|urinary_tract(1)	52			OV - Ovarian serous cystadenocarcinoma(117;0.0274)|Epithelial(96;0.164)			ATACTATTGCCACAGCCAAAC	0.289000													11	4					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42185570	42185570	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:42185570C>T	ENST00000320955.6	-	2	353	c.126G>A	c.(124-126)acG>acA	p.T42T	RP11-23P13.6_ENST00000309874.2_RNA|RP11-23P13.6_ENST00000564432.2_RNA	NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	42	Actin-binding.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		GAATGTGGCCCGTCTCGTACT	0.607000													20	17					0	0	1	0	0
NPSR1	387129	broad.mit.edu	37	7	34698086	34698086	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:34698086C>T	ENST00000360581.1	+	1	190	c.62C>T	c.(61-63)tCt>tTt	p.S21F	AC005493.1_ENST00000399077.1_Intron|NPSR1_ENST00000381553.3_Missense_Mutation_p.S21F|NPSR1_ENST00000465305.1_Missense_Mutation_p.S21F|NPSR1_ENST00000531252.1_Missense_Mutation_p.S21F|NPSR1-AS1_ENST00000419766.1_RNA|NPSR1_ENST00000381542.1_Missense_Mutation_p.S21F|NPSR1_ENST00000359791.1_Missense_Mutation_p.S21F|NPSR1_ENST00000381539.3_Missense_Mutation_p.S21F	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	21						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	ACGCTGGATTCTTCCCCAGTG	0.537000													18	31					0	0	1	0	0
OR6S1	341799	broad.mit.edu	37	14	21108902	21108902	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:21108902C>T	ENST00000320704.3	-	1	948	c.949G>A	c.(949-951)Ggg>Agg	p.G317R		NM_001001968.1	NP_001001968.1	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S, member 1	317					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		AAAAGATTCCCTAAAACGCCT	0.343000													38	61					0	0	1	0	0
KIAA1199	57214	broad.mit.edu	37	15	81212479	81212479	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:81212479C>T	ENST00000394685.3	+	15	2261	c.1842C>T	c.(1840-1842)ttC>ttT	p.F614F	KIAA1199_ENST00000220244.3_Silent_p.F614F|KIAA1199_ENST00000356249.5_Silent_p.F614F|RP11-351M8.2_ENST00000560873.1_RNA			Q8WUJ3	K1199_HUMAN	KIAA1199	614										breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49						ACTGCTTCTTCACGGAAGATG	0.532000													12	24					0	0	1	0	0
CFHR2	3080	broad.mit.edu	37	1	196927045	196927045	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:196927045C>T	ENST00000367415.4	+	4	569	c.455C>T	c.(454-456)cCt>cTt	p.P152L	CFHR2_ENST00000367421.3_Missense_Mutation_p.P152L|CFHR2_ENST00000476712.1_3'UTR	NM_005666.2	NP_005657.1	P36980	FHR2_HUMAN	complement factor H-related 2	152	Sushi 3.					extracellular region				large_intestine(2)|ovary(1)|skin(3)	6						TGTGGGCCCCCTCCACCTATT	0.383000													16	37					0	0	1	0	0
CXorf22	170063	broad.mit.edu	37	X	35993912	35993912	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:35993912G>A	ENST00000297866.5	+	15	2661	c.2595G>A	c.(2593-2595)atG>atA	p.M865I		NM_152632.3	NP_689845.2	Q6ZTR5	CX022_HUMAN	chromosome X open reading frame 22	865										breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(3)	44						GCTTCTTCATGAAAACATGTT	0.438000													40	65					0	0	1	0	0
CCR3	1232	broad.mit.edu	37	3	46307396	46307396	+	Silent	SNP	C	C	T	rs76939117		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:46307396C>T	ENST00000357422.2	+	4	1290	c.747C>T	c.(745-747)ttC>ttT	p.F249F	CCR3_ENST00000545097.1_Silent_p.F270F|CCR3_ENST00000541018.1_Silent_p.F249F|CCR3_ENST00000395942.2_Silent_p.F249F|CCR3_ENST00000395940.2_Silent_p.F249F			P51677	CCR3_HUMAN	chemokine (C-C motif) receptor 3	249					cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(3)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CGGTGTTTTTCATTTTCTGGA	0.458000													13	13					0	0	1	0	0
IRX1	79192	broad.mit.edu	37	5	3600290	3600290	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:3600290C>T	ENST00000302006.3	+	2	1280	c.1228C>T	c.(1228-1230)Cca>Tca	p.P410S	CTD-2012M11.3_ENST00000559410.1_RNA	NM_024337.3	NP_077313.3	P78414	IRX1_HUMAN	iroquois homeobox 1	410	Poly-Pro.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|endometrium(5)|kidney(2)|large_intestine(5)|lung(18)|ovary(2)|pancreas(1)|prostate(5)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						TCCTGCACCTCCACCACCGCA	0.701000													16	29					0	0	1	0	0
BEND4	389206	broad.mit.edu	37	4	42145871	42145871	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:42145871C>T	ENST00000502486.1	-	3	1207	c.628G>A	c.(628-630)Gaa>Aaa	p.E210K	BEND4_ENST00000504360.1_Missense_Mutation_p.E206K	NM_207406.3	NP_997289.2	Q6ZU67	BEND4_HUMAN	BEN domain containing 4	210								p.E206K(1)		NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						TCCTGTCTTTCGTTGTAACTT	0.443000													6	10					0	0	1	0	0
OR52B6	340980	broad.mit.edu	37	11	5602505	5602505	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:5602505C>T	ENST00000345043.2	+	1	399	c.399C>T	c.(397-399)gtC>gtT	p.V133V	AC015691.13_ENST00000394793.2_RNA|HBG2_ENST00000380259.2_Intron	NM_001005162.2	NP_001005162.2	Q8NGF0	O52B6_HUMAN	olfactory receptor, family 52, subfamily B, member 6	133					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|lung(7)|ovary(1)|prostate(1)	12		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;3.56e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTCTGCTGTCCTGCTGGCCA	0.522000													20	40					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175898159	175898159	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:175898159G>A	ENST00000359240.3	+	5	2153	c.1483G>A	c.(1483-1485)Gaa>Aaa	p.E495K	ADAM29_ENST00000445694.1_Missense_Mutation_p.E495K|ADAM29_ENST00000514159.1_Missense_Mutation_p.E495K|ADAM29_ENST00000404450.4_Missense_Mutation_p.E495K	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	495	Cys-rich.				proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		CTACTGCTATGAAAAGAGCTG	0.453000													20	33					0	0	1	0	0
OR6C65	403282	broad.mit.edu	37	12	55795201	55795201	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:55795201C>T	ENST00000379665.2	+	1	988	c.889C>T	c.(889-891)Cag>Tag	p.Q297*		NM_001005518.1	NP_001005518.1	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C, member 65	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(3)|lung(9)	15						GCAGGTGAAACAGGCCCTTAG	0.358000													7	18					0	0	1	0	0
KCTD16	57528	broad.mit.edu	37	5	143586424	143586424	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:143586424C>T	ENST00000507359.2	+	2	1238	c.147C>T	c.(145-147)tcC>tcT	p.S49S	KCTD16_ENST00000512467.1_Silent_p.S49S	NM_020768.3	NP_065819.1	Q68DU8	KCD16_HUMAN	potassium channel tetramerization domain containing 16	49	BTB.					cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(5)|lung(9)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	21		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			TCCCTCATTCCCTCCTGTGGA	0.478000													12	19					0	0	1	0	0
PCCB	5096	broad.mit.edu	37	3	136046515	136046515	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:136046515C>T	ENST00000471595.1	+	13	1357	c.1339C>T	c.(1339-1341)Ctt>Ttt	p.L447F	PCCB_ENST00000474833.1_3'UTR|PCCB_ENST00000482086.1_Missense_Mutation_p.L331F|PCCB_ENST00000251654.4_Missense_Mutation_p.L447F|PCCB_ENST00000462637.1_Missense_Mutation_p.L424F|PCCB_ENST00000469217.1_Missense_Mutation_p.L467F|PCCB_ENST00000483687.1_Missense_Mutation_p.L428F|PCCB_ENST00000466072.1_Missense_Mutation_p.L467F|PCCB_ENST00000478469.1_Intron|PCCB_ENST00000490504.1_Missense_Mutation_p.L390F|PCCB_ENST00000468777.1_Missense_Mutation_p.L478F			P05166	PCCB_HUMAN	propionyl CoA carboxylase, beta polypeptide	447	Carboxyltransferase.				fatty acid beta-oxidation	mitochondrial matrix	ATP binding|propionyl-CoA carboxylase activity			breast(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|urinary_tract(1)	25					Biotin(DB00121)|L-Valine(DB00161)	CTCTAAGCACCTTTGTGGTGA	0.512000													18	16					0	0	1	0	0
CNOT10	25904	broad.mit.edu	37	3	32800955	32800955	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:32800955C>T	ENST00000328834.5	+	14	1917	c.1601C>T	c.(1600-1602)tCc>tTc	p.S534F	CNOT10_ENST00000538368.1_Missense_Mutation_p.S306F|CNOT10_ENST00000454516.2_Missense_Mutation_p.S594F|CNOT10_ENST00000331889.6_Missense_Mutation_p.S507F	NM_015442.2	NP_056257.1	Q9H9A5	CNOTA_HUMAN	CCR4-NOT transcription complex, subunit 10	534					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|prostate(1)|skin(3)	23						TATAGGTGCTCCATACTTGCT	0.428000													143	236					0	0	1	0	0
BCL6	604	broad.mit.edu	37	3	187444562	187444562	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:187444562G>A	ENST00000406870.2	-	7	2031	c.1665C>T	c.(1663-1665)ttC>ttT	p.F555F	RP11-211G3.3_ENST00000437407.1_Intron|BCL6_ENST00000450123.2_Intron|RP11-211G3.3_ENST00000449623.1_Intron|BCL6_ENST00000232014.4_Silent_p.F555F	NM_001706.4	NP_001697.2	P41182	BCL6_HUMAN	B-cell CLL/lymphoma 6	555					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(9)|lung(10)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	40	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		CCTTGTAGCGGAAGGAGGCCT	0.602000			"""T, Mis"""	"""IG loci, ZNFN1A1, LCP1, PIM1, TFRC, CIITA, NACA, HSPCB, HSPCA, HIST1H4I, IL21R,  POU2AF1, ARHH, EIF4A2, SFRS3"""	"""NHL, CLL"""								20	45					0	0	1	0	0
SMARCA2	6595	broad.mit.edu	37	9	2039582	2039582	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:2039582C>T	ENST00000382203.1	+	4	681	c.472C>T	c.(472-474)Cca>Tca	p.P158S	SMARCA2_ENST00000349721.2_Missense_Mutation_p.P158S|SMARCA2_ENST00000357248.2_Missense_Mutation_p.P158S|SMARCA2_ENST00000382194.1_Missense_Mutation_p.P158S|SMARCA2_ENST00000491574.1_3'UTR			P51531	SMCA2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	158					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		GGCCCTCATCCCAGGTGATCC	0.582000													21	54					0	0	1	0	0
GID8	54994	broad.mit.edu	37	20	61574527	61574527	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:61574527C>T	ENST00000266069.3	+	3	454	c.307C>T	c.(307-309)Cat>Tat	p.H103Y		NM_017896.2	NP_060366.1			GID complex subunit 8																		TCTTTACTTCCATTTGCAGGT	0.418000													8	19					0	0	1	0	0
ASPM	259266	broad.mit.edu	37	1	197102509	197102509	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:197102509C>T	ENST00000367409.4	-	6	2646	c.2390G>A	c.(2389-2391)cGa>cAa	p.R797Q	ASPM_ENST00000294732.7_Missense_Mutation_p.R797Q|ASPM_ENST00000367408.1_Missense_Mutation_p.R47Q	NM_018136.4	NP_060606.3	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle) homolog, microcephaly associated (Drosophila)	797					mitosis	cytoplasm|nucleus	calmodulin binding			breast(6)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(9)|large_intestine(28)|liver(1)|lung(87)|ovary(5)|pancreas(2)|prostate(6)|skin(4)|urinary_tract(3)	165						TCTATCTTTTCGAACAATTAA	0.348000													9	12					0	0	1	0	0
C1QB	713	broad.mit.edu	37	1	22987647	22987647	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:22987647G>A	ENST00000509305.1	+	3	870	c.524G>A	c.(523-525)cGa>cAa	p.R175Q	C1QB_ENST00000314933.6_Missense_Mutation_p.R177Q			P02746	C1QB_HUMAN	complement component 1, q subcomponent, B chain	177	C1q.				complement activation, classical pathway|innate immune response	collagen|complement component C1 complex				breast(1)|endometrium(2)|large_intestine(1)|lung(9)|prostate(1)	14		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.06e-27)|Colorectal(126;1.58e-07)|GBM - Glioblastoma multiforme(114;6.72e-06)|COAD - Colon adenocarcinoma(152;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000551)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.198)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	GCCAGCTCTCGAGGGAACCTG	0.567000													17	39					0	0	1	0	0
STXBP5L	9515	broad.mit.edu	37	3	120833873	120833873	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:120833873G>A	ENST00000273666.6	+	6	843	c.572G>A	c.(571-573)gGa>gAa	p.G191E	STXBP5L_ENST00000497029.1_Missense_Mutation_p.G191E|STXBP5L_ENST00000472879.1_Missense_Mutation_p.G191E|STXBP5L_ENST00000471454.1_Missense_Mutation_p.G191E|STXBP5L_ENST00000492541.1_Missense_Mutation_p.G191E	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	191					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		ATTCTTTCTGGATATGTTATC	0.318000													11	21					0	0	1	0	0
MDM1	56890	broad.mit.edu	37	12	68707276	68707276	+	Nonsense_Mutation	SNP	T	T	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:68707276T>A	ENST00000303145.7	-	11	1752	c.1666A>T	c.(1666-1668)Aaa>Taa	p.K556*	MDM1_ENST00000411698.2_Nonsense_Mutation_p.K521*|MDM1_ENST00000540418.1_Nonsense_Mutation_p.K276*	NM_017440.4	NP_059136.2	Q8TC05	MDM1_HUMAN	Mdm1 nuclear protein homolog (mouse)	556						nucleus				breast(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(7)	33			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000174)		GTCATTCTTTTCCTCTGTTCT	0.353000													16	17					0	0	1	0	0
FANCM	57697	broad.mit.edu	37	14	45644818	45644818	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:45644818C>T	ENST00000267430.5	+	14	2946	c.2861C>T	c.(2860-2862)tCt>tTt	p.S954F	FANCM_ENST00000542564.2_Missense_Mutation_p.S928F	NM_020937.2	NP_065988.1	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	954					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(31)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	85						GATGAAAAATCTGTTTCATCT	0.303000								Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				9	25					0	0	1	0	0
OR4C46	119749	broad.mit.edu	37	11	51515851	51515851	+	Silent	SNP	C	C	T	rs140080586		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:51515851C>T	ENST00000328188.1	+	1	570	c.570C>T	c.(568-570)acC>acT	p.T190T		NM_001004703.1	NP_001004703.1	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C, member 46	190					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|large_intestine(5)|lung(31)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	48						GCACTGACACCCATATGCTGG	0.458000													28	42					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72991843	72991843	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:72991843G>A	ENST00000268489.5	-	2	2874	c.2202C>T	c.(2200-2202)tcC>tcT	p.S734S	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	734					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				TGGTAGTTGTGGAGTAGTTAC	0.557000													26	55					0	0	1	0	0
PIP5K1A	8394	broad.mit.edu	37	1	151214995	151214995	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:151214995C>T	ENST00000409426.1	+	13	2001	c.1556C>T	c.(1555-1557)cCc>cTc	p.P519L	PIP5K1A_ENST00000368888.4_Missense_Mutation_p.P531L|PIP5K1A_ENST00000368890.4_Missense_Mutation_p.P469L|PIP5K1A_ENST00000441902.2_Missense_Mutation_p.P491L|PIP5K1A_ENST00000414290.2_Intron			Q99755	PI51A_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, alpha	531					phospholipid biosynthetic process|signal transduction	endomembrane system|Golgi stack|lamellipodium|nuclear speck	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|kinase binding			breast(1)|central_nervous_system(1)|ovary(1)|skin(1)|stomach(1)	5	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.181)			ATTCCTGACCCCAGTTTCTCA	0.448000													20	37					0	0	1	0	0
ESCO1	114799	broad.mit.edu	37	18	19153318	19153318	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:19153318A>G	ENST00000269214.5	-	4	2424	c.1487T>C	c.(1486-1488)tTg>tCg	p.L496S		NM_052911.2	NP_443143.2	Q5FWF5	ESCO1_HUMAN	establishment of sister chromatid cohesion N-acetyltransferase 1	496					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			breast(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(11)|lung(10)|prostate(3)|upper_aerodigestive_tract(1)	35						CTGATTATCCAATGGTGGGTC	0.318000													15	47					0	0	1	0	0
LILRA4	23547	broad.mit.edu	37	19	54849240	54849240	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:54849240C>T	ENST00000291759.4	-	4	678	c.622G>A	c.(622-624)Gaa>Aaa	p.E208K		NM_012276.3	NP_036408.3	P59901	LIRA4_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4	208	Ig-like C2-type 2.					integral to membrane	receptor activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(13)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	32	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0565)		TCACTGGGTTCCGACCACACG	0.557000													8	20					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152779954	152779954	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:152779954C>T	ENST00000367255.5	-	22	3107	c.2506G>A	c.(2506-2508)Gaa>Aaa	p.E836K	SYNE1_ENST00000367253.4_Missense_Mutation_p.E836K|SYNE1_ENST00000495090.2_Missense_Mutation_p.E403K|SYNE1_ENST00000423061.1_Missense_Mutation_p.E843K|SYNE1_ENST00000413186.2_Missense_Mutation_p.E836K|SYNE1_ENST00000265368.4_Missense_Mutation_p.E836K|SYNE1_ENST00000448038.1_Missense_Mutation_p.E843K|SYNE1_ENST00000341594.5_Missense_Mutation_p.E843K|SYNE1_ENST00000367248.3_Missense_Mutation_p.E826K	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	836					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTGATAATTTCATTGATTTTC	0.398000										HNSCC(10;0.0054)			21	14					0	0	1	0	0
KIF2B	84643	broad.mit.edu	37	17	51900977	51900977	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:51900977C>T	ENST00000268919.4	+	1	739	c.583C>T	c.(583-585)Cgc>Tgc	p.R195C		NM_032559.4	NP_115948.4	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	195					blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(15)|lung(58)|ovary(5)|prostate(4)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	104						CGAAGAGTATCGCAGGCACCT	0.577000													16	30					0	0	1	0	0
CDH9	1007	broad.mit.edu	37	5	26881369	26881369	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:26881369G>A	ENST00000231021.4	-	12	2418	c.2246C>T	c.(2245-2247)tCg>tTg	p.S749L		NM_016279.3	NP_057363.3	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 (T1-cadherin)	749					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(25)|lung(80)|ovary(5)|prostate(4)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	137						AGAACTGAGCGAATCTGCTAT	0.443000													24	35					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45303877	45303877	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:45303877G>A	ENST00000303230.4	-	6	1499	c.1442C>T	c.(1441-1443)cCt>cTt	p.P481L		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	481						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						CACAAAATTAGGATCCGCATT	0.388000													29	48					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153697286	153697286	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:153697286C>T	ENST00000369682.3	+	25	4583	c.4408C>T	c.(4408-4410)Cgt>Tgt	p.R1470C		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	1470					axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CAAGCTCATCCGTCAGCAGAT	0.617000													28	34					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123593820	123593820	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:123593820G>A	ENST00000340011.5	+	3	553	c.196G>A	c.(196-198)Gag>Aag	p.E66K	SPAM1_ENST00000402183.2_Missense_Mutation_p.E66K|SPAM1_ENST00000439500.1_Missense_Mutation_p.E66K|SPAM1_ENST00000460182.1_Missense_Mutation_p.E66K|SPAM1_ENST00000223028.7_Missense_Mutation_p.E66K	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	66					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	AAAATTTGATGAGCCACTAGA	0.438000													15	23					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215916657	215916657	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:215916657G>A	ENST00000366943.2	-	59	11796	c.11410C>T	c.(11410-11412)Cct>Tct	p.P3804S	USH2A_ENST00000307340.3_Missense_Mutation_p.P3804S			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	3804	Fibronectin type-III 23.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding	p.P3804S(1)		NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TACTCCACAGGAATTTCGGGG	0.403000										HNSCC(13;0.011)			11	36					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73066500	73066500	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:73066500G>A	ENST00000429829.1	-	0	6088					NR_001564.2																						TGCTGGAAGGGAAAAGTGGGG	0.473000													18	25					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3661037	3661037	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:3661037G>A	ENST00000263087.4	-	9	1081	c.983C>T	c.(982-984)tCc>tTc	p.S328F		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	328	VWFA.				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		CATTTTGGGGGAGTTGATGAC	0.587000													99	40					0	0	1	0	0
OR13C5	138799	broad.mit.edu	37	9	107361691	107361691	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:107361691C>T	ENST00000374779.2	-	1	97	c.4G>A	c.(4-6)Gaa>Aaa	p.E2K		NM_001004482.1	NP_001004482.1	Q8NGS8	O13C5_HUMAN	olfactory receptor, family 13, subfamily C, member 5	2					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(4)	28						TTTTCCCATTCCATTTTACTC	0.363000													16	7					0	0	1	0	0
HSPA4	3308	broad.mit.edu	37	5	132425303	132425303	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:132425303C>T	ENST00000304858.2	+	11	1583	c.1294C>T	c.(1294-1296)Ctt>Ttt	p.L432F		NM_002154.3	NP_002145.3	P34932	HSP74_HUMAN	heat shock 70kDa protein 4	432					cellular chaperone-mediated protein complex assembly|protein import into mitochondrial outer membrane|response to unfolded protein	cytoplasm|nucleus	ATP binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(10)|stomach(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTCTAAAGTTCTTACATTTTA	0.388000													6	12					0	0	1	0	0
CHRNB3	1142	broad.mit.edu	37	8	42586954	42586954	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:42586954C>T	ENST00000289957.2	+	5	632	c.504C>T	c.(502-504)tcC>tcT	p.S168S		NM_000749.3	NP_000740.1	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta 3 (neuronal)	168					synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			endometrium(4)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			AGAACTGCTCCATGAAGTTTG	0.478000													9	21					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101609019	101609019	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:101609019G>A	ENST00000311812.2	-	10	976	c.826C>T	c.(826-828)Cct>Tct	p.P276S	SNX31_ENST00000428383.2_Missense_Mutation_p.P177S	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	276					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			CAGGTACAAGGATCCAGCTGC	0.552000													31	62					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179579898	179579898	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:179579898A>T	ENST00000589042.1	-	90	26239	c.26015T>A	c.(26014-26016)tTt>tAt	p.F8672Y	TTN_ENST00000591111.1_Missense_Mutation_p.F8355Y|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.F7428Y	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	8355	Ig-like 69.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGAAACGTGAAATGGGGGAGT	0.433000													40	21					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2163267	2163267	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:2163267G>A	ENST00000262304.4	-	12	3088	c.2880C>T	c.(2878-2880)ggC>ggT	p.G960G	RP11-304L19.4_ENST00000568795.1_RNA|PKD1_ENST00000423118.1_Silent_p.G960G	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	960	PKD 4.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						CCATGTCCGAGCCGGCCTCCA	0.607000													31	59					0	0	1	0	0
KANSL1	284058	broad.mit.edu	37	17	44109471	44109471	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:44109471C>T	ENST00000262419.6	-	14	3502	c.3032G>A	c.(3031-3033)cGa>cAa	p.R1011Q	KANSL1_ENST00000575318.1_Missense_Mutation_p.R947Q|KANSL1_ENST00000432791.1_Missense_Mutation_p.R1011Q|KANSL1_ENST00000393476.3_Missense_Mutation_p.R305Q|KANSL1_ENST00000574590.1_Missense_Mutation_p.R1011Q|KANSL1_ENST00000572904.1_Missense_Mutation_p.R1011Q	NM_001193466.1	NP_001180395.1	Q7Z3B3	K1267_HUMAN	KAT8 regulatory NSL complex subunit 1	1011						MLL1 complex	protein binding										GGCTAAGTGTCGCGGAGTGTC	0.602000													19	41					0	0	1	0	0
C10orf54	64115	broad.mit.edu	37	10	73511467	73511467	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:73511467G>A	ENST00000394957.3	-	6	914	c.856C>T	c.(856-858)Ctg>Ttg	p.L286L	CDH23_ENST00000224721.6_Intron	NM_022153.1	NP_071436.1	Q9H7M9	GI24_HUMAN	chromosome 10 open reading frame 54	286						integral to membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	9						GGAGGAGACAGGGGGGTGCTG	0.617000													10	4					0	0	1	0	0
MGAT3	4248	broad.mit.edu	37	22	39884006	39884006	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:39884006C>T	ENST00000341184.6	+	2	869	c.654C>T	c.(652-654)ttC>ttT	p.F218F		NM_001098270.1|NM_002409.4	NP_001091740.1|NP_002400.3	Q09327	MGAT3_HUMAN	mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase	218					post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	p.F218F(1)		endometrium(4)|kidney(1)|large_intestine(5)|lung(12)|prostate(1)|skin(1)	24	Melanoma(58;0.04)					ACCACGAGTTCGACCTGCTGG	0.652000													9	35					0	0	1	0	0
ABCC6P1	653190	broad.mit.edu	37	16	18597254	18597254	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:18597254C>T	ENST00000546162.2	+	0	994					NR_003569.1																						GCAGTGCAGCCCGGGGGTAAG	0.552000													30	48					0	0	1	0	0
NLGN4X	57502	broad.mit.edu	37	X	6069227	6069227	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:6069227G>A	ENST00000381095.3	-	2	908	c.281C>T	c.(280-282)cCg>cTg	p.P94L	NLGN4X_ENST00000469740.1_5'UTR|NLGN4X_ENST00000538097.1_Missense_Mutation_p.P94L|NLGN4X_ENST00000381093.2_Missense_Mutation_p.P94L|NLGN4X_ENST00000381092.1_Missense_Mutation_p.P94L|NLGN4X_ENST00000275857.6_Missense_Mutation_p.P94L	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	94					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						CCAGGAGGACGGGGGTTCTGG	0.582000													10	35					0	0	1	0	0
GABRB2	2561	broad.mit.edu	37	5	160758022	160758022	+	Silent	SNP	G	G	A	rs79319310		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:160758022G>A	ENST00000274547.2	-	9	1162	c.945C>T	c.(943-945)ttC>ttT	p.F315F	GABRB2_ENST00000520240.1_Silent_p.F315F|GABRB2_ENST00000517547.1_Silent_p.F155F|GABRB2_ENST00000517901.1_Silent_p.F252F|GABRB2_ENST00000353437.6_Silent_p.F315F|GABRB2_ENST00000393959.1_Silent_p.F315F	NM_000813.2|NM_021911.2	NP_000804.1|NP_068711.1	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 2	315					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	CCATGAAAACGAAGACAAAGC	0.512000													22	33					0	0	1	0	0
ELMO2	63916	broad.mit.edu	37	20	45023111	45023111	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:45023111G>A	ENST00000290246.6	-	3	205	c.11C>T	c.(10-12)cCg>cTg	p.P4L	ELMO2_ENST00000439931.2_Missense_Mutation_p.P4L|ELMO2_ENST00000372176.1_5'UTR|ELMO2_ENST00000352077.2_Missense_Mutation_p.P4L|ELMO2_ENST00000488853.1_5'UTR|ELMO2_ENST00000445496.2_5'UTR|ELMO2_ENST00000396391.1_Missense_Mutation_p.P4L	NM_133171.3	NP_573403.1	Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	4					apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			breast(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|urinary_tract(1)	16		Myeloproliferative disorder(115;0.0122)				AATGTCTGACGGTGGTGGCAT	0.502000													10	22					0	0	1	0	0
DOCK11	139818	broad.mit.edu	37	X	117706351	117706351	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:117706351C>T	ENST00000276204.6	+	11	1175	c.1101C>T	c.(1099-1101)ttC>ttT	p.F367F	DOCK11_ENST00000276202.7_Silent_p.F367F			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	367					blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						ATAAACGTTTCCTGGTGAATT	0.348000													29	38					0	0	1	0	0
TRAJ23	28732	broad.mit.edu	37	14	22989426	22989426	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:22989426G>A	ENST00000390514.1	+	0	33																											GCTTATCTTCGGACAGGGAAC	0.413000													10	25					0	0	1	0	0
SLC27A5	10998	broad.mit.edu	37	19	59011961	59011961	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:59011961T>C	ENST00000263093.2	-	5	1404	c.1295A>G	c.(1294-1296)tAc>tGc	p.Y432C	SLC27A5_ENST00000601355.1_Missense_Mutation_p.Y348C	NM_012254.2	NP_036386.1	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid transporter), member 5	432					bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		TGTGGAGCCGTAGACTTCCCA	0.602000													15	25					0	0	1	0	0
NAA25	80018	broad.mit.edu	37	12	112492208	112492208	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:112492208G>T	ENST00000261745.4	-	14	1860	c.1612C>A	c.(1612-1614)Cag>Aag	p.Q538K		NM_024953.3	NP_079229.2	Q14CX7	NAA25_HUMAN	N(alpha)-acetyltransferase 25, NatB auxiliary subunit	538						cytoplasm	protein binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(1)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	46						GTATCATGCTGGATATGCTTA	0.428000													11	21					2.27111e-07	2.28873e-07	1	1	0
KCNS3	3790	broad.mit.edu	37	2	18113687	18113687	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:18113687C>T	ENST00000403915.1	+	3	1863	c.1412C>T	c.(1411-1413)tCa>tTa	p.S471L	KCNS3_ENST00000465292.1_Intron|KCNS3_ENST00000304101.4_Missense_Mutation_p.S471L			Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3	471					energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			endometrium(5)|kidney(1)|large_intestine(7)|lung(11)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					ACAGATGCTTCAAGCATTGAA	0.453000													18	12					0	0	1	0	0
ABCF3	55324	broad.mit.edu	37	3	183907652	183907652	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:183907652G>A	ENST00000429586.2	+	14	1509	c.1324G>A	c.(1324-1326)Gac>Aac	p.D442N	ABCF3_ENST00000292808.5_Missense_Mutation_p.D436N|EIF2B5_ENST00000444495.1_Intron	NM_018358.2	NP_060828.2	Q9NUQ8	ABCF3_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 3	442							ATP binding|ATPase activity	p.D442N(1)		breast(2)|cervix(1)|endometrium(2)|large_intestine(5)|lung(20)|ovary(3)|prostate(5)|upper_aerodigestive_tract(1)	39	all_cancers(143;1.12e-10)|Ovarian(172;0.0339)		Epithelial(37;2.35e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GGTTTTCATTGACCGGTTTCG	0.572000													20	29					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124293344	124293344	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:124293344G>A	ENST00000409039.3	+	18	2659	c.2633_splice	c.e18-1	p.K878_splice		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	878	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CCCCTCTTAGGAACTTGCAGT	0.433000													58	101					0	0	1	0	0
KALRN	8997	broad.mit.edu	37	3	124420920	124420920	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:124420920G>A	ENST00000360013.3	+	57	8159	c.8032G>A	c.(8032-8034)Gaa>Aaa	p.E2678K	KALRN_ENST00000291478.4_Missense_Mutation_p.E981K|KALRN_ENST00000428018.2_Missense_Mutation_p.E949K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2677					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						TTCTTGGAAGGAAAATTTTGA	0.358000													16	22					0	0	1	0	0
DGKI	9162	broad.mit.edu	37	7	137271862	137271862	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:137271862C>T	ENST00000453654.1	-	13	1045	c.506G>A	c.(505-507)cGa>cAa	p.R169Q	DGKI_ENST00000288490.5_Missense_Mutation_p.R469Q|DGKI_ENST00000446122.1_Missense_Mutation_p.R469Q|DGKI_ENST00000424189.2_Missense_Mutation_p.R469Q			O75912	DGKI_HUMAN	diacylglycerol kinase, iota	469					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(46)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	84						GTTGAGAGTTCGAGCCAGGTC	0.552000													22	31					0	0	1	0	0
RNF4	6047	broad.mit.edu	37	4	2515513	2515513	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:2515513C>T	ENST00000511600.1	+	8	2055	c.540C>T	c.(538-540)atC>atT	p.I180I	RNF4_ENST00000541204.1_Silent_p.I180I|RNF4_ENST00000314289.8_Silent_p.I180I|RNF4_ENST00000506706.1_Silent_p.I180I|RNF4_ENST00000511859.1_3'UTR			P78317	RNF4_HUMAN	ring finger protein 4	180					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|proteasomal ubiquitin-dependent protein catabolic process|protein autoubiquitination|protein K11-linked ubiquitination|protein K48-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination|regulation of kinetochore assembly|regulation of spindle assembly|response to arsenic-containing substance	cytoplasm|PML body	androgen receptor binding|DNA binding|nucleosome binding|sequence-specific DNA binding transcription factor activity|SUMO polymer binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			endometrium(2)|kidney(2)|lung(1)	5		all_epithelial(65;0.241)				GGAAAAAGATCAACCACAAAC	0.493000													31	30					0	0	1	0	0
NEFM	4741	broad.mit.edu	37	8	24775487	24775487	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:24775487A>T	ENST00000221166.5	+	3	2901	c.2119A>T	c.(2119-2121)Aag>Tag	p.K707*	NEFM_ENST00000518131.1_Intron|NEFM_ENST00000437366.2_Nonsense_Mutation_p.K668*|NEFM_ENST00000433454.2_Nonsense_Mutation_p.K331*|NEFM_ENST00000521540.1_Intron			P07197	NFM_HUMAN	neurofilament, medium polypeptide	707	Tail.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(3)|endometrium(7)|kidney(4)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|urinary_tract(1)	36		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		ggaagaagaaaaggaagtcaa	0.453000													3	4					0	0	1	0	0
FOXRED2	80020	broad.mit.edu	37	22	36897341	36897341	+	Missense_Mutation	SNP	G	G	A	rs147376195		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:36897341G>A	ENST00000397224.4	-	5	1256	c.1163C>T	c.(1162-1164)tCg>tTg	p.S388L	FOXRED2_ENST00000397223.4_Missense_Mutation_p.S388L|FOXRED2_ENST00000216187.6_Missense_Mutation_p.S388L	NM_001102371.1	NP_001095841.1	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	388					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22						GTAGTCCACCGAGTGGCTGGC	0.557000													33	31					0	0	1	0	0
COL13A1	1305	broad.mit.edu	37	10	71654431	71654431	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:71654431G>A	ENST00000356340.3	+	10	1140	c.603_splice	c.e10-1	p.G202_splice	COL13A1_ENST00000398966.3_Splice_Site_p.G202_splice|COL13A1_ENST00000398972.3_Splice_Site_p.G202_splice|COL13A1_ENST00000354547.3_Splice_Site_p.G202_splice|COL13A1_ENST00000398974.3_Splice_Site_p.G190_splice|COL13A1_ENST00000520133.1_Splice_Site_p.G173_splice|COL13A1_ENST00000398969.3_Splice_Site_p.G164_splice|COL13A1_ENST00000398964.3_Splice_Site_p.G173_splice|COL13A1_ENST00000517713.1_Splice_Site_p.G202_splice|COL13A1_ENST00000357811.3_Splice_Site_p.G202_splice|COL13A1_ENST00000520267.1_Splice_Site_p.G164_splice|COL13A1_ENST00000398973.3_Splice_Site_p.G202_splice|COL13A1_ENST00000398971.3_Splice_Site_p.G202_splice|COL13A1_ENST00000398968.3_Splice_Site_p.G202_splice|COL13A1_ENST00000398978.3_Splice_Site_p.G202_splice|COL13A1_ENST00000522165.1_Splice_Site_p.G202_splice			Q5TAT6	CODA1_HUMAN	collagen, type XIII, alpha 1	202	Triple-helical region 1 (COL1).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			endometrium(5)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	28					Atorvastatin(DB01076)|Simvastatin(DB00641)	CTCTTTGTAGGGACCCCAGGG	0.498000													11	9					0	0	1	0	0
ATAD3C	219293	broad.mit.edu	37	1	1389812	1389812	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:1389812G>A	ENST00000378785.2	+	4	1305	c.310G>A	c.(310-312)Ggg>Agg	p.G104R		NM_001039211.2	NP_001034300.2	Q5T2N8	ATD3C_HUMAN	ATPase family, AAA domain containing 3C	104							ATP binding|nucleoside-triphosphatase activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|lung(4)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.79e-36)|OV - Ovarian serous cystadenocarcinoma(86;3.94e-22)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.145)		GGCTCGGCTGGGGAAGCCGTC	0.677000													6	4					0	0	1	0	0
C16orf78	123970	broad.mit.edu	37	16	49430390	49430390	+	Missense_Mutation	SNP	C	C	T	rs146394582		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:49430390C>T	ENST00000299191.3	+	4	568	c.451C>T	c.(451-453)Cgt>Tgt	p.R151C		NM_144602.2	NP_653203.1	Q8WTQ4	CP078_HUMAN	chromosome 16 open reading frame 78	151										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|upper_aerodigestive_tract(1)	22						AAACCCATTCCGTCGACAAAG	0.493000													12	23					0	0	1	0	0
CFI	3426	broad.mit.edu	37	4	110662121	110662121	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:110662121G>A	ENST00000394634.2	-	13	1887	c.1680C>T	c.(1678-1680)acC>acT	p.T560T	CFI_ENST00000512148.1_Silent_p.T553T|CFI_ENST00000394635.3_Silent_p.T568T	NM_000204.3	NP_000195.2	P05156	CFAI_HUMAN	complement factor I	560	Peptidase S1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular space|membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|skin(2)|stomach(1)	27		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000331)		TGGCCACTTTGGTGTAAACAC	0.418000													56	73					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197404341	197404341	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:197404341C>T	ENST00000367397.1	+	5	2349	c.1491C>T	c.(1489-1491)ttC>ttT	p.F497F	CRB1_ENST00000367400.3_Silent_p.F1116F|CRB1_ENST00000367399.2_Silent_p.F1004F|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000535699.1_Silent_p.F1092F|CRB1_ENST00000544212.1_Silent_p.F597F			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1116	Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						TTCATGGTTTCATTAATAAAC	0.398000													19	28					0	0	1	0	0
VCAN	1462	broad.mit.edu	37	5	82817840	82817840	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:82817840G>A	ENST00000265077.3	+	7	4280	c.3715G>A	c.(3715-3717)Gaa>Aaa	p.E1239K	VCAN_ENST00000342785.4_Missense_Mutation_p.E1239K|VCAN_ENST00000502527.2_Intron|VCAN_ENST00000512590.2_Missense_Mutation_p.E1191K|VCAN_ENST00000343200.5_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1239	GAG-alpha (glucosaminoglycan attachment domain).				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CATCGACAGGGAACCTGGTGA	0.443000													23	22					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179584856	179584856	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:179584856T>A	ENST00000589042.1	-	81	23737	c.23513A>T	c.(23512-23514)gAg>gTg	p.E7838V	TTN_ENST00000591111.1_Missense_Mutation_p.E7521V|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.E6594V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7521	Ig-like 60.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTTCACTCTCTCTGATGAC	0.433000													17	4					0	0	1	0	0
MIR519A2	574500	broad.mit.edu	37	19	54265621	54265621	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:54265621G>A	ENST00000384990.1	+	0	24					NR_030222.1																						CCCTCTACAGGGAAGCGCTTT	0.413000													41	64					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40265894	40265894	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:40265894A>C	ENST00000263791.5	+	11	1805	c.1762A>C	c.(1762-1764)Att>Ctt	p.I588L	EIF2AK4_ENST00000382727.2_Missense_Mutation_p.I588L|EIF2AK4_ENST00000559624.1_Missense_Mutation_p.I588L	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	588					translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CCGATACTTCATTGAGTTTGA	0.443000													37	40					0	0	1	0	0
TRIP4	9325	broad.mit.edu	37	15	64717750	64717750	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:64717750C>T	ENST00000261884.3	+	11	1555	c.1495C>T	c.(1495-1497)Cct>Tct	p.P499S		NM_016213.4	NP_057297.2	Q15650	TRIP4_HUMAN	thyroid hormone receptor interactor 4	499					positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleus	ligand-dependent nuclear receptor binding|transcription coactivator activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21						TGTGGAATTTCCTAATGACTA	0.363000													11	33					0	0	1	0	0
SSPO	23145	broad.mit.edu	37	7	149489531	149489531	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:149489531G>A	ENST00000378016.2	+	0	5684							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TGCCAAGACGGACGGCCCCGA	0.692000													12	11					0	0	1	0	0
IGHA1	3493	broad.mit.edu	37	14	106173632	106173632	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:106173632G>A	ENST00000390547.2	-	0	934																											CACCATGCAGGAGAAGGTGTC	0.632000													11	57					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9077720	9077720	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:9077720C>T	ENST00000397910.4	-	3	9929	c.9726G>A	c.(9724-9726)gtG>gtA	p.V3242V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3243	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGACTGGTTCCACTGTGGTCT	0.532000													46	57					0	0	1	0	0
EIF2D	1939	broad.mit.edu	37	1	206772888	206772888	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:206772888G>A	ENST00000271764.2	-	10	1339	c.1131C>T	c.(1129-1131)caC>caT	p.H377H	EIF2D_ENST00000367114.3_Silent_p.H253H	NM_006893.2	NP_008824.2	P41214	EIF2D_HUMAN	eukaryotic translation initiation factor 2D	377					intracellular protein transport	cytoplasm	protein binding|receptor activity|translation initiation factor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	23						TATCTGGAGGGTGATAGGGCT	0.542000													20	33					0	0	1	0	0
OR52E2	119678	broad.mit.edu	37	11	5080594	5080594	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:5080594C>T	ENST00000321522.2	-	1	263	c.264G>A	c.(262-264)tgG>tgA	p.W88*		NM_001005164.2	NP_001005164.2	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E, member 2	88					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.W88*(1)		endometrium(2)|lung(13)|ovary(2)|skin(3)	20		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		TGAGGTTGATCCAGAAGATTC	0.498000													8	12					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32630123	32630123	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:32630123C>T	ENST00000242310.4	-	1	5544	c.5455G>A	c.(5455-5457)Gaa>Aaa	p.E1819K		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1819					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TCCTTGTGTTCTCCTGAAGCA	0.478000													14	20					0	0	1	0	0
COL28A1	340267	broad.mit.edu	37	7	7412718	7412718	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:7412718G>A	ENST00000399429.3	-	32	2959	c.2819C>T	c.(2818-2820)cCc>cTc	p.P940L		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	940	VWFA 2.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		TTCAAAGTTGGGATCATTTTT	0.403000													18	24					0	0	1	0	0
MIB1	57534	broad.mit.edu	37	18	19353597	19353597	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:19353597C>T	ENST00000261537.6	+	4	808	c.544C>T	c.(544-546)Cag>Tag	p.Q182*	MIB1_ENST00000578646.1_3'UTR	NM_020774.2	NP_065825.1	Q86YT6	MIB1_HUMAN	mindbomb E3 ubiquitin protein ligase 1	182	MIB/HERC2 2.				Notch signaling pathway	centrosome|nuclear membrane|plasma membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|ovary(5)	27			STAD - Stomach adenocarcinoma(5;0.212)			AACAGAAATCCAGGACTGGAG	0.378000													9	11					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155200466	155200466	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:155200466C>T	ENST00000460012.1	-	23	3616	c.3259G>A	c.(3259-3261)Gga>Aga	p.G1087R	PLCH1_ENST00000447496.2_3'UTR|PLCH1_ENST00000340059.7_Missense_Mutation_p.G1125R|PLCH1_ENST00000334686.6_Missense_Mutation_p.G1087R|PLCH1_ENST00000414191.1_Missense_Mutation_p.G1087R|PLCH1_ENST00000494598.1_Intron			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	1125					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			AGGACGCTTCCTGACAAGATG	0.458000													21	25					0	0	1	0	0
BRCA2	675	broad.mit.edu	37	13	32911141	32911141	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:32911141C>T	ENST00000544455.1	+	11	2876	c.2649C>T	c.(2647-2649)ttC>ttT	p.F883F	BRCA2_ENST00000380152.3_Silent_p.F883F	NM_000059.3	NP_000050.2	P51587	BRCA2_HUMAN	breast cancer 2, early onset	883	Interaction with NPM1.				cell cycle cytokinesis|centrosome duplication|double-strand break repair via homologous recombination|negative regulation of mammary gland epithelial cell proliferation|nucleotide-excision repair|positive regulation of transcription, DNA-dependent|regulation of S phase of mitotic cell cycle	BRCA2-MAGE-D1 complex|centrosome|nucleoplasm|stored secretory granule	gamma-tubulin binding|H3 histone acetyltransferase activity|H4 histone acetyltransferase activity|protease binding|single-stranded DNA binding			NS(3)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(32)|liver(1)|lung(41)|oesophagus(5)|ovary(22)|pancreas(4)|prostate(3)|salivary_gland(1)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	183		Lung SC(185;0.0262)		all cancers(112;7.13e-07)|Epithelial(112;1.59e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000732)|BRCA - Breast invasive adenocarcinoma(63;0.0291)|GBM - Glioblastoma multiforme(144;0.0704)		AAGAACTTTTCTCAGACAATG	0.308000			"""D, Mis, N, F, S"""		"""breast, ovarian, pancreatic"""	"""breast, ovarian, pancreatic, leukemia  (FANCB, FANCD1)"""		Homologous recombination	Pancreatic Cancer, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Prostate Cancer;Hereditary Breast-Ovarian Cancer, BRCA2 type;Fanconi Anemia type D1, bi-allelic BRCA2 mutations;Fanconi Anemia	TCGA Ovarian(8;0.087)			11	34					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20946802	20946802	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:20946802C>T	ENST00000261383.3	-	61	11864	c.11865G>A	c.(11863-11865)tgG>tgA	p.W3955*	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3955					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CCTTGTCAATCCATTCCTGGA	0.383000													9	11					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42635279	42635279	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:42635279G>A	ENST00000358131.5	+	3	493	c.285G>A	c.(283-285)ggG>ggA	p.G95G	TOX2_ENST00000423191.1_Silent_p.G44G|TOX2_ENST00000341197.3_Silent_p.G86G|TOX2_ENST00000372999.1_Silent_p.G44G	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	95	Required for transcriptional activation (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			TGCACCTGGGGGACCACGAAG	0.607000													18	35					0	0	1	0	0
CDC5L	988	broad.mit.edu	37	6	44364086	44364086	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:44364086G>A	ENST00000371477.3	+	5	747	c.448G>A	c.(448-450)Gag>Aag	p.E150K		NM_001253.3	NP_001244.1	Q99459	CDC5L_HUMAN	cell division cycle 5-like	150					cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|cytoplasm|nuclear speck|nucleolus	DNA binding|RNA binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(14)|ovary(1)|skin(4)	29	all_lung(25;0.00433)|Ovarian(13;0.0273)|all_hematologic(164;0.208)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AGATGAACTTGAGATGCTTTC	0.383000													18	43					0	0	1	0	0
POM121C	100101267	broad.mit.edu	37	7	75051376	75051376	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:75051376G>C	ENST00000453279.2	-	13	3023	c.2159C>G	c.(2158-2160)cCa>cGa	p.P720R	POM121C_ENST00000257665.5_Missense_Mutation_p.P962R	NM_001099415.1	NP_001092885.1	A8CG34	P121C_HUMAN	POM121 transmembrane nucleoporin C	962	Pore side (Potential).			P -> L (in Ref. 2; BC082993).	mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	14						GGTAAGGGCTGGCTTGGCGGC	0.657000													8	20					0	0	1	0	0
DRP2	1821	broad.mit.edu	37	X	100490865	100490865	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:100490865C>T	ENST00000395209.3	+	4	661	c.134C>T	c.(133-135)aCc>aTc	p.T45I	DRP2_ENST00000538510.1_Missense_Mutation_p.T45I|DRP2_ENST00000402866.1_Missense_Mutation_p.T45I|DRP2_ENST00000541709.1_5'UTR	NM_001939.2	NP_001930.2	Q13474	DRP2_HUMAN	dystrophin related protein 2	45					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	31						GCTGCTGTCACCAGCCCTGCA	0.562000													36	79					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71508130	71508130	+	Silent	SNP	T	T	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:71508130T>G	ENST00000396073.3	+	9	1268	c.987T>G	c.(985-987)ccT>ccG	p.P329P	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	329					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			GAAATTTTCCTTCAGGAAGAC	0.448000													31	34					0	0	1	0	0
FZD10	11211	broad.mit.edu	37	12	130648492	130648492	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:130648492C>T	ENST00000539839.1	+	1	1489	c.907C>T	c.(907-909)Cct>Tct	p.P303S	FZD10_ENST00000229030.4_Silent_p.F335F	NM_007197.3	NP_009128.1	Q9ULW2	FZD10_HUMAN	frizzled family receptor 10	0					brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|pancreas(1)|prostate(3)|urinary_tract(1)	35	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		TCACCTGGTTCCTGGCCGCCG	0.647000													13	26					0	0	1	0	0
SEMG1	6406	broad.mit.edu	37	20	43836177	43836177	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:43836177G>A	ENST00000372781.3	+	2	296	c.239G>A	c.(238-240)cGa>cAa	p.R80Q	SEMG1_ENST00000244069.6_Missense_Mutation_p.R80Q	NM_003007.3	NP_002998.1			semenogelin I											cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.0122)				GACCAGTCCCGAAAAAGTCAG	0.388000													23	35					0	0	1	0	0
SYNE2	23224	broad.mit.edu	37	14	64599047	64599047	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:64599047C>T	ENST00000357395.3	+	78	14704	c.3560C>T	c.(3559-3561)cCt>cTt	p.P1187L	SYNE2_ENST00000344113.4_Missense_Mutation_p.P4802L|SYNE2_ENST00000555002.1_Missense_Mutation_p.P1436L|SYNE2_ENST00000394768.2_Missense_Mutation_p.P1187L|SYNE2_ENST00000554584.1_Missense_Mutation_p.P4719L|ESR2_ENST00000542956.1_Intron|SYNE2_ENST00000358025.3_Missense_Mutation_p.P4802L			Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4802					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AAAATACTTCCTTCTTTATTG	0.358000													20	41					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9059370	9059370	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:9059370C>T	ENST00000397910.4	-	3	28279	c.28076G>A	c.(28075-28077)aGg>aAg	p.R9359K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9361	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGATTCTTTCCTTGTGAGGGG	0.512000													35	43					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578370	7578370	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:7578370C>T	ENST00000420246.2	-	5	692		c.e5+1		TP53_ENST00000445888.2_Splice_Site|TP53_ENST00000455263.2_Splice_Site|TP53_ENST00000359597.4_Splice_Site|TP53_ENST00000574684.1_Splice_Site|TP53_ENST00000413465.2_Splice_Site|TP53_ENST00000269305.4_Splice_Site	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(54)|p.0?(8)|p.G187fs*16(2)|p.D186_P191delDGLAPP(1)|p.L188fs*19(1)|p.G187_L188delGL(1)|p.G187fs*22(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCTGCTCACCATCGCTATC	0.632000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	8					0	0	1	0	0
MMP2	4313	broad.mit.edu	37	16	55532214	55532214	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:55532214G>A	ENST00000219070.4	+	11	2132	c.1623G>A	c.(1621-1623)tgG>tgA	p.W541*	MMP2_ENST00000437642.2_Nonsense_Mutation_p.W491*|MMP2_ENST00000543485.1_Nonsense_Mutation_p.W465*|MMP2_ENST00000570308.1_Nonsense_Mutation_p.W465*	NM_004530.4	NP_004521.1	P08253	MMP2_HUMAN	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	541	Hemopexin-like 2.|Required for inhibitor TIMP2 binding.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(12)|liver(2)|lung(23)|ovary(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	58		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	ATGAATACTGGATCTACTCAG	0.607000													26	23					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144990869	144990869	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:144990869G>A	ENST00000322810.4	-	32	13700	c.13531C>T	c.(13531-13533)Ctg>Ttg	p.L4511L	PLEC_ENST00000527096.1_Silent_p.L4397L|PLEC_ENST00000398774.2_Silent_p.L4342L|PLEC_ENST00000356346.3_Silent_p.L4360L|PLEC_ENST00000354589.3_Silent_p.L4374L|PLEC_ENST00000354958.2_Silent_p.L4352L|PLEC_ENST00000357649.2_Silent_p.L4378L|PLEC_ENST00000345136.3_Silent_p.L4374L|PLEC_ENST00000436759.2_Silent_p.L4401L	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4511	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CCCTTCTTCAGGGCCTGGGCG	0.667000													16	34					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50985814	50985814	+	Missense_Mutation	SNP	G	G	A	rs150938467	byFrequency	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:50985814G>A	ENST00000442544.2	+	24	4221	c.3605G>A	c.(3604-3606)aGc>aAc	p.S1202N	DCC_ENST00000581580.1_Missense_Mutation_p.S837N	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	1202					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane		p.S1202I(1)		NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GGAAGCAAAAGCACCTCTCAT	0.478000													26	37					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144940318	144940318	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:144940318G>A	ENST00000525985.1	-	2	7175	c.7104C>T	c.(7102-7104)ttC>ttT	p.F2368F				P58107	EPIPL_HUMAN	epiplakin 1	2368						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TCTCCTCGTCGAAGTAGCCGC	0.682000													12	410					0	0	1	0	0
MAGEA10	4109	broad.mit.edu	37	X	151303402	151303402	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:151303402G>A	ENST00000370323.4	-	4	1007	c.691C>T	c.(691-693)Cta>Tta	p.L231L	RP11-1007I13.4_ENST00000509345.2_RNA|MAGEA10_ENST00000244096.3_Silent_p.L231L	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	231	MAGE.									endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					ACTATGCTTAGGATAAGTATG	0.512000													21	19					0	0	1	0	0
RPAP2	79871	broad.mit.edu	37	1	92789349	92789349	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:92789349C>T	ENST00000370343.3	+	8	981	c.872C>T	c.(871-873)cCt>cTt	p.P291L	RPAP2_ENST00000484158.1_3'UTR	NM_024813.2	NP_079089.2	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	291						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	22		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		TGTGAACTTCCTTTACAGAAA	0.363000													21	41					0	0	1	0	0
ALOX5	240	broad.mit.edu	37	10	45920565	45920565	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:45920565G>A	ENST00000374391.2	+	6	872	c.819G>A	c.(817-819)ttG>ttA	p.L273L	ALOX5_ENST00000542434.1_Silent_p.L273L	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	273	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	AGCTCAGCTTGGAGCAGGAGG	0.627000													9	4					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140736453	140736453	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140736453C>T	ENST00000571252.1	+	1	1686	c.1686C>T	c.(1684-1686)atC>atT	p.I562I	PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCCTGAGATCCTGTACCCCA	0.582000													70	109					0	0	1	0	0
LRRFIP1	9208	broad.mit.edu	37	2	238671675	238671675	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:238671675C>T	ENST00000244815.5	+	10	1487	c.1247C>T	c.(1246-1248)tCg>tTg	p.S416L	LRRFIP1_ENST00000289175.6_Missense_Mutation_p.S384L|LRRFIP1_ENST00000392000.4_Missense_Mutation_p.S440L|LRRFIP1_ENST00000308482.9_Intron	NM_004735.3	NP_004726.2	Q32MZ4	LRRF1_HUMAN	leucine rich repeat (in FLII) interacting protein 1	440					negative regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|cytoskeleton|nucleus	DNA binding|double-stranded RNA binding|protein binding			NS(1)|breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	29		Breast(86;0.00257)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;9.75e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.01e-10)|Kidney(56;4.85e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.31e-07)|BRCA - Breast invasive adenocarcinoma(100;0.000151)|Lung(119;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0325)|COAD - Colon adenocarcinoma(134;0.228)		ACAGTGGCCTCGTGTCCTTTA	0.498000													21	13					0	0	1	0	0
ZNF627	199692	broad.mit.edu	37	19	11725687	11725687	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:11725687C>T	ENST00000361113.5	+	3	384	c.176C>T	c.(175-177)cCc>cTc	p.P59L	ZNF627_ENST00000588174.1_Missense_Mutation_p.P59L	NM_145295.3	NP_660338.1	Q7L945	ZN627_HUMAN	zinc finger protein 627	59	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	14						TTCAAAATTCCCAGGAGAAAT	0.289000													3	10					0	0	1	0	0
COPA	1314	broad.mit.edu	37	1	160276187	160276187	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:160276187G>A	ENST00000241704.7	-	15	1628	c.1399C>T	c.(1399-1401)Cga>Tga	p.R467*	COPA_ENST00000368069.3_Nonsense_Mutation_p.R467*	NM_001098398.1|NM_004371.3	NP_001091868.1|NP_004362.2	P53621	COPA_HUMAN	coatomer protein complex, subunit alpha	467					COPI coating of Golgi vesicle|intracellular protein transport|pancreatic juice secretion|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|extracellular space|microsome|soluble fraction	hormone activity|structural molecule activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(2)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	46	all_cancers(52;8.15e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TCCGCATCTCGAAGCAGGAGA	0.493000													27	39					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174385	150174385	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:150174385G>A	ENST00000307271.3	+	5	2089	c.1515G>A	c.(1513-1515)aaG>aaA	p.K505K		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	505						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		ATGTCGAAAAGGACCCATCCC	0.542000													16	19					0	0	1	0	0
CIDEA	1149	broad.mit.edu	37	18	12277249	12277249	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:12277249G>A	ENST00000320477.9	+	5	705	c.640G>A	c.(640-642)Ggc>Agc	p.G214S	CIDEA_ENST00000521296.1_3'UTR	NM_001279.3	NP_001270.1	O60543	CIDEA_HUMAN	cell death-inducing DFFA-like effector a	214					DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change|lipid metabolic process|lipid storage|negative regulation of apoptosis|negative regulation of cytokine secretion|negative regulation of lipid catabolic process|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of tumor necrosis factor production|positive regulation of sequestering of triglyceride|temperature homeostasis	mitochondrial envelope|nucleus	protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|lung(6)|ovary(1)|pancreas(1)|prostate(2)	13						ACAAGCCAAGGGCAGGTTCAC	0.547000													19	25					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28270426	28270426	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:28270426G>A	ENST00000305242.5	-	7	997	c.905C>T	c.(904-906)tCa>tTa	p.S302L	ARMC4_ENST00000480504.1_5'UTR|ARMC4_ENST00000545014.1_5'UTR|ARMC4_ENST00000239715.3_Missense_Mutation_p.S159L|ARMC4_ENST00000537576.1_5'UTR	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	302							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						AAATTTTGGTGATTTTTCTCT	0.294000													18	10					0	0	1	0	0
C11orf53	341032	broad.mit.edu	37	11	111156556	111156556	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:111156556C>T	ENST00000280325.4	+	4	635	c.488C>T	c.(487-489)tCg>tTg	p.S163L		NM_198498.1	NP_940900.1	Q8IXP5	CK053_HUMAN	chromosome 11 open reading frame 53	163										endometrium(1)|large_intestine(2)|lung(3)|skin(2)	8		all_cancers(61;2.05e-09)|Melanoma(852;4.04e-05)|all_epithelial(67;6.15e-05)|all_hematologic(158;0.000826)|Acute lymphoblastic leukemia(157;0.000966)|all_neural(223;0.0332)|Medulloblastoma(222;0.0425)|Breast(348;0.147)		Epithelial(105;1.7e-06)|BRCA - Breast invasive adenocarcinoma(274;3.16e-06)|all cancers(92;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0507)		CAGTCATACTCGCTGCATGCT	0.627000													22	47					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8418477	8418477	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:8418477G>A	ENST00000337907.3	-	21	4752	c.4118C>T	c.(4117-4119)cCc>cTc	p.P1373L	RERE_ENST00000476556.1_Missense_Mutation_p.P819L|RERE_ENST00000400907.2_Intron|RERE_ENST00000377464.1_Missense_Mutation_p.P1105L|RERE_ENST00000400908.2_Missense_Mutation_p.P1373L	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	1373					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		CCTCTCCAAGGGGTTCAGGCC	0.692000													4	11					0	0	1	0	0
CXorf36	79742	broad.mit.edu	37	X	45013411	45013411	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:45013411G>A	ENST00000398000.2	-	4	779	c.705C>T	c.(703-705)ccC>ccT	p.P235P	CXorf36_ENST00000477281.1_Intron	NM_176819.3	NP_789789.2	Q9H7Y0	CX036_HUMAN	chromosome X open reading frame 36	235						extracellular region				endometrium(1)|large_intestine(2)|lung(4)	7						CCAGGTACTTGGGCAGCGGCC	0.557000													9	11					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44934627	44934627	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:44934627T>G	ENST00000291187.4	-	6	633	c.311A>C	c.(310-312)gAa>gCa	p.E104A	ZNF229_ENST00000588931.1_Missense_Mutation_p.E110A|CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000591289.1_Intron	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	110	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				TGCCACCTCTTCCCAGATTTT	0.443000													17	23					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105405414	105405414	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:105405414G>A	ENST00000333244.5	-	7	16493	c.16374C>T	c.(16372-16374)ccC>ccT	p.P5458P	AHNAK2_ENST00000557457.1_Silent_p.P456P	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	5458						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			TTGAAATTGGGGGAGCTTCCA	0.537000													6	4					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75037700	75037700	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:75037700C>T	ENST00000326665.5	-	14	3912	c.3694G>A	c.(3694-3696)Ggg>Agg	p.G1232R	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1232	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						GGGATCAGCCCCTCAGGGGCC	0.632000													36	40					0	0	1	0	0
FGR	2268	broad.mit.edu	37	1	27949654	27949654	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:27949654C>T	ENST00000374005.3	-	4	516	c.226_splice	c.e4-1	p.G76_splice	FGR_ENST00000545953.1_Splice_Site_p.G76_splice|FGR_ENST00000374004.1_Splice_Site_p.G76_splice|FGR_ENST00000399173.1_Splice_Site_p.G76_splice	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	76					platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity	p.G76G(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TCACCCCAATCCCTGCAGAGT	0.572000													3	13					0	0	1	0	0
RFTN1	23180	broad.mit.edu	37	3	16368346	16368346	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:16368346T>C	ENST00000334133.4	-	8	1456	c.1184A>G	c.(1183-1185)aAc>aGc	p.N395S	RFTN1_ENST00000483671.1_5'UTR|OXNAD1_ENST00000435829.2_Intron|RFTN1_ENST00000432519.1_Missense_Mutation_p.N359S|OXNAD1_ENST00000606098.1_Intron|OXNAD1_ENST00000544043.1_Intron|OXNAD1_ENST00000605932.1_Intron	NM_015150.1	NP_055965.1	Q14699	RFTN1_HUMAN	raftlin, lipid raft linker 1	395						plasma membrane				central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(3)|large_intestine(8)|lung(8)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	38						CGCCAGCGAGTTCAGCAGGGG	0.547000													17	15					0	0	1	0	0
MAP3K15	389840	broad.mit.edu	37	X	19428074	19428074	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:19428074C>T	ENST00000338883.4	-	12	1715	c.1716G>A	c.(1714-1716)tgG>tgA	p.W572*	MAP3K15_ENST00000359173.3_Nonsense_Mutation_p.W7*|MAP3K15_ENST00000518578.1_5'UTR|MAP3K15_ENST00000469203.2_Nonsense_Mutation_p.W404*	NM_001001671.3	NP_001001671.3	Q6ZN16	M3K15_HUMAN	mitogen-activated protein kinase kinase kinase 15	572							ATP binding|MAP kinase kinase kinase activity|metal ion binding			NS(2)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(13)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	42	Hepatocellular(33;0.183)					CTGTAAAATTCCATTCGTGCA	0.299000													5	20					0	0	1	0	0
ZNF74	7625	broad.mit.edu	37	22	20760067	20760067	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:20760067C>T	ENST00000400451.2	+	5	1258	c.744C>T	c.(742-744)ttC>ttT	p.F248F	ZNF74_ENST00000403682.3_3'UTR|ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000356671.5_Silent_p.F248F|ZNF74_ENST00000405993.1_Silent_p.F216F	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	248					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			AGGGCGAGTTCGTGTGCGGCG	0.687000													6	6					0	0	1	0	0
PRSS23	11098	broad.mit.edu	37	11	86518725	86518725	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:86518725C>T	ENST00000280258.5	+	2	465	c.40C>T	c.(40-42)Ctg>Ttg	p.L14L	PRSS23_ENST00000441050.1_Silent_p.L14L|PRSS23_ENST00000533902.2_Intron	NM_007173.4	NP_009104.1	O95084	PRS23_HUMAN	protease, serine, 23	14					proteolysis	extracellular region|nucleus	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(9)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	18		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				TCTCTTCTTTCTGCTCTGTGC	0.567000													36	60					0	0	1	0	0
RBCK1	10616	broad.mit.edu	37	20	409599	409599	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:409599T>C	ENST00000356286.5	+	11	2018	c.1313T>C	c.(1312-1314)aTg>aCg	p.M438T	RBCK1_ENST00000382181.2_Missense_Mutation_p.M268T|RBCK1_ENST00000353660.3_Missense_Mutation_p.M396T	NM_031229.2	NP_112506.2	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing 1	438					interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|lung(4)	5		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				CTCCAGGTGATGCTGCAGCAG	0.687000													6	10					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123847857	123847857	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:123847857A>T	ENST00000531945.1	-	1	631	c.542T>A	c.(541-543)cTc>cAc	p.L181H		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	181					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CCCACAGTAGAGCAGGCGGAA	0.547000													16	30					0	0	1	0	0
FANCD2	2177	broad.mit.edu	37	3	10101995	10101995	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:10101995G>A	ENST00000287647.3	+	19	1767	c.1674G>A	c.(1672-1674)gtG>gtA	p.V558V	FANCD2_ENST00000383806.1_Silent_p.V558V|FANCD2_ENST00000383807.1_Silent_p.V558V|FANCD2_ENST00000419585.1_Silent_p.V558V	NM_033084.3	NP_149075.2	Q9BXW9	FACD2_HUMAN	Fanconi anemia, complementation group D2	558					DNA repair|response to gamma radiation	nucleoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	51				OV - Ovarian serous cystadenocarcinoma(96;0.148)		TGCACTTGGTGATAAGAAAGC	0.458000			"""D, Mis, N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				10	11					0	0	1	0	0
RTTN	25914	broad.mit.edu	37	18	67836252	67836252	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:67836252A>T	ENST00000255674.6	-	12	1814	c.1528T>A	c.(1528-1530)Ttg>Atg	p.L510M	RTTN_ENST00000437017.1_Missense_Mutation_p.L510M|RTTN_ENST00000454359.1_Missense_Mutation_p.L510M	NM_173630.3	NP_775901.3	Q86VV8	RTTN_HUMAN	rotatin	510							binding			NS(1)|breast(3)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(35)|ovary(4)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Esophageal squamous(42;0.129)				GGCATGTCCAAAGAAAGGAGA	0.313000													10	20					0	0	1	0	0
CASC3	22794	broad.mit.edu	37	17	38324456	38324456	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:38324456G>A	ENST00000264645.7	+	11	1977	c.1750_splice	c.e11-1	p.G584_splice		NM_007359.4	NP_031385.2	O15234	CASC3_HUMAN	cancer susceptibility candidate 3	584	Necessary for localization in cytoplasmic stress granules.				mRNA processing|mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translation|response to stress|RNA splicing	exon-exon junction complex|nuclear speck|perinuclear region of cytoplasm	identical protein binding|RNA binding|ubiquitin protein ligase binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(2)	16						CCTTATCCAGGTTTACATCCC	0.498000											OREG0024392	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	73					0	0	1	0	0
OR2B6	26212	broad.mit.edu	37	6	27925746	27925746	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:27925746C>T	ENST00000244623.1	+	1	728	c.728C>T	c.(727-729)tCc>tTc	p.S243F		NM_012367.1	NP_036499.1	P58173	OR2B6_HUMAN	olfactory receptor, family 2, subfamily B, member 6	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(12)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ACATGTGGTTCCCATCTAATT	0.458000													32	104					0	0	1	0	0
OR56A3	390083	broad.mit.edu	37	11	5969351	5969351	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:5969351C>T	ENST00000329564.6	+	1	782	c.775C>T	c.(775-777)Ctt>Ttt	p.L259F		NM_001003443.2	NP_001003443.2	Q8NH54	O56A3_HUMAN	olfactory receptor, family 56, subfamily A, member 3	259					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(27)|stomach(1)|upper_aerodigestive_tract(1)	41		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;9.41e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGCACCATCCTTCTGGTTTT	0.522000													56	81					0	0	1	0	0
COQ4	51117	broad.mit.edu	37	9	131085313	131085313	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:131085313G>A	ENST00000300452.3	+	2	412	c.89G>A	c.(88-90)aGg>aAg	p.R30K	COQ4_ENST00000372875.3_Missense_Mutation_p.R30K	NM_016035.3	NP_057119.2	Q9Y3A0	COQ4_HUMAN	coenzyme Q4	30					ubiquinone biosynthetic process	mitochondrial inner membrane				endometrium(4)|large_intestine(1)|lung(4)	9						CTCCGGGCTAGGAGCGACGGC	0.706000													26	12					0	0	1	0	0
VAT1L	57687	broad.mit.edu	37	16	77859208	77859208	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:77859208G>A	ENST00000302536.2	+	3	582	c.429G>A	c.(427-429)gtG>gtA	p.V143V		NM_020927.1	NP_065978.1	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport 1-like	143							oxidoreductase activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(10)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24						GCACACCAGTGGAGTTTGTCT	0.512000													12	27					0	0	1	0	0
CACNG6	59285	broad.mit.edu	37	19	54515331	54515331	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:54515331G>A	ENST00000252729.2	+	4	1261	c.671G>A	c.(670-672)gGc>gAc	p.G224D	CACNG6_ENST00000346968.2_Missense_Mutation_p.G178D|CACNG6_ENST00000352529.1_Missense_Mutation_p.G153D	NM_145814.1	NP_665813.1	Q9BXT2	CCG6_HUMAN	calcium channel, voltage-dependent, gamma subunit 6	224						voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.168)		CTGGGCTGCGGCGTGGGGGCC	0.706000													29	55					0	0	1	0	0
SYNPR	132204	broad.mit.edu	37	3	63466543	63466543	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:63466543C>T	ENST00000478300.1	+	3	531	c.120C>T	c.(118-120)ggC>ggT	p.G40G	SYNPR_ENST00000460711.1_Silent_p.G31G|SYNPR-AS1_ENST00000488201.1_RNA|SYNPR_ENST00000479198.1_Silent_p.G20G|SYNPR_ENST00000295894.5_Silent_p.G20G|SYNPR_ENST00000465156.1_Silent_p.G20G|SYNPR_ENST00000478744.1_3'UTR	NM_001130003.1	NP_001123475.1	Q8TBG9	SYNPR_HUMAN	synaptoporin	20	MARVEL.					cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	transporter activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	8				BRCA - Breast invasive adenocarcinoma(55;0.000918)|KIRC - Kidney renal clear cell carcinoma(15;0.0658)|Kidney(15;0.0904)		CATGCGGTGGCTATTCTGGAG	0.443000													33	56					0	0	1	0	0
STEAP2	261729	broad.mit.edu	37	7	89861917	89861917	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:89861917G>A	ENST00000287908.3	+	5	1845	c.1452G>A	c.(1450-1452)ccG>ccA	p.P484P	STEAP2_ENST00000394626.1_Intron|STEAP2_ENST00000394629.2_Intron|STEAP2_ENST00000402625.2_Intron|STEAP2_ENST00000394621.2_Silent_p.P484P|STEAP2_ENST00000394632.1_Intron|STEAP2_ENST00000394622.2_Silent_p.P484P	NM_001244944.1|NM_152999.3	NP_001231873.1|NP_694544.2	Q8NFT2	STEA2_HUMAN	STEAP family member 2, metalloreductase	484					electron transport chain|endocytosis|Golgi to plasma membrane transport|ion transport|iron ion homeostasis|regulated secretory pathway|response to hormone stimulus	cytosol|early endosome|endosome membrane|integral to Golgi membrane|plasma membrane|trans-Golgi network transport vesicle|vesicular fraction	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|oxidoreductase activity|transporter activity	p.P484P(1)		endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)	15	all_hematologic(106;0.112)					ATGTCTCCCCGGAGAGGGTCA	0.403000													7	16					0	0	1	0	0
FOXC2	2303	broad.mit.edu	37	16	86602438	86602438	+	Silent	SNP	G	G	A	rs148657129		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:86602438G>A	ENST00000320354.4	+	1	1582	c.1497G>A	c.(1495-1497)acG>acA	p.T499T		NM_005251.2	NP_005242.1	Q99958	FOXC2_HUMAN	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	499					anti-apoptosis|artery morphogenesis|blood vessel remodeling|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|embryonic viscerocranium morphogenesis|insulin receptor signaling pathway|lymphangiogenesis|metanephros development|negative regulation of transcription from RNA polymerase II promoter|neural crest cell fate commitment|Notch signaling pathway|ossification|paraxial mesodermal cell fate commitment|patterning of blood vessels|positive regulation of cell adhesion mediated by integrin|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vascular wound healing|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	15						ACGACTGCACGAAATACTGAC	0.647000									Late-onset Hereditary Lymphedema				12	21					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121348903	121348903	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:121348903G>A	ENST00000260197.7	+	3	608	c.479G>A	c.(478-480)aGt>aAt	p.S160N	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	160					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		GGAAATAGGAGTGAAGCTGTT	0.473000													9	12					0	0	1	0	0
PTPRS	5802	broad.mit.edu	37	19	5243950	5243950	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:5243950G>A	ENST00000372412.4	-	11	1768	c.1535C>T	c.(1534-1536)cCc>cTc	p.P512L	PTPRS_ENST00000592099.1_Missense_Mutation_p.P498L|PTPRS_ENST00000587303.1_Missense_Mutation_p.P511L|PTPRS_ENST00000357368.4_Missense_Mutation_p.P511L|PTPRS_ENST00000353284.2_Missense_Mutation_p.P498L|PTPRS_ENST00000348075.2_Missense_Mutation_p.P498L|PTPRS_ENST00000262963.6_Missense_Mutation_p.P507L|PTPRS_ENST00000588552.1_5'UTR|PTPRS_ENST00000588012.1_Missense_Mutation_p.P498L			Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type, S	511	Fibronectin type-III 2.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.P511L(1)		NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|liver(1)|lung(9)|ovary(4)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)	61				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GTCCGAGAGGGGCCCGTCGCC	0.692000													5	9					0	0	1	0	0
UNC45B	146862	broad.mit.edu	37	17	33504104	33504104	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:33504104G>A	ENST00000268876.5	+	16	2197	c.2100G>A	c.(2098-2100)aaG>aaA	p.K700K	UNC45B_ENST00000378449.1_Silent_p.K619K|UNC45B_ENST00000394570.2_Silent_p.K698K|UNC45B_ENST00000433649.1_Silent_p.K698K|UNC45B_ENST00000591048.1_Silent_p.K619K	NM_173167.2	NP_775259.1	Q8IWX7	UN45B_HUMAN	unc-45 homolog B (C. elegans)	700					cell differentiation|muscle organ development	cytosol	binding			breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(10)|lung(24)|ovary(3)|prostate(2)|skin(1)|stomach(1)|urinary_tract(3)	59		Ovarian(249;0.17)				CTCTAGCAAAGATCGCTGCTG	0.567000													47	44					0	0	1	0	0
CPXM1	56265	broad.mit.edu	37	20	2779094	2779094	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:2779094G>A	ENST00000380605.2	-	3	494	c.430C>T	c.(430-432)Cga>Tga	p.R144*		NM_001184699.1|NM_019609.4	NP_001171628.1|NP_062555.1	Q96SM3	CPXM1_HUMAN	carboxypeptidase X (M14 family), member 1	144	F5/8 type C.				cell adhesion|proteolysis		metallocarboxypeptidase activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(8)|lung(17)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						AGCCGTCCTCGGTGTGGTCCA	0.612000													19	28					0	0	1	0	0
APAF1	317	broad.mit.edu	37	12	99126212	99126212	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:99126212C>T	ENST00000333991.1	+	8	1547	c.970C>T	c.(970-972)Cac>Tac	p.H324Y	APAF1_ENST00000550527.1_Silent_p.V1194V|APAF1_ENST00000551964.1_Silent_p.V1205V|APAF1_ENST00000339433.3_Silent_p.V1120V|APAF1_ENST00000357310.1_Silent_p.V1162V|APAF1_ENST00000549007.1_Silent_p.V1120V|APAF1_ENST00000359972.2_Silent_p.V1151V|APAF1_ENST00000547045.1_Silent_p.V1162V|APAF1_ENST00000552268.1_Missense_Mutation_p.H324Y	NM_181869.1	NP_863659.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	327	NB-ARC.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	GGAACGTTGTCACTGGGGAAT	0.388000													8	15					0	0	1	0	0
SYVN1	84447	broad.mit.edu	37	11	64897788	64897788	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:64897788G>A	ENST00000526060.1	-	12	1361	c.1169C>T	c.(1168-1170)cCc>cTc	p.P390L	SYVN1_ENST00000377190.3_Missense_Mutation_p.P390L|SYVN1_ENST00000307289.6_Missense_Mutation_p.P339L|SYVN1_ENST00000294256.8_Missense_Mutation_p.P390L			Q86TM6	SYVN1_HUMAN	synovial apoptosis inhibitor 1, synoviolin	390	Pro-rich.				ER-associated protein catabolic process|response to stress	endoplasmic reticulum membrane|integral to membrane|nucleus	acid-amino acid ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	22						AGGTGGAAAGGGGCCCATGGG	0.642000													4	5					0	0	1	0	0
FBXL17	64839	broad.mit.edu	37	5	107216803	107216803	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:107216803C>T	ENST00000542267.1	-	8	2306	c.1900G>A	c.(1900-1902)Gga>Aga	p.G634R	FBXL17_ENST00000496714.1_Missense_Mutation_p.G236R|FBXL17_ENST00000359660.5_Missense_Mutation_p.G236R	NM_001163315.2	NP_001156787.2	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	634										endometrium(1)|large_intestine(4)|lung(1)	6		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		AGGGTGGCTCCTTGGTCTGTG	0.453000													38	49					0	0	1	0	0
GPHN	10243	broad.mit.edu	37	14	67589053	67589053	+	Silent	SNP	A	A	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:67589053A>G	ENST00000478722.1	+	17	2828	c.1707A>G	c.(1705-1707)gaA>gaG	p.E569E	GPHN_ENST00000544752.2_3'UTR|GPHN_ENST00000543237.1_Silent_p.E582E|GPHN_ENST00000305960.9_Silent_p.E505E|GPHN_ENST00000315266.5_Silent_p.E536E	NM_020806.4	NP_065857.1	Q9NQX3	GEPH_HUMAN	gephyrin	536	MPT adenylyltransferase.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cell junction|cytoplasm|cytoskeleton|postsynaptic membrane	ATP binding|metal ion binding|nucleotidyltransferase activity			large_intestine(8)|liver(1)|ovary(2)|stomach(1)	12		all_cancers(7;0.0476)|all_hematologic(31;0.0116)		Epithelial(1;1.73e-08)|all cancers(60;3.15e-07)|OV - Ovarian serous cystadenocarcinoma(108;0.000275)|BRCA - Breast invasive adenocarcinoma(234;0.00323)|Colorectal(3;0.0938)|KIRC - Kidney renal clear cell carcinoma(182;0.184)		CAATTCAGGAACATGGTTACC	0.388000			T	MLL	AL								11	22					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155507510	155507510	+	Silent	SNP	G	G	T	rs6051		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:155507510G>T	ENST00000302053.3	-	5	1149	c.1071C>A	c.(1069-1071)acC>acA	p.T357T	FGA_ENST00000403106.3_Silent_p.T357T	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	357					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TCCAGGTTCCGGTACTACCAG	0.552000													34	52					8.4185e-14	8.55012e-14	1	1	0
IGLV2-33	28811	broad.mit.edu	37	22	22931012	22931012	+	RNA	SNP	T	T	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:22931012T>A	ENST00000390302.2	+	0	265																											GACTCCTGATTTACAATGTCA	0.527000													72	132					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167653130	167653130	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:167653130C>T	ENST00000519204.1	+	23	4901	c.4783C>T	c.(4783-4785)Ccc>Tcc	p.P1595S	TENM2_ENST00000403607.2_Missense_Mutation_p.P1540S|TENM2_ENST00000518659.1_Missense_Mutation_p.P1716S|TENM2_ENST00000545108.1_Missense_Mutation_p.P1715S|TENM2_ENST00000520394.1_Missense_Mutation_p.P1477S					teneurin transmembrane protein 2																		CGTGACGCGCCCCACGGGGGT	0.522000													5	8					0	0	1	0	0
TRPC5	7224	broad.mit.edu	37	X	111019941	111019941	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:111019941G>A	ENST00000262839.2	-	11	3440	c.2522C>T	c.(2521-2523)tCt>tTt	p.S841F		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	841					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TTTCTTGAGAGAAGGACCCAT	0.468000													31	50					0	0	1	0	0
MRPL2	51069	broad.mit.edu	37	6	43025923	43025923	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:43025923G>A	ENST00000388752.3	-	2	569	c.145C>T	c.(145-147)Ccc>Tcc	p.P49S	MRPL2_ENST00000230413.5_Missense_Mutation_p.P49S|MRPL2_ENST00000468957.1_Missense_Mutation_p.P49S|MRPL2_ENST00000487429.1_Missense_Mutation_p.P84L|MRPL2_ENST00000489623.1_Missense_Mutation_p.P49S	NM_015950.3	NP_057034.2	Q5T653	RM02_HUMAN	mitochondrial ribosomal protein L2	49					translation	mitochondrion|ribosome	structural constituent of ribosome			breast(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(2)	9		Ovarian(999;0.0014)	Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|all cancers(41;0.00708)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)	BRCA - Breast invasive adenocarcinoma(397;0.0026)		GGGCGGCAGGGGAGCAACATC	0.468000													27	66					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94088083	94088083	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:94088083C>T	ENST00000553484.1	+	31	4724	c.4570C>T	c.(4570-4572)Ctt>Ttt	p.L1524F	UNC79_ENST00000555664.1_Missense_Mutation_p.L1502F|UNC79_ENST00000256339.4_Missense_Mutation_p.L1325F|UNC79_ENST00000393151.2_Missense_Mutation_p.L1502F			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1502						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						ACAAAAATCTCTTGATATAGG	0.433000													16	42					0	0	1	0	0
PHLDB3	653583	broad.mit.edu	37	19	43979574	43979574	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:43979574G>A	ENST00000292140.5	-	16	2271	c.1911C>T	c.(1909-1911)aaC>aaT	p.N637N		NM_198850.3	NP_942147.3	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B, member 3	637										breast(1)|central_nervous_system(1)|lung(5)	7		Prostate(69;0.0153)				AGGGGGCGTGGTTTTCGTCAG	0.672000													16	15					0	0	1	0	0
RPN2	6185	broad.mit.edu	37	20	35865053	35865053	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:35865053C>T	ENST00000237530.6	+	16	2135	c.1824C>T	c.(1822-1824)atC>atT	p.I608I	RPN2_ENST00000470352.1_3'UTR|RPN2_ENST00000373622.5_Silent_p.I576I	NM_002951.3	NP_002942.2	P04844	RPN2_HUMAN	ribophorin II	608					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|nucleus|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|pancreas(1)|skin(2)|stomach(1)	24		Myeloproliferative disorder(115;0.00878)				ACCTGGCCATCCTGGGCAGTG	0.522000													20	19					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80388641	80388641	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:80388641C>T	ENST00000265080.4	+	10	1479	c.1412C>T	c.(1411-1413)tCc>tTc	p.S471F		NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	471	PH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity	p.S471F(1)		biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		CAAGTACCTTCCGTTGAGAGG	0.373000													18	37					0	0	1	0	0
ZNF280C	55609	broad.mit.edu	37	X	129373651	129373651	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:129373651G>A	ENST00000370978.4	-	6	551	c.398C>T	c.(397-399)tCa>tTa	p.S133L		NM_017666.4	NP_060136.1	Q8ND82	Z280C_HUMAN	zinc finger protein 280C	133	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(4)|large_intestine(9)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26						TCCAACTTGTGAATTCTTTGT	0.294000													8	15					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179613203	179613203	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:179613203C>T	ENST00000360870.5	-	46	14146	c.13924G>A	c.(13924-13926)Gaa>Aaa	p.E4642K	TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	756	Ig-like 26.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TAATGTATTTCCTGCTGTTCC	0.368000													35	19					0	0	1	0	0
TRIM31	11074	broad.mit.edu	37	6	30078327	30078327	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:30078327C>T	ENST00000376734.3	-	4	767	c.642G>A	c.(640-642)ggG>ggA	p.G214G	TRIM31-AS1_ENST00000440874.1_RNA|TRIM31_ENST00000540829.1_Silent_p.G214G|TRIM31_ENST00000485864.1_5'UTR	NM_007028.3	NP_008959.3	Q9BZY9	TRI31_HUMAN	tripartite motif containing 31	214						mitochondrion	ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(2)	15						CATAGTGTTTCCCCGCTTCCG	0.512000													37	98					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85701308	85701308	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:85701308T>A	ENST00000322366.6	-	26	4725	c.4318A>T	c.(4318-4320)Agt>Tgt	p.S1440C	WDFY3_ENST00000295888.4_Missense_Mutation_p.S1440C			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	1440						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		AGTGGGTTACTCTTGACCACA	0.502000													39	72					0	0	1	0	0
ZNF157	7712	broad.mit.edu	37	X	47272937	47272937	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:47272937C>T	ENST00000377073.3	+	4	1551	c.1465C>T	c.(1465-1467)Cag>Tag	p.Q489*		NM_003446.3	NP_003437.2	P51786	ZN157_HUMAN	zinc finger protein 157	489					negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(5)|upper_aerodigestive_tract(1)	11						CACAGAACATCAGAGAACTCA	0.488000													21	17					0	0	1	0	0
ALDH3B2	222	broad.mit.edu	37	11	67431903	67431903	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:67431903C>T	ENST00000349015.3	-	8	1275	c.837G>A	c.(835-837)aaG>aaA	p.K279K	ALDH3B2_ENST00000530069.1_Silent_p.K279K	NM_000695.3	NP_000686.2	P48448	AL3B2_HUMAN	aldehyde dehydrogenase 3 family, member B2	279					alcohol metabolic process|cellular aldehyde metabolic process|lipid metabolic process		3-chloroallyl aldehyde dehydrogenase activity|aldehyde dehydrogenase			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	18					NADH(DB00157)	GGGCCAGGGGCTTCTCCTGCC	0.642000													31	70					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42163550	42163550	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:42163550C>T	ENST00000444063.1	+	13	1655	c.1523C>T	c.(1522-1524)tCc>tTc	p.S508F	L3MBTL1_ENST00000373134.1_Missense_Mutation_p.S508F|L3MBTL1_ENST00000373135.3_Missense_Mutation_p.S508F|L3MBTL1_ENST00000418998.1_Missense_Mutation_p.S576F|L3MBTL1_ENST00000427442.2_Missense_Mutation_p.S576F			Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	508					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						GGCTGGTGCTCCAAGACAGGA	0.557000													7	14					0	0	1	0	0
IL12A-AS1	101928376	broad.mit.edu	37	3	159820620	159820620	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:159820620C>T	ENST00000497452.1	-	0	517																											CATACTTTTTCATTCTTAACT	0.299000													7	8					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35743124	35743124	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:35743124G>A	ENST00000400445.3	+	25	4768	c.4233_splice	c.e25-1	p.G1412_splice	NBEA_ENST00000379939.2_Intron|NBEA_ENST00000310336.4_Intron|NBEA_ENST00000540320.1_Intron	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	1412						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GCATGTCCAGGGTTCTAAGGT	0.249000													9	38					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2824233	2824233	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:2824233C>T	ENST00000520002.1	-	59	9517	c.8962G>A	c.(8962-8964)Gga>Aga	p.G2988R	CSMD1_ENST00000542608.1_Intron|CSMD1_ENST00000537824.1_Missense_Mutation_p.G2987R|CSMD1_ENST00000602723.1_Intron|CSMD1_ENST00000400186.3_Intron|CSMD1_ENST00000602557.1_Missense_Mutation_p.G2988R			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2988	Sushi 23.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ACAATCATTCCGTTGGTGGGT	0.527000													5	10					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110862343	110862343	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:110862343C>T	ENST00000375820.4	-	10	720	c.599G>A	c.(598-600)gGa>gAa	p.G200E	COL4A1_ENST00000543140.1_Missense_Mutation_p.G200E	NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	200	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			TCCGGTAAATCCTGGAGGCCC	0.453000													38	16					0	0	1	0	0
SLC6A14	11254	broad.mit.edu	37	X	115584239	115584239	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:115584239C>T	ENST00000371900.4	+	9	1305	c.1217C>T	c.(1216-1218)cCa>cTa	p.P406L		NM_007231.3	NP_009162.1	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid transporter), member 14	406					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	CCAGGTGGTCCATTTTGGTCC	0.363000													17	33					0	0	1	0	0
PRB2	653247	broad.mit.edu	37	12	11546884	11546884	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:11546884C>T	ENST00000389362.4	-	3	163	c.128G>A	c.(127-129)gGa>gAa	p.G43E	PRB1_ENST00000546254.1_Intron	NM_006248.3	NP_006239.3			proline-rich protein BstNI subfamily 2									p.?(1)|p.A39_G59delAPPQGGNKPQGPPSPPGKPQG(1)		NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(5)|skin(4)|stomach(2)|urinary_tract(1)	37		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTTGTTGCCTCCTTGTGGGGG	0.522000													62	114					0	0	1	0	0
SLC7A3	84889	broad.mit.edu	37	X	70146884	70146884	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:70146884G>A	ENST00000374299.3	-	9	1438	c.1294C>T	c.(1294-1296)Cct>Tct	p.P432S	SLC7A3_ENST00000298085.4_Missense_Mutation_p.P432S			Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	432					cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|urinary_tract(1)	31	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	TCCTGATCAGGTTGATACCTG	0.438000													14	18					0	0	1	0	0
TMCC2	9911	broad.mit.edu	37	1	205238605	205238605	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:205238605C>T	ENST00000358024.3	+	3	1664	c.1275C>T	c.(1273-1275)ccC>ccT	p.P425P	TMCC2_ENST00000545499.1_Silent_p.P347P|TMCC2_ENST00000329800.7_Silent_p.P185P|TMCC2_ENST00000330675.7_Silent_p.P200P|TMCC2_ENST00000495538.1_3'UTR	NM_014858.3	NP_055673.2	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	425						integral to membrane	protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(2)|lung(3)|pancreas(1)|skin(1)|urinary_tract(1)	20	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			TGTCCAAGCCCCGGGAGTTTG	0.672000													19	46					0	0	1	0	0
C1orf162	128346	broad.mit.edu	37	1	112019446	112019446	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:112019446G>T	ENST00000343534.5	+	3	314	c.64G>T	c.(64-66)Gcc>Tcc	p.A22S	C1orf162_ENST00000369718.3_Missense_Mutation_p.A22S|C1orf162_ENST00000464591.1_3'UTR	NM_174896.2	NP_777556.1	Q8NEQ5	CA162_HUMAN	chromosome 1 open reading frame 162	22						integral to membrane				NS(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	5		all_cancers(81;0.00116)|all_epithelial(167;0.000761)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0236)|Colorectal(144;0.0286)|all cancers(265;0.0572)|Epithelial(280;0.0862)|COAD - Colon adenocarcinoma(174;0.112)|LUSC - Lung squamous cell carcinoma(189;0.134)		CTCCACAGCAGCCCCAACAAC	0.448000													43	67					2.40228e-13	2.43544e-13	1	1	0
MSX1	4487	broad.mit.edu	37	4	4864788	4864788	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:4864788C>T	ENST00000382723.4	+	2	1064	c.830C>T	c.(829-831)cCc>cTc	p.P277L		NM_002448.3	NP_002439.2	P28360	MSX1_HUMAN	msh homeobox 1	271					apoptotic nuclear change|face morphogenesis|negative regulation of cell growth|odontogenesis of dentine-containing tooth|positive regulation of apoptosis|protein localization to nucleus|protein stabilization	nucleus	p53 binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|lung(5)|ovary(1)|prostate(1)|urinary_tract(1)	11				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GCCTCTGGCCCCTTCCAGCGC	0.711000													5	10					0	0	1	0	0
OSMR	9180	broad.mit.edu	37	5	38881697	38881697	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:38881697G>A	ENST00000274276.3	+	4	651	c.249G>A	c.(247-249)ggG>ggA	p.G83G	OSMR_ENST00000502536.1_Silent_p.G83G	NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	83					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					GCTTTTAGGGGAATTACAGCA	0.423000													13	23					0	0	1	0	0
KDM5C	8242	broad.mit.edu	37	X	53222467	53222467	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:53222467C>T	ENST00000375401.3	-	26	4897	c.4365G>A	c.(4363-4365)ctG>ctA	p.L1455L	KDM5C_ENST00000452825.3_Intron|KDM5C_ENST00000404049.3_Silent_p.L1454L|KDM5C_ENST00000375379.3_Silent_p.L1452L|KDM5C_ENST00000375383.3_Silent_p.L1411L	NM_004187.3	NP_004178.2	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	1455					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						GCCGCCTCTCCAGGGCCCGGC	0.677000			"""N, F, S"""		clear cell renal carcinoma								12	20					0	0	1	0	0
KLHL35	283212	broad.mit.edu	37	11	75134884	75134884	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:75134884C>T	ENST00000539798.1	-	5	1414	c.1415G>A	c.(1414-1416)cGg>cAg	p.R472Q	KLHL35_ENST00000376292.4_Missense_Mutation_p.R252Q	NM_001039548.2	NP_001034637.2	Q6PF15	KLH35_HUMAN	kelch-like family member 35	252										lung(2)|stomach(1)	3						TGCTGGTGACCGCAGGCTCCA	0.592000													23	30					0	0	1	0	0
ENDOU	8909	broad.mit.edu	37	12	48104522	48104522	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:48104522C>T	ENST00000542202.1	-	6	902	c.451G>A	c.(451-453)Gac>Aac	p.D151N	RP1-197B17.3_ENST00000547799.1_lincRNA|ENDOU_ENST00000545824.2_3'UTR|ENDOU_ENST00000422538.3_3'UTR|ENDOU_ENST00000229003.3_3'UTR			P21128	ENDOU_HUMAN	endonuclease, polyU-specific	0					female pregnancy|immune response|proteolysis	cytoplasm|extracellular space|plasma membrane	endoribonuclease activity|growth factor activity|manganese ion binding|polysaccharide binding|RNA binding|scavenger receptor activity|serine-type peptidase activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(4)|lung(2)|ovary(3)|pancreas(1)|stomach(1)	14						TCTCTCTAGTCCAGAGAAGAT	0.473000													11	18					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108182076	108182076	+	Silent	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:108182076G>T	ENST00000273353.3	-	17	1862	c.1806C>A	c.(1804-1806)atC>atA	p.I602I		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	602	Myosin head-like.					myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						GCCAACCACTGATATTATAAG	0.373000													10	78					0.00829132	0.00830115	1	1	0
WDR33	55339	broad.mit.edu	37	2	128522370	128522370	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:128522370G>A	ENST00000409658.3	-	6	840	c.658C>T	c.(658-660)Cct>Tct	p.P220S	WDR33_ENST00000322313.4_Intron|WDR33_ENST00000393006.1_Intron	NM_001006622.2	NP_001006623.1	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	0					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		ATGACAATAGGGACTACAGAA	0.413000													30	11					0	0	1	0	0
ALG13	79868	broad.mit.edu	37	X	110970246	110970246	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:110970246C>T	ENST00000394780.3	+	16	1951	c.1939C>T	c.(1939-1941)Cca>Tca	p.P647S	ALG13_ENST00000251943.4_Missense_Mutation_p.P543S|ALG13_ENST00000470971.1_3'UTR	NM_001099922.2|NM_001257231.1	NP_001093392.1|NP_001244160.1	Q9NP73	ALG13_HUMAN	ALG13, UDP-N-acetylglucosaminyltransferase subunit	647					dolichol-linked oligosaccharide biosynthetic process|lipid glycosylation|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane	carbohydrate binding|N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			endometrium(2)|lung(10)|skin(1)	13						TCCTCAGCATCCATCTCCGAG	0.453000													29	47					0	0	1	0	0
RRAGB	10325	broad.mit.edu	37	X	55779873	55779873	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:55779873G>A	ENST00000374941.4	+	7	1250	c.661G>A	c.(661-663)Gaa>Aaa	p.E221K	RRAGB_ENST00000262850.7_Missense_Mutation_p.E249K	NM_006064.4	NP_006055.3	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B	249					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding			breast(1)|endometrium(3)|large_intestine(5)|lung(3)|pancreas(1)|prostate(1)	14						TCAGCAGCTGGAAATGAACCT	0.393000													10	16					0	0	1	0	0
ZNF510	22869	broad.mit.edu	37	9	99521509	99521509	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:99521509G>A	ENST00000375231.1	-	6	2253	c.1603C>T	c.(1603-1605)Cag>Tag	p.Q535*	ZNF510_ENST00000223428.4_Nonsense_Mutation_p.Q535*			Q9Y2H8	ZN510_HUMAN	zinc finger protein 510	535					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(8)|stomach(1)|urinary_tract(1)	21		Acute lymphoblastic leukemia(62;0.0527)				TGAGTTCTCTGATGTATTCTG	0.413000													44	18					0	0	1	0	0
CD209	30835	broad.mit.edu	37	19	7809008	7809008	+	Missense_Mutation	SNP	G	G	A	rs148485547		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:7809008G>A	ENST00000315599.7	-	6	1020	c.998C>T	c.(997-999)tCa>tTa	p.S333L	CD209_ENST00000602261.1_Missense_Mutation_p.S241L|CD209_ENST00000601256.1_Intron|CD209_ENST00000315591.8_Missense_Mutation_p.S309L|CD209_ENST00000601951.1_Missense_Mutation_p.S309L|CD209_ENST00000354397.6_Missense_Mutation_p.S327L|CD209_ENST00000301357.8_Missense_Mutation_p.S197L|CD209_ENST00000593821.1_Missense_Mutation_p.S197L|CD209_ENST00000593660.1_Missense_Mutation_p.S263L|CD209_ENST00000204801.8_Missense_Mutation_p.S289L|CD209_ENST00000394161.5_Missense_Mutation_p.S97L|CD209_ENST00000394173.4_Missense_Mutation_p.S172L	NM_001144895.1|NM_001144897.1|NM_021155.3	NP_001138367.1|NP_001138369.1|NP_066978.1	Q9NNX6	CD209_HUMAN	CD209 molecule	333	C-type lectin.				cell-cell recognition|endocytosis|heterophilic cell-cell adhesion|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to membrane|plasma membrane	mannose binding|metal ion binding|peptide antigen binding|receptor activity|virion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	35						CAACAGAGGTGAGCCGTCCAC	0.527000													11	37					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398285	25398285	+	Missense_Mutation	SNP	C	C	G	rs121913530		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:25398285C>G	ENST00000311936.3	-	2	225	c.34G>C	c.(34-36)Ggt>Cgt	p.G12R	KRAS_ENST00000557334.1_Missense_Mutation_p.G12R|KRAS_ENST00000556131.1_Missense_Mutation_p.G12R|KRAS_ENST00000256078.4_Missense_Mutation_p.G12R	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12C(3001)|p.G12S(1288)|p.G12R(789)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12W(3)|p.A11_G12insGA(2)|p.G12Y(2)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			CCTACGCCACCAGCTCCAACT	0.348000	G12C(CALU1_LUNG)|G12C(HCC44_LUNG)|G12C(IALM_LUNG)|G12C(KHM1B_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12C(KYSE410_OESOPHAGUS)|G12C(LU65_LUNG)|G12C(LU99_LUNG)|G12C(MIAPACA2_PANCREAS)|G12C(NCIH1373_LUNG)|G12C(NCIH1792_LUNG)|G12C(NCIH2030_LUNG)|G12C(NCIH2122_LUNG)|G12C(NCIH23_LUNG)|G12C(NCIH358_LUNG)|G12C(OV56_OVARY)|G12C(SW1463_LARGE_INTESTINE)|G12C(SW1573_LUNG)|G12C(SW837_LARGE_INTESTINE)|G12C(UMUC3_URINARY_TRACT)|G12R(CAL62_THYROID)|G12R(HS274T_BREAST)|G12R(HUPT3_PANCREAS)|G12R(KP2_PANCREAS)|G12R(PSN1_PANCREAS)|G12R(TCCPAN2_PANCREAS)|G12S(A549_LUNG)|G12S(KMS20_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12S(LS123_LARGE_INTESTINE)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			5	6					0	0	1	0	0
INCENP	3619	broad.mit.edu	37	11	61919372	61919372	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:61919372C>T	ENST00000394818.3	+	19	2883	c.2681C>T	c.(2680-2682)tCt>tTt	p.S894F	INCENP_ENST00000278849.4_Missense_Mutation_p.S890F	NM_001040694.1	NP_001035784.1	Q9NQS7	INCE_HUMAN	inner centromere protein antigens 135/155kDa	894					chromosome segregation|cytokinesis|mitotic prometaphase	centromeric heterochromatin|condensed chromosome kinetochore|cytosol|microtubule|spindle	protein binding			breast(1)|endometrium(1)|kidney(6)|large_intestine(2)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19						CGCACCAGCTCTGCTGTCTGG	0.607000													29	30					0	0	1	0	0
SPAG16	79582	broad.mit.edu	37	2	214794838	214794838	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:214794838G>A	ENST00000331683.5	+	12	1464	c.1369G>A	c.(1369-1371)Gat>Aat	p.D457N	SPAG16_ENST00000374309.3_Missense_Mutation_p.D363N	NM_024532.4	NP_078808.3	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16	457					cilium assembly	cilium axoneme|flagellar axoneme				endometrium(4)|kidney(1)|large_intestine(15)|lung(27)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	56		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		CTCCTCACTGGATAAAACTAG	0.428000													14	10					0	0	1	0	0
RUNX1T1	862	broad.mit.edu	37	8	92998472	92998472	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:92998472C>T	ENST00000523629.1	-	9	1613	c.1159G>A	c.(1159-1161)Gaa>Aaa	p.E387K	RUNX1T1_ENST00000422361.2_Missense_Mutation_p.E350K|RUNX1T1_ENST00000396218.1_Missense_Mutation_p.E360K|RUNX1T1_ENST00000265814.3_Missense_Mutation_p.E387K|RUNX1T1_ENST00000518844.1_Missense_Mutation_p.E360K|RUNX1T1_ENST00000360348.2_Missense_Mutation_p.E350K|RUNX1T1_ENST00000436581.2_Missense_Mutation_p.E398K|RUNX1T1_ENST00000520724.1_Missense_Mutation_p.E350K	NM_001198626.1|NM_001198630.1|NM_001198633.1|NM_175634.2	NP_001185555.1|NP_001185559.1|NP_001185562.1|NP_783552.1	Q06455	MTG8_HUMAN	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	387					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E398K(1)|p.E350K(1)|p.E387K(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(54)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	86			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TTCAATTCTTCCCGGTCTGCT	0.502000													37	58					0	0	1	0	0
EPHB6	2051	broad.mit.edu	37	7	142563350	142563350	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:142563350G>A	ENST00000392957.2	+	8	1854	c.1067G>A	c.(1066-1068)cGg>cAg	p.R356Q	EPHB6_ENST00000411471.2_Missense_Mutation_p.R79Q|EPHB6_ENST00000442129.1_Missense_Mutation_p.R356Q	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	356	Cys-rich.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity	p.R341L(1)		NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					GGCTTCTACCGGGCCAGTTCC	0.647000													11	11					0	0	1	0	0
OR13C4	138804	broad.mit.edu	37	9	107289444	107289444	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:107289444C>T	ENST00000277216.3	-	1	46	c.47G>A	c.(46-48)gGa>gAa	p.G16E		NM_001001919.1	NP_001001919.1	Q8NGS5	O13C4_HUMAN	olfactory receptor, family 13, subfamily C, member 4	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(2)|lung(14)|skin(1)	18						ACCAGAGAGTCCCAGAAGAAT	0.403000													19	7					0	0	1	0	0
MYO18A	399687	broad.mit.edu	37	17	27401845	27401845	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:27401845G>A	ENST00000527372.1	-	42	6288	c.6108C>T	c.(6106-6108)tcC>tcT	p.S2036S	MYO18A_ENST00000529578.1_5'UTR|MYO18A_ENST00000354329.4_Silent_p.S2036S|TIAF1_ENST00000359450.6_5'UTR|MYO18A_ENST00000531253.1_Silent_p.S2021S|TIAF1_ENST00000408971.2_5'UTR|MYO18A_ENST00000533112.1_Silent_p.S1984S	NM_078471.3	NP_510880.2	Q92614	MY18A_HUMAN	myosin XVIIIA	2036					anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity			NS(1)|cervix(1)|endometrium(6)|kidney(6)|lung(20)|urinary_tract(2)	36			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			GATAACTGTGGGAGTATCGCG	0.612000													7	46					0	0	1	0	0
HERC3	8916	broad.mit.edu	37	4	89588562	89588562	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:89588562C>T	ENST00000402738.1	+	13	1605	c.1366C>T	c.(1366-1368)Cct>Tct	p.P456S	HERC3_ENST00000543130.1_5'UTR|HERC3_ENST00000264345.3_Missense_Mutation_p.P456S	NM_001271602.1|NM_014606.1	NP_001258531.1|NP_055421.1	Q15034	HERC3_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 3	456					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity	p.P456T(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|prostate(2)|skin(2)	45				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		TCCCAAAATCCCTGGGATTGA	0.313000													7	10					0	0	1	0	0
HLA-DMA	3108	broad.mit.edu	37	6	32918392	32918392	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:32918392C>T	ENST00000374843.4	-	2	362	c.277G>A	c.(277-279)Gga>Aga	p.G93R	HLA-DMA_ENST00000395305.3_Intron|HLA-DMA_ENST00000395303.3_Missense_Mutation_p.G93R|HLA-DMA_ENST00000464392.1_Intron|XXbac-BPG181M17.5_ENST00000429234.1_Intron	NM_006120.3	NP_006111.2	Q31604	Q31604_HUMAN	major histocompatibility complex, class II, DM alpha	93						integral to membrane|MHC class II protein complex				kidney(1)|large_intestine(2)|lung(8)	11						GGAGCATCTCCCTGTTCCTGA	0.522000													29	84					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32185834	32185834	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:32185834G>A	ENST00000375023.3	-	9	1700	c.1562C>T	c.(1561-1563)cCc>cTc	p.P521L		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	521	EGF-like 13; calcium-binding (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GTTCAGGCAGGGAGCTGAGGC	0.622000													7	19					0	0	1	0	0
IGHM	3507	broad.mit.edu	37	14	106321212	106321212	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:106321212C>T	ENST00000390559.2	-	0	776																											TCTGGCGGGTCCAGGAGATGG	0.592000													24	33					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189975025	189975025	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:189975025G>A	ENST00000374866.3	-	2	522	c.248C>T	c.(247-249)gCc>gTc	p.A83V		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	83	VWFC.				axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TACAGGGTCGGCACAGTCCAG	0.498000													3	40					0	0	1	0	0
EDNRA	1909	broad.mit.edu	37	4	148441110	148441110	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:148441110C>T	ENST00000324300.5	+	3	1043	c.528C>T	c.(526-528)ctC>ctT	p.L176L	EDNRA_ENST00000339690.5_Intron|EDNRA_ENST00000511804.1_5'UTR|EDNRA_ENST00000506066.1_Intron|EDNRA_ENST00000358556.4_Intron	NM_001957.3	NP_001948.1	P25101	EDNRA_HUMAN	endothelin receptor type A	176					activation of adenylate cyclase activity|artery smooth muscle contraction|cell proliferation|glucose transport|respiratory gaseous exchange	integral to plasma membrane	endothelin-A receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)	17	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.154)	Bosentan(DB00559)	TCCTCAACCTCTGCGCTCTTA	0.458000													35	62					0	0	1	0	0
GSDMA	284110	broad.mit.edu	37	17	38126760	38126760	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:38126760C>T	ENST00000301659.4	+	4	536	c.418C>T	c.(418-420)Ctg>Ttg	p.L140L		NM_178171.4	NP_835465.2	Q96QA5	GSDMA_HUMAN	gasdermin A	140					apoptosis|induction of apoptosis	perinuclear region of cytoplasm				NS(1)|endometrium(2)|large_intestine(3)|lung(1)	7						CCACCCATTCCTGAAGGAGAT	0.567000													16	8					0	0	1	0	0
ENTPD4	9583	broad.mit.edu	37	8	23243516	23243516	+	Silent	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:23243516T>C	ENST00000356206.6	-	13	1876	c.1641A>G	c.(1639-1641)ccA>ccG	p.P547P	LOXL2_ENST00000389131.3_Intron			Q9Y227	ENTP4_HUMAN	ectonucleoside triphosphate diphosphohydrolase 4	0					UDP catabolic process	autophagic vacuole membrane|cytoplasmic vesicle|integral to Golgi membrane	uridine-diphosphatase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	25		Prostate(55;0.114)		Colorectal(74;0.0161)|COAD - Colon adenocarcinoma(73;0.0649)		aacacagCTTTGGacaacccc	0.468000													22	31					0	0	1	0	0
USP39	10713	broad.mit.edu	37	2	85875082	85875082	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:85875082C>T	ENST00000409766.3	+	11	1459	c.1457C>T	c.(1456-1458)aCc>aTc	p.T486I	USP39_ENST00000409470.1_Silent_p.D531D|USP39_ENST00000450066.2_Silent_p.D428D|USP39_ENST00000459775.1_3'UTR|USP39_ENST00000409025.1_Intron|USP39_ENST00000323701.6_Silent_p.D531D	NM_001256726.1	NP_001243655.1	Q53GS9	SNUT2_HUMAN	ubiquitin specific peptidase 39	0					spliceosome assembly|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	19						AATTACAAGACCTCCAGGTGA	0.478000													13	5					0	0	1	0	0
PYHIN1	149628	broad.mit.edu	37	1	158906794	158906794	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:158906794G>A	ENST00000368140.1	+	2	339	c.94G>A	c.(94-96)Gat>Aat	p.D32N	PYHIN1_ENST00000368135.4_Missense_Mutation_p.D32N|PYHIN1_ENST00000392252.3_Missense_Mutation_p.D32N|PYHIN1_ENST00000392254.2_Missense_Mutation_p.D32N|PYHIN1_ENST00000368138.3_Missense_Mutation_p.D32N	NM_152501.4|NM_198928.4|NM_198929.4	NP_689714.2|NP_945146.1|NP_945147.1	Q6K0P9	IFIX_HUMAN	pyrin and HIN domain family, member 1	32	DAPIN.				cell cycle	nuclear speck		p.D32N(3)		breast(2)|endometrium(3)|large_intestine(10)|lung(32)|ovary(3)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	60	all_hematologic(112;0.0378)					ACTGAGTAACGATTTAAAACT	0.338000													9	23					0	0	1	0	0
POU5F1B	5462	broad.mit.edu	37	8	128428510	128428510	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:128428510G>A	ENST00000465342.2	+	2	1556	c.399G>A	c.(397-399)ccG>ccA	p.P133P	CASC8_ENST00000502082.1_RNA|CASC8_ENST00000523825.1_RNA|POU5F1B_ENST00000391675.1_Silent_p.P133P|CASC8_ENST00000501396.1_RNA			Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	133						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			lung(1)|prostate(1)|urinary_tract(1)	3						AGCAAAACCCGGAGAAGTCCC	0.577000													13	10					0	0	1	0	0
REEP4	80346	broad.mit.edu	37	8	21997708	21997708	+	Silent	SNP	G	G	A	rs146312249		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:21997708G>A	ENST00000306306.3	-	3	627	c.159C>T	c.(157-159)atC>atT	p.I53I	REEP4_ENST00000523293.1_Silent_p.I53I|REEP4_ENST00000334530.5_Silent_p.I53I	NM_025232.2	NP_079508.2	Q9H6H4	REEP4_HUMAN	receptor accessory protein 4	53						integral to membrane				kidney(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	7				Colorectal(74;0.00187)|COAD - Colon adenocarcinoma(73;0.061)|READ - Rectum adenocarcinoma(644;0.0993)		TGTCTGTAACGATCTCTGCTG	0.597000													16	35					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11067950	11067950	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:11067950C>T	ENST00000287766.4	+	10	1404	c.983C>T	c.(982-984)tCg>tTg	p.S328L	SLC6A1_ENST00000536032.1_Missense_Mutation_p.S150L	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	328					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	TGCATCAATTCGTGCACCAGC	0.577000													34	54					0	0	1	0	0
CENPJ	55835	broad.mit.edu	37	13	25457454	25457454	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:25457454G>A	ENST00000381884.4	-	17	4063	c.3878C>T	c.(3877-3879)gCc>gTc	p.A1293V	CENPJ_ENST00000545981.1_3'UTR	NM_018451.4	NP_060921.3	Q9HC77	CENPJ_HUMAN	centromere protein J	1293					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			endometrium(5)|kidney(4)|large_intestine(14)|lung(13)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		CTTGAACTGGGCAGTATGTAG	0.348000													34	136					0	0	1	0	0
CR2	1380	broad.mit.edu	37	1	207644123	207644123	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:207644123G>A	ENST00000367057.3	+	7	1453	c.1264G>A	c.(1264-1266)Gaa>Aaa	p.E422K	CR2_ENST00000367058.3_Missense_Mutation_p.E422K|CR2_ENST00000367059.3_Missense_Mutation_p.E422K|CR2_ENST00000458541.2_Missense_Mutation_p.E422K	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	422	Sushi 7.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity	p.E422K(1)		NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						TGGGCAAAAGGAAGATAGACA	0.423000													9	24					0	0	1	0	0
ARHGAP6	395	broad.mit.edu	37	X	11682618	11682618	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:11682618C>T	ENST00000337414.4	-	1	1203	c.331G>A	c.(331-333)Gag>Aag	p.E111K	ARHGAP6_ENST00000380718.1_Missense_Mutation_p.E111K|ARHGAP6_ENST00000380732.3_Missense_Mutation_p.E111K	NM_013427.2	NP_038286.2	O43182	RHG06_HUMAN	Rho GTPase activating protein 6	111					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38						GGTGACTTCTCCTGCGGGGTG	0.652000													7	7					0	0	1	0	0
CNGA2	1260	broad.mit.edu	37	X	150908139	150908139	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:150908139C>T	ENST00000329903.4	+	3	342	c.309C>T	c.(307-309)ctC>ctT	p.L103L		NM_005140.1	NP_005131.1	Q16280	CNGA2_HUMAN	cyclic nucleotide gated channel alpha 2	103					response to stimulus|sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(4)|endometrium(4)|large_intestine(5)|lung(34)|prostate(2)	49	Acute lymphoblastic leukemia(192;6.56e-05)					GGCCTGAACTCCAGACTGTGA	0.552000													14	25					0	0	1	0	0
NEK5	341676	broad.mit.edu	37	13	52667266	52667266	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:52667266G>A	ENST00000355568.4	-	13	1271	c.1132C>T	c.(1132-1134)Cac>Tac	p.H378Y		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	378							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		GGAATAGGGTGATAACTTGGT	0.418000													26	66					0	0	1	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7586934	7586934	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:7586934C>T	ENST00000299492.4	+	3	603	c.215C>T	c.(214-216)gCc>gTc	p.A72V		NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	72					cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		GAGAGAGCAGCCCTCCTGAGC	0.587000													25	53					0	0	1	0	0
WWP1	11059	broad.mit.edu	37	8	87424091	87424091	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:87424091C>T	ENST00000517970.1	+	9	1356	c.1049C>T	c.(1048-1050)aCc>aTc	p.T350I	WWP1_ENST00000265428.4_Missense_Mutation_p.T350I|WWP1_ENST00000349423.2_Missense_Mutation_p.T132I|WWP1_ENST00000341922.2_Missense_Mutation_p.T220I	NM_007013.3	NP_008944.1	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase 1	350	WW 1.				central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			endometrium(3)|kidney(2)|large_intestine(9)|liver(4)|lung(10)|prostate(2)|urinary_tract(1)	31						AACACAGAAACCTTGCCATCA	0.398000													9	11					0	0	1	0	0
ADRA2B	151	broad.mit.edu	37	2	96781235	96781235	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:96781235G>A	ENST00000409345.3	-	1	749	c.654C>T	c.(652-654)tcC>tcT	p.S218S		NM_000682.5	NP_000673.2	P18089	ADA2B_HUMAN	adrenoceptor alpha 2B	218					activation of MAPK activity by adrenergic receptor signaling pathway|activation of protein kinase B activity|blood coagulation|cell-cell signaling|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|negative regulation of epinephrine secretion|negative regulation of norepinephrine secretion|positive regulation of neuron differentiation	integral to plasma membrane	alpha2-adrenergic receptor activity|epinephrine binding|protein binding			endometrium(2)|large_intestine(2)|lung(9)|ovary(3)	16					Bethanidine(DB00217)|Brimonidine(DB00484)|Debrisoquin(DB04840)|Ergotamine(DB00696)|Fenoldopam(DB00800)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Lofexidine(DB04948)|Norepinephrine(DB00368)|Yohimbine(DB01392)	GGGGCTGCTTGGACTCACCCT	0.632000													4	7					0	0	1	0	0
RGS12	6002	broad.mit.edu	37	4	3425306	3425306	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:3425306G>A	ENST00000336727.3	+	13	4076	c.3172G>A	c.(3172-3174)Gag>Aag	p.E1058K	RGS12_ENST00000382788.3_Missense_Mutation_p.E1058K|RGS12_ENST00000344733.5_Missense_Mutation_p.E1058K|RGS12_ENST00000338806.4_Missense_Mutation_p.E410K|RGS12_ENST00000538395.1_Missense_Mutation_p.E400K|RGS12_ENST00000306648.7_Missense_Mutation_p.E456K|RGS12_ENST00000508158.1_3'UTR	NM_002926.3	NP_002917.1	O14924	RGS12_HUMAN	regulator of G-protein signaling 12	1058	RBD 2.					condensed nuclear chromosome|cytoplasm|plasma membrane	GTPase activator activity|receptor signaling protein activity			autonomic_ganglia(1)|breast(4)|endometrium(3)|kidney(2)|large_intestine(9)|lung(16)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		GCCCGTCACGGAGGTGCTGCG	0.627000													11	23					0	0	1	0	0
ANKRD20A4	728747	broad.mit.edu	37	9	69420398	69420398	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:69420398C>T	ENST00000357336.3	+	13	1569	c.1288C>T	c.(1288-1290)Ccc>Tcc	p.P430S		NM_001098805.1	NP_001092275.1	Q4UJ75	A20A4_HUMAN	ankyrin repeat domain 20 family, member A4	430										breast(1)|large_intestine(1)|liver(1)|lung(9)|pancreas(2)|skin(2)	16						TCAGCAATTTCCCAAGAAGCT	0.343000													11	110					0	0	1	0	0
MAGEA12	4111	broad.mit.edu	37	X	151899864	151899864	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:151899864C>T	ENST00000393900.3	-	3	1290	c.937G>A	c.(937-939)Gaa>Aaa	p.E313K	CSAG4_ENST00000361201.4_RNA|MAGEA12_ENST00000393869.3_Missense_Mutation_p.E313K|MAGEA12_ENST00000357916.4_Missense_Mutation_p.E313K	NM_001166386.1	NP_001159858.1	P43365	MAGAC_HUMAN	melanoma antigen family A, 12	313										breast(5)|large_intestine(5)|liver(1)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					ACTCACTCTTCCCCCTCTCTA	0.552000													26	78					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43926885	43926885	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:43926885G>A	ENST00000537548.1	-	8	1595	c.1351C>T	c.(1351-1353)Cgt>Tgt	p.R451C	MATN4_ENST00000372753.1_Missense_Mutation_p.R302C|MATN4_ENST00000372754.1_Missense_Mutation_p.R492C|MATN4_ENST00000372751.4_Missense_Mutation_p.R302C|MATN4_ENST00000372756.1_Missense_Mutation_p.R451C|MATN4_ENST00000353917.5_Missense_Mutation_p.R369C|MATN4_ENST00000360607.5_Missense_Mutation_p.R410C|MATN4_ENST00000342716.4_Missense_Mutation_p.R451C			O95460	MATN4_HUMAN	matrilin 4	492	VWFA 2.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				AGGCCAACACGAGGCACGTTA	0.662000													39	35					0	0	1	0	0
TMEM255A	55026	broad.mit.edu	37	X	119410842	119410842	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:119410842G>A	ENST00000371369.4	-	7	799	c.573C>T	c.(571-573)atC>atT	p.I191I	TMEM255A_ENST00000371352.1_Silent_p.I51I|TMEM255A_ENST00000309720.5_Silent_p.I215I|TMEM255A_ENST00000440464.1_Intron	NM_001104544.1	NP_001098014.1			transmembrane protein 255A																		AGAGGTGGATGATATCTTGGC	0.557000													41	66					0	0	1	0	0
FILIP1L	11259	broad.mit.edu	37	3	99568524	99568524	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:99568524C>T	ENST00000331335.5	-	5	2466	c.1996G>A	c.(1996-1998)Gaa>Aaa	p.E666K	CMSS1_ENST00000421999.2_Intron|FILIP1L_ENST00000354552.3_Missense_Mutation_p.E666K|FILIP1L_ENST00000487087.1_Missense_Mutation_p.E242K|FILIP1L_ENST00000471562.1_Missense_Mutation_p.E426K|CMSS1_ENST00000496116.1_Intron|FILIP1L_ENST00000476723.1_Intron|FILIP1L_ENST00000383694.2_Missense_Mutation_p.E426K	NM_001042459.1	NP_001035924.1	Q4L180	FIL1L_HUMAN	filamin A interacting protein 1-like	666						cytoplasm|membrane|myosin complex|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	35						TTGTCTCGTTCATTAGCATAC	0.378000													24	47					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16026231	16026231	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:16026231C>T	ENST00000350896.3	-	4	563	c.366G>A	c.(364-366)gaG>gaA	p.E122E	MSR1_ENST00000355282.2_Silent_p.E122E|MSR1_ENST00000381998.4_Silent_p.E122E|MSR1_ENST00000445506.2_Silent_p.E140E|MSR1_ENST00000536385.1_Intron|MSR1_ENST00000262101.5_Silent_p.E122E	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	122					cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		GGATTCTCTTCTCCATGTTGC	0.378000													30	62					0	0	1	0	0
TTLL6	284076	broad.mit.edu	37	17	46847144	46847144	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:46847144G>A	ENST00000393382.3	-	14	2497	c.2356C>T	c.(2356-2358)Ctc>Ttc	p.L786F	TTLL6_ENST00000433608.2_Missense_Mutation_p.L479F	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	738						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						AAGAAGGAGAGCTTCCCACTC	0.507000													25	25					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719003	140719003	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140719003G>A	ENST00000394576.2	+	1	465	c.465G>A	c.(463-465)aaG>aaA	p.K155K	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCCTCTTAAGAATGCGCATG	0.488000													24	30					0	0	1	0	0
SLC38A4	55089	broad.mit.edu	37	12	47173411	47173411	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:47173411C>T	ENST00000447411.1	-	9	906	c.700G>A	c.(700-702)Gtg>Atg	p.V234M	SLC38A4_ENST00000266579.4_Missense_Mutation_p.V234M	NM_001143824.1	NP_001137296.1	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	234					cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	21	Lung SC(27;0.192)|Renal(347;0.236)					ACAAAAAACACCATGCAGGTA	0.373000													38	44					0	0	1	0	0
CFHR3	10878	broad.mit.edu	37	1	196748929	196748929	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:196748929A>T	ENST00000471440.2	+	3	330	c.256A>T	c.(256-258)Aaa>Taa	p.K86*	CFHR3_ENST00000391985.3_Nonsense_Mutation_p.K86*|CFHR3_ENST00000367425.4_Nonsense_Mutation_p.K86*					complement factor H-related 3											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|lung(6)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	18						GTCCTTAGGAAAATGTTATTT	0.284000													4	7					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155736000	155736000	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:155736000G>A	ENST00000437809.1	-	21	3386	c.3264C>T	c.(3262-3264)tcC>tcT	p.S1088S	GON4L_ENST00000271883.5_Silent_p.S1088S|GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000368331.1_Silent_p.S1088S|GON4L_ENST00000361040.5_Silent_p.S1088S			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	1088					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GCAAAGTCTGGGACTCAGACA	0.572000													19	25					0	0	1	0	0
GATA1	2623	broad.mit.edu	37	X	48652530	48652530	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:48652530C>T	ENST00000376670.3	+	6	1312	c.1201C>T	c.(1201-1203)Ccc>Tcc	p.P401S	GATA1_ENST00000376665.3_Intron	NM_002049.3	NP_002040.1	P15976	GATA1_HUMAN	GATA binding protein 1 (globin transcription factor 1)	401					basophil differentiation|eosinophil differentiation|erythrocyte development|megakaryocyte differentiation|platelet aggregation|platelet formation|positive regulation of anti-apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|regulation of glycoprotein biosynthetic process|transcription from RNA polymerase II promoter	nuclear membrane|nucleolus|nucleoplasm	C2H2 zinc finger domain binding|RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(259)|large_intestine(8)|lung(9)|prostate(1)	283						CCCCATGCCCCCCACCACCAG	0.642000			"""Mis, F"""		megakaryoblastic leukemia of Downs Syndrome								9	9					0	0	1	0	0
VRTN	55237	broad.mit.edu	37	14	74824766	74824766	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:74824766G>A	ENST00000256362.4	+	2	1521	c.1280G>A	c.(1279-1281)aGg>aAg	p.R427K		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	427					transposition, DNA-mediated		DNA binding|transposase activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						TTCAAACGCAGGTTCCCTGGC	0.572000													23	25					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140744147	140744147	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140744147T>G	ENST00000518069.1	+	1	250	c.250T>G	c.(250-252)Ttg>Gtg	p.L84V	PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGCGGCAGCTTGGTCACCGC	0.587000													36	50					0	0	1	0	0
UGGT2	55757	broad.mit.edu	37	13	96506702	96506702	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:96506702G>A	ENST00000376747.3	-	35	4106	c.4036C>T	c.(4036-4038)Cga>Tga	p.R1346*		NM_020121.3	NP_064506.3	Q9NYU1	UGGG2_HUMAN	UDP-glucose glycoprotein glucosyltransferase 2	1346	Glucosyltransferase.				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(17)|lung(20)|ovary(3)|pancreas(1)|prostate(4)|urinary_tract(2)	60						TCGAAATCTCGAAGTTCTTTT	0.368000													24	11					0	0	1	0	0
CDH5	1003	broad.mit.edu	37	16	66436590	66436590	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:66436590C>T	ENST00000341529.3	+	12	2021	c.1873C>T	c.(1873-1875)Cgg>Tgg	p.R625W	CDH5_ENST00000539168.1_Missense_Mutation_p.R64W	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	625					adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		GCGGCGGCTCCGGAAGCAGGC	0.701000													4	10					0	0	1	0	0
CTC-260E6.6	0	broad.mit.edu	37	19	20369281	20369281	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:20369281G>A	ENST00000593655.1	-	0	199																											GGCATAGTACGAAATTGGGAT	0.378000													31	40					0	0	1	0	0
EDA	1896	broad.mit.edu	37	X	68836180	68836180	+	Missense_Mutation	SNP	G	G	A	rs41539891		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:68836180G>A	ENST00000374552.4	+	1	270	c.28G>A	c.(28-30)Gaa>Aaa	p.E10K	EDA_ENST00000338901.3_Missense_Mutation_p.E10K|EDA_ENST00000502251.1_3'UTR|EDA_ENST00000525810.1_Missense_Mutation_p.E10K|EDA_ENST00000524573.1_Missense_Mutation_p.E10K|EDA_ENST00000527388.1_Missense_Mutation_p.E10K|EDA_ENST00000374553.2_Missense_Mutation_p.E10K	NM_001399.4	NP_001390.1	Q92838	EDA_HUMAN	ectodysplasin A	10					cell differentiation|ectoderm development|immune response|positive regulation of NF-kappaB transcription factor activity|signal transduction	collagen|cytoskeleton|membrane fraction	tumor necrosis factor receptor binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(2)|urinary_tract(1)	14						GGAGCGCAGGGAACTCCTGCC	0.721000													7	11					0	0	1	0	0
LRFN2	57497	broad.mit.edu	37	6	40399671	40399671	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:40399671G>A	ENST00000338305.6	-	2	1724	c.1182C>T	c.(1180-1182)tcC>tcT	p.S394S		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	394						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					CTGAGAGGCGGGACTTGGGGG	0.672000													20	57					0	0	1	0	0
TJP3	27134	broad.mit.edu	37	19	3733899	3733899	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:3733899C>T	ENST00000541714.2	+	7	1328	c.866C>T	c.(865-867)tCg>tTg	p.S289L	TJP3_ENST00000382008.3_Missense_Mutation_p.S289L|TJP3_ENST00000589378.1_Missense_Mutation_p.S298L|TJP3_ENST00000587686.1_Missense_Mutation_p.S308L|TJP3_ENST00000539908.2_Missense_Mutation_p.S253L|TJP3_ENST00000262968.9_Missense_Mutation_p.S308L	NM_001267560.1	NP_001254489.1	O95049	ZO3_HUMAN	tight junction protein 3	289						tight junction	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0118)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCGACAGCTCGCCATTGGAG	0.577000													13	23					0	0	1	0	0
OR2G2	81470	broad.mit.edu	37	1	247752474	247752474	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:247752474G>A	ENST00000320065.1	+	1	813	c.813G>A	c.(811-813)agG>agA	p.R271R	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	271					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GTAGATCCAGGGACCAGGGCA	0.473000													29	64					0	0	1	0	0
CDCA4	55038	broad.mit.edu	37	14	105477549	105477549	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:105477549C>T	ENST00000336219.3	-	2	873	c.718G>A	c.(718-720)Gag>Aag	p.E240K	CDCA4_ENST00000392590.3_Missense_Mutation_p.E240K	NM_017955.3	NP_060425.2	Q9BXL8	CDCA4_HUMAN	cell division cycle associated 4	240						nucleus				endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	6		all_cancers(154;0.0798)|Melanoma(154;0.155)|all_epithelial(191;0.183)	OV - Ovarian serous cystadenocarcinoma(23;0.00778)|all cancers(16;0.00936)|Epithelial(46;0.0227)	Epithelial(152;0.142)		GCTCAGGTCTCCACCAGGATC	0.692000													5	11					0	0	1	0	0
TRBV6-5	28602	broad.mit.edu	37	7	142180696	142180696	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:142180696G>A	ENST00000390368.2	-	0	228																											GGGTCTTGTCGATACCAGGAC	0.507000													34	309					0	0	1	0	0
CCDC68	80323	broad.mit.edu	37	18	52608311	52608311	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:52608311G>A	ENST00000591504.1	-	4	395	c.121C>T	c.(121-123)Cga>Tga	p.R41*	CCDC68_ENST00000337363.4_Nonsense_Mutation_p.R41*|CCDC68_ENST00000432185.1_Nonsense_Mutation_p.R41*	NM_025214.2	NP_079490.1	Q9H2F9	CCD68_HUMAN	coiled-coil domain containing 68	41										breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|stomach(1)	14				Colorectal(16;0.0256)|READ - Rectum adenocarcinoma(59;0.21)		AGAGTAGTTCGAATCTAGAGA	0.353000													4	16					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25331747	25331747	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:25331747C>T	ENST00000546682.1	+	0	453				SNORD116-19_ENST00000384729.1_RNA|SNHG14_ENST00000553108.1_RNA|SNHG14_ENST00000549804.2_RNA	NR_003361.1																						ATACCGTCATCCTCGTCGAAC	0.468000													47	110					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156593013	156593013	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:156593013T>C	ENST00000302938.4	-	1	262	c.167A>G	c.(166-168)aAa>aGa	p.K56R		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	56						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CTCTCCCTTTTTGTTTATCTG	0.478000													19	34					0	0	1	0	0
MIOX	55586	broad.mit.edu	37	22	50925838	50925838	+	Silent	SNP	C	C	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:50925838C>A	ENST00000395732.3	+	2	62	c.40C>A	c.(40-42)Cga>Aga	p.R14R	MIOX_ENST00000216075.6_Silent_p.R14R|MIOX_ENST00000395733.3_Silent_p.R14R			Q9UGB7	MIOX_HUMAN	myo-inositol oxygenase	14					inositol catabolic process	cytoplasm|inclusion body	aldo-keto reductase (NADP) activity|ferric iron binding|inositol oxygenase activity	p.R14*(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	13		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CCTGGTCTACCGACCTGATGT	0.597000													12	75					1.5842e-08	1.59935e-08	1	1	0
JAM2	58494	broad.mit.edu	37	21	27071098	27071098	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr21:27071098G>A	ENST00000480456.1	+	5	1054	c.504G>A	c.(502-504)tgG>tgA	p.W168*	JAM2_ENST00000425221.2_Nonsense_Mutation_p.W132*|JAM2_ENST00000400532.1_Nonsense_Mutation_p.W168*|JAM2_ENST00000312957.5_Nonsense_Mutation_p.W168*	NM_001270407.1|NM_021219.3	NP_001257336.1|NP_067042.1	P57087	JAM2_HUMAN	junctional adhesion molecule 2	168	Ig-like C2-type.				blood coagulation|cell-cell adhesion|leukocyte migration	integral to plasma membrane|tight junction				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(12)|prostate(1)|stomach(1)|urinary_tract(1)	19						AATACACATGGTTTAAGGATG	0.453000													17	17					0	0	1	0	0
SIMC1	375484	broad.mit.edu	37	5	175772343	175772343	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:175772343C>T	ENST00000443967.1	+	12	2921	c.2514C>T	c.(2512-2514)gtC>gtT	p.V838V	SIMC1_ENST00000332772.4_Silent_p.V299V|SIMC1_ENST00000430704.2_Silent_p.V423V|SIMC1_ENST00000341199.6_Silent_p.V423V					SUMO-interacting motifs containing 1																		AGCCTCTTGTCCCCCAACTCC	0.557000													16	32					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129070779	129070779	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:129070779A>T	ENST00000274487.4	+	22	3594	c.3449A>T	c.(3448-3450)aAt>aTt	p.N1150I	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	1150					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		ATTAATGTAAATACCATAACA	0.348000													16	33					0	0	1	0	0
COL4A6	1288	broad.mit.edu	37	X	107417842	107417842	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:107417842C>T	ENST00000394872.2	-	31	3200	c.2969G>A	c.(2968-2970)gGa>gAa	p.G990E	COL4A6_ENST00000545689.1_Missense_Mutation_p.G989E|COL4A6_ENST00000538570.1_Missense_Mutation_p.G989E|COL4A6_ENST00000334504.7_Missense_Mutation_p.G989E|COL4A6_ENST00000372216.4_Missense_Mutation_p.G990E			Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	990	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding	p.G989E(1)		breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						ACCAGCCTCTCCTTTGTCACC	0.542000									Alport syndrome with Diffuse Leiomyomatosis				6	23					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74536432	74536432	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:74536432G>A	ENST00000321288.5	+	4	737	c.737G>A	c.(736-738)gGg>gAg	p.G246E	CCDC33_ENST00000398814.3_Missense_Mutation_p.G43E			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	246	C2.						protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						ACCCTCCATGGGGCTACCAAC	0.617000													25	43					0	0	1	0	0
ITGB1BP2	26548	broad.mit.edu	37	X	70523173	70523173	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:70523173G>A	ENST00000538820.1	+	4	665	c.325G>A	c.(325-327)Gaa>Aaa	p.E109K	ITGB1BP2_ENST00000373829.3_Missense_Mutation_p.E127K			Q9UKP3	ITBP2_HUMAN	integrin beta 1 binding protein (melusin) 2	127					muscle organ development|signal transduction		SH3 domain binding			breast(1)|endometrium(5)|large_intestine(2)|lung(5)|ovary(1)	14	Renal(35;0.156)					AATGGCATTGGAACAGAAGGA	0.483000													6	13					0	0	1	0	0
ARHGAP29	9411	broad.mit.edu	37	1	94643191	94643191	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:94643191C>T	ENST00000260526.6	-	22	3064	c.2882G>A	c.(2881-2883)gGa>gAa	p.G961E	ARHGAP29_ENST00000482481.1_5'UTR	NM_004815.3	NP_004806.3	Q52LW3	RHG29_HUMAN	Rho GTPase activating protein 29	961					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			NS(1)|breast(5)|endometrium(6)|kidney(2)|large_intestine(9)|lung(19)|ovary(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	54		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		ATCACATTTTCCTAACGCATT	0.368000													16	17					0	0	1	0	0
PKD1	5310	broad.mit.edu	37	16	2163265	2163265	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:2163265G>T	ENST00000262304.4	-	12	3090	c.2882C>A	c.(2881-2883)tCg>tAg	p.S961*	RP11-304L19.4_ENST00000568795.1_RNA|PKD1_ENST00000423118.1_Nonsense_Mutation_p.S961*	NM_001009944.2	NP_001009944.2	P98161	PKD1_HUMAN	polycystic kidney disease 1 (autosomal dominant)	961	PKD 4.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|kidney(6)|lung(34)|prostate(4)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						GACCATGTCCGAGCCGGCCTC	0.607000													30	56					2.87052e-16	2.92596e-16	1	1	0
BPIFC	254240	broad.mit.edu	37	22	32843249	32843249	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:32843249G>C	ENST00000397452.1	-	4	434	c.324C>G	c.(322-324)aaC>aaG	p.N108K	BPIFC_ENST00000432451.2_5'UTR|BPIFC_ENST00000534972.1_5'UTR|BPIFC_ENST00000300399.3_Missense_Mutation_p.N108K			Q8NFQ6	BPIL2_HUMAN	BPI fold containing family C	108						extracellular region	lipopolysaccharide binding|phospholipid binding										CAGTGCCATGGTTGGTTAGCG	0.448000													18	33					0	0	1	0	0
DLGAP2	9228	broad.mit.edu	37	8	1497492	1497492	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:1497492C>T	ENST00000421627.2	+	2	767	c.633C>T	c.(631-633)ccC>ccT	p.P211P		NM_004745.3	NP_004736.2	Q9P1A6	DLGP2_HUMAN	discs, large (Drosophila) homolog-associated protein 2	290					neuron-neuron synaptic transmission	cell junction|neurofilament|postsynaptic density|postsynaptic membrane	protein binding			breast(1)|endometrium(6)|lung(31)|prostate(3)	41		Ovarian(12;0.0271)|Hepatocellular(245;0.0838)|Colorectal(14;0.0846)		BRCA - Breast invasive adenocarcinoma(11;0.000169)|READ - Rectum adenocarcinoma(644;0.171)		AGCCCCGGCCCGGCATGAGCA	0.706000													18	31					0	0	1	0	0
WNT10B	7480	broad.mit.edu	37	12	49359907	49359907	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:49359907C>T	ENST00000301061.4	-	5	1489	c.1141G>A	c.(1141-1143)Gtt>Att	p.V381I	WNT10B_ENST00000403957.1_3'UTR|WNT10B_ENST00000407467.1_3'UTR	NM_003394.3	NP_003385.2	O00744	WN10B_HUMAN	wingless-type MMTV integration site family, member 10B	381					axis specification|bone trabecula formation|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|chondrocyte differentiation|female gonad development|hemopoietic stem cell proliferation|midbrain-hindbrain boundary development|myoblast cell differentiation involved in skeletal muscle regeneration|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|neuron differentiation|positive regulation of anagen|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cell proliferation|positive regulation of epithelial cell differentiation|positive regulation of osteoblast differentiation|protein stabilization|regulation of skeletal muscle tissue development|skeletal muscle fiber development|smoothened signaling pathway|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			central_nervous_system(1)|large_intestine(5)|lung(12)|prostate(1)|skin(4)	23						CACTCTGTAACCTTGCACTCA	0.582000													15	12					0	0	1	0	0
ADAMTS4	9507	broad.mit.edu	37	1	161161902	161161902	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:161161902C>T	ENST00000367996.4	-	8	2468	c.2040G>A	c.(2038-2040)ggG>ggA	p.G680G		NM_005099.4	NP_005090.3	O75173	ATS4_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 4	680	Cys-rich.				proteolysis|skeletal system development	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|protease binding|zinc ion binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(20)|ovary(4)|prostate(3)|skin(1)|urinary_tract(1)	43	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			CAGAACCGTCCCCTCCGCACA	0.537000											OREG0013940	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	44					0	0	1	0	0
MOV10	4343	broad.mit.edu	37	1	113232121	113232121	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:113232121C>T	ENST00000369644.1	+	5	1287	c.258C>T	c.(256-258)cgC>cgT	p.R86R	MOV10_ENST00000413052.2_Silent_p.R142R|MOV10_ENST00000468624.1_3'UTR|MOV10_ENST00000369645.1_Silent_p.R142R|MOV10_ENST00000357443.2_Silent_p.R142R			Q9HCE1	MOV10_HUMAN	Mov10, Moloney leukemia virus 10, homolog (mouse)	142					mRNA cleavage involved in gene silencing by miRNA|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body	ATP binding|helicase activity|protein binding|RNA binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(15)|ovary(5)|prostate(1)|skin(3)|urinary_tract(3)	38	Lung SC(450;0.246)	all_cancers(81;3.31e-11)|all_epithelial(167;5.69e-10)|all_lung(203;3.73e-05)|Breast(1374;0.000525)|Lung NSC(69;0.000954)|Ovarian(761;0.0367)|Lung SC(238;0.114)		OV - Ovarian serous cystadenocarcinoma(397;3.99e-67)|all cancers(265;1e-62)|Epithelial(280;4.78e-61)|Lung(183;0.0234)|Colorectal(144;0.0686)|READ - Rectum adenocarcinoma(129;0.0929)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|BRCA - Breast invasive adenocarcinoma(282;0.24)		TCCTTATCCGCCTGGATTTGA	0.592000													27	37					0	0	1	0	0
CBS	875	broad.mit.edu	37	21	44486419	44486419	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr21:44486419C>T	ENST00000398165.3	-	5	644	c.385G>A	c.(385-387)Gat>Aat	p.D129N	CBS_ENST00000544202.1_Missense_Mutation_p.D41N|CBS_ENST00000470912.1_5'UTR|CBS_ENST00000398158.1_Missense_Mutation_p.D129N|CBS_ENST00000352178.5_Missense_Mutation_p.D129N|CBS_ENST00000398168.1_Missense_Mutation_p.D129N|CBS_ENST00000359624.3_Missense_Mutation_p.D129N	NM_000071.2	NP_000062.1	P35520	CBS_HUMAN	cystathionine-beta-synthase	129					cysteine biosynthetic process from serine|cysteine biosynthetic process via cystathionine|homocysteine catabolic process|hydrogen sulfide biosynthetic process|L-cysteine catabolic process|L-serine catabolic process	cytosol|nucleolus	cystathionine beta-synthase activity|heme binding|protein homodimerization activity|pyridoxal phosphate binding|ubiquitin protein ligase binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(8)	17					L-Cysteine(DB00151)|L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|S-Adenosylmethionine(DB00118)	CGCTCAGCATCCTCAATCATC	0.647000													31	15					0	0	1	0	0
ZNF334	55713	broad.mit.edu	37	20	45130646	45130646	+	Silent	SNP	C	C	T	rs144394680	byFrequency	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:45130646C>T	ENST00000457685.2	-	6	2541	c.1218G>A	c.(1216-1218)acG>acA	p.T406T	ZNF334_ENST00000593880.1_Silent_p.T467T|ZNF334_ENST00000347606.4_Silent_p.T444T			Q9HCZ1	ZN334_HUMAN	zinc finger protein 334	444					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)				GGGCTGATTTCGTACATAAAA	0.378000													29	39					0	0	1	0	0
IFNG	3458	broad.mit.edu	37	12	68551978	68551978	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:68551978C>T	ENST00000229135.3	-	2	307	c.176G>A	c.(175-177)tGg>tAg	p.W59*	IFNG-AS1_ENST00000536914.1_RNA	NM_000619.2	NP_000610.2	P01579	IFNG_HUMAN	interferon, gamma	59					cell cycle arrest|interferon-gamma-mediated signaling pathway|negative regulation of interleukin-17 production|negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of metanephric nephron tubule epithelial cell differentiation|negative regulation of smooth muscle cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity|positive regulation of fructose 1,6-bisphosphate metabolic process|positive regulation of interleukin-12 production|positive regulation of interleukin-23 production|positive regulation of killing of cells of other organism|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mesenchymal cell proliferation|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation of STAT protein|positive regulation of smooth muscle cell apoptosis|positive regulation of tumor necrosis factor (ligand) superfamily member 11 production|positive regulation of tyrosine phosphorylation of Stat1 protein|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|regulation of insulin secretion|regulation of interferon-gamma-mediated signaling pathway|response to virus	extracellular space	cytokine activity|interferon-gamma receptor binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(5)|prostate(1)	12			Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.018)	GBM - Glioblastoma multiforme(7;0.000829)	Glucosamine(DB01296)|Interferon gamma-1b(DB00033)|Simvastatin(DB00641)	TACCTCTTTCCAATTCTTCAA	0.348000													8	15					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39463875	39463875	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:39463875G>A	ENST00000265707.5	+	3	227	c.182G>A	c.(181-183)gGa>gAa	p.G61E	ADAM18_ENST00000520772.1_Missense_Mutation_p.G61E|ADAM18_ENST00000379866.1_Missense_Mutation_p.G61E|ADAM18_ENST00000541111.1_5'UTR	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	61					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			CTACATCTCGGAAAACAGTAA	0.284000													6	18					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	75684184	75684184	+	Missense_Mutation	SNP	C	C	T	rs143004355	byFrequency	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:75684184C>T	ENST00000370855.5	-	17	1633	c.1520G>A	c.(1519-1521)cGa>cAa	p.R507Q	SLC44A5_ENST00000535611.1_Missense_Mutation_p.R377Q|SLC44A5_ENST00000370859.3_Missense_Mutation_p.R507Q	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	507						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						CCGTATGGCTCGTCCAAATGC	0.433000													44	61					0	0	1	0	0
SERPINB4	6318	broad.mit.edu	37	18	61310838	61310838	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:61310838C>T	ENST00000341074.5	-	2	90		c.e2-1		SERPINB4_ENST00000356424.6_Splice_Site	NM_002974.2	NP_002965.1			serpin peptidase inhibitor, clade B (ovalbumin), member 4											breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(22)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	42						TCTGGAACTCCTGGAAAAGCA	0.358000													31	36					0	0	1	0	0
TESPA1	9840	broad.mit.edu	37	12	55356418	55356418	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:55356418C>T	ENST00000524622.1	-	7	1511	c.850G>A	c.(850-852)Gaa>Aaa	p.E284K	TESPA1_ENST00000449076.1_Missense_Mutation_p.E422K|TESPA1_ENST00000532804.1_Missense_Mutation_p.E284K|TESPA1_ENST00000316577.8_Missense_Mutation_p.E422K|TESPA1_ENST00000531122.1_Missense_Mutation_p.E284K	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	422																	GGATGGGTTTCCGTATTGGTG	0.493000													35	59					0	0	1	0	0
NUDCD3	23386	broad.mit.edu	37	7	44530080	44530080	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:44530080G>A	ENST00000355451.6	-	1	399	c.120C>T	c.(118-120)ttC>ttT	p.F40F		NM_015332.3	NP_056147.2	Q8IVD9	NUDC3_HUMAN	NudC domain containing 3	40										endometrium(2)|large_intestine(1)|lung(3)|skin(1)	7						GCAAGCGATAGAAGTCTGTCT	0.657000													3	5					0	0	1	0	0
CDH11	1009	broad.mit.edu	37	16	64981596	64981596	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:64981596C>T	ENST00000268603.4	-	13	2916	c.2301G>A	c.(2299-2301)ttG>ttA	p.L767L	CDH11_ENST00000394156.3_3'UTR|CDH11_ENST00000566827.1_Silent_p.L641L	NM_001797.2	NP_001788.2	P55287	CAD11_HUMAN	cadherin 11, type 2, OB-cadherin (osteoblast)	767					adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(19)|lung(40)|ovary(3)|prostate(3)|skin(2)|urinary_tract(2)	88		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		AATCATAGTCCAAGTCTGAAT	0.458000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			21	38					0	0	1	0	0
FAM221A	340277	broad.mit.edu	37	7	23729011	23729011	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:23729011C>T	ENST00000344962.4	+	3	452	c.363C>T	c.(361-363)ccC>ccT	p.P121P	FAM221A_ENST00000409994.3_Silent_p.P63P|FAM221A_ENST00000409653.1_Silent_p.P63P|FAM221A_ENST00000409192.3_Silent_p.P121P	NM_199136.3	NP_954587.2	A4D161	CG046_HUMAN	family with sequence similarity 221, member A	121																	GTAGCCAGCCCATTCGCTGCA	0.493000													9	30					0	0	1	0	0
OR2W1	26692	broad.mit.edu	37	6	29012249	29012249	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:29012249C>T	ENST00000377175.1	-	1	768	c.704G>A	c.(703-705)cGa>cAa	p.R235Q		NM_030903.3	NP_112165.1	Q9Y3N9	OR2W1_HUMAN	olfactory receptor, family 2, subfamily W, member 1	235					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|skin(1)	23						CATTGCTTTTCGCTGGCTTGC	0.408000													25	64					0	0	1	0	0
FAM71B	153745	broad.mit.edu	37	5	156589659	156589659	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:156589659C>T	ENST00000302938.4	-	2	1712	c.1617G>A	c.(1615-1617)agG>agA	p.R539R		NM_130899.2	NP_570969.2	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	539						nucleus				NS(3)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(10)|lung(32)|ovary(4)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CCCTGAGGCTCCTTAAAAAAG	0.458000													42	46					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38622851	38622851	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:38622851G>A	ENST00000413689.1	-	17	2992	c.2799C>T	c.(2797-2799)ctC>ctT	p.L933L	SCN5A_ENST00000443581.1_Silent_p.L933L|SCN5A_ENST00000333535.4_Silent_p.L933L|SCN5A_ENST00000450102.2_Silent_p.L933L|SCN5A_ENST00000451551.2_Silent_p.L933L|SCN5A_ENST00000414099.2_Silent_p.L933L|SCN5A_ENST00000449557.2_Silent_p.L933L|SCN5A_ENST00000425664.1_Silent_p.L933L|SCN5A_ENST00000423572.2_Silent_p.L933L|SCN5A_ENST00000455624.2_Silent_p.L933L	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	933					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	AGGCCAGGAAGAGATTCAGGA	0.577000													3	3					0	0	1	0	0
OR52R1	119695	broad.mit.edu	37	11	4825161	4825161	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:4825161G>A	ENST00000380382.1	-	1	686	c.687C>T	c.(685-687)atC>atT	p.I229I	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron|OR52R1_ENST00000356069.2_Silent_p.I150I			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	150					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCAGCATCACGATGGTCCCCA	0.572000													29	36					0	0	1	0	0
MAGEB6	158809	broad.mit.edu	37	X	26212923	26212923	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:26212923C>T	ENST00000379034.1	+	2	1109	c.960C>T	c.(958-960)atC>atT	p.I320I		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	320	MAGE.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						ATGATGGGATCCTGCATTCAA	0.493000													65	99					0	0	1	0	0
NSRP1	84081	broad.mit.edu	37	17	28507991	28507991	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:28507991G>C	ENST00000247026.5	+	6	637	c.574G>C	c.(574-576)Gtt>Ctt	p.V192L	NSRP1_ENST00000540900.3_3'UTR	NM_001261467.1|NM_032141.3	NP_001248396.1|NP_115517.1	Q9H0G5	NSRP1_HUMAN	nuclear speckle splicing regulatory protein 1	192					developmental process|nucleocytoplasmic transport|regulation of alternative nuclear mRNA splicing, via spliceosome	nuclear speck|ribonucleoprotein complex	mRNA binding|protein binding			autonomic_ganglia(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)	14						AAATCAAGCAGTTGGTGAAGA	0.363000													34	34					0	0	1	0	0
CACNA1D	776	broad.mit.edu	37	3	53834309	53834309	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:53834309G>A	ENST00000288139.3	+	42	5135	c.5017G>A	c.(5017-5019)Gaa>Aaa	p.E1673K	CACNA1D_ENST00000544977.1_Missense_Mutation_p.E32K|CACNA1D_ENST00000422281.2_Missense_Mutation_p.E1638K|CACNA1D_ENST00000350061.5_Missense_Mutation_p.E1653K	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit	1653					axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	CATTGGGCCAGAAATCCGGCG	0.493000													32	58					0	0	1	0	0
PIK3C2G	5288	broad.mit.edu	37	12	18644418	18644418	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:18644418G>A	ENST00000433979.1	+	19	2712	c.2596G>A	c.(2596-2598)Gag>Aag	p.E866K	PIK3C2G_ENST00000538779.1_Missense_Mutation_p.E907K|PIK3C2G_ENST00000266497.5_Missense_Mutation_p.E866K	NM_004570.4	NP_004561.3	O75747	P3C2G_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma	866					cell communication|phosphatidylinositol-mediated signaling	membrane|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			breast(5)|central_nervous_system(6)|endometrium(2)|kidney(4)|large_intestine(8)|lung(31)|ovary(2)|prostate(1)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	66		Hepatocellular(102;0.194)				CAGACTAGAAGAGTTCTTTCA	0.338000													9	19					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52505446	52505446	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:52505446G>A	ENST00000261839.7	-	34	4241	c.4080C>T	c.(4078-4080)taC>taT	p.Y1360Y		NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	1360						myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		GCATTCCAAGGTACTCCTTGG	0.448000													10	27					0	0	1	0	0
GRK4	2868	broad.mit.edu	37	4	3024149	3024149	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:3024149A>G	ENST00000398052.4	+	10	1284	c.941A>G	c.(940-942)aAg>aGg	p.K314R	GRK4_ENST00000398051.4_Missense_Mutation_p.K282R|GRK4_ENST00000504933.1_Missense_Mutation_p.K314R|GRK4_ENST00000345167.6_Missense_Mutation_p.K282R	NM_182982.2	NP_892027.2	P32298	GRK4_HUMAN	G protein-coupled receptor kinase 4	314	Protein kinase.					cell cortex	ATP binding|G-protein coupled receptor kinase activity|signal transducer activity			lung(1)|upper_aerodigestive_tract(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		AGAGACTTGAAGCCTGAGAAT	0.448000													26	51					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19486730	19486730	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:19486730G>A	ENST00000375267.2	-	39	5455	c.5452C>T	c.(5452-5454)Ctt>Ttt	p.L1818F	UBR4_ENST00000375217.2_Missense_Mutation_p.L1818F|UBR4_ENST00000375226.2_Missense_Mutation_p.L1818F|UBR4_ENST00000375254.3_Missense_Mutation_p.L1818F			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	1818					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GCATCCATAAGGAAATTAAGC	0.453000													14	10					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150327158	150327158	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:150327158C>T	ENST00000328902.5	-	2	289	c.73G>A	c.(73-75)Gag>Aag	p.E25K	GIMAP6_ENST00000493969.1_Missense_Mutation_p.E25K	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	25							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCTGACAGCTCCAGCACAGGA	0.468000													33	72					0	0	1	0	0
MSR1	4481	broad.mit.edu	37	8	16012615	16012615	+	Missense_Mutation	SNP	G	G	A	rs73665227	byFrequency	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:16012615G>A	ENST00000350896.3	-	6	1053	c.856C>T	c.(856-858)Ccc>Tcc	p.P286S	MSR1_ENST00000355282.2_Missense_Mutation_p.P286S|MSR1_ENST00000381998.4_Missense_Mutation_p.P286S|MSR1_ENST00000445506.2_Missense_Mutation_p.P304S|MSR1_ENST00000536385.1_Missense_Mutation_p.P60S|MSR1_ENST00000262101.5_Missense_Mutation_p.P286S	NM_138715.2|NM_138716.2	NP_619729.1|NP_619730.1	P21757	MSRE_HUMAN	macrophage scavenger receptor 1	286	Collagen-like.				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(7)|lung(14)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	37				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		TCTCCAGTGGGACCTCGATCT	0.403000													10	13					0	0	1	0	0
MIR526B	574468	broad.mit.edu	37	19	54197697	54197697	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:54197697G>A	ENST00000384848.1	+	0	51					NR_030190.1																						TGAAAGAAGAGAAAGTGCTTC	0.418000													14	20					0	0	1	0	0
OR4C3	256144	broad.mit.edu	37	11	48347189	48347189	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:48347189C>T	ENST00000319856.4	+	1	718	c.697C>T	c.(697-699)Ctg>Ttg	p.L233L		NM_001004702.1	NP_001004702.1	Q8NH37	OR4C3_HUMAN	olfactory receptor, family 4, subfamily C, member 3	206					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(18)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	32						TTTAATCTGCCTGTTGAACTT	0.512000													4	31					0	0	1	0	0
TRHDE	29953	broad.mit.edu	37	12	73046885	73046885	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:73046885G>A	ENST00000261180.4	+	17	2894	c.2798G>A	c.(2797-2799)cGa>cAa	p.R933Q		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	933					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						CCACATGGTCGAGACCTTGCC	0.378000													15	11					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070708	9070708	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:9070708G>A	ENST00000397910.4	-	3	16941	c.16738C>T	c.(16738-16740)Ctt>Ttt	p.L5580F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5582	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCCCAGGGAAGGATACCCTGT	0.507000													49	75					0	0	1	0	0
OR5B17	219965	broad.mit.edu	37	11	58126056	58126056	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:58126056G>A	ENST00000357377.3	-	1	486	c.487C>T	c.(487-489)Cgc>Tgc	p.R163C		NM_001005489.1	NP_001005489.1	Q8NGF7	OR5BH_HUMAN	olfactory receptor, family 5, subfamily B, member 17	163					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|autonomic_ganglia(1)|endometrium(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AAAGAGAGGCGAAATGTATCT	0.413000													8	18					0	0	1	0	0
MAOB	4129	broad.mit.edu	37	X	43656435	43656435	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:43656435G>A	ENST00000378069.4	-	6	702	c.555C>T	c.(553-555)ttC>ttT	p.F185F	MAOB_ENST00000536181.1_Silent_p.F169F|MAOB_ENST00000538942.1_Silent_p.F169F	NM_000898.4	NP_000889.3	P27338	AOFB_HUMAN	monoamine oxidase B	185					xenobiotic metabolic process	integral to membrane|mitochondrial outer membrane	electron carrier activity|primary amine oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(2)|skin(5)	21					Amantadine(DB00915)|Bupropion(DB01156)|Carbidopa(DB00190)|Citalopram(DB00215)|Dopamine(DB00988)|Entacapone(DB00494)|Furazolidone(DB00614)|Ginkgo biloba(DB01381)|Ibuprofen(DB01050)|Imipramine(DB00458)|Iproniazid(DB04818)|Isocarboxazid(DB01247)|Levodopa(DB01235)|Maprotiline(DB00934)|Meclizine(DB00737)|Moclobemide(DB01171)|Nicotine(DB00184)|Pargyline(DB01626)|Phenelzine(DB00780)|Phentermine(DB00191)|Rasagiline(DB01367)|Selegiline(DB01037)|Tranylcypromine(DB00752)	CATACCACAGGAACCAGAGAG	0.493000													18	23					0	0	1	0	0
PLCZ1	89869	broad.mit.edu	37	12	18837133	18837133	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:18837133C>T	ENST00000447925.2	-	14	1935	c.1666G>A	c.(1666-1668)Ggt>Agt	p.G556S	PLCZ1_ENST00000534932.1_Missense_Mutation_p.G39S|PLCZ1_ENST00000541695.1_3'UTR|PLCZ1_ENST00000435379.1_Missense_Mutation_p.G363S|PLCZ1_ENST00000266505.7_Missense_Mutation_p.G558S|PLCZ1_ENST00000538330.1_Missense_Mutation_p.G340S|PLCZ1_ENST00000539875.1_Missense_Mutation_p.G365S	NM_033123.2	NP_149114.2	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	558	C2.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					AAACCTTGACCTTCAACAACA	0.333000													10	24					0	0	1	0	0
DMXL2	23312	broad.mit.edu	37	15	51783792	51783792	+	Silent	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:51783792G>T	ENST00000251076.5	-	20	5223	c.4936C>A	c.(4936-4938)Cga>Aga	p.R1646R	DMXL2_ENST00000449909.3_Silent_p.R1010R|DMXL2_ENST00000543779.2_Silent_p.R1646R|RP11-707P17.1_ENST00000561007.1_RNA	NM_001174116.1|NM_015263.3	NP_001167587.1|NP_056078.2	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1646						cell junction|synaptic vesicle membrane	Rab GTPase binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(26)|liver(1)|lung(28)|ovary(7)|prostate(7)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	101				all cancers(107;0.00494)		ATGCATCTTCGAAGCGTGTTA	0.383000													31	30					1.45844e-13	1.48035e-13	1	1	0
TRAPPC8	22878	broad.mit.edu	37	18	29429670	29429670	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:29429670G>T	ENST00000283351.4	-	25	3929	c.3594C>A	c.(3592-3594)ttC>ttA	p.F1198L	TRAPPC8_ENST00000582539.1_Missense_Mutation_p.F1144L	NM_014939.3	NP_055754.2	Q9Y2L5	TPPC8_HUMAN	trafficking protein particle complex 8	1198					ER to Golgi vesicle-mediated transport	cis-Golgi network				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(6)|large_intestine(7)|liver(2)|lung(13)|ovary(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TTCGATAAAAGAAGTCTGCAC	0.318000													7	13					8.12818e-05	8.15716e-05	1	1	0
ALPK1	80216	broad.mit.edu	37	4	113303619	113303619	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:113303619C>T	ENST00000458497.1	+	4	466	c.187C>T	c.(187-189)Cct>Tct	p.P63S	ALPK1_ENST00000504176.2_Intron|ALPK1_ENST00000177648.9_Missense_Mutation_p.P63S	NM_001102406.1|NM_025144.3	NP_001095876.1|NP_079420.3	Q96QP1	ALPK1_HUMAN	alpha-kinase 1	63							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(11)|lung(20)|ovary(6)|prostate(2)|urinary_tract(1)	53		Ovarian(17;0.0446)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00325)		GCCCTTCGTGCCTGAAAAGTG	0.517000													16	24					0	0	1	0	0
TRAV4	28689	broad.mit.edu	37	14	22205121	22205121	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:22205121G>A	ENST00000390426.2	+	0	252																											CAAGGACCACGATTTATTATT	0.448000													11	10					0	0	1	0	0
MTM1	4534	broad.mit.edu	37	X	149828167	149828167	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:149828167G>A	ENST00000370396.2	+	12	1345	c.1291G>A	c.(1291-1293)Gat>Aat	p.D431N	MTM1_ENST00000413012.2_Missense_Mutation_p.D394N|MTM1_ENST00000306167.7_3'UTR|MTM1_ENST00000543350.1_Missense_Mutation_p.D316N|MTM1_ENST00000542741.1_Missense_Mutation_p.D336N	NM_000252.2	NP_000243.1	Q13496	MTM1_HUMAN	myotubularin 1	431	Myotubularin phosphatase.		D -> N (in XCNM).		endosome to lysosome transport|intermediate filament organization|mitochondrion distribution|mitochondrion morphogenesis|phosphatidylinositol dephosphorylation|protein transport|regulation of vacuole organization	filopodium|late endosome|plasma membrane|ruffle	intermediate filament binding|phosphatidylinositol binding|phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein tyrosine phosphatase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|liver(1)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Acute lymphoblastic leukemia(192;6.56e-05)					AAACCACACCGATGCTGACCG	0.333000													6	35					0	0	1	0	0
ABCD4	5826	broad.mit.edu	37	14	74756199	74756199	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:74756199G>A	ENST00000356924.4	-	14	1586	c.1443C>T	c.(1441-1443)gtC>gtT	p.V481V	ABCD4_ENST00000298816.7_Silent_p.V377V|AC005519.4_ENST00000554532.2_RNA	NM_005050.3	NP_005041.1	O14678	ABCD4_HUMAN	ATP-binding cassette, sub-family D (ALD), member 4	481	ABC transporter.					ATP-binding cassette (ABC) transporter complex|integral to membrane|peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			cervix(2)|endometrium(3)|kidney(3)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00153)		AGTCGGGGTAGACCTCCTTCA	0.552000													3	13					0	0	1	0	0
AKR1B10	57016	broad.mit.edu	37	7	134216714	134216714	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:134216714C>T	ENST00000359579.4	+	3	609	c.289C>T	c.(289-291)Ctc>Ttc	p.L97F	AKR1B10_ENST00000475559.1_3'UTR	NM_020299.4	NP_064695.3	O60218	AK1BA_HUMAN	aldo-keto reductase family 1, member B10 (aldose reductase)	97					cellular aldehyde metabolic process|digestion|steroid metabolic process	cytoplasm	aldo-keto reductase (NADP) activity|protein binding			NS(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(9)|skin(5)	20						TGAGAAGACCCTCAAGGACCT	0.463000													29	40					0	0	1	0	0
FAM171B	165215	broad.mit.edu	37	2	187626905	187626905	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:187626905C>T	ENST00000304698.5	+	8	2039	c.1836C>T	c.(1834-1836)agC>agT	p.S612S		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	612						integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						GTCAACAGAGCCTGCCATCCC	0.488000													19	5					0	0	1	0	0
LDLRAD4	753	broad.mit.edu	37	18	13621234	13621234	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:13621234G>A	ENST00000361205.4	+	5	968	c.300G>A	c.(298-300)ccG>ccA	p.P100P	LDLRAD4_ENST00000585931.1_Silent_p.P23P|LDLRAD4_ENST00000587757.1_Silent_p.P63P|LDLRAD4_ENST00000359446.5_Silent_p.P100P|LDLRAD4_ENST00000586765.1_Silent_p.P63P|LDLRAD4_ENST00000399848.3_Silent_p.P100P	NM_001276249.1|NM_181481.3	NP_001263178.1|NP_852146.1			low density lipoprotein receptor class A domain containing 4									p.P100P(1)|p.P63P(1)									TCAACCGCCCGAACCAGAGCC	0.622000													26	49					0	0	1	0	0
ZNF81	347344	broad.mit.edu	37	X	47755315	47755315	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:47755315G>A	ENST00000376954.1	+	5	621	c.253G>A	c.(253-255)Gaa>Aaa	p.E85K	ZNF81_ENST00000338637.7_Missense_Mutation_p.E85K			P51508	ZNF81_HUMAN	zinc finger protein 81	85	KRAB.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(1)|lung(1)|skin(1)	4		all_lung(315;0.0973)				ATTGGAAGGGGAAGCCCCACA	0.493000													3	10					0	0	1	0	0
CETN1	1068	broad.mit.edu	37	18	580847	580847	+	Missense_Mutation	SNP	G	G	A	rs143489830		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:580847G>A	ENST00000327228.3	+	1	481	c.439G>A	c.(439-441)Gac>Aac	p.D147N		NM_004066.1	NP_004057.1	Q12798	CETN1_HUMAN	centrin, EF-hand protein, 1	147	EF-hand 4.				cell division|mitosis	spindle pole	ATP binding|ATP-dependent helicase activity|calcium ion binding|nucleic acid binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(6)|lung(9)|ovary(2)|upper_aerodigestive_tract(2)	25						GGAGATGATCGACGAAGCTGA	0.537000													13	36					0	0	1	0	0
CDO1	1036	broad.mit.edu	37	5	115151999	115151999	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:115151999C>T	ENST00000250535.4	-	1	652	c.96G>A	c.(94-96)gaG>gaA	p.E32E	CDO1_ENST00000502631.1_Intron	NM_001801.2	NP_001792.2	Q16878	CDO1_HUMAN	cysteine dioxygenase type 1	32					inflammatory response|sulfur amino acid biosynthetic process|taurine biosynthetic process	cytosol	cysteine dioxygenase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|skin(5)	11		all_cancers(142;0.0046)|all_epithelial(76;0.000161)|Prostate(80;0.0132)|Ovarian(225;0.0776)		OV - Ovarian serous cystadenocarcinoma(64;7.8e-08)|Epithelial(69;7.32e-07)|all cancers(49;3.24e-05)	L-Cysteine(DB00151)|NADH(DB00157)	TGGCCTGCACCTCCTCTACAT	0.587000													71	76					0	0	1	0	0
RASSF4	83937	broad.mit.edu	37	10	45477989	45477989	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:45477989C>T	ENST00000334940.6	+	4	239	c.105C>T	c.(103-105)atC>atT	p.I35I	RASSF4_ENST00000472561.1_3'UTR|RASSF4_ENST00000340258.4_Silent_p.I53I|RASSF4_ENST00000374417.2_Silent_p.I53I			Q9H2L5	RASF4_HUMAN	Ras association (RalGDS/AF-6) domain family member 4	53					cell cycle|signal transduction		protein binding			NS(1)|endometrium(2)|large_intestine(6)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16						CTCTGATCATCGAGGGGCTCC	0.637000													6	3					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3432543	3432543	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:3432543G>A	ENST00000520002.1	-	11	1826	c.1271C>T	c.(1270-1272)aCc>aTc	p.T424I	CSMD1_ENST00000542608.1_Missense_Mutation_p.T423I|CSMD1_ENST00000539096.1_Missense_Mutation_p.T423I|CSMD1_ENST00000537824.1_Missense_Mutation_p.T423I|CSMD1_ENST00000602723.1_Missense_Mutation_p.T424I|CSMD1_ENST00000400186.3_Missense_Mutation_p.T424I|CSMD1_ENST00000602557.1_Missense_Mutation_p.T424I			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	424	CUB 3.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		ATTAGGGGAGGTAATGACGCC	0.502000													10	21					0	0	1	0	0
FBXL17	64839	broad.mit.edu	37	5	107216802	107216802	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:107216802C>T	ENST00000542267.1	-	8	2307	c.1901G>A	c.(1900-1902)gGa>gAa	p.G634E	FBXL17_ENST00000496714.1_Missense_Mutation_p.G236E|FBXL17_ENST00000359660.5_Missense_Mutation_p.G236E	NM_001163315.2	NP_001156787.2	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	634										endometrium(1)|large_intestine(4)|lung(1)	6		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		CAGGGTGGCTCCTTGGTCTGT	0.453000													37	50					0	0	1	0	0
PDZD4	57595	broad.mit.edu	37	X	153069941	153069941	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:153069941C>T	ENST00000164640.4	-	8	1368	c.1177G>A	c.(1177-1179)Gag>Aag	p.E393K	PDZD4_ENST00000393758.2_Missense_Mutation_p.E318K|PDZD4_ENST00000544474.1_Missense_Mutation_p.E284K	NM_032512.2	NP_115901.2	Q76G19	PDZD4_HUMAN	PDZ domain containing 4	393						cell cortex				breast(3)|cervix(1)|endometrium(5)|lung(13)|skin(1)	23	all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCCAGGCTCTCGTTGCGGTTG	0.637000													13	28					0	0	1	0	0
JADE2	23338	broad.mit.edu	37	5	133909384	133909384	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:133909384C>T	ENST00000395003.1	+	10	1663	c.1484C>T	c.(1483-1485)gCc>gTc	p.A495V	PHF15_ENST00000282605.4_Missense_Mutation_p.A495V|PHF15_ENST00000361895.2_Missense_Mutation_p.A495V|PHF15_ENST00000402835.1_Intron	NM_015288.4	NP_056103.4	Q9NQC1	JADE2_HUMAN		495					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			ACGAAACACGCCATCTGCAAA	0.517000													16	21					0	0	1	0	0
SLC27A6	28965	broad.mit.edu	37	5	128321020	128321020	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:128321020G>A	ENST00000262462.4	+	2	1686	c.676G>A	c.(676-678)Gga>Aga	p.G226R	SLC27A6_ENST00000506176.1_Missense_Mutation_p.G226R|SLC27A6_ENST00000395266.1_Missense_Mutation_p.G226R			Q9Y2P4	S27A6_HUMAN	solute carrier family 27 (fatty acid transporter), member 6	226					long-chain fatty acid transport|transmembrane transport|very long-chain fatty acid metabolic process	integral to membrane|sarcolemma	fatty acid transporter activity|long-chain fatty acid-CoA ligase activity|nucleotide binding			NS(2)|endometrium(1)|kidney(3)|large_intestine(11)|liver(1)|lung(20)|prostate(1)|skin(4)|stomach(1)	44		all_cancers(142;0.0483)|Prostate(80;0.055)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Epithelial(69;0.171)|OV - Ovarian serous cystadenocarcinoma(64;0.186)		TTTTACCTCTGGAACAACAGG	0.428000													4	5					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7580988	7580988	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:7580988C>G	ENST00000379802.3	+	23	4906	c.4565C>G	c.(4564-4566)aCg>aGg	p.T1522R	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1522	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AGTAGTGCGACGGAGACAATA	0.473000													28	92					0	0	1	0	0
PTGFR	5737	broad.mit.edu	37	1	78958666	78958666	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:78958666G>A	ENST00000370756.3	+	2	475	c.238G>A	c.(238-240)Ggc>Agc	p.G80S	PTGFR_ENST00000370757.3_Missense_Mutation_p.G80S|PTGFR_ENST00000370758.1_Missense_Mutation_p.G80S	NM_001039585.1	NP_001034674.1	P43088	PF2R_HUMAN	prostaglandin F receptor (FP)	80					parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			breast(6)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	33				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	TGATTTCTTTGGCCATCTCAT	0.418000													18	39					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113649118	113649118	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:113649118C>T	ENST00000297405.5	-	22	3887	c.3643G>A	c.(3643-3645)Gaa>Aaa	p.E1215K	CSMD3_ENST00000352409.3_Missense_Mutation_p.E1215K|CSMD3_ENST00000343508.3_Missense_Mutation_p.E1175K|CSMD3_ENST00000455883.2_Missense_Mutation_p.E1111K	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1215	Sushi 6.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						GATGTTCCTTCCAGTCGATAA	0.502000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	36					0	0	1	0	0
KSR2	283455	broad.mit.edu	37	12	117977619	117977619	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:117977619G>A	ENST00000425217.1	-	10	1559	c.1505C>T	c.(1504-1506)tCg>tTg	p.S502L	KSR2_ENST00000302438.5_Missense_Mutation_p.S228L|KSR2_ENST00000545002.1_5'UTR|KSR2_ENST00000339824.5_Missense_Mutation_p.S531L	NM_173598.4	NP_775869.3	Q6VAB6	KSR2_HUMAN	kinase suppressor of ras 2	531					intracellular signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein serine/threonine kinase activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(25)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	67	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGGTGCTGGCGAGGAGGGCGT	0.632000													21	35					0	0	1	0	0
MASP2	10747	broad.mit.edu	37	1	11103511	11103511	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:11103511G>A	ENST00000400897.3	-	5	641	c.626C>T	c.(625-627)tCc>tTc	p.S209F		NM_006610.3	NP_006601.2	O00187	MASP2_HUMAN	mannan-binding lectin serine peptidase 2	209	CUB 2.				complement activation, classical pathway|complement activation, lectin pathway|proteolysis	extracellular region	calcium ion binding|calcium-dependent protein binding|serine-type endopeptidase activity			biliary_tract(1)|endometrium(2)|large_intestine(6)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.071)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.12e-07)|COAD - Colon adenocarcinoma(227;7.07e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|Kidney(185;0.000722)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)|STAD - Stomach adenocarcinoma(313;0.192)		AGTGCAACTGGAGAGTTTGGG	0.587000													3	6					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111711374	111711374	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:111711374T>C	ENST00000435970.1	-	8	1254	c.438A>G	c.(436-438)atA>atG	p.I146M	REV3L_ENST00000368802.3_Missense_Mutation_p.I224M|REV3L_ENST00000368805.1_Missense_Mutation_p.I224M|REV3L_ENST00000358835.3_Missense_Mutation_p.I224M			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	224					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CACCTTCCAATATTAAAGAGC	0.308000								DNA polymerases (catalytic subunits)					15	7					0	0	1	0	0
ACHE	43	broad.mit.edu	37	7	100490067	100490067	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:100490067C>T	ENST00000302913.4	-	3	1579	c.1441G>A	c.(1441-1443)Gag>Aag	p.E481K	ACHE_ENST00000428317.1_Missense_Mutation_p.E481K|ACHE_ENST00000419336.2_Missense_Mutation_p.E393K|ACHE_ENST00000412389.1_Missense_Mutation_p.E481K|ACHE_ENST00000241069.5_Missense_Mutation_p.E481K|ACHE_ENST00000411582.1_Missense_Mutation_p.E481K	NM_015831.2	NP_056646.1	P22303	ACES_HUMAN	acetylcholinesterase	481					acetylcholine catabolic process in synaptic cleft|amyloid precursor protein metabolic process|cell adhesion|cell proliferation|choline metabolic process|DNA replication|muscle organ development|neurotransmitter biosynthetic process|osteoblast development|positive regulation of protein secretion|regulation of axonogenesis|regulation of dendrite morphogenesis|response to wounding|synapse assembly	anchored to membrane|axon|basal lamina|cell junction|cell surface|dendrite|endoplasmic reticulum lumen|extracellular space|Golgi apparatus|neuromuscular junction|nucleus|perinuclear region of cytoplasm|postsynaptic membrane|presynaptic membrane|synaptic cleft	acetylcholine binding|acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|collagen binding|laminin-1 binding|protein homodimerization activity|serine hydrolase activity			large_intestine(3)|lung(7)|skin(3)|urinary_tract(3)	16	Lung NSC(181;0.041)|all_lung(186;0.0581)				Ambenonium(DB01122)|Atropine(DB00572)|Choline(DB00122)|Decamethonium(DB01245)|Demecarium bromide(DB00944)|Donepezil(DB00843)|Edrophonium(DB01010)|Ephedrine(DB01364)|Galantamine(DB00674)|Gallamine Triethiodide(DB00483)|Isoflurophate(DB00677)|Neostigmine(DB01400)|Physostigmine(DB00981)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Tacrine(DB00382)|Tubocurarine(DB01199)	AACTCGATCTCGTAGCCGTGG	0.612000													15	29					0	0	1	0	0
KLKB1	3818	broad.mit.edu	37	4	187158078	187158078	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:187158078C>T	ENST00000264690.6	+	5	659	c.472C>T	c.(472-474)Cac>Tac	p.H158Y	KLKB1_ENST00000513864.1_Missense_Mutation_p.H158Y	NM_000892.3	NP_000883.2	P03952	KLKB1_HUMAN	kallikrein B, plasma (Fletcher factor) 1	158	Apple 2.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(15)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	40		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		GCAAACATTTCACAAGGCAGA	0.403000													8	12					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126792921	126792921	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:126792921G>A	ENST00000274473.6	+	26	3601	c.3334G>A	c.(3334-3336)Gac>Aac	p.D1112N	MEGF10_ENST00000503335.2_Missense_Mutation_p.D1112N	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	1112	Necessary for formation of large intracellular vacuoles.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		TTGTCATTATGACCTGCTGCC	0.512000													21	24					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22383122	22383122	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:22383122C>T	ENST00000328795.4	+	1	741	c.650C>T	c.(649-651)tCc>tTc	p.S217F	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	217					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTTCTGGCTTCCTATGCAGTC	0.502000													18	51					0	0	1	0	0
C14orf39	317761	broad.mit.edu	37	14	60923774	60923774	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:60923774C>T	ENST00000321731.3	-	15	1378	c.1219G>A	c.(1219-1221)Gat>Aat	p.D407N		NM_174978.2	NP_777638.2	Q08AQ4	Q08AQ4_HUMAN	chromosome 14 open reading frame 39	407										breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(108;0.0448)		TCATCACTATCATTTTCTACT	0.348000													23	42					0	0	1	0	0
PPP2R5E	5529	broad.mit.edu	37	14	63851225	63851225	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:63851225G>A	ENST00000337537.3	-	12	1741	c.1139C>T	c.(1138-1140)tCt>tTt	p.S380F	PPP2R5E_ENST00000422769.2_Missense_Mutation_p.S304F|PPP2R5E_ENST00000555899.1_Missense_Mutation_p.S380F|PPP2R5E_ENST00000553266.1_5'UTR	NM_006246.2	NP_006237.1	Q16537	2A5E_HUMAN	protein phosphatase 2, regulatory subunit B', epsilon isoform	380					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|soft_tissue(1)	15				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		GATGACGTTAGAGTTTTCTTC	0.363000													12	26					0	0	1	0	0
CCDC129	223075	broad.mit.edu	37	7	31682348	31682348	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:31682348C>A	ENST00000319386.3	+	11	1913	c.920C>A	c.(919-921)cCa>cAa	p.P307Q	CCDC129_ENST00000409210.1_Missense_Mutation_p.P363Q|CCDC129_ENST00000407970.3_Missense_Mutation_p.P455Q|CCDC129_ENST00000451887.2_Missense_Mutation_p.P481Q			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	455										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						GGTAGAAAGCCAAGAGATCAG	0.512000													12	24					2.80697e-09	2.83721e-09	1	1	0
VWA3A	146177	broad.mit.edu	37	16	22166979	22166979	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:22166979C>T	ENST00000389397.4	+	33	3665	c.803C>T	c.(802-804)tCc>tTc	p.S268F	VWA3A_ENST00000389398.5_Missense_Mutation_p.S1166F|VWA3A_ENST00000563755.1_Missense_Mutation_p.S268F			A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	1166						extracellular region				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|skin(1)	7				GBM - Glioblastoma multiforme(48;0.0439)		CAGGCCCAATCCTTCAGGTAT	0.577000													38	39					0	0	1	0	0
SIN3B	23309	broad.mit.edu	37	19	16980669	16980669	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:16980669C>T	ENST00000379803.1	+	14	2315	c.2301C>T	c.(2299-2301)ccC>ccT	p.P767P	SIN3B_ENST00000248054.5_Silent_p.P735P|SIN3B_ENST00000595541.1_Silent_p.P325P	NM_015260.2	NP_056075.1	O75182	SIN3B_HUMAN	SIN3 transcription regulator family member B	767					cellular lipid metabolic process|transcription, DNA-dependent	nucleoplasm	protein binding			endometrium(4)|kidney(2)|large_intestine(8)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	26						CGCACAAGCCCCTGGACGATG	0.647000													15	30					0	0	1	0	0
EPHA3	2042	broad.mit.edu	37	3	89259034	89259034	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:89259034G>A	ENST00000336596.2	+	3	403	c.178G>A	c.(178-180)Gaa>Aaa	p.E60K	EPHA3_ENST00000494014.1_Missense_Mutation_p.E60K|EPHA3_ENST00000452448.2_Missense_Mutation_p.E60K	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	60						extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		TGGTGTGGATGAACATTACAC	0.448000										TSP Lung(6;0.00050)			7	14					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24873720	24873720	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:24873720G>T	ENST00000396432.2	-	26	5984	c.5498C>A	c.(5497-5499)tCa>tAa	p.S1833*		NM_020824.3	NP_065875.3	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1832	Interaction with CTNNA1.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						GTTTACAGCTGAAAGTTCAGA	0.507000													18	6					6.94344e-10	7.02665e-10	1	1	0
PCDHB3	56132	broad.mit.edu	37	5	140481345	140481345	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140481345C>T	ENST00000231130.2	+	1	1112	c.1112C>T	c.(1111-1113)tCt>tTt	p.S371F	AC005754.7_ENST00000607216.1_RNA	NM_018937.2	NP_061760.1	Q9Y5E6	PCDB3_HUMAN		371	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	72			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TTCAGTGTTTCTGATCTAGAC	0.458000													15	51					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993283	140993283	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:140993283C>T	ENST00000285879.4	+	4	379	c.93C>T	c.(91-93)tcC>tcT	p.S31S	MAGEC1_ENST00000406005.2_5'UTR	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	31							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					GGGAGGACTCCCAGTCTCCTC	0.582000										HNSCC(15;0.026)			33	60					0	0	1	0	0
USP29	57663	broad.mit.edu	37	19	57640389	57640389	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:57640389G>A	ENST00000254181.4	+	4	800	c.346G>A	c.(346-348)Gat>Aat	p.D116N	USP29_ENST00000598197.1_Missense_Mutation_p.D116N	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	116					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATCTGATGATGATTGGAGTGT	0.353000													12	26					0	0	1	0	0
BSN	8927	broad.mit.edu	37	3	49695236	49695236	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:49695236C>T	ENST00000296452.4	+	5	8361	c.8247C>T	c.(8245-8247)atC>atT	p.I2749I		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	2749					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GCATCCAGATCGTCACCCCAG	0.627000													17	26					0	0	1	0	0
WDR66	144406	broad.mit.edu	37	12	122399963	122399963	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:122399963C>T	ENST00000288912.4	+	15	3241	c.2387C>T	c.(2386-2388)cCc>cTc	p.P796L	WDR66_ENST00000397454.2_Missense_Mutation_p.P796L|WDR66_ENST00000545752.1_3'UTR	NM_144668.5	NP_653269.3	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	796							calcium ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(11)|liver(2)|lung(13)|ovary(2)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		GGCTGCTATCCCACCTGCATG	0.498000													30	45					0	0	1	0	0
DIAPH1	1729	broad.mit.edu	37	5	140955826	140955826	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140955826C>T	ENST00000253811.6	-	14	1572	c.1432G>A	c.(1432-1434)Gaa>Aaa	p.E478K	DIAPH1_ENST00000398562.2_Missense_Mutation_p.E469K|DIAPH1_ENST00000398566.3_Missense_Mutation_p.E469K|DIAPH1_ENST00000520569.1_Missense_Mutation_p.E424K|DIAPH1_ENST00000518047.1_Missense_Mutation_p.E469K|DIAPH1_ENST00000389054.3_Missense_Mutation_p.E478K|DIAPH1_ENST00000398557.4_Missense_Mutation_p.E478K|DIAPH1_ENST00000389057.5_Missense_Mutation_p.E469K			O60610	DIAP1_HUMAN	diaphanous-related formin 1	478					regulation of microtubule-based process|sensory perception of sound	cytoplasm|cytoskeleton|ruffle membrane	actin binding|receptor binding|Rho GTPase binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(12)|pancreas(1)|skin(2)|stomach(2)	23			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTTTGGCTTCAGATTTCTCC	0.348000													14	29					0	0	1	0	0
TUBA4A	7277	broad.mit.edu	37	2	220115176	220115176	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:220115176C>G	ENST00000392088.2	-	4	1755	c.1200G>C	c.(1198-1200)gaG>gaC	p.E400D	TUBA4A_ENST00000248437.4_Missense_Mutation_p.E415D	NM_001278552.1	NP_001265481.1	P68366	TBA4A_HUMAN	tubulin, alpha 4a	415					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|platelet activation|platelet degranulation|protein polymerization	cytosol|extracellular region|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	20		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGAACTCACCCTCCTCCATGC	0.597000													39	21					0	0	1	0	0
IGHV3-9	28451	broad.mit.edu	37	14	106552566	106552566	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:106552566C>T	ENST00000390600.2	-	0	152																											CCCCCAGACTCCACCAGCTGC	0.542000													9	46					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118344383	118344383	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:118344383C>T	ENST00000534358.1	+	3	2532	c.2509C>T	c.(2509-2511)Cct>Tct	p.P837S	KMT2A_ENST00000389506.5_Missense_Mutation_p.P837S|KMT2A_ENST00000354520.4_Missense_Mutation_p.P837S	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		TCCTCTCTTCCCTTGGTTTAC	0.507000													14	19					0	0	1	0	0
KRT76	51350	broad.mit.edu	37	12	53170615	53170615	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:53170615C>A	ENST00000332411.2	-	1	514	c.461G>T	c.(460-462)gGa>gTa	p.G154V		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	154	Head.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TTCCTGAATTCCCCCAGGAAA	0.582000													11	16					5.50884e-06	5.53176e-06	1	1	0
CSF1	1435	broad.mit.edu	37	1	110460044	110460044	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:110460044C>T	ENST00000329608.6	+	4	746	c.355C>T	c.(355-357)Ctg>Ttg	p.L119L	CSF1_ENST00000420111.2_Silent_p.L119L|CSF1_ENST00000369802.3_Silent_p.L119L|CSF1_ENST00000344188.5_Silent_p.L119L|CSF1_ENST00000369801.1_Silent_p.L119L|CSF1_ENST00000526001.1_3'UTR	NM_000757.5|NM_172211.3	NP_000748.3|NP_757350.1	P09603	CSF1_HUMAN	colony stimulating factor 1 (macrophage)	119					cell proliferation|developmental process involved in reproduction|macrophage differentiation|monocyte activation|osteoclast differentiation|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of cellular protein metabolic process|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|positive regulation of macrophage differentiation|positive regulation of monocyte differentiation|positive regulation of mononuclear cell proliferation|positive regulation of protein kinase activity	extracellular space|integral to membrane|perinuclear region of cytoplasm|plasma membrane|receptor complex	cytokine activity|growth factor activity|macrophage colony-stimulating factor receptor binding|protein homodimerization activity			breast(1)|endometrium(3)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20		all_epithelial(167;3.58e-05)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Acute lymphoblastic leukemia(138;0.204)		Lung(183;0.0238)|Colorectal(144;0.112)|all cancers(265;0.117)|Epithelial(280;0.127)|LUSC - Lung squamous cell carcinoma(189;0.135)		CTCTTTGAGGCTGAAGAGCTG	0.542000													64	125					0	0	1	0	0
LINC00477	144360	broad.mit.edu	37	12	24736811	24736811	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:24736811G>A	ENST00000483544.1	-	0	291					NR_029451.2																						GCTGCCCTAGGAAACGAAGTA	0.527000													19	28					0	0	1	0	0
TBX22	50945	broad.mit.edu	37	X	79279631	79279631	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:79279631C>T	ENST00000442340.1	+	4	556	c.66C>T	c.(64-66)atC>atT	p.I22I	TBX22_ENST00000373291.1_Silent_p.I22I|TBX22_ENST00000373294.5_Silent_p.I142I|TBX22_ENST00000373296.3_Silent_p.I142I	NM_001109878.1|NM_001109879.1	NP_001103348.1|NP_001103349.1	Q9Y458	TBX22_HUMAN	T-box 22	142					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(13)|lung(38)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	65						ATGTGGCCATCGATGTGGTGC	0.527000													21	24					0	0	1	0	0
MS4A1	931	broad.mit.edu	37	11	60230003	60230003	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:60230003G>A	ENST00000534668.1	+	2	445	c.156G>A	c.(154-156)ttG>ttA	p.L52L	MS4A1_ENST00000528313.1_Intron|MS4A1_ENST00000389939.2_Silent_p.L52L|MS4A1_ENST00000532073.1_Silent_p.L52L|MS4A1_ENST00000534503.1_3'UTR|MS4A1_ENST00000345732.4_Silent_p.L52L	NM_152866.2	NP_690605.1	P11836	CD20_HUMAN	membrane-spanning 4-domains, subfamily A, member 1	52					B cell activation|immune response	integral to plasma membrane				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(10)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24					Ibritumomab(DB00078)|Rituximab(DB00073)|Tositumomab(DB00081)	CTAAGACTTTGGGGGTAAGTC	0.488000													13	20					0	0	1	0	0
ACSBG2	81616	broad.mit.edu	37	19	6147630	6147630	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:6147630C>T	ENST00000588304.1	+	3	537	c.91C>T	c.(91-93)Ctg>Ttg	p.L31L	ACSBG2_ENST00000591403.1_Silent_p.L81L|ACSBG2_ENST00000586696.1_Silent_p.L81L|ACSBG2_ENST00000588485.1_5'UTR|ACSBG2_ENST00000252669.5_Silent_p.L81L			Q5FVE4	ACBG2_HUMAN	acyl-CoA synthetase bubblegum family member 2	81					cell differentiation|fatty acid metabolic process|multicellular organismal development|spermatogenesis	membrane|microsome|mitochondrion	acyl-CoA thioesterase activity|ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(3)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GTGGGAAATTCTGAATTTCAA	0.423000													34	60					0	0	1	0	0
SYCP1	6847	broad.mit.edu	37	1	115488946	115488946	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:115488946G>A	ENST00000369522.3	+	26	2431	c.2191G>A	c.(2191-2193)Gaa>Aaa	p.E731K	SYCP1_ENST00000369518.1_Missense_Mutation_p.E731K	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	731					cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAGAGACTCAGAATTAGGACT	0.313000													12	27					0	0	1	0	0
NID1	4811	broad.mit.edu	37	1	236143953	236143953	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:236143953C>T	ENST00000264187.6	-	17	3310	c.3227_splice	c.e17-1	p.G1076_splice	NID1_ENST00000366595.3_Splice_Site_p.G943_splice	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	1076					cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	AGTAAAGGTTCCTGGAGGAGG	0.428000													4	12					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	114111177	114111177	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:114111177C>T	ENST00000297405.5	-	5	969	c.725G>A	c.(724-726)gGa>gAa	p.G242E	CSMD3_ENST00000352409.3_Missense_Mutation_p.G242E|CSMD3_ENST00000519485.1_5'UTR|CSMD3_ENST00000343508.3_Missense_Mutation_p.G202E|CSMD3_ENST00000455883.2_Missense_Mutation_p.G242E	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	242	CUB 2.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CATTGTTCCTCCACAAGCATC	0.373000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			4	15					0	0	1	0	0
TBC1D22B	55633	broad.mit.edu	37	6	37247200	37247200	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:37247200G>A	ENST00000373491.3	+	3	380	c.234G>A	c.(232-234)gaG>gaA	p.E78E		NM_017772.2	NP_060242.2	Q9NU19	TB22B_HUMAN	TBC1 domain family, member 22B	78						intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|prostate(1)	15			OV - Ovarian serous cystadenocarcinoma(102;0.241)			ATGAGGAAGAGGACTTTTCCT	0.448000													23	49					0	0	1	0	0
CAPN10	11132	broad.mit.edu	37	2	241535933	241535933	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:241535933C>T	ENST00000391984.2	+	8	1672	c.1476C>T	c.(1474-1476)tcC>tcT	p.S492S	CAPN10_ENST00000270364.7_Intron|CAPN10_ENST00000404753.3_Silent_p.S492S|CAPN10_ENST00000354082.4_Intron|CAPN10_ENST00000352879.4_Intron	NM_023083.3	NP_075571.1	Q9HC96	CAN10_HUMAN	calpain 10	492	Domain III 1.				actin cytoskeleton reorganization|cellular response to insulin stimulus|positive regulation of apoptosis|positive regulation of glucose import|positive regulation of insulin secretion|positive regulation of intracellular transport|proteolysis	cytosol|plasma membrane	calcium-dependent cysteine-type endopeptidase activity|cytoskeletal protein binding|SNARE binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|urinary_tract(1)	27		all_epithelial(40;1.72e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|all_neural(83;0.0459)|Lung NSC(271;0.094)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.13e-31)|all cancers(36;3.24e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.82e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.1e-06)|Lung(119;0.00168)|Colorectal(34;0.00495)|LUSC - Lung squamous cell carcinoma(224;0.00813)|COAD - Colon adenocarcinoma(134;0.032)		GGCGAGTCTCCCTTAGGTGAG	0.632000													15	9					0	0	1	0	0
PTPRC	5788	broad.mit.edu	37	1	198678839	198678839	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:198678839G>A	ENST00000367376.2	+	11	1222	c.1051G>A	c.(1051-1053)Gaa>Aaa	p.E351K	PTPRC_ENST00000348564.6_Missense_Mutation_p.E192K|PTPRC_ENST00000594404.1_Missense_Mutation_p.E190K|PTPRC_ENST00000442510.2_Missense_Mutation_p.E353K|PTPRC_ENST00000352140.3_Missense_Mutation_p.E303K	NM_002838.4	NP_002829.3	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	351					axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(7)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(22)|lung(41)|ovary(4)|pancreas(2)|prostate(1)|skin(13)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	111						TGATAATAAAGAAATTAAATT	0.254000													11	19					0	0	1	0	0
MTHFD2L	441024	broad.mit.edu	37	4	75167500	75167500	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:75167500C>T	ENST00000395759.2	+	8	1045	c.1018C>T	c.(1018-1020)Ctg>Ttg	p.L340L	MTHFD2L_ENST00000325278.6_Silent_p.L282L	NM_001144978.1	NP_001138450.1	Q9H903	MTD2L_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like	282					folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process		binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity			central_nervous_system(1)|endometrium(1)|lung(4)|ovary(2)	8			all cancers(17;0.0101)|Lung(101;0.196)			GAACACCCTTCTGGCAGCTAA	0.378000													9	8					0	0	1	0	0
RGS2	5997	broad.mit.edu	37	1	192780138	192780138	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:192780138T>C	ENST00000235382.5	+	4	333	c.302T>C	c.(301-303)tTa>tCa	p.L101S		NM_002923.3	NP_002914.1	P41220	RGS2_HUMAN	regulator of G-protein signaling 2, 24kDa	101	Necessary to inhibit protein synthesis.|RGS.				cell cycle|negative regulation of cardiac muscle hypertrophy|negative regulation of G-protein coupled receptor protein signaling pathway|negative regulation of MAP kinase activity|negative regulation of phospholipase activity|positive regulation of cardiac muscle contraction|regulation of adrenergic receptor signaling pathway|regulation of translation|relaxation of cardiac muscle	cytosol|internal side of plasma membrane|mitochondrion|nucleolus	calmodulin binding|GTPase activator activity|signal transducer activity			large_intestine(3)|lung(1)|urinary_tract(1)	5						AGGGCTTTTTTAAAGTCGGAA	0.413000													29	38					0	0	1	0	0
TRIM71	131405	broad.mit.edu	37	3	32927434	32927434	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:32927434C>T	ENST00000383763.4	+	3	1092	c.1029C>T	c.(1027-1029)atC>atT	p.I343I		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase	343					multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AGCTGAGCATCGAGCAGGCCC	0.502000													13	28					0	0	1	0	0
SLC35C2	51006	broad.mit.edu	37	20	44984496	44984496	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:44984496G>A	ENST00000372227.1	-	5	893	c.353C>T	c.(352-354)tCc>tTc	p.S118F	SLC35C2_ENST00000543605.1_Missense_Mutation_p.S147F|SLC35C2_ENST00000317734.8_Missense_Mutation_p.S118F|SLC35C2_ENST00000372230.5_Missense_Mutation_p.S118F|SLC35C2_ENST00000372229.1_Intron|SLC35C2_ENST00000243896.2_Missense_Mutation_p.S118F			Q9NQQ7	S35C2_HUMAN	solute carrier family 35 (GDP-fucose transporter), member C2	118					transport	integral to membrane				cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	16		Myeloproliferative disorder(115;0.0122)				GACAGCTGAGGATTTGGTCAT	0.532000													31	39					0	0	1	0	0
WFDC6	140870	broad.mit.edu	37	20	44168017	44168017	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:44168017C>T	ENST00000600168.1	-	1	117	c.30G>A	c.(28-30)ctG>ctA	p.L10L	WFDC6_ENST00000372670.3_Silent_p.L10L|EPPIN-WFDC6_ENST00000504988.1_Intron|EPPIN_ENST00000555685.1_Intron					WAP four-disulfide core domain 6											breast(1)|kidney(1)|large_intestine(2)|lung(2)	6		Myeloproliferative disorder(115;0.0122)				TGAATGGTACCAGGATTGGCA	0.517000													13	25					0	0	1	0	0
TRPS1	7227	broad.mit.edu	37	8	116631937	116631937	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:116631937C>G	ENST00000395715.3	-	3	965	c.388G>C	c.(388-390)Gct>Cct	p.A130P	TRPS1_ENST00000520276.1_Missense_Mutation_p.A121P|TRPS1_ENST00000220888.5_Missense_Mutation_p.A117P|TRPS1_ENST00000519076.1_Splice_Site|TRPS1_ENST00000519674.1_Missense_Mutation_p.A117P	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	117					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CCCCCAGCAGCTGGAGATGAG	0.537000									Langer-Giedion syndrome				28	33					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43400391	43400391	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:43400391T>A	ENST00000244533.3	+	1	903	c.544T>A	c.(544-546)Tcc>Acc	p.S182T	ABCC10_ENST00000443426.2_Intron|ABCC10_ENST00000372530.4_Missense_Mutation_p.S225T	NM_033450.2	NP_258261.2	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 10	225						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GTCACGCTTTTCCTATGCCTG	0.642000													37	97					0	0	1	0	0
RHBDL2	54933	broad.mit.edu	37	1	39377005	39377005	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:39377005C>T	ENST00000289248.2	-	4	1505	c.497G>A	c.(496-498)gGa>gAa	p.G166E	RHBDL2_ENST00000372985.3_Missense_Mutation_p.G246E|RHBDL2_ENST00000372990.1_Missense_Mutation_p.G166E|RHBDL2_ENST00000538156.1_Missense_Mutation_p.G233E|RP5-864K19.4_ENST00000433671.2_RNA			Q9NX52	RHBL2_HUMAN	rhomboid, veinlet-like 2 (Drosophila)	166					proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)	8	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			TGCAATCACTCCTGCCAGGTA	0.453000													12	13					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37027208	37027208	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:37027208G>A	ENST00000358047.3	+	1	777	c.725G>A	c.(724-726)gGa>gAa	p.G242E		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	242										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						CCAGAGACTGGAGTGTCCCAT	0.632000													26	55					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233515109	233515109	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:233515109A>T	ENST00000366624.3	+	9	2618	c.2357A>T	c.(2356-2358)gAg>gTg	p.E786V	MLK4_ENST00000366622.1_Missense_Mutation_p.E232V	NM_032435.2	NP_115811.2																					ACCTGTGGGGAGGCCAGCAGC	0.592000													22	26					0	0	1	0	0
PNMA3	29944	broad.mit.edu	37	X	152225436	152225436	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:152225436C>T	ENST00000447306.1	+	2	360	c.24C>T	c.(22-24)gaC>gaT	p.D8D	PNMA3_ENST00000370264.4_Silent_p.D8D|PNMA3_ENST00000370265.4_Silent_p.D8D	NM_013364.4	NP_037496.3	Q9UL41	PNMA3_HUMAN	paraneoplastic Ma antigen 3	8					apoptosis	nucleolus	nucleic acid binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(2)	16	Acute lymphoblastic leukemia(192;6.56e-05)					tgttacaggactggtgtcggg	0.572000													25	48					0	0	1	0	0
OR10T2	128360	broad.mit.edu	37	1	158369201	158369201	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:158369201G>A	ENST00000334438.1	-	1	55	c.56C>T	c.(55-57)tCc>tTc	p.S19F		NM_001004475.1	NP_001004475.1	Q8NGX3	O10T2_HUMAN	olfactory receptor, family 10, subfamily T, member 2	19					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34	all_hematologic(112;0.0378)					CCCCAGGCTGGAGAAACCCAC	0.458000													7	11					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48285607	48285607	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:48285607C>T	ENST00000320048.1	+	1	195	c.195C>T	c.(193-195)tcC>tcT	p.S65S		NM_001004726.1	NP_001004726.1	Q8NH49	OR4X1_HUMAN	olfactory receptor, family 4, subfamily X, member 1 (gene/pseudogene)	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						GCTACTTATCCTTTGTGGAGA	0.488000													15	31					0	0	1	0	0
COL9A1	1297	broad.mit.edu	37	6	70981405	70981405	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:70981405G>A	ENST00000357250.6	-	14	1254	c.1096C>T	c.(1096-1098)Cct>Tct	p.P366S	COL9A1_ENST00000370499.4_Missense_Mutation_p.P123S|COL9A1_ENST00000320755.7_Missense_Mutation_p.P123S|COL9A1_ENST00000489611.1_5'UTR	NM_001851.4	NP_001842.3	P20849	CO9A1_HUMAN	collagen, type IX, alpha 1	366	Triple-helical region (COL3).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(44)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(4)	80						GCTGTCCCAGGAGGACCCTGA	0.368000													11	8					0	0	1	0	0
TLR6	10333	broad.mit.edu	37	4	38828713	38828713	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:38828713C>T	ENST00000436693.2	-	2	2501	c.2382G>A	c.(2380-2382)gtG>gtA	p.V794V	TLR6_ENST00000381950.1_Silent_p.V794V	NM_006068.4	NP_006059.2	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6	794					activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TTTAAGATTTCACATCATTGT	0.373000													3	8					0	0	1	0	0
UBAP2L	9898	broad.mit.edu	37	1	154207139	154207139	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:154207139G>A	ENST00000428931.1	+	5	519	c.352G>A	c.(352-354)Gag>Aag	p.E118K	UBAP2L_ENST00000343815.6_Missense_Mutation_p.E118K|UBAP2L_ENST00000361546.2_Missense_Mutation_p.E118K|UBAP2L_ENST00000271877.7_Missense_Mutation_p.E118K	NM_014847.3	NP_055662.3	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like	118					binding of sperm to zona pellucida		protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|prostate(1)|urinary_tract(2)	50	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGAATCCAATGAGGAAGGCAA	0.547000													7	11					0	0	1	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202396218	202396218	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:202396218G>A	ENST00000406302.3	+	5	905	c.752G>A	c.(751-753)tGg>tAg	p.W251*	PPP1R12B_ENST00000480184.1_Nonsense_Mutation_p.W251*|PPP1R12B_ENST00000356764.2_Nonsense_Mutation_p.W251*|PPP1R12B_ENST00000336894.4_Nonsense_Mutation_p.W251*	NM_001197131.1|NM_002481.3	NP_001184060.1|NP_002472.2	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory subunit 12B	251					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(17)|ovary(4)|skin(3)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(75;0.166)			TATGATGGCTGGACTCCCCTC	0.413000													19	35					0	0	1	0	0
PLEKHA7	144100	broad.mit.edu	37	11	16838390	16838390	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:16838390G>A	ENST00000355661.3	-	11	1833	c.1823C>T	c.(1822-1824)tCg>tTg	p.S608L	PLEKHA7_ENST00000532079.1_Intron|PLEKHA7_ENST00000531066.1_Missense_Mutation_p.S608L|PLEKHA7_ENST00000448080.2_Missense_Mutation_p.S608L			Q6IQ23	PKHA7_HUMAN	pleckstrin homology domain containing, family A member 7	608	Interaction with CTNND1.				epithelial cell-cell adhesion|zonula adherens maintenance	centrosome|zonula adherens	delta-catenin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	37						ATCCCCCAGCGAGATGTCCAC	0.662000													22	32					0	0	1	0	0
NDUFV1	4723	broad.mit.edu	37	11	67378902	67378902	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:67378902C>T	ENST00000322776.6	+	7	1095	c.942C>T	c.(940-942)ctC>ctT	p.L314L	NDUFV1_ENST00000415352.2_Silent_p.L307L|NDUFV1_ENST00000529927.1_Silent_p.L305L|NDUFV1_ENST00000532303.1_Silent_p.L213L|NDUFV1_ENST00000526169.1_Intron	NM_001166102.1|NM_007103.3	NP_001159574.1|NP_009034.2	P49821	NDUV1_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa	314					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|FMN binding|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			breast(1)|endometrium(3)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	16					NADH(DB00157)	GGGACAACCTCCTTGCTGTGA	0.647000													14	17					0	0	1	0	0
TRAV12-1	28674	broad.mit.edu	37	14	22309670	22309670	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:22309670G>A	ENST00000390433.1	+	0	54																											TTTTCACAGGGGTTTGGAGCC	0.468000													7	22					0	0	1	0	0
DGKK	139189	broad.mit.edu	37	X	50121158	50121158	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:50121158G>A	ENST00000376025.2	-	0	3108							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					CCTGGTCTCTGAATCCAGGCC	0.488000													6	16					0	0	1	0	0
OR5AR1	219493	broad.mit.edu	37	11	56432089	56432089	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:56432089C>T	ENST00000302969.2	+	1	952	c.928C>T	c.(928-930)Caa>Taa	p.Q310*		NM_001004730.1	NP_001004730.1	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR, member 1 (gene/pseudogene)	310					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(12)|prostate(1)|skin(3)|stomach(1)	26						AAAAAAATCTCAATAATAACA	0.348000													6	9					0	0	1	0	0
PRKX	5613	broad.mit.edu	37	X	3592716	3592716	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:3592716G>A	ENST00000262848.5	-	2	612	c.258C>T	c.(256-258)atC>atT	p.I86I		NM_005044.4	NP_005035.1	P51817	PRKX_HUMAN	protein kinase, X-linked	86	Protein kinase.						ATP binding|cAMP-dependent protein kinase activity			kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|skin(2)	12		all_lung(23;0.000396)|Lung NSC(23;0.00123)				GCTTTAGGCGGATGACGTCGG	0.567000													25	42					0	0	1	0	0
GORAB	92344	broad.mit.edu	37	1	170521559	170521559	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:170521559C>T	ENST00000367763.3	+	5	1161	c.1141C>T	c.(1141-1143)Cca>Tca	p.P381S		NM_152281.2	NP_689494.2	Q5T7V8	GORAB_HUMAN	golgin, RAB6-interacting	381	Necessary for interaction with RCHY1.					Golgi apparatus|nucleus				endometrium(2)|large_intestine(3)|liver(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	17						TCCAAACTGCCCAAATCAAGA	0.398000													30	56					0	0	1	0	0
NIPAL3	57185	broad.mit.edu	37	1	24795649	24795649	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:24795649G>C	ENST00000003912.3	+	13	1664	c.949G>C	c.(949-951)Gtc>Ctc	p.V317L	NIPAL3_ENST00000374399.4_Missense_Mutation_p.V399L			Q6P499	NPAL3_HUMAN	NIPA-like domain containing 3	399						integral to membrane				endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|skin(1)	14						CCCCTACCGAGTCCTAGAGCA	0.522000													9	14					0	0	1	0	0
FGF9	2254	broad.mit.edu	37	13	22255241	22255241	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:22255241G>A	ENST00000382353.5	+	2	868	c.338G>A	c.(337-339)gGa>gAa	p.G113E		NM_002010.2	NP_002001.1	P31371	FGF9_HUMAN	fibroblast growth factor 9	113					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|male gonad development|positive regulation of cell division	extracellular space	growth factor activity|heparin binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|skin(2)	9		all_cancers(29;1.23e-20)|all_epithelial(30;9.83e-19)|all_lung(29;9.64e-17)|Lung SC(185;0.0262)|Breast(139;0.106)		all cancers(112;3.92e-05)|Epithelial(112;0.000166)|OV - Ovarian serous cystadenocarcinoma(117;0.00314)|Lung(94;0.163)		GTGGACAGTGGACTCTACCTC	0.483000													39	36					0	0	1	0	0
ZNF229	7772	broad.mit.edu	37	19	44934628	44934628	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:44934628C>T	ENST00000291187.4	-	6	632	c.310G>A	c.(310-312)Gaa>Aaa	p.E104K	ZNF229_ENST00000588931.1_Missense_Mutation_p.E110K|CTC-512J12.4_ENST00000588655.1_RNA|ZNF229_ENST00000591289.1_Intron	NM_001278510.1	NP_001265439.1	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	110	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(2)|endometrium(6)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	45		Prostate(69;0.0352)				GCCACCTCTTCCCAGATTTTG	0.438000													17	22					0	0	1	0	0
TMEM54	113452	broad.mit.edu	37	1	33360931	33360931	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:33360931C>T	ENST00000373463.3	-	5	688	c.569G>A	c.(568-570)tGg>tAg	p.W190*	TMEM54_ENST00000475208.1_5'UTR|TMEM54_ENST00000329151.5_Nonsense_Mutation_p.W137*	NM_033504.2	NP_277039.1	Q969K7	TMM54_HUMAN	transmembrane protein 54	190						integral to membrane				endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|urinary_tract(1)	6		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				TTTCCCCCACCAGGGCCTCAG	0.642000													5	12					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	75684294	75684294	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:75684294G>A	ENST00000370855.5	-	17	1523	c.1410C>T	c.(1408-1410)ttC>ttT	p.F470F	SLC44A5_ENST00000535611.1_Silent_p.F340F|SLC44A5_ENST00000370859.3_Silent_p.F470F	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	470						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						ATGCAATGACGAAGTTTATAA	0.418000													28	47					0	0	1	0	0
MYBPC2	4606	broad.mit.edu	37	19	50958438	50958438	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:50958438C>T	ENST00000357701.5	+	19	2139	c.2088C>T	c.(2086-2088)acC>acT	p.T696T		NM_004533.3	NP_004524.3	Q14324	MYPC2_HUMAN	myosin binding protein C, fast type	696	Fibronectin type-III 1.				cell adhesion|muscle filament sliding	cytosol|myosin filament	actin binding|structural constituent of muscle			breast(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.0079)|GBM - Glioblastoma multiforme(134;0.0144)		TCACAGAGACCACCTATGAGT	0.547000													17	24					0	0	1	0	0
RALGPS1	9649	broad.mit.edu	37	9	129831519	129831519	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:129831519G>A	ENST00000259351.5	+	8	761	c.494G>A	c.(493-495)cGa>cAa	p.R165Q	RALGPS1_ENST00000373436.1_Missense_Mutation_p.R165Q|RALGPS1_ENST00000424082.2_Missense_Mutation_p.R165Q|RALGPS1_ENST00000394022.3_Missense_Mutation_p.R165Q|RALGPS1_ENST00000373434.1_Missense_Mutation_p.R165Q	NM_014636.2	NP_055451.1	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	165	Ras-GEF.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			kidney(2)|large_intestine(6)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	19						CTTTTAAATCGAAAAGACAAG	0.368000													10	9					0	0	1	0	0
GAGE2A	729447	broad.mit.edu	37	X	49355893	49355893	+	Missense_Mutation	SNP	C	C	G	rs147803166	by1000genomes	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:49355893C>G	ENST00000362097.1	+	3	258	c.175C>G	c.(175-177)Cag>Gag	p.Q59E		NM_001127212.1	NP_001120684.1			G antigen 2A									p.Q59E(8)		endometrium(4)	4	Ovarian(276;0.236)					TCAGGAGGGACAGGATGAGGG	0.562000													6	655					0	0	1	0	0
NOX4	50507	broad.mit.edu	37	11	89224397	89224397	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:89224397C>T	ENST00000263317.4	-	1	256	c.18G>A	c.(16-18)agG>agA	p.R6R	NOX4_ENST00000532825.1_Intron|NOX4_ENST00000424319.1_Intron|NOX4_ENST00000375979.3_Silent_p.R6R|NOX4_ENST00000527626.1_5'UTR|NOX4_ENST00000531342.1_Silent_p.R6R|NOX4_ENST00000527956.1_Intron|NOX4_ENST00000525196.1_Silent_p.R6R|NOX4_ENST00000534731.1_Silent_p.R6R|NOX4_ENST00000535633.1_5'UTR|NOX4_ENST00000542487.1_Intron|NOX4_ENST00000393282.2_Silent_p.R6R			Q9NPH5	NOX4_HUMAN	NADPH oxidase 4	6					cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(8)|lung(20)|ovary(2)|prostate(3)|skin(2)	44		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				CGAGCCAGCTCCTCCAGGACA	0.652000													13	13					0	0	1	0	0
SEC31A	22872	broad.mit.edu	37	4	83793119	83793119	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:83793119G>A	ENST00000432794.1	-	7	923	c.760C>T	c.(760-762)Cgt>Tgt	p.R254C	SEC31A_ENST00000508479.1_Missense_Mutation_p.R254C|SEC31A_ENST00000513858.1_Missense_Mutation_p.R254C|SEC31A_ENST00000436790.2_5'UTR|SEC31A_ENST00000509142.1_Missense_Mutation_p.R254C|SEC31A_ENST00000508502.1_Missense_Mutation_p.R254C|SEC31A_ENST00000505984.1_Missense_Mutation_p.R254C|SEC31A_ENST00000505472.1_Missense_Mutation_p.R254C|SEC31A_ENST00000500777.2_Missense_Mutation_p.R254C|SEC31A_ENST00000448323.1_Missense_Mutation_p.R254C|SEC31A_ENST00000443462.2_Missense_Mutation_p.R249C|SEC31A_ENST00000395310.2_Missense_Mutation_p.R254C|SEC31A_ENST00000355196.2_Missense_Mutation_p.R254C|SEC31A_ENST00000348405.4_Missense_Mutation_p.R254C|SEC31A_ENST00000326950.5_Missense_Mutation_p.R254C|SEC31A_ENST00000311785.7_Missense_Mutation_p.R254C			O94979	SC31A_HUMAN	SEC31 homolog A (S. cerevisiae)	254	Interaction with SEC13.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/ALK(3)|SEC31A/JAK2(4)	breast(1)	1		Hepatocellular(203;0.114)				TCCAGGACACGAAGTGGAGAG	0.463000													6	17					0	0	1	0	0
SMAD3	4088	broad.mit.edu	37	15	67457672	67457672	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:67457672C>T	ENST00000327367.4	+	3	792	c.482C>T	c.(481-483)cCc>cTc	p.P161L	SMAD3_ENST00000540846.2_Missense_Mutation_p.P56L|SMAD3_ENST00000439724.3_Missense_Mutation_p.P117L	NM_005902.3	NP_005893.1	P84022	SMAD3_HUMAN	SMAD family member 3	161	Linker.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(11)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		CATTCCATCCCCGAAAACACT	0.632000													50	106					0	0	1	0	0
CYTH4	27128	broad.mit.edu	37	22	37695268	37695268	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:37695268G>A	ENST00000248901.6	+	6	542	c.353_splice	c.e6-1	p.D119_splice	CYTH4_ENST00000405206.3_Splice_Site_p.D119_splice|CYTH4_ENST00000402997.1_Splice_Site_p.D119_splice|CYTH4_ENST00000439667.1_3'UTR	NM_013385.3	NP_037517.1	Q9UIA0	CYH4_HUMAN	cytohesin 4	119	SEC7.				regulation of ARF protein signal transduction|regulation of cell adhesion	cytoplasm|plasma membrane	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(7)|ovary(2)|stomach(1)	15						CTCCCCCAGGGATCCCATCAA	0.647000													5	51					0	0	1	0	0
ARHGEF6	9459	broad.mit.edu	37	X	135764997	135764997	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:135764997C>T	ENST00000250617.6	-	13	2604	c.1399G>A	c.(1399-1401)Gag>Aag	p.E467K	ARHGEF6_ENST00000535227.1_Missense_Mutation_p.E340K|ARHGEF6_ENST00000370622.1_Missense_Mutation_p.E313K|ARHGEF6_ENST00000370620.1_Missense_Mutation_p.E313K	NM_004840.2	NP_004831.1	Q15052	ARHG6_HUMAN	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6	467	PH.				apoptosis|cell junction assembly|induction of apoptosis by extracellular signals|JNK cascade|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|liver(1)|lung(14)|prostate(1)	38	Acute lymphoblastic leukemia(192;0.000127)					TACCGCTCCTCTTTTTCCTGA	0.343000													7	19					0	0	1	0	0
FBXO40	51725	broad.mit.edu	37	3	121340811	121340811	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:121340811G>A	ENST00000338040.4	+	3	949	c.535G>A	c.(535-537)Ggt>Agt	p.G179S		NM_016298.3	NP_057382.2	Q9UH90	FBX40_HUMAN	F-box protein 40	179					muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(11)|lung(19)|ovary(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	46				GBM - Glioblastoma multiforme(114;0.189)		AGTGGATATCGGTTTGGTACC	0.498000													10	13					0	0	1	0	0
SLC46A3	283537	broad.mit.edu	37	13	29284912	29284912	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:29284912G>A	ENST00000266943.6	-	4	1498	c.1129C>T	c.(1129-1131)Cgt>Tgt	p.R377C	SLC46A3_ENST00000380814.4_Missense_Mutation_p.R377C	NM_001135919.1|NM_181785.3	NP_001129391.1|NP_861450.1	Q7Z3Q1	S46A3_HUMAN	solute carrier family 46, member 3	377					transmembrane transport	integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|skin(1)	15		Lung SC(185;0.0367)		all cancers(112;0.159)		TCAGTCGAACGAACCACTTTT	0.388000													41	34					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	117075099	117075099	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:117075099C>T	ENST00000355044.3	+	18	3016	c.2890C>T	c.(2890-2892)Cct>Tct	p.P964S	ATRNL1_ENST00000423111.2_Missense_Mutation_p.P61S|ATRNL1_ENST00000303745.7_5'UTR	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	964	PSI 5.					integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GTGCAATGATCCTAGTAATAC	0.448000													11	11					0	0	1	0	0
CNTNAP3	79937	broad.mit.edu	37	9	39171455	39171455	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:39171455C>T	ENST00000297668.6	-	8	1317	c.1244G>A	c.(1243-1245)gGt>gAt	p.G415D	CNTNAP3_ENST00000377659.1_Missense_Mutation_p.G415D|CNTNAP3_ENST00000323947.7_Missense_Mutation_p.G415D|CNTNAP3_ENST00000358144.2_Missense_Mutation_p.G327D|CNTNAP3_ENST00000377656.2_Missense_Mutation_p.G415D	NM_033655.3	NP_387504.2	Q9BZ76	CNTP3_HUMAN	contactin associated protein-like 3	415	Laminin G-like 2.				cell adhesion|cell recognition|signal transduction	extracellular region|integral to membrane|plasma membrane	receptor binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	24				GBM - Glioblastoma multiforme(29;0.02)|Lung(182;0.0681)		ACTCCCTGAACCACGTCGAAG	0.502000													24	36					0	0	1	0	0
PDC	5132	broad.mit.edu	37	1	186413501	186413501	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:186413501C>T	ENST00000391997.2	-	4	438	c.351G>A	c.(349-351)ctG>ctA	p.L117L	PDC_ENST00000497198.1_Silent_p.L65L|PDC_ENST00000456239.2_Silent_p.L65L|PDC_ENST00000340129.5_Silent_p.L117L	NM_002597.4	NP_002588.3	P20941	PHOS_HUMAN	phosducin	117					G-protein coupled receptor protein signaling pathway|phototransduction|visual perception	actin cytoskeleton|cytosol|nucleus|photoreceptor inner segment|photoreceptor outer segment	phospholipase inhibitor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|prostate(1)|skin(1)	7		Breast(1374;1.53e-05)		KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.0129)		TTCCAGTTTCCAGCTCATACA	0.403000													30	58					0	0	1	0	0
ACOT12	134526	broad.mit.edu	37	5	80628317	80628317	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:80628317C>T	ENST00000307624.3	-	13	1398	c.1370G>A	c.(1369-1371)cGa>cAa	p.R457Q	ACOT12_ENST00000508234.1_5'UTR	NM_130767.2	NP_570123.1	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	457	START.				acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)	23		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		GGGTTTTCTTCGTGATACGAG	0.368000													10	15					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141797438	141797438	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:141797438G>A	ENST00000475668.2	+	66	7792	c.7738G>A	c.(7738-7740)Gat>Aat	p.D2580N	MGAM_ENST00000549489.2_Missense_Mutation_p.D1684N			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1684					polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CCGCTGGTATGATTACTACAC	0.413000													7	18					0	0	1	0	0
C8orf22	492307	broad.mit.edu	37	8	49986633	49986633	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:49986633C>T	ENST00000303202.8	+	3	244	c.71C>T	c.(70-72)tCa>tTa	p.S24L	C8orf22_ENST00000522267.1_Missense_Mutation_p.S24L|C8orf22_ENST00000399653.4_Missense_Mutation_p.S24L|C8orf22_ENST00000517663.1_Missense_Mutation_p.S24L	NM_001256598.1	NP_001243527.1	Q8WWR9	PDPFL_HUMAN	chromosome 8 open reading frame 22	24										large_intestine(1)|lung(7)|prostate(1)	9		all_cancers(86;0.0452)|all_epithelial(80;0.000863)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				AGTGTTTCTTCAGTTAGTTCT	0.333000													10	20					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117609807	117609807	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:117609807C>T	ENST00000368508.3	-	43	7090	c.6892G>A	c.(6892-6894)Gaa>Aaa	p.E2298K	ROS1_ENST00000368507.3_Missense_Mutation_p.E2292K	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	2298					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		CCACAAGATTCAGATTCCTGG	0.468000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								18	9					0	0	1	0	0
OR1L3	26735	broad.mit.edu	37	9	125437901	125437901	+	Missense_Mutation	SNP	C	C	T	rs142794411	byFrequency	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:125437901C>T	ENST00000304820.2	+	1	587	c.493C>T	c.(493-495)Cgg>Tgg	p.R165W		NM_001005234.1	NP_001005234.1	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L, member 3	165					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	16						CCTGGTGAATCGGCTCACCTT	0.428000													54	27					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	147733596	147733596	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:147733596G>A	ENST00000370460.2	+	2	603	c.124G>A	c.(124-126)Gat>Aat	p.D42N	AFF2_ENST00000370457.5_Missense_Mutation_p.D42N|AFF2_ENST00000342251.3_Missense_Mutation_p.D42N|AFF2_ENST00000370458.1_Missense_Mutation_p.D42N	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	42					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					GCAAGAAGACGATCTCTTTTC	0.378000													42	46					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2815273	2815273	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:2815273C>T	ENST00000520002.1	-	64	10317	c.9762G>A	c.(9760-9762)acG>acA	p.T3254T	CSMD1_ENST00000542608.1_Silent_p.T3076T|CSMD1_ENST00000537824.1_Silent_p.T3253T|CSMD1_ENST00000602723.1_Silent_p.T3077T|CSMD1_ENST00000400186.3_Silent_p.T3077T|CSMD1_ENST00000602557.1_Silent_p.T3254T			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3254	Sushi 27.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		AGGTGCGAGTCGTGGAACCTT	0.443000													3	2					0	0	1	0	0
SGTB	54557	broad.mit.edu	37	5	64976485	64976485	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:64976485G>A	ENST00000381007.4	-	7	851	c.616C>T	c.(616-618)Cct>Tct	p.P206S		NM_019072.2	NP_061945.1	Q96EQ0	SGTB_HUMAN	small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta	206							binding			large_intestine(3)|lung(3)|skin(3)	9		Lung NSC(167;3.24e-06)|Prostate(74;0.0138)|Ovarian(174;0.0545)|Breast(144;0.174)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0657)|Lung(70;0.00487)		CAACTTACAGGACTGGATACC	0.318000													24	49					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105414309	105414309	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:105414309G>A	ENST00000333244.5	-	7	7598	c.7479C>T	c.(7477-7479)ttC>ttT	p.F2493F	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2493						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CAGACACCCCGAATGACGGCA	0.607000													113	183					0	0	1	0	0
ALB	213	broad.mit.edu	37	4	74270882	74270882	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:74270882C>T	ENST00000295897.4	+	2	218	c.129C>T	c.(127-129)ttC>ttT	p.F43F	ALB_ENST00000415165.2_Silent_p.F43F|ALB_ENST00000503124.1_Intron|ALB_ENST00000401494.3_Silent_p.F43F|ALB_ENST00000509063.1_Silent_p.F43F	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	43	Albumin 1.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	AAGAAAATTTCAAAGCCTTGT	0.308000													13	15					0	0	1	0	0
OR2A14	135941	broad.mit.edu	37	7	143827039	143827039	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:143827039C>T	ENST00000408899.2	+	1	889	c.834C>T	c.(832-834)agC>agT	p.S278S		NM_001001659.1	NP_001001659.1	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A, member 14	278					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(17)|skin(1)	22	Melanoma(164;0.0783)					TGTTTTACAGCCTTTTCAATC	0.552000													49	83					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63489473	63489473	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:63489473G>A	ENST00000536984.2	+	5	1476	c.782G>A	c.(781-783)cGc>cAc	p.R261H	CDH7_ENST00000323011.3_Missense_Mutation_p.R261H|CDH7_ENST00000397968.2_Missense_Mutation_p.R261H			Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	261	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R261H(2)		NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				AATCCACCTCGCTTTCCTCGA	0.373000													16	14					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993296	140993296	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:140993296C>A	ENST00000285879.4	+	4	392	c.106C>A	c.(106-108)Cag>Aag	p.Q36K	MAGEC1_ENST00000406005.2_5'UTR	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	36							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					GTCTCCTCTCCAGATTCCCCA	0.577000										HNSCC(15;0.026)			33	63					8.4185e-14	8.55012e-14	1	1	0
OR8A1	390275	broad.mit.edu	37	11	124440111	124440111	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:124440111C>T	ENST00000284287.3	+	1	219	c.147C>T	c.(145-147)ctC>ctT	p.L49L		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	49					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		TCCTCTTCCTCGGGATCTACT	0.502000													20	31					0	0	1	0	0
IGHV5-51	28388	broad.mit.edu	37	14	107034838	107034838	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:107034838G>A	ENST00000390626.2	-	0	300																											TTGGAAGGACGGGCTGTATCT	0.587000													21	48					0	0	1	0	0
HSD11B1	3290	broad.mit.edu	37	1	209907730	209907730	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:209907730G>A	ENST00000367028.2	+	7	912	c.743G>A	c.(742-744)gGg>gAg	p.G248E	HSD11B1_ENST00000367027.3_Missense_Mutation_p.G248E|HSD11B1_ENST00000261465.1_Missense_Mutation_p.G248E	NM_001206741.1	NP_001193670.1	P28845	DHI1_HUMAN	hydroxysteroid (11-beta) dehydrogenase 1	248					glucocorticoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	11-beta-hydroxysteroid dehydrogenase|11-beta-hydroxysteroid dehydrogenase (NADP+) activity|binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	16				OV - Ovarian serous cystadenocarcinoma(81;1.04e-55)|Epithelial(68;1.57e-52)|all cancers(67;1.83e-46)|Colorectal(1306;0.115)	NADH(DB00157)	ATCATCAAAGGGGGAGCTCTG	0.468000													21	17					0	0	1	0	0
ECT2L	345930	broad.mit.edu	37	6	139222235	139222235	+	Silent	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:139222235A>T	ENST00000423192.1	+	20	2726	c.2565A>T	c.(2563-2565)atA>atT	p.I855I	ECT2L_ENST00000367682.2_Silent_p.I855I|ECT2L_ENST00000541398.1_Silent_p.I709I			Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2 oncogene-like	855					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(1)	30						GGTTACTCATAGAAAATATTC	0.393000			"""N, Splice, Mis"""		ETP ALL								12	14					0	0	1	0	0
MCM7	4176	broad.mit.edu	37	7	99696780	99696780	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:99696780G>A	ENST00000303887.5	-	5	1093	c.448C>T	c.(448-450)Cgg>Tgg	p.R150W	MCM7_ENST00000343023.6_Missense_Mutation_p.R150W|MCM7_ENST00000354230.3_5'UTR	NM_005916.3	NP_005907.3	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	150					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding			endometrium(1)|kidney(5)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	17	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	CGCACTTCCCGGATCACACGA	0.512000													16	30					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56330219	56330219	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:56330219C>T	ENST00000288221.6	-	3	1157	c.902G>A	c.(901-903)cGa>cAa	p.R301Q		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	301						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TGACTCATCTCGGGCATTGAG	0.478000													60	119					0	0	1	0	0
SCAMP3	10067	broad.mit.edu	37	1	155230365	155230365	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:155230365G>A	ENST00000355379.3	-	2	430	c.152C>T	c.(151-153)cCc>cTc	p.P51L	SCAMP3_ENST00000302631.3_Missense_Mutation_p.P77L	NM_052837.2	NP_443069.1	O14828	SCAM3_HUMAN	secretory carrier membrane protein 3	77					post-Golgi vesicle-mediated transport|protein transport	integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(7)|ovary(4)|urinary_tract(1)	19	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			AGGTTCTGTGGGGCTGAGCTT	0.607000													19	53					0	0	1	0	0
GPC4	2239	broad.mit.edu	37	X	132438840	132438840	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:132438840G>A	ENST00000370828.3	-	7	1729	c.1205C>T	c.(1204-1206)tCc>tTc	p.S402F	GPC4_ENST00000535467.1_Missense_Mutation_p.S332F	NM_001448.2	NP_001439.2	O75487	GPC4_HUMAN	glypican 4	402					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;0.000127)					GCTCGGAAGGGAGGACCAGAA	0.423000													34	46					0	0	1	0	0
APBB1IP	54518	broad.mit.edu	37	10	26792132	26792132	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:26792132G>A	ENST00000376236.4	+	6	915	c.460G>A	c.(460-462)Gaa>Aaa	p.E154K		NM_019043.3	NP_061916.3	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein	154	Poly-Glu.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(27)|skin(7)|upper_aerodigestive_tract(1)	45						CCAGGAAGAGGAAGAAGCCCA	0.433000													13	4					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76903203	76903203	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:76903203C>T	ENST00000409709.3	+	31	4304	c.4032C>T	c.(4030-4032)ctC>ctT	p.L1344L	MYO7A_ENST00000458637.2_Silent_p.L1344L|MYO7A_ENST00000409619.2_Silent_p.L1333L	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1344	FERM 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						CCTGGAGGCTCTTCTTCCGCA	0.647000											OREG0021258	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	32					0	0	1	0	0
IGSF10	285313	broad.mit.edu	37	3	151164525	151164525	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:151164525G>A	ENST00000282466.3	-	4	3243	c.3244C>T	c.(3244-3246)Cca>Tca	p.P1082S		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1082					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCAGCACTTGGAAAAGACAAT	0.483000													26	67					0	0	1	0	0
ABCA10	10349	broad.mit.edu	37	17	67210939	67210939	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:67210939C>T	ENST00000269081.4	-	10	1821	c.912G>A	c.(910-912)ggG>ggA	p.G304G	ABCA10_ENST00000432313.2_Silent_p.G304G|ABCA10_ENST00000416101.2_Silent_p.G304G	NM_080282.3	NP_525021.3	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 10	304					transport	integral to membrane	ATP binding|ATPase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(34)|ovary(2)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	81	Breast(10;6.95e-12)					TGTATGAATCCCCAGAGGGAT	0.294000													18	27					0	0	1	0	0
CREBRF	153222	broad.mit.edu	37	5	172550206	172550206	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:172550206G>A	ENST00000540014.1	+	9	2129		c.e9+1		CREBRF_ENST00000296953.2_Splice_Site			Q8IUR6	CE041_HUMAN	CREB3 regulatory factor								protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity										GATACTCTCGGTAAGAAGAAT	0.348000													12	33					0	0	1	0	0
RP11-876N24.2	0	broad.mit.edu	37	16	10960174	10960174	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:10960174C>T	ENST00000572017.1	-	0	438																											CATCCTGACTCAGGTGAGAAT	0.607000													4	16					0	0	1	0	0
LY75	4065	broad.mit.edu	37	2	160738736	160738736	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:160738736C>T	ENST00000263636.4	-	7	1172	c.1145G>A	c.(1144-1146)tGg>tAg	p.W382*	LY75_ENST00000553424.1_Nonsense_Mutation_p.W382*|LY75-CD302_ENST00000505052.1_Nonsense_Mutation_p.W382*|LY75-CD302_ENST00000504764.1_Nonsense_Mutation_p.W382*|LY75_ENST00000554112.1_Nonsense_Mutation_p.W382*	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		TGCCTTATCCCAGGAATTACT	0.448000													29	15					0	0	1	0	0
MST1L	11223	broad.mit.edu	37	1	17084250	17084250	+	RNA	SNP	T	T	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:17084250T>A	ENST00000455405.2	-	0	558																											TGCTCTTACCTTTGGTCTCAC	0.602000													28	256					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103123406	103123406	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:103123406C>T	ENST00000428762.1	-	63	10353	c.10194G>A	c.(10192-10194)atG>atA	p.M3398I	RELN_ENST00000343529.5_Missense_Mutation_p.M3398I|RELN_ENST00000473945.1_5'UTR|RELN_ENST00000424685.2_Missense_Mutation_p.M3398I|CTB-107G13.1_ENST00000422488.1_RNA	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	3398					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		AGACTCCTTTCATCCGTGCCT	0.433000													11	25					0	0	1	0	0
RGS7BP	401190	broad.mit.edu	37	5	63890537	63890537	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:63890537G>A	ENST00000334025.2	+	4	790	c.463_splice	c.e4-1	p.G155_splice		NM_001029875.1|NM_001271890.1|NM_001271891.1	NP_001025046.1|NP_001258819.1|NP_001258820.1	Q6MZT1	R7BP_HUMAN	regulator of G-protein signaling 7 binding protein	155					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane				breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|stomach(1)	11		Lung NSC(810;0.000518)|Prostate(74;0.0435)|Ovarian(174;0.186)		Lung(70;0.147)		CCTCCCTTAGGAAAGGAACCT	0.473000													46	8					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236456	140236456	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140236456G>A	ENST00000307360.5	+	1	823	c.823G>A	c.(823-825)Gaa>Aaa	p.E275K	PCDHA9_ENST00000532602.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA10_ENST00000506939.2_Missense_Mutation_p.E275K|PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATAAACAAGGAAATGATGTA	0.363000													14	38					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120471786	120471786	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:120471786G>A	ENST00000256646.2	-	23	3924	c.3705C>T	c.(3703-3705)tgC>tgT	p.C1235C		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	1235	EGF-like 32; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CACCATTAAGGCAATGGGGAC	0.507000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				10	15					0	0	1	0	0
PRSS8	5652	broad.mit.edu	37	16	31143657	31143657	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:31143657C>T	ENST00000317508.6	-	6	969		c.e6-1		PRSS8_ENST00000568261.1_Splice_Site	NM_002773.3	NP_002764.1	Q16651	PRSS8_HUMAN	protease, serine, 8						proteolysis	extracellular space|integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|skin(1)|upper_aerodigestive_tract(1)	8						CAGAGTCACCCTGAGGAGAGA	0.657000													8	19					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23716293	23716293	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:23716293G>A	ENST00000256797.4	-	8	1077	c.909C>T	c.(907-909)ttC>ttT	p.F303F	ERN2_ENST00000457008.2_Silent_p.F255F	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	255					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		GGAGGGCGAGGAAATGCAGAG	0.662000													20	37					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140554308	140554308	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140554308G>A	ENST00000231137.3	+	1	2066	c.1892G>A	c.(1891-1893)aGc>aAc	p.S631N		NM_018940.2	NP_061763.1	Q9Y5E2	PCDB7_HUMAN		631	Cadherin 6.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGGCTGCTGAGCGAGCGCGAC	0.687000													31	151					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41539195	41539195	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr21:41539195C>T	ENST00000400454.1	-	16	3445	c.2968G>A	c.(2968-2970)Gaa>Aaa	p.E990K		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	990	Fibronectin type-III 2.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AGGTGAACTTCCTGAGGTGGA	0.532000													22	10					0	0	1	0	0
B4GALNT4	338707	broad.mit.edu	37	11	373193	373193	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:373193G>A	ENST00000329962.6	+	6	538	c.538G>A	c.(538-540)Gac>Aac	p.D180N		NM_178537.4	NP_848632.2	Q76KP1	B4GN4_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 4	180						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			endometrium(2)|kidney(4)|large_intestine(1)|liver(2)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGGACTAGGAGACGTCCAGTT	0.642000													10	18					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118362005	118362005	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:118362005C>T	ENST00000534358.1	+	14	4814	c.4791C>T	c.(4789-4791)tcC>tcT	p.S1597S	KMT2A_ENST00000389506.5_Silent_p.S1597S|KMT2A_ENST00000354520.4_Silent_p.S1559S	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		GGGTCCATTCCAAATGTGAGA	0.378000													23	46					0	0	1	0	0
MAGED1	9500	broad.mit.edu	37	X	51641707	51641707	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:51641707G>A	ENST00000375695.2	+	11	2133	c.1980G>A	c.(1978-1980)agG>agA	p.R660R	MAGED1_ENST00000494718.1_3'UTR|MAGED1_ENST00000326587.7_Silent_p.R604R|MAGED1_ENST00000375722.1_Silent_p.R604R|MAGED1_ENST00000375772.3_Silent_p.R604R	NM_001005333.1	NP_001005333.1	Q9Y5V3	MAGD1_HUMAN	melanoma antigen family D, 1	604	MAGE.				apoptosis|induction of apoptosis by extracellular signals|negative regulation of epithelial cell proliferation|nerve growth factor receptor signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|plasma membrane|protein complex	protein binding			breast(1)|endometrium(4)|large_intestine(10)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	32	Ovarian(276;0.236)					GAGATCTAAGGAAACTTCTCA	0.448000										Multiple Myeloma(10;0.10)			6	10					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55583112	55583112	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:55583112G>A	ENST00000361849.3	-	34	4774	c.4380C>T	c.(4378-4380)ttC>ttT	p.F1460F	PCDH15_ENST00000395432.2_Silent_p.F1418F|PCDH15_ENST00000395433.1_Silent_p.F1435F|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000409834.1_Intron|PCDH15_ENST00000320301.6_Silent_p.F1458F|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000373957.3_Intron|PCDH15_ENST00000395438.1_Intron|PCDH15_ENST00000395430.1_Silent_p.F1455F|PCDH15_ENST00000395442.1_Intron|PCDH15_ENST00000463095.1_5'UTR|PCDH15_ENST00000395445.1_Intron|PCDH15_ENST00000437009.1_Silent_p.F1389F|PCDH15_ENST00000395446.1_Intron	NM_001142763.1|NM_001142764.1|NM_001142765.1|NM_001142768.1	NP_001136235.1|NP_001136236.1|NP_001136237.1|NP_001136240.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	1458					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GGTAGAGAAGGAAAAGACTTG	0.348000										HNSCC(58;0.16)			10	3					0	0	1	0	0
RAVER1	125950	broad.mit.edu	37	19	10439630	10439630	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:10439630G>A	ENST00000293677.6	-	3	576	c.495C>T	c.(493-495)ttC>ttT	p.F165F		NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	148	RRM 2.					cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			CCAGCTCCTCGAACTGCTGCT	0.642000													7	10					0	0	1	0	0
KY	339855	broad.mit.edu	37	3	134322946	134322946	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:134322946C>T	ENST00000508956.1	-	10	1455	c.1398G>A	c.(1396-1398)gaG>gaA	p.E466E	KY_ENST00000503669.1_3'UTR|KY_ENST00000423778.2_Silent_p.E487E			Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	487						cytoskeleton|Z disc	peptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|lung(12)|ovary(2)|upper_aerodigestive_tract(2)	21						TAATGCCCTCCTCCACGCTGA	0.612000													4	10					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70988446	70988446	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:70988446G>A	ENST00000334414.6	-	6	1361	c.1317C>T	c.(1315-1317)tcC>tcT	p.S439S	PTPRB_ENST00000550358.1_Silent_p.S439S|PTPRB_ENST00000538708.1_Silent_p.S221S|PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000451516.2_Silent_p.S221S|PTPRB_ENST00000550857.1_Silent_p.S221S|PTPRB_ENST00000551525.1_Silent_p.S438S|PTPRB_ENST00000261266.5_Silent_p.S221S	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	221	Fibronectin type-III 5.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CATGGGACCAGGAAATCAGGA	0.433000													18	19					0	0	1	0	0
SPANXN3	139067	broad.mit.edu	37	X	142596840	142596840	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:142596840G>A	ENST00000370503.2	-	2	313	c.230C>T	c.(229-231)tCc>tTc	p.S77F	GS1-256O22.5_ENST00000431432.1_RNA	NM_001009609.2	NP_001009609.1	Q5MJ09	SPXN3_HUMAN	SPANX family, member N3	77								p.S77F(1)		endometrium(1)|large_intestine(1)|lung(9)|ovary(2)|urinary_tract(1)	14	Acute lymphoblastic leukemia(192;6.56e-05)					TGGATTGATGGAGTTCTCTTG	0.393000													30	55					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144886128	144886128	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:144886128C>T	ENST00000369359.4	-	26	3555	c.3517G>A	c.(3517-3519)Gaa>Aaa	p.E1173K	PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.E1102K|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.E1036K|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.E1173K|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.E1036K			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1036					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AATCCTGCTTCCTCAATTTGA	0.532000			T	PDGFRB	MPD								12	69					0	0	1	0	0
WDR96	80217	broad.mit.edu	37	10	105906093	105906093	+	Silent	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:105906093T>C	ENST00000357060.3	-	30	3898	c.3783A>G	c.(3781-3783)gaA>gaG	p.E1261E	WDR96_ENST00000428666.1_Intron	NM_025145.5	NP_079421.5	Q8NDM7	WDR96_HUMAN	WD repeat domain 96	1261										NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(14)|lung(21)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	72						TCCGAACAGCTTCTGAAGTCT	0.413000													17	14					0	0	1	0	0
MROH5	389690	broad.mit.edu	37	8	142487888	142487888	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:142487888G>A	ENST00000430863.1	-	0	1433					NM_207414.2	NP_997297.2			maestro heat-like repeat family member 5																		TCAGACACTGGAGGAGCTCAG	0.612000													13	10					0	0	1	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57076622	57076622	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:57076622G>A	ENST00000532437.1	-	5	3874	c.3563C>T	c.(3562-3564)gCc>gTc	p.A1188V	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.A1188V			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	1188	Acidic.|Gly-rich.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				CTGTCCCACGGCACTCTCCCT	0.617000													51	76					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57206380	57206380	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:57206380C>T	ENST00000343433.6	-	13	1773	c.1693G>A	c.(1693-1695)Gaa>Aaa	p.E565K	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	565										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						CTTAAGTTTTCTTTCGACTTG	0.363000													6	9					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118535150	118535150	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:118535150T>G	ENST00000336338.5	-	36	5365	c.5300A>C	c.(5299-5301)cAa>cCa	p.Q1767P		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1767						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CTGAATGAATTGGCGCATCTG	0.473000													30	37					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109677680	109677680	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:109677680C>T	ENST00000338432.7	+	35	4827	c.4708C>T	c.(4708-4710)Ctg>Ttg	p.L1570L	ACACB_ENST00000377848.3_Silent_p.L1570L|ACACB_ENST00000543201.1_Silent_p.L236L|ACACB_ENST00000377854.5_Silent_p.L1500L			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	1570					acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	GCGGCTGCTCCTGGAGGCCAT	0.607000													14	22					0	0	1	0	0
NPAS4	266743	broad.mit.edu	37	11	66191399	66191399	+	Silent	SNP	C	C	T	rs144417328	byFrequency	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:66191399C>T	ENST00000311034.2	+	7	1214	c.1038C>T	c.(1036-1038)ttC>ttT	p.F346F		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	346					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						TGCCCTCATTCCCTGAAAACA	0.582000													53	107					0	0	1	0	0
HTATSF1	27336	broad.mit.edu	37	X	135593836	135593836	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:135593836G>A	ENST00000535601.1	+	10	2354	c.1932G>A	c.(1930-1932)gaG>gaA	p.E644E	HTATSF1_ENST00000218364.4_Silent_p.E644E	NM_001163280.1	NP_001156752.1	O43719	HTSF1_HUMAN	HIV-1 Tat specific factor 1	644	Asp/Glu-rich (acidic).|Mediates interaction with the P-TEFb complex.				regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent|viral genome replication	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|biliary_tract(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(14)|ovary(3)|prostate(1)	30	Acute lymphoblastic leukemia(192;0.000127)					AGTCTGATGAGAAAGAGGATG	0.403000													22	42					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29608162	29608162	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:29608162G>A	ENST00000431530.3	+	2	2434	c.2376G>A	c.(2374-2376)aaG>aaA	p.K792K		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	782	Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						CATCTGCAAAGAGCAGGATTC	0.517000													41	16					0	0	1	0	0
CCT3	7203	broad.mit.edu	37	1	156280936	156280936	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:156280936G>A	ENST00000295688.3	-	12	1486	c.1206C>T	c.(1204-1206)ctC>ctT	p.L402L	CCT3_ENST00000472765.2_Silent_p.L357L|CCT3_ENST00000368261.3_Silent_p.L357L|CCT3_ENST00000368259.2_Silent_p.L364L	NM_005998.4	NP_005989.3	P49368	TCPG_HUMAN	chaperonin containing TCP1, subunit 3 (gamma)	402					'de novo' posttranslational protein folding	cytoskeleton|cytosol|plasma membrane	ATP binding|unfolded protein binding	p.L402L(1)		endometrium(4)|large_intestine(1)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22	Hepatocellular(266;0.158)					GAGGGTCCAGGAGAACATTGC	0.532000													16	15					0	0	1	0	0
NLGN4X	57502	broad.mit.edu	37	X	5811619	5811619	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:5811619G>A	ENST00000381095.3	-	6	2317	c.1690C>T	c.(1690-1692)Ccc>Tcc	p.P564S	NLGN4X_ENST00000538097.1_Missense_Mutation_p.P564S|NLGN4X_ENST00000381093.2_Missense_Mutation_p.P584S|NLGN4X_ENST00000381092.1_Missense_Mutation_p.P564S|NLGN4X_ENST00000275857.6_Missense_Mutation_p.P564S	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	564					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						TGGTCTTTGGGATTATACTTG	0.458000													29	45					0	0	1	0	0
KRTAP5-1	387264	broad.mit.edu	37	11	1605798	1605798	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:1605798C>T	ENST00000382171.2	-	1	715	c.682G>A	c.(682-684)Gga>Aga	p.G228R	KRTAP5-AS1_ENST00000534077.1_RNA|KRTAP5-AS1_ENST00000524947.1_RNA|KRTAP5-AS1_ENST00000424148.1_RNA|KRTAP5-AS1_ENST00000532922.1_RNA	NM_001005922.1	NP_001005922.1	Q6L8H4	KRA51_HUMAN	keratin associated protein 5-1	228	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(3)|kidney(1)|lung(9)|skin(2)|upper_aerodigestive_tract(1)	16		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCGCAGCCTCCCTTAGACCCC	0.642000													41	63					0	0	1	0	0
RAD9A	5883	broad.mit.edu	37	11	67161204	67161204	+	Missense_Mutation	SNP	C	C	T	rs140448721		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:67161204C>T	ENST00000307980.2	+	5	485	c.392C>T	c.(391-393)tCc>tTc	p.S131F		NM_001243224.1|NM_004584.2	NP_001230153.1|NP_004575.1	Q99638	RAD9A_HUMAN	RAD9 homolog A (S. pombe)	131					DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint	nucleoplasm	3'-5' exonuclease activity|exodeoxyribonuclease III activity|histone deacetylase binding|protein kinase binding|SH3 domain binding			lung(7)|upper_aerodigestive_tract(1)	8			BRCA - Breast invasive adenocarcinoma(15;8.53e-07)			GACTGTGAGTCCCTGCAGGCC	0.672000								Other conserved DNA damage response genes					7	15					0	0	1	0	0
EEA1	8411	broad.mit.edu	37	12	93209994	93209994	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:93209994G>A	ENST00000322349.8	-	15	2175	c.1911C>T	c.(1909-1911)gtC>gtT	p.V637V		NM_003566.3	NP_003557.2	Q15075	EEA1_HUMAN	early endosome antigen 1	637	Gln/Glu/Lys-rich.				early endosome to late endosome transport|synaptic vesicle to endosome fusion|vesicle fusion	cytosol|early endosome membrane|extrinsic to plasma membrane|membrane fraction	1-phosphatidylinositol binding|calmodulin binding|GTP-dependent protein binding|protein homodimerization activity|zinc ion binding			endometrium(5)|kidney(5)|large_intestine(11)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	36						CAAGCTGGGAGACCTTCTCCT	0.358000													12	23					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51947229	51947229	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:51947229G>A	ENST00000371117.3	-	4	517	c.242C>T	c.(241-243)cCt>cTt	p.P81L	PKHD1_ENST00000340994.4_Missense_Mutation_p.P81L	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	81	IPT/TIG 1; atypical.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CAAGAAAACAGGAAAGACGTC	0.498000													65	131					0	0	1	0	0
CLTC	1213	broad.mit.edu	37	17	57741223	57741223	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:57741223G>A	ENST00000269122.3	+	9	1663	c.1389G>A	c.(1387-1389)ctG>ctA	p.L463L	CLTC_ENST00000579456.1_Intron|CLTC_ENST00000393043.1_Silent_p.L463L	NM_004859.3	NP_004850.1	Q00610	CLH1_HUMAN	clathrin, heavy chain (Hc)	463	Binding site for the uncoating ATPase, involved in lattice disassembly (Potential).|Globular terminal domain.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	breast(2)|large_intestine(6)|ovary(1)	9	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					CTGAAGAACTGGGTGATCTTG	0.413000			T	"""ALK, TFE3"""	"""ALCL, renal """								10	31					0	0	1	0	0
MAGI1	9223	broad.mit.edu	37	3	65350614	65350614	+	Silent	SNP	C	C	T	rs149841839	byFrequency	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:65350614C>T	ENST00000330909.8	-	20	3287	c.3288G>A	c.(3286-3288)tcG>tcA	p.S1096S	MAGI1_ENST00000497477.2_Silent_p.S1001S|MAGI1_ENST00000402939.2_Silent_p.S1068S|MAGI1_ENST00000483466.1_Silent_p.S1097S	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	1097					cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		AGGTGGCATTCGAGGACTCTG	0.517000													35	54					0	0	1	0	0
XIST	7503	broad.mit.edu	37	X	73071070	73071070	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:73071070C>T	ENST00000429829.1	-	0	1518					NR_001564.2																						GCAAGCCCGCCATGATGTCCA	0.517000													42	54					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108822756	108822756	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:108822756C>T	ENST00000232603.5	-	4	245	c.163G>A	c.(163-165)Gaa>Aaa	p.E55K	MORC1_ENST00000483760.1_Missense_Mutation_p.E55K|MORC1-AS1_ENST00000480826.1_RNA	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	55					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TGCAGTTTTTCATTATCCACT	0.383000													21	42					0	0	1	0	0
GDF15	9518	broad.mit.edu	37	19	18499348	18499348	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:18499348G>A	ENST00000595973.1	+	3	1081	c.530G>A	c.(529-531)cGg>cAg	p.R177Q	GDF15_ENST00000252809.3_Missense_Mutation_p.R177Q			Q99988	GDF15_HUMAN	growth differentiation factor 15	177					cell-cell signaling|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			kidney(2)|large_intestine(1)|liver(1)|lung(5)|prostate(2)|skin(1)	12						TCGTCCGCACGGCCCCAGCTG	0.731000											OREG0025363	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	3					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35794068	35794068	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:35794068G>A	ENST00000342694.2	+	2	1096	c.841G>A	c.(841-843)Gaa>Aaa	p.E281K		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	281					intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	TCGCACCCGGgaacaggccca	0.567000													15	17					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28576771	28576771	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:28576771G>A	ENST00000434452.1	-	15	2633	c.2479C>T	c.(2479-2481)Ccc>Tcc	p.P827S	DSC3_ENST00000360428.4_Missense_Mutation_p.P827S	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	827					homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CCGAGACGGGGTTGAGTAAAA	0.453000													12	24					0	0	1	0	0
ACBD7	414149	broad.mit.edu	37	10	15120536	15120536	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:15120536C>T	ENST00000356189.5	-	4	307	c.260G>A	c.(259-261)gGa>gAa	p.G87E	ACBD7_ENST00000496890.1_5'UTR	NM_001039844.2	NP_001034933.1	Q8N6N7	ACBD7_HUMAN	acyl-CoA binding domain containing 7	87	ACB.						fatty-acyl-CoA binding			endometrium(1)|lung(4)|prostate(1)	6						ATTCTAAATTCCGTATTTTTC	0.383000													26	11					0	0	1	0	0
ALG10	84920	broad.mit.edu	37	12	34179653	34179653	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:34179653C>T	ENST00000266483.2	+	3	1544	c.1225C>T	c.(1225-1227)Cct>Tct	p.P409S	RP11-847H18.2_ENST00000501954.2_RNA|ALG10_ENST00000538927.1_Intron	NM_032834.3	NP_116223.3	Q5BKT4	AG10A_HUMAN	ALG10, alpha-1,2-glucosyltransferase	409					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	26	Lung NSC(5;3.82e-05)|Acute lymphoblastic leukemia(23;0.0142)|all_hematologic(23;0.0429)	Lung NSC(34;0.204)|all_lung(34;0.235)				TGTTATAGTTCCTCAGAAACT	0.353000													24	56					0	0	1	0	0
MFNG	4242	broad.mit.edu	37	22	37875454	37875454	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:37875454C>T	ENST00000356998.3	-	4	713	c.490G>A	c.(490-492)Gac>Aac	p.D164N	MFNG_ENST00000416983.3_Missense_Mutation_p.D150N	NM_002405.3	NP_002396.2	O00587	MFNG_HUMAN	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	164					pattern specification process	extracellular space|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			large_intestine(2)|lung(2)|skin(1)	5	Melanoma(58;0.0574)					ACATAGACGTCGCGGGCCAGC	0.627000													13	52					0	0	1	0	0
CDH23	64072	broad.mit.edu	37	10	73567159	73567159	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:73567159C>T	ENST00000224721.6	+	57	8324	c.8319C>T	c.(8317-8319)atC>atT	p.I2773I	CDH23_ENST00000398788.3_Silent_p.I528I|CDH23_ENST00000475158.1_3'UTR	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	2768	Cadherin 26.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						ACTACTTCATCGCAGGTGGGG	0.627000													8	6					0	0	1	0	0
COL20A1	57642	broad.mit.edu	37	20	61952405	61952405	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:61952405C>T	ENST00000422202.1	+	25	3283	c.3215C>T	c.(3214-3216)tCc>tTc	p.S1072F	COL20A1_ENST00000326996.6_Missense_Mutation_p.S1065F|COL20A1_ENST00000435874.1_Missense_Mutation_p.S1072F|COL20A1_ENST00000358894.6_Missense_Mutation_p.S1065F			Q9P218	COKA1_HUMAN	collagen, type XX, alpha 1	1065	Collagen-like 1.				cell adhesion	collagen|extracellular space	structural molecule activity			NS(3)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(21)|ovary(1)|prostate(3)|urinary_tract(2)	36	all_cancers(38;1.39e-10)					TCTGCCTGTTCCTGTTCCTCA	0.612000													3	3					0	0	1	0	0
FBXO41	150726	broad.mit.edu	37	2	73491468	73491468	+	Missense_Mutation	SNP	C	C	T	rs142820235	by1000genomes	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:73491468C>T	ENST00000521871.1	-	6	2159	c.1744G>A	c.(1744-1746)Gtg>Atg	p.V582M	FBXO41_ENST00000295133.5_Missense_Mutation_p.V643M|FBXO41_ENST00000520530.2_Missense_Mutation_p.V582M			Q8TF61	FBX41_HUMAN	F-box protein 41	582						intracellular	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|lung(6)|pancreas(1)|prostate(1)|skin(1)	13						TGGCGGGCCACGAAGCGCCAG	0.627000													45	18					0	0	1	0	0
PCDH9	5101	broad.mit.edu	37	13	67799934	67799934	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:67799934G>A	ENST00000544246.1	-	2	3330	c.2639C>T	c.(2638-2640)tCt>tTt	p.S880F	PCDH9_ENST00000377861.3_Missense_Mutation_p.S880F|PCDH9_ENST00000328454.5_Missense_Mutation_p.S880F|PCDH9_ENST00000456367.1_Missense_Mutation_p.S880F|PCDH9_ENST00000377865.2_Missense_Mutation_p.S880F	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	880					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		GTTCAAAAGAGAGCTTTTGGG	0.453000													24	121					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197346713	197346713	+	RNA	SNP	T	T	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:197346713T>A	ENST00000418868.1	-	0	731					NR_003266.2																						TATCAGGAGATCCAAGGCAAA	0.428000													7	20					0	0	1	0	0
OR56A4	120793	broad.mit.edu	37	11	6024367	6024367	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:6024367C>T	ENST00000330728.4	-	1	57	c.12G>A	c.(10-12)gtG>gtA	p.V4V		NM_001005179.2	NP_001005179.2	Q8NGH8	O56A4_HUMAN	olfactory receptor, family 56, subfamily A, member 4	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|kidney(4)|large_intestine(5)|lung(17)|ovary(1)|skin(1)|urinary_tract(1)	32		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;7.01e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTTTTAAAATCACTGTCATCA	0.333000													19	31					0	0	1	0	0
HCG17	414778	broad.mit.edu	37	6	30227467	30227467	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:30227467C>T	ENST00000453558.1	-	0	126				HLA-L_ENST00000463348.1_RNA																							TGACCGAGACCTGGGCCGGTG	0.731000													5	18					0	0	1	0	0
POLD1	5424	broad.mit.edu	37	19	50918104	50918104	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:50918104G>A	ENST00000440232.2	+	20	2474	c.2421G>A	c.(2419-2421)aaG>aaA	p.K807K	POLD1_ENST00000599857.1_Silent_p.K807K|POLD1_ENST00000595904.1_Silent_p.K833K	NM_001256849.1|NM_002691.3	NP_001243778.1|NP_002682.2	P28340	DPOD1_HUMAN	polymerase (DNA directed), delta 1, catalytic subunit	807					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|DNA synthesis involved in DNA repair|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|response to UV|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm|nucleotide-excision repair complex	3'-5'-exodeoxyribonuclease activity|chromatin binding|DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		all_neural(266;0.0571)		OV - Ovarian serous cystadenocarcinoma(262;0.00794)|GBM - Glioblastoma multiforme(134;0.0195)		TCAGCAAGAAGCGCTACGCGG	0.667000								DNA polymerases (catalytic subunits)			OREG0025635	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	28					0	0	1	0	0
CFHR1	3078	broad.mit.edu	37	1	196794618	196794618	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:196794618G>A	ENST00000320493.5	+	2	158	c.70G>A	c.(70-72)Gat>Aat	p.D24N	CFHR1_ENST00000367424.3_Missense_Mutation_p.D24N|CFHR2_ENST00000367421.3_Intron|CFHR1_ENST00000498248.1_3'UTR	NM_002113.2	NP_002104.2	Q03591	FHR1_HUMAN	complement factor H-related 1	24	Sushi 1.				complement activation	extracellular space				NS(1)|kidney(1)|large_intestine(2)|lung(7)	11						AACATTTTGTGATTTTCCAAA	0.279000													5	15					0	0	1	0	0
ATP6V1B2	526	broad.mit.edu	37	8	20075711	20075711	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:20075711C>T	ENST00000276390.2	+	13	1354	c.1314C>T	c.(1312-1314)gtC>gtT	p.V438V		NM_001693.3	NP_001684.2	P21281	VATB2_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	438					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|endomembrane system|Golgi apparatus|melanosome|plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(1)|kidney(2)|lung(5)|prostate(1)	9				Colorectal(74;0.0535)|COAD - Colon adenocarcinoma(73;0.211)		TGAAAGCTGTCGTTGGAGAAG	0.443000													27	43					0	0	1	0	0
PCDHA11	56138	broad.mit.edu	37	5	140248703	140248703	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140248703G>A	ENST00000398640.2	+	1	15	c.15G>A	c.(13-15)caG>caA	p.Q5Q	PCDHA3_ENST00000522353.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA5_ENST00000529619.1_Intron	NM_018902.3	NP_061725.1														breast(1)|lung(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTGGTTTTCAGAGAAGGGGAT	0.488000													20	50					0	0	1	0	0
RUSC2	9853	broad.mit.edu	37	9	35560511	35560511	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:35560511C>T	ENST00000455600.1	+	10	4443	c.3874C>T	c.(3874-3876)Cct>Tct	p.P1292S		NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1292						cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			TTCCAGGTTCCCTCGTGGTAG	0.652000													22	26					0	0	1	0	0
UGT2B28	54490	broad.mit.edu	37	4	70156454	70156454	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:70156454C>T	ENST00000335568.5	+	5	1237	c.1235C>T	c.(1234-1236)gCt>gTt	p.A412V	UGT2B28_ENST00000511240.1_Intron	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	412					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	AAGGGAGCAGCTGTTAGACTG	0.443000													45	16					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48626134	48626134	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:48626134C>T	ENST00000328333.8	-	19	2635	c.2528G>A	c.(2527-2529)cGa>cAa	p.R843Q	COL7A1_ENST00000454817.1_Missense_Mutation_p.R843Q	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	843	Fibronectin type-III 7.|Nonhelical region (NC1).				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TGCAGTCACTCGCACTGAGTA	0.612000													20	34					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47511163	47511163	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:47511163C>T	ENST00000285039.7	-	8	1170	c.871G>A	c.(871-873)Gga>Aga	p.G291R		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	291	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GTGTCTCCTCCCTGTGATGTA	0.522000													20	22					0	0	1	0	0
RP11-344E13.3	0	broad.mit.edu	37	17	20805659	20805659	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:20805659G>A	ENST00000577537.1	+	0	843				RP11-344E13.3_ENST00000577860.1_RNA|RP11-344E13.3_ENST00000439794.2_RNA|RP11-344E13.3_ENST00000583962.1_RNA|RP11-344E13.3_ENST00000417232.2_RNA																							TCCCATGTAGGAAAACGTGTC	0.582000													31	10					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435994	158435994	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:158435994C>T	ENST00000289451.2	+	1	723	c.643C>T	c.(643-645)Cta>Tta	p.L215L		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	215					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					GCTACTTATCCTAGTCTCCTA	0.488000													34	40					0	0	1	0	0
HEPH	9843	broad.mit.edu	37	X	65393459	65393459	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:65393459G>A	ENST00000519389.1	+	4	782	c.603G>A	c.(601-603)ggG>ggA	p.G201G	HEPH_ENST00000441993.2_Silent_p.G150G|HEPH_ENST00000374727.3_Silent_p.G150G|HEPH_ENST00000343002.2_Silent_p.G147G|HEPH_ENST00000419594.1_Silent_p.G150G|HEPH_ENST00000336279.5_5'UTR			Q9BQS7	HEPH_HUMAN	hephaestin	147	Plastocyanin-like 1.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						GCTCCTCTGGGCCACTGAAAG	0.527000													8	13					0	0	1	0	0
ACTC1	70	broad.mit.edu	37	15	35085669	35085669	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:35085669G>A	ENST00000290378.4	-	3	886	c.231C>T	c.(229-231)atC>atT	p.I77I	RP11-814P5.1_ENST00000503496.1_RNA	NM_005159.4	NP_005150.1	P68032	ACTC_HUMAN	actin, alpha, cardiac muscle 1	77					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|lung(14)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)	31		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		AGTTGGTGATGATACCATGCT	0.562000													19	44					0	0	1	0	0
TMC7	79905	broad.mit.edu	37	16	19046997	19046997	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:19046997G>A	ENST00000421369.3	+	7	1085		c.e7-1		TMC7_ENST00000569532.1_Splice_Site|TMC7_ENST00000561963.1_Splice_Site|TMC7_ENST00000304381.5_Splice_Site	NM_001160364.1	NP_001153836.1	Q7Z402	TMC7_HUMAN	transmembrane channel-like 7							integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	28						TTTGGGGTCAGGTCGGTGGAA	0.433000													16	32					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73848702	73848702	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:73848702C>T	ENST00000523207.1	+	3	1700	c.1112C>T	c.(1111-1113)tCa>tTa	p.S371L		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	371					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding	p.S371L(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			ATCCCTGCATCATTTTGGTGG	0.433000													29	50					0	0	1	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72205785	72205785	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:72205785G>A	ENST00000555818.1	+	22	5670	c.5322G>A	c.(5320-5322)gaG>gaA	p.E1774E	SIPA1L1_ENST00000537413.1_Silent_p.E1227E|SIPA1L1_ENST00000554874.1_3'UTR|SIPA1L1_ENST00000381232.3_Silent_p.E1753E|SIPA1L1_ENST00000358550.2_Silent_p.E1752E	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1774					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ACCTGCGAGAGGACAACCTGA	0.537000													19	35					0	0	1	0	0
MPP1	4354	broad.mit.edu	37	X	154020553	154020553	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:154020553G>A	ENST00000413259.3	-	3	412	c.20C>T	c.(19-21)tCg>tTg	p.S7L	MPP1_ENST00000462825.1_Intron|MPP1_ENST00000369534.3_Missense_Mutation_p.S37L|MPP1_ENST00000393531.1_Missense_Mutation_p.S37L	NM_001166462.1	NP_001159934.1	Q00013	EM55_HUMAN	membrane protein, palmitoylated 1, 55kDa	37					regulation of neutrophil chemotaxis|signal transduction	integral to plasma membrane|membrane fraction|stereocilium	guanylate kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(9)|ovary(2)|prostate(1)	21	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CAATGGATGCGATACAGCCTG	0.532000													28	28					0	0	1	0	0
CBX4	8535	broad.mit.edu	37	17	77808599	77808599	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:77808599G>A	ENST00000269397.4	-	5	1019	c.842C>T	c.(841-843)tCc>tTc	p.S281F		NM_003655.2	NP_003646.2	O00257	CBX4_HUMAN	chromobox homolog 4	281	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CACCTCGCCGGACTTGATCTT	0.582000											OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	103	92					0	0	1	0	0
TRIM5	85363	broad.mit.edu	37	11	5686212	5686212	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:5686212G>A	ENST00000305836.5	-	8	1611	c.1309C>T	c.(1309-1311)Cgt>Tgt	p.R437C	TRIM5_ENST00000483835.1_Intron|TRIM5_ENST00000396847.3_3'UTR|TRIM5_ENST00000396853.4_Intron|TRIM5_ENST00000396855.3_Intron|TRIM5_ENST00000380034.3_Missense_Mutation_p.R437C|TRIM5_ENST00000380027.1_Intron			Q9C035	TRIM5_HUMAN	tripartite motif containing 5	437	B30.2/SPRY.				interspecies interaction between organisms|protein trimerization|response to virus	cytoplasm|cytoplasmic mRNA processing body	ligase activity|protein binding|protein homodimerization activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)|Lung NSC(207;0.138)|all_lung(207;0.221)		Epithelial(150;7.21e-09)|BRCA - Breast invasive adenocarcinoma(625;0.139)		ACTCCAACACGATCAGGACAA	0.398000													14	21					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12736261	12736261	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:12736261G>A	ENST00000380682.1	+	16	3822	c.3316G>A	c.(3316-3318)Gga>Aga	p.G1106R		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	1106					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						TGAAAAAAGTGGATTAGAAGC	0.502000													49	83					0	0	1	0	0
COL4A5	1287	broad.mit.edu	37	X	107802372	107802372	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:107802372C>T	ENST00000328300.6	+	3	464	c.220C>T	c.(220-222)Cgg>Tgg	p.R74W	COL4A5_ENST00000361603.2_Missense_Mutation_p.R74W	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	74	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding	p.R74W(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						TCCGGGGCCTCGGGGACAAAA	0.463000									Alport syndrome with Diffuse Leiomyomatosis				16	33					0	0	1	0	0
FMO1	2326	broad.mit.edu	37	1	171227252	171227252	+	Missense_Mutation	SNP	G	G	A	rs138644882		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:171227252G>A	ENST00000354841.4	+	1	157	c.26G>A	c.(25-27)gGa>gAa	p.G9E	FMO1_ENST00000402921.2_Missense_Mutation_p.G9E|FMO1_ENST00000469112.1_3'UTR|FMO1_ENST00000367750.3_Missense_Mutation_p.G9E			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	9					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GCCATTGTGGGAGCTGGGGTC	0.572000													13	41					0	0	1	0	0
GABPA	2551	broad.mit.edu	37	21	27141472	27141472	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr21:27141472C>T	ENST00000354828.3	+	10	1821	c.1294C>T	c.(1294-1296)Cat>Tat	p.H432Y	GABPA_ENST00000400075.3_Missense_Mutation_p.H432Y	NM_001197297.1	NP_001184226.1	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha subunit 60kDa	432					positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding	p.H432N(1)		breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	24						GATGCAGCTCCATGGAATTGC	0.473000													21	10					0	0	1	0	0
DOCK9	23348	broad.mit.edu	37	13	99537975	99537975	+	Silent	SNP	G	G	A	rs62637599		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:99537975G>A	ENST00000376460.1	-	20	2327	c.2247C>T	c.(2245-2247)gtC>gtT	p.V749V	DOCK9_ENST00000339416.2_Silent_p.V750V|DOCK9_ENST00000448493.2_Silent_p.V761V|DOCK9_ENST00000442173.1_Silent_p.V749V	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	750	DHR-1.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GGGTTTCAACGACATCCCTCT	0.403000													36	21					0	0	1	0	0
SLC6A14	11254	broad.mit.edu	37	X	115582805	115582805	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:115582805G>A	ENST00000371900.4	+	8	1217	c.1129G>A	c.(1129-1131)Gga>Aga	p.G377R		NM_007231.3	NP_009162.1	Q9UN76	S6A14_HUMAN	solute carrier family 6 (amino acid transporter), member 14	377					cellular amino acid metabolic process|response to toxin	integral to membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	23					L-Proline(DB00172)	CCATATATCTGGAAAGGAAGT	0.328000													24	35					0	0	1	0	0
CDK18	5129	broad.mit.edu	37	1	205499447	205499447	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:205499447C>T	ENST00000360066.2	+	14	1583	c.1282C>T	c.(1282-1284)Ctg>Ttg	p.L428L	CDK18_ENST00000429964.2_Silent_p.L428L|CDK18_ENST00000509056.1_3'UTR|CDK18_ENST00000506784.1_Silent_p.L458L	NM_002596.3|NM_212502.2|NM_212503.2	NP_002587.2|NP_997667.1|NP_997668.1	Q07002	CDK18_HUMAN	cyclin-dependent kinase 18	426							ATP binding|cyclin-dependent protein kinase activity|protein binding|signal transducer activity			breast(2)|endometrium(2)|large_intestine(2)|lung(10)|stomach(2)|urinary_tract(1)	19						CTTCCGGTCTCTGGGAGAGCG	0.607000													24	44					0	0	1	0	0
TMC5	79838	broad.mit.edu	37	16	19452009	19452009	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:19452009C>T	ENST00000396229.2	+	3	1398	c.649C>T	c.(649-651)Cca>Tca	p.P217S	TMC5_ENST00000541464.1_Missense_Mutation_p.P217S|TMC5_ENST00000381414.4_Missense_Mutation_p.P217S|TMC5_ENST00000542583.2_Missense_Mutation_p.P217S	NM_001105248.1	NP_001098718.1	Q6UXY8	TMC5_HUMAN	transmembrane channel-like 5	217						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(3)|liver(2)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						ACCTAACTCTCCACCCTTTTT	0.453000													15	31					0	0	1	0	0
TLR6	10333	broad.mit.edu	37	4	38830454	38830454	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:38830454T>C	ENST00000436693.2	-	2	760	c.641A>G	c.(640-642)aAc>aGc	p.N214S	TLR6_ENST00000381950.1_Missense_Mutation_p.N214S	NM_006068.4	NP_006059.2	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6	214					activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						AACTGATATGTTCACTTGGAT	0.303000													11	24					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168212946	168212946	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:168212946C>T	ENST00000519560.1	-	12	1536	c.1117G>A	c.(1117-1119)Gga>Aga	p.G373R	SLIT3_ENST00000332966.8_Missense_Mutation_p.G373R|SLIT3_ENST00000404867.3_Missense_Mutation_p.G373R	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	373					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCAAACAGTCCCTTGACAATC	0.512000													9	26					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143094251	143094251	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:143094251C>T	ENST00000367603.2	-	5	2367	c.1625G>A	c.(1624-1626)aGa>aAa	p.R542K	HIVEP2_ENST00000367604.1_Missense_Mutation_p.R542K|HIVEP2_ENST00000012134.2_Missense_Mutation_p.R542K	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	542					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		TGAGTTGCTTCTAATAAGGGG	0.438000													20	10					0	0	1	0	0
MAP3K14	9020	broad.mit.edu	37	17	43351890	43351890	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:43351890G>A	ENST00000344686.2	-	0	1466							Q99558	M3K14_HUMAN	mitogen-activated protein kinase kinase kinase 14						cellular response to mechanical stimulus|I-kappaB kinase/NF-kappaB cascade|immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade|T cell costimulation	cytosol	ATP binding|MAP kinase kinase kinase activity|NF-kappaB-inducing kinase activity|protein binding			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27						TCCATACAAAGGGACAATTCT	0.547000													12	22					0	0	1	0	0
MRGPRE	116534	broad.mit.edu	37	11	3249787	3249787	+	Silent	SNP	G	G	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:3249787G>C	ENST00000389832.5	-	2	549	c.243C>G	c.(241-243)gtC>gtG	p.V81V	AC109309.4_ENST00000418995.2_RNA|MRGPRE_ENST00000436689.2_Silent_p.V80V			Q86SM8	MRGRE_HUMAN	MAS-related GPR, member E	80						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(6)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	19		Medulloblastoma(188;0.00106)|all_epithelial(84;0.00111)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00529)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCAAGTCGGGGACGATGGCCA	0.617000													35	42					0	0	1	0	0
IPO11	51194	broad.mit.edu	37	5	61811238	61811238	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:61811238G>A	ENST00000325324.6	+	20	1975	c.1806G>A	c.(1804-1806)ttG>ttA	p.L602L	IPO11_ENST00000409296.3_Silent_p.L642L|KIF2A_ENST00000509663.2_3'UTR	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11	602						cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		TGGGATGTTTGGTACAATATT	0.343000													20	35					0	0	1	0	0
DCAF12L2	340578	broad.mit.edu	37	X	125298807	125298807	+	Silent	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:125298807G>T	ENST00000538699.1	-	2	1181	c.1101C>A	c.(1099-1101)acC>acA	p.T367T	DCAF12L2_ENST00000360028.2_Silent_p.T367T	NM_001013628.2	NP_001013650.1	Q5VW00	DC122_HUMAN	DDB1 and CUL4 associated factor 12-like 2	367										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(36)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(3)	64						AACCATGGCCGGTGCCCACAG	0.657000													30	42					2.65835e-16	2.71132e-16	1	1	0
SCMH1	22955	broad.mit.edu	37	1	41579128	41579128	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:41579128G>A	ENST00000402904.2	-	8	910	c.542C>T	c.(541-543)cCt>cTt	p.P181L	SCMH1_ENST00000361705.3_Missense_Mutation_p.P134L|SCMH1_ENST00000337495.5_Missense_Mutation_p.P191L|SCMH1_ENST00000397174.2_Missense_Mutation_p.P161L|SCMH1_ENST00000372595.1_Missense_Mutation_p.P120L|SCMH1_ENST00000326197.7_Missense_Mutation_p.P181L|SCMH1_ENST00000361191.5_Missense_Mutation_p.P120L|SCMH1_ENST00000397171.2_Missense_Mutation_p.P120L|SCMH1_ENST00000372597.1_Missense_Mutation_p.P134L|SCMH1_ENST00000456518.2_Intron|SCMH1_ENST00000372596.1_Missense_Mutation_p.P120L	NM_001031694.2	NP_001026864.1	Q96GD3	SCMH1_HUMAN	sex comb on midleg homolog 1 (Drosophila)	181					anatomical structure morphogenesis|gene silencing|multicellular organismal development|negative regulation of transcription, DNA-dependent		DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(2)|pancreas(2)|upper_aerodigestive_tract(1)	15	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)|Breast(333;0.162)	Myeloproliferative disorder(586;0.0393)				AATGAAATGAGGGTTCTTCCT	0.512000													15	18					0	0	1	0	0
GFPT2	9945	broad.mit.edu	37	5	179757755	179757755	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:179757755C>T	ENST00000253778.8	-	6	648	c.479G>A	c.(478-480)aGa>aAa	p.R160K		NM_005110.2	NP_005101.1	O94808	GFPT2_HUMAN	glutamine-fructose-6-phosphate transaminase 2	160	Glutamine amidotransferase type-2.				dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34	all_cancers(89;4.97e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	Medulloblastoma(196;0.0392)|all_neural(177;0.0529)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		L-Glutamine(DB00130)	CTCAGTTTCTCTGTTGTCGAA	0.428000													10	22					0	0	1	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589270	140589270	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140589270T>G	ENST00000239450.2	+	1	980	c.791T>G	c.(790-792)gTc>gGc	p.V264G	PCDHB12_ENST00000541609.1_Intron	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		264	Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTTGTGACCGTCTCAGCCTGG	0.423000													47	52					0	0	1	0	0
MTMR10	54893	broad.mit.edu	37	15	31239361	31239361	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:31239361G>T	ENST00000435680.1	-	14	1617	c.1520C>A	c.(1519-1521)tCc>tAc	p.S507Y	MTMR10_ENST00000314404.8_Missense_Mutation_p.S259Y|MTMR10_ENST00000425768.1_3'UTR|MTMR10_ENST00000563714.1_Missense_Mutation_p.S425Y	NM_017762.2	NP_060232.2	Q9NXD2	MTMRA_HUMAN	myotubularin related protein 10	507	Myotubularin phosphatase.						phosphatase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|ovary(1)|upper_aerodigestive_tract(1)	9		all_lung(180;2.81e-11)		all cancers(64;7.26e-15)|Epithelial(43;7.2e-11)|GBM - Glioblastoma multiforme(186;0.000158)|BRCA - Breast invasive adenocarcinoma(123;0.00426)|Lung(196;0.174)		CTGGTGAGGGGAGTTGAACAG	0.468000													26	66					1.7881e-09	1.80845e-09	1	1	0
GZMK	3003	broad.mit.edu	37	5	54329613	54329613	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:54329613G>A	ENST00000231009.2	+	5	724	c.654G>A	c.(652-654)ttG>ttA	p.L218L	CTD-2313F11.1_ENST00000595218.1_RNA	NM_002104.2	NP_002095.1	P49863	GRAK_HUMAN	granzyme K (granzyme 3; tryptase II)	218	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(4)	15		Lung NSC(810;4.08e-05)|Breast(144;0.0433)|Prostate(74;0.183)				GGGGCCCCTTGATCTGTAAAG	0.458000													9	26					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150945466	150945466	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:150945466G>A	ENST00000261800.5	-	1	3039	c.3027C>T	c.(3025-3027)gcC>gcT	p.A1009A		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	1009	Cadherin 8.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAGTCCTGCGGGCTAGGGGCC	0.602000													13	13					0	0	1	0	0
RTDR1	27156	broad.mit.edu	37	22	23401670	23401670	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:23401670G>A	ENST00000216036.4	-	7	1213	c.1017C>T	c.(1015-1017)atC>atT	p.I339I		NM_014433.2	NP_055248.1	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region gene 1	339							binding			breast(1)|endometrium(3)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)|stomach(1)|urinary_tract(1)	18	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		CACTGATGGCGATCCGGGCTG	0.547000													38	42					0	0	1	0	0
NR4A3	8013	broad.mit.edu	37	9	102590756	102590756	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:102590756C>T	ENST00000330847.1	+	2	509	c.465C>T	c.(463-465)acC>acT	p.T155T	NR4A3_ENST00000395097.2_Silent_p.T144T|NR4A3_ENST00000338488.4_Silent_p.T144T			Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	144					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		TCF12/NR4A3(2)|TAF15/NR4A3(33)|EWSR1/NR4A3(146)|TFG/NR4A3(2)				Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				CCACCCCCACCACGCCGGCCT	0.706000			T	EWSR1	extraskeletal myxoid chondrosarcoma								34	6					0	0	1	0	0
PDLIM4	8572	broad.mit.edu	37	5	131607493	131607493	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:131607493C>T	ENST00000253754.3	+	6	744	c.680C>T	c.(679-681)cCc>cTc	p.P227L	PDLIM4_ENST00000484620.1_3'UTR|PDLIM4_ENST00000379018.3_Intron|P4HA2_ENST00000471826.1_Intron	NM_001131027.1|NM_003687.3	NP_001124499.1|NP_003678.2	P50479	PDLI4_HUMAN	PDZ and LIM domain 4	227							protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|urinary_tract(1)	10			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGGGATTGGCCCGGGCCTGGC	0.701000													14	19					0	0	1	0	0
SMAD4	4089	broad.mit.edu	37	18	48604768	48604768	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:48604768C>T	ENST00000342988.3	+	12	2128	c.1590C>T	c.(1588-1590)caC>caT	p.H530H	SMAD4_ENST00000588745.1_Silent_p.H434H|SMAD4_ENST00000398417.2_Silent_p.H530H|SMAD4_ENST00000586253.1_3'UTR	NM_005359.5	NP_005350.1	Q13485	SMAD4_HUMAN	SMAD family member 4	530	MH2.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(36)|p.?(2)		NS(2)|biliary_tract(19)|breast(9)|central_nervous_system(2)|endometrium(2)|gastrointestinal_tract_(site_indeterminate)(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(142)|liver(2)|lung(27)|oesophagus(4)|ovary(7)|pancreas(180)|prostate(3)|skin(1)|small_intestine(9)|stomach(5)|testis(2)|thyroid(19)|upper_aerodigestive_tract(10)|urinary_tract(2)|vulva(1)	454		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		TTCACTTACACCGGGCCCTCC	0.483000													8	30					0	0	1	0	0
OR4C15	81309	broad.mit.edu	37	11	55322751	55322751	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:55322751G>A	ENST00000314644.2	+	1	969	c.969G>A	c.(967-969)atG>atA	p.M323I		NM_001001920.1	NP_001001920.1	Q8NGM1	OR4CF_HUMAN	olfactory receptor, family 4, subfamily C, member 15	269					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.M323I(1)		central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(31)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(5)	56						TTGACAAAATGGCGGCAATAT	0.383000										HNSCC(20;0.049)			29	58					0	0	1	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107459537	107459537	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:107459537G>A	ENST00000409382.3	-	2	1507	c.897C>T	c.(895-897)gtC>gtT	p.V299V	ST6GAL2_ENST00000361686.4_Silent_p.V299V|ST6GAL2_ENST00000409087.3_Silent_p.V299V	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	299					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						CTGCAGACATGACGACAGCGC	0.687000													3	2					0	0	1	0	0
CD163	9332	broad.mit.edu	37	12	7640469	7640469	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:7640469G>A	ENST00000359156.4	-	7	1837	c.1635C>T	c.(1633-1635)ttC>ttT	p.F545F	CD163_ENST00000541972.1_Silent_p.F533F|CD163_ENST00000396620.3_Silent_p.F545F|CD163_ENST00000432237.2_Silent_p.F545F	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	545	SRCR 5.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						CCTCACACTGGAATTCTTCAG	0.532000													12	31					0	0	1	0	0
GHSR	2693	broad.mit.edu	37	3	172165602	172165602	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:172165602G>A	ENST00000241256.2	-	1	644	c.602C>T	c.(601-603)aCc>aTc	p.T201I	GHSR_ENST00000427970.1_Missense_Mutation_p.T201I	NM_198407.2	NP_940799.1	Q92847	GHSR_HUMAN	growth hormone secretagogue receptor	201					actin polymerization or depolymerization|adult feeding behavior|decidualization|growth hormone secretion|hormone-mediated signaling pathway|negative regulation of inflammatory response|negative regulation of interleukin-1 beta production|negative regulation of interleukin-6 biosynthetic process|negative regulation of tumor necrosis factor biosynthetic process|positive regulation of appetite|positive regulation of multicellular organism growth	cell surface|integral to membrane|membrane raft|neuron projection|plasma membrane	growth hormone secretagogue receptor activity|growth hormone-releasing hormone receptor activity			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	33	Ovarian(172;0.00143)|Breast(254;0.197)		Lung(28;3.93e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CGCAAACTCGGTGGGGCGGCA	0.627000													8	23					0	0	1	0	0
ITPKB	3707	broad.mit.edu	37	1	226924376	226924376	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:226924376G>A	ENST00000429204.1	-	2	1111	c.784C>T	c.(784-786)Cct>Tct	p.P262S	ITPKB_ENST00000272117.3_Missense_Mutation_p.P262S|ITPKB_ENST00000366784.1_Missense_Mutation_p.P262S	NM_002221.3	NP_002212.3	P27987	IP3KB_HUMAN	inositol-trisphosphate 3-kinase B	262							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				GGACTGGCAGGGATACCCTTC	0.597000													12	35					0	0	1	0	0
ZNF560	147741	broad.mit.edu	37	19	9578713	9578713	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:9578713G>A	ENST00000301480.4	-	10	1123	c.910C>T	c.(910-912)Cag>Tag	p.Q304*		NM_152476.2	NP_689689.2	Q96MR9	ZN560_HUMAN	zinc finger protein 560	304					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(16)|liver(2)|lung(24)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	65						AGGTATGACTGATAAATGAAG	0.413000													19	35					0	0	1	0	0
SLC52A3	113278	broad.mit.edu	37	20	744300	744300	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:744300G>A	ENST00000381944.3	-	3	1156	c.915C>T	c.(913-915)acC>acT	p.T305T	SLC52A3_ENST00000217254.7_Silent_p.T305T|SLC52A3_ENST00000473664.1_Intron			Q9NQ40	RFT2_HUMAN	solute carrier family 52 (riboflavin transporter), member 3	305					sensory perception of sound	integral to plasma membrane	riboflavin transporter activity										AGGCCACCAGGGTATAGATGA	0.642000													23	38					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26423383	26423383	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:26423383C>T	ENST00000335473.7	+	43	7693	c.7443C>T	c.(7441-7443)aaC>aaT	p.N2481N	MYO18B_ENST00000536101.1_Silent_p.N2481N|MYO18B_ENST00000407587.2_Silent_p.N2482N	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2481						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AAGAGGCTAACCGTTCCTTTC	0.567000													11	23					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116075333	116075333	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:116075333C>T	ENST00000369271.3	-	6	898	c.598G>A	c.(598-600)Gac>Aac	p.D200N	AFAP1L2_ENST00000304129.4_Missense_Mutation_p.D200N|AFAP1L2_ENST00000545353.1_Missense_Mutation_p.D253N	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	200	PH 1.				inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		AGCCTGTTGTCCTTGATGACA	0.627000													9	7					0	0	1	0	0
IQGAP2	10788	broad.mit.edu	37	5	75896636	75896636	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:75896636G>A	ENST00000274364.6	+	11	1368		c.e11-1		IQGAP2_ENST00000379730.3_Splice_Site	NM_006633.2	NP_006624.2	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2						small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(23)|ovary(6)|prostate(1)|skin(3)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	68		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		TTTTCCAACAGAACTACTTGG	0.433000													16	19					0	0	1	0	0
CLU	1191	broad.mit.edu	37	8	27463918	27463918	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:27463918A>T	ENST00000316403.10	-	4	775	c.370T>A	c.(370-372)Ttc>Atc	p.F124I	CLU_ENST00000560366.1_Missense_Mutation_p.F176I|CLU_ENST00000405140.3_Missense_Mutation_p.F124I|CLU_ENST00000546343.1_Missense_Mutation_p.F135I|CLU_ENST00000523500.1_Missense_Mutation_p.F124I			P10909	CLUS_HUMAN	clusterin	124					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)	21		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		CGTGCGTAGAACTTCATGCAG	0.577000													43	57					0	0	1	0	0
DKK2	27123	broad.mit.edu	37	4	107845337	107845337	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:107845337C>T	ENST00000285311.3	-	4	1259	c.554G>A	c.(553-555)cGa>cAa	p.R185Q	DKK2_ENST00000510463.1_Missense_Mutation_p.R139Q|DKK2_ENST00000513208.1_Missense_Mutation_p.R85Q	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	185	DKK-type Cys-2.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		GTCTGATGATCGTAGGCAGGG	0.453000													10	11					0	0	1	0	0
RP11-80F22.9	0	broad.mit.edu	37	16	34713679	34713679	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:34713679C>T	ENST00000569028.2	-	0	289																											AGGAGGGGGTCTCGGCTTTTT	0.502000													5	3					0	0	1	0	0
OXA1L	5018	broad.mit.edu	37	14	23235902	23235902	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:23235902C>T	ENST00000285848.5	+	1	172	c.172C>T	c.(172-174)Ccg>Tcg	p.P58S	OXA1L_ENST00000604262.1_5'UTR	NM_005015.3	NP_005006.3	Q15070	OXA1L_HUMAN	oxidase (cytochrome c) assembly 1-like	0					aerobic respiration|mitochondrial proton-transporting ATP synthase complex assembly|mitochondrial respiratory chain complex I assembly|negative regulation of ATPase activity|negative regulation of oxidoreductase activity|protein insertion into membrane|protein tetramerization	integral to mitochondrial membrane|mitochondrial respiratory chain|protein complex	protein homodimerization activity|ribosome binding	p.P58S(1)		central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(5)|skin(2)	19	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.0096)		AAGTCCTCTTCCGGGCAAAAT	0.607000													43	66					0	0	1	0	0
IVL	3713	broad.mit.edu	37	1	152882675	152882675	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:152882675G>A	ENST00000368764.3	+	2	466	c.402G>A	c.(400-402)ctG>ctA	p.L134L	IVL_ENST00000392667.2_5'UTR			P07476	INVO_HUMAN	involucrin	134					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			ACCAGCAACTGGATCAAGAGC	0.498000													13	11					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150914097	150914097	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:150914097G>A	ENST00000261800.5	-	12	9312	c.9300C>T	c.(9298-9300)acC>acT	p.T3100T		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	3100	Cadherin 27.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CCACATGGAGGGTGATGTCTG	0.577000													18	25					0	0	1	0	0
FEN1	2237	broad.mit.edu	37	11	61563658	61563658	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:61563658C>T	ENST00000305885.2	+	2	1238	c.825C>T	c.(823-825)ctC>ctT	p.L275L	FADS2_ENST00000574708.1_Intron	NM_004111.5	NP_004102.1	P39748	FEN1_HUMAN	flap structure-specific endonuclease 1	275					base-excision repair|DNA replication, removal of RNA primer|double-strand break repair|phosphatidylinositol-mediated signaling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|UV protection	mitochondrion|nucleolus|nucleoplasm	5'-3' exonuclease activity|5'-flap endonuclease activity|damaged DNA binding|double-stranded DNA binding|double-stranded DNA specific exodeoxyribonuclease activity|metal ion binding|protein binding|ribonuclease H activity			endometrium(1)|large_intestine(4)|lung(1)|ovary(1)	7						AAAATTGGCTCCACAAGGAGG	0.562000								Editing and processing nucleases					13	22					0	0	1	0	0
CORIN	10699	broad.mit.edu	37	4	47644047	47644047	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:47644047C>T	ENST00000273857.4	-	16	2087	c.2088G>A	c.(2086-2088)gtG>gtA	p.V696V	CORIN_ENST00000502252.1_Silent_p.V629V|CORIN_ENST00000508498.1_Silent_p.V557V|CORIN_ENST00000505909.1_Silent_p.V659V	NM_006587.2	NP_006578.2	Q9Y5Q5	CORIN_HUMAN	corin, serine peptidase	696	SRCR.				peptide hormone processing|regulation of systemic arterial blood pressure by atrial natriuretic peptide	integral to membrane|plasma membrane	scavenger receptor activity|serine-type endopeptidase activity|serine-type exopeptidase activity			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(18)|lung(39)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	79						AAGAGGAGTTCACATTTATAG	0.448000													16	16					0	0	1	0	0
ATCAY	85300	broad.mit.edu	37	19	3905537	3905537	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:3905537C>T	ENST00000450849.2	+	4	709	c.242C>T	c.(241-243)tCc>tTc	p.S81F	ATCAY_ENST00000301260.6_Missense_Mutation_p.S81F|ATCAY_ENST00000398448.3_Missense_Mutation_p.S87F|ATCAY_ENST00000600960.1_Missense_Mutation_p.S81F	NM_033064.4	NP_149053.1	Q86WG3	ATCAY_HUMAN	ataxia, cerebellar, Cayman type	81					transport		protein binding			breast(1)|endometrium(2)|kidney(2)|lung(2)	7		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		TCCCTGCTGTCCGATGACTTC	0.542000													13	39					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559773	140559773	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140559773G>A	ENST00000239444.2	+	1	2403	c.2158G>A	c.(2158-2160)Gcg>Acg	p.A720T		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		720					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGGAGCAGGGCGGCCTCGGT	0.637000													50	70					0	0	1	0	0
POLG2	11232	broad.mit.edu	37	17	62481960	62481960	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:62481960A>G	ENST00000539111.2	-	5	1062	c.995T>C	c.(994-996)gTt>gCt	p.V332A	POLG2_ENST00000582501.1_5'UTR	NM_007215.3	NP_009146.2	Q9UHN1	DPOG2_HUMAN	polymerase (DNA directed), gamma 2, accessory subunit	332					DNA repair|DNA-dependent DNA replication|glycyl-tRNA aminoacylation	mitochondrial chromosome	ATP binding|DNA-directed DNA polymerase activity|glycine-tRNA ligase activity|identical protein binding|single-stranded DNA binding			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(1)|lung(4)|skin(2)|stomach(1)|urinary_tract(1)	15	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;4.97e-11)			AACACAAGGAACCACATTTTT	0.408000													12	28					0	0	1	0	0
MARK3	4140	broad.mit.edu	37	14	103932349	103932349	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:103932349C>T	ENST00000429436.2	+	9	1328	c.818C>T	c.(817-819)cCc>cTc	p.P273L	MARK3_ENST00000553942.1_Missense_Mutation_p.P273L|MARK3_ENST00000416682.2_Missense_Mutation_p.P296L|MARK3_ENST00000335102.5_Missense_Mutation_p.P296L|MARK3_ENST00000303622.9_Missense_Mutation_p.P273L|MARK3_ENST00000216288.7_Missense_Mutation_p.P273L|MARK3_ENST00000561071.1_Intron|MARK3_ENST00000440884.3_Missense_Mutation_p.P194L	NM_001128918.1|NM_001128919.1	NP_001122390.1|NP_001122391.1	P27448	MARK3_HUMAN	MAP/microtubule affinity-regulating kinase 3	273	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	30		Melanoma(154;0.155)	Epithelial(46;0.241)			TACAGAATTCCCTTCTACATG	0.398000													17	29					0	0	1	0	0
CAPZB	832	broad.mit.edu	37	1	19683223	19683223	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:19683223G>A	ENST00000264203.3	-	7	1065	c.572C>T	c.(571-573)gCc>gTc	p.A191V	CAPZB_ENST00000375144.1_Missense_Mutation_p.A153V|CAPZB_ENST00000433834.1_Missense_Mutation_p.A194V|CAPZB_ENST00000264202.6_Missense_Mutation_p.A165V|CAPZB_ENST00000401084.2_Missense_Mutation_p.A165V|CAPZB_ENST00000375142.1_Missense_Mutation_p.A165V			P47756	CAPZB_HUMAN	capping protein (actin filament) muscle Z-line, beta	165					actin cytoskeleton organization|actin filament capping|blood coagulation|cellular component movement	cytosol|F-actin capping protein complex|WASH complex	actin binding			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|prostate(1)|urinary_tract(1)	7		Colorectal(325;3.93e-05)|Renal(390;0.000147)|all_lung(284;0.000169)|Lung NSC(340;0.000202)|Breast(348;0.000496)|Ovarian(437;0.00428)|Myeloproliferative disorder(586;0.0262)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Kidney(64;8.63e-06)|BRCA - Breast invasive adenocarcinoma(304;4.06e-05)|KIRC - Kidney renal clear cell carcinoma(64;0.000175)|GBM - Glioblastoma multiforme(114;0.000525)|STAD - Stomach adenocarcinoma(196;0.00779)|READ - Rectum adenocarcinoma(331;0.103)|Lung(427;0.173)		CTTGTAATGGGCGGTGCGACC	0.552000													76	137					0	0	1	0	0
KDM3B	51780	broad.mit.edu	37	5	137734050	137734050	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:137734050G>A	ENST00000314358.5	+	10	3215	c.3015G>A	c.(3013-3015)gaG>gaA	p.E1005E	KDM3B_ENST00000542866.1_Silent_p.E37E|KDM3B_ENST00000394866.1_Silent_p.E661E	NM_016604.3	NP_057688.2	Q7LBC6	KDM3B_HUMAN	lysine (K)-specific demethylase 3B	1005					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(15)|liver(2)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	65						TAATGTCTGAGAAGGAGGCCA	0.478000													18	29					0	0	1	0	0
XAB2	56949	broad.mit.edu	37	19	7689290	7689290	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:7689290G>A	ENST00000358368.4	-	7	901	c.864C>T	c.(862-864)acC>acT	p.T288T	XAB2_ENST00000534844.1_Silent_p.T285T	NM_020196.2	NP_064581.2	Q9HCS7	SYF1_HUMAN	XPA binding protein 2	288					transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	catalytic step 2 spliceosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	26						AGTCCCGCACGGTCATCACTG	0.642000								Direct reversal of damage;Nucleotide excision repair (NER)					19	37					0	0	1	0	0
LIPF	8513	broad.mit.edu	37	10	90427359	90427359	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:90427359G>A	ENST00000394375.3	+	4	282	c.169G>A	c.(169-171)Gaa>Aaa	p.E57K	LIPF_ENST00000355843.2_Missense_Mutation_p.E47K|LIPF_ENST00000238983.4_Missense_Mutation_p.E47K	NM_001198829.1	NP_001185758.1	P07098	LIPG_HUMAN	lipase, gastric	47					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity			NS(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(6)	13		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		ATACCCAAATGAAGAATATGA	0.294000													20	4					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9086692	9086692	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:9086692G>A	ENST00000397910.4	-	1	5326	c.5123C>T	c.(5122-5124)aCt>aTt	p.T1708I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1708	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCCTTCAGTAGTTGACTCAGA	0.488000													29	54					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44815246	44815246	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:44815246G>A	ENST00000372262.3	-	9	2044	c.1644C>T	c.(1642-1644)ttC>ttT	p.F548F	CDH22_ENST00000537909.1_Silent_p.F548F	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	548	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				CAAGCAGAGAGAAATGAGGGT	0.577000													20	29					0	0	1	0	0
CDC42BPG	55561	broad.mit.edu	37	11	64597253	64597253	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:64597253G>A	ENST00000342711.5	-	30	3656	c.3657C>T	c.(3655-3657)atC>atT	p.I1219I		NM_017525.2	NP_059995.2	Q6DT37	MRCKG_HUMAN	CDC42 binding protein kinase gamma (DMPK-like)	1219	CNH.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|centrosome	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(1)|lung(3)	4						GCAGCTCACGGATGCGGCGCT	0.711000													7	18					0	0	1	0	0
PRDM11	56981	broad.mit.edu	37	11	45246334	45246334	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:45246334C>T	ENST00000263765.4	+	8	1660	c.1411C>T	c.(1411-1413)Cct>Tct	p.P471S	PRDM11_ENST00000424263.2_Missense_Mutation_p.P437S|PRDM11_ENST00000530656.1_Missense_Mutation_p.P471S|PRDM11_ENST00000528980.1_Intron|CTD-2560E9.3_ENST00000527450.1_RNA			Q9NQV5	PRD11_HUMAN	PR domain containing 11	471										endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	26						TGGGAAACTTCCTGAGCCCCC	0.512000													52	70					0	0	1	0	0
GRN	2896	broad.mit.edu	37	17	42426860	42426860	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:42426860G>C	ENST00000053867.3	+	3	267	c.205G>C	c.(205-207)Gcc>Ccc	p.A69P	GRN_ENST00000589265.1_Missense_Mutation_p.A69P	NM_002087.2	NP_002078.1	P28799	GRN_HUMAN	granulin	69			A -> T.		signal transduction	extracellular space	cytokine activity|growth factor activity			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		CCACTGCTCTGCCGGCCACTC	0.577000													41	43					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70493873	70493873	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:70493873G>A	ENST00000310961.5	+	19	2133	c.1715G>A	c.(1714-1716)cGa>cAa	p.R572Q	LRRC7_ENST00000415775.2_Intron|RP11-181B18.1_ENST00000414132.1_RNA|LRRC7_ENST00000035383.5_Missense_Mutation_p.R567Q			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	567						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AACCTAAAACGATATCCAACT	0.323000													20	31					0	0	1	0	0
GRAMD1A	57655	broad.mit.edu	37	19	35510183	35510183	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:35510183C>T	ENST00000599564.1	+	13	1634	c.1563C>T	c.(1561-1563)ggC>ggT	p.G521G	CTD-2527I21.14_ENST00000605640.1_RNA|GRAMD1A_ENST00000411896.2_Silent_p.G427G|GRAMD1A_ENST00000504615.2_Silent_p.G200G|GRAMD1A_ENST00000317991.5_Silent_p.G434G			Q96CP6	GRM1A_HUMAN	GRAM domain containing 1A	434						integral to membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	19	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			ACCCACTGGGCCCCAAGAGCG	0.682000													23	26					0	0	1	0	0
CDO1	1036	broad.mit.edu	37	5	115151998	115151998	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:115151998C>T	ENST00000250535.4	-	1	653	c.97G>A	c.(97-99)Gtg>Atg	p.V33M	CDO1_ENST00000502631.1_Intron	NM_001801.2	NP_001792.2	Q16878	CDO1_HUMAN	cysteine dioxygenase type 1	33					inflammatory response|sulfur amino acid biosynthetic process|taurine biosynthetic process	cytosol	cysteine dioxygenase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|skin(5)	11		all_cancers(142;0.0046)|all_epithelial(76;0.000161)|Prostate(80;0.0132)|Ovarian(225;0.0776)		OV - Ovarian serous cystadenocarcinoma(64;7.8e-08)|Epithelial(69;7.32e-07)|all cancers(49;3.24e-05)	L-Cysteine(DB00151)|NADH(DB00157)	ATGGCCTGCACCTCCTCTACA	0.592000													70	76					0	0	1	0	0
RGAG1	57529	broad.mit.edu	37	X	109697146	109697146	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:109697146G>A	ENST00000465301.2	+	3	3547	c.3301G>A	c.(3301-3303)Gac>Aac	p.D1101N	RGAG1_ENST00000540313.1_Missense_Mutation_p.D1101N	NM_020769.2	NP_065820.1	Q8NET4	RGAG1_HUMAN	retrotransposon gag domain containing 1	1101										NS(1)|autonomic_ganglia(1)|breast(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(1)|lung(29)|ovary(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	73						CAAAGCCACAGACTCTGGAGA	0.532000													46	84					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84520255	84520255	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:84520255G>A	ENST00000360700.4	+	6	1796	c.910G>A	c.(910-912)Gat>Aat	p.D304N	ZNF711_ENST00000542798.1_Missense_Mutation_p.D100N|ZNF711_ENST00000276123.3_Missense_Mutation_p.D304N|ZNF711_ENST00000395402.1_Missense_Mutation_p.D282N|ZNF711_ENST00000373165.3_Missense_Mutation_p.D304N			Q9Y462	ZN711_HUMAN	zinc finger protein 711	304					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						AGAAGAAGATGATATCAGTAA	0.403000													21	21					0	0	1	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186946727	186946727	+	Silent	SNP	A	A	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:186946727A>G	ENST00000367466.3	+	16	1919	c.1767A>G	c.(1765-1767)gaA>gaG	p.E589E	PLA2G4A_ENST00000442353.2_Silent_p.E529E	NM_024420.2	NP_077734.1	P47712	PA24A_HUMAN	phospholipase A2, group IVA (cytosolic, calcium-dependent)	589	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|prostate(3)|skin(4)|stomach(1)	53					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	TCCCATAGGAACTTCTACTTG	0.403000													9	20					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216052118	216052118	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:216052118C>T	ENST00000366943.2	-	42	8932	c.8546G>A	c.(8545-8547)gGa>gAa	p.G2849E	USH2A_ENST00000307340.3_Missense_Mutation_p.G2849E			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	2849	Fibronectin type-III 15.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CAAATTAGGTCCATTTGGCTT	0.413000										HNSCC(13;0.011)			7	12					0	0	1	0	0
CHRND	1144	broad.mit.edu	37	2	233398649	233398649	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:233398649G>A	ENST00000258385.3	+	10	1088	c.1056G>A	c.(1054-1056)ctG>ctA	p.L352L	CHRND_ENST00000543200.1_Silent_p.L337L|CHRND_ENST00000457943.2_Silent_p.L158L	NM_000751.2	NP_000742.1	Q07001	ACHD_HUMAN	cholinergic receptor, nicotinic, delta (muscle)	352					muscle contraction|musculoskeletal movement|neuromuscular process|skeletal muscle tissue growth|synaptic transmission	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|liver(1)|lung(17)|ovary(3)|prostate(1)|skin(1)|stomach(1)	34		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.89e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00078)|Lung(119;0.00579)|LUSC - Lung squamous cell carcinoma(224;0.00754)		AGCTCTTCCTGGAGACCCTGC	0.592000													32	14					0	0	1	0	0
OR4M2	390538	broad.mit.edu	37	15	22368704	22368704	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:22368704C>T	ENST00000332663.2	+	1	227	c.129C>T	c.(127-129)atC>atT	p.I43I	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	43					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CAGGAAATATCCTTATCATTT	0.408000													66	181					0	0	1	0	0
SOGA2	23255	broad.mit.edu	37	18	8784547	8784547	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:8784547C>T	ENST00000359865.3	+	6	1579	c.1437C>T	c.(1435-1437)ctC>ctT	p.L479L	SOGA2_ENST00000306329.11_Silent_p.L839L|SOGA2_ENST00000517570.1_Silent_p.L479L|SOGA2_ENST00000400050.3_Silent_p.L479L|SOGA2_ENST00000306285.7_5'UTR	NM_015210.3	NP_056025.2	Q9Y4B5	CC165_HUMAN	SOGA family member 2	830																	ACAGCTTCCTCCATGATGCGG	0.682000													57	111					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179616322	179616322	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:179616322T>C	ENST00000360870.5	-	46	11027	c.10805A>G	c.(10804-10806)cAa>cGa	p.Q3602R	TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	3597							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTCTCATCTTGCCCTTTTTG	0.393000													43	8					0	0	1	0	0
COL7A1	1294	broad.mit.edu	37	3	48616807	48616807	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:48616807C>T	ENST00000328333.8	-	60	5409	c.5302G>A	c.(5302-5304)Gaa>Aaa	p.E1768K	COL7A1_ENST00000454817.1_Missense_Mutation_p.E1768K	NM_000094.3	NP_000085.1	Q02388	CO7A1_HUMAN	collagen, type VII, alpha 1	1768	Triple-helical region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			NS(3)|breast(8)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(57)|ovary(7)|prostate(5)|skin(9)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(5)	137				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTCACCTTTTCTCCTGCTGGG	0.572000													20	25					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189612233	189612233	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:189612233A>G	ENST00000264731.3	+	14	2074	c.1985A>G	c.(1984-1986)aAc>aGc	p.N662S	TP63_ENST00000449992.1_Missense_Mutation_p.N483S|TP63_ENST00000354600.5_Missense_Mutation_p.N568S|TP63_ENST00000320472.5_3'UTR|TP63_ENST00000456148.1_Missense_Mutation_p.N564S|TP63_ENST00000382063.4_Missense_Mutation_p.N577S|TP63_ENST00000440651.2_Missense_Mutation_p.N658S	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	662	Transactivation inhibition.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		AATGACTTCAACTTTGACATG	0.552000										HNSCC(45;0.13)			20	41					0	0	1	0	0
DNER	92737	broad.mit.edu	37	2	230377581	230377581	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:230377581C>T	ENST00000341772.4	-	6	1199	c.1065G>A	c.(1063-1065)agG>agA	p.R355R		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	355	EGF-like 4.				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		GGCAAGGTTTCCTCTGGCAAG	0.438000													24	11					0	0	1	0	0
MIIP	60672	broad.mit.edu	37	1	12082318	12082318	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:12082318C>T	ENST00000235332.4	+	3	450	c.281C>T	c.(280-282)tCt>tTt	p.S94F	MIIP_ENST00000466860.1_3'UTR|MIIP_ENST00000436478.2_Missense_Mutation_p.S94F	NM_021933.3	NP_068752.2	Q5JXC2	MIIP_HUMAN	migration and invasion inhibitory protein	94										autonomic_ganglia(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(1)	15						GGGGTGGCCTCTCTCCCACCT	0.692000													39	47					0	0	1	0	0
L3MBTL4	91133	broad.mit.edu	37	18	6243377	6243377	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:6243377C>T	ENST00000400104.3	-	7	576	c.376G>A	c.(376-378)Gat>Aat	p.D126N	L3MBTL4_ENST00000317931.7_Missense_Mutation_p.D126N|L3MBTL4_ENST00000284898.6_Missense_Mutation_p.D126N|L3MBTL4_ENST00000400105.2_Missense_Mutation_p.D126N			Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4 (Drosophila)	126					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(17)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39		Colorectal(10;0.0249)				GTCCAAAAATCATAGCAACTT	0.388000													10	31					0	0	1	0	0
WDR49	151790	broad.mit.edu	37	3	167272452	167272452	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:167272452C>T	ENST00000453925.2	-	6	979	c.945G>A	c.(943-945)tgG>tgA	p.W315*	WDR49_ENST00000308378.3_Intron|WDR49_ENST00000479765.1_Intron|WDR49_ENST00000476376.1_Intron			Q8IV35	WDR49_HUMAN	WD repeat domain 49	255										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						CTATAGTTTTCCATGAGGCAT	0.323000													18	23					0	0	1	0	0
FCRL4	83417	broad.mit.edu	37	1	157548298	157548298	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:157548298C>T	ENST00000271532.1	-	10	1530	c.1395G>A	c.(1393-1395)gaG>gaA	p.E465E	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	465						integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				TAGTCTGGATCTCAGAGTATA	0.408000													13	22					0	0	1	0	0
TTLL6	284076	broad.mit.edu	37	17	46847179	46847179	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:46847179G>A	ENST00000393382.3	-	14	2462	c.2321C>T	c.(2320-2322)tCc>tTc	p.S774F	TTLL6_ENST00000433608.2_Missense_Mutation_p.S467F	NM_001130918.1	NP_001124390.1	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	726						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity			endometrium(1)|large_intestine(5)|lung(9)|prostate(1)|skin(2)	18						GAGTAGCTCGGATATCAAATG	0.473000													15	44					0	0	1	0	0
LILRB2	10288	broad.mit.edu	37	19	54780263	54780263	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:54780263C>T	ENST00000391748.1	-	11	1655	c.1528G>A	c.(1528-1530)Gag>Aag	p.E510K	LILRB2_ENST00000434421.1_Missense_Mutation_p.E395K|LILRB2_ENST00000391746.1_Intron|LILRB2_ENST00000314446.5_Missense_Mutation_p.E510K|LILRB2_ENST00000391749.4_Missense_Mutation_p.E511K	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	511					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCTGTGGGCTCTGGCCCCACA	0.617000													14	36					0	0	1	0	0
ADAM11	4185	broad.mit.edu	37	17	42850638	42850638	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:42850638G>A	ENST00000200557.6	+	11	1004	c.835G>A	c.(835-837)Gag>Aag	p.E279K	ADAM11_ENST00000535346.1_Missense_Mutation_p.E79K	NM_002390.4	NP_002381.2	O75078	ADA11_HUMAN	ADAM metallopeptidase domain 11	279	Peptidase M12B.				integrin-mediated signaling pathway|proteolysis	integral to membrane|plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33		Prostate(33;0.0959)				GATATACAAGGAGCAGCTCAA	0.612000													36	48					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55538195	55538195	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:55538195G>A	ENST00000220676.1	+	4	1901	c.1753G>A	c.(1753-1755)Gta>Ata	p.V585I		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	585					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGATTGTGTGGTATTGGACAA	0.343000													21	34					0	0	1	0	0
CXorf58	254158	broad.mit.edu	37	X	23934380	23934380	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:23934380C>T	ENST00000379211.3	+	5	907	c.358C>T	c.(358-360)Ctt>Ttt	p.L120F		NM_001169574.1|NM_152761.2	NP_001163045.1|NP_689974.2	Q96LI9	CX058_HUMAN	chromosome X open reading frame 58	120										breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)	14						TAAAATTTTTCTTCATACTGA	0.323000													7	17					0	0	1	0	0
SPTB	6710	broad.mit.edu	37	14	65246585	65246585	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:65246585G>A	ENST00000389722.3	-	20	4384	c.4331C>T	c.(4330-4332)tCa>tTa	p.S1444L	SPTB_ENST00000556626.1_Missense_Mutation_p.S1444L|SPTB_ENST00000389720.3_Missense_Mutation_p.S1444L|SPTB_ENST00000542895.1_Missense_Mutation_p.S1444L|SPTB_ENST00000389721.5_Missense_Mutation_p.S1444L	NM_001024858.2	NP_001020029.1	P11277	SPTB1_HUMAN	spectrin, beta, erythrocytic	1444					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(36)|ovary(8)|pancreas(1)|prostate(4)|skin(10)|urinary_tract(3)	106		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CTCTCCCATTGAAGGCACCTG	0.577000													58	85					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140481403	140481403	+	Missense_Mutation	SNP	C	C	T	rs121913358		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:140481403C>T	ENST00000288602.6	-	11	1465	c.1405G>A	c.(1405-1407)Gga>Aga	p.G469R		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	469	Protein kinase.		G -> A (in NHL; also in a lung adenocarcinoma sample; somatic mutation; elevated kinase activity; efficiently induces cell transformation).|G -> E (in CFC syndrome and colon cancer).|G -> R (in NHL).|G -> V (in a colorectal adenocarcinoma sample; somatic mutation).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.G469R(6)|p.G469S(5)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TAGACTGTTCCAAATGATCCA	0.373000		61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				24	46					0	0	1	0	0
DIP2C	22982	broad.mit.edu	37	10	430503	430503	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:430503T>A	ENST00000280886.6	-	15	1826	c.1739A>T	c.(1738-1740)aAg>aTg	p.K580M	DIP2C_ENST00000381496.3_Missense_Mutation_p.K473M	NM_014974.2	NP_055789.1	Q9Y2E4	DIP2C_HUMAN	DIP2 disco-interacting protein 2 homolog C (Drosophila)	580						nucleus	catalytic activity|transcription factor binding			breast(8)|endometrium(6)|kidney(10)|large_intestine(13)|lung(26)|ovary(3)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	81		all_cancers(4;0.00336)|all_lung(4;0.00732)|Lung NSC(4;0.00785)|all_epithelial(10;0.0159)|Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.136)	Epithelial(11;0.0123)|all cancers(11;0.0467)|Lung(33;0.0864)|OV - Ovarian serous cystadenocarcinoma(14;0.106)		CTGGCAGACCTTCTGGATCCA	0.552000													28	16					0	0	1	0	0
PDXDC1	23042	broad.mit.edu	37	16	15098188	15098188	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:15098188C>T	ENST00000396410.4	+	5	484	c.387C>T	c.(385-387)ttC>ttT	p.F129F	PDXDC1_ENST00000569715.1_Silent_p.F102F|PDXDC1_ENST00000450288.2_Silent_p.F101F|PDXDC1_ENST00000325823.7_Silent_p.F114F|PDXDC1_ENST00000535621.2_Silent_p.F129F|PDXDC1_ENST00000563679.1_Silent_p.F147F|PDXDC1_ENST00000447912.2_Intron|PDXDC1_ENST00000455313.2_Silent_p.F129F	NM_015027.2	NP_055842.2	Q6P996	PDXD1_HUMAN	pyridoxal-dependent decarboxylase domain containing 1	129					carboxylic acid metabolic process		carboxy-lyase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(2)|liver(1)|lung(10)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					Pyridoxal Phosphate(DB00114)	GCAGAATTTTCAGGTAAAGAC	0.388000													19	81					0	0	1	0	0
GRIK5	2901	broad.mit.edu	37	19	42566782	42566782	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:42566782G>A	ENST00000262895.3	-	4	365	c.366C>T	c.(364-366)ccC>ccT	p.P122P	GRIK5_ENST00000593562.1_Silent_p.P122P|GRIK5_ENST00000301218.4_Silent_p.P122P	NM_002088.4	NP_002079.3	Q16478	GRIK5_HUMAN	glutamate receptor, ionotropic, kainate 5	122						cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(11)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	35		Prostate(69;0.059)			L-Glutamic Acid(DB00142)	GTGTCTCCTCGGGACCCACCT	0.622000													27	47					0	0	1	0	0
PLCB4	5332	broad.mit.edu	37	20	9400510	9400510	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:9400510C>T	ENST00000378501.2	+	22	2087	c.2072C>T	c.(2071-2073)tCt>tTt	p.S691F	PLCB4_ENST00000334005.3_Missense_Mutation_p.S691F|PLCB4_ENST00000278655.4_Missense_Mutation_p.S691F|PLCB4_ENST00000378493.1_Missense_Mutation_p.S691F|PLCB4_ENST00000414679.2_Missense_Mutation_p.S703F|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000378473.3_Missense_Mutation_p.S703F	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	691	C2.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						GACCCCTTCTCTGAAACTCCT	0.438000													31	53					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70332338	70332338	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:70332338C>T	ENST00000338508.4	-	32	4062	c.4063G>A	c.(4063-4065)Gaa>Aaa	p.E1355K	SHANK2_ENST00000423696.2_Missense_Mutation_p.E975K|SHANK2_ENST00000449833.2_Missense_Mutation_p.E759K|SHANK2_ENST00000409161.1_Missense_Mutation_p.E758K			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	975					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			CCTTCGGTTTCGGAAACACCT	0.617000													15	25					0	0	1	0	0
YLPM1	56252	broad.mit.edu	37	14	75248484	75248484	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:75248484C>T	ENST00000325680.7	+	4	1862	c.1738C>T	c.(1738-1740)Cct>Tct	p.P580S	YLPM1_ENST00000552421.1_Missense_Mutation_p.P580S|YLPM1_ENST00000238571.3_Intron	NM_019589.2	NP_062535.2	P49750	YLPM1_HUMAN	YLP motif containing 1	381					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				breast(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(12)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	62			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AGGGATGCCTCCTTCTCTCTC	0.612000													83	100					0	0	1	0	0
SNRPB	6628	broad.mit.edu	37	20	2446398	2446398	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:2446398C>T	ENST00000381342.2	-	3	385	c.223G>A	c.(223-225)Gag>Aag	p.E75K	SNRPB_ENST00000438552.2_Missense_Mutation_p.E75K|SNRPB_ENST00000339610.6_5'UTR	NM_003091.3	NP_003082.1	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptides B and B1	75					histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	10						ACCAGATTCTCCCCTCGCAGC	0.522000													28	27					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157959910	157959910	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:157959910G>A	ENST00000389413.3	-	6	726	c.623C>T	c.(622-624)tCc>tTc	p.S208F	PTPRN2_ENST00000389416.4_Missense_Mutation_p.S191F|PTPRN2_ENST00000409483.1_Missense_Mutation_p.S170F|PTPRN2_ENST00000404321.2_Missense_Mutation_p.S231F|PTPRN2_ENST00000389418.4_Missense_Mutation_p.S208F	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	208			S -> P (in dbSNP:rs1130495).			integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		CTGGGTCCGGGACCCGGGAGG	0.632000													24	28					0	0	1	0	0
VAV1	7409	broad.mit.edu	37	19	6820818	6820818	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:6820818G>A	ENST00000304076.2	+	2	404	c.310G>A	c.(310-312)Gat>Aat	p.D104N	VAV1_ENST00000596764.1_Missense_Mutation_p.D104N|VAV1_ENST00000539284.1_Missense_Mutation_p.D39N|VAV1_ENST00000602142.1_Missense_Mutation_p.D104N|VAV1_ENST00000599806.1_Missense_Mutation_p.D49N	NM_001258206.1	NP_001245135.1	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	104	CH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(16)|lung(18)|ovary(5)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	62						CGATGTGCAGGATTTTGGCAA	0.498000													48	60					0	0	1	0	0
SHANK1	50944	broad.mit.edu	37	19	51171752	51171752	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:51171752G>A	ENST00000293441.1	-	22	3483	c.3465C>T	c.(3463-3465)atC>atT	p.I1155I	SHANK1_ENST00000391814.1_Silent_p.I1163I|SHANK1_ENST00000391813.1_Silent_p.I542I|SHANK1_ENST00000359082.3_Silent_p.I1146I	NM_016148.2	NP_057232.2	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	1155					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	64		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		TGATGGTGGGGATGGGGATGG	0.771000													4	18					0	0	1	0	0
PASK	23178	broad.mit.edu	37	2	242079977	242079977	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:242079977G>A	ENST00000403638.3	-	3	479	c.388C>T	c.(388-390)Cct>Tct	p.P130S	PASK_ENST00000539818.1_Intron|PASK_ENST00000544142.1_Intron|PASK_ENST00000405260.1_Missense_Mutation_p.P130S|PASK_ENST00000358649.4_Missense_Mutation_p.P130S|PASK_ENST00000234040.4_Missense_Mutation_p.P130S	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	130	PAS 1.				regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GCCTTGTTAGGGTTGCACACA	0.572000													10	4					0	0	1	0	0
MYH8	4626	broad.mit.edu	37	17	10307703	10307703	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:10307703C>T	ENST00000403437.2	-	22	2726	c.2632G>A	c.(2632-2634)Gaa>Aaa	p.E878K	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	878					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						ACCATTTTTTCCTCTAGCTCC	0.433000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				16	12					0	0	1	0	0
CHRM5	1133	broad.mit.edu	37	15	34355747	34355747	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:34355747A>C	ENST00000383263.5	+	3	1499	c.829A>C	c.(829-831)Agc>Cgc	p.S277R	CHRM5_ENST00000557872.1_Missense_Mutation_p.S277R	NM_012125.3	NP_036257.1	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	277					cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	20		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	CTCCCGCAGGAGCACCTCCAC	0.627000													28	41					0	0	1	0	0
OR4D6	219983	broad.mit.edu	37	11	59225273	59225273	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:59225273C>T	ENST00000300127.2	+	1	863	c.840C>T	c.(838-840)ccC>ccT	p.P280P		NM_001004708.1	NP_001004708.1	Q8NGJ1	OR4D6_HUMAN	olfactory receptor, family 4, subfamily D, member 6	280					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	34						TCATTACCCCCATGCTGAACC	0.502000													27	56					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240341310	240341310	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:240341310C>T	ENST00000319653.9	+	3	2102	c.1872C>T	c.(1870-1872)tcC>tcT	p.S624S	RP11-567G24.3_ENST00000444308.1_RNA|RP11-567G24.3_ENST00000412311.1_RNA	NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	624					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GAGTTCCATCCATGGGGCCAC	0.473000													11	22					0	0	1	0	0
ZNF391	346157	broad.mit.edu	37	6	27369096	27369096	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:27369096G>A	ENST00000244576.4	+	3	1492	c.947G>A	c.(946-948)cGa>cAa	p.R316Q		NM_001076781.1	NP_001070249.1	Q9UJN7	ZN391_HUMAN	zinc finger protein 391	316					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R316Q(2)		endometrium(2)|large_intestine(6)|lung(7)|pancreas(2)|skin(3)|upper_aerodigestive_tract(1)	21						GGCTTCAGTCGAAGCTCATCC	0.463000													12	32					0	0	1	0	0
RASGRF2	5924	broad.mit.edu	37	5	80369246	80369246	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:80369246G>A	ENST00000265080.4	+	5	929	c.862G>A	c.(862-864)Gac>Aac	p.D288N	RASGRF2_ENST00000502677.1_3'UTR	NM_006909.2	NP_008840.1	O14827	RGRF2_HUMAN	Ras protein-specific guanine nucleotide-releasing factor 2	288	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|endoplasmic reticulum membrane|plasma membrane	protein binding|Rho guanyl-nucleotide exchange factor activity			biliary_tract(1)|breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(28)|ovary(5)|prostate(3)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	75		Lung NSC(167;0.00498)|all_lung(232;0.00531)|Ovarian(174;0.0357)		OV - Ovarian serous cystadenocarcinoma(54;4.22e-42)|Epithelial(54;4.04e-35)|all cancers(79;2.52e-29)		CAGCCACGACGACGTCAGCAG	0.453000													11	20					0	0	1	0	0
OR4C16	219428	broad.mit.edu	37	11	55340152	55340152	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:55340152G>A	ENST00000314634.3	+	1	549	c.549G>A	c.(547-549)ttG>ttA	p.L183L		NM_001004701.2	NP_001004701.2	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C, member 16 (gene/pseudogene)	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(28)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41		all_epithelial(135;0.0748)				AGCCCTTGTTGAAACAAGCCT	0.438000													28	46					0	0	1	0	0
TMC2	117532	broad.mit.edu	37	20	2591196	2591196	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:2591196G>A	ENST00000358864.1	+	12	1560	c.1545G>A	c.(1543-1545)ggG>ggA	p.G515G	TMC2_ENST00000496948.1_3'UTR	NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	515						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						TCTTCCTGGGGAACCTCTACA	0.537000													15	21					0	0	1	0	0
GZMH	2999	broad.mit.edu	37	14	25078796	25078796	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:25078796C>T	ENST00000216338.4	-	1	68	c.24G>A	c.(22-24)ttG>ttA	p.L8L	RP11-104E19.1_ENST00000557736.1_RNA|GZMH_ENST00000557220.2_Silent_p.L8L|RP11-104E19.1_ENST00000555300.1_RNA|GZMH_ENST00000382548.4_Silent_p.L8L	NM_033423.3	NP_219491.1	P20718	GRAH_HUMAN	granzyme H (cathepsin G-like 2, protein h-CCPX)	8					apoptosis|cytolysis|proteolysis	cytoplasm	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)	12				GBM - Glioblastoma multiforme(265;0.0267)		GAAGAAAGGCCAACAGGAGGA	0.527000													14	42					0	0	1	0	0
CELSR1	9620	broad.mit.edu	37	22	46930300	46930300	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:46930300G>A	ENST00000262738.3	-	1	2767	c.2768C>T	c.(2767-2769)cCc>cTc	p.P923L	CELSR1_ENST00000395964.1_Missense_Mutation_p.P923L	NM_014246.1	NP_055061.1	Q9NYQ6	CELR1_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 1	923	Cadherin 7.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			breast(8)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(13)|lung(27)|ovary(2)|pancreas(2)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	95		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		ACGCCCATTGGGACCTGAGTC	0.627000													11	37					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117749276	117749276	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:117749276C>T	ENST00000317775.6	-	3	1532	c.847G>A	c.(847-849)Gag>Aag	p.E283K	NOS1_ENST00000344089.3_Missense_Mutation_p.E283K|NOS1_ENST00000338101.4_Missense_Mutation_p.E283K	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	283					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CTTACCTGCTCCTTCTCTGAA	0.562000													7	5					0	0	1	0	0
MAGEB3	4114	broad.mit.edu	37	X	30254048	30254048	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:30254048C>T	ENST00000361644.2	+	5	744	c.7C>T	c.(7-9)Cgg>Tgg	p.R3W	MAGEB3_ENST00000378986.1_Missense_Mutation_p.R3W	NM_002365.4	NP_002356.2	O15480	MAGB3_HUMAN	melanoma antigen family B, 3	3										NS(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|prostate(2)|skin(2)	25						CATCATGCCTCGGGGTCAGAA	0.562000													11	18					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28358283	28358283	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:28358283G>A	ENST00000261609.7	-	92	14274	c.14166C>T	c.(14164-14166)ttC>ttT	p.F4722F		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	4722	HECT.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GGCCCCAGACGAAGCGAAGGA	0.627000													16	22					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41719783	41719783	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr21:41719783C>T	ENST00000400454.1	-	6	1501	c.1024G>A	c.(1024-1026)Gac>Aac	p.D342N		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	342	Ig-like C2-type 4.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				AGTTCCTGGTCCTCAGTTCCT	0.493000													42	18					0	0	1	0	0
IGHV3-43	28426	broad.mit.edu	37	14	106926469	106926469	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:106926469C>T	ENST00000434710.1	-	0	152																											CCCCCAGACTCCACCAGCTGC	0.542000													19	91					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228548368	228548368	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:228548368C>T	ENST00000284548.11	+	81	19849	c.19775C>T	c.(19774-19776)aCc>aTc	p.T6592I	OBSCN_ENST00000422127.1_Intron|OBSCN_ENST00000570156.2_Intron|OBSCN_ENST00000366707.4_Intron|OBSCN_ENST00000366709.4_Missense_Mutation_p.T3711I			Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GAGCTTTCCACCCAGACCGTC	0.637000													6	11					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240286642	240286642	+	Silent	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:240286642T>C	ENST00000319653.9	+	2	2009	c.1779T>C	c.(1777-1779)ttT>ttC	p.F593F		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	593					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CAGCTTCGTTTGATGTAAGTA	0.448000													15	23					0	0	1	0	0
PLEKHG2	64857	broad.mit.edu	37	19	39907626	39907626	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:39907626C>T	ENST00000425673.1	+	7	1055	c.730C>T	c.(730-732)Cat>Tat	p.H244Y	PLEKHG2_ENST00000458508.2_Missense_Mutation_p.H185Y|PLEKHG2_ENST00000409794.3_Missense_Mutation_p.H244Y|PLEKHG2_ENST00000409797.2_Missense_Mutation_p.H244Y|PLEKHG2_ENST00000378550.1_Missense_Mutation_p.H244Y			Q9H7P9	PKHG2_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 2	244	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(2)|liver(1)|lung(13)|pancreas(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	40	all_cancers(60;3.08e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;6.57e-07)|Ovarian(47;0.0569)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TCTCAAGTACCATCTGCTGCT	0.657000													20	37					0	0	1	0	0
ALDH2	217	broad.mit.edu	37	12	112241749	112241749	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:112241749G>A	ENST00000261733.2	+	12	1554	c.1493G>A	c.(1492-1494)gGg>gAg	p.G498E	ALDH2_ENST00000416293.3_Missense_Mutation_p.G451E	NM_000690.3	NP_000681.2	P05091	ALDH2_HUMAN	aldehyde dehydrogenase 2 family (mitochondrial)	498					carbohydrate metabolic process|ethanol oxidation|neurotransmitter biosynthetic process|xenobiotic metabolic process	mitochondrial matrix	aldehyde dehydrogenase|aldehyde dehydrogenase (NAD) activity|electron carrier activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(6)|ovary(2)|prostate(1)|skin(2)|stomach(1)	22					Disulfiram(DB00822)|Guanidine(DB00536)|NADH(DB00157)|Nitroglycerin(DB00727)	GGCGAGTACGGGCTGCAGGCA	0.582000			T	HMGA2	leiomyoma								3	8					0	0	1	0	0
MAP3K19	80122	broad.mit.edu	37	2	135738522	135738522	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:135738522C>T	ENST00000375845.3	-	9	3819	c.3789G>A	c.(3787-3789)ggG>ggA	p.G1263G	MAP3K19_ENST00000392918.3_Silent_p.G397G|MAP3K19_ENST00000392917.3_Silent_p.G395G|MAP3K19_ENST00000375844.3_Silent_p.G445G|MAP3K19_ENST00000392915.1_3'UTR|MAP3K19_ENST00000315513.3_Silent_p.G124G|MAP3K19_ENST00000358371.4_Silent_p.G1150G	NM_025052.3	NP_079328.3			mitogen-activated protein kinase kinase kinase 19																		GTGGAGGCTTCCCTGTAGCCA	0.507000													14	9					0	0	1	0	0
SPOCD1	90853	broad.mit.edu	37	1	32280509	32280509	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:32280509G>A	ENST00000360482.2	-	2	555	c.426C>T	c.(424-426)ctC>ctT	p.L142L	SPOCD1_ENST00000373648.2_Silent_p.L142L|SPOCD1_ENST00000533231.1_Silent_p.L142L|SPOCD1_ENST00000257100.3_Intron	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	142					transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		CTCTCTCTGGGAGGCCAGCAG	0.592000													34	67					0	0	1	0	0
IL21R	50615	broad.mit.edu	37	16	27455915	27455915	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:27455915C>T	ENST00000337929.3	+	6	1033	c.560C>T	c.(559-561)cCc>cTc	p.P187L	IL21R_ENST00000395754.4_Missense_Mutation_p.P187L|IL21R_ENST00000564583.1_3'UTR|IL21R_ENST00000395755.1_Missense_Mutation_p.P187L|IL21R_ENST00000564089.1_Missense_Mutation_p.P187L	NM_181078.2	NP_851564.1	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor	187	Fibronectin type-III.				natural killer cell activation	integral to membrane	interleukin-21 receptor activity	p.P187L(2)		breast(2)|large_intestine(3)|lung(1)|ovary(2)	8						TCCCTCCTCCCCCTGGAGTTC	0.592000			T	BCL6	NHL								22	25					0	0	1	0	0
SH2D1A	4068	broad.mit.edu	37	X	123505236	123505236	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:123505236C>T	ENST00000371139.4	+	4	681	c.382C>T	c.(382-384)Cca>Tca	p.P128S	STAG2_ENST00000469481.1_Intron|SH2D1A_ENST00000470647.1_3'UTR|SH2D1A_ENST00000360027.4_Missense_Mutation_p.P125S	NM_001114937.2|NM_002351.4	NP_001108409.1|NP_002342.1	O60880	SH21A_HUMAN	SH2 domain containing 1A	128					cell-cell signaling|cellular defense response	cytoplasm	SH3/SH2 adaptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	10						CCTGAAAGCCCCATGAAGAAA	0.269000													8	13					0	0	1	0	0
MAPK8IP1	9479	broad.mit.edu	37	11	45919679	45919679	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:45919679C>T	ENST00000395629.2	+	2	445	c.115C>T	c.(115-117)Ctc>Ttc	p.L39F	MAPK8IP1_ENST00000241014.2_Missense_Mutation_p.L49F			Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting protein 1	49					vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(2)	24				GBM - Glioblastoma multiforme(35;0.231)		GGATGAAGACCTCTCGGAGAT	0.557000													7	14					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371221	240371221	+	Missense_Mutation	SNP	C	C	T	rs71297737		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:240371221C>T	ENST00000319653.9	+	5	3339	c.3109C>T	c.(3109-3111)Ccc>Tcc	p.P1037S		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1037	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding	p.P1180S(1)		NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCCCCCACTTCCCGGAGCGGG	0.726000													12	23					0	0	1	0	0
FRY	10129	broad.mit.edu	37	13	32799128	32799128	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:32799128G>A	ENST00000380250.3	+	38	5471	c.4975G>A	c.(4975-4977)Gac>Aac	p.D1659N		NM_023037.2	NP_075463.2	Q5TBA9	FRY_HUMAN	furry homolog (Drosophila)	1659					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				NS(3)|breast(4)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(31)|lung(50)|ovary(5)|pancreas(1)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	132		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TGTACGAGAAGACTGGGCGCT	0.373000													20	62					0	0	1	0	0
CILP	8483	broad.mit.edu	37	15	65502077	65502077	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:65502077G>A	ENST00000261883.4	-	2	183	c.17C>T	c.(16-18)gCc>gTc	p.A6V		NM_003613.3	NP_003604.3	O75339	CILP1_HUMAN	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	6					negative regulation of insulin-like growth factor receptor signaling pathway	extracellular matrix part|extracellular space|proteinaceous extracellular matrix				breast(5)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(17)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(1)	55						GAACACCCAGGCCTTGGTCCC	0.557000													16	23					0	0	1	0	0
USP4	7375	broad.mit.edu	37	3	49323652	49323652	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:49323652G>A	ENST00000351842.4	-	15	1946	c.1938C>T	c.(1936-1938)acC>acT	p.T646T	USP4_ENST00000265560.4_Silent_p.T693T	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	693					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		TCTTCTTTTGGGTGGTCTCAC	0.473000													21	30					0	0	1	0	0
RTEL1	51750	broad.mit.edu	37	20	62328307	62328307	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:62328307C>T	ENST00000318100.4	+	36	4921	c.4094C>T	c.(4093-4095)cCg>cTg	p.P1365L	RTEL1-TNFRSF6B_ENST00000482936.1_Missense_Mutation_p.P1365L|TNFRSF6B_ENST00000369996.1_Missense_Mutation_p.R63C			Q9NZ71	RTEL1_HUMAN	regulator of telomere elongation helicase 1	0					DNA repair|regulation of double-strand break repair via homologous recombination|telomere maintenance	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(38;6.47e-12)|all_epithelial(29;3.75e-13)		Epithelial(9;1.25e-09)|all cancers(9;5.13e-09)|BRCA - Breast invasive adenocarcinoma(10;7.26e-05)|OV - Ovarian serous cystadenocarcinoma(5;0.00223)|Colorectal(105;0.107)			GCGGCCGTGCCGCCGAGACAG	0.682000													8	9					0	0	1	0	0
MGLL	11343	broad.mit.edu	37	3	127439949	127439949	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:127439949C>T	ENST00000434178.2	-	5	1323	c.427G>A	c.(427-429)Gta>Ata	p.V143I	MGLL_ENST00000265052.5_Missense_Mutation_p.V153I|MGLL_ENST00000453507.2_Missense_Mutation_p.V153I|MGLL_ENST00000398104.1_Missense_Mutation_p.V143I|MGLL_ENST00000398101.3_Missense_Mutation_p.V117I			Q99685	MGLL_HUMAN	monoglyceride lipase	143					arachidonic acid metabolic process|fatty acid biosynthetic process|inflammatory response|platelet activation|regulation of endocannabinoid signaling pathway|regulation of inflammatory response|regulation of sensory perception of pain|triglyceride catabolic process	plasma membrane	acylglycerol lipase activity|carboxylesterase activity|lysophospholipase activity|protein homodimerization activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)	6						GAAATGAGTACCATGCCGGCG	0.567000													14	33					0	0	1	0	0
IGKV1D-8	28904	broad.mit.edu	37	2	90259782	90259782	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:90259782G>A	ENST00000471857.1	+	0	190																											GCATGGACATGAGGGTCCCCG	0.547000													42	20					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23775180	23775180	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:23775180G>A	ENST00000354639.3	+	7	902	c.438G>A	c.(436-438)ttG>ttA	p.L146L	STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Silent_p.L146L|STK31_ENST00000433467.2_Silent_p.L169L|STK31_ENST00000355870.3_Silent_p.L169L	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	169							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						TGGGGAGCTTGATTTTTGAAA	0.388000													23	28					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4513345	4513345	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:4513345G>A	ENST00000301286.3	-	3	584	c.585C>T	c.(583-585)gtC>gtT	p.V195V		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	195	27 X 33 AA approximate tandem repeat.					lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						CTGCCCCCATGACCCCAGTAG	0.597000													47	66					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21695476	21695476	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:21695476C>T	ENST00000328843.6	+	29	5017	c.4986C>T	c.(4984-4986)ttC>ttT	p.F1662F	DNAH11_ENST00000409508.3_Silent_p.F1657F			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1662	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CCAAACTTTTCGACAGCATTG	0.383000									Kartagener syndrome				7	16					0	0	1	0	0
DOT1L	84444	broad.mit.edu	37	19	2222198	2222198	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:2222198C>T	ENST00000398665.3	+	24	3066	c.3030C>T	c.(3028-3030)ccC>ccT	p.P1010P		NM_032482.2	NP_115871.1	Q8TEK3	DOT1L_HUMAN	DOT1-like histone H3K79 methyltransferase	1010						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(2)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(9)	42		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTCCAGTCCCCGGCTTGGTG	0.697000													16	44					0	0	1	0	0
CNBD1	168975	broad.mit.edu	37	8	88365919	88365919	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:88365919G>A	ENST00000518476.1	+	10	1259	c.1208G>A	c.(1207-1209)gGt>gAt	p.G403D		NM_173538.2	NP_775809.1	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	403										breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(16)|ovary(4)|urinary_tract(1)	32						GAGTCCTTTGGTGAGATTAGC	0.338000													8	13					0	0	1	0	0
CDH5	1003	broad.mit.edu	37	16	66436860	66436860	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:66436860G>A	ENST00000341529.3	+	12	2291	c.2143G>A	c.(2143-2145)Gag>Aag	p.E715K	CDH5_ENST00000539168.1_Missense_Mutation_p.E154K	NM_001795.3	NP_001786.2	P33151	CADH5_HUMAN	cadherin 5, type 2 (vascular endothelium)	715					adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(18)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		GAAGAAGGACGAGGCGGACCA	0.682000													8	17					0	0	1	0	0
CNGA4	1262	broad.mit.edu	37	11	6265382	6265382	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:6265382G>A	ENST00000379936.2	+	6	1586	c.1471G>A	c.(1471-1473)Gag>Aag	p.E491K		NM_001037329.3	NP_001032406.1	Q8IV77	CNGA4_HUMAN	cyclic nucleotide gated channel alpha 4	491					response to stimulus|sensory perception of smell		cAMP binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(24)|prostate(3)|skin(1)	40		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.04e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CGCCCTGCAGGAGGCCACAGA	0.557000													13	25					0	0	1	0	0
GIPR	2696	broad.mit.edu	37	19	46180604	46180604	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:46180604C>T	ENST00000590918.1	+	9	916	c.817C>T	c.(817-819)Ccc>Tcc	p.P273S	GIPR_ENST00000304207.8_Missense_Mutation_p.P237S|GIPR_ENST00000263281.3_Missense_Mutation_p.P273S	NM_000164.2	NP_000155.1	P48546	GIPR_HUMAN	gastric inhibitory polypeptide receptor	273					generation of precursor metabolites and energy|response to nutrient	integral to membrane|plasma membrane				endometrium(1)|kidney(2)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	12		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0056)|GBM - Glioblastoma multiforme(486;0.0832)|Epithelial(262;0.199)		TTTCGTCATTCCCTGGGTGAT	0.716000													4	13					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38820470	38820470	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:38820470C>T	ENST00000359357.3	+	38	5070	c.4815_splice	c.e38-1	p.P1606_splice	DNAH8_ENST00000449981.2_Splice_Site_p.P1823_splice|DNAH8_ENST00000441566.1_Splice_Site_p.P1606_splice					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TGTCTTACAGCCGCATCTCCC	0.393000													13	31					0	0	1	0	0
GIPC3	126326	broad.mit.edu	37	19	3589521	3589521	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:3589521C>T	ENST00000322315.5	+	4	718	c.673C>T	c.(673-675)Cgt>Tgt	p.R225C		NM_133261.2	NP_573568.1	Q8TF64	GIPC3_HUMAN	GIPC PDZ domain containing family, member 3	225										breast(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	10				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0025)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGCGGCTTCGTTCTGGGGG	0.612000													16	32					0	0	1	0	0
TNFRSF18	8784	broad.mit.edu	37	1	1140777	1140777	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:1140777G>A	ENST00000379268.2	-	2	402	c.283C>T	c.(283-285)Ccc>Tcc	p.P95S	TNFRSF18_ENST00000379265.5_Missense_Mutation_p.P95S|TNFRSF18_ENST00000328596.6_Missense_Mutation_p.P95S|TNFRSF18_ENST00000486728.1_Missense_Mutation_p.P23S	NM_004195.2|NM_148902.1	NP_004186.1|NP_683700.1	Q9Y5U5	TNR18_HUMAN	tumor necrosis factor receptor superfamily, member 18	95					anti-apoptosis|apoptosis	extracellular region|integral to plasma membrane	tumor necrosis factor receptor activity			lung(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		TGGCCTGGGGGACAAGGGTGG	0.657000													11	9					0	0	1	0	0
TTC3	7267	broad.mit.edu	37	21	38462568	38462568	+	Silent	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr21:38462568T>C	ENST00000399017.2	+	6	3209	c.462T>C	c.(460-462)atT>atC	p.I154I	TTC3_ENST00000540756.1_Intron|TTC3_ENST00000399010.1_Silent_p.I154I|TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000355666.1_Silent_p.I154I|TTC3_ENST00000354749.2_Silent_p.I154I	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	154					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				TATTGAGAATTGGTTGTAAAA	0.358000													7	6					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152127548	152127548	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:152127548C>T	ENST00000316073.3	-	3	2091	c.2027G>A	c.(2026-2028)gGg>gAg	p.G676E		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	676	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						CCAGTCTCTCCCTTTGTGACA	0.542000													51	67					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91090714	91090714	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:91090714G>A	ENST00000373094.1	+	1	1056	c.211G>A	c.(211-213)Gat>Aat	p.D71N	PCDH11X_ENST00000298274.8_Missense_Mutation_p.D71N|PCDH11X_ENST00000373088.1_Missense_Mutation_p.D71N|PCDH11X_ENST00000395337.2_Missense_Mutation_p.D71N|PCDH11X_ENST00000504220.1_Missense_Mutation_p.D71N|PCDH11X_ENST00000406881.1_Missense_Mutation_p.D71N|PCDH11X_ENST00000361724.1_Missense_Mutation_p.D71N|PCDH11X_ENST00000361655.2_Missense_Mutation_p.D71N|PCDH11X_ENST00000373097.1_Missense_Mutation_p.D71N	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	71	Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						CAAGACCGGAGATGTGCCACT	0.463000													24	55					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54872617	54872617	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:54872617G>A	ENST00000474759.1	+	16	1541	c.1493G>A	c.(1492-1494)gGa>gAa	p.G498E	CACNA2D3_ENST00000288197.5_Missense_Mutation_p.G498E|CACNA2D3_ENST00000490478.1_Missense_Mutation_p.G404E|CACNA2D3_ENST00000415676.2_Missense_Mutation_p.G498E	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	498	Cache.					integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		ATTCTTCTGGGAGTGGTTGGC	0.388000													31	46					0	0	1	0	0
DCP2	167227	broad.mit.edu	37	5	112337084	112337084	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:112337084C>T	ENST00000389063.2	+	6	814	c.616C>T	c.(616-618)Cct>Tct	p.P206S	DCP2_ENST00000543319.1_5'UTR|DCP2_ENST00000515408.1_Missense_Mutation_p.P206S	NM_152624.5	NP_689837.2	Q8IU60	DCP2_HUMAN	decapping mRNA 2	206	Nudix hydrolase.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|RNA binding			endometrium(3)|large_intestine(6)|lung(1)	10		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)		TGAGAAATTGCCTTGTCATAG	0.333000													15	36					0	0	1	0	0
TMLHE	55217	broad.mit.edu	37	X	154736692	154736692	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:154736692C>T	ENST00000334398.3	-	6	1007	c.862G>A	c.(862-864)Gaa>Aaa	p.E288K	TMLHE-AS1_ENST00000452506.1_RNA|TMLHE_ENST00000369439.4_Missense_Mutation_p.E288K	NM_018196.3	NP_060666.1	Q9NVH6	TMLH_HUMAN	trimethyllysine hydroxylase, epsilon	288					carnitine biosynthetic process	mitochondrial matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|trimethyllysine dioxygenase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Succinic acid(DB00139)|Vitamin C(DB00126)	AGTTCAAATTCCTCAGGTGCC	0.408000													39	63					0	0	1	0	0
RGS9	8787	broad.mit.edu	37	17	63173899	63173899	+	Missense_Mutation	SNP	C	C	T	rs145263061		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:63173899C>T	ENST00000449996.3	+	9	704	c.632C>T	c.(631-633)cCg>cTg	p.P211L	RGS9_ENST00000443584.3_Missense_Mutation_p.P211L|RGS9_ENST00000262406.9_Missense_Mutation_p.P211L|RGS9_ENST00000577186.1_3'UTR	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	211					intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity	p.P211L(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						GTGACCAATCCGAATGAAGTC	0.488000													31	25					0	0	1	0	0
PIPOX	51268	broad.mit.edu	37	17	27380580	27380580	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:27380580C>T	ENST00000323372.4	+	4	953	c.627C>T	c.(625-627)ctC>ctT	p.L209L	PIPOX_ENST00000583215.1_3'UTR	NM_016518.2	NP_057602.2	Q9P0Z9	SOX_HUMAN	pipecolic acid oxidase	209					tetrahydrofolate metabolic process	peroxisome	L-pipecolate oxidase activity|sarcosine oxidase activity			endometrium(2)|large_intestine(4)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	10	Lung NSC(42;0.015)		Epithelial(11;9.87e-06)|BRCA - Breast invasive adenocarcinoma(11;3.92e-05)|all cancers(11;5.59e-05)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)		Glycine(DB00145)	CCAACCAGCTCCTCCGTCCCC	0.547000													18	41					0	0	1	0	0
RFFL	117584	broad.mit.edu	37	17	33353427	33353427	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:33353427G>A	ENST00000315249.7	-	2	368	c.146C>T	c.(145-147)tCc>tTc	p.S49F	RFFL_ENST00000268850.7_Missense_Mutation_p.S49F|RFFL_ENST00000394597.2_Missense_Mutation_p.S49F|RFFL_ENST00000584655.1_Missense_Mutation_p.S49F|RFFL_ENST00000378516.2_Missense_Mutation_p.S49F|RFFL_ENST00000413582.2_Missense_Mutation_p.S49F|RAD51L3-RFFL_ENST00000593039.1_Intron|RFFL_ENST00000447669.2_Missense_Mutation_p.S49F|RFFL_ENST00000415395.2_Missense_Mutation_p.S49F			Q8WZ73	RFFL_HUMAN	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase	49					apoptosis	membrane	ligase activity|zinc ion binding			kidney(1)|large_intestine(2)|lung(3)	6		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		AGCCCCACAGGACTTGCAGCT	0.607000													13	17					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176525597	176525597	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:176525597G>A	ENST00000367662.3	+	2	1303	c.139G>A	c.(139-141)Gga>Aga	p.G47R	PAPPA2_ENST00000367661.3_Missense_Mutation_p.G47R	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	47					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GCTGTTGGAAGGAGAACGTTG	0.557000													33	34					0	0	1	0	0
BMP2K	55589	broad.mit.edu	37	4	79786768	79786768	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:79786768G>A	ENST00000335016.5	+	10	1291	c.1125G>A	c.(1123-1125)aaG>aaA	p.K375K	BMP2K_ENST00000502871.1_Silent_p.K375K	NM_198892.1	NP_942595.1	Q9NSY1	BMP2K_HUMAN	BMP2 inducible kinase	375						nucleus	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	13						AAAGACCAAAGGCCAACTCTG	0.413000													25	30					0	0	1	0	0
TH	7054	broad.mit.edu	37	11	2186473	2186473	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:2186473C>T	ENST00000381178.1	-	13	1434	c.1416G>A	c.(1414-1416)aaG>aaA	p.K472K	TH_ENST00000381175.1_Silent_p.K468K|TH_ENST00000333684.5_Silent_p.K351K|TH_ENST00000352909.3_Silent_p.K441K	NM_199292.2	NP_954986.2	P07101	TY3H_HUMAN	tyrosine hydroxylase	472					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity			NS(1)|endometrium(1)|large_intestine(1)|lung(7)|skin(1)	11		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	TGAGCTTGTCCTTGGCGTCAC	0.627000													27	44					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156786131	156786131	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:156786131A>T	ENST00000347377.6	+	24	3223	c.2792A>T	c.(2791-2793)gAa>gTa	p.E931V	CYFIP2_ENST00000442283.2_Missense_Mutation_p.N215Y|CYFIP2_ENST00000541131.1_Missense_Mutation_p.E856V|CYFIP2_ENST00000435847.2_Missense_Mutation_p.E630V|CYFIP2_ENST00000377576.3_Missense_Mutation_p.E931V|CYFIP2_ENST00000318218.6_Missense_Mutation_p.E956V|CYFIP2_ENST00000521420.1_Missense_Mutation_p.E905V|CYFIP2_ENST00000522463.1_Missense_Mutation_p.E735V	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	956					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTCATGGAGGAACTGCTAAAG	0.463000													26	39					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600664	29600664	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:29600664C>T	ENST00000431530.3	+	1	1917	c.1859C>T	c.(1858-1860)tCc>tTc	p.S620F		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	610						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GACACACCTTCCTCGCAGGAG	0.522000													18	15					0	0	1	0	0
CCNT2	905	broad.mit.edu	37	2	135677382	135677382	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:135677382C>T	ENST00000264157.5	+	2	191	c.161C>T	c.(160-162)tCt>tTt	p.S54F	CCNT2_ENST00000537343.1_5'UTR|CCNT2_ENST00000295238.6_Missense_Mutation_p.S54F	NM_001241.3|NM_058241.2	NP_001232.1|NP_490595.1	O60583	CCNT2_HUMAN	cyclin T2	54					cell cycle|cell division|interspecies interaction between organisms|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein kinase binding			endometrium(2)|kidney(3)|large_intestine(10)|lung(6)|ovary(2)|prostate(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.107)		CGTTCCAGCTCTCAGCTTACA	0.348000													16	8					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17052665	17052665	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:17052665G>A	ENST00000418129.2	+	2	1914	c.1449G>A	c.(1447-1449)gtG>gtA	p.V483V	PLCL2_ENST00000396755.2_Silent_p.V483V|PLCL2_ENST00000432376.1_Silent_p.V483V	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	609	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						ATGTGCCTGTGAAGCGATTTC	0.438000													14	22					0	0	1	0	0
KLHL25	64410	broad.mit.edu	37	15	86312345	86312345	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:86312345G>A	ENST00000337975.5	-	2	971	c.697C>T	c.(697-699)Ctc>Ttc	p.L233F	KLHL25_ENST00000559131.1_Intron|KLHL25_ENST00000536947.1_Missense_Mutation_p.L233F	NM_022480.3	NP_071925.2	Q9H0H3	ENC2_HUMAN	kelch-like family member 25	233						cytoplasm				breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	25						ACGCTGCGGAGGAGCTCGGGC	0.652000													9	16					0	0	1	0	0
TKTL1	8277	broad.mit.edu	37	X	153533723	153533723	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:153533723A>G	ENST00000369915.3	+	2	391	c.202A>G	c.(202-204)Aag>Gag	p.K68E	TKTL1_ENST00000217905.7_Missense_Mutation_p.K12E|TKTL1_ENST00000369912.2_Missense_Mutation_p.K12E	NM_001145933.1|NM_012253.3	NP_001139405.1|NP_036385.3	P51854	TKTL1_HUMAN	transketolase-like 1	68					glucose catabolic process|thiamine metabolic process	cytoplasm|nucleus	metal ion binding|transketolase activity			NS(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(5)|prostate(1)|skin(1)|urinary_tract(2)	34	all_cancers(53;5.05e-16)|all_epithelial(53;1.82e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CATGAGGTACAAGCAGTCAGA	0.522000													19	32					0	0	1	0	0
PROS1	5627	broad.mit.edu	37	3	93611825	93611825	+	Silent	SNP	G	G	A	rs138227513		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:93611825G>A	ENST00000394236.3	-	10	1423	c.1107C>T	c.(1105-1107)tcC>tcT	p.S369S	PROS1_ENST00000407433.1_Silent_p.S238S	NM_000313.3	NP_000304.2	P07225	PROS_HUMAN	protein S (alpha)	369	Laminin G-like 1.				leukocyte migration|peptidyl-glutamic acid carboxylation|platelet activation|platelet degranulation|post-translational protein modification|proteolysis	endoplasmic reticulum membrane|extracellular region|Golgi lumen|Golgi membrane|platelet alpha granule lumen	calcium ion binding|endopeptidase inhibitor activity			endometrium(3)|kidney(5)|large_intestine(8)|lung(26)|ovary(1)|skin(2)|urinary_tract(1)	46					Antihemophilic Factor(DB00025)|Drotrecogin alfa(DB00055)|Menadione(DB00170)	TTGTGATTTTGGATGTATGTT	0.398000													14	41					0	0	1	0	0
PRR19	284338	broad.mit.edu	37	19	42814737	42814737	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:42814737C>T	ENST00000499536.2	+	2	1727	c.916C>T	c.(916-918)Cct>Tct	p.P306S	PRR19_ENST00000341747.3_Missense_Mutation_p.P306S|PRR19_ENST00000598490.1_3'UTR			A6NJB7	PRR19_HUMAN	proline rich 19	306	Pro-rich.									NS(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	10		Prostate(69;0.00682)				GGTTGGCCTCCCTCAGCCCCT	0.652000													59	76					0	0	1	0	0
TMEM47	83604	broad.mit.edu	37	X	34648488	34648488	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:34648488G>A	ENST00000275954.3	-	3	746	c.488C>T	c.(487-489)tCg>tTg	p.S163L		NM_031442.3	NP_113630.1	Q9BQJ4	TMM47_HUMAN	transmembrane protein 47	163						integral to membrane				breast(1)|kidney(1)|large_intestine(1)|lung(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						ACCCCCAAACGAAAATATAGT	0.428000													18	29					0	0	1	0	0
ATM	472	broad.mit.edu	37	11	108202232	108202232	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:108202232G>A	ENST00000278616.4	+	51	7962	c.7577G>A	c.(7576-7578)aGa>aAa	p.R2526K	C11orf65_ENST00000525729.1_Intron|ATM_ENST00000452508.2_Missense_Mutation_p.R2526K	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	2526	FAT.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TTGGCTGCTAGAATGGGGACC	0.328000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			5	14					0	0	1	0	0
PCDH11X	27328	broad.mit.edu	37	X	91133281	91133281	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:91133281C>T	ENST00000373094.1	+	2	2887	c.2042C>T	c.(2041-2043)tCt>tTt	p.S681F	PCDH11X_ENST00000298274.8_Missense_Mutation_p.S681F|PCDH11X_ENST00000373088.1_Missense_Mutation_p.S681F|PCDH11X_ENST00000395337.2_Missense_Mutation_p.S681F|PCDH11X_ENST00000504220.1_Missense_Mutation_p.S681F|PCDH11X_ENST00000406881.1_Missense_Mutation_p.S681F|PCDH11X_ENST00000361724.1_Missense_Mutation_p.S681F|PCDH11X_ENST00000361655.2_Missense_Mutation_p.S681F|PCDH11X_ENST00000373097.1_Missense_Mutation_p.S681F	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	681	Cadherin 7.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						TCCAACTGTTCTTATGAATTG	0.433000													42	59					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34083126	34083126	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:34083126G>A	ENST00000373381.4	-	38	6095	c.5919C>T	c.(5917-5919)ttC>ttT	p.F1973F	CSMD2_ENST00000373388.2_Silent_p.F72F|CSMD2_ENST00000373380.1_Silent_p.F846F|CSMD2_ENST00000373377.1_Silent_p.F72F	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1933	CUB 12.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GCTCACACTGGAAAGACACCA	0.587000													11	18					0	0	1	0	0
OR51A4	401666	broad.mit.edu	37	11	4967770	4967770	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:4967770C>T	ENST00000380373.2	-	1	586	c.561G>A	c.(559-561)atG>atA	p.M187I	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001005329.1	NP_001005329.1	Q8NGJ6	O51A4_HUMAN	olfactory receptor, family 51, subfamily A, member 4	187					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|lung(15)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	29		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.22e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGGCCAACTTCATGACATCCT	0.418000													21	12					0	0	1	0	0
PTPRU	10076	broad.mit.edu	37	1	29642514	29642514	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:29642514G>A	ENST00000373779.3	+	24	3493	c.3363_splice	c.e24-1	p.E1122_splice	PTPRU_ENST00000356870.3_Splice_Site_p.E1128_splice|PTPRU_ENST00000345512.3_Splice_Site_p.E1132_splice|PTPRU_ENST00000323874.8_Splice_Site_p.E1128_splice|PTPRU_ENST00000460170.2_Splice_Site_p.E1128_splice|PTPRU_ENST00000428026.2_Splice_Site_p.E1119_splice	NM_001195001.1|NM_133178.3	NP_001181930.1|NP_573439.2	Q92729	PTPRU_HUMAN	protein tyrosine phosphatase, receptor type, U	1132	Tyrosine-protein phosphatase 1.				canonical Wnt receptor signaling pathway|cell differentiation|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transmembrane receptor protein tyrosine phosphatase signaling pathway	cell-cell junction|integral to plasma membrane	beta-catenin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(26)|ovary(1)|prostate(3)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	79		Colorectal(325;0.000399)|Lung NSC(340;0.00953)|all_lung(284;0.0112)|Breast(348;0.0126)|all_neural(195;0.0199)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;6.99e-07)|COAD - Colon adenocarcinoma(152;3.18e-05)|STAD - Stomach adenocarcinoma(196;0.0234)|READ - Rectum adenocarcinoma(331;0.0686)|BRCA - Breast invasive adenocarcinoma(304;0.0871)		CCTGTTCCAGGAGCAGTACAT	0.542000													8	8					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144865903	144865903	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:144865903C>T	ENST00000369359.4	-	38	6123	c.6085G>A	c.(6085-6087)Ggc>Agc	p.G2029S	PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.G1787S|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.G1893S|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.G1978S|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.G1893S			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	1893					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GACTCCAGGCCCTGACTGTAG	0.453000			T	PDGFRB	MPD								35	175					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10362679	10362679	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:10362679G>A	ENST00000255381.2	-	15	1586	c.1476C>T	c.(1474-1476)ttC>ttT	p.F492F	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	492	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TGTGGTGGTTGAAAAACTGTT	0.473000													31	17					0	0	1	0	0
SASH3	54440	broad.mit.edu	37	X	128922472	128922472	+	Silent	SNP	G	G	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:128922472G>C	ENST00000356892.3	+	3	333	c.219G>C	c.(217-219)ggG>ggC	p.G73G		NM_018990.3	NP_061863.1	O75995	SASH3_HUMAN	SAM and SH3 domain containing 3	73										breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	12						AAAAGCTGGGGAAGAAGTGGA	0.532000													13	23					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1507821	1507821	+	Missense_Mutation	SNP	G	G	A	rs145974595		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:1507821G>A	ENST00000345913.4	+	14	2579	c.2488G>A	c.(2488-2490)Gag>Aag	p.E830K	TPO_ENST00000382198.1_Missense_Mutation_p.E657K|TPO_ENST00000349624.3_Missense_Mutation_p.E657K|TPO_ENST00000346956.3_Intron|TPO_ENST00000337415.3_Missense_Mutation_p.E830K|TPO_ENST00000329066.4_Missense_Mutation_p.E830K|TPO_ENST00000497517.2_3'UTR|TPO_ENST00000382201.3_Missense_Mutation_p.E773K	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	830	EGF-like; calcium-binding (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GGACCCCTACGAGTTAGGAGA	0.562000													20	12					0	0	1	0	0
PRSS1	5644	broad.mit.edu	37	7	142459658	142459658	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:142459658C>T	ENST00000486171.1	+	4	293	c.276C>T	c.(274-276)atC>atT	p.I92I	PRSS1_ENST00000311737.7_Silent_p.I78I			P07477	TRY1_HUMAN	protease, serine, 1 (trypsin 1)	78	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(24)|prostate(2)	38	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			AGCACAACATCGAAGTCCTGG	0.547000													41	106					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3842066	3842066	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:3842066T>C	ENST00000262367.5	-	5	2055	c.1246A>G	c.(1246-1248)Atc>Gtc	p.I416V	CREBBP_ENST00000382070.3_Intron	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	416					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CAATGAGAGATGATTTGTCGT	0.408000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						13	26					0	0	1	0	0
IGHD	3495	broad.mit.edu	37	14	106311849	106311849	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:106311849G>A	ENST00000390556.2	-	0	161																											TGTATCTCAGGGAAGGTTCTC	0.587000													16	34					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152059796	152059796	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:152059796C>T	ENST00000368806.1	-	3	426	c.362G>A	c.(361-363)tGg>tAg	p.W121*		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	121							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TCCCACTGTCCACTGACCATC	0.443000													30	39					0	0	1	0	0
ZNF835	90485	broad.mit.edu	37	19	57176221	57176221	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:57176221C>T	ENST00000537055.2	-	2	577	c.346G>A	c.(346-348)Ggg>Agg	p.G116R		NM_001005850.2	NP_001005850.2			zinc finger protein 835											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(22)|pancreas(3)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	47						AAGGCCTTCCCGCAGTCCCCG	0.637000													21	34					0	0	1	0	0
CADPS	8618	broad.mit.edu	37	3	62543092	62543092	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:62543092C>T	ENST00000383710.4	-	10	2090	c.1741G>A	c.(1741-1743)Gac>Aac	p.D581N	CADPS_ENST00000357948.3_Missense_Mutation_p.D581N|CADPS_ENST00000283269.9_Missense_Mutation_p.D581N	NM_003716.3	NP_003707.2	Q9ULU8	CAPS1_HUMAN	Ca++-dependent secretion activator	581	PH.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			breast(3)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(24)|lung(38)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(2)	92		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		GGCTGGGGGTCGGTGTAATCC	0.522000													19	41					0	0	1	0	0
ZNF362	149076	broad.mit.edu	37	1	33746006	33746006	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:33746006C>T	ENST00000539719.1	+	5	801	c.631C>T	c.(631-633)Ccc>Tcc	p.P211S	ZNF362_ENST00000373428.5_Missense_Mutation_p.P211S	NM_152493.2	NP_689706.2	Q5T0B9	ZN362_HUMAN	zinc finger protein 362	211					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(4)|lung(2)	10		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				CCTTGTAGTCCCCTATCCCAT	0.672000													6	12					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118230538	118230538	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:118230538G>A	ENST00000402510.2	-	8	1184	c.1185C>T	c.(1183-1185)acC>acT	p.T395T		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	395										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						AACAGCCCTGGGTGGTGGCTG	0.498000													12	17					0	0	1	0	0
HEPH	9843	broad.mit.edu	37	X	65392415	65392415	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:65392415G>A	ENST00000519389.1	+	3	727	c.548G>A	c.(547-549)gGt>gAt	p.G183D	HEPH_ENST00000441993.2_Missense_Mutation_p.G132D|HEPH_ENST00000374727.3_Missense_Mutation_p.G132D|HEPH_ENST00000343002.2_Missense_Mutation_p.G129D|HEPH_ENST00000419594.1_Missense_Mutation_p.G132D|HEPH_ENST00000336279.5_5'UTR			Q9BQS7	HEPH_HUMAN	hephaestin	129	Plastocyanin-like 1.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						CACCCTCATGGTGTCTTCTAC	0.483000													27	46					0	0	1	0	0
VPS13C	54832	broad.mit.edu	37	15	62283975	62283975	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:62283975C>T	ENST00000261517.5	-	17	1453	c.1380G>A	c.(1378-1380)agG>agA	p.R460R	VPS13C_ENST00000395898.3_Silent_p.R417R|VPS13C_ENST00000249837.3_Silent_p.R417R|VPS13C_ENST00000395896.4_Silent_p.R460R	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	460					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						CAGACTTTTTCCTTAATTTTT	0.388000													33	48					0	0	1	0	0
PUM1	9698	broad.mit.edu	37	1	31532132	31532132	+	Silent	SNP	C	C	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:31532132C>A	ENST00000373747.3	-	2	381	c.282G>T	c.(280-282)ggG>ggT	p.G94G	PUM1_ENST00000257075.5_Silent_p.G94G|PUM1_ENST00000373741.4_Silent_p.G130G|PUM1_ENST00000424085.2_Silent_p.G94G|PUM1_ENST00000426105.2_Silent_p.G94G|PUM1_ENST00000373742.2_Silent_p.G130G|PUM1_ENST00000423018.2_Silent_p.G94G|PUM1_ENST00000440538.2_Silent_p.G94G	NM_001020658.1	NP_001018494.1	Q14671	PUM1_HUMAN	pumilio RNA-binding family member 1	94					cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(17)|ovary(2)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	48		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		TTCCTCCTCCCCCAAGCTGCT	0.502000													33	36					9.78485e-24	9.9919e-24	1	1	0
BTK	695	broad.mit.edu	37	X	100608963	100608963	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:100608963C>T	ENST00000308731.7	-	17	1808	c.1645G>A	c.(1645-1647)Gat>Aat	p.D549N	BTK_ENST00000372880.1_Missense_Mutation_p.D373N	NM_000061.2	NP_000052.1	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	549	Protein kinase.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			breast(4)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(25)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						GTGTATTCATCATCCAGGACA	0.473000									Agammaglobulinemia, X-linked				27	45					0	0	1	0	0
CST5	1473	broad.mit.edu	37	20	23860231	23860231	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:23860231C>T	ENST00000304710.4	-	1	156	c.83G>A	c.(82-84)aGg>aAg	p.R28K		NM_001900.4	NP_001891.2	P28325	CYTD_HUMAN	cystatin D	28						extracellular region	cysteine-type endopeptidase inhibitor activity|protein binding			breast(1)|kidney(1)|large_intestine(1)|lung(6)|skin(1)|stomach(1)	11						TGCCAAGGTCCTAGATTGGGC	0.562000													42	58					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123556363	123556363	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:123556363G>A	ENST00000422452.2	-	24	4293	c.4230C>T	c.(4228-4230)ccC>ccT	p.P1410P	TENM1_ENST00000371130.3_Silent_p.P1403P|STAG2_ENST00000469481.1_3'UTR	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GGCAGTGAATGGGGCGTCCTG	0.498000													27	42					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84502582	84502582	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:84502582G>A	ENST00000360700.4	+	3	890	c.4G>A	c.(4-6)Gat>Aat	p.D2N	ZNF711_ENST00000276123.3_Missense_Mutation_p.D2N|ZNF711_ENST00000395402.1_5'UTR|ZNF711_ENST00000373165.3_Missense_Mutation_p.D2N			Q9Y462	ZN711_HUMAN	zinc finger protein 711	2					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						GCTAAGTATGGATTCAGGCGG	0.338000													19	45					0	0	1	0	0
ABCC6P1	653190	broad.mit.edu	37	16	18597253	18597253	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:18597253C>T	ENST00000546162.2	+	0	993					NR_003569.1																						CGCAGTGCAGCCCGGGGGTAA	0.552000													30	48					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124392724	124392724	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:124392724G>A	ENST00000368909.3	+	49	6134	c.6028G>A	c.(6028-6030)Ggc>Agc	p.G2010S	DMBT1_ENST00000330163.4_Missense_Mutation_p.G1382S|DMBT1_ENST00000368955.3_Missense_Mutation_p.G2000S|DMBT1_ENST00000344338.3_Missense_Mutation_p.G2000S|DMBT1_ENST00000359586.6_Missense_Mutation_p.G730S|DMBT1_ENST00000338354.3_Missense_Mutation_p.G2010S|DMBT1_ENST00000368956.2_Missense_Mutation_p.G1382S	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2010	CUB 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TTCCTGCGGAGGCTTCCTATC	0.478000													27	14					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57325615	57325615	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:57325615C>T	ENST00000326441.9	-	10	4558	c.4195G>A	c.(4195-4197)Gtg>Atg	p.V1399M	PEG3_ENST00000423103.2_Missense_Mutation_p.V1399M|PEG3_ENST00000598410.1_Missense_Mutation_p.V1275M|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.V1273M|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000391708.3_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1399	3 X 7 AA repeat of P-E-V-E-A-A-E.|Glu-rich.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GCAGCCTCCACTTCTGGCTCA	0.582000													24	39					0	0	1	0	0
TRBV27	28560	broad.mit.edu	37	7	142423623	142423623	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:142423623C>T	ENST00000506718.1	+	0	631				TRBV27_ENST00000390399.3_RNA																							AGAGGAATTTCCCCCTGATCC	0.498000													17	19					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81839417	81839417	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:81839417G>A	ENST00000550584.2	-	5	783	c.488C>T	c.(487-489)tCt>tTt	p.S163F	PPFIA2_ENST00000552948.1_Missense_Mutation_p.S163F|PPFIA2_ENST00000407050.4_Missense_Mutation_p.S89F|PPFIA2_ENST00000550359.2_Missense_Mutation_p.S10F|PPFIA2_ENST00000333447.7_Missense_Mutation_p.S145F|PPFIA2_ENST00000443686.3_Missense_Mutation_p.S89F|PPFIA2_ENST00000548586.1_Missense_Mutation_p.S163F|PPFIA2_ENST00000549396.1_Missense_Mutation_p.S163F|RP11-315E17.1_ENST00000550272.1_RNA|PPFIA2_ENST00000545296.2_5'UTR|PPFIA2_ENST00000549325.1_Missense_Mutation_p.S145F	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	89										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						TCCTGAGGGAGACTGGGCTTG	0.433000													9	13					0	0	1	0	0
STT3A	3703	broad.mit.edu	37	11	125476270	125476270	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:125476270C>T	ENST00000392708.4	+	8	849	c.690C>T	c.(688-690)ggC>ggT	p.G230G	STT3A_ENST00000531491.1_Silent_p.G138G|STT3A_ENST00000529196.1_Silent_p.G230G	NM_001278503.1|NM_001278504.1|NM_152713.3	NP_001265432.1|NP_001265433.1|NP_689926.1	P46977	STT3A_HUMAN	STT3A, subunit of the oligosaccharyltransferase complex (catalytic)	230					post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity			NS(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(15)|skin(1)	33	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)		TGCTCACAGGCCGTTTCTCTC	0.473000													38	46					0	0	1	0	0
AFAP1L2	84632	broad.mit.edu	37	10	116075334	116075334	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:116075334C>T	ENST00000369271.3	-	6	897	c.597G>A	c.(595-597)aaG>aaA	p.K199K	AFAP1L2_ENST00000304129.4_Silent_p.K199K|AFAP1L2_ENST00000545353.1_Silent_p.K252K	NM_001001936.1|NM_032550.2	NP_001001936.1|NP_115939.1	Q8N4X5	AF1L2_HUMAN	actin filament associated protein 1-like 2	199	PH 1.				inflammatory response|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of transcription, DNA-dependent|regulation of interleukin-6 production|regulation of mitotic cell cycle	cytoplasm	protein tyrosine kinase activator activity|SH2 domain binding|SH3 domain binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|prostate(2)	21		Colorectal(252;0.175)|Breast(234;0.231)		Epithelial(162;0.0219)|all cancers(201;0.0561)		GCCTGTTGTCCTTGATGACAC	0.632000													9	7					0	0	1	0	0
LUM	4060	broad.mit.edu	37	12	91502535	91502535	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:91502535C>T	ENST00000266718.4	-	2	676	c.222G>A	c.(220-222)agG>agA	p.R74R	LUM_ENST00000548071.1_Intron	NM_002345.3	NP_002336.1	P51884	LUM_HUMAN	lumican	74					collagen fibril organization|visual perception	extracellular space|fibrillar collagen	collagen binding|extracellular matrix structural constituent			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	24						TCTGGTTATTCCTAAGGTAAA	0.408000													21	32					0	0	1	0	0
ARHGEF5	7984	broad.mit.edu	37	7	144077024	144077024	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:144077024G>A	ENST00000056217.5	+	15	4843	c.4669G>A	c.(4669-4671)Gag>Aag	p.E1557K	ARHGEF5_ENST00000471847.2_Missense_Mutation_p.E479K	NM_005435.3	NP_005426.2	Q12774	ARHG5_HUMAN	Rho guanine nucleotide exchange factor (GEF) 5	1557	SH3.				intracellular signal transduction|regulation of Rho protein signal transduction	intracellular	GTP binding|protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(6)|kidney(8)|large_intestine(9)|liver(1)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Melanoma(164;0.14)					CTCAGACGGGGAGCGAGGCTG	0.567000													51	70					0	0	1	0	0
TCF12	6938	broad.mit.edu	37	15	57484473	57484473	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:57484473C>T	ENST00000267811.5	+	7	812	c.508C>T	c.(508-510)Cat>Tat	p.H170Y	TCF12_ENST00000333725.5_Missense_Mutation_p.H170Y|TCF12_ENST00000452095.2_Missense_Mutation_p.H166Y|TCF12_ENST00000438423.2_Missense_Mutation_p.H170Y|TCF12_ENST00000557843.1_Missense_Mutation_p.H170Y	NM_003205.3|NM_207038.1	NP_003196.1|NP_996921.1	Q99081	HTF4_HUMAN	transcription factor 12	170					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity		TCF12/NR4A3(2)	breast(2)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(1)|lung(13)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	36		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		GAGACCACTCCATGACTCTGC	0.473000			T	TEC	extraskeletal myxoid chondrosarcoma								17	33					0	0	1	0	0
PPP3CA	5530	broad.mit.edu	37	4	101947217	101947217	+	Splice_Site	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:101947217A>T	ENST00000394854.3	-	14	2054	c.1369_splice	c.e14-1	p.A457_splice	PPP3CA_ENST00000523694.2_Splice_Site_p.A390_splice|PPP3CA_ENST00000394853.4_Splice_Site_p.A447_splice|PPP3CA_ENST00000507176.1_Splice_Site_p.A359_splice|PPP3CA_ENST00000512215.1_Splice_Site_p.A225_splice|PPP3CA_ENST00000323055.6_Splice_Site_p.A405_splice	NM_000944.4	NP_000935.1	Q08209	PP2BA_HUMAN	protein phosphatase 3, catalytic subunit, alpha isozyme	457					protein dephosphorylation	calcineurin complex|cytosol|nucleus	calcium ion binding|calmodulin binding			breast(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|urinary_tract(1)	20				OV - Ovarian serous cystadenocarcinoma(123;6.79e-08)		ATCCTTTGATAGCTAAACAGA	0.428000													8	23					0	0	1	0	0
UPF2	26019	broad.mit.edu	37	10	11997355	11997355	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:11997355G>A	ENST00000356352.2	-	13	3199	c.2726C>T	c.(2725-2727)tCc>tTc	p.S909F	UPF2_ENST00000357604.5_Missense_Mutation_p.S909F|UPF2_ENST00000397053.2_Missense_Mutation_p.S909F			Q9HAU5	RENT2_HUMAN	UPF2 regulator of nonsense transcripts homolog (yeast)	909	MIF4G 3.|Sufficient for interaction with EIF4A1 and EIF1.|Sufficient for interaction with UPF3A and UPF3B.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	exon-exon junction complex|perinuclear region of cytoplasm	identical protein binding|RNA binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(14)|lung(17)|ovary(2)|skin(3)|urinary_tract(2)	56		Renal(717;0.228)				TGGGTCCAGGGAACTTGGAGA	0.418000													15	7					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130417024	130417024	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:130417024G>A	ENST00000370904.1	-	12	1765	c.855C>T	c.(853-855)taC>taT	p.Y285Y	IGSF1_ENST00000361420.3_Silent_p.Y294Y|IGSF1_ENST00000370903.3_Silent_p.Y294Y|IGSF1_ENST00000370910.1_Silent_p.Y285Y			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	294	Ig-like C2-type 3.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						AAAAACAGAGGTAATGTCCAG	0.403000													16	31					0	0	1	0	0
CNGB1	1258	broad.mit.edu	37	16	57931788	57931788	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:57931788G>A	ENST00000564448.1	-	30	3049	c.2989C>T	c.(2989-2991)Cag>Tag	p.Q997*	CNGB1_ENST00000251102.8_Nonsense_Mutation_p.Q1003*			Q14028	CNGB1_HUMAN	cyclic nucleotide gated channel beta 1	1003					sensory perception of smell	intracellular cyclic nucleotide activated cation channel complex	cAMP binding|intracellular cAMP activated cation channel activity			breast(7)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(11)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	54						TGCCCTGCCTGGATGATGTAC	0.547000													50	80					0	0	1	0	0
NLRP13	126204	broad.mit.edu	37	19	56424312	56424312	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:56424312C>T	ENST00000588751.1	-	5	895	c.871G>A	c.(871-873)Gat>Aat	p.D291N	NLRP13_ENST00000342929.3_Missense_Mutation_p.D291N			Q86W25	NAL13_HUMAN	NLR family, pyrin domain containing 13	291	NACHT.						ATP binding	p.D291N(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(58)|ovary(4)|pancreas(2)|prostate(2)|skin(13)|stomach(2)|urinary_tract(1)	109		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GCATCAAAATCGGGCCAATCC	0.398000													25	23					0	0	1	0	0
VPS33A	65082	broad.mit.edu	37	12	122729243	122729243	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:122729243G>A	ENST00000267199.4	-	7	954	c.842C>T	c.(841-843)cCc>cTc	p.P281L	RP11-512M8.5_ENST00000535844.1_Missense_Mutation_p.P242L	NM_022916.4	NP_075067.2	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33 homolog A (S. cerevisiae)	281					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	28	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		TGCTTCCGTGGGGAGGTCCTT	0.488000													23	23					0	0	1	0	0
PRKCQ	5588	broad.mit.edu	37	10	6527123	6527123	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:6527123C>T	ENST00000263125.5	-	10	1108	c.1009G>A	c.(1009-1011)Gga>Aga	p.G337R	PRKCQ_ENST00000397176.2_Missense_Mutation_p.G337R|PRKCQ_ENST00000539722.1_Missense_Mutation_p.G212R	NM_006257.3	NP_006248.1	Q04759	KPCT_HUMAN	protein kinase C, theta	337					axon guidance|cellular component disassembly involved in apoptosis|intracellular signal transduction|membrane protein ectodomain proteolysis|platelet activation|regulation of cell growth|T cell receptor signaling pathway	cytosol	ATP binding|metal ion binding|protein binding|protein kinase C activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|liver(1)|lung(13)|ovary(4)|prostate(1)|skin(4)|stomach(2)	45						CCTCTTTTTCCCGGTGTCGGT	0.433000													37	21					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12655875	12655875	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:12655875C>T	ENST00000425538.1	+	10	1470	c.1270C>T	c.(1270-1272)Cct>Tct	p.P424S	MYOCD_ENST00000343344.4_Missense_Mutation_p.P424S|MYOCD_ENST00000395988.1_Missense_Mutation_p.P328S	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	424					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TGTCACTTTTCCTGTCACACC	0.572000													26	7					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124345875	124345875	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:124345875G>A	ENST00000368909.3	+	16	1865	c.1759G>A	c.(1759-1761)Gaa>Aaa	p.E587K	DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000368955.3_Missense_Mutation_p.E577K|DMBT1_ENST00000344338.3_Missense_Mutation_p.E577K|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000338354.3_Missense_Mutation_p.E587K|DMBT1_ENST00000368956.2_Intron	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	587	SRCR 4.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGGCCATAGTGAAGACGCTGG	0.517000													38	63					0	0	1	0	0
ABCA6	23460	broad.mit.edu	37	17	67084326	67084326	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:67084326C>T	ENST00000284425.2	-	28	3854	c.3680G>A	c.(3679-3681)cGa>cAa	p.R1227Q	ABCA6_ENST00000446604.2_5'UTR	NM_080284.2	NP_525023.2	Q8N139	ABCA6_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 6	1227					transport	integral to membrane	ATP binding|ATPase activity			breast(6)|endometrium(5)|kidney(17)|large_intestine(18)|lung(20)|ovary(3)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	82	Breast(10;5.65e-12)					AGGATCTTTTCGCATTCTTTT	0.318000													3	7					0	0	1	0	0
CFHR4	10877	broad.mit.edu	37	1	196879546	196879546	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:196879546G>A	ENST00000367416.2	+	6	1069	c.932G>A	c.(931-933)gGa>gAa	p.G311E	CFHR2_ENST00000367421.3_Intron|CFHR4_ENST00000367418.1_Missense_Mutation_p.G65E|CFHR4_ENST00000251424.4_Intron	NM_001201550.2|NM_001201551.1	NP_001188479.1|NP_001188480.1			complement factor H-related 4											NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	36						ACTCCTTCAGGAAGTTACTGG	0.408000													22	25					0	0	1	0	0
TUBA3D	113457	broad.mit.edu	37	2	132236896	132236896	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:132236896G>A	ENST00000321253.6	+	3	349	c.242G>A	c.(241-243)gGg>gAg	p.G81E	TUBA3D_ENST00000409047.2_3'UTR	NM_080386.3	NP_525125.2	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	81					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(18)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32				BRCA - Breast invasive adenocarcinoma(221;0.13)		GTGCGCACAGGGACCTACAGG	0.512000													37	20					0	0	1	0	0
SPATA5L1	79029	broad.mit.edu	37	15	45710813	45710813	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:45710813C>T	ENST00000305560.6	+	7	2126	c.2027C>T	c.(2026-2028)tCc>tTc	p.S676F	SPATA5L1_ENST00000533841.1_3'UTR	NM_024063.2	NP_076968.2	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	676						cytoplasm	ATP binding|nucleoside-triphosphatase activity			kidney(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	14		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		CCTGATGTCTCCTTAGAAAAC	0.343000													18	24					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61537180	61537180	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:61537180G>A	ENST00000370371.4	-	6	2002	c.1647C>T	c.(1645-1647)atC>atT	p.I549I	DIDO1_ENST00000395340.1_Intron|DIDO1_ENST00000370366.1_Intron|DIDO1_ENST00000395335.2_Intron|DIDO1_ENST00000266071.5_Intron|DIDO1_ENST00000354665.4_Silent_p.I549I|DIDO1_ENST00000370368.1_Silent_p.I549I|DIDO1_ENST00000266070.4_Intron|DIDO1_ENST00000395343.1_Intron	NM_022105.4	NP_071388.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	0					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					AGGCCCAGGGGATGGCTATCC	0.562000													20	31					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25479234	25479234	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:25479234G>A	ENST00000453082.2	+	0	1775					NR_003343.1																						ACTCGTGTTGGGCCCACAGGC	0.592000													10	10					0	0	1	0	0
DLGAP3	58512	broad.mit.edu	37	1	35334369	35334369	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:35334369C>T	ENST00000373347.1	-	9	2590	c.2322G>A	c.(2320-2322)tgG>tgA	p.W774*	DLGAP3_ENST00000235180.4_Nonsense_Mutation_p.W774*			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	774					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				CGCGCTCTATCCAGGAGTCAC	0.736000													7	11					0	0	1	0	0
TMEM39A	55254	broad.mit.edu	37	3	119177008	119177008	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:119177008G>A	ENST00000319172.5	-	3	613	c.193C>T	c.(193-195)Cct>Tct	p.P65S	TMEM39A_ENST00000486159.1_5'UTR	NM_018266.1	NP_060736.1	Q9NV64	TM39A_HUMAN	transmembrane protein 39A	65						integral to membrane				NS(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)	13				GBM - Glioblastoma multiforme(114;0.244)		GGCAAGTCAGGAATTTGGCAA	0.423000													14	16					0	0	1	0	0
COL5A1	1289	broad.mit.edu	37	9	137623950	137623950	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:137623950G>A	ENST00000371817.3	+	9	1780	c.1366G>A	c.(1366-1368)Gga>Aga	p.G456R		NM_000093.3|NM_001278074.1	NP_000084.3|NP_001265003.1	P20908	CO5A1_HUMAN	collagen, type V, alpha 1	456	Interrupted collagenous region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(26)|liver(2)|lung(36)|ovary(4)|pancreas(4)|prostate(5)|skin(10)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	115		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		AGGCCAAAAGGGAGAACCAGC	0.547000													16	14					0	0	1	0	0
DHX34	9704	broad.mit.edu	37	19	47880400	47880400	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:47880400C>T	ENST00000328771.4	+	13	2992	c.2643C>T	c.(2641-2643)ttC>ttT	p.F881F		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	881						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		TCCTCAGCTTCGTGTCCCTGC	0.632000													12	18					0	0	1	0	0
CHRM4	1132	broad.mit.edu	37	11	46408063	46408063	+	Silent	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:46408063G>T	ENST00000433765.2	-	1	44	c.45C>A	c.(43-45)tcC>tcA	p.S15S		NM_000741.2	NP_000732.2	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	15					cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	20				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	CCAGGCGCACGGACTGATTGC	0.577000													26	47					8.24728e-16	8.39136e-16	1	1	0
OGFOD2	79676	broad.mit.edu	37	12	123463464	123463464	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:123463464G>A	ENST00000397389.2	+	7	1255	c.516G>A	c.(514-516)ctG>ctA	p.L172L	OGFOD2_ENST00000545612.1_Silent_p.L68L|RP11-197N18.2_ENST00000540866.2_RNA|OGFOD2_ENST00000538628.1_Silent_p.L68L|OGFOD2_ENST00000545317.1_Silent_p.L68L|ABCB9_ENST00000542678.1_5'UTR|OGFOD2_ENST00000538755.1_Silent_p.L68L|OGFOD2_ENST00000536150.1_Silent_p.L68L|OGFOD2_ENST00000542117.1_3'UTR|OGFOD2_ENST00000228922.7_Silent_p.L232L|OGFOD2_ENST00000454694.2_Silent_p.L68L	NM_024623.1	NP_078899.1	Q6N063	OGFD2_HUMAN	2-oxoglutarate and iron-dependent oxygenase domain containing 2	232							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(1)|endometrium(2)|lung(4)|pancreas(1)	8	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.11e-05)|Epithelial(86;0.000127)|BRCA - Breast invasive adenocarcinoma(302;0.107)	Vitamin C(DB00126)	ACCTGGAGCTGGGCTGCCACT	0.637000													22	25					0	0	1	0	0
RGS7BP	401190	broad.mit.edu	37	5	63890536	63890536	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:63890536G>A	ENST00000334025.2	+	4	789		c.e4-1			NM_001029875.1|NM_001271890.1|NM_001271891.1	NP_001025046.1|NP_001258819.1|NP_001258820.1	Q6MZT1	R7BP_HUMAN	regulator of G-protein signaling 7 binding protein						negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane				breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|stomach(1)	11		Lung NSC(810;0.000518)|Prostate(74;0.0435)|Ovarian(174;0.186)		Lung(70;0.147)		CCCTCCCTTAGGAAAGGAACC	0.473000													24	30					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66945813	66945813	+	Silent	SNP	G	G	A	rs145107014		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:66945813G>A	ENST00000299752.4	-	13	1972	c.1779C>T	c.(1777-1779)agC>agT	p.S593S	CDH16_ENST00000570262.1_Silent_p.S513S|CDH16_ENST00000568632.1_Silent_p.S496S|CDH16_ENST00000394055.3_Silent_p.S593S|CDH16_ENST00000565796.1_Silent_p.S593S	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	593	Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		TGAGGGTTCGGCTGATGGGGT	0.627000													28	30					0	0	1	0	0
SF3B2	10992	broad.mit.edu	37	11	65835464	65835464	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:65835464C>T	ENST00000528302.1	+	19	2381	c.2327C>T	c.(2326-2328)gCc>gTc	p.A776V	SF3B2_ENST00000322535.6_Missense_Mutation_p.A793V|RP11-1167A19.2_ENST00000529036.1_Intron			Q13435	SF3B2_HUMAN	splicing factor 3b, subunit 2, 145kDa	793					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			breast(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(2)|lung(14)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	41						AAGAGAACAGCCACTGTTGGA	0.512000											OREG0021094	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	32	52					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140734830	140734830	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140734830G>A	ENST00000571252.1	+	1	63	c.63G>A	c.(61-63)ggG>ggA	p.G21G	PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCTCCTGGGGGTTCTGGTGG	0.617000													27	41					0	0	1	0	0
PIWIL2	55124	broad.mit.edu	37	8	22161612	22161612	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:22161612C>T	ENST00000356766.6	+	11	1408	c.1260C>T	c.(1258-1260)acC>acT	p.T420T	PIWIL2_ENST00000454009.2_Silent_p.T420T|PIWIL2_ENST00000521356.1_Silent_p.T420T	NM_018068.3	NP_060538.2	Q8TC59	PIWL2_HUMAN	piwi-like RNA-mediated gene silencing 2	420	PAZ.				DNA methylation involved in gamete generation|gene silencing by RNA|germ-line stem cell maintenance|multicellular organismal development|oogenesis|piRNA metabolic process|positive regulation of translation|RNA 5'-end processing|spermatogenesis	chromatoid body|pi-body	piRNA binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(14)|lung(14)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	46				Colorectal(74;0.018)|COAD - Colon adenocarcinoma(73;0.0707)		TTGTTATCACCCGATATAACA	0.393000													12	39					0	0	1	0	0
FAM154A	158297	broad.mit.edu	37	9	18941723	18941723	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:18941723G>A	ENST00000380534.4	-	3	612	c.333C>T	c.(331-333)ccC>ccT	p.P111P	FAM154A_ENST00000542071.1_Intron|FAM154A_ENST00000380530.1_Intron	NM_153707.2	NP_714918.2	Q8IYX7	F154A_HUMAN	family with sequence similarity 154, member A	111										breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(13)|pancreas(1)|prostate(1)|skin(1)	26				GBM - Glioblastoma multiforme(50;6.53e-16)		AGACAGGGTAGGGATTGTAAT	0.478000													28	41					0	0	1	0	0
ANPEP	290	broad.mit.edu	37	15	90347724	90347724	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:90347724G>A	ENST00000300060.6	-	5	1335	c.1022C>T	c.(1021-1023)tCa>tTa	p.S341L		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	341	Interaction with HCoV-229E.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	CCACTCACCTGATTTTGGGAG	0.597000													28	56					0	0	1	0	0
NELL2	4753	broad.mit.edu	37	12	45059275	45059275	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:45059275G>A	ENST00000429094.2	-	13	1940	c.1436C>T	c.(1435-1437)tCa>tTa	p.S479L	NELL2_ENST00000549027.1_Missense_Mutation_p.S478L|NELL2_ENST00000395487.2_Missense_Mutation_p.S478L|NELL2_ENST00000452445.2_Missense_Mutation_p.S479L|NELL2_ENST00000437801.2_Missense_Mutation_p.S529L|NELL2_ENST00000333837.4_Missense_Mutation_p.S502L|NELL2_ENST00000551601.1_Missense_Mutation_p.S478L	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	479	EGF-like 2; calcium-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		ACCTGTACATGAATAATCATC	0.328000													10	11					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2705049	2705049	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:2705049C>T	ENST00000399655.1	+	20	2938	c.2673C>T	c.(2671-2673)ctC>ctT	p.L891L	CACNA1C_ENST00000402845.3_Silent_p.L891L|CACNA1C_ENST00000399634.1_Silent_p.L891L|CACNA1C_ENST00000347598.4_Silent_p.L891L|CACNA1C_ENST00000399591.1_Silent_p.L891L|CACNA1C_ENST00000399629.1_Silent_p.L891L|CACNA1C_ENST00000399601.1_Silent_p.L891L|CACNA1C_ENST00000399638.1_Silent_p.L891L|CACNA1C_ENST00000327702.7_Silent_p.L891L|CACNA1C_ENST00000399637.1_Silent_p.L891L|CACNA1C_ENST00000399649.1_Silent_p.L891L|CACNA1C_ENST00000344100.3_Silent_p.L891L|CACNA1C_ENST00000406454.3_Silent_p.L891L|CACNA1C_ENST00000399597.1_Silent_p.L891L|CACNA1C_ENST00000480911.1_Silent_p.L891L|CACNA1C_ENST00000399644.1_Silent_p.L891L|CACNA1C_ENST00000399641.1_Silent_p.L891L|CACNA1C_ENST00000399595.1_Silent_p.L891L|CACNA1C_ENST00000399603.1_Silent_p.L891L|CACNA1C_ENST00000399617.1_Silent_p.L891L|CACNA1C_ENST00000335762.5_Silent_p.L916L|CACNA1C_ENST00000399621.1_Silent_p.L891L|CACNA1C_ENST00000399606.1_Silent_p.L891L	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	891					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGTTTCGCCTCCAGTGCCACC	0.582000													12	33					0	0	1	0	0
IGHV5-51	28388	broad.mit.edu	37	14	107034839	107034839	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:107034839G>A	ENST00000390626.2	-	0	299																											TGGAAGGACGGGCTGTATCTG	0.587000													21	48					0	0	1	0	0
TC2N	123036	broad.mit.edu	37	14	92258807	92258807	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:92258807C>T	ENST00000435962.2	-	9	1274	c.951G>A	c.(949-951)agG>agA	p.R317R	TC2N_ENST00000340892.5_Silent_p.R317R|TC2N_ENST00000556018.1_Intron|TC2N_ENST00000360594.5_Silent_p.R317R	NM_001128596.1	NP_001122068.1	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	317						nucleus				breast(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(5)|skin(1)|upper_aerodigestive_tract(2)	18				COAD - Colon adenocarcinoma(157;0.218)		TGGTTTTCTTCCTGGGAGTCT	0.343000													25	36					0	0	1	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83352835	83352835	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:83352835C>T	ENST00000262752.2	-	19	1805	c.1798G>A	c.(1798-1800)Gat>Aat	p.D600N	RPS6KA6_ENST00000543399.1_Missense_Mutation_p.D600N|RPS6KA6_ENST00000495332.1_5'UTR	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	600	Protein kinase 2.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						CAAGCAGCATCATATCCCTGT	0.308000													44	56					0	0	1	0	0
CACNA1G	8913	broad.mit.edu	37	17	48696338	48696338	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:48696338C>T	ENST00000352832.5	+	31	6020	c.5648C>T	c.(5647-5649)tCa>tTa	p.S1883L	CACNA1G_ENST00000512389.1_Missense_Mutation_p.S1906L|CACNA1G_ENST00000513964.1_Missense_Mutation_p.S1872L|CACNA1G_ENST00000502264.1_Missense_Mutation_p.S1894L|CACNA1G_ENST00000442258.2_Missense_Mutation_p.S1876L|CACNA1G_ENST00000507609.1_Missense_Mutation_p.S1910L|CACNA1G_ENST00000358244.5_Missense_Mutation_p.S1883L|CACNA1G_ENST00000360761.4_Missense_Mutation_p.S1894L|CACNA1G_ENST00000510115.1_Missense_Mutation_p.S1883L|CACNA1G_ENST00000507510.2_Missense_Mutation_p.S1917L|CACNA1G_ENST00000515411.1_Missense_Mutation_p.S1899L|CACNA1G_ENST00000354983.4_Missense_Mutation_p.S1883L|CACNA1G_ENST00000514181.1_Missense_Mutation_p.S1892L|CACNA1G_ENST00000510366.1_Missense_Mutation_p.S1865L|CACNA1G_ENST00000513689.2_Missense_Mutation_p.S1872L|CACNA1G_ENST00000515765.1_Missense_Mutation_p.S1906L|CACNA1G_ENST00000515165.1_Missense_Mutation_p.S1917L|CACNA1G_ENST00000359106.5_Missense_Mutation_p.S1917L|CACNA1G_ENST00000514717.1_Missense_Mutation_p.S1860L|CACNA1G_ENST00000429973.2_Missense_Mutation_p.S1899L|CACNA1G_ENST00000503485.1_Missense_Mutation_p.S1883L|CACNA1G_ENST00000505165.1_Missense_Mutation_p.S1917L|CACNA1G_ENST00000514079.1_Missense_Mutation_p.S1924L|CACNA1G_ENST00000507336.1_Missense_Mutation_p.S1906L|CACNA1G_ENST00000507896.1_Missense_Mutation_p.S1906L	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1917					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CACGCGAGATCAGCCTCCCAC	0.711000													9	16					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155215137	155215137	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:155215137G>A	ENST00000460012.1	-	15	2133	c.1776C>T	c.(1774-1776)tcC>tcT	p.S592S	PLCH1_ENST00000447496.2_Silent_p.S610S|PLCH1_ENST00000340059.7_Silent_p.S610S|PLCH1_ENST00000334686.6_Silent_p.S592S|PLCH1_ENST00000414191.1_Silent_p.S592S|PLCH1_ENST00000494598.1_Silent_p.S610S			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	610					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			GAGCGGCCACGGAGTTTGTGT	0.443000													13	42					0	0	1	0	0
DCBLD2	131566	broad.mit.edu	37	3	98600485	98600485	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:98600485A>G	ENST00000326840.6	-	2	694	c.332T>C	c.(331-333)gTt>gCt	p.V111A	DCBLD2_ENST00000469648.1_Intron|DCBLD2_ENST00000326857.9_Missense_Mutation_p.V111A	NM_080927.3	NP_563615.3	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	111	CUB.				cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				breast(1)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|prostate(1)|stomach(2)	25						TTTGATGCGAACTCTCTCTCC	0.408000													36	61					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34174862	34174862	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:34174862G>A	ENST00000373380.1	-	1	242	c.22C>T	c.(22-24)Cca>Tca	p.P8S	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373381.4_Intron			Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	749						integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CACTCAGCTGGAAAGAGAATC	0.448000													7	7					0	0	1	0	0
AVIL	10677	broad.mit.edu	37	12	58197442	58197442	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:58197442C>T	ENST00000537081.1	-	14	1660	c.1661G>A	c.(1660-1662)gGg>gAg	p.G554E	TSFM_ENST00000548851.1_Intron|AVIL_ENST00000550083.1_Intron|AVIL_ENST00000257861.3_Missense_Mutation_p.G561E			O75366	AVIL_HUMAN	advillin	561	Core (By similarity).				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(6)	32	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					CCGCTCATCCCCACTAGACCC	0.567000											OREG0021955	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	12					0	0	1	0	0
FNBP1L	54874	broad.mit.edu	37	1	94014865	94014865	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:94014865C>T	ENST00000260506.8	+	13	1510	c.1359C>T	c.(1357-1359)aaC>aaT	p.N453N	FNBP1L_ENST00000370256.4_Silent_p.N506N|FNBP1L_ENST00000370253.2_Silent_p.N453N|FNBP1L_ENST00000271234.7_Silent_p.N511N|FNBP1L_ENST00000604705.1_Silent_p.N511N	NM_001024948.2|NM_017737.4	NP_001020119.1|NP_060207.2	Q5T0N5	FBP1L_HUMAN	formin binding protein 1-like	511	Interaction with CDC42.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	lipid binding			breast(2)|kidney(2)|large_intestine(4)|lung(2)|urinary_tract(1)	11		all_lung(203;0.00206)|Lung NSC(277;0.00902)|Melanoma(281;0.155)		all cancers(265;0.00666)|GBM - Glioblastoma multiforme(16;0.0378)|Epithelial(280;0.111)		ATGATGCAAACCAGGAAGTCC	0.388000													6	23					0	0	1	0	0
PDILT	204474	broad.mit.edu	37	16	20384133	20384133	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:20384133G>A	ENST00000302451.4	-	7	1157	c.909C>T	c.(907-909)ttC>ttT	p.F303F		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	303					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						CCTTGTTTTGGAATTCCTTTG	0.468000													14	28					0	0	1	0	0
P2RY8	286530	broad.mit.edu	37	X	1584687	1584687	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:1584687G>A	ENST00000381297.4	-	2	975	c.765C>T	c.(763-765)ttC>ttT	p.F255F		NM_178129.4	NP_835230.1	Q86VZ1	P2RY8_HUMAN	purinergic receptor P2Y, G-protein coupled, 8	255						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)	23		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CCAGGAGCACGAAGTTGTTGG	0.652000			T	CRLF2	"""B-ALL, Downs associated ALL"""								11	25					0	0	1	0	0
TH	7054	broad.mit.edu	37	11	2186472	2186472	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:2186472C>T	ENST00000381178.1	-	13	1435	c.1417G>A	c.(1417-1419)Gac>Aac	p.D473N	TH_ENST00000381175.1_Missense_Mutation_p.D469N|TH_ENST00000333684.5_Missense_Mutation_p.D352N|TH_ENST00000352909.3_Missense_Mutation_p.D442N	NM_199292.2	NP_954986.2	P07101	TY3H_HUMAN	tyrosine hydroxylase	473					dopamine biosynthetic process from tyrosine|embryonic camera-type eye morphogenesis|epinephrine biosynthetic process|eye photoreceptor cell development|heart morphogenesis|hormone biosynthetic process|learning|locomotory behavior|memory|neurotransmitter biosynthetic process|neurotransmitter secretion|norepinephrine biosynthetic process|pigmentation|regulation of heart contraction|response to ethanol|response to hypoxia|synaptic transmission, dopaminergic|visual perception	cytosol|internal side of plasma membrane|melanosome membrane|nucleus|perikaryon|smooth endoplasmic reticulum	protein binding|tyrosine 3-monooxygenase activity			NS(1)|endometrium(1)|large_intestine(1)|lung(7)|skin(1)	11		all_epithelial(84;1.46e-23)|Lung NSC(207;4.44e-11)|all_lung(207;1.11e-09)|Ovarian(85;1.78e-06)|Breast(177;1.78e-05)|Medulloblastoma(188;0.0208)|all_neural(188;0.0416)	Colorectal(5;0.00245)|COAD - Colon adenocarcinoma(6;0.0239)	BRCA - Breast invasive adenocarcinoma(625;8.45e-09)|Lung(200;0.000152)|LUSC - Lung squamous cell carcinoma(625;0.00154)	L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Metyrosine(DB00765)|Tetrahydrobiopterin(DB00360)	CTGAGCTTGTCCTTGGCGTCA	0.632000													27	43					0	0	1	0	0
KRT32	3882	broad.mit.edu	37	17	39620353	39620353	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:39620353C>T	ENST00000225899.3	-	5	1076	c.973G>A	c.(973-975)Gag>Aag	p.E325K		NM_002278.3	NP_002269.3	Q14532	K1H2_HUMAN	keratin 32	325	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(137;0.000812)				GCCTGCAGCTCGATCTCCAGC	0.592000													12	27					0	0	1	0	0
FRMPD4	9758	broad.mit.edu	37	X	12516831	12516831	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:12516831C>A	ENST00000380682.1	+	2	580	c.74C>A	c.(73-75)cCc>cAc	p.P25H		NM_014728.3	NP_055543.2	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	25					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			breast(1)|central_nervous_system(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)	22						TGGCCGCCTCCCTCGGGAACC	0.512000													10	30					3.07112e-06	3.08757e-06	1	1	0
PVRL2	5819	broad.mit.edu	37	19	45368641	45368641	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:45368641G>C	ENST00000252483.5	+	2	202	c.202G>C	c.(202-204)Gtg>Ctg	p.V68L	PVRL2_ENST00000252485.4_Missense_Mutation_p.V68L	NM_001042724.1	NP_001036189.1	Q92692	PVRL2_HUMAN	poliovirus receptor-related 2 (herpesvirus entry mediator B)	68	Ig-like V-type.				adherens junction organization|adhesion to symbiont|cell junction assembly|homophilic cell adhesion|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity|viral envelope fusion with host membrane|virion attachment, binding of host cell surface coreceptor	cell surface|integral to membrane|zonula adherens	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(6)|lung(5)	13	Lung NSC(12;0.00195)|all_lung(12;0.00522)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0143)		CATCTCCCTGGTGACCTGGCA	0.657000													15	28					0	0	1	0	0
BMP1	649	broad.mit.edu	37	8	22069155	22069155	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:22069155C>T	ENST00000306385.5	+	20	3545	c.2875C>T	c.(2875-2877)Cac>Tac	p.H959Y	BMP1_ENST00000354870.5_3'UTR	NM_006129.4	NP_006120.1	P13497	BMP1_HUMAN	bone morphogenetic protein 1	959	CUB 5.				cartilage condensation|cell differentiation|lipid metabolic process|lipoprotein metabolic process|ossification|positive regulation of cartilage development|proteolysis	extracellular space	calcium ion binding|cytokine activity|growth factor activity|metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(3)	30				Colorectal(74;0.00229)|COAD - Colon adenocarcinoma(73;0.0661)|READ - Rectum adenocarcinoma(644;0.11)		GGTGAAGTTCCACTCGGATGA	0.562000													35	38					0	0	1	0	0
PSG9	5678	broad.mit.edu	37	19	43772148	43772148	+	Missense_Mutation	SNP	G	G	A	rs139507205	by1000genomes	TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:43772148G>A	ENST00000244293.7	-	2	284	c.218C>T	c.(217-219)aCg>aTg	p.T73M	PSG9_ENST00000418820.2_Missense_Mutation_p.T73M|PSG9_ENST00000270077.3_Missense_Mutation_p.T73M|PSG9_ENST00000291752.5_Missense_Mutation_p.T73M|PSG9_ENST00000596730.1_Missense_Mutation_p.T73M|PSG9_ENST00000443718.3_Missense_Mutation_p.T73M|PSG9_ENST00000593948.1_Missense_Mutation_p.T73M			Q00887	PSG9_HUMAN	pregnancy specific beta-1-glycoprotein 9	73	Ig-like V-type.				female pregnancy	extracellular region				central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	41		Prostate(69;0.00682)				GTAGAGGTCCGTCATTTCCCC	0.428000													4	140					0	0	1	0	0
WDR17	116966	broad.mit.edu	37	4	177041199	177041199	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:177041199G>A	ENST00000393643.2	+	4	741	c.489G>A	c.(487-489)ggG>ggA	p.G163G	WDR17_ENST00000508596.1_Silent_p.G163G|WDR17_ENST00000280190.4_Silent_p.G187G|WDR17_ENST00000507824.2_Silent_p.G187G	NM_170710.4	NP_733828.2	Q8IZU2	WDR17_HUMAN	WD repeat domain 17	187										breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(18)|lung(46)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	92		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		ACCAAAAGGGGAAAGTTGTGT	0.348000													23	38					0	0	1	0	0
RABAC1	10567	broad.mit.edu	37	19	42462917	42462917	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:42462917G>A	ENST00000222008.6	-	2	337	c.240C>T	c.(238-240)ttC>ttT	p.F80F	RABAC1_ENST00000601078.1_5'UTR|RABAC1_ENST00000601891.1_Silent_p.F80F	NM_006423.2	NP_006414.2	Q9UI14	PRAF1_HUMAN	Rab acceptor 1 (prenylated)	80						cell junction|Golgi apparatus|integral to membrane|synaptic vesicle	identical protein binding			central_nervous_system(1)|kidney(1)|prostate(1)	3						CCAGGAACACGAACACATAGT	0.662000													8	16					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76910700	76910700	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:76910700G>A	ENST00000409709.3	+	35	4961	c.4689G>A	c.(4687-4689)gcG>gcA	p.A1563A	MYO7A_ENST00000458637.2_Silent_p.A1525A|MYO7A_ENST00000409619.2_Silent_p.A1514A	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1563	FERM 1.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GCAGGGGAGCGAAAACGACGG	0.632000													6	14					0	0	1	0	0
MLXIPL	51085	broad.mit.edu	37	7	73010776	73010776	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:73010776G>A	ENST00000313375.3	-	12	1903	c.1856C>T	c.(1855-1857)tCc>tTc	p.S619F	MLXIPL_ENST00000414749.2_Missense_Mutation_p.S619F|MLXIPL_ENST00000429400.2_Missense_Mutation_p.S619F|MLXIPL_ENST00000395189.1_Missense_Mutation_p.S526F|MLXIPL_ENST00000354613.1_Missense_Mutation_p.S619F|MLXIPL_ENST00000434326.1_Missense_Mutation_p.S525F	NM_032951.2|NM_032953.2	NP_116569.1|NP_116571.1	Q9NP71	WBS14_HUMAN	MLX interacting protein-like	619					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			cervix(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	13		Lung NSC(55;0.0659)|all_lung(88;0.152)				GCCTGGCATGGAGCTGAGGTC	0.657000													16	34					0	0	1	0	0
PDPR	55066	broad.mit.edu	37	16	70190628	70190628	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:70190628T>G	ENST00000288050.4	+	19	3443	c.2486T>G	c.(2485-2487)gTg>gGg	p.V829G	PDPR_ENST00000568530.1_Missense_Mutation_p.V829G|RP11-296I10.3_ENST00000566989.1_RNA|PDPR_ENST00000542659.1_Missense_Mutation_p.V174G|PDPR_ENST00000567046.1_Missense_Mutation_p.V187G|PDPR_ENST00000398122.3_Missense_Mutation_p.V729G|PDPR_ENST00000562100.1_3'UTR	NM_017990.3	NP_060460.4	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory subunit	829					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|skin(2)|stomach(3)	33				BRCA - Breast invasive adenocarcinoma(221;0.124)		GAAGAGCAAGTGGTGACAGCA	0.567000													16	50					0	0	1	0	0
SERPINB11	89778	broad.mit.edu	37	18	61388181	61388181	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:61388181G>A	ENST00000544088.1	+	0	797				SERPINB11_ENST00000382749.5_RNA|SERPINB11_ENST00000538847.1_RNA|SERPINB11_ENST00000536691.1_RNA	NM_080475.2	NP_536723.2	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|kidney(1)|lung(3)	6		Esophageal squamous(42;0.129)				AATTAAGCATGATTATTCTGC	0.373000													3	9					0	0	1	0	0
EEF1DP3	196549	broad.mit.edu	37	13	32527418	32527418	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:32527418G>A	ENST00000428783.1	+	0	1118																											GGACAAGGTGGGGACAGACTT	0.582000													29	30					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32134659	32134659	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:32134659C>T	ENST00000312561.4	+	4	1184	c.770C>T	c.(769-771)cCa>cTa	p.P257L	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		TTAACTTTACCATCAAGGCAG	0.393000													20	36					0	0	1	0	0
SWT1	54823	broad.mit.edu	37	1	185153439	185153439	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:185153439C>T	ENST00000367500.4	+	8	1368	c.1203C>T	c.(1201-1203)ctC>ctT	p.L401L	SWT1_ENST00000367501.3_Silent_p.L401L	NM_017673.6	NP_060143.4	Q5T5J6	SWT1_HUMAN	SWT1 RNA endoribonuclease homolog (S. cerevisiae)	401	PINc.									breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(16)|ovary(1)|prostate(1)|urinary_tract(1)	41						TGAATCATCTCAAATTTGTTA	0.269000													7	13					0	0	1	0	0
MEP1A	4224	broad.mit.edu	37	6	46806849	46806849	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:46806849C>T	ENST00000230588.4	+	14	2226	c.2217C>T	c.(2215-2217)atC>atT	p.I739I		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	739					digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			TCATCGCCATCCTTTCCCAAA	0.597000													27	42					0	0	1	0	0
PJA1	64219	broad.mit.edu	37	X	68382856	68382856	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:68382856G>A	ENST00000361478.1	-	2	603	c.226C>T	c.(226-228)Cgt>Tgt	p.R76C	PJA1_ENST00000374584.3_Missense_Mutation_p.R76C|PJA1_ENST00000374583.1_Missense_Mutation_p.R76C|PJA1_ENST00000477231.1_5'UTR|PJA1_ENST00000374571.4_Missense_Mutation_p.R21C	NM_001032396.2|NM_022368.4|NM_145119.3	NP_001027568.1|NP_071763.2|NP_660095.1	Q8NG27	PJA1_HUMAN	praja ring finger 1, E3 ubiquitin protein ligase	76							zinc ion binding			endometrium(3)|large_intestine(5)|lung(12)|ovary(1)	21						CAACTACGACGAGTAGTGGAA	0.517000													45	49					0	0	1	0	0
TUBA1A	7846	broad.mit.edu	37	12	49579070	49579070	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:49579070G>A	ENST00000301071.7	-	4	1423	c.1079C>T	c.(1078-1080)cCc>cTc	p.P360L	TUBA1A_ENST00000550767.1_Missense_Mutation_p.P325L|TUBA1A_ENST00000295766.5_Missense_Mutation_p.P360L	NM_001270400.1|NM_006009.3	NP_001257329.1|NP_006000.2	Q71U36	TBA1A_HUMAN	tubulin, alpha 1a	360					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|structural molecule activity			stomach(1)|upper_aerodigestive_tract(1)	2						CACCACAGTGGGAGGCTGGTA	0.577000													13	16					0	0	1	0	0
ZIM2	23619	broad.mit.edu	37	19	57286272	57286272	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:57286272C>T	ENST00000391708.3	-	12	1910	c.1368G>A	c.(1366-1368)cgG>cgA	p.R456R	ZIM2_ENST00000601070.1_Silent_p.R456R|ZIM2_ENST00000221722.5_Silent_p.R456R|AC006115.3_ENST00000597946.1_RNA|AC006115.3_ENST00000595954.1_RNA|ZIM2_ENST00000593711.1_Silent_p.R456R|ZIM2_ENST00000599935.1_Silent_p.R456R|AC006115.3_ENST00000594400.1_RNA	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		AGTCATGTTTCCGCTGATAAC	0.463000													8	12					0	0	1	0	0
PDILT	204474	broad.mit.edu	37	16	20380937	20380937	+	Silent	SNP	G	G	A	rs144874720		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:20380937G>A	ENST00000302451.4	-	8	1241	c.993C>T	c.(991-993)gtC>gtT	p.V331V		NM_174924.1	NP_777584.1	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis expressed	331					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(13)|liver(1)|lung(33)|prostate(3)|skin(1)|urinary_tract(1)	61						ATGGGATATCGACCTCTGTGA	0.468000													33	56					0	0	1	0	0
NWD1	284434	broad.mit.edu	37	19	16860808	16860808	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:16860808C>T	ENST00000524140.2	+	6	1773	c.1355C>T	c.(1354-1356)cCc>cTc	p.P452L	NWD1_ENST00000552788.1_Missense_Mutation_p.P452L|NWD1_ENST00000549814.1_Missense_Mutation_p.P452L|NWD1_ENST00000379808.3_Missense_Mutation_p.P452L|NWD1_ENST00000339803.6_Missense_Mutation_p.P317L|NWD1_ENST00000523826.1_Missense_Mutation_p.P246L	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	452	NACHT.						ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CGGAGGGTTCCCTGGCTGCCT	0.617000													21	48					0	0	1	0	0
U47924.28	0	broad.mit.edu	37	12	7080017	7080017	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:7080017G>A	ENST00000261406.6	+	0	74																											CAGCCGGAAGGAAATTTGTGA	0.542000													2	0					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61833786	61833786	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:61833786C>T	ENST00000280772.1	-	37	7044	c.6853G>A	c.(6853-6855)Gat>Aat	p.D2285N	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	2285					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TTGGAAGGATCCCGCCCGGAC	0.488000													45	16					0	0	1	0	0
AKT1S1	84335	broad.mit.edu	37	19	50374934	50374934	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:50374934G>A	ENST00000391833.1	-	3	2486	c.497C>T	c.(496-498)aCc>aTc	p.T166I	AKT1S1_ENST00000391832.3_Missense_Mutation_p.T166I|AKT1S1_ENST00000391835.1_Missense_Mutation_p.T186I|AKT1S1_ENST00000391831.1_Missense_Mutation_p.T166I|AKT1S1_ENST00000344175.5_Missense_Mutation_p.T166I|AKT1S1_ENST00000391834.2_Missense_Mutation_p.T166I	NM_001278160.1	NP_001265089.1	Q96B36	AKTS1_HUMAN	AKT1 substrate 1 (proline-rich)	166					negative regulation of cell size|negative regulation of protein kinase activity|negative regulation of TOR signaling cascade|nerve growth factor receptor signaling pathway|neuroprotection|phosphatidylinositol-mediated signaling|regulation of survival gene product expression	cytosolic part	protein binding			kidney(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	5		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.0116)|OV - Ovarian serous cystadenocarcinoma(262;0.0132)		CACTGAGCAGGTGGGGGGGCC	0.652000													33	36					0	0	1	0	0
FBLN2	2199	broad.mit.edu	37	3	13612411	13612411	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:13612411G>A	ENST00000404922.3	+	2	675	c.556G>A	c.(556-558)Gag>Aag	p.E186K	FBLN2_ENST00000492059.1_Missense_Mutation_p.E186K|FBLN2_ENST00000295760.7_Missense_Mutation_p.E186K|FBLN2_ENST00000535798.1_Missense_Mutation_p.E212K	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	186	N.|Subdomain NB (Cys-free).					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			AGATGCCGAGGAGGGTGACCC	0.672000													6	16					0	0	1	0	0
SLX4	84464	broad.mit.edu	37	16	3640456	3640456	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:3640456G>A	ENST00000294008.3	-	12	3823	c.3183C>T	c.(3181-3183)tcC>tcT	p.S1061S		NM_032444.2	NP_115820.2	Q8IY92	SLX4_HUMAN	SLX4 structure-specific endonuclease subunit	1061	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding			breast(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	76						TTCCGCCACGGGACCGGGGTG	0.637000								Direct reversal of damage					36	74					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57325756	57325756	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:57325756C>T	ENST00000326441.9	-	10	4417	c.4054G>A	c.(4054-4056)Gag>Aag	p.E1352K	PEG3_ENST00000423103.2_Missense_Mutation_p.E1352K|PEG3_ENST00000598410.1_Missense_Mutation_p.E1228K|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000221722.5_Intron|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.E1226K|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000391708.3_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1352	Glu-rich.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AGATGAAGCTCCTTATGTTTA	0.448000													19	17					0	0	1	0	0
KIAA0226	9711	broad.mit.edu	37	3	197408089	197408089	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:197408089G>A	ENST00000273582.5	-	17	2751	c.2206C>T	c.(2206-2208)Ctc>Ttc	p.L736F	KIAA0226_ENST00000389665.5_Missense_Mutation_p.L806F|KIAA0226_ENST00000296343.5_Missense_Mutation_p.L781F	NM_001145642.2	NP_001139114.1	Q92622	RUBIC_HUMAN	KIAA0226	781					autophagy|endocytosis|negative regulation of autophagy|negative regulation of endocytosis	early endosome|late endosome|lysosome	protein binding			NS(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(143;8.26e-10)|Ovarian(172;0.0418)|Breast(254;0.0976)		Epithelial(36;2.19e-23)|all cancers(36;1.39e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.21e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(93;0.0446)		ATCTTAATGAGCAGGTCCTTG	0.527000													27	57					0	0	1	0	0
PPIC	5480	broad.mit.edu	37	5	122359606	122359606	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:122359606C>T	ENST00000306442.4	-	5	718	c.603G>A	c.(601-603)gtG>gtA	p.V201V		NM_000943.4	NP_000934.1	P45877	PPIC_HUMAN	peptidylprolyl isomerase C (cyclophilin C)	201					protein folding|signal transduction	cytoplasm	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	6		all_cancers(142;0.0168)|Prostate(80;0.0322)|Lung NSC(810;0.102)|all_lung(232;0.163)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000331)|Epithelial(69;0.000553)|all cancers(49;0.00505)	L-Proline(DB00172)	AAGGCGTTTTCACGTCTATCT	0.507000													44	70					0	0	1	0	0
PAM	5066	broad.mit.edu	37	5	102326039	102326039	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:102326039G>A	ENST00000438793.3	+	15	2017	c.1547G>A	c.(1546-1548)gGg>gAg	p.G516E	PAM_ENST00000455264.2_Missense_Mutation_p.G516E|PAM_ENST00000348126.2_Missense_Mutation_p.G409E|PAM_ENST00000346918.2_Missense_Mutation_p.G516E|PAM_ENST00000379787.4_5'UTR|PAM_ENST00000274392.9_Missense_Mutation_p.G419E|PAM_ENST00000304400.7_Missense_Mutation_p.G516E	NM_000919.3|NM_001177306.1|NM_138766.2	NP_000910.2|NP_001170777.1|NP_620121.1	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	516	Peptidyl-alpha-hydroxyglycine alpha- amidating lyase (By similarity).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding			endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	25		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	CAGGTTTCTGGGGTGGCTCTA	0.408000													10	14					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76557804	76557804	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:76557804C>T	ENST00000389840.5	-	12	1952	c.1828G>A	c.(1828-1830)Gaa>Aaa	p.E610K	DNAH17_ENST00000585328.1_Missense_Mutation_p.E610K					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CACGGGTGTTCGACGTGCTTC	0.647000													8	10					0	0	1	0	0
KIAA1407	57577	broad.mit.edu	37	3	113723520	113723520	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:113723520G>A	ENST00000295878.3	-	11	2088	c.1942C>T	c.(1942-1944)Cca>Tca	p.P648S	KIAA1407_ENST00000545063.1_Missense_Mutation_p.P479S	NM_020817.1	NP_065868.1	Q8NCU4	K1407_HUMAN	KIAA1407	648										endometrium(9)|large_intestine(7)|lung(19)|ovary(2)|pancreas(1)|prostate(1)|urinary_tract(1)	40						AATTGCTTTGGTTTCCTTCTG	0.463000													44	75					0	0	1	0	0
ELSPBP1	64100	broad.mit.edu	37	19	48522991	48522991	+	Missense_Mutation	SNP	C	C	T	rs139657764		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:48522991C>T	ENST00000339841.2	+	5	549	c.371C>T	c.(370-372)tCt>tTt	p.S124F	ELSPBP1_ENST00000597519.1_Intron	NM_022142.4	NP_071425.3	Q96BH3	ESPB1_HUMAN	epididymal sperm binding protein 1	124	Fibronectin type-II 3.				single fertilization	extracellular region				NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(6)	10		all_cancers(25;8.7e-09)|all_lung(116;1.15e-06)|all_epithelial(76;1.17e-06)|Lung NSC(112;2.56e-06)|all_neural(266;0.0138)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000253)|all cancers(93;0.00129)|Epithelial(262;0.0314)|GBM - Glioblastoma multiforme(486;0.0606)		GGGGGAAATTCTCTCAGGAAG	0.463000													14	21					0	0	1	0	0
LPAL2	80350	broad.mit.edu	37	6	160906968	160906968	+	RNA	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:160906968G>A	ENST00000335388.5	-	0	728					NR_028092.1															large_intestine(1)|lung(4)	5		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.214)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)		CCATTTCCATGGTAGCACTCC	0.453000													46	25					0	0	1	0	0
HERC2	8924	broad.mit.edu	37	15	28502252	28502252	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:28502252C>T	ENST00000261609.7	-	17	2580	c.2472G>A	c.(2470-2472)gaG>gaA	p.E824E		NM_004667.5	NP_004658.3	O95714	HERC2_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 2	824					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(3)|cervix(3)|endometrium(20)|kidney(11)|large_intestine(33)|lung(95)|ovary(7)|prostate(8)|skin(7)|upper_aerodigestive_tract(8)|urinary_tract(4)	204		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		CACACTCTTTCTCCTGGGGCG	0.522000													19	30					0	0	1	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68777091	68777091	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:68777091C>T	ENST00000508048.1	-	10	1258	c.1223G>A	c.(1222-1224)cGa>cAa	p.R408Q	TMPRSS11A_ENST00000334830.7_Missense_Mutation_p.R412Q|RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11A_ENST00000396188.2_Missense_Mutation_p.R409Q			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	412	Peptidase S1.				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						AATCCAGTTTCGGTAATAAGT	0.378000													27	41					0	0	1	0	0
PCDH8	5100	broad.mit.edu	37	13	53420335	53420335	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:53420335C>T	ENST00000377942.3	-	1	2440	c.2237G>A	c.(2236-2238)tGg>tAg	p.W746*	PCDH8_ENST00000338862.4_Nonsense_Mutation_p.W746*	NM_002590.3	NP_002581.2	O95206	PCDH8_HUMAN	protocadherin 8	746					cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(23)|ovary(1)|skin(1)|urinary_tract(1)	36		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CGGCGTGTCCCATTGCAGCAC	0.721000													6	59					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21427487	21427487	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:21427487C>T	ENST00000313654.9	+	32	4232	c.3991C>T	c.(3991-3993)Cgc>Tgc	p.R1331C	LAMA3_ENST00000399516.3_Missense_Mutation_p.R1331C	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	1331	Domain III B.|Laminin EGF-like 10.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTGCCCTCCCCGCACGGTCAG	0.617000													20	34					0	0	1	0	0
FAM47C	442444	broad.mit.edu	37	X	37028726	37028726	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:37028726C>T	ENST00000358047.3	+	1	2295	c.2243C>T	c.(2242-2244)tCc>tTc	p.S748F		NM_001013736.2	NP_001013758.1	Q5HY64	FA47C_HUMAN	family with sequence similarity 47, member C	748										breast(4)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(15)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	120						CCTCGGGTTTCCAGTCTCCGC	0.632000													28	42					0	0	1	0	0
MAGEB2	4113	broad.mit.edu	37	X	30236701	30236701	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:30236701C>T	ENST00000378988.4	+	2	105	c.4C>T	c.(4-6)Cct>Tct	p.P2S		NM_002364.4	NP_002355.2	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	2							protein binding			breast(1)|large_intestine(3)|lung(17)|ovary(1)|skin(1)	23						AGCCATCATGCCTCGTGGTCA	0.527000													4	17					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12856083	12856083	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:12856083A>C	ENST00000332296.7	+	4	1466	c.1363A>C	c.(1363-1365)Acc>Ccc	p.T455P	PRAMEF1_ENST00000400814.3_Missense_Mutation_p.T210P	NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	455										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		CATTGGCCCCACCCCCTGCCC	0.562000													19	133					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113529312	113529312	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:113529312A>C	ENST00000297405.5	-	28	4951	c.4707T>G	c.(4705-4707)atT>atG	p.I1569M	CSMD3_ENST00000352409.3_Missense_Mutation_p.I1569M|CSMD3_ENST00000343508.3_Missense_Mutation_p.I1529M|CSMD3_ENST00000455883.2_Missense_Mutation_p.I1465M	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1569	Sushi 8.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TTTCTACCTGAATGCAGGTTA	0.393000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	31					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144990870	144990870	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:144990870G>A	ENST00000322810.4	-	32	13699	c.13530C>T	c.(13528-13530)gcC>gcT	p.A4510A	PLEC_ENST00000527096.1_Silent_p.A4396A|PLEC_ENST00000398774.2_Silent_p.A4341A|PLEC_ENST00000356346.3_Silent_p.A4359A|PLEC_ENST00000354589.3_Silent_p.A4373A|PLEC_ENST00000354958.2_Silent_p.A4351A|PLEC_ENST00000357649.2_Silent_p.A4377A|PLEC_ENST00000345136.3_Silent_p.A4373A|PLEC_ENST00000436759.2_Silent_p.A4400A	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4510	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CCTTCTTCAGGGCCTGGGCGG	0.662000													15	34					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40135965	40135965	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:40135965C>T	ENST00000278198.2	-	2	3841	c.1878G>A	c.(1876-1878)ttG>ttA	p.L626L	LRRC4C_ENST00000530763.1_Silent_p.L626L|LRRC4C_ENST00000527150.1_Silent_p.L626L|LRRC4C_ENST00000528697.1_Silent_p.L626L			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	626					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				TCATTCGGATCAATAACGGTT	0.308000													22	21					0	0	1	0	0
MAPK15	225689	broad.mit.edu	37	8	144803839	144803839	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:144803839C>T	ENST00000338033.4	+	12	1444	c.1325C>T	c.(1324-1326)tCg>tTg	p.S442L		NM_139021.2	NP_620590.2	Q8TD08	MK15_HUMAN	mitogen-activated protein kinase 15	442					protein autophosphorylation	extracellular region	ATP binding|MAP kinase activity|SH3 domain binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|stomach(1)	12	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			TTGACACTCTCGCTGGTAAGT	0.637000													21	48					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14803054	14803054	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:14803054G>A	ENST00000253697.3	+	15	2879	c.2427G>A	c.(2425-2427)ctG>ctA	p.L809L	C3orf20_ENST00000435614.1_Silent_p.L687L|C3orf20_ENST00000412910.1_Silent_p.L687L	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	809						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						AGAATCTGCTGAAACAGATCT	0.488000													16	27					0	0	1	0	0
AMBRA1	55626	broad.mit.edu	37	11	46567197	46567197	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:46567197G>A	ENST00000458649.2	-	5	926	c.508C>T	c.(508-510)Ccc>Tcc	p.P170S	AMBRA1_ENST00000426438.1_Missense_Mutation_p.P170S|AMBRA1_ENST00000533727.1_Missense_Mutation_p.P170S|AMBRA1_ENST00000314845.3_Missense_Mutation_p.P170S|AMBRA1_ENST00000528950.1_Missense_Mutation_p.P170S|AMBRA1_ENST00000534300.1_Missense_Mutation_p.P170S|AMBRA1_ENST00000298834.3_Missense_Mutation_p.P170S			Q9C0C7	AMRA1_HUMAN	autophagy/beclin-1 regulator 1	170					autophagy|cell differentiation|nervous system development	autophagic vacuole|cytoplasmic vesicle				NS(1)|breast(3)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	39				GBM - Glioblastoma multiforme(35;0.0435)|Lung(87;0.182)		ACAGCAAAGGGTTCCCGTCGA	0.562000													27	32					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8331620	8331620	+	Silent	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:8331620T>C	ENST00000381196.4	-	41	6039	c.5496A>G	c.(5494-5496)gaA>gaG	p.E1832E	PTPRD_ENST00000486161.1_Silent_p.E1425E|PTPRD_ENST00000540109.1_Silent_p.E1832E|PTPRD_ENST00000358503.5_Silent_p.E1810E|PTPRD_ENST00000397606.3_Silent_p.E1425E|PTPRD_ENST00000355233.5_Silent_p.E1426E|PTPRD_ENST00000356435.5_Silent_p.E1832E|PTPRD_ENST00000397611.3_Silent_p.E1422E|PTPRD_ENST00000397617.3_Silent_p.E1425E|PTPRD_ENST00000537002.1_Silent_p.E1422E|PTPRD_ENST00000360074.4_Silent_p.E1819E	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1832	Tyrosine-protein phosphatase 2.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGCCAAACTGTTCTTTTGTTT	0.438000										TSP Lung(15;0.13)			25	41					0	0	1	0	0
GPRIN1	114787	broad.mit.edu	37	5	176024766	176024766	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:176024766G>A	ENST00000303991.4	-	2	2247	c.2070C>T	c.(2068-2070)tcC>tcT	p.S690S		NM_052899.2	NP_443131.2	Q7Z2K8	GRIN1_HUMAN	G protein regulated inducer of neurite outgrowth 1	690						growth cone|plasma membrane				NS(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTTTCCCCAGGGACACAGGCT	0.577000													20	23					0	0	1	0	0
DAGLB	221955	broad.mit.edu	37	7	6476165	6476165	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:6476165C>T	ENST00000297056.6	-	3	417		c.e3-1		DAGLB_ENST00000425398.2_Splice_Site|DAGLB_ENST00000428902.2_Intron|DAGLB_ENST00000479922.2_Splice_Site|DAGLB_ENST00000436575.1_Splice_Site|DAGLB_ENST00000421761.2_Intron	NM_139179.3	NP_631918.3	Q8NCG7	DGLB_HUMAN	diacylglycerol lipase, beta						lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(3)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|urinary_tract(2)	26		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.102)		CAAATCGTTCCTGAAATACAA	0.473000													20	16					0	0	1	0	0
FBXL16	146330	broad.mit.edu	37	16	746973	746973	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:746973C>T	ENST00000397621.1	-	2	764	c.433G>A	c.(433-435)Gag>Aag	p.E145K	FBXL16_ENST00000324361.5_Missense_Mutation_p.E145K	NM_153350.3	NP_699181.2	Q8N461	FXL16_HUMAN	F-box and leucine-rich repeat protein 16	145										endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(3)|ovary(1)	10		Hepatocellular(780;0.0218)				TTGTAGAGCTCCTTGGCATGC	0.642000													17	26					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77767140	77767140	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:77767140G>A	ENST00000521891.2	+	10	8431	c.7983G>A	c.(7981-7983)agG>agA	p.R2661R	ZFHX4_ENST00000518282.1_Silent_p.R2635R|ZFHX4_ENST00000050961.6_Silent_p.R2616R|ZFHX4_ENST00000455469.2_Silent_p.R2616R	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2616						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CGCGGGAGAGGAAAGGCCAGT	0.527000										HNSCC(33;0.089)			19	33					0	0	1	0	0
ARHGAP35	2909	broad.mit.edu	37	19	47425236	47425236	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:47425236G>A	ENST00000404338.3	+	1	3304	c.3304G>A	c.(3304-3306)Gaa>Aaa	p.E1102K		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	1102					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity	p.E1102Q(1)									GAATGAAGAAGAAAACATATA	0.502000													10	16					0	0	1	0	0
IGHV3-53	28420	broad.mit.edu	37	14	107048861	107048861	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:107048861C>T	ENST00000390627.2	-	0	379																											GGACCCAGCTCATGTAGTTGC	0.592000													29	131					0	0	1	0	0
GLIS1	148979	broad.mit.edu	37	1	53975559	53975559	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:53975559G>A	ENST00000312233.2	-	8	2066	c.1500C>T	c.(1498-1500)ttC>ttT	p.F500F		NM_147193.2	NP_671726.2	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	500	Pro-rich.				negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(3)|urinary_tract(4)	24						GAGGGCTCTGGAAGGGTGGGT	0.692000													3	4					0	0	1	0	0
DIRAS2	54769	broad.mit.edu	37	9	93375880	93375880	+	Missense_Mutation	SNP	G	G	A	rs71494416		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:93375880G>A	ENST00000375765.3	-	2	618	c.230C>T	c.(229-231)tCc>tTc	p.S77F		NM_017594.3	NP_060064.2	Q96HU8	DIRA2_HUMAN	DIRAS family, GTP-binding RAS-like 2	77					small GTPase mediated signal transduction	intracellular|plasma membrane	GTP binding|GTPase activity			kidney(1)|large_intestine(6)|lung(3)|skin(2)	12						GTGCCCTTTGGAGATGGACAG	0.562000													40	21					0	0	1	0	0
A2M	2	broad.mit.edu	37	12	9262613	9262613	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:9262613T>A	ENST00000318602.7	-	6	830	c.523A>T	c.(523-525)Atc>Ttc	p.I175F		NM_000014.4	NP_000005.2	P01023	A2MG_HUMAN	alpha-2-macroglobulin	175					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(17)|lung(30)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	77					Bacitracin(DB00626)|Becaplermin(DB00102)	CATTGTGCGATGCGATTTCCT	0.428000													25	43					0	0	1	0	0
VSTM2A	222008	broad.mit.edu	37	7	54612452	54612452	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:54612452G>A	ENST00000302287.3	+	2	623	c.217G>A	c.(217-219)Gat>Aat	p.D73N	VSTM2A_ENST00000402026.2_Missense_Mutation_p.D72N|VSTM2A_ENST00000404951.1_Missense_Mutation_p.D73N|VSTM2A_ENST00000407838.3_Missense_Mutation_p.D73N|VSTM2A_ENST00000402613.3_Missense_Mutation_p.D73N			Q8TAG5	VTM2A_HUMAN	V-set and transmembrane domain containing 2A	73	Ig-like V-type.					extracellular region				endometrium(1)|large_intestine(2)|lung(12)|prostate(1)	16			STAD - Stomach adenocarcinoma(5;0.0525)			GGAGGACCTGGATCCCGGGGC	0.731000													7	13					0	0	1	0	0
SLC38A8	146167	broad.mit.edu	37	16	84043400	84043400	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:84043400C>T	ENST00000299709.3	-	10	1296	c.1297G>A	c.(1297-1299)Gag>Aag	p.E433K		NM_001080442.1	NP_001073911.1	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	433					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						CAGAACATCTCCCAGACCGCT	0.622000													11	18					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12364662	12364662	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:12364662T>C	ENST00000358136.3	+	26	6446	c.6316T>C	c.(6316-6318)Ttc>Ctc	p.F2106L	VPS13D_ENST00000356315.4_Missense_Mutation_p.F2106L	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	2106					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		CCAGGGGCAGTTCACGATGCC	0.567000													20	22					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77398163	77398163	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:77398163G>A	ENST00000282849.5	-	5	1312	c.894C>T	c.(892-894)ctC>ctT	p.L298L		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	298	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						CTGCCACCACGAGGGTTTCCA	0.483000													11	14					0	0	1	0	0
SGMS2	166929	broad.mit.edu	37	4	108816868	108816868	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:108816868C>T	ENST00000394684.4	+	3	716	c.159C>T	c.(157-159)acC>acT	p.T53T	SGMS2_ENST00000394686.3_Silent_p.T53T|RP11-286E11.1_ENST00000499098.1_RNA|SGMS2_ENST00000359079.4_Silent_p.T53T|RP11-286E11.1_ENST00000513071.1_RNA	NM_001136258.1	NP_001129730.1	Q8NHU3	SMS2_HUMAN	sphingomyelin synthase 2	53					sphingomyelin biosynthetic process	integral to Golgi membrane|integral to plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			central_nervous_system(1)|endometrium(2)|large_intestine(8)|liver(2)|lung(6)|prostate(1)	20				OV - Ovarian serous cystadenocarcinoma(123;2.95e-05)	Choline(DB00122)	GAAAAGGCACCAAAAAGTACC	0.443000													13	25					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152279850	152279850	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:152279850G>A	ENST00000368799.1	-	3	7547	c.7512C>T	c.(7510-7512)tcC>tcT	p.S2504S	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2504	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTGCCCATGGGAGGCATCAG	0.547000									Ichthyosis				148	172					0	0	1	0	0
PTGER3	5733	broad.mit.edu	37	1	71318529	71318529	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:71318529C>T	ENST00000370932.2	-	3	1321	c.1091G>A	c.(1090-1092)gGa>gAa	p.G364E	PTGER3_ENST00000370931.3_3'UTR|PTGER3_ENST00000351052.5_3'UTR|PTGER3_ENST00000460330.1_Missense_Mutation_p.G373E	NM_198717.1	NP_942010.1	P43115	PE2R3_HUMAN	prostaglandin E receptor 3 (subtype EP3)	364					cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			endometrium(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25					Bimatoprost(DB00905)	GTTTTAATTTCCCCAAAATTC	0.338000													42	78					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21487526	21487526	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:21487526C>T	ENST00000313654.9	+	53	6972	c.6731C>T	c.(6730-6732)gCt>gTt	p.A2244V	LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000587184.1_Missense_Mutation_p.A579V|LAMA3_ENST00000399516.3_Missense_Mutation_p.A2188V|LAMA3_ENST00000269217.6_Missense_Mutation_p.A635V	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2244	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTCAGTCCAGCTCTCAACAAC	0.423000													23	57					0	0	1	0	0
NSUN2	54888	broad.mit.edu	37	5	6611115	6611115	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:6611115G>A	ENST00000264670.6	-	11	1490	c.1179C>T	c.(1177-1179)ttC>ttT	p.F393F	NSUN2_ENST00000506139.1_Silent_p.F358F|NSUN2_ENST00000539938.1_Silent_p.F157F	NM_017755.5	NP_060225.4	Q08J23	NSUN2_HUMAN	NOP2/Sun RNA methyltransferase family, member 2	393						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(23)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	41						CCTTCGGAGGGAACATGGTAG	0.592000													16	31					0	0	1	0	0
SPTBN5	51332	broad.mit.edu	37	15	42154373	42154373	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:42154373G>A	ENST00000320955.6	-	44	7730	c.7503C>T	c.(7501-7503)agC>agT	p.S2501S		NM_016642.2	NP_057726.4	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	2501					actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				NS(1)|breast(1)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(6)|lung(18)|ovary(5)|prostate(8)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	62		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		CTTCCACAGGGCTGCGAGGAG	0.627000													3	8					0	0	1	0	0
VPS33A	65082	broad.mit.edu	37	12	122729244	122729244	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:122729244G>A	ENST00000267199.4	-	7	953	c.841C>T	c.(841-843)Ccc>Tcc	p.P281S	RP11-512M8.5_ENST00000535844.1_Missense_Mutation_p.P242S	NM_022916.4	NP_075067.2	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33 homolog A (S. cerevisiae)	281					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	28	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		GCTTCCGTGGGGAGGTCCTTA	0.493000													23	24					0	0	1	0	0
IL17B	27190	broad.mit.edu	37	5	148754101	148754101	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:148754101C>T	ENST00000261796.3	-	3	424	c.374G>A	c.(373-375)gGc>gAc	p.G125D	RP11-394O4.3_ENST00000521756.1_RNA|IL17B_ENST00000505432.1_5'UTR	NM_014443.2	NP_055258.1	Q9UHF5	IL17B_HUMAN	interleukin 17B	125					cell-cell signaling|immune response|inflammatory response	extracellular space	cytokine activity|signal transducer activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|lung(3)|prostate(1)|urinary_tract(1)	8			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTCACACAGCCCAGACACAG	0.662000													29	33					0	0	1	0	0
PRDM16	63976	broad.mit.edu	37	1	3328996	3328996	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:3328996C>T	ENST00000378398.3	+	10	2320	c.2238C>T	c.(2236-2238)ctC>ctT	p.L746L	PRDM16_ENST00000514189.1_Silent_p.L746L|PRDM16_ENST00000511072.1_Silent_p.L746L|PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000442529.2_Silent_p.L745L|PRDM16_ENST00000441472.2_Silent_p.L745L|PRDM16_ENST00000378391.2_Silent_p.L745L|PRDM16_ENST00000270722.5_Silent_p.L745L			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	745	Interaction with CTBP1 and CTBP2 (By similarity).|Mediates interaction with SKI and regulation of TGF-beta signaling.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		ACCGAGCCCTCGCCCACAACT	0.647000			T	EVI1	"""MDS, AML"""								26	52					0	0	1	0	0
TM7SF3	51768	broad.mit.edu	37	12	27132718	27132718	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:27132718C>T	ENST00000343028.4	-	9	1413	c.1189_splice	c.e9+1	p.L396_splice		NM_016551.2	NP_057635.1	Q9NS93	TM7S3_HUMAN	transmembrane 7 superfamily member 3	396						integral to membrane|plasma membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	18	Colorectal(261;0.0847)					ATCGCCTACCCAGTGGAGTAA	0.473000													5	11					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100199436	100199436	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:100199436C>T	ENST00000317233.4	-	16	2852	c.2617G>A	c.(2617-2619)Gaa>Aaa	p.E873K	AFF3_ENST00000356421.2_Missense_Mutation_p.E898K|AFF3_ENST00000409236.1_Missense_Mutation_p.E873K|AFF3_ENST00000409579.1_Missense_Mutation_p.E898K	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	873					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						AGCATTTTTTCATTTTTATTT	0.413000													23	12					0	0	1	0	0
NANOGP1	404635	broad.mit.edu	37	12	8051405	8051405	+	RNA	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:8051405A>T	ENST00000607111.1	+	0	625																				kidney(1)|lung(4)|prostate(1)	6						GAAGGCCTTAATGTAATACAG	0.463000													7	57					0	0	1	0	0
KHDC1L	100129128	broad.mit.edu	37	6	73933975	73933975	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:73933975G>A	ENST00000370388.3	-	2	252	c.209C>T	c.(208-210)aCt>aTt	p.T70I	RP11-257K9.8_ENST00000423730.3_3'UTR	NM_001126063.2	NP_001119535.1	Q5JSQ8	KHDCL_HUMAN	KH homology domain containing 1-like	70										breast(1)|endometrium(1)|kidney(1)|lung(3)|skin(1)	7						TCCGACTACAGTCACACGTGT	0.552000													4	1					0	0	1	0	0
TLR3	7098	broad.mit.edu	37	4	187004844	187004844	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:187004844C>T	ENST00000296795.2	+	4	2108	c.2004C>T	c.(2002-2004)atC>atT	p.I668I	TLR3_ENST00000504367.1_Silent_p.I391I	NM_003265.2	NP_003256.1	O15455	TLR3_HUMAN	toll-like receptor 3	668	LRRCT.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(5)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	29		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		ATACCAACATCCCTGAGCTGT	0.453000													47	73					0	0	1	0	0
ZNF506	440515	broad.mit.edu	37	19	19906391	19906391	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:19906391C>T	ENST00000443905.2	-	4	452	c.305G>A	c.(304-306)aGa>aAa	p.R102K	CTC-559E9.6_ENST00000591884.1_RNA|ZNF506_ENST00000587461.1_Intron|ZNF506_ENST00000540806.2_Missense_Mutation_p.R102K|CTC-559E9.4_ENST00000590274.1_lincRNA|CTC-559E9.6_ENST00000589657.1_RNA|ZNF506_ENST00000450683.2_Missense_Mutation_p.R70K			Q5JVG8	ZN506_HUMAN	zinc finger protein 506	102					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(1)|endometrium(1)|large_intestine(7)|lung(3)|skin(1)|stomach(1)	14						TTTTTCATATCTTCTTAGTAT	0.328000													10	22					0	0	1	0	0
CHDC2	286464	broad.mit.edu	37	X	36162769	36162769	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:36162769G>A	ENST00000378660.1	+	11	1540	c.1352G>A	c.(1351-1353)cGa>cAa	p.R451Q	CHDC2_ENST00000313548.4_Missense_Mutation_p.R451Q					calponin homology domain containing 2																		gttaccatccgattggctgtg	0.443000													6	18					0	0	1	0	0
RAB3GAP2	25782	broad.mit.edu	37	1	220368696	220368696	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:220368696G>A	ENST00000358951.2	-	11	1100	c.984C>T	c.(982-984)tcC>tcT	p.S328S		NM_012414.3	NP_036546.2	Q9H2M9	RBGPR_HUMAN	RAB3 GTPase activating protein subunit 2 (non-catalytic)	328					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(131;0.0443)		GTGCAACATGGGATAATAATG	0.308000													26	38					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10951344	10951344	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr21:10951344G>A	ENST00000298232.7	-	9	681	c.314C>T	c.(313-315)cCt>cTt	p.P105L	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Missense_Mutation_p.P85L|TPTE_ENST00000361285.4_Missense_Mutation_p.P123L	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	123					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ATACTCCAAAGGAATATAAAG	0.323000													8	22					0	0	1	0	0
SORCS3	22986	broad.mit.edu	37	10	107015508	107015508	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:107015508G>A	ENST00000369701.3	+	24	3513	c.3286G>A	c.(3286-3288)Gag>Aag	p.E1096K		NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1096						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		GGTCCAGTTTGAGCTGAAGCC	0.458000													12	9					0	0	1	0	0
ABCA17P	650655	broad.mit.edu	37	16	2474740	2474740	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:2474740C>T	ENST00000469908.1	+	0	2909					NR_003574.1																						TGGAGGAGTTCAAGGCCTTCG	0.667000													4	11					0	0	1	0	0
ZNF76	7629	broad.mit.edu	37	6	35261549	35261549	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:35261549C>T	ENST00000373953.3	+	12	1617	c.1351C>T	c.(1351-1353)Ctg>Ttg	p.L451L	ZNF76_ENST00000339411.5_Intron|ZNF76_ENST00000440666.2_Silent_p.L425L	NM_003427.3	NP_003418.2	P36508	ZNF76_HUMAN	zinc finger protein 76	451					regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						CCCGGAAGACCTGCAGGCCCT	0.602000													25	52					0	0	1	0	0
RNF19B	127544	broad.mit.edu	37	1	33402703	33402703	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:33402703G>T	ENST00000373456.7	-	9	1902	c.1903C>A	c.(1903-1905)Ccc>Acc	p.P635T	RNF19B_ENST00000356990.5_3'UTR|RNF19B_ENST00000235150.4_Missense_Mutation_p.P634T	NM_153341.2	NP_699172.2	Q6ZMZ0	RN19B_HUMAN	ring finger protein 19B	635						integral to membrane	ligase activity|protein binding|zinc ion binding			endometrium(4)|kidney(2)|large_intestine(3)|lung(4)	13		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CTGCAGGGGGGATCCTCTTCA	0.567000													30	56					5.45727e-16	5.55595e-16	1	1	0
GNAO1	2775	broad.mit.edu	37	16	56374802	56374802	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:56374802C>T	ENST00000262494.7	+	7	1040	c.780C>T	c.(778-780)ttC>ttT	p.F260F	GNAO1_ENST00000262493.6_Intron	NM_138736.2	NP_620073.2	P09471	GNAO_HUMAN	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O	260					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)	17		all_neural(199;0.159)				ACAAATGGTTCACAGACACGT	0.483000													108	151					0	0	1	0	0
KIAA2022	340533	broad.mit.edu	37	X	73961741	73961741	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:73961741T>C	ENST00000373468.1	-	3	3302	c.2651A>G	c.(2650-2652)aAc>aGc	p.N884S	KIAA2022_ENST00000055682.5_Missense_Mutation_p.N884S			Q5QGS0	K2022_HUMAN	KIAA2022	884					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						ATTTCTATAGTTGCTTGATTC	0.488000													9	17					0	0	1	0	0
ZNF311	282890	broad.mit.edu	37	6	28962815	28962815	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:28962815G>A	ENST00000377179.3	-	7	2476	c.1964C>T	c.(1963-1965)tCt>tTt	p.S655F	ZNF311_ENST00000483450.1_5'UTR	NM_001010877.2	NP_001010877.2	Q5JNZ3	ZN311_HUMAN	zinc finger protein 311	655					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|skin(3)|upper_aerodigestive_tract(2)	28						TGAGGTCTGAGAAACAGTCAC	0.423000													9	10					0	0	1	0	0
ARMCX3	51566	broad.mit.edu	37	X	100880948	100880948	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:100880948C>T	ENST00000341189.4	+	5	1845	c.979C>T	c.(979-981)Caa>Taa	p.Q327*	ARMCX3_ENST00000537169.1_Nonsense_Mutation_p.Q327*|ARMCX3_ENST00000471229.2_Nonsense_Mutation_p.Q327*	NM_016607.3	NP_057691.1	Q9UH62	ARMX3_HUMAN	armadillo repeat containing, X-linked 3	327						integral to membrane	binding			endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)	11						TACTCAGAATCAATTCGGTGA	0.308000													26	40					0	0	1	0	0
C12orf56	115749	broad.mit.edu	37	12	64668686	64668686	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:64668686G>A	ENST00000543942.2	-	11	2205	c.1579C>T	c.(1579-1581)Ccc>Tcc	p.P527S	C12orf56_ENST00000536975.1_5'UTR|C12orf56_ENST00000333722.5_Missense_Mutation_p.P367S|RPS11P6_ENST00000535684.1_RNA	NM_001170633.1	NP_001164104.1	Q8IXR9	CL056_HUMAN	chromosome 12 open reading frame 56	530										NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)	15			GBM - Glioblastoma multiforme(3;0.000582)	GBM - Glioblastoma multiforme(28;0.0259)		CTTACGATGGGAGGACAGCTT	0.368000													25	22					0	0	1	0	0
FUT3	2525	broad.mit.edu	37	19	5844628	5844628	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:5844628G>A	ENST00000303225.6	-	3	857	c.223C>T	c.(223-225)Cct>Tct	p.P75S	FUT3_ENST00000589620.1_Missense_Mutation_p.P75S|FUT3_ENST00000589918.1_Missense_Mutation_p.P75S|FUT3_ENST00000458379.2_Missense_Mutation_p.P75S	NM_000149.3	NP_000140.1	P21217	FUT3_HUMAN	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)	75					protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|upper_aerodigestive_tract(1)	14						AGAGCCACAGGGATGTGGAAA	0.637000													32	35					0	0	1	0	0
IFT80	57560	broad.mit.edu	37	3	160099326	160099326	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:160099326G>A	ENST00000326448.7	-	3	656	c.224C>T	c.(223-225)aCc>aTc	p.T75I	IFT80_ENST00000477495.1_5'UTR|IFT80_ENST00000483465.1_5'UTR|RP11-432B6.3_ENST00000483754.1_Intron|IFT80_ENST00000496589.1_5'UTR	NM_020800.2	NP_065851.1	Q9P2H3	IFT80_HUMAN	intraflagellar transport 80 homolog (Chlamydomonas)	75						cilium axoneme|microtubule basal body				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(12)|lung(10)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	36			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TTCTGCCTGGGTTTGTTTCTT	0.323000													17	19					0	0	1	0	0
GPR174	84636	broad.mit.edu	37	X	78426738	78426738	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:78426738C>T	ENST00000276077.1	+	1	270	c.234C>T	c.(232-234)taC>taT	p.Y78Y		NM_032553.1	NP_115942.1	Q9BXC1	GP174_HUMAN	G protein-coupled receptor 174	78						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	38						GGATCTTCTACTACTTGAATC	0.398000										HNSCC(63;0.18)			10	13					0	0	1	0	0
MYO5C	55930	broad.mit.edu	37	15	52556396	52556396	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:52556396G>A	ENST00000261839.7	-	9	1199	c.1038C>T	c.(1036-1038)tcC>tcT	p.S346S	MYO5C_ENST00000443683.2_Silent_p.S289S|MYO5C_ENST00000541028.1_5'UTR	NM_018728.3	NP_061198.2	Q9NQX4	MYO5C_HUMAN	myosin VC	346	Myosin head-like.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(7)|large_intestine(15)|lung(12)|ovary(7)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66				all cancers(107;0.0137)		CACTAACTGAGGACCTCTCGT	0.473000													7	15					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69817407	69817407	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:69817407C>T	ENST00000251566.4	-	1	102	c.72G>A	c.(70-72)ggG>ggA	p.G24G		NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	24						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						CCAGGACTTTCCCACAGAATC	0.493000													17	32					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8639324	8639324	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:8639324G>A	ENST00000378641.3	+	9	1310	c.835G>A	c.(835-837)Gaa>Aaa	p.E279K	PLCB1_ENST00000338037.6_Missense_Mutation_p.E279K|PLCB1_ENST00000378637.2_Missense_Mutation_p.E279K	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	279					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						TGAGAAGTATGAACCCAACAA	0.433000													26	42					0	0	1	0	0
TSPAN18	90139	broad.mit.edu	37	11	44941443	44941443	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:44941443G>A	ENST00000340160.3	+	7	747	c.508G>A	c.(508-510)Gaa>Aaa	p.E170K	TSPAN18_ENST00000520358.2_Missense_Mutation_p.E170K	NM_130783.4	NP_570139.3	Q96SJ8	TSN18_HUMAN	tetraspanin 18	170						integral to membrane				endometrium(1)|large_intestine(6)|lung(3)	10						CCTGGATAGTGAAGAGGTGCC	0.587000													40	66					0	0	1	0	0
CYP2C8	1558	broad.mit.edu	37	10	96827404	96827404	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:96827404C>T	ENST00000371270.3	-	2	307	c.213G>A	c.(211-213)atG>atA	p.M71I	CYP2C8_ENST00000535898.1_Intron|CYP2C8_ENST00000539050.1_5'UTR	NM_000770.3|NM_001198853.1|NM_001198855.1	NP_000761.3|NP_001185782.1|NP_001185784.1	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 8	71					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|skin(3)	21		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	CTATGGGATTCATGCCAAAAT	0.413000													11	7					0	0	1	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85515512	85515512	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:85515512C>T	ENST00000393217.2	+	16	3476	c.3415C>T	c.(3415-3417)Ctc>Ttc	p.L1139F		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1139	LRRCT.									breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		TCTGAGAATCCTCAATGGCAA	0.378000													10	17					0	0	1	0	0
ARHGAP1	392	broad.mit.edu	37	11	46702863	46702863	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:46702863G>A	ENST00000311956.4	-	6	613	c.516C>T	c.(514-516)atC>atT	p.I172I		NM_004308.2	NP_004299.1	Q07960	RHG01_HUMAN	Rho GTPase activating protein 1	172	CRAL-TRIO.				Rho protein signal transduction	cytosol|intracellular membrane-bounded organelle	SH3 domain binding|SH3/SH2 adaptor activity			endometrium(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	11		Lung NSC(402;1.76e-12)|all_lung(304;1.3e-11)		GBM - Glioblastoma multiforme(35;5.17e-06)|BRCA - Breast invasive adenocarcinoma(625;0.00112)|Lung(87;0.153)		GCTTGAAGAGGATGAGCAGAG	0.567000													25	55					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179592998	179592998	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:179592998C>T	ENST00000589042.1	-	67	19777	c.19553G>A	c.(19552-19554)gGa>gAa	p.G6518E	TTN_ENST00000591111.1_Missense_Mutation_p.G6201E|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.G5274E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6201	Ig-like 46.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATTTCTTTTCCATCCTTAAA	0.368000													10	4					0	0	1	0	0
SRSF6	6431	broad.mit.edu	37	20	42089646	42089646	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:42089646C>T	ENST00000244020.3	+	6	1084	c.978C>T	c.(976-978)tcC>tcT	p.S326S		NM_006275.5	NP_006266.2	Q13247	SRSF6_HUMAN	serine/arginine-rich splicing factor 6	326	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|upper_aerodigestive_tract(2)	5						CTTCAAGATCCCGTTCTAGAT	0.488000													24	29					0	0	1	0	0
ARC	23237	broad.mit.edu	37	8	143694448	143694448	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:143694448G>A	ENST00000356613.2	-	1	2385	c.1185C>T	c.(1183-1185)ccC>ccT	p.P395P		NM_015193.3	NP_056008.1	Q7LC44	ARC_HUMAN	activity-regulated cytoskeleton-associated protein	395					endocytosis	acrosomal vesicle|cell junction|dendritic spine|endosome|postsynaptic density|postsynaptic membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(3)|upper_aerodigestive_tract(1)	13	all_cancers(97;3.55e-12)|all_epithelial(106;1.03e-08)|Lung NSC(106;0.000353)|all_lung(105;0.00092)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;0.0279)				CCCTCTACTCGGGCTGGGTCC	0.706000													2	2					0	0	1	0	0
CFHR2	3080	broad.mit.edu	37	1	196927044	196927044	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:196927044C>T	ENST00000367415.4	+	4	568	c.454C>T	c.(454-456)Cct>Tct	p.P152S	CFHR2_ENST00000367421.3_Missense_Mutation_p.P152S|CFHR2_ENST00000476712.1_3'UTR	NM_005666.2	NP_005657.1	P36980	FHR2_HUMAN	complement factor H-related 2	152	Sushi 3.					extracellular region				large_intestine(2)|ovary(1)|skin(3)	6						ATGTGGGCCCCCTCCACCTAT	0.383000													16	36					0	0	1	0	0
ZNF416	55659	broad.mit.edu	37	19	58084161	58084161	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:58084161G>A	ENST00000196489.3	-	4	1333	c.1111C>T	c.(1111-1113)Cga>Tga	p.R371*		NM_017879.1	NP_060349.1	Q9BWM5	ZN416_HUMAN	zinc finger protein 416	371					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|large_intestine(5)|lung(12)|prostate(1)	22		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0259)		CTCTGGTGTCGAACAAGAGTG	0.423000													17	30					0	0	1	0	0
ATXN10	25814	broad.mit.edu	37	22	46085648	46085648	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:46085648C>T	ENST00000252934.5	+	2	438	c.173C>T	c.(172-174)tCt>tTt	p.S58F	ATXN10_ENST00000498009.1_3'UTR|ATXN10_ENST00000381061.4_Intron	NM_013236.3	NP_037368.1	Q9UBB4	ATX10_HUMAN	ataxin 10	58					cell death|neuron projection development	dendrite|neuronal cell body|perinuclear region of cytoplasm				central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	10		Ovarian(80;0.00973)|all_neural(38;0.0417)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0223)		AAGAAATCTTCTCATGCTGTT	0.403000													21	41					0	0	1	0	0
HIRA	7290	broad.mit.edu	37	22	19319022	19319022	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:19319022G>A	ENST00000263208.5	-	25	3251	c.2995C>T	c.(2995-2997)Cga>Tga	p.R999*	HIRA_ENST00000541063.1_Nonsense_Mutation_p.R955*|HIRA_ENST00000340170.4_Nonsense_Mutation_p.R792*	NM_003325.3	NP_003316.3	P54198	HIRA_HUMAN	histone cell cycle regulator	999	Interaction with histone H4.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)|prostate(1)|skin(1)	37	Colorectal(54;0.0993)					CGCTGGAATCGGAGGTTCTGC	0.607000													24	31					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86512515	86512515	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:86512515C>T	ENST00000370571.2	-	12	2309	c.1943G>A	c.(1942-1944)gGg>gAg	p.G648E	COL24A1_ENST00000436319.1_Missense_Mutation_p.G648E	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	648					cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		TACCTGTCTCCCCTTAAAacc	0.313000													12	20					0	0	1	0	0
KRT31	3881	broad.mit.edu	37	17	39552819	39552819	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:39552819G>A	ENST00000251645.2	-	3	493	c.441C>T	c.(439-441)acC>acT	p.T147T		NM_002277.2	NP_002268.2	Q15323	K1H1_HUMAN	keratin 31	147	Coil 1B.|Rod.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(7)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	31		Breast(137;0.000496)				GGGACAGCTCGGTCTGGTACC	0.557000													29	27					0	0	1	0	0
LAMB4	22798	broad.mit.edu	37	7	107698335	107698335	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:107698335C>T	ENST00000388781.3	-	24	3404	c.3321G>A	c.(3319-3321)ggG>ggA	p.G1107G	LAMB4_ENST00000388780.3_Silent_p.G1107G|LAMB4_ENST00000205386.4_Silent_p.G1107G	NM_007356.2	NP_031382.2	A4D0S4	LAMB4_HUMAN	laminin, beta 4	1107	Laminin EGF-like 12.				cell adhesion	basement membrane				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(22)|lung(40)|ovary(4)|prostate(5)|skin(4)	97						TGCAACGTTTCCCGCCGTAAC	0.428000													12	13					0	0	1	0	0
TIMM8A	1678	broad.mit.edu	37	X	100601521	100601521	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:100601521G>A	ENST00000372902.3	-	2	791	c.260C>T	c.(259-261)tCc>tTc	p.S87F		NM_004085.3	NP_004076.1	O60220	TIM8A_HUMAN	translocase of inner mitochondrial membrane 8 homolog A (yeast)	87					nervous system development|protein import into mitochondrial inner membrane|transmembrane transport	mitochondrial inner membrane|mitochondrial intermembrane space protein transporter complex	protein binding			endometrium(1)|lung(1)	2						AACTGGCTTGGATTTCTGGGT	0.448000													56	105					0	0	1	0	0
FCRL4	83417	broad.mit.edu	37	1	157559020	157559020	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:157559020T>C	ENST00000271532.1	-	3	416	c.281A>G	c.(280-282)aAc>aGc	p.N94S	FCRL4_ENST00000448509.2_5'UTR	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4	94	Ig-like C2-type 1.					integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				GCGCACAGGGTTACTTCGTGG	0.498000													17	28					0	0	1	0	0
GRIA2	2891	broad.mit.edu	37	4	158238851	158238851	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:158238851C>T	ENST00000296526.7	+	5	1033	c.708C>T	c.(706-708)atC>atT	p.I236I	GRIA2_ENST00000449365.1_Silent_p.I189I|GRIA2_ENST00000393815.2_Silent_p.I189I|GRIA2_ENST00000264426.9_Silent_p.I236I|GRIA2_ENST00000507898.1_Silent_p.I189I	NM_000826.3	NP_000817.2	P42262	GRIA2_HUMAN	glutamate receptor, ionotropic, AMPA 2	236					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|endoplasmic reticulum membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(2)|lung(32)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	79	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0294)	L-Glutamic Acid(DB00142)	ACCACTACATCATTGCAAATC	0.249000													6	14					0	0	1	0	0
KIAA1210	57481	broad.mit.edu	37	X	118239074	118239074	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:118239074G>A	ENST00000402510.2	-	7	948	c.949C>T	c.(949-951)Cca>Tca	p.P317S		NM_020721.1	NP_065772.1	Q9ULL0	K1210_HUMAN	KIAA1210	317										breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(31)|ovary(4)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	64						ATAACAGGTGGGATGATGCTG	0.428000													41	40					0	0	1	0	0
TSKS	60385	broad.mit.edu	37	19	50248503	50248503	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:50248503C>T	ENST00000246801.3	-	7	1225	c.1143G>A	c.(1141-1143)cgG>cgA	p.R381R	TSKS_ENST00000358830.3_Silent_p.R181R	NM_021733.1	NP_068379.1	Q9UJT2	TSKS_HUMAN	testis-specific serine kinase substrate	381							protein binding			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(9)|prostate(3)|skin(3)	38		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		CCTGCAAGTCCCGCGCCGTCT	0.687000													4	32					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117044002	117044002	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:117044002C>T	ENST00000371876.1	-	4	2896	c.475G>A	c.(475-477)Gaa>Aaa	p.E159K	KLHL13_ENST00000371882.1_Missense_Mutation_p.E159K|KLHL13_ENST00000539496.1_Missense_Mutation_p.E213K|KLHL13_ENST00000540167.1_Missense_Mutation_p.E194K|KLHL13_ENST00000541812.1_Missense_Mutation_p.E194K|KLHL13_ENST00000469946.1_Missense_Mutation_p.E159K|KLHL13_ENST00000545703.1_Missense_Mutation_p.E168K|KLHL13_ENST00000262820.3_Missense_Mutation_p.E210K|KLHL13_ENST00000371878.1_Missense_Mutation_p.E159K			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	210	BTB.				cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						TTATCCACTTCGGTTAGATTG	0.388000													20	40					0	0	1	0	0
ACY3	91703	broad.mit.edu	37	11	67412787	67412787	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:67412787T>C	ENST00000255082.3	-	5	667	c.497A>G	c.(496-498)aAc>aGc	p.N166S	ACY3_ENST00000529256.1_Missense_Mutation_p.N45S	NM_080658.1	NP_542389.1	Q96HD9	ACY3_HUMAN	aspartoacylase (aminocyclase) 3	166					interspecies interaction between organisms	apical plasma membrane|cytoplasm	hydrolase activity, acting on ester bonds|metal ion binding			endometrium(1)|lung(5)|prostate(2)	8					L-Aspartic Acid(DB00128)	AGAGTCCAGGTTGTAGCTCTC	0.667000													8	14					0	0	1	0	0
OGDHL	55753	broad.mit.edu	37	10	50944443	50944443	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:50944443T>A	ENST00000374103.4	-	21	2799	c.2714A>T	c.(2713-2715)cAg>cTg	p.Q905L	OGDHL_ENST00000419399.1_Missense_Mutation_p.Q848L|OGDHL_ENST00000490844.1_5'UTR|OGDHL_ENST00000432695.1_Missense_Mutation_p.Q696L	NM_018245.2	NP_060715.2	Q9ULD0	OGDHL_HUMAN	oxoglutarate dehydrogenase-like	905					glycolysis	mitochondrial matrix	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	61						CTCCAGGTCCTGGCTGCTCCG	0.632000													34	15					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75097465	75097465	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:75097465C>T	ENST00000326665.5	-	7	969	c.751G>A	c.(751-753)Gaa>Aaa	p.E251K	C1orf173_ENST00000420661.2_Missense_Mutation_p.E54K	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	251										NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CTCCATGTTTCAGATCTATTT	0.368000													15	19					0	0	1	0	0
CCKAR	886	broad.mit.edu	37	4	26487354	26487354	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:26487354G>A	ENST00000295589.3	-	3	725	c.531C>T	c.(529-531)ccC>ccT	p.P177P		NM_000730.2	NP_000721.1	P32238	CCKAR_HUMAN	cholecystokinin A receptor	177					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			NS(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|pancreas(1)|skin(1)	29		Breast(46;0.0503)			Ceruletide(DB00403)	TGCTATAAATGGGGTACGGAG	0.473000													17	26					0	0	1	0	0
SF1	7536	broad.mit.edu	37	11	64533498	64533498	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:64533498G>A	ENST00000377390.3	-	13	2049	c.1712C>T	c.(1711-1713)cCc>cTc	p.P571L	SF1_ENST00000227503.9_Intron|SF1_ENST00000377387.1_Intron|SF1_ENST00000377394.3_Intron|SF1_ENST00000433274.2_Missense_Mutation_p.P545L|SF1_ENST00000422298.2_Intron|SF1_ENST00000334944.5_Missense_Mutation_p.P571L	NM_004630.3	NP_004621.2	Q15637	SF01_HUMAN	splicing factor 1	571	Pro-rich.				nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	31						CTGGACCCCGGGGGGCAGGGG	0.726000													11	15					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238280866	238280866	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:238280866C>T	ENST00000295550.4	-	9	4246	c.3794G>A	c.(3793-3795)gGc>gAc	p.G1265D	COL6A3_ENST00000472056.1_Missense_Mutation_p.G658D|COL6A3_ENST00000409809.1_Missense_Mutation_p.G1059D|COL6A3_ENST00000392003.2_Missense_Mutation_p.G858D|COL6A3_ENST00000392004.3_Missense_Mutation_p.G1059D|COL6A3_ENST00000353578.4_Missense_Mutation_p.G1059D|COL6A3_ENST00000347401.3_Missense_Mutation_p.G1064D|COL6A3_ENST00000346358.4_Missense_Mutation_p.G1065D	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	1265	Nonhelical region.|VWFA 7.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGTGTCAAAGCCCACGTCCAG	0.582000													13	5					0	0	1	0	0
SLC15A2	6565	broad.mit.edu	37	3	121643802	121643802	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:121643802C>T	ENST00000489711.1	+	13	1434	c.1046C>T	c.(1045-1047)cCc>cTc	p.P349L	SLC15A2_ENST00000295605.2_Missense_Mutation_p.P318L	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	349					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	GTTCTAAATCCCCTTCTGGTT	0.388000													25	67					0	0	1	0	0
CPXCR1	53336	broad.mit.edu	37	X	88009102	88009102	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:88009102C>T	ENST00000276127.4	+	3	946	c.687C>T	c.(685-687)ttC>ttT	p.F229F	CPXCR1_ENST00000373111.1_Silent_p.F229F	NM_033048.5	NP_149037.4	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	229						intracellular	zinc ion binding			NS(1)|cervix(1)|kidney(1)|large_intestine(11)|liver(1)|lung(20)|ovary(3)|upper_aerodigestive_tract(2)	40						AATGTAGATTCCGTGCTATTG	0.378000													5	16					0	0	1	0	0
CLTCL1	8218	broad.mit.edu	37	22	19230350	19230350	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:19230350G>A	ENST00000263200.10	-	4	701	c.629C>T	c.(628-630)gCc>gTc	p.A210V	CLTCL1_ENST00000427926.1_Missense_Mutation_p.A210V|CLTCL1_ENST00000353891.5_Missense_Mutation_p.A210V	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	210	Globular terminal domain.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					GGCAGGCTTGGCATTCCCCTC	0.507000			T	?	ALCL								25	26					0	0	1	0	0
PAPPA	5069	broad.mit.edu	37	9	119028186	119028186	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:119028186G>A	ENST00000328252.3	+	8	3152	c.2783G>A	c.(2782-2784)gGa>gAa	p.G928E	PAPPA_ENST00000534838.1_5'UTR	NM_002581.3	NP_002572.2	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A, pappalysin 1	928					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(9)|kidney(2)|large_intestine(23)|lung(33)|ovary(4)|pancreas(2)|prostate(5)|skin(7)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(1)	98						ACTATTTCAGGAACTGAAGAG	0.388000													19	3					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10705065	10705065	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:10705065G>A	ENST00000377022.3	-	18	4094	c.3777C>T	c.(3775-3777)ctC>ctT	p.L1259L	RP4-734G22.3_ENST00000606802.1_RNA	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	1259					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		TGTGCCAGGGGAGCTTGGTGG	0.602000													36	58					0	0	1	0	0
CX3CR1	1524	broad.mit.edu	37	3	39307312	39307312	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:39307312A>T	ENST00000541347.1	-	2	928	c.689T>A	c.(688-690)aTt>aAt	p.I230N	CX3CR1_ENST00000399220.2_Missense_Mutation_p.I230N|CX3CR1_ENST00000358309.3_Missense_Mutation_p.I262N|CX3CR1_ENST00000542107.1_Missense_Mutation_p.I230N	NM_001171171.1	NP_001164642.1	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	230					cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	24				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		GATCAGTTTAATGGCTTTGGC	0.443000													19	31					0	0	1	0	0
LOC653786	653786	broad.mit.edu	37	16	22588019	22588019	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:22588019C>T	ENST00000550753.1	+	0	2494					NR_003676.2																						CTGAGCACATCGTCCTGTGTT	0.572000													10	45					0	0	1	0	0
PCED1B	91523	broad.mit.edu	37	12	47629209	47629209	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:47629209G>A	ENST00000546455.1	+	4	1094	c.363G>A	c.(361-363)atG>atA	p.M121I	PCED1B_ENST00000432328.1_Missense_Mutation_p.M121I					PC-esterase domain containing 1B																		TGGTCATCATGAATTCCTGCC	0.572000													53	61					0	0	1	0	0
FOXR2	139628	broad.mit.edu	37	X	55650822	55650822	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:55650822C>T	ENST00000339140.3	+	1	990	c.678C>T	c.(676-678)ttC>ttT	p.F226F		NM_198451.3	NP_940853.1	Q6PJQ5	FOXR2_HUMAN	forkhead box R2	226					embryo development|organ development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			biliary_tract(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	19						GACAGCATTTCCCCTTTTTCT	0.507000													19	35					0	0	1	0	0
C17orf70	80233	broad.mit.edu	37	17	79512820	79512820	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:79512820G>A	ENST00000537152.1	-	6	2334	c.1809C>T	c.(1807-1809)atC>atT	p.I603I	C17orf70_ENST00000327787.8_Silent_p.I754I|C17orf70_ENST00000425898.2_Silent_p.I403I	NM_025161.5	NP_079437.5	Q0VG06	FP100_HUMAN	chromosome 17 open reading frame 70	754					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	19	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			CCACTCCCTGGATGGAAGATA	0.642000													9	5					0	0	1	0	0
LRRC14	9684	broad.mit.edu	37	8	145746708	145746708	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:145746708C>T	ENST00000292524.1	+	4	1474	c.1328C>T	c.(1327-1329)cCt>cTt	p.P443L	LRRC14_ENST00000529022.1_Missense_Mutation_p.P443L	NM_001272036.1|NM_014665.2	NP_001258965.1|NP_055480.1	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	443										endometrium(1)|lung(3)|prostate(1)	5	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TGGCCGCCGCCTGCCTCTGTC	0.627000													20	23					0	0	1	0	0
KCNJ9	3765	broad.mit.edu	37	1	160054455	160054455	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:160054455C>T	ENST00000368088.3	+	2	877	c.635C>T	c.(634-636)tCg>tTg	p.S212L		NM_004983.2	NP_004974.2	Q92806	IRK9_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 9	212					synaptic transmission	integral to membrane|plasma membrane	G-protein activated inward rectifier potassium channel activity|protein binding			biliary_tract(1)|endometrium(3)|large_intestine(3)|liver(1)|lung(5)|ovary(1)|skin(2)	16	all_cancers(52;5.86e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTCATCCGCTCGCGCCAGACG	0.682000													4	7					0	0	1	0	0
OR10C1	442194	broad.mit.edu	37	6	29408375	29408375	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:29408375G>A	ENST00000444197.2	+	1	1293	c.583G>A	c.(583-585)Gaa>Aaa	p.E195K	OR11A1_ENST00000377149.1_Intron	NM_013941.3	NP_039229.3	Q96KK4	O10C1_HUMAN	olfactory receptor, family 10, subfamily C, member 1 (gene/pseudogene)	195					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						CTCGCTTAATGAACTGCAGAT	0.562000													57	132					0	0	1	0	0
PHLDB3	653583	broad.mit.edu	37	19	43979573	43979573	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:43979573G>A	ENST00000292140.5	-	16	2272	c.1912C>T	c.(1912-1914)Cac>Tac	p.H638Y		NM_198850.3	NP_942147.3	Q6NSJ2	PHLB3_HUMAN	pleckstrin homology-like domain, family B, member 3	638										breast(1)|central_nervous_system(1)|lung(5)	7		Prostate(69;0.0153)				CAGGGGGCGTGGTTTTCGTCA	0.672000													16	15					0	0	1	0	0
CSH2	1443	broad.mit.edu	37	17	61949525	61949525	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:61949525C>T	ENST00000392886.2	-	5	766	c.615G>A	c.(613-615)atG>atA	p.M205I	CSH2_ENST00000336844.5_3'UTR|CSH2_ENST00000560142.1_Missense_Mutation_p.M148I|CSH2_ENST00000345366.7_Missense_Mutation_p.M110I	NM_020991.3	NP_066271.1	P01243	CSH_HUMAN	chorionic somatomammotropin hormone 2	205					female pregnancy|signal transduction	extracellular region	hormone activity|metal ion binding			endometrium(2)|large_intestine(1)|lung(3)	6						GGCACTGCACCATGCGCAGGA	0.587000													25	58					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22154175	22154175	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:22154175C>T	ENST00000397126.4	-	4	3809	c.3661G>A	c.(3661-3663)Gga>Aga	p.G1221R	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				GGTTTCTCTCCAGTATGAATT	0.383000													13	27					0	0	1	0	0
ZNF675	171392	broad.mit.edu	37	19	23836719	23836719	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:23836719G>A	ENST00000359788.4	-	4	1184	c.1016C>T	c.(1015-1017)cCc>cTc	p.P339L	ZNF675_ENST00000596211.1_Intron|ZNF675_ENST00000601935.1_Intron|ZNF675_ENST00000600313.1_Intron	NM_138330.2	NP_612203.2	Q8TD23	ZN675_HUMAN	zinc finger protein 675	339					bone resorption|cytokine-mediated signaling pathway|hemopoiesis|I-kappaB kinase/NF-kappaB cascade|negative regulation of JNK cascade|negative regulation of osteoclast differentiation|negative regulation of protein kinase activity|negative regulation of transcription, DNA-dependent|regulation of ossification|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	27		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				ACATTTGTAGGGTTTTTCTCC	0.388000													11	22					0	0	1	0	0
OR1N2	138882	broad.mit.edu	37	9	125316063	125316063	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr9:125316063C>T	ENST00000373688.2	+	1	673	c.615C>T	c.(613-615)gcC>gcT	p.A205A		NM_001004457.1	NP_001004457.1	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N, member 2	205					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(3)	26						TGAAGCTTGCCTGCTCAGATA	0.522000													21	21					0	0	1	0	0
COL22A1	169044	broad.mit.edu	37	8	139838948	139838948	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:139838948C>T	ENST00000303045.6	-	6	1368	c.922G>A	c.(922-924)Gaa>Aaa	p.E308K	COL22A1_ENST00000435777.1_Missense_Mutation_p.E308K	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	308	TSP N-terminal.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			TACCAGTCTTCCTTCCGAGAG	0.507000										HNSCC(7;0.00092)			19	27					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219874160	219874160	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr2:219874160C>T	ENST00000341552.5	-	28	4558	c.4475G>A	c.(4474-4476)gGg>gAg	p.G1492E	CCDC108_ENST00000453220.1_Missense_Mutation_p.G1492E|AC097468.4_ENST00000441450.1_RNA|CCDC108_ENST00000441968.1_Missense_Mutation_p.G1492E	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1492						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCCACCACCCCTATCATGGG	0.532000													17	6					0	0	1	0	0
RASGRP2	10235	broad.mit.edu	37	11	64508458	64508458	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:64508458C>T	ENST00000377494.1	-	4	1255	c.333G>A	c.(331-333)ggG>ggA	p.G111G	RASGRP2_ENST00000354024.3_Silent_p.G111G|RASGRP2_ENST00000394432.3_Silent_p.G111G|RASGRP2_ENST00000394430.1_Silent_p.G111G|RASGRP2_ENST00000377489.1_Silent_p.G111G|RASGRP2_ENST00000394428.1_3'UTR|RASGRP2_ENST00000377486.3_Silent_p.G111G|RASGRP2_ENST00000394429.1_3'UTR|RASGRP2_ENST00000377497.3_Silent_p.G111G|RASGRP2_ENST00000377487.1_Silent_p.G111G			Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2 (calcium and DAG-regulated)	111	N-terminal Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						GCCGTCGGTTCCCTTCTTGGT	0.577000											OREG0004006	type=REGULATORY REGION|Gene=RASGRP2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	19	19					0	0	1	0	0
TRBV5-7	28608	broad.mit.edu	37	7	142111678	142111678	+	RNA	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:142111678C>T	ENST00000390378.1	-	0	57																											ACTCCAGCGTCCACTGGGCCT	0.557000													18	53					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114179475	114179475	+	Missense_Mutation	SNP	C	C	T	rs144113099		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:114179475C>T	ENST00000357077.4	+	13	1347	c.1294C>T	c.(1294-1296)Ctc>Ttc	p.L432F	ANK2_ENST00000506722.1_Missense_Mutation_p.L411F|ANK2_ENST00000264366.6_Missense_Mutation_p.L432F|ANK2_ENST00000394537.3_Missense_Mutation_p.L432F	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	432					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GCAGTCTGGCCTCACACCAAT	0.488000													21	48					0	0	1	0	0
SLC14A1	6563	broad.mit.edu	37	18	43314342	43314342	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr18:43314342C>T	ENST00000321925.4	+	5	677	c.445C>T	c.(445-447)Cct>Tct	p.P149S	SLC14A1_ENST00000586142.1_Missense_Mutation_p.P149S|RP11-116O18.3_ENST00000586213.1_RNA|SLC14A1_ENST00000591943.1_3'UTR|SLC14A1_ENST00000502059.2_Missense_Mutation_p.P41S|SLC14A1_ENST00000436407.3_Missense_Mutation_p.P205S|SLC14A1_ENST00000415427.3_Missense_Mutation_p.P205S|SLC14A1_ENST00000535474.1_Missense_Mutation_p.P17S|SLC14A1_ENST00000589700.1_Missense_Mutation_p.P149S|SLC14A1_ENST00000402943.2_Missense_Mutation_p.P44S|RP11-116O18.3_ENST00000589510.1_RNA	NM_001128588.3|NM_001146036.2|NM_015865.6	NP_001122060.3|NP_001139508.2|NP_056949.4	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter), member 1	149						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	21						GCTGTTACTCCCTGTATGTGC	0.428000													16	33					0	0	1	0	0
GSX2	170825	broad.mit.edu	37	4	54968053	54968053	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:54968053C>T	ENST00000326902.2	+	2	1193	c.879C>T	c.(877-879)gcC>gcT	p.A293A	GSX2_ENST00000548609.1_3'UTR|GSX2_ENST00000503800.1_3'UTR|FIP1L1_ENST00000507166.1_Intron	NM_133267.2	NP_573574.1	Q9BZM3	GSX2_HUMAN	GS homeobox 2	293						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(2)|lung(2)	6	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			TGTCGCCGGCCTCAGCCAACG	0.662000													6	18					0	0	1	0	0
SERPIND1	3053	broad.mit.edu	37	22	21134401	21134401	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:21134401G>A	ENST00000215727.5	+	2	1084	c.801G>A	c.(799-801)atG>atA	p.M267I	PI4KA_ENST00000466162.1_Intron|SERPIND1_ENST00000406799.1_Missense_Mutation_p.M267I|PI4KA_ENST00000255882.6_Intron|PI4KA_ENST00000572273.1_Intron	NM_000185.3	NP_000176.2	P05546	HEP2_HUMAN	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	267					blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	ACCACATCATGAAGCTCACCA	0.433000													89	106					0	0	1	0	0
CRLF2	64109	broad.mit.edu	37	X	1317422	1317422	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:1317422G>A	ENST00000381567.3	-	5	642	c.643C>T	c.(643-645)Cgg>Tgg	p.R215W	CRLF2_ENST00000467626.1_Intron	NM_022148.2	NP_071431.2	Q9HC73	CRLF2_HUMAN	cytokine receptor-like factor 2	215						extracellular region|integral to membrane|plasma membrane	receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|lung(9)	20		all_cancers(21;9e-05)|all_epithelial(21;6.22e-06)|all_lung(23;0.000597)|Lung NSC(23;0.00901)|Lung SC(21;0.186)				GCATTACCCCGAATCTCGCCT	0.577000			"""Mis, T"""	"""P2RY8, IGH@"""	"""B-ALL, Downs associated ALL"""								35	69					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166935656	166935656	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:166935656G>A	ENST00000061240.2	+	8	1633	c.986G>A	c.(985-987)cGa>cAa	p.R329Q	TLL1_ENST00000513213.1_Missense_Mutation_p.R329Q|TLL1_ENST00000507499.1_Missense_Mutation_p.R329Q	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	329	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.R329Q(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		ATTGGTCAGCGAACCCGTCTA	0.458000													26	77					0	0	1	0	0
XKR3	150165	broad.mit.edu	37	22	17280787	17280787	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr22:17280787C>T	ENST00000331428.5	-	3	565	c.463G>A	c.(463-465)Gat>Aat	p.D155N		NM_175878.3	NP_787074.2	Q5GH77	XKR3_HUMAN	XK, Kell blood group complex subunit-related family, member 3	155						integral to membrane|plasma membrane				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(6)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				ATGAAATTATCCCGGATTGAG	0.398000													33	66					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103194136	103194136	+	Silent	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:103194136A>T	ENST00000428762.1	-	39	6099	c.5940T>A	c.(5938-5940)ctT>ctA	p.L1980L	RELN_ENST00000343529.5_Silent_p.L1980L|RELN_ENST00000424685.2_Silent_p.L1980L	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1980					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		ATGGACAATAAAGACCGATGT	0.363000													5	12					0	0	1	0	0
ZMAT1	84460	broad.mit.edu	37	X	101139700	101139700	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:101139700G>A	ENST00000458570.1	-	9	1516	c.186C>T	c.(184-186)gcC>gcT	p.A62A	ZMAT1_ENST00000372782.3_Silent_p.A233A|ZMAT1_ENST00000494068.1_5'UTR|ZMAT1_ENST00000540921.1_Silent_p.A233A			A7MD47	A7MD47_HUMAN	zinc finger, matrin-type 1	62						nucleus	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	22						CTAGTCCTCTGGCTTTCTGCA	0.408000													40	70					0	0	1	0	0
GLYATL2	219970	broad.mit.edu	37	11	58602310	58602310	+	Splice_Site	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:58602310C>T	ENST00000287275.1	-	6	867	c.476_splice	c.e6-1	p.K159_splice	GLYATL2_ENST00000532258.1_Splice_Site_p.K159_splice|GLYATL2_ENST00000533636.1_5'UTR	NM_145016.3	NP_659453.3	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	159						mitochondrion	glycine N-acyltransferase activity			breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	23		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	AGTTTCCTTCCCTGTGAAGAA	0.348000													4	14					0	0	1	0	0
SLC12A5	57468	broad.mit.edu	37	20	44665919	44665919	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr20:44665919C>T	ENST00000454036.1	+	6	652	c.576C>T	c.(574-576)tcC>tcT	p.S192S	SLC12A5_ENST00000243964.3_Silent_p.S169S|SLC12A5_ENST00000372315.1_Silent_p.S169S|SLC12A5_ENST00000539566.1_Silent_p.S169S	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	192					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	ACATGATTTCCAGGTCTCTGG	0.597000													16	36					0	0	1	0	0
PCDHGA3	56112	broad.mit.edu	37	5	140725539	140725539	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:140725539C>T	ENST00000253812.6	+	1	1939	c.1939C>T	c.(1939-1941)Cag>Tag	p.Q647*	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron	NM_018916.3|NM_032011.1	NP_061739.2|NP_114400.1														breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTGGCCGTCCAGGACCACGG	0.716000													45	71					0	0	1	0	0
RAB11FIP3	9727	broad.mit.edu	37	16	568977	568977	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:568977C>T	ENST00000262305.4	+	10	2063	c.1675C>T	c.(1675-1677)Cgg>Tgg	p.R559W	RAB11FIP3_ENST00000450428.1_Missense_Mutation_p.R263W|RAB11FIP3_ENST00000457159.1_Missense_Mutation_p.R604W	NM_014700.3	NP_055515.1	O75154	RFIP3_HUMAN	RAB11 family interacting protein 3 (class II)	559	ARF-binding domain (ABD).				cell cycle|cytokinesis|endocytic recycling|protein transport	centrosome|cleavage furrow|midbody|recycling endosome membrane	ADP-ribosylation factor binding|calcium ion binding|protein homodimerization activity|Rab GTPase binding			breast(1)|endometrium(2)|kidney(3)|lung(5)|upper_aerodigestive_tract(1)	12		Hepatocellular(16;0.0218)				CAGTGAACTCCGGTCCTGCAC	0.607000													32	81					0	0	1	0	0
THOC2	57187	broad.mit.edu	37	X	122747276	122747276	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:122747276C>T	ENST00000245838.8	-	36	4682	c.4651G>A	c.(4651-4653)Gat>Aat	p.D1551N	THOC2_ENST00000355725.4_Missense_Mutation_p.D1551N|THOC2_ENST00000464992.1_5'UTR|THOC2_ENST00000491737.1_Missense_Mutation_p.D1436N	NM_001081550.1	NP_001075019.1	Q8NI27	THOC2_HUMAN	THO complex 2	1551	Lys-rich.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			breast(2)|endometrium(13)|kidney(4)|large_intestine(11)|lung(26)|ovary(3)|skin(1)|upper_aerodigestive_tract(3)	63						GAGATTTTATCCATCTTCTCA	0.294000													21	24					0	0	1	0	0
CILP2	148113	broad.mit.edu	37	19	19656009	19656009	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr19:19656009G>A	ENST00000586018.1	+	8	2775	c.2673G>A	c.(2671-2673)cgG>cgA	p.R891R	CILP2_ENST00000291495.4_Silent_p.R885R			Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	885						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	32						GCAGCCTGCGGGAATGCCAGG	0.677000													24	33					0	0	1	0	0
TBC1D22B	55633	broad.mit.edu	37	6	37281614	37281614	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:37281614C>T	ENST00000373491.3	+	10	1258	c.1112C>T	c.(1111-1113)cCa>cTa	p.P371L		NM_017772.2	NP_060242.2	Q9NU19	TB22B_HUMAN	TBC1 domain family, member 22B	371	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)|endometrium(1)|large_intestine(2)|lung(10)|prostate(1)	15			OV - Ovarian serous cystadenocarcinoma(102;0.241)			TTTGCACAACCAGGAATCCAG	0.458000													23	97					0	0	1	0	0
OR52L1	338751	broad.mit.edu	37	11	6008061	6008061	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:6008061C>T	ENST00000332249.4	-	1	154	c.100G>A	c.(100-102)Ggg>Agg	p.G34R		NM_001005173.2	NP_001005173.2	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L, member 1	34					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(11)|pancreas(1)|skin(3)|soft_tissue(1)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CCTGGAATCCCTACCAGGAGA	0.463000													9	13					0	0	1	0	0
HGF	3082	broad.mit.edu	37	7	81381566	81381566	+	Silent	SNP	C	C	T	rs137853235		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:81381566C>T	ENST00000222390.5	-	5	721	c.495G>A	c.(493-495)tcG>tcA	p.S165S	HGF_ENST00000444829.2_Silent_p.S165S|HGF_ENST00000453411.1_Intron|HGF_ENST00000457544.2_Intron|HGF_ENST00000423064.2_Silent_p.S165S	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	165	Kringle 1.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						CCCGATAGCTCGAAGGCAAAA	0.403000													26	29					0	0	1	0	0
TTI2	80185	broad.mit.edu	37	8	33367358	33367358	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:33367358C>T	ENST00000431156.2	-	3	1358	c.740G>A	c.(739-741)aGg>aAg	p.R247K	TTI2_ENST00000520636.1_Missense_Mutation_p.R247K|TTI2_ENST00000360742.5_Missense_Mutation_p.R247K	NM_001102401.2	NP_001095871.1	Q6NXR4	CH041_HUMAN	TELO2 interacting protein 2	247							binding										GGGAAGTACCCTTTCCAGATG	0.473000													15	18					0	0	1	0	0
POLR3A	11128	broad.mit.edu	37	10	79742503	79742503	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr10:79742503G>A	ENST00000372371.3	-	27	3639	c.3502C>T	c.(3502-3504)Cat>Tat	p.H1168Y		NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	1168					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding			breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			GCCTCACCATGAACAGCCACA	0.532000													20	14					0	0	1	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1643028	1643028	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:1643028C>T	ENST00000399682.1	-	1	340	c.296G>A	c.(295-297)gGg>gAg	p.G99E		NM_001012709.1	NP_001012727.1	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	99	9 X 4 AA repeats of C-C-X-P.					keratin filament				NS(1)|endometrium(9)|kidney(2)|lung(2)|pancreas(1)|prostate(3)|skin(2)	20		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GCCACAGCCCCCCTTGGAACC	0.682000													26	89					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	10274178	10274178	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:10274178G>A	ENST00000396573.2	-	3	400	c.91C>T	c.(91-93)Ccc>Tcc	p.P31S	GRIN2A_ENST00000330684.3_Missense_Mutation_p.P31S|GRIN2A_ENST00000396575.2_Missense_Mutation_p.P31S|GRIN2A_ENST00000562109.1_Missense_Mutation_p.P31S|GRIN2A_ENST00000404927.2_Missense_Mutation_p.P31S	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	31					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGCGCGGGGGGACCCTTCTCC	0.692000													18	30					0	0	1	0	0
EDN1	1906	broad.mit.edu	37	6	12294322	12294322	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:12294322G>A	ENST00000379375.5	+	3	649	c.382G>A	c.(382-384)Gaa>Aaa	p.E128K		NM_001168319.1|NM_001955.4	NP_001161791.1|NP_001946.3	P05305	EDN1_HUMAN	endothelin 1	128					artery smooth muscle contraction|calcium-mediated signaling|leukocyte activation|negative regulation of blood coagulation|negative regulation of cellular protein metabolic process|negative regulation of nitric-oxide synthase biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|nitric oxide transport|peptide hormone secretion|phosphatidylinositol 3-kinase cascade|positive regulation of cardiac muscle hypertrophy|positive regulation of cell size|positive regulation of endothelial cell migration|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of JUN kinase activity|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of sarcomere organization|positive regulation of smooth muscle cell proliferation|prostaglandin biosynthetic process|protein kinase C deactivation|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	cytoplasm|extracellular space	cytokine activity|endothelin A receptor binding|endothelin B receptor binding|hormone activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	13	all_cancers(95;0.241)|Breast(50;0.0266)|Ovarian(93;0.12)	all_hematologic(90;0.117)				AGCAGGAAAAGAACTCAGGTG	0.428000													16	57					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60813480	60813480	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:60813480C>T	ENST00000544856.2	-	7	2124	c.1746G>A	c.(1744-1746)atG>atA	p.M582I	MARCH10_ENST00000311269.5_Missense_Mutation_p.M583I|MARCH10_ENST00000456609.2_Missense_Mutation_p.M583I|RP11-156L14.1_ENST00000579201.1_RNA|RP11-156L14.1_ENST00000582564.1_RNA|MARCH10_ENST00000583600.1_Missense_Mutation_p.M621I|RP11-156L14.1_ENST00000577270.1_RNA			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	583							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						CTTCTGAGTTCATTCTTGATG	0.433000													31	69					0	0	1	0	0
AMY2B	280	broad.mit.edu	37	1	104120425	104120425	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:104120425G>A	ENST00000361355.4	+	11	1920	c.1304G>A	c.(1303-1305)gGg>gAg	p.G435E	AMY2B_ENST00000491397.1_3'UTR	NM_020978.3	NP_066188.1	P19961	AMY2B_HUMAN	amylase, alpha 2B (pancreatic)	435					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding			breast(1)|endometrium(7)|kidney(4)|large_intestine(1)|lung(30)|prostate(1)|skin(1)|urinary_tract(1)	46		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		GTGGCTTTTGGGAGAGGAAAC	0.363000													58	107					0	0	1	0	0
OR4M1	441670	broad.mit.edu	37	14	20249337	20249337	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr14:20249337C>T	ENST00000315957.4	+	1	937	c.856C>T	c.(856-858)Ccc>Tcc	p.P286S		NM_001005500.1	NP_001005500.1	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M, member 1	286					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(32)|prostate(1)|skin(2)	42	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTTACTTAATCCCATTATTTA	0.368000													11	55					0	0	1	0	0
CDHR2	54825	broad.mit.edu	37	5	176002137	176002137	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:176002137G>T	ENST00000510636.1	+	8	822	c.548G>T	c.(547-549)gGc>gTc	p.G183V	CDHR2_ENST00000506348.1_Missense_Mutation_p.G183V|CDHR2_ENST00000261944.5_Missense_Mutation_p.G183V	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	183	Cadherin 2.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						CTGGCCAATGGCTCCATAGTC	0.622000													26	38					2.48779e-11	2.51912e-11	1	1	0
CSMD2	114784	broad.mit.edu	37	1	34082532	34082532	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:34082532C>T	ENST00000373381.4	-	39	6166	c.5990G>A	c.(5989-5991)tGg>tAg	p.W1997*	CSMD2_ENST00000373388.2_Nonsense_Mutation_p.W96*|CSMD2_ENST00000373380.1_Nonsense_Mutation_p.W870*|CSMD2_ENST00000373377.1_Nonsense_Mutation_p.W96*	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1957	CUB 12.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGGGTAGTTCCATCGCCGCAC	0.512000													23	30					0	0	1	0	0
LYSMD2	256586	broad.mit.edu	37	15	52016990	52016990	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr15:52016990C>T	ENST00000267838.3	-	2	1116	c.602G>A	c.(601-603)aGc>aAc	p.S201N	LYSMD2_ENST00000454181.2_Missense_Mutation_p.S110N|LYSMD2_ENST00000560491.1_Missense_Mutation_p.S110N|LYSMD2_ENST00000558126.1_Missense_Mutation_p.S94N	NM_153374.2	NP_699205.1	Q8IV50	LYSM2_HUMAN	LysM, putative peptidoglycan-binding, domain containing 2	201					cell wall macromolecule catabolic process					lung(2)|upper_aerodigestive_tract(1)	3				all cancers(107;0.00258)		TTCTTACCTGCTCTCTTCTTT	0.413000													18	24					0	0	1	0	0
ALOX15B	247	broad.mit.edu	37	17	7942602	7942602	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:7942602G>A	ENST00000380183.4	+	1	268	c.129G>A	c.(127-129)aaG>aaA	p.K43K	ALOX15B_ENST00000572022.1_Silent_p.K43K|ALOX15B_ENST00000573359.1_Silent_p.K43K|ALOX15B_ENST00000380173.2_Silent_p.K43K	NM_001141.2	NP_001132.2	O15296	LX15B_HUMAN	arachidonate 15-lipoxygenase, type B	43	PLAT.				induction of apoptosis|leukotriene biosynthetic process|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of growth|prostate gland development|regulation of epithelial cell differentiation	cytoplasm	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|prostate(2)|skin(2)|stomach(4)|upper_aerodigestive_tract(1)	24						ATCTCGGCAAGGAGTTCACTG	0.652000													27	14					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48696570	48696570	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:48696570G>A	ENST00000544264.1	-	1	3778	c.3498C>T	c.(3496-3498)agC>agT	p.S1166S	CELSR3_ENST00000164024.4_Silent_p.S1166S			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	1166	Cadherin 8.				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TGAGCACAGGGCTGTTGTCAT	0.542000													16	40					0	0	1	0	0
FGF5	2250	broad.mit.edu	37	4	81207518	81207518	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr4:81207518C>T	ENST00000312465.7	+	3	725	c.499C>T	c.(499-501)Caa>Taa	p.Q167*	FGF5_ENST00000456523.3_3'UTR|FGF5_ENST00000503413.1_3'UTR	NM_004464.3	NP_004455.2	P12034	FGF5_HUMAN	fibroblast growth factor 5	167					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	22						GGAGCGTTTTCAAGAAAATAG	0.403000													37	60					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12626229	12626229	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:12626229G>A	ENST00000425538.1	+	5	519	c.319G>A	c.(319-321)Gat>Aat	p.D107N	MYOCD_ENST00000343344.4_Missense_Mutation_p.D107N|MYOCD_ENST00000395988.1_Missense_Mutation_p.D11N	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	107					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		ACTCGCCGATGATCTCAATGA	0.458000													52	23					0	0	1	0	0
MRPL37	51253	broad.mit.edu	37	1	54665994	54665994	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr1:54665994G>A	ENST00000605337.1	+	1	126	c.78G>A	c.(76-78)ccG>ccA	p.P26P	MRPL37_ENST00000336230.6_5'UTR|MRPL37_ENST00000360840.5_Silent_p.P26P|MRPL37_ENST00000487096.1_Intron			Q9BZE1	RM37_HUMAN	mitochondrial ribosomal protein L37	26					translation	mitochondrial ribosome	structural constituent of ribosome			NS(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(2)|lung(4)|skin(2)	19						TCGGGGCCCCGAGACGCGGGG	0.687000													32	45					0	0	1	0	0
POU1F1	5449	broad.mit.edu	37	3	87311239	87311239	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr3:87311239C>T	ENST00000350375.2	-	4	710	c.586G>A	c.(586-588)Gaa>Aaa	p.E196K	POU1F1_ENST00000344265.3_Missense_Mutation_p.E222K|POU1F1_ENST00000560656.1_Intron	NM_000306.2	NP_000297.1	P28069	PIT1_HUMAN	POU class 1 homeobox 1	196	POU-specific.				negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|large_intestine(5)|liver(1)|lung(7)|prostate(2)|skin(2)	18	all_cancers(8;0.104)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00229)|Lung(72;0.00677)		TGCTCAGCTTCCTCCAGCCAT	0.378000													25	30					0	0	1	0	0
AKAP9	10142	broad.mit.edu	37	7	91699371	91699371	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:91699371G>A	ENST00000359028.2	+	28	6619	c.6394G>A	c.(6394-6396)Gaa>Aaa	p.E2132K	AKAP9_ENST00000356239.3_Missense_Mutation_p.E2120K|AKAP9_ENST00000358100.2_Missense_Mutation_p.E2132K			Q99996	AKAP9_HUMAN	A kinase (PRKA) anchor protein 9	2132	Glu-rich.				G2/M transition of mitotic cell cycle|signal transduction|synaptic transmission|transport	centrosome|cytosol|Golgi apparatus	receptor binding			NS(1)|autonomic_ganglia(2)|breast(14)|central_nervous_system(3)|cervix(1)|endometrium(13)|kidney(12)|large_intestine(35)|lung(49)|ovary(8)|prostate(6)|skin(8)|stomach(1)|urinary_tract(2)	155	all_cancers(62;2.46e-09)|all_epithelial(64;4.42e-08)|Breast(17;0.00206)|all_lung(186;0.185)|all_hematologic(106;0.215)|Lung NSC(181;0.249)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			TCATCTGAAAGAAAAAACAGA	0.328000			T	BRAF	papillary thyroid								28	48					0	0	1	0	0
ZNF668	79759	broad.mit.edu	37	16	31073159	31073159	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:31073159A>T	ENST00000538906.1	-	3	1874	c.1090T>A	c.(1090-1092)Ttc>Atc	p.F364I	ZNF668_ENST00000535577.1_Missense_Mutation_p.F364I|ZNF668_ENST00000426488.2_Missense_Mutation_p.F387I|ZNF668_ENST00000417110.2_Missense_Mutation_p.K116M|ZNF668_ENST00000394983.2_Missense_Mutation_p.F364I|ZNF668_ENST00000539836.3_Missense_Mutation_p.F387I|ZNF668_ENST00000300849.4_Missense_Mutation_p.F364I	NM_001172668.1	NP_001166139.1	Q96K58	ZN668_HUMAN	zinc finger protein 668	364					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						TCACAGCGGAAGGGCCGCTGG	0.672000													49	70					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92257970	92257970	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:92257970C>T	ENST00000298047.6	+	2	3480	c.3463C>T	c.(3463-3465)Cct>Tct	p.P1155S	FAT3_ENST00000409404.2_Missense_Mutation_p.P1155S|FAT3_ENST00000541502.1_Missense_Mutation_p.P1155S|FAT3_ENST00000525166.1_Missense_Mutation_p.P1005S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1155	Cadherin 11.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TATATATTATCCTGTTGTCAT	0.443000										TCGA Ovarian(4;0.039)			9	14					0	0	1	0	0
RFX6	222546	broad.mit.edu	37	6	117216371	117216371	+	Splice_Site	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:117216371G>A	ENST00000332958.2	+	6	688		c.e6+1		RFX6_ENST00000471966.1_Splice_Site	NM_173560.3	NP_775831.2	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6						glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						AAAGAATGAGGTAAGAATTAT	0.284000													11	4					0	0	1	0	0
OR9Q2	219957	broad.mit.edu	37	11	57958001	57958001	+	Silent	SNP	C	C	T			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:57958001C>T	ENST00000311591.3	+	1	96	c.39C>T	c.(37-39)ttC>ttT	p.F13F		NM_001005283.2	NP_001005283.1	Q8NGE9	OR9Q2_HUMAN	olfactory receptor, family 9, subfamily Q, member 2	13					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|large_intestine(3)|lung(24)|ovary(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	41		Breast(21;0.0589)				CGGAGTTCTTCCTTACTGCAT	0.478000													17	20					0	0	1	0	0
RAG2	5897	broad.mit.edu	37	11	36614459	36614459	+	Silent	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:36614459G>A	ENST00000311485.3	-	2	1421	c.1260C>T	c.(1258-1260)tgC>tgT	p.C420C		NM_000536.3|NM_001243785.1|NM_001243786.1	NP_000527.2|NP_001230714.1|NP_001230715.1	P55895	RAG2_HUMAN	recombination activating gene 2	420					chromatin modification|pre-B cell allelic exclusion|somatic diversification of immunoglobulins|T cell differentiation in thymus|V(D)J recombination	nucleus	chromatin binding|DNA binding|endonuclease activity|methylated histone residue binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	32	all_lung(20;0.226)	all_hematologic(20;0.00756)				CACAAGTAGGGCAGCATGTAA	0.443000									Familial Hemophagocytic Lymphohistiocytosis				28	43					0	0	1	0	0
EFCAB4B	84766	broad.mit.edu	37	12	3788238	3788238	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:3788238G>A	ENST00000440314.2	-	6	840	c.367C>T	c.(367-369)Cca>Tca	p.P123S	EFCAB4B_ENST00000252322.1_Missense_Mutation_p.P123S|EFCAB4B_ENST00000444507.1_Missense_Mutation_p.P123S	NM_001144958.1	NP_001138430.1	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B	123					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			breast(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|pancreas(2)|prostate(1)|upper_aerodigestive_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			TCCTGACTTGGGTTATTCTGG	0.547000													24	17					0	0	1	0	0
C5orf28	64417	broad.mit.edu	37	5	43446390	43446390	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr5:43446390G>C	ENST00000500337.2	-	5	913	c.582C>G	c.(580-582)ttC>ttG	p.F194L	C5orf28_ENST00000512085.1_Missense_Mutation_p.F194L|C5orf28_ENST00000397080.3_Missense_Mutation_p.F194L|C5orf28_ENST00000510130.1_Missense_Mutation_p.F92L|C5orf28_ENST00000511525.1_Intron|C5orf28_ENST00000537319.1_Missense_Mutation_p.F63L			Q0VDI3	CE028_HUMAN	chromosome 5 open reading frame 28	194						integral to membrane				breast(1)|kidney(1)|large_intestine(2)|lung(5)	9	Lung NSC(6;2.07e-05)					AATACATAACGAATGAACAGA	0.388000													17	12					0	0	1	0	0
HLA-DRB6	3128	broad.mit.edu	37	6	32522756	32522756	+	RNA	DEL	A	A	-			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr6:32522756delA	ENST00000411500.1	-	0	458					NR_001298.1																						GGACTAGGAGAAAAAAAGGTA	0.517													5	2	---	---	---	---					
INTS4P2	644619	broad.mit.edu	37	7	65150817	65150817	+	RNA	DEL	C	C	-			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr7:65150817delC	ENST00000430126.2	+	0	757																											TCATCCCTCACCCCCCCCCCC	0.468													3	5	---	---	---	---					
TRIM55	84675	broad.mit.edu	37	8	67039376	67039376	+	Translation_Start_Site	DEL	A	A	-			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr8:67039376delA	ENST00000315962.4	+	0	246				TRIM55_ENST00000353317.5_De_novo_Start_OutOfFrame|TRIM55_ENST00000276573.7_De_novo_Start_OutOfFrame|TRIM55_ENST00000350034.4_De_novo_Start_OutOfFrame	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55							cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			GGCCTGAAACAATGTCCTCCA	0.537													2	4	---	---	---	---					
CCND1	595	broad.mit.edu	37	11	69465987	69465988	+	In_Frame_Ins	INS	-	-	GAG	rs3830296		TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr11:69465987_69465988insGAG	ENST00000227507.2	+	5	1052_1053	c.825_826insGAG	c.(823-828)gaagga>gaGAGagga	p.275_276EG>ERG		NM_053056.2	NP_444284.1	P24385	CCND1_HUMAN	cyclin D1	275	Poly-Glu.				cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|mitotic cell cycle G1/S transition DNA damage checkpoint|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation|response to drug|response to UV-A|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane|nucleoplasm	protein kinase binding			NS(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|ovary(1)|urinary_tract(1)	23	all_cancers(3;2.01e-114)|all_epithelial(3;3.59e-122)|Breast(3;5.4e-34)|all_lung(4;1.99e-21)|Lung NSC(4;4.65e-21)|Hepatocellular(3;8.22e-16)|Melanoma(5;1.89e-05)|Ovarian(3;0.0348)		Epithelial(3;7.2e-57)|all cancers(3;7.75e-51)|BRCA - Breast invasive adenocarcinoma(2;4.9e-48)|Lung(3;1.13e-16)|LUSC - Lung squamous cell carcinoma(11;3.74e-15)|STAD - Stomach adenocarcinoma(18;0.0278)|LUAD - Lung adenocarcinoma(13;0.0537)		Arsenic trioxide(DB01169)	aggaggaggaagaggaggagga	0.703			T	"""IGH@, FSTL3"""	"""CLL, B-ALL, breast"""					Multiple Myeloma(6;0.086)			14	21	---	---	---	---					
KRT83	3889	broad.mit.edu	37	12	52714787	52714789	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr12:52714787_52714789delCTC	ENST00000293670.3	-	1	393_395	c.331_333delGAG	c.(331-333)del	p.E111del		NM_002282.3	NP_002273.3	P78385	KRT83_HUMAN	keratin 83	111	Head.				epidermis development	keratin filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(4)|stomach(7)|upper_aerodigestive_tract(1)	32	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TCTGCTCCTTCTCCTCCTGCTTC	0.591													51	80	---	---	---	---					
IRS2	8660	broad.mit.edu	37	13	110437402	110437402	+	Frame_Shift_Del	DEL	G	G	-			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr13:110437402delG	ENST00000375856.3	-	1	1513	c.999delC	c.(997-999)ccfs	p.P333fs		NM_003749.2	NP_003740.2	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	333					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	19	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			CCGTCTGGCTGGGGGGCAGGT	0.766													2	4	---	---	---	---					
PAGR1	79447	broad.mit.edu	37	16	29827970	29827971	+	Frame_Shift_Ins	INS	-	-	CGGC			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr16:29827970_29827971insCGGC	ENST00000320330.6	+	1	686_687	c.124_125insCGGC	c.(124-126)ggcfs	p.G42fs	AC009133.20_ENST00000569039.1_RNA	NM_024516.3	NP_078792.1			PAXIP1 associated glutamate-rich protein 1																		CCCCTCTGCCTCGGCCGGTAAG	0.708											OREG0023722	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	13	---	---	---	---					
LUC7L3	51747	broad.mit.edu	37	17	48822077	48822078	+	Frame_Shift_Ins	INS	-	-	A			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chr17:48822077_48822078insA	ENST00000505658.1	+	7	785_786	c.596_597insA	c.(595-597)tatfs	p.Y199fs	LUC7L3_ENST00000393227.2_Frame_Shift_Ins_p.Y199fs|LUC7L3_ENST00000544170.1_Frame_Shift_Ins_p.Y123fs|LUC7L3_ENST00000240304.1_Frame_Shift_Ins_p.Y199fs			O95232	LC7L3_HUMAN	LUC7-like 3 (S. cerevisiae)	199					apoptosis|mRNA processing|response to stress|RNA splicing	focal adhesion|nuclear speck	DNA binding|mRNA binding|protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)	12						GGAGCCTTTTTAATAGTAGGAG	0.351													18	34	---	---	---	---					
FAM155B	27112	broad.mit.edu	37	X	68725949	68725949	+	Frame_Shift_Del	DEL	A	A	-			TCGA-D3-A51T-06A-11D-A25O-08	TCGA-D3-A51T-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	CEA01CB3-C933-4ABC-82E8-E051238383ED	9BE2BD0D-64C0-484A-9E16-9DD80FD06420	g.chrX:68725949delA	ENST00000252338.4	+	1	866	c.824delA	c.(823-825)gafs	p.E276fs		NM_015686.2	NP_056501.2	O75949	F155B_HUMAN	family with sequence similarity 155, member B	276						integral to membrane				autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)	16						TTACAGGCGGAAGAGTACTCA	0.592													3	6	---	---	---	---					
