Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CNTN6	27255	broad.mit.edu	37	3	1424997	1424997	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:1424997G>A	ENST00000446702.2	+	19	3049	c.2422G>A	c.(2422-2424)Gga>Aga	p.G808R	CNTN6_ENST00000350110.2_Missense_Mutation_p.G808R|CNTN6_ENST00000539053.1_Missense_Mutation_p.G736R			Q9UQ52	CNTN6_HUMAN	contactin 6	808	Fibronectin type-III 3.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		GGCCCCAAGGGGAACTTCTCT	0.433000													85	120					0	0	1	0	0
CNOT4	4850	broad.mit.edu	37	7	135098321	135098321	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:135098321C>T	ENST00000428680.2	-	6	882	c.603G>A	c.(601-603)aaG>aaA	p.K201K	CNOT4_ENST00000423368.2_Silent_p.K201K|CNOT4_ENST00000541284.1_Silent_p.K201K|CNOT4_ENST00000414802.1_Silent_p.K201K|CNOT4_ENST00000315544.5_Silent_p.K201K|CNOT4_ENST00000356162.4_Silent_p.K201K|CNOT4_ENST00000361528.4_Silent_p.K201K|CNOT4_ENST00000451834.1_Silent_p.K201K	NM_001008225.2	NP_001008226.1	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	201					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	22						ACTGCATATTCTTTAAGAAGT	0.428000													16	34					0	0	1	0	0
LAMB2	3913	broad.mit.edu	37	3	49160884	49160884	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:49160884G>A	ENST00000418109.1	-	26	4142	c.3978C>T	c.(3976-3978)ttC>ttT	p.F1326F	LAMB2_ENST00000305544.4_Silent_p.F1326F	NM_002292.3	NP_002283.3	P55268	LAMB2_HUMAN	laminin, beta 2 (laminin S)	1326	Domain II.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			NS(1)|breast(1)|endometrium(15)|kidney(3)|large_intestine(6)|lung(21)|ovary(4)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	61				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ACTCACCCAGGAAGTTTGAAT	0.522000													23	46					0	0	1	0	0
MAMDC2	256691	broad.mit.edu	37	9	72758635	72758635	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:72758635A>C	ENST00000377182.4	+	9	1921	c.1304A>C	c.(1303-1305)gAg>gCg	p.E435A	MAMDC2-AS1_ENST00000591368.1_RNA	NM_153267.4	NP_694999.3	Q7Z304	MAMC2_HUMAN	MAM domain containing 2	435	MAM 3.					endoplasmic reticulum|membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|pancreas(1)|upper_aerodigestive_tract(1)	14						ATCTTTGAAGAGAACCATGTG	0.443000													44	25					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179432597	179432597	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179432597G>A	ENST00000589042.1	-	326	78486	c.78262C>T	c.(78262-78264)Ccc>Tcc	p.P26088S	TTN_ENST00000342992.6_Missense_Mutation_p.P23520S|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P24447S|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P17023S|TTN_ENST00000342175.6_Missense_Mutation_p.P17215S|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P17148S|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24447	Ig-like 126.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.P17148S(1)|p.P17023S(1)|p.P17215S(1)|p.P23518S(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGTCACAGGGATCTCTGGCT	0.398000													52	125					0	0	1	0	0
SRRM4	84530	broad.mit.edu	37	12	119592120	119592120	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:119592120G>A	ENST00000267260.4	+	12	1852	c.1464G>A	c.(1462-1464)cgG>cgA	p.R488R		NM_194286.3	NP_919262.2	A7MD48	SRRM4_HUMAN	serine/arginine repetitive matrix 4	488	Arg-rich.|Ser-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)|upper_aerodigestive_tract(1)	24						GGAGACGTCGGTCCTACTCGC	0.672000													4	13					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24488226	24488226	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:24488226C>T	ENST00000264463.4	-	12	2420	c.1913G>A	c.(1912-1914)cGa>cAa	p.R638Q	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	638					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.R638L(1)|p.R638Q(1)		NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		CTCTTTTTTTCGCTGTCTTTT	0.398000										HNSCC(23;0.051)			15	50					0	0	1	0	0
OTOL1	131149	broad.mit.edu	37	3	161214933	161214933	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:161214933G>A	ENST00000327928.4	+	1	338	c.338G>A	c.(337-339)gGa>gAa	p.G113E		NM_001080440.1	NP_001073909.1	A6NHN0	OTOL1_HUMAN	otolin 1	113						collagen				central_nervous_system(2)|kidney(2)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)	27						GGGCAGAAAGGAGAACCTGGA	0.443000													37	49					0	0	1	0	0
KLHL5	51088	broad.mit.edu	37	4	39088189	39088189	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:39088189G>A	ENST00000261425.3	+	6	1107	c.955G>A	c.(955-957)Gaa>Aaa	p.E319K	KLHL5_ENST00000261426.5_Missense_Mutation_p.E304K|KLHL5_ENST00000381930.3_Missense_Mutation_p.E365K|KLHL5_ENST00000508137.2_Missense_Mutation_p.E178K|KLHL5_ENST00000359687.2_Missense_Mutation_p.E365K|KLHL5_ENST00000504108.1_Missense_Mutation_p.E365K	NM_001007075.2	NP_001007076.1	Q96PQ7	KLHL5_HUMAN	kelch-like family member 5	365						cytoplasm|cytoskeleton	actin binding			endometrium(3)|kidney(1)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	29						ACCAGCCAGCGAAATTGCAAA	0.393000													56	29					0	0	1	0	0
LIPH	200879	broad.mit.edu	37	3	185229381	185229381	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:185229381G>A	ENST00000296252.4	-	9	1340	c.1199C>T	c.(1198-1200)tCt>tTt	p.S400F	LIPH_ENST00000424591.2_Missense_Mutation_p.S366F	NM_139248.2	NP_640341.1	Q8WWY8	LIPH_HUMAN	lipase, member H	400					lipid catabolic process	extracellular space|plasma membrane	heparin binding|phospholipase activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(2)	20	all_cancers(143;8.87e-11)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			GCCTATTAGAGATCCTGTAGA	0.453000													36	55					0	0	1	0	0
MYL1	4632	broad.mit.edu	37	2	211163274	211163274	+	Silent	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:211163274T>A	ENST00000352451.3	-	3	321	c.174A>T	c.(172-174)gcA>gcT	p.A58A	MYL1_ENST00000496436.1_5'UTR|MYL1_ENST00000341685.4_Silent_p.A14A	NM_079420.2	NP_524144.1	P05976	MYL1_HUMAN	myosin, light chain 1, alkali; skeletal, fast	58	EF-hand 1.				muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)	16				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		ACAGGAGAAATGCCTCCTTGA	0.418000													9	36					0	0	1	0	0
OR10G7	390265	broad.mit.edu	37	11	123908929	123908929	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:123908929C>T	ENST00000330487.5	-	1	788	c.780G>A	c.(778-780)agG>agA	p.R260R		NM_001004463.1	NP_001004463.1	Q8NGN6	O10G7_HUMAN	olfactory receptor, family 10, subfamily G, member 7	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(6)|lung(20)|ovary(2)|prostate(2)|stomach(3)|urinary_tract(1)	47		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		TGGAGCCTGGCCTCAGGTAAA	0.557000													32	54					0	0	1	0	0
NETO2	81831	broad.mit.edu	37	16	47143407	47143407	+	Silent	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:47143407A>G	ENST00000562435.1	-	7	1254	c.870T>C	c.(868-870)acT>acC	p.T290T	NETO2_ENST00000303155.5_Silent_p.T283T	NM_018092.4	NP_060562.3	Q8NC67	NETO2_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 2	290	CUB 2.					integral to membrane	receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	29		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				CCACAAAGGAAGTAAAGAGCA	0.363000										HNSCC(25;0.065)			24	40					0	0	1	0	0
CDH4	1002	broad.mit.edu	37	20	60485487	60485487	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:60485487G>A	ENST00000360469.5	+	9	1286	c.1198G>A	c.(1198-1200)Gag>Aag	p.E400K	CDH4_ENST00000543233.1_Missense_Mutation_p.E326K	NM_001794.3	NP_001785.2	P55283	CADH4_HUMAN	cadherin 4, type 1, R-cadherin (retinal)	400	Cadherin 3.				adherens junction organization|cell junction assembly		calcium ion binding			NS(2)|breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(2)|lung(25)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			GTTTGCAGGGGAGGTCCCCGA	0.512000													14	29					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363199	22363199	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:22363199C>T	ENST00000397121.2	-	3	1637	c.1320G>A	c.(1318-1320)aaG>aaA	p.K440K		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	440					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.K440N(1)		NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				CATGAATTCTCTTGTGTTCAG	0.438000													38	49					0	0	1	0	0
MAP4K1	11184	broad.mit.edu	37	19	39086130	39086130	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:39086130C>T	ENST00000591517.1	-	29	2363	c.2335G>A	c.(2335-2337)Gat>Aat	p.D779N	MAP4K1_ENST00000396857.2_Missense_Mutation_p.D779N|MAP4K1_ENST00000589130.1_Missense_Mutation_p.D775N|MAP4K1_ENST00000586296.1_Missense_Mutation_p.D353N	NM_007181.4	NP_009112.1	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase kinase 1	779	CNH.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(3)|lung(24)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	44	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CTTACCTGATCCGAGCCTAGA	0.562000													15	31					0	0	1	0	0
TRIB1	10221	broad.mit.edu	37	8	126448372	126448372	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:126448372T>C	ENST00000311922.3	+	3	1360	c.778T>C	c.(778-780)Tac>Cac	p.Y260H	TRIB1_ENST00000520847.1_Missense_Mutation_p.Y94H|TRIB1_ENST00000519576.1_Missense_Mutation_p.Y29H	NM_025195.2	NP_079471.1	Q96RU8	TRIB1_HUMAN	tribbles pseudokinase 1	260	Protein kinase.				JNK cascade|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of smooth muscle cell migration|negative regulation of smooth muscle cell proliferation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity|response to lipopolysaccharide	cytoplasm|nucleus	ATP binding|mitogen-activated protein kinase kinase binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			NS(1)|large_intestine(2)|lung(2)|prostate(2)|urinary_tract(1)	8	all_hematologic(1;4.97e-05)|Ovarian(258;0.00167)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			CACTGGGACCTACTCCGGAAA	0.547000													10	27					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22383012	22383012	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:22383012T>G	ENST00000328795.4	+	1	631	c.540T>G	c.(538-540)gaT>gaG	p.D180E	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TCTTCTGTGATGTCCGACAGG	0.532000													20	48					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117301690	117301690	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:117301690C>T	ENST00000321322.6	-	32	5615	c.5614G>A	c.(5614-5616)Gcc>Acc	p.A1872T	DSCAML1_ENST00000527706.1_Missense_Mutation_p.A1602T	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1812					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TAGGCCCGGGCCAGCTCCTCG	0.572000													61	109					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32029314	32029314	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:32029314C>T	ENST00000375244.3	-	21	7553	c.7352G>A	c.(7351-7353)cGg>cAg	p.R2451Q	TNXB_ENST00000375247.2_Missense_Mutation_p.R2451Q			P22105	TENX_HUMAN	tenascin XB	2511					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CACCTGGGGCCGCCCGTCCCT	0.662000													31	63					0	0	1	0	0
PLA2G7	7941	broad.mit.edu	37	6	46675802	46675802	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:46675802G>A	ENST00000274793.7	-	10	1162	c.966C>T	c.(964-966)ttC>ttT	p.F322F	PLA2G7_ENST00000537365.1_Silent_p.F322F	NM_005084.3	NP_005075.3	Q13093	PAFA_HUMAN	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	322					inflammatory response|lipid catabolic process	extracellular space	1-alkyl-2-acetylglycerophosphocholine esterase activity|phospholipid binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(5)|skin(1)|soft_tissue(1)	14			Lung(136;0.192)			CAGGATATTGGAAATATTCAG	0.343000													10	32					0	0	1	0	0
CFL1	1072	broad.mit.edu	37	11	65623182	65623182	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:65623182G>A	ENST00000525451.2	-	4	1046	c.331C>T	c.(331-333)Ctt>Ttt	p.L111F	CFL1_ENST00000524553.1_Missense_Mutation_p.L94F|CFL1_ENST00000527344.1_Missense_Mutation_p.L94F|CFL1_ENST00000531407.1_Missense_Mutation_p.L94F|CFL1_ENST00000531413.1_Missense_Mutation_p.L94F|CFL1_ENST00000308162.5_Missense_Mutation_p.L111F|CFL1_ENST00000534769.1_Missense_Mutation_p.L149F			P23528	COF1_HUMAN	cofilin 1 (non-muscle)	111	ADF-H.				actin cytoskeleton organization|anti-apoptosis|axon guidance|platelet activation|platelet degranulation|response to virus|Rho protein signal transduction	cytoplasm|cytoskeleton|nuclear matrix	actin binding			breast(1)|kidney(1)|large_intestine(2)|lung(2)	6				READ - Rectum adenocarcinoma(159;0.169)		TTGCTCTTAAGGGGCGCAGAC	0.562000													17	19					0	0	1	0	0
DLGAP4	22839	broad.mit.edu	37	20	35060493	35060493	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:35060493C>T	ENST00000373913.3	+	3	853	c.373C>T	c.(373-375)Ccc>Tcc	p.P125S	DLGAP4_ENST00000373907.2_Missense_Mutation_p.P125S|DLGAP4_ENST00000401952.2_Missense_Mutation_p.P125S|DLGAP4_ENST00000339266.5_Missense_Mutation_p.P125S			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	125					cell-cell signaling	membrane	protein binding	p.P125S(2)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CCTCCAATTTCCCCGTGGCGA	0.632000													49	97					0	0	1	0	0
DHX33	56919	broad.mit.edu	37	17	5364307	5364307	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:5364307C>T	ENST00000225296.3	-	4	1001	c.801G>A	c.(799-801)caG>caA	p.Q267Q	DHX33_ENST00000433302.3_Intron	NM_001199699.1|NM_020162.3	NP_001186628.1|NP_064547.2	Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	267						nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GGTAATCATTCTGAGGCTGTT	0.522000													72	22					0	0	1	0	0
BTNL2	56244	broad.mit.edu	37	6	32372983	32372983	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:32372983G>A	ENST00000454136.3	-	2	164	c.160C>T	c.(160-162)Ccc>Tcc	p.P54S	BTNL2_ENST00000414363.1_Intron|BTNL2_ENST00000429232.2_Missense_Mutation_p.P54S|BTNL2_ENST00000544175.1_5'UTR|BTNL2_ENST00000374993.1_Missense_Mutation_p.P54S|BTNL2_ENST00000374995.3_Missense_Mutation_p.P54S|BTNL2_ENST00000540315.1_Intron			Q9UIR0	BTNL2_HUMAN	butyrophilin-like 2 (MHC class II associated)	54	Ig-like V-type 1.					integral to membrane				central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|prostate(1)|urinary_tract(1)	19						GTCCTCTTGGGGAGTAGCTGG	0.532000													44	91					0	0	1	0	0
H1FNT	341567	broad.mit.edu	37	12	48723366	48723366	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:48723366G>A	ENST00000335017.1	+	1	604	c.292G>A	c.(292-294)Gaa>Aaa	p.E98K		NM_181788.1	NP_861453.1	Q75WM6	H1FNT_HUMAN	H1 histone family, member N, testis-specific	98					chromosome condensation|multicellular organismal development|sperm chromatin condensation|spermatid nucleus elongation	nuclear chromatin	ATP binding|DNA binding			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	13						CGGCCGCCACGAAGCGCCCAG	0.662000													11	11					0	0	1	0	0
HAO2	51179	broad.mit.edu	37	1	119923749	119923749	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:119923749G>A	ENST00000361035.4	+	3	363	c.80G>A	c.(79-81)cGa>cAa	p.R27Q	HAO2_ENST00000325945.3_Missense_Mutation_p.R14Q	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	14	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity	p.R14L(1)		breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		GCCCATGCGCGAGAGCAGCTG	0.468000													135	44					0	0	1	0	0
KLHL41	10324	broad.mit.edu	37	2	170366325	170366325	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:170366325C>T	ENST00000284669.1	+	1	114	c.37C>T	c.(37-39)Ctt>Ttt	p.L13F	BBS5_ENST00000554017.1_Intron|RP11-724O16.1_ENST00000513963.1_Intron	NM_006063.2	NP_006054.2			kelch-like family member 41																		GGAACTGCGGCTTTACCAATC	0.488000													39	53					0	0	1	0	0
SGSM2	9905	broad.mit.edu	37	17	2276740	2276740	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:2276740C>T	ENST00000268989.3	+	17	2210	c.2033C>T	c.(2032-2034)tCc>tTc	p.S678F	SGSM2_ENST00000574563.1_Missense_Mutation_p.S633F|SGSM2_ENST00000426855.2_Missense_Mutation_p.S633F	NM_014853.2	NP_055668.2	O43147	SGSM2_HUMAN	small G protein signaling modulator 2	633	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				Colorectal(2;5.15e-05)|READ - Rectum adenocarcinoma(2;0.000115)		ACCAAGTTCTCCTCAGGCAGC	0.652000													20	9					0	0	1	0	0
SERPINB12	89777	broad.mit.edu	37	18	61233847	61233847	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:61233847G>A	ENST00000382768.1	+	7	881	c.881G>A	c.(880-882)aGg>aAg	p.R294K	SERPINB12_ENST00000269491.1_Missense_Mutation_p.R274K			Q96P63	SPB12_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 12	274					negative regulation of protein catabolic process|regulation of proteolysis	cytoplasm	enzyme binding|serine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(5)|lung(19)|skin(1)	26						TAGCTTGAAAGGAAAATCACC	0.468000													58	69					0	0	1	0	0
STIL	6491	broad.mit.edu	37	1	47735460	47735460	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:47735460G>A	ENST00000360380.3	-	15	2825	c.2462C>T	c.(2461-2463)tCc>tTc	p.S821F	STIL_ENST00000396221.2_Missense_Mutation_p.S821F|STIL_ENST00000371877.3_Missense_Mutation_p.S821F|STIL_ENST00000337817.5_Missense_Mutation_p.S821F|STIL_ENST00000243182.6_Missense_Mutation_p.S821F			Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus	821					cell proliferation|multicellular organismal development	centrosome|cytosol				central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)	36		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				GTCCTCACTGGAAATTTTGGT	0.373000													56	28					0	0	1	0	0
PDE4C	5143	broad.mit.edu	37	19	18333048	18333048	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:18333048G>A	ENST00000355502.3	-	6	1199	c.328C>T	c.(328-330)Cca>Tca	p.P110S	PDE4C_ENST00000447275.2_Missense_Mutation_p.P4S|PDE4C_ENST00000262805.11_Missense_Mutation_p.P78S|PDE4C_ENST00000594617.2_Missense_Mutation_p.P110S|PDE4C_ENST00000594465.2_Missense_Mutation_p.P110S			Q08493	PDE4C_HUMAN	phosphodiesterase 4C, cAMP-specific	110					signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding	p.P110S(1)		breast(2)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(2)|lung(9)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33					Dyphylline(DB00651)	TGCGGGACTGGAGCCTGCATA	0.622000													29	24					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35402022	35402022	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:35402022C>T	ENST00000453357.2	+	1	113	c.57C>T	c.(55-57)ttC>ttT	p.F19F	UNC5D_ENST00000420357.1_Intron|UNC5D_ENST00000416672.1_Intron|UNC5D_ENST00000287272.2_Intron|UNC5D_ENST00000404895.2_Intron			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	0					apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CTTCCGGGTTCCTGTTGGACT	0.418000													20	33					0	0	1	0	0
OR4N4	283694	broad.mit.edu	37	15	22382680	22382680	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:22382680G>A	ENST00000328795.4	+	1	299	c.208G>A	c.(208-210)Gat>Aat	p.D70N	RP11-69H14.6_ENST00000558896.1_RNA	NM_001005241.2	NP_001005241.2	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N, member 4	70					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(19)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	40		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GGCCTTCCTGGATGCATCCTA	0.473000													19	115					0	0	1	0	0
DUSP22	56940	broad.mit.edu	37	6	350830	350830	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:350830G>A	ENST00000344450.5	+	8	960	c.517G>A	c.(517-519)Gga>Aga	p.G173R	DUSP22_ENST00000419235.2_3'UTR|DUSP22_ENST00000604971.1_3'UTR	NM_020185.3	NP_064570.1	Q9NRW4	DUS22_HUMAN	dual specificity phosphatase 22	173					apoptosis|cell proliferation|inactivation of MAPK activity|multicellular organismal development|positive regulation of JNK cascade|regulation of cell proliferation|transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(2)	26	all_hematologic(77;0.228)	Breast(5;0.0249)|all_hematologic(90;0.0489)		OV - Ovarian serous cystadenocarcinoma(45;0.0277)|BRCA - Breast invasive adenocarcinoma(62;0.0669)		AGCCGCTCCGGGAATTCTGAA	0.403000													20	47					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206590788	206590788	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:206590788C>T	ENST00000360409.3	+	6	1763	c.972C>T	c.(970-972)tcC>tcT	p.S324S	NRP2_ENST00000540841.1_Silent_p.S324S|NRP2_ENST00000412873.2_Silent_p.S324S|NRP2_ENST00000417189.1_Silent_p.S324S|NRP2_ENST00000357118.4_Silent_p.S324S|NRP2_ENST00000540178.1_Silent_p.S324S|NRP2_ENST00000355117.4_Silent_p.S324S|NRP2_ENST00000272849.3_Silent_p.S324S|NRP2_ENST00000357785.5_Silent_p.S324S	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	324	F5/8 type C 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						ACTTGGATTCCAACAAGGAGT	0.512000													23	37					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25472080	25472080	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:25472080G>A	ENST00000453082.2	+	0	1122					NR_003343.1																						GACCCCGGAGGAAAATTTGTG	0.622000													4	6					0	0	1	0	0
C1orf94	84970	broad.mit.edu	37	1	34663306	34663306	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:34663306G>A	ENST00000488417.1	+	2	921	c.801G>A	c.(799-801)aaG>aaA	p.K267K	C1orf94_ENST00000373374.3_Silent_p.K77K	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	77							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				GGGTCACCAAGGACTTCCTAC	0.572000													14	60					0	0	1	0	0
PRR18	285800	broad.mit.edu	37	6	166720853	166720853	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:166720853C>T	ENST00000322583.3	-	1	1018	c.778G>A	c.(778-780)Gag>Aag	p.E260K		NM_175922.3	NP_787118.2	Q8N4B5	PRR18_HUMAN	proline rich 18	260						endoplasmic reticulum				haematopoietic_and_lymphoid_tissue(2)|lung(1)	3		Breast(66;2.35e-05)|Ovarian(120;0.0606)|Prostate(117;0.0959)		OV - Ovarian serous cystadenocarcinoma(33;1.5e-19)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;7.96e-05)		ACCAGGCCCTCGTCCACCGCC	0.741000													9	6					0	0	1	0	0
STEAP3	55240	broad.mit.edu	37	2	120003271	120003271	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:120003271C>T	ENST00000354888.5	+	3	703	c.199C>T	c.(199-201)Ctg>Ttg	p.L67L	STEAP3_ENST00000393107.2_Silent_p.L67L|STEAP3_ENST00000393110.2_Silent_p.L77L|STEAP3_ENST00000393106.2_Silent_p.L67L|STEAP3-AS1_ENST00000454260.1_RNA|STEAP3_ENST00000409811.1_Silent_p.L67L|STEAP3_ENST00000450943.2_Silent_p.L67L|STEAP3_ENST00000425223.2_Silent_p.L67L|STEAP3_ENST00000393108.2_Silent_p.L67L	NM_182915.2	NP_878919.2	Q658P3	STEA3_HUMAN	STEAP family member 3, metalloreductase	67					apoptosis|cell cycle|cellular iron ion homeostasis|protein secretion|transferrin transport|transmembrane transport	endosome membrane|integral to membrane|multivesicular body	electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(2)|lung(4)|skin(1)	17						CACAGCCAGGCTGTTTCCCTC	0.627000													14	27					0	0	1	0	0
MROH1	727957	broad.mit.edu	37	8	145218744	145218744	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:145218744C>T	ENST00000528919.1	+	2	136	c.15C>T	c.(13-15)tcC>tcT	p.S5S	MROH1_ENST00000398656.4_Silent_p.S5S|MROH1_ENST00000326134.5_Silent_p.S5S|MROH1_ENST00000423230.2_Silent_p.S5S|MROH1_ENST00000534366.1_Silent_p.S5S	NM_032450.2	NP_115826.2			maestro heat-like repeat family member 1																		CTGAGTCCTCCATGAAGAGTG	0.512000													16	31					0	0	1	0	0
P2RY12	64805	broad.mit.edu	37	3	151056565	151056565	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:151056565G>A	ENST00000302632.3	-	3	368	c.69C>T	c.(67-69)atC>atT	p.I23I	MED12L_ENST00000273432.4_Intron|MED12L_ENST00000474524.1_Intron|MED12L_ENST00000491549.1_Intron	NM_022788.4|NM_176876.2	NP_073625.1|NP_795345.1	Q9H244	P2Y12_HUMAN	purinergic receptor P2Y, G-protein coupled, 12	23					platelet activation	integral to membrane|plasma membrane	guanyl-nucleotide exchange factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)	17			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)		Clopidogrel(DB00758)|Epoprostenol(DB01240)|Ticlopidine(DB00208)|Treprostinil(DB00374)	GGACCTGGGTGATTTTGTAGT	0.468000													12	26					0	0	1	0	0
CYSLTR2	57105	broad.mit.edu	37	13	49281733	49281733	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:49281733C>T	ENST00000282018.3	+	1	783	c.780C>T	c.(778-780)ttC>ttT	p.F260F		NM_020377.2	NP_065110.1	Q9NS75	CLTR2_HUMAN	cysteinyl leukotriene receptor 2	260					immune response	integral to membrane|plasma membrane				endometrium(2)|large_intestine(4)|lung(12)|skin(2)	20		all_cancers(8;1.66e-53)|all_epithelial(8;1.96e-19)|all_lung(13;9.94e-09)|all_hematologic(8;7.13e-07)|Lung NSC(96;1.72e-06)|Breast(56;1.53e-05)|Acute lymphoblastic leukemia(8;6.86e-05)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0416)|Lung SC(185;0.0787)		GBM - Glioblastoma multiforme(99;1.19e-09)	Nedocromil(DB00716)	TCTTGTGTTTCCTGCCCTATC	0.488000													15	47					0	0	1	0	0
CRISPLD2	83716	broad.mit.edu	37	16	84940205	84940205	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:84940205C>T	ENST00000262424.5	+	15	1675	c.1451C>T	c.(1450-1452)cCt>cTt	p.P484L	CRISPLD2_ENST00000567845.1_Missense_Mutation_p.P483L	NM_031476.3	NP_113664.1	Q9H0B8	CRLD2_HUMAN	cysteine-rich secretory protein LCCL domain containing 2	484	LCCL 2.					extracellular region|transport vesicle				endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)	18						CTGGGGACTCCTCGGGATGGA	0.582000													25	56					0	0	1	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3140012	3140012	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:3140012C>T	ENST00000252463.2	-	5	1345	c.1258G>A	c.(1258-1260)Gat>Aat	p.D420N	ZSCAN10_ENST00000538082.2_Missense_Mutation_p.D338N|ZSCAN10_ENST00000575108.1_Missense_Mutation_p.D81N	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	420					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						CACAGGACATCGGTCAGTGGC	0.706000													4	12					0	0	1	0	0
KNSTRN	90417	broad.mit.edu	37	15	40675049	40675049	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:40675049G>A	ENST00000416151.2	+	1	128	c.13G>A	c.(13-15)Gaa>Aaa	p.E5K	KNSTRN_ENST00000249776.8_Missense_Mutation_p.E5K|KNSTRN_ENST00000448395.2_Missense_Mutation_p.E5K	NM_001142761.1	NP_001136233.1			kinetochore-localized astrin/SPAG5 binding protein																		GGCGGCTCCCGAAGCCCCGCC	0.582000													4	2					0	0	1	0	0
KRT13	3860	broad.mit.edu	37	17	39661453	39661453	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:39661453G>A	ENST00000246635.3	-	1	396	c.350C>T	c.(349-351)tCc>tTc	p.S117F	KRT13_ENST00000336861.3_Missense_Mutation_p.S117F|KRT13_ENST00000587544.1_Missense_Mutation_p.S117F	NM_153490.2	NP_705694.2	P13646	K1C13_HUMAN	keratin 13	117	Coil 1A.|Rod.				epidermis development	intermediate filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	33		Breast(137;0.000286)				CTCCAGGTAGGAAGCCAGGCG	0.597000													66	85					0	0	1	0	0
PTPRN2	5799	broad.mit.edu	37	7	157926383	157926383	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:157926383G>A	ENST00000389413.3	-	9	1645	c.1542C>T	c.(1540-1542)atC>atT	p.I514I	PTPRN2_ENST00000389418.4_Silent_p.I514I|PTPRN2_ENST00000404321.2_Silent_p.I537I|PTPRN2_ENST00000409483.1_Silent_p.I476I|PTPRN2_ENST00000389416.4_Silent_p.I497I	NM_130843.2	NP_570858.2	Q92932	PTPR2_HUMAN	protein tyrosine phosphatase, receptor type, N polypeptide 2	514						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.I514I(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(1)|lung(42)|ovary(4)|pleura(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	86	all_neural(206;0.181)	all_cancers(7;8.99e-13)|all_epithelial(9;2.4e-06)|all_hematologic(28;0.0155)|Breast(660;0.132)	OV - Ovarian serous cystadenocarcinoma(82;0.00463)	STAD - Stomach adenocarcinoma(7;0.0875)		TGTCTGTCACGATGTAGCCCC	0.657000													32	54					0	0	1	0	0
LOC101927209	101927209	broad.mit.edu	37	1	142713786	142713786	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:142713786C>T	ENST00000369381.2	-	0	819																											TGTCATTTTTCATTGTGCATA	0.289000													11	42					0	0	1	0	0
B4GALNT4	338707	broad.mit.edu	37	11	376088	376088	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:376088C>T	ENST00000329962.6	+	12	1110	c.1110C>T	c.(1108-1110)ttC>ttT	p.F370F		NM_178537.4	NP_848632.2	Q76KP1	B4GN4_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 4	370						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			endometrium(2)|kidney(4)|large_intestine(1)|liver(2)|lung(7)|ovary(2)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACCTGTCCTTCGTTTATCCCA	0.682000													5	15					0	0	1	0	0
WDR33	55339	broad.mit.edu	37	2	128471302	128471302	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:128471302G>A	ENST00000322313.4	-	18	3321	c.3163C>T	c.(3163-3165)Ccc>Tcc	p.P1055S		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	1055					postreplication repair|spermatogenesis	collagen|nucleus	protein binding	p.P1055S(1)		NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		TGATCAGGGGGAAACGGAGGC	0.652000													62	100					0	0	1	0	0
RHPN1	114822	broad.mit.edu	37	8	144464755	144464755	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:144464755C>T	ENST00000289013.6	+	15	2048	c.1947C>T	c.(1945-1947)tgC>tgT	p.C649C		NM_052924.2	NP_443156.2	Q8TCX5	RHPN1_HUMAN	rhophilin, Rho GTPase binding protein 1	674					signal transduction	intracellular				endometrium(1)|large_intestine(1)|lung(7)	9	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			CTGGAGGCTGCCCCCAGCCCT	0.687000													16	22					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38770294	38770294	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:38770294G>A	ENST00000449082.2	-	15	2378	c.2379C>T	c.(2377-2379)atC>atT	p.I793I		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	793					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TGATGGCCAGGATGATGGTGA	0.512000													33	34					0	0	1	0	0
RPS7	6201	broad.mit.edu	37	2	3624082	3624082	+	Silent	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:3624082T>A	ENST00000407445.3	+	4	200	c.153T>A	c.(151-153)atT>atA	p.I51I	RPS7_ENST00000304921.5_Silent_p.I51I|RPS7_ENST00000403564.1_Silent_p.I51I|RPS7_ENST00000406376.1_Silent_p.I51I			P62081	RS7_HUMAN	ribosomal protein S7	51					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	90S preribosome|cytosolic small ribosomal subunit|nucleolus|small-subunit processome	protein binding|RNA binding|structural constituent of ribosome			endometrium(1)|lung(2)|urinary_tract(1)	4	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0963)|Epithelial(75;0.208)		TTTAGGAAATTGAAGTTGGTG	0.393000													16	76					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104121068	104121068	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:104121068C>T	ENST00000388887.2	+	47	5079	c.4875C>T	c.(4873-4875)gtC>gtT	p.V1625V		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	1625	FAS1 5.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AAGATCTGGTCGGCCCAGGCC	0.527000													57	156					0	0	1	0	0
BMP6	654	broad.mit.edu	37	6	7861759	7861759	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:7861759G>A	ENST00000283147.6	+	3	1092	c.933G>A	c.(931-933)acG>acA	p.T311T		NM_001718.4	NP_001709.1	P22004	BMP6_HUMAN	bone morphogenetic protein 6	311					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(6)|ovary(1)|prostate(1)	23	Ovarian(93;0.0721)					TTGACATCACGGCCACTAGCA	0.498000													43	112					0	0	1	0	0
KMT2B	9757	broad.mit.edu	37	19	36223189	36223189	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:36223189C>T	ENST00000222270.7	+	28	5739	c.5739C>T	c.(5737-5739)tcC>tcT	p.S1913S	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000420124.1_Silent_p.S1913S	NM_014727.1	NP_055542.1																					CCAGACGTTCCCGTCGTCCCA	0.647000													8	11					0	0	1	0	0
EFCAB13	124989	broad.mit.edu	37	17	45456607	45456607	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:45456607C>T	ENST00000331493.2	+	14	1981	c.1570C>T	c.(1570-1572)Cct>Tct	p.P524S	EFCAB13_ENST00000517484.1_Missense_Mutation_p.P428S	NM_152347.4	NP_689560.3			EF-hand calcium binding domain 13																		GCGAAGTTTTCCTGAATGCAA	0.368000													19	33					0	0	1	0	0
ILDR2	387597	broad.mit.edu	37	1	166890214	166890214	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:166890214C>T	ENST00000271417.3	-	9	1669	c.1614G>A	c.(1612-1614)cgG>cgA	p.R538R	ILDR2_ENST00000528703.1_Silent_p.R479R|ILDR2_ENST00000525740.1_Silent_p.R411R|ILDR2_ENST00000529071.1_Silent_p.R519R|ILDR2_ENST00000469934.2_Intron|ILDR2_ENST00000529387.1_Intron|ILDR2_ENST00000526687.1_Silent_p.R430R	NM_199351.2	NP_955383.1	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor 2	538						integral to membrane				NS(3)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	22						CGCCCTCGGGCCGCGCCTGGC	0.761000													3	6					0	0	1	0	0
MYO1A	4640	broad.mit.edu	37	12	57430816	57430816	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:57430816C>T	ENST00000442789.2	-	21	2402	c.2115G>A	c.(2113-2115)caG>caA	p.Q705Q	MYO1A_ENST00000544473.1_Silent_p.Q543Q|MYO1A_ENST00000300119.3_Silent_p.Q705Q	NM_001256041.1	NP_001242970.1	Q9UBC5	MYO1A_HUMAN	myosin IA	705	IQ 1.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(12)|lung(17)|ovary(2)|skin(7)|urinary_tract(3)	50						GGTAAATCTTCTGTATGAGTG	0.552000													26	69					0	0	1	0	0
MAGEB16	139604	broad.mit.edu	37	X	35820576	35820576	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:35820576G>A	ENST00000399989.1	+	2	542	c.263G>A	c.(262-264)aGc>aAc	p.S88N	MAGEB16_ENST00000399985.1_Missense_Mutation_p.S88N|MAGEB16_ENST00000399988.1_Missense_Mutation_p.S88N|MAGEB16_ENST00000399987.1_Missense_Mutation_p.S88N|MAGEB16_ENST00000399992.1_Missense_Mutation_p.S120N	NM_001099921.1	NP_001093391.1	A2A368	MAGBG_HUMAN	melanoma antigen family B, 16	88										breast(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						GAGGCTTCCAGCAATCAAGAA	0.507000													8	1					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9068396	9068396	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:9068396G>A	ENST00000397910.4	-	3	19253	c.19050C>T	c.(19048-19050)tcC>tcT	p.S6350S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6352	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCATCGCAGAGGATCTAGGCA	0.458000													22	19					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101581230	101581230	+	Silent	SNP	G	G	A	rs147034851	byFrequency	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:101581230G>A	ENST00000536262.2	-	7	1455	c.897C>T	c.(895-897)ctC>ctT	p.L299L		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	299					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						AATATAGGGCGAGCCCACAAA	0.453000													17	28					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54786195	54786195	+	Missense_Mutation	SNP	C	C	T	rs61735063	byFrequency	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:54786195C>T	ENST00000218436.6	-	7	1098	c.1069G>A	c.(1069-1071)Gat>Aat	p.D357N		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	357	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										TTACAGCCATCGGCTTCCATG	0.498000													15	3					0	0	1	0	0
USP6	9098	broad.mit.edu	37	17	5050466	5050466	+	Missense_Mutation	SNP	C	C	T	rs139533846		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:5050466C>T	ENST00000574788.1	+	29	4638	c.2408C>T	c.(2407-2409)tCa>tTa	p.S803L	USP6_ENST00000332776.4_Intron|USP6_ENST00000304328.5_Missense_Mutation_p.S486L|USP6_ENST00000250066.6_Missense_Mutation_p.S803L			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	803					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						TCTCCAATTTCAGCTTCTAGT	0.358000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								35	19					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34149336	34149336	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:34149336G>A	ENST00000346193.3	-	1	1111	c.1060C>T	c.(1060-1062)Cct>Tct	p.P354S		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	354								p.P354T(1)		NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						GTCTCGGAAGGCTCCGAGCGG	0.652000													17	34					0	0	1	0	0
POU3F4	5456	broad.mit.edu	37	X	82763888	82763888	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:82763888G>A	ENST00000373200.2	+	1	620	c.556G>A	c.(556-558)Gag>Aag	p.E186K	RP3-326L13.2_ENST00000607095.1_RNA	NM_000307.3	NP_000298.2	P49335	PO3F4_HUMAN	POU class 3 homeobox 4	186	POU-specific.				sensory perception of sound	nucleus	sequence-specific DNA binding transcription factor activity			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	37						TCACTCCGACGAGGAGACGCC	0.602000													22	1					0	0	1	0	0
PLEKHA5	54477	broad.mit.edu	37	12	19506821	19506821	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:19506821C>T	ENST00000538714.1	+	22	2703	c.2699C>T	c.(2698-2700)tCc>tTc	p.S900F	PLEKHA5_ENST00000317589.4_Missense_Mutation_p.S905F|PLEKHA5_ENST00000539256.1_Missense_Mutation_p.S600F|PLEKHA5_ENST00000543806.1_Missense_Mutation_p.S824F|PLEKHA5_ENST00000424268.1_Missense_Mutation_p.S831F|PLEKHA5_ENST00000359180.3_Missense_Mutation_p.S786F|PLEKHA5_ENST00000299275.6_Missense_Mutation_p.S842F|PLEKHA5_ENST00000429027.2_Missense_Mutation_p.S1008F|PLEKHA5_ENST00000355397.3_Missense_Mutation_p.S900F	NM_001143821.2	NP_001137293.2	Q9HAU0	PKHA5_HUMAN	pleckstrin homology domain containing, family A member 5	842							1-phosphatidylinositol binding|protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.00804)					TTTTTAGGTTCCCACTTTCCT	0.348000													19	17					0	0	1	0	0
OR8B8	26493	broad.mit.edu	37	11	124310278	124310278	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:124310278G>A	ENST00000328064.2	-	1	776	c.704C>T	c.(703-705)tCc>tTc	p.S235F		NM_012378.1	NP_036510.1	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B, member 8	235					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		GAAGGCTTTGGACCTGCCCTC	0.473000													52	69					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179498800	179498800	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179498800C>T	ENST00000589042.1	-	231	42650	c.42426G>A	c.(42424-42426)ctG>ctA	p.L14142L	TTN_ENST00000342992.6_Silent_p.L11574L|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Silent_p.L12501L|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.L5077L|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Silent_p.L5269L|TTN_ENST00000359218.5_Silent_p.L5202L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12501	Fibronectin type-III 2.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACATGAATTTCAGTCTTATAC	0.363000													15	28					0	0	1	0	0
KLK4	9622	broad.mit.edu	37	19	51412005	51412005	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:51412005G>A	ENST00000324041.1	-	3	304	c.305C>T	c.(304-306)tCc>tTc	p.S102F	KLK4_ENST00000431178.2_Missense_Mutation_p.S53F	NM_004917.3	NP_004908.3	Q9Y5K2	KLK4_HUMAN	kallikrein-related peptidase 4	102	Peptidase S1.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(8)	19		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00624)|GBM - Glioblastoma multiforme(134;0.00878)		GTGCCGTACGGAGAGGCTGGC	0.617000													11	45					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228547941	228547941	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:228547941G>A	ENST00000284548.11	+	81	19422	c.19348G>A	c.(19348-19350)Ggg>Agg	p.G6450R	OBSCN_ENST00000570156.2_Intron|OBSCN_ENST00000366707.4_Intron|OBSCN_ENST00000366709.4_Missense_Mutation_p.G3569R|OBSCN_ENST00000422127.1_Intron			Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	0					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				ACACAGCCTTGGGGATCGTGA	0.627000													7	57					0	0	1	0	0
ZNF652	22834	broad.mit.edu	37	17	47376064	47376064	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:47376064G>A	ENST00000362063.2	-	6	1850	c.1532C>T	c.(1531-1533)tCc>tTc	p.S511F	ZNF652_ENST00000430262.2_Missense_Mutation_p.S511F	NM_014897.2	NP_055712.1	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	511	Mediates interaction with CBFA2T3.|Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	20	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			GGTGGCTGGGGAAGTTGTAAG	0.562000													19	45					0	0	1	0	0
BPIFB2	80341	broad.mit.edu	37	20	31598902	31598902	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:31598902G>A	ENST00000170150.3	+	3	377	c.182G>A	c.(181-183)gGa>gAa	p.G61E		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	61						extracellular region	lipid binding										GACTGGAGTGGAGAGGCGCTT	0.612000													26	88					0	0	1	0	0
TRABD2A	129293	broad.mit.edu	37	2	85097363	85097363	+	Silent	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:85097363A>G	ENST00000335459.5	-	2	860	c.655T>C	c.(655-657)Ttg>Ctg	p.L219L	TRABD2A_ENST00000409133.1_Silent_p.L219L|TRABD2A_ENST00000409520.2_Silent_p.L219L	NM_001080824.1	NP_001074293.1			TraB domain containing 2A																		GAAAAGTTCAACCCATTCAAT	0.498000													57	127					0	0	1	0	0
SRGAP3	9901	broad.mit.edu	37	3	9166411	9166411	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:9166411G>A	ENST00000383836.3	-	2	685	c.258C>T	c.(256-258)ttC>ttT	p.F86F	SRGAP3_ENST00000360413.3_Silent_p.F86F|SRGAP3_ENST00000433332.3_5'UTR	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	86	FCH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		CTTCTTACTTGAACTGGTGCT	0.592000			T	RAF1	pilocytic astrocytoma								30	37					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22206685	22206685	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:22206685G>A	ENST00000374695.3	-	17	2337	c.2258C>T	c.(2257-2259)cCt>cTt	p.P753L		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	753	Laminin EGF-like 1; second part.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGGCCCACCAGGCACCCGAGT	0.602000													9	60					0	0	1	0	0
EPB41L5	57669	broad.mit.edu	37	2	120834850	120834850	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:120834850C>T	ENST00000263713.5	+	9	886	c.672C>T	c.(670-672)gcC>gcT	p.A224A	EPB41L5_ENST00000443124.1_Silent_p.A224A|EPB41L5_ENST00000443902.2_Silent_p.A224A|EPB41L5_ENST00000452780.1_Silent_p.A224A|EPB41L5_ENST00000331393.4_Silent_p.A224A	NM_020909.3	NP_065960.2	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	224	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(12)|ovary(1)	26						TGAATAAAGCCAAATGGCTAG	0.318000													35	28					0	0	1	0	0
DPCR1	135656	broad.mit.edu	37	6	30920202	30920202	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:30920202C>T	ENST00000462446.1	+	2	3989	c.3961C>T	c.(3961-3963)Cct>Tct	p.P1321S	DPCR1_ENST00000304311.2_Missense_Mutation_p.P163S|HCG21_ENST00000419481.1_RNA			Q3MIW9	DPCR1_HUMAN	diffuse panbronchiolitis critical region 1	445						integral to membrane				endometrium(1)|kidney(2)|large_intestine(3)|lung(3)|pancreas(1)	10						TGATTCATTCCCTGCATGGGC	0.502000													34	55					0	0	1	0	0
EIF4G1	1981	broad.mit.edu	37	3	184039114	184039114	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:184039114C>T	ENST00000342981.4	+	9	1156	c.742C>T	c.(742-744)Cct>Tct	p.P248S	EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000427845.1_Missense_Mutation_p.P161S|EIF4G1_ENST00000434061.2_Missense_Mutation_p.P52S|EIF4G1_ENST00000319274.6_Missense_Mutation_p.P248S|EIF4G1_ENST00000411531.1_Missense_Mutation_p.P208S|EIF4G1_ENST00000346169.2_Missense_Mutation_p.P248S|EIF4G1_ENST00000382330.3_Missense_Mutation_p.P255S|EIF4G1_ENST00000414031.1_Missense_Mutation_p.P208S|EIF4G1_ENST00000424196.1_Missense_Mutation_p.P255S|EIF4G1_ENST00000350481.5_Missense_Mutation_p.P84S|EIF4G1_ENST00000435046.2_Missense_Mutation_p.P52S|EIF4G1_ENST00000441154.1_Missense_Mutation_p.P84S|EIF4G1_ENST00000392537.2_Missense_Mutation_p.P161S|EIF4G1_ENST00000352767.3_Missense_Mutation_p.P255S	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	248					insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			GCCAGGGCTGCCTGGCCCAGA	0.567000													34	89					0	0	1	0	0
LCE2C	353140	broad.mit.edu	37	1	152648614	152648614	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:152648614C>T	ENST00000368783.1	+	2	178	c.123C>T	c.(121-123)ttC>ttT	p.F41F	LCE2B_ENST00000417924.2_Intron	NM_178429.2	NP_848516.1	Q5TA81	LCE2C_HUMAN	late cornified envelope 2C	41	Cys-rich.				keratinization					endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)	13	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCCATGTTTCCCTGCAGTCT	0.627000													36	198					0	0	1	0	0
GNAT1	2779	broad.mit.edu	37	3	50232275	50232275	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:50232275G>A	ENST00000232461.3	+	8	1054	c.940G>A	c.(940-942)Gag>Aag	p.E314K	GNAT1_ENST00000433068.1_Missense_Mutation_p.E314K	NM_144499.2	NP_653082.1	P11488	GNAT1_HUMAN	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1	314					detection of chemical stimulus involved in sensory perception of bitter taste|G-protein signaling, coupled to cAMP nucleotide second messenger|negative regulation of cyclic-nucleotide phosphodiesterase activity|rhodopsin mediated phototransduction|sensory perception of umami taste	heterotrimeric G-protein complex|photoreceptor inner segment|photoreceptor outer segment membrane	acyl binding|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GDP binding|GTP binding|GTPase activity|protein kinase binding|signal transducer activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		CGACGTGAAGGAGATCTATTC	0.567000											OREG0015580	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	45					0	0	1	0	0
CBLN2	147381	broad.mit.edu	37	18	70205951	70205951	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:70205951C>T	ENST00000269503.4	-	4	1187	c.414G>A	c.(412-414)ccG>ccA	p.P138P	CBLN2_ENST00000583651.1_5'UTR|CBLN2_ENST00000585159.1_Silent_p.P138P|CBLN2_ENST00000581073.1_Silent_p.P24P|CBLN2_ENST00000584764.1_Silent_p.P22P	NM_182511.3	NP_872317.1	Q8IUK8	CBLN2_HUMAN	cerebellin 2 precursor	138	C1q.					integral to membrane				endometrium(2)|lung(15)	17		Esophageal squamous(42;0.131)				TCCCTTTTCTCGGTGCTACAA	0.428000													27	43					0	0	1	0	0
MOXD1	26002	broad.mit.edu	37	6	132694079	132694079	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:132694079G>A	ENST00000367963.3	-	3	587	c.469C>T	c.(469-471)Ccc>Tcc	p.P157S	MOXD1_ENST00000336749.3_Missense_Mutation_p.P89S	NM_015529.2	NP_056344.2	Q6UVY6	MOXD1_HUMAN	monooxygenase, DBH-like 1	157					catecholamine metabolic process	endoplasmic reticulum membrane|integral to membrane	copper ion binding|dopamine beta-monooxygenase activity			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|ovary(1)|prostate(3)|skin(1)	37	Breast(56;0.0495)			OV - Ovarian serous cystadenocarcinoma(155;0.0132)|GBM - Glioblastoma multiforme(226;0.0191)		TGGTACTTGGGACCAGCTTCT	0.483000													19	66					0	0	1	0	0
MIA3	375056	broad.mit.edu	37	1	222823646	222823646	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:222823646A>G	ENST00000344922.5	+	9	3669	c.3644A>G	c.(3643-3645)cAa>cGa	p.Q1215R	MIA3_ENST00000344441.6_Missense_Mutation_p.Q1215R|MIA3_ENST00000340535.7_Missense_Mutation_p.Q93R|MIA3_ENST00000344507.1_Intron	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	1215					exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		ACGGAACAGCAAATTTCTGAG	0.274000													12	6					0	0	1	0	0
CFHR4	10877	broad.mit.edu	37	1	196874364	196874364	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:196874364C>T	ENST00000367416.2	+	3	517	c.380C>T	c.(379-381)tCt>tTt	p.S127F	CFHR4_ENST00000251424.4_Intron|CFHR4_ENST00000367418.1_Intron|CFHR2_ENST00000367421.3_Intron	NM_001201550.2|NM_001201551.1	NP_001188479.1|NP_001188480.1			complement factor H-related 4											NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	36						GAGGGAAATTCTTCAGGATCA	0.308000													84	42					0	0	1	0	0
SCN1A	6323	broad.mit.edu	37	2	166870396	166870396	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:166870396C>T	ENST00000423058.2	-	18	3580	c.3563G>A	c.(3562-3564)aGa>aAa	p.R1188K	AC010127.3_ENST00000597623.1_RNA|AC010127.3_ENST00000595647.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.R1160K|SCN1A_ENST00000375405.3_Missense_Mutation_p.R1177K|SCN1A_ENST00000303395.4_Missense_Mutation_p.R1188K	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1188						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	ACACTTGAATCTTTGTACACA	0.378000													42	62					0	0	1	0	0
ACACA	31	broad.mit.edu	37	17	35634798	35634798	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:35634798G>A	ENST00000353139.5	-	6	1192	c.711C>T	c.(709-711)atC>atT	p.I237I	ACACA_ENST00000360679.3_Silent_p.I142I|ACACA_ENST00000394406.2_Silent_p.I200I|ACACA_ENST00000335166.5_Silent_p.I122I	NM_198834.1|NM_198839.1	NP_942131.1|NP_942136.1	Q13085	ACACA_HUMAN	acetyl-CoA carboxylase alpha	200	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(2)|breast(5)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(24)|lung(23)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	83		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CTTGTACTGGGATCCTTTTAG	0.368000													14	24					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6694443	6694443	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:6694443C>T	ENST00000245907.6	-	24	3245	c.3154_splice	c.e24+1	p.K1051_splice		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1051					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GGAGCCCACCCTTCTTGATGA	0.622000													12	35					0	0	1	0	0
AKAP3	10566	broad.mit.edu	37	12	4736883	4736883	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:4736883C>T	ENST00000545990.2	-	5	1709	c.1185G>A	c.(1183-1185)agG>agA	p.R395R	AKAP3_ENST00000228850.1_Silent_p.R395R	NM_001278309.1	NP_001265238.1	O75969	AKAP3_HUMAN	A kinase (PRKA) anchor protein 3	395					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|liver(1)|lung(17)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	51						CTTGGGCTTTCCTGACATGCT	0.433000													36	43					0	0	1	0	0
GNAS	2778	broad.mit.edu	37	20	57429101	57429101	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:57429101T>A	ENST00000371100.4	+	1	1333	c.781T>A	c.(781-783)Tcg>Acg	p.S261T	GNAS_ENST00000306120.3_Silent_p.P197P|GNAS_ENST00000603534.1_Intron|GNAS_ENST00000313949.7_Intron|GNAS_ENST00000371099.2_Missense_Mutation_p.S261T|GNAS_ENST00000371098.2_Intron|GNAS_ENST00000371102.4_Missense_Mutation_p.S261T|GNAS_ENST00000464624.2_3'UTR|GNAS_ENST00000371075.3_Intron	NM_001077490.1|NM_080425.2	NP_001070958.1|NP_536350.2	P63092	GNAS2_HUMAN	GNAS complex locus	0					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity			adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			AGTCGCGGCCTCGAGTGCGGT	0.667000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			19	13					0	0	1	0	0
SOCS1	8651	broad.mit.edu	37	16	11348858	11348858	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:11348858G>A	ENST00000332029.2	-	2	628	c.478C>T	c.(478-480)Cgc>Tgc	p.R160C	RMI2_ENST00000572173.1_Intron	NM_003745.1	NP_003736.1	O15524	SOCS1_HUMAN	suppressor of cytokine signaling 1	160	SH2.				interferon-gamma-mediated signaling pathway|JAK-STAT cascade|negative regulation of insulin receptor signaling pathway|negative regulation of tyrosine phosphorylation of Stat3 protein|regulation of growth|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol	insulin-like growth factor receptor binding|protein kinase binding|protein kinase inhibitor activity	p.F144fs*34(1)|p.Y64fs*1(1)|p.R127_*212del(1)|p.0?(1)|p.P158_M161del(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(66)|lung(3)	71						CCCAGCATGCGGCGCGGCGCC	0.736000			"""F, O"""		"""Hodgkin Lymphoma, PMBL"""								5	16					0	0	1	0	0
CEACAM8	1088	broad.mit.edu	37	19	43092991	43092991	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:43092991G>A	ENST00000244336.5	-	4	1004	c.903C>T	c.(901-903)acC>acT	p.T301T	CEACAM8_ENST00000599005.1_Intron|LIPE-AS1_ENST00000594688.1_RNA|LIPE-AS1_ENST00000594624.2_RNA	NM_001816.3	NP_001807.2	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 8	301	Ig-like C2-type 2.				immune response	anchored to membrane|extracellular space|integral to plasma membrane				endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	16		Prostate(69;0.00899)				CTGAGTTAGTGGTGTGGCAGG	0.488000													38	66					0	0	1	0	0
LAPTM5	7805	broad.mit.edu	37	1	31212743	31212743	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:31212743G>A	ENST00000294507.3	-	4	374	c.300C>T	c.(298-300)atC>atT	p.I100I		NM_006762.2	NP_006753.1	Q13571	LAPM5_HUMAN	lysosomal protein transmembrane 5	100					transport	integral to plasma membrane|lysosomal membrane				large_intestine(2)|lung(7)|skin(1)	10		Colorectal(325;0.0199)|Myeloproliferative disorder(586;0.0393)|all_neural(195;0.0966)|Medulloblastoma(700;0.151)|Ovarian(437;0.192)		STAD - Stomach adenocarcinoma(196;0.0196)|READ - Rectum adenocarcinoma(331;0.0649)		GATAGTCCATGATTTGCAGGG	0.612000													5	36					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38739366	38739366	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:38739366C>T	ENST00000449082.2	-	27	5344	c.5345G>A	c.(5344-5346)cGa>cAa	p.R1782Q		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1782					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	CAGTATATTTCGATTGGGTTT	0.473000													7	59					0	0	1	0	0
GPX5	2880	broad.mit.edu	37	6	28500114	28500114	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:28500114G>A	ENST00000412168.2	+	4	465	c.376G>A	c.(376-378)Gga>Aga	p.G126R	GPX5_ENST00000469384.1_Silent_p.G86G|GPX5_ENST00000442674.2_3'UTR	NM_001509.2	NP_001500.1	O75715	GPX5_HUMAN	glutathione peroxidase 5 (epididymal androgen-related protein)	126					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			endometrium(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16					Glutathione(DB00143)	CCGTCCAGGGGGAGGATTTGT	0.428000													48	81					0	0	1	0	0
CCDC174	51244	broad.mit.edu	37	3	14712622	14712622	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:14712622C>T	ENST00000383794.3	+	11	1398	c.1325C>T	c.(1324-1326)cCc>cTc	p.P442L	CCDC174_ENST00000303688.7_Missense_Mutation_p.P366L	NM_016474.4	NP_057558.3			coiled-coil domain containing 174																		ACTCCTGCCCCCGACAACCCA	0.542000													27	45					0	0	1	0	0
OR5K1	26339	broad.mit.edu	37	3	98188467	98188467	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:98188467G>A	ENST00000332650.5	+	1	144	c.47G>A	c.(46-48)gGa>gAa	p.G16E		NM_001004736.2	NP_001004736.2	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K, member 1	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(4)|lung(21)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						ATCCTCACAGGATTTACAGAT	0.388000													48	78					0	0	1	0	0
HMHA1	23526	broad.mit.edu	37	19	1068708	1068708	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:1068708G>A	ENST00000313093.2	+	2	617	c.386G>A	c.(385-387)gGc>gAc	p.G129D	HMHA1_ENST00000590214.1_Missense_Mutation_p.G156D|HMHA1_ENST00000536472.1_Intron|HMHA1_ENST00000539243.2_Missense_Mutation_p.G145D|HMHA1_ENST00000586866.1_Missense_Mutation_p.G133D	NM_012292.3	NP_036424.2	Q92619	HMHA1_HUMAN	histocompatibility (minor) HA-1	129					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|lung(7)|ovary(1)|prostate(2)	16		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTCGCTGAGGGCCTTGAGAAA	0.672000													39	47					0	0	1	0	0
DGCR2	9993	broad.mit.edu	37	22	19028787	19028787	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:19028787G>A	ENST00000263196.7	-	9	1427	c.1180C>T	c.(1180-1182)Cgc>Tgc	p.R394C	DGCR2_ENST00000545799.1_3'UTR|DGCR2_ENST00000537045.1_Missense_Mutation_p.R353C	NM_001184781.1|NM_005137.2	NP_001171710.1|NP_005128.1	P98153	IDD_HUMAN	DiGeorge syndrome critical region gene 2	394					cell adhesion|organ morphogenesis	integral to membrane	receptor activity|sugar binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(1)	18	Colorectal(54;0.0993)					GGGATCCTGCGGCCGAGGTTG	0.622000													25	44					0	0	1	0	0
RDX	5962	broad.mit.edu	37	11	110104138	110104138	+	Missense_Mutation	SNP	G	G	A	rs138560358	byFrequency	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:110104138G>A	ENST00000343115.4	-	13	1730	c.1411C>T	c.(1411-1413)Cct>Tct	p.P471S	RDX_ENST00000544551.1_Missense_Mutation_p.P335S|RDX_ENST00000530301.1_Intron|RDX_ENST00000528498.1_Missense_Mutation_p.P471S|RDX_ENST00000528900.1_Missense_Mutation_p.P124S|RDX_ENST00000405097.1_Missense_Mutation_p.P471S	NM_001260494.1|NM_002906.3	NP_001247423.1|NP_002897.1	P35241	RADI_HUMAN	radixin	471	Glu-rich.|Poly-Pro.				actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	18		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		GGAGGTGGAGGGGGGGCAGAC	0.428000													45	84					0	0	1	0	0
HCRTR2	3062	broad.mit.edu	37	6	55119933	55119933	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:55119933G>A	ENST00000370862.3	+	3	738		c.e3-1			NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2						feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CTTTTCTCTAGACCGTGTCGG	0.403000													32	16					0	0	1	0	0
CXCL9	4283	broad.mit.edu	37	4	76924771	76924771	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:76924771G>A	ENST00000264888.5	-	4	396	c.358C>T	c.(358-360)Cgt>Tgt	p.R120C	RP11-630D6.5_ENST00000501239.2_RNA	NM_002416.1	NP_002407.1	Q07325	CXCL9_HUMAN	chemokine (C-X-C motif) ligand 9	120					cell-cell signaling|cellular defense response|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response	extracellular space	chemokine activity			large_intestine(3)|liver(1)|lung(5)|ovary(1)|skin(1)	11			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TTCTTTTGACGAGAACGTTGA	0.348000													26	23					0	0	1	0	0
UNC13A	23025	broad.mit.edu	37	19	17753740	17753740	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:17753740C>T	ENST00000428389.2	-	21	2649	c.2650G>A	c.(2650-2652)Ggt>Agt	p.G884S	UNC13A_ENST00000552293.1_Missense_Mutation_p.G796S|UNC13A_ENST00000551649.1_Missense_Mutation_p.G796S|UNC13A_ENST00000550896.1_Missense_Mutation_p.G794S|UNC13A_ENST00000252773.7_Missense_Mutation_p.G796S|UNC13A_ENST00000519716.2_Missense_Mutation_p.G796S			Q9UPW8	UN13A_HUMAN	unc-13 homolog A (C. elegans)	796					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(11)|lung(31)|ovary(5)|prostate(2)	61						CGGATGGCACCCGACACGGCA	0.507000													5	11					0	0	1	0	0
PLEKHA8P1	51054	broad.mit.edu	37	12	45567046	45567046	+	RNA	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:45567046A>G	ENST00000256692.5	-	0	1639					NR_037144.1															breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(10)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						CTGCATCCCAATACTGAAAGC	0.498000													18	50					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158497676	158497676	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:158497676G>A	ENST00000355585.4	+	17	2386	c.2311G>A	c.(2311-2313)Gaa>Aaa	p.E771K	SYNJ2_ENST00000367121.3_Missense_Mutation_p.E771K|SYNJ2_ENST00000367122.2_Missense_Mutation_p.E771K	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	771							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		GGACTTTCACGAAGGAGCCAT	0.463000													52	49					0	0	1	0	0
GLRA3	8001	broad.mit.edu	37	4	175688129	175688129	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:175688129G>A	ENST00000274093.3	-	3	754	c.252C>T	c.(250-252)atC>atT	p.I84I	GLRA3_ENST00000340217.5_Silent_p.I84I	NM_006529.2	NP_006520.2	O75311	GLRA3_HUMAN	glycine receptor, alpha 3	84					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			endometrium(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	35		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	TCGTCTCTGCGATAGAGCCAA	0.358000													9	50					0	0	1	0	0
TUBA8	51807	broad.mit.edu	37	22	18613784	18613784	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:18613784G>A	ENST00000330423.3	+	5	1304	c.1231G>A	c.(1231-1233)Gag>Aag	p.E411K	TUBA8_ENST00000316027.6_Missense_Mutation_p.E345K	NM_018943.2	NP_061816.1	Q9NY65	TBA8_HUMAN	tubulin, alpha 8	411					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)	14						GTATGTGGGAGAGGGGATGGA	0.542000													37	52					0	0	1	0	0
PLA2G15	23659	broad.mit.edu	37	16	68289196	68289196	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:68289196C>T	ENST00000219345.5	+	4	498	c.415C>T	c.(415-417)Cac>Tac	p.H139Y	PLA2G15_ENST00000566188.1_Missense_Mutation_p.H139Y|PLA2G15_ENST00000413021.2_Silent_p.S86S|PLA2G15_ENST00000444212.2_Intron	NM_012320.3	NP_036452.1	Q8NCC3	PAG15_HUMAN	phospholipase A2, group XV	139					fatty acid catabolic process	extracellular region|lysosome	lysophospholipase activity|phosphatidylcholine-sterol O-acyltransferase activity|phospholipid binding			kidney(2)|large_intestine(2)|lung(2)|ovary(2)|prostate(3)|skin(1)	12						TTCCTATTTCCACACCATGGT	0.557000													20	23					0	0	1	0	0
OR4X2	119764	broad.mit.edu	37	11	48267036	48267036	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:48267036C>T	ENST00000302329.3	+	1	429	c.381C>T	c.(379-381)atC>atT	p.I127I		NM_001004727.1	NP_001004727.1	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X, member 2	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(4)|lung(12)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)	20						ACACCACCATCATGAACTGGC	0.498000													48	55					0	0	1	0	0
PPP1R1A	5502	broad.mit.edu	37	12	54975916	54975916	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:54975916C>T	ENST00000257905.8	-	5	418		c.e5-1		PPP1R1A_ENST00000547431.1_Intron	NM_006741.3	NP_006732.3	Q13522	PPR1A_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 1A						glycogen metabolic process|signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity			lung(2)	2						ATCTGGAGCTCTGGGGACACA	0.592000													3	12					0	0	1	0	0
PLA2R1	22925	broad.mit.edu	37	2	160876730	160876730	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:160876730G>A	ENST00000283243.7	-	8	1545	c.1339C>T	c.(1339-1341)Cca>Tca	p.P447S	PLA2R1_ENST00000392771.1_Missense_Mutation_p.P447S	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	447	C-type lectin 2.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						AAGGAAACTGGAATTTTATTG	0.363000													18	21					0	0	1	0	0
GBP1	2633	broad.mit.edu	37	1	89520410	89520410	+	Silent	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:89520410G>T	ENST00000370473.4	-	10	1839	c.1620C>A	c.(1618-1620)gtC>gtA	p.V540V	GBP1_ENST00000484970.1_5'UTR	NM_002053.2	NP_002044.2	P32455	GBP1_HUMAN	guanylate binding protein 1, interferon-inducible	540					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(7)|kidney(4)|large_intestine(8)|lung(6)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	30		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		TCAGCAACTGGACCCTGTCGT	0.433000													265	117					2.53866e-96	2.5793e-96	1	1	0
LRP1B	53353	broad.mit.edu	37	2	141460033	141460033	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:141460033C>T	ENST00000389484.3	-	38	7084	c.6113G>A	c.(6112-6114)gGa>gAa	p.G2038E		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2038					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCATGCTATTCCCATGCTTAC	0.423000										TSP Lung(27;0.18)			21	39					0	0	1	0	0
RMDN2	151393	broad.mit.edu	37	2	38201340	38201340	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:38201340C>T	ENST00000407257.1	+	3	1291	c.1144C>T	c.(1144-1146)Cgt>Tgt	p.R382C	RMDN2_ENST00000354545.2_Missense_Mutation_p.R204C|RMDN2_ENST00000406384.1_Missense_Mutation_p.R204C|RMDN2_ENST00000234195.3_Missense_Mutation_p.R382C|RMDN2_ENST00000417700.2_Missense_Mutation_p.R59C|RMDN2-AS1_ENST00000414365.2_RNA					regulator of microtubule dynamics 2																		TGAACTACTTCGTGACCACAA	0.338000													15	18					0	0	1	0	0
XCR1	2829	broad.mit.edu	37	3	46063269	46063269	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:46063269C>T	ENST00000309285.3	-	2	527	c.171G>A	c.(169-171)gtG>gtA	p.V57V	XCR1_ENST00000542109.1_Silent_p.V57V	NM_001024644.1	NP_001019815.1	P46094	XCR1_HUMAN	chemokine (C motif) receptor 1	57					chemotaxis|G-protein signaling, coupled to cyclic nucleotide second messenger|inflammatory response	integral to plasma membrane	chemokine receptor activity			NS(2)|endometrium(2)|kidney(2)|large_intestine(1)|lung(3)|ovary(1)|pancreas(1)|prostate(2)	14				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		TCTCATACTTCACCAGGACCC	0.572000													30	31					0	0	1	0	0
EDC4	23644	broad.mit.edu	37	16	67913599	67913599	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:67913599C>T	ENST00000358933.5	+	15	1982	c.1743C>T	c.(1741-1743)ttC>ttT	p.F581F	EDC4_ENST00000574770.1_3'UTR	NM_014329.4	NP_055144.3	Q6P2E9	EDC4_HUMAN	enhancer of mRNA decapping 4	581					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(8)|ovary(4)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0042)|Epithelial(162;0.0185)|all cancers(182;0.121)		CTGCCGACTTCCTCAGTCTGA	0.632000													68	95					0	0	1	0	0
TMPRSS9	360200	broad.mit.edu	37	19	2408441	2408441	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:2408441C>T	ENST00000332578.3	+	7	828	c.828C>T	c.(826-828)gtC>gtT	p.V276V		NM_182973.1	NP_892018.1	Q7Z410	TMPS9_HUMAN	transmembrane protease, serine 9	276	Peptidase S1 1.				proteolysis	integral to plasma membrane	serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	29				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAGGTGGTCCAGATCGTCA	0.657000													62	71					0	0	1	0	0
SNAP91	9892	broad.mit.edu	37	6	84292048	84292048	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:84292048G>A	ENST00000428679.2	-	23	2635	c.2042C>T	c.(2041-2043)tCc>tTc	p.S681F	SNAP91_ENST00000521743.1_Missense_Mutation_p.S681F|SNAP91_ENST00000521485.1_Missense_Mutation_p.S681F|SNAP91_ENST00000369694.2_Missense_Mutation_p.S681F|SNAP91_ENST00000195649.6_Missense_Mutation_p.S681F|SNAP91_ENST00000437520.1_Missense_Mutation_p.S374F|SNAP91_ENST00000520213.1_Missense_Mutation_p.S374F|SNAP91_ENST00000439399.2_Missense_Mutation_p.S681F|SNAP91_ENST00000520302.1_Missense_Mutation_p.S651F			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	681					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		TGGAGATGGGGAAGGCGCCAT	0.433000													9	40					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179437688	179437688	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:179437688G>A	ENST00000367618.3	+	17	2296	c.1909G>A	c.(1909-1911)Gaa>Aaa	p.E637K	AXDND1_ENST00000457238.2_3'UTR|AXDND1_ENST00000461179.2_3'UTR	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	637										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						GGAAATAGATGAAAAAATTAA	0.353000													37	21					0	0	1	0	0
CCDC57	284001	broad.mit.edu	37	17	80085758	80085758	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:80085758G>A	ENST00000392347.1	-	16	2412	c.2376C>T	c.(2374-2376)acC>acT	p.T792T	CCDC57_ENST00000392346.2_Silent_p.T149T|CCDC57_ENST00000389641.4_Silent_p.T792T	NM_198082.2	NP_932348.2	Q2TAC2	CCD57_HUMAN	coiled-coil domain containing 57	792										endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	16	Breast(20;0.00285)|all_neural(118;0.0878)|all_lung(278;0.0949)|Lung NSC(278;0.128)|Ovarian(332;0.227)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0253)			GTGATTTACAGGTCACCGTGT	0.572000													44	41					0	0	1	0	0
NCAPG	64151	broad.mit.edu	37	4	17826621	17826621	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:17826621C>T	ENST00000251496.2	+	10	1590	c.1414C>T	c.(1414-1416)Ccc>Tcc	p.P472S		NM_022346.3	NP_071741.2	Q9BPX3	CND3_HUMAN	non-SMC condensin I complex, subunit G	472					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	27				STAD - Stomach adenocarcinoma(129;0.18)		GATTCGGGCGCCCATTGTTAC	0.328000													23	10					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56539859	56539859	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:56539859C>G	ENST00000390649.3	+	7	2260	c.2260C>G	c.(2260-2262)Cct>Gct	p.P754A		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	754						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		TGAGGCATGTCCTGTGGTCCC	0.522000													52	79					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135692306	135692306	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:135692306G>A	ENST00000513104.1	-	2	1052	c.770C>T	c.(769-771)aCt>aTt	p.T257I	TRPC7_ENST00000426057.2_Missense_Mutation_p.T257I|TRPC7_ENST00000355180.3_Missense_Mutation_p.T257I	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	257					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CTTAAATTCAGTCTCAATGTT	0.542000													6	16					0	0	1	0	0
CCDC102B	79839	broad.mit.edu	37	18	66564554	66564554	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:66564554G>A	ENST00000360242.5	+	6	1269	c.1152G>A	c.(1150-1152)aaG>aaA	p.K384K	CCDC102B_ENST00000319445.6_Silent_p.K384K|CCDC102B_ENST00000358653.5_Silent_p.K384K|CCDC102B_ENST00000584156.1_Silent_p.K384K|CCDC102B_ENST00000577772.1_3'UTR	NM_024781.2	NP_079057.2	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	384										breast(2)|endometrium(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|stomach(1)	36		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				GAAGGCTGAAGATCCAGGTGA	0.398000													56	63					0	0	1	0	0
ZNF852	285346	broad.mit.edu	37	3	44540638	44540638	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:44540638C>T	ENST00000436261.1	-	4	1791	c.1631G>A	c.(1630-1632)tGa>tAa	p.*544*				B6EU87	B6EU87_HUMAN	zinc finger protein 852	0					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|lung(5)	8						CAGCTTAACTCAAAGGTCTTT	0.458000													3	8					0	0	1	0	0
ARHGAP36	158763	broad.mit.edu	37	X	130217164	130217164	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:130217164C>T	ENST00000276211.5	+	3	624	c.279C>T	c.(277-279)acC>acT	p.T93T	ARHGAP36_ENST00000370922.1_Silent_p.T81T	NM_144967.3	NP_659404.2	Q6ZRI8	RHG36_HUMAN	Rho GTPase activating protein 36	93					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(1)|central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(16)|lung(31)|ovary(4)|prostate(4)|skin(3)|urinary_tract(2)	71						GTCCGAACACCTTGGATAAGT	0.413000													39	7					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2911389	2911389	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:2911389G>A	ENST00000254695.8	+	17	1534	c.1444G>A	c.(1444-1446)Gag>Aag	p.E482K	RAP1GAP2_ENST00000542807.1_Missense_Mutation_p.E482K|RAP1GAP2_ENST00000366401.4_Missense_Mutation_p.E467K|RAP1GAP2_ENST00000540393.2_Missense_Mutation_p.E463K	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	482					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						GGGCCCAGAGGAGGACAAGTT	0.592000													26	21					0	0	1	0	0
LINC00359	100887754	broad.mit.edu	37	13	97600346	97600346	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:97600346C>T	ENST00000442322.1	-	0	171																											GAAATGTCTTCTGATTTTCTT	0.393000													7	11					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159687216	159687216	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:159687216C>T	ENST00000297267.9	+	21	5585	c.5385C>T	c.(5383-5385)ttC>ttT	p.F1795F	FNDC1_ENST00000340366.6_Silent_p.F1732F	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	1795						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		ATCGAAAGTTCGTGGGAGTTG	0.473000													51	52					0	0	1	0	0
KLK2	3817	broad.mit.edu	37	19	51380002	51380002	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:51380002G>A	ENST00000325321.3	+	3	706	c.481G>A	c.(481-483)Gaa>Aaa	p.E161K	KLK2_ENST00000391810.2_Missense_Mutation_p.E59K|KLK2_ENST00000358049.4_Missense_Mutation_p.E161K			P20151	KLK2_HUMAN	kallikrein-related peptidase 2	161	Peptidase S1.				proteolysis		serine-type endopeptidase activity		KLK2/ETV1(3)|KLK2/ETV4(2)	large_intestine(3)|lung(6)|ovary(1)|skin(1)	11		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.00871)		GGGCAGCATCGAACCAGAGGA	0.642000			T	ETV4	prostate								7	22					0	0	1	0	0
IL17C	27189	broad.mit.edu	37	16	88705706	88705706	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:88705706C>T	ENST00000244241.4	+	2	373	c.324C>T	c.(322-324)ccC>ccT	p.P108P		NM_013278.3	NP_037410.1	Q9P0M4	IL17C_HUMAN	interleukin 17C	108					cell surface receptor linked signaling pathway|cell-cell signaling|inflammatory response	extracellular space|soluble fraction	cytokine activity			large_intestine(1)|lung(1)	2				BRCA - Breast invasive adenocarcinoma(80;0.0477)		CCATCTCACCCTGGAGATACC	0.701000													8	25					0	0	1	0	0
TRPC6	7225	broad.mit.edu	37	11	101344500	101344500	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:101344500C>T	ENST00000344327.3	-	7	2173	c.1749G>A	c.(1747-1749)agG>agA	p.R583R	TRPC6_ENST00000348423.4_Silent_p.R467R|TRPC6_ENST00000532133.1_Silent_p.R505R|TRPC6_ENST00000360497.4_Silent_p.R528R	NM_004621.5	NP_004612.2	Q9Y210	TRPC6_HUMAN	transient receptor potential cation channel, subfamily C, member 6	583					axon guidance|platelet activation|positive regulation of calcium ion transport via store-operated calcium channel activity	integral to membrane|plasma membrane	protein binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(14)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		Acute lymphoblastic leukemia(157;0.000918)|all_hematologic(158;0.0162)		BRCA - Breast invasive adenocarcinoma(274;0.0442)		CCCACTTTATCCTGGCTAGGA	0.333000													15	50					0	0	1	0	0
SERPINA7	6906	broad.mit.edu	37	X	105277523	105277523	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:105277523G>A	ENST00000327674.4	-	4	1551	c.1216C>T	c.(1216-1218)Cta>Tta	p.L406L	SERPINA7_ENST00000372563.1_Silent_p.L406L			P05543	THBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	406					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(14)|ovary(1)|skin(3)	24					Levothyroxine(DB00451)|Liothyronine(DB00279)	ACTTTCCCTAGAAAGAGAATA	0.388000													44	75					0	0	1	0	0
LILRA2	11027	broad.mit.edu	37	19	55086445	55086445	+	Silent	SNP	G	G	A	rs141931276		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:55086445G>A	ENST00000251377.3	+	5	733	c.600G>A	c.(598-600)tcG>tcA	p.S200S	LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRA2_ENST00000251376.3_Silent_p.S200S|LILRA2_ENST00000391737.1_Silent_p.S188S|LILRB1_ENST00000396321.2_Intron|LILRA2_ENST00000391738.3_Silent_p.S200S					leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2											breast(1)|endometrium(2)|kidney(4)|large_intestine(2)|lung(33)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50				GBM - Glioblastoma multiforme(193;0.0963)		CTTATGACTCGAACTCTCCCT	0.577000													38	94					0	0	1	0	0
PDGFRA	5156	broad.mit.edu	37	4	55146569	55146569	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:55146569G>A	ENST00000257290.5	+	16	2574	c.2243G>A	c.(2242-2244)aGg>aAg	p.R748K	FIP1L1_ENST00000507166.1_Missense_Mutation_p.R508K	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	748	Protein kinase.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	ATGCTAGAAAGGAAAGAGGTT	0.368000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			23	16					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166924569	166924569	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:166924569G>A	ENST00000061240.2	+	6	1306	c.659G>A	c.(658-660)gGa>gAa	p.G220E	TLL1_ENST00000513213.1_Missense_Mutation_p.G220E|TLL1_ENST00000507499.1_Missense_Mutation_p.G220E	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	220	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GGTCGGCGAGGAAATGGACCT	0.438000													47	21					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176760566	176760566	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:176760566C>T	ENST00000367662.3	+	19	6132	c.4968C>T	c.(4966-4968)ccC>ccT	p.P1656P		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1656	Poly-Pro.|Sushi 5.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						GCCCACCACCCCCCTCAGAGC	0.428000													42	23					0	0	1	0	0
VPRBP	9730	broad.mit.edu	37	3	51458162	51458162	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:51458162G>A	ENST00000335891.5	-	7	924	c.915C>T	c.(913-915)atC>atT	p.I305I				Q9Y4B6	VPRBP_HUMAN	Vpr (HIV-1) binding protein	754					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	41				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		CCAGGGCCCGGATTTGGTCTG	0.557000													27	139					0	0	1	0	0
BRINP3	339479	broad.mit.edu	37	1	190067958	190067958	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:190067958C>T	ENST00000367462.3	-	8	1722	c.1491G>A	c.(1489-1491)atG>atA	p.M497I	FAM5C_ENST00000484105.1_5'UTR|FAM5C_ENST00000534846.1_Missense_Mutation_p.M395I	NM_199051.1	NP_950252.1	Q76B58	FAM5C_HUMAN		497						extracellular region				NS(1)|breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(18)|lung(98)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(7)|urinary_tract(2)	164	Prostate(682;0.198)					GCAGATATTTCATCTCGAGAT	0.498000													142	70					0	0	1	0	0
IDO1	3620	broad.mit.edu	37	8	39781028	39781028	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:39781028G>A	ENST00000518237.1	+	7	1217	c.578G>A	c.(577-579)cGg>cAg	p.R193Q	RP11-44K6.3_ENST00000517623.1_RNA|IDO1_ENST00000522495.1_Missense_Mutation_p.R193Q	NM_002164.5	NP_002155.1	P14902	I23O1_HUMAN	indoleamine 2,3-dioxygenase 1	193					female pregnancy|tryptophan catabolic process	cytosol	electron carrier activity|heme binding|indoleamine 2,3-dioxygenase activity|tryptophan 2,3-dioxygenase activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(2)	12					L-Tryptophan(DB00150)	ATGCAAGAACGGGACACTTTG	0.373000													3	23					0	0	1	0	0
DMP1	1758	broad.mit.edu	37	4	88584383	88584383	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:88584383G>A	ENST00000339673.6	+	6	1552	c.1453G>A	c.(1453-1455)Gag>Aag	p.E485K	DMP1_ENST00000282479.7_Missense_Mutation_p.E469K|RP11-742B18.1_ENST00000507894.1_RNA|RP11-742B18.1_ENST00000506480.1_RNA	NM_004407.3	NP_004398.1	Q13316	DMP1_HUMAN	dentin matrix acidic phosphoprotein 1	485					biomineral tissue development|ossification	cytoplasm|nucleus|proteinaceous extracellular matrix	calcium ion binding|integrin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|pancreas(3)|prostate(1)|skin(1)|stomach(1)	32		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.227)		OV - Ovarian serous cystadenocarcinoma(123;0.000516)		GAAAAACATTGAGATAGAGAG	0.463000													114	65					0	0	1	0	0
BTF3	689	broad.mit.edu	37	5	72800226	72800226	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:72800226C>T	ENST00000380591.3	+	5	791	c.572C>T	c.(571-573)cCa>cTa	p.P191L	BTF3_ENST00000335895.8_Missense_Mutation_p.P147L|BTF3_ENST00000514505.2_3'UTR	NM_001037637.1	NP_001032726.1	P20290	BTF3_HUMAN	basic transcription factor 3	191					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding			endometrium(1)|large_intestine(2)|lung(2)	5		Lung NSC(167;0.00405)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;2.73e-54)		GATGAAGTTCCAGGTAGGAAC	0.383000													19	12					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881601	228881601	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:228881601G>A	ENST00000392056.3	-	7	4015	c.3969C>T	c.(3967-3969)atC>atT	p.I1323I	SPHKAP_ENST00000344657.5_Silent_p.I1323I	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1323						cytoplasm	protein binding	p.I1323I(1)		NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CATCCACAATGATTTTGTTCT	0.493000													20	42					0	0	1	0	0
FBXL7	23194	broad.mit.edu	37	5	15936912	15936912	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:15936912G>A	ENST00000504595.1	+	4	1574	c.1093G>A	c.(1093-1095)Gac>Aac	p.D365N	FBXL7_ENST00000329673.7_Missense_Mutation_p.D353N|FBXL7_ENST00000510662.1_Missense_Mutation_p.D318N	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	365					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						CCGGGTCACCGACGTGGGCAT	0.677000													7	4					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154855984	154855984	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:154855984G>A	ENST00000460393.1	+	9	934	c.814G>A	c.(814-816)Gaa>Aaa	p.E272K	MME_ENST00000462745.1_Missense_Mutation_p.E272K|MME_ENST00000360490.2_Missense_Mutation_p.E272K|MME_ENST00000493237.1_Missense_Mutation_p.E272K|MME_ENST00000492661.1_Missense_Mutation_p.E272K	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	272					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	GCTTGCTTTGGAAATGAATAA	0.358000													35	41					0	0	1	0	0
GCNT2	2651	broad.mit.edu	37	6	10556735	10556735	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:10556735T>A	ENST00000316170.3	+	1	496	c.79T>A	c.(79-81)Ttt>Att	p.F27I	GCNT2_ENST00000495262.1_Intron|GCNT2_ENST00000397423.2_Intron|GCNT2_ENST00000410107.1_Intron|GCNT2_ENST00000379597.3_Intron	NM_001491.2	NP_001482.1	Q8N0V5	GNT2A_HUMAN	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)	28						Golgi membrane|integral to membrane	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(2)|ovary(2)	12	Ovarian(93;0.107)|Breast(50;0.148)	all_hematologic(90;0.107)		KIRC - Kidney renal clear cell carcinoma(1;0.099)|Kidney(1;0.119)		TGTGTTCAATTTTGGGGGAGA	0.388000													44	36					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27702397	27702397	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:27702397G>A	ENST00000438700.3	-	1	900	c.783C>T	c.(781-783)ctC>ctT	p.L261L		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	261					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						GGGGCACGCAGAGCGCCCTGT	0.637000													8	16					0	0	1	0	0
ZFPM2	23414	broad.mit.edu	37	8	106813841	106813841	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:106813841C>T	ENST00000407775.2	+	8	1781	c.1531C>T	c.(1531-1533)Cct>Tct	p.P511S	RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000520492.1_Missense_Mutation_p.P379S|ZFPM2_ENST00000522296.1_3'UTR|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|ZFPM2_ENST00000378472.4_Missense_Mutation_p.P242S|RP11-152P17.2_ENST00000520594.1_RNA|ZFPM2_ENST00000517361.1_Missense_Mutation_p.P379S|RP11-152P17.2_ENST00000520433.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	511					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			CACCATGGTCCCTCAAGCTTC	0.493000													34	125					0	0	1	0	0
PPARGC1A	10891	broad.mit.edu	37	4	23803489	23803489	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:23803489G>A	ENST00000264867.2	-	12	2276	c.2157C>T	c.(2155-2157)ttC>ttT	p.F719F	PPARGC1A_ENST00000509702.1_5'UTR	NM_013261.3	NP_037393.1	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	719	RRM.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|liver(1)|lung(24)|ovary(3)|skin(5)	51		Breast(46;0.0503)				GGTAGGTAATGAAACCATAGC	0.408000													25	8					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152711441	152711441	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:152711441G>A	ENST00000367255.5	-	53	8752	c.8151C>T	c.(8149-8151)atC>atT	p.I2717I	SYNE1_ENST00000423061.1_Silent_p.I2724I|SYNE1_ENST00000265368.4_Silent_p.I2717I|SYNE1_ENST00000341594.5_Silent_p.I2756I|SYNE1_ENST00000448038.1_Silent_p.I2724I	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2717					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGGAGCTCATGATGTCAGCCC	0.458000										HNSCC(10;0.0054)			17	35					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90049464	90049464	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:90049464C>T	ENST00000405460.2	+	54	11291	c.11195C>T	c.(11194-11196)tCa>tTa	p.S3732L		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3732	Calx-beta 24.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CCAGAGTTATCAGAGGTTGTG	0.378000													25	55					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128341877	128341877	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:128341877C>T	ENST00000389524.4	+	13	1577	c.1524C>T	c.(1522-1524)tcC>tcT	p.S508S	MYO7B_ENST00000409816.2_Silent_p.S508S|MYO7B_ENST00000428314.1_Silent_p.S508S			Q6PIF6	MYO7B_HUMAN	myosin VIIB	508	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GCATCATCTCCCTCCTGGACG	0.607000													23	57					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228881722	228881722	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:228881722G>A	ENST00000392056.3	-	7	3894	c.3848C>T	c.(3847-3849)tCc>tTc	p.S1283F	SPHKAP_ENST00000344657.5_Missense_Mutation_p.S1283F	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	1283						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCAGAGACCGGATGAGGACGC	0.502000													34	49					0	0	1	0	0
LYSMD1	388695	broad.mit.edu	37	1	151133436	151133436	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:151133436G>A	ENST00000368908.5	-	3	1266	c.606C>T	c.(604-606)gtC>gtT	p.V202V	LYSMD1_ENST00000440902.2_Silent_p.V154V	NM_212551.4	NP_997716.1	Q96S90	LYSM1_HUMAN	LysM, putative peptidoglycan-binding, domain containing 1	202					cell wall macromolecule catabolic process					endometrium(2)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CAGGACCTAGGACTGCTCGTT	0.572000													31	80					0	0	1	0	0
GPR179	440435	broad.mit.edu	37	17	36489278	36489278	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:36489278G>A	ENST00000342292.4	-	10	1913	c.1893C>T	c.(1891-1893)ttC>ttT	p.F631F		NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	631						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CCAGCTTCCAGAACTGGCAGG	0.607000													14	21					0	0	1	0	0
MYH15	22989	broad.mit.edu	37	3	108117636	108117636	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:108117636C>T	ENST00000273353.3	-	36	5097	c.5041G>A	c.(5041-5043)Gag>Aag	p.E1681K		NM_014981.1	NP_055796.1	Q9Y2K3	MYH15_HUMAN	myosin, heavy chain 15	1681						myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						GCCACCTGCTCCTTCAGATCA	0.537000													58	114					0	0	1	0	0
GLP1R	2740	broad.mit.edu	37	6	39047409	39047409	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:39047409G>A	ENST00000373256.4	+	11	1156	c.1113G>A	c.(1111-1113)atG>atA	p.M371I		NM_002062.3	NP_002053.3	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor	371					activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			breast(5)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	31					Exenatide(DB01276)|Glucagon recombinant(DB00040)	CCTTTGTGATGGACGAGCACG	0.562000													16	66					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	101847245	101847245	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:101847245G>A	ENST00000369138.1	+	1	582	c.92G>A	c.(91-93)gGa>gAa	p.G31E	GRIK2_ENST00000369137.3_Missense_Mutation_p.G31E|GRIK2_ENST00000421544.1_Missense_Mutation_p.G31E|GRIK2_ENST00000318991.6_Missense_Mutation_p.G31E|GRIK2_ENST00000413795.1_Missense_Mutation_p.G31E|GRIK2_ENST00000358361.3_Missense_Mutation_p.G31E	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	31					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TATTCTCAAGGAACCACACAT	0.468000													9	85					0	0	1	0	0
ANGPT1	284	broad.mit.edu	37	8	108264126	108264126	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:108264126G>A	ENST00000520734.1	-	8	1139	c.854C>T	c.(853-855)tCc>tTc	p.S285F	ANGPT1_ENST00000518386.1_5'UTR|ANGPT1_ENST00000520052.1_Missense_Mutation_p.S284F			Q15389	ANGP1_HUMAN	angiopoietin 1	485	Fibrinogen C-terminal.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|blood coagulation|cell differentiation|heparin biosynthetic process|leukocyte migration|negative regulation of cell adhesion|negative regulation of endothelial cell apoptosis|negative regulation of vascular permeability|positive chemotaxis|positive regulation of blood vessel endothelial cell migration|positive regulation of ERK1 and ERK2 cascade|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of protein ubiquitination|positive regulation of receptor internalization|protein localization at cell surface|regulation of satellite cell proliferation|sprouting angiogenesis|Tie receptor signaling pathway	extracellular space|membrane raft|microvillus|plasma membrane	receptor tyrosine kinase binding			NS(1)|breast(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(13)|ovary(4)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	43	Breast(1;5.06e-08)		OV - Ovarian serous cystadenocarcinoma(57;5.53e-09)			GGAACGTAAGGAGTAACTGGG	0.433000													53	61					0	0	1	0	0
EXD2	55218	broad.mit.edu	37	14	69704396	69704396	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:69704396C>T	ENST00000409014.1	+	10	1679	c.1022C>T	c.(1021-1023)tCc>tTc	p.S341F	EXD2_ENST00000312994.5_Missense_Mutation_p.S466F|EXD2_ENST00000492815.1_3'UTR|EXD2_ENST00000409018.3_Missense_Mutation_p.S466F|EXD2_ENST00000449989.1_Missense_Mutation_p.S341F|EXD2_ENST00000409242.1_Missense_Mutation_p.S341F|EXD2_ENST00000409949.1_Missense_Mutation_p.S341F|EXD2_ENST00000409675.1_Missense_Mutation_p.S341F	NM_001193360.1	NP_001180289.1	Q9NVH0	EXD2_HUMAN	exonuclease 3'-5' domain containing 2	341					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			breast(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(7)|prostate(1)|urinary_tract(1)	14						CATGCCATTTCCAACTACTAT	0.572000													33	1					0	0	1	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217315660	217315660	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:217315660C>T	ENST00000357276.4	+	12	2273	c.1943C>T	c.(1942-1944)tCc>tTc	p.S648F	SMARCAL1_ENST00000358207.5_Missense_Mutation_p.S648F	NM_014140.3	NP_054859.2	Q9NZC9	SMAL1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1	648					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(10)|liver(1)|lung(15)|ovary(3)|prostate(1)|skin(1)	42		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CGCCTCAAGTCCGACGTCCTT	0.612000									Schimke Immuno-Osseous Dysplasia				39	55					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10916378	10916378	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:10916378G>A	ENST00000298232.7	-	19	1581	c.1214C>T	c.(1213-1215)tCg>tTg	p.S405L	TPTE_ENST00000361285.4_Missense_Mutation_p.S423L|TPTE_ENST00000415664.2_Intron|TPTE_ENST00000342420.5_Missense_Mutation_p.S385L	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	423					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.S405L(2)		NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ACGAGGAATCGAATAAATAAT	0.388000													10	57					0	0	1	0	0
BMP5	653	broad.mit.edu	37	6	55638912	55638912	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:55638912C>T	ENST00000370830.3	-	4	1660	c.962G>A	c.(961-963)cGa>cAa	p.R321Q	BMP5_ENST00000446683.2_Missense_Mutation_p.R321Q	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	321					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity	p.R321Q(1)		cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			TTGATTTTTTCGTTTGTTGGC	0.478000													52	35					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179588342	179588342	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179588342C>T	ENST00000589042.1	-	74	21709	c.21485G>A	c.(21484-21486)gGa>gAa	p.G7162E	TTN_ENST00000342992.6_Missense_Mutation_p.G5918E|TTN_ENST00000591111.1_Missense_Mutation_p.G6845E|RP11-171I2.1_ENST00000590024.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6845	Ig-like 53.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGAGGGGTTCCTCTAATAAC	0.438000													8	10					0	0	1	0	0
EPB41L4B	54566	broad.mit.edu	37	9	112015735	112015735	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:112015735T>C	ENST00000374566.3	-	12	1782	c.1265A>G	c.(1264-1266)cAt>cGt	p.H422R	EPB41L4B_ENST00000374557.4_Missense_Mutation_p.H422R	NM_019114.3	NP_061987.3	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	422						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GAACGTTGAATGTCTCCGGGA	0.448000													50	13					0	0	1	0	0
C3orf38	285237	broad.mit.edu	37	3	88205426	88205426	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:88205426C>T	ENST00000318887.3	+	3	941	c.631C>T	c.(631-633)Ctt>Ttt	p.L211F	C3orf38_ENST00000486971.1_3'UTR	NM_173824.3	NP_776185.2	Q5JPI3	CC038_HUMAN	chromosome 3 open reading frame 38	211					apoptosis					breast(1)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	12		Lung NSC(201;0.17)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		AGAAGAATTTCTTTTTCTCAG	0.428000													36	65					0	0	1	0	0
GRPR	2925	broad.mit.edu	37	X	16170693	16170693	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:16170693C>T	ENST00000380289.2	+	3	1478	c.1080C>T	c.(1078-1080)tcC>tcT	p.S360S		NM_005314.2	NP_005305.1	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	360					cell proliferation	integral to plasma membrane	bombesin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(3)|stomach(1)|upper_aerodigestive_tract(3)	25	Hepatocellular(33;0.183)					GCATGACCTCCCTCAAGAGTA	0.522000													62	26					0	0	1	0	0
ATP2A2	488	broad.mit.edu	37	12	110778514	110778514	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:110778514C>T	ENST00000395494.2	+	13	2294	c.1731C>T	c.(1729-1731)atC>atT	p.I577I	ATP2A2_ENST00000539276.2_Silent_p.I604I|ATP2A2_ENST00000308664.6_Silent_p.I604I			P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	604	Interacts with HAX1.				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(10)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|urinary_tract(1)	38						CTCCGAGAATCGAGGTGGCCT	0.527000													27	75					0	0	1	0	0
CAPNS1	826	broad.mit.edu	37	19	36634007	36634007	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:36634007C>T	ENST00000246533.3	+	6	1031	c.433C>T	c.(433-435)Cgc>Tgc	p.R145C	CAPNS1_ENST00000588815.1_Missense_Mutation_p.R145C|CAPNS1_ENST00000588780.1_Missense_Mutation_p.R145C|CAPNS1_ENST00000587718.1_Missense_Mutation_p.R145C|CAPNS1_ENST00000589146.1_Intron|CAPNS1_ENST00000590874.1_Missense_Mutation_p.R115C	NM_001003962.1|NM_001749.2	NP_001003962.1|NP_001740.1	P04632	CPNS1_HUMAN	calpain, small subunit 1	145	EF-hand 2.				positive regulation of cell proliferation	cytoplasm|plasma membrane	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			cervix(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	5	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			TGACACATGTCGCAGCATGGT	0.527000													62	75					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41149355	41149355	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:41149355C>T	ENST00000263413.3	-	17	2875	c.2611G>A	c.(2611-2613)Gaa>Aaa	p.E871K	C6_ENST00000337836.5_Missense_Mutation_p.E871K	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	871	C5b-binding domain.|Complement control factor I module 2.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding	p.E871K(1)		central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GAACATTTTTCCCAGTCATAG	0.418000													81	187					0	0	1	0	0
WDR4	10785	broad.mit.edu	37	21	44283566	44283566	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:44283566G>A	ENST00000398208.2	-	4	496	c.437C>T	c.(436-438)tCt>tTt	p.S146F	WDR4_ENST00000330317.2_Missense_Mutation_p.S146F|WDR4_ENST00000492742.1_5'UTR	NM_001260474.1|NM_001260475.1|NM_001260476.1|NM_018669.5	NP_001247403.1|NP_001247404.1|NP_001247405.1|NP_061139.2	P57081	WDR4_HUMAN	WD repeat domain 4	146					tRNA modification	cytoplasm|nucleoplasm	protein binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(3)|ovary(2)	11				Colorectal(79;0.0165)|Lung(125;0.0484)|STAD - Stomach adenocarcinoma(101;0.0624)|COAD - Colon adenocarcinoma(84;0.128)|LUSC - Lung squamous cell carcinoma(216;0.244)		TAACAGCATAGACAGGTGCCC	0.612000													36	54					0	0	1	0	0
LAMA1	284217	broad.mit.edu	37	18	7036045	7036045	+	Missense_Mutation	SNP	C	C	T	rs143022454	byFrequency	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:7036045C>T	ENST00000389658.3	-	13	1873	c.1780G>A	c.(1780-1782)Gat>Aat	p.D594N		NM_005559.3	NP_005550.2	P25391	LAMA1_HUMAN	laminin, alpha 1	594	Laminin IV type A 1.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			NS(4)|breast(7)|central_nervous_system(3)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(49)|liver(1)|lung(71)|ovary(9)|pancreas(3)|prostate(5)|skin(11)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(3)	205		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACCGGAATATCGTAGGACACC	0.443000													18	35					0	0	1	0	0
CDH7	1005	broad.mit.edu	37	18	63548003	63548003	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:63548003C>T	ENST00000397968.2	+	12	2657	c.2231C>T	c.(2230-2232)tCa>tTa	p.S744L	CDH7_ENST00000323011.3_Missense_Mutation_p.S744L	NM_004361.2	NP_004352.2	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2	744					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(43)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(2)	80		Esophageal squamous(42;0.129)				GTTGCTGAATCACTCAGCTCT	0.453000													28	74					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	17142113	17142113	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:17142113G>A	ENST00000377833.4	-	14	1721	c.1656C>T	c.(1654-1656)agC>agT	p.S552S		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	552	CUB 1.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CATGAGGGAGGCTGGAGCCAC	0.428000													20	37					0	0	1	0	0
UGT2B15	7366	broad.mit.edu	37	4	69512844	69512844	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:69512844C>T	ENST00000338206.5	-	6	1580	c.1571G>A	c.(1570-1572)gGa>gAa	p.G524E		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	524					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										CTTCTTCTTTCCTTTTTTGGC	0.393000													25	111					0	0	1	0	0
NUDT15	55270	broad.mit.edu	37	13	48612039	48612039	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:48612039G>A	ENST00000258662.2	+	1	337	c.158_splice	c.e1+1	p.G53_splice	SUCLA2_ENST00000543413.1_5'UTR	NM_018283.1	NP_060753.1	Q9NV35	NUD15_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 15	53	Nudix hydrolase.						hydrolase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(1)	7		all_cancers(8;3.75e-25)|all_epithelial(8;1.78e-13)|all_lung(13;2.85e-06)|Breast(56;0.000141)|all_hematologic(8;0.000219)|Lung NSC(96;0.000226)|Prostate(109;0.00132)|Acute lymphoblastic leukemia(8;0.0167)|Myeloproliferative disorder(33;0.039)|Hepatocellular(98;0.0556)|Lung SC(185;0.102)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(144;4.83e-07)		TCTGGAGTTCGGGTGAGCAGC	0.647000											OREG0022405	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	18					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41966269	41966269	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:41966269G>A	ENST00000298919.7	+	10	1296	c.908G>A	c.(907-909)cGa>cAa	p.R303Q	PDZRN4_ENST00000402685.2_Missense_Mutation_p.R563Q|PDZRN4_ENST00000539469.2_Missense_Mutation_p.R305Q			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	563	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding	p.R305Q(1)|p.R563Q(1)		breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				GAAAGCTTGCGAAATGATGAG	0.493000													14	33					0	0	1	0	0
AFF4	27125	broad.mit.edu	37	5	132269998	132269998	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:132269998G>A	ENST00000265343.5	-	3	1138	c.759C>T	c.(757-759)ccC>ccT	p.P253P	AFF4_ENST00000491831.1_5'UTR|AFF4_ENST00000378595.3_Silent_p.P253P	NM_014423.3	NP_055238.1	Q9UHB7	AFF4_HUMAN	AF4/FMR2 family, member 4	253	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity		SEPT8/AFF4(2)	breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(7)|lung(11)|ovary(3)|pancreas(1)|prostate(3)|skin(2)	43		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CATAGGCAGTGGGTTTCTGTA	0.512000													19	54					0	0	1	0	0
NAB1	4664	broad.mit.edu	37	2	191524716	191524716	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:191524716C>T	ENST00000337386.5	+	4	1275	c.814C>T	c.(814-816)Cat>Tat	p.H272Y	NAB1_ENST00000409581.1_Missense_Mutation_p.H272Y|NAB1_ENST00000357215.5_Missense_Mutation_p.H272Y|NAB1_ENST00000545490.1_Missense_Mutation_p.H42Y|NAB1_ENST00000484774.1_3'UTR|NAB1_ENST00000409641.1_Missense_Mutation_p.H272Y	NM_005966.3	NP_005957.2	Q13506	NAB1_HUMAN	NGFI-A binding protein 1 (EGR1 binding protein 1)	272	NCD2.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				kidney(2)|large_intestine(2)|lung(1)|prostate(1)|skin(1)	7			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0405)|all cancers(119;0.109)			TCTCACACTTCATGAGGTACA	0.413000													28	34					0	0	1	0	0
HTR2C	3358	broad.mit.edu	37	X	114082662	114082662	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:114082662C>T	ENST00000276198.1	+	5	1174	c.446C>T	c.(445-447)tCg>tTg	p.S149L	HTR2C_ENST00000371950.3_Missense_Mutation_p.S149L|HTR2C_ENST00000371951.1_Missense_Mutation_p.S149L	NM_000868.2	NP_000859.1	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	149					cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	TGCGCTATATCGCTGGATCGG	0.428000													48	13					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86286971	86286971	+	Silent	SNP	C	C	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:86286971C>A	ENST00000394518.2	+	36	8402	c.8307C>A	c.(8305-8307)gcC>gcA	p.A2769A	AKAP13_ENST00000361243.2_Silent_p.A2773A|AKAP13_ENST00000560579.1_3'UTR|AKAP13_ENST00000394510.2_Silent_p.A1014A	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	2769	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						CCACCTCTGCCTCTACCCGCC	0.522000													43	29					5.78141e-17	5.85055e-17	1	1	0
CFAP54	144535	broad.mit.edu	37	12	97137536	97137536	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:97137536G>A	ENST00000524981.3	+	21	2758	c.2758G>A	c.(2758-2760)Gaa>Aaa	p.E920K				Q6ZTY8	CL063_HUMAN		894										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						GGAAGGAAATGAATTTATTTC	0.343000													7	8					0	0	1	0	0
GALNTL6	442117	broad.mit.edu	37	4	173873278	173873278	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:173873278G>A	ENST00000506823.1	+	10	1897	c.1240G>A	c.(1240-1242)Gac>Aac	p.D414N	GALNTL6_ENST00000508122.1_Missense_Mutation_p.D397N	NM_001034845.2	NP_001030017.2	Q49A17	GLTL6_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6	414						Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(2)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	45						CTCCACGGGGGACATCTCTGC	0.567000													13	68					0	0	1	0	0
RAB5B	5869	broad.mit.edu	37	12	56385228	56385228	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:56385228C>T	ENST00000360299.5	+	5	744	c.523C>T	c.(523-525)Ctg>Ttg	p.L175L	RAB5B_ENST00000553116.1_Silent_p.L175L|RAB5B_ENST00000448789.2_Silent_p.L134L	NM_002868.3	NP_002859.1	P61020	RAB5B_HUMAN	RAB5B, member RAS oncogene family	175					protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|membrane fraction|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity			endometrium(1)|large_intestine(1)|liver(2)|lung(4)|upper_aerodigestive_tract(1)	9			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.235)			TGATCTCTTCCTGGCAATAGG	0.458000													6	38					0	0	1	0	0
FYB	2533	broad.mit.edu	37	5	39153643	39153643	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:39153643G>A	ENST00000351578.6	-	3	1389	c.1199C>T	c.(1198-1200)cCg>cTg	p.P400L	FYB_ENST00000512982.1_Missense_Mutation_p.P400L|FYB_ENST00000515010.1_Missense_Mutation_p.P400L|FYB_ENST00000540520.1_Missense_Mutation_p.P410L|FYB_ENST00000505428.1_Missense_Mutation_p.P400L	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	400	Interaction with SKAP1.				cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			TTGGCTGGCCGGATGGGATGG	0.493000													42	128					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78925636	78925636	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:78925636G>A	ENST00000545128.1	+	29	4210	c.3672G>A	c.(3670-3672)agG>agA	p.R1224R		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	870					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						CTTCCGTAAGGAGTGGGAGCT	0.557000													7	5					0	0	1	0	0
SULT2A1	6822	broad.mit.edu	37	19	48386958	48386958	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:48386958C>T	ENST00000222002.3	-	2	360	c.221G>A	c.(220-222)cGa>cAa	p.R74Q		NM_003167.3	NP_003158.2	Q06520	ST2A1_HUMAN	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1	74					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		CCAGGGTGATCGCTCCCAGAT	0.517000													12	15					0	0	1	0	0
UNC5D	137970	broad.mit.edu	37	8	35579897	35579897	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:35579897C>T	ENST00000453357.2	+	9	1328	c.1272C>T	c.(1270-1272)ttC>ttT	p.F424F	UNC5D_ENST00000420357.1_Silent_p.F362F|UNC5D_ENST00000416672.1_Silent_p.F434F|UNC5D_ENST00000287272.2_Intron|UNC5D_ENST00000404895.2_Silent_p.F429F			Q6UXZ4	UNC5D_HUMAN	unc-5 homolog D (C. elegans)	429					apoptosis|axon guidance	integral to membrane	receptor activity			NS(2)|breast(7)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(14)|lung(56)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(6)|urinary_tract(2)	112				READ - Rectum adenocarcinoma(1;1.31e-05)|Colorectal(1;0.000723)		CCTTCAACTTCAAAACAGTCC	0.552000													49	79					0	0	1	0	0
EFHB	151651	broad.mit.edu	37	3	19926050	19926050	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:19926050G>A	ENST00000295824.9	-	11	2152	c.1991C>T	c.(1990-1992)aCt>aTt	p.T664I	EFHB_ENST00000344838.4_Missense_Mutation_p.T534I	NM_144715.3	NP_653316.3	Q8N7U6	EFHB_HUMAN	EF-hand domain family, member B	664					signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(2)|endometrium(4)|kidney(1)|lung(17)|prostate(1)|urinary_tract(1)	26						TATGAGGAGAGTTTGTTCAGG	0.368000													17	48					0	0	1	0	0
CXCL5	6374	broad.mit.edu	37	4	74863790	74863790	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:74863790C>T	ENST00000296027.4	-	3	462	c.265G>A	c.(265-267)Gaa>Aaa	p.E89K		NM_002994.3	NP_002985.1	P42830	CXCL5_HUMAN	chemokine (C-X-C motif) ligand 5	89					cell-cell signaling|chemotaxis|immune response|positive regulation of cell proliferation|signal transduction	extracellular space	chemokine activity	p.E89K(1)		endometrium(3)|large_intestine(2)|lung(3)|urinary_tract(1)	9	Breast(15;0.00136)		all cancers(17;0.00273)|Lung(101;0.196)			AGACAAATTTCCTTCCCGTTC	0.423000													56	29					0	0	1	0	0
YTHDC2	64848	broad.mit.edu	37	5	112926865	112926865	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:112926865G>A	ENST00000161863.4	+	27	4166	c.3953G>A	c.(3952-3954)cGg>cAg	p.R1318Q		NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1318	YTH.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		AGTAATGAACGGAAGCTAAAT	0.398000													37	76					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6710854	6710854	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:6710854G>A	ENST00000245907.6	-	13	1574	c.1482C>T	c.(1480-1482)atC>atT	p.I494I		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	494					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CCTTGTTCATGATCTGGGGGG	0.657000													15	27					0	0	1	0	0
MTHFR	4524	broad.mit.edu	37	1	11856429	11856429	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:11856429C>T	ENST00000376592.1	-	4	742	c.614G>A	c.(613-615)gGg>gAg	p.G205E	MTHFR_ENST00000376583.3_Missense_Mutation_p.G246E|MTHFR_ENST00000376585.1_Missense_Mutation_p.G246E|MTHFR_ENST00000376590.3_Missense_Mutation_p.G205E			P42898	MTHR_HUMAN	methylenetetrahydrofolate reductase (NAD(P)H)	205					blood circulation|folic acid metabolic process	cytosol	methylenetetrahydrofolate reductase (NADPH) activity|protein binding			NS(4)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(6)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	33	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)	Benazepril(DB00542)|Cyanocobalamin(DB00115)|Folic Acid(DB00158)|L-Methionine(DB00134)|Menadione(DB00170)|Methotrexate(DB00563)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|Raltitrexed(DB00293)|Riboflavin(DB00140)|S-Adenosylmethionine(DB00118)|Tetrahydrofolic acid(DB00116)	CTCAAAGCTCCCTGCTTCGGG	0.562000													182	128					0	0	1	0	0
RYR1	6261	broad.mit.edu	37	19	38935283	38935283	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:38935283G>A	ENST00000355481.4	+	7	728	c.597G>A	c.(595-597)tgG>tgA	p.W199*	RYR1_ENST00000359596.3_Nonsense_Mutation_p.W199*|RYR1_ENST00000360985.3_Nonsense_Mutation_p.W199*	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	199	MIR 2.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	AGACACTATGGAACATGAACC	0.597000													11	9					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110523106	110523106	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:110523106C>T	ENST00000378402.5	+	71	11600	c.11496C>T	c.(11494-11496)ttC>ttT	p.F3832F		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3832					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			AAGTTTACTTCACTGGCACCA	0.438000										HNSCC(38;0.096)			60	73					0	0	1	0	0
SLITRK6	84189	broad.mit.edu	37	13	86368439	86368439	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:86368439C>T	ENST00000400286.2	-	2	2803	c.2205G>A	c.(2203-2205)atG>atA	p.M735I		NM_032229.2	NP_115605.2	Q9H5Y7	SLIK6_HUMAN	SLIT and NTRK-like family, member 6	735						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(18)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		TTTTGTATTTCATATTTGACC	0.373000													94	123					0	0	1	0	0
IL7R	3575	broad.mit.edu	37	5	35873655	35873655	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:35873655A>T	ENST00000303115.3	+	5	740	c.611A>T	c.(610-612)aAa>aTa	p.K204I	IL7R_ENST00000506850.1_Missense_Mutation_p.K204I|IL7R_ENST00000343305.4_Missense_Mutation_p.K204I	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	204	Fibronectin type-III.				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			TATGAGATTAAAGTTCGATCC	0.418000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						16	47					0	0	1	0	0
TRIM58	25893	broad.mit.edu	37	1	248028153	248028153	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:248028153G>A	ENST00000366481.3	+	3	711	c.663G>A	c.(661-663)cgG>cgA	p.R221R		NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	221						intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GCAAGAGCCGGCTGGTCCAGC	0.692000													7	16					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103322349	103322349	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:103322349G>A	ENST00000233969.2	+	11	2164	c.2022G>A	c.(2020-2022)acG>acA	p.T674T		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	674						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						CTAAAAATACGAAGCTTCCAG	0.303000													14	25					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126173630	126173630	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:126173630G>A	ENST00000339582.2	-	9	2614	c.1806C>T	c.(1804-1806)atC>atT	p.I602I	GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000358373.3_Silent_p.I602I|GRM8_ENST00000444921.2_Silent_p.I602I			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	602					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CAAAGGTCACGATCACAAAGG	0.483000										HNSCC(24;0.065)			10	26					0	0	1	0	0
OR10G9	219870	broad.mit.edu	37	11	123894476	123894476	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:123894476C>T	ENST00000375024.1	+	1	757	c.757C>T	c.(757-759)Ccc>Tcc	p.P253S		NM_001001953.1	NP_001001953.1	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G, member 9	253					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(33)|prostate(2)|skin(4)|stomach(8)|urinary_tract(1)	61		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		CTTTTTTGTTCCCTGTGTTTT	0.537000													36	68					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121358855	121358855	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:121358855G>A	ENST00000260197.7	+	4	772	c.643G>A	c.(643-645)Gcc>Acc	p.A215T	SORL1_ENST00000532451.1_3'UTR	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	215					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		ACACAGTAAGGCCTCCAACCT	0.522000													69	97					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196729151	196729151	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:196729151C>T	ENST00000312428.6	-	41	7328	c.7228G>A	c.(7228-7230)Gaa>Aaa	p.E2410K		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2410	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CTGACATCTTCCAGAAAAGAC	0.393000													18	39					0	0	1	0	0
OR8H3	390152	broad.mit.edu	37	11	55890636	55890636	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:55890636G>A	ENST00000313472.3	+	1	788	c.788G>A	c.(787-789)aGa>aAa	p.R263K		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					TTAAAGCCAAGAAAGTCTTAT	0.388000													21	42					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32029313	32029313	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:32029313C>T	ENST00000375244.3	-	21	7554	c.7353G>A	c.(7351-7353)cgG>cgA	p.R2451R	TNXB_ENST00000375247.2_Silent_p.R2451R			P22105	TENX_HUMAN	tenascin XB	2511					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CCACCTGGGGCCGCCCGTCCC	0.667000													30	63					0	0	1	0	0
MARCH10	162333	broad.mit.edu	37	17	60802406	60802406	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:60802406C>T	ENST00000544856.2	-	8	2372	c.1994G>A	c.(1993-1995)gGg>gAg	p.G665E	MARCH10_ENST00000311269.5_Missense_Mutation_p.G666E|MARCH10_ENST00000583600.1_Missense_Mutation_p.G704E|RP11-156L14.1_ENST00000584597.1_RNA|RP11-156L14.1_ENST00000579201.1_RNA|RP11-156L14.1_ENST00000577270.1_RNA|MARCH10_ENST00000456609.2_Missense_Mutation_p.G666E|RP11-156L14.1_ENST00000582564.1_RNA			Q8NA82	MARHA_HUMAN	membrane-associated ring finger (C3HC4) 10, E3 ubiquitin protein ligase	666							ligase activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(11)|liver(1)|lung(15)	38						TGGGGAACCCCCGGCTATCTG	0.547000													42	53					0	0	1	0	0
ASIC2	40	broad.mit.edu	37	17	31351000	31351000	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:31351000G>A	ENST00000225823.2	-	6	2100	c.1228C>T	c.(1228-1230)Ctc>Ttc	p.L410F	ASIC2_ENST00000448983.1_5'UTR|ASIC2_ENST00000359872.6_Missense_Mutation_p.L359F	NM_183377.1	NP_899233.1	Q16515	ACCN1_HUMAN	acid-sensing (proton-gated) ion channel 2	359					central nervous system development|peripheral nervous system development|synaptic transmission	integral to plasma membrane	ligand-gated sodium channel activity|protein binding									Amiloride(DB00594)	GTCCTGCAGAGACAGTAATTG	0.517000													41	55					0	0	1	0	0
ZNF485	220992	broad.mit.edu	37	10	44112749	44112749	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:44112749C>T	ENST00000361807.3	+	5	1452	c.1258C>T	c.(1258-1260)Ccc>Tcc	p.P420S	ZNF485_ENST00000374435.3_Missense_Mutation_p.P420S|ZNF485_ENST00000374437.2_Missense_Mutation_p.P329S	NM_145312.3	NP_660355.2	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	420					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	16						GAAAGCTTTTCCCCGAAGTTC	0.398000													17	5					0	0	1	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3139413	3139413	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:3139413G>A	ENST00000252463.2	-	5	1944	c.1857C>T	c.(1855-1857)agC>agT	p.S619S	ZSCAN10_ENST00000538082.2_Silent_p.S537S|ZSCAN10_ENST00000575108.1_Silent_p.S280S	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	619					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						CCAGGTTGGAGCTATTGCGGA	0.711000													32	55					0	0	1	0	0
OR5H2	79310	broad.mit.edu	37	3	98002320	98002320	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:98002320C>T	ENST00000355273.2	+	1	589	c.589C>T	c.(589-591)Cct>Tct	p.P197S	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005482.1	NP_001005482.1	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H, member 2	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						CTGTACTGACCCTTCTATTAA	0.303000													13	21					0	0	1	0	0
S100A7L2	645922	broad.mit.edu	37	1	153410686	153410686	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:153410686G>A	ENST00000368725.2	-	2	152	c.153C>T	c.(151-153)ttC>ttT	p.F51F		NM_001045479.1	NP_001038944.2			S100 calcium binding protein A7-like 2											NS(1)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(1)	8	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGAAGTTGGGGAAGTTCTCCT	0.507000													38	28					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100086437	100086437	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:100086437G>A	ENST00000423930.1	+	4	1252	c.1093G>A	c.(1093-1095)Gag>Aag	p.E365K	NYAP1_ENST00000300179.2_Missense_Mutation_p.E365K|NYAP1_ENST00000454988.1_Missense_Mutation_p.E308K			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	365	Pro-rich.																CCACTCCAAGGAGCCAGCCGG	0.687000													25	51					0	0	1	0	0
KCNK10	54207	broad.mit.edu	37	14	88729552	88729552	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:88729552C>T	ENST00000340700.5	-	2	832	c.381G>A	c.(379-381)ttG>ttA	p.L127L	KCNK10_ENST00000319231.5_Silent_p.L132L|KCNK10_ENST00000312350.5_Silent_p.L132L	NM_021161.4	NP_066984.1	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	127					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						TCACCTGGATCAACGTCTCCA	0.547000													21	5					0	0	1	0	0
VPS13D	55187	broad.mit.edu	37	1	12337081	12337081	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:12337081T>A	ENST00000358136.3	+	19	3566	c.3436T>A	c.(3436-3438)Ttt>Att	p.F1146I	VPS13D_ENST00000356315.4_Missense_Mutation_p.F1146I	NM_015378.2	NP_056193.2	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13 homolog D (S. cerevisiae)	1146					protein localization					NS(1)|breast(6)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(28)|lung(44)|ovary(5)|pancreas(1)|prostate(8)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(4)	130	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		AATGACTGATTTTGAAAGAAG	0.383000													40	30					0	0	1	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147040593	147040593	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:147040593C>T	ENST00000265272.5	-	3	1012	c.545G>A	c.(544-546)gGg>gAg	p.G182E	JAKMIP2_ENST00000333010.6_Missense_Mutation_p.G140E|JAKMIP2_ENST00000507386.1_Missense_Mutation_p.G182E	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	182						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGAAGGTCCCCAGCCTTGAT	0.517000													66	94					0	0	1	0	0
RNF123	63891	broad.mit.edu	37	3	49738092	49738092	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:49738092C>T	ENST00000327697.6	+	15	1371	c.1227C>T	c.(1225-1227)atC>atT	p.I409I	RNF123_ENST00000432042.1_Silent_p.I263I	NM_022064.3	NP_071347.2	Q5XPI4	RN123_HUMAN	ring finger protein 123	409						cytoplasm	ligase activity|protein binding|zinc ion binding			NS(1)|breast(4)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;4.71e-05)|Kidney(197;0.00227)|KIRC - Kidney renal clear cell carcinoma(197;0.00255)		GGCTCACTATCGCCATCCTGA	0.607000													55	85					0	0	1	0	0
EMB	133418	broad.mit.edu	37	5	49698148	49698148	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:49698148C>T	ENST00000303221.5	-	7	1098	c.883G>A	c.(883-885)Ggg>Agg	p.G295R	EMB_ENST00000508934.1_Missense_Mutation_p.G241R|EMB_ENST00000514111.1_Missense_Mutation_p.G245R	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	295						integral to membrane				breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				AATTCTTTCCCCTCATCTGTG	0.308000													5	27					0	0	1	0	0
DDX10	1662	broad.mit.edu	37	11	108546451	108546451	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:108546451C>T	ENST00000526794.1	+	3	408	c.376C>T	c.(376-378)Cca>Tca	p.P126S	DDX10_ENST00000322536.3_Missense_Mutation_p.P126S			Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	126	Helicase ATP-binding.						ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		TTTTCTTGTTCCAGTAAGTAC	0.398000			T	NUP98	AML*								28	53					0	0	1	0	0
CYP17A1	1586	broad.mit.edu	37	10	104592929	104592929	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:104592929C>T	ENST00000369887.3	-	5	961	c.790G>A	c.(790-792)Gac>Aac	p.D264N	CYP17A1-AS1_ENST00000369884.4_RNA	NM_000102.3	NP_000093.1	P05093	CP17A_HUMAN	cytochrome P450, family 17, subfamily A, polypeptide 1	264					androgen biosynthetic process|glucocorticoid biosynthetic process|sex differentiation|xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|oxygen binding|steroid 17-alpha-monooxygenase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)	NADH(DB00157)|Progesterone(DB00396)	ATCAGTGTGTCCAGCATGTTG	0.493000													34	19					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179515513	179515513	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179515513G>A	ENST00000589042.1	-	209	39898	c.39674C>T	c.(39673-39675)cCt>cTt	p.P13225L	TTN_ENST00000342992.6_Missense_Mutation_p.P10791L|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P11718L|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	11580	Ig-like 88.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCTGGAACAGGAACAGCTGG	0.403000													3	9					0	0	1	0	0
BRMS1	25855	broad.mit.edu	37	11	66108723	66108723	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:66108723G>A	ENST00000359957.3	-	4	472	c.312C>T	c.(310-312)ccC>ccT	p.P104P	BRMS1_ENST00000425825.2_Silent_p.P104P	NM_015399.3	NP_056214.1	Q9HCU9	BRMS1_HUMAN	breast cancer metastasis suppressor 1	104					apoptosis|negative regulation of anti-apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of anoikis|positive regulation of protein deacetylation|transcription, DNA-dependent	cytoplasm|nucleus	NF-kappaB binding			large_intestine(1)|liver(1)|lung(1)|prostate(1)|skin(1)	5						GCCCCCCAAGGGGCTCCGTGT	0.617000													25	43					0	0	1	0	0
SORL1	6653	broad.mit.edu	37	11	121495971	121495971	+	Missense_Mutation	SNP	G	G	A	rs144806633		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:121495971G>A	ENST00000260197.7	+	46	6478	c.6349G>A	c.(6349-6351)Gat>Aat	p.D2117N	SORL1_ENST00000532694.1_Missense_Mutation_p.D963N|SORL1_ENST00000534286.1_Missense_Mutation_p.D1027N|SORL1_ENST00000527934.1_Missense_Mutation_p.D732N|SORL1_ENST00000525532.1_Missense_Mutation_p.D1061N	NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	2117	Fibronectin type-III 6.				cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		CCTGCTGTACGATGAGCTGGG	0.478000													35	36					0	0	1	0	0
SEMG1	6406	broad.mit.edu	37	20	43837308	43837308	+	Missense_Mutation	SNP	G	G	A	rs137914795	byFrequency	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:43837308G>A	ENST00000372781.3	+	2	1427	c.1370G>A	c.(1369-1371)cGa>cAa	p.R457Q	SEMG1_ENST00000244069.6_Missense_Mutation_p.R397Q	NM_003007.3	NP_002998.1			semenogelin I											cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|prostate(1)|skin(6)|stomach(2)|urinary_tract(1)	32		Myeloproliferative disorder(115;0.0122)				AACAACGACCGAAACCCATTA	0.393000													47	106					0	0	1	0	0
LOC100128164	100128164	broad.mit.edu	37	3	169664630	169664630	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:169664630C>T	ENST00000483289.2	-	0	2664				RP11-379K17.4_ENST00000487580.1_RNA	NR_027622.1																						AAAACAACTTCCAACGTGCTG	0.522000													4	5					0	0	1	0	0
HSPG2	3339	broad.mit.edu	37	1	22206686	22206686	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:22206686G>A	ENST00000374695.3	-	17	2336	c.2257C>T	c.(2257-2259)Cct>Tct	p.P753S		NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	753	Laminin EGF-like 1; second part.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	GGCCCACCAGGCACCCGAGTG	0.597000													9	59					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47480802	47480802	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:47480802G>A	ENST00000285039.7	-	13	1848	c.1549C>T	c.(1549-1551)Ccc>Tcc	p.P517S		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	517	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		GTTCCTTTGGGGACCTGCAGA	0.572000													22	40					0	0	1	0	0
NTRK3	4916	broad.mit.edu	37	15	88423503	88423503	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:88423503C>T	ENST00000394480.1	-	18	2611	c.2290G>A	c.(2290-2292)Gag>Aag	p.E764K	NTRK3_ENST00000355254.2_Missense_Mutation_p.E764K|NTRK3_ENST00000360948.2_Missense_Mutation_p.E778K|NTRK3_ENST00000357724.2_Missense_Mutation_p.E770K|NTRK3_ENST00000557856.1_Missense_Mutation_p.E756K	NM_001243101.1|NM_002530.3	NP_001230030.1|NP_002521.2	Q16288	NTRK3_HUMAN	neurotrophic tyrosine kinase, receptor, type 3	778	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity		ETV6/NTRK3(238)	breast(3)|central_nervous_system(3)|endometrium(6)|kidney(1)|large_intestine(22)|lung(63)|ovary(6)|pancreas(3)|prostate(1)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)	119			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTTTTTACCTCCGTGTTTGAG	0.502000			T	ETV6	"""congenital fibrosarcoma, Secretory breast """					TSP Lung(13;0.10)			21	69					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93803566	93803566	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:93803566G>A	ENST00000315765.9	+	6	1098	c.1090G>A	c.(1090-1092)Gat>Aat	p.D364N		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	364	Plastocyanin-like 2.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				ATACAATGTTGATAACTGCAA	0.413000													5	8					0	0	1	0	0
LTA	4049	broad.mit.edu	37	6	31540711	31540711	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:31540711C>T	ENST00000454783.1	+	3	364	c.106C>T	c.(106-108)Cct>Tct	p.P36S	LTA_ENST00000418386.2_Missense_Mutation_p.P36S	NM_001159740.2	NP_001153212.1	P01374	TNFB_HUMAN	lymphotoxin alpha	36					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding			endometrium(2)|kidney(2)|lung(4)|upper_aerodigestive_tract(1)	9					Etanercept(DB00005)	CTAGGGGCTCCCTGGTGTTGG	0.632000													36	25					0	0	1	0	0
PILRA	29992	broad.mit.edu	37	7	99971862	99971862	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:99971862C>T	ENST00000198536.2	+	2	472	c.260C>T	c.(259-261)cCt>cTt	p.P87L	PILRA_ENST00000350573.2_Missense_Mutation_p.P87L|PILRA_ENST00000394000.2_Missense_Mutation_p.P87L|PILRA_ENST00000474013.1_3'UTR|PILRA_ENST00000453419.1_Missense_Mutation_p.P87L	NM_013439.2	NP_038467.2	Q9UKJ1	PILRA_HUMAN	paired immunoglobin-like type 2 receptor alpha	87	Ig-like V-type.				interspecies interaction between organisms	extracellular region|integral to membrane|plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	15	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ACAAGGCCGCCTTCCATTCAC	0.552000													45	86					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143771847	143771847	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:143771847G>A	ENST00000408898.2	+	1	573	c.535G>A	c.(535-537)Gaa>Aaa	p.E179K		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	179					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					CTTTTTCTGTGAAATTATGGC	0.463000													60	104					0	0	1	0	0
BLCAP	10904	broad.mit.edu	37	20	36147523	36147523	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:36147523G>A	ENST00000414542.2	-	3	501	c.54C>T	c.(52-54)aaC>aaT	p.N18N	BLCAP_ENST00000397134.1_Silent_p.N18N|BLCAP_ENST00000397135.1_Silent_p.N18N|BLCAP_ENST00000467603.1_Intron|BLCAP_ENST00000373537.2_Silent_p.N18N|BLCAP_ENST00000397131.1_Silent_p.N18N|BLCAP_ENST00000397137.1_Silent_p.N18N	NM_001167820.1|NM_001167823.1	NP_001161292.1|NP_001161295.1	P62952	BLCAP_HUMAN	bladder cancer associated protein	18					apoptosis|cell cycle	integral to membrane				breast(1)|large_intestine(1)|lung(2)|stomach(1)	5		Myeloproliferative disorder(115;0.00878)				ACAGGGCGGGGTTGAGGGGCT	0.612000													9	15					0	0	1	0	0
ZNF727	442319	broad.mit.edu	37	7	63538735	63538735	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:63538735C>T	ENST00000550760.3	+	4	1487	c.1308C>T	c.(1306-1308)ttC>ttT	p.F436F		NM_001159522.1	NP_001152994.1	A8MUV8	ZN727_HUMAN	zinc finger protein 727	436					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|skin(1)|stomach(1)|urinary_tract(1)	8						TTAAGTGGTTCCCAGACCTGA	0.393000													4	9					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801664	185801664	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:185801664G>A	ENST00000302277.6	+	4	2135	c.1541G>A	c.(1540-1542)gGa>gAa	p.G514E		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	514						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						TATGAAATTGGAAGTAGCAAA	0.398000													33	56					0	0	1	0	0
GABRR3	200959	broad.mit.edu	37	3	97753802	97753802	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:97753802G>A	ENST00000472788.1	-	0	31					NM_001105580.2	NP_001099050.1	A8MPY1	GBRR3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 3						gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			large_intestine(2)|lung(1)	3						AGATGTAGGTGAAGGAGACTA	0.423000													9	18					0	0	1	0	0
SLC9A4	389015	broad.mit.edu	37	2	103121827	103121827	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:103121827G>A	ENST00000295269.4	+	4	1552	c.1095G>A	c.(1093-1095)ttG>ttA	p.L365L		NM_001011552.3	NP_001011552.2	Q6AI14	SL9A4_HUMAN	solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4	365					regulation of pH	apical plasma membrane|basolateral plasma membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	43						GCGAGACCTTGATCTTCATCT	0.493000													19	44					0	0	1	0	0
GABPA	2551	broad.mit.edu	37	21	27141393	27141393	+	Silent	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:27141393T>A	ENST00000354828.3	+	10	1742	c.1215T>A	c.(1213-1215)acT>acA	p.T405T	GABPA_ENST00000400075.3_Silent_p.T405T	NM_001197297.1	NP_001184226.1	Q06546	GABPA_HUMAN	GA binding protein transcription factor, alpha subunit 60kDa	405					positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	24						ACTTGAAGACTCTTATTGGAT	0.393000													69	104					0	0	1	0	0
NPAP1	23742	broad.mit.edu	37	15	24921274	24921274	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:24921274C>T	ENST00000329468.2	+	1	734	c.260C>T	c.(259-261)gCt>gTt	p.A87V		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		GTCCTGCCGGCTGTGGGTTGG	0.682000													7	26					0	0	1	0	0
PLXNA3	55558	broad.mit.edu	37	X	153691743	153691743	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:153691743G>T	ENST00000369682.3	+	5	1502	c.1327G>T	c.(1327-1329)Gat>Tat	p.D443Y		NM_017514.3	NP_059984.2	P51805	PLXA3_HUMAN	plexin A3	443	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	transmembrane receptor activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(26)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	48	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGTGCGGGTCGATGGCTTCCA	0.612000													89	28					3.85665e-30	3.91664e-30	1	1	0
CNOT4	4850	broad.mit.edu	37	7	135047787	135047787	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:135047787G>A	ENST00000541284.1	-	12	2322	c.1992C>T	c.(1990-1992)atC>atT	p.I664I	CNOT4_ENST00000423368.2_Silent_p.I593I|CNOT4_ENST00000473470.1_5'UTR|CNOT4_ENST00000361528.4_Silent_p.I590I|CNOT4_ENST00000451834.1_Silent_p.I661I	NM_001190849.1|NM_001190850.1	NP_001177778.1|NP_001177779.1	O95628	CNOT4_HUMAN	CCR4-NOT transcription complex, subunit 4	330					nuclear-transcribed mRNA poly(A) tail shortening|protein autoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	nucleotide binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			autonomic_ganglia(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)	22						TGTGCAGCGGGATCTGTGTGC	0.612000													76	103					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179436060	179436060	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179436060G>A	ENST00000589042.1	-	326	75023	c.74799C>T	c.(74797-74799)atC>atT	p.I24933I	TTN_ENST00000342992.6_Silent_p.I22365I|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.I23292I|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.I15868I|TTN_ENST00000342175.6_Silent_p.I16060I|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Silent_p.I15993I|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	23292	Fibronectin type-III 81.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCCATCACTGATTGGCTCAT	0.453000													24	40					0	0	1	0	0
TACC2	10579	broad.mit.edu	37	10	123892199	123892199	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:123892199C>T	ENST00000369005.1	+	6	5989	c.5649C>T	c.(5647-5649)tcC>tcT	p.S1883S	TACC2_ENST00000515273.1_Silent_p.S1932S|TACC2_ENST00000493951.1_Intron|TACC2_ENST00000334433.3_Silent_p.S1883S|TACC2_ENST00000515603.1_Silent_p.S1883S|TACC2_ENST00000453444.2_Silent_p.S1932S|TACC2_ENST00000369000.1_5'UTR|TACC2_ENST00000369001.1_5'UTR|TACC2_ENST00000358010.1_Silent_p.S74S|TACC2_ENST00000513429.1_Silent_p.S74S	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	1883						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CTGCCTCTTCCTACCACGGTG	0.582000													17	34					0	0	1	0	0
NAMPT	10135	broad.mit.edu	37	7	105893480	105893480	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:105893480G>A	ENST00000222553.3	-	10	1655	c.1348C>T	c.(1348-1350)Ctt>Ttt	p.L450F		NM_005746.2	NP_005737.1	P43490	NAMPT_HUMAN	nicotinamide phosphoribosyltransferase	450					cell-cell signaling|NAD biosynthetic process|nicotinamide metabolic process|positive regulation of cell proliferation|positive regulation of nitric-oxide synthase biosynthetic process|signal transduction|water-soluble vitamin metabolic process	cytosol	cytokine activity|nicotinamide phosphoribosyltransferase activity|nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	14						TATTCCTCAAGGTCTCCTTTT	0.398000													26	43					0	0	1	0	0
SFRP4	6424	broad.mit.edu	37	7	37954009	37954009	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:37954009C>T	ENST00000436072.2	-	2	869	c.492G>A	c.(490-492)agG>agA	p.R164R	EPDR1_ENST00000476620.1_Intron	NM_003014.3	NP_003005.2	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related protein 4	164					brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						CATCAAGAGGCCTTTCCTGTA	0.478000													20	29					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103671	53103671	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:53103671C>T	ENST00000408890.4	+	1	323	c.307C>T	c.(307-309)Ccc>Tcc	p.P103S		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	103										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CCCTGCCCTTCCCGGGGAGAC	0.726000													18	25					0	0	1	0	0
C7	730	broad.mit.edu	37	5	40934527	40934527	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:40934527C>T	ENST00000313164.9	+	4	598	c.239C>T	c.(238-240)cCa>cTa	p.P80L		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	80	TSP type-1 1.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				AGAGGATGTCCAACAGAGGAG	0.468000													34	97					0	0	1	0	0
SULF1	23213	broad.mit.edu	37	8	70476323	70476323	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:70476323G>A	ENST00000260128.4	+	5	830	c.113G>A	c.(112-114)cGa>cAa	p.R38Q	SULF1_ENST00000458141.2_Missense_Mutation_p.R38Q|SULF1_ENST00000402687.4_Missense_Mutation_p.R38Q|SULF1_ENST00000419716.3_Missense_Mutation_p.R38Q	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	38					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			CAGCAGGAACGAAAAAACATC	0.493000													28	47					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86261364	86261364	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:86261364T>A	ENST00000394518.2	+	22	6070	c.5975T>A	c.(5974-5976)gTg>gAg	p.V1992E	AKAP13_ENST00000361243.2_Missense_Mutation_p.V1996E|AKAP13_ENST00000560579.1_3'UTR|AKAP13_ENST00000394510.2_Missense_Mutation_p.V237E	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1992	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						AAGAAAGATGTGGTCAAACGG	0.383000													10	45					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142658496	142658496	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:142658496G>A	ENST00000355265.2	-	3	648	c.174C>T	c.(172-174)ctC>ctT	p.L58L	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	58					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					AAAAACAAAGGAGCAGGCCCA	0.582000													21	29					0	0	1	0	0
AHNAK	79026	broad.mit.edu	37	11	62286124	62286124	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:62286124G>A	ENST00000378024.4	-	5	16039	c.15765C>T	c.(15763-15765)gtC>gtT	p.V5255V	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	5255					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				GCTGGGCATGGACCTCGGCTC	0.522000													39	82					0	0	1	0	0
TNFRSF4	7293	broad.mit.edu	37	1	1147204	1147204	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:1147204C>T	ENST00000379236.3	-	6	647	c.643G>A	c.(643-645)Gtt>Att	p.V215I		NM_003327.3	NP_003318.1	P43489	TNR4_HUMAN	tumor necrosis factor receptor superfamily, member 4	215					immune response|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of immunoglobulin secretion|T cell proliferation	integral to plasma membrane	tumor necrosis factor receptor activity			large_intestine(1)|lung(2)|urinary_tract(1)	4	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.73e-36)|OV - Ovarian serous cystadenocarcinoma(86;1.01e-21)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.0025)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		ATGGCGGCAACCGCACGGCCT	0.736000													3	0					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	69020458	69020458	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:69020458G>A	ENST00000288368.4	+	24	3107	c.2830G>A	c.(2830-2832)Gaa>Aaa	p.E944K		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	944					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						CAATGTGATGGAAGTTTCTTA	0.418000													17	30					0	0	1	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52002861	52002861	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:52002861C>T	ENST00000291707.3	-	3	973	c.918G>A	c.(916-918)acG>acA	p.T306T	SIGLEC12_ENST00000598614.1_Silent_p.T188T	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	306	Ig-like C2-type 1.				cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		TCCAGGTGATCGTGGGGGGCG	0.667000													28	35					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56202405	56202405	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:56202405G>A	ENST00000361673.3	-	5	5227	c.5014C>T	c.(5014-5016)Cca>Tca	p.P1672S		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1672							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						TTTTGACATGGATCCTGCAGT	0.532000													29	62					0	0	1	0	0
MIP	4284	broad.mit.edu	37	12	56848294	56848294	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:56848294G>T	ENST00000257979.4	-	1	132	c.104C>A	c.(103-105)gCt>gAt	p.A35D	MIP_ENST00000555551.1_Intron	NM_012064.3	NP_036196.1	P30301	MIP_HUMAN	major intrinsic protein of lens fiber	35					response to stimulus|visual perception	gap junction|integral to plasma membrane	structural constituent of eye lens			kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	16						GGGTCCAGGAGCCCAGCGCAG	0.577000													16	67					6.72482e-11	6.78121e-11	1	1	0
DSCAML1	57453	broad.mit.edu	37	11	117391965	117391965	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:117391965C>T	ENST00000321322.6	-	6	1274	c.1273G>A	c.(1273-1275)Ggg>Agg	p.G425R	DSCAML1_ENST00000527706.1_Missense_Mutation_p.G155R	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	365	Ig-like C2-type 5.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TTGCTGAGCCCGCGGATGGAG	0.647000													60	94					0	0	1	0	0
RAP1GDS1	5910	broad.mit.edu	37	4	99355100	99355100	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:99355100C>T	ENST00000408927.3	+	13	1567	c.1454C>T	c.(1453-1455)aCc>aTc	p.T485I	RAP1GDS1_ENST00000339360.5_Missense_Mutation_p.T486I|RAP1GDS1_ENST00000408900.3_Missense_Mutation_p.T436I|RAP1GDS1_ENST00000380158.4_Missense_Mutation_p.T437I|RAP1GDS1_ENST00000453712.2_Missense_Mutation_p.T485I|RAP1GDS1_ENST00000264572.7_Missense_Mutation_p.T394I	NM_001100426.1|NM_001100427.1|NM_021159.4	NP_001093896.1|NP_001093897.1|NP_066982.3	P52306	GDS1_HUMAN	RAP1, GTP-GDP dissociation stimulator 1	485							binding|GTPase activator activity			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)	28				OV - Ovarian serous cystadenocarcinoma(123;2.9e-07)|LUSC - Lung squamous cell carcinoma(1;0.0253)|Lung(1;0.0576)		GTAATTAAAACCATTGTGCAG	0.333000			T	NUP98	T-ALL								13	28					0	0	1	0	0
COPS7B	64708	broad.mit.edu	37	2	232660830	232660830	+	Silent	SNP	C	C	T	rs144978316	byFrequency	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:232660830C>T	ENST00000373608.3	+	5	449	c.342C>T	c.(340-342)tcC>tcT	p.S114S	COPS7B_ENST00000409295.1_Silent_p.S80S|COPS7B_ENST00000350033.3_Silent_p.S114S|COPS7B_ENST00000410017.1_Silent_p.S114S|COPS7B_ENST00000410024.1_Silent_p.S114S|COPS7B_ENST00000409091.1_Silent_p.S7S			Q9H9Q2	CSN7B_HUMAN	COP9 signalosome subunit 7B	114	PCI.				cullin deneddylation	cytoplasm|signalosome				large_intestine(1)|liver(1)|lung(4)|ovary(1)|skin(1)	8		all_hematologic(139;0.0123)|Acute lymphoblastic leukemia(138;0.0182)|Renal(207;0.025)		Epithelial(121;1.36e-12)|BRCA - Breast invasive adenocarcinoma(100;0.00136)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		TCCCCTACTCCGTGTTGCTGA	0.478000													19	26					0	0	1	0	0
SLC14A1	6563	broad.mit.edu	37	18	43329747	43329747	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:43329747G>A	ENST00000321925.4	+	10	1233	c.1001G>A	c.(1000-1002)gGa>gAa	p.G334E	SLC14A1_ENST00000436407.3_Missense_Mutation_p.G390E|SLC14A1_ENST00000502059.2_Missense_Mutation_p.G226E|SLC14A1_ENST00000591541.1_Missense_Mutation_p.G38E|SLC14A1_ENST00000589700.1_Missense_Mutation_p.D285N|SLC14A1_ENST00000535474.1_Missense_Mutation_p.G202E|SLC14A1_ENST00000415427.3_Missense_Mutation_p.G390E|SLC14A1_ENST00000402943.2_Missense_Mutation_p.G229E|SLC14A1_ENST00000586142.1_Missense_Mutation_p.G334E	NM_001128588.3|NM_001146036.2|NM_015865.6	NP_001122060.3|NP_001139508.2|NP_056949.4	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter), member 1	334						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(11)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	21						CCCCAGGTTGGATTGCCAGCT	0.512000													28	48					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994790	140994790	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:140994790C>T	ENST00000285879.4	+	4	1886	c.1600C>T	c.(1600-1602)Cca>Tca	p.P534S	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	534							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					CCAGATTGTTCCAAGTCTTCC	0.522000										HNSCC(15;0.026)			103	32					0	0	1	0	0
ZFP28	140612	broad.mit.edu	37	19	57065936	57065936	+	Silent	SNP	C	C	T	rs61734808	byFrequency	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:57065936C>T	ENST00000301318.3	+	8	1853	c.1782C>T	c.(1780-1782)tgC>tgT	p.C594C	AC007228.11_ENST00000596587.1_RNA	NM_020828.1	NP_065879.1	Q8NHY6	ZFP28_HUMAN	ZFP28 zinc finger protein	594					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(6)|ovary(1)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	35		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		GTAAAGAGTGCGGAAAAGCTT	0.413000													45	41					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142622633	142622633	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:142622633T>A	ENST00000265310.1	-	8	1461	c.1113A>T	c.(1111-1113)aaA>aaT	p.K371N	TRPV5_ENST00000442623.1_Missense_Mutation_p.K371N	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	371					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					CCTGTAGTAGTTTTTGCTGGA	0.522000													27	34					0	0	1	0	0
ADAMTS2	9509	broad.mit.edu	37	5	178562941	178562941	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:178562941G>A	ENST00000251582.7	-	13	2155	c.2054C>T	c.(2053-2055)gCc>gTc	p.A685V		NM_014244.4	NP_055059.2	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 2	685	Cys-rich.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(31)|ovary(1)|pancreas(3)|prostate(2)|skin(7)	72	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		GAGGCTGAAGGCGTCCTTGTA	0.637000													33	40					0	0	1	0	0
HIPK2	28996	broad.mit.edu	37	7	139316456	139316456	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:139316456G>A	ENST00000406875.3	-	3	1213	c.1119C>T	c.(1117-1119)atC>atT	p.I373I	HIPK2_ENST00000342645.6_Silent_p.I373I|HIPK2_ENST00000428878.2_Silent_p.I373I	NM_022740.4	NP_073577.3	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2	373	Interaction with DAXX.|Protein kinase.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			breast(4)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Melanoma(164;0.205)					GTAAACCAAGGATGATCTCAG	0.448000													24	17					0	0	1	0	0
ACSL5	51703	broad.mit.edu	37	10	114136167	114136167	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:114136167C>T	ENST00000356116.1	+	1	212	c.100C>T	c.(100-102)Cat>Tat	p.H34Y	ACSL5_ENST00000354655.4_Intron|ACSL5_ENST00000433418.1_5'UTR|ACSL5_ENST00000393081.1_Intron|ACSL5_ENST00000354273.4_5'UTR|ACSL5_ENST00000479936.1_Intron	NM_016234.3	NP_057318.2	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	0					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|stomach(1)	21		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		GGGAAGCCCCCATTCACTAGA	0.602000													43	24					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91780202	91780202	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:91780202G>A	ENST00000389857.6	-	15	2044	c.1958C>T	c.(1957-1959)tCc>tTc	p.S653F		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	653					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				TGTCTCCAGGGAGGTCACCTT	0.632000													13	5					0	0	1	0	0
BCAS4	55653	broad.mit.edu	37	20	49434759	49434759	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:49434759G>A	ENST00000358791.5	+	2	292	c.192G>A	c.(190-192)gtG>gtA	p.V64V	BCAS4_ENST00000485049.1_3'UTR|BCAS4_ENST00000371608.2_Silent_p.V64V|BCAS4_ENST00000262591.5_Silent_p.V64V	NM_017843.3	NP_060313.3	Q8TDM0	BCAS4_HUMAN	breast carcinoma amplified sequence 4	64						cytoplasm				large_intestine(2)|lung(2)|pancreas(1)|upper_aerodigestive_tract(1)	6						CGAAGGAGGTGGAGGAGACCA	0.507000											OREG0026033	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	19					0	0	1	0	0
TRAV3	28690	broad.mit.edu	37	14	22192552	22192552	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:22192552C>T	ENST00000390425.2	+	0	503																											CTTTGTACTTCTGTGCTGTGA	0.473000													15	1					0	0	1	0	0
PLA2G4D	283748	broad.mit.edu	37	15	42379612	42379612	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:42379612C>T	ENST00000290472.3	-	3	235	c.141G>A	c.(139-141)gtG>gtA	p.V47V		NM_178034.3	NP_828848.3	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD (cytosolic)	47	C2.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(7)|ovary(1)|skin(2)|stomach(1)	27		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		GCTGTAGGATCACGTAAGGGT	0.542000													62	72					0	0	1	0	0
SPATA4	132851	broad.mit.edu	37	4	177114725	177114725	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:177114725G>A	ENST00000280191.2	-	2	335	c.227C>T	c.(226-228)tCa>tTa	p.S76L	SPATA4_ENST00000515234.1_5'UTR	NM_144644.2	NP_653245.2	Q8NEY3	SPAT4_HUMAN	spermatogenesis associated 4	76					apoptosis|spermatogenesis					NS(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(10)	22		Breast(14;0.0011)|Prostate(90;0.0129)|Melanoma(52;0.0133)|Renal(120;0.0376)|all_hematologic(60;0.124)		all cancers(43;2.9e-20)|Epithelial(43;1.99e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.58e-09)|GBM - Glioblastoma multiforme(59;0.000162)|STAD - Stomach adenocarcinoma(60;0.000543)|LUSC - Lung squamous cell carcinoma(193;0.096)		gaagccatttgaaaaatctct	0.303000													15	4					0	0	1	0	0
CARD16	114769	broad.mit.edu	37	11	104912355	104912355	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:104912355C>T	ENST00000375706.2	-	3	383	c.366G>A	c.(364-366)agG>agA	p.R122R	CASP1_ENST00000598974.1_Intron|CASP1_ENST00000594519.1_Intron|CARD16_ENST00000375704.3_3'UTR|CASP1_ENST00000593315.1_Intron|CARD16_ENST00000525374.1_3'UTR|CASP1_ENST00000415981.2_Intron	NM_001017534.1	NP_001017534.1			caspase recruitment domain family, member 16											endometrium(1)|large_intestine(1)|lung(6)|prostate(1)|skin(1)|urinary_tract(1)	11						GTTTCCATATCCTTTGAGCGT	0.443000													21	46					0	0	1	0	0
CBLB	868	broad.mit.edu	37	3	105400333	105400333	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:105400333G>A	ENST00000264122.4	-	16	2739	c.2418C>T	c.(2416-2418)atC>atT	p.I806I	CBLB_ENST00000407712.1_Intron|CBLB_ENST00000394027.3_Intron|CBLB_ENST00000403724.1_3'UTR|CBLB_ENST00000405772.1_Silent_p.I806I	NM_170662.3	NP_733762.2	Q13191	CBLB_HUMAN	Cbl proto-oncogene B, E3 ubiquitin protein ligase	806	Pro-rich.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(2)|urinary_tract(2)	49						CTAATGGAGGGATGAGAAGAT	0.438000			Mis S		AML								21	51					0	0	1	0	0
ST3GAL4	6484	broad.mit.edu	37	11	126276448	126276448	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:126276448G>T	ENST00000526727.1	+	2	471	c.97G>T	c.(97-99)Gag>Tag	p.E33*	ST3GAL4_ENST00000532243.1_Nonsense_Mutation_p.E32*|ST3GAL4_ENST00000534083.1_Nonsense_Mutation_p.E33*|ST3GAL4_ENST00000526756.1_3'UTR|ST3GAL4_ENST00000392669.2_Nonsense_Mutation_p.E33*|ST3GAL4_ENST00000534457.1_Intron|ST3GAL4_ENST00000449406.2_Nonsense_Mutation_p.E22*|ST3GAL4_ENST00000227495.6_Intron|ST3GAL4_ENST00000356132.4_Nonsense_Mutation_p.E33*|ST3GAL4_ENST00000444328.2_Nonsense_Mutation_p.E33*|ST3GAL4_ENST00000530591.1_Intron			Q11206	SIA4C_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	33					post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,3-sialyltransferase activity			endometrium(1)|large_intestine(2)|lung(5)|stomach(1)	9	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0739)|all_lung(97;0.0798)|all_neural(223;0.138)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0767)		CAGGTACATCGAGCTGTGAGT	0.577000													23	57					4.26978e-12	4.30938e-12	1	1	0
MGAM	8972	broad.mit.edu	37	7	141722209	141722209	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:141722209C>T	ENST00000475668.2	+	7	906	c.852C>T	c.(850-852)ccC>ccT	p.P284P	MGAM_ENST00000549489.2_Silent_p.P284P			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	284	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AGACCTGGCCCATATTTAACA	0.463000													15	75					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24784116	24784116	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:24784116G>A	ENST00000376451.2	+	3	1134	c.874G>A	c.(874-876)Gat>Aat	p.D292N	KIAA1217_ENST00000307544.6_Missense_Mutation_p.D292N|KIAA1217_ENST00000396446.1_Missense_Mutation_p.D292N|KIAA1217_ENST00000376452.3_Missense_Mutation_p.D574N|KIAA1217_ENST00000396445.1_Missense_Mutation_p.D292N|KIAA1217_ENST00000376454.3_Missense_Mutation_p.D609N|KIAA1217_ENST00000458595.1_Missense_Mutation_p.D574N|KIAA1217_ENST00000430453.2_Missense_Mutation_p.D495N|KIAA1217_ENST00000376462.1_Missense_Mutation_p.D529N			Q5T5P2	SKT_HUMAN	KIAA1217	609					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						GAACCACACAGATAGTGCAGG	0.423000													33	16					0	0	1	0	0
LRRN4	164312	broad.mit.edu	37	20	6021914	6021914	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:6021914C>T	ENST00000378858.4	-	5	2201	c.1977G>A	c.(1975-1977)ttG>ttA	p.L659L		NM_152611.4	NP_689824.2	Q8WUT4	LRRN4_HUMAN	leucine rich repeat neuronal 4	659	Fibronectin type-III.					integral to membrane				breast(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|skin(5)|urinary_tract(2)	27						GTGGCTGGCTCAAGCCCGCCC	0.726000													14	22					0	0	1	0	0
TEX15	56154	broad.mit.edu	37	8	30703301	30703301	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:30703301G>A	ENST00000256246.2	-	1	3307	c.3233C>T	c.(3232-3234)cCa>cTa	p.P1078L		NM_031271.3	NP_112561.2	Q9BXT5	TEX15_HUMAN	testis expressed 15	1078										NS(2)|breast(3)|cervix(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|lung(56)|ovary(5)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	138				KIRC - Kidney renal clear cell carcinoma(542;0.0918)|Kidney(114;0.111)		ATCAGCTTTTGGAGCTCTTTT	0.333000													18	31					0	0	1	0	0
ODC1	4953	broad.mit.edu	37	2	10583845	10583845	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:10583845G>A	ENST00000234111.4	-	6	1077	c.567C>T	c.(565-567)atC>atT	p.I189I	ODC1_ENST00000405333.1_Silent_p.I189I	NM_002539.1	NP_002530.1	P11926	DCOR_HUMAN	ornithine decarboxylase 1	189					polyamine biosynthetic process|regulation of cellular amino acid metabolic process|response to virus	cytosol	ornithine decarboxylase activity|protein binding			NS(1)|central_nervous_system(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|skin(3)	19	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.161)	Pyridoxal Phosphate(DB00114)|Spermine(DB00127)	CAACAACATCGATATTTAGCT	0.453000													25	80					0	0	1	0	0
NRXN2	9379	broad.mit.edu	37	11	64418968	64418968	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:64418968T>C	ENST00000265459.6	-	14	3138	c.2677A>G	c.(2677-2679)Atg>Gtg	p.M893V	AP001092.4_ENST00000433606.1_RNA|NRXN2_ENST00000377551.1_Missense_Mutation_p.M893V|NRXN2_ENST00000409571.1_Missense_Mutation_p.M886V|NRXN2_ENST00000377559.3_Missense_Mutation_p.M853V	NM_015080.3	NP_055895.1	Q9P2S2	NRX2A_HUMAN	neurexin 2	893	Laminin G-like 4.				cell adhesion	integral to membrane	metal ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(6)|urinary_tract(1)	71						CACTGGTCCATGTAGGGCTGG	0.582000											OREG0021057	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	21	30					0	0	1	0	0
SLC7A7	9056	broad.mit.edu	37	14	23282270	23282270	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:23282270C>T	ENST00000397532.3	-	2	863	c.338G>A	c.(337-339)gGa>gAa	p.G113E	SLC7A7_ENST00000397529.2_Missense_Mutation_p.G113E|SLC7A7_ENST00000397528.4_Missense_Mutation_p.G113E|SLC7A7_ENST00000285850.7_Missense_Mutation_p.G113E|SLC7A7_ENST00000555702.1_Missense_Mutation_p.G113E|SLC7A7_ENST00000554517.1_Intron			Q9UM01	YLAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, y+L system), member 7	113					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(2)	20	all_cancers(95;8.44e-05)			GBM - Glioblastoma multiforme(265;0.00741)		AGCAAGGAATCCTCCAAAGGC	0.537000													82	33					0	0	1	0	0
NLE1	54475	broad.mit.edu	37	17	33466921	33466921	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:33466921G>A	ENST00000442241.4	-	3	366	c.327C>T	c.(325-327)tcC>tcT	p.S109S	NLE1_ENST00000360831.5_Silent_p.S109S|NLE1_ENST00000593176.1_5'UTR|NLE1_ENST00000586869.1_5'UTR	NM_001014445.1|NM_018096.3	NP_001014445.1|NP_060566.2	Q9NVX2	NLE1_HUMAN	notchless homolog 1 (Drosophila)	109						nucleolus				NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|prostate(2)	22		Ovarian(249;0.17)				GACCCTCCAAGGAGCTGGTGC	0.577000													22	50					0	0	1	0	0
ZNF81	347344	broad.mit.edu	37	X	47775351	47775351	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:47775351C>G	ENST00000376954.1	+	6	1674	c.1306C>G	c.(1306-1308)Cat>Gat	p.H436D	ZNF81_ENST00000338637.7_Missense_Mutation_p.H436D			P51508	ZNF81_HUMAN	zinc finger protein 81	436						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(1)|lung(1)|skin(1)	4		all_lung(315;0.0973)				TCAGAGAATTCATACAGGAGA	0.433000													22	4					0	0	1	0	0
DENND1A	57706	broad.mit.edu	37	9	126520032	126520032	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:126520032G>A	ENST00000373624.2	-	5	453	c.252C>T	c.(250-252)ttC>ttT	p.F84F	DENND1A_ENST00000473039.1_5'UTR|DENND1A_ENST00000394215.2_Silent_p.F54F|DENND1A_ENST00000373618.1_Silent_p.F52F|DENND1A_ENST00000394219.3_Silent_p.F52F|DENND1A_ENST00000373620.3_Silent_p.F84F	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	84	UDENN.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						GGCAGAACCCGAATCTCTGTT	0.493000													26	3					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887371	12887371	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:12887371C>T	ENST00000535591.1	-	3	681	c.486G>A	c.(484-486)gtG>gtA	p.V162V		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	162										NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						AGTCTAGGTTCACCATTTTCA	0.463000													53	330					0	0	1	0	0
RRP7A	27341	broad.mit.edu	37	22	42912125	42912125	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:42912125G>A	ENST00000323013.6	-	3	249	c.234C>T	c.(232-234)ctC>ctT	p.L78L		NM_015703.4	NP_056518.2	Q9Y3A4	RRP7A_HUMAN	ribosomal RNA processing 7 homolog A (S. cerevisiae)	78	RRM.						nucleotide binding|RNA binding			central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|lung(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	10						AGGTGGACAGGAGGCGGGACA	0.622000													17	7					0	0	1	0	0
GOT1L1	137362	broad.mit.edu	37	8	37794819	37794819	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:37794819G>A	ENST00000307599.4	-	4	594	c.495C>T	c.(493-495)ccC>ccT	p.P165P		NM_152413.2	NP_689626.2	Q8NHS2	AATC2_HUMAN	glutamic-oxaloacetic transaminase 1-like 1	165					biosynthetic process|cellular amino acid metabolic process	cytoplasm	pyridoxal phosphate binding|transaminase activity			central_nervous_system(1)|endometrium(3)|lung(8)|ovary(1)|prostate(1)	14	Colorectal(12;0.00627)	Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;1.37e-11)			GGAGTATGTCGGGGTCCATGC	0.532000													11	17					0	0	1	0	0
GRID2	2895	broad.mit.edu	37	4	94159601	94159601	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:94159601G>A	ENST00000282020.4	+	8	1463	c.1205G>A	c.(1204-1206)gGa>gAa	p.G402E	GRID2_ENST00000510992.1_Missense_Mutation_p.G307E	NM_001510.2	NP_001501.2	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	402					glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(18)|lung(45)|ovary(3)|prostate(6)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(1)	100		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	GAAATCCTTGGAACCAACTAT	0.413000													11	70					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32502613	32502613	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:32502613G>A	ENST00000286827.3	-	26	4434	c.3963C>T	c.(3961-3963)tcC>tcT	p.S1321S	TIAM1_ENST00000541036.1_Silent_p.S1261S	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1321	PH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CCTCATAAATGGAAAGCCTGT	0.527000													62	77					0	0	1	0	0
CTCFL	140690	broad.mit.edu	37	20	56078574	56078574	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:56078574C>T	ENST00000429804.2	-	9	2168	c.1608G>A	c.(1606-1608)aaG>aaA	p.K536K	CTCFL_ENST00000243914.3_Silent_p.K586K|CTCFL_ENST00000433949.2_Silent_p.K586K|CTCFL_ENST00000426658.2_3'UTR|CTCFL_ENST00000423479.2_Silent_p.K586K|CTCFL_ENST00000422109.2_3'UTR|CTCFL_ENST00000371196.2_Silent_p.K586K|CTCFL_ENST00000502686.2_Silent_p.K324K	NM_001269046.1	NP_001255975.1	Q8NI51	CTCFL_HUMAN	CCCTC-binding factor (zinc finger protein)-like	586					cell cycle|DNA methylation involved in gamete generation|histone methylation|positive regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|regulation of histone H3-K4 methylation|transcription, DNA-dependent	cytoplasm|nucleus	histone binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(9)|lung(28)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58	Lung NSC(12;0.00132)|all_lung(29;0.00433)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;3.95e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.09e-07)			TCTGCTTCCTCTTTCTTGTTC	0.507000													52	102					0	0	1	0	0
ACPP	55	broad.mit.edu	37	3	132063785	132063785	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:132063785C>T	ENST00000336375.5	+	7	753	c.663C>T	c.(661-663)ttC>ttT	p.F221F	ACPP_ENST00000475741.1_Silent_p.F188F|ACPP_ENST00000351273.7_Silent_p.F221F	NM_001099.4	NP_001090.2	P15309	PPAP_HUMAN	acid phosphatase, prostate	221						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(5)|lung(13)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	27						TTCACAATTTCACTTTACCCT	0.398000													32	51					0	0	1	0	0
DSN1	79980	broad.mit.edu	37	20	35390870	35390870	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:35390870G>A	ENST00000426836.1	-	6	956	c.584C>T	c.(583-585)tCa>tTa	p.S195L	DSN1_ENST00000373740.3_Missense_Mutation_p.S123L|DSN1_ENST00000473615.1_5'UTR|DSN1_ENST00000373745.3_Missense_Mutation_p.S195L|DSN1_ENST00000373750.4_Missense_Mutation_p.S195L|DSN1_ENST00000448110.1_Missense_Mutation_p.S179L|DSN1_ENST00000373734.4_Missense_Mutation_p.S88L	NM_001145316.1	NP_001138788.1	Q9H410	DSN1_HUMAN	DSN1, MIS12 kinetochore complex component	195					cell division|chromosome segregation|mitotic prometaphase	cytosol|MIS12/MIND type complex|nucleus	protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	16		Myeloproliferative disorder(115;0.00874)				TTACCCATTTGAATCTTCAAA	0.423000													5	17					0	0	1	0	0
FSTL5	56884	broad.mit.edu	37	4	162463704	162463704	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:162463704G>A	ENST00000306100.5	-	9	1593	c.1157C>T	c.(1156-1158)tCc>tTc	p.S386F	FSTL5_ENST00000379164.4_Missense_Mutation_p.S385F|FSTL5_ENST00000427802.2_Missense_Mutation_p.S385F|FSTL5_ENST00000536695.1_Missense_Mutation_p.S385F	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	386	Ig-like 2.					extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		GAGTTGTTTGGAAAGCTTTGG	0.388000													44	24					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51872005	51872005	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:51872005C>T	ENST00000371497.5	+	2	2895	c.2008C>T	c.(2008-2010)Ctg>Ttg	p.L670L	TSHZ2_ENST00000603338.2_Silent_p.L667L|TSHZ2_ENST00000329613.6_Silent_p.L667L	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	670					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			ACCCCAGCCCCTGGAGCCCAC	0.612000													19	57					0	0	1	0	0
DKK2	27123	broad.mit.edu	37	4	107847042	107847042	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:107847042C>T	ENST00000285311.3	-	2	992	c.287G>A	c.(286-288)gGa>gAa	p.G96E	DKK2_ENST00000513208.1_5'UTR|DKK2_ENST00000510463.1_Missense_Mutation_p.G50E	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	96	DKK-type Cys-1.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		GGCCGATGATCCTTGGTGGGG	0.512000													14	59					0	0	1	0	0
ADPRHL1	113622	broad.mit.edu	37	13	114088062	114088062	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:114088062G>A	ENST00000356501.4	-	3	429	c.254C>T	c.(253-255)cCc>cTc	p.P85L	ADPRHL1_ENST00000375418.3_Missense_Mutation_p.P167L	NM_199162.1	NP_954631.1	Q8NDY3	ARHL1_HUMAN	ADP-ribosylhydrolase like 1	167					protein de-ADP-ribosylation		ADP-ribosylarginine hydrolase activity|magnesium ion binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(6)|skin(1)	11	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0395)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0977)|Breast(118;0.188)	all cancers(43;0.0195)|GBM - Glioblastoma multiforme(44;0.116)			CTTACCTGTGGGATGGTTGTG	0.662000													4	3					0	0	1	0	0
ALB	213	broad.mit.edu	37	4	74280830	74280830	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:74280830C>T	ENST00000295897.4	+	9	1226	c.1137C>T	c.(1135-1137)acC>acT	p.T379T	ALB_ENST00000415165.2_Silent_p.T187T|ALB_ENST00000503124.1_Silent_p.T229T|ALB_ENST00000509063.1_Silent_p.T379T|ALB_ENST00000505649.1_3'UTR|ALB_ENST00000401494.3_Silent_p.T264T	NM_000477.5	NP_000468.1	P02768	ALBU_HUMAN	albumin	379	Albumin 2.				bile acid and bile salt transport|bile acid metabolic process|cellular response to starvation|hemolysis by symbiont of host erythrocytes|lipoprotein metabolic process|maintenance of mitochondrion location|negative regulation of apoptosis|platelet activation|platelet degranulation|sodium-independent organic anion transport|transmembrane transport	extracellular space|platelet alpha granule lumen|protein complex	antioxidant activity|chaperone binding|copper ion binding|DNA binding|drug binding|fatty acid binding|pyridoxal phosphate binding|toxin binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(6)|liver(9)|lung(16)|ovary(3)|prostate(2)|skin(4)|stomach(1)|urinary_tract(1)	48	Breast(15;0.00102)		Epithelial(6;4.8e-05)|OV - Ovarian serous cystadenocarcinoma(6;0.000263)|all cancers(17;0.000472)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)		Acenocoumarol(DB01418)|Acitretin(DB00459)|Alfentanil(DB00802)|Aluminium(DB01370)|Auranofin(DB00995)|Bismuth(DB01402)|Captopril(DB01197)|Carboplatin(DB00958)|Cefalotin(DB00456)|Cefazolin(DB01327)|Cefonicid(DB01328)|Cefoperazone(DB01329)|Chlorpheniramine(DB01114)|Chlorpromazine(DB00477)|Ciprofloxacin(DB00537)|Clonazepam(DB01068)|Cloxacillin(DB01147)|Cytarabine(DB00987)|Dantrolene(DB01219)|Diclofenac(DB00586)|Diflunisal(DB00861)|Digitoxin(DB01396)|Estrone(DB00655)|Ethacrynic acid(DB00903)|Etodolac(DB00749)|Flurbiprofen(DB00712)|Gadobenate Dimeglumine(DB00743)|Gatifloxacin(DB01044)|Gliclazide(DB01120)|Halothane(DB01159)|Human Serum Albumin(DB00062)|Hyaluronidase(DB00070)|Ibuprofen(DB01050)|Insulin-detemir(DB01307)|Insulin-glargine(DB01308)|Iodipamide(DB04711)|Ketoprofen(DB01009)|Levamisole(DB00848)|Levothyroxine(DB00451)|Liothyronine(DB00279)|Mefenamic acid(DB00784)|Mephenytoin(DB00532)|Methotrexate(DB00563)|Nortriptyline(DB00540)|Oxazepam(DB00842)|Paclitaxel(DB01229)|Phenprocoumon(DB00946)|Probenecid(DB01032)|Propofol(DB00818)|Pyridoxine(DB00165)|Salicyclic acid(DB00936)|Saquinavir(DB01232)|Serum albumin iodonated(DB00064)|Serum albumin(DB00096)|Sodium lauryl sulfate(DB00815)|Sucralfate(DB00364)|Sulfamethizole(DB00576)|Sulindac(DB00605)|Suprofen(DB00870)|Testosterone(DB00624)|Xanthophyll(DB00137)	CATATGAAACCACTCTAGAGA	0.388000													59	40					0	0	1	0	0
KCTD3	51133	broad.mit.edu	37	1	215751403	215751403	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:215751403C>T	ENST00000259154.4	+	6	670	c.376C>T	c.(376-378)Cat>Tat	p.H126Y		NM_016121.3	NP_057205.2	Q9Y597	KCTD3_HUMAN	potassium channel tetramerization domain containing 3	126						voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			breast(4)|endometrium(2)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|prostate(1)|skin(1)	33				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		TGTCCTTTTTCATGGTTACTT	0.353000													12	100					0	0	1	0	0
ITGA4	3676	broad.mit.edu	37	2	182339987	182339987	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:182339987G>A	ENST00000397033.2	+	4	958	c.528G>A	c.(526-528)ctG>ctA	p.L176L	ITGA4_ENST00000339307.4_Silent_p.L176L|ITGA4_ENST00000478440.1_Intron	NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	176					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity	p.L176L(1)		breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GAACAGAACTGAGTAAAAGAA	0.343000													28	53					0	0	1	0	0
CDH13	1012	broad.mit.edu	37	16	83520158	83520158	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:83520158C>T	ENST00000566620.1	+	7	1148	c.858C>T	c.(856-858)atC>atT	p.I286I	CDH13_ENST00000428848.3_Silent_p.I247I|CDH13_ENST00000569454.1_3'UTR|CDH13_ENST00000268613.10_Silent_p.I333I	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	286	Cadherin 2.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		GGTATAATATCCGTCAGCAGA	0.542000													28	31					0	0	1	0	0
NRBP2	340371	broad.mit.edu	37	8	144919303	144919303	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:144919303G>A	ENST00000442628.2	-	14	1310	c.1171C>T	c.(1171-1173)Ctg>Ttg	p.L391L	NRBP2_ENST00000327830.5_Silent_p.L148L	NM_178564.3	NP_848659.2	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2	391					negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)|kidney(1)|large_intestine(2)	5	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GGCAGCCCCAGGGGTCGAGTG	0.637000													27	37					0	0	1	0	0
ANKRD35	148741	broad.mit.edu	37	1	145560142	145560142	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:145560142G>A	ENST00000355594.4	+	8	715	c.628G>A	c.(628-630)Gct>Act	p.A210T	ANKRD35_ENST00000544626.1_3'UTR	NM_144698.3	NP_653299.3	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	210										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GAGCCACGGAGCTGACGCGGG	0.582000													85	35					0	0	1	0	0
ALPI	248	broad.mit.edu	37	2	233322730	233322730	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:233322730G>A	ENST00000295463.3	+	8	956	c.879G>A	c.(877-879)acG>acA	p.T293T		NM_001631.3	NP_001622.2	P09923	PPBI_HUMAN	alkaline phosphatase, intestinal	293					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(2)|upper_aerodigestive_tract(1)	24		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		CCGGAGACACGAAATATGAGA	0.622000													33	31					0	0	1	0	0
SPZ1	84654	broad.mit.edu	37	5	79616265	79616265	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:79616265A>T	ENST00000296739.4	+	1	476	c.231A>T	c.(229-231)aaA>aaT	p.K77N		NM_032567.3	NP_115956.3	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	77					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			endometrium(2)|kidney(5)|large_intestine(4)|lung(12)|ovary(1)|skin(2)	26		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		AAGAAATTAAAGATATTCTTA	0.378000													32	28					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138425405	138425405	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:138425405C>T	ENST00000409968.1	+	27	4891	c.4713C>T	c.(4711-4713)ttC>ttT	p.F1571F	THSD7B_ENST00000413152.2_Silent_p.F1543F|THSD7B_ENST00000272643.3_Silent_p.F1574F					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		TCATGATTTTCCTAATATTTA	0.313000													4	7					0	0	1	0	0
TCHHL1	126637	broad.mit.edu	37	1	152060596	152060596	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:152060596G>A	ENST00000368806.1	-	2	88	c.24C>T	c.(22-24)gtC>gtT	p.V8V		NM_001008536.1	NP_001008536.1	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	8							calcium ion binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(9)|lung(33)|ovary(2)|prostate(1)|skin(7)|stomach(1)	60	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TTACACAGAGGACATTTCTCA	0.473000													62	36					0	0	1	0	0
SPATA16	83893	broad.mit.edu	37	3	172834968	172834968	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:172834968G>A	ENST00000351008.3	-	2	737	c.554C>T	c.(553-555)tCt>tTt	p.S185F		NM_031955.5	NP_114161.3	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	185					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			breast(2)|cervix(1)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	43	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			TCTATAGCAAGAGCTGGCATC	0.418000													50	58					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30721365	30721365	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:30721365C>T	ENST00000262518.4	+	8	1435	c.1050C>T	c.(1048-1050)ccC>ccT	p.P350P	SRCAP_ENST00000395059.2_Silent_p.P350P|SRCAP_ENST00000344771.4_Silent_p.P350P	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	350	Glu-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CTTCCAGCCCCTCTCAAACCC	0.577000													28	30					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220354624	220354624	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:220354624C>T	ENST00000312358.7	+	36	9016	c.8884C>T	c.(8884-8886)Cct>Tct	p.P2962S	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	2962	Pro-rich.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		ACAGGGTCCCCCTCAGAAACC	0.632000													23	21					0	0	1	0	0
CYP2J2	1573	broad.mit.edu	37	1	60375600	60375600	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:60375600G>A	ENST00000371204.3	-	5	760	c.717C>T	c.(715-717)ttC>ttT	p.F239F	CYP2J2_ENST00000492633.1_5'UTR	NM_000775.2	NP_000766.2	P51589	CP2J2_HUMAN	cytochrome P450, family 2, subfamily J, polypeptide 2	239					epoxygenase P450 pathway|linoleic acid metabolic process|regulation of heart contraction|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	arachidonic acid 11,12-epoxygenase activity|arachidonic acid 14,15-epoxygenase activity|aromatase activity|electron carrier activity|heme binding|linoleic acid epoxygenase activity			NS(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|skin(1)	26	all_cancers(7;0.000396)					GTCCAGGCAGGAATTTCATTA	0.363000													9	42					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	2000354	2000354	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:2000354C>T	ENST00000262113.4	+	3	327	c.186C>T	c.(184-186)tcC>tcT	p.S62S	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	62					muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		GCCAGACGTCCCTGGGAGGAA	0.577000													27	85					0	0	1	0	0
KERA	11081	broad.mit.edu	37	12	91449939	91449939	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:91449939G>A	ENST00000266719.3	-	2	367	c.120C>T	c.(118-120)ttC>ttT	p.F40F		NM_007035.3	NP_008966.1	O60938	KERA_HUMAN	keratocan	40	LRRNT.				response to stimulus|visual perception	proteinaceous extracellular matrix				breast(2)|large_intestine(8)|lung(5)|prostate(2)|skin(2)	19						TGGGACACTCGAAGTCATGAA	0.398000													10	33					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150174466	150174466	+	Silent	SNP	C	C	T	rs140854559		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:150174466C>T	ENST00000307271.3	+	5	2170	c.1596C>T	c.(1594-1596)ttC>ttT	p.F532F		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	532						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding	p.F532F(1)		breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		TCCTGGTGTTCCAGCTGGGAC	0.498000													21	29					0	0	1	0	0
SLC8B1	80024	broad.mit.edu	37	12	113770644	113770644	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:113770644C>T	ENST00000552014.1	-	3	555	c.40G>A	c.(40-42)Gtg>Atg	p.V14M	SLC24A6_ENST00000553238.1_5'UTR|SLC24A6_ENST00000546737.1_Missense_Mutation_p.V14M|SLC24A6_ENST00000202831.3_Missense_Mutation_p.V14M			Q6J4K2	NCKX6_HUMAN		14					response to stimulus|sodium ion transport	integral to membrane|plasma membrane	calcium:cation antiporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(3)|skin(1)	16						ACACAAAGCACACTCAGTGCC	0.582000													13	31					0	0	1	0	0
SPATA31D5P	347127	broad.mit.edu	37	9	84530324	84530324	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:84530324C>T	ENST00000527857.1	+	0	346					NR_026851.1																						CCTCCTGCTTCCTGCAGTCCC	0.562000													4	2					0	0	1	0	0
HSD3B1	3283	broad.mit.edu	37	1	120056552	120056552	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:120056552G>A	ENST00000235547.6	+	4	551	c.412G>A	c.(412-414)Gaa>Aaa	p.E138K	HSD3B1_ENST00000528909.1_Missense_Mutation_p.E136K|HSD3B1_ENST00000369413.3_Missense_Mutation_p.E136K	NM_000862.2	NP_000853.1	P14060	3BHS1_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	136					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(18)|ovary(2)|prostate(1)|skin(1)	32	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	CTCCTACAAGGAAATCATCCA	0.537000													189	75					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52493941	52493941	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:52493941G>A	ENST00000216286.5	-	12	2651	c.2652C>T	c.(2650-2652)gcC>gcT	p.A884A	NID2_ENST00000541773.1_Intron	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	884	EGF-like 4.					basement membrane	calcium ion binding|collagen binding	p.A884A(1)		NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					GCCCATCGCCGGCATAACCAG	0.587000													9	1					0	0	1	0	0
SLCO1B7	338821	broad.mit.edu	37	12	21172275	21172275	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:21172275G>A	ENST00000421593.2	+	2	179	c.179G>A	c.(178-180)gGa>gAa	p.G60E	SLCO1B3_ENST00000553473.1_Intron|LST3_ENST00000540229.1_Intron|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron	NM_001009562.4	NP_001009562.3			solute carrier organic anion transporter family, member 1B7 (non-functional)											endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(25)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	46						ATGGGAACTGGAAGTATTTTG	0.333000													15	15					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37732413	37732413	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:37732413G>A	ENST00000330843.4	-	3	1254	c.1242C>T	c.(1240-1242)ccC>ccT	p.P414P	RAB11FIP1_ENST00000524118.1_Silent_p.P266P|RAB11FIP1_ENST00000287263.4_Silent_p.P414P|RAB11FIP1_ENST00000522727.1_Silent_p.P266P	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	414					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			CTGAGTTTGCGGGGGCCATGT	0.557000													37	53					0	0	1	0	0
THBS3	7059	broad.mit.edu	37	1	155173095	155173095	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:155173095C>T	ENST00000368378.3	-	6	695	c.673_splice	c.e6-1	p.G225_splice	THBS3_ENST00000541990.1_5'UTR|THBS3_ENST00000428962.2_Intron|THBS3_ENST00000457183.2_Splice_Site_p.G105_splice|RP11-263K19.4_ENST00000422665.1_RNA|RP11-263K19.4_ENST00000430312.1_RNA|RP11-263K19.4_ENST00000453136.1_RNA|THBS3_ENST00000487250.1_5'UTR	NM_001252607.1|NM_007112.4	NP_001239536.1|NP_009043.1	P49746	TSP3_HUMAN	thrombospondin 3	225					cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(6)|endometrium(4)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(3)	48	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TGGTCTGCTCCCCTGTCGGGA	0.627000													36	5					0	0	1	0	0
COL18A1	80781	broad.mit.edu	37	21	46916415	46916415	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:46916415G>A	ENST00000359759.4	+	29	3776	c.3753_splice	c.e29-1	p.G1252_splice	COL18A1_ENST00000400337.2_Splice_Site_p.G837_splice|COL18A1_ENST00000355480.5_Splice_Site_p.G1017_splice|COL18A1_ENST00000459895.1_3'UTR			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	1252	Triple-helical region 6 (COL6).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		TCCCCACAGGGAATGCCCGGC	0.597000													41	64					0	0	1	0	0
SPERT	220082	broad.mit.edu	37	13	46287917	46287917	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:46287917G>A	ENST00000378966.3	+	2	1065	c.649G>A	c.(649-651)Gag>Aag	p.E217K	SPERT_ENST00000310521.1_Missense_Mutation_p.E253K			Q8NA61	SPERT_HUMAN	spermatid associated	253						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		CCTCCGGGAGGAGAATCGCGC	0.682000													8	17					0	0	1	0	0
STARD3	10948	broad.mit.edu	37	17	37817337	37817337	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:37817337C>T	ENST00000336308.5	+	13	1356	c.1139_splice	c.e13+1	p.R380_splice	STARD3_ENST00000544210.2_Splice_Site_p.R380_splice|STARD3_ENST00000580611.1_Splice_Site_p.R354_splice|STARD3_ENST00000394250.4_Splice_Site_p.R362_splice	NM_001165937.1|NM_006804.3	NP_001159409.1|NP_006795.3	Q14849	STAR3_HUMAN	StAR-related lipid transfer (START) domain containing 3	380	START.				cholesterol metabolic process|mitochondrial transport|steroid biosynthetic process	integral to membrane|late endosome membrane	cholesterol binding|cholesterol transporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|prostate(2)|stomach(1)	14	Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;1.04e-44)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CAAATATGTCCGGTGAGCCTC	0.617000													20	25					0	0	1	0	0
GJA10	84694	broad.mit.edu	37	6	90604405	90604405	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:90604405C>T	ENST00000369352.1	+	1	218	c.218C>T	c.(217-219)tCt>tTt	p.S73F		NM_032602.1	NP_115991.1	Q969M2	CXA10_HUMAN	gap junction protein, alpha 10, 62kDa	73					synaptic transmission	connexon complex|integral to membrane	gap junction channel activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|skin(3)|urinary_tract(1)	37		all_cancers(76;5.71e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00527)		BRCA - Breast invasive adenocarcinoma(108;0.0915)		TTCCCTATCTCTTTGATCAGG	0.463000													10	28					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44576027	44576027	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:44576027C>T	ENST00000289547.4	-	4	1737	c.1681_splice	c.e4-1	p.G561_splice	NPC1L1_ENST00000546276.1_Splice_Site_p.G561_splice|NPC1L1_ENST00000423141.1_Splice_Site_p.G561_splice|NPC1L1_ENST00000381160.3_Splice_Site_p.G561_splice	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	561					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	ATAGTCCTTTCCTGGGATAAG	0.602000													18	81					0	0	1	0	0
PKHD1	5314	broad.mit.edu	37	6	51612713	51612713	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:51612713G>A	ENST00000371117.3	-	58	9976	c.9701C>T	c.(9700-9702)tCc>tTc	p.S3234F	PKHD1_ENST00000340994.4_Missense_Mutation_p.S3234F	NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3234					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					TCTTGGATTGGAGGGAGCTCT	0.483000													16	100					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143771320	143771320	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:143771320G>A	ENST00000408898.2	+	1	46	c.8G>A	c.(7-9)gGa>gAa	p.G3E		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	3					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					GAAATGGGGGGAAATCAGACT	0.448000													33	45					0	0	1	0	0
SGMS1	259230	broad.mit.edu	37	10	52103734	52103734	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:52103734G>A	ENST00000361781.2	-	7	1100	c.141C>T	c.(139-141)ccC>ccT	p.P47P	SGMS1_ENST00000429490.1_Intron|SGMS1_ENST00000361543.2_Silent_p.P47P	NM_147156.3	NP_671512.1	Q86VZ5	SMS1_HUMAN	sphingomyelin synthase 1	53	SAM.				apoptosis|cell growth|sphingomyelin biosynthetic process	endoplasmic reticulum|Golgi trans cisterna|integral to Golgi membrane|nucleus|plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			endometrium(1)|kidney(1)|large_intestine(5)|liver(1)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16						GGCACAAGGGGGGTTTTTTGA	0.512000													26	6					0	0	1	0	0
LMTK3	114783	broad.mit.edu	37	19	49012224	49012224	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:49012224C>T	ENST00000600059.1	-	5	668	c.441G>A	c.(439-441)gtG>gtA	p.V147V	LMTK3_ENST00000270238.3_Silent_p.V176V					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		CTCCCAGGATCACCTGGTCAA	0.667000													19	40					0	0	1	0	0
FOXD4L1	200350	broad.mit.edu	37	2	114257523	114257523	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:114257523C>T	ENST00000306507.5	+	1	863	c.690C>T	c.(688-690)ccC>ccT	p.P230P		NM_012184.4	NP_036316.1	Q9NU39	FX4L1_HUMAN	forkhead box D4-like 1	230	Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(2)	26						TGCACAACCCCCGCCCAGGCC	0.721000													69	93					0	0	1	0	0
R3HCC1L	27291	broad.mit.edu	37	10	99968038	99968038	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:99968038T>A	ENST00000298999.3	+	5	470	c.167T>A	c.(166-168)cTc>cAc	p.L56H	R3HCC1L_ENST00000314594.5_5'UTR|R3HCC1L_ENST00000370584.3_Missense_Mutation_p.L56H|R3HCC1L_ENST00000370586.2_Intron	NM_014472.4	NP_055287.4			R3H domain and coiled-coil containing 1-like																		GAAAGTTCTCTCTCCCAAAAA	0.393000													36	19					0	0	1	0	0
DEAF1	10522	broad.mit.edu	37	11	687964	687964	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:687964G>A	ENST00000382409.3	-	4	1095	c.611C>T	c.(610-612)cCc>cTc	p.P204L	DEAF1_ENST00000338675.6_Missense_Mutation_p.P204L	NM_021008.2	NP_066288.2	O75398	DEAF1_HUMAN	DEAF1 transcription factor	204	SAND.				embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		GCACCGTACGGGCAGCTCACT	0.552000													21	24					0	0	1	0	0
TXNDC11	51061	broad.mit.edu	37	16	11785402	11785402	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:11785402G>A	ENST00000356957.3	-	9	1832	c.1725C>T	c.(1723-1725)tcC>tcT	p.S575S	TXNDC11_ENST00000283033.5_Silent_p.S548S			Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	575					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane				endometrium(3)|large_intestine(5)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	21						TGTGAGGAACGGAGCTTGGGG	0.478000													53	69					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86591737	86591737	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:86591737G>A	ENST00000370571.2	-	3	648	c.282C>T	c.(280-282)ttC>ttT	p.F94F	COL24A1_ENST00000436319.1_Silent_p.F94F	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	94	TSP N-terminal.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		AAATTTTCACGAAAGGTGTCT	0.408000													8	63					0	0	1	0	0
OTOF	9381	broad.mit.edu	37	2	26781365	26781365	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:26781365G>A	ENST00000272371.2	-	1	201	c.75C>T	c.(73-75)ttC>ttT	p.F25F	OTOF_ENST00000403946.3_Silent_p.F25F	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	25					cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCCTACCTCGGAAAGTCACTT	0.652000													46	44					0	0	1	0	0
ANKRD33	341405	broad.mit.edu	37	12	52282027	52282027	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:52282027G>A	ENST00000301190.6	+	1	284	c.57G>A	c.(55-57)ctG>ctA	p.L19L	ANKRD33_ENST00000538991.1_5'UTR|ANKRD33_ENST00000340970.4_5'UTR	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	0										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		TAGTCCACCTGGAGGCATTCG	0.567000													55	54					0	0	1	0	0
DRD5	1816	broad.mit.edu	37	4	9784199	9784199	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:9784199G>A	ENST00000304374.2	+	1	942	c.546G>A	c.(544-546)agG>agA	p.R182R		NM_000798.4	NP_000789.1	P21918	DRD5_HUMAN	dopamine receptor D5	182					activation of adenylate cyclase activity by dopamine receptor signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|cellular calcium ion homeostasis|negative regulation of NAD(P)H oxidase activity|reactive oxygen species metabolic process|synaptic transmission, dopaminergic	integral to plasma membrane				NS(2)|endometrium(8)|kidney(4)|large_intestine(8)|lung(22)|prostate(7)|skin(3)|stomach(2)|urinary_tract(1)	57					Apomorphine(DB00714)|Carphenazine(DB01038)|Fenoldopam(DB00800)|Zuclopenthixol(DB01624)	ACTGGCACAGGGACCAGGCGG	0.617000													15	63					0	0	1	0	0
BCL6B	255877	broad.mit.edu	37	17	6930341	6930341	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:6930341C>T	ENST00000293805.5	+	8	1350	c.1258C>T	c.(1258-1260)Cgc>Tgc	p.R420C		NM_181844.3	NP_862827.1	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B	420						nucleus	zinc ion binding			skin(1)	1						CTGCGGAACCCGCTTCCGCCA	0.637000													37	17					0	0	1	0	0
DSC3	1825	broad.mit.edu	37	18	28577002	28577002	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:28577002C>T	ENST00000434452.1	-	15	2402	c.2248G>A	c.(2248-2250)Gga>Aga	p.G750R	DSC3_ENST00000360428.4_Missense_Mutation_p.G750R	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	750					homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			GTCATAAATCCATTGGCAGAG	0.368000													11	50					0	0	1	0	0
ALG9	79796	broad.mit.edu	37	11	111749855	111749855	+	Translation_Start_Site	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:111749855A>T	ENST00000524880.1	-	1	294	c.2T>A	c.(1-3)aTg>aAg	p.M1K	C11orf1_ENST00000528125.1_Intron|FDXACB1_ENST00000260257.4_Start_Codon_SNP_p.M1K			Q9H6U8	ALG9_HUMAN	ALG9, alpha-1,2-mannosyltransferase	0					dolichol-linked oligosaccharide biosynthetic process|GPI anchor biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		CCGAGGGGCCATGGCCTCCAC	0.622000											OREG0021330	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	34					0	0	1	0	0
PIP5K1B	8395	broad.mit.edu	37	9	71509462	71509462	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:71509462G>A	ENST00000265382.3	+	8	984	c.679G>A	c.(679-681)Gac>Aac	p.D227N	PIP5K1B_ENST00000541509.1_Missense_Mutation_p.D227N	NM_003558.2	NP_003549.1	O14986	PI51B_HUMAN	phosphatidylinositol-4-phosphate 5-kinase, type I, beta	227	PIPK.					endomembrane system|membrane|uropod	1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|protein binding			breast(1)|large_intestine(2)|stomach(1)	4				Lung(182;0.133)		CACATTTAAGGACTTAGATTT	0.433000													38	13					0	0	1	0	0
CPN1	1369	broad.mit.edu	37	10	101835839	101835839	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:101835839C>T	ENST00000370418.3	-	2	500	c.249G>A	c.(247-249)ggG>ggA	p.G83G		NM_001308.2	NP_001299.1	P15169	CBPN_HUMAN	carboxypeptidase N, polypeptide 1	83	Catalytic.				proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	33		Colorectal(252;0.234)		Epithelial(162;4.77e-10)|all cancers(201;3.82e-08)		CGTGCATGTTCCCCACATACT	0.542000													29	21					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82434966	82434966	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:82434966C>T	ENST00000370728.1	+	17	3261	c.2616C>T	c.(2614-2616)ttC>ttT	p.F872F	LPHN2_ENST00000359929.3_Silent_p.F859F|LPHN2_ENST00000271029.4_Silent_p.F872F|LPHN2_ENST00000370725.1_Silent_p.F872F|LPHN2_ENST00000370727.1_Silent_p.F872F|LPHN2_ENST00000319517.6_Silent_p.F859F|LPHN2_ENST00000394879.1_Silent_p.F859F|LPHN2_ENST00000370723.1_Silent_p.F859F|LPHN2_ENST00000370721.1_Silent_p.F797F|LPHN2_ENST00000370713.1_Silent_p.F859F|LPHN2_ENST00000335786.5_Silent_p.F872F|LPHN2_ENST00000370717.2_Silent_p.F872F|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370715.1_Silent_p.F859F|LPHN2_ENST00000370730.1_Silent_p.F872F			O95490	LPHN2_HUMAN	latrophilin 2	872					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding			NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		TCTGCTTTTTCCGTGGCCTAC	0.393000													77	39					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179665129	179665129	+	Silent	SNP	C	C	T	rs150591951		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179665129C>T	ENST00000589042.1	-	4	800	c.576G>A	c.(574-576)ctG>ctA	p.L192L	TTN_ENST00000342992.6_Silent_p.L192L|TTN_ENST00000591111.1_Silent_p.L192L|TTN_ENST00000360870.5_Silent_p.L192L|TTN_ENST00000460472.2_Silent_p.L192L|TTN_ENST00000342175.6_Silent_p.L192L|TTN_ENST00000359218.5_Silent_p.L192L	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	192	Ig-like 2.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.L192L(3)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACCTTGAACCAGTAATTCAG	0.512000													72	88					0	0	1	0	0
UBE2R2	54926	broad.mit.edu	37	9	33886894	33886894	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:33886894C>T	ENST00000263228.3	+	2	384	c.193C>T	c.(193-195)Cct>Tct	p.P65S		NM_017811.3	NP_060281.2	Q712K3	UB2R2_HUMAN	ubiquitin-conjugating enzyme E2R 2	65					protein K48-linked ubiquitination|protein monoubiquitination		ATP binding|ubiquitin-protein ligase activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(3)	8			LUSC - Lung squamous cell carcinoma(29;0.0176)	GBM - Glioblastoma multiforme(74;0.188)		TATTAAATTTCCTATTGACTA	0.363000													13	7					0	0	1	0	0
ANGPTL1	9068	broad.mit.edu	37	1	178834189	178834189	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:178834189C>T	ENST00000234816.2	-	3	1170	c.723G>A	c.(721-723)agG>agA	p.R241R	RALGPS2_ENST00000367634.2_Intron|RALGPS2_ENST00000367635.3_Intron|RALGPS2_ENST00000324778.4_Intron|ANGPTL1_ENST00000367629.1_Silent_p.R241R	NM_004673.3	NP_004664.1	O95841	ANGL1_HUMAN	angiopoietin-like 1	241						extracellular space	receptor binding			breast(2)|endometrium(1)|large_intestine(2)|lung(7)|pancreas(1)|skin(1)	14						AACCTGGATCCCTCTGAATCT	0.493000													15	77					0	0	1	0	0
CCND2	894	broad.mit.edu	37	12	4409122	4409122	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:4409122G>A	ENST00000261254.3	+	5	1086	c.817G>A	c.(817-819)Gat>Aat	p.D273N		NM_001759.3	NP_001750.1	P30279	CCND2_HUMAN	cyclin D2	273					cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	17			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			CAAGTCGGAGGATGAACTGGA	0.562000			T	IGL@	"""NHL,CLL"""								4	26					0	0	1	0	0
HTR2C	3358	broad.mit.edu	37	X	114141163	114141163	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:114141163C>T	ENST00000276198.1	+	6	1290	c.562C>T	c.(562-564)Cct>Tct	p.P188S	HTR2C_ENST00000371950.3_Missense_Mutation_p.S156F|HTR2C_ENST00000371951.1_Missense_Mutation_p.P188S	NM_000868.2	NP_000859.1	P28335	5HT2C_HUMAN	5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled	188					cGMP biosynthetic process|ERK1 and ERK2 cascade|feeding behavior|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	cytoplasm|integral to membrane|nucleus|plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|protein binding|serotonin binding|serotonin receptor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(15)|ovary(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	50					Chlorprothixene(DB01239)|Clozapine(DB00363)|Dexfenfluramine(DB01191)|Fenfluramine(DB00574)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Olanzapine(DB00334)|Promazine(DB00420)|Propiomazine(DB00777)|Quetiapine(DB01224)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Tramadol(DB00193)|Ziprasidone(DB00246)	TGTATCAGTTCCTATCCCTGT	0.433000													31	14					0	0	1	0	0
TNNT3	7140	broad.mit.edu	37	11	1956113	1956113	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:1956113C>T	ENST00000381558.1	+	13	900	c.621C>T	c.(619-621)ttC>ttT	p.F207F	TNNT3_ENST00000381549.3_Silent_p.F207F|TNNT3_ENST00000397301.1_Silent_p.F226F|TNNT3_ENST00000381589.3_Silent_p.F213F|TNNT3_ENST00000397304.2_Silent_p.F196F|TNNT3_ENST00000381579.3_Silent_p.F207F|TNNT3_ENST00000381561.4_Silent_p.F218F|TNNT3_ENST00000360603.3_Silent_p.F209F|TNNT3_ENST00000381548.3_Silent_p.F217F|TNNT3_ENST00000278317.6_Silent_p.F215F|TNNT3_ENST00000493234.1_3'UTR|TNNT3_ENST00000446240.1_Silent_p.F196F			P45378	TNNT3_HUMAN	troponin T type 3 (skeletal, fast)	226					muscle filament sliding|regulation of ATPase activity|regulation of striated muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium-dependent protein binding|tropomyosin binding|troponin C binding|troponin I binding			breast(2)|endometrium(1)|kidney(1)|lung(8)|ovary(1)|prostate(1)|skin(4)|stomach(1)	19		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00253)|Lung(200;0.0333)|LUSC - Lung squamous cell carcinoma(625;0.0826)		TTGACAAGTTCGAGTTTGGGG	0.597000													99	138					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32011620	32011620	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:32011620G>A	ENST00000375244.3	-	35	11637	c.11436C>T	c.(11434-11436)ctC>ctT	p.L3812L	TNXB_ENST00000375247.2_Silent_p.L3810L|TNXB_ENST00000451343.1_Silent_p.L241L			P22105	TENX_HUMAN	tenascin XB	3857	Fibronectin type-III 30.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TCAGCCCCTGGAGTTTCTGGG	0.627000													61	135					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175048480	175048480	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:175048480C>T	ENST00000239462.4	+	3	534	c.421C>T	c.(421-423)Cac>Tac	p.H141Y		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	141					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TCTAAGCCGCCACTGCAGCGG	0.652000													5	20					0	0	1	0	0
LOC645752	645752	broad.mit.edu	37	15	78213778	78213778	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:78213778G>A	ENST00000565869.1	+	0	111				RP11-114H24.2_ENST00000567226.1_RNA																							CAGATCCTTGGACTCTTCTGT	0.547000													12	50					0	0	1	0	0
RELA	5970	broad.mit.edu	37	11	65425951	65425951	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:65425951G>A	ENST00000525693.1	-	8	746	c.684C>T	c.(682-684)ttC>ttT	p.F228F	RELA_ENST00000308639.9_Silent_p.F225F|RELA_ENST00000406246.3_Silent_p.F228F			Q04206	TF65_HUMAN	v-rel avian reticuloendotheliosis viral oncogene homolog A	228	RHD.				anti-apoptosis|cellular defense response|cytokine-mediated signaling pathway|defense response to virus|inflammatory response|innate immune response|interspecies interaction between organisms|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of inflammatory response|response to interleukin-1|response to UV-B|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|transcription factor complex	activating transcription factor binding|chromatin binding|identical protein binding|NF-kappaB binding|phosphate binding|protein kinase binding|protein N-terminus binding|repressing transcription factor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(11)|ovary(1)|urinary_tract(1)	19						CTGGTCCCGTGAAATACACCT	0.587000													23	34					0	0	1	0	0
BAZ2A	11176	broad.mit.edu	37	12	57009025	57009025	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:57009025G>A	ENST00000179765.5	-	3	702	c.503C>T	c.(502-504)tCc>tTc	p.S168F	BAZ2A_ENST00000551812.1_Missense_Mutation_p.S170F|BAZ2A_ENST00000549884.1_Missense_Mutation_p.S168F|BAZ2A_ENST00000379441.3_Missense_Mutation_p.S170F			Q9UIF9	BAZ2A_HUMAN	bromodomain adjacent to zinc finger domain, 2A	170					chromatin silencing at rDNA|DNA methylation|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	DNA binding|histone acetyl-lysine binding|ligand-dependent nuclear receptor binding|RNA binding|zinc ion binding			breast(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(15)|urinary_tract(1)	31						GTCAGGAAAGGAATCATACAG	0.478000													5	24					0	0	1	0	0
ZNF239	8187	broad.mit.edu	37	10	44052591	44052591	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:44052591G>A	ENST00000306006.6	-	2	1589	c.937C>T	c.(937-939)Cac>Tac	p.H313Y	ZNF239_ENST00000374446.2_Missense_Mutation_p.H313Y|ZNF239_ENST00000426961.1_Missense_Mutation_p.H313Y|ZNF239_ENST00000535642.1_Missense_Mutation_p.H313Y	NM_005674.2	NP_005665.2	Q16600	ZN239_HUMAN	zinc finger protein 239	313					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|RNA binding|zinc ion binding			endometrium(5)|large_intestine(5)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TCTCCAGTGTGGACTCGCTGG	0.522000													30	22					0	0	1	0	0
CEP63	80254	broad.mit.edu	37	3	134278111	134278111	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:134278111C>T	ENST00000337090.3	+	14	1966	c.1793C>T	c.(1792-1794)cCc>cTc	p.P598L	CEP63_ENST00000383229.3_Intron|CEP63_ENST00000354446.3_Intron|CEP63_ENST00000332047.5_Intron|CEP63_ENST00000606977.1_Missense_Mutation_p.P598L|CEP63_ENST00000513612.2_Missense_Mutation_p.P598L			Q96MT8	CEP63_HUMAN	centrosomal protein 63kDa	598					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(4)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27						GTGCTAAGCCCCCTGAGTCCT	0.448000													68	93					0	0	1	0	0
CADM4	199731	broad.mit.edu	37	19	44130381	44130381	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:44130381G>A	ENST00000222374.2	-	5	607	c.559C>T	c.(559-561)Cgt>Tgt	p.R187C		NM_145296.1	NP_660339.1	Q8NFZ8	CADM4_HUMAN	cell adhesion molecule 4	187	Ig-like C2-type 1.				cell adhesion	integral to membrane				endometrium(2)|large_intestine(3)|lung(4)|prostate(1)|skin(2)	12		Prostate(69;0.0199)				CGGTCCACACGAAACCGTACT	0.597000													14	17					0	0	1	0	0
MUC3A	4584	broad.mit.edu	37	7	100549815	100549815	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:100549815G>A	ENST00000379458.4	+	2	396	c.396G>A	c.(394-396)acG>acA	p.132_132insT	MUC3A_ENST00000483366.1_3'UTR					mucin 3A, cell surface associated											breast(3)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(1)|lung(32)|prostate(3)	44						TGTATCCAACGAGCTTTATAA	0.552000													13	89					0	0	1	0	0
COL4A1	1282	broad.mit.edu	37	13	110835395	110835395	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:110835395C>T	ENST00000375820.4	-	28	2161	c.2040G>A	c.(2038-2040)gaG>gaA	p.E680E		NM_001845.4	NP_001836.2	P02462	CO4A1_HUMAN	collagen, type IV, alpha 1	680	Triple-helical region.				angiogenesis|axon guidance		extracellular matrix structural constituent|platelet-derived growth factor binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	105	all_cancers(4;9.8e-13)|all_epithelial(4;9.66e-08)|all_lung(23;3.75e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00178)|all_neural(89;0.00459)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0604)	Breast(118;0.2)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.145)			CAGCGCCCTTCTCTCCTGGCA	0.612000													23	12					0	0	1	0	0
CDH18	1016	broad.mit.edu	37	5	19721525	19721525	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:19721525C>T	ENST00000507958.1	-	7	1564	c.574G>A	c.(574-576)Gga>Aga	p.G192R	CDH18_ENST00000502796.1_Missense_Mutation_p.G192R|CDH18_ENST00000382275.1_Missense_Mutation_p.G192R|CDH18_ENST00000511273.1_Missense_Mutation_p.G192R|CDH18_ENST00000506372.1_Missense_Mutation_p.G192R|CDH18_ENST00000274170.4_Missense_Mutation_p.G192R			Q13634	CAD18_HUMAN	cadherin 18, type 2	192	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					GCGCTGTTTCCATAGGTAGGG	0.453000													19	18					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128341776	128341776	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:128341776G>A	ENST00000389524.4	+	13	1476	c.1423G>A	c.(1423-1425)Gag>Aag	p.E475K	MYO7B_ENST00000409816.2_Missense_Mutation_p.E475K|MYO7B_ENST00000428314.1_Missense_Mutation_p.E475K			Q6PIF6	MYO7B_HUMAN	myosin VIIB	475	Myosin head-like.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		CATGGAGCAAGAGGAGTACCG	0.572000													16	35					0	0	1	0	0
INTS5	80789	broad.mit.edu	37	11	62416553	62416553	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:62416553G>A	ENST00000330574.2	-	2	1051	c.999C>T	c.(997-999)tcC>tcT	p.S333S		NM_030628.1	NP_085131.1	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	333					snRNA processing	integral to membrane|integrator complex	protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	36						TGGCCTGAAGGGAGGGGTCCC	0.627000													32	134					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70504260	70504260	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:70504260A>T	ENST00000310961.5	+	22	3072	c.2654A>T	c.(2653-2655)gAa>gTa	p.E885V	LRRC7_ENST00000035383.5_Missense_Mutation_p.E880V|LRRC7_ENST00000415775.2_Missense_Mutation_p.E164V			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	880						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						CATATAAAGGAATCTACTGAA	0.438000													16	114					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3240559	3240559	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:3240559A>T	ENST00000217939.6	-	5	3321	c.3167T>A	c.(3166-3168)aTt>aAt	p.I1056N		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1056						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				ACCCTTTTTAATCAGTAAGGT	0.473000													45	6					0	0	1	0	0
OR51L1	119682	broad.mit.edu	37	11	5020744	5020744	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:5020744C>T	ENST00000321543.1	+	1	532	c.532C>T	c.(532-534)Cac>Tac	p.H178Y		NM_001004755.1	NP_001004755.1	Q8NGJ5	O51L1_HUMAN	olfactory receptor, family 51, subfamily L, member 1	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(19)|skin(2)|stomach(1)	31		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.75e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCCCTCTCTCACGCCTTCTG	0.468000													46	76					0	0	1	0	0
ITGB5	3693	broad.mit.edu	37	3	124567295	124567295	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:124567295G>A	ENST00000296181.4	-	4	768	c.472C>T	c.(472-474)Cgg>Tgg	p.R158W	ITGB5_ENST00000488466.1_5'UTR	NM_002213.3	NP_002204.2	P18084	ITB5_HUMAN	integrin, beta 5	158	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	30				GBM - Glioblastoma multiforme(114;0.163)		CCCAGGCTCCGGATATTGTCC	0.532000													59	54					0	0	1	0	0
MYBPC1	4604	broad.mit.edu	37	12	102043044	102043044	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:102043044G>A	ENST00000549145.1	+	14	1267	c.1167G>A	c.(1165-1167)aaG>aaA	p.K389K	MYBPC1_ENST00000547405.1_Silent_p.K350K|MYBPC1_ENST00000553190.1_Silent_p.K376K|MYBPC1_ENST00000547509.1_Silent_p.K362K|MYBPC1_ENST00000551300.1_Silent_p.K277K|MYBPC1_ENST00000550501.1_Intron|MYBPC1_ENST00000361466.2_Silent_p.K401K|MYBPC1_ENST00000392934.3_Silent_p.K363K|MYBPC1_ENST00000550270.1_Silent_p.K376K|RP11-755O11.2_ENST00000552081.1_RNA|RP11-755O11.2_ENST00000547027.1_RNA|MYBPC1_ENST00000536007.1_Silent_p.K357K|MYBPC1_ENST00000441232.1_Silent_p.K376K|MYBPC1_ENST00000360610.2_Silent_p.K376K|MYBPC1_ENST00000541119.1_Silent_p.K364K|MYBPC1_ENST00000545503.2_Silent_p.K376K|MYBPC1_ENST00000452455.2_Silent_p.K376K|MYBPC1_ENST00000361685.2_Silent_p.K401K			Q00872	MYPC1_HUMAN	myosin binding protein C, slow type	376	Ig-like C2-type 3.				cell adhesion|muscle filament sliding	cytosol|myofibril|myosin filament	actin binding|structural constituent of muscle|titin binding	p.K376N(1)|p.K401N(1)		breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	57						TCAGGTTTAAGAATGGTGAAG	0.343000													5	26					0	0	1	0	0
TRBV4-2	28616	broad.mit.edu	37	7	142045592	142045592	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:142045592G>A	ENST00000390392.3	+	0	231																											AGAAGTCTTTGAAATGTGAAC	0.453000													44	146					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	233995348	233995348	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:233995348G>A	ENST00000359570.5	+	5	655	c.655G>A	c.(655-657)Gag>Aag	p.E219K	INPP5D_ENST00000538935.1_Missense_Mutation_p.E219K|INPP5D_ENST00000474278.1_3'UTR			Q92835	SHIP1_HUMAN	inositol polyphosphate-5-phosphatase, 145kDa	219					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GCTCTGCAAGGAGCTCTATGG	0.577000													15	18					0	0	1	0	0
GABARAPL3	23766	broad.mit.edu	37	15	90892258	90892258	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:90892258C>T	ENST00000412799.2	-	1	411	c.172G>A	c.(172-174)Ggc>Agc	p.G58S																								TAGAACTGGCCATCGGTAAGG	0.507000													12	10					0	0	1	0	0
SBSPON	157869	broad.mit.edu	37	8	73993428	73993428	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:73993428C>T	ENST00000297354.6	-	2	439	c.235G>A	c.(235-237)Gaa>Aaa	p.E79K	SBSPON_ENST00000519697.1_5'UTR	NM_153225.3	NP_694957.3	Q8IVN8	RPESP_HUMAN	somatomedin B and thrombospondin, type 1 domain containing	79	TSP type-1.				immune response	extracellular region	polysaccharide binding|scavenger receptor activity										GGGCTCCATTCCCCCACGAAG	0.632000													34	52					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870558	51870558	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:51870558G>A	ENST00000371497.5	+	2	1448	c.561G>A	c.(559-561)tcG>tcA	p.S187S	TSHZ2_ENST00000603338.2_Silent_p.S184S|TSHZ2_ENST00000329613.6_Silent_p.S184S	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	187					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			GGTCCGTCTCGAAACCCAGCC	0.557000													24	46					0	0	1	0	0
ANO3	63982	broad.mit.edu	37	11	26484631	26484631	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:26484631G>A	ENST00000256737.3	+	4	1220	c.368G>A	c.(367-369)cGa>cAa	p.R123Q	ANO3_ENST00000531646.1_Missense_Mutation_p.R123Q|ANO3_ENST00000537978.1_Missense_Mutation_p.R107Q|ANO3_ENST00000525139.1_Missense_Mutation_p.R107Q	NM_031418.2	NP_113606.2	Q9BYT9	ANO3_HUMAN	anoctamin 3	123						chloride channel complex	chloride channel activity			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	68						ACTTATGACCGATCTCGTCTC	0.299000													8	19					0	0	1	0	0
NUTM1	256646	broad.mit.edu	37	15	34646853	34646853	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:34646853G>A	ENST00000537011.1	+	6	1664	c.1282G>A	c.(1282-1284)Gag>Aag	p.E428K	NUTM1_ENST00000333756.4_Missense_Mutation_p.E400K|NUTM1_ENST00000438749.3_Missense_Mutation_p.E418K					NUT midline carcinoma, family member 1																		GCAGCAGCAGGAGGAGGAAGG	0.527000													51	62					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703095	4703095	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:4703095G>A	ENST00000396950.3	-	2	1086	c.847C>T	c.(847-849)Cct>Tct	p.P283S		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	283					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		ATGACAGGAGGCAGCAGCAGG	0.502000													18	40					0	0	1	0	0
ZDHHC3	51304	broad.mit.edu	37	3	45000782	45000782	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:45000782G>A	ENST00000296127.3	-	2	420	c.147C>T	c.(145-147)atC>atT	p.I49I	ZDHHC3_ENST00000424952.2_Silent_p.I49I|ZDHHC3_ENST00000342790.4_Silent_p.I49I	NM_016598.2	NP_057682.1	Q9NYG2	ZDHC3_HUMAN	zinc finger, DHHC-type containing 3	49						Golgi membrane|integral to membrane	zinc ion binding			endometrium(1)|large_intestine(3)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(193;0.00943)|KIRC - Kidney renal clear cell carcinoma(197;0.053)|Kidney(197;0.0665)		ACCAGGTAACGATGGCACAGG	0.532000													57	81					0	0	1	0	0
HECTD4	283450	broad.mit.edu	37	12	112650372	112650372	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:112650372G>A	ENST00000550722.1	-	49	7505	c.7110C>T	c.(7108-7110)ttC>ttT	p.F2370F	HECTD4_ENST00000430131.2_Silent_p.F2094F|HECTD4_ENST00000377560.5_Silent_p.F2344F	NM_001109662.3	NP_001103132.3			HECT domain containing E3 ubiquitin protein ligase 4																		CGCAGTATGTGAAGTACACCC	0.567000													22	58					0	0	1	0	0
OR5H1	26341	broad.mit.edu	37	3	97851871	97851871	+	Silent	SNP	G	G	A	rs113686881		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:97851871G>A	ENST00000354565.2	+	1	330	c.330G>A	c.(328-330)acG>acA	p.T110T	RP11-343D2.11_ENST00000508964.1_RNA	NM_001005338.1	NP_001005338.1	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H, member 1	110					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|kidney(8)|large_intestine(3)|lung(13)|ovary(1)|skin(1)	34						GTGTAACCACGGAATGTTTTC	0.408000													54	95					0	0	1	0	0
KHDC3L	154288	broad.mit.edu	37	6	74073511	74073511	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:74073511C>T	ENST00000370367.3	+	3	635	c.582C>T	c.(580-582)tcC>tcT	p.S194S		NM_001017361.2	NP_001017361.1			KH domain containing 3-like, subcortical maternal complex member																		CCCAGCGATCCCCCGAAGCTG	0.642000													9	53					0	0	1	0	0
SOHLH2	54937	broad.mit.edu	37	13	36767801	36767801	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:36767801C>A	ENST00000379881.3	-	4	475	c.387G>T	c.(385-387)atG>atT	p.M129I	CCDC169-SOHLH2_ENST00000511166.1_Missense_Mutation_p.M206I|SOHLH2_ENST00000317764.6_Missense_Mutation_p.M129I|SOHLH2_ENST00000554962.1_Missense_Mutation_p.M206I	NM_017826.2	NP_060296.2			spermatogenesis and oogenesis specific basic helix-loop-helix 2											autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(13)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.184)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;4.63e-08)|Epithelial(112;2.67e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00272)|BRCA - Breast invasive adenocarcinoma(63;0.00685)|GBM - Glioblastoma multiforme(144;0.0273)		CCACATTACTCATTTTTTCCA	0.308000													19	53					3.8784e-16	3.92304e-16	1	1	0
EMB	133418	broad.mit.edu	37	5	49707048	49707048	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:49707048G>A	ENST00000303221.5	-	3	581	c.366C>T	c.(364-366)acC>acT	p.T122T	EMB_ENST00000508934.1_Silent_p.T68T|EMB_ENST00000514111.1_Silent_p.T72T|EMB_ENST00000506190.1_5'UTR	NM_198449.2	NP_940851.1	Q6PCB8	EMB_HUMAN	embigin	122	Ig-like V-type 1.					integral to membrane				breast(2)|endometrium(3)|large_intestine(4)|lung(4)|skin(2)	15	Lung SC(58;0.218)	Lung NSC(810;0.0795)				GGGTATACAAGGTGCTTCCTG	0.363000													26	30					0	0	1	0	0
ARHGAP44	9912	broad.mit.edu	37	17	12888210	12888210	+	Missense_Mutation	SNP	G	G	A	rs77850388		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:12888210G>A	ENST00000379672.5	+	20	2602	c.2302G>A	c.(2302-2304)Gaa>Aaa	p.E768K	ARHGAP44_ENST00000340825.3_Missense_Mutation_p.E762K|ARHGAP44_ENST00000262444.9_Missense_Mutation_p.E768K	NM_014859.4	NP_055674.4	Q17R89	RHG44_HUMAN	Rho GTPase activating protein 44	768					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|urinary_tract(1)	31						GTCCCCTGGGGAAAGCATGTC	0.542000													21	13					0	0	1	0	0
ANKEF1	63926	broad.mit.edu	37	20	10036272	10036272	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:10036272G>A	ENST00000378380.3	+	10	2624	c.2295G>A	c.(2293-2295)gaG>gaA	p.E765E	SNAP25-AS1_ENST00000421143.2_RNA|ANKEF1_ENST00000378392.1_Silent_p.E765E|ANKEF1_ENST00000488991.1_3'UTR|SNAP25-AS1_ENST00000603542.1_RNA	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		ACATCACAGAGAAAGCTCGAG	0.468000													17	37					0	0	1	0	0
FAT2	2196	broad.mit.edu	37	5	150946444	150946444	+	Silent	SNP	G	G	A	rs142348925	byFrequency	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:150946444G>A	ENST00000261800.5	-	1	2061	c.2049C>T	c.(2047-2049)atC>atT	p.I683I		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	683					epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TAAAGTGGAGGATAGTCTTTG	0.408000													23	38					0	0	1	0	0
PDCD11	22984	broad.mit.edu	37	10	105177554	105177554	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:105177554G>A	ENST00000369797.3	+	14	1870	c.1776G>A	c.(1774-1776)gtG>gtA	p.V592V		NM_014976.1	NP_055791.1	Q14690	RRP5_HUMAN	programmed cell death 11	592	S1 motif 6.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|lung(29)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	64		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		GCCAGGTGGTGAAGGTTGTCG	0.547000													36	24					0	0	1	0	0
PILRB	29990	broad.mit.edu	37	7	99956508	99956508	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:99956508C>T	ENST00000310771.4	+	16	2756	c.260C>T	c.(259-261)cCt>cTt	p.P87L	PILRB_ENST00000444874.1_Intron|PILRB_ENST00000444073.1_Missense_Mutation_p.P87L|PILRB_ENST00000452089.1_Missense_Mutation_p.P87L|PILRB_ENST00000448382.1_Intron			Q9UKJ0	PILRB_HUMAN	paired immunoglobin-like type 2 receptor beta	87	Ig-like V-type.				activation of transmembrane receptor protein tyrosine kinase activity	integral to plasma membrane	protein binding|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	13	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ACAAGGCCGCCTTCCATTCAC	0.547000													8	118					0	0	1	0	0
ZNF354B	117608	broad.mit.edu	37	5	178310306	178310306	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:178310306C>T	ENST00000322434.3	+	5	1079	c.853C>T	c.(853-855)Ctt>Ttt	p.L285F		NM_058230.2	NP_478137.1	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	285					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|liver(2)|lung(2)|ovary(2)|stomach(3)|urinary_tract(1)	21	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TAGTGCATCCCTTTGTAAGCA	0.388000													25	32					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179407270	179407270	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179407270C>T	ENST00000589042.1	-	349	97437	c.97213G>A	c.(97213-97215)Gga>Aga	p.G32405R	TTN_ENST00000342992.6_Missense_Mutation_p.G29837R|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G30764R|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G23340R|TTN_ENST00000342175.6_Missense_Mutation_p.G23532R|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G23465R|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30764	Protein kinase.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTAATAGGTCCTGTTGGTGGA	0.393000													19	20					0	0	1	0	0
WDR16	146845	broad.mit.edu	37	17	9536284	9536284	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:9536284C>T	ENST00000352665.5	+	10	1323	c.1254C>T	c.(1252-1254)atC>atT	p.I418I	WDR16_ENST00000576714.1_3'UTR|WDR16_ENST00000299764.5_Silent_p.I428I|WDR16_ENST00000396219.3_Silent_p.I350I	NM_145054.4	NP_659491.4	Q8N1V2	WDR16_HUMAN	WD repeat domain 16	418						cytoplasm|intracellular membrane-bounded organelle	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31						CTCACAGGATCGGCGTCACCG	0.507000													29	12					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153897471	153897471	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:153897471C>T	ENST00000511601.1	+	12	3216	c.3028C>T	c.(3028-3030)Cct>Tct	p.P1010S	FHDC1_ENST00000260008.3_Missense_Mutation_p.P1010S			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	1010					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					CTCCGAGGGCCCTGAGAGTCC	0.622000													51	45					0	0	1	0	0
RHPN1	114822	broad.mit.edu	37	8	144464756	144464756	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:144464756C>T	ENST00000289013.6	+	15	2049	c.1948C>T	c.(1948-1950)Ccc>Tcc	p.P650S		NM_052924.2	NP_443156.2	Q8TCX5	RHPN1_HUMAN	rhophilin, Rho GTPase binding protein 1	675					signal transduction	intracellular				endometrium(1)|large_intestine(1)|lung(7)	9	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			TGGAGGCTGCCCCCAGCCCTG	0.692000													16	22					0	0	1	0	0
ZNF133	7692	broad.mit.edu	37	20	18296625	18296625	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:18296625C>A	ENST00000377671.3	+	7	1686	c.1127C>A	c.(1126-1128)tCt>tAt	p.S376Y	ZNF133_ENST00000462170.1_3'UTR|ZNF133_ENST00000535822.1_Missense_Mutation_p.S282Y|ZNF133_ENST00000396026.3_Missense_Mutation_p.S380Y|ZNF133_ENST00000401790.1_Missense_Mutation_p.S377Y|ZNF133_ENST00000316358.4_Missense_Mutation_p.S377Y|ZNF133_ENST00000402618.2_Missense_Mutation_p.S314Y|ZNF133_ENST00000538547.1_Missense_Mutation_p.S282Y	NM_001083330.1|NM_003434.4	NP_001076799.1|NP_003425.2	P52736	ZN133_HUMAN	zinc finger protein 133	377						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	26						AGGACGCACTCTGGGGAGAAG	0.582000													22	39					8.10497e-08	8.15135e-08	1	1	0
MIR325	442899	broad.mit.edu	37	X	76225911	76225911	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:76225911G>A	ENST00000385260.1	-	0	15					NR_029905.1																						cacctactaggaaccaagcac	0.383000													37	7					0	0	1	0	0
ALG11	440138	broad.mit.edu	37	13	52598464	52598464	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:52598464C>T	ENST00000521508.1	+	3	603	c.598C>T	c.(598-600)Cct>Tct	p.P200S	ALG11_ENST00000519151.1_3'UTR|ALG11_ENST00000523764.1_Intron	NM_001004127.2	NP_001004127.2			ALG11, alpha-1,2-mannosyltransferase											endometrium(1)|large_intestine(6)|lung(4)|ovary(2)	13		Breast(56;0.00173)|Lung NSC(96;0.0108)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;2.44e-08)		TGTTCATTATCCTACTATCAG	0.383000													57	61					0	0	1	0	0
GIMAP1	170575	broad.mit.edu	37	7	150417903	150417903	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:150417903C>T	ENST00000307194.5	+	3	951	c.811C>T	c.(811-813)Ccc>Tcc	p.P271S		NM_130759.3	NP_570115.1			GTPase, IMAP family member 1											NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	28			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GCTGAAGTCCCCCAGGAGCTG	0.746000													7	11					0	0	1	0	0
SCN7A	6332	broad.mit.edu	37	2	167263129	167263129	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:167263129G>A	ENST00000409855.1	-	25	4136	c.4010C>T	c.(4009-4011)tCc>tTc	p.S1337F		NM_002976.3	NP_002967.2	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha subunit	1337					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						CACAAGGTAGGATCCTACTGT	0.408000													32	69					0	0	1	0	0
SPATA31A6	389730	broad.mit.edu	37	9	43627122	43627122	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:43627122G>A	ENST00000332857.6	-	4	1593	c.1565C>T	c.(1564-1566)cCt>cTt	p.P522L		NM_001145196.1	NP_001138668.1			SPATA31 subfamily A, member 6																		CTGCGATGCAGGGCAAGCTAC	0.507000													155	247					0	0	1	0	0
TMEM98	26022	broad.mit.edu	37	17	31266526	31266526	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:31266526C>T	ENST00000579849.1	+	7	876	c.445C>T	c.(445-447)Ccg>Tcg	p.P149S	TMEM98_ENST00000578289.1_Intron|TMEM98_ENST00000394642.3_Missense_Mutation_p.P149S	NM_015544.2	NP_056359.2	Q9Y2Y6	TMM98_HUMAN	transmembrane protein 98	149						endoplasmic reticulum|integral to membrane				kidney(2)|large_intestine(1)	3		Ovarian(249;0.182)|Breast(31;0.244)	BRCA - Breast invasive adenocarcinoma(9;0.0769)			GATGTACCCTCCGTTGGACCC	0.493000													17	31					0	0	1	0	0
RYR3	6263	broad.mit.edu	37	15	34042431	34042431	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:34042431G>A	ENST00000389232.4	+	57	8413	c.8343G>A	c.(8341-8343)cgG>cgA	p.R2781R	RYR3_ENST00000415757.3_Silent_p.R2781R	NM_001036.3	NP_001027.3	Q15413	RYR3_HUMAN	ryanodine receptor 3	2781	4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(3)|breast(9)|central_nervous_system(8)|cervix(2)|endometrium(29)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(55)|lung(148)|ovary(7)|pancreas(1)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(3)	311		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCAAGGACCGGGAGAAGGCAC	0.517000													3	7					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96522574	96522574	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:96522574G>A	ENST00000371321.3	+	1	194	c.112G>A	c.(112-114)Gtg>Atg	p.V38M	CYP2C19_ENST00000464755.1_Intron	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	38					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	TCCTCTCCCAGTGATTGGAAA	0.443000													5	52					0	0	1	0	0
DPY19L3	147991	broad.mit.edu	37	19	32944126	32944126	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:32944126C>T	ENST00000342179.5	+	9	1146	c.931C>T	c.(931-933)Ctt>Ttt	p.L311F	DPY19L3_ENST00000392250.2_Missense_Mutation_p.L311F|DPY19L3_ENST00000586987.1_Missense_Mutation_p.L311F	NM_207325.2	NP_997208.2	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3 (C. elegans)	311						integral to membrane				breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(4)|pancreas(1)	32	Esophageal squamous(110;0.162)					TTCCATGATTCTTGGATCACT	0.338000													11	24					0	0	1	0	0
CCDC77	84318	broad.mit.edu	37	12	547701	547701	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:547701C>T	ENST00000239830.4	+	10	1201	c.1022C>T	c.(1021-1023)gCt>gTt	p.A341V	CCDC77_ENST00000540180.1_Missense_Mutation_p.A309V|CCDC77_ENST00000412006.2_Missense_Mutation_p.A309V|CCDC77_ENST00000422000.1_Missense_Mutation_p.A309V	NM_032358.3	NP_115734.1	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77	341						centrosome				cervix(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			AGTCACCATGCTCAAAGTGAA	0.343000													37	20					0	0	1	0	0
STK11IP	114790	broad.mit.edu	37	2	220470753	220470753	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:220470753C>T	ENST00000456909.1	+	9	911	c.821C>T	c.(820-822)cCa>cTa	p.P274L	STK11IP_ENST00000295641.10_Missense_Mutation_p.P285L|STK11IP_ENST00000459692.1_3'UTR			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	285					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GAGCTGTCACCACTGTGGCTG	0.607000											OREG0003992	type=REGULATORY REGION|Gene=STK11IP|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	6	9					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36874626	36874626	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:36874626C>T	ENST00000301807.6	-	21	6563	c.4666G>A	c.(4666-4668)Gag>Aag	p.E1556K	TRANK1_ENST00000428977.2_Missense_Mutation_p.E1556K|TRANK1_ENST00000429976.2_Missense_Mutation_p.E2106K	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2106					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GTTTTTTTCTCTCTCAAGTTC	0.408000													7	10					0	0	1	0	0
PGAP1	80055	broad.mit.edu	37	2	197708730	197708730	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:197708730G>A	ENST00000354764.3	-	25	2521	c.2407C>T	c.(2407-2409)Cgt>Tgt	p.R803C		NM_024989.3	NP_079265.2	Q75T13	PGAP1_HUMAN	post-GPI attachment to proteins 1	803					attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			breast(4)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|ovary(6)|stomach(1)|urinary_tract(1)	40						GCAGATAAACGAAGATGGTGT	0.353000													8	16					0	0	1	0	0
SCARA5	286133	broad.mit.edu	37	8	27845079	27845079	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:27845079G>A	ENST00000354914.3	-	2	539	c.54C>T	c.(52-54)tcC>tcT	p.S18S	SCARA5_ENST00000524352.1_Silent_p.S18S|SCARA5_ENST00000518030.1_Silent_p.S18S|SCARA5_ENST00000380385.2_Silent_p.S18S|SCARA5_ENST00000301906.4_Silent_p.S18S	NM_173833.5	NP_776194.2	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5 (putative)	18					cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|large_intestine(6)|lung(5)|prostate(3)|skin(3)	18		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		CCTCACAGATGGAGCTGGTGT	0.557000													32	59					0	0	1	0	0
GFRA4	64096	broad.mit.edu	37	20	3640612	3640612	+	Missense_Mutation	SNP	C	C	T	rs141342254		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:3640612C>T	ENST00000290417.2	-	6	753	c.754G>A	c.(754-756)Gag>Aag	p.E252K	GFRA4_ENST00000319242.3_Missense_Mutation_p.E282K	NM_022139.3|NM_145762.2	NP_071422.1|NP_665705.1	Q9GZZ7	GFRA4_HUMAN	GDNF family receptor alpha 4	282						anchored to membrane|extracellular region|plasma membrane	receptor activity			large_intestine(1)|lung(2)	3						GAGCGTCTCTCCAGGGCCCTG	0.642000													5	1					0	0	1	0	0
SLC5A2	6524	broad.mit.edu	37	16	31498667	31498667	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:31498667G>A	ENST00000330498.3	+	6	620	c.601G>A	c.(601-603)Gac>Aac	p.D201N		NM_003041.3	NP_003032.1	P31639	SC5A2_HUMAN	solute carrier family 5 (sodium/glucose cotransporter), member 2	201					carbohydrate metabolic process	integral to membrane	low-affinity glucose:sodium symporter activity			endometrium(2)|kidney(3)|large_intestine(5)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	25						GATGTACACGGACACGGTACA	0.637000													113	199					0	0	1	0	0
POF1B	79983	broad.mit.edu	37	X	84606374	84606374	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:84606374C>T	ENST00000262753.4	-	5	667	c.522G>A	c.(520-522)gaG>gaA	p.E174E	POF1B_ENST00000373145.3_Silent_p.E174E	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	174							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						TATTTAGCTTCTCCACTTTTC	0.284000													12	3					0	0	1	0	0
MYBPH	4608	broad.mit.edu	37	1	203138109	203138109	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:203138109C>T	ENST00000255416.4	-	9	1399	c.1342G>A	c.(1342-1344)Gat>Aat	p.D448N		NM_004997.2	NP_004988.2	Q13203	MYBPH_HUMAN	myosin binding protein H	448	Ig-like C2-type 2.				cell adhesion|regulation of striated muscle contraction	myosin filament	structural constituent of muscle			endometrium(5)|large_intestine(6)|lung(7)|skin(1)|urinary_tract(1)	20			BRCA - Breast invasive adenocarcinoma(75;0.153)	Colorectal(1306;0.0306)		ACCCCAGAATCAAAGGGGCTG	0.562000													191	78					0	0	1	0	0
ACKR2	1238	broad.mit.edu	37	3	42906351	42906351	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:42906351G>A	ENST00000422265.1	+	3	532	c.357G>A	c.(355-357)atG>atA	p.M119I	ACKR2_ENST00000471537.1_Intron|CYP8B1_ENST00000437102.1_Intron|ACKR2_ENST00000273145.2_Missense_Mutation_p.M119I|ACKR2_ENST00000442925.1_Missense_Mutation_p.M119I|KRBOX1_ENST00000426937.1_Intron	NM_001296.4	NP_001287.2			atypical chemokine receptor 2																		TGTGCAAGATGGTGAGCACTC	0.493000													56	95					0	0	1	0	0
UFD1L	7353	broad.mit.edu	37	22	19463094	19463094	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:19463094G>A	ENST00000263202.9	-	2	164	c.35C>T	c.(34-36)cCc>cTc	p.P12L	UFD1L_ENST00000484101.1_5'UTR|UFD1L_ENST00000360834.4_Missense_Mutation_p.P12L|UFD1L_ENST00000399523.1_Missense_Mutation_p.P12L	NM_001035247.2|NM_005659.6	NP_001030324.2|NP_005650.2	Q92890	UFD1_HUMAN	ubiquitin fusion degradation 1 like (yeast)	12					skeletal system development|ubiquitin-dependent protein catabolic process	cytosol|nucleus	protein binding|ubiquitin-specific protease activity			large_intestine(3)|upper_aerodigestive_tract(1)	4	Colorectal(54;0.0993)					GAAGACCCTGGGAATAGGGTG	0.453000													29	41					0	0	1	0	0
DYDC2	84332	broad.mit.edu	37	10	82126699	82126699	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:82126699C>T	ENST00000372199.1	+	6	1124	c.526C>T	c.(526-528)Cct>Tct	p.P176S	DYDC2_ENST00000444807.2_Missense_Mutation_p.P176S|DYDC2_ENST00000372197.1_Missense_Mutation_p.P176S|DYDC2_ENST00000256039.2_Missense_Mutation_p.P176S|DYDC2_ENST00000372198.1_Missense_Mutation_p.P190S			Q96IM9	DYDC2_HUMAN	DPY30 domain containing 2	176							protein binding			breast(1)|large_intestine(3)|lung(6)|skin(1)	11			Colorectal(32;0.229)			CTCCAAATCTCCTTTTTAGGT	0.408000													58	26					0	0	1	0	0
PAX4	5078	broad.mit.edu	37	7	127253091	127253091	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:127253091C>T	ENST00000341640.2	-	6	881	c.676G>A	c.(676-678)Gaa>Aaa	p.E226K	PAX4_ENST00000378740.2_Missense_Mutation_p.E226K|PAX4_ENST00000338516.3_Missense_Mutation_p.E234K|PAX4_ENST00000463946.1_Missense_Mutation_p.E224K	NM_006193.2	NP_006184.2	O43316	PAX4_HUMAN	paired box 4	234					cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|kidney(2)|large_intestine(6)|lung(20)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						AGCTGCATTTCCCACTTGAGC	0.522000													11	36					0	0	1	0	0
PKD1L1	168507	broad.mit.edu	37	7	47925508	47925508	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:47925508G>A	ENST00000289672.2	-	18	3031	c.2981C>T	c.(2980-2982)cCc>cTc	p.P994L		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	994	REJ.				cell-cell adhesion	integral to membrane		p.P994L(1)	BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						AAGGGTCACGGGTGAAGGTTC	0.582000													25	100					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103269903	103269903	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:103269903C>T	ENST00000520539.1	-	58	8750	c.8144G>A	c.(8143-8145)tGg>tAg	p.W2715*	UBR5_ENST00000220959.4_Nonsense_Mutation_p.W2714*|UBR5_ENST00000518205.1_Nonsense_Mutation_p.W443*|UBR5_ENST00000521922.1_Nonsense_Mutation_p.W2708*|KB-431C1.5_ENST00000606361.1_RNA	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	2715	HECT.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TACTATTGACCAGAACCAACG	0.323000													9	9					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152281703	152281703	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:152281703C>T	ENST00000368799.1	-	3	5694	c.5659G>A	c.(5659-5661)Gaa>Aaa	p.E1887K	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1887	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGGAAGCTTCATGGTGACGC	0.577000									Ichthyosis				355	198					0	0	1	0	0
RGS11	8786	broad.mit.edu	37	16	319584	319584	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:319584C>T	ENST00000397770.3	-	16	1224	c.1206_splice	c.e16-1	p.D403_splice	RGS11_ENST00000316163.5_Splice_Site_p.D382_splice|ARHGDIG_ENST00000464609.1_Intron|ITFG3_ENST00000600536.1_3'UTR|ITFG3_ENST00000442458.2_3'UTR|RGS11_ENST00000359740.5_Splice_Site_p.D392_splice			O94810	RGS11_HUMAN	regulator of G-protein signaling 11	403	RGS.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			endometrium(1)|kidney(1)|lung(4)|ovary(1)|pancreas(1)	8		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				GGGTAGGAGTCCTACAAGAGA	0.612000													16	37					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145393542	145393542	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:145393542C>T	ENST00000511217.1	+	4	1029	c.977C>T	c.(976-978)cCa>cTa	p.P326L	SH3RF2_ENST00000359120.4_Missense_Mutation_p.P326L			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	326							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATCAGCACCCCAGTGCTCATC	0.557000													38	96					0	0	1	0	0
GRM7	2917	broad.mit.edu	37	3	7620325	7620325	+	Missense_Mutation	SNP	G	G	A	rs138514405		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:7620325G>A	ENST00000486284.1	+	8	2006	c.1732G>A	c.(1732-1734)Gat>Aat	p.D578N	GRM7_ENST00000389336.4_Missense_Mutation_p.D578N|GRM7_ENST00000402647.2_Missense_Mutation_p.D578N|GRM7_ENST00000403881.1_Missense_Mutation_p.D578N|GRM7_ENST00000357716.4_Missense_Mutation_p.D578N|GRM7_ENST00000458641.2_3'UTR	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	578					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	CGGATGCCAGGATATTCCCAT	0.522000													44	74					0	0	1	0	0
EDNRB	1910	broad.mit.edu	37	13	78474052	78474052	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:78474052G>A	ENST00000377211.4	-	7	1558	c.1406C>T	c.(1405-1407)tCc>tTc	p.S469F	EDNRB_ENST00000446573.1_Missense_Mutation_p.S379F|EDNRB_ENST00000334286.5_Missense_Mutation_p.S379F	NM_001201397.1	NP_001188326.1	P24530	EDNRB_HUMAN	endothelin receptor type B	379					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(18)|lung(16)|skin(3)	42		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	GTTAATGCAGGAATTCAGTGA	0.348000													7	51					0	0	1	0	0
LRP4	4038	broad.mit.edu	37	11	46900826	46900826	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:46900826G>A	ENST00000378623.1	-	21	3097	c.2855C>T	c.(2854-2856)aCc>aTc	p.T952I		NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	952					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		TCCATAGAGGGTCAGCCCAAA	0.577000													32	49					0	0	1	0	0
PIK3CD	5293	broad.mit.edu	37	1	9781283	9781283	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:9781283C>T	ENST00000536656.1	+	14	2068	c.1860C>T	c.(1858-1860)gcC>gcT	p.A620A	PIK3CD_ENST00000377346.4_Silent_p.A596A|PIK3CD_ENST00000543390.1_Silent_p.A263A|PIK3CD_ENST00000361110.2_Silent_p.A620A			O00329	PK3CD_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	596					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		GCTCCTTCGCCATCAAGTCGC	0.647000													50	36					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28671027	28671027	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:28671027T>A	ENST00000280904.6	-	4	881	c.438A>T	c.(436-438)gaA>gaT	p.E146D	DSC2_ENST00000251081.6_Missense_Mutation_p.E146D	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	146	Cadherin 1.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			CCAAGGAGTTTTCTAGCATCG	0.413000													25	25					0	0	1	0	0
SNAP91	9892	broad.mit.edu	37	6	84311136	84311136	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:84311136G>A	ENST00000428679.2	-	16	1771	c.1178C>T	c.(1177-1179)tCt>tTt	p.S393F	SNAP91_ENST00000521743.1_Missense_Mutation_p.S393F|SNAP91_ENST00000521485.1_Missense_Mutation_p.S393F|SNAP91_ENST00000369694.2_Missense_Mutation_p.S393F|SNAP91_ENST00000195649.6_Missense_Mutation_p.S393F|SNAP91_ENST00000437520.1_Intron|SNAP91_ENST00000520213.1_Intron|SNAP91_ENST00000439399.2_Missense_Mutation_p.S393F|SNAP91_ENST00000520302.1_Missense_Mutation_p.S391F			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	393	Ala-rich.				clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		AGAGGGAACAGAGGAAAGTGC	0.448000													15	25					0	0	1	0	0
MYOCD	93649	broad.mit.edu	37	17	12626276	12626276	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:12626276G>A	ENST00000425538.1	+	5	566	c.366G>A	c.(364-366)gtG>gtA	p.V122V	MYOCD_ENST00000395988.1_Silent_p.V26V|MYOCD_ENST00000343344.4_Silent_p.V122V	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	122					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		TGGAGCTGGTGGAAAAAAACA	0.468000													60	32					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61687748	61687748	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:61687748C>T	ENST00000577390.1	-	12	3118	c.2164G>A	c.(2164-2166)Gat>Aat	p.D722N	CDH8_ENST00000299345.6_Intron|CDH8_ENST00000577730.1_Intron	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	722					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		ATAAATTCATCGACATCAACA	0.438000													30	48					0	0	1	0	0
LOC101929006	101929006	broad.mit.edu	37	6	29230563	29230563	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:29230563C>T	ENST00000441381.1	+	0	79																											GGACTGTTTCCTGGCTCTATA	0.433000													24	54					0	0	1	0	0
ANGPT4	51378	broad.mit.edu	37	20	858803	858803	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:858803C>T	ENST00000381922.3	-	7	1323		c.e7+1		ANGPT4_ENST00000546022.1_Splice_Site	NM_015985.2	NP_057069.1	Q9Y264	ANGP4_HUMAN	angiopoietin 4						anti-apoptosis|blood coagulation|cellular response to hypoxia|leukocyte migration|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of peptidyl-tyrosine phosphorylation|signal transduction	extracellular space	receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)	27						CCCGAACCCACCTGTATAGCT	0.622000													8	22					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91773462	91773462	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:91773462C>T	ENST00000389857.6	-	18	3201	c.3115G>A	c.(3115-3117)Gag>Aag	p.E1039K		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	1039					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				CCCCAGGCCTCCTTCCCCTGG	0.647000													35	10					0	0	1	0	0
ACTN1	87	broad.mit.edu	37	14	69347543	69347543	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:69347543G>A	ENST00000193403.6	-	17	2500	c.2117C>T	c.(2116-2118)aCc>aTc	p.T706I	ACTN1_ENST00000438964.2_Missense_Mutation_p.T706I|ACTN1_ENST00000538545.2_Missense_Mutation_p.T706I|ACTN1_ENST00000376839.3_Missense_Mutation_p.T641I|ACTN1_ENST00000394419.4_Missense_Mutation_p.T706I	NM_001102.3	NP_001093.1	P12814	ACTN1_HUMAN	actinin, alpha 1	706	Interaction with DDN.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(9)|prostate(2)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		GGTGTAGTTGGTGTGCTTGTT	0.572000													61	13					0	0	1	0	0
YDJC	150223	broad.mit.edu	37	22	21984272	21984272	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:21984272G>A	ENST00000292778.6	-	1	81	c.32C>T	c.(31-33)aCc>aTc	p.T11I	YDJC_ENST00000398873.3_Missense_Mutation_p.T11I	NM_001017964.1	NP_001017964.1	A8MPS7	YDJC_HUMAN	YdjC homolog (bacterial)	11					carbohydrate metabolic process		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds					Colorectal(54;0.105)					GTCGTCCGCGGTGACCACCAG	0.721000													3	36					0	0	1	0	0
NAA25	80018	broad.mit.edu	37	12	112528546	112528546	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:112528546G>A	ENST00000261745.4	-	3	515	c.267C>T	c.(265-267)taC>taT	p.Y89Y		NM_024953.3	NP_079229.2	Q14CX7	NAA25_HUMAN	N(alpha)-acetyltransferase 25, NatB auxiliary subunit	89						cytoplasm	protein binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(1)|lung(14)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(4)	46						GCATCTCCCGGTAAAGGATAG	0.438000													28	38					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	116931016	116931016	+	Silent	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:116931016T>C	ENST00000355044.3	+	8	1440	c.1314T>C	c.(1312-1314)taT>taC	p.Y438Y	ATRNL1_ENST00000529665.1_3'UTR|ATRNL1_ENST00000527407.1_3'UTR	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	438						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		CTGCAATATATGGTTATACAA	0.323000													5	46					0	0	1	0	0
TBX4	9496	broad.mit.edu	37	17	59560340	59560340	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:59560340C>T	ENST00000393853.4	+	9	1267	c.1104C>T	c.(1102-1104)ttC>ttT	p.F368F	TBX4_ENST00000589449.1_3'UTR|TBX4_ENST00000240335.1_Silent_p.F367F			P57082	TBX4_HUMAN	T-box 4	367					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(6)|liver(2)|lung(15)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						ATCACTATTTCCGTTCCCCCC	0.567000													14	21					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23896958	23896958	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:23896958G>A	ENST00000355349.3	-	16	1886	c.1724C>T	c.(1723-1725)gCc>gTc	p.A575V		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	575	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GGAGAAGTGGGCTTCAGGCTT	0.537000													41	15					0	0	1	0	0
ALK	238	broad.mit.edu	37	2	29606609	29606609	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:29606609T>C	ENST00000389048.3	-	5	2177	c.1271A>G	c.(1270-1272)aAc>aGc	p.N424S	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	424	MAM 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	TTCACTGCAGTTCTTCAGGGC	0.507000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				9	30					0	0	1	0	0
SNX32	254122	broad.mit.edu	37	11	65617689	65617689	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:65617689G>A	ENST00000308342.6	+	4	746	c.321G>A	c.(319-321)ggG>ggA	p.G107G		NM_152760.2	NP_689973.2	Q86XE0	SNX32_HUMAN	sorting nexin 32	107	PX.				cell communication|protein transport		phosphatidylinositol binding			endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20				READ - Rectum adenocarcinoma(159;0.171)		TGGGCGAGGGGGACAGCTCTG	0.597000													27	54					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61830330	61830330	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:61830330G>A	ENST00000280772.1	-	37	10500	c.10309C>T	c.(10309-10311)Caa>Taa	p.Q3437*	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3437					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TCCATGGCTTGAATTGGGAGT	0.448000													31	15					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29111072	29111072	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:29111072G>A	ENST00000261590.8	+	9	1346	c.1137G>A	c.(1135-1137)gtG>gtA	p.V379V		NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	379	Cadherin 3.				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			AGGTCAAAGTGAAAAATGTGA	0.368000													33	71					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43484873	43484873	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:43484873C>T	ENST00000395891.1	+	11	2707	c.2102C>T	c.(2101-2103)tCg>tTg	p.S701L	HECW1_ENST00000453890.1_Missense_Mutation_p.S701L	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	701	Cys-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						TACAGCGCCTCGTGCTACAGC	0.637000													29	59					0	0	1	0	0
PREX2	80243	broad.mit.edu	37	8	68934283	68934283	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:68934283C>T	ENST00000288368.4	+	4	626	c.349C>T	c.(349-351)Cgt>Tgt	p.R117C	PREX2_ENST00000529398.1_3'UTR	NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	117	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						AGACAAGTTTCGTATCTATGA	0.303000													12	22					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154134829	154134829	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:154134829G>A	ENST00000360256.4	-	15	5439	c.5239C>T	c.(5239-5241)Cct>Tct	p.P1747S		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1747	F5/8 type A 3.|Plastocyanin-like 5.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTGAACTGAGGGACACTGCCA	0.443000													30	9					0	0	1	0	0
TBC1D10C	374403	broad.mit.edu	37	11	67172938	67172938	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:67172938G>A	ENST00000312390.5	+	4	350	c.321G>A	c.(319-321)ggG>ggA	p.G107G	TBC1D10C_ENST00000526387.1_Silent_p.G107G|TBC1D10C_ENST00000542590.1_Silent_p.G107G	NM_198517.3	NP_940919.1	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	107	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			TGTTGTGTGGGGCCCATGTGT	0.642000													23	41					0	0	1	0	0
IRS4	8471	broad.mit.edu	37	X	107978058	107978058	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:107978058C>T	ENST00000372129.2	-	1	1593	c.1517G>A	c.(1516-1518)gGc>gAc	p.G506D		NM_003604.2	NP_003595.1	O14654	IRS4_HUMAN	insulin receptor substrate 4	506						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			NS(1)|breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(1)	78						GCCATTTGAGCCCTGGCCACC	0.592000													33	53					0	0	1	0	0
TMPRSS6	164656	broad.mit.edu	37	22	37462952	37462952	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:37462952C>T	ENST00000381792.2	-	18	2370	c.2230G>A	c.(2230-2232)Gac>Aac	p.D744N	TMPRSS6_ENST00000346753.3_Missense_Mutation_p.D731N|TMPRSS6_ENST00000406725.1_Missense_Mutation_p.D722N|TMPRSS6_ENST00000406856.1_Missense_Mutation_p.D744N			Q8IU80	TMPS6_HUMAN	transmembrane protease, serine 6	731	Peptidase S1.				angiogenesis|extracellular matrix organization|fibrinolysis|intracellular signal transduction|proteolysis	integral to membrane|intracellular|plasma membrane	serine-type endopeptidase activity			breast(5)|central_nervous_system(4)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)|stomach(3)	40						CTGCACAGGTCCTGTGGGATC	0.617000													18	10					0	0	1	0	0
DSC2	1824	broad.mit.edu	37	18	28659859	28659859	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:28659859G>A	ENST00000280904.6	-	11	2060	c.1617C>T	c.(1615-1617)acC>acT	p.T539T	DSC2_ENST00000251081.6_Silent_p.T539T	NM_024422.3	NP_077740.1	Q02487	DSC2_HUMAN	desmocollin 2	539	Cadherin 4.				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)	21			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			CATTTTTGATGGTCTCTGCCT	0.383000													39	67					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100685187	100685187	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:100685187C>T	ENST00000306151.4	+	3	10554	c.10490C>T	c.(10489-10491)tCa>tTa	p.S3497L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	3497	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					CCAACCAATTCATCTCCTACA	0.522000													177	276					0	0	1	0	0
TBC1D8	11138	broad.mit.edu	37	2	101654122	101654122	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:101654122C>A	ENST00000409318.1	-	8	1454	c.1324G>T	c.(1324-1326)Ggg>Tgg	p.G442W	TBC1D8_ENST00000376840.4_Missense_Mutation_p.G427W	NM_001102426.1	NP_001095896.1	O95759	TBCD8_HUMAN	TBC1 domain family, member 8 (with GRAM domain)	427					blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			breast(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	32						TCAAGATCCCCAAATCTGTGG	0.502000													32	60					3.03874e-20	3.08053e-20	1	1	0
GABRA6	2559	broad.mit.edu	37	5	161113986	161113986	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:161113986G>A	ENST00000523217.1	+	3	444	c.202G>A	c.(202-204)Ggg>Agg	p.G68R	GABRA6_ENST00000274545.5_Missense_Mutation_p.G68R|GABRA6_ENST00000522269.1_3'UTR	NM_000811.2	NP_000802.2	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 6	68					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(9)|liver(2)|lung(22)|ovary(7)|skin(6)|urinary_tract(2)	57	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GACCAGTTTTGGGCCCGTGTC	0.443000										TCGA Ovarian(5;0.080)			4	33					0	0	1	0	0
HIP1R	9026	broad.mit.edu	37	12	123338711	123338711	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:123338711C>T	ENST00000253083.4	+	8	824	c.699C>T	c.(697-699)ctC>ctT	p.L233L		NM_003959.1	NP_003950.1	O75146	HIP1R_HUMAN	huntingtin interacting protein 1 related	233					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			breast(1)|endometrium(5)|kidney(6)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	26	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		CGGTCAAGCTCCTGTTCAAGC	0.562000													52	54					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43219782	43219782	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:43219782C>T	ENST00000255226.6	+	7	1731	c.915C>T	c.(913-915)ttC>ttT	p.F305F	SLC14A2_ENST00000586448.1_Silent_p.F305F	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	305						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GCGGCGTGTTCCTGGTGGCTC	0.557000													42	57					0	0	1	0	0
IL1RL2	8808	broad.mit.edu	37	2	102835496	102835496	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:102835496G>A	ENST00000264257.2	+	7	934	c.808G>A	c.(808-810)Gtg>Atg	p.V270M	IL1RL2_ENST00000481806.1_3'UTR|IL1RL2_ENST00000539491.1_Missense_Mutation_p.V270M|IL1RL2_ENST00000441515.2_Missense_Mutation_p.V152M	NM_003854.2	NP_003845.2	Q9HB29	ILRL2_HUMAN	interleukin 1 receptor-like 2	270	Ig-like C2-type 3.				cellular defense response|innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|liver(2)|lung(8)|ovary(2)|prostate(1)	26						TAACACTTTGGTGGATGATTA	0.388000													33	48					0	0	1	0	0
TSNARE1	203062	broad.mit.edu	37	8	143413154	143413154	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:143413154G>A	ENST00000519651.1	-	3	230	c.127C>T	c.(127-129)Cag>Tag	p.Q43*	TSNARE1_ENST00000307180.3_Nonsense_Mutation_p.Q262*|TSNARE1_ENST00000520166.1_Nonsense_Mutation_p.Q262*|TSNARE1_ENST00000524325.1_Nonsense_Mutation_p.Q262*			Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	262					vesicle-mediated transport	integral to membrane				breast(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(6)|ovary(2)|stomach(2)|urinary_tract(1)	20	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GACATCTCCTGGAACAGCTCC	0.617000													4	10					0	0	1	0	0
TRRAP	8295	broad.mit.edu	37	7	98515105	98515105	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:98515105C>T	ENST00000359863.4	+	20	2634	c.2425C>T	c.(2425-2427)Ctg>Ttg	p.L809L	TRRAP_ENST00000446306.3_Silent_p.L808L|TRRAP_ENST00000355540.3_Silent_p.L809L	NM_001244580.1	NP_001231509.1	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated protein	809					histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			NS(3)|breast(1)|central_nervous_system(10)|endometrium(16)|kidney(7)|large_intestine(36)|liver(1)|lung(54)|ovary(10)|pancreas(1)|prostate(8)|skin(16)|stomach(5)|upper_aerodigestive_tract(6)|urinary_tract(2)	176	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CTTTGTGGAGCTGTGTCTCAC	0.567000													34	48					0	0	1	0	0
IPO11	51194	broad.mit.edu	37	5	61846259	61846259	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:61846259C>T	ENST00000325324.6	+	25	2485	c.2316C>T	c.(2314-2316)ccC>ccT	p.P772P	IPO11_ENST00000409296.3_Silent_p.P812P	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11	772						cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		CGATTTTACCCTATGTTTTCA	0.343000													21	16					0	0	1	0	0
TNN	63923	broad.mit.edu	37	1	175067711	175067711	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:175067711C>T	ENST00000239462.4	+	9	2212	c.2099C>T	c.(2098-2100)gCc>gTc	p.A700V		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	700	Fibronectin type-III 5.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGCAAGAAGGCCGACACCAAG	0.577000													16	84					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179465822	179465822	+	Silent	SNP	C	C	T	rs35647804		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179465822C>T	ENST00000589042.1	-	288	56033	c.55809G>A	c.(55807-55809)ccG>ccA	p.P18603P	TTN_ENST00000342992.6_Silent_p.P16035P|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Silent_p.P16962P|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.P9538P|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000342175.6_Silent_p.P9730P|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Silent_p.P9663P|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16962	Fibronectin type-III 34.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATCATTCTTCGGGGGTTTCC	0.458000													24	55					0	0	1	0	0
GRPR	2925	broad.mit.edu	37	X	16170694	16170694	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:16170694C>T	ENST00000380289.2	+	3	1479	c.1081C>T	c.(1081-1083)Ctc>Ttc	p.L361F		NM_005314.2	NP_005305.1	P30550	GRPR_HUMAN	gastrin-releasing peptide receptor	361					cell proliferation	integral to plasma membrane	bombesin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(12)|ovary(3)|stomach(1)|upper_aerodigestive_tract(3)	25	Hepatocellular(33;0.183)					CATGACCTCCCTCAAGAGTAC	0.527000													62	26					0	0	1	0	0
GRM5	2915	broad.mit.edu	37	11	88323880	88323880	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:88323880C>T	ENST00000418177.2	-	7	1946	c.1579G>A	c.(1579-1581)Gaa>Aaa	p.E527K	GRM5_ENST00000305447.4_Missense_Mutation_p.E527K|GRM5_ENST00000393297.1_Missense_Mutation_p.E527K|GRM5_ENST00000305432.5_Missense_Mutation_p.E527K|GRM5_ENST00000455756.2_Missense_Mutation_p.E527K			P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5	527					activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity	p.E527K(1)		NS(1)|breast(5)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(18)|lung(40)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	CAGCTGACTTCTCCCTTTCGG	0.393000													26	38					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101603398	101603398	+	Missense_Mutation	SNP	C	C	T	rs150527729		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:101603398C>T	ENST00000536262.2	-	1	787	c.229G>A	c.(229-231)Gag>Aag	p.E77K		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	77					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						CGGTAGACCTCGGAGGGGGTG	0.587000													11	43					0	0	1	0	0
WHSC1	7468	broad.mit.edu	37	4	1918700	1918700	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:1918700G>A	ENST00000503128.1	+	4	1070	c.863G>A	c.(862-864)gGa>gAa	p.G288E	WHSC1_ENST00000508803.1_Missense_Mutation_p.G288E|WHSC1_ENST00000420906.2_Missense_Mutation_p.G288E|WHSC1_ENST00000382891.5_Missense_Mutation_p.G288E|WHSC1_ENST00000382892.2_Missense_Mutation_p.G288E|WHSC1_ENST00000514045.1_Missense_Mutation_p.G288E|WHSC1_ENST00000382895.3_Missense_Mutation_p.G288E|WHSC1_ENST00000398261.1_Missense_Mutation_p.G288E			O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	288					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GAAGGAGAAGGACAGTTTGAA	0.448000			T	IGH@	MM								24	20					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176562432	176562432	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:176562432C>T	ENST00000439151.2	+	2	373	c.328C>T	c.(328-330)Cca>Tca	p.P110S	NSD1_ENST00000347982.4_Intron|NSD1_ENST00000354179.4_Intron|NSD1_ENST00000361032.4_Missense_Mutation_p.P110S|NSD1_ENST00000511258.1_Intron	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	110					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		AGCTCAGACGCCAATTGTTTG	0.438000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			19	40					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186277044	186277044	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:186277044G>A	ENST00000445192.2	+	7	2238	c.2193G>A	c.(2191-2193)aaG>aaA	p.K731K	PRG4_ENST00000367485.4_Silent_p.K638K|PRG4_ENST00000367483.4_Silent_p.K690K|PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367486.3_Silent_p.K688K	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	731	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CTGCCCCCAAGGAGCTTGCAC	0.587000													154	117					0	0	1	0	0
PLCD4	84812	broad.mit.edu	37	2	219483376	219483376	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:219483376C>T	ENST00000450993.2	+	4	595	c.256C>T	c.(256-258)Ccc>Tcc	p.P86S	PLCD4_ENST00000417849.1_Missense_Mutation_p.P86S|PLCD4_ENST00000432688.1_Missense_Mutation_p.P86S	NM_032726.3	NP_116115.1	Q9BRC7	PLCD4_HUMAN	phospholipase C, delta 4	86	PH.				intracellular signal transduction|lipid catabolic process	endoplasmic reticulum|membrane|nucleus	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(7)|ovary(3)|prostate(1)|urinary_tract(3)	23		Renal(207;0.0915)		Epithelial(149;5.11e-07)|all cancers(144;0.000104)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGAGGAGCTCCCCCTGGAGCA	0.572000													15	33					0	0	1	0	0
PRKRIR	5612	broad.mit.edu	37	11	76062171	76062171	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:76062171G>A	ENST00000260045.3	-	5	2128	c.2023C>T	c.(2023-2025)Cct>Tct	p.P675S		NM_004705.2	NP_004696.2	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)	675					negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			cervix(1)|endometrium(3)|large_intestine(4)|lung(12)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	25						TACACATTAGGAAAAAACTTG	0.428000													21	71					0	0	1	0	0
PCDH19	57526	broad.mit.edu	37	X	99662260	99662260	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:99662260C>T	ENST00000373034.4	-	1	3011	c.1336G>A	c.(1336-1338)Gaa>Aaa	p.E446K	PCDH19_ENST00000255531.7_Missense_Mutation_p.E446K|PCDH19_ENST00000420881.2_Missense_Mutation_p.E446K	NM_001184880.1	NP_001171809.1	Q8TAB3	PCD19_HUMAN	protocadherin 19	446	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(5)|endometrium(11)|kidney(1)|large_intestine(14)|liver(1)|lung(23)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	68						TTGTCATTTTCGTCAGTGATG	0.572000													30	42					0	0	1	0	0
CST1	1469	broad.mit.edu	37	20	23731383	23731383	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:23731383C>T	ENST00000304749.2	-	1	191	c.121G>A	c.(121-123)Gat>Aat	p.D41N	CST1_ENST00000398402.1_Missense_Mutation_p.D41N	NM_001898.2	NP_001889.2	P01037	CYTN_HUMAN	cystatin SN	41						extracellular region	cysteine-type endopeptidase inhibitor activity			kidney(1)|large_intestine(1)|lung(8)|ovary(1)|stomach(1)|urinary_tract(1)	13	Lung NSC(19;0.0676)|all_lung(19;0.148)					ACCCACTCATCATTGAGGTCT	0.577000													22	20					0	0	1	0	0
ADH7	131	broad.mit.edu	37	4	100349303	100349303	+	Silent	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:100349303T>A	ENST00000437033.2	-	4	791	c.288A>T	c.(286-288)ccA>ccT	p.P96P	ADH7_ENST00000209665.4_Silent_p.P108P|ADH7_ENST00000482593.1_Silent_p.P39P|ADH7_ENST00000476959.1_Silent_p.P116P			P40394	ADH7_HUMAN	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	108					ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)	19				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	CTCTACATTGTGGCAGAAAGA	0.338000													20	63					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189584501	189584501	+	Missense_Mutation	SNP	G	G	A	rs121908849		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:189584501G>A	ENST00000264731.3	+	6	886	c.797G>A	c.(796-798)cGa>cAa	p.R266Q	TP63_ENST00000392463.2_Missense_Mutation_p.R172Q|TP63_ENST00000392461.3_Missense_Mutation_p.R172Q|TP63_ENST00000456148.1_Missense_Mutation_p.R172Q|TP63_ENST00000320472.5_Missense_Mutation_p.R266Q|TP63_ENST00000440651.2_Missense_Mutation_p.R266Q|TP63_ENST00000392460.3_Missense_Mutation_p.R266Q|TP63_ENST00000437221.1_Missense_Mutation_p.R172Q|TP63_ENST00000354600.5_Missense_Mutation_p.R172Q|TP63_ENST00000418709.2_Missense_Mutation_p.R266Q|TP63_ENST00000382063.4_Missense_Mutation_p.R181Q|TP63_ENST00000449992.1_Missense_Mutation_p.R87Q	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	266			R -> Q (in EEC3).		anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CATTTGATTCGAGTAGAGGGG	0.403000										HNSCC(45;0.13)			22	31					0	0	1	0	0
OR5B12	390191	broad.mit.edu	37	11	58207369	58207369	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:58207369C>T	ENST00000302572.2	-	1	277	c.256G>A	c.(256-258)Gga>Aga	p.G86R		NM_001004733.2	NP_001004733.1	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B, member 12	86					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(6)|liver(1)|lung(28)|ovary(1)|prostate(3)|skin(1)	40	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				AATTTGTCTCCTGTGAGAAAC	0.453000													25	45					0	0	1	0	0
DEAF1	10522	broad.mit.edu	37	11	687963	687963	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:687963G>A	ENST00000382409.3	-	4	1096	c.612C>T	c.(610-612)ccC>ccT	p.P204P	DEAF1_ENST00000338675.6_Silent_p.P204P	NM_021008.2	NP_066288.2	O75398	DEAF1_HUMAN	DEAF1 transcription factor	204	SAND.				embryonic skeletal system development|germ cell development|neural tube closure|regulation of mammary gland epithelial cell proliferation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|extracellular region|nucleus	protein binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	24		all_cancers(49;1.24e-08)|all_epithelial(84;1.87e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.106)|all_lung(207;0.136)		all cancers(45;1.76e-27)|Epithelial(43;8.42e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.55e-21)|BRCA - Breast invasive adenocarcinoma(625;4.83e-05)|Lung(200;0.0259)|LUSC - Lung squamous cell carcinoma(625;0.075)		GGCACCGTACGGGCAGCTCAC	0.552000													22	24					0	0	1	0	0
SLC6A17	388662	broad.mit.edu	37	1	110717458	110717458	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:110717458C>T	ENST00000331565.4	+	5	1114	c.629C>T	c.(628-630)gCc>gTc	p.A210V		NM_001010898.2	NP_001010898.1	Q9H1V8	S6A17_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 17	210					alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			breast(1)|endometrium(4)|kidney(4)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	37		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		TACCGAGAGGCCTTGGACATC	0.582000													56	34					0	0	1	0	0
OR6T1	219874	broad.mit.edu	37	11	123814345	123814345	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:123814345G>A	ENST00000321252.2	-	1	235	c.201C>T	c.(199-201)tcC>tcT	p.S67S		NM_001005187.1	NP_001005187.1	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T, member 1	67					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GCTCCAGGAAGGAGAAATTCC	0.493000													33	52					0	0	1	0	0
SPOCK3	50859	broad.mit.edu	37	4	167656185	167656185	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:167656185C>T	ENST00000357154.3	-	12	1335	c.1198G>A	c.(1198-1200)Gat>Aat	p.D400N	SPOCK3_ENST00000535728.1_Missense_Mutation_p.D268N|SPOCK3_ENST00000510741.1_Missense_Mutation_p.D357N|SPOCK3_ENST00000506886.1_Missense_Mutation_p.D400N|SPOCK3_ENST00000511531.1_Missense_Mutation_p.D400N|SPOCK3_ENST00000541637.1_Missense_Mutation_p.D302N|SPOCK3_ENST00000534949.1_Missense_Mutation_p.D304N|SPOCK3_ENST00000504953.1_Missense_Mutation_p.D397N|SPOCK3_ENST00000541354.1_Missense_Mutation_p.D280N|SPOCK3_ENST00000507137.1_5'UTR|SPOCK3_ENST00000511269.1_Missense_Mutation_p.D397N|SPOCK3_ENST00000357545.4_Missense_Mutation_p.D397N|SPOCK3_ENST00000502330.1_Missense_Mutation_p.D400N|SPOCK3_ENST00000421836.2_Missense_Mutation_p.D349N|SPOCK3_ENST00000512681.1_Missense_Mutation_p.D302N	NM_016950.2	NP_058646.2	Q9BQ16	TICN3_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	400	Asp-rich.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		tcctcatcatcagtccattca	0.353000													9	27					0	0	1	0	0
UBE2L3	7332	broad.mit.edu	37	22	21947178	21947178	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:21947178T>C	ENST00000342192.4	+	2	254	c.56T>C	c.(55-57)aTg>aCg	p.M19T	UBE2L3_ENST00000545681.1_Intron|UBE2L3_ENST00000458578.2_Missense_Mutation_p.M77T	NM_003347.3	NP_003338.1	P68036	UB2L3_HUMAN	ubiquitin-conjugating enzyme E2L 3	19					cell proliferation|cellular response to glucocorticoid stimulus|protein K11-linked ubiquitination|regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus|ubiquitin ligase complex	ATP binding|transcription coactivator activity|ubiquitin protein ligase binding|ubiquitin-protein ligase activity		UBE2L3/KRAS(2)	large_intestine(4)	4	Colorectal(54;0.105)					AAATGTGGGATGAAAAACTTC	0.423000													25	28					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10358351	10358351	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:10358351C>T	ENST00000255381.2	-	21	2452	c.2342G>A	c.(2341-2343)cGa>cAa	p.R781Q	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	781	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CTTTTCATCTCGCATTTCCTC	0.433000													21	9					0	0	1	0	0
KIAA1551	55196	broad.mit.edu	37	12	32134683	32134683	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:32134683C>T	ENST00000312561.4	+	4	1208	c.794C>T	c.(793-795)cCa>cTa	p.P265L	KIAA1551_ENST00000535596.1_Intron	NM_018169.3	NP_060639.3			KIAA1551																		TCAGCTGTACCATCACAGCAG	0.393000													11	56					0	0	1	0	0
RGL1	23179	broad.mit.edu	37	1	183775571	183775571	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:183775571A>C	ENST00000304685.3	+	3	656	c.195A>C	c.(193-195)aaA>aaC	p.K65N	RGL1_ENST00000536277.1_Intron|RGL1_ENST00000539189.1_Missense_Mutation_p.K30N|RGL1_ENST00000360851.3_Missense_Mutation_p.K30N|RGL1_ENST00000367531.1_Missense_Mutation_p.K65N	NM_015149.3	NP_055964.3	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation stimulator-like 1	30	N-terminal Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(17)|ovary(4)|prostate(3)|stomach(1)	51						TCACCCTCAAAAGAGTCCAGA	0.478000													21	90					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90402324	90402324	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:90402324G>A	ENST00000369393.3	-	63	10540	c.10425C>T	c.(10423-10425)atC>atT	p.I3475I	MDN1_ENST00000428876.1_Silent_p.I3475I			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	3475					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGCGCTTGAGGATTAGCTTCC	0.577000													34	111					0	0	1	0	0
FLG	2312	broad.mit.edu	37	1	152284234	152284234	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:152284234C>T	ENST00000368799.1	-	3	3163	c.3128G>A	c.(3127-3129)aGc>aAc	p.S1043N	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	1043	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTGTCTGGAGCTGTCTGCTGA	0.572000									Ichthyosis				135	713					0	0	1	0	0
CRYGA	1418	broad.mit.edu	37	2	209027999	209027999	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:209027999C>T	ENST00000304502.4	-	2	200	c.181G>A	c.(181-183)Ggc>Agc	p.G61S		NM_014617.3	NP_055432.2			crystallin, gamma A											endometrium(1)|kidney(3)|large_intestine(1)|lung(7)	12				Epithelial(149;0.067)|LUSC - Lung squamous cell carcinoma(261;0.0708)|Lung(261;0.135)		GGGTACTTGCCTCGGCGCAGG	0.557000													31	46					0	0	1	0	0
ATP6AP2	10159	broad.mit.edu	37	X	40456805	40456805	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:40456805C>T	ENST00000378438.4	+	5	581	c.423C>T	c.(421-423)aaC>aaT	p.N141N	ATP6AP2_ENST00000535777.1_Intron|ATP6AP2_ENST00000544975.1_Silent_p.N65N|ATP6AP2_ENST00000535539.1_Silent_p.N109N|ATP6AP2_ENST00000486558.1_3'UTR	NM_005765.2	NP_005756.2	O75787	RENR_HUMAN	ATPase, H+ transporting, lysosomal accessory protein 2	141					angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity			endometrium(1)|large_intestine(1)|lung(2)	4						GGAAGGCAAACTCAGTGTTTG	0.413000													39	17					0	0	1	0	0
FCHSD2	9873	broad.mit.edu	37	11	72549866	72549866	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:72549866C>T	ENST00000409314.1	-	21	2433	c.2265G>A	c.(2263-2265)aaG>aaA	p.K755K	FCHSD2_ENST00000311172.7_Silent_p.K675K|FCHSD2_ENST00000458644.2_Silent_p.K595K|FCHSD2_ENST00000409263.1_Silent_p.K92K|FCHSD2_ENST00000409418.4_Silent_p.K731K|ATG16L2_ENST00000534905.1_Intron			O94868	FCSD2_HUMAN	FCH and double SH3 domains 2	731							protein binding			endometrium(2)|large_intestine(11)|lung(5)|ovary(2)|prostate(1)|skin(1)	22			BRCA - Breast invasive adenocarcinoma(5;3.3e-05)			CATCTTCAATCTTCTCTGCTG	0.498000													3	10					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168123334	168123334	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:168123334G>A	ENST00000519560.1	-	28	3464	c.3045C>T	c.(3043-3045)atC>atT	p.I1015I	SLIT3_ENST00000332966.8_Silent_p.I1022I|SLIT3_ENST00000404867.3_Silent_p.I1015I	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	1015	EGF-like 3.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CGTAGTTGTTGATCCCGTCCA	0.527000													58	46					0	0	1	0	0
ZNF786	136051	broad.mit.edu	37	7	148768833	148768833	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:148768833G>A	ENST00000316286.9	-	3	1045	c.773C>T	c.(772-774)tCg>tTg	p.S258L	ZNF786_ENST00000491431.1_Missense_Mutation_p.S344L|ZNF786_ENST00000451334.3_Missense_Mutation_p.S307L			Q8N393	ZN786_HUMAN	zinc finger protein 786	344					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(4)|cervix(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(2)|skin(2)|soft_tissue(1)|urinary_tract(2)	26	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			GGGCAGGCGCGAGCCTGGTTT	0.721000													11	14					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454755	84454755	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:84454755C>T	ENST00000377084.2	-	1	1773	c.888G>A	c.(886-888)gaG>gaA	p.E296E		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	296						integral to membrane		p.E296D(1)		NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		TGGCATGATCCTCTTGCCCAT	0.552000													15	34					0	0	1	0	0
BRD8	10902	broad.mit.edu	37	5	137481495	137481495	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:137481495C>T	ENST00000254900.5	-	24	3722	c.3351G>A	c.(3349-3351)aaG>aaA	p.K1117K		NM_139199.1	NP_631938.1	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	1117					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TGGCAATCATCTTCCAGACTG	0.408000													7	21					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537893	55537893	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:55537893C>T	ENST00000220676.1	+	4	1599	c.1451C>T	c.(1450-1452)tCa>tTa	p.S484L		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	484					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GGACAGTTTTCATATAGTGAA	0.373000													24	26					0	0	1	0	0
PADI1	29943	broad.mit.edu	37	1	17555245	17555245	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:17555245G>A	ENST00000375471.4	+	7	870	c.778G>A	c.(778-780)Gat>Aat	p.D260N		NM_013358.2	NP_037490.2	Q9ULC6	PADI1_HUMAN	peptidyl arginine deiminase, type I	260					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	28		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.00054)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00522)|BRCA - Breast invasive adenocarcinoma(304;1.3e-05)|COAD - Colon adenocarcinoma(227;1.31e-05)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(196;0.0069)|READ - Rectum adenocarcinoma(331;0.0681)|Lung(427;0.197)	L-Citrulline(DB00155)	CCCCGATGCCGATTTCCTAGG	0.627000													130	67					0	0	1	0	0
FAM172A	83989	broad.mit.edu	37	5	93159893	93159893	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:93159893G>A	ENST00000395965.3	-	8	1009	c.867C>T	c.(865-867)ttC>ttT	p.F289F	FAM172A_ENST00000505869.1_Silent_p.F179F|FAM172A_ENST00000509739.1_Silent_p.F142F|FAM172A_ENST00000509163.1_Silent_p.F243F	NM_032042.5	NP_114431.2	Q8WUF8	F172A_HUMAN	family with sequence similarity 172, member A	289						endoplasmic reticulum|extracellular region				endometrium(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	9						TGTGAGCAACGAAAAACACAT	0.413000													26	59					0	0	1	0	0
LIPJ	142910	broad.mit.edu	37	10	90356597	90356597	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:90356597C>T	ENST00000371939.3	+	8	941	c.627C>T	c.(625-627)ttC>ttT	p.F209F		NM_001010939.2	NP_001010939.2	Q5W064	LIPJ_HUMAN	lipase, family member J	209					lipid catabolic process		hydrolase activity			large_intestine(4)|lung(4)|ovary(1)	9		all_cancers(4;2.79e-10)|Prostate(4;1.68e-15)|all_epithelial(4;1.43e-09)|Colorectal(252;0.0381)|Breast(4;0.141)|Melanoma(5;0.2)|all_hematologic(4;0.222)		Colorectal(12;1.02e-05)|COAD - Colon adenocarcinoma(12;1.54e-05)		TTAAAAAATTCATTGGTTCAA	0.308000													28	14					0	0	1	0	0
LMOD1	25802	broad.mit.edu	37	1	201869690	201869690	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:201869690C>T	ENST00000367288.4	-	2	697	c.451G>A	c.(451-453)Gag>Aag	p.E151K		NM_012134.2	NP_036266.2	P29536	LMOD1_HUMAN	leiomodin 1 (smooth muscle)	151					muscle contraction	cytoskeleton|cytosol|membrane fraction	tropomyosin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						ATCTTCTCCTCCTTGGGCTTC	0.567000													23	108					0	0	1	0	0
OR4S2	219431	broad.mit.edu	37	11	55419098	55419098	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:55419098C>T	ENST00000312422.2	+	1	719	c.719C>T	c.(718-720)tCc>tTc	p.S240F		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	240					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				ACCTGTGGCTCCCACATTGCC	0.483000													40	10					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100211856	100211856	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:100211856G>A	ENST00000524871.1	+	23	3239	c.2949G>A	c.(2947-2949)tgG>tgA	p.W983*	CNTN5_ENST00000418526.2_Nonsense_Mutation_p.W909*|CNTN5_ENST00000528682.1_Nonsense_Mutation_p.W983*|CNTN5_ENST00000279463.3_Nonsense_Mutation_p.W983*|CNTN5_ENST00000524560.1_3'UTR	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	983	Fibronectin type-III 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		ACCTCAGGTGGGAGCAGCAAG	0.428000													38	73					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52034141	52034141	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:52034141G>A	ENST00000346477.3	-	3	568	c.500C>T	c.(499-501)tCt>tTt	p.S167F	SIGLEC6_ENST00000425629.3_Missense_Mutation_p.S167F|SIGLEC6_ENST00000436458.1_Missense_Mutation_p.S131F|SIGLEC6_ENST00000391797.3_Missense_Mutation_p.S156F|SIGLEC6_ENST00000359982.4_Missense_Mutation_p.S167F|SIGLEC6_ENST00000343300.4_Missense_Mutation_p.S167F	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	167	Ig-like C2-type 1.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		CCAGGGCACAGAGCAGGTCAG	0.657000													51	34					0	0	1	0	0
SERPINA10	51156	broad.mit.edu	37	14	94754772	94754772	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:94754772C>T	ENST00000554723.1	-	3	1381	c.963G>A	c.(961-963)aaG>aaA	p.K321K	SERPINA10_ENST00000554173.1_Silent_p.K281K|SERPINA10_ENST00000393096.1_Silent_p.K281K|SERPINA10_ENST00000261994.4_Silent_p.K281K			Q9UK55	ZPI_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10	281					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)	33		all_cancers(154;0.105)		Epithelial(152;0.135)|COAD - Colon adenocarcinoma(157;0.207)|all cancers(159;0.221)		AACGAAAATTCTTGTCAAAGG	0.502000													20	12					0	0	1	0	0
ANKRD13D	338692	broad.mit.edu	37	11	67069777	67069777	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:67069777C>T	ENST00000447274.2	+	15	2706	c.1531C>T	c.(1531-1533)Ctg>Ttg	p.L511L	ANKRD13D_ENST00000515828.1_Silent_p.L248L|ANKRD13D_ENST00000514166.1_Silent_p.L511L|ANKRD13D_ENST00000504236.1_3'UTR|ANKRD13D_ENST00000511455.2_Silent_p.L598L|ANKRD13D_ENST00000308440.6_Silent_p.L511L			Q6ZTN6	AN13D_HUMAN	ankyrin repeat domain 13 family, member D	511										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			ACAGCGGATCCTGCAGCTGTC	0.597000													3	3					0	0	1	0	0
HDAC9	9734	broad.mit.edu	37	7	18633644	18633644	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:18633644G>A	ENST00000406451.3	+	6	797	c.647G>A	c.(646-648)cGa>cAa	p.R216Q	HDAC9_ENST00000417496.2_Missense_Mutation_p.R258Q|HDAC9_ENST00000401921.1_Missense_Mutation_p.R219Q|HDAC9_ENST00000524023.1_Missense_Mutation_p.R183Q|HDAC9_ENST00000441542.2_Missense_Mutation_p.R219Q|HDAC9_ENST00000428307.2_Missense_Mutation_p.R216Q|HDAC9_ENST00000405010.3_Missense_Mutation_p.R216Q|HDAC9_ENST00000432645.2_Missense_Mutation_p.R216Q|HDAC9_ENST00000406072.1_Missense_Mutation_p.R247Q|HDAC9_ENST00000456174.2_Missense_Mutation_p.R188Q	NM_178423.1|NM_178425.2	NP_848510.1|NP_848512.1	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9	216	Interaction with MAPK10 (By similarity).				B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			breast(3)|central_nervous_system(4)|cervix(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|liver(2)|lung(37)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	82	all_lung(11;0.187)				Valproic Acid(DB00313)	TTCCCCCTTCGAAAAACTGGT	0.418000													17	32					0	0	1	0	0
TMEM176B	28959	broad.mit.edu	37	7	150490253	150490253	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:150490253C>T	ENST00000447204.2	-	5	895	c.523G>A	c.(523-525)Ggg>Agg	p.G175R	TMEM176B_ENST00000429904.2_Missense_Mutation_p.G175R|TMEM176B_ENST00000450753.2_Missense_Mutation_p.G138R|TMEM176B_ENST00000326442.5_Missense_Mutation_p.G175R|TMEM176B_ENST00000434545.1_Missense_Mutation_p.G175R|TMEM176B_ENST00000492607.1_Missense_Mutation_p.G175R	NM_014020.3	NP_054739.3	Q3YBM2	T176B_HUMAN	transmembrane protein 176B	175					cell differentiation|organ morphogenesis	integral to membrane|nuclear membrane				cervix(1)|large_intestine(4)|lung(10)|ovary(1)|skin(3)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CATCTGTACCCAGTGGTAGGG	0.502000													29	56					0	0	1	0	0
INO80E	283899	broad.mit.edu	37	16	30012803	30012803	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:30012803C>T	ENST00000563197.1	+	6	1482	c.465C>T	c.(463-465)ccC>ccT	p.P155P	INO80E_ENST00000304516.7_Intron|INO80E_ENST00000567705.1_Silent_p.P138P|INO80E_ENST00000567254.1_Silent_p.P155P	NM_173618.1	NP_775889.1	Q8NBZ0	IN80E_HUMAN	INO80 complex subunit E	155	Pro-rich.				DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ino80 complex				endometrium(1)|large_intestine(2)|lung(1)|skin(1)|urinary_tract(1)	6						AGCCCAGTCCCCTGAGGCCCA	0.697000													8	8					0	0	1	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186925455	186925455	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:186925455G>A	ENST00000367466.3	+	14	1710	c.1558G>A	c.(1558-1560)Gaa>Aaa	p.E520K	PLA2G4A_ENST00000442353.2_Missense_Mutation_p.E460K	NM_024420.2	NP_077734.1	P47712	PA24A_HUMAN	phospholipase A2, group IVA (cytosolic, calcium-dependent)	520	PLA2c.				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|prostate(3)|skin(4)|stomach(1)	53					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	TGATGATGATGAACTGGATGC	0.408000													107	53					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38831833	38831833	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:38831833G>A	ENST00000359357.3	+	43	6098	c.5844G>A	c.(5842-5844)acG>acA	p.T1948T	DNAH8_ENST00000449981.2_Silent_p.T2165T|DNAH8_ENST00000441566.1_Silent_p.T1948T					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TCTTCTTAACGATGGTGAGAA	0.289000													20	12					0	0	1	0	0
PIK3AP1	118788	broad.mit.edu	37	10	98363751	98363751	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:98363751C>T	ENST00000339364.5	-	15	2345	c.2226G>A	c.(2224-2226)atG>atA	p.M742I	PIK3AP1_ENST00000371109.3_Missense_Mutation_p.M341I|PIK3AP1_ENST00000371110.2_Missense_Mutation_p.M564I	NM_152309.2	NP_689522.2	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	742						cytoplasm|plasma membrane				NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(27)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)	52		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		TGTCCCCTTCCATCCCGCTGC	0.552000													7	0					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197390421	197390421	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:197390421T>A	ENST00000367400.3	+	6	1598	c.1463T>A	c.(1462-1464)tTt>tAt	p.F488Y	CRB1_ENST00000543483.1_Missense_Mutation_p.F187Y|CRB1_ENST00000535699.1_Missense_Mutation_p.F419Y|CRB1_ENST00000538660.1_Missense_Mutation_p.F488Y|CRB1_ENST00000476483.1_3'UTR|CRB1_ENST00000367397.1_5'UTR|CRB1_ENST00000544212.1_5'UTR|CRB1_ENST00000367399.2_Missense_Mutation_p.F376Y	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	488	Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						ACACTTTCATTTGAGGGCGAT	0.517000													49	23					0	0	1	0	0
OPRK1	4986	broad.mit.edu	37	8	54147591	54147591	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:54147591G>A	ENST00000265572.3	-	3	635	c.338C>T	c.(337-339)cCc>cTc	p.P113L	RP11-162D9.3_ENST00000524425.1_RNA|OPRK1_ENST00000524278.1_Missense_Mutation_p.P24L|OPRK1_ENST00000520287.1_Missense_Mutation_p.P113L	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	113					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	ACTCTGAAAGGGCATGGTTGT	0.383000													32	66					0	0	1	0	0
PPFIA2	8499	broad.mit.edu	37	12	81719558	81719558	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:81719558T>A	ENST00000550584.2	-	21	2935	c.2640A>T	c.(2638-2640)aaA>aaT	p.K880N	PPFIA2_ENST00000443686.3_Missense_Mutation_p.K781N|PPFIA2_ENST00000548586.1_Missense_Mutation_p.K880N|PPFIA2_ENST00000333447.7_Missense_Mutation_p.K862N|PPFIA2_ENST00000407050.4_Missense_Mutation_p.K806N|PPFIA2_ENST00000549325.1_Missense_Mutation_p.K862N|PPFIA2_ENST00000545296.2_Intron|PPFIA2_ENST00000550359.2_Missense_Mutation_p.K727N|PPFIA2_ENST00000552948.1_Missense_Mutation_p.K880N|PPFIA2_ENST00000541017.1_Missense_Mutation_p.K97N|PPFIA2_ENST00000541570.2_Missense_Mutation_p.K447N|PPFIA2_ENST00000549396.1_Missense_Mutation_p.K880N	NM_001220473.1	NP_001207402.1	B7Z663	B7Z663_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2	806										NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(15)|lung(37)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)	85						AAACCTACTTTTTCTTTAGTC	0.393000													8	17					0	0	1	0	0
EDC3	80153	broad.mit.edu	37	15	74964078	74964078	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:74964078G>A	ENST00000315127.4	-	3	383	c.202C>T	c.(202-204)Cca>Tca	p.P68S	EDC3_ENST00000568176.1_Missense_Mutation_p.P68S|EDC3_ENST00000426797.3_Missense_Mutation_p.P68S	NM_001142444.1|NM_025083.3	NP_001135916.1|NP_079359.2	Q96F86	EDC3_HUMAN	enhancer of mRNA decapping 3	68	Required for P-body targeting and interaction with DCP1A (By similarity).				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	cytoplasmic mRNA processing body|cytosol	protein binding|RNA binding			breast(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16						CCAGGTCCTGGTATCTCCAGA	0.433000													44	37					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228558433	228558433	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:228558433C>T	ENST00000570156.2	+	104	23165	c.23091C>T	c.(23089-23091)ttC>ttT	p.F7697F	OBSCN_ENST00000366707.4_Silent_p.F4374F|OBSCN_ENST00000422127.1_Silent_p.F6740F	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	6740	Protein kinase 2.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				AGCTCAAGTTCCTCCTGGCCC	0.632000													23	117					0	0	1	0	0
SNTG2	54221	broad.mit.edu	37	2	1079275	1079275	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:1079275G>A	ENST00000308624.5	+	2	273	c.144G>A	c.(142-144)acG>acA	p.T48T	SNTG2_ENST00000407292.1_Silent_p.T48T	NM_018968.3	NP_061841.2	Q9NY99	SNTG2_HUMAN	syntrophin, gamma 2	48					central nervous system development	cytoplasm|cytoskeleton|sarcolemma|syntrophin complex	actin binding|PDZ domain binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.00469)		all cancers(51;0.0178)|OV - Ovarian serous cystadenocarcinoma(76;0.07)|Epithelial(75;0.0864)|GBM - Glioblastoma multiforme(21;0.173)		TGAAGCTGACGAAAGAGGTGC	0.468000													19	55					0	0	1	0	0
RXFP2	122042	broad.mit.edu	37	13	32355862	32355862	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:32355862C>T	ENST00000298386.2	+	10	911	c.840C>T	c.(838-840)tgC>tgT	p.C280C	RXFP2_ENST00000380314.1_Silent_p.C280C	NM_130806.3	NP_570718.1	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	280						integral to membrane|plasma membrane				cervix(1)|endometrium(2)|large_intestine(15)|lung(13)|prostate(1)|stomach(1)	33		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		TTCTGTCGTGCGATTCGCTCA	0.323000													4	58					0	0	1	0	0
CPA5	93979	broad.mit.edu	37	7	129989871	129989871	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:129989871C>T	ENST00000485477.1	+	4	1383	c.254C>T	c.(253-255)cCt>cTt	p.P85L	CPA5_ENST00000474905.1_Missense_Mutation_p.P85L|CPA5_ENST00000466363.2_Missense_Mutation_p.P85L|CPA5_ENST00000431780.2_Missense_Mutation_p.P85L|CPA5_ENST00000355388.3_Missense_Mutation_p.P85L|CPA5_ENST00000393213.3_Missense_Mutation_p.P85L|CPA5_ENST00000461828.1_Missense_Mutation_p.P85L			Q8WXQ8	CBPA5_HUMAN	carboxypeptidase A5	85					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(2)|breast(2)|endometrium(2)|large_intestine(7)|lung(4)|ovary(3)|pancreas(1)|skin(2)	23	Melanoma(18;0.0435)					ATGAGAGTTCCTTTCTCTGAA	0.517000													65	77					0	0	1	0	0
LARP6	55323	broad.mit.edu	37	15	71124999	71124999	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:71124999G>A	ENST00000299213.8	-	3	938	c.868C>T	c.(868-870)Ctg>Ttg	p.L290L		NM_018357.2	NP_060827.2	Q9BRS8	LARP6_HUMAN	La ribonucleoprotein domain family, member 6	290					RNA processing	Golgi apparatus|nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|upper_aerodigestive_tract(1)	19						ATACCAATCAGGACAGCTTTC	0.502000													16	47					0	0	1	0	0
UBE3D	90025	broad.mit.edu	37	6	83728787	83728787	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:83728787G>A	ENST00000369747.3	-	8	1037	c.915C>T	c.(913-915)ttC>ttT	p.F305F		NM_198920.1	NP_944602.1	Q7Z6J8	UB2CB_HUMAN	ubiquitin protein ligase E3D	305						cytoplasm	ligase activity										CCAACAAGGGGAATTTTTTGA	0.378000													40	36					0	0	1	0	0
MOCS1	4337	broad.mit.edu	37	6	39874869	39874869	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:39874869G>A	ENST00000308559.7	-	10	1260	c.1127C>T	c.(1126-1128)tCc>tTc	p.S376F	MOCS1_ENST00000425303.2_Missense_Mutation_p.S392F|MOCS1_ENST00000340692.5_Missense_Mutation_p.S392F|MOCS1_ENST00000373188.2_3'UTR|MOCS1_ENST00000373175.4_3'UTR|MOCS1_ENST00000373195.3_Missense_Mutation_p.S289F|MOCS1_ENST00000373186.4_3'UTR			Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis 1	392	Molybdenum cofactor biosynthesis protein A.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|liver(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	21	Ovarian(28;0.0355)|Colorectal(47;0.196)					GGCTGGTGGGGAATTGGGGAA	0.473000													30	22					0	0	1	0	0
KRTAP6-1	337966	broad.mit.edu	37	21	31986039	31986039	+	Missense_Mutation	SNP	C	C	T	rs144374144		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:31986039C>T	ENST00000329122.2	-	1	210	c.185G>A	c.(184-186)gGa>gAa	p.G62E		NM_181602.1	NP_853633.1	Q3LI64	KRA61_HUMAN	keratin associated protein 6-1	62						cytosol|intermediate filament		p.G62V(1)		breast(2)|endometrium(1)|lung(7)	10						AGAGCCGCATCCATAGCCATA	0.562000													80	127					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70889137	70889137	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:70889137C>T	ENST00000393567.2	-	73	12487	c.12337G>A	c.(12337-12339)Gag>Aag	p.E4113K		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	4113										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				AACCCCTGCTCCTCCTTGTTA	0.547000													30	67					0	0	1	0	0
ARHGAP30	257106	broad.mit.edu	37	1	161018781	161018781	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:161018781C>T	ENST00000368013.3	-	12	2350	c.2030G>A	c.(2029-2031)gGa>gAa	p.G677E	ARHGAP30_ENST00000368016.3_Missense_Mutation_p.G677E|ARHGAP30_ENST00000368015.1_Missense_Mutation_p.G500E	NM_001025598.1|NM_181720.2	NP_001020769.1|NP_859071.2	Q7Z6I6	RHG30_HUMAN	Rho GTPase activating protein 30	677	Glu-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			breast(2)|cervix(3)|endometrium(4)|kidney(2)|large_intestine(4)|lung(6)|ovary(4)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	all_cancers(52;8.05e-20)|Breast(13;0.00188)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00122)			CTCTGGACTTCCCTCTGCCTC	0.592000													158	66					0	0	1	0	0
ZNF217	7764	broad.mit.edu	37	20	52192400	52192400	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:52192400G>A	ENST00000371471.2	-	4	3328	c.2903C>T	c.(2902-2904)cCc>cTc	p.P968L	ZNF217_ENST00000302342.3_Missense_Mutation_p.P968L			O75362	ZN217_HUMAN	zinc finger protein 217	968					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(17)|ovary(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			CCTTGGTTTGGGAGGCAGCGC	0.532000													33	46					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158655074	158655074	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:158655074C>T	ENST00000368148.3	-	2	268	c.88G>A	c.(88-90)Gaa>Aaa	p.E30K	SPTA1_ENST00000368147.3_Missense_Mutation_p.E30K	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	30					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					GTCAACACTTCCTGACGCCTC	0.473000													82	45					0	0	1	0	0
KPNA5	3841	broad.mit.edu	37	6	117053478	117053478	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:117053478C>T	ENST00000368564.1	+	14	1760	c.1612C>T	c.(1612-1614)Caa>Taa	p.Q538*	KPNA5_ENST00000356348.1_Nonsense_Mutation_p.Q538*			O15131	IMA5_HUMAN	karyopherin alpha 5 (importin alpha 6)	535					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding|protein transporter activity			breast(6)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0298)|all cancers(137;0.0461)|OV - Ovarian serous cystadenocarcinoma(136;0.0513)|Epithelial(106;0.212)		GGATGGATTTCAACTTTAACT	0.373000													17	49					0	0	1	0	0
BHLHB9	80823	broad.mit.edu	37	X	102005056	102005056	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:102005056C>T	ENST00000372735.1	+	4	1718	c.1133C>T	c.(1132-1134)tCc>tTc	p.S378F	BHLHB9_ENST00000361229.4_Missense_Mutation_p.S378F|BHLHB9_ENST00000448867.1_Missense_Mutation_p.S378F|BHLHB9_ENST00000457056.1_Missense_Mutation_p.S378F|BHLHB9_ENST00000447531.1_Missense_Mutation_p.S378F			Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class B, 9	378						cytoplasm|nucleus	binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						AGTTTTCCTTCCCCTGAAATG	0.383000													22	1					0	0	1	0	0
FRMD7	90167	broad.mit.edu	37	X	131218612	131218612	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:131218612C>T	ENST00000298542.4	-	8	822	c.645_splice	c.e8-1	p.G216_splice	FRMD7_ENST00000370879.1_Splice_Site_p.G96_splice|FRMD7_ENST00000464296.1_Splice_Site_p.G201_splice	NM_194277.2	NP_919253.1	Q6ZUT3	FRMD7_HUMAN	FERM domain containing 7	216	FERM.				regulation of neuron projection development	cytoskeleton|growth cone|neuronal cell body	binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(12)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	24	Acute lymphoblastic leukemia(192;0.000127)					CTTTGTATTTCCCTACAATGA	0.358000													21	4					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94067104	94067104	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:94067104C>T	ENST00000553484.1	+	25	3716	c.3562C>T	c.(3562-3564)Cct>Tct	p.P1188S	UNC79_ENST00000256339.4_Missense_Mutation_p.P1011S|UNC79_ENST00000393151.2_Missense_Mutation_p.P1188S|UNC79_ENST00000555664.1_Missense_Mutation_p.P1188S			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1188						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						CAAGGAATTTCCTTTTCCTAC	0.403000													21	7					0	0	1	0	0
IL1F10	84639	broad.mit.edu	37	2	113832414	113832414	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:113832414C>T	ENST00000393197.2	+	3	654	c.233C>T	c.(232-234)tCc>tTc	p.S78F	IL1F10_ENST00000341010.2_Missense_Mutation_p.S78F|IL1F10_ENST00000337569.3_Missense_Mutation_p.S78F	NM_032556.5	NP_115945.4	Q8WWZ1	IL1FA_HUMAN	interleukin 1 family, member 10 (theta)	78						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			endometrium(1)|lung(6)|ovary(1)	8						GAGGGGCCTTCCCTACAGCTG	0.607000													19	20					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58285269	58285269	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:58285269C>T	ENST00000249750.4	-	6	1325	c.558G>A	c.(556-558)tgG>tgA	p.W186*	ALDH1A2_ENST00000347587.3_Nonsense_Mutation_p.W186*|ALDH1A2_ENST00000559517.1_Nonsense_Mutation_p.W90*|ALDH1A2_ENST00000558231.1_Nonsense_Mutation_p.W157*|ALDH1A2_ENST00000537372.1_Nonsense_Mutation_p.W165*	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	186					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	GGGGGAAGTTCCACTGAAAGG	0.418000													11	26					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20611712	20611712	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:20611712G>A	ENST00000504154.1	+	34	4021	c.3769G>A	c.(3769-3771)Gat>Aat	p.D1257N	SLIT2_ENST00000273739.5_Missense_Mutation_p.D1270N|SLIT2_ENST00000503823.1_Missense_Mutation_p.D1249N|SLIT2_ENST00000503837.1_Missense_Mutation_p.D1253N	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	1257	Laminin G-like.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						TTTGTCCGTGGATGGTGGGAA	0.433000													41	25					0	0	1	0	0
MST1L	11223	broad.mit.edu	37	1	17083837	17083837	+	RNA	SNP	T	T	C	rs7798	by1000genomes	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:17083837T>C	ENST00000455405.2	-	0	751																											CTAATTCCTTTCAGGACCCAG	0.572000													6	31					0	0	1	0	0
NFATC2	4773	broad.mit.edu	37	20	50049033	50049033	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:50049033A>G	ENST00000371564.3	-	9	2512	c.2293T>C	c.(2293-2295)Tat>Cat	p.Y765H	NFATC2_ENST00000414705.1_Missense_Mutation_p.Y745H|NFATC2_ENST00000396009.3_Missense_Mutation_p.Y765H	NM_001258296.1|NM_012340.4	NP_001245225.1|NP_036472.2	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	765					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity		EWSR1/NFATC2(9)	breast(2)|endometrium(7)|kidney(1)|large_intestine(7)|lung(25)|ovary(2)|prostate(2)|skin(5)|stomach(1)|urinary_tract(1)	53	Hepatocellular(150;0.248)					GGCTGCTGATAGCCCAGCAGG	0.701000													17	37					0	0	1	0	0
ANKRD12	23253	broad.mit.edu	37	18	9258556	9258556	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:9258556C>T	ENST00000383440.2	+	8	5479	c.5222C>T	c.(5221-5223)tCc>tTc	p.S1741F	ANKRD12_ENST00000400020.3_Missense_Mutation_p.S1741F|ANKRD12_ENST00000262126.3_Missense_Mutation_p.S1764F	NM_001083625.2	NP_001077094.1	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12	1764						nucleus				NS(1)|breast(3)|central_nervous_system(2)|endometrium(8)|kidney(2)|large_intestine(20)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(2)	65						GACAGTGAATCCTCATCTCCT	0.393000													18	23					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10944679	10944679	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:10944679C>T	ENST00000298232.7	-	10	868	c.501G>A	c.(499-501)agG>agA	p.R167R	TPTE_ENST00000361285.4_Silent_p.R185R|TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000342420.5_Silent_p.R147R	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	185					signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TGGGAATATTCCTAAGCAACT	0.284000													21	164					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128634704	128634704	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:128634704G>A	ENST00000281428.8	+	1	20	c.20G>A	c.(19-21)gGc>gAc	p.G7D	FLI1_ENST00000429175.2_Intron|FLI1_ENST00000534087.1_Intron|FLI1_ENST00000344954.6_Intron|FLI1_ENST00000527767.2_Intron|FLI1_ENST00000525560.1_Intron	NM_001271010.1	NP_001257939.1	Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	0					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		GGACTGGCAGGCGAGCGGGCG	0.662000			T	EWSR1	Ewing sarcoma								3	10					0	0	1	0	0
KRT6B	3854	broad.mit.edu	37	12	52842734	52842734	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:52842734G>A	ENST00000252252.3	-	6	1142	c.1095C>T	c.(1093-1095)atC>atT	p.I365I		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	365	Coil 2.|Rod.		I -> V (in dbSNP:rs437014).		ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		TGCCTGCTGTGATCTGCAGCT	0.537000													38	37					0	0	1	0	0
STK10	6793	broad.mit.edu	37	5	171520516	171520516	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:171520516G>A	ENST00000176763.5	-	9	1797	c.1454C>T	c.(1453-1455)tCg>tTg	p.S485L	STK10_ENST00000517775.1_5'UTR	NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	485							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCTGCAGTCCGAGTCCCTCTT	0.607000													55	100					0	0	1	0	0
LOC100128164	100128164	broad.mit.edu	37	3	169664211	169664211	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:169664211C>T	ENST00000483289.2	-	0	3083				RP11-379K17.4_ENST00000487580.1_RNA	NR_027622.1																						GATCTCCTGCCACAAAGGCCT	0.512000													26	40					0	0	1	0	0
TRAK1	22906	broad.mit.edu	37	3	42229622	42229622	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:42229622C>T	ENST00000327628.5	+	5	966	c.566C>T	c.(565-567)tCc>tTc	p.S189F	TRAK1_ENST00000449246.1_Missense_Mutation_p.S115F|TRAK1_ENST00000487159.1_3'UTR|TRAK1_ENST00000341421.3_Missense_Mutation_p.S131F|TRAK1_ENST00000396175.1_Missense_Mutation_p.S131F	NM_001042646.2	NP_001036111.1	Q9UPV9	TRAK1_HUMAN	trafficking protein, kinesin binding 1	189	HAP1 N-terminal.				endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	22						GAGCCCGAGTCCGTTTGCTCA	0.582000													60	63					0	0	1	0	0
SLC38A4	55089	broad.mit.edu	37	12	47186797	47186797	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:47186797C>T	ENST00000447411.1	-	2	264	c.58G>A	c.(58-60)Gga>Aga	p.G20R	SLC38A4_ENST00000266579.4_Missense_Mutation_p.G20R	NM_001143824.1	NP_001137296.1	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4	20					cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	21	Lung SC(27;0.192)|Renal(347;0.236)					GCACTTTCTCCACTGCTGCTC	0.443000													49	52					0	0	1	0	0
GRM8	2918	broad.mit.edu	37	7	126173355	126173355	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:126173355G>T	ENST00000339582.2	-	9	2889	c.2081C>A	c.(2080-2082)tCt>tAt	p.S694Y	GRM8_ENST00000480995.1_5'UTR|GRM8_ENST00000358373.3_Missense_Mutation_p.S694Y|GRM8_ENST00000444921.2_Missense_Mutation_p.S694Y			O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8	694					negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(16)|lung(62)|ovary(5)|pancreas(1)|prostate(1)|skin(14)|stomach(1)|upper_aerodigestive_tract(6)|urinary_tract(4)	125		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CACCAGCTGAGATGCTGGACT	0.498000										HNSCC(24;0.065)			37	26					2.19489e-29	2.22804e-29	1	1	0
TMEM131	23505	broad.mit.edu	37	2	98378574	98378574	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:98378574G>A	ENST00000186436.5	-	36	5041	c.4813C>T	c.(4813-4815)Ccg>Tcg	p.P1605S		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	1605						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						GGGGGAGACGGGGAAGCAGGT	0.547000													23	38					0	0	1	0	0
BCLAF1	9774	broad.mit.edu	37	6	136599037	136599037	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:136599037G>A	ENST00000531224.1	-	4	1234	c.982C>T	c.(982-984)Cag>Tag	p.Q328*	BCLAF1_ENST00000527536.1_Nonsense_Mutation_p.Q328*|BCLAF1_ENST00000353331.4_Nonsense_Mutation_p.Q326*|BCLAF1_ENST00000392348.2_Nonsense_Mutation_p.Q326*|BCLAF1_ENST00000527759.1_Nonsense_Mutation_p.Q326*|BCLAF1_ENST00000530767.1_Nonsense_Mutation_p.Q328*	NM_001077441.1|NM_014739.2	NP_001070909.1|NP_055554.1	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1	328					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|ovary(1)|skin(1)	9	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GCAGTTTCCTGATCTCCACCA	0.388000													21	71					0	0	1	0	0
LPPR2	64748	broad.mit.edu	37	19	11470529	11470529	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:11470529C>T	ENST00000251473.5	+	5	664	c.288C>T	c.(286-288)ttC>ttT	p.F96F	DKFZP761J1410_ENST00000591608.1_Silent_p.F71F	NM_001170635.1|NM_022737.2	NP_001164106.1|NP_073574.2																					GTGCCTTTTTCCCTGCACCAC	0.657000													13	21					0	0	1	0	0
HHIP	64399	broad.mit.edu	37	4	145568084	145568084	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:145568084G>A	ENST00000296575.3	+	1	912	c.257G>A	c.(256-258)gGg>gAg	p.G86E	HHIP-AS1_ENST00000512359.1_RNA|HHIP_ENST00000434550.2_Missense_Mutation_p.G86E	NM_022475.2	NP_071920.1	Q96QV1	HHIP_HUMAN	hedgehog interacting protein	86						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	33	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		GACAGCCCGGGGCTAGGGCGC	0.632000													16	63					0	0	1	0	0
EDIL3	10085	broad.mit.edu	37	5	83402469	83402469	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:83402469G>A	ENST00000296591.5	-	6	1067	c.649C>T	c.(649-651)Cag>Tag	p.Q217*	EDIL3_ENST00000380138.3_Nonsense_Mutation_p.Q207*	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	217	F5/8 type C 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		TCTGTTACCTGAATCCACGGC	0.393000													24	56					0	0	1	0	0
GRIK3	2899	broad.mit.edu	37	1	37267588	37267588	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:37267588C>T	ENST00000373091.3	-	16	2640	c.2624G>A	c.(2623-2625)cGa>cAa	p.R875Q		NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	875					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	GTGCTTGACTCGACGCTGGCA	0.592000													8	62					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248308966	248308966	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:248308966G>A	ENST00000366476.1	+	1	517	c.517G>A	c.(517-519)Gaa>Aaa	p.E173K		NM_001004690.1	NP_001004690.1	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M, member 5	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.E173K(1)		NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			TGGGTCTCGGGAAATAGCCCA	0.428000													213	137					0	0	1	0	0
EEFSEC	60678	broad.mit.edu	37	3	127965702	127965702	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:127965702A>T	ENST00000254730.6	+	2	394	c.340A>T	c.(340-342)Atg>Ttg	p.M114L	EEFSEC_ENST00000483457.1_Missense_Mutation_p.M114L	NM_021937.3	NP_068756.2	P57772	SELB_HUMAN	eukaryotic elongation factor, selenocysteine-tRNA-specific	114						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			NS(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)	25						TGATCTGATGATGCTGGTCAT	0.542000													94	136					0	0	1	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130343515	130343515	+	Silent	SNP	C	C	T	rs143168028		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:130343515C>T	ENST00000299164.2	+	8	2652	c.2652C>T	c.(2650-2652)ccC>ccT	p.P884P		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	884	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		CCCATCGGCCCGTGGAGACAC	0.726000													24	35					0	0	1	0	0
ADAMTS18	170692	broad.mit.edu	37	16	77401558	77401558	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:77401558G>A	ENST00000282849.5	-	4	976	c.558C>T	c.(556-558)gcC>gcT	p.A186A	ADAMTS18_ENST00000567121.1_5'UTR	NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	186					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TGTGTTCCTGGGCCAGAAGCT	0.493000													26	37					0	0	1	0	0
MMP19	4327	broad.mit.edu	37	12	56231153	56231153	+	Silent	SNP	G	G	A	rs139275281		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:56231153G>A	ENST00000394182.1	-	4	335	c.336C>T	c.(334-336)tcC>tcT	p.S112S	MMP19_ENST00000409200.3_3'UTR|MMP19_ENST00000322569.4_Silent_p.S398S|MMP19_ENST00000548629.1_Silent_p.S375S			Q99542	MMP19_HUMAN	matrix metallopeptidase 19	398					angiogenesis|cell differentiation|collagen catabolic process|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(2)|skin(2)	26						GCCAGTACCCGGAGCCCTGGA	0.612000													40	35					0	0	1	0	0
SMTNL2	342527	broad.mit.edu	37	17	4496433	4496433	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:4496433G>A	ENST00000389313.4	+	3	764	c.697G>A	c.(697-699)Gag>Aag	p.E233K	SMTNL2_ENST00000338859.4_Missense_Mutation_p.E89K	NM_001114974.1	NP_001108446.1	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2	233										breast(1)|endometrium(9)|kidney(1)|lung(1)|skin(1)	13				READ - Rectum adenocarcinoma(115;0.0325)		AAGCCCCAGCGAGGTCATCAC	0.652000													29	10					0	0	1	0	0
FSTL5	56884	broad.mit.edu	37	4	163032490	163032490	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:163032490C>T	ENST00000306100.5	-	2	495	c.59G>A	c.(58-60)gGa>gAa	p.G20E	FSTL5_ENST00000379164.4_Missense_Mutation_p.G20E|FSTL5_ENST00000427802.2_Missense_Mutation_p.G20E|FSTL5_ENST00000536695.1_Missense_Mutation_p.G20E	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	20						extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		GGTTGGCCTTCCTTCCGACTC	0.403000													43	33					0	0	1	0	0
OR5H2	79310	broad.mit.edu	37	3	98002430	98002430	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:98002430G>A	ENST00000355273.2	+	1	699	c.699G>A	c.(697-699)aaG>aaA	p.K233K	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005482.1	NP_001005482.1	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H, member 2	233					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						TCCTAAAAAAGAAGTCTGTTA	0.373000													14	26					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179640866	179640866	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179640866C>T	ENST00000589042.1	-	28	5949	c.5725G>A	c.(5725-5727)Gaa>Aaa	p.E1909K	TTN_ENST00000342992.6_Missense_Mutation_p.E1909K|TTN_ENST00000591111.1_Missense_Mutation_p.E1909K|TTN_ENST00000360870.5_Missense_Mutation_p.E1909K|TTN_ENST00000460472.2_Missense_Mutation_p.E1863K|TTN_ENST00000342175.6_Missense_Mutation_p.E1863K|TTN_ENST00000359218.5_Missense_Mutation_p.E1863K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	1627	Ig-like 9.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCTTCACTTCACCTGTGTCA	0.458000													80	135					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50209163	50209163	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:50209163C>T	ENST00000284509.6	-	20	2250	c.2109G>A	c.(2107-2109)ggG>ggA	p.G703G	ATP8B4_ENST00000559829.1_Silent_p.G703G	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	703					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		CAGCATTATTCCCTGCTATCA	0.448000													7	37					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3200941	3200941	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:3200941G>A	ENST00000602557.1	-	24	4064	c.3509C>T	c.(3508-3510)cCa>cTa	p.P1170L	CSMD1_ENST00000602723.1_Missense_Mutation_p.P1170L|CSMD1_ENST00000520002.1_Missense_Mutation_p.P1170L|CSMD1_ENST00000542608.1_Missense_Mutation_p.P1169L|CSMD1_ENST00000400186.3_Missense_Mutation_p.P1170L|CSMD1_ENST00000539096.1_Missense_Mutation_p.P1169L|CSMD1_ENST00000537824.1_Missense_Mutation_p.P1169L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1170	CUB 7.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CGTGCCCAGTGGACGTGAGGA	0.438000													15	26					0	0	1	0	0
PRDM1	639	broad.mit.edu	37	6	106553490	106553490	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:106553490G>A	ENST00000369096.4	+	5	1689	c.1455G>A	c.(1453-1455)agG>agA	p.R485R	PRDM1_ENST00000369089.3_Silent_p.R351R|PRDM1_ENST00000369091.2_Silent_p.R449R	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	485					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		AGCATCCCAGGGAGGTGCTTG	0.687000			"""D, N, Mis, F, S"""		DLBCL								47	72					0	0	1	0	0
POTEF	728378	broad.mit.edu	37	2	130832362	130832362	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:130832362C>T	ENST00000357462.5	-	15	2776	c.2683G>A	c.(2683-2685)Gag>Aag	p.E895K	POTEF_ENST00000409914.2_Missense_Mutation_p.E895K			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	895	Actin-like.					cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						TAGCCATGCTCGGTGAGGATC	0.587000													58	21					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	T	C	rs11554290		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:115256529T>C	ENST00000369535.4	-	3	435	c.182A>G	c.(181-183)cAa>cGa	p.Q61R		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(817)|p.Q61L(175)|p.Q61P(23)|p.Q61K(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(C3A_LIVER)|Q61L(HEPG2_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MELJUSO_SKIN)|Q61L(MHHES1_BONE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(HT1197_URINARY_TRACT)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KU1919_URINARY_TRACT)|Q61R(NCIH2347_LUNG)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(SKMEL2_SKIN)|Q61R(SW1271_LUNG)|Q61R(TT2609C02_THYROID)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			120	64					0	0	1	0	0
BMS1P20	96610	broad.mit.edu	37	22	22661366	22661366	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:22661366G>A	ENST00000426066.1	+	0	360					NR_027293.1																						CAACAGCGAGGGAAATGTTGG	0.507000													4	48					0	0	1	0	0
OR2L13	284521	broad.mit.edu	37	1	248263418	248263418	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:248263418G>A	ENST00000366478.2	+	3	1078	c.741G>A	c.(739-741)gtG>gtA	p.V247V	OR2L13_ENST00000358120.2_Silent_p.V247V	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	247					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			TAACTGTAGTGATCTTTTACT	0.458000													51	30					0	0	1	0	0
LAMB1	3912	broad.mit.edu	37	7	107580511	107580511	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:107580511G>A	ENST00000393561.1	-	23	3940	c.3756C>T	c.(3754-3756)agC>agT	p.S1252S	LAMB1_ENST00000222399.6_Silent_p.S1228S			P07942	LAMB1_HUMAN	laminin, beta 1	1228	Domain II.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent	p.S1228S(1)		NS(3)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(37)|ovary(6)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)	82					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTTTTATCTCGCTGACTTTCC	0.517000													45	59					0	0	1	0	0
SCNN1G	6340	broad.mit.edu	37	16	23221074	23221074	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:23221074G>A	ENST00000300061.2	+	7	1224	c.1081G>A	c.(1081-1083)Gag>Aag	p.E361K	CTC-391G2.1_ENST00000563471.1_RNA	NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	361					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	ATTGCAGACAGAGTCCTTCAA	0.602000													30	56					0	0	1	0	0
SLC4A8	9498	broad.mit.edu	37	12	51853873	51853873	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:51853873G>A	ENST00000453097.2	+	8	1211	c.994G>A	c.(994-996)Gaa>Aaa	p.E332K	SLC4A8_ENST00000514353.3_Missense_Mutation_p.E279K|SLC4A8_ENST00000394856.1_Missense_Mutation_p.E279K|SLC4A8_ENST00000535225.2_Missense_Mutation_p.E279K|SLC4A8_ENST00000358657.3_Missense_Mutation_p.E359K	NM_001039960.2|NM_001258401.2	NP_001035049.1|NP_001245330.1	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate cotransporter, member 8	332					bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(18)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(2)|urinary_tract(5)	55				BRCA - Breast invasive adenocarcinoma(357;0.15)		AGGCCTAACAGAAGTGCCAAT	0.443000													26	112					0	0	1	0	0
PM20D1	148811	broad.mit.edu	37	1	205801747	205801747	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:205801747C>T	ENST00000367136.4	-	11	1308	c.1264G>A	c.(1264-1266)Gaa>Aaa	p.E422K	PM20D1_ENST00000460624.1_5'UTR	NM_152491.4	NP_689704.4	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1	422						extracellular region	metal ion binding|peptidase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)	28	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			ATATTGACTTCCGGGAAGACG	0.577000													14	70					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133539526	133539526	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:133539526C>T	ENST00000409261.1	-	14	5231	c.4858G>A	c.(4858-4860)Gaa>Aaa	p.E1620K	NCKAP5_ENST00000317721.6_Missense_Mutation_p.E1620K|NCKAP5_ENST00000473859.1_5'UTR|NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1620							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TTCAAGAGTTCCGTCATGAAG	0.448000													18	41					0	0	1	0	0
FLG2	388698	broad.mit.edu	37	1	152326973	152326973	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:152326973C>T	ENST00000388718.5	-	3	3361	c.3289G>A	c.(3289-3291)Gga>Aga	p.G1097R	FLG-AS1_ENST00000392688.2_RNA|FLG-AS1_ENST00000445097.1_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1097	Ser-rich.						calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GATGTCTGTCCTGAATTTGAC	0.488000													103	399					0	0	1	0	0
FTHL17	53940	broad.mit.edu	37	X	31090062	31090062	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:31090062G>A	ENST00000359202.3	-	1	108	c.9C>T	c.(7-9)acC>acT	p.T3T		NM_031894.2	NP_114100.1	Q9BXU8	FHL17_HUMAN	ferritin, heavy polypeptide-like 17	3					cellular iron ion homeostasis|iron ion transport		ferric iron binding|oxidoreductase activity			endometrium(2)|large_intestine(2)|liver(1)|lung(13)|prostate(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	23						ACGGCTGGGCGGTGGCCATGG	0.632000													14	18					0	0	1	0	0
TENM3	55714	broad.mit.edu	37	4	183600989	183600989	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:183600989G>A	ENST00000511685.1	+	8	1620	c.1497G>A	c.(1495-1497)ggG>ggA	p.G499G	TENM3_ENST00000406950.2_Silent_p.G499G					teneurin transmembrane protein 3																		ATAATGATGGGAAAAATGCAG	0.448000													4	18					0	0	1	0	0
ITGAM	3684	broad.mit.edu	37	16	31286951	31286951	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:31286951C>T	ENST00000544665.3	+	9	1011	c.940C>T	c.(940-942)Cag>Tag	p.Q314*	ITGAM_ENST00000287497.8_Nonsense_Mutation_p.Q314*	NM_000632.3|NM_001145808.1	NP_000623.2|NP_001139280.1	P11215	ITAM_HUMAN	integrin, alpha M (complement component 3 receptor 3 subunit)	314	VWFA.				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration	integrin complex	glycoprotein binding|receptor activity			endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(1)|prostate(4)|skin(1)	56						TCACGTGTTCCAGGTGAATAA	0.527000													14	34					0	0	1	0	0
BCL11B	64919	broad.mit.edu	37	14	99641075	99641075	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:99641075C>T	ENST00000345514.2	-	3	2151	c.1885G>A	c.(1885-1887)Gcg>Acg	p.A629T	BCL11B_ENST00000443726.2_Missense_Mutation_p.A506T|BCL11B_ENST00000357195.3_Missense_Mutation_p.A700T	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	700	Gly-rich.					nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		GGGATGAGCGCGGCGGGCGGC	0.706000			T	TLX3	T-ALL								26	10					0	0	1	0	0
TIAM1	7074	broad.mit.edu	37	21	32502614	32502614	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:32502614G>A	ENST00000286827.3	-	26	4433	c.3962C>T	c.(3961-3963)tCc>tTc	p.S1321F	TIAM1_ENST00000541036.1_Missense_Mutation_p.S1261F	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	1321	PH 2.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						CTCATAAATGGAAAGCCTGTG	0.527000													62	75					0	0	1	0	0
CIB3	117286	broad.mit.edu	37	19	16275658	16275658	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:16275658C>T	ENST00000269878.4	-	5	462	c.413G>A	c.(412-414)gGg>gAg	p.G138E	CIB3_ENST00000541493.1_5'UTR|CIB3_ENST00000379859.3_Missense_Mutation_p.G89E	NM_054113.2	NP_473454.1	Q96Q77	CIB3_HUMAN	calcium and integrin binding family member 3	138	EF-hand 2.						calcium ion binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	16						ACTCAGCCCCCCCCGCGTCAG	0.577000													32	54					0	0	1	0	0
C5AR1	728	broad.mit.edu	37	19	47823882	47823882	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:47823882C>T	ENST00000355085.3	+	2	870	c.848C>T	c.(847-849)tCc>tTc	p.S283F		NM_001736.3	NP_001727.1	P21730	C5AR_HUMAN	complement component 5a receptor 1	283					activation of MAPK activity|activation of phospholipase C activity|cellular defense response|elevation of cytosolic calcium ion concentration|immune response|sensory perception of chemical stimulus	integral to plasma membrane	C5a anaphylatoxin receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(11)|ovary(2)|prostate(1)|skin(1)	20		all_cancers(25;2e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;0.000267)|OV - Ovarian serous cystadenocarcinoma(262;0.000618)|Epithelial(262;0.0142)|GBM - Glioblastoma multiforme(486;0.0242)		AAGCTGGACTCCCTGTGTGTC	0.567000													47	50					0	0	1	0	0
MIR143	406935	broad.mit.edu	37	5	148808503	148808503	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:148808503C>T	ENST00000385300.1	+	0	23					NR_029684.1																						GTCTCCCAGCCTGAGGTGCAG	0.612000													8	15					0	0	1	0	0
OR6C68	403284	broad.mit.edu	37	12	55887086	55887086	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:55887086C>T	ENST00000379662.1	+	1	940	c.940C>T	c.(940-942)Cgt>Tgt	p.R314C	OR6C68_ENST00000548615.1_Missense_Mutation_p.R309C|RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000556750.1_RNA			A6NDL8	O6C68_HUMAN	olfactory receptor, family 6, subfamily C, member 68	309					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	15						AATTGCATTTCGTTTAAAAAA	0.279000													5	9					0	0	1	0	0
CNR2	1269	broad.mit.edu	37	1	24201229	24201229	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:24201229C>T	ENST00000536471.1	-	3	1137	c.879G>A	c.(877-879)atG>atA	p.M293I	CNR2_ENST00000374472.4_Missense_Mutation_p.M293I			P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	293					behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(9)|pancreas(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(2)	26		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	CAGGGTTGACCATGGAGTTGA	0.582000													15	89					0	0	1	0	0
SIGLEC16	400709	broad.mit.edu	37	19	50473222	50473222	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:50473222G>A	ENST00000602139.1	+	0	223									sialic acid binding Ig-like lectin 16 (gene/pseudogene)											endometrium(2)|kidney(2)|lung(6)	10						TTCAAAGGATGGACCAGCCCA	0.602000													19	45					0	0	1	0	0
TAS2R38	5726	broad.mit.edu	37	7	141673385	141673385	+	Silent	SNP	G	G	A	rs144536521		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:141673385G>A	ENST00000547270.1	-	1	188	c.105C>T	c.(103-105)ttC>ttT	p.F35F		NM_176817.4	NP_789787.4	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	35					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			NS(2)|breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)|stomach(1)	21	Melanoma(164;0.0171)					CCAAGAAAACGAAGGCATTGG	0.483000													27	49					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110516651	110516651	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:110516651C>T	ENST00000378402.5	+	68	11028	c.10924C>T	c.(10924-10926)Cat>Tat	p.H3642Y		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	3642					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GCATCCAATCCATGTGAAGAA	0.289000										HNSCC(38;0.096)			9	6					0	0	1	0	0
SHANK2	22941	broad.mit.edu	37	11	70319045	70319045	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:70319045C>T	ENST00000338508.4	-	33	5481	c.5482G>A	c.(5482-5484)Gat>Aat	p.D1828N	SHANK2_ENST00000449833.2_Missense_Mutation_p.D1232N|SHANK2_ENST00000409161.1_Missense_Mutation_p.D1231N|SHANK2_ENST00000423696.2_Missense_Mutation_p.D1448N			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1448					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			ACCCCAAGATCGATGAGGTCC	0.502000													96	115					0	0	1	0	0
CLSTN2	64084	broad.mit.edu	37	3	140282931	140282931	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:140282931G>A	ENST00000458420.3	+	16	2801	c.2611G>A	c.(2611-2613)Gaa>Aaa	p.E871K		NM_022131.2	NP_071414.2	Q9H4D0	CSTN2_HUMAN	calsyntenin 2	871					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|liver(1)|lung(42)|pancreas(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	87						GGCTGCCAAGGAATCTGAGAT	0.577000										HNSCC(16;0.037)			49	80					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83128806	83128806	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:83128806A>C	ENST00000329312.4	+	4	1127	c.1090A>C	c.(1090-1092)Aag>Cag	p.K364Q		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	364					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						aaaggacacaaagaaGTACCC	0.348000													6	3					0	0	1	0	0
DIAPH2	1730	broad.mit.edu	37	X	96369745	96369745	+	Silent	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:96369745A>G	ENST00000324765.8	+	21	2717	c.2370A>G	c.(2368-2370)ttA>ttG	p.L790L	DIAPH2_ENST00000355827.4_Silent_p.L790L|DIAPH2_ENST00000373049.4_Silent_p.L790L|DIAPH2_ENST00000373054.4_Silent_p.L786L|DIAPH2_ENST00000373061.3_Silent_p.L790L			O60879	DIAP2_HUMAN	diaphanous-related formin 2	790	FH2.				cell differentiation|cytokinesis|multicellular organismal development|oogenesis	cytosol|early endosome|Golgi apparatus|mitochondrion|nucleolus	receptor binding|Rho GTPase binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	51						TGAAAATGTTACAGCCTCGTC	0.358000													15	1					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140502436	140502436	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140502436G>A	ENST00000194152.1	+	1	856	c.856G>A	c.(856-858)Gaa>Aaa	p.E286K		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		286	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCATCAGATGAAATTAAACA	0.343000													23	85					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84526394	84526394	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:84526394G>A	ENST00000360700.4	+	10	2870	c.1984G>A	c.(1984-1986)Gat>Aat	p.D662N	ZNF711_ENST00000276123.3_Missense_Mutation_p.D616N|ZNF711_ENST00000395402.1_Missense_Mutation_p.D624N|ZNF711_ENST00000373165.3_Missense_Mutation_p.D616N|ZNF711_ENST00000542798.1_Missense_Mutation_p.D458N			Q9Y462	ZN711_HUMAN	zinc finger protein 711	616					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						CCATACTAAGGATTTTCCTCA	0.408000													12	5					0	0	1	0	0
FGF6	2251	broad.mit.edu	37	12	4553335	4553335	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:4553335G>A	ENST00000228837.2	-	2	457	c.414C>T	c.(412-414)ttC>ttT	p.F138F		NM_020996.1	NP_066276.2	P10767	FGF6_HUMAN	fibroblast growth factor 6	138					angiogenesis|cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	growth factor activity	p.F138F(1)		NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20			Colorectal(7;0.00165)|COAD - Colon adenocarcinoma(12;0.0229)			TCATGGCAACGAAGAGGGCAC	0.517000													19	12					0	0	1	0	0
PPP2R2C	5522	broad.mit.edu	37	4	6335388	6335388	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:6335388C>T	ENST00000335585.5	-	7	884	c.861G>A	c.(859-861)gtG>gtA	p.V287V	PPP2R2C_ENST00000382599.4_Silent_p.V287V|PPP2R2C_ENST00000515571.1_Silent_p.V270V|PPP2R2C_ENST00000506140.1_Silent_p.V280V|PPP2R2C_ENST00000507294.1_Silent_p.V280V	NM_181876.2	NP_870991.1	Q9Y2T4	2ABG_HUMAN	protein phosphatase 2, regulatory subunit B, gamma	287					signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	28						GGCTGAACTTCACGTCGGACA	0.557000											OREG0016071	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	48					0	0	1	0	0
FSTL4	23105	broad.mit.edu	37	5	132535015	132535015	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:132535015G>A	ENST00000265342.7	-	16	2550	c.2301C>T	c.(2299-2301)tcC>tcT	p.S767S	CTB-49A3.2_ENST00000509051.1_RNA	NM_015082.1	NP_055897.1	Q6MZW2	FSTL4_HUMAN	follistatin-like 4	767						extracellular region	calcium ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(8)|skin(2)|upper_aerodigestive_tract(1)	23		all_cancers(142;0.244)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CCTTCCCCGTGGACAGCTCCA	0.592000													24	14					0	0	1	0	0
EZR	7430	broad.mit.edu	37	6	159206584	159206584	+	Missense_Mutation	SNP	G	G	A	rs11550707		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:159206584G>A	ENST00000367075.3	-	5	392	c.224C>T	c.(223-225)cCc>cTc	p.P75L	EZR_ENST00000337147.7_Missense_Mutation_p.P75L|EZR_ENST00000392177.4_Missense_Mutation_p.P43L|EZR_ENST00000476189.1_5'UTR	NM_001111077.1	NP_001104547.1	P15311	EZRI_HUMAN	ezrin	75	FERM.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding		EZR/ROS1(4)	breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(2)|lung(1)|ovary(1)|prostate(2)	15		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		GAACTGGAGGGGATTCTCCTT	0.542000			T	ROS1	NSCLC								20	55					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31294238	31294238	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:31294238G>A	ENST00000265071.2	+	3	663	c.398G>A	c.(397-399)aGa>aAa	p.R133K	CDH6_ENST00000514738.1_Missense_Mutation_p.R78K	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	133	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GCTATAAACAGAAGGACAGGG	0.458000													40	121					0	0	1	0	0
PTBP2	58155	broad.mit.edu	37	1	97250670	97250670	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:97250670C>T	ENST00000236228.6	+	8	846	c.764C>T	c.(763-765)tCc>tTc	p.S255F	PTBP2_ENST00000394184.3_Missense_Mutation_p.S266F|PTBP2_ENST00000370198.1_Missense_Mutation_p.S255F|PTBP2_ENST00000370197.1_Missense_Mutation_p.S255F|PTBP2_ENST00000426398.2_Missense_Mutation_p.S255F|PTBP2_ENST00000482253.1_3'UTR|PTBP2_ENST00000541987.1_Missense_Mutation_p.S224F	NM_021190.2	NP_067013.1	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	255	RRM 2.						nucleotide binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|skin(1)	26		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		ATTGATTTTTCCAAACTTGTG	0.358000													41	14					0	0	1	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1983779	1983779	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:1983779C>T	ENST00000382722.5	-	18	2231	c.1869G>A	c.(1867-1869)atG>atA	p.M623I	CACNA2D4_ENST00000539048.2_5'UTR|CACNA2D4_ENST00000586184.1_Missense_Mutation_p.M623I|CACNA2D4_ENST00000587995.1_Missense_Mutation_p.M598I|CACNA2D4_ENST00000588077.1_Missense_Mutation_p.M559I|CACNA2D4_ENST00000585732.1_Intron|CACNA2D4_ENST00000585708.1_Missense_Mutation_p.M559I	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	623						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		CCCCTTTATCCATCGGAACCT	0.488000													16	13					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122768941	122768941	+	Missense_Mutation	SNP	C	C	T	rs138989506	by1000genomes	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:122768941C>T	ENST00000194130.2	-	10	1130	c.1091G>A	c.(1090-1092)cGa>cAa	p.R364Q	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	364						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	TCCGGGGTCTCGACTAAACCA	0.418000													13	20					0	0	1	0	0
ATAD3A	55210	broad.mit.edu	37	1	1455959	1455959	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:1455959C>T	ENST00000378755.5	+	7	950	c.856C>T	c.(856-858)Cgt>Tgt	p.R286C	ATAD3A_ENST00000378756.3_Missense_Mutation_p.R238C|ATAD3A_ENST00000536055.1_Missense_Mutation_p.R159C	NM_018188.3	NP_060658.3	Q9NVI7	ATD3A_HUMAN	ATPase family, AAA domain containing 3A	286							ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(4)|kidney(6)|large_intestine(1)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	20	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;1.12e-36)|OV - Ovarian serous cystadenocarcinoma(86;2.18e-22)|Colorectal(212;0.000164)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00233)|BRCA - Breast invasive adenocarcinoma(365;0.00469)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0347)|Lung(427;0.147)		GGAAGGATTCCGTGCCTTTGT	0.587000													67	25					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50535074	50535074	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:50535074C>T	ENST00000267845.3	-	12	1774	c.1372G>A	c.(1372-1374)Gat>Aat	p.D458N	HDC_ENST00000543581.1_Missense_Mutation_p.D425N	NM_002112.3	NP_002103.2	P19113	DCHS_HUMAN	histidine decarboxylase	458					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	AGGATGTCATCCCTAGTGGTA	0.507000													28	26					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	13072164	13072164	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:13072164G>A	ENST00000316609.5	-	6	1756	c.1468C>T	c.(1468-1470)Cat>Tat	p.H490Y	DLC1_ENST00000276297.4_Intron|DLC1_ENST00000512044.2_Intron			Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	0	SAM.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						CCAGCAACATGGAAAAGCCTC	0.458000													21	85					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70897925	70897925	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:70897925C>T	ENST00000322773.4	+	47	3105	c.3003C>T	c.(3001-3003)ggC>ggT	p.G1001G	COL19A1_ENST00000393344.1_Silent_p.G623G	NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	1001	Triple-helical region 5 (COL5).				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						GCCCTCCAGGCTCTCCAGGCA	0.552000													9	35					0	0	1	0	0
ABCB5	340273	broad.mit.edu	37	7	20762706	20762706	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:20762706C>T	ENST00000404938.2	+	21	3141	c.2489C>T	c.(2488-2490)tCc>tTc	p.S830F	ABCB5_ENST00000258738.6_Missense_Mutation_p.S385F	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	385					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						GTTATCATTTCCTTTATATAT	0.413000													37	57					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9069839	9069839	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:9069839C>T	ENST00000397910.4	-	3	17810	c.17607G>A	c.(17605-17607)ggG>ggA	p.G5869G		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5871	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGAGATAGTCCCTATAGGAC	0.502000													52	66					0	0	1	0	0
RNF148	378925	broad.mit.edu	37	7	122342649	122342649	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:122342649G>A	ENST00000434824.1	-	1	372	c.156C>T	c.(154-156)atC>atT	p.I52I	CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000412584.2_Intron|CADPS2_ENST00000313070.7_Intron|CADPS2_ENST00000449022.2_Intron|RNF148_ENST00000447240.1_Intron	NM_198085.1	NP_932351.1	Q8N7C7	RN148_HUMAN	ring finger protein 148	52						integral to membrane	zinc ion binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(7)	16						ATTCCGATGTGATCTCATTTC	0.448000													16	23					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140572443	140572443	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140572443C>T	ENST00000239446.4	+	1	502	c.318C>T	c.(316-318)ttC>ttT	p.F106F		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		106	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCTGTATTTCCAAATTTTAA	0.448000													16	32					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26166140	26166140	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:26166140C>T	ENST00000335473.7	+	5	1826	c.1576C>T	c.(1576-1578)Ctt>Ttt	p.L526F	MYO18B_ENST00000407587.2_Missense_Mutation_p.L526F|MYO18B_ENST00000536101.1_Missense_Mutation_p.L526F	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	526						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TGGATTTACTCTTGGTAAGTA	0.488000													32	36					0	0	1	0	0
ZDHHC13	54503	broad.mit.edu	37	11	19197496	19197496	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:19197496C>T	ENST00000446113.2	+	17	1979	c.1858C>T	c.(1858-1860)Cgc>Tgc	p.R620C	ZDHHC13_ENST00000399351.3_Missense_Mutation_p.R490C	NM_019028.2	NP_061901.2	Q8IUH4	ZDH13_HUMAN	zinc finger, DHHC-type containing 13	620					positive regulation of I-kappaB kinase/NF-kappaB cascade	Golgi-associated vesicle membrane|integral to membrane	magnesium ion transmembrane transporter activity|palmitoyltransferase activity|signal transducer activity|zinc ion binding			NS(1)|kidney(1)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	6						GAAGGTTCTTCGCTCAGTATG	0.423000													42	96					0	0	1	0	0
ARHGEF37	389337	broad.mit.edu	37	5	148996174	148996174	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:148996174C>T	ENST00000333677.6	+	5	666	c.503C>T	c.(502-504)cCt>cTt	p.P168L		NM_001001669.2	NP_001001669.2	A1IGU5	ARH37_HUMAN	Rho guanine nucleotide exchange factor (GEF) 37	168	DH.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(5)|lung(6)|ovary(1)|prostate(2)|stomach(3)	17						CTGGTAATTCCTCTGCAGAGG	0.557000													9	29					0	0	1	0	0
CA5A	763	broad.mit.edu	37	16	87938468	87938468	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:87938468T>A	ENST00000309893.2	-	3	448	c.383A>T	c.(382-384)cAa>cTa	p.Q128L		NM_001739.1	NP_001730.1	P35218	CAH5A_HUMAN	carbonic anhydrase VA, mitochondrial	128					one-carbon metabolic process	mitochondrial matrix	carbonate dehydratase activity|zinc ion binding			large_intestine(4)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	16				BRCA - Breast invasive adenocarcinoma(80;0.0513)		GAAGTGAAATTGCTTCAGTCT	0.532000													56	81					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115383374	115383374	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:115383374C>T	ENST00000369358.4	-	23	2639	c.2395G>A	c.(2395-2397)Gaa>Aaa	p.E799K	NRAP_ENST00000369360.3_Missense_Mutation_p.E764K|NRAP_ENST00000359988.3_Missense_Mutation_p.E791K|NRAP_ENST00000360478.3_Missense_Mutation_p.E756K			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	791						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TTCTGGTTTTCCCAGCTGCTC	0.493000													43	31					0	0	1	0	0
ZNF264	9422	broad.mit.edu	37	19	57723252	57723252	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:57723252G>A	ENST00000263095.6	+	4	1201	c.787G>A	c.(787-789)Gag>Aag	p.E263K	ZNF264_ENST00000536056.1_Missense_Mutation_p.E263K	NM_003417.4	NP_003408.1	O43296	ZN264_HUMAN	zinc finger protein 264	263					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(8)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	27		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		TGAGTGCATGGAGTGTGGAAA	0.498000													18	57					0	0	1	0	0
TBC1D15	64786	broad.mit.edu	37	12	72316974	72316974	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:72316974C>T	ENST00000550746.1	+	18	2130	c.2066C>T	c.(2065-2067)aCa>aTa	p.T689I	TBC1D15_ENST00000319106.8_Missense_Mutation_p.T680I|TBC1D15_ENST00000485960.2_Missense_Mutation_p.T672I|TBC1D15_ENST00000393309.3_Missense_Mutation_p.T443I	NM_001146213.1|NM_022771.4	NP_001139685.2|NP_073608.4	Q8TC07	TBC15_HUMAN	TBC1 domain family, member 15	689							protein binding|Rab GTPase activator activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(8)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						TGCAGATTAACACCTGCATGA	0.413000													28	60					0	0	1	0	0
ZNF512	84450	broad.mit.edu	37	2	27830724	27830724	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:27830724C>T	ENST00000355467.4	+	10	1032	c.949C>T	c.(949-951)Cca>Tca	p.P317S	ZNF512_ENST00000416005.2_Missense_Mutation_p.P288S|ZNF512_ENST00000413371.2_Missense_Mutation_p.P240S|ZNF512_ENST00000379717.1_Missense_Mutation_p.P316S|RP11-158I13.2_ENST00000505973.1_RNA|ZNF512_ENST00000556601.1_Missense_Mutation_p.P186S			Q96ME7	ZN512_HUMAN	zinc finger protein 512	317					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)					ATCCTTCTTTCCAGAGTCAGG	0.478000													6	27					0	0	1	0	0
HOMER2	9455	broad.mit.edu	37	15	83532943	83532943	+	Silent	SNP	G	G	A	rs11629943		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:83532943G>A	ENST00000304231.8	-	4	555	c.363C>T	c.(361-363)atC>atT	p.I121I	HOMER2_ENST00000450735.2_Silent_p.I121I|HOMER2_ENST00000399166.2_Silent_p.I121I|HOMER2_ENST00000426485.1_Silent_p.I121I	NM_199330.2	NP_955362.1	Q9NSB8	HOME2_HUMAN	homer homolog 2 (Drosophila)	121					metabotropic glutamate receptor signaling pathway	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane				cervix(1)|endometrium(2)|lung(6)	9						TTGAGGTCTCGATTTTCTCCT	0.418000													19	23					0	0	1	0	0
SUPT6H	6830	broad.mit.edu	37	17	27001622	27001622	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:27001622C>T	ENST00000314616.6	+	4	619	c.336C>T	c.(334-336)gtC>gtT	p.V112V	SUPT6H_ENST00000347486.4_Silent_p.V112V	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	112	Asp/Glu-rich.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					GTGTCAAAGTCAAAAGAGGAG	0.468000													30	46					0	0	1	0	0
LCK	3932	broad.mit.edu	37	1	32745777	32745777	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:32745777G>A	ENST00000333070.4	+	12	1483	c.1383G>A	c.(1381-1383)acG>acA	p.T461T	LCK_ENST00000373564.3_Silent_p.T438T|LCK_ENST00000336890.5_Silent_p.T431T	NM_001042771.1	NP_001036236.1	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase	431	Protein kinase.				activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	37		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	TCCTGCTGACGGAAATTGTCA	0.517000			T	TRB@	T-ALL								40	22					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703589	4703589	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:4703589G>A	ENST00000396950.3	-	2	592	c.353C>T	c.(352-354)gCc>gTc	p.A118V		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	118					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		ACGGTCAAAGGCCATGGCCAG	0.532000													23	28					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48201559	48201559	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:48201559C>T	ENST00000394747.1	-	28	4253	c.3904G>A	c.(3904-3906)Gat>Aat	p.D1302N	ABCC11_ENST00000394748.1_Missense_Mutation_p.D1302N|ABCC11_ENST00000565329.1_5'UTR|ABCC11_ENST00000356608.2_Missense_Mutation_p.D1302N|ABCC11_ENST00000353782.5_Missense_Mutation_p.D1264N	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	1302	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GTGGCTTCATCGATAAGGATG	0.542000													54	83					0	0	1	0	0
OPCML	4978	broad.mit.edu	37	11	132812839	132812839	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:132812839C>T	ENST00000331898.7	-	1	727	c.149G>A	c.(148-150)gGg>gAg	p.G50E	OPCML_ENST00000524381.1_Missense_Mutation_p.G43E|OPCML_ENST00000529038.1_Intron|OPCML_ENST00000541867.1_Missense_Mutation_p.G50E|OPCML_ENST00000374778.4_Missense_Mutation_p.G9E	NM_002545.3	NP_002536.1	Q14982	OPCM_HUMAN	opioid binding protein/cell adhesion molecule-like	50	Ig-like C2-type 1.				cell adhesion|neuron recognition	anchored to membrane|integral to plasma membrane	opioid receptor activity			endometrium(5)|kidney(1)|large_intestine(12)|lung(17)|ovary(2)|skin(2)|urinary_tract(8)	47	all_hematologic(175;0.019)	all_cancers(12;5.86e-24)|all_epithelial(12;2.65e-17)|all_lung(97;2.89e-05)|Lung NSC(97;6.16e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0269)|all_neural(223;0.0326)|Esophageal squamous(93;0.129)		all cancers(11;4.61e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.012)		GGCGCTCTCCCCCTGCCGGAC	0.672000													33	71					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	372693	372693	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:372693G>A	ENST00000342640.4	-	5	615	c.573C>T	c.(571-573)tcC>tcT	p.S191S	THEG_ENST00000346878.2_Silent_p.S167S	NM_016585.4	NP_057669.1	Q9P2T0	THEG_HUMAN	theg spermatid protein	191					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACGCGGCGGGACACCGCTA	0.552000													12	34					0	0	1	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762664	130762664	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:130762664G>A	ENST00000392429.1	+	2	3475	c.1097G>A	c.(1096-1098)gGa>gAa	p.G366E	TMEM200A_ENST00000296978.3_Missense_Mutation_p.G366E|TMEM200A_ENST00000545622.1_Missense_Mutation_p.G366E	NM_052913.2	NP_443145.1	Q86VY9	T200A_HUMAN	transmembrane protein 200A	366						integral to membrane				NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		ATGGCTCTCGGACCTGGGGCT	0.522000													13	40					0	0	1	0	0
RNF152	220441	broad.mit.edu	37	18	59483443	59483443	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:59483443G>A	ENST00000312828.3	-	2	1353	c.254C>T	c.(253-255)tCc>tTc	p.S85F		NM_173557.2	NP_775828.1	Q8N8N0	RN152_HUMAN	ring finger protein 152	85					apoptosis|protein K48-linked ubiquitination	integral to membrane|lysosomal membrane	ubiquitin-protein ligase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)	17		Colorectal(73;0.186)				GGTGTGTTCGGAAGTGTGTGG	0.647000													27	38					0	0	1	0	0
SCAF11	9169	broad.mit.edu	37	12	46321331	46321331	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:46321331G>A	ENST00000465950.1	-	1	2417	c.1208C>T	c.(1207-1209)cCt>cTt	p.P403L	SCAF11_ENST00000549162.1_Missense_Mutation_p.P526L|SCAF11_ENST00000369367.3_Missense_Mutation_p.P718L|SCAF11_ENST00000419565.2_Missense_Mutation_p.P718L			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	718					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						ACACTCCATAGGTATCATTTC	0.363000													66	43					0	0	1	0	0
PSG8	440533	broad.mit.edu	37	19	43262158	43262158	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:43262158G>A	ENST00000404209.4	-	3	801	c.705C>T	c.(703-705)ctC>ctT	p.L235L	PSG8_ENST00000600709.1_5'UTR|PSG8_ENST00000401467.2_Intron|PSG8_ENST00000406636.3_Silent_p.L113L|PSG8_ENST00000306511.4_Silent_p.L235L	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	235						extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				ACTCACGGAGGAGATTCAGGG	0.522000													127	202					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31297434	31297434	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:31297434G>A	ENST00000265071.2	+	4	827	c.562G>A	c.(562-564)Gat>Aat	p.D188N	CDH6_ENST00000514738.1_Missense_Mutation_p.D133N	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	188	Cadherin 2.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding	p.D188N(1)		NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						GGATGCAGATGATCCAACATA	0.378000													30	68					0	0	1	0	0
PAN3	255967	broad.mit.edu	37	13	28862219	28862219	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:28862219C>T	ENST00000399613.1	+	17	1946	c.1883C>T	c.(1882-1884)cCc>cTc	p.P628L	PAN3_ENST00000282391.5_Missense_Mutation_p.P516L|PAN3_ENST00000380958.3_Missense_Mutation_p.P828L			Q58A45	PAN3_HUMAN	PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)	828	Interaction with PAN2.|Protein kinase.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity	p.P628L(1)		endometrium(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		GCAGGTGCTCCCTGGATTGAC	0.373000													25	27					0	0	1	0	0
NR5A2	2494	broad.mit.edu	37	1	200017300	200017300	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:200017300C>T	ENST00000367362.3	+	5	710	c.463_splice	c.e5-1	p.A155_splice	NR5A2_ENST00000236914.3_Splice_Site_p.A109_splice|NR5A2_ENST00000544748.1_Splice_Site_p.A83_splice	NM_001276464.1|NM_205860.1	NP_001263393.1|NP_995582.1	O00482	NR5A2_HUMAN	nuclear receptor subfamily 5, group A, member 2	155					embryo development|positive regulation of viral genome replication|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	lipid binding|protein binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	31	Prostate(682;0.19)					CCCCCAACAGCTGTAAGGGCC	0.473000													51	30					0	0	1	0	0
CD33	945	broad.mit.edu	37	19	51729593	51729593	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:51729593C>T	ENST00000436584.2	+	3	400	c.345C>T	c.(343-345)atC>atT	p.I115I	CD33_ENST00000421133.2_Silent_p.I115I|CD33_ENST00000262262.4_Silent_p.I242I|CD33_ENST00000391796.3_Silent_p.I242I			P20138	CD33_HUMAN	CD33 molecule	242	Ig-like V-type.				cell adhesion|cell-cell signaling|negative regulation of cell proliferation	external side of plasma membrane|integral to plasma membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(15)|skin(1)|stomach(1)	24		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000224)|OV - Ovarian serous cystadenocarcinoma(262;0.00468)	Gemtuzumab ozogamicin(DB00056)	CAACTGGTATCTTTCCAGGAG	0.507000													9	37					0	0	1	0	0
BRD9	65980	broad.mit.edu	37	5	889719	889719	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:889719G>A	ENST00000483173.1	-	4	429	c.290C>T	c.(289-291)tCc>tTc	p.S97F	BRD9_ENST00000388890.4_Silent_p.F32F|BRD9_ENST00000323510.4_Silent_p.F32F|BRD9_ENST00000435709.2_Silent_p.F32F|BRD9_ENST00000467963.1_Silent_p.F148F	NM_001009877.2	NP_001009877.2	Q9H8M2	BRD9_HUMAN	bromodomain containing 9	144							nucleic acid binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|pancreas(1)|prostate(3)	29			Epithelial(17;0.00202)|OV - Ovarian serous cystadenocarcinoma(19;0.00353)|all cancers(22;0.00815)|Lung(60;0.185)			GCTGGCGGAGGAAGTGTTCCA	0.478000													27	55					0	0	1	0	0
AMER1	139285	broad.mit.edu	37	X	63410327	63410327	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:63410327G>A	ENST00000330258.3	-	2	3112	c.2840C>T	c.(2839-2841)tCc>tTc	p.S947F	AMER1_ENST00000403336.1_Intron|AMER1_ENST00000374869.3_Intron	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									AGTATAGAGGGAAAGGGGACT	0.587000													14	7					0	0	1	0	0
CHD6	84181	broad.mit.edu	37	20	40052233	40052233	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:40052233G>A	ENST00000373233.3	-	30	4631	c.4454C>T	c.(4453-4455)tCc>tTc	p.S1485F		NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1485					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				GTCCAAACGGGAAATGATGCG	0.443000													87	140					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74477521	74477521	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:74477521G>A	ENST00000394019.2	-	17	1999	c.1602C>T	c.(1600-1602)acC>acT	p.T534T	SLC4A5_ENST00000346834.4_Silent_p.T534T|SLC4A5_ENST00000359484.4_Silent_p.T470T|SLC4A5_ENST00000377632.1_Silent_p.T534T|SLC4A5_ENST00000377634.4_Silent_p.T534T|SLC4A5_ENST00000358683.4_Silent_p.T470T|SLC4A5_ENST00000423644.1_Silent_p.T534T|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000357822.5_Silent_p.T534T|RP11-287D1.3_ENST00000451608.2_3'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	534						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						TGATCGCGTTGGTGATACAGC	0.522000											OREG0014716	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	117					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8609287	8609287	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:8609287C>T	ENST00000338257.8	-	14	1685	c.1418G>A	c.(1417-1419)gGg>gAg	p.G473E		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	473	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						GTCTGCTCCCCCGCCCGTGGC	0.667000													28	30					0	0	1	0	0
GON4L	54856	broad.mit.edu	37	1	155735953	155735953	+	Missense_Mutation	SNP	G	G	A	rs138268831		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:155735953G>A	ENST00000437809.1	-	21	3433	c.3311C>T	c.(3310-3312)tCc>tTc	p.S1104F	GON4L_ENST00000271883.5_Missense_Mutation_p.S1104F|GON4L_ENST00000361040.5_Missense_Mutation_p.S1104F|GON4L_ENST00000471341.1_5'UTR|GON4L_ENST00000368331.1_Missense_Mutation_p.S1104F			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	1104					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					AGGGGCAAGGGAGGGCAGCAT	0.562000													89	46					0	0	1	0	0
LOC101927079	101927079	broad.mit.edu	37	15	22332609	22332609	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:22332609C>T	ENST00000558896.1	+	0	416																											TAGGTCATCTCTCTTTCATTG	0.443000													12	76					0	0	1	0	0
CNGA1	1259	broad.mit.edu	37	4	47939364	47939364	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:47939364G>A	ENST00000402813.3	-	10	1496	c.1354C>T	c.(1354-1356)Cta>Tta	p.L452L	CNGA1_ENST00000358519.4_Silent_p.L383L|CNGA1_ENST00000420489.2_Silent_p.L383L|CNGA1_ENST00000514170.1_Silent_p.L383L|CNGA1_ENST00000544810.1_Silent_p.L383L			P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1	383					response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|urinary_tract(1)	28						ACTCCAATTAGGAAATCAACC	0.423000													37	125					0	0	1	0	0
MYO7A	4647	broad.mit.edu	37	11	76893104	76893104	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:76893104C>T	ENST00000409709.3	+	24	3284	c.3012C>T	c.(3010-3012)ttC>ttT	p.F1004F	MYO7A_ENST00000409619.2_Silent_p.F993F|MYO7A_ENST00000458637.2_Silent_p.F1004F|MYO7A_ENST00000409893.1_Silent_p.F1004F	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	1004					actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						TTGCCAAGTTCGCGGCCACCT	0.607000													39	58					0	0	1	0	0
CDH6	1004	broad.mit.edu	37	5	31317540	31317540	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:31317540C>T	ENST00000265071.2	+	10	1836	c.1571C>T	c.(1570-1572)tCg>tTg	p.S524L	CDH6_ENST00000514738.1_Missense_Mutation_p.S469L	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	524	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						CACCAATTTTCGTTTTCCTTG	0.403000													12	62					0	0	1	0	0
SCG3	29106	broad.mit.edu	37	15	51988145	51988145	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:51988145G>A	ENST00000220478.3	+	8	1345	c.942G>A	c.(940-942)gtG>gtA	p.V314V	SCG3_ENST00000542355.2_Silent_p.V82V	NM_013243.3	NP_037375.2	Q8WXD2	SCG3_HUMAN	secretogranin III	314					platelet activation|platelet degranulation	extracellular region|stored secretory granule				breast(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				all cancers(107;0.00488)		AGATGATGGTGAAATATGGAA	0.313000													23	71					0	0	1	0	0
RPAP3	79657	broad.mit.edu	37	12	48062756	48062756	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:48062756G>A	ENST00000005386.3	-	14	1771	c.1656C>T	c.(1654-1656)ctC>ctT	p.L552L	RPAP3_ENST00000432584.3_Silent_p.L393L|RPAP3_ENST00000380650.4_Silent_p.L518L	NM_024604.2	NP_078880.2	Q9H6T3	RPAP3_HUMAN	RNA polymerase II associated protein 3	552							binding			endometrium(2)|large_intestine(4)|liver(1)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Lung SC(27;0.192)					AATCAGATTCGAGCTGGAACG	0.398000													31	29					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141731546	141731546	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:141731546G>A	ENST00000475668.2	+	13	1591	c.1537G>A	c.(1537-1539)Gaa>Aaa	p.E513K	MGAM_ENST00000549489.2_Missense_Mutation_p.E513K			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	513	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity	p.E513*(2)		cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GTGGACAAAGGAATTTGAGCT	0.368000													25	51					0	0	1	0	0
CCHCR1	54535	broad.mit.edu	37	6	31117976	31117976	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:31117976G>A	ENST00000396268.3	-	8	1417	c.1229C>T	c.(1228-1230)tCc>tTc	p.S410F	CCHCR1_ENST00000480060.1_Intron|CCHCR1_ENST00000376266.5_Missense_Mutation_p.S321F|CCHCR1_ENST00000451521.2_Missense_Mutation_p.S374F|CCHCR1_ENST00000396263.2_Missense_Mutation_p.S321F	NM_001105563.1|NM_001105564.1	NP_001099033.1|NP_001099034.1	Q8TD31	CCHCR_HUMAN	coiled-coil alpha-helical rod protein 1	321					cell differentiation|multicellular organismal development	cytoplasm|nucleus	protein binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(13)|skin(1)	23						AGGCTCCAGGGAATCTGAAGG	0.572000													12	28					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13361447	13361447	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:13361447G>A	ENST00000254508.5	-	37	5281	c.5199C>T	c.(5197-5199)ttC>ttT	p.F1733F		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	1733					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					TCTCCTTTGCGAATGCCAGCA	0.627000													30	50					0	0	1	0	0
CYFIP2	26999	broad.mit.edu	37	5	156742036	156742036	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:156742036C>T	ENST00000347377.6	+	13	1721	c.1290C>T	c.(1288-1290)acC>acT	p.T430T	CYFIP2_ENST00000522463.1_Silent_p.T234T|CYFIP2_ENST00000521420.1_Silent_p.T404T|CYFIP2_ENST00000435847.2_Silent_p.T104T|CYFIP2_ENST00000442283.2_5'UTR|CYFIP2_ENST00000541131.1_Silent_p.T355T|CYFIP2_ENST00000377576.3_Silent_p.T430T|CYFIP2_ENST00000318218.6_Silent_p.T430T	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	430					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTCCTGGCACCGCGGAGGAAT	0.522000													9	7					0	0	1	0	0
ZNF221	7638	broad.mit.edu	37	19	44471168	44471168	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:44471168C>T	ENST00000251269.5	+	6	1842	c.1514C>T	c.(1513-1515)cCt>cTt	p.P505L	ZNF221_ENST00000587682.1_Missense_Mutation_p.P505L|ZNF221_ENST00000592350.1_Missense_Mutation_p.P505L	NM_013359.2	NP_037491.2	Q9UK13	ZN221_HUMAN	zinc finger protein 221	505					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(11)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	30		Prostate(69;0.0352)				GGGGAAAAACCTTTCAAATGT	0.443000													21	32					0	0	1	0	0
C7orf63	79846	broad.mit.edu	37	7	89929369	89929369	+	Silent	SNP	C	C	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:89929369C>A	ENST00000389297.4	+	17	2297	c.2046C>A	c.(2044-2046)atC>atA	p.I682I	C7orf63_ENST00000316089.8_Silent_p.I682I|C7orf63_ENST00000497910.1_Silent_p.I664I	NM_001039706.2|NM_001160138.1	NP_001034795.2|NP_001153610.1	A5D8W1	CG063_HUMAN	chromosome 7 open reading frame 63	682							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|prostate(3)	37						ATGGGAAGATCATTGGTGAGT	0.328000													5	17					1.024e-07	1.02941e-07	1	1	0
ACE	1636	broad.mit.edu	37	17	61562259	61562259	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:61562259C>T	ENST00000577647.1	+	1	76	c.31C>T	c.(31-33)Ccc>Tcc	p.P11S	ACE_ENST00000290863.6_Missense_Mutation_p.P11S|ACE_ENST00000290866.4_Intron|ACE_ENST00000413513.3_Missense_Mutation_p.P11S|ACE_ENST00000490216.2_Missense_Mutation_p.P11S|ACE_ENST00000421982.2_5'UTR|ACE_ENST00000428043.1_Intron			P12821	ACE_HUMAN	angiotensin I converting enzyme	0					arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(5)|kidney(3)|large_intestine(3)|lung(22)|ovary(6)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	51					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TGCAGGACTTCCCAGCCTCCT	0.642000													3	3					0	0	1	0	0
SMG1	23049	broad.mit.edu	37	16	18845580	18845580	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:18845580G>A	ENST00000446231.2	-	50	8923	c.8511C>T	c.(8509-8511)ccC>ccT	p.P2837P	SMG1_ENST00000389467.3_Silent_p.P2837P			Q96Q15	SMG1_HUMAN	SMG1 phosphatidylinositol 3-kinase-related kinase	2837					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(8)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(37)|ovary(1)|skin(1)|stomach(4)|urinary_tract(1)	92						ACGCTTCCATGGGGTTCGGGA	0.438000													6	9					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179482566	179482566	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179482566G>A	ENST00000589042.1	-	253	47736	c.47512C>T	c.(47512-47514)Cga>Tga	p.R15838*	TTN_ENST00000342992.6_Nonsense_Mutation_p.R13270*|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Nonsense_Mutation_p.R14197*|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Nonsense_Mutation_p.R6773*|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Nonsense_Mutation_p.R6965*|TTN_ENST00000359218.5_Nonsense_Mutation_p.R6898*|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	14197	Fibronectin type-III 15.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R6965*(1)|p.R6773*(1)|p.R13270*(1)|p.R6898*(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTCCAATTCGATTTTGGGCT	0.453000													40	69					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84526827	84526827	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:84526827T>C	ENST00000360700.4	+	10	3303	c.2417T>C	c.(2416-2418)cTt>cCt	p.L806P	ZNF711_ENST00000276123.3_Missense_Mutation_p.L760P|ZNF711_ENST00000395402.1_Missense_Mutation_p.L768P|ZNF711_ENST00000373165.3_Missense_Mutation_p.L760P|ZNF711_ENST00000542798.1_Missense_Mutation_p.L602P			Q9Y462	ZN711_HUMAN	zinc finger protein 711	760					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						AAAGAGGCTCTTATGTAATAA	0.378000													9	11					0	0	1	0	0
EXOC2	55770	broad.mit.edu	37	6	549181	549181	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:549181G>A	ENST00000230449.4	-	22	2367	c.2232C>T	c.(2230-2232)atC>atT	p.I744I	EXOC2_ENST00000448181.3_Silent_p.I339I	NM_018303.4	NP_060773.3	Q96KP1	EXOC2_HUMAN	exocyst complex component 2	744					exocytosis|protein transport					breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(9)|liver(1)|lung(16)|ovary(4)|pancreas(1)|prostate(2)	46	Ovarian(93;0.0733)	Breast(5;0.0014)|all_lung(73;0.0697)|all_hematologic(90;0.0897)		OV - Ovarian serous cystadenocarcinoma(45;0.0507)|BRCA - Breast invasive adenocarcinoma(62;0.14)		TTACCTGTGTGATTTTTTCTA	0.413000													40	124					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7982099	7982099	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:7982099G>A	ENST00000328600.2	-	2	1221	c.1060C>T	c.(1060-1062)Cca>Tca	p.P354S		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	354	NACHT.						ATP binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CAAATGCCTGGAACCTGACAC	0.507000													29	40					0	0	1	0	0
TRAPPC11	60684	broad.mit.edu	37	4	184614882	184614882	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:184614882T>C	ENST00000334690.6	+	21	2580	c.2378T>C	c.(2377-2379)tTa>tCa	p.L793S	TRAPPC11_ENST00000357207.4_Missense_Mutation_p.L793S|TRAPPC11_ENST00000512476.1_Missense_Mutation_p.L399S	NM_021942.5	NP_068761.4	Q7Z392	CD041_HUMAN	trafficking protein particle complex 11	793																	ACCGCTGGCTTAAAACCAGGT	0.393000													8	40					0	0	1	0	0
MROH1	727957	broad.mit.edu	37	8	145223308	145223308	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:145223308C>T	ENST00000528919.1	+	3	254	c.133C>T	c.(133-135)Cgt>Tgt	p.R45C	MROH1_ENST00000398656.4_Missense_Mutation_p.R45C|MROH1_ENST00000326134.5_Missense_Mutation_p.R45C|MROH1_ENST00000423230.2_Missense_Mutation_p.R45C|MROH1_ENST00000534366.1_Missense_Mutation_p.R45C	NM_032450.2	NP_115826.2			maestro heat-like repeat family member 1																		GGAGACGCTCCGTGCCTGCGA	0.632000													25	33					0	0	1	0	0
SLC40A1	30061	broad.mit.edu	37	2	190428502	190428502	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:190428502G>A	ENST00000261024.2	-	7	1636	c.1210C>T	c.(1210-1212)Cct>Tct	p.P404S		NM_014585.5	NP_055400.1	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated transporter), member 1	404					anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			endometrium(3)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			TCTTCAAAAGGAGAAACGGAC	0.428000													31	43					0	0	1	0	0
MATN4	8785	broad.mit.edu	37	20	43929563	43929563	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:43929563C>T	ENST00000537548.1	-	7	1220	c.976G>A	c.(976-978)Ggg>Agg	p.G326R	MATN4_ENST00000372753.1_Missense_Mutation_p.G177R|MATN4_ENST00000372754.1_Missense_Mutation_p.G367R|MATN4_ENST00000372756.1_Missense_Mutation_p.G326R|MATN4_ENST00000342716.4_Missense_Mutation_p.G326R|MATN4_ENST00000360607.5_Missense_Mutation_p.G285R|MATN4_ENST00000372751.4_Missense_Mutation_p.G177R|MATN4_ENST00000353917.5_Missense_Mutation_p.G244R			O95460	MATN4_HUMAN	matrilin 4	367	EGF-like 3.					extracellular region	protein binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	27		Myeloproliferative disorder(115;0.0122)				AGTTGCCGCCCCTCGGGGCAC	0.607000													7	44					0	0	1	0	0
TRIM58	25893	broad.mit.edu	37	1	248028152	248028152	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:248028152G>A	ENST00000366481.3	+	3	710	c.662G>A	c.(661-663)cGg>cAg	p.R221Q		NM_015431.3	NP_056246.3	Q8NG06	TRI58_HUMAN	tripartite motif containing 58	221						intracellular	zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(39)|ovary(4)|pancreas(1)|skin(7)|stomach(1)	63	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			AGCAAGAGCCGGCTGGTCCAG	0.692000													7	16					0	0	1	0	0
SNX14	57231	broad.mit.edu	37	6	86257040	86257040	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:86257040G>A	ENST00000314673.3	-	11	1164	c.988C>T	c.(988-990)Cca>Tca	p.P330S	SNX14_ENST00000513865.1_Missense_Mutation_p.P330S|SNX14_ENST00000346348.3_Missense_Mutation_p.P286S|SNX14_ENST00000369627.2_Missense_Mutation_p.P330S|SNX14_ENST00000505648.1_Missense_Mutation_p.P278S|SNX14_ENST00000508980.1_5'UTR	NM_153816.3	NP_722523.1	Q9Y5W7	SNX14_HUMAN	sorting nexin 14	330					cell communication|protein transport	integral to membrane	phosphatidylinositol binding|signal transducer activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(11)|skin(1)	22		all_cancers(76;4.83e-07)|Acute lymphoblastic leukemia(125;3.3e-08)|Prostate(29;2.55e-07)|all_hematologic(105;3.66e-05)|all_epithelial(107;0.000695)|Lung NSC(302;0.197)|all_lung(197;0.24)		BRCA - Breast invasive adenocarcinoma(108;0.0423)		CTTACAGATGGCTTTTTATTT	0.313000													18	16					0	0	1	0	0
WDR93	56964	broad.mit.edu	37	15	90280911	90280911	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:90280911G>A	ENST00000268130.7	+	15	1817	c.1716G>A	c.(1714-1716)tgG>tgA	p.W572*	WDR93_ENST00000444934.2_Nonsense_Mutation_p.W289*|WDR93_ENST00000560294.1_Nonsense_Mutation_p.W544*	NM_020212.1	NP_064597.1	Q6P2C0	WDR93_HUMAN	WD repeat domain 93	572					electron transport chain	mitochondrial inner membrane	oxidoreductase activity, acting on NADH or NADPH			NS(1)|breast(3)|endometrium(2)|kidney(4)|large_intestine(5)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	33	Lung NSC(78;0.0237)|all_lung(78;0.0478)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|BRCA - Breast invasive adenocarcinoma(143;0.128)			AGGTCCCCTGGAAGCCAGTGT	0.542000													31	23					0	0	1	0	0
AKAP13	11214	broad.mit.edu	37	15	86261363	86261363	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:86261363G>A	ENST00000394518.2	+	22	6069	c.5974G>A	c.(5974-5976)Gtg>Atg	p.V1992M	AKAP13_ENST00000361243.2_Missense_Mutation_p.V1996M|AKAP13_ENST00000560579.1_3'UTR|AKAP13_ENST00000394510.2_Missense_Mutation_p.V237M	NM_001270546.1|NM_007200.3	NP_001257475.1|NP_009131.2	Q12802	AKP13_HUMAN	A kinase (PRKA) anchor protein 13	1992	Interaction with ESR1.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(2)|central_nervous_system(4)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(13)|liver(1)|lung(43)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	98						AAAGAAAGATGTGGTCAAACG	0.378000													10	46					0	0	1	0	0
CTIF	9811	broad.mit.edu	37	18	46287844	46287844	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:46287844C>T	ENST00000256413.3	+	9	1450	c.1155C>T	c.(1153-1155)aaC>aaT	p.N385N	CTIF_ENST00000382998.4_Silent_p.N387N	NM_014772.2	NP_055587.1	O43310	CTIF_HUMAN	CBP80/20-dependent translation initiation factor	385	MIF4G.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	31						TGCGGAACAACAGCAGCGACG	0.587000													25	48					0	0	1	0	0
PCDHB2	56133	broad.mit.edu	37	5	140474669	140474669	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140474669G>A	ENST00000194155.4	+	1	443	c.295G>A	c.(295-297)Ggc>Agc	p.G99S		NM_018936.2	NP_061759.1	Q9Y5E7	PCDB2_HUMAN		99	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(22)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGAGCTGTGCGGCCCCACAGA	0.488000													12	58					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	30977214	30977214	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:30977214C>T	ENST00000295055.8	-	9	1059	c.883G>A	c.(883-885)Gaa>Aaa	p.E295K	CAPN13_ENST00000534090.2_Missense_Mutation_p.E295K	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	295	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					TCACAGGTTTCCTCCCACTCC	0.448000													3	15					0	0	1	0	0
SIRPB1	10326	broad.mit.edu	37	20	1585397	1585397	+	Missense_Mutation	SNP	T	T	C	rs148754551	by1000genomes	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:1585397T>C	ENST00000279477.7	-	3	806	c.742A>G	c.(742-744)Acc>Gcc	p.T248A	SIRPB1_ENST00000381605.4_Intron|SIRPB1_ENST00000568365.1_Missense_Mutation_p.T248A|RP4-576H24.4_ENST00000564763.1_Intron|SIRPB1_ENST00000381603.3_Intron	NM_001135844.2	NP_001129316.1	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	248					cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding	p.T248A(5)		central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						CCTCGGATGGTCTCAGACAAG	0.627000													5	39					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2806844	2806844	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:2806844C>T	ENST00000602557.1	-	69	10937	c.10382G>A	c.(10381-10383)gGa>gAa	p.G3461E	CSMD1_ENST00000602723.1_Missense_Mutation_p.G3284E|CSMD1_ENST00000520002.1_Missense_Mutation_p.G3461E|CSMD1_ENST00000542608.1_Missense_Mutation_p.G3283E|CSMD1_ENST00000400186.3_Missense_Mutation_p.G3284E|CSMD1_ENST00000537824.1_Missense_Mutation_p.G3460E			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	3461						integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTTAAATTTTCCAAAGTCTTT	0.328000													7	14					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142643326	142643326	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:142643326G>A	ENST00000355265.2	-	11	1756	c.1282C>T	c.(1282-1284)Cgt>Tgt	p.R428C	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	428					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					AAGGCCTCACGAACAAACAAA	0.592000													10	25					0	0	1	0	0
AHNAK2	113146	broad.mit.edu	37	14	105406981	105406981	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:105406981G>A	ENST00000333244.5	-	7	14926	c.14807C>T	c.(14806-14808)cCt>cTt	p.P4936L	AHNAK2_ENST00000557457.1_Intron	NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	4936						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			GGCTTCTCCAGGGGCCACTAC	0.562000													30	8					0	0	1	0	0
KLHL13	90293	broad.mit.edu	37	X	117035816	117035816	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:117035816C>T	ENST00000371876.1	-	5	3728	c.1307G>A	c.(1306-1308)gGa>gAa	p.G436E	KLHL13_ENST00000262820.3_Missense_Mutation_p.G487E|KLHL13_ENST00000371878.1_Missense_Mutation_p.G436E|KLHL13_ENST00000539496.1_Missense_Mutation_p.G490E|KLHL13_ENST00000469946.1_Missense_Mutation_p.G436E|KLHL13_ENST00000545703.1_Missense_Mutation_p.G445E|KLHL13_ENST00000541812.1_Missense_Mutation_p.G471E|KLHL13_ENST00000540167.1_Missense_Mutation_p.G471E|KLHL13_ENST00000371882.1_Missense_Mutation_p.G436E			Q9P2N7	KLH13_HUMAN	kelch-like family member 13	487					cytokinesis|mitosis|protein ubiquitination	Cul3-RING ubiquitin ligase complex				NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	34						CATCACTCCTCCATACACAGT	0.353000													31	8					0	0	1	0	0
ACTR3B	57180	broad.mit.edu	37	7	152497641	152497641	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:152497641G>T	ENST00000256001.8	+	3	260	c.126G>T	c.(124-126)aaG>aaT	p.K42N	ACTR3B_ENST00000537264.1_Intron|ACTR3B_ENST00000377776.3_Missense_Mutation_p.K42N|ACTR3B_ENST00000397282.2_5'UTR	NM_020445.5	NP_065178.1	Q9P1U1	ARP3B_HUMAN	ARP3 actin-related protein 3 homolog B (yeast)	42					regulation of actin filament polymerization	cell projection|cytoplasm|cytoskeleton	actin binding|ATP binding			breast(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	13		all_hematologic(28;0.0592)|Prostate(32;0.191)	OV - Ovarian serous cystadenocarcinoma(82;0.0287)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0434)		AGTCAGCAAAGGTAGTTGACC	0.378000													12	65					1.5842e-08	1.59537e-08	1	1	0
PLCG2	5336	broad.mit.edu	37	16	81965259	81965259	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:81965259G>A	ENST00000359376.3	+	25	2953	c.2739_splice	c.e25+1	p.K913_splice		NM_002661.3	NP_002652.2	P16885	PLCG2_HUMAN	phospholipase C, gamma 2 (phosphatidylinositol-specific)	913					intracellular signal transduction|phospholipid catabolic process|platelet activation	plasma membrane	phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(18)|lung(21)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	58						TTGACACCAAGGTAGGCACCT	0.602000													32	60					0	0	1	0	0
SYNGAP1	8831	broad.mit.edu	37	6	33391261	33391261	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:33391261G>A	ENST00000418600.2	+	2	176	c.75G>A	c.(73-75)cgG>cgA	p.R25R	SYNGAP1_ENST00000496374.1_3'UTR|SYNGAP1_ENST00000293748.5_Silent_p.R25R	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	25					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						CAGATGTACGGGGACCCTCTA	0.522000													61	112					0	0	1	0	0
LAMP5	24141	broad.mit.edu	37	20	9496162	9496162	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:9496162C>T	ENST00000246070.2	+	2	619	c.127C>T	c.(127-129)Cct>Tct	p.P43S	LAMP5_ENST00000427562.2_Missense_Mutation_p.P43S	NM_012261.3	NP_036393.1	Q9UJQ1	CT103_HUMAN	lysosomal-associated membrane protein family, member 5	43						integral to membrane											TTCCACTAACCCTGAAAAAGA	0.438000													22	50					0	0	1	0	0
SLC35G5	83650	broad.mit.edu	37	8	11188832	11188832	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:11188832C>T	ENST00000382435.4	+	1	436	c.217C>T	c.(217-219)Ctc>Ttc	p.L73F		NM_054028.1	NP_473369.1	Q96KT7	AMCL2_HUMAN	solute carrier family 35, member G5	73	DUF6 1.					integral to membrane											GCTGGAGCTGCTCATCTGTCG	0.637000													82	145					0	0	1	0	0
PZP	5858	broad.mit.edu	37	12	9309930	9309930	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:9309930G>A	ENST00000261336.2	-	28	3419	c.3391C>T	c.(3391-3393)Ctg>Ttg	p.L1131L	PZP_ENST00000381997.2_Silent_p.L917L	NM_002864.2	NP_002855.2			pregnancy-zone protein											breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(21)|lung(46)|ovary(3)|prostate(2)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)	102						AGGCAGAACAGGGCATTGCGA	0.507000													21	31					0	0	1	0	0
WFDC13	164237	broad.mit.edu	37	20	44333185	44333185	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:44333185C>T	ENST00000305479.2	+	2	299	c.191C>T	c.(190-192)tCc>tTc	p.S64F	WFDC10B_ENST00000330523.5_5'UTR|WFDC10B_ENST00000335769.2_Silent_p.R30R	NM_172005.1	NP_742002.1	Q8IUB5	WFD13_HUMAN	WAP four-disulfide core domain 13	64						extracellular region	peptidase inhibitor activity			skin(1)|upper_aerodigestive_tract(1)	2		Myeloproliferative disorder(115;0.0122)				TGCTGTTCCTCCTTCTGTGGG	0.463000													25	83					0	0	1	0	0
SLC5A8	160728	broad.mit.edu	37	12	101577952	101577952	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:101577952G>A	ENST00000536262.2	-	8	1570	c.1012C>T	c.(1012-1014)Cct>Tct	p.P338S		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	338					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						AAAAGTCCAGGAAGTCCTGGA	0.348000													20	9					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29598914	29598914	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:29598914G>A	ENST00000431530.3	+	1	167	c.109G>A	c.(109-111)Gaa>Aaa	p.E37K		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	27						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						AAATAATAATGAAAGCATCTT	0.458000													17	53					0	0	1	0	0
TOX2	84969	broad.mit.edu	37	20	42694456	42694456	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:42694456C>T	ENST00000358131.5	+	6	1219	c.1011C>T	c.(1009-1011)ttC>ttT	p.F337F	TOX2_ENST00000372999.1_Silent_p.F313F|TOX2_ENST00000341197.3_Silent_p.F355F|TOX2_ENST00000435864.2_Silent_p.F233F|TOX2_ENST00000423191.1_Silent_p.F313F	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	337					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			TGGCCTCCTTCCTGACGCCGT	0.657000													70	176					0	0	1	0	0
PAM	5066	broad.mit.edu	37	5	102285616	102285616	+	Silent	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:102285616A>G	ENST00000438793.3	+	10	1205	c.735A>G	c.(733-735)gtA>gtG	p.V245V	PAM_ENST00000348126.2_Silent_p.V245V|PAM_ENST00000304400.7_Silent_p.V245V|PAM_ENST00000379787.4_5'UTR|PAM_ENST00000274392.9_Silent_p.V148V|PAM_ENST00000455264.2_Silent_p.V245V|PAM_ENST00000346918.2_Silent_p.V245V	NM_000919.3|NM_001177306.1|NM_138766.2	NP_000910.2|NP_001170777.1|NP_620121.1	P19021	AMD_HUMAN	peptidylglycine alpha-amidating monooxygenase	245	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding			endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	25		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	GTAAGGTAGTAAGTGGATACA	0.333000													12	16					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141459861	141459861	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:141459861C>T	ENST00000389484.3	-	39	7122	c.6150_splice	c.e39-1	p.E2051_splice		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	2051					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AATTTATTTTCCTAAATATCG	0.353000										TSP Lung(27;0.18)			16	79					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73046489	73046489	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:73046489G>A	ENST00000604411.1	+	0	34450				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						TCTCATCTTGGGATTTCCCCA	0.443000													77	21					0	0	1	0	0
DDX52	11056	broad.mit.edu	37	17	35978400	35978400	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:35978400G>A	ENST00000349699.2	-	14	1722	c.1679C>T	c.(1678-1680)cCa>cTa	p.P560L	DDX52_ENST00000394367.3_Missense_Mutation_p.P452L	NM_007010.3	NP_008941.2	Q9Y2R4	DDX52_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 52	560	Lys-rich.					nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			biliary_tract(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(5)|ovary(1)|skin(3)	17		Breast(25;0.00637)|Ovarian(249;0.15)				CCTTTCCAATGGTTTCTTAAT	0.303000													7	17					0	0	1	0	0
NR2F2	7026	broad.mit.edu	37	15	96877562	96877562	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:96877562C>T	ENST00000394166.3	+	2	2089	c.700C>T	c.(700-702)Ccc>Tcc	p.P234S	NR2F2_ENST00000453270.2_Missense_Mutation_p.P81S|NR2F2_ENST00000421109.2_Missense_Mutation_p.P101S|NR2F2_ENST00000394171.2_Missense_Mutation_p.P81S	NM_021005.3	NP_066285.1	P24468	COT2_HUMAN	nuclear receptor subfamily 2, group F, member 2	234	Interaction with ZFPM2 (By similarity).|Ligand-binding (By similarity).				lipid metabolic process|negative regulation of cyclin-dependent protein kinase activity|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment	nucleus	ligand-regulated transcription factor activity|protein homodimerization activity|retinoic acid binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(2)|lung(3)|ovary(2)|urinary_tract(1)	17	Lung NSC(78;0.0186)|Melanoma(26;0.0195)|all_lung(78;0.0297)		OV - Ovarian serous cystadenocarcinoma(32;0.0856)			CCCCTTCTTCCCCGACCTGCA	0.617000													52	74					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51870756	51870756	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:51870756G>A	ENST00000371497.5	+	2	1646	c.759G>A	c.(757-759)acG>acA	p.T253T	TSHZ2_ENST00000603338.2_Silent_p.T250T|TSHZ2_ENST00000329613.6_Silent_p.T250T	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	253					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			TCAGACCCACGAGCTATTCAA	0.493000													9	41					0	0	1	0	0
LOXL1	4016	broad.mit.edu	37	15	74219703	74219703	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:74219703C>T	ENST00000261921.7	+	1	905	c.579C>T	c.(577-579)ccC>ccT	p.P193P	LOXL1-AS1_ENST00000565756.1_RNA|LOXL1-AS1_ENST00000565416.1_RNA|LOXL1-AS1_ENST00000562965.1_RNA|LOXL1-AS1_ENST00000564963.1_RNA|LOXL1-AS1_ENST00000564194.1_RNA|LOXL1-AS1_ENST00000567257.1_RNA|LOXL1-AS1_ENST00000566675.1_RNA|LOXL1-AS1_ENST00000562739.1_RNA|LOXL1-AS1_ENST00000568087.1_RNA	NM_005576.2	NP_005567.2	Q08397	LOXL1_HUMAN	lysyl oxidase-like 1	193					protein deamination	extracellular space	copper ion binding			NS(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10						ACTACGACCCCGCGTCGCGGA	0.726000													30	34					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40384076	40384076	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:40384076G>A	ENST00000221347.6	-	21	9541	c.9534C>T	c.(9532-9534)gcC>gcT	p.A3178A		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	3178	TIL 7.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCTCACATACGGCTGGCGTCG	0.647000													45	170					0	0	1	0	0
TECRL	253017	broad.mit.edu	37	4	65274988	65274988	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:65274988C>T	ENST00000381210.3	-	1	192	c.82G>A	c.(82-84)Gat>Aat	p.D28N	TECRL_ENST00000507440.1_Missense_Mutation_p.D28N	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	28					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						CTCATATCATCCTTCAGTATG	0.433000													19	60					0	0	1	0	0
FBLN7	129804	broad.mit.edu	37	2	112944801	112944801	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:112944801C>T	ENST00000331203.2	+	8	1309	c.1038C>T	c.(1036-1038)tcC>tcT	p.S346S	FBLN7_ENST00000409667.3_Silent_p.S212S|FBLN7_ENST00000409450.3_Silent_p.S300S|FBLN7_ENST00000409903.1_Intron	NM_001128165.1|NM_153214.2	NP_001121637.1|NP_694946.2	Q53RD9	FBLN7_HUMAN	fibulin 7	346					cell adhesion	proteinaceous extracellular matrix	calcium ion binding|heparin binding			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						CTCTGCCTTCCAACCTGAAGA	0.647000													62	80					0	0	1	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325184	150325184	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:150325184G>A	ENST00000328902.5	-	3	718	c.502C>T	c.(502-504)Ctg>Ttg	p.L168L	GIMAP6_ENST00000493969.1_3'UTR	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	168							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCGCCAGCCAGGTCTTCCTTC	0.607000													101	164					0	0	1	0	0
PCDHA8	56140	broad.mit.edu	37	5	140221648	140221648	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140221648G>A	ENST00000531613.1	+	1	742	c.742G>A	c.(742-744)Gaa>Aaa	p.E248K	PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA8_ENST00000378123.3_Missense_Mutation_p.E248K|PCDHA4_ENST00000530339.1_Intron	NM_018911.2	NP_061734.1														NS(2)|breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(31)|ovary(2)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(6)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTCTGAATACGAAGTAAGAAT	0.453000													18	31					0	0	1	0	0
HTR4	3360	broad.mit.edu	37	5	147928281	147928281	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:147928281G>A	ENST00000360693.3	-	4	441	c.303C>T	c.(301-303)gtC>gtT	p.V101V	HTR4_ENST00000314512.6_Silent_p.V101V|HTR4_ENST00000354217.2_Silent_p.V101V|HTR4_ENST00000520514.1_Silent_p.V101V|HTR4_ENST00000517929.1_Silent_p.V101V|HTR4_ENST00000521530.1_Silent_p.V101V|HTR4_ENST00000362016.2_Silent_p.V101V|HTR4_ENST00000377888.3_Silent_p.V101V|HTR4_ENST00000521735.1_Silent_p.V101V	NM_001040173.2	NP_001035263.1	Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	101					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	TTGTGAGCAGGACGTCCAGAG	0.498000													9	8					0	0	1	0	0
BAALC	79870	broad.mit.edu	37	8	104225165	104225165	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:104225165T>G	ENST00000309982.5	+	2	367	c.179T>G	c.(178-180)cTg>cGg	p.L60R	RP11-318M2.2_ENST00000499522.2_RNA|RP11-318M2.2_ENST00000523614.2_RNA|BAALC_ENST00000438105.2_Intron|BAALC_ENST00000297574.6_Missense_Mutation_p.L95R	NM_024812.2	NP_079088.1	Q8WXS3	BAALC_HUMAN	brain and acute leukemia, cytoplasmic	95						centrosome|membrane|nucleus				kidney(1)|large_intestine(3)|lung(3)	7			OV - Ovarian serous cystadenocarcinoma(57;3.49e-05)|STAD - Stomach adenocarcinoma(118;0.133)			GAAGATGGACTGCCCTCCAAT	0.547000													34	74					0	0	1	0	0
PKP4	8502	broad.mit.edu	37	2	159488277	159488277	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:159488277C>T	ENST00000389757.3	+	8	1291	c.1166C>T	c.(1165-1167)tCc>tTc	p.S389F	PKP4_ENST00000389759.3_Missense_Mutation_p.S389F	NM_001005476.1	NP_001005476.1	Q99569	PKP4_HUMAN	plakophilin 4	389					cell adhesion	desmosome	protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(21)|ovary(6)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	61						TTACGGAGTTCCTATGCTAGT	0.438000										HNSCC(62;0.18)			53	72					0	0	1	0	0
C9	735	broad.mit.edu	37	5	39316104	39316104	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:39316104C>T	ENST00000263408.4	-	6	738	c.643G>A	c.(643-645)Gaa>Aaa	p.E215K	C9_ENST00000509186.1_5'UTR	NM_001737.3	NP_001728.1	P02748	CO9_HUMAN	complement component 9	215	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex		p.E215*(1)		central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	32	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			TCGTAATGTTCGGTTCTGAAA	0.313000													10	22					0	0	1	0	0
ESRRB	2103	broad.mit.edu	37	14	76964646	76964646	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:76964646C>T	ENST00000380887.2	+	7	1219	c.1147C>T	c.(1147-1149)Cat>Tat	p.H383Y	ESRRB_ENST00000509242.1_Missense_Mutation_p.H383Y|ESRRB_ENST00000556177.1_Missense_Mutation_p.H383Y|ESRRB_ENST00000261532.7_Missense_Mutation_p.H383Y|RP11-187O7.3_ENST00000554926.1_lincRNA			A2VDJ2	A2VDJ2_HUMAN	estrogen-related receptor beta	383						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			endometrium(2)|large_intestine(4)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(234;0.0213)		GAGCCAGCGCCATGAGGAGCC	0.617000													41	8					0	0	1	0	0
OLFML2A	169611	broad.mit.edu	37	9	127572460	127572460	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:127572460G>A	ENST00000373580.3	+	8	1728	c.1728G>A	c.(1726-1728)ggG>ggA	p.G576G	OLFML2A_ENST00000288815.5_Silent_p.G362G	NM_182487.2	NP_872293.2	Q68BL7	OLM2A_HUMAN	olfactomedin-like 2A	576	Olfactomedin-like.									endometrium(5)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	25						ACTCCTACGGGAACTGCTTCC	0.652000													21	31					0	0	1	0	0
KLHL38	340359	broad.mit.edu	37	8	124664268	124664268	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:124664268C>T	ENST00000325995.7	-	1	922	c.899G>A	c.(898-900)aGg>aAg	p.R300K	CTD-2552K11.2_ENST00000524355.1_RNA	NM_001081675.2	NP_001075144.2	Q2WGJ6	KLH38_HUMAN	kelch-like family member 38	300										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(16)|pancreas(1)|prostate(3)|stomach(1)	38						TAGGACGTCCCTGGTGGTCTG	0.567000													23	74					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	93956611	93956611	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:93956611C>T	ENST00000369303.4	-	15	2809	c.2625G>A	c.(2623-2625)aaG>aaA	p.K875K		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	875	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		CAGCACGCTCCTTTTGCCAAC	0.423000													23	37					0	0	1	0	0
PCID2	55795	broad.mit.edu	37	13	113833280	113833280	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:113833280C>T	ENST00000375457.2	-	13	1700	c.1104_splice	c.e13+1	p.M368_splice	PCID2_ENST00000375479.2_Splice_Site_p.M370_splice|PCID2_ENST00000493650.1_5'UTR|PCID2_ENST00000246505.5_Splice_Site_p.M424_splice|PCID2_ENST00000351317.3_Splice_Site_p.M347_splice|PCID2_ENST00000375459.1_Splice_Site_p.M368_splice|PCID2_ENST00000337344.4_Splice_Site_p.M370_splice|PCID2_ENST00000375477.1_Splice_Site_p.M370_splice	NM_001258213.1	NP_001245142.1	Q5JVF3	PCID2_HUMAN	PCI domain containing 2	370	PCI.				negative regulation of apoptosis|negative regulation of cysteine-type endopeptidase activity|positive regulation of mitotic cell cycle spindle assembly checkpoint|positive regulation of transcription, DNA-dependent|regulation of mRNA stability|spleen development		protein binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)	20	Lung NSC(43;0.0161)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.216)|all_epithelial(44;0.234)	all cancers(43;0.104)			ACTCACACACCATGTATATCA	0.433000													25	33					0	0	1	0	0
OR52J3	119679	broad.mit.edu	37	11	5068091	5068091	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:5068091G>A	ENST00000380370.1	+	1	336	c.336G>A	c.(334-336)atG>atA	p.M112I		NM_001001916.2	NP_001001916.2	Q8NH60	O52J3_HUMAN	olfactory receptor, family 52, subfamily J, member 3	112					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(6)|large_intestine(6)|lung(19)|ovary(1)|skin(2)	36		Medulloblastoma(188;0.00131)|all_neural(188;0.0189)|Breast(177;0.0204)		Epithelial(150;9.29e-10)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCACTGGCATGGAGGCTGAGG	0.512000													18	20					0	0	1	0	0
TGFBR2	7048	broad.mit.edu	37	3	30713877	30713877	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:30713877C>T	ENST00000295754.5	+	4	1584	c.1202C>T	c.(1201-1203)tCc>tTc	p.S401F	TGFBR2_ENST00000359013.4_Missense_Mutation_p.S426F	NM_003242.5	NP_003233.4	P37173	TGFR2_HUMAN	transforming growth factor, beta receptor II (70/80kDa)	401	Protein kinase.				activation of protein kinase activity|brain development|embryonic cranial skeleton morphogenesis|embryonic hemopoiesis|heart development|myeloid dendritic cell differentiation|palate development|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of B cell tolerance induction|positive regulation of mesenchymal cell proliferation|positive regulation of NK T cell differentiation|positive regulation of reactive oxygen species metabolic process|positive regulation of T cell tolerance induction|positive regulation of tolerance induction to self antigen|response to cholesterol|response to drug|transforming growth factor beta receptor signaling pathway|vasculogenesis	caveola|external side of plasma membrane	ATP binding|glycosaminoglycan binding|metal ion binding|protein binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type II|type I transforming growth factor beta receptor binding|type III transforming growth factor beta receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(15)|lung(10)|ovary(3)|pancreas(12)|skin(1)|stomach(5)|upper_aerodigestive_tract(2)	53						TTTGGGCTTTCCCTGCGTCTG	0.552000													106	153					0	0	1	0	0
CAMKMT	79823	broad.mit.edu	37	2	44617386	44617386	+	Silent	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:44617386T>C	ENST00000378494.3	+	3	362	c.318T>C	c.(316-318)aaT>aaC	p.N106N	CAMKMT_ENST00000402247.1_Silent_p.N106N|CAMKMT_ENST00000403853.3_Silent_p.N106N|CAMKMT_ENST00000477623.1_3'UTR|CAMKMT_ENST00000407131.1_Silent_p.N106N	NM_024766.3	NP_079042.1	Q7Z624	CMKMT_HUMAN	calmodulin-lysine N-methyltransferase	106						cytoplasm	calmodulin-lysine N-methyltransferase activity			breast(2)|large_intestine(3)|lung(5)	10						CTAGGCATAATAGTGGATCCT	0.303000													12	35					0	0	1	0	0
ZIM2	23619	broad.mit.edu	37	19	57286319	57286319	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:57286319G>A	ENST00000391708.3	-	12	1863	c.1321C>T	c.(1321-1323)Cct>Tct	p.P441S	AC006115.3_ENST00000597946.1_RNA|AC006115.3_ENST00000595954.1_RNA|AC006115.3_ENST00000594400.1_RNA|ZIM2_ENST00000601070.1_Missense_Mutation_p.P441S|ZIM2_ENST00000599935.1_Missense_Mutation_p.P441S|ZIM2_ENST00000593711.1_Missense_Mutation_p.P441S|ZIM2_ENST00000221722.5_Missense_Mutation_p.P441S	NM_001146326.1|NM_001146327.1	NP_001139798.1|NP_001139799.1			zinc finger, imprinted 2											NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(20)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0314)		AACCCAGGAGGAAGGACTCTT	0.478000													9	31					0	0	1	0	0
TET2	54790	broad.mit.edu	37	4	106155816	106155816	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:106155816C>T	ENST00000513237.1	+	3	1577	c.780C>T	c.(778-780)tcC>tcT	p.S260S	TET2_ENST00000540549.1_Silent_p.S239S|TET2_ENST00000413648.2_Silent_p.S239S|TET2_ENST00000545826.1_Silent_p.S239S|TET2_ENST00000380013.4_Silent_p.S239S|TET2_ENST00000394764.1_Silent_p.S239S|TET2_ENST00000305737.2_Silent_p.S239S			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	239					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		ATTGTGTTTCCATTGCGGTGC	0.448000			"""Mis N, F"""		MDS								24	12					0	0	1	0	0
PADI2	11240	broad.mit.edu	37	1	17413097	17413097	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:17413097G>A	ENST00000444885.2	-	5	590	c.509C>T	c.(508-510)tCg>tTg	p.S170L	PADI2_ENST00000375481.1_Silent_p.F251F|PADI2_ENST00000375486.4_Silent_p.F251F			Q9Y2J8	PADI2_HUMAN	peptidyl arginine deiminase, type II	0					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm	calcium ion binding|protein-arginine deiminase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(12)|ovary(4)|pancreas(1)|skin(5)|urinary_tract(3)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|Lung NSC(340;0.000422)|Renal(390;0.000518)|all_lung(284;0.000546)|Ovarian(437;0.00671)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00583)|BRCA - Breast invasive adenocarcinoma(304;1.49e-05)|COAD - Colon adenocarcinoma(227;1.54e-05)|Kidney(64;0.000258)|KIRC - Kidney renal clear cell carcinoma(64;0.00348)|STAD - Stomach adenocarcinoma(196;0.0072)|READ - Rectum adenocarcinoma(331;0.0698)|Lung(427;0.201)	L-Citrulline(DB00155)	GGCCTTCCACGAAGAACAGCA	0.622000													22	120					0	0	1	0	0
DNMT3B	1789	broad.mit.edu	37	20	31374395	31374395	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:31374395C>T	ENST00000328111.2	+	5	715	c.394C>T	c.(394-396)Cat>Tat	p.H132Y	DNMT3B_ENST00000348286.2_Missense_Mutation_p.H132Y|DNMT3B_ENST00000443239.3_Intron|DNMT3B_ENST00000456297.2_Intron|DNMT3B_ENST00000375623.4_Intron|DNMT3B_ENST00000344505.4_Missense_Mutation_p.H132Y|DNMT3B_ENST00000353855.2_Missense_Mutation_p.H132Y|DNMT3B_ENST00000201963.3_Missense_Mutation_p.H144Y	NM_006892.3	NP_008823.1	Q9UBC3	DNM3B_HUMAN	DNA (cytosine-5-)-methyltransferase 3 beta	132	Interaction with DNMT1 and DNMT3A.				negative regulation of histone H3-K9 methylation|positive regulation of gene expression|positive regulation of histone H3-K4 methylation		metal ion binding|protein binding|transcription corepressor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(16)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						GGGCCGCAACCATGTGGACGA	0.622000													18	116					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345778	33345778	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:33345778G>A	ENST00000374796.2	-	8	3343	c.773C>T	c.(772-774)cCc>cTc	p.P258L	NCOA6_ENST00000359003.2_Missense_Mutation_p.P258L			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	258	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						ctgcagctgGGGAAAATTAGC	0.522000													16	52					0	0	1	0	0
TRAK1	22906	broad.mit.edu	37	3	42264848	42264848	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:42264848C>T	ENST00000327628.5	+	16	2881	c.2481C>T	c.(2479-2481)gtC>gtT	p.V827V	TRAK1_ENST00000487159.1_3'UTR|TRAK1_ENST00000396175.1_Silent_p.V769V	NM_001042646.2	NP_001036111.1	Q9UPV9	TRAK1_HUMAN	trafficking protein, kinesin binding 1	827					endosome to lysosome transport|protein O-linked glycosylation|protein targeting|regulation of transcription from RNA polymerase II promoter	early endosome|mitochondrion|nucleus				central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	22						AAAAGAACGTCCGCAGCAGCG	0.577000													25	19					0	0	1	0	0
LRIT3	345193	broad.mit.edu	37	4	110790998	110790998	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:110790998C>T	ENST00000327908.3	+	4	1308	c.544C>T	c.(544-546)Cct>Tct	p.P182S	LRIT3_ENST00000379920.3_Missense_Mutation_p.P320S|LRIT3_ENST00000594814.1_Missense_Mutation_p.P365S|LRIT3_ENST00000409621.2_Missense_Mutation_p.P182S			Q3SXY7	LRIT3_HUMAN	leucine-rich repeat, immunoglobulin-like and transmembrane domains 3	320	LRRCT.					integral to membrane				cervix(1)|kidney(1)|large_intestine(3)|lung(8)|prostate(2)|skin(1)	16				OV - Ovarian serous cystadenocarcinoma(123;0.0011)		TGGAGATCATCCTGAGTGGGA	0.473000													30	130					0	0	1	0	0
KCNK1	3775	broad.mit.edu	37	1	233807022	233807022	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:233807022C>T	ENST00000366621.3	+	3	925	c.757C>T	c.(757-759)Ctg>Ttg	p.L253L	KCNK1_ENST00000472190.1_3'UTR|KCNK1_ENST00000366620.1_Silent_p.L137L	NM_002245.3	NP_002236.1	O00180	KCNK1_HUMAN	potassium channel, subfamily K, member 1	253						voltage-gated potassium channel complex	inward rectifier potassium channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(4)|skin(1)	11		all_cancers(173;0.00217)|all_epithelial(177;0.121)|Prostate(94;0.122)|Acute lymphoblastic leukemia(190;0.175)			Ibutilide(DB00308)|Quinidine(DB00908)	CACAGGTTACCTGCTACTTGG	0.423000													17	62					0	0	1	0	0
RYR2	6262	broad.mit.edu	37	1	237880516	237880516	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:237880516G>A	ENST00000366574.2	+	72	10659	c.10342G>A	c.(10342-10344)Gaa>Aaa	p.E3448K	RYR2_ENST00000542537.1_Missense_Mutation_p.E3432K|RYR2_ENST00000360064.6_Missense_Mutation_p.E3446K	NM_001035.2	NP_001026.2	Q92736	RYR2_HUMAN	ryanodine receptor 2 (cardiac)	3448					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding	p.E3446*(1)		NS(4)|breast(8)|central_nervous_system(11)|cervix(2)|endometrium(39)|haematopoietic_and_lymphoid_tissue(5)|kidney(17)|large_intestine(83)|liver(4)|lung(353)|ovary(18)|pancreas(5)|prostate(12)|skin(8)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(4)	586	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTCTGATCAGGAAAGGAAGAA	0.463000													18	7					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117232697	117232697	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:117232697G>A	ENST00000003084.6	+	14	2608	c.2476G>A	c.(2476-2478)Gaa>Aaa	p.E826K	CFTR_ENST00000454343.1_Missense_Mutation_p.E765K	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	826			E -> K (in thoracic sarcoidosis).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	AGAAATTAACGAAGAAGACTT	0.373000									Cystic Fibrosis				26	27					0	0	1	0	0
SCAPER	49855	broad.mit.edu	37	15	77020967	77020967	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:77020967C>T	ENST00000538941.2	-	17	2335	c.1396G>A	c.(1396-1398)Gcc>Acc	p.A466T	SCAPER_ENST00000563290.1_Missense_Mutation_p.A712T|SCAPER_ENST00000324767.7_Missense_Mutation_p.A712T	NM_001145923.1	NP_001139395.1	Q9BY12	SCAPE_HUMAN	S-phase cyclin A-associated protein in the ER	711	Glu-rich.					endoplasmic reticulum|nucleus	zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(16)|ovary(2)|prostate(2)|skin(1)|urinary_tract(2)	39						TCCTCACGGGCTTTTTCCTTT	0.448000													24	67					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105260930	105260930	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:105260930C>T	ENST00000507740.1	+	19	3156	c.2918_splice	c.e19-1	p.L974_splice	RIMS2_ENST00000339750.2_Splice_Site_p.L96_splice|RIMS2_ENST00000406091.3_Splice_Site_p.L1160_splice|RIMS2_ENST00000262231.10_Splice_Site_p.L999_splice|RIMS2_ENST00000436393.2_Splice_Site_p.L1178_splice	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1222					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGCTTTCAGTCTGATTTTCCC	0.463000										HNSCC(12;0.0054)			16	23					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50832017	50832017	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:50832017C>T	ENST00000442544.2	+	13	2597	c.1981C>T	c.(1981-1983)Cga>Tga	p.R661*	DCC_ENST00000581580.1_Nonsense_Mutation_p.R316*|DCC_ENST00000412726.1_Nonsense_Mutation_p.R509*	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	661	Fibronectin type-III 3.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane		p.R661*(1)		NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CTATAAAATTCGACACAGAAA	0.423000													20	31					0	0	1	0	0
SCN10A	6336	broad.mit.edu	37	3	38739372	38739372	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:38739372G>A	ENST00000449082.2	-	27	5338	c.5339C>T	c.(5338-5340)cCc>cTc	p.P1780L		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1780					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	ATTTCGATTGGGTTTTGGGAT	0.478000													6	61					0	0	1	0	0
IMPDH2	3615	broad.mit.edu	37	3	49066696	49066696	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:49066696G>A	ENST00000326739.4	-	1	127	c.88C>T	c.(88-90)Ctc>Ttc	p.L30F		NM_000884.2	NP_000875.2	P12268	IMDH2_HUMAN	IMP (inosine 5'-monophosphate) dehydrogenase 2	30					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|stomach(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	TTGTAGGTGAGGCCGTCTCCG	0.647000													4	12					0	0	1	0	0
RBMX	27316	broad.mit.edu	37	X	135960094	135960094	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:135960094G>A	ENST00000562646.1	-	4	522	c.368C>T	c.(367-369)cCc>cTc	p.P123L	RBMX_ENST00000570135.1_Intron|RBMX_ENST00000431446.3_Intron|RBMX_ENST00000320676.7_Missense_Mutation_p.P123L|RBMX_ENST00000565438.1_5'UTR			P38159	HNRPG_HUMAN	RNA binding motif protein, X-linked	123						catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(2)|lung(12)|ovary(2)|pancreas(1)|prostate(2)|urinary_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					TCCCCGTGAGGGAGGTCCCCT	0.542000													36	10					0	0	1	0	0
OR13D1	286365	broad.mit.edu	37	9	107457245	107457245	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:107457245G>A	ENST00000318763.5	+	1	586	c.543G>A	c.(541-543)tgG>tgA	p.W181*		NM_001004484.1	NP_001004484.1	Q8NGV5	O13D1_HUMAN	olfactory receptor, family 13, subfamily D, member 1	181					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(4)|lung(10)|ovary(1)|prostate(2)|skin(2)	19						CATGGTCCTGGATCATAGGCT	0.458000													42	20					0	0	1	0	0
EIF2AK1	27102	broad.mit.edu	37	7	6077153	6077153	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:6077153G>A	ENST00000199389.6	-	11	1380	c.1234C>T	c.(1234-1236)Cct>Tct	p.P412S	EIF2AK1_ENST00000536084.1_Missense_Mutation_p.P288S	NM_001134335.1|NM_014413.3	NP_001127807.1|NP_055228.2	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha kinase 1	412	Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	27		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		ATAACATAAGGACCTTGAAGT	0.299000													28	48					0	0	1	0	0
OR4K13	390433	broad.mit.edu	37	14	20502004	20502004	+	Splice_Site	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:20502004T>C	ENST00000315693.2	-	1	915	c.912_splice	c.e1+1	p.*305_splice		NM_001004714.1	NP_001004714.1	Q8NH42	OR4KD_HUMAN	olfactory receptor, family 4, subfamily K, member 13	0					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)	24	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2.9e-06)	GBM - Glioblastoma multiforme(265;0.0064)		GCTTTAAATTTATATGCAGAG	0.294000													8	4					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76482354	76482354	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:76482354G>A	ENST00000389840.5	-	45	7135	c.7011C>T	c.(7009-7011)ttC>ttT	p.F2337F	RP11-559N14.5_ENST00000585969.1_RNA|DNAH17_ENST00000585328.1_Silent_p.F2346F|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AGGTGAACACGAAGTACAGCT	0.627000													31	19					0	0	1	0	0
JMY	133746	broad.mit.edu	37	5	78610674	78610674	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:78610674G>A	ENST00000396137.4	+	9	3121	c.2659_splice	c.e9+1	p.V887_splice	JMY_ENST00000412001.1_Intron	NM_152405.4	NP_689618.4	Q8N9B5	JMY_HUMAN	junction mediating and regulatory protein, p53 cofactor	887					'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity			endometrium(4)|kidney(2)|large_intestine(2)|lung(6)|skin(1)|urinary_tract(1)	16		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		GAGGAGGAGAGGTACGTCAAC	0.443000													13	25					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113988066	113988066	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:113988066C>T	ENST00000297405.5	-	7	1586	c.1342_splice	c.e7+1	p.V448_splice	CSMD3_ENST00000343508.3_Splice_Site_p.V408_splice|CSMD3_ENST00000455883.2_Intron|CSMD3_ENST00000352409.3_Splice_Site_p.V448_splice	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	448						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CATCCAATACCTCTATGAGTA	0.383000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			44	84					0	0	1	0	0
CCNDBP1	23582	broad.mit.edu	37	15	43483811	43483811	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:43483811G>A	ENST00000300213.4	+	8	1040	c.798G>A	c.(796-798)ggG>ggA	p.G266G	EPB42_ENST00000563128.1_Intron|CCNDBP1_ENST00000356633.5_Silent_p.G105G	NM_012142.4	NP_036274.3	O95273	CCDB1_HUMAN	cyclin D-type binding-protein 1	266	Interaction with RPLP0.|Interaction with TCF3.				cell cycle	cytoplasm|nucleus	protein binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)	13		all_cancers(109;3.31e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;8.42e-07)		CAGAGAATGGGAAGAAGGATC	0.502000													10	32					0	0	1	0	0
GPR112	139378	broad.mit.edu	37	X	135429708	135429708	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:135429708G>A	ENST00000394143.1	+	6	4134	c.3843G>A	c.(3841-3843)aaG>aaA	p.K1281K	GPR112_ENST00000394141.1_Silent_p.K1076K|GPR112_ENST00000370652.1_Silent_p.K1281K|GPR112_ENST00000287534.4_Silent_p.K1218K|GPR112_ENST00000412101.1_Silent_p.K1076K	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	1281					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					CCCCATCAAAGAATTCTTTTA	0.433000													35	4					0	0	1	0	0
ARSJ	79642	broad.mit.edu	37	4	114824031	114824031	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:114824031C>T	ENST00000315366.7	-	2	2065	c.1199G>A	c.(1198-1200)gGc>gAc	p.G400D	ARSJ_ENST00000541197.1_Missense_Mutation_p.G400D	NM_024590.3	NP_078866.3	Q5FYB0	ARSJ_HUMAN	arylsulfatase family, member J	400						extracellular region	arylsulfatase activity|metal ion binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	21		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		GATATCATAGCCATCTAGTTG	0.458000													103	52					0	0	1	0	0
C3orf33	285315	broad.mit.edu	37	3	155481320	155481320	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:155481320G>A	ENST00000534941.1	-	6	1011	c.742C>T	c.(742-744)Cgt>Tgt	p.R248C	C3orf33_ENST00000340171.2_Missense_Mutation_p.R291C	NM_173657.1	NP_775928.1	Q96NB5	Q96NB5_HUMAN	chromosome 3 open reading frame 33	248							hydrolase activity, acting on ester bonds|nucleic acid binding	p.R242C(1)		breast(1)|kidney(1)|large_intestine(3)|lung(3)	8			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CCTTTTCTACGAAAGTTTATG	0.323000													11	13					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61946604	61946604	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:61946604C>T	ENST00000280772.1	-	17	2145	c.1954G>A	c.(1954-1956)Gaa>Aaa	p.E652K	ANK3_ENST00000373827.2_Missense_Mutation_p.E646K|ANK3_ENST00000503366.1_Missense_Mutation_p.E635K	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	652					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GCACCATATTCCAGCAGAGTT	0.537000													25	12					0	0	1	0	0
TGM4	7047	broad.mit.edu	37	3	44948573	44948573	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:44948573G>A	ENST00000296125.4	+	10	1276	c.1208G>A	c.(1207-1209)gGg>gAg	p.G403E		NM_003241.3	NP_003232.2	P49221	TGM4_HUMAN	transglutaminase 4	403					peptide cross-linking|protein polyamination		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(9)|lung(21)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)	38				BRCA - Breast invasive adenocarcinoma(193;0.00963)|KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0686)	L-Glutamine(DB00130)	ATGGTGAATGGGCAGGAGGAG	0.483000													42	84					0	0	1	0	0
ACSS2	55902	broad.mit.edu	37	20	33500980	33500980	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:33500980C>T	ENST00000360596.2	+	3	667	c.456C>T	c.(454-456)ctC>ctT	p.L152L	ACSS2_ENST00000336325.4_Silent_p.L102L|ACSS2_ENST00000476922.1_Intron|ACSS2_ENST00000253382.5_Silent_p.L152L	NM_018677.3	NP_061147.1	Q9NR19	ACSA_HUMAN	acyl-CoA synthetase short-chain family member 2	152					ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding			cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(9)	21					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GCAATGTTCTCCGAAAACAGG	0.532000													32	75					0	0	1	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140735534	140735534	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140735534C>T	ENST00000571252.1	+	1	767	c.767C>T	c.(766-768)cCt>cTt	p.P256L	PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018917.2	NP_061740.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGAACGTTCCTGTAGGCACT	0.478000													9	15					0	0	1	0	0
PTPRB	5787	broad.mit.edu	37	12	70980858	70980858	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:70980858C>T	ENST00000334414.6	-	9	2284	c.2240G>A	c.(2239-2241)cGa>cAa	p.R747Q	PTPRB_ENST00000538708.1_Missense_Mutation_p.R529Q|PTPRB_ENST00000451516.2_Missense_Mutation_p.R439Q|PTPRB_ENST00000261266.5_Missense_Mutation_p.R529Q|PTPRB_ENST00000551525.1_Missense_Mutation_p.R746Q|PTPRB_ENST00000550358.1_Missense_Mutation_p.R747Q|PTPRB_ENST00000550857.1_Missense_Mutation_p.R439Q|PTPRB_ENST00000538174.2_5'UTR	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	529	Fibronectin type-III 9.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			CATGTATTTTCGTCCAGGCAC	0.373000													17	35					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133542279	133542279	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:133542279G>A	ENST00000409261.1	-	14	2478	c.2105C>T	c.(2104-2106)cCt>cTt	p.P702L	NCKAP5_ENST00000317721.6_Missense_Mutation_p.P702L|NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	702							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						GGGTCCAGCAGGAGTTGAATT	0.448000													49	64					0	0	1	0	0
F2RL1	2150	broad.mit.edu	37	5	76129488	76129488	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:76129488G>A	ENST00000296677.4	+	2	1262	c.1056G>A	c.(1054-1056)agG>agA	p.R352R		NM_005242.4	NP_005233.3	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	352					blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|skin(1)|urinary_tract(1)	13		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		ATGATTTCAGGGATCATGCAA	0.473000													157	202					0	0	1	0	0
EML5	161436	broad.mit.edu	37	14	89202745	89202745	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:89202745G>A	ENST00000554922.1	-	7	1260	c.1012C>T	c.(1012-1014)Cct>Tct	p.P338S	EML5_ENST00000380664.5_Missense_Mutation_p.P338S|EML5_ENST00000352093.5_Missense_Mutation_p.P338S	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	338						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						ACAGCCAAAGGTTTAGTAGGA	0.368000													95	30					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14107244	14107244	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:14107244C>T	ENST00000235372.7	+	8	3810	c.2954C>T	c.(2953-2955)cCg>cTg	p.P985L	PRDM2_ENST00000343137.4_Missense_Mutation_p.P784L|PRDM2_ENST00000311066.5_Missense_Mutation_p.P985L|PRDM2_ENST00000376048.5_Intron|PRDM2_ENST00000503842.1_Intron|PRDM2_ENST00000413440.1_Missense_Mutation_p.P784L|PRDM2_ENST00000505823.1_Intron	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	985	Pro-rich.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		GTTGCCACTCCGCCCCCTCCC	0.612000													31	131					0	0	1	0	0
ANK2	287	broad.mit.edu	37	4	114275901	114275901	+	Nonsense_Mutation	SNP	C	C	T	rs35152218		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:114275901C>T	ENST00000357077.4	+	38	6180	c.6127C>T	c.(6127-6129)Cag>Tag	p.Q2043*	ANK2_ENST00000509550.1_Intron|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000264366.6_Nonsense_Mutation_p.Q2010*|ANK2_ENST00000506722.1_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	2010					axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GAGAGAAGCTCAGAAAACAGA	0.453000													61	43					0	0	1	0	0
SERPINI2	5276	broad.mit.edu	37	3	167189480	167189480	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:167189480G>A	ENST00000476257.1	-	3	441	c.143C>T	c.(142-144)tCa>tTa	p.S48L	SERPINI2_ENST00000264677.4_Missense_Mutation_p.S48L|SERPINI2_ENST00000461846.1_Missense_Mutation_p.S48L|SERPINI2_ENST00000471111.1_Missense_Mutation_p.S48L|SERPINI2_ENST00000465031.1_5'UTR			O75830	SPI2_HUMAN	serpin peptidase inhibitor, clade I (pancpin), member 2	48					cellular component movement|regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(20)|prostate(1)|skin(5)|urinary_tract(1)	41						TCCAAGGGGTGAAAATATAAT	0.393000													36	45					0	0	1	0	0
EXOC3	11336	broad.mit.edu	37	5	453869	453869	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:453869C>T	ENST00000512944.1	+	4	938	c.749C>T	c.(748-750)aCc>aTc	p.T250I	EXOC3_ENST00000315013.5_Missense_Mutation_p.T250I	NM_007277.4	NP_009208.2	O60645	EXOC3_HUMAN	exocyst complex component 3	261					exocytosis|protein transport					breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(13)|ovary(1)|urinary_tract(1)	23		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			AAAATGTTCACCATCTTGGAG	0.488000													56	36					0	0	1	0	0
TROAP	10024	broad.mit.edu	37	12	49724537	49724537	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:49724537C>T	ENST00000551245.1	+	13	2020	c.1909C>T	c.(1909-1911)Cct>Tct	p.P637S	TROAP_ENST00000257909.3_Missense_Mutation_p.P637S|TROAP_ENST00000547923.1_Missense_Mutation_p.P316S			Q12815	TROAP_HUMAN	trophinin associated protein	637	4 X 33 AA approximate tandem repeats.|Cys-rich.				cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						AGGGCCCTGCCCTAGGGTAGA	0.647000													14	66					0	0	1	0	0
CACNA1H	8912	broad.mit.edu	37	16	1268386	1268386	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:1268386G>A	ENST00000348261.5	+	33	5870	c.5622G>A	c.(5620-5622)gcG>gcA	p.A1874A	CACNA1H_ENST00000358590.4_Silent_p.A1868A|CACNA1H_ENST00000565831.1_Silent_p.A1868A	NM_021098.2	NP_066921.2	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type, alpha 1H subunit	1874					aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(4)|endometrium(5)|kidney(2)|lung(23)	34		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	GGGAGGATGCGGAGCTGGACG	0.682000													4	6					0	0	1	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20489465	20489465	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:20489465C>T	ENST00000555186.1	+	0	453					NR_038836.1																						CAACTTCATTCCTAAAGTCTG	0.423000													4	44					0	0	1	0	0
RP11-478B9.1	0	broad.mit.edu	37	12	45457377	45457377	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:45457377G>A	ENST00000548424.1	+	0	448																											CTGTGACAGGGAACTAGATGA	0.463000													16	17					0	0	1	0	0
C12orf68	387856	broad.mit.edu	37	12	48578275	48578275	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:48578275G>A	ENST00000316554.3	+	1	910	c.370G>A	c.(370-372)Ggg>Agg	p.G124R		NM_001013635.3	NP_001013657.3	Q52MB2	CL068_HUMAN	chromosome 12 open reading frame 68	124						cytoplasm				central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)	4						TCCTTCGCCTGGGATCGGGGA	0.672000													10	7					0	0	1	0	0
CFHR5	81494	broad.mit.edu	37	1	196973818	196973818	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:196973818C>T	ENST00000367414.5	+	9	1486	c.1430C>T	c.(1429-1431)cCa>cTa	p.P477L	CFHR5_ENST00000256785.4_Missense_Mutation_p.P453L	NM_030787.3	NP_110414.1	Q9BXR6	FHR5_HUMAN	complement factor H-related 5	453	Sushi 8.				complement activation, alternative pathway	extracellular region				NS(2)|breast(2)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(23)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)	49						GGGCCCCCTCCATCTATTAAC	0.398000													23	116					0	0	1	0	0
ISLR	3671	broad.mit.edu	37	15	74467458	74467458	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:74467458C>T	ENST00000249842.3	+	2	616	c.259C>T	c.(259-261)Cgc>Tgc	p.R87C	ISLR_ENST00000395118.1_Missense_Mutation_p.R87C|RP11-665J16.1_ENST00000561647.1_RNA	NM_005545.3	NP_005536.1	O14498	ISLR_HUMAN	immunoglobulin superfamily containing leucine-rich repeat	87					cell adhesion	extracellular region				central_nervous_system(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	20						CAATGAGATCCGCACGGTGGC	0.632000													28	23					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155311831	155311831	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:155311831G>A	ENST00000460012.1	-	4	636	c.279C>T	c.(277-279)tcC>tcT	p.S93S	PLCH1_ENST00000447496.2_Silent_p.S111S|PLCH1_ENST00000414191.1_Silent_p.S93S|PLCH1_ENST00000340059.7_Silent_p.S111S|PLCH1_ENST00000334686.6_Silent_p.S93S|PLCH1_ENST00000494598.1_Silent_p.S111S			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	111	PH.				lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CCTCGGGGTTGGAGGTGATGA	0.567000													17	21					0	0	1	0	0
CELF4	56853	broad.mit.edu	37	18	34850768	34850768	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:34850768C>T	ENST00000420428.2	-	8	1457	c.1062G>A	c.(1060-1062)gcG>gcA	p.A354A	CELF4_ENST00000591282.1_Silent_p.A354A|CELF4_ENST00000591287.1_Silent_p.A353A|CELF4_ENST00000334919.5_Silent_p.A344A|CELF4_ENST00000601019.1_Silent_p.A352A|CELF4_ENST00000412753.1_Silent_p.A353A|CELF4_ENST00000361795.5_Silent_p.A352A|CELF4_ENST00000603232.1_Silent_p.A353A|CELF4_ENST00000588597.1_Silent_p.A343A	NM_020180.3	NP_064565.1	Q9BZC1	CELF4_HUMAN	CUGBP, Elav-like family member 4	354					embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding	p.A354A(1)		breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(18)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	44						ACACAGCTTCCGCAGCAGGTT	0.587000													23	58					0	0	1	0	0
C7orf62	219557	broad.mit.edu	37	7	88423533	88423533	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:88423533C>T	ENST00000297203.2	-	2	909	c.724G>A	c.(724-726)Gat>Aat	p.D242N	ZNF804B_ENST00000333190.4_Intron	NM_152706.3	NP_689919.1	Q8TBZ9	CG062_HUMAN	chromosome 7 open reading frame 62	242										NS(1)|breast(1)|endometrium(3)|large_intestine(8)|lung(13)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	30						ACCTCAGAATCCAGAGTGATG	0.403000													7	19					0	0	1	0	0
KHDC1	80759	broad.mit.edu	37	6	73951871	73951871	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:73951871G>A	ENST00000423730.3	-	3	637	c.202C>T	c.(202-204)Cgt>Tgt	p.R68C	KHDC1_ENST00000257765.5_Missense_Mutation_p.R68C|KHDC1_ENST00000370384.3_Missense_Mutation_p.R141C																							ACAGTCACACGAGTCTGGCCT	0.542000													24	15					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130409144	130409144	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:130409144C>T	ENST00000370904.1	-	23	4184	c.3274G>A	c.(3274-3276)Gag>Aag	p.E1092K	IGSF1_ENST00000361420.3_Missense_Mutation_p.E1101K|IGSF1_ENST00000370910.1_Missense_Mutation_p.E1092K|IGSF1_ENST00000370903.3_Missense_Mutation_p.E1106K			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	1101	Ig-like C2-type 11.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						TGAGCCCCCTCCTTCAACAGG	0.547000													132	28					0	0	1	0	0
C17orf104	284071	broad.mit.edu	37	17	42745073	42745073	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:42745073G>A	ENST00000409122.2	+	5	1936	c.1794G>A	c.(1792-1794)ggG>ggA	p.G598G	C17orf104_ENST00000409464.1_Silent_p.G432G|C17orf104_ENST00000359945.3_Silent_p.G598G	NM_001145080.2	NP_001138552.2	A2RUB1	CQ104_HUMAN	chromosome 17 open reading frame 104	598										autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|pancreas(1)|skin(1)	24						AGAAGTATGGGATAATTGAAA	0.353000													7	12					0	0	1	0	0
PLEC	5339	broad.mit.edu	37	8	144991293	144991293	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:144991293G>A	ENST00000322810.4	-	32	13276	c.13107C>T	c.(13105-13107)ttC>ttT	p.F4369F	PLEC_ENST00000354958.2_Silent_p.F4210F|PLEC_ENST00000356346.3_Silent_p.F4218F|PLEC_ENST00000527096.1_Silent_p.F4255F|PLEC_ENST00000436759.2_Silent_p.F4259F|PLEC_ENST00000357649.2_Silent_p.F4236F|PLEC_ENST00000398774.2_Silent_p.F4200F|PLEC_ENST00000345136.3_Silent_p.F4232F|PLEC_ENST00000354589.3_Silent_p.F4232F	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	4369	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						GCATGTCGGCGAACTCGGTGA	0.667000													34	53					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56202404	56202404	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:56202404G>A	ENST00000361673.3	-	5	5228	c.5015C>T	c.(5014-5016)cCa>cTa	p.P1672L		NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1672							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CTTTTGACATGGATCCTGCAG	0.532000													29	60					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48807693	48807693	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:48807693G>A	ENST00000316623.5	-	12	1814	c.1359C>T	c.(1357-1359)tgC>tgT	p.C453C		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	453	EGF-like 6.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GGACCAACTGGCAGTAATCAG	0.463000													36	30					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1488578	1488578	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:1488578C>T	ENST00000345913.4	+	9	1640	c.1549C>T	c.(1549-1551)Ctg>Ttg	p.L517L	TPO_ENST00000337415.3_Silent_p.L517L|TPO_ENST00000349624.3_Silent_p.L344L|TPO_ENST00000329066.4_Silent_p.L517L|TPO_ENST00000382201.3_Silent_p.L517L|TPO_ENST00000346956.3_Silent_p.L517L|TPO_ENST00000497517.2_3'UTR|TPO_ENST00000382198.1_Silent_p.L344L	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	517					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	CCTGCCCGGGCTGTGGCTGCA	0.627000													12	45					0	0	1	0	0
ELF2	1998	broad.mit.edu	37	4	139994657	139994657	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:139994657G>A	ENST00000394235.2	-	5	805	c.303C>T	c.(301-303)gcC>gcT	p.A101A	ELF2_ENST00000379549.2_Silent_p.A41A|ELF2_ENST00000379550.1_Silent_p.A101A|ELF2_ENST00000358635.3_Silent_p.A41A|ELF2_ENST00000510408.1_Silent_p.A41A|ELF2_ENST00000265495.4_Silent_p.A101A	NM_001276458.1	NP_001263387.1	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription factor)	101					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(4)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	19	all_hematologic(180;0.162)					TATGAAGCAGGGCTTCAGCAG	0.383000													24	23					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9060431	9060431	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:9060431C>T	ENST00000397910.4	-	3	27218	c.27015G>A	c.(27013-27015)agG>agA	p.R9005R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9007	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGCTGGTCTCCCTTGGTGTGG	0.498000													38	62					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121743921	121743921	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:121743921C>T	ENST00000452319.1	+	13	2084	c.2024C>T	c.(2023-2025)cCc>cTc	p.P675L	GLI2_ENST00000314490.11_Missense_Mutation_p.P347L|GLI2_ENST00000435313.2_3'UTR|GLI2_ENST00000361492.4_Missense_Mutation_p.P675L			P10070	GLI2_HUMAN	GLI family zinc finger 2	675					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GGCAGTGCCCCCAACAATGAC	0.687000													26	40					0	0	1	0	0
PTPN22	26191	broad.mit.edu	37	1	114380238	114380238	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:114380238A>G	ENST00000359785.5	-	13	1919	c.1784T>C	c.(1783-1785)cTa>cCa	p.L595P	PTPN22_ENST00000528414.1_Missense_Mutation_p.L540P|PTPN22_ENST00000525799.1_Missense_Mutation_p.L468P|PTPN22_ENST00000460620.1_Intron|PTPN22_ENST00000420377.2_Missense_Mutation_p.L595P|PTPN22_ENST00000538253.1_Missense_Mutation_p.L351P	NM_001193431.1|NM_015967.5	NP_001180360.1|NP_057051.3	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	595					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			NS(1)|breast(1)|kidney(3)|large_intestine(4)|lung(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGGTTCAATAGTGAGGAAAT	0.333000													59	19					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179408342	179408342	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179408342C>T	ENST00000589042.1	-	347	96582	c.96358G>A	c.(96358-96360)Gat>Aat	p.D32120N	TTN_ENST00000342992.6_Missense_Mutation_p.D29552N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.D30479N|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.D23055N|TTN_ENST00000342175.6_Missense_Mutation_p.D23247N|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D23180N|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	30479	Fibronectin type-III 132.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCACAGAATCTCTTGATACT	0.393000													9	11					0	0	1	0	0
PHKA1	5255	broad.mit.edu	37	X	71825251	71825251	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:71825251C>T	ENST00000373545.3	-	24	2947		c.e24-1		PHKA1_ENST00000541944.1_Splice_Site|PHKA1_ENST00000373542.4_Splice_Site|PHKA1_ENST00000339490.3_Splice_Site|PHKA1_ENST00000373539.3_Splice_Site			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)						glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					CCATTATTTCCTGCACACAGA	0.373000													29	3					0	0	1	0	0
OR10AD1	121275	broad.mit.edu	37	12	48597048	48597048	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:48597048C>T	ENST00000310248.2	-	1	122	c.28G>A	c.(28-30)Gaa>Aaa	p.E10K		NM_001004134.1	NP_001004134.1	Q8NGE0	O10AD_HUMAN	olfactory receptor, family 10, subfamily AD, member 1	10					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(2)|lung(3)|ovary(1)|stomach(1)|urinary_tract(1)	9						AGGATAAATTCCGTCACTATG	0.517000													5	41					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158504519	158504519	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:158504519G>A	ENST00000355585.4	+	21	2999	c.2924G>A	c.(2923-2925)cGa>cAa	p.R975Q	SYNJ2_ENST00000367121.3_Missense_Mutation_p.R975Q|SYNJ2_ENST00000367112.1_Missense_Mutation_p.R60Q|SYNJ2_ENST00000367122.2_Missense_Mutation_p.R975Q	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	975							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		AAAGGTTTGCGAGAGGAGATC	0.502000													30	37					0	0	1	0	0
OTUD7B	56957	broad.mit.edu	37	1	149915902	149915902	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:149915902G>A	ENST00000369135.3	-	12	2680	c.2386C>T	c.(2386-2388)Ccc>Tcc	p.P796S		NM_020205.2	NP_064590.2	Q6GQQ9	OTU7B_HUMAN	OTU domain containing 7B	796					negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			TGAGTTGGGGGAAGGCCCCGG	0.542000													33	156					0	0	1	0	0
SLC17A2	10246	broad.mit.edu	37	6	25917006	25917006	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:25917006G>A	ENST00000377850.3	-	8	1361	c.837C>T	c.(835-837)ttC>ttT	p.F279F	SLC17A2_ENST00000360488.3_Silent_p.F279F|SLC17A2_ENST00000265425.3_Silent_p.F279F			O00624	NPT3_HUMAN	solute carrier family 17, member 2	279					phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			endometrium(3)|kidney(1)|large_intestine(9)|lung(12)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	31						AAAAACCCAGGAAAATGGCCC	0.448000													49	34					0	0	1	0	0
HCN1	348980	broad.mit.edu	37	5	45396699	45396699	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:45396699G>A	ENST00000303230.4	-	4	1182	c.1125C>T	c.(1123-1125)acC>acT	p.T375T		NM_021072.3	NP_066550.2	O60741	HCN1_HUMAN	hyperpolarization activated cyclic nucleotide-gated potassium channel 1	375						integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			NS(3)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(21)|liver(1)|lung(98)|ovary(1)|prostate(7)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(5)	156						TGCTCAGCATGGTAATCCAGA	0.522000													16	30					0	0	1	0	0
HNRNPM	4670	broad.mit.edu	37	19	8550960	8550960	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:8550960C>T	ENST00000348943.3	+	15	1763	c.1531C>T	c.(1531-1533)Cgc>Tgc	p.R511C	HNRNPM_ENST00000325495.4_Missense_Mutation_p.R550C	NM_031203.3	NP_112480.2	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	550	27 X 6 AA repeats of [GEVSTPAN]-[ILMV]- [DE]-[RH]-[MLVI]-[GAV].				alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding			endometrium(5)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)	25						CGTGATGGATCGCATGGCCAC	0.701000													60	82					0	0	1	0	0
ATRNL1	26033	broad.mit.edu	37	10	117228754	117228754	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:117228754C>T	ENST00000355044.3	+	24	3695	c.3569C>T	c.(3568-3570)tCc>tTc	p.S1190F	ATRNL1_ENST00000303745.7_Intron|ATRNL1_ENST00000423111.2_Missense_Mutation_p.S241F	NM_207303.2	NP_997186.1	Q5VV63	ATRN1_HUMAN	attractin-like 1	1190						integral to membrane	sugar binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(11)|liver(2)|lung(44)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		GATAGTTTTTCCTATGAAAAA	0.289000													8	14					0	0	1	0	0
CERKL	375298	broad.mit.edu	37	2	182413434	182413434	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:182413434G>A	ENST00000410087.3	-	7	1146	c.1046C>T	c.(1045-1047)gCt>gTt	p.A349V	CERKL_ENST00000409440.3_Missense_Mutation_p.A331V|CERKL_ENST00000374969.2_Missense_Mutation_p.A236V|CERKL_ENST00000374970.2_Missense_Mutation_p.A280V|CERKL_ENST00000339098.5_Missense_Mutation_p.A375V|CERKL_ENST00000479558.1_5'UTR	NM_001030311.2|NM_201548.4	NP_001025482.1|NP_963842.1	Q49MI3	CERKL_HUMAN	ceramide kinase-like	375					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|Golgi apparatus|nucleolus	diacylglycerol kinase activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(13)|ovary(3)|skin(3)	32			OV - Ovarian serous cystadenocarcinoma(117;0.088)			CTTAACAACAGCAAAATCTCT	0.383000													31	40					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56183135	56183135	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:56183135C>T	ENST00000288221.6	-	5	1430	c.1175G>A	c.(1174-1176)cGa>cAa	p.R392Q		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	392						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		CCTTATGTTTCGTTCCAATGA	0.333000													6	16					0	0	1	0	0
PTCHD3	374308	broad.mit.edu	37	10	27702223	27702223	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:27702223G>A	ENST00000438700.3	-	1	1074	c.957C>T	c.(955-957)gcC>gcT	p.A319A		NM_001034842.3	NP_001030014.2	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	319					spermatid development	integral to membrane	hedgehog receptor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	55						GCATGGCTTTGGCCCGCAGGA	0.582000													58	25					0	0	1	0	0
APOA4	337	broad.mit.edu	37	11	116692146	116692146	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:116692146C>T	ENST00000357780.3	-	3	742	c.628G>A	c.(628-630)Gtc>Atc	p.V210I		NM_000482.3	NP_000473.2			apolipoprotein A-IV											cervix(1)|endometrium(2)|lung(10)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Breast(348;0.0126)|Medulloblastoma(222;0.0425)|all_hematologic(158;0.0564)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|Epithelial(105;1.62e-05)|all cancers(92;0.000165)|OV - Ovarian serous cystadenocarcinoma(223;0.148)		TCAATCTTGACTTTGAATTCG	0.617000													81	124					0	0	1	0	0
EMR1	2015	broad.mit.edu	37	19	6913769	6913769	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:6913769G>A	ENST00000312053.4	+	11	1265	c.1228G>A	c.(1228-1230)Gaa>Aaa	p.E410K	EMR1_ENST00000381404.4_Missense_Mutation_p.E358K|EMR1_ENST00000250572.8_Missense_Mutation_p.E410K|EMR1_ENST00000381407.5_Missense_Mutation_p.E269K|EMR1_ENST00000450315.3_Missense_Mutation_p.E233K	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	410	Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					GGAGAGTGTGGAAAGCATGAC	0.483000													51	82					0	0	1	0	0
ACVRL1	94	broad.mit.edu	37	12	52309872	52309872	+	Missense_Mutation	SNP	C	C	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:52309872C>G	ENST00000550683.1	+	7	1244	c.1143C>G	c.(1141-1143)aaC>aaG	p.N381K	ACVRL1_ENST00000388922.4_Missense_Mutation_p.N367K|ACVRL1_ENST00000419526.2_Missense_Mutation_p.N193K	NM_001077401.1	NP_001070869.1	P37023	ACVL1_HUMAN	activin A receptor type II-like 1	367	Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	TCGGCAACAACCCGAGAGTGG	0.612000													17	57					0	0	1	0	0
ANKK1	255239	broad.mit.edu	37	11	113270852	113270852	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:113270852C>T	ENST00000303941.3	+	8	2255	c.2161C>T	c.(2161-2163)Cag>Tag	p.Q721*		NM_178510.1	NP_848605.1	Q8NFD2	ANKK1_HUMAN	ankyrin repeat and kinase domain containing 1	721							ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|stomach(1)	29		all_cancers(61;1.53e-11)|all_epithelial(67;3e-06)|Melanoma(852;4.04e-05)|all_hematologic(158;0.000315)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0461)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Prostate(24;0.194)		BRCA - Breast invasive adenocarcinoma(274;4.82e-06)|Epithelial(105;5.41e-05)|all cancers(92;0.000442)|OV - Ovarian serous cystadenocarcinoma(223;0.238)		GCTGGACGTCCAGGATGGAGT	0.652000													8	19					0	0	1	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20903668	20903668	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:20903668G>A	ENST00000381552.1	+	14	2226	c.1858G>A	c.(1858-1860)Gga>Aga	p.G620R	SLCO1C1_ENST00000266509.2_Missense_Mutation_p.G620R|SLCO1C1_ENST00000545102.1_Missense_Mutation_p.G502R|SLCO1C1_ENST00000540354.1_Missense_Mutation_p.G571R|SLCO1C1_ENST00000545604.1_Missense_Mutation_p.G620R			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	620					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					CCTCAAATGGGGATTTAAAAG	0.373000													18	18					0	0	1	0	0
FGFRL1	53834	broad.mit.edu	37	4	1018754	1018754	+	Silent	SNP	C	C	T	rs111246053		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:1018754C>T	ENST00000398484.2	+	8	1714	c.1134C>T	c.(1132-1134)ccC>ccT	p.P378P	FGFRL1_ENST00000504138.1_Silent_p.P378P|FGFRL1_ENST00000264748.6_Silent_p.P378P|FGFRL1_ENST00000510644.1_Silent_p.P378P			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	378				Missing (in Ref. 3; AAK15273).	regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			TGCCGTGGCCCGTGGTCATCG	0.682000													47	30					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25327975	25327975	+	RNA	SNP	T	T	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:25327975T>G	ENST00000546682.1	+	0	188				SNORD116-16_ENST00000384533.1_RNA|SNHG14_ENST00000549804.2_RNA	NR_003361.1																						GAGTGAAAACTCTATACCGTC	0.478000													78	84					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25463617	25463617	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:25463617C>T	ENST00000424208.1	+	0	2900				SNHG14_ENST00000453082.2_RNA	NR_003305.1																						CTTGCTTTTCCTGGGCCAGTG	0.577000													11	11					0	0	1	0	0
SPPL2C	162540	broad.mit.edu	37	17	43923502	43923502	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:43923502C>T	ENST00000329196.5	+	1	1247	c.1230C>T	c.(1228-1230)ggC>ggT	p.G410G	MAPT-AS1_ENST00000579244.1_RNA|MAPT-AS1_ENST00000579599.1_RNA	NM_175882.2	NP_787078.2	Q8IUH8	IMP5_HUMAN	signal peptide peptidase like 2C	410						integral to membrane	aspartic-type endopeptidase activity										TTGCCTTGGGCCCTGCAGAGT	0.587000													25	39					0	0	1	0	0
TSHZ1	10194	broad.mit.edu	37	18	72998696	72998696	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:72998696C>T	ENST00000322038.5	+	2	1783	c.1199C>T	c.(1198-1200)aCc>aTc	p.T400I	TSHZ1_ENST00000580243.1_Missense_Mutation_p.T445I	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	445						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CTGAAAGTGACCACCTCGGCT	0.607000													23	34					0	0	1	0	0
ALPK3	57538	broad.mit.edu	37	15	85400580	85400580	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:85400580C>T	ENST00000258888.5	+	6	3384	c.3217C>T	c.(3217-3219)Cct>Tct	p.P1073S		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	1073					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GCCTTCTCTTCCTGGAACTGG	0.642000													9	19					0	0	1	0	0
ACACB	32	broad.mit.edu	37	12	109696852	109696852	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:109696852C>T	ENST00000338432.7	+	47	6554	c.6435C>T	c.(6433-6435)aaC>aaT	p.N2145N	ACACB_ENST00000543201.1_Silent_p.N811N|ACACB_ENST00000377854.5_Silent_p.N2075N|ACACB_ENST00000377848.3_Silent_p.N2145N			O00763	ACACB_HUMAN	acetyl-CoA carboxylase beta	2145	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			NS(1)|breast(2)|endometrium(9)|kidney(5)|large_intestine(20)|lung(40)|ovary(6)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95					Biotin(DB00121)	AGGACTTCAACCGGGAGAAGT	0.572000													83	98					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4510789	4510789	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:4510789G>A	ENST00000301286.3	-	3	3140	c.3141C>T	c.(3139-3141)gcC>gcT	p.A1047A		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	1047						lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						CCCAGGAGGTGGCGGGGGTAC	0.647000													29	35					0	0	1	0	0
PNPLA1	285848	broad.mit.edu	37	6	36259166	36259166	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:36259166C>T	ENST00000394571.2	+	2	275	c.275C>T	c.(274-276)cCg>cTg	p.P92L	PNPLA1_ENST00000312917.5_5'UTR|PNPLA1_ENST00000388715.3_5'UTR	NM_001145717.1	NP_001139189.2	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	92	Patatin.				lipid catabolic process		hydrolase activity			breast(1)|kidney(1)|large_intestine(4)|lung(9)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)	22						CCCTTGTCCCCGTCCTGTAAG	0.577000													49	38					0	0	1	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62611165	62611165	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:62611165G>A	ENST00000281156.4	-	5	873	c.595C>T	c.(595-597)Ccc>Tcc	p.P199S		NM_152688.2	NP_689901.2	Q5VWX1	KHDR2_HUMAN	KH domain containing, RNA binding, signal transduction associated 2	199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(5)|liver(1)|lung(13)|ovary(3)|prostate(3)|skin(12)|upper_aerodigestive_tract(2)|urinary_tract(1)	49				BRCA - Breast invasive adenocarcinoma(397;0.149)		GGAGCTGTGGGAGCTATTCTG	0.408000													10	96					0	0	1	0	0
C5orf48	389320	broad.mit.edu	37	5	125968242	125968242	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:125968242G>A	ENST00000357147.3	+	2	104	c.91G>A	c.(91-93)Gaa>Aaa	p.E31K		NM_207408.1	NP_997291.1	Q6ZNM6	CE048_HUMAN	chromosome 5 open reading frame 48	31										large_intestine(1)|lung(1)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	7						CATCAGGTATGAAGAGATTCA	0.393000													15	23					0	0	1	0	0
COL3A1	1281	broad.mit.edu	37	2	189864581	189864581	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:189864581G>A	ENST00000304636.3	+	32	2413	c.2243G>A	c.(2242-2244)gGt>gAt	p.G748D	COL3A1_ENST00000317840.5_Missense_Mutation_p.G748D	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	748	Triple-helical region.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	GAACCAGGCGGTCCAGGTGCT	0.478000													8	7					0	0	1	0	0
PCDHB18P	54660	broad.mit.edu	37	5	140616288	140616288	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140616288C>T	ENST00000526308.1	+	0	2351					NR_001281.1															endometrium(9)|lung(7)|ovary(1)|urinary_tract(1)	18						AGGGCGGCCTCGATGGGTCGC	0.647000													69	124					0	0	1	0	0
NBPF20	100288142	broad.mit.edu	37	1	148346680	148346680	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:148346680G>A	ENST00000369202.1	-	2	274	c.77C>T	c.(76-78)cCc>cTc	p.P26L	NBPF20_ENST00000414710.2_Missense_Mutation_p.P26L					neuroblastoma breakpoint family, member 20											breast(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|urinary_tract(1)	27						TGCCAACTGGGGGCGCAATTT	0.502000													30	227					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90020788	90020788	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:90020788G>A	ENST00000405460.2	+	46	9984	c.9888G>A	c.(9886-9888)ggG>ggA	p.G3296G		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3296					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		GATGGCAGGGGATTTTTATTC	0.284000													11	14					0	0	1	0	0
ZBP1	81030	broad.mit.edu	37	20	56190614	56190614	+	Silent	SNP	T	T	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:56190614T>G	ENST00000371173.3	-	3	459	c.282A>C	c.(280-282)gcA>gcC	p.A94A	ZBP1_ENST00000343535.4_Silent_p.A94A|ZBP1_ENST00000340462.4_Intron|ZBP1_ENST00000538947.1_5'UTR|ZBP1_ENST00000541799.1_Silent_p.A94A|ZBP1_ENST00000395822.3_Silent_p.A19A	NM_001160417.1|NM_030776.2	NP_001153889.1|NP_110403.2	Q9H171	ZBP1_HUMAN	Z-DNA binding protein 1	94						cytoplasm|nucleus	double-stranded RNA adenosine deaminase activity|left-handed Z-DNA binding|RNA binding			large_intestine(11)|lung(8)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	27	Lung NSC(12;0.000545)|all_lung(29;0.00195)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;7.87e-13)|Epithelial(14;3.26e-09)|all cancers(14;3.62e-08)			GAATTGTAGCTGCATGTTGCT	0.592000													29	75					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39422666	39422666	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:39422666C>T	ENST00000280481.7	+	8	6454	c.6238C>T	c.(6238-6240)Cgt>Tgt	p.R2080C	FREM2_ENST00000482551.1_3'UTR	NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2080	Calx-beta 3.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GCAGCCTGTTCGTGTTGTCAT	0.478000													44	98					0	0	1	0	0
NLRP2	55655	broad.mit.edu	37	19	55497622	55497622	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:55497622G>A	ENST00000543010.1	+	8	2448	c.2305G>A	c.(2305-2307)Gat>Aat	p.D769N	NLRP2_ENST00000537859.1_Missense_Mutation_p.D747N|NLRP2_ENST00000538819.1_Missense_Mutation_p.D745N|NLRP2_ENST00000263437.6_Missense_Mutation_p.D766N|NLRP2_ENST00000391721.4_Missense_Mutation_p.D745N|NLRP2_ENST00000448584.2_Missense_Mutation_p.D769N|NLRP2_ENST00000339757.7_Missense_Mutation_p.D747N|NLRP2_ENST00000427260.2_Missense_Mutation_p.D746N	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	769					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		TGACCAGGATGATATGTTTCC	0.438000													14	32					0	0	1	0	0
NACA	4666	broad.mit.edu	37	12	57112047	57112047	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:57112047G>A	ENST00000454682.1	-	3	3548	c.3267C>T	c.(3265-3267)tcC>tcT	p.S1089S	NACA_ENST00000356769.3_Intron|NACA_ENST00000548563.1_Intron|NACA_ENST00000393891.4_Intron|NACA_ENST00000552540.1_Intron|NACA_ENST00000551793.1_Intron|NACA_ENST00000546392.1_Intron|NACA_ENST00000550952.1_Intron	NM_001113203.2	NP_001106674.2	Q13765	NACA_HUMAN	nascent polypeptide-associated complex alpha subunit	0					interspecies interaction between organisms|protein transport|transcription, DNA-dependent|translation	nascent polypeptide-associated complex|nucleus	DNA binding			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|upper_aerodigestive_tract(1)	10						CTCCTTTTGGGGAGGGAGGAG	0.662000			T	BCL6	NHL								28	47					0	0	1	0	0
KDM2B	84678	broad.mit.edu	37	12	121947466	121947466	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:121947466C>T	ENST00000377069.4	-	11	1864	c.1458G>A	c.(1456-1458)ctG>ctA	p.L486L	KDM2B_ENST00000542973.1_5'UTR|KDM2B_ENST00000536437.1_Silent_p.L400L|KDM2B_ENST00000377071.4_Silent_p.L517L|KDM2B_ENST00000538046.2_Silent_p.L427L	NM_001005366.1	NP_001005366.1	Q8NHM5	KDM2B_HUMAN	lysine (K)-specific demethylase 2B	517					embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	19						CCAGAGCTTTCAGGCCCTTCA	0.602000													42	34					0	0	1	0	0
CCDC108	255101	broad.mit.edu	37	2	219874667	219874667	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:219874667C>T	ENST00000341552.5	-	27	4532	c.4449G>A	c.(4447-4449)ggG>ggA	p.G1483G	AC097468.4_ENST00000441450.1_RNA|CCDC108_ENST00000441968.1_Silent_p.G1483G|CCDC108_ENST00000453220.1_Silent_p.G1483G	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	1483						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CTCTCACCTCCCCAAAATCTA	0.572000													12	21					0	0	1	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19203940	19203940	+	Silent	SNP	C	C	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:19203940C>G	ENST00000375341.3	-	10	1364	c.1107G>C	c.(1105-1107)ctG>ctC	p.L369L	ALDH4A1_ENST00000290597.5_Silent_p.L369L|RP13-279N23.2_ENST00000494072.3_3'UTR|ALDH4A1_ENST00000538839.1_Silent_p.L369L|ALDH4A1_ENST00000538309.1_Silent_p.L309L	NM_003748.3	NP_003739.2	P30038	AL4A1_HUMAN	aldehyde dehydrogenase 4 family, member A1	369					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity			cervix(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	TGTGCTCCTCCAGCAGCCGCC	0.682000													5	12					0	0	1	0	0
OR8B4	283162	broad.mit.edu	37	11	124294721	124294721	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:124294721C>T	ENST00000356130.3	-	1	68	c.47G>A	c.(46-48)gGa>gAa	p.G16E		NM_001005196.1	NP_001005196.1	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B, member 4	16					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(1)|urinary_tract(1)	32		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TTCTGATAATCCCACAAGGAT	0.473000													23	26					0	0	1	0	0
ESR1	2099	broad.mit.edu	37	6	152415538	152415538	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:152415538C>T	ENST00000440973.1	+	9	1758	c.1388C>T	c.(1387-1389)tCc>tTc	p.S463F	ESR1_ENST00000406599.1_Missense_Mutation_p.S202F|ESR1_ENST00000338799.5_Missense_Mutation_p.S463F|ESR1_ENST00000443427.1_Missense_Mutation_p.S463F|ESR1_ENST00000206249.3_Missense_Mutation_p.S463F|ESR1_ENST00000544394.1_Intron|ESR1_ENST00000456483.2_Missense_Mutation_p.S351F	NM_001122742.1	NP_001116214.1	P03372	ESR1_HUMAN	estrogen receptor 1	463	Interaction with AKAP13.|Steroid-binding.				positive regulation of retinoic acid receptor signaling pathway|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to estradiol stimulus	chromatin remodeling complex|cytoplasm|nucleoplasm	beta-catenin binding|enzyme binding|estrogen receptor activity|estrogen response element binding|nitric-oxide synthase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(1)|large_intestine(11)|lung(19)|ovary(1)|prostate(2)|skin(1)	49		Ovarian(120;0.0448)	BRCA - Breast invasive adenocarcinoma(37;0.0841)	OV - Ovarian serous cystadenocarcinoma(155;4.55e-10)	Chlorotrianisene(DB00269)|Clomifene(DB00882)|Conjugated Estrogens(DB00286)|Danazol(DB01406)|Desogestrel(DB00304)|Dienestrol(DB00890)|Diethylstilbestrol(DB00255)|Dromostanolone(DB00858)|Drospirenone(DB01395)|Estradiol(DB00783)|Estramustine(DB01196)|Estriol(DB04573)|Estrone(DB00655)|Ethinyl Estradiol(DB00977)|Ethynodiol Diacetate(DB00823)|Etonogestrel(DB00294)|Fluoxymesterone(DB01185)|Fulvestrant(DB00947)|Letrozole(DB01006)|Levonorgestrel(DB00367)|Medroxyprogesterone(DB00603)|Megestrol(DB00351)|Melatonin(DB01065)|Mestranol(DB01357)|Naloxone(DB01183)|Norgestimate(DB00957)|Norgestrel(DB00506)|Progesterone(DB00396)|Quinestrol(DB04575)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Toremifene(DB00539)	ACATTTCTGTCCAGCACCCTG	0.517000													42	100					0	0	1	0	0
TAS2R39	259285	broad.mit.edu	37	7	142880667	142880667	+	Silent	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:142880667T>C	ENST00000446620.1	+	1	156	c.156T>C	c.(154-156)aaT>aaC	p.N52N		NM_176881.2	NP_795362.2	P59534	T2R39_HUMAN	taste receptor, type 2, member 39	52					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20	Melanoma(164;0.059)					TCATTGCAAATGGTTTCATCA	0.413000													30	32					0	0	1	0	0
GLYCTK	132158	broad.mit.edu	37	3	52326387	52326387	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:52326387C>T	ENST00000354773.4	+	4	737	c.641C>T	c.(640-642)tCg>tTg	p.S214L	GLYCTK_ENST00000461183.1_Missense_Mutation_p.R189C|GLYCTK_ENST00000436784.2_Missense_Mutation_p.R273C|GLYCTK-AS1_ENST00000493616.1_RNA|GLYCTK_ENST00000305690.8_Missense_Mutation_p.R273C|GLYCTK_ENST00000477382.1_Missense_Mutation_p.S214L|GLYCTK_ENST00000473032.1_Intron|GLYCTK_ENST00000471180.1_Missense_Mutation_p.R146C	NM_001144951.1	NP_001138423.1	Q8IVS8	GLCTK_HUMAN	glycerate kinase	0					protein phosphorylation	Golgi apparatus|mitochondrion	ATP binding|glycerate kinase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|urinary_tract(1)	9				BRCA - Breast invasive adenocarcinoma(193;3.56e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)|OV - Ovarian serous cystadenocarcinoma(275;0.235)		TATCCTCAATCGCTACGGCCT	0.607000													18	34					0	0	1	0	0
DCDC1	341019	broad.mit.edu	37	11	31312269	31312269	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:31312269G>A	ENST00000597505.1	-	5	884	c.885C>T	c.(883-885)gtC>gtT	p.V295V	DCDC1_ENST00000452803.1_Silent_p.V295V			P59894	DCDC1_HUMAN	doublecortin domain containing 1	295					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					ACAGAATTCGGACTGAGGTCC	0.373000													10	38					0	0	1	0	0
SOCS1	8651	broad.mit.edu	37	16	11348859	11348859	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:11348859G>A	ENST00000332029.2	-	2	627	c.477C>T	c.(475-477)cgC>cgT	p.R159R	RMI2_ENST00000572173.1_Intron	NM_003745.1	NP_003736.1	O15524	SOCS1_HUMAN	suppressor of cytokine signaling 1	159	SH2.				interferon-gamma-mediated signaling pathway|JAK-STAT cascade|negative regulation of insulin receptor signaling pathway|negative regulation of tyrosine phosphorylation of Stat3 protein|regulation of growth|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytosol	insulin-like growth factor receptor binding|protein kinase binding|protein kinase inhibitor activity	p.F144fs*34(1)|p.Y64fs*1(1)|p.R127_*212del(1)|p.0?(1)|p.P158_M161del(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(66)|lung(3)	71						CCAGCATGCGGCGCGGCGCCG	0.731000			"""F, O"""		"""Hodgkin Lymphoma, PMBL"""								5	16					0	0	1	0	0
CLPP	8192	broad.mit.edu	37	19	6368633	6368633	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:6368633C>T	ENST00000245816.4	+	6	869	c.746C>T	c.(745-747)cCc>cTc	p.P249L	CLPP_ENST00000596605.1_3'UTR|CLPP_ENST00000596149.1_Missense_Mutation_p.P162L	NM_006012.2	NP_006003.1	Q16740	CLPP_HUMAN	caseinolytic mitochondrial matrix peptidase proteolytic subunit	249					proteolysis	mitochondrial matrix	ATP binding|protein binding|serine-type endopeptidase activity			endometrium(2)|large_intestine(2)|ovary(2)	6						GTCCACCCTCCCCAGGACGGT	0.632000													4	6					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229243	140229243	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140229243C>T	ENST00000378122.3	+	1	1887	c.1163C>T	c.(1162-1164)tCc>tTc	p.S388F	PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.S388F|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTTACCTGCTCCCTGACGCCC	0.562000													41	76					0	0	1	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41738568	41738568	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:41738568C>T	ENST00000352645.4	+	12	1490	c.1233C>T	c.(1231-1233)atC>atT	p.I411I	ZC3H7B_ENST00000351589.4_Silent_p.I411I	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	427					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						CCTTGCTCATCAAGAACCCCT	0.602000													27	19					0	0	1	0	0
SLC13A1	6561	broad.mit.edu	37	7	122759153	122759153	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:122759153G>A	ENST00000194130.2	-	13	1533	c.1494C>T	c.(1492-1494)ctC>ctT	p.L498L	SLC13A1_ENST00000539873.1_3'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	498						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	ATAATATTGGGAGAAAGAGTG	0.393000													15	20					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32621461	32621461	+	Silent	SNP	G	G	A	rs114216543	by1000genomes	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:32621461G>A	ENST00000338921.4	+	13	2005	c.1488G>A	c.(1486-1488)gaG>gaA	p.E496E	NRG1_ENST00000341377.5_3'UTR|NRG1_ENST00000405005.2_Silent_p.E488E|NRG1_ENST00000521670.1_3'UTR|NRG1_ENST00000287842.3_Silent_p.E485E|NRG1_ENST00000519301.1_Silent_p.E438E|NRG1_ENST00000287840.5_Silent_p.E488E|NRG1_ENST00000356819.4_Silent_p.E493E|NRG1_ENST00000287845.5_Silent_p.E459E|NRG1_ENST00000539990.1_Silent_p.E331E			Q02297	NRG1_HUMAN	neuregulin 1	488					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		GGCTGCGGGAGAAGAAGTTTG	0.577000													18	63					0	0	1	0	0
ADAMTS19	171019	broad.mit.edu	37	5	128956429	128956429	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:128956429G>A	ENST00000274487.4	+	9	1724	c.1579G>A	c.(1579-1581)Gaa>Aaa	p.E527K	CTC-575N7.1_ENST00000503616.1_RNA	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	527	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		ATGTAGCAAGGAAGATTTGGA	0.403000													77	83					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13886118	13886118	+	Nonsense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:13886118T>A	ENST00000265104.4	-	18	2802	c.2698A>T	c.(2698-2700)Aaa>Taa	p.K900*	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	900	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTGGATATTTTTTCACTTTCT	0.318000									Kartagener syndrome				13	10					0	0	1	0	0
IGHG1	3500	broad.mit.edu	37	14	106204046	106204046	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:106204046C>T	ENST00000390548.2	-	0	1252																											GAGCATGGCCCATGGCTGGTG	0.667000													25	2					0	0	1	0	0
UBL7	84993	broad.mit.edu	37	15	74742405	74742405	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:74742405A>C	ENST00000567435.1	-	7	999	c.536T>G	c.(535-537)gTg>gGg	p.V179G	UBL7_ENST00000564488.1_Missense_Mutation_p.V179G|UBL7_ENST00000361351.4_Missense_Mutation_p.V179G|UBL7_ENST00000565335.1_Missense_Mutation_p.V179G|UBL7_ENST00000395081.2_Missense_Mutation_p.V179G			Q96S82	UBL7_HUMAN	ubiquitin-like 7 (bone marrow stromal cell-derived)	179							protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)	9						GTGAGCAGGCACCAACCTAGG	0.577000													4	10					0	0	1	0	0
PLEKHM1P	440456	broad.mit.edu	37	17	62820837	62820837	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:62820837G>A	ENST00000582986.1	-	0	188					NR_024386.1																						GCCTCAGCTCGGATGTGCTTG	0.582000													13	13					0	0	1	0	0
SP140	11262	broad.mit.edu	37	2	231159024	231159024	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:231159024G>A	ENST00000392045.3	+	21	2121	c.2007G>A	c.(2005-2007)agG>agA	p.R669R	SP140_ENST00000350136.5_Silent_p.R538R|SP140_ENST00000417495.3_Silent_p.R555R|SP140_ENST00000420434.3_Silent_p.R642R|SP140_ENST00000343805.6_Silent_p.R609R|SP140_ENST00000486687.2_Silent_p.R593R	NM_007237.4	NP_009168.4	Q13342	LY10_HUMAN	SP140 nuclear body protein	669					defense response	cytoplasm|nuclear envelope|nucleolus|nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(1)	12		Renal(207;0.0112)|all_lung(227;0.0221)|Lung NSC(271;0.0977)|all_hematologic(139;0.103)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		TACGTTACAGGAAAAAAAAGG	0.373000													7	15					0	0	1	0	0
SLC39A3	29985	broad.mit.edu	37	19	2733091	2733091	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:2733091G>A	ENST00000269740.4	-	3	932	c.603C>T	c.(601-603)ttC>ttT	p.F201F	SLC39A3_ENST00000545664.1_Silent_p.F201F|AC006538.4_ENST00000586572.1_Intron	NM_144564.4	NP_653165.2	Q9BRY0	S39A3_HUMAN	solute carrier family 39 (zinc transporter), member 3	201						integral to membrane|plasma membrane	zinc ion transmembrane transporter activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	10		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACCCCCACGAACAGGCTCA	0.706000													47	72					0	0	1	0	0
CYP7B1	9420	broad.mit.edu	37	8	65528648	65528648	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:65528648C>T	ENST00000310193.3	-	3	623	c.450G>A	c.(448-450)ttG>ttA	p.L150L		NM_004820.3	NP_004811.1	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B, polypeptide 1	150					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(11)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	28		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				AGAGTATGTCCAAAGATTTGC	0.373000													13	27					0	0	1	0	0
CEACAM21	90273	broad.mit.edu	37	19	42083780	42083780	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:42083780G>A	ENST00000187608.9	+	2	333	c.293G>A	c.(292-294)cGa>cAa	p.R98Q	CEACAM21_ENST00000401445.2_Missense_Mutation_p.R98Q|CEACAM21_ENST00000407170.2_5'UTR|CEACAM21_ENST00000482870.2_3'UTR	NM_001098506.1|NM_033543.3	NP_001091976.1|NP_291021.2	Q3KPI0	CEA21_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 21	98						integral to membrane				endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	13						TACAGCGGTCGAGAGACAATA	0.488000													21	30					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74462256	74462256	+	Missense_Mutation	SNP	G	G	A	rs144083187		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:74462256G>A	ENST00000394019.2	-	22	2802	c.2405C>T	c.(2404-2406)cCc>cTc	p.P802L	SLC4A5_ENST00000346834.4_Missense_Mutation_p.P802L|SLC4A5_ENST00000359484.4_Intron|SLC4A5_ENST00000377632.1_Missense_Mutation_p.P802L|SLC4A5_ENST00000377634.4_Missense_Mutation_p.P802L|SLC4A5_ENST00000358683.4_Intron|SLC4A5_ENST00000423644.1_Missense_Mutation_p.P802L|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000357822.5_Missense_Mutation_p.P802L|RP11-287D1.3_ENST00000451608.2_3'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	802						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						ATGCAGCTTGGGAGTTTCTAG	0.547000													12	26					0	0	1	0	0
VWA2	340706	broad.mit.edu	37	10	116014795	116014795	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:116014795C>T	ENST00000603594.1	+	4	570	c.249C>T	c.(247-249)atC>atT	p.I83I	VWA2_ENST00000392982.3_Silent_p.I83I	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	83	VWFA 1.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		GTCTGGACATCAGCCCCGAGA	0.517000													58	34					0	0	1	0	0
RIMBP2	23504	broad.mit.edu	37	12	130935880	130935880	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:130935880C>T	ENST00000261655.4	-	5	476	c.313G>A	c.(313-315)Gag>Aag	p.E105K	RIMBP2_ENST00000536002.1_Missense_Mutation_p.E13K|RIMBP2_ENST00000535703.1_Missense_Mutation_p.E13K	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	105						cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		ATAGCGCTCTCCTGACCTGGC	0.562000													20	19					0	0	1	0	0
MIP	4284	broad.mit.edu	37	12	56848293	56848293	+	Silent	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:56848293A>T	ENST00000257979.4	-	1	133	c.105T>A	c.(103-105)gcT>gcA	p.A35A	MIP_ENST00000555551.1_Intron	NM_012064.3	NP_036196.1	P30301	MIP_HUMAN	major intrinsic protein of lens fiber	35					response to stimulus|visual perception	gap junction|integral to plasma membrane	structural constituent of eye lens			kidney(1)|large_intestine(2)|lung(8)|prostate(1)|skin(3)|urinary_tract(1)	16						GGGGTCCAGGAGCCCAGCGCA	0.582000													15	68					0	0	1	0	0
BRD8	10902	broad.mit.edu	37	5	137500059	137500059	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:137500059G>A	ENST00000254900.5	-	13	2146	c.1775C>T	c.(1774-1776)cCc>cTc	p.P592L	BRD8_ENST00000411594.2_Missense_Mutation_p.P595L|BRD8_ENST00000402931.1_Missense_Mutation_p.P592L|BRD8_ENST00000230901.5_Missense_Mutation_p.P665L|BRD8_ENST00000455658.2_Missense_Mutation_p.P551L|BRD8_ENST00000515014.1_5'UTR	NM_139199.1	NP_631938.1	Q9H0E9	BRD8_HUMAN	bromodomain containing 8	592					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(3)|urinary_tract(1)	35			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			ATCTTCAATGGGATTTGAGCC	0.408000													31	50					0	0	1	0	0
NYAP1	222950	broad.mit.edu	37	7	100086477	100086477	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:100086477G>A	ENST00000423930.1	+	4	1292	c.1133G>A	c.(1132-1134)cGg>cAg	p.R378Q	NYAP1_ENST00000300179.2_Missense_Mutation_p.R378Q|NYAP1_ENST00000454988.1_Missense_Mutation_p.R321Q			Q6ZVC0	CG051_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1	378	Pro-rich.																GTGCCTGCACGGGAGCGGGAG	0.697000													22	49					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117391964	117391964	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:117391964C>T	ENST00000321322.6	-	6	1275	c.1274G>A	c.(1273-1275)gGg>gAg	p.G425E	DSCAML1_ENST00000527706.1_Missense_Mutation_p.G155E	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	365	Ig-like C2-type 5.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		GTTGCTGAGCCCGCGGATGGA	0.642000													61	94					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41161821	41161821	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:41161821C>T	ENST00000263413.3	-	10	1696	c.1432G>A	c.(1432-1434)Gaa>Aaa	p.E478K	C6_ENST00000475349.1_5'UTR|C6_ENST00000337836.5_Missense_Mutation_p.E478K	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	478	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				GCAGGATTTTCCTTCACTGAT	0.428000													41	92					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38427202	38427202	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:38427202C>T	ENST00000322350.5	+	14	2248	c.1902C>T	c.(1900-1902)ttC>ttT	p.F634F	EGFLAM_ENST00000354891.3_Silent_p.F634F|EGFLAM_ENST00000397202.2_5'UTR|EGFLAM_ENST00000336740.6_Silent_p.F400F|EGFLAM-AS1_ENST00000508986.1_RNA	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	634	Laminin G-like 2.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					ACCTTTCCTTCATGGAATTTG	0.493000													52	132					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128307008	128307008	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:128307008C>T	ENST00000368227.3	-	23	3526	c.3160G>A	c.(3160-3162)Gaa>Aaa	p.E1054K	PTPRK_ENST00000368210.3_Missense_Mutation_p.E1055K|PTPRK_ENST00000368207.3_Missense_Mutation_p.E1069K|PTPRK_ENST00000368226.4_Missense_Mutation_p.E1037K|PTPRK_ENST00000532331.1_Missense_Mutation_p.E1059K|PTPRK_ENST00000368213.5_Missense_Mutation_p.E1043K|PTPRK_ENST00000368215.3_Missense_Mutation_p.E1036K			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1036	Tyrosine-protein phosphatase 1.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TCACGGATTTCATTGTACCCC	0.443000													16	35					0	0	1	0	0
OR5M1	390168	broad.mit.edu	37	11	56380921	56380921	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:56380921C>T	ENST00000526538.1	-	1	57	c.58G>A	c.(58-60)Gac>Aac	p.D20N		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.D20N(1)		central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						AGCACTGGGTCGTCTGTCAGT	0.458000													43	51					0	0	1	0	0
FFAR3	2865	broad.mit.edu	37	19	35849901	35849901	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:35849901G>T	ENST00000327809.4	+	2	310	c.109G>T	c.(109-111)Gtg>Ttg	p.V37L	FFAR3_ENST00000594310.1_Missense_Mutation_p.V37L	NM_005304.3	NP_005295.1	O14843	FFAR3_HUMAN	free fatty acid receptor 3	37						integral to plasma membrane	G-protein coupled receptor activity|lipid binding			endometrium(3)|large_intestine(2)|lung(9)|ovary(1)|skin(1)|stomach(1)	17	all_lung(56;9.78e-09)|Lung NSC(56;1.46e-08)|Esophageal squamous(110;0.162)		Epithelial(14;1.29e-19)|OV - Ovarian serous cystadenocarcinoma(14;4.63e-18)|all cancers(14;5.19e-17)|LUSC - Lung squamous cell carcinoma(66;0.0221)			GCTGGCCCTGGTGGTCTTCGT	0.642000													48	175					2.48254e-18	2.51445e-18	1	1	0
SEC31B	25956	broad.mit.edu	37	10	102262131	102262131	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:102262131G>A	ENST00000370345.3	-	11	1387	c.1290C>T	c.(1288-1290)ttC>ttT	p.F430F	SEC31B_ENST00000451524.1_Silent_p.F430F	NM_015490.3	NP_056305.1	Q9NQW1	SC31B_HUMAN	SEC31 homolog B (S. cerevisiae)	430					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(3)|lung(17)|ovary(1)|urinary_tract(1)	36		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		ATCGCATCAGGAATTCAGATT	0.517000													21	26					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38622577	38622577	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:38622577C>T	ENST00000413689.1	-	17	3266	c.3073G>A	c.(3073-3075)Gaa>Aaa	p.E1025K	SCN5A_ENST00000425664.1_Missense_Mutation_p.E1025K|SCN5A_ENST00000443581.1_Missense_Mutation_p.E1025K|SCN5A_ENST00000414099.2_Missense_Mutation_p.E1025K|SCN5A_ENST00000450102.2_Missense_Mutation_p.E1025K|SCN5A_ENST00000455624.2_Missense_Mutation_p.E1025K|SCN5A_ENST00000449557.2_Missense_Mutation_p.E1025K|SCN5A_ENST00000423572.2_Missense_Mutation_p.E1025K|SCN5A_ENST00000451551.2_Missense_Mutation_p.E1025K|SCN5A_ENST00000333535.4_Missense_Mutation_p.E1025K	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1025					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	AACCGTGTTTCCTTGCGGGTG	0.682000													8	28					0	0	1	0	0
C14orf177	283598	broad.mit.edu	37	14	99182645	99182645	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:99182645G>A	ENST00000325812.2	+	3	536	c.117G>A	c.(115-117)ggG>ggA	p.G39G		NM_182560.2	NP_872366.2	Q52M58	CN177_HUMAN	chromosome 14 open reading frame 177	39										endometrium(1)|kidney(1)|large_intestine(1)|lung(10)	13		Melanoma(154;0.128)				TTGGTGAAGGGAAATGCCCAA	0.552000													25	7					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107029606	107029606	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:107029606G>A	ENST00000409886.3	-	22	5287	c.5200C>T	c.(5200-5202)Cct>Tct	p.P1734S	RGPD3_ENST00000304514.7_Missense_Mutation_p.P1734S	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	1734	GRIP.				intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TTTATAACAGGAAGAAGTCTC	0.448000													62	92					0	0	1	0	0
OR4K2	390431	broad.mit.edu	37	14	20345121	20345121	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:20345121G>A	ENST00000298642.2	+	1	731	c.695G>A	c.(694-696)gGa>gAa	p.G232E		NM_001005501.1	NP_001005501.1	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K, member 2	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(16)|ovary(2)|skin(9)|upper_aerodigestive_tract(2)	43	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTTCCAGAGGATCATCTAAG	0.383000													65	39					0	0	1	0	0
PNLDC1	154197	broad.mit.edu	37	6	160239611	160239611	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:160239611C>T	ENST00000275275.5	+	16	1320	c.1149C>T	c.(1147-1149)tcC>tcT	p.S383S	PNLDC1_ENST00000392167.3_Silent_p.S394S	NM_001271862.1|NM_173516.1	NP_001258791.1|NP_775787.1	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain containing 1	383						integral to membrane|nucleus	nucleic acid binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	31		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CCGAGTCATCCTTTCCTCAGT	0.567000													15	74					0	0	1	0	0
DYSF	8291	broad.mit.edu	37	2	71901333	71901333	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:71901333T>C	ENST00000258104.3	+	51	5951	c.5674T>C	c.(5674-5676)Ttc>Ctc	p.F1892L	DYSF_ENST00000409582.3_Missense_Mutation_p.F1930L|DYSF_ENST00000409744.1_Missense_Mutation_p.F1900L|DYSF_ENST00000409651.1_Missense_Mutation_p.F1924L|DYSF_ENST00000429174.2_Missense_Mutation_p.F1913L|DYSF_ENST00000413539.2_Missense_Mutation_p.F1923L|DYSF_ENST00000410020.3_Missense_Mutation_p.F1931L|DYSF_ENST00000410041.1_Missense_Mutation_p.F1910L|DYSF_ENST00000409762.1_Missense_Mutation_p.F1909L|DYSF_ENST00000479049.2_3'UTR|DYSF_ENST00000409366.1_Missense_Mutation_p.F1914L|DYSF_ENST00000394120.2_Missense_Mutation_p.F1893L	NM_001130976.1|NM_003494.3	NP_001124448.1|NP_003485.1	O75923	DYSF_HUMAN	dysferlin	1892						cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			autonomic_ganglia(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(57)|ovary(3)|pancreas(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(2)	111						TCAGGATGCCTTCTGGAGGCT	0.532000													22	33					0	0	1	0	0
ERCC6-PGBD3	101243544	broad.mit.edu	37	10	50724338	50724338	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:50724338G>A	ENST00000515869.1	-	6	2347	c.2227C>T	c.(2227-2229)Cct>Tct	p.P743S	ERCC6_ENST00000355832.5_Intron|PGBD3_ENST00000374127.3_Missense_Mutation_p.P275S|ERCC6-PGBD3_ENST00000447839.2_Missense_Mutation_p.P743S|PGBD3_ENST00000603152.1_Missense_Mutation_p.P743S|PGBD3_ENST00000508005.2_Missense_Mutation_p.P275S	NM_001277059.1	NP_001263988.1																					CCAAAATAAGGAACCATGAAT	0.398000													9	10					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42045560	42045560	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:42045560G>A	ENST00000372584.1	-	3	5923	c.4909C>T	c.(4909-4911)Ccc>Tcc	p.P1637S	HIVEP3_ENST00000460604.1_5'UTR|HIVEP3_ENST00000429157.2_Missense_Mutation_p.P1637S|HIVEP3_ENST00000372583.1_Missense_Mutation_p.P1637S|HIVEP3_ENST00000247584.5_Missense_Mutation_p.P1637S	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1637					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GGAAGGTTGGGGTTGTACAAA	0.483000													14	76					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74573043	74573043	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:74573043C>T	ENST00000321288.5	+	11	1533	c.1533C>T	c.(1531-1533)ccC>ccT	p.P511P	CCDC33_ENST00000398814.3_Silent_p.P308P			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	511							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						TCAACCAGCCCCTGGGCATCT	0.597000													29	76					0	0	1	0	0
SIM1	6492	broad.mit.edu	37	6	100838605	100838605	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:100838605C>T	ENST00000369208.3	-	12	2715	c.1933G>A	c.(1933-1935)Gaa>Aaa	p.E645K	SIM1_ENST00000262901.4_Missense_Mutation_p.E645K			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	645	Single-minded C-terminal.				cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		TAGTCATTTTCATGGGGGCTC	0.478000													33	185					0	0	1	0	0
BTK	695	broad.mit.edu	37	X	100630261	100630261	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:100630261C>T	ENST00000308731.7	-	2	175	c.12G>A	c.(10-12)gtG>gtA	p.V4V	BTK_ENST00000464567.1_5'UTR|BTK_ENST00000372880.1_Silent_p.V4V	NM_000061.2	NP_000052.1	Q06187	BTK_HUMAN	Bruton agammaglobulinemia tyrosine kinase	4	PH.				calcium-mediated signaling|induction of apoptosis by extracellular signals|mesoderm development	cytosol|membrane raft|nucleus|plasma membrane	ATP binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol-3,4,5-trisphosphate binding			breast(4)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(25)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TCTCCAGAATCACTGCGGCCA	0.458000									Agammaglobulinemia, X-linked				55	17					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84526289	84526289	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:84526289C>T	ENST00000360700.4	+	10	2765	c.1879C>T	c.(1879-1881)Ctg>Ttg	p.L627L	ZNF711_ENST00000276123.3_Silent_p.L581L|ZNF711_ENST00000395402.1_Silent_p.L589L|ZNF711_ENST00000373165.3_Silent_p.L581L|ZNF711_ENST00000542798.1_Silent_p.L423L			Q9Y462	ZN711_HUMAN	zinc finger protein 711	581					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						TCAACGCCATCTGGATTTGTT	0.418000													10	2					0	0	1	0	0
LPHN2	23266	broad.mit.edu	37	1	82432220	82432220	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:82432220C>T	ENST00000370728.1	+	15	2909	c.2264C>T	c.(2263-2265)tCa>tTa	p.S755L	LPHN2_ENST00000359929.3_Missense_Mutation_p.S742L|LPHN2_ENST00000271029.4_Missense_Mutation_p.S755L|LPHN2_ENST00000370725.1_Missense_Mutation_p.S755L|LPHN2_ENST00000370727.1_Missense_Mutation_p.S755L|LPHN2_ENST00000319517.6_Missense_Mutation_p.S742L|LPHN2_ENST00000394879.1_Missense_Mutation_p.S742L|LPHN2_ENST00000370723.1_Missense_Mutation_p.S742L|LPHN2_ENST00000370721.1_Missense_Mutation_p.S680L|LPHN2_ENST00000370713.1_Missense_Mutation_p.S742L|LPHN2_ENST00000335786.5_Missense_Mutation_p.S755L|LPHN2_ENST00000370717.2_Missense_Mutation_p.S755L|LPHN2_ENST00000469377.2_Intron|LPHN2_ENST00000370715.1_Missense_Mutation_p.S742L|LPHN2_ENST00000370730.1_Missense_Mutation_p.S755L			O95490	LPHN2_HUMAN	latrophilin 2	755					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|latrotoxin receptor activity|sugar binding	p.S755L(1)|p.S742L(1)		NS(3)|breast(6)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(18)|liver(2)|lung(37)|ovary(3)|pancreas(1)|prostate(3)|skin(22)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	119				all cancers(265;0.00142)|Epithelial(280;0.00829)|OV - Ovarian serous cystadenocarcinoma(397;0.077)|STAD - Stomach adenocarcinoma(256;0.248)		CACGTCATTTCAGTTTCAATC	0.403000													27	137					0	0	1	0	0
SND1	27044	broad.mit.edu	37	7	127569268	127569268	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:127569268C>T	ENST00000354725.3	+	15	1749	c.1555C>T	c.(1555-1557)Cct>Tct	p.P519S		NM_014390.2	NP_055205.2	Q7KZF4	SND1_HUMAN	staphylococcal nuclease and tudor domain containing 1	519					gene silencing by RNA|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	melanosome|nucleus|RNA-induced silencing complex	nuclease activity|nucleic acid binding|protein binding|transcription cofactor activity			central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(15)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	41						GCAGTTCCTGCCTTTTCTTCA	0.428000													45	57					0	0	1	0	0
ERI1	90459	broad.mit.edu	37	8	8887305	8887305	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:8887305C>T	ENST00000523898.1	+	8	1490	c.811C>T	c.(811-813)Cct>Tct	p.P271S	ERI1_ENST00000250263.7_Missense_Mutation_p.P271S|ERI1_ENST00000519292.1_Missense_Mutation_p.P271S|ERI1_ENST00000520332.1_Intron			Q8IV48	ERI1_HUMAN	exoribonuclease 1	271	Exonuclease.				gene silencing by RNA|rRNA 3'-end processing	cytoplasm|histone pre-mRNA 3'end processing complex|nucleolus	3'-5' exonuclease activity|histone pre-mRNA stem-loop binding|metal ion binding|ribosome binding|rRNA binding			NS(1)|endometrium(2)|large_intestine(1)|lung(6)|prostate(1)	11					Adenosine monophosphate(DB00131)	TTTTCAGGTTCCTAGAAGCCA	0.353000													20	32					0	0	1	0	0
LZTS3	9762	broad.mit.edu	37	20	3145151	3145151	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:3145151C>A	ENST00000329152.3	-	3	3368	c.1971G>T	c.(1969-1971)aaG>aaT	p.K657N	LZTS3_ENST00000360342.3_Missense_Mutation_p.K611N|LZTS3_ENST00000337576.5_Missense_Mutation_p.K611N	NM_014731.2	NP_055546.1																					TCCAGGCCTTCTTCTCCTCGC	0.637000													17	43					4.7546e-09	4.79024e-09	1	1	0
LRP2	4036	broad.mit.edu	37	2	170058150	170058150	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:170058150C>T	ENST00000263816.3	-	44	8725	c.8440G>A	c.(8440-8442)Gag>Aag	p.E2814K		NM_004525.2	NP_004516.2	P98164	LRP2_HUMAN	low density lipoprotein receptor-related protein 2	2814	LDL-receptor class A 18.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CAATTTTTCTCATCTGAAGTG	0.368000													19	32					0	0	1	0	0
MUC7	4589	broad.mit.edu	37	4	71347402	71347402	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:71347402C>T	ENST00000413702.1	+	4	1229	c.941C>T	c.(940-942)tCc>tTc	p.S314F	MUC7_ENST00000456088.1_Missense_Mutation_p.S314F|MUC7_ENST00000304887.5_Missense_Mutation_p.S314F	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	314	Thr-rich.					extracellular region	protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			CCTAATTCTTCCCCAACTACT	0.512000													146	86					0	0	1	0	0
COL4A3BP	10087	broad.mit.edu	37	5	74677788	74677788	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:74677788G>A	ENST00000380494.5	-	16	2280	c.1987C>T	c.(1987-1989)Cat>Tat	p.H663Y	COL4A3BP_ENST00000508692.1_5'UTR|COL4A3BP_ENST00000261415.7_Missense_Mutation_p.H509Y|COL4A3BP_ENST00000405807.4_Missense_Mutation_p.H535Y	NM_001130105.1	NP_001123577.1	Q9Y5P4	C43BP_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen) binding protein	535					ER to Golgi ceramide transport|immune response	cytosol|endoplasmic reticulum membrane|Golgi apparatus	ceramide binding|phosphatidylinositol-4-phosphate binding|protein binding|protein kinase activity			breast(1)|kidney(1)|large_intestine(5)|lung(4)|skin(3)|stomach(1)|urinary_tract(1)	16		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Prostate(461;0.174)		OV - Ovarian serous cystadenocarcinoma(47;1e-53)		GCACTGTCATGATCCACAGAA	0.343000													10	12					0	0	1	0	0
PYROXD1	79912	broad.mit.edu	37	12	21614955	21614955	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:21614955C>T	ENST00000538582.1	+	9	1434	c.681C>T	c.(679-681)gtC>gtT	p.V227V	PYROXD1_ENST00000545178.1_3'UTR|PYROXD1_ENST00000240651.9_Silent_p.V298V			Q8WU10	PYRD1_HUMAN	pyridine nucleotide-disulphide oxidoreductase domain 1	298							oxidoreductase activity			endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(2)|soft_tissue(1)	18						TGTGGCCTGTCTATGTGGAAT	0.368000													7	29					0	0	1	0	0
TOP3A	7156	broad.mit.edu	37	17	18181326	18181326	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:18181326G>A	ENST00000321105.5	-	18	2704	c.2490C>T	c.(2488-2490)aaC>aaT	p.N830N	TOP3A_ENST00000542570.1_Silent_p.N735N|TOP3A_ENST00000540524.1_Silent_p.N360N	NM_004618.3	NP_004609.1	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	830	2 X 27 AA approximate repeats.				DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|ovary(1)|skin(6)|stomach(2)|urinary_tract(1)	36						GCCGGCCCCGGTTGGGGCCCT	0.617000													48	17					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93800916	93800916	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:93800916G>A	ENST00000315765.9	+	5	1071	c.1063_splice	c.e5+1	p.A355_splice		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	355	Plastocyanin-like 2.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				CCACCTACAAGGTAAAAAGGA	0.453000													11	24					0	0	1	0	0
HMGCLL1	54511	broad.mit.edu	37	6	55378918	55378918	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:55378918G>A	ENST00000398661.2	-	6	691	c.560C>T	c.(559-561)tCc>tTc	p.S187F	HMGCLL1_ENST00000508459.1_Intron|HMGCLL1_ENST00000274901.4_Missense_Mutation_p.S157F|HMGCLL1_ENST00000308161.4_Missense_Mutation_p.S125F|HMGCLL1_ENST00000428842.1_Missense_Mutation_p.S125F|HMGCLL1_ENST00000370850.2_Intron	NM_019036.2	NP_061909.2	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1	187							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	31	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			TTCTTCAATGGAACAGTTAAT	0.368000													16	43					0	0	1	0	0
UBE2O	63893	broad.mit.edu	37	17	74392713	74392713	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:74392713G>A	ENST00000319380.7	-	14	2369	c.2305C>T	c.(2305-2307)Cct>Tct	p.P769S		NM_022066.3	NP_071349.3	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	769							ATP binding|ubiquitin-protein ligase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(17)|ovary(2)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36						TTGTCCTCAGGGGCCACCGGC	0.652000													68	88					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50278490	50278490	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:50278490G>A	ENST00000442544.2	+	2	774	c.158G>A	c.(157-159)cGg>cAg	p.R53Q		NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	53	Ig-like C2-type 1.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GTCACAATGCGGGGAGGAAAT	0.502000													25	27					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142651457	142651457	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:142651457G>A	ENST00000355265.2	-	8	1212	c.738C>T	c.(736-738)atC>atT	p.I246I	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	246					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					ATTCCCGAAAGATCTGGAGGA	0.532000													25	37					0	0	1	0	0
OR51M1	390059	broad.mit.edu	37	11	5410947	5410947	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:5410947G>A	ENST00000328611.3	+	1	341	c.319G>A	c.(319-321)Gga>Aga	p.G107R	HBG2_ENST00000380259.2_Intron|AC104389.28_ENST00000415970.1_RNA|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_001004756.2	NP_001004756.2	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M, member 1	107						integral to membrane	olfactory receptor activity			NS(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|upper_aerodigestive_tract(1)	30		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TATCTACTTTGGAGCGTGTCA	0.512000													76	119					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3224583	3224583	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:3224583G>A	ENST00000602557.1	-	21	3644	c.3089C>T	c.(3088-3090)tCg>tTg	p.S1030L	CSMD1_ENST00000602723.1_Missense_Mutation_p.S1030L|CSMD1_ENST00000520002.1_Missense_Mutation_p.S1030L|CSMD1_ENST00000542608.1_Missense_Mutation_p.S1029L|CSMD1_ENST00000400186.3_Missense_Mutation_p.S1030L|CSMD1_ENST00000539096.1_Missense_Mutation_p.S1029L|CSMD1_ENST00000537824.1_Missense_Mutation_p.S1029L			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1030	CUB 6.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCCCTCGTACGAAATTGAGAA	0.468000													10	17					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41010076	41010076	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:41010076G>A	ENST00000399564.4	-	31	3691	c.3241C>T	c.(3241-3243)Cac>Tac	p.H1081Y	MROH2B_ENST00000506092.2_Missense_Mutation_p.H636Y	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		GTATCCATGTGAAAGCTGGCT	0.438000													16	45					0	0	1	0	0
MROH7	374977	broad.mit.edu	37	1	55167785	55167785	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:55167785C>T	ENST00000414150.2	+	20	3586	c.3308C>T	c.(3307-3309)tCc>tTc	p.S1103F	MROH7_ENST00000421030.2_Missense_Mutation_p.S1103F|MROH7_ENST00000409996.1_Missense_Mutation_p.S671F|MROH7_ENST00000454855.2_Missense_Mutation_p.S621F					maestro heat-like repeat family member 7									p.S1103F(1)|p.S1100F(1)									GTGCGCTCCTCCTGCATCAAC	0.622000													23	12					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	2944702	2944702	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:2944702C>T	ENST00000602557.1	-	50	7949	c.7394G>A	c.(7393-7395)cGa>cAa	p.R2465Q	CSMD1_ENST00000602723.1_Missense_Mutation_p.R2465Q|CSMD1_ENST00000520002.1_Missense_Mutation_p.R2465Q|CSMD1_ENST00000542608.1_Missense_Mutation_p.R2464Q|CSMD1_ENST00000400186.3_Missense_Mutation_p.R2465Q|CSMD1_ENST00000537824.1_Missense_Mutation_p.R2464Q			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	2465	Sushi 14.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCCGACCATTCGGTATCCAGG	0.517000													21	40					0	0	1	0	0
DCST2	127579	broad.mit.edu	37	1	155005955	155005955	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:155005955G>A	ENST00000368424.3	-	1	281	c.223C>T	c.(223-225)Cag>Tag	p.Q75*	DCST2_ENST00000295536.5_Nonsense_Mutation_p.Q75*	NM_144622.2	NP_653223.2	Q5T1A1	DCST2_HUMAN	DC-STAMP domain containing 2	75						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|prostate(1)|skin(1)	38	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			GCTCGGACCTGGCGAGAGAAT	0.657000													66	40					0	0	1	0	0
CXCR5	643	broad.mit.edu	37	11	118764554	118764554	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:118764554G>A	ENST00000292174.4	+	2	477	c.301G>A	c.(301-303)Gtc>Atc	p.V101I		NM_001716.4|NM_032966.2	NP_001707.1|NP_116743.1	P32302	CXCR5_HUMAN	chemokine (C-X-C motif) receptor 5	101					B cell activation|cellular component movement	integral to plasma membrane	C-X-C chemokine receptor activity			breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(5)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.62e-05)		CCTCCTGCTGGTCTTCATCTT	0.617000													37	43					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82546104	82546104	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:82546104G>A	ENST00000423517.2	-	7	11535	c.11198C>T	c.(11197-11199)tCc>tTc	p.S3733F	PCLO_ENST00000333891.8_Missense_Mutation_p.S3733F|PCLO_ENST00000437081.1_Missense_Mutation_p.S453F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	3664					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						AGTTCCTGTGGAAATCTCCTC	0.443000													36	43					0	0	1	0	0
KCNQ1	3784	broad.mit.edu	37	11	2683248	2683248	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:2683248G>A	ENST00000155840.5	+	11	1559	c.1451G>A	c.(1450-1452)aGc>aAc	p.S484N	KCNQ1OT1_ENST00000597346.1_RNA|KCNQ1_ENST00000335475.5_Missense_Mutation_p.S357N	NM_000218.2	NP_000209.2	P51787	KCNQ1_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 1	484					blood circulation|membrane depolarization|muscle contraction|sensory perception of sound		delayed rectifier potassium channel activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(2)	21		all_epithelial(84;3.26e-05)|Breast(177;0.001)|Medulloblastoma(188;0.00111)|Ovarian(85;0.00158)|all_neural(188;0.00725)|all_lung(207;0.11)|Lung NSC(207;0.159)		BRCA - Breast invasive adenocarcinoma(625;0.00251)|Lung(200;0.131)	Bepridil(DB01244)|Indapamide(DB00808)	AGAACCAACAGCTTCGCCGAG	0.577000													68	84					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577099	7577099	+	Missense_Mutation	SNP	C	C	T	rs121912660		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:7577099C>T	ENST00000420246.2	-	8	971	c.839G>A	c.(838-840)aGa>aAa	p.R280K	TP53_ENST00000359597.4_Missense_Mutation_p.R280K|TP53_ENST00000413465.2_Intron|TP53_ENST00000445888.2_Missense_Mutation_p.R280K|TP53_ENST00000269305.4_Missense_Mutation_p.R280K|TP53_ENST00000455263.2_Missense_Mutation_p.R280K	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	280	Interaction with AXIN1 (By similarity).|Interaction with DNA.|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		R -> G (in sporadic cancers; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).|R -> T (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(65)|p.R280K(49)|p.R280I(16)|p.0?(8)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.G279_R280delGR(1)|p.F270_D281del12(1)|p.G279fs*59(1)|p.D281fs*24(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			19	5					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204957842	204957842	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:204957842C>T	ENST00000367172.4	+	25	3324	c.2996C>T	c.(2995-2997)cCc>cTc	p.P999L	NFASC_ENST00000404076.1_Missense_Mutation_p.P978L|NFASC_ENST00000495396.1_3'UTR|NFASC_ENST00000401399.1_Missense_Mutation_p.P892L|NFASC_ENST00000338586.6_Missense_Mutation_p.P999L|NFASC_ENST00000404907.1_Missense_Mutation_p.P995L|NFASC_ENST00000338515.6_Missense_Mutation_p.P999L|NFASC_ENST00000513543.1_Missense_Mutation_p.P995L|NFASC_ENST00000367169.4_Missense_Mutation_p.P892L|NFASC_ENST00000367171.4_Missense_Mutation_p.P984L|NFASC_ENST00000367170.4_Missense_Mutation_p.P999L|NFASC_ENST00000339876.6_Missense_Mutation_p.P892L|NFASC_ENST00000539706.1_Missense_Mutation_p.P995L|NFASC_ENST00000360049.4_Missense_Mutation_p.P995L			O94856	NFASC_HUMAN	neurofascin	999	Fibronectin type-III 4.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGAACGGACCCCGTGTCACGC	0.567000													19	108					0	0	1	0	0
GTSF1L	149699	broad.mit.edu	37	20	42355047	42355047	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:42355047G>A	ENST00000373003.1	-	1	591	c.288C>T	c.(286-288)ccC>ccT	p.P96P	GTSF1L_ENST00000373005.2_Intron	NM_001008901.1|NM_176791.3	NP_001008901.1|NP_789761.1	Q9H1H1	GTSFL_HUMAN	gametocyte specific factor 1-like	96							metal ion binding			endometrium(1)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	5		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TGGGAAGGCAGGGTGAGACCT	0.498000													15	50					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	40770568	40770568	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:40770568C>T	ENST00000373198.3	-	19	3058	c.2823G>A	c.(2821-2823)ggG>ggA	p.G941G	PTPRT_ENST00000373201.1_Silent_p.G909G|PTPRT_ENST00000373187.1_Silent_p.G919G|PTPRT_ENST00000373193.3_Silent_p.G922G|PTPRT_ENST00000373184.1_Silent_p.G909G|PTPRT_ENST00000373190.1_Silent_p.G918G|PTPRT_ENST00000356100.2_Silent_p.G928G	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	919	Tyrosine-protein phosphatase 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ATATGATGTTCCCATATCGAT	0.473000													61	137					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	121981132	121981132	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:121981132C>T	ENST00000498619.1	+	4	1688	c.1250C>T	c.(1249-1251)tCc>tTc	p.S417F	CASR_ENST00000490131.1_Missense_Mutation_p.S417F|CASR_ENST00000296154.5_Missense_Mutation_p.S417F	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	417					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TTACGGATATCCTACAATGTG	0.493000													31	43					0	0	1	0	0
CACHD1	57685	broad.mit.edu	37	1	65138896	65138896	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:65138896C>T	ENST00000371073.2	+	18	2566	c.2566C>T	c.(2566-2568)Ccc>Tcc	p.P856S	CACHD1_ENST00000495994.1_3'UTR|CACHD1_ENST00000290039.5_Missense_Mutation_p.P805S			Q5VU97	CAHD1_HUMAN	cache domain containing 1	856					calcium ion transport	integral to membrane				breast(4)|endometrium(3)|kidney(3)|large_intestine(20)|lung(14)|ovary(2)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55						TCTCATCGACCCCAAAGGACA	0.502000													37	181					0	0	1	0	0
RAB40C	57799	broad.mit.edu	37	16	640424	640424	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:640424T>C	ENST00000535977.1	+	2	355	c.133T>C	c.(133-135)Tac>Cac	p.Y45H	RAB40C_ENST00000248139.3_Missense_Mutation_p.Y45H|RAB40C_ENST00000538492.1_Missense_Mutation_p.Y45H|RAB40C_ENST00000539661.1_Missense_Mutation_p.Y45H	NM_001172663.1	NP_001166134.1	Q96S21	RB40C_HUMAN	RAB40C, member RAS oncogene family	45					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			NS(1)|endometrium(2)|large_intestine(1)|lung(1)|prostate(1)	6		Hepatocellular(780;0.0218)				CCCGTACGCCTACAGTAACGG	0.726000													6	18					0	0	1	0	0
ADRA1A	148	broad.mit.edu	37	8	26628180	26628180	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:26628180G>A	ENST00000380573.3	-	3	1910	c.887C>T	c.(886-888)tCt>tTt	p.S296F	ADRA1A_ENST00000354550.4_Missense_Mutation_p.S296F|ADRA1A_ENST00000276393.4_Missense_Mutation_p.S296F|ADRA1A_ENST00000519229.1_Missense_Mutation_p.S296F|ADRA1A_ENST00000380582.3_Missense_Mutation_p.S296F|ADRA1A_ENST00000380587.1_Intron|ADRA1A_ENST00000380586.1_Missense_Mutation_p.S296F|ADRA1A_ENST00000380581.2_Intron			P35348	ADA1A_HUMAN	adrenoceptor alpha 1A	296					activation of phospholipase C activity|aging|apoptosis|calcium ion transport into cytosol|cell-cell signaling|intracellular protein kinase cascade|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of synaptic transmission, GABAergic|positive regulation of action potential|positive regulation of cardiac muscle contraction|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein kinase C signaling cascade|positive regulation of vasoconstriction|response to drug|response to hormone stimulus|response to stress|smooth muscle contraction	integral to plasma membrane	alpha1-adrenergic receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(17)|ovary(1)|prostate(1)|skin(1)	36		all_cancers(63;0.122)|Ovarian(32;2.61e-05)|all_epithelial(46;0.118)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;4.92e-10)|Colorectal(74;0.0132)|READ - Rectum adenocarcinoma(644;0.115)	Alfuzosin(DB00346)|Amiodarone(DB01118)|Amphetamine(DB00182)|Benzphetamine(DB00865)|Bethanidine(DB00217)|Carvedilol(DB01136)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Dextroamphetamine(DB01576)|Doxazosin(DB00590)|Epinastine(DB00751)|Epinephrine(DB00668)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Labetalol(DB00598)|Lisdexamfetamine(DB01255)|Maprotiline(DB00934)|Mephentermine(DB01365)|Metaraminol(DB00610)|Methamphetamine(DB01577)|Methotrimeprazine(DB01403)|Methoxamine(DB00723)|Midodrine(DB00211)|Nefazodone(DB01149)|Nicergoline(DB00699)|Nilutamide(DB00665)|Norepinephrine(DB00368)|Norgestrel(DB00506)|Oxymetazoline(DB00935)|Perphenazine(DB00850)|Phendimetrazine(DB01579)|Phenoxybenzamine(DB00925)|Phenylephrine(DB00388)|Phenylpropanolamine(DB00397)|Prazosin(DB00457)|Promazine(DB00420)|Promethazine(DB01069)|Propericiazine(DB01608)|Propiomazine(DB00777)|Pseudoephedrine(DB00852)|Risperidone(DB00734)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)|Thioridazine(DB00679)|Tolazoline(DB00797)|Trazodone(DB00656)|Trifluoperazine(DB00831)|Ziprasidone(DB00246)	AGGGAAGAAAGACCCTGGAAG	0.368000													20	38					0	0	1	0	0
LRRIQ3	127255	broad.mit.edu	37	1	74492646	74492646	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:74492646C>T	ENST00000354431.4	-	8	1917	c.1726G>A	c.(1726-1728)Gaa>Aaa	p.E576K	LRRIQ3_ENST00000395089.1_Missense_Mutation_p.E576K	NM_001105659.1	NP_001099129.1	A6PVS8	LRIQ3_HUMAN	leucine-rich repeats and IQ motif containing 3	576										NS(2)|breast(1)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(13)|liver(1)|lung(27)|ovary(3)|prostate(1)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(5)	73						TTATATATTTCTTGAGATCTA	0.284000													10	12					0	0	1	0	0
NCAPH2	29781	broad.mit.edu	37	22	50957717	50957717	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:50957717C>T	ENST00000395701.3	+	9	923	c.829C>T	c.(829-831)Ctg>Ttg	p.L277L	NCAPH2_ENST00000299821.11_Silent_p.L277L|NCAPH2_ENST00000395698.3_Silent_p.L277L|NCAPH2_ENST00000420993.2_Silent_p.L277L			Q6IBW4	CNDH2_HUMAN	non-SMC condensin II complex, subunit H2	277					chromosome condensation	chromosome|nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(3)|lung(10)|ovary(1)|prostate(2)|skin(3)|stomach(1)	24		all_cancers(38;4.58e-14)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.212)		CAAGGCCGCTCTGGAGCCCAA	0.682000													5	3					0	0	1	0	0
DNAJC13	23317	broad.mit.edu	37	3	132229920	132229920	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:132229920G>A	ENST00000260818.6	+	44	5373	c.5125G>A	c.(5125-5127)Gca>Aca	p.A1709T		NM_015268.3	NP_056083.3	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	1709							heat shock protein binding			breast(4)|endometrium(2)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|urinary_tract(1)	34						GGTTCCAAAAGCATTTGCTGC	0.413000													51	92					0	0	1	0	0
NGF	4803	broad.mit.edu	37	1	115829272	115829272	+	Missense_Mutation	SNP	G	G	A	rs146716262		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:115829272G>A	ENST00000369512.2	-	3	313	c.145C>T	c.(145-147)Cgc>Tgc	p.R49C	RP4-663N10.1_ENST00000425449.1_RNA	NM_002506.2	NP_002497.2	P01138	NGF_HUMAN	nerve growth factor (beta polypeptide)	49					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding	p.R49C(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	13	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	CGGGCTCTGCGAAGGGCAGTG	0.612000													54	29					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129759863	129759863	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:129759863G>A	ENST00000421865.2	+	42	6090	c.6041G>A	c.(6040-6042)aGa>aAa	p.R2014K		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	2014	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GATCTCTTGAGAACTTTGAAT	0.363000													19	69					0	0	1	0	0
FGF5	2250	broad.mit.edu	37	4	81207815	81207815	+	Missense_Mutation	SNP	C	C	T	rs137903755		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:81207815C>T	ENST00000312465.7	+	3	1022	c.796C>T	c.(796-798)Cgc>Tgc	p.R266C	FGF5_ENST00000456523.3_3'UTR|FGF5_ENST00000503413.1_3'UTR	NM_004464.3	NP_004455.2	P12034	FGF5_HUMAN	fibroblast growth factor 5	266					cell proliferation|cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell division|positive regulation of cell proliferation	extracellular space	fibroblast growth factor receptor binding|growth factor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	22						ACTCAAGTTTCGCTTTGGATA	0.418000													38	21					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9525085	9525085	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:9525085C>T	ENST00000378429.3	-	9	2346	c.1800G>A	c.(1798-1800)agG>agA	p.R600R	PAK7_ENST00000353224.5_Silent_p.R600R|PAK7_ENST00000378423.1_Silent_p.R600R	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	600	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			CCAATGATTTCCTCTTCGGCA	0.453000													46	55					0	0	1	0	0
SDCBP2	27111	broad.mit.edu	37	20	1293297	1293297	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:1293297G>A	ENST00000360779.3	-	6	667	c.494C>T	c.(493-495)tCg>tTg	p.S165L	SDCBP2_ENST00000381808.3_Missense_Mutation_p.S80L|SDCBP2_ENST00000381812.1_Missense_Mutation_p.S165L|SDCBP2_ENST00000339987.3_Missense_Mutation_p.S165L	NM_080489.4	NP_536737.3	Q9H190	SDCB2_HUMAN	syndecan binding protein (syntenin) 2	165	PDZ 1.				intracellular signal transduction|intracellular transport|nervous system development	cytoplasm	protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity			endometrium(1)|large_intestine(3)|lung(1)|skin(1)|stomach(1)	7						GGCTTTGTGCGAGCTCCACCC	0.622000													38	25					0	0	1	0	0
CYP4F11	57834	broad.mit.edu	37	19	16032917	16032917	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:16032917C>T	ENST00000326742.7	-	8	1046	c.1045G>A	c.(1045-1047)Gaa>Aaa	p.E349K	CYP4F11_ENST00000402119.3_Missense_Mutation_p.E349K|CYP4F11_ENST00000248041.7_Missense_Mutation_p.E349K			Q9HBI6	CP4FB_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 11	349					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding	p.E349K(1)		NS(1)|breast(3)|endometrium(4)|large_intestine(2)|lung(11)|ovary(1)|skin(3)	25						TCCTGGTATTCTGGGTGCTTT	0.542000													30	37					0	0	1	0	0
ARSJ	79642	broad.mit.edu	37	4	114824237	114824237	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:114824237C>T	ENST00000315366.7	-	2	1859	c.993G>A	c.(991-993)caG>caA	p.Q331Q	ARSJ_ENST00000541197.1_Silent_p.Q331Q	NM_024590.3	NP_078866.3	Q5FYB0	ARSJ_HUMAN	arylsulfatase family, member J	331						extracellular region	arylsulfatase activity|metal ion binding			endometrium(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(3)|skin(2)|urinary_tract(1)	21		Ovarian(17;0.0035)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.00194)		CTGCCGTAGGCTGGCCACCAT	0.468000													12	66					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181724441	181724441	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:181724441C>T	ENST00000526775.1	+	27	4005	c.3840C>T	c.(3838-3840)ttC>ttT	p.F1280F	CACNA1E_ENST00000357570.5_Silent_p.F1250F|CACNA1E_ENST00000367573.2_Silent_p.F1299F|CACNA1E_ENST00000360108.3_Silent_p.F1280F|CACNA1E_ENST00000367567.4_Silent_p.F906F|CACNA1E_ENST00000358338.5_Silent_p.F1231F|CACNA1E_ENST00000367570.1_Silent_p.F1299F	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1299					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						ACAAGCTCTTCATGTTCATCT	0.473000													92	50					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123593705	123593705	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:123593705C>T	ENST00000340011.5	+	3	438	c.81C>T	c.(79-81)ttC>ttT	p.F27F	SPAM1_ENST00000439500.1_Silent_p.F27F|SPAM1_ENST00000402183.2_Silent_p.F27F|SPAM1_ENST00000223028.7_Silent_p.F27F|SPAM1_ENST00000460182.1_Silent_p.F27F	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	27					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	TTTTCACCTTCCTTCTGATTC	0.408000													8	25					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55874916	55874916	+	Silent	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:55874916G>T	ENST00000388975.3	-	8	969	c.853C>A	c.(853-855)Cga>Aga	p.R285R		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	285					cell cycle|cell division	septin complex	GTP binding|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			AGCATATCTCGGAGCTTAACG	0.338000													21	42					1.10513e-12	1.11637e-12	1	1	0
CEP250	11190	broad.mit.edu	37	20	34091457	34091457	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:34091457C>T	ENST00000397527.1	+	30	5980	c.5260C>T	c.(5260-5262)Cag>Tag	p.Q1754*	CEP250_ENST00000342580.4_Nonsense_Mutation_p.Q1698*	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	1754	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GCTCAAAGACCAGCTGGAGCA	0.577000													48	103					0	0	1	0	0
C9orf153	389766	broad.mit.edu	37	9	88842279	88842279	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:88842279C>T	ENST00000376001.3	-	4	355	c.275G>A	c.(274-276)aGa>aAa	p.R92K	C9orf153_ENST00000469914.1_Intron|C9orf153_ENST00000339137.3_Intron	NM_001276366.1	NP_001263295.1	Q5TBE3	CI153_HUMAN	chromosome 9 open reading frame 153	92										breast(1)|lung(1)	2						tggggtctttctatgttttcc	0.348000													19	7					0	0	1	0	0
SERPIND1	3053	broad.mit.edu	37	22	21141180	21141180	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:21141180G>A	ENST00000215727.5	+	5	1609	c.1326G>A	c.(1324-1326)acG>acA	p.T442T	PI4KA_ENST00000255882.6_Intron|PI4KA_ENST00000466162.1_Intron|SERPIND1_ENST00000406799.1_Silent_p.T442T|PI4KA_ENST00000572273.1_Intron	NM_000185.3	NP_000176.2	P05546	HEP2_HUMAN	serpin peptidase inhibitor, clade D (heparin cofactor), member 1	442			T -> M (in dbSNP:rs5904).		blood coagulation|chemotaxis|regulation of proteolysis	extracellular region	heparin binding|serine-type endopeptidase inhibitor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	13	all_cancers(11;6.16e-25)|all_epithelial(7;1.02e-22)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000536)|Lung(15;0.0108)|Epithelial(17;0.196)		Ardeparin(DB00407)	ACCAAGGCACGATCACAGTGA	0.547000													48	55					0	0	1	0	0
ITGA7	3679	broad.mit.edu	37	12	56094848	56094848	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:56094848C>T	ENST00000257880.7	-	4	724	c.505G>A	c.(505-507)Gac>Aac	p.D169N	ITGA7_ENST00000452168.2_Missense_Mutation_p.D72N|ITGA7_ENST00000347027.6_Missense_Mutation_p.D169N|ITGA7_ENST00000257879.6_Missense_Mutation_p.D169N|ITGA7_ENST00000553804.1_Missense_Mutation_p.D169N|ITGA7_ENST00000394229.2_Missense_Mutation_p.D169N|ITGA7_ENST00000555728.1_Missense_Mutation_p.D169N|ITGA7_ENST00000394230.2_Missense_Mutation_p.D169N			Q13683	ITA7_HUMAN	integrin, alpha 7	169					cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(16)|ovary(2)|prostate(2)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						ATGGCCAGGTCCTGGCTGAGC	0.597000													19	25					0	0	1	0	0
GBP7	388646	broad.mit.edu	37	1	89599058	89599058	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:89599058C>T	ENST00000294671.2	-	10	1683	c.1545G>A	c.(1543-1545)atG>atA	p.M515I		NM_207398.2	NP_997281.2	Q8N8V2	GBP7_HUMAN	guanylate binding protein 7	515						integral to membrane	GTP binding|GTPase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Lung NSC(277;0.0908)		all cancers(265;0.00835)|Epithelial(280;0.0322)		GAGCCTCCATCATTTGCTGCT	0.443000													70	66					0	0	1	0	0
TNFRSF11B	4982	broad.mit.edu	37	8	119938927	119938927	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:119938927C>T	ENST00000297350.4	-	4	1001	c.623G>A	c.(622-624)aGg>aAg	p.R208K		NM_002546.3	NP_002537.3	O00300	TR11B_HUMAN	tumor necrosis factor receptor superfamily, member 11b	208	Death 1.				apoptosis|skeletal system development		cytokine activity|receptor activity			breast(1)|central_nervous_system(3)|endometrium(4)|large_intestine(6)|lung(7)|prostate(3)|skin(1)	25	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			AACAGCAAACCTGAAGAATGC	0.398000													11	22					0	0	1	0	0
CCDC69	26112	broad.mit.edu	37	5	150563997	150563997	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:150563997C>T	ENST00000355417.2	-	8	795	c.621G>A	c.(619-621)gaG>gaA	p.E207E	CCDC69_ENST00000521308.1_5'UTR	NM_015621.2	NP_056436.2	A6NI79	CCD69_HUMAN	coiled-coil domain containing 69	207										haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(2)|stomach(1)	9		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCAGATTTTTCTCTTTCTATA	0.473000													12	13					0	0	1	0	0
RNF133	168433	broad.mit.edu	37	7	122338703	122338703	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:122338703G>A	ENST00000340112.2	-	1	507	c.270C>T	c.(268-270)acC>acT	p.T90T	CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000412584.2_Intron|CADPS2_ENST00000313070.7_Intron|CADPS2_ENST00000449022.2_Intron	NM_139175.1	NP_631914.1	Q8WVZ7	RN133_HUMAN	ring finger protein 133	90	PA.					endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21						GGCTGAAAATGGTATTGGGAT	0.453000													51	87					0	0	1	0	0
ZPLD1	131368	broad.mit.edu	37	3	102171970	102171970	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:102171970G>A	ENST00000306176.1	+	3	462	c.362G>A	c.(361-363)gGa>gAa	p.G121E	ZPLD1_ENST00000491959.1_Missense_Mutation_p.G105E|ZPLD1_ENST00000466937.1_Missense_Mutation_p.G105E	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	105	ZP.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						GAGGGCTGTGGAAACAACCTG	0.443000													11	22					0	0	1	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3672567	3672567	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:3672567C>T	ENST00000344754.4	-	16	4312	c.4313G>A	c.(4312-4314)gGg>gAg	p.G1438E	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.G1438E	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	1438	Ig-like C2-type 14.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CTGCAACCGCCCGATGGTGCT	0.597000													31	31					0	0	1	0	0
DPYD	1806	broad.mit.edu	37	1	97771853	97771853	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:97771853C>T	ENST00000370192.3	-	17	2159	c.2058_splice	c.e17-1	p.D687_splice	DPYD-AS1_ENST00000422980.1_RNA	NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	687					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AGCTCTGGATCCTGTTCAAAT	0.428000													94	49					0	0	1	0	0
OR1L8	138881	broad.mit.edu	37	9	125330206	125330206	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:125330206G>A	ENST00000304865.2	-	1	632	c.551C>T	c.(550-552)cCt>cTt	p.P184L		NM_001004454.1	NP_001004454.1	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L, member 8	184					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						TTTCAGCACAGGGCTGAGGTC	0.453000													14	13					0	0	1	0	0
COL19A1	1310	broad.mit.edu	37	6	70639521	70639521	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:70639521G>A	ENST00000322773.4	+	6	697	c.595G>A	c.(595-597)Gaa>Aaa	p.E199K		NM_001858.4	NP_001849.2	Q14993	COJA1_HUMAN	collagen, type XIX, alpha 1	199	TSP N-terminal.				cell differentiation|cell-cell adhesion|extracellular matrix organization|skeletal system development	collagen	extracellular matrix structural constituent|protein binding, bridging			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(8)|lung(54)|ovary(3)|prostate(2)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	109						GCAGACTGATGAAAAGGACAC	0.418000													41	40					0	0	1	0	0
CALCOCO2	10241	broad.mit.edu	37	17	46925443	46925443	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:46925443C>T	ENST00000258947.3	+	3	299	c.198C>T	c.(196-198)acC>acT	p.T66T	CALCOCO2_ENST00000509507.1_Silent_p.T87T|CALCOCO2_ENST00000508679.1_5'UTR|CALCOCO2_ENST00000448105.2_Silent_p.T90T|CALCOCO2_ENST00000416445.2_Silent_p.T66T	NM_001261390.1|NM_001261391.1|NM_001261393.1|NM_001261395.1|NM_005831.4	NP_001248319.1|NP_001248320.1|NP_001248322.1|NP_001248324.1|NP_005822.1	Q13137	CACO2_HUMAN	calcium binding and coiled-coil domain 2	66					response to interferon-gamma|viral reproduction	cytoskeleton|Golgi apparatus|nucleus|perinuclear region of cytoplasm|soluble fraction	protein homodimerization activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|stomach(1)|urinary_tract(1)	15						GGAAGACAACCCGTGAGTATT	0.413000													17	20					0	0	1	0	0
LAMP5	24141	broad.mit.edu	37	20	9496652	9496652	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:9496652C>T	ENST00000246070.2	+	3	735	c.243C>T	c.(241-243)atC>atT	p.I81I	LAMP5_ENST00000427562.2_Intron	NM_012261.3	NP_036393.1	Q9UJQ1	CT103_HUMAN	lysosomal-associated membrane protein family, member 5	81			I -> V (in dbSNP:rs2232263).			integral to membrane											CCCAGCTGATCACAGAACAGG	0.672000													7	20					0	0	1	0	0
TRIM35	23087	broad.mit.edu	37	8	27145286	27145286	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:27145286G>A	ENST00000305364.4	-	6	1346	c.1263C>T	c.(1261-1263)gtC>gtT	p.V421V	TRIM35_ENST00000521253.1_3'UTR	NM_171982.3	NP_741983.2	Q9UPQ4	TRI35_HUMAN	tripartite motif containing 35	421	B30.2/SPRY.				apoptosis|induction of apoptosis|negative regulation of mitotic cell cycle	cytoplasm|nucleus	zinc ion binding			breast(1)|endometrium(6)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	14		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0213)|Epithelial(17;9.34e-10)|Colorectal(74;0.141)		GGATGGCCAGGACCAGGGGCG	0.672000													15	18					0	0	1	0	0
ANKS6	203286	broad.mit.edu	37	9	101546353	101546353	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:101546353G>C	ENST00000353234.4	-	4	1041	c.994C>G	c.(994-996)Cta>Gta	p.L332V	ANKS6_ENST00000375019.2_Missense_Mutation_p.L31V|ANKS6_ENST00000540940.1_Missense_Mutation_p.L137V|ANKS6_ENST00000375018.1_Missense_Mutation_p.L332V			Q68DC2	ANKS6_HUMAN	ankyrin repeat and sterile alpha motif domain containing 6	332										endometrium(3)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	21		Acute lymphoblastic leukemia(62;0.0527)				ACAGCTGCTAGCATCAGTGGC	0.597000													38	10					0	0	1	0	0
EDIL3	10085	broad.mit.edu	37	5	83360566	83360566	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:83360566C>T	ENST00000296591.5	-	8	1323	c.905G>A	c.(904-906)cGa>cAa	p.R302Q	EDIL3_ENST00000380138.3_Missense_Mutation_p.R292Q|EDIL3_ENST00000510271.1_5'UTR	NM_005711.3	NP_005702.3	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like domains 3	302	F5/8 type C 1.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding	p.R302Q(1)		cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|prostate(5)|skin(3)	31		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		GCAATGTCTTCGACAAACTTG	0.383000													14	35					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9061149	9061149	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:9061149G>A	ENST00000397910.4	-	3	26500	c.26297C>T	c.(26296-26298)tCc>tTc	p.S8766F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8768	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTTTCCGTGGAGATTTCTGG	0.507000													32	57					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13883114	13883114	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:13883114G>A	ENST00000265104.4	-	20	3177	c.3073C>T	c.(3073-3075)Cct>Tct	p.P1025S	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1025	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TCCAGGGCAGGGGCCATGACG	0.527000									Kartagener syndrome				32	23					0	0	1	0	0
TSHZ2	128553	broad.mit.edu	37	20	51871684	51871684	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:51871684C>T	ENST00000371497.5	+	2	2574	c.1687C>T	c.(1687-1689)Cag>Tag	p.Q563*	TSHZ2_ENST00000603338.2_Nonsense_Mutation_p.Q560*|TSHZ2_ENST00000329613.6_Nonsense_Mutation_p.Q560*	NM_001193421.1|NM_173485.5	NP_001180350.1|NP_775756.3	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	563				Q -> R (in Ref. 1; BAC03610).	multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(16)|lung(38)|ovary(5)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	84			STAD - Stomach adenocarcinoma(23;0.1)			TATGGGATCCCAGGTACTGCA	0.597000													38	95					0	0	1	0	0
XKR6	286046	broad.mit.edu	37	8	11058468	11058468	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:11058468G>A	ENST00000416569.2	-	1	407	c.381C>T	c.(379-381)ctC>ctT	p.L127L	XKR6_ENST00000297303.4_Silent_p.L127L	NM_173683.3	NP_775954.2	Q5GH73	XKR6_HUMAN	XK, Kell blood group complex subunit-related family, member 6	127						integral to membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(8)|ovary(2)|prostate(1)|skin(3)	31				Lung(29;0.0407)|COAD - Colon adenocarcinoma(149;0.0555)		ACAGGCAGTCGAGCCACGGCC	0.761000													13	61					0	0	1	0	0
ACOT11	26027	broad.mit.edu	37	1	55072900	55072900	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:55072900C>T	ENST00000371316.3	+	14	1546	c.1464C>T	c.(1462-1464)ttC>ttT	p.F488F	ACOT11_ENST00000481208.1_3'UTR|ACOT11_ENST00000343744.2_Silent_p.F488F	NM_015547.3	NP_056362.1	Q8WXI4	ACO11_HUMAN	acyl-CoA thioesterase 11	488	START.				fatty acid metabolic process|intracellular signal transduction|response to cold		acyl-CoA thioesterase activity|carboxylesterase activity			NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(3)|lung(5)|ovary(1)	17						CCCAGGACTTCGTGATCCTGG	0.627000													57	28					0	0	1	0	0
ALDH1L1	10840	broad.mit.edu	37	3	125876190	125876190	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:125876190C>T	ENST00000393434.2	-	4	873	c.524G>A	c.(523-525)gGg>gAg	p.G175E	ALDH1L1_ENST00000455064.2_5'UTR|ALDH1L1_ENST00000273450.3_Missense_Mutation_p.G185E|ALDH1L1_ENST00000452905.2_Intron|ALDH1L1_ENST00000393431.2_Missense_Mutation_p.G175E|ALDH1L1_ENST00000472186.1_Missense_Mutation_p.G175E	NM_012190.3	NP_036322.2	O75891	AL1L1_HUMAN	aldehyde dehydrogenase 1 family, member L1	175	GART.				10-formyltetrahydrofolate catabolic process|biosynthetic process		acyl carrier activity|cofactor binding|formyltetrahydrofolate dehydrogenase activity|hydroxymethyl-, formyl- and related transferase activity|methyltransferase activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(5)|large_intestine(10)|lung(22)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	52				GBM - Glioblastoma multiforme(114;0.0462)	Tetrahydrofolic acid(DB00116)	CCTCACCATCCCTTTGATGCC	0.657000													48	69					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152381774	152381774	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:152381774T>A	ENST00000397345.3	-	151	22377	c.22175A>T	c.(22174-22176)aAg>aTg	p.K7392M	NEB_ENST00000603639.1_Missense_Mutation_p.K7392M|NEB_ENST00000604864.1_Missense_Mutation_p.K7392M|NEB_ENST00000409198.1_Missense_Mutation_p.K5691M|NEB_ENST00000172853.10_Missense_Mutation_p.K5691M|NEB_ENST00000427231.2_Missense_Mutation_p.K7392M	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	5691					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		GACAAACTTCTTTTTGTAATT	0.398000													15	20					0	0	1	0	0
C4A	720	broad.mit.edu	37	6	31963866	31963866	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:31963866C>T	ENST00000428956.2	+	26	3449	c.3365C>T	c.(3364-3366)cCa>cTa	p.P1122L	C4A_ENST00000498271.1_Missense_Mutation_p.P1122L	NM_007293.2	NP_009224.2			complement component 4A (Rodgers blood group)																		GACCCCTGTCCAGTGTTAGAC	0.622000													31	137					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41048463	41048463	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:41048463C>T	ENST00000399564.4	-	16	2097	c.1647G>A	c.(1645-1647)tgG>tgA	p.W549*	MROH2B_ENST00000506092.2_Nonsense_Mutation_p.W104*	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		AACGTGTTTTCCATAGGTCTA	0.478000													28	63					0	0	1	0	0
TAS2R10	50839	broad.mit.edu	37	12	10978126	10978126	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:10978126G>A	ENST00000240619.2	-	1	831	c.743C>T	c.(742-744)tCa>tTa	p.S248L		NM_023921.1	NP_076410.1	Q9NYW0	T2R10_HUMAN	taste receptor, type 2, member 10	248					sensory perception of taste	integral to membrane	taste receptor activity			breast(1)|central_nervous_system(1)|large_intestine(7)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	17						AGTAAAACATGATATTTCTAT	0.378000													31	27					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127789803	127789803	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:127789803C>T	ENST00000368679.4	-	9	1067	c.758G>A	c.(757-759)aGa>aAa	p.R253K	ADAM12_ENST00000368676.4_Missense_Mutation_p.R253K	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	253	Peptidase M12B.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		GTTCAGTGGTCTGTAAAACTG	0.428000													15	6					0	0	1	0	0
C1orf61	10485	broad.mit.edu	37	1	156374372	156374372	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:156374372G>A	ENST00000368243.1	-	7	561	c.445C>T	c.(445-447)Cat>Tat	p.H149Y		NM_006365.1	NP_006356.1	Q13536	CROC4_HUMAN	chromosome 1 open reading frame 61	149						nucleus				large_intestine(2)|lung(2)|skin(1)	5	Hepatocellular(266;0.158)					CCAACCAGATGAAGTACATTC	0.423000													5	59					0	0	1	0	0
FAM161A	84140	broad.mit.edu	37	2	62065718	62065718	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:62065718T>A	ENST00000404929.1	-	4	1717	c.1706A>T	c.(1705-1707)cAt>cTt	p.H569L	FAM161A_ENST00000405894.3_Intron	NM_001201543.1	NP_001188472.1	Q3B820	F161A_HUMAN	family with sequence similarity 161, member A	540					response to stimulus|visual perception	centrosome				breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TAAACTTTGATGTGAGTCATA	0.363000													39	20					0	0	1	0	0
FBXO30	84085	broad.mit.edu	37	6	146126700	146126700	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:146126700G>T	ENST00000237281.4	-	2	1008	c.842C>A	c.(841-843)tCt>tAt	p.S281Y		NM_032145.4	NP_115521.3	Q8TB52	FBX30_HUMAN	F-box protein 30	281							ubiquitin-protein ligase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26		Ovarian(120;0.0776)		OV - Ovarian serous cystadenocarcinoma(155;1.95e-07)|GBM - Glioblastoma multiforme(68;0.0149)		ACAAAGAGCAGAAGTGTCATA	0.343000													19	148					3.32936e-07	3.34399e-07	1	1	0
RIOK3	8780	broad.mit.edu	37	18	21053520	21053520	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:21053520C>T	ENST00000339486.3	+	8	1560	c.943C>T	c.(943-945)Cgc>Tgc	p.R315C	RIOK3_ENST00000581585.1_Missense_Mutation_p.R299C|RIOK3_ENST00000577501.1_Missense_Mutation_p.R315C	NM_003831.3	NP_003822.2	O14730	RIOK3_HUMAN	RIO kinase 3	315	Protein kinase.				chromosome segregation		ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(3)|ovary(2)	10	all_cancers(21;0.000106)|all_epithelial(16;6.74e-07)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0202)|Ovarian(20;0.127)					GTTTAAAGATCGCTTCAGTAA	0.338000													10	20					0	0	1	0	0
PDE1A	5136	broad.mit.edu	37	2	183066221	183066221	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:183066221G>A	ENST00000435564.1	-	10	1318	c.1118C>T	c.(1117-1119)tCc>tTc	p.S373F	PDE1A_ENST00000346717.4_Missense_Mutation_p.S339F|PDE1A_ENST00000331935.6_Missense_Mutation_p.S373F|PDE1A_ENST00000358139.2_Missense_Mutation_p.S373F|PDE1A_ENST00000410103.1_Missense_Mutation_p.S373F|PDE1A_ENST00000536095.1_Missense_Mutation_p.S269F|PDE1A_ENST00000351439.5_Missense_Mutation_p.S357F|PDE1A_ENST00000409365.1_Missense_Mutation_p.S357F|PDE1A_ENST00000456212.1_Missense_Mutation_p.S373F	NM_001258312.1|NM_005019.4	NP_001245241.1|NP_005010.2	P54750	PDE1A_HUMAN	phosphodiesterase 1A, calmodulin-dependent	373	Catalytic (By similarity).				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|platelet activation	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(5)|large_intestine(3)|lung(12)|ovary(1)|pancreas(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(2)	35			OV - Ovarian serous cystadenocarcinoma(117;0.061)			CAGCTTCCAGGATTTGGCTGG	0.463000													45	48					0	0	1	0	0
DRD2	1813	broad.mit.edu	37	11	113286151	113286151	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:113286151G>A	ENST00000362072.3	-	5	1059	c.715C>T	c.(715-717)Cca>Tca	p.P239S	DRD2_ENST00000355319.2_Missense_Mutation_p.P239S|DRD2_ENST00000542968.1_Missense_Mutation_p.P239S|DRD2_ENST00000544518.1_Missense_Mutation_p.P238S|DRD2_ENST00000538967.1_Missense_Mutation_p.P239S|DRD2_ENST00000346454.3_Missense_Mutation_p.P239S|DRD2_ENST00000535984.1_5'UTR	NM_000795.3	NP_000786.1	P14416	DRD2_HUMAN	dopamine receptor D2	239	Interaction with PPP1R9B (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(18)|pancreas(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	39		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	ACCTTTAGTGGAGCCCTCAGG	0.572000													54	88					0	0	1	0	0
TCEAL2	140597	broad.mit.edu	37	X	101382460	101382460	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:101382460G>A	ENST00000372780.1	+	3	877	c.658G>A	c.(658-660)Gac>Aac	p.D220N	TCEAL2_ENST00000329035.2_Missense_Mutation_p.D220N	NM_080390.3	NP_525129.1	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	220					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)	11						CCCACGAAGGGACACTGAAGA	0.488000													60	16					0	0	1	0	0
IGDCC4	57722	broad.mit.edu	37	15	65680892	65680892	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:65680892C>T	ENST00000352385.2	-	16	2949	c.2740G>A	c.(2740-2742)Gag>Aag	p.E914K		NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	914	Fibronectin type-III 5.					integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						GTGTCGCTCTCCAGGCCATGG	0.627000													25	76					0	0	1	0	0
DGAT2	84649	broad.mit.edu	37	11	75501756	75501756	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:75501756C>T	ENST00000228027.7	+	4	669	c.409C>T	c.(409-411)Cga>Tga	p.R137*	DGAT2_ENST00000376262.3_Nonsense_Mutation_p.R94*	NM_032564.4	NP_115953.2	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	137					glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity	p.R137*(1)		endometrium(3)|large_intestine(5)|lung(5)|prostate(2)|skin(2)	17	Ovarian(111;0.103)					GCGCTACTTTCGAGACTACTT	0.537000													35	58					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100675720	100675720	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:100675720C>T	ENST00000306151.4	+	3	1087	c.1023C>T	c.(1021-1023)gcC>gcT	p.A341A		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	341	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					GTACGCCTGCCAGCACCATGC	0.483000													158	230					0	0	1	0	0
APCS	325	broad.mit.edu	37	1	159558228	159558228	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:159558228G>A	ENST00000255040.2	+	2	499	c.402G>A	c.(400-402)gtG>gtA	p.V134V		NM_001639.3	NP_001630.1	P02743	SAMP_HUMAN	amyloid P component, serum	134	Pentaxin.				acute-phase response|chaperone-mediated protein complex assembly|protein folding	extracellular space	metal ion binding|sugar binding|unfolded protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|skin(2)	20	all_hematologic(112;0.0429)					CACCTTTGGTGAAAAAGGGTC	0.498000													43	22					0	0	1	0	0
HSD17B13	345275	broad.mit.edu	37	4	88239495	88239495	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:88239495G>A	ENST00000328546.4	-	2	368	c.304C>T	c.(304-306)Cgc>Tgc	p.R102C	RP11-529H2.2_ENST00000508163.1_RNA|HSD17B13_ENST00000302219.6_Intron	NM_178135.3	NP_835236.2	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	102						extracellular region	binding|oxidoreductase activity			endometrium(1)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	8		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		TTTAGAGAGCGATAGATCTCT	0.468000													17	58					0	0	1	0	0
TDRD9	122402	broad.mit.edu	37	14	104473036	104473036	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:104473036G>A	ENST00000409874.4	+	17	1981	c.1933G>A	c.(1933-1935)Gat>Aat	p.D645N	TDRD9_ENST00000339063.5_Missense_Mutation_p.D645N	NM_153046.2	NP_694591.2	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	645					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				GCAGCATCTCGATGGATATAG	0.338000													14	3					0	0	1	0	0
PAPOLG	64895	broad.mit.edu	37	2	61009027	61009027	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:61009027C>T	ENST00000238714.3	+	11	1163	c.914C>T	c.(913-915)cCa>cTa	p.P305L	PAPOLG_ENST00000483370.1_3'UTR	NM_022894.3	NP_075045.2	Q9BWT3	PAPOG_HUMAN	poly(A) polymerase gamma	305					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(11)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	35	all_hematologic(2;0.0797)		LUSC - Lung squamous cell carcinoma(5;1.19e-07)|Lung(5;2.86e-06)|Epithelial(17;0.0768)			CAGGTAAATCCATCAGATAGG	0.368000													16	64					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43484894	43484894	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:43484894A>C	ENST00000395891.1	+	11	2728	c.2123A>C	c.(2122-2124)tAc>tCc	p.Y708S	HECW1_ENST00000453890.1_Missense_Mutation_p.Y708S	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	708					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CCCTCCTGCTACAACGGCAAC	0.637000													36	63					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49457098	49457098	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:49457098C>T	ENST00000374201.3	-	3	577	c.275G>A	c.(274-276)gGa>gAa	p.G92E	FRMPD2_ENST00000305531.3_Missense_Mutation_p.G90E|FRMPD2_ENST00000407470.4_Missense_Mutation_p.G83E	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	92	KIND.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		CTCACTCTGTCCCTGTAGCAG	0.562000													8	8					0	0	1	0	0
MRVI1	10335	broad.mit.edu	37	11	10622562	10622562	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:10622562C>T	ENST00000547195.1	-	14	2147	c.1647G>A	c.(1645-1647)gtG>gtA	p.V549V	MRVI1_ENST00000545852.1_Silent_p.V325V|MRVI1_ENST00000552103.1_Silent_p.V549V|LYVE1_ENST00000531706.1_Intron|MRVI1_ENST00000424001.1_Silent_p.V325V|MRVI1_ENST00000423302.2_Silent_p.V640V|MRVI1_ENST00000531107.1_Silent_p.V632V|MRVI1_ENST00000527509.2_Silent_p.V549V|MRVI1_ENST00000436272.1_Silent_p.V613V|MRVI1_ENST00000534266.2_Silent_p.V325V|MRVI1_ENST00000541483.1_Silent_p.V434V|MRVI1_ENST00000421747.1_Silent_p.V631V|MRVI1_ENST00000558540.1_Silent_p.V325V	NM_001100163.2|NM_001206881.1	NP_001093633.1|NP_001193810.1	Q9Y6F6	MRVI1_HUMAN	murine retrovirus integration site 1 homolog	613	Interaction with ITPR1 (By similarity).				platelet activation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum				central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)	22				all cancers(16;2.68e-07)|Epithelial(150;3.04e-07)|BRCA - Breast invasive adenocarcinoma(625;0.0723)		TTAGATTCTCCACATACTGCA	0.517000													71	162					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179474445	179474445	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179474445C>T	ENST00000589042.1	-	272	51929	c.51705G>A	c.(51703-51705)cgG>cgA	p.R17235R	TTN_ENST00000342992.6_Silent_p.R14667R|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Silent_p.R15594R|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.R8170R|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000342175.6_Silent_p.R8362R|TTN_ENST00000359218.5_Silent_p.R8295R|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15594	Fibronectin type-III 24.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAGGAGTAGCCCGAGAAGGTT	0.438000													73	108					0	0	1	0	0
SCRN1	9805	broad.mit.edu	37	7	29980343	29980343	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:29980343G>A	ENST00000426154.1	-	5	870	c.694C>T	c.(694-696)Cat>Tat	p.H232Y	SCRN1_ENST00000409497.1_Missense_Mutation_p.H232Y|SCRN1_ENST00000416113.2_Intron|SCRN1_ENST00000242059.5_Missense_Mutation_p.H232Y	NM_001145513.1	NP_001138985.1	Q12765	SCRN1_HUMAN	secernin 1	232					exocytosis|proteolysis	cytoplasm|nuclear membrane	dipeptidase activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(1)|lung(12)|ovary(2)|prostate(2)|skin(2)	25						CAGTCTAGATGATCCTCAACT	0.498000													33	67					0	0	1	0	0
PDZD2	23037	broad.mit.edu	37	5	32074441	32074441	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:32074441G>A	ENST00000438447.1	+	18	3617	c.3229G>A	c.(3229-3231)Gaa>Aaa	p.E1077K	PDZD2_ENST00000282493.3_Missense_Mutation_p.E1077K			O15018	PDZD2_HUMAN	PDZ domain containing 2	1077					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						GTGGAAGAAGGAACTGTCAGG	0.587000													60	60					0	0	1	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21054378	21054378	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:21054378G>A	ENST00000381545.3	+	15	2061	c.1842G>A	c.(1840-1842)agG>agA	p.R614R	SLCO1B3_ENST00000553473.1_Silent_p.R614R|SLCO1B3_ENST00000261196.2_Silent_p.R614R|LST3_ENST00000540229.1_Silent_p.R614R|LST3_ENST00000381541.3_Intron|SLCO1B7_ENST00000554957.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	614					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					GGGCTTGTAGGATATATAATT	0.348000													14	34					0	0	1	0	0
HIC2	23119	broad.mit.edu	37	22	21799618	21799618	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:21799618C>T	ENST00000443632.2	+	2	806	c.434C>T	c.(433-435)cCc>cTc	p.P145L	HIC2_ENST00000407464.2_Missense_Mutation_p.P145L|HIC2_ENST00000407598.2_Missense_Mutation_p.P145L			Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	145					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				GCCGGCAAGCCCTTTGGCTCT	0.697000													16	15					0	0	1	0	0
CEACAM4	1089	broad.mit.edu	37	19	42125769	42125769	+	Splice_Site	SNP	C	C	T	rs1126455		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:42125769C>T	ENST00000221954.2	-	7	780		c.e7-1			NM_001817.2	NP_001808.2	O75871	CEAM4_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 4							integral to plasma membrane|membrane fraction				NS(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(3)|skin(3)|urinary_tract(1)	16						ATAGCAATTCCTGTAAAAACA	0.522000													31	51					0	0	1	0	0
GIMAP5	55340	broad.mit.edu	37	7	150439925	150439925	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:150439925C>T	ENST00000358647.3	+	3	1065	c.698C>T	c.(697-699)aCt>aTt	p.T233I	GIMAP5_ENST00000479556.1_3'UTR	NM_018384.4	NP_060854.2			GTPase, IMAP family member 5											central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|urinary_tract(2)	19			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CTCCAAAGAACTGGAGCTGGG	0.582000													23	41					0	0	1	0	0
DOCK8	81704	broad.mit.edu	37	9	406981	406981	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:406981G>A	ENST00000432829.2	+	28	3554	c.3238G>A	c.(3238-3240)Gat>Aat	p.D1080N	DOCK8_ENST00000469391.1_Missense_Mutation_p.D1048N|DOCK8_ENST00000382329.1_Missense_Mutation_p.D615N|DOCK8_ENST00000453981.1_Missense_Mutation_p.D1148N	NM_203447.3	NP_982272.2	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	1148					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity	p.D1148N(1)|p.D1080N(1)		breast(1)|central_nervous_system(5)|endometrium(2)|kidney(6)|large_intestine(13)|lung(22)|ovary(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	65		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		CAGCATGTTCGATCTGACTTC	0.537000													47	20					0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113321160	113321160	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:113321160C>T	ENST00000389385.4	+	16	1886	c.1389C>T	c.(1387-1389)ctC>ctT	p.L463L	RPH3A_ENST00000420983.2_Silent_p.L463L|RPH3A_ENST00000548866.1_Silent_p.L414L|RPH3A_ENST00000415485.3_Silent_p.L463L|RPH3A_ENST00000543106.2_Silent_p.L463L|RPH3A_ENST00000447659.2_Silent_p.L414L|RPH3A_ENST00000551052.1_Silent_p.L459L|RPH3A_ENST00000549913.2_3'UTR	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	463	C2 1.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		ATGAGACCCTCGTGTATCACG	0.567000													10	24					0	0	1	0	0
LARS	51520	broad.mit.edu	37	5	145537167	145537167	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:145537167G>C	ENST00000394434.2	-	10	1030	c.864C>G	c.(862-864)ttC>ttG	p.F288L	LARS_ENST00000511505.1_5'UTR|LARS_ENST00000274562.9_Missense_Mutation_p.F261L|LARS_ENST00000545646.1_Missense_Mutation_p.F242L|LARS_ENST00000510191.1_Missense_Mutation_p.F234L	NM_020117.9	NP_064502.9	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	288	Editing domain.				leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding	p.F288F(1)		breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	CAGCCACCAAGAAAATATTTT	0.378000													16	10					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10429959	10429959	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:10429959C>T	ENST00000245503.5	-	30	4528	c.4144G>A	c.(4144-4146)Gag>Aag	p.E1382K	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000397183.2_Missense_Mutation_p.E1382K|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Intron	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1382					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GCGTCCGTCTCGTATTTGGTC	0.532000													65	35					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124311429	124311429	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:124311429G>A	ENST00000409039.3	+	24	4046	c.4021G>A	c.(4021-4023)Gag>Aag	p.E1341K		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1341	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTTGAAAAACGAGGCACTAAG	0.428000													26	26					0	0	1	0	0
PPAP2B	8613	broad.mit.edu	37	1	56962269	56962269	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:56962269G>A	ENST00000371250.3	-	6	1441	c.890C>T	c.(889-891)tCa>tTa	p.S297L	PPAP2B_ENST00000459962.1_5'UTR	NM_003713.4	NP_003704.3	O14495	LPP3_HUMAN	phosphatidic acid phosphatase type 2B	297					canonical Wnt receptor signaling pathway involved in positive regulation of cell-cell adhesion|canonical Wnt receptor signaling pathway involved in positive regulation of endothelial cell migration|canonical Wnt receptor signaling pathway involved in positive regulation of wound healing|germ cell migration|homotypic cell-cell adhesion|negative regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|sphingolipid metabolic process	adherens junction|Golgi apparatus|integral to membrane	phosphatidate phosphatase activity|phosphoprotein phosphatase activity|protein binding|sphingosine-1-phosphate phosphatase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						GTCCACAGGTGAAAGGATTTC	0.473000													19	81					0	0	1	0	0
CCDC129	223075	broad.mit.edu	37	7	31592661	31592661	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:31592661G>A	ENST00000319386.3	+	2	1016	c.23G>A	c.(22-24)gGa>gAa	p.G8E	CCDC129_ENST00000407970.3_Missense_Mutation_p.G8E|CCDC129_ENST00000451887.2_Missense_Mutation_p.G34E|CCDC129_ENST00000482748.1_Intron			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	8										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						AAATCACAAGGATCTGACAAC	0.488000													5	7					0	0	1	0	0
MYL1	4632	broad.mit.edu	37	2	211163277	211163277	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:211163277C>T	ENST00000352451.3	-	3	318	c.171G>A	c.(169-171)gaG>gaA	p.E57E	MYL1_ENST00000496436.1_5'UTR|MYL1_ENST00000341685.4_Silent_p.E13E	NM_079420.2	NP_524144.1	P05976	MYL1_HUMAN	myosin, light chain 1, alkali; skeletal, fast	57	EF-hand 1.				muscle filament sliding|muscle organ development	cytosol|muscle myosin complex|sarcomere	calcium ion binding|structural constituent of muscle			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)	16				Epithelial(149;0.00573)|Lung(261;0.0422)|LUSC - Lung squamous cell carcinoma(261;0.0444)|all cancers(144;0.057)		GGAGAAATGCCTCCTTGAATT	0.418000													9	35					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10355552	10355552	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:10355552C>T	ENST00000255381.2	-	27	3554	c.3444G>A	c.(3442-3444)gaG>gaA	p.E1148E	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1148					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						CACTGATCTCCTCCAGCTCCC	0.617000													67	29					0	0	1	0	0
ACSS3	79611	broad.mit.edu	37	12	81613796	81613796	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:81613796G>A	ENST00000548058.1	+	11	2365	c.1455G>A	c.(1453-1455)atG>atA	p.M485I	ACSS3_ENST00000261206.3_Missense_Mutation_p.M484I|ACSS3_ENST00000548324.1_Missense_Mutation_p.M167I			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	485						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						TTGTAGTTATGATTTTGGATG	0.254000													17	15					0	0	1	0	0
RUSC2	9853	broad.mit.edu	37	9	35547741	35547741	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:35547741C>T	ENST00000455600.1	+	2	1792	c.1223C>T	c.(1222-1224)tCa>tTa	p.S408L		NM_001135999.1	NP_001129471.1	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	408						cytosol				NS(1)|breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|lung(4)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			TCTTCCCAATCATCCCCAAGC	0.567000													70	27					0	0	1	0	0
DENND3	22898	broad.mit.edu	37	8	142166030	142166030	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:142166030C>T	ENST00000519811.1	+	8	1227	c.1157C>T	c.(1156-1158)cCt>cTt	p.P386L	DENND3_ENST00000424248.1_Missense_Mutation_p.P306L|DENND3_ENST00000262585.2_Missense_Mutation_p.P306L			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	306	dDENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GTGGACATTCCTGATGTCCCC	0.448000													40	60					0	0	1	0	0
KRT28	162605	broad.mit.edu	37	17	38955946	38955946	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:38955946C>T	ENST00000306658.7	-	1	265	c.200G>A	c.(199-201)gGa>gAa	p.G67E		NM_181535.3	NP_853513.2	Q7Z3Y7	K1C28_HUMAN	keratin 28	67	Gly-rich.|Head.					cytoplasm|intermediate filament	structural molecule activity			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	30		Breast(137;0.000301)				AGCAGCATTTCCAAGGGCACC	0.537000													17	89					0	0	1	0	0
COL5A2	1290	broad.mit.edu	37	2	189926320	189926320	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:189926320C>T	ENST00000374866.3	-	30	2273	c.1999G>A	c.(1999-2001)Gaa>Aaa	p.E667K		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	667					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			GGTCCTTGTTCTCCTCTTTCA	0.373000													19	34					0	0	1	0	0
ACTG1P17	283693	broad.mit.edu	37	15	83395821	83395821	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:83395821G>A	ENST00000560958.1	-	0	465					NR_036446.1																						CCCCAAACATGATCTGAATCA	0.592000													8	5					0	0	1	0	0
SLC7A8	23428	broad.mit.edu	37	14	23597390	23597390	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:23597390G>A	ENST00000316902.7	-	10	2004	c.1279C>T	c.(1279-1281)Ccc>Tcc	p.P427S	SLC7A8_ENST00000422941.2_Missense_Mutation_p.P203S|SLC7A8_ENST00000529705.2_Missense_Mutation_p.P322S|SLC7A8_ENST00000453702.1_Missense_Mutation_p.P224S|SLC7A8_ENST00000469263.1_Intron	NM_012244.3	NP_036376.2	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, L system), member 8	427					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			autonomic_ganglia(1)|endometrium(6)|kidney(4)|large_intestine(6)|lung(5)|ovary(1)|skin(1)	24	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	TAGATGATGGGGAACAGCAGG	0.577000													17	5					0	0	1	0	0
UGT1A1	54658	broad.mit.edu	37	2	234678194	234678194	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:234678194G>A	ENST00000360418.3	+	5	1322	c.1322G>A	c.(1321-1323)gGa>gAa	p.G441E	UGT1A6_ENST00000406651.1_Missense_Mutation_p.G173E|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Missense_Mutation_p.G438E|UGT1A8_ENST00000373450.4_Intron|UGT1A4_ENST00000373409.3_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A3_ENST00000482026.1_Intron|UGT1A1_ENST00000305208.5_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A5_ENST00000373414.3_Intron			P22309	UD11_HUMAN		0					bilirubin conjugation|digestion|estrogen metabolic process|flavone metabolic process|heme catabolic process	endoplasmic reticulum membrane|microsome	enzyme binding|enzyme inhibitor activity|glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|retinoic acid binding|steroid binding			breast(1)|central_nervous_system(2)|endometrium(7)|large_intestine(5)|lung(9)|skin(4)|urinary_tract(2)	30		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;4.1e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000435)|Lung(119;0.00211)|LUSC - Lung squamous cell carcinoma(224;0.0054)	Abacavir(DB01048)|Adenine(DB00173)|Diclofenac(DB00586)|Estradiol(DB00783)|Ezetimibe(DB00973)|Irinotecan(DB00762)|Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|Propofol(DB00818)|Rifampin(DB01045)|Troglitazone(DB00197)	CAGCAGTCAGGAAGACAGATG	0.507000													17	31					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197390750	197390750	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:197390750C>T	ENST00000367400.3	+	6	1927	c.1792C>T	c.(1792-1794)Cca>Tca	p.P598S	CRB1_ENST00000543483.1_Intron|CRB1_ENST00000535699.1_Missense_Mutation_p.P529S|CRB1_ENST00000538660.1_Missense_Mutation_p.P598S|CRB1_ENST00000367397.1_5'UTR|CRB1_ENST00000544212.1_Missense_Mutation_p.P79S|CRB1_ENST00000367399.2_Missense_Mutation_p.P486S	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	598	Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						AGCTCCTACTCCACTTGAAAG	0.448000													20	95					0	0	1	0	0
ZPLD1	131368	broad.mit.edu	37	3	102175135	102175135	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:102175135C>T	ENST00000306176.1	+	4	574	c.474C>T	c.(472-474)atC>atT	p.I158I	ZPLD1_ENST00000491959.1_Silent_p.I142I|ZPLD1_ENST00000466937.1_Silent_p.I142I	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	142	ZP.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						CACCAACAATCATCAGCTATC	0.378000													59	77					0	0	1	0	0
FDX1	2230	broad.mit.edu	37	11	110327751	110327751	+	Silent	SNP	G	G	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:110327751G>C	ENST00000260270.2	+	3	658	c.420G>C	c.(418-420)ctG>ctC	p.L140L		NM_004109.4	NP_004100.1	P10109	ADX_HUMAN	ferredoxin 1	140	2Fe-2S ferredoxin-type.				electron transport chain|transport	mitochondrial matrix	2 iron, 2 sulfur cluster binding|electron carrier activity|iron ion binding			lung(2)	2		all_cancers(61;1.59e-12)|all_epithelial(67;8.38e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;8.54e-06)|all cancers(92;5.27e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0384)|Colorectal(284;0.228)	Mitotane(DB00648)	TGCTCGATCTGGCATATGGAC	0.388000													41	73					0	0	1	0	0
SPATA31D1	389763	broad.mit.edu	37	9	84605378	84605378	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:84605378G>A	ENST00000344803.2	+	3	326	c.279G>A	c.(277-279)agG>agA	p.R93R		NM_001001670.2	NP_001001670.1			SPATA31 subfamily D, member 1																		AAGAGGAAAGGAAGCTGCTTT	0.418000													5	2					0	0	1	0	0
NRF1	4899	broad.mit.edu	37	7	129349023	129349023	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:129349023C>T	ENST00000393232.1	+	6	832	c.715C>T	c.(715-717)Ccc>Tcc	p.P239S	NRF1_ENST00000393231.3_Missense_Mutation_p.P239S|NRF1_ENST00000223190.4_Missense_Mutation_p.P239S|NRF1_ENST00000539636.1_Missense_Mutation_p.P78S|NRF1_ENST00000311967.2_Missense_Mutation_p.P239S|NRF1_ENST00000353868.4_Missense_Mutation_p.P239S|NRF1_ENST00000393230.2_Missense_Mutation_p.P239S	NM_005011.3	NP_005002.3	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	239					generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	24						TGAAGATATCCCCTGGGCAAA	0.517000													69	111					0	0	1	0	0
LAMA3	3909	broad.mit.edu	37	18	21494816	21494816	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:21494816G>A	ENST00000313654.9	+	58	7877	c.7636G>A	c.(7636-7638)Gat>Aat	p.D2546N	LAMA3_ENST00000269217.6_Missense_Mutation_p.D937N|LAMA3_ENST00000399516.3_Missense_Mutation_p.D2490N|LAMA3_ENST00000588770.1_3'UTR|LAMA3_ENST00000587184.1_Missense_Mutation_p.D881N	NM_198129.1	NP_937762.1	Q16787	LAMA3_HUMAN	laminin, alpha 3	2546	Laminin G-like 1.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(24)|lung(54)|ovary(8)|prostate(6)|skin(7)|urinary_tract(4)	128	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTACCCACCTGATTTTAAAGT	0.303000													13	13					0	0	1	0	0
EPB41L1	2036	broad.mit.edu	37	20	34807691	34807691	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:34807691G>A	ENST00000338074.2	+	19	2525	c.2364G>A	c.(2362-2364)ggG>ggA	p.G788G	EPB41L1_ENST00000373946.3_Silent_p.G608G|EPB41L1_ENST00000373941.1_Silent_p.G787G|EPB41L1_ENST00000373950.2_Silent_p.G679G|EPB41L1_ENST00000441639.1_Silent_p.G686G|EPB41L1_ENST00000202028.5_Silent_p.G686G	NM_001258329.1|NM_012156.2	NP_001245258.1|NP_036288.2	Q9H4G0	E41L1_HUMAN	erythrocyte membrane protein band 4.1-like 1	788	Carboxyl-terminal (CTD).				cortical actin cytoskeleton organization|synaptic transmission	cytoskeleton|cytosol|extrinsic to membrane|plasma membrane	actin binding|structural molecule activity			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(10)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	37	Breast(12;0.0239)					AGATCATCGGGAAAGATGTCC	0.607000													21	77					0	0	1	0	0
PRSS1	5644	broad.mit.edu	37	7	142459791	142459791	+	Missense_Mutation	SNP	G	G	A	rs144403091		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:142459791G>A	ENST00000486171.1	+	4	426	c.409G>A	c.(409-411)Gtg>Atg	p.V137M	PRSS1_ENST00000311737.7_Missense_Mutation_p.V123M			P07477	TRY1_HUMAN	protease, serine, 1 (trypsin 1)	123	Peptidase S1.		T -> M (in a colorectal cancer sample; somatic mutation).		digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(24)|prostate(2)	38	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			CAACGCCCGCGTGTCCACCAT	0.587000													59	86					0	0	1	0	0
TMEM74	157753	broad.mit.edu	37	8	109796697	109796697	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:109796697C>T	ENST00000297459.3	-	2	809	c.631G>A	c.(631-633)Gcc>Acc	p.A211T	TMEM74_ENST00000518838.1_Intron	NM_153015.1	NP_694560.1	Q96NL1	TMM74_HUMAN	transmembrane protein 74	211					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			ATCTCCCGGGCTGCCACAGTG	0.617000													11	45					0	0	1	0	0
CLDN25	644672	broad.mit.edu	37	11	113651042	113651042	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:113651042C>T	ENST00000453129.2	+	1	574	c.525C>T	c.(523-525)ttC>ttT	p.F175F		NM_001101389.1	NP_001094859.1	C9JDP6	CLD25_HUMAN	claudin 25	175						integral to membrane|tight junction	structural molecule activity			large_intestine(1)|lung(6)|ovary(1)|urinary_tract(2)	10						CTGGTATTTTCCTGGCTCTTG	0.547000													17	21					0	0	1	0	0
RUSC1	23623	broad.mit.edu	37	1	155291627	155291627	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:155291627C>T	ENST00000368352.5	+	2	214	c.63C>T	c.(61-63)tcC>tcT	p.S21S	RUSC1_ENST00000368354.3_Silent_p.S21S|RUSC1-AS1_ENST00000450199.1_RNA|RUSC1-AS1_ENST00000443642.1_RNA	NM_001105203.1	NP_001098673.1	Q9BVN2	RUSC1_HUMAN	RUN and SH3 domain containing 1	21						cytoplasm|nucleolus	SH3/SH2 adaptor activity			breast(2)|endometrium(2)|kidney(2)|large_intestine(2)|liver(2)|lung(7)|ovary(2)|skin(1)|urinary_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;1.55e-10)|all cancers(21;4.15e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)			AGCACGTCTCCCTGGGCCTGC	0.617000													24	106					0	0	1	0	0
BAHCC1	57597	broad.mit.edu	37	17	79428633	79428633	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:79428633C>T	ENST00000307745.7	+	30	6944	c.6944C>T	c.(6943-6945)tCc>tTc	p.S2315F	RP11-1055B8.8_ENST00000572590.1_RNA																							GCCCGCCTGTCCGTGtcctct	0.692000													2	1					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145439538	145439538	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:145439538G>A	ENST00000511217.1	+	8	1717	c.1665G>A	c.(1663-1665)caG>caA	p.Q555Q	SH3RF2_ENST00000511705.1_3'UTR|SH3RF2_ENST00000359120.4_Silent_p.Q555Q			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	555							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AATTCTACCAGCCACAGGGGA	0.667000													34	36					0	0	1	0	0
RXFP3	51289	broad.mit.edu	37	5	33937213	33937213	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:33937213A>G	ENST00000330120.3	+	1	723	c.368A>G	c.(367-369)aAc>aGc	p.N123S		NM_016568.3	NP_057652.1	Q9NSD7	RL3R1_HUMAN	relaxin/insulin-like family peptide receptor 3	123						integral to plasma membrane	N-formyl peptide receptor activity			endometrium(4)|large_intestine(9)|lung(24)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)	42						TTCGTCACCAACCTGGCGCTG	0.587000													37	110					0	0	1	0	0
UBE2Z	65264	broad.mit.edu	37	17	47000226	47000226	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:47000226C>T	ENST00000360943.5	+	6	956	c.821C>T	c.(820-822)tCc>tTc	p.S274F		NM_023079.4	NP_075567.2	Q9H832	UBE2Z_HUMAN	ubiquitin-conjugating enzyme E2Z	274					apoptosis	cytoplasm|nucleus	ATP binding|ubiquitin-protein ligase activity										ATGGAGAAGTCCTTTCTGGAG	0.468000													8	9					0	0	1	0	0
POF1B	79983	broad.mit.edu	37	X	84561288	84561288	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:84561288G>C	ENST00000262753.4	-	12	1361	c.1216C>G	c.(1216-1218)Ctc>Gtc	p.L406V	POF1B_ENST00000373145.3_Missense_Mutation_p.L406V	NM_024921.3	NP_079197.3	Q8WVV4	POF1B_HUMAN	premature ovarian failure, 1B	406							actin binding			central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|liver(2)|lung(17)|ovary(1)|prostate(1)	35						CGAAGAGAGAGATTGTTTTCT	0.353000													43	14					0	0	1	0	0
CD2	914	broad.mit.edu	37	1	117297327	117297327	+	Missense_Mutation	SNP	C	C	T	rs142374557	byFrequency	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:117297327C>T	ENST00000369478.3	+	2	244	c.136C>T	c.(136-138)Cct>Tct	p.P46S	CD2_ENST00000369477.1_Missense_Mutation_p.P46S	NM_001767.3	NP_001758.2	P06729	CD2_HUMAN	CD2 molecule	46	Ig-like V-type.				blood coagulation|cell surface receptor linked signaling pathway|cell-cell adhesion|induction of apoptosis|leukocyte migration|membrane raft polarization|natural killer cell activation|positive regulation of myeloid dendritic cell activation|regulation of T cell differentiation|T cell activation	integral to plasma membrane	receptor activity			NS(1)|breast(2)|large_intestine(3)|liver(1)|lung(8)|skin(2)|stomach(1)	18	Lung SC(450;0.225)	all_cancers(81;3.15e-06)|Acute lymphoblastic leukemia(138;1.7e-08)|all_epithelial(167;8.38e-07)|all_lung(203;3.37e-06)|Lung NSC(69;2.31e-05)		Epithelial(280;6.71e-26)|OV - Ovarian serous cystadenocarcinoma(397;4.74e-24)|all cancers(265;1.93e-22)|Lung(183;0.0543)|Kidney(133;0.0813)|Colorectal(144;0.174)|KIRC - Kidney renal clear cell carcinoma(1967;0.176)|LUSC - Lung squamous cell carcinoma(189;0.189)|BRCA - Breast invasive adenocarcinoma(282;0.201)	Alefacept(DB00092)	CTTGGACATTCCTAGTTTTCA	0.378000													54	31					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92088127	92088127	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:92088127C>T	ENST00000298047.6	+	1	2866	c.2849C>T	c.(2848-2850)cCt>cTt	p.P950L	FAT3_ENST00000409404.2_Missense_Mutation_p.P950L|FAT3_ENST00000525166.1_Missense_Mutation_p.P800L|FAT3_ENST00000541502.1_Missense_Mutation_p.P950L			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	950	Cadherin 9.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GAAGATCTCCCTGTTGGCACT	0.433000										TCGA Ovarian(4;0.039)			38	44					0	0	1	0	0
PCDHB11	56125	broad.mit.edu	37	5	140580520	140580520	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140580520C>T	ENST00000354757.3	+	1	1173	c.1173C>T	c.(1171-1173)ttC>ttT	p.F391F	PCDHB11_ENST00000536699.1_Silent_p.F26F	NM_018931.2	NP_061754.1	Q9Y5F2	PCDBB_HUMAN		391	Cadherin 4.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			NS(2)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(23)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	63			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACCTCCCATTCGTGCTAAAAT	0.453000													39	71					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152420423	152420423	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:152420423C>T	ENST00000397345.3	-	118	18695	c.18493G>A	c.(18493-18495)Gag>Aag	p.E6165K	NEB_ENST00000603639.1_Missense_Mutation_p.E6165K|NEB_ENST00000604864.1_Missense_Mutation_p.E6165K|NEB_ENST00000409198.1_Missense_Mutation_p.E4464K|NEB_ENST00000172853.10_Missense_Mutation_p.E4464K|NEB_ENST00000427231.2_Missense_Mutation_p.E6165K	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	6159					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTGGTGCCCTCCCACGCCCCT	0.433000													3	8					0	0	1	0	0
RPH3A	22895	broad.mit.edu	37	12	113304595	113304595	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:113304595A>C	ENST00000389385.4	+	7	891	c.394A>C	c.(394-396)Aac>Cac	p.N132H	RPH3A_ENST00000420983.2_Missense_Mutation_p.N132H|RPH3A_ENST00000548866.1_Missense_Mutation_p.N83H|RPH3A_ENST00000415485.3_Missense_Mutation_p.N132H|RPH3A_ENST00000543106.2_Missense_Mutation_p.N132H|RPH3A_ENST00000447659.2_Missense_Mutation_p.N83H|RPH3A_ENST00000551052.1_Missense_Mutation_p.N128H	NM_001143854.1|NM_014954.3	NP_001137326.1|NP_055769.2	Q9Y2J0	RP3A_HUMAN	rabphilin 3A homolog (mouse)	132	RabBD.				intracellular protein transport	cell junction|synaptic vesicle	Rab GTPase binding|transporter activity|zinc ion binding			breast(1)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(16)|ovary(3)|prostate(4)|skin(6)|urinary_tract(1)	47				BRCA - Breast invasive adenocarcinoma(302;0.00453)		GGAGACCAACAACCGCCTGCA	0.567000													3	5					0	0	1	0	0
C12orf40	283461	broad.mit.edu	37	12	40114657	40114657	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:40114657G>A	ENST00000324616.5	+	13	1717	c.1563G>A	c.(1561-1563)aaG>aaA	p.K521K		NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	521										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						TCAAAACCAAGGAAAAAATGA	0.299000													17	40					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90052857	90052857	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:90052857C>T	ENST00000405460.2	+	57	11915	c.11819C>T	c.(11818-11820)cCt>cTt	p.P3940L		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3940					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		CTTCAAGTTCCTGTAGTCCGG	0.448000													25	28					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23905402	23905402	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:23905402T>C	ENST00000382298.3	-	10	13201	c.12613A>G	c.(12613-12615)Att>Gtt	p.I4205V	SACS_ENST00000382292.3_Missense_Mutation_p.I4205V|SACS_ENST00000402364.1_Missense_Mutation_p.I3455V	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	4205					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		TGTACAATAATTGCATATGTG	0.343000													33	30					0	0	1	0	0
PLK4	10733	broad.mit.edu	37	4	128807120	128807120	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:128807120T>A	ENST00000270861.5	+	5	869	c.595T>A	c.(595-597)Tgt>Agt	p.C199S	PLK4_ENST00000513090.1_Missense_Mutation_p.C167S|PLK4_ENST00000507249.1_Missense_Mutation_p.C199S|PLK4_ENST00000515069.1_Missense_Mutation_p.C199S|PLK4_ENST00000514379.1_Missense_Mutation_p.C158S	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	199	Protein kinase.				G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						GTCCCTGGGCTGTATGTTTTA	0.403000													72	32					0	0	1	0	0
C1orf177	163747	broad.mit.edu	37	1	55282732	55282732	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:55282732G>A	ENST00000358193.3	+	9	1175	c.1121G>A	c.(1120-1122)cGa>cAa	p.R374Q	C1orf177_ENST00000371273.3_Missense_Mutation_p.R374Q	NM_152607.2	NP_689820.2	Q3ZCV2	CA177_HUMAN	chromosome 1 open reading frame 177	374										breast(1)|cervix(1)|kidney(1)|large_intestine(6)|lung(6)|prostate(2)	17						CAGCGATATCGATCCCTATTC	0.592000													11	43					0	0	1	0	0
NETO2	81831	broad.mit.edu	37	16	47143405	47143405	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:47143405G>A	ENST00000562435.1	-	7	1256	c.872C>T	c.(871-873)tCc>tTc	p.S291F	NETO2_ENST00000303155.5_Missense_Mutation_p.S284F	NM_018092.4	NP_060562.3	Q8NC67	NETO2_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 2	291	CUB 2.					integral to membrane	receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	29		all_cancers(37;0.00114)|all_lung(18;0.00432)|Lung NSC(13;0.0384)|Breast(268;0.174)				CTCCACAAAGGAAGTAAAGAG	0.353000										HNSCC(25;0.065)			24	40					0	0	1	0	0
WFDC10B	280664	broad.mit.edu	37	20	44314568	44314568	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:44314568C>T	ENST00000330523.5	-	3	294	c.64G>A	c.(64-66)Gga>Aga	p.G22R	WFDC10B_ENST00000335769.2_Intron	NM_172006.2	NP_742003.1	Q8IUB3	WF10B_HUMAN	WAP four-disulfide core domain 10B	22						extracellular region	peptidase inhibitor activity			lung(2)|ovary(1)|stomach(1)	4		Myeloproliferative disorder(115;0.0122)				TCACGGTATCCTCCCTGGGCC	0.582000													11	25					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24509759	24509759	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:24509759A>C	ENST00000264463.4	-	7	1679	c.1172T>G	c.(1171-1173)tTt>tGt	p.F391C		NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	391	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		ATGAACTTCAAACAGATAGGA	0.388000										HNSCC(23;0.051)			8	58					0	0	1	0	0
FAM220A	84792	broad.mit.edu	37	7	6370260	6370260	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:6370260G>A	ENST00000313324.4	-	2	993	c.526C>T	c.(526-528)Ccc>Tcc	p.P176S		NM_001037163.1	NP_001032240.1	Q7Z4H9	SIPAR_HUMAN	family with sequence similarity 220, member A	176						nucleus											AGACCCTTGGGAAAAGCACTT	0.562000													36	43					0	0	1	0	0
MAPK4	5596	broad.mit.edu	37	18	48255617	48255617	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:48255617C>T	ENST00000400384.2	+	6	2193	c.1157C>T	c.(1156-1158)tCg>tTg	p.S386L	MAPK4_ENST00000592595.1_3'UTR|MAPK4_ENST00000540640.1_Missense_Mutation_p.S175L	NM_002747.3	NP_002738.2	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	386					cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(3)|upper_aerodigestive_tract(1)	8		Colorectal(6;0.0297)		Colorectal(21;0.156)		CGCGCGGGTTCGGCGCCACTG	0.697000													30	33					0	0	1	0	0
PM20D1	148811	broad.mit.edu	37	1	205814611	205814611	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:205814611G>A	ENST00000367136.4	-	3	375	c.331C>T	c.(331-333)Caa>Taa	p.Q111*	PM20D1_ENST00000460624.1_5'UTR	NM_152491.4	NP_689704.4	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1	111						extracellular region	metal ion binding|peptidase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)	28	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			TCCGAGCCTTGGATAGTGAAC	0.542000													28	125					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5428841	5428841	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:5428841G>A	ENST00000399537.4	-	5	962	c.614C>T	c.(613-615)cCa>cTa	p.P205L	TNRC18_ENST00000430969.1_Missense_Mutation_p.P205L			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	205							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CTCCTTGGCTGGACCGTCCCG	0.796000													3	2					0	0	1	0	0
OR52E2	119678	broad.mit.edu	37	11	5080848	5080848	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:5080848G>A	ENST00000321522.2	-	1	9	c.10C>T	c.(10-12)Ccc>Tcc	p.P4S		NM_001005164.2	NP_001005164.2	Q8NGJ4	O52E2_HUMAN	olfactory receptor, family 52, subfamily E, member 2	4					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(13)|ovary(2)|skin(3)	20		Medulloblastoma(188;0.0061)|all_neural(188;0.0479)|Breast(177;0.086)		Epithelial(150;1.03e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.191)		GTGTCATTGGGAAGGAACATC	0.498000													27	36					0	0	1	0	0
KBTBD7	84078	broad.mit.edu	37	13	41768146	41768146	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:41768146G>A	ENST00000379483.3	-	1	556	c.248C>T	c.(247-249)tCc>tTc	p.S83F		NM_032138.4	NP_115514.2	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	83	BTB.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(4)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		GCGATTGCAGGAAAAGAGGCG	0.607000													40	66					0	0	1	0	0
DPYSL2	1808	broad.mit.edu	37	8	26501043	26501043	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:26501043C>T	ENST00000311151.5	+	9	1312	c.900C>T	c.(898-900)gcC>gcT	p.A300A	DPYSL2_ENST00000523027.1_Silent_p.A264A|DPYSL2_ENST00000521913.1_Silent_p.A264A	NM_001386.5	NP_001377.1	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	300					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			breast(1)|endometrium(5)|large_intestine(8)|lung(3)|prostate(1)|skin(1)|stomach(1)	20		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		AGGCTGCTGCCTTTGTCACCT	0.557000													21	44					0	0	1	0	0
HRC	3270	broad.mit.edu	37	19	49654791	49654791	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:49654791G>T	ENST00000252825.4	-	5	2232	c.2046C>A	c.(2044-2046)ttC>ttA	p.F682L	HRC_ENST00000595625.1_Missense_Mutation_p.F659L	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	682					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		GGGACGAGGAGAAATAGTCAA	0.483000													9	19					0.00010058	0.000100933	1	1	0
MUC16	94025	broad.mit.edu	37	19	9090482	9090482	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:9090482G>A	ENST00000397910.4	-	1	1536	c.1333C>T	c.(1333-1335)Cct>Tct	p.P445S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	445	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTTCTCCAGGAGCAGAGGTC	0.478000													65	77					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179432270	179432270	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179432270G>A	ENST00000589042.1	-	326	78813	c.78589C>T	c.(78589-78591)Cca>Tca	p.P26197S	TTN_ENST00000342992.6_Missense_Mutation_p.P23629S|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P24556S|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.P17132S|TTN_ENST00000342175.6_Missense_Mutation_p.P17324S|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.P17257S|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24556	Fibronectin type-III 90.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGAATTTTGGATCCATTGAA	0.438000													15	21					0	0	1	0	0
STAP2	55620	broad.mit.edu	37	19	4328766	4328766	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:4328766G>A	ENST00000600324.1	-	6	563	c.496C>T	c.(496-498)Ctg>Ttg	p.L166L	STAP2_ENST00000594605.1_Silent_p.L166L	NM_017720.2	NP_060190.2	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2	166	SH2.					cytoplasm|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGCGCTCCAGGAGCAGTTGT	0.706000													6	6					0	0	1	0	0
BIRC6	57448	broad.mit.edu	37	2	32768346	32768346	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:32768346G>A	ENST00000421745.2	+	62	12464	c.12330G>A	c.(12328-12330)aaG>aaA	p.K4110K		NM_016252.3	NP_057336.3	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat containing 6	4110					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			NS(4)|breast(8)|central_nervous_system(3)|endometrium(21)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(31)|lung(65)|ovary(7)|pancreas(1)|prostate(5)|skin(5)|stomach(1)|urinary_tract(5)	172	Acute lymphoblastic leukemia(172;0.155)					CTCAGGAAAAGCCGAAGGATA	0.428000													32	41					0	0	1	0	0
AMELX	265	broad.mit.edu	37	X	11316847	11316847	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:11316847C>T	ENST00000380712.3	+	6	434	c.366C>T	c.(364-366)tcC>tcT	p.S122S	AMELX_ENST00000380714.3_Silent_p.S108S|ARHGAP6_ENST00000380732.3_Intron|ARHGAP6_ENST00000337414.4_Intron|ARHGAP6_ENST00000380736.1_Intron|ARHGAP6_ENST00000380718.1_Intron|ARHGAP6_ENST00000413512.3_Intron|AMELX_ENST00000348912.4_Silent_p.S92S	NM_182680.1	NP_872621.1	Q99217	AMELX_HUMAN	amelogenin, X-linked	108					cell adhesion|cell proliferation|chondrocyte differentiation|enamel mineralization|epithelial to mesenchymal transition|ion homeostasis|odontogenesis of dentine-containing tooth|osteoblast differentiation|positive regulation of collagen biosynthetic process|positive regulation of tooth mineralization|signal transduction	proteinaceous extracellular matrix	cell surface binding|growth factor activity|hydroxyapatite binding|identical protein binding|structural constituent of tooth enamel			endometrium(3)|kidney(2)|large_intestine(1)|lung(9)	15						GCCAACACTCCATGACTCCAA	0.637000													65	12					0	0	1	0	0
CCDC88C	440193	broad.mit.edu	37	14	91780201	91780201	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:91780201G>A	ENST00000389857.6	-	15	2045	c.1959C>T	c.(1957-1959)tcC>tcT	p.S653S		NM_001080414.3	NP_001073883.2	Q9P219	DAPLE_HUMAN	coiled-coil domain containing 88C	653					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			central_nervous_system(3)|endometrium(2)|kidney(3)|large_intestine(2)|lung(6)|ovary(6)|pancreas(1)|urinary_tract(1)	24		all_cancers(154;0.0468)				CTGTCTCCAGGGAGGTCACCT	0.632000													13	5					0	0	1	0	0
GIMAP8	155038	broad.mit.edu	37	7	150171641	150171641	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:150171641G>A	ENST00000307271.3	+	4	1798	c.1224G>A	c.(1222-1224)gaG>gaA	p.E408E		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	408						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GAGAAGAAGAGCAAAGGCAGG	0.418000													42	60					0	0	1	0	0
IGFBP6	3489	broad.mit.edu	37	12	53495900	53495900	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:53495900G>A	ENST00000548547.1	+	4	948	c.666G>A	c.(664-666)ggG>ggA	p.G222G	IGFBP6_ENST00000549628.1_3'UTR|IGFBP6_ENST00000301464.3_Silent_p.G224G			P24592	IBP6_HUMAN	insulin-like growth factor binding protein 6	224	Thyroglobulin type-1.				negative regulation of cell proliferation|regulation of cell growth|signal transduction					large_intestine(1)|lung(3)|ovary(1)|pancreas(1)	6						CCCTGCCAGGGTCTCCAGATG	0.642000													9	35					0	0	1	0	0
MIR587	693172	broad.mit.edu	37	6	107232029	107232029	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:107232029G>A	ENST00000384845.1	+	0	30					NR_030314.1																						cataggtgatgagtcacaggg	0.512000													55	48					0	0	1	0	0
WBP2NL	164684	broad.mit.edu	37	22	42422829	42422829	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:42422829C>T	ENST00000328823.9	+	6	605	c.574C>T	c.(574-576)Cca>Tca	p.P192S	WBP2NL_ENST00000543212.1_Missense_Mutation_p.P118S	NM_152613.2	NP_689826.2	Q6ICG8	WBP2L_HUMAN	WBP2 N-terminal like	192	10 X 7 AA tandem repeat of Y-G-X-P-P-X-G.|Gly-rich.				egg activation|male pronucleus assembly|meiosis	perinuclear theca	WW domain binding			breast(2)|large_intestine(3)|lung(5)|ovary(3)|prostate(1)	14						ATACGGAGCCCCACCTGCAGG	0.532000													79	37					0	0	1	0	0
GLRA3	8001	broad.mit.edu	37	4	175688114	175688114	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:175688114C>T	ENST00000274093.3	-	3	769	c.267_splice	c.e3+1	p.M89_splice	GLRA3_ENST00000340217.5_Splice_Site_p.M89_splice	NM_006529.2	NP_006520.2	O75311	GLRA3_HUMAN	glycine receptor, alpha 3	89					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	extracellular-glycine-gated chloride channel activity|glycine binding|receptor activity|transmitter-gated ion channel activity			endometrium(2)|kidney(1)|large_intestine(12)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	35		Prostate(90;0.00601)|Breast(14;0.0091)|Melanoma(52;0.00959)|Renal(120;0.0183)|all_neural(102;0.0891)|all_hematologic(60;0.107)		all cancers(43;4.99e-18)|Epithelial(43;1.18e-16)|OV - Ovarian serous cystadenocarcinoma(60;5.88e-09)|STAD - Stomach adenocarcinoma(60;0.00442)|GBM - Glioblastoma multiforme(59;0.0102)|LUSC - Lung squamous cell carcinoma(193;0.0421)	Glycine(DB00145)	AAATGCCTACCATGGTCGTCT	0.353000													9	45					0	0	1	0	0
LCN9	392399	broad.mit.edu	37	9	138556626	138556626	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:138556626G>A	ENST00000277526.3	+	3	292	c.292G>A	c.(292-294)Gaa>Aaa	p.E98K	LCN9_ENST00000430290.2_3'UTR	NM_001001676.1	NP_001001676.1	Q8WX39	LCN9_HUMAN	lipocalin 9	98						extracellular region	pheromone binding|transporter activity			kidney(1)|large_intestine(2)|lung(2)|urinary_tract(1)	6		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;3.43e-07)|Epithelial(140;1.97e-06)|all cancers(34;6.1e-05)		GAAGAATGGGGAATACTCCAT	0.597000													2	1					0	0	1	0	0
ACSM4	341392	broad.mit.edu	37	12	7469805	7469805	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:7469805G>A	ENST00000399422.4	+	4	741	c.693G>A	c.(691-693)ggG>ggA	p.G231G		NM_001080454.1	NP_001073923.1	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	231					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			endometrium(6)|kidney(1)|lung(14)	21						TCACCAGTGGGACCACAGGCT	0.498000													9	6					0	0	1	0	0
TYW1	55253	broad.mit.edu	37	7	66520842	66520842	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:66520842C>T	ENST00000359626.5	+	9	1287	c.1123C>T	c.(1123-1125)Cac>Tac	p.H375Y		NM_018264.2	NP_060734.2	Q9NV66	TYW1_HUMAN	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	375					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity			breast(1)|endometrium(8)|kidney(10)|large_intestine(4)|lung(13)|ovary(1)|prostate(2)|skin(3)|stomach(2)|urinary_tract(2)	46		Lung NSC(55;0.0846)|all_lung(88;0.183)				GATTGGGAGCCACTCGGGGGT	0.353000													9	17					0	0	1	0	0
KRT1	3848	broad.mit.edu	37	12	53069518	53069518	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:53069518C>T	ENST00000252244.3	-	8	1544	c.1486G>A	c.(1486-1488)Gaa>Aaa	p.E496K		NM_006121.3	NP_006112.3	P04264	K2C1_HUMAN	keratin 1	496	Tail.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(7)|skin(3)	39						GGGGCACATTCTCCAGACATC	0.498000													25	26					0	0	1	0	0
CAMK4	814	broad.mit.edu	37	5	110820146	110820146	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:110820146G>A	ENST00000282356.4	+	11	1802	c.1404G>A	c.(1402-1404)gtG>gtA	p.V468V	CAMK4_ENST00000512453.1_Silent_p.V468V|CAMK4_ENST00000512890.1_3'UTR	NM_001744.4	NP_001735.1	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	468					activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(13)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	30		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		AGCAAGATGTGATCCTGCCAG	0.498000													15	20					0	0	1	0	0
EEF1G	1937	broad.mit.edu	37	11	62340067	62340067	+	Missense_Mutation	SNP	G	G	A	rs11549641		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:62340067G>A	ENST00000378019.3	-	2	400	c.310C>T	c.(310-312)Cct>Tct	p.P104S	EEF1G_ENST00000329251.4_Missense_Mutation_p.P54S|MIR3654_ENST00000496634.2_3'UTR|EEF1G_ENST00000532986.1_5'UTR			P26641	EF1G_HUMAN	eukaryotic translation elongation factor 1 gamma	54	GST C-terminal.				response to virus	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|translation elongation factor activity			breast(2)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						TTGCCGGCAGGAAATTTGCGG	0.582000													50	84					0	0	1	0	0
PRSS21	10942	broad.mit.edu	37	16	2871029	2871029	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:2871029C>T	ENST00000455114.1	+	5	724	c.618C>T	c.(616-618)ttC>ttT	p.F206F	PRSS21_ENST00000575739.1_Intron|PRSS21_ENST00000450020.3_Silent_p.F208F|PRSS21_ENST00000005995.3_Silent_p.F208F	NM_001270452.1|NM_006799.3|NM_144956.2	NP_001257381.1|NP_006790.1|NP_659205.1	Q9Y6M0	TEST_HUMAN	protease, serine, 21 (testisin)	208	Peptidase S1.				proteolysis	anchored to membrane|cytoplasm|membrane fraction|plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	15						ACCACCTCTTCCTCAAGTACA	0.542000													148	231					0	0	1	0	0
SACS	26278	broad.mit.edu	37	13	23912907	23912907	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:23912907G>A	ENST00000382298.3	-	10	5696	c.5108C>T	c.(5107-5109)aCc>aTc	p.T1703I	SACS_ENST00000382292.3_Missense_Mutation_p.T1703I|SACS_ENST00000402364.1_Missense_Mutation_p.T953I	NM_014363.4	NP_055178.3	Q9NZJ4	SACS_HUMAN	spastic ataxia of Charlevoix-Saguenay (sacsin)	1703					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(54)|lung(49)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(11)	189		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		ACTGGGGTTGGTTTCCTCAAT	0.353000													10	32					0	0	1	0	0
FOXM1	2305	broad.mit.edu	37	12	2973534	2973534	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:2973534C>T	ENST00000342628.2	-	8	1331	c.1218G>A	c.(1216-1218)atG>atA	p.M406I	FOXM1_ENST00000359843.3_Missense_Mutation_p.M406I|FOXM1_ENST00000361953.3_Missense_Mutation_p.M391I	NM_202002.2	NP_973731.1	Q08050	FOXM1_HUMAN	forkhead box M1	406					cell cycle|embryo development|liver development|negative regulation of cell aging|negative regulation of stress-activated MAPK cascade|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of cell growth|regulation of cell proliferation|regulation of oxygen and reactive oxygen species metabolic process|regulation of Ras protein signal transduction|regulation of reactive oxygen species metabolic process|regulation of sequence-specific DNA binding transcription factor activity|tissue development|transcription from RNA polymerase II promoter|vasculogenesis	cytoplasm|transcription factor complex	DNA bending activity|DNA binding|double-stranded DNA binding|promoter binding|protein binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|transcription factor binding			breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|skin(1)|urinary_tract(3)	24			OV - Ovarian serous cystadenocarcinoma(31;0.000622)			GCTCTGAGCTCATGAGGGAAG	0.562000													75	57					0	0	1	0	0
SLIT2	9353	broad.mit.edu	37	4	20490460	20490460	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:20490460C>T	ENST00000504154.1	+	8	882	c.630C>T	c.(628-630)aaC>aaT	p.N210N	SLIT2_ENST00000273739.5_Silent_p.N210N|SLIT2_ENST00000503823.1_Silent_p.N210N|SLIT2_ENST00000503837.1_Silent_p.N210N	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	210	LRRCT 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						ATTCAAACAACCTGTATTGTG	0.448000													91	89					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179567356	179567356	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179567356G>A	ENST00000589042.1	-	107	30482	c.30258C>T	c.(30256-30258)aaC>aaT	p.N10086N	TTN_ENST00000342992.6_Silent_p.N8842N|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Silent_p.N9769N|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	9769	Glu-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCACCACGATGTTCTGTATGC	0.393000													17	45					0	0	1	0	0
OR1L6	392390	broad.mit.edu	37	9	125512113	125512113	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:125512113G>A	ENST00000373684.1	+	1	95	c.95G>A	c.(94-96)aGg>aAg	p.R32K				Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L, member 6	32					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	12						ACCCTATCCAGGAAGTCCAGA	0.483000													76	25					0	0	1	0	0
DRC1	92749	broad.mit.edu	37	2	26667169	26667169	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:26667169A>G	ENST00000288710.2	+	9	1182	c.1108A>G	c.(1108-1110)Acc>Gcc	p.T370A	DRC1_ENST00000483675.1_3'UTR	NM_145038.2	NP_659475.2			dynein regulatory complex subunit 1 homolog (Chlamydomonas)																		CCAGTCTCTAACCTCGGACTA	0.428000													8	30					0	0	1	0	0
OR2A25	392138	broad.mit.edu	37	7	143772039	143772039	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:143772039C>T	ENST00000408898.2	+	1	765	c.727C>T	c.(727-729)Cac>Tac	p.H243Y		NM_001004488.1	NP_001004488.1	A4D2G3	O2A25_HUMAN	olfactory receptor, family 2, subfamily A, member 25	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(16)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	24	Melanoma(164;0.0783)					CTGCTCCTCCCACCTCTGTGT	0.463000													27	108					0	0	1	0	0
KAL1	3730	broad.mit.edu	37	X	8507797	8507797	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:8507797G>A	ENST00000262648.3	-	10	1506	c.1357C>T	c.(1357-1359)Ccc>Tcc	p.P453S		NM_000216.2	NP_000207.2	P23352	KALM_HUMAN	Kallmann syndrome 1 sequence	453	Fibronectin type-III 3.				axon guidance|cell adhesion|cellular component movement	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|serine-type endopeptidase inhibitor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|liver(1)|lung(6)|ovary(3)|pancreas(1)|skin(3)|urinary_tract(1)	32						TTGACAGTGGGATCTATAATG	0.473000													6	13					0	0	1	0	0
CTNNA1	1495	broad.mit.edu	37	5	138117707	138117707	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:138117707C>T	ENST00000302763.7	+	2	184	c.94C>T	c.(94-96)Ctt>Ttt	p.L32F	CTNNA1_ENST00000355078.5_5'UTR|CTNNA1_ENST00000518825.1_Missense_Mutation_p.L32F	NM_001903.2	NP_001894.2	P35221	CTNA1_HUMAN	catenin (cadherin-associated protein), alpha 1, 102kDa	32	Involved in homodimerization.				adherens junction organization|apical junction assembly|cell adhesion|cellular response to indole-3-methanol|muscle cell differentiation|positive regulation of muscle cell differentiation	actin cytoskeleton|catenin complex|cytosol	beta-catenin binding|cadherin binding|gamma-catenin binding|structural molecule activity|vinculin binding			NS(1)|breast(7)|cervix(2)|endometrium(4)|kidney(6)|large_intestine(16)|lung(9)|oesophagus(2)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	52			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00325)			GTTGGAGCCTCTTGTTACACA	0.408000													13	21					0	0	1	0	0
HTR3A	3359	broad.mit.edu	37	11	113852011	113852011	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:113852011C>T	ENST00000504030.2	+	4	796	c.351C>T	c.(349-351)gtC>gtT	p.V117V	HTR3A_ENST00000535865.1_5'UTR|HTR3A_ENST00000299961.5_Silent_p.V102V|HTR3A_ENST00000506841.2_Silent_p.V117V|HTR3A_ENST00000375498.2_Silent_p.V123V|HTR3A_ENST00000355556.2_Silent_p.V123V			P46098	5HT3A_HUMAN	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	117					digestion|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	serotonin binding|serotonin receptor activity|serotonin-activated cation-selective channel activity			central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	36		all_cancers(61;2.31e-17)|all_epithelial(67;2.1e-10)|all_hematologic(158;4.64e-05)|Melanoma(852;0.000312)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|all_neural(223;0.0281)|Prostate(24;0.0294)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;2.71e-06)|Epithelial(105;2.58e-05)|all cancers(92;0.000238)|OV - Ovarian serous cystadenocarcinoma(223;0.191)	Alosetron(DB00969)|Chloroprocaine(DB01161)|Cisapride(DB00604)|Dolasetron(DB00757)|Granisetron(DB00889)|Mirtazapine(DB00370)|Ondansetron(DB00904)|Palonosetron(DB00377)|Procaine(DB00721)|Tubocurarine(DB01199)	GCATCTGGGTCCCGGACATTC	0.532000													16	26					0	0	1	0	0
RPSAP58	388524	broad.mit.edu	37	19	24010559	24010559	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:24010559C>T	ENST00000496398.1	+	4	1019	c.596C>T	c.(595-597)cCt>cTt	p.P199L	RPSAP58_ENST00000354585.4_Missense_Mutation_p.P199L|RP11-255H23.4_ENST00000599944.1_lincRNA|RP11-255H23.2_ENST00000471224.1_RNA																endometrium(1)|kidney(5)|lung(2)|prostate(1)|urinary_tract(1)	10						GAGGTCATGCCTGATCTGTAC	0.522000													9	13					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56329477	56329477	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:56329477C>T	ENST00000443188.1	-	4	774	c.64G>A	c.(64-66)Gaa>Aaa	p.E22K	NLRP11_ENST00000589093.1_Missense_Mutation_p.E22K|NLRP11_ENST00000592953.1_Intron|NLRP11_ENST00000360133.3_Missense_Mutation_p.E22K|NLRP11_ENST00000589824.2_Missense_Mutation_p.E22K	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	22	DAPIN.						ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CTCTGAAATTCCTTGTCACTG	0.433000													11	30					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158576567	158576567	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:158576567C>T	ENST00000361284.1	+	1	339	c.339C>T	c.(337-339)ttC>ttT	p.F113F		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	113					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					CTAACTGCTTCCTTCTGGCTG	0.557000													103	42					0	0	1	0	0
LECT1	11061	broad.mit.edu	37	13	53282826	53282826	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:53282826C>T	ENST00000448904.2	-	6	744	c.634G>A	c.(634-636)Gaa>Aaa	p.E212K	LECT1_ENST00000377962.3_Missense_Mutation_p.E212K	NM_001011705.1|NM_007015.2	NP_001011705.1|NP_008946.1	O75829	LECT1_HUMAN	leukocyte cell derived chemotaxin 1	212					cartilage development|proteoglycan metabolic process	endomembrane system|extracellular region|integral to membrane				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|urinary_tract(1)	15		Lung NSC(96;0.00212)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.38e-08)		TCTCTTCTTTCCCTCTGGATT	0.368000													26	54					0	0	1	0	0
EPX	8288	broad.mit.edu	37	17	56272394	56272394	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:56272394C>T	ENST00000225371.5	+	6	774	c.664C>T	c.(664-666)Ctc>Ttc	p.L222F		NM_000502.4	NP_000493.1	P11678	PERE_HUMAN	eosinophil peroxidase	222					hydrogen peroxide catabolic process		heme binding|peroxidase activity|protein binding	p.L222V(1)		breast(2)|endometrium(9)|kidney(1)|large_intestine(9)|liver(2)|lung(20)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	48						TGGCCGAGCCCTCATGTTCAT	0.597000													23	30					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124336119	124336119	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:124336119C>T	ENST00000338354.3	+	7	594	c.488C>T	c.(487-489)cCc>cTc	p.P163L	DMBT1_ENST00000344338.3_Missense_Mutation_p.P163L|DMBT1_ENST00000368955.3_Missense_Mutation_p.P163L|DMBT1_ENST00000359586.6_Missense_Mutation_p.P163L|DMBT1_ENST00000330163.4_Missense_Mutation_p.P163L|DMBT1_ENST00000368909.3_Missense_Mutation_p.P163L|DMBT1_ENST00000368956.2_Missense_Mutation_p.P163L			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	163	SRCR 1.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GGCTCAGGACCCATTGCCCTG	0.587000													6	126					0	0	1	0	0
PCDHGA5	56110	broad.mit.edu	37	5	140744029	140744029	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140744029C>T	ENST00000518069.1	+	1	132	c.132C>T	c.(130-132)ttC>ttT	p.F44F	PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018918.2|NM_032054.1	NP_061741.1|NP_114443.1														endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|upper_aerodigestive_tract(3)	18			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGGCTCCTTCGTCGGCAACA	0.642000													33	39					0	0	1	0	0
NLRP11	204801	broad.mit.edu	37	19	56321602	56321602	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:56321602G>A	ENST00000443188.1	-	5	1084	c.374C>T	c.(373-375)tCg>tTg	p.S125L	NLRP11_ENST00000589093.1_Missense_Mutation_p.S125L|NLRP11_ENST00000592953.1_Missense_Mutation_p.S26L|NLRP11_ENST00000360133.3_Missense_Mutation_p.S125L|NLRP11_ENST00000589824.2_Missense_Mutation_p.S125L	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	125							ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CACATCTGACGAAACGTCACG	0.383000													3	13					0	0	1	0	0
MFSD4	148808	broad.mit.edu	37	1	205555205	205555205	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:205555205C>T	ENST00000367147.4	+	6	1112	c.1019C>T	c.(1018-1020)cCc>cTc	p.P340L	MFSD4_ENST00000536357.1_Missense_Mutation_p.P253L|MFSD4_ENST00000539267.1_Missense_Mutation_p.P340L	NM_181644.4	NP_857595.3	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing 4	340					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			GTGGAGAAGCCCCTGTCTGTG	0.597000													11	58					0	0	1	0	0
CDH10	1008	broad.mit.edu	37	5	24491823	24491823	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:24491823C>T	ENST00000264463.4	-	11	2245	c.1738G>A	c.(1738-1740)Ggc>Agc	p.G580S	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	580	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		GTCAGTGTGCCTGTGCTGCTC	0.493000										HNSCC(23;0.051)			8	61					0	0	1	0	0
RGS3	5998	broad.mit.edu	37	9	116359103	116359103	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:116359103C>T	ENST00000374140.2	+	26	3676	c.3467C>T	c.(3466-3468)aCg>aTg	p.T1156M	RGS3_ENST00000462403.1_Missense_Mutation_p.T269M|RGS3_ENST00000350696.5_Missense_Mutation_p.T1156M|RGS3_ENST00000374134.3_Missense_Mutation_p.T477M|RGS3_ENST00000342620.5_Missense_Mutation_p.T126M|RGS3_ENST00000343817.5_Missense_Mutation_p.T875M|RGS3_ENST00000394646.3_Missense_Mutation_p.T549M|RGS3_ENST00000462143.1_Missense_Mutation_p.T477M	NM_144488.4	NP_652759.3	P49796	RGS3_HUMAN	regulator of G-protein signaling 3	1156	RGS.				inactivation of MAPK activity|regulation of G-protein coupled receptor protein signaling pathway	cytosol|nucleus|plasma membrane	GTPase activator activity|signal transducer activity	p.T269M(1)|p.T1052M(1)|p.T1156M(1)		cervix(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(22)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	48						CAGAGCGTCACGCGGGGCTGC	0.612000													30	20					0	0	1	0	0
CDH19	28513	broad.mit.edu	37	18	64235727	64235727	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:64235727G>A	ENST00000262150.2	-	3	708	c.416C>T	c.(415-417)tCg>tTg	p.S139L	CDH19_ENST00000540086.1_Missense_Mutation_p.S139L	NM_021153.2	NP_066976.1	Q9H159	CAD19_HUMAN	cadherin 19, type 2	139	Cadherin 1.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(22)|ovary(1)|prostate(3)|skin(7)	61		Esophageal squamous(42;0.0132)				ATTGATATCCGAAACTTTGAT	0.418000													31	49					0	0	1	0	0
DHX37	57647	broad.mit.edu	37	12	125437078	125437078	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:125437078G>A	ENST00000308736.2	-	21	2832	c.2734C>T	c.(2734-2736)Ccc>Tcc	p.P912S	DHX37_ENST00000544745.1_Missense_Mutation_p.P699S	NM_032656.3	NP_116045.2	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	912							ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(5)|cervix(1)|endometrium(9)|kidney(5)|large_intestine(11)|liver(1)|lung(27)|ovary(1)|prostate(2)|skin(3)	65	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		TGCATCTTGGGATCCACGAAG	0.662000													7	37					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58240915	58240915	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:58240915G>A	ENST00000377918.3	+	3	2771	c.2745G>A	c.(2743-2745)agG>agA	p.R915R		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	915					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		TGTCTGTTAGGGAGGCACTCA	0.473000													25	36					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	94066667	94066667	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:94066667G>A	ENST00000369303.4	-	5	1276	c.1092C>T	c.(1090-1092)acC>acT	p.T364T		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	364	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		ATATTCTGTAGGTCACATCGT	0.483000													12	51					0	0	1	0	0
AHDC1	27245	broad.mit.edu	37	1	27878359	27878359	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:27878359G>C	ENST00000374011.2	-	6	1236	c.268C>G	c.(268-270)Cgt>Ggt	p.R90G	AHDC1_ENST00000247087.5_Missense_Mutation_p.R90G|AHDC1_ENST00000482400.2_5'UTR	NM_001029882.2	NP_001025053.1	Q5TGY3	AHDC1_HUMAN	AT hook, DNA binding motif, containing 1	90	Pro-rich.						DNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(20)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	42		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;8.48e-25)|Colorectal(126;9.17e-09)|COAD - Colon adenocarcinoma(152;1.84e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00192)|BRCA - Breast invasive adenocarcinoma(304;0.00259)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0291)		GAGACAGGACGGGCTGCCCGT	0.731000													27	116					0	0	1	0	0
NUP98	4928	broad.mit.edu	37	11	3735152	3735152	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:3735152G>A	ENST00000324932.7	-	19	2893	c.2473C>T	c.(2473-2475)Cgc>Tgc	p.R825C	NUP98_ENST00000359171.4_Missense_Mutation_p.R825C|NUP98_ENST00000355260.3_Missense_Mutation_p.R825C|NUP98_ENST00000397004.4_Missense_Mutation_p.R825C|NUP98_ENST00000397007.4_Missense_Mutation_p.R842C	NM_016320.4|NM_139132.3	NP_057404.2|NP_624358.2	P52948	NUP98_HUMAN	nucleoporin 98kDa	842	Peptidase S59.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	66		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TCAGCAAGGCGATCTGGGCTC	0.403000			T	"""HOXA9, NSD1, WHSC1L1, DDX10, TOP1, HOXD13, PMX1, HOXA13, HOXD11, HOXA11, RAP1GDS1, HOXC11"""	AML								26	39					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70897082	70897082	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:70897082G>A	ENST00000393567.2	-	68	11625	c.11475C>T	c.(11473-11475)ttC>ttT	p.F3825F		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	3825								p.F3776F(1)|p.F3824F(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TAATCACATCGAACCTGCAAA	0.448000													10	19					0	0	1	0	0
DHX35	60625	broad.mit.edu	37	20	37634987	37634987	+	Missense_Mutation	SNP	C	C	T	rs149553143		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:37634987C>T	ENST00000252011.3	+	12	1243	c.1210C>T	c.(1210-1212)Cgc>Tgc	p.R404C	DHX35_ENST00000373325.2_Missense_Mutation_p.R404C|DHX35_ENST00000373323.4_Missense_Mutation_p.R373C	NM_021931.3	NP_068750.2	Q9H5Z1	DHX35_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 35	404	Helicase C-terminal.					catalytic step 2 spliceosome	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|urinary_tract(2)	40		Myeloproliferative disorder(115;0.00878)				AAAATGTTATCGCCTTTATAC	0.483000													57	90					0	0	1	0	0
ASPH	444	broad.mit.edu	37	8	62593567	62593567	+	Silent	SNP	A	A	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:62593567A>C	ENST00000541428.1	-	3	355	c.195T>G	c.(193-195)ggT>ggG	p.G65G	ASPH_ENST00000517903.1_Silent_p.G80G|ASPH_ENST00000518068.1_Silent_p.G94G|ASPH_ENST00000517661.1_Silent_p.G80G|ASPH_ENST00000522835.1_Silent_p.G80G|ASPH_ENST00000517847.2_Silent_p.G80G|ASPH_ENST00000389204.4_Silent_p.G80G|ASPH_ENST00000356457.5_Silent_p.G94G|ASPH_ENST00000379449.6_Silent_p.G109G|ASPH_ENST00000517856.1_Silent_p.G94G|ASPH_ENST00000379454.4_Silent_p.G94G|ASPH_ENST00000445642.3_Silent_p.G80G|ASPH_ENST00000522603.1_Silent_p.G65G	NM_001164750.1	NP_001158222.1	Q12797	ASPH_HUMAN	aspartate beta-hydroxylase	94					muscle contraction	integral to endoplasmic reticulum membrane	calcium ion binding|electron carrier activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|structural constituent of muscle			breast(1)|cervix(1)|endometrium(5)|large_intestine(5)|lung(16)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35	Lung SC(2;0.153)	Lung NSC(129;0.0358)|all_lung(136;0.0654)|all_epithelial(80;0.101)			L-Aspartic Acid(DB00128)|Succinic acid(DB00139)	AATCTCCATCACCATCAGCAT	0.294000													32	52					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203523	140203523	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140203523G>A	ENST00000529859.1	+	1	2163	c.2163G>A	c.(2161-2163)cgG>cgA	p.R721R	PCDHA5_ENST00000529619.1_Silent_p.R721R|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000378126.3_Silent_p.R721R|PCDHA4_ENST00000530339.1_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCGCTGCGGTGCTCGGCGC	0.667000													24	68					0	0	1	0	0
ATP6V1B2	526	broad.mit.edu	37	8	20069207	20069207	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:20069207C>T	ENST00000276390.2	+	7	688	c.648C>T	c.(646-648)tcC>tcT	p.S216S		NM_001693.3	NP_001684.2	P21281	VATB2_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2	216					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|endomembrane system|Golgi apparatus|melanosome|plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			endometrium(1)|kidney(2)|lung(5)|prostate(1)	9				Colorectal(74;0.0535)|COAD - Colon adenocarcinoma(73;0.211)		TAAAGAAATCCAAAGATGTAG	0.328000													24	24					0	0	1	0	0
KIAA1958	158405	broad.mit.edu	37	9	115337401	115337401	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:115337401C>T	ENST00000337530.6	+	2	1337	c.1041C>T	c.(1039-1041)ccC>ccT	p.P347P	KIAA1958_ENST00000536272.1_Silent_p.P347P|KIAA1958_ENST00000374244.3_Silent_p.P347P	NM_133465.2	NP_597722.1	Q8N8K9	K1958_HUMAN	KIAA1958	347										endometrium(1)|large_intestine(9)|lung(10)|prostate(2)|skin(3)	25						CCCATCTGCCCAGCCAGGTCT	0.562000													70	32					0	0	1	0	0
PLCH1	23007	broad.mit.edu	37	3	155241715	155241715	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:155241715C>T	ENST00000460012.1	-	11	1708	c.1351G>A	c.(1351-1353)Gaa>Aaa	p.E451K	PLCH1_ENST00000447496.2_Missense_Mutation_p.E469K|PLCH1_ENST00000414191.1_Missense_Mutation_p.E451K|PLCH1_ENST00000340059.7_Missense_Mutation_p.E469K|PLCH1_ENST00000334686.6_Missense_Mutation_p.E451K|PLCH1_ENST00000494598.1_Missense_Mutation_p.E469K			Q4KWH8	PLCH1_HUMAN	phospholipase C, eta 1	469					lipid catabolic process|phosphatidylinositol-mediated signaling	membrane	calcium ion binding|calcium-dependent phospholipase C activity|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(3)|breast(3)|endometrium(9)|kidney(4)|large_intestine(20)|lung(45)|ovary(2)|prostate(5)|skin(8)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	107			Lung(72;0.11)|LUSC - Lung squamous cell carcinoma(72;0.114)			CACTCGTCTTCAATTTCATCT	0.408000													56	85					0	0	1	0	0
FBXO43	286151	broad.mit.edu	37	8	101153160	101153160	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:101153160G>A	ENST00000428847.2	-	2	1638	c.1322C>T	c.(1321-1323)cCa>cTa	p.P441L		NM_001029860.3	NP_001025031.2	Q4G163	FBX43_HUMAN	F-box protein 43	441					meiosis		zinc ion binding			endometrium(1)|kidney(4)|large_intestine(5)|lung(14)|prostate(1)|skin(5)|urinary_tract(1)	31	all_cancers(14;0.000139)|all_epithelial(15;2.84e-07)|Lung NSC(17;0.000274)|all_lung(17;0.000798)		Epithelial(11;1.17e-09)|all cancers(13;1.34e-07)|OV - Ovarian serous cystadenocarcinoma(57;3.82e-05)|STAD - Stomach adenocarcinoma(118;0.0957)			TTGCAAGGCTGGGGTCTTTGA	0.433000													45	79					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	68535278	68535278	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:68535278C>T	ENST00000433211.1	-	8	1226	c.1052G>A	c.(1051-1053)gGa>gAa	p.G351E	CTNNA3_ENST00000494580.1_5'UTR|CTNNA3_ENST00000373744.4_Missense_Mutation_p.G351E	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	351					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						TTCTTTTTTTCCAGCCTGCAA	0.358000													35	24					0	0	1	0	0
CPED1	79974	broad.mit.edu	37	7	120770249	120770249	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:120770249G>A	ENST00000310396.5	+	12	1945	c.1478G>A	c.(1477-1479)gGa>gAa	p.G493E	CPED1_ENST00000423795.1_Missense_Mutation_p.G273E|CPED1_ENST00000450913.2_Missense_Mutation_p.G493E	NM_024913.4	NP_079189.4			cadherin-like and PC-esterase domain containing 1																		AATCCTGTGGGAAATCCTGGC	0.393000													23	46					0	0	1	0	0
C22orf42	150297	broad.mit.edu	37	22	32550253	32550253	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:32550253C>T	ENST00000382097.3	-	2	357	c.285G>A	c.(283-285)ggG>ggA	p.G95G		NM_001010859.1	NP_001010859.1	Q6IC83	CV042_HUMAN	chromosome 22 open reading frame 42	95										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(2)	24						GAGGCCAAATCCCGTGCCGTC	0.368000													27	11					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189349307	189349307	+	Translation_Start_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:189349307G>A	ENST00000264731.3	+	1	92	c.3G>A	c.(1-3)atG>atA	p.M1I	TP63_ENST00000320472.5_Start_Codon_SNP_p.M1I|TP63_ENST00000440651.2_Start_Codon_SNP_p.M1I|TP63_ENST00000392460.3_Start_Codon_SNP_p.M1I|TP63_ENST00000418709.2_Start_Codon_SNP_p.M1I|TP63_ENST00000382063.4_Start_Codon_SNP_p.M1I	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	1	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		TGAAGGAAATGAATTTTGAAA	0.373000										HNSCC(45;0.13)			24	87					0	0	1	0	0
GZF1	64412	broad.mit.edu	37	20	23345093	23345093	+	Missense_Mutation	SNP	C	C	T	rs140549788		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:23345093C>T	ENST00000338121.5	+	2	150	c.73C>T	c.(73-75)Cgc>Tgc	p.R25C	GZF1_ENST00000544236.1_Intron|GZF1_ENST00000542987.1_Intron|GZF1_ENST00000377051.2_Missense_Mutation_p.R25C			Q9H116	GZF1_HUMAN	GDNF-inducible zinc finger protein 1	25					transcription, DNA-dependent	nucleolus|nucleoplasm	sequence-specific DNA binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(7)|prostate(1)|urinary_tract(2)	24	Lung NSC(19;0.0605)|Colorectal(13;0.0993)|all_lung(19;0.135)					GCATGAGCTTCGCCTCCTGGG	0.522000													36	24					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228559048	228559048	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:228559048C>T	ENST00000570156.2	+	105	23514	c.23440C>T	c.(23440-23442)Cca>Tca	p.P7814S	OBSCN_ENST00000366707.4_Missense_Mutation_p.P4491S|OBSCN_ENST00000422127.1_Missense_Mutation_p.P6857S	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	6857	Protein kinase 2.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GGGTGCCGGGCCACCGGCCGC	0.756000													3	11					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55872770	55872770	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:55872770G>A	ENST00000313503.1	+	1	252	c.252G>A	c.(250-252)gcG>gcA	p.A84A		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	84					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					AAACCTTAGCGAACTTACTGA	0.438000										HNSCC(53;0.14)			72	344					0	0	1	0	0
ALX3	257	broad.mit.edu	37	1	110604121	110604121	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:110604121C>T	ENST00000369792.4	-	3	746	c.659G>A	c.(658-660)gGg>gAg	p.G220E	RP4-773N10.4_ENST00000554749.1_RNA	NM_006492.2	NP_006483.2	O95076	ALX3_HUMAN	ALX homeobox 3	220						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6		all_cancers(81;2.35e-05)|all_epithelial(167;7.69e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.015)|all cancers(265;0.0706)|Epithelial(280;0.0758)|Colorectal(144;0.113)|LUSC - Lung squamous cell carcinoma(189;0.135)		GGGGTTCCGCCCCTCCTGGAT	0.622000													22	99					0	0	1	0	0
SRPK1	6732	broad.mit.edu	37	6	35856643	35856643	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:35856643C>T	ENST00000373825.2	-	4	536	c.251G>A	c.(250-252)cGa>cAa	p.R84Q	SRPK1_ENST00000373821.2_5'UTR|SRPK1_ENST00000423325.2_Missense_Mutation_p.R68Q|SRPK1_ENST00000373822.1_5'UTR			Q96SB4	SRPK1_HUMAN	SRSF protein kinase 1	84	Protein kinase.				cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(10)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21						GCCTAACTTTCGGATCACATG	0.373000													61	51					0	0	1	0	0
OR2L8	391190	broad.mit.edu	37	1	248112454	248112454	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:248112454C>T	ENST00000357191.3	+	1	295	c.295C>T	c.(295-297)Cag>Tag	p.Q99*	OR2L13_ENST00000366478.2_Intron	NM_001001963.1	NP_001001963.1	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L, member 8 (gene/pseudogene)	99					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(3)|large_intestine(3)|lung(30)|ovary(1)|prostate(1)|skin(3)	42	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			GTGTGGGATTCAGAGTTTCTT	0.428000													24	286					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55925714	55925714	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:55925714C>T	ENST00000244728.5	-	26	2724	c.2327G>A	c.(2326-2328)gGa>gAa	p.G776E	COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000535941.1_Missense_Mutation_p.G776E|COL21A1_ENST00000370808.2_Missense_Mutation_p.G176E|COL21A1_ENST00000370819.1_Missense_Mutation_p.G773E	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	776	Collagen-like 5.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			ACCTGGGGGTCCCTGAGGACC	0.493000													18	17					0	0	1	0	0
CT45A5	441521	broad.mit.edu	37	X	134947928	134947928	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:134947928C>T	ENST00000370724.3	-	3	641	c.397G>A	c.(397-399)Gaa>Aaa	p.E133K	CT45A4_ENST00000420087.2_Intron|CT45A5_ENST00000491480.1_Missense_Mutation_p.E133K	NM_001007551.3|NM_001172288.1	NP_001007552.1|NP_001165759.1	Q6NSH3	CT455_HUMAN	cancer/testis antigen family 45, member A5	133								p.E133*(1)		endometrium(1)|large_intestine(2)|lung(6)	9						CATCGGATTTCCTTCACTACT	0.388000													43	15					0	0	1	0	0
ZNF93	81931	broad.mit.edu	37	19	20044767	20044767	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:20044767C>T	ENST00000343769.5	+	4	1031	c.1003C>T	c.(1003-1005)Cat>Tat	p.H335Y	AC007204.2_ENST00000592245.1_lincRNA	NM_031218.3	NP_112495.2	P35789	ZNF93_HUMAN	zinc finger protein 93	335						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(6)|kidney(2)|large_intestine(4)|lung(8)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	24						TAAGAGAATTCATACTGGAGA	0.373000													14	28					0	0	1	0	0
ZSCAN23	222696	broad.mit.edu	37	6	28403841	28403841	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:28403841C>T	ENST00000289788.4	-	2	348	c.203G>A	c.(202-204)aGa>aAa	p.R68K	ZSCAN23_ENST00000486481.1_Intron	NM_001012455.1	NP_001012458.1	Q3MJ62	ZSC23_HUMAN	zinc finger and SCAN domain containing 23	68	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|prostate(1)|stomach(2)	4						CTCCTGGAGTCTTTGAAGAGC	0.557000													21	49					0	0	1	0	0
AMPH	273	broad.mit.edu	37	7	38457541	38457541	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:38457541C>T	ENST00000356264.2	-	17	1497	c.1282G>A	c.(1282-1284)Gaa>Aaa	p.E428K	AMPH_ENST00000428293.2_Intron|AMPH_ENST00000471913.1_Intron|AMPH_ENST00000325590.5_Intron	NM_001635.3	NP_001626.1	P49418	AMPH_HUMAN	amphiphysin	428					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				breast(1)|endometrium(3)|kidney(3)|large_intestine(12)|liver(3)|lung(27)|ovary(3)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)	62						GGAGCCTGTTCAGATTCAGCC	0.473000													25	105					0	0	1	0	0
PCK1	5105	broad.mit.edu	37	20	56137260	56137260	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:56137260G>A	ENST00000319441.4	+	3	522	c.358G>A	c.(358-360)Gag>Aag	p.E120K	PCK1_ENST00000543666.1_Intron|PCK1_ENST00000535860.1_Intron	NM_002591.3	NP_002582.3	P35558	PCKGC_HUMAN	phosphoenolpyruvate carboxykinase 1 (soluble)	120					gluconeogenesis|glucose homeostasis|glycerol biosynthetic process from pyruvate|response to insulin stimulus	cytosol|nucleus	carboxylic acid binding|GTP binding|magnesium ion binding|manganese ion binding|phosphoenolpyruvate carboxykinase (GTP) activity			endometrium(2)|kidney(1)|large_intestine(4)|liver(2)|lung(19)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	34	Lung NSC(12;0.000764)|all_lung(29;0.00264)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(13;9.88e-12)|Epithelial(14;3.41e-08)|all cancers(14;2.13e-07)			GATGTCAGAGGAGGATTTTGA	0.502000													13	47					0	0	1	0	0
IGHV4OR15-8	28317	broad.mit.edu	37	15	22473063	22473063	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:22473063C>T	ENST00000557788.2	-	0	207																											TGATAGATTTCCCCAATCCAC	0.567000													24	248					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	68526081	68526081	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:68526081C>T	ENST00000433211.1	-	9	1396	c.1222G>A	c.(1222-1224)Gaa>Aaa	p.E408K	CTNNA3_ENST00000494580.1_5'UTR|CTNNA3_ENST00000373744.4_Missense_Mutation_p.E408K	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	408					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						ATTTCCTTTTCCCGGCCATTC	0.433000													30	35					0	0	1	0	0
LILRA1	11024	broad.mit.edu	37	19	55106746	55106746	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:55106746C>T	ENST00000453777.1	+	5	710	c.540C>T	c.(538-540)gcC>gcT	p.A180A	LILRA1_ENST00000473156.1_3'UTR|LILRB1_ENST00000448689.1_Intron|LILRB1_ENST00000418536.2_Intron|LILRB1_ENST00000396321.2_Intron|LILRA1_ENST00000251372.3_Silent_p.A180A	NM_001278318.1	NP_001265247.1	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1	180	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	47				GBM - Glioblastoma multiforme(193;0.0348)		GGTCCCGGGCCATCTTCTCTG	0.567000													72	85					0	0	1	0	0
ILDR1	286676	broad.mit.edu	37	3	121725893	121725893	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:121725893C>T	ENST00000273691.3	-	2	279	c.174G>A	c.(172-174)gtG>gtA	p.V58V	ILDR1_ENST00000460554.1_5'UTR|ILDR1_ENST00000462014.1_Silent_p.V70V|ILDR1_ENST00000393631.1_Silent_p.V58V|ILDR1_ENST00000344209.5_Silent_p.V58V	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	58	Ig-like V-type.					cytosol|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		AGCGCCATGTCACCACCACGT	0.542000													29	29					0	0	1	0	0
KRT34	3885	broad.mit.edu	37	17	39535397	39535397	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:39535397C>T	ENST00000394001.1	-	6	1064	c.1034G>A	c.(1033-1035)aGc>aAc	p.S345N		NM_021013.3	NP_066293.2	O76011	KRT34_HUMAN	keratin 34	345	Coil 2.|Rod.				epidermis development	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Breast(137;0.000496)				GTGGGCCTCGCTCTCCGTCAG	0.572000													23	55					0	0	1	0	0
SCN8A	6334	broad.mit.edu	37	12	52163680	52163680	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:52163680G>A	ENST00000354534.5	+	18	3579	c.3401G>A	c.(3400-3402)gGa>gAa	p.G1134E	SCN8A_ENST00000545061.1_Missense_Mutation_p.G1134E	NM_001177984.2|NM_014191.3	NP_001171455.1|NP_055006.1	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha subunit	1134					axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(19)|ovary(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	TCCTCTGAAGGAAGCACCATT	0.507000													10	6					0	0	1	0	0
SEMG2	6407	broad.mit.edu	37	20	43851562	43851562	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:43851562C>T	ENST00000372769.3	+	2	1379	c.1289C>T	c.(1288-1290)tCc>tTc	p.S430F		NM_003008.2	NP_002999.1	Q02383	SEMG2_HUMAN	semenogelin II	430	4 X 60 AA tandem repeats, type I.|Repeat-rich region.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			autonomic_ganglia(1)|breast(3)|endometrium(6)|kidney(2)|large_intestine(6)|lung(9)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	36		Myeloproliferative disorder(115;0.0122)				AAAGGTGTATCCAAAGGCAGT	0.383000													34	67					0	0	1	0	0
CAD	790	broad.mit.edu	37	2	27446839	27446839	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:27446839C>T	ENST00000264705.4	+	8	1212	c.1050C>T	c.(1048-1050)ttC>ttT	p.F350F	CAD_ENST00000403525.1_Silent_p.F350F	NM_004341.3	NP_004332.2	P27708	PYR1_HUMAN	carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase	350	GATase (Glutamine amidotransferase).|Glutamine amidotransferase type-1.				'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			NS(1)|breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(40)|ovary(6)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	92	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	AACTGCTTTTCGATATCTTTC	0.498000													88	86					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41459205	41459205	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:41459205C>T	ENST00000400454.1	-	22	4337	c.3860G>A	c.(3859-3861)cGa>cAa	p.R1287Q		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1287	Ig-like C2-type 10.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GGTCAGGATTCGTGCAGGAGC	0.483000													45	55					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111482604	111482604	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:111482604G>A	ENST00000265162.5	+	20	3106	c.2764G>A	c.(2764-2766)Gaa>Aaa	p.E922K	ENPEP_ENST00000504100.1_3'UTR	NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	922					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	TGGAGCAGGAGAAAAACCTAG	0.358000													23	13					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117302341	117302341	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:117302341G>A	ENST00000321322.6	-	31	5464	c.5463C>T	c.(5461-5463)acC>acT	p.T1821T	DSCAML1_ENST00000527706.1_Silent_p.T1551T	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1761					axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CGGAGGTGAGGGTGCGGGCAG	0.627000													21	106					0	0	1	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913440	77913440	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:77913440C>T	ENST00000321110.1	-	2	773	c.478G>A	c.(478-480)Gat>Aat	p.D160N		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	160	Pro-rich.						nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						TTTGGGGGATCCTGGGGTTCT	0.562000													25	8					0	0	1	0	0
ST8SIA4	7903	broad.mit.edu	37	5	100222075	100222075	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:100222075C>T	ENST00000231461.5	-	3	785	c.475G>A	c.(475-477)Gag>Aag	p.E159K	ST8SIA4_ENST00000451528.2_Missense_Mutation_p.E159K|ST8SIA4_ENST00000507360.2_5'UTR	NM_005668.4	NP_005659.1	Q92187	SIA8D_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	159					axon guidance|N-glycan processing	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(11)|lung(7)|stomach(1)|upper_aerodigestive_tract(1)	25		all_cancers(142;1.5e-07)|all_epithelial(76;1.43e-10)|Prostate(80;0.000644)|Lung NSC(167;0.0059)|all_lung(232;0.00914)|Ovarian(225;0.024)|Colorectal(57;0.09)|Breast(839;0.203)		COAD - Colon adenocarcinoma(37;0.00402)		CTGTCAATCTCCTTTCCACAT	0.383000													24	37					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179629430	179629430	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179629430G>A	ENST00000589042.1	-	42	10036	c.9812C>T	c.(9811-9813)tCc>tTc	p.S3271F	TTN_ENST00000342992.6_Missense_Mutation_p.S3271F|TTN_ENST00000591111.1_Missense_Mutation_p.S3271F|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000360870.5_Missense_Mutation_p.S3271F|TTN_ENST00000460472.2_Missense_Mutation_p.S3225F|TTN_ENST00000342175.6_Missense_Mutation_p.S3225F|TTN_ENST00000359218.5_Missense_Mutation_p.S3225F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3000	Ig-like 19.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTGTACCAGGAAATTTTGGG	0.527000													44	80					0	0	1	0	0
PEBP4	157310	broad.mit.edu	37	8	22777793	22777793	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:22777793C>T	ENST00000256404.6	-	3	253	c.162G>A	c.(160-162)ggG>ggA	p.G54G	PEBP4_ENST00000521284.1_5'UTR	NM_144962.2	NP_659399.2	Q96S96	PEBP4_HUMAN	phosphatidylethanolamine-binding protein 4	54						lysosome				breast(1)|large_intestine(2)|lung(3)|ovary(1)|skin(1)|stomach(2)	10		Prostate(55;0.0453)|Breast(100;0.103)		Colorectal(74;0.0434)|COAD - Colon adenocarcinoma(73;0.124)		AGCCAATGTTCCCCAACTCTG	0.537000													33	38					0	0	1	0	0
AFP	174	broad.mit.edu	37	4	74313347	74313347	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:74313347G>A	ENST00000395792.2	+	8	1112	c.1012G>A	c.(1012-1014)Gat>Aat	p.D338N	AFP_ENST00000226359.2_Missense_Mutation_p.D338N	NM_001134.1	NP_001125.1	P02771	FETA_HUMAN	alpha-fetoprotein	338	Albumin 2.				transport		metal ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(13)|ovary(1)|skin(1)|urinary_tract(1)	22	Breast(15;0.00102)		Epithelial(6;2.42e-05)|all cancers(17;0.000268)|OV - Ovarian serous cystadenocarcinoma(6;0.000324)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AGGAGATAGAGATTTTAACCA	0.358000									Alpha-Fetoprotein, Hereditary Persistence of				7	32					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515899	140515899	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140515899G>A	ENST00000231134.5	+	1	1100	c.883G>A	c.(883-885)Gag>Aag	p.E295K		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		295	Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding	p.E295K(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGTAATAGACGAGAAAACAGC	0.458000													36	78					0	0	1	0	0
OR14K1	343170	broad.mit.edu	37	1	247902602	247902602	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:247902602G>A	ENST00000283225.2	+	1	686	c.686G>A	c.(685-687)aGa>aAa	p.R229K	RP11-634B7.4_ENST00000449298.1_RNA					olfactory receptor, family 14, subfamily K, member 1											NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|lung(18)|ovary(1)|urinary_tract(1)	27						ATATCACAGAGACAGAGACAA	0.418000													9	49					0	0	1	0	0
CNIH3	149111	broad.mit.edu	37	1	224868717	224868717	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:224868717C>T	ENST00000272133.3	+	2	1021	c.139C>T	c.(139-141)Cct>Tct	p.P47S		NM_152495.1	NP_689708.1	Q8TBE1	CNIH3_HUMAN	cornichon family AMPA receptor auxiliary protein 3	47					intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|postsynaptic membrane				large_intestine(5)|lung(4)	9	Breast(184;0.218)			GBM - Glioblastoma multiforme(131;0.073)		CCAGTGCAATCCTGTTCATGC	0.483000													15	76					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430961	37430961	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:37430961G>A	ENST00000374660.1	+	7	1067	c.968G>A	c.(967-969)aGa>aAa	p.R323K	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.R323K|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.R323K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	379						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						GCAAAAGGAAGACCTAGGAAG	0.428000													44	35					0	0	1	0	0
CAND2	23066	broad.mit.edu	37	3	12858301	12858301	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:12858301G>A	ENST00000456430.2	+	10	1911	c.1870G>A	c.(1870-1872)Gag>Aag	p.E624K	CAND2_ENST00000295989.5_Missense_Mutation_p.E531K	NM_001162499.1	NP_001155971.1	O75155	CAND2_HUMAN	cullin-associated and neddylation-dissociated 2 (putative)	624					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(8)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						CCTGCGGAATGAGATCACCCG	0.632000													58	123					0	0	1	0	0
OR5B12	390191	broad.mit.edu	37	11	58207445	58207445	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:58207445G>A	ENST00000302572.2	-	1	201	c.180C>T	c.(178-180)ttC>ttT	p.F60F		NM_001004733.2	NP_001004733.1	Q96R08	OR5BC_HUMAN	olfactory receptor, family 5, subfamily B, member 12	60					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(6)|liver(1)|lung(28)|ovary(1)|prostate(3)|skin(1)	40	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				GGTTACTGAGGAAGAAGTACA	0.458000													18	39					0	0	1	0	0
ABCC5	10057	broad.mit.edu	37	3	183695342	183695342	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:183695342G>A	ENST00000334444.6	-	10	1607	c.1367C>T	c.(1366-1368)tCc>tTc	p.S456F	ABCC5_ENST00000265586.6_Missense_Mutation_p.S456F|ABCC5_ENST00000492216.1_5'UTR	NM_005688.2	NP_005679.2	O15440	MRP5_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	456	ABC transmembrane type-1 1.					integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	62	all_cancers(143;1.85e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TTCTGAGAGGGACTTTACTGA	0.488000													22	38					0	0	1	0	0
FBXL20	84961	broad.mit.edu	37	17	37420601	37420601	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:37420601G>A	ENST00000264658.6	-	14	1290	c.1030C>T	c.(1030-1032)Cgt>Tgt	p.R344C	FBXL20_ENST00000583610.1_Missense_Mutation_p.R344C|FBXL20_ENST00000577399.1_Missense_Mutation_p.R346C|FBXL20_ENST00000394294.3_Missense_Mutation_p.R312C	NM_032875.2	NP_116264.2	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20	344						cytoplasm				breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	22			LUAD - Lung adenocarcinoma(14;0.146)			CCCAGGTGACGAATTCCATCA	0.517000													21	36					0	0	1	0	0
CAPSL	133690	broad.mit.edu	37	5	35921187	35921187	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:35921187C>T	ENST00000397367.2	-	2	162	c.36G>A	c.(34-36)gcG>gcA	p.A12A	CAPSL_ENST00000514524.1_Silent_p.A12A|CAPSL_ENST00000397366.1_Silent_p.A12A	NM_144647.3	NP_653248.3	Q8WWF8	CAPSL_HUMAN	calcyphosine-like	12						cytoplasm	calcium ion binding			central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(10)|skin(1)|urinary_tract(1)	19	all_lung(31;0.000268)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.167)|Colorectal(62;0.202)			TGGCCTGGATCGCCATCTCTC	0.612000													13	74					0	0	1	0	0
IGHG1	3500	broad.mit.edu	37	14	106208531	106208531	+	RNA	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:106208531G>T	ENST00000390548.2	-	0	368																											GGAAGAGGAAGACTGACGGTC	0.622000													68	19					1.08241e-25	1.09778e-25	1	1	0
DSP	1832	broad.mit.edu	37	6	7558354	7558354	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:7558354G>A	ENST00000379802.3	+	3	620	c.279G>A	c.(277-279)ttG>ttA	p.L93L	DSP_ENST00000418664.2_Silent_p.L93L	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	93	Globular 1.|Interacts with plakophilin 1 and junction plakoglobin.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TTCAGGAATTGAAGTATGGAG	0.428000													20	58					0	0	1	0	0
MAGEA6	4105	broad.mit.edu	37	X	151869890	151869890	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:151869890C>T	ENST00000329342.5	+	3	805	c.580C>T	c.(580-582)Cag>Tag	p.Q194*		NM_005363.2	NP_005354.1	P43360	MAGA6_HUMAN	melanoma antigen family A, 6	194	MAGE.						protein binding			breast(1)|endometrium(3)|large_intestine(3)|lung(16)|prostate(3)|skin(1)|urinary_tract(1)	28	Acute lymphoblastic leukemia(192;6.56e-05)					GGGTGACAATCAGATCATGCC	0.557000													73	11					0	0	1	0	0
OR2G3	81469	broad.mit.edu	37	1	247768908	247768908	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:247768908T>G	ENST00000320002.2	+	1	53	c.21T>G	c.(19-21)agT>agG	p.S7R	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	7					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GCAATGAGAGTTCCCTAATGG	0.463000													58	11					0	0	1	0	0
EYA2	2139	broad.mit.edu	37	20	45808505	45808505	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:45808505C>T	ENST00000327619.5	+	13	1632	c.1258C>T	c.(1258-1260)Ctc>Ttc	p.L420F	EYA2_ENST00000317304.6_Missense_Mutation_p.L390F|EYA2_ENST00000357410.3_Intron	NM_005244.4	NP_005235.3	O00167	EYA2_HUMAN	eyes absent homolog 2 (Drosophila)	420					DNA repair|histone dephosphorylation|mesodermal cell fate specification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	magnesium ion binding|protein binding|protein tyrosine phosphatase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0241)				GCTGGAAGCTCTCACAGACCT	0.517000													12	34					0	0	1	0	0
SMARCC2	6601	broad.mit.edu	37	12	56561889	56561889	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:56561889C>T	ENST00000394023.3	-	26	2910	c.2805G>A	c.(2803-2805)cgG>cgA	p.R935R	SMARCC2_ENST00000550164.1_Silent_p.R935R|SMARCC2_ENST00000267064.4_Silent_p.R904R|SMARCC2_ENST00000347471.4_Silent_p.R935R|RP11-977G19.5_ENST00000553176.1_RNA	NM_001130420.1	NP_001123892.1	Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	904					chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			CCTCAAAGTGCCGAAGTTTGA	0.527000													17	73					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181725162	181725162	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:181725162C>T	ENST00000526775.1	+	28	4168	c.4003C>T	c.(4003-4005)Cac>Tac	p.H1335Y	CACNA1E_ENST00000357570.5_Missense_Mutation_p.H1305Y|CACNA1E_ENST00000367573.2_Missense_Mutation_p.H1354Y|CACNA1E_ENST00000360108.3_Missense_Mutation_p.H1335Y|CACNA1E_ENST00000367567.4_Missense_Mutation_p.H961Y|CACNA1E_ENST00000358338.5_Missense_Mutation_p.H1286Y|CACNA1E_ENST00000367570.1_Missense_Mutation_p.H1354Y	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1354					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CCATGAATTCCACTACGACAA	0.502000													9	30					0	0	1	0	0
ATP7A	538	broad.mit.edu	37	X	77244168	77244168	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:77244168C>T	ENST00000341514.6	+	3	706	c.551C>T	c.(550-552)tCa>tTa	p.S184L	ATP7A_ENST00000350425.4_Intron|ATP7A_ENST00000343533.5_Missense_Mutation_p.S184L	NM_000052.5	NP_000043.3	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	184	HMA 2.				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						ACCTGCCATTCATGTACTAGC	0.433000													98	19					0	0	1	0	0
LRRC37A3	374819	broad.mit.edu	37	17	62865265	62865265	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:62865265G>A	ENST00000584306.1	-	8	3456	c.2926C>T	c.(2926-2928)Ctg>Ttg	p.L976L	LRRC37A3_ENST00000339474.5_Silent_p.L94L|LRRC37A3_ENST00000319651.5_Silent_p.L976L|LRRC37A3_ENST00000400877.3_Silent_p.L14L	NM_199340.2	NP_955372.2	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	976						integral to membrane				NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|liver(1)|lung(10)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						ACAGTTGTCAGAGGATTGTGA	0.299000													40	61					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56817587	56817587	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:56817587G>A	ENST00000229201.4	-	16	2111	c.1957C>T	c.(1957-1959)Ctt>Ttt	p.L653F	TIMELESS_ENST00000553532.1_Missense_Mutation_p.L654F|TIMELESS_ENST00000554616.1_Intron	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	654					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						TCACGGGGAAGTGGAGCAGAG	0.507000													30	52					0	0	1	0	0
LIN7A	8825	broad.mit.edu	37	12	81283110	81283110	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:81283110C>T	ENST00000552864.1	-	2	323	c.121G>A	c.(121-123)Gaa>Aaa	p.E41K		NM_004664.2	NP_004655.1	O14910	LIN7A_HUMAN	lin-7 homolog A (C. elegans)	41	L27.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(2)	15						TCTCCAGATTCCTGTAGTTTT	0.348000													3	19					0	0	1	0	0
SCG3	29106	broad.mit.edu	37	15	51981545	51981545	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:51981545G>A	ENST00000220478.3	+	6	1073	c.670G>A	c.(670-672)Gga>Aga	p.G224R	SCG3_ENST00000542355.2_5'UTR	NM_013243.3	NP_037375.2	Q8WXD2	SCG3_HUMAN	secretogranin III	224					platelet activation|platelet degranulation	extracellular region|stored secretory granule				breast(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21				all cancers(107;0.00488)		GAATCAGGCTGGAAAAATACC	0.403000													15	12					0	0	1	0	0
JADE1	79960	broad.mit.edu	37	4	129783124	129783124	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:129783124G>A	ENST00000226319.6	+	9	1527	c.1247G>A	c.(1246-1248)cGt>cAt	p.R416H	PHF17_ENST00000413543.2_Missense_Mutation_p.R416H|PHF17_ENST00000512960.1_Missense_Mutation_p.R416H|PHF17_ENST00000452328.2_Missense_Mutation_p.R404H|PHF17_ENST00000511647.1_Missense_Mutation_p.R416H	NM_199320.2	NP_955352.1	Q6IE81	JADE1_HUMAN		416					apoptosis|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell growth|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	histone acetyltransferase complex|mitochondrion	protein binding|zinc ion binding			NS(1)|breast(2)|endometrium(1)|kidney(2)|large_intestine(10)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GTGAGTGTCCGTAAGCAGAAG	0.607000													4	129					0	0	1	0	0
PRR22	163154	broad.mit.edu	37	19	5783899	5783899	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:5783899G>A	ENST00000419421.2	-	3	463	c.359C>T	c.(358-360)cCc>cTc	p.P120L		NM_001134316.1	NP_001127788.1	Q8IZ63	PRR22_HUMAN	proline rich 22	118	Pro-rich.									endometrium(2)|large_intestine(1)|prostate(1)|urinary_tract(1)	5						CTTGAGGTAGGGCTGAGGCTC	0.716000													3	6					0	0	1	0	0
APP	351	broad.mit.edu	37	21	27284167	27284167	+	Missense_Mutation	SNP	C	C	T	rs140304729		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:27284167C>T	ENST00000358918.3	-	14	1994	c.1795G>A	c.(1795-1797)Gaa>Aaa	p.E599K	APP_ENST00000448388.2_Missense_Mutation_p.E489K|APP_ENST00000439274.2_Missense_Mutation_p.E543K|APP_ENST00000440126.3_Missense_Mutation_p.E575K|APP_ENST00000348990.5_Missense_Mutation_p.E524K|APP_ENST00000346798.3_Missense_Mutation_p.E599K|APP_ENST00000359726.3_Missense_Mutation_p.E543K|APP_ENST00000354192.3_Missense_Mutation_p.E468K|APP_ENST00000357903.3_Missense_Mutation_p.E580K	NM_001204301.1|NM_001204302.1	NP_001191230.1|NP_001191231.1	P05067	A4_HUMAN	amyloid beta (A4) precursor protein	599					adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			endometrium(5)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	22		Breast(209;0.00295)				GTTTTCGTTTCGGTCAAAGAT	0.502000													11	35					0	0	1	0	0
TMEM156	80008	broad.mit.edu	37	4	39000389	39000389	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:39000389G>A	ENST00000381938.3	-	2	336	c.229C>T	c.(229-231)Ccc>Tcc	p.P77S	TMEM156_ENST00000372489.2_5'UTR	NM_024943.1	NP_079219.1	Q8N614	TM156_HUMAN	transmembrane protein 156	77						integral to membrane				endometrium(1)|large_intestine(3)|lung(3)|ovary(1)|skin(1)|stomach(1)	10						AAATTGGAGGGATTTAGAAAG	0.368000													20	9					0	0	1	0	0
FRMPD3	84443	broad.mit.edu	37	X	106845425	106845425	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:106845425C>T	ENST00000276185.4	+	16	4255	c.4255C>T	c.(4255-4257)Ccc>Tcc	p.P1419S				Q5JV73	FRPD3_HUMAN	FERM and PDZ domain containing 3	1419						cytoskeleton				breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(16)|ovary(2)|urinary_tract(1)	28						TCTGGGAGCTCCCAATTACAG	0.617000													45	11					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28926124	28926124	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:28926124G>A	ENST00000257192.4	+	14	2275	c.2063G>A	c.(2062-2064)gGt>gAt	p.G688D	RP11-534N16.1_ENST00000581856.1_RNA|DSG1_ENST00000462981.2_Missense_Mutation_p.G47D|RP11-534N16.1_ENST00000578119.1_RNA	NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	688					calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AGAGAAGGAGGTCTGAATATG	0.428000													21	70					0	0	1	0	0
COX10-AS1	100874058	broad.mit.edu	37	17	13972805	13972805	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:13972805G>A	ENST00000602743.1	-	0	7																											CCGCCCGCCGGAAGTGGCGGC	0.687000													4	6					0	0	1	0	0
LTN1	26046	broad.mit.edu	37	21	30318484	30318484	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:30318484G>A	ENST00000361371.4	-	20	3763	c.3613C>T	c.(3613-3615)Ctt>Ttt	p.L1205F	LTN1_ENST00000389194.2_Missense_Mutation_p.L1251F	NM_015565.2	NP_056380.2	O94822	LTN1_HUMAN	listerin E3 ubiquitin protein ligase 1	1205							ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(12)|lung(19)|ovary(5)|pancreas(1)|prostate(2)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)	60						CAACTGAAAAGAAAAATATCT	0.303000													18	46					0	0	1	0	0
FBN1	2200	broad.mit.edu	37	15	48766501	48766501	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:48766501G>A	ENST00000316623.5	-	34	4616	c.4161C>T	c.(4159-4161)taC>taT	p.Y1387Y		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1387	EGF-like 23; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		ACAGACAGCGGTAAGATCCCA	0.448000													6	16					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9068671	9068671	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:9068671G>A	ENST00000397910.4	-	3	18978	c.18775C>T	c.(18775-18777)Ctg>Ttg	p.L6259L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6261	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						ATCTTCGCCAGTGTAGGGGTG	0.483000													30	56					0	0	1	0	0
AIM2	9447	broad.mit.edu	37	1	159043086	159043086	+	Silent	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:159043086A>T	ENST00000368130.4	-	2	492	c.204T>A	c.(202-204)atT>atA	p.I68I		NM_004833.1	NP_004824.1	O14862	AIM2_HUMAN	absent in melanoma 2	68	DAPIN.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				breast(1)|large_intestine(1)|lung(7)|ovary(2)|pancreas(2)|prostate(2)|skin(1)	16	all_hematologic(112;0.0429)					ACTTCTGAAAAATACGAATGG	0.448000													37	22					0	0	1	0	0
LOC728715	728715	broad.mit.edu	37	12	9717743	9717743	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:9717743C>T	ENST00000520314.1	+	0	4172																											AATTTCCATCCTTTATTCCCT	0.418000													8	2					0	0	1	0	0
TRIM71	131405	broad.mit.edu	37	3	32933207	32933207	+	Silent	SNP	C	C	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:32933207C>G	ENST00000383763.4	+	4	2574	c.2511C>G	c.(2509-2511)ggC>ggG	p.G837G		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase	837					multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						AAGGCAGCGGCTTTGGGCAGA	0.552000													70	99					0	0	1	0	0
NOS1	4842	broad.mit.edu	37	12	117723978	117723978	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:117723978G>A	ENST00000317775.6	-	6	1906	c.1221C>T	c.(1219-1221)atC>atT	p.I407I	NOS1_ENST00000338101.4_Silent_p.I407I|NOS1_ENST00000344089.3_3'UTR	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	407					multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	TGGCCCCATAGATGAGCTCTG	0.552000													25	21					0	0	1	0	0
RCN3	57333	broad.mit.edu	37	19	50031886	50031886	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:50031886C>T	ENST00000270645.3	+	2	604	c.157C>T	c.(157-159)Cag>Tag	p.Q53*	RCN3_ENST00000593644.1_3'UTR	NM_020650.2	NP_065701.2	Q96D15	RCN3_HUMAN	reticulocalbin 3, EF-hand calcium binding domain	53						endoplasmic reticulum lumen	calcium ion binding|protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.0966)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0159)		CGGGAACTTCCAGTACGACCA	0.642000													47	55					0	0	1	0	0
ZNF99	7652	broad.mit.edu	37	19	22951111	22951111	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:22951111G>A	ENST00000397104.3	-	3	284	c.285C>T	c.(283-285)ccC>ccT	p.P95P	ZNF99_ENST00000596209.1_Silent_p.P74P					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ACATACCTGGGGGTTTAGTTA	0.433000													7	16					0	0	1	0	0
ANKHD1	54882	broad.mit.edu	37	5	139838840	139838840	+	Silent	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:139838840T>C	ENST00000297183.6	+	9	1696	c.1572T>C	c.(1570-1572)ctT>ctC	p.L524L	ANKHD1_ENST00000394722.3_Silent_p.L513L|ANKHD1_ENST00000360839.2_Silent_p.L524L|ANKHD1_ENST00000394723.3_Silent_p.L524L|ANKHD1-EIF4EBP3_ENST00000532219.1_Silent_p.L524L	NM_020690.5	NP_065741.3			ankyrin repeat and KH domain containing 1											breast(2)|endometrium(8)|kidney(6)|large_intestine(14)|lung(18)|ovary(5)|prostate(2)|skin(3)|urinary_tract(2)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGACTTTCTTATTAAGGCAG	0.448000													18	36					0	0	1	0	0
ZNF609	23060	broad.mit.edu	37	15	64791923	64791923	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:64791923C>T	ENST00000326648.3	+	1	433	c.305C>T	c.(304-306)cCc>cTc	p.P102L	ZNF609_ENST00000416172.1_Missense_Mutation_p.P102L	NM_015042.1	NP_055857.1	O15014	ZN609_HUMAN	zinc finger protein 609	102						nucleus	zinc ion binding			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(9)|lung(11)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						ACTAGCAAACCCACTCCAGGG	0.537000													17	41					0	0	1	0	0
OR6B2	389090	broad.mit.edu	37	2	240969247	240969247	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:240969247G>A	ENST00000402971.2	-	1	659	c.600C>T	c.(598-600)ttC>ttT	p.F200F		NM_001005853.1	NP_001005853.1	Q6IFH4	OR6B2_HUMAN	olfactory receptor, family 6, subfamily B, member 2	200					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(4)|lung(9)|prostate(1)	15		all_epithelial(40;1.64e-11)|Breast(86;0.000327)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.4e-29)|all cancers(36;2.08e-27)|OV - Ovarian serous cystadenocarcinoma(60;4.63e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.56e-05)|Lung(119;0.00344)|LUSC - Lung squamous cell carcinoma(224;0.0148)		AGGCCAGGATGAAATCCACCA	0.572000													27	23					0	0	1	0	0
SLC10A3	8273	broad.mit.edu	37	X	153716274	153716274	+	Missense_Mutation	SNP	C	C	A	rs144362624		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:153716274C>A	ENST00000263512.4	-	2	1504	c.1006G>T	c.(1006-1008)Gtg>Ttg	p.V336L	SLC10A3_ENST00000369649.4_Missense_Mutation_p.V307L|SLC10A3_ENST00000393587.4_Missense_Mutation_p.V336L|SLC10A3_ENST00000393586.1_Missense_Mutation_p.V391L	NM_019848.3	NP_062822.1	P09131	P3_HUMAN	solute carrier family 10, member 3	336					organic anion transport	integral to membrane	bile acid:sodium symporter activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					AGCACGCCCACGGCTATGGGG	0.607000													34	13					4.74835e-14	4.80088e-14	1	1	0
OR8S1	341568	broad.mit.edu	37	12	48920255	48920255	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:48920255C>T	ENST00000310194.1	+	1	841	c.841C>T	c.(841-843)Ccc>Tcc	p.P281S	OR8S1_ENST00000551654.1_Intron	NM_001005203.2	NP_001005203.2	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S, member 1	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|skin(4)	22						TGTAGTCACTCCCATGCTGAA	0.423000													8	40					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179666924	179666924	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179666924G>A	ENST00000589042.1	-	3	460	c.236C>T	c.(235-237)tCc>tTc	p.S79F	TTN_ENST00000342992.6_Missense_Mutation_p.S79F|TTN_ENST00000591111.1_Missense_Mutation_p.S79F|TTN_ENST00000360870.5_Missense_Mutation_p.S79F|TTN_ENST00000460472.2_Missense_Mutation_p.S79F|TTN_ENST00000342175.6_Missense_Mutation_p.S79F|TTN_ENST00000359218.5_Missense_Mutation_p.S79F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	79	Ig-like 1.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGCTTTCAGGGAATATCGTCC	0.562000													45	84					0	0	1	0	0
HTR3C	170572	broad.mit.edu	37	3	183777667	183777667	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:183777667C>T	ENST00000318351.1	+	8	1011	c.977C>T	c.(976-978)aCc>aTc	p.T326I		NM_130770.2	NP_570126.2	Q8WXA8	5HT3C_HUMAN	5-hydroxytryptamine (serotonin) receptor 3C, ionotropic	326						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(2)	32	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;1.74e-35)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			CTGCTGGAGACCGTCTTCATT	0.567000													35	60					0	0	1	0	0
ESAM	90952	broad.mit.edu	37	11	124626244	124626244	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:124626244G>A	ENST00000278927.5	-	4	595	c.466C>T	c.(466-468)Cca>Tca	p.P156S	ESAM_ENST00000442070.2_Intron	NM_138961.2	NP_620411.2	Q96AP7	ESAM_HUMAN	endothelial cell adhesion molecule	156	Ig-like C2-type.				blood coagulation|leukocyte migration	adherens junction|integral to membrane|tight junction				endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.022)		CGGCAGGATGGAGGAGCTGGA	0.597000													6	10					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70986510	70986510	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:70986510G>A	ENST00000393567.2	-	41	6495	c.6345C>T	c.(6343-6345)gtC>gtT	p.V2115V		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	2115										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CTTGCCCTATGACGTTTTGAC	0.488000													7	18					0	0	1	0	0
SLC25A18	83733	broad.mit.edu	37	22	18065388	18065388	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:18065388G>A	ENST00000327451.5	+	6	797	c.259G>A	c.(259-261)Gac>Aac	p.D87N	AC004019.13_ENST00000443935.1_RNA|SLC25A18_ENST00000497401.1_3'UTR|SLC25A18_ENST00000399813.1_Missense_Mutation_p.D87N	NM_031481.1	NP_113669.1	Q9H1K4	GHC2_HUMAN	solute carrier family 25 (glutamate carrier), member 18	87						integral to membrane|mitochondrial inner membrane	binding|symporter activity			breast(4)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)	18				Lung(27;0.124)	L-Glutamic Acid(DB00142)	GGCGGCCAACGACTTTTTCCG	0.562000													8	4					0	0	1	0	0
FAM86C2P	645332	broad.mit.edu	37	11	67560710	67560710	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:67560710G>A	ENST00000528089.1	-	0	1040																											CTCTTCGTAGGGAAACAGTTT	0.512000													48	102					0	0	1	0	0
AK7	122481	broad.mit.edu	37	14	96924450	96924450	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:96924450G>A	ENST00000267584.4	+	12	1302	c.1258G>A	c.(1258-1260)Gaa>Aaa	p.E420K		NM_152327.3	NP_689540.2	Q96M32	KAD7_HUMAN	adenylate kinase 7	420	Adenylate kinase.|Poly-Glu.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			breast(2)|cervix(2)|endometrium(3)|large_intestine(8)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	31		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		CGATGTaggggaaggagaaga	0.502000													20	7					0	0	1	0	0
NUAK1	9891	broad.mit.edu	37	12	106460688	106460688	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:106460688C>T	ENST00000261402.2	-	7	3257	c.1878G>A	c.(1876-1878)aaG>aaA	p.K626K		NM_014840.2	NP_055655.1	O60285	NUAK1_HUMAN	NUAK family, SNF1-like kinase, 1	626							ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37						TCCGGTACCGCTTCAGGTACT	0.612000													32	29					0	0	1	0	0
JAK3	3718	broad.mit.edu	37	19	17950420	17950420	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:17950420C>T	ENST00000458235.1	-	10	1406	c.1307G>A	c.(1306-1308)gGa>gAa	p.G436E	JAK3_ENST00000526008.1_5'UTR|JAK3_ENST00000527670.1_Missense_Mutation_p.G436E|JAK3_ENST00000534444.1_Missense_Mutation_p.G436E	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	436	SH2; atypical.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						AAGGAAGGTTCCTGTGGGGCT	0.617000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								5	9					0	0	1	0	0
FHDC1	85462	broad.mit.edu	37	4	153897222	153897222	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:153897222C>T	ENST00000511601.1	+	12	2967	c.2779C>T	c.(2779-2781)Ccc>Tcc	p.P927S	FHDC1_ENST00000260008.3_Missense_Mutation_p.P927S			Q9C0D6	FHDC1_HUMAN	FH2 domain containing 1	927					actin cytoskeleton organization		actin binding		ARFIP1/FHDC1(2)	NS(2)|breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|liver(2)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	43	all_hematologic(180;0.093)					ATCCCGGGGGCCCTCCCAGAA	0.672000													9	60					0	0	1	0	0
FAM45A	404636	broad.mit.edu	37	10	120877127	120877127	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:120877127C>T	ENST00000361432.2	+	4	455	c.429C>T	c.(427-429)ttC>ttT	p.F143F	FAM45A_ENST00000535029.1_Silent_p.F143F|FAM45A_ENST00000489988.1_3'UTR|FAM45A_ENST00000544016.1_Intron	NM_207009.2	NP_996892.1	Q8TCE6	FA45A_HUMAN	family with sequence similarity 45, member A	143										breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(2)|urinary_tract(1)	14		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.0293)		ACGGCTCTTTCCTTAGTAAGG	0.473000													4	52					0	0	1	0	0
TLL1	7092	broad.mit.edu	37	4	166976293	166976293	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:166976293C>T	ENST00000061240.2	+	13	2237	c.1590C>T	c.(1588-1590)agC>agT	p.S530S	TLL1_ENST00000507499.1_Silent_p.S553S	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	530	CUB 2.				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GTGAAAATAGCCCTTTGATAG	0.368000													45	31					0	0	1	0	0
NPHS2	7827	broad.mit.edu	37	1	179533877	179533877	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:179533877G>A	ENST00000367615.4	-	2	394	c.326C>T	c.(325-327)tCc>tTc	p.S109F	NPHS2_ENST00000367616.4_Missense_Mutation_p.S109F	NM_014625.2	NP_055440.1	Q9NP85	PODO_HUMAN	nephrosis 2, idiopathic, steroid-resistant (podocin)	109					excretion	integral to plasma membrane	protein binding	p.S109F(1)		NS(1)|endometrium(1)|large_intestine(3)|lung(10)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	20						GAAGAGCAGGGAAATGAGGAC	0.413000													54	8					0	0	1	0	0
TMEM67	91147	broad.mit.edu	37	8	94777836	94777836	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:94777836C>T	ENST00000453321.3	+	6	671	c.613C>T	c.(613-615)Cct>Tct	p.P205S	TMEM67_ENST00000409623.3_Missense_Mutation_p.P124S	NM_153704.5	NP_714915.3	Q5HYA8	MKS3_HUMAN	transmembrane protein 67	205					cilium assembly|ER-associated protein catabolic process|negative regulation of centrosome duplication	centrosome|cilium membrane|cytoplasmic vesicle membrane|endoplasmic reticulum membrane|integral to membrane|microtubule basal body	unfolded protein binding	p.P195S(1)		breast(3)|endometrium(8)|kidney(5)|large_intestine(4)|liver(2)|lung(15)|ovary(2)|skin(1)|urinary_tract(1)	41	Breast(36;4.14e-07)		BRCA - Breast invasive adenocarcinoma(8;0.00896)			AGGGAATTTTCCTCTACGTAG	0.328000													14	23					0	0	1	0	0
RASGEF1B	153020	broad.mit.edu	37	4	82377913	82377913	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:82377913G>A	ENST00000436139.2	-	4	456	c.330C>T	c.(328-330)atC>atT	p.I110I	RASGEF1B_ENST00000514889.1_5'UTR|RASGEF1B_ENST00000335927.7_Silent_p.I69I|RASGEF1B_ENST00000264400.2_Silent_p.I110I|RASGEF1B_ENST00000509081.1_Silent_p.I110I			Q0VAM2	RGF1B_HUMAN	RasGEF domain family, member 1B	110	N-terminal Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			endometrium(2)|kidney(5)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	26						GGAGTTGAAGGATTTTGGGTG	0.373000													32	20					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615370	179615370	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179615370G>A	ENST00000360870.5	-	46	11979	c.11757C>T	c.(11755-11757)ttC>ttT	p.F3919F	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9739				P -> L (in Ref. 1; CAA62188).			ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTTCGGTTTTGAATTCATCAA	0.333000													10	20					0	0	1	0	0
SORCS1	114815	broad.mit.edu	37	10	108389027	108389027	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:108389027G>A	ENST00000263054.6	-	19	2602	c.2595C>T	c.(2593-2595)ttC>ttT	p.F865F	SORCS1_ENST00000344440.6_Silent_p.F865F|SORCS1_ENST00000369698.1_Silent_p.F400F	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	865	PKD.					integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CGGTCACACGGAAAATGCCCA	0.473000													11	5					0	0	1	0	0
GJB5	2709	broad.mit.edu	37	1	35223256	35223256	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:35223256C>T	ENST00000338513.1	+	2	498	c.325C>T	c.(325-327)Cat>Tat	p.H109Y		NM_005268.3	NP_005259.1	O95377	CXB5_HUMAN	gap junction protein, beta 5, 31.1kDa	109					cell communication|epidermis development	connexon complex|integral to membrane				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(1)	10		Myeloproliferative disorder(586;0.0393)				CCGAGAAGCCCATGGGGAGAA	0.622000													93	47					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41561058	41561058	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:41561058C>T	ENST00000400454.1	-	12	2941	c.2464G>A	c.(2464-2466)Gag>Aag	p.E822K		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	822	Ig-like C2-type 9.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TCCTCCTTCTCCCAGCGGACT	0.512000													44	63					0	0	1	0	0
TRPV6	55503	broad.mit.edu	37	7	142574588	142574588	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:142574588C>T	ENST00000359396.3	-	5	735	c.490G>A	c.(490-492)Gag>Aag	p.E164K	RP11-114L10.2_ENST00000438839.1_RNA	NM_018646.3	NP_061116.2	Q9H1D0	TRPV6_HUMAN	transient receptor potential cation channel, subfamily V, member 6	164					regulation of calcium ion-dependent exocytosis	integral to plasma membrane	calcium channel activity|calmodulin binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(15)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	42	Melanoma(164;0.059)					AAAGGGTGCTCCCCTGTGGAC	0.572000													10	27					0	0	1	0	0
FCRL1	115350	broad.mit.edu	37	1	157767670	157767670	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:157767670C>T	ENST00000368176.3	-	9	1241	c.1174G>A	c.(1174-1176)Gaa>Aaa	p.E392K	FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000491942.1_Missense_Mutation_p.E392K|FCRL1_ENST00000358292.3_Intron	NM_001159398.1|NM_052938.4	NP_001152870.1|NP_443170.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	392						integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			GCTACTGATTCCTGCTCCGGC	0.483000													39	19					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27326180	27326180	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:27326180G>A	ENST00000429845.2	-	23	2289	c.1927C>T	c.(1927-1929)Cga>Tga	p.R643*	NEK10_ENST00000341435.5_Nonsense_Mutation_p.R643*|NEK10_ENST00000357467.2_Nonsense_Mutation_p.R40*			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	643	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R643*(1)		NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						TGTAAGTATCGAAGAGCTAAG	0.373000													23	28					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20959876	20959876	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:20959876C>T	ENST00000261383.3	-	57	11271	c.11272G>A	c.(11272-11274)Gaa>Aaa	p.E3758K	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3758					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TCCTCAATTTCCTTACAGTAG	0.532000													46	3					0	0	1	0	0
ZNF180	7733	broad.mit.edu	37	19	45004265	45004265	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:45004265C>T	ENST00000221327.4	-	1	309	c.28G>A	c.(28-30)Gaa>Aaa	p.E10K	ZNF180_ENST00000587047.1_Missense_Mutation_p.E10K|ZNF180_ENST00000391956.4_Missense_Mutation_p.E10K|ZNF180_ENST00000586637.1_Intron|ZNF180_ENST00000585514.1_5'UTR|ZNF180_ENST00000592529.1_Intron	NM_013256.3	NP_037388.2	Q9UJW8	ZN180_HUMAN	zinc finger protein 180	10					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(14)|lung(6)|ovary(2)|urinary_tract(1)	33		Prostate(69;0.0435)				CTTCCAGCTTCCCGCGTAGAC	0.667000											OREG0025537	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	57	163					0	0	1	0	0
TAS2R60	338398	broad.mit.edu	37	7	143140827	143140827	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:143140827G>A	ENST00000332690.1	+	1	282	c.282G>A	c.(280-282)caG>caA	p.Q94Q	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	94					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					CTGTACTGCAGTTTCTAGCTT	0.498000													48	78					0	0	1	0	0
SERPINB13	5275	broad.mit.edu	37	18	61262319	61262319	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:61262319C>T	ENST00000344731.5	+	7	774	c.672C>T	c.(670-672)ttC>ttT	p.F224F	SERPINB13_ENST00000269489.5_Intron	NM_012397.3	NP_036529.1	Q9UIV8	SPB13_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 13	224					regulation of proteolysis|response to UV	cytoplasm|extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|prostate(2)|urinary_tract(1)	25						GCTTCACTTTCCTGGAGGACT	0.433000													25	55					0	0	1	0	0
ANGPTL2	23452	broad.mit.edu	37	9	129870846	129870846	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:129870846G>A	ENST00000373425.3	-	2	782	c.165C>T	c.(163-165)acC>acT	p.T55T	RALGPS1_ENST00000424082.2_Intron|RALGPS1_ENST00000394022.3_Intron|RALGPS1_ENST00000373434.1_Intron|RALGPS1_ENST00000373436.1_Intron|ANGPTL2_ENST00000373417.1_Intron|RALGPS1_ENST00000259351.5_Intron	NM_012098.2	NP_036230.1	Q9UKU9	ANGL2_HUMAN	angiopoietin-like 2	55					multicellular organismal development|signal transduction	extracellular space	receptor binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|urinary_tract(1)	18						TGAAGGTGTAGGTGCACTTGT	0.592000													26	6					0	0	1	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29973937	29973937	+	Nonstop_Mutation	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:29973937A>G	ENST00000378993.1	+	11	2764	c.2091A>G	c.(2089-2091)tgA>tgG	p.*697W	IL1RAPL1_ENST00000302196.4_Nonstop_Mutation_p.*697W	NM_014271.3	NP_055086.1	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	0					innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						TGATATGGTGACAGAAAAGCA	0.512000													15	2					0	0	1	0	0
CORO2B	10391	broad.mit.edu	37	15	68987559	68987559	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:68987559C>T	ENST00000543950.1	+	3	636	c.282C>T	c.(280-282)atC>atT	p.I94I	CORO2B_ENST00000261861.5_Silent_p.I94I|CORO2B_ENST00000540068.1_Silent_p.I94I|CORO2B_ENST00000566799.1_Silent_p.I99I	NM_001190457.1	NP_001177386.1	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	99					actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			kidney(3)|large_intestine(13)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						ACCCCTTCATCGACAACATCA	0.597000													14	50					0	0	1	0	0
OR2T34	127068	broad.mit.edu	37	1	248737766	248737766	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:248737766G>A	ENST00000328782.2	-	1	314	c.293C>T	c.(292-294)tCc>tTc	p.S98F		NM_001001821.1	NP_001001821.1	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T, member 34	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(6)|lung(28)|ovary(2)|skin(2)|stomach(3)	43	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GCCTGACGGGGAAATGGTATC	0.547000													48	24					0	0	1	0	0
PPP1R11	6992	broad.mit.edu	37	6	30036912	30036912	+	Silent	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:30036912T>C	ENST00000376772.3	+	3	533	c.210T>C	c.(208-210)ttT>ttC	p.F70F	PPP1R11_ENST00000376763.1_Silent_p.F18F|PPP1R11_ENST00000376765.2_Silent_p.F18F|PPP1R11_ENST00000376758.1_Silent_p.F18F|PPP1R11_ENST00000376769.2_Silent_p.F18F|PPP1R11_ENST00000376773.1_Silent_p.F18F	NM_021959.2	NP_068778.1	O60927	PP1RB_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 11	70						soluble fraction	protein binding|protein phosphatase inhibitor activity			lung(2)|ovary(1)|prostate(1)|skin(2)	6						CTCGGGCCTTTGGCGAGAGCT	0.522000													20	63					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196759830	196759830	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:196759830G>A	ENST00000312428.6	-	30	4866	c.4766C>T	c.(4765-4767)tCc>tTc	p.S1589F		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1589	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AATCTTCTCGGAAAAGAATGC	0.368000													14	24					0	0	1	0	0
IGKV1-27	28935	broad.mit.edu	37	2	89513063	89513063	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:89513063G>A	ENST00000498435.1	-	0	226																											AGGAGCTTAGGAACTTTCCCT	0.512000													56	92					0	0	1	0	0
ONECUT2	9480	broad.mit.edu	37	18	55104091	55104091	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:55104091C>T	ENST00000491143.2	+	1	1175	c.1143C>T	c.(1141-1143)ctC>ctT	p.L381L		NM_004852.2	NP_004843.2	O95948	ONEC2_HUMAN	one cut homeobox 2	381					organ morphogenesis	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(4)|ovary(2)|skin(1)	15		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		GGAGTAAACTCAAATCTGGCA	0.607000													13	29					0	0	1	0	0
LINGO3	645191	broad.mit.edu	37	19	2291207	2291207	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:2291207G>A	ENST00000585527.1	-	1	816	c.569C>T	c.(568-570)tCc>tTc	p.S190F	LINGO3_ENST00000404279.1_Missense_Mutation_p.S190F			P0C6S8	LIGO3_HUMAN	leucine rich repeat and Ig domain containing 3	190						integral to membrane				lung(1)|urinary_tract(1)	2						CGACTCCCCGGACAGAGCCGT	0.721000													11	9					0	0	1	0	0
TCP10L	140290	broad.mit.edu	37	21	33951122	33951122	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:33951122C>T	ENST00000300258.3	-	4	493	c.380G>A	c.(379-381)gGa>gAa	p.G127E	TCP10L_ENST00000491828.1_5'UTR	NM_144659.5	NP_653260.1			t-complex 10-like											breast(1)|central_nervous_system(1)|liver(1)|skin(1)	4						TGAAATTTTTCCAAAAGCAGG	0.373000													33	51					0	0	1	0	0
NCR2	9436	broad.mit.edu	37	6	41309751	41309751	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:41309751C>T	ENST00000373086.3	+	4	570	c.544C>T	c.(544-546)Ctt>Ttt	p.L182F	NCR2_ENST00000373089.5_Intron|NCR2_ENST00000373083.4_Intron	NM_001199509.1	NP_001186438.1	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	174					cellular defense response	integral to plasma membrane	transmembrane receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	14	Ovarian(28;0.0327)|Colorectal(47;0.196)					GTCCTCTCCCCTTCCTGTCCC	0.662000													23	101					0	0	1	0	0
EMILIN1	11117	broad.mit.edu	37	2	27302058	27302058	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:27302058G>A	ENST00000380320.4	+	1	624	c.125G>A	c.(124-126)gGg>gAg	p.G42E		NM_007046.3	NP_008977.1	Q9Y6C2	EMIL1_HUMAN	elastin microfibril interfacer 1	42					cell adhesion	collagen				breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(1)|lung(14)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	26	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCAGCCCCGGGGGGCCCCAG	0.682000													9	25					0	0	1	0	0
OR52B4	143496	broad.mit.edu	37	11	4389049	4389049	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:4389049G>A	ENST00000408920.2	-	1	567	c.477C>T	c.(475-477)ttC>ttT	p.F159F		NM_001005161.3	NP_001005161.2	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B, member 4	159					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(2)|kidney(3)|large_intestine(7)|lung(15)|skin(2)	31		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATATGATAGGGAAAATTGTAC	0.363000													19	22					0	0	1	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21457486	21457486	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:21457486G>A	ENST00000307378.6	-	7	1184	c.464C>T	c.(463-465)tCa>tTa	p.S155L	SLCO1A2_ENST00000458504.1_Missense_Mutation_p.S23L|SLCO1A2_ENST00000390670.3_Missense_Mutation_p.S153L|SLCO1A2_ENST00000537524.1_Missense_Mutation_p.S23L|SLCO1A2_ENST00000452078.1_Missense_Mutation_p.S155L	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	155					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						CCACATTAATGATTTAACTTC	0.353000													14	46					0	0	1	0	0
XKR7	343702	broad.mit.edu	37	20	30584802	30584802	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:30584802G>A	ENST00000217299.3	+	3	1456	c.1282G>A	c.(1282-1284)Ggc>Agc	p.G428S		NM_001011718.1	NP_001011718.1	Q5GH72	XKR7_HUMAN	XK, Kell blood group complex subunit-related family, member 7	428						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|liver(1)|lung(19)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	34			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			CTTTGCGCTGGGCATATTCTT	0.587000													41	98					0	0	1	0	0
ACOXL	55289	broad.mit.edu	37	2	111542359	111542359	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:111542359C>T	ENST00000389811.4	+	3	350	c.126C>T	c.(124-126)gtC>gtT	p.V42V	ACOXL_ENST00000439055.1_Silent_p.V42V|ACOXL_ENST00000340561.4_Silent_p.V42V			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	42					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						TAGGAGAAGTCCTCTCCATGG	0.478000													20	49					0	0	1	0	0
CERKL	375298	broad.mit.edu	37	2	182403989	182403989	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:182403989G>A	ENST00000410087.3	-	12	1468	c.1368C>T	c.(1366-1368)ttC>ttT	p.F456F	CERKL_ENST00000409440.3_Silent_p.F438F|CERKL_ENST00000374969.2_Silent_p.F343F|CERKL_ENST00000374970.2_Silent_p.F387F|CERKL_ENST00000339098.5_Silent_p.F482F	NM_001030311.2|NM_201548.4	NP_001025482.1|NP_963842.1	Q49MI3	CERKL_HUMAN	ceramide kinase-like	482					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis	endoplasmic reticulum|Golgi apparatus|nucleolus	diacylglycerol kinase activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(13)|ovary(3)|skin(3)	32			OV - Ovarian serous cystadenocarcinoma(117;0.088)			ATGGAAAATTGAACTAAAAAT	0.353000													19	19					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34092150	34092150	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:34092150C>T	ENST00000397527.1	+	30	6673	c.5953C>T	c.(5953-5955)Ctc>Ttc	p.L1985F	CEP250_ENST00000342580.4_Missense_Mutation_p.L1929F	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	1985	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GCAGCATCTCCTCGAGCAGGC	0.672000													5	9					0	0	1	0	0
STAM2	10254	broad.mit.edu	37	2	153000417	153000417	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:153000417A>T	ENST00000263904.4	-	7	977	c.628T>A	c.(628-630)Tta>Ata	p.L210I	STAM2_ENST00000465460.1_5'UTR	NM_005843.4	NP_005834.4	O75886	STAM2_HUMAN	signal transducing adaptor molecule (SH3 domain and ITAM motif) 2	210	SH3.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			endometrium(3)|large_intestine(4)|lung(8)|ovary(1)	16				BRCA - Breast invasive adenocarcinoma(221;0.22)		AAATCATATAAAGCTCTCACT	0.333000													23	23					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215824121	215824121	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:215824121C>T	ENST00000366943.2	-	65	14542	c.14156G>A	c.(14155-14157)gGa>gAa	p.G4719E	USH2A_ENST00000307340.3_Missense_Mutation_p.G4719E			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4719	Fibronectin type-III 32.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GGGGGCTTTTCCTGCAGAATT	0.488000										HNSCC(13;0.011)			104	47					0	0	1	0	0
KRTAP5-4	387267	broad.mit.edu	37	11	1643027	1643027	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:1643027C>T	ENST00000399682.1	-	1	341	c.297G>A	c.(295-297)ggG>ggA	p.G99G		NM_001012709.1	NP_001012727.1	Q6L8H1	KRA54_HUMAN	keratin associated protein 5-4	99	9 X 4 AA repeats of C-C-X-P.					keratin filament				NS(1)|endometrium(9)|kidney(2)|lung(2)|pancreas(1)|prostate(3)|skin(2)	20		all_epithelial(84;0.00819)|Breast(177;0.00832)|Ovarian(85;0.0256)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		AGCCACAGCCCCCCTTGGAAC	0.682000													11	191					0	0	1	0	0
PLIN4	729359	broad.mit.edu	37	19	4513695	4513695	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:4513695C>T	ENST00000301286.3	-	3	234	c.235G>A	c.(235-237)Gac>Aac	p.D79N		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	79						lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						CACACCAGGTCTTTGGCCCCG	0.622000													10	19					0	0	1	0	0
LINGO3	645191	broad.mit.edu	37	19	2291206	2291206	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:2291206G>A	ENST00000585527.1	-	1	817	c.570C>T	c.(568-570)tcC>tcT	p.S190S	LINGO3_ENST00000404279.1_Silent_p.S190S			P0C6S8	LIGO3_HUMAN	leucine rich repeat and Ig domain containing 3	190						integral to membrane				lung(1)|urinary_tract(1)	2						GCGACTCCCCGGACAGAGCCG	0.721000													11	9					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90452922	90452922	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:90452922G>A	ENST00000369393.3	-	31	4510	c.4395C>T	c.(4393-4395)ttC>ttT	p.F1465F	MDN1_ENST00000428876.1_Silent_p.F1465F			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1465					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		CATCCAAGAGGAAAAAGCCGT	0.448000													39	30					0	0	1	0	0
FDXACB1	91893	broad.mit.edu	37	11	111746136	111746136	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:111746136G>A	ENST00000260257.4	-	5	1432	c.1385C>T	c.(1384-1386)aCt>aTt	p.T462I	ALG9_ENST00000524880.1_Intron|ALG9_ENST00000527377.1_Intron|FDXACB1_ENST00000542429.1_Missense_Mutation_p.T313I	NM_138378.2	NP_612387.1	Q9BRP7	FDXA1_HUMAN	ferredoxin-fold anticodon binding domain containing 1	462					phenylalanyl-tRNA aminoacylation|tRNA processing		ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(3)	19						TAGATCCTCAGTACAATCTGG	0.373000													30	29					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	10274182	10274182	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:10274182C>T	ENST00000396573.2	-	3	396	c.87G>A	c.(85-87)aaG>aaA	p.K29K	GRIN2A_ENST00000562109.1_Silent_p.K29K|GRIN2A_ENST00000330684.3_Silent_p.K29K|GRIN2A_ENST00000396575.2_Silent_p.K29K|GRIN2A_ENST00000404927.2_Silent_p.K29K	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	29					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	CGGGGGGACCCTTCTCCGCCG	0.692000													29	41					0	0	1	0	0
IKZF3	22806	broad.mit.edu	37	17	37922178	37922178	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:37922178C>T	ENST00000346872.3	-	8	1456	c.1395G>A	c.(1393-1395)gtG>gtA	p.V465V	IKZF3_ENST00000439167.2_Silent_p.V392V|IKZF3_ENST00000439016.2_Silent_p.V370V|IKZF3_ENST00000377944.3_Silent_p.V322V|IKZF3_ENST00000467757.1_Silent_p.V409V|IKZF3_ENST00000535189.1_Silent_p.V431V|IKZF3_ENST00000394189.2_Silent_p.V283V|IKZF3_ENST00000377945.3_Silent_p.V331V|IKZF3_ENST00000377952.2_Silent_p.V244V|IKZF3_ENST00000377958.2_Silent_p.V378V|IKZF3_ENST00000351680.3_Silent_p.V426V|IKZF3_ENST00000350532.3_Silent_p.V426V|IKZF3_ENST00000346243.3_Silent_p.V387V|IKZF3_ENST00000583368.1_Silent_p.V218V	NM_012481.4	NP_036613.2	Q9UKT9	IKZF3_HUMAN	IKAROS family zinc finger 3 (Aiolos)	465					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(5)|kidney(6)|large_intestine(4)|liver(1)|lung(13)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			TCGTGAACATCACATAGTCCA	0.522000													41	91					0	0	1	0	0
COL11A1	1301	broad.mit.edu	37	1	103388895	103388895	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:103388895G>A	ENST00000358392.2	-	47	4004	c.3687C>T	c.(3685-3687)ccC>ccT	p.P1229P	COL11A1_ENST00000353414.4_Silent_p.P1178P|COL11A1_ENST00000512756.1_Silent_p.P1101P|COL11A1_ENST00000370096.3_Silent_p.P1217P	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1217	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		AACTTACCATGGGACCAACAT	0.338000													10	6					0	0	1	0	0
ALLC	55821	broad.mit.edu	37	2	3726132	3726132	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:3726132G>A	ENST00000252505.3	+	4	321	c.159G>A	c.(157-159)agG>agA	p.R53R		NM_018436.3	NP_060906.3	Q8N6M5	ALLC_HUMAN	allantoicase	72							allantoicase activity			breast(4)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	30	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.088)	all_cancers(51;0.24)		OV - Ovarian serous cystadenocarcinoma(76;0.088)|all cancers(51;0.151)|Epithelial(75;0.206)		AGACCAGGAGGAAAAGGATTC	0.493000										HNSCC(21;0.051)			7	31					0	0	1	0	0
DENND5A	23258	broad.mit.edu	37	11	9215151	9215151	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:9215151G>A	ENST00000328194.3	-	5	1347	c.1027C>T	c.(1027-1029)Cct>Tct	p.P343S	DENND5A_ENST00000530044.1_Missense_Mutation_p.P343S	NM_001243254.1|NM_015213.3	NP_001230183.1|NP_056028.2	Q6IQ26	DEN5A_HUMAN	DENN/MADD domain containing 5A	343	DENN.									breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(16)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GGGAGAATAGGGACATAGACA	0.478000													38	52					0	0	1	0	0
OR10S1	219873	broad.mit.edu	37	11	123848276	123848276	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:123848276G>A	ENST00000531945.1	-	1	212	c.123C>T	c.(121-123)ttC>ttT	p.F41F		NM_001004474.1	NP_001004474.1	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S, member 1	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	36		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		GGAAGAGGAGGAAGAAGAGGC	0.517000													23	27					0	0	1	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229899	140229899	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140229899C>T	ENST00000378122.3	+	1	2543	c.1819C>T	c.(1819-1821)Ctt>Ttt	p.L607F	PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Missense_Mutation_p.L607F|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAACGCGTGGCTTTCATACGA	0.672000													49	64					0	0	1	0	0
C12orf50	160419	broad.mit.edu	37	12	88379773	88379773	+	Missense_Mutation	SNP	C	C	T	rs78562422	byFrequency	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:88379773C>T	ENST00000298699.2	-	11	1160	c.980G>A	c.(979-981)cGa>cAa	p.R327Q	C12orf50_ENST00000550553.1_Missense_Mutation_p.R288Q	NM_152589.1	NP_689802.1	Q8NA57	CL050_HUMAN	chromosome 12 open reading frame 50	327								p.R327Q(1)		NS(1)|breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|skin(3)|urinary_tract(2)	34						CTCCGCATTTCGATTTTTATT	0.488000													9	67					0	0	1	0	0
RAB11FIP1	80223	broad.mit.edu	37	8	37732414	37732414	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:37732414G>A	ENST00000330843.4	-	3	1253	c.1241C>T	c.(1240-1242)cCc>cTc	p.P414L	RAB11FIP1_ENST00000524118.1_Missense_Mutation_p.P266L|RAB11FIP1_ENST00000287263.4_Missense_Mutation_p.P414L|RAB11FIP1_ENST00000522727.1_Missense_Mutation_p.P266L	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	414					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			TGAGTTTGCGGGGGCCATGTT	0.562000													38	53					0	0	1	0	0
TICAM1	148022	broad.mit.edu	37	19	4817136	4817136	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:4817136G>A	ENST00000248244.5	-	2	1483	c.1254C>T	c.(1252-1254)gcC>gcT	p.A418A		NM_182919.3	NP_891549.1	Q8IUC6	TCAM1_HUMAN	toll-like receptor adaptor molecule 1	418	TIR.				apoptosis|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein kinase binding|signal transducer activity			NS(2)|breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	26				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GCACGCCAAGGGCCTCCAGCT	0.612000													19	36					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42489288	42489288	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:42489288G>A	ENST00000545399.1	-	8	967	c.814C>T	c.(814-816)Cgt>Tgt	p.R272C	ATP1A3_ENST00000302102.5_Missense_Mutation_p.R259C|ATP1A3_ENST00000602133.1_Missense_Mutation_p.R229C|ATP1A3_ENST00000543770.1_Missense_Mutation_p.R270C	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	259					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						GTGGCGATACGGCCCATGACA	0.662000													15	14					0	0	1	0	0
PCDHA10	56139	broad.mit.edu	37	5	140236829	140236829	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140236829C>T	ENST00000307360.5	+	1	1196	c.1196C>T	c.(1195-1197)aCc>aTc	p.T399I	PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000506939.2_Missense_Mutation_p.T399I|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA4_ENST00000530339.1_Intron	NM_018901.2|NM_031859.1	NP_061724.1|NP_114065.1														NS(1)|breast(11)|cervix(1)|endometrium(11)|kidney(5)|large_intestine(13)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(2)	79			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGGTGTCCACCTACAAGAAT	0.592000													72	91					0	0	1	0	0
VCX2	51480	broad.mit.edu	37	X	8138246	8138246	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:8138246C>T	ENST00000317103.4	-	3	553	c.247G>A	c.(247-249)Gag>Aag	p.E83K		NM_016378.2	NP_057462.2	Q9H322	VCX2_HUMAN	variable charge, X-linked 2	83										endometrium(1)	1		Colorectal(8;0.0136)|Medulloblastoma(8;0.184)				TGAGGGAGCTCCTGGCTGGGC	0.697000													46	6					0	0	1	0	0
DKK2	27123	broad.mit.edu	37	4	107845207	107845207	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:107845207G>A	ENST00000285311.3	-	4	1389	c.684C>T	c.(682-684)ttC>ttT	p.F228F	DKK2_ENST00000513208.1_Silent_p.F128F|DKK2_ENST00000510463.1_Silent_p.F182F	NM_014421.2	NP_055236.1	Q9UBU2	DKK2_HUMAN	dickkopf WNT signaling pathway inhibitor 2	228	DKK-type Cys-2.				multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				autonomic_ganglia(1)|breast(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	32		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		CGCAACGCTGGAAAATTTCCA	0.493000													27	107					0	0	1	0	0
CPLX2	10814	broad.mit.edu	37	5	175306953	175306953	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:175306953G>A	ENST00000359546.4	+	5	953	c.310G>A	c.(310-312)Ggc>Agc	p.G104S	CPLX2_ENST00000515094.1_Missense_Mutation_p.G104S|CPLX2_ENST00000393745.3_Missense_Mutation_p.G104S	NM_001008220.1|NM_006650.3	NP_001008221.1|NP_006641.1	Q6PUV4	CPLX2_HUMAN	complexin 2	104					mast cell degranulation|positive regulation of synaptic plasticity|vesicle docking involved in exocytosis	cytosol				endometrium(3)|kidney(2)|lung(3)|ovary(2)	10	all_cancers(89;0.004)|Renal(175;0.000269)|Lung NSC(126;0.00441)|all_lung(126;0.00747)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			CATCCCTGCGGGCTGCGGGGA	0.627000													18	13					0	0	1	0	0
CCDC102B	79839	broad.mit.edu	37	18	66506047	66506047	+	Silent	SNP	G	G	A	rs147553785		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:66506047G>A	ENST00000360242.5	+	3	828	c.711G>A	c.(709-711)acG>acA	p.T237T	CCDC102B_ENST00000319445.6_Silent_p.T237T|CCDC102B_ENST00000358653.5_Silent_p.T237T|CCDC102B_ENST00000584156.1_Silent_p.T237T|CCDC102B_ENST00000577772.1_3'UTR	NM_024781.2	NP_079057.2	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	237										breast(2)|endometrium(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|stomach(1)	36		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				ACGGTGAAACGAAAACTGGGC	0.373000													19	34					0	0	1	0	0
DNAH1	25981	broad.mit.edu	37	3	52397078	52397078	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:52397078C>T	ENST00000420323.2	+	32	5423	c.5162C>T	c.(5161-5163)tCc>tTc	p.S1721F		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1721	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TCCCTCTATTCCTTTGGCTTT	0.532000													57	70					0	0	1	0	0
RNMTL1	55178	broad.mit.edu	37	17	685745	685745	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:685745C>T	ENST00000304478.4	+	1	233	c.127C>T	c.(127-129)Cct>Tct	p.P43S		NM_018146.2	NP_060616.1	Q9HC36	RMTL1_HUMAN	RNA methyltransferase like 1	43					RNA processing		protein binding|RNA binding|RNA methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (25;0.0219)		AGTGGTGTTTCCTTCCGGAGA	0.647000													19	10					0	0	1	0	0
ADH7	131	broad.mit.edu	37	4	100349304	100349304	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:100349304G>C	ENST00000437033.2	-	4	790	c.287C>G	c.(286-288)cCa>cGa	p.P96R	ADH7_ENST00000209665.4_Missense_Mutation_p.P108R|ADH7_ENST00000482593.1_Missense_Mutation_p.P39R|ADH7_ENST00000476959.1_Missense_Mutation_p.P116R			P40394	ADH7_HUMAN	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	108					ethanol oxidation|fatty acid omega-oxidation|response to bacterium|response to ethanol|xenobiotic metabolic process	cytosol|soluble fraction	alcohol dehydrogenase activity, zinc-dependent|aldehyde oxidase activity|ethanol binding|receptor antagonist activity|retinol binding|retinol dehydrogenase activity			breast(1)|central_nervous_system(2)|large_intestine(4)|lung(11)|skin(1)	19				OV - Ovarian serous cystadenocarcinoma(123;1.75e-08)	NADH(DB00157)	TCTACATTGTGGCAGAAAGAG	0.338000													22	63					0	0	1	0	0
MCHR2	84539	broad.mit.edu	37	6	100390904	100390904	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:100390904C>T	ENST00000281806.2	-	4	822	c.508G>A	c.(508-510)Gtc>Atc	p.V170I	MCHR2_ENST00000445970.1_Missense_Mutation_p.V170I|MCHR2_ENST00000369212.1_Missense_Mutation_p.V170I	NM_001040179.1	NP_001035269.1	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	170						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	39		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		TTCGAGTAGACCCAGACAGGC	0.453000													23	95					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216497555	216497555	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:216497555C>T	ENST00000366943.2	-	7	1669	c.1283G>A	c.(1282-1284)gGa>gAa	p.G428E	USH2A_ENST00000366942.3_Missense_Mutation_p.G428E|USH2A_ENST00000307340.3_Missense_Mutation_p.G428E			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	428	Laminin N-terminal.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTCCAAATCTCCATTGTTTTT	0.318000										HNSCC(13;0.011)			4	25					0	0	1	0	0
OR51B2	79345	broad.mit.edu	37	11	5344806	5344806	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:5344806G>A	ENST00000328813.2	-	1	776	c.722C>T	c.(721-723)tCc>tTc	p.S241F	HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_033180.4	NP_149420.4	Q9Y5P1	O51B2_HUMAN	olfactory receptor, family 51, subfamily B, member 2	241					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|biliary_tract(1)|central_nervous_system(1)|large_intestine(6)|lung(21)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTAATGTGGGAGATACAGGT	0.398000													26	28					0	0	1	0	0
FURIN	5045	broad.mit.edu	37	15	91421520	91421520	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:91421520C>T	ENST00000268171.3	+	8	1105	c.826C>T	c.(826-828)Cgt>Tgt	p.R276C		NM_002569.2	NP_002560.1	P09958	FURIN_HUMAN	furin (paired basic amino acid cleaving enzyme)	276					cell proliferation|negative regulation of low-density lipoprotein particle receptor catabolic process|negative regulation of transforming growth factor-beta1 production|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|Notch signaling pathway|peptide biosynthetic process|peptidyl-glutamic acid carboxylation|post-translational protein modification|secretion by cell|signal peptide processing|transforming growth factor beta receptor signaling pathway|viral assembly, maturation, egress, and release	cell surface|Golgi lumen|Golgi membrane|integral to membrane|membrane raft|plasma membrane|trans-Golgi network|trans-Golgi network transport vesicle	metal ion binding|nerve growth factor binding|peptide binding|protease binding|serine-type endopeptidase activity|serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(4)|endometrium(4)|large_intestine(3)|liver(2)|lung(13)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	36	Lung NSC(78;0.0771)|all_lung(78;0.137)		Lung(145;0.189)			GGCCTTCTTCCGTGGGGTTAG	0.587000													11	38					0	0	1	0	0
MYLK2	85366	broad.mit.edu	37	20	30409458	30409458	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:30409458C>T	ENST00000375994.2	+	3	963	c.690C>T	c.(688-690)ttC>ttT	p.F230F	MYLK2_ENST00000375985.4_Silent_p.F230F			Q9H1R3	MYLK2_HUMAN	myosin light chain kinase 2	230					cardiac muscle tissue morphogenesis|regulation of muscle filament sliding		ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			NS(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	33			Colorectal(19;0.00306)|COAD - Colon adenocarcinoma(19;0.0347)			GGATTGAGTTCCAGGCTGTTC	0.602000													30	149					0	0	1	0	0
USP32	84669	broad.mit.edu	37	17	58332545	58332545	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:58332545G>A	ENST00000300896.4	-	10	1259	c.1065C>T	c.(1063-1065)ctC>ctT	p.L355L	USP32_ENST00000393003.3_Silent_p.L355L|USP32_ENST00000592339.1_Silent_p.L25L	NM_032582.3	NP_115971.2	Q8NFA0	UBP32_HUMAN	ubiquitin specific peptidase 32	355					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(5)|endometrium(5)|kidney(4)|large_intestine(12)|liver(1)|lung(24)|pancreas(1)|prostate(3)|skin(3)|urinary_tract(1)	62	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			CCTGGAAAAGGAGGTTCAAAA	0.393000													17	26					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229773631	229773631	+	Missense_Mutation	SNP	G	G	C	rs146627260		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:229773631G>C	ENST00000258243.2	+	4	3407	c.3271G>C	c.(3271-3273)Gtt>Ctt	p.V1091L		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	1091						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						GCTGCAGCAGGTTGTGCTGCA	0.622000													20	98					0	0	1	0	0
ANKRD20A8P	729171	broad.mit.edu	37	2	95497757	95497757	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:95497757C>T	ENST00000432432.2	-	0	1086					NR_040113.1																						CTCACCTTCTCCTTGTCCATT	0.473000													72	124					0	0	1	0	0
MUC20	200958	broad.mit.edu	37	3	195452027	195452027	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:195452027C>T	ENST00000320736.6	+	2	679	c.553C>T	c.(553-555)Cca>Tca	p.P185S	MUC20_ENST00000445522.2_Missense_Mutation_p.P150S|MUC20_ENST00000447234.2_Missense_Mutation_p.P185S|MUC20_ENST00000436408.1_Missense_Mutation_p.P185S	NM_001098516.1|NM_152673.2	NP_001091986.1|NP_689886.2	Q8N307	MUC20_HUMAN	mucin 20, cell surface associated	356	12 X 20 AA approximate tandem repeats of S-S-E-S-S-A-S-S-D-S-P-H-P-V-I-T-P-S-R-A.|Ser-rich.		Missing.		protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane				NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)	23	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		CAGCCCCCATCCAGTCATCAC	0.612000													47	16					0	0	1	0	0
ZNF44	51710	broad.mit.edu	37	19	12383811	12383811	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:12383811G>A	ENST00000356109.5	-	5	1521	c.1403C>T	c.(1402-1404)cCc>cTc	p.P468L	ZNF44_ENST00000355684.5_Missense_Mutation_p.P420L	NM_001164276.1	NP_001157748.1	P15621	ZNF44_HUMAN	zinc finger protein 44	468					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		Renal(1328;0.157)		GBM - Glioblastoma multiforme(1328;0.0164)|Lung(535;0.179)		GCATTCATAGGGTTTCTCTCC	0.433000													13	30					0	0	1	0	0
EPHA7	2045	broad.mit.edu	37	6	93965644	93965644	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:93965644G>A	ENST00000369303.4	-	13	2468	c.2284C>T	c.(2284-2286)Cgc>Tgc	p.R762C		NM_004440.3	NP_004431.1	Q15375	EPHA7_HUMAN	EPH receptor A7	762	Protein kinase.					integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(7)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(16)|lung(43)|ovary(8)|pancreas(1)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(13)|urinary_tract(1)	112		all_cancers(76;7.47e-10)|Acute lymphoblastic leukemia(125;1.88e-09)|all_hematologic(75;1.75e-07)|all_epithelial(107;3.6e-05)|Lung NSC(302;0.0368)|all_lung(197;0.0509)|Colorectal(196;0.142)		BRCA - Breast invasive adenocarcinoma(108;0.0847)		AGAATATTGCGAGCTGCAAGG	0.423000													40	42					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	36241668	36241668	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:36241668G>A	ENST00000400445.3	+	56	9093	c.8559G>A	c.(8557-8559)ggG>ggA	p.G2853G	NBEA_ENST00000537702.1_Silent_p.G646G|NBEA_ENST00000379939.2_Silent_p.G2850G|NBEA_ENST00000540320.1_Silent_p.G2853G|NBEA_ENST00000379922.3_Silent_p.G431G|NBEA_ENST00000310336.4_Silent_p.G2853G	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	2853						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GCATTAATGGGAAACTTTTGG	0.403000													45	131					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113173532	113173532	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:113173532C>T	ENST00000401783.2	-	37	6795	c.6459G>A	c.(6457-6459)atG>atA	p.M2153I	SVEP1_ENST00000297826.5_Missense_Mutation_p.M79I|SVEP1_ENST00000374469.1_Missense_Mutation_p.M2130I	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2153	Sushi 13.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CATAGCCATTCATGATGCTTG	0.517000													30	13					0	0	1	0	0
SYT1	6857	broad.mit.edu	37	12	79747315	79747315	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:79747315C>T	ENST00000261205.4	+	9	1501	c.844C>T	c.(844-846)Cgc>Tgc	p.R282C	SYT1_ENST00000457153.2_Missense_Mutation_p.R279C|SYT1_ENST00000393240.3_Missense_Mutation_p.R282C|SYT1_ENST00000552744.1_Missense_Mutation_p.R282C	NM_005639.2	NP_005630.1	P21579	SYT1_HUMAN	synaptotagmin I	282	Phospholipid binding (Probable).				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|pancreas(2)|skin(6)	25						CTTCTCCCTTCGCTACGTACC	0.393000													24	86					0	0	1	0	0
MYO3A	53904	broad.mit.edu	37	10	26359298	26359298	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:26359298C>T	ENST00000265944.5	+	14	1493	c.1327C>T	c.(1327-1329)Ctt>Ttt	p.L443F	MYO3A_ENST00000543632.1_Missense_Mutation_p.L443F	NM_017433.4	NP_059129.3	Q8NEV4	MYO3A_HUMAN	myosin IIIA	443	Myosin head-like.				protein autophosphorylation|response to stimulus|sensory perception of sound|visual perception	cytoplasm|filamentous actin|filopodium|myosin complex	actin binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|plus-end directed microfilament motor activity|protein serine/threonine kinase activity			NS(2)|breast(9)|central_nervous_system(3)|endometrium(9)|kidney(10)|large_intestine(28)|liver(1)|lung(46)|ovary(11)|pancreas(1)|prostate(6)|skin(11)|stomach(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	146						AAATGCTCATCTTTTAGTTCA	0.323000													3	22					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5841679	5841679	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:5841679C>T	ENST00000317037.2	+	1	136	c.114C>T	c.(112-114)atC>atT	p.I38I	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	38					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TTATGTACATCATTGCTGTCG	0.557000													39	48					0	0	1	0	0
BAP1	8314	broad.mit.edu	37	3	52437159	52437159	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:52437159G>A	ENST00000460680.1	-	14	2356	c.1885C>T	c.(1885-1887)Ccc>Tcc	p.P629S	BAP1_ENST00000296288.5_Missense_Mutation_p.P611S	NM_004656.2	NP_004647.1	Q92560	BAP1_HUMAN	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)	629	Interaction with BRCA1.				monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			NS(1)|breast(4)|endometrium(3)|eye(42)|kidney(60)|large_intestine(3)|lung(9)|ovary(4)|pleura(39)|prostate(4)|skin(9)|urinary_tract(2)	180				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		CTCACCTTGGGTGAGTATTTC	0.577000			"""N, Mis, F, S, O"""		"""uveal melanoma, breast, NSCLC, RCC"""	"""mesothelioma, uveal melanoma"""							23	30					0	0	1	0	0
HAL	3034	broad.mit.edu	37	12	96379864	96379864	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:96379864G>A	ENST00000261208.3	-	13	1494	c.1126C>T	c.(1126-1128)Cac>Tac	p.H376Y	HAL_ENST00000541929.1_Missense_Mutation_p.H168Y|HAL_ENST00000538703.1_Missense_Mutation_p.H376Y	NM_002108.3	NP_002099.1	P42357	HUTH_HUMAN	histidine ammonia-lyase	376					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	34					L-Histidine(DB00117)	GATGGGTGGTGATCTGAGTCC	0.433000													22	19					0	0	1	0	0
WWTR1	25937	broad.mit.edu	37	3	149290772	149290772	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:149290772G>A	ENST00000465804.1	-	4	703	c.447C>T	c.(445-447)atC>atT	p.I149I	WWTR1_ENST00000467467.1_Silent_p.I149I|WWTR1_ENST00000360632.3_Silent_p.I149I	NM_001168278.1	NP_001161750.1	Q9GZV5	WWTR1_HUMAN	WW domain containing transcription regulator 1	149	WW.				hippo signaling cascade|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of protein kinase activity|negative regulation of protein phosphorylation|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|regulation of SMAD protein import into nucleus|stem cell division|transcription, DNA-dependent	cytoplasm	transcription coactivator activity			breast(5)|cervix(1)|endometrium(2)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|skin(1)	23			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GCCATGTGGTGATTTTTTCTA	0.408000			T	CAMTA1	epitheliod hemangioendothelioma								23	41					0	0	1	0	0
CPS1	1373	broad.mit.edu	37	2	211471650	211471650	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:211471650C>T	ENST00000233072.5	+	18	2373	c.2177C>T	c.(2176-2178)gCc>gTc	p.A726V	CPS1_ENST00000430249.2_Missense_Mutation_p.A732V|CPS1_ENST00000451903.2_Missense_Mutation_p.A275V	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	726	ATP-grasp 1.				carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity			breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		TCTGCTCTGGCCTCAAAAGCC	0.433000													17	31					0	0	1	0	0
POLR2B	5431	broad.mit.edu	37	4	57865805	57865805	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:57865805G>T	ENST00000381227.1	+	8	1171	c.758G>T	c.(757-759)gGt>gTt	p.G253V	POLR2B_ENST00000441246.2_Missense_Mutation_p.G246V|POLR2B_ENST00000431623.2_Missense_Mutation_p.G178V|POLR2B_ENST00000314595.5_Missense_Mutation_p.G253V			P30876	RPB2_HUMAN	polymerase (RNA) II (DNA directed) polypeptide B, 140kDa	253					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(1)|central_nervous_system(2)|endometrium(6)|kidney(10)|large_intestine(9)|lung(17)|ovary(2)|prostate(4)|skin(1)	52	Glioma(25;0.08)|all_neural(26;0.181)					AGTGCTATTGGTCAGCGCATT	0.353000													40	21					2.00842e-17	2.03334e-17	1	1	0
ZNF155	7711	broad.mit.edu	37	19	44500381	44500381	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:44500381C>T	ENST00000270014.2	+	5	500	c.372C>T	c.(370-372)ttC>ttT	p.F124F	ZNF155_ENST00000407951.2_Silent_p.F135F|ZNF155_ENST00000590615.1_Silent_p.F124F	NM_001260487.1|NM_198089.2	NP_001247416.1|NP_932355.2	Q12901	ZN155_HUMAN	zinc finger protein 155	124						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	15		Prostate(69;0.0352)				ACTCTCAGTTCTTTGAAAATG	0.458000													27	30					0	0	1	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101593742	101593742	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:101593742G>A	ENST00000310954.6	-	7	1464	c.1178C>T	c.(1177-1179)tCa>tTa	p.S393L		NM_180991.4	NP_851322.3	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family, member 4C1	393					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		TAAGGCTTCTGAAGAAGTTGA	0.318000													13	24					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30748969	30748969	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:30748969C>T	ENST00000262518.4	+	34	7993	c.7608C>T	c.(7606-7608)atC>atT	p.I2536I	SRCAP_ENST00000395059.2_Silent_p.I2474I|SRCAP_ENST00000344771.4_Silent_p.I2378I	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2536	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			CTGTGCCCATCTCTGCCTCAG	0.587000													48	72					0	0	1	0	0
WDR86	349136	broad.mit.edu	37	7	151082370	151082370	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:151082370C>T	ENST00000469830.2	-	4	771	c.730G>A	c.(730-732)Gag>Aag	p.E244K	WDR86_ENST00000477459.1_Intron|WDR86_ENST00000334493.6_Intron|WDR86_ENST00000463000.1_Intron			Q86TI4	WDR86_HUMAN	WD repeat domain 86	244										breast(1)|endometrium(2)|kidney(1)|lung(6)	10			OV - Ovarian serous cystadenocarcinoma(82;0.00419)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCAGACCTCTCCCTCTATAAG	0.647000													10	15					0	0	1	0	0
SBSN	374897	broad.mit.edu	37	19	36018807	36018807	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:36018807A>G	ENST00000452271.2	-	1	405	c.377T>C	c.(376-378)gTt>gCt	p.V126A	SBSN_ENST00000518157.1_Splice_Site	NM_001166034.1	NP_001159506.1	Q6UWP8	SBSN_HUMAN	suprabasin	126	Ala/Gly/His-rich.					extracellular region				large_intestine(5)|lung(6)|ovary(1)|prostate(2)	14	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			CTCCTTCCCAACCTGTCCAGC	0.562000													76	85					0	0	1	0	0
HIST1H3B	8358	broad.mit.edu	37	6	26032060	26032060	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:26032060G>A	ENST00000244661.2	-	1	228	c.229C>T	c.(229-231)Caa>Taa	p.Q77*		NM_003537.3	NP_003528.1	P68431	H31_HUMAN	histone cluster 1, H3b	77					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(3)|central_nervous_system(10)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(2)|skin(1)	25						TTGAAGTCTTGGGCGATTTCT	0.597000													77	76					0	0	1	0	0
DCAF4L1	285429	broad.mit.edu	37	4	41983993	41983993	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:41983993C>T	ENST00000333141.5	+	1	281	c.184C>T	c.(184-186)Cgg>Tgg	p.R62W		NM_001029955.3	NP_001025126.2	Q3SXM0	DC4L1_HUMAN	DDB1 and CUL4 associated factor 4-like 1	62										breast(1)|endometrium(5)|kidney(6)|large_intestine(11)|lung(12)|prostate(1)|skin(1)	37						GGTCCAAATTCGGAGCTTGGA	0.532000													16	55					0	0	1	0	0
ZNF573	126231	broad.mit.edu	37	19	38230877	38230877	+	Missense_Mutation	SNP	G	G	A	rs149253687	byFrequency	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:38230877G>A	ENST00000339503.4	-	8	841	c.340C>T	c.(340-342)Cgt>Tgt	p.R114C	ZNF573_ENST00000392138.1_Missense_Mutation_p.R85C|ZNF573_ENST00000585724.1_3'UTR|ZNF573_ENST00000536220.1_Missense_Mutation_p.R84C|ZNF573_ENST00000590414.2_Missense_Mutation_p.R172C|ZNF573_ENST00000357309.3_Missense_Mutation_p.R84C	NM_152360.3	NP_689573.3	Q86YE8	ZN573_HUMAN	zinc finger protein 573	152					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R114C(1)		NS(1)|cervix(3)|endometrium(2)|large_intestine(8)|liver(1)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)|Lung(45;0.0813)|LUSC - Lung squamous cell carcinoma(53;0.146)			TAGCCACTACGAAAGTTCTTC	0.373000													27	63					0	0	1	0	0
ATXN2L	11273	broad.mit.edu	37	16	28847497	28847497	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:28847497C>T	ENST00000336783.4	+	22	3306	c.3139C>T	c.(3139-3141)Cgt>Tgt	p.R1047C	RP11-24N18.1_ENST00000563565.1_RNA|ATXN2L_ENST00000340394.8_Intron|ATXN2L_ENST00000325215.6_Splice_Site_p.P1047_splice|ATXN2L_ENST00000382686.4_Intron|ATXN2L_ENST00000570200.1_Splice_Site_p.L1047_splice|ATXN2L_ENST00000395547.2_Splice_Site_p.L1047_splice|ATXN2L_ENST00000564304.1_Splice_Site_p.L1053_splice	NM_007245.3	NP_009176.2	Q8WWM7	ATX2L_HUMAN	ataxin 2-like	1047						membrane				breast(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36						TGACAGGATTCGTGAGTTCTC	0.612000													61	86					0	0	1	0	0
MAST2	23139	broad.mit.edu	37	1	46487735	46487735	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:46487735C>T	ENST00000361297.2	+	12	1687	c.1404C>T	c.(1402-1404)ctC>ctT	p.L468L	MAST2_ENST00000372009.2_Silent_p.L398L|MAST2_ENST00000372008.1_Silent_p.L353L	NM_015112.2	NP_055927.2	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase 2	468					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			breast(1)|lung(3)|ovary(5)|stomach(2)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					AGCTGGGCCTCACCCGGGATC	0.552000													138	55					0	0	1	0	0
ZMAT1	84460	broad.mit.edu	37	X	101159207	101159207	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:101159207G>A	ENST00000372782.3	-	3	265	c.218C>T	c.(217-219)tCa>tTa	p.S73L	ZMAT1_ENST00000540921.1_Missense_Mutation_p.S73L|ZMAT1_ENST00000458570.1_5'UTR	NM_001011657.3	NP_001011657.2	A7MD47	A7MD47_HUMAN	zinc finger, matrin-type 1	0						nucleus	zinc ion binding			endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	22						CTCATAATGTGAAATTCTTTG	0.343000													16	2					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	16	70871596	70871596	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:70871596C>T	ENST00000393567.2	-	77	13389	c.13239G>A	c.(13237-13239)atG>atA	p.M4413I		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	4413										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				CTGTTACCTTCATTTTGGTAC	0.488000													21	37					0	0	1	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43871859	43871859	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:43871859G>A	ENST00000282406.4	+	2	157	c.47G>A	c.(46-48)cGa>cAa	p.R16Q		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	16						cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TGGAAGGAACGATGTGTAGCT	0.358000													7	7					0	0	1	0	0
INHBE	83729	broad.mit.edu	37	12	57850021	57850021	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:57850021G>A	ENST00000266646.2	+	2	659	c.443G>A	c.(442-444)aGg>aAg	p.R148K	INHBE_ENST00000551553.1_3'UTR	NM_031479.3	NP_113667.1	P58166	INHBE_HUMAN	inhibin, beta E	148					growth	extracellular region	growth factor activity|hormone activity			breast(2)|central_nervous_system(1)|large_intestine(2)|lung(7)|prostate(1)|skin(2)	15						TGGGGACCAAGGAGGAGGCGC	0.622000											OREG0021944	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	42	131					0	0	1	0	0
CLPB	81570	broad.mit.edu	37	11	72084027	72084027	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:72084027G>A	ENST00000294053.3	-	5	851	c.678C>T	c.(676-678)atC>atT	p.I226I	CLPB_ENST00000543042.1_Intron|CLPB_ENST00000437826.2_Silent_p.I181I|CLPB_ENST00000538039.1_Intron|CLPB_ENST00000340729.5_Intron|CLPB_ENST00000445069.2_Silent_p.I122I	NM_001258394.1|NM_030813.4	NP_001245323.1|NP_110440.1	Q9H078	CLPB_HUMAN	ClpB caseinolytic peptidase B homolog (E. coli)	226					cellular response to heat		ATP binding|nucleoside-triphosphatase activity|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(7)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	19						ACTGGTTTGTGATGTGCCGGC	0.597000													39	44					0	0	1	0	0
ZNF12	7559	broad.mit.edu	37	7	6731140	6731140	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:6731140G>A	ENST00000405858.1	-	5	1974	c.1433C>T	c.(1432-1434)tCa>tTa	p.S478L	AC073343.13_ENST00000366167.2_RNA|ZNF12_ENST00000404360.1_Missense_Mutation_p.S404L|ZNF12_ENST00000342651.5_Missense_Mutation_p.S440L	NM_006956.2|NM_016265.3	NP_008887.2|NP_057349.2	P17014	ZNF12_HUMAN	zinc finger protein 12	478					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(3)	16		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		CATGAGGGCTGAATTCAGGTA	0.398000													28	38					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2721172	2721172	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:2721172A>T	ENST00000399655.1	+	29	4086	c.3821A>T	c.(3820-3822)aAa>aTa	p.K1274I	CACNA1C_ENST00000399595.1_Missense_Mutation_p.K1274I|CACNA1C_ENST00000399634.1_Missense_Mutation_p.K1274I|CACNA1C_ENST00000327702.7_Missense_Mutation_p.K1274I|CACNA1C_ENST00000399606.1_Missense_Mutation_p.K1294I|CACNA1C_ENST00000399637.1_Missense_Mutation_p.K1274I|CACNA1C_ENST00000399591.1_Missense_Mutation_p.K1274I|CACNA1C_ENST00000399621.1_Missense_Mutation_p.K1274I|CACNA1C_ENST00000406454.3_Missense_Mutation_p.K1274I|CACNA1C_ENST00000335762.5_Missense_Mutation_p.K1299I|CACNA1C_ENST00000399601.1_Missense_Mutation_p.K1274I|CACNA1C_ENST00000347598.4_Missense_Mutation_p.K1294I|CACNA1C_ENST00000344100.3_Missense_Mutation_p.K1274I|CACNA1C_ENST00000399603.1_Missense_Mutation_p.K1274I|CACNA1C_ENST00000399649.1_Missense_Mutation_p.K1274I|CACNA1C_ENST00000399597.1_Missense_Mutation_p.K1274I|CACNA1C_ENST00000480911.1_Missense_Mutation_p.K1274I|CACNA1C_ENST00000399638.1_Missense_Mutation_p.K1274I|CACNA1C_ENST00000399629.1_Missense_Mutation_p.K1274I|CACNA1C_ENST00000402845.3_Missense_Mutation_p.K1274I|CACNA1C_ENST00000399617.1_Missense_Mutation_p.K1274I|CACNA1C_ENST00000399641.1_Missense_Mutation_p.K1274I|CACNA1C_ENST00000399644.1_Missense_Mutation_p.K1274I	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1294					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	ATTGCCTTCAAACCCAAGGTA	0.532000													9	29					0	0	1	0	0
PADI4	23569	broad.mit.edu	37	1	17657611	17657611	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:17657611G>A	ENST00000375448.4	+	2	266	c.240G>A	c.(238-240)atG>atA	p.M80I	AC004824.2_ENST00000602074.1_Intron|PADI4_ENST00000375453.1_Missense_Mutation_p.M80I	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	80					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CCCTGACGATGAAAGTGGCCA	0.602000													9	63					0	0	1	0	0
GALNT10	55568	broad.mit.edu	37	5	153766009	153766009	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:153766009C>T	ENST00000425427.2	+	7	1212	c.1075C>T	c.(1075-1077)Cgc>Tgc	p.R359C	GALNT10_ENST00000297107.6_Intron|GALNT10_ENST00000377661.2_Intron|GALNT10_ENST00000519544.1_Intron|SAP30L-AS1_ENST00000519727.1_RNA			Q86SR1	GLT10_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10)	0	Catalytic subdomain B.					Golgi membrane|integral to membrane	metal ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(12)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	32	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)|all_hematologic(541;0.21)	Kidney(363;8.21e-05)|KIRC - Kidney renal clear cell carcinoma(527;0.000577)			GCTCTCCAGACGCCCCGTTCT	0.587000													3	42					0	0	1	0	0
MXRA5	25878	broad.mit.edu	37	X	3235257	3235257	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:3235257C>T	ENST00000217939.6	-	6	6619	c.6465G>A	c.(6463-6465)agG>agA	p.R2155R		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	2155	Ig-like C2-type 6.					extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGACGTCCGTCCTCCGCGGGG	0.701000													18	6					0	0	1	0	0
OR2L3	391192	broad.mit.edu	37	1	248224278	248224278	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:248224278C>T	ENST00000359959.3	+	1	295	c.295C>T	c.(295-297)Cag>Tag	p.Q99*	OR2L13_ENST00000366478.2_Intron	NM_001004687.1	NP_001004687.1	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L, member 3	99					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(2)|large_intestine(7)|lung(28)|prostate(1)|skin(1)|urinary_tract(1)	41	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			GTGTGGGATTCAGAGTTTCTT	0.433000													115	89					0	0	1	0	0
GALNT8	26290	broad.mit.edu	37	12	4872538	4872538	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:4872538C>T	ENST00000252318.2	+	8	1816	c.1479C>T	c.(1477-1479)acC>acT	p.T493T		NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	493						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						CACTCCACACCATCGTGGGCT	0.413000													20	40					0	0	1	0	0
SNX31	169166	broad.mit.edu	37	8	101608869	101608869	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:101608869G>A	ENST00000311812.2	-	10	1126	c.976C>T	c.(976-978)Ctt>Ttt	p.L326F	SNX31_ENST00000519521.1_5'UTR|SNX31_ENST00000428383.2_Missense_Mutation_p.L227F	NM_152628.3	NP_689841.3	Q8N9S9	SNX31_HUMAN	sorting nexin 31	326					cell communication|protein transport		phosphatidylinositol binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|prostate(1)|skin(3)|urinary_tract(1)	26	all_cancers(14;4.01e-05)|all_epithelial(15;1.26e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;1.21e-11)|all cancers(13;2.62e-09)|OV - Ovarian serous cystadenocarcinoma(57;3.22e-06)|STAD - Stomach adenocarcinoma(118;0.206)			ATACTCACAAGGAAAGTGACC	0.488000													18	36					0	0	1	0	0
DHX33	56919	broad.mit.edu	37	17	5359380	5359380	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:5359380G>A	ENST00000433302.3	-	2	468	c.412C>T	c.(412-414)Cct>Tct	p.P138S	DHX33_ENST00000225296.3_Silent_p.V324V			Q9H6R0	DHX33_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 33	0	Helicase ATP-binding.					nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						ACAGAGGAAGGACCAGCATCG	0.602000													18	8					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57769535	57769535	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:57769535C>T	ENST00000371030.2	+	1	3461	c.3461C>T	c.(3460-3462)tCc>tTc	p.S1154F		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1154						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GCCTTGTCTTCCCACTCAGGG	0.682000													22	138					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113395796	113395796	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:113395796C>T	ENST00000297405.5	-	37	6275	c.6031_splice	c.e37+1	p.G2011_splice	CSMD3_ENST00000343508.3_Splice_Site_p.G1971_splice|CSMD3_ENST00000455883.2_Splice_Site_p.G1907_splice|CSMD3_ENST00000352409.3_Splice_Site_p.G1941_splice	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2011	CUB 11.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TCTTATTTACCTGAATAGCTT	0.333000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			13	17					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	30071464	30071464	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:30071464G>C	ENST00000431530.3	+	11	3757	c.3699G>C	c.(3697-3699)gaG>gaC	p.E1233D	MTUS2_ENST00000380808.2_Missense_Mutation_p.E202D|MTUS2_ENST00000542829.1_Missense_Mutation_p.E112D|MTUS2_ENST00000400542.3_3'UTR	NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	1223						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						ACACAGAGGAGCAGCTGGAGG	0.622000													13	9					0	0	1	0	0
NRK	203447	broad.mit.edu	37	X	105197109	105197109	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:105197109G>A	ENST00000428173.2	+	28	4903	c.4600G>A	c.(4600-4602)Gag>Aag	p.E1534K	NRK_ENST00000243300.9_Missense_Mutation_p.E1533K|NRK_ENST00000540278.1_Missense_Mutation_p.E114K			Q7Z2Y5	NRK_HUMAN	Nik related kinase	1533	CNH.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						TCTGGAAAGTGAGCTGAAGCG	0.468000										HNSCC(51;0.14)			7	0					0	0	1	0	0
HAO2	51179	broad.mit.edu	37	1	119929329	119929329	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:119929329C>T	ENST00000361035.4	+	6	968	c.685C>T	c.(685-687)Cga>Tga	p.R229*	HAO2_ENST00000325945.3_Nonsense_Mutation_p.R216*	NM_001005783.1	NP_001005783.1	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2 (long chain)	216	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	30	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		GAGCATAACTCGATTGCCCAT	0.428000													21	65					0	0	1	0	0
ADAM2	2515	broad.mit.edu	37	8	39613338	39613338	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:39613338C>T	ENST00000265708.4	-	16	1809	c.1706G>A	c.(1705-1707)gGa>gAa	p.G569E	ADAM2_ENST00000521880.1_Intron|ADAM2_ENST00000379853.2_Missense_Mutation_p.G413E|ADAM2_ENST00000347580.4_Missense_Mutation_p.G550E	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	569	Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		GCAGAGATGTCCACTTATGTT	0.348000													11	32					0	0	1	0	0
KCNC2	3747	broad.mit.edu	37	12	75436945	75436945	+	Silent	SNP	T	T	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:75436945T>G	ENST00000549446.1	-	5	2537	c.1857A>C	c.(1855-1857)tcA>tcC	p.S619S	KCNC2_ENST00000540018.1_Silent_p.S564S|KCNC2_ENST00000350228.2_Intron|RP11-81K13.1_ENST00000550049.1_RNA|KCNC2_ENST00000548513.1_Intron|RP11-81K13.1_ENST00000547040.1_RNA|KCNC2_ENST00000550433.1_Intron|KCNC2_ENST00000298972.1_Intron|KCNC2_ENST00000341669.3_Intron	NM_001260497.1|NM_139137.3	NP_001247426.1|NP_631875.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	619					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						AGTTGTAGGGTGATGTTACTG	0.443000													11	39					0	0	1	0	0
AR	367	broad.mit.edu	37	X	66905910	66905910	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:66905910G>A	ENST00000374690.3	+	3	2351	c.1827G>A	c.(1825-1827)agG>agA	p.R609R	AR_ENST00000396043.2_Silent_p.R77R|AR_ENST00000504326.1_Silent_p.R609R|AR_ENST00000396044.3_Silent_p.R609R|AR_ENST00000513847.1_3'UTR	NM_000044.3	NP_000035.2	P10275	ANDR_HUMAN	androgen receptor	608	Interaction with HIPK3 (By similarity).				cell death|cell growth|cell proliferation|cell-cell signaling|negative regulation of apoptosis|negative regulation of integrin biosynthetic process|positive regulation of cell proliferation|positive regulation of integrin biosynthetic process|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|regulation of establishment of protein localization in plasma membrane|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transport	cytoplasm|nuclear chromatin|nucleoplasm	androgen binding|androgen receptor activity|beta-catenin binding|enzyme binding|ligand-regulated transcription factor activity|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|zinc ion binding			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|prostate(11)|stomach(2)|upper_aerodigestive_tract(3)	67	all_cancers(1;0.173)|Prostate(1;2.27e-16)|all_epithelial(1;0.102)	all_lung(315;1.3e-11)			Bicalutamide(DB01128)|Cyproterone(DB04839)|Dromostanolone(DB00858)|Finasteride(DB01216)|Fluoxymesterone(DB01185)|Flutamide(DB00499)|Nandrolone(DB00984)|Nilutamide(DB00665)|Oxandrolone(DB00621)|Testosterone(DB00624)	AATTCCGAAGGAAAAATTGTC	0.428000									Androgen Insensitivity Syndrome				29	5					0	0	1	0	0
PTGDR	5729	broad.mit.edu	37	14	52734901	52734901	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:52734901C>T	ENST00000306051.2	+	1	471	c.369C>T	c.(367-369)ctC>ctT	p.L123L	PTGDR_ENST00000553372.1_Silent_p.L123L	NM_000953.2	NP_000944.1	Q13258	PD2R_HUMAN	prostaglandin D2 receptor (DP)	123						integral to membrane|plasma membrane	prostaglandin D receptor activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(15)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Breast(41;0.0639)|all_epithelial(31;0.0887)				Nedocromil(DB00716)	CACTGCAACTCCTGGCCATGG	0.627000													36	130					0	0	1	0	0
KDM5B	10765	broad.mit.edu	37	1	202715047	202715047	+	Silent	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:202715047A>G	ENST00000367265.3	-	16	3426	c.2262T>C	c.(2260-2262)tcT>tcC	p.S754S	KDM5B_ENST00000367264.2_Silent_p.S790S	NM_006618.3	NP_006609.3	Q9UGL1	KDM5B_HUMAN	lysine (K)-specific demethylase 5B	754					negative regulation of transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-trimethyl-K4 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(2)|ovary(2)|skin(1)|urinary_tract(1)	6						ATTCGTTGTAAGATTCTGCTC	0.413000													115	43					0	0	1	0	0
KIAA1524	57650	broad.mit.edu	37	3	108295124	108295124	+	Silent	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:108295124A>G	ENST00000295746.8	-	8	964	c.888T>C	c.(886-888)tcT>tcC	p.S296S	KIAA1524_ENST00000487834.1_5'UTR|KIAA1524_ENST00000491772.1_Silent_p.S137S	NM_020890.2	NP_065941.2	Q8TCG1	CIP2A_HUMAN	KIAA1524	296						cytoplasm|integral to membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(21)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						ATACCTTTGAAGAGGAATCAG	0.294000													25	40					0	0	1	0	0
ZNRF3	84133	broad.mit.edu	37	22	29446917	29446917	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:29446917C>T	ENST00000544604.2	+	8	2923	c.2748C>T	c.(2746-2748)acC>acT	p.T916T	ZNRF3_ENST00000406323.3_Silent_p.T816T|ZNRF3_ENST00000402174.1_Silent_p.T816T|ZNRF3_ENST00000332811.4_Silent_p.T816T	NM_001206998.1	NP_001193927.1	Q9ULT6	ZNRF3_HUMAN	zinc and ring finger 3	916						integral to membrane	zinc ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(4)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	28						AGTCCAGCACCACTGCCACTG	0.597000													14	6					0	0	1	0	0
ZNF532	55205	broad.mit.edu	37	18	56586314	56586314	+	Silent	SNP	C	C	T	rs146293537		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:56586314C>T	ENST00000336078.4	+	4	1571	c.795C>T	c.(793-795)tcC>tcT	p.S265S	ZNF532_ENST00000591230.1_Silent_p.S265S|ZNF532_ENST00000589288.1_Silent_p.S265S|ZNF532_ENST00000591808.1_Silent_p.S265S|ZNF532_ENST00000591083.1_Silent_p.S265S	NM_018181.4	NP_060651.2	Q9HCE3	ZN532_HUMAN	zinc finger protein 532	265					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(14)|kidney(1)|large_intestine(9)|lung(14)|prostate(1)|skin(4)|urinary_tract(1)	52						AGTCGTCCTCCAAGCTCTCGT	0.562000													41	44					0	0	1	0	0
PCDHA5	56143	broad.mit.edu	37	5	140203522	140203522	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140203522G>A	ENST00000529859.1	+	1	2162	c.2162G>A	c.(2161-2163)cGg>cAg	p.R721Q	PCDHA5_ENST00000529619.1_Missense_Mutation_p.R721Q|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.R721Q|PCDHA4_ENST00000530339.1_Intron	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCGCGCTGCGGTGCTCGGCG	0.667000													25	68					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196577372	196577372	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:196577372C>T	ENST00000367433.5	-	1	169	c.68G>A	c.(67-69)gGg>gAg	p.G23E	KCNT2_ENST00000451324.2_5'UTR|KCNT2_ENST00000367431.4_Missense_Mutation_p.G23E|KCNT2_ENST00000294725.8_Missense_Mutation_p.G23E			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	23						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity	p.G23V(1)		NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						TCCTTGGTCCCCTAGCAGCAA	0.507000													20	97					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140750188	140750188	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140750188C>T	ENST00000576222.1	+	1	358	c.227C>T	c.(226-228)aCc>aTc	p.T76I	PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAATTCTTTACCGTGAGCCCC	0.512000													79	118					0	0	1	0	0
ADAM21P1	145241	broad.mit.edu	37	14	70713174	70713174	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:70713174C>T	ENST00000530196.1	-	0	1344					NR_003951.1																						ATAAAGATTTCCCCCAATCTT	0.458000													37	18					0	0	1	0	0
SUCO	51430	broad.mit.edu	37	1	172501615	172501615	+	Translation_Start_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:172501615G>A	ENST00000367723.3	+	1	127	c.3G>A	c.(1-3)atG>atA	p.M1I		NM_016227.2	NP_057311.2			SUN domain containing ossification factor																		CCAATCAGATGAGAGGATTCT	0.498000													23	7					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10465469	10465469	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:10465469C>T	ENST00000382483.3	-	4	6362	c.6139G>A	c.(6139-6141)Gat>Aat	p.D2047N		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	2047					intracellular signal transduction			p.D2047N(1)		breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GGCTGGGCATCCCCTTCTGTC	0.637000													143	231					0	0	1	0	0
PRUNE2	158471	broad.mit.edu	37	9	79326062	79326062	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:79326062G>A	ENST00000428286.1	-	8	1251	c.51C>T	c.(49-51)gcC>gcT	p.A17A	PRUNE2_ENST00000376718.3_Silent_p.A376A			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	376					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GGGAGAGGGGGGCACTGCCTG	0.517000													9	4					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9065502	9065502	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:9065502G>T	ENST00000397910.4	-	3	22147	c.21944C>A	c.(21943-21945)tCc>tAc	p.S7315Y		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7317	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CAGGATGGGGGAAGTAGGGAA	0.448000													11	25					4.68919e-08	4.7181e-08	1	1	0
MTHFD2L	441024	broad.mit.edu	37	4	75091054	75091054	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:75091054C>T	ENST00000395759.2	+	6	775	c.748C>T	c.(748-750)Ccc>Tcc	p.P250S	MTHFD2L_ENST00000325278.6_Missense_Mutation_p.P192S|MTHFD2L_ENST00000433372.1_Missense_Mutation_p.P115S|MTHFD2L_ENST00000331145.6_Missense_Mutation_p.P192S	NM_001144978.1	NP_001138450.1	Q9H903	MTD2L_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like	192					folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process		binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity			central_nervous_system(1)|endometrium(1)|lung(4)|ovary(2)	8			all cancers(17;0.0101)|Lung(101;0.196)			CAGATACACCCCCAAAGAGCA	0.368000													15	72					0	0	1	0	0
ZNF425	155054	broad.mit.edu	37	7	148801719	148801719	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:148801719G>A	ENST00000378061.2	-	4	1376	c.1244C>T	c.(1243-1245)tCg>tTg	p.S415L		NM_001001661.2	NP_001001661.1	Q6IV72	ZN425_HUMAN	zinc finger protein 425	415					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(6)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	50	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CTCGGGACACGAAAAGGGCTT	0.532000													26	112					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168620520	168620520	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:168620520C>T	ENST00000519560.1	-	4	795	c.376G>A	c.(376-378)Gaa>Aaa	p.E126K	SLIT3_ENST00000521130.1_5'UTR|SLIT3_ENST00000332966.8_Missense_Mutation_p.E126K|SLIT3_ENST00000404867.3_Missense_Mutation_p.E126K	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	126					apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAAAGCAATTCTGGAAGGACT	0.478000													25	37					0	0	1	0	0
PDZRN4	29951	broad.mit.edu	37	12	41961618	41961618	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:41961618G>T	ENST00000298919.7	+	9	1109	c.721G>T	c.(721-723)Gaa>Taa	p.E241*	PDZRN4_ENST00000402685.2_Nonsense_Mutation_p.E501*|PDZRN4_ENST00000539469.2_Nonsense_Mutation_p.E243*			Q6ZMN7	PZRN4_HUMAN	PDZ domain containing ring finger 4	501	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(29)|ovary(3)|pancreas(1)|prostate(2)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	77	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TGAAAGGAATGAATTCTTAGA	0.393000													14	37					3.27435e-08	3.29599e-08	1	1	0
PROL1	58503	broad.mit.edu	37	4	71265043	71265043	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:71265043C>T	ENST00000399575.2	+	2	215	c.41C>T	c.(40-42)tCa>tTa	p.S14L	PROL1_ENST00000514338.1_3'UTR	NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	14					regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				GCTCTTATTTCATGTTTCACA	0.318000													11	9					0	0	1	0	0
OR10K1	391109	broad.mit.edu	37	1	158435404	158435404	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:158435404C>T	ENST00000289451.2	+	1	133	c.53C>T	c.(52-54)tCa>tTa	p.S18L		NM_001004473.1	NP_001004473.1	Q8NGX5	O10K1_HUMAN	olfactory receptor, family 10, subfamily K, member 1	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	27	all_hematologic(112;0.0378)					CTCGGCTTCTCATCCCTGGCC	0.512000													11	71					0	0	1	0	0
ARPP21	10777	broad.mit.edu	37	3	35833953	35833953	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:35833953G>A	ENST00000187397.4	+	19	2568	c.2112G>A	c.(2110-2112)gtG>gtA	p.V704V	ARPP21_ENST00000417925.1_Silent_p.V705V|ARPP21_ENST00000476052.1_3'UTR|ARPP21_ENST00000444190.1_Silent_p.V685V|ARPP21_ENST00000337271.5_Silent_p.V685V|ARPP21_ENST00000458225.1_Silent_p.V705V	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	704	Gln-rich.					cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						GTCAGAACGTGATAAATAACC	0.468000													63	68					0	0	1	0	0
ACCS	84680	broad.mit.edu	37	11	44105063	44105063	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:44105063C>T	ENST00000263776.8	+	14	1778	c.1344C>T	c.(1342-1344)ttC>ttT	p.F448F		NM_001127219.1|NM_032592.3	NP_001120691.1|NP_115981.1	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)	448							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(4)|endometrium(3)|large_intestine(11)|lung(15)|ovary(1)|skin(1)	35						GCAAGGCCTTCGAGTGTAAAG	0.572000													22	37					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53674976	53674976	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:53674976G>A	ENST00000262135.4	-	19	3020	c.2927C>T	c.(2926-2928)tCt>tTt	p.S976F	RPGRIP1L_ENST00000563746.1_Missense_Mutation_p.S976F|RPGRIP1L_ENST00000379925.3_Missense_Mutation_p.S976F|RPGRIP1L_ENST00000564374.1_Missense_Mutation_p.S976F	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	976					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				ATCCACGAAAGATACCTTCTT	0.343000													7	18					0	0	1	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33631484	33631484	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:33631484T>C	ENST00000321505.4	+	14	4540	c.4360T>C	c.(4360-4362)Tgt>Cgt	p.C1454R	KIAA1549L_ENST00000389726.3_Missense_Mutation_p.C1460R					KIAA1549-like																		TTCAGAACTCTGTGCTCCATT	0.483000													32	39					0	0	1	0	0
GPR98	84059	broad.mit.edu	37	5	90052934	90052934	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:90052934G>A	ENST00000405460.2	+	57	11992	c.11896G>A	c.(11896-11898)Gac>Aac	p.D3966N		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	3966	Calx-beta 26.				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TGGCCTGGAAGACTTTAAACC	0.428000													11	19					0	0	1	0	0
OR52E8	390079	broad.mit.edu	37	11	5878393	5878393	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:5878393G>A	ENST00000537935.1	-	1	571	c.540C>T	c.(538-540)atC>atT	p.I180I	TRIM5_ENST00000380027.1_Intron	NM_001005168.1	NP_001005168.1	Q6IFG1	O52E8_HUMAN	olfactory receptor, family 52, subfamily E, member 8	180					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.114)		Epithelial(150;2.37e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AAGTATGAGGGATGATACGAT	0.507000													46	66					0	0	1	0	0
OR52M1	119772	broad.mit.edu	37	11	4567189	4567189	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:4567189C>T	ENST00000360213.1	+	1	769	c.769C>T	c.(769-771)Ccc>Tcc	p.P257S		NM_001004137.1	NP_001004137.1	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M, member 1	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|lung(9)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTTTTATGTTCCCATTGCTGT	0.517000													34	54					0	0	1	0	0
NAT10	55226	broad.mit.edu	37	11	34133673	34133673	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:34133673C>T	ENST00000257829.3	+	4	481	c.275C>T	c.(274-276)cCc>cTc	p.P92L	NAT10_ENST00000531159.2_Missense_Mutation_p.P20L|NAT10_ENST00000527971.1_Missense_Mutation_p.P92L	NM_024662.2	NP_078938.2	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 (GCN5-related)	92						nucleolus	ATP binding|N-acetyltransferase activity|protein binding			endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				CAGGACGACCCCTTTGAACTC	0.483000													17	31					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93108737	93108737	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:93108737C>T	ENST00000359558.2	-	5	487	c.188G>A	c.(187-189)cGa>cAa	p.R63Q	CALCR_ENST00000360249.4_Missense_Mutation_p.R45Q|CALCR_ENST00000421592.1_Missense_Mutation_p.R45Q|CALCR_ENST00000394441.1_Missense_Mutation_p.R45Q|CALCR_ENST00000426151.1_Missense_Mutation_p.R45Q	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	45					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	CATCTTCTTTCGTCCTACGAC	0.403000													54	93					0	0	1	0	0
CR1L	1379	broad.mit.edu	37	1	207850845	207850845	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:207850845C>T	ENST00000508064.2	+	2	269	c.209C>T	c.(208-210)tCc>tTc	p.S70F	CR1L_ENST00000530905.1_3'UTR	NM_175710.1	NP_783641.1	Q2VPA4	CR1L_HUMAN	complement component (3b/4b) receptor 1-like	70	Sushi 1.					cytoplasm|extracellular region|membrane				endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	22						CCTGGTTATTCCGGAAGACCG	0.473000													20	157					0	0	1	0	0
SEPT14	346288	broad.mit.edu	37	7	55863771	55863771	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:55863771G>A	ENST00000388975.3	-	10	1250	c.1134C>T	c.(1132-1134)ttC>ttT	p.F378F		NM_207366.2	NP_997249.2	Q6ZU15	SEP14_HUMAN	septin 14	378					cell cycle|cell division	septin complex	GTP binding|protein binding	p.F378F(1)|p.F167F(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(15)|skin(2)	23	Breast(14;0.214)		Lung(13;0.00024)|LUSC - Lung squamous cell carcinoma(13;0.00099)			TAAGATGCTCGAACTTGTCCT	0.378000													7	19					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71500280	71500280	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:71500280C>T	ENST00000396073.3	+	6	747	c.466C>T	c.(466-468)Cct>Tct	p.P156S		NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	156					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			AGCTCAACCCCCTCAGGTGAG	0.493000													25	19					0	0	1	0	0
ACTG1P17	283693	broad.mit.edu	37	15	83395674	83395674	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:83395674G>A	ENST00000560958.1	-	0	612					NR_036446.1																						GACTGGGAGAGGGTGGCTGTA	0.617000													3	1					0	0	1	0	0
TCIRG1	10312	broad.mit.edu	37	11	67809240	67809240	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:67809240C>T	ENST00000265686.3	+	3	246	c.138C>T	c.(136-138)gcC>gcT	p.A46A		NM_006019.3	NP_006010.2	Q13488	VPP3_HUMAN	T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3	46					ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			breast(1)|endometrium(4)|large_intestine(3)|lung(4)|ovary(3)|prostate(1)	16						CGGTGAGCGCCTTCCAGAGAC	0.622000													8	11					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110460509	110460509	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:110460509C>T	ENST00000378402.5	+	39	6018	c.5914C>T	c.(5914-5916)Cat>Tat	p.H1972Y		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1972	IPT/TIG 12.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CGTGGGAGATCATGCTGGGGG	0.408000										HNSCC(38;0.096)			11	11					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25231979	25231979	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:25231979G>A	ENST00000551631.2	+	0	887				SNHG14_ENST00000551361.1_RNA	NR_001293.1																						ATCTCTGGAAGAGATGACACg	0.483000													9	9					0	0	1	0	0
AOC3	8639	broad.mit.edu	37	17	41004743	41004743	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:41004743C>T	ENST00000308423.2	+	1	1543	c.1383C>T	c.(1381-1383)gtC>gtT	p.V461V		NM_003734.2	NP_003725.1	Q16853	AOC3_HUMAN	amine oxidase, copper containing 3	461					amine metabolic process|cell adhesion|inflammatory response	cell surface|integral to membrane|plasma membrane	aliphatic-amine oxidase activity|aminoacetone:oxygen oxidoreductase(deaminating) activity|copper ion binding|phenethylamine:oxygen oxidoreductase (deaminating) activity|primary amine oxidase activity|protein homodimerization activity|quinone binding|tryptamine:oxygen oxidoreductase (deaminating) activity			breast(1)|central_nervous_system(4)|endometrium(4)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|skin(8)	41		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.156)	Hydralazine(DB01275)|Phenelzine(DB00780)	CGGTGCTGGTCGTCAGATCTA	0.537000													26	54					0	0	1	0	0
GPHN	10243	broad.mit.edu	37	14	67567593	67567593	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:67567593C>T	ENST00000478722.1	+	13	2379	c.1258C>T	c.(1258-1260)Cgt>Tgt	p.R420C	GPHN_ENST00000543237.1_Missense_Mutation_p.R433C|GPHN_ENST00000305960.9_Missense_Mutation_p.R356C|GPHN_ENST00000544752.2_3'UTR|GPHN_ENST00000315266.5_Missense_Mutation_p.R387C	NM_020806.4	NP_065857.1	Q9NQX3	GEPH_HUMAN	gephyrin	387	MPT adenylyltransferase.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cell junction|cytoplasm|cytoskeleton|postsynaptic membrane	ATP binding|metal ion binding|nucleotidyltransferase activity			large_intestine(8)|liver(1)|ovary(2)|stomach(1)	12		all_cancers(7;0.0476)|all_hematologic(31;0.0116)		Epithelial(1;1.73e-08)|all cancers(60;3.15e-07)|OV - Ovarian serous cystadenocarcinoma(108;0.000275)|BRCA - Breast invasive adenocarcinoma(234;0.00323)|Colorectal(3;0.0938)|KIRC - Kidney renal clear cell carcinoma(182;0.184)		CCCAGGAGATCGTTTCATCAT	0.448000			T	MLL	AL								20	6					0	0	1	0	0
SERPINB3	6317	broad.mit.edu	37	18	61326681	61326681	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:61326681C>T	ENST00000283752.5	-	4	446	c.303G>A	c.(301-303)ctG>ctA	p.L101L	SERPINB3_ENST00000332821.8_Silent_p.L101L|SERPINB11_ENST00000489748.1_RNA	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	101					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						TGGCGATCTTCAGCTCATATG	0.393000													42	66					0	0	1	0	0
ACOXL	55289	broad.mit.edu	37	2	111551725	111551725	+	Missense_Mutation	SNP	G	G	A	rs150003283	by1000genomes	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:111551725G>A	ENST00000389811.4	+	5	543	c.319G>A	c.(319-321)Gaa>Aaa	p.E107K	ACOXL_ENST00000439055.1_Missense_Mutation_p.E107K|ACOXL_ENST00000340561.4_Missense_Mutation_p.E107K			Q9NUZ1	ACOXL_HUMAN	acyl-CoA oxidase-like	107					fatty acid beta-oxidation	peroxisome	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity			kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)|skin(2)|urinary_tract(1)	21						GATCCAGACCGAAGCCACCTT	0.537000													28	38					0	0	1	0	0
POU2AF1	5450	broad.mit.edu	37	11	111228321	111228321	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:111228321C>T	ENST00000393067.3	-	4	819	c.305G>A	c.(304-306)tGg>tAg	p.W102*		NM_006235.2	NP_006226.2	Q16633	OBF1_HUMAN	POU class 2 associating factor 1	102					humoral immune response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	protein binding|transcription coactivator activity			breast(1)|kidney(2)|lung(2)	5		all_cancers(61;1.36e-12)|all_epithelial(67;1.87e-07)|Melanoma(852;1.46e-05)|Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0017)|all_neural(223;0.0146)|Medulloblastoma(222;0.0245)|Breast(348;0.0389)		Epithelial(105;1.01e-06)|BRCA - Breast invasive adenocarcinoma(274;3.12e-06)|all cancers(92;1.8e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0364)		GTAAGGTGTCCATGGGGCCAG	0.642000			T	BCL6	NHL								20	31					0	0	1	0	0
KRT79	338785	broad.mit.edu	37	12	53228033	53228033	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:53228033G>A	ENST00000330553.5	-	1	46	c.12C>T	c.(10-12)tcC>tcT	p.S4S		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	4	Head.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						GCCGAGAGACGGAGGACCTCA	0.617000													9	22					0	0	1	0	0
TMED8	283578	broad.mit.edu	37	14	77809809	77809809	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:77809809C>T	ENST00000216468.7	-	5	527	c.472G>A	c.(472-474)Gct>Act	p.A158T		NM_213601.1	NP_998766.1	Q6PL24	TMED8_HUMAN	transmembrane emp24 protein transport domain containing 8	158					transport	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)	15			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		CATGGAGGAGCCATCAGAGGT	0.527000													7	5					0	0	1	0	0
CATSPERD	257062	broad.mit.edu	37	19	5733876	5733876	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:5733876C>T	ENST00000381624.3	+	5	347	c.286C>T	c.(286-288)Cca>Tca	p.P96S	CATSPERD_ENST00000381614.2_5'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	96						integral to membrane											GGTCGGCGTACCAGAAGTGAC	0.343000													7	23					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108496528	108496528	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:108496528G>A	ENST00000408999.3	+	21	5106	c.5029G>A	c.(5029-5031)Gag>Aag	p.E1677K	RGPD4_ENST00000354986.4_Missense_Mutation_p.E1677K	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1677					intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						TCGGGAAGCAGAGGCAACCAG	0.453000													31	140					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44559838	44559838	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:44559838C>T	ENST00000332567.4	-	1	2150	c.1798G>A	c.(1798-1800)Gaa>Aaa	p.E600K	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	600	Activation domain (By similarity).				regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						GTTTTGTTTTCCTGTGGCTTT	0.493000													33	59					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41414557	41414557	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:41414557G>A	ENST00000400454.1	-	32	5904	c.5427C>T	c.(5425-5427)tcC>tcT	p.S1809S		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	1809					cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CTTCGTAAGTGGAGGAGGCAC	0.512000													24	43					0	0	1	0	0
ZNF768	79724	broad.mit.edu	37	16	30536228	30536228	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:30536228G>A	ENST00000380412.5	-	2	1408	c.1233C>T	c.(1231-1233)tcC>tcT	p.S411S	ZNF768_ENST00000562803.1_Silent_p.S380S	NM_024671.3	NP_078947.3	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	411					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						CCGACCGCTGGGAGAAGCTCT	0.657000													13	47					0	0	1	0	0
C10orf71	118461	broad.mit.edu	37	10	50531036	50531036	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:50531036C>T	ENST00000374144.3	+	3	734	c.446C>T	c.(445-447)tCt>tTt	p.S149F	C10orf71_ENST00000323868.4_Missense_Mutation_p.S149F			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	149										endometrium(1)	1						CTAATTAAATCTTTCGACAGG	0.537000													30	13					0	0	1	0	0
SLC9A2	6549	broad.mit.edu	37	2	103274201	103274201	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:103274201C>T	ENST00000233969.2	+	2	610	c.468C>T	c.(466-468)ttC>ttT	p.F156F		NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	156						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						CCGGCTATTTCATGCCCACTC	0.468000													93	146					0	0	1	0	0
TSHZ1	10194	broad.mit.edu	37	18	72999232	72999232	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:72999232C>T	ENST00000322038.5	+	2	2319	c.1735C>T	c.(1735-1737)Cca>Tca	p.P579S	TSHZ1_ENST00000580243.1_Missense_Mutation_p.P624S	NM_005786.5	NP_005777.3	Q6ZSZ6	TSH1_HUMAN	teashirt zinc finger homeobox 1	624						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(11)|liver(1)|lung(14)|ovary(1)|skin(6)|upper_aerodigestive_tract(2)	42		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CCTGCACTCCCCAGGGAGCCT	0.657000													27	35					0	0	1	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26422353	26422353	+	RNA	SNP	C	C	T	rs141013110		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:26422353C>T	ENST00000466808.2	+	0	7																		p.P3S(2)									GCTCATGGAACCAGCTGCTGC	0.622000													4	126					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176680981	176680981	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:176680981C>T	ENST00000367662.3	+	12	4826	c.3662C>T	c.(3661-3663)tCa>tTa	p.S1221L		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1221					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						ATTTGCACATCATACCATCCA	0.423000													11	83					0	0	1	0	0
SDK1	221935	broad.mit.edu	37	7	3861160	3861160	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:3861160G>A	ENST00000404826.2	+	5	931	c.792G>A	c.(790-792)gtG>gtA	p.V264V	SDK1_ENST00000389531.3_Silent_p.V264V	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	264	Ig-like C2-type 2.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TGCAGGCCGTGAATGAGAAAA	0.443000													30	57					0	0	1	0	0
KRT77	374454	broad.mit.edu	37	12	53086390	53086390	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:53086390C>T	ENST00000341809.3	-	7	1270	c.1242G>A	c.(1240-1242)gaG>gaA	p.E414E	RP11-641A6.3_ENST00000547533.1_RNA|KRT77_ENST00000537195.1_Silent_p.E181E	NM_175078.2	NP_778253.2	Q7Z794	K2C1B_HUMAN	keratin 77	414	Coil 2.|Rod.					keratin filament	structural molecule activity			NS(2)|endometrium(2)|large_intestine(3)|lung(11)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	25						CGCCTCTCTCCTCAGCATCCG	0.582000													30	27					0	0	1	0	0
OR5H2	79310	broad.mit.edu	37	3	98002054	98002054	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:98002054C>T	ENST00000355273.2	+	1	323	c.323C>T	c.(322-324)tCc>tTc	p.S108F	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005482.1	NP_001005482.1	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H, member 2	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						CAATTTTTTTCCTTTGCATTT	0.368000													39	62					0	0	1	0	0
PTPRT	11122	broad.mit.edu	37	20	41076952	41076952	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:41076952G>A	ENST00000373198.3	-	9	1703	c.1468C>T	c.(1468-1470)Cta>Tta	p.L490L	PTPRT_ENST00000373201.1_Silent_p.L490L|PTPRT_ENST00000373187.1_Silent_p.L490L|PTPRT_ENST00000373193.3_Silent_p.L490L|PTPRT_ENST00000373184.1_Silent_p.L490L|PTPRT_ENST00000373190.1_Silent_p.L490L|PTPRT_ENST00000356100.2_Silent_p.L490L	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	490	Fibronectin type-III 3.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				ATGGATTCTAGAGGAACAGCT	0.498000													55	87					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5410512	5410512	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:5410512G>A	ENST00000399537.4	-	11	4061	c.3713C>T	c.(3712-3714)cCc>cTc	p.P1238L	TNRC18_ENST00000430969.1_Missense_Mutation_p.P1238L			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1238							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GGCGGTGCAGGGTTCTGTCCG	0.697000													16	30					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167589702	167589702	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:167589702G>A	ENST00000519204.1	+	12	2264	c.2146G>A	c.(2146-2148)Ggg>Agg	p.G716R	TENM2_ENST00000545108.1_Missense_Mutation_p.G837R|TENM2_ENST00000518659.1_Missense_Mutation_p.G837R|TENM2_ENST00000403607.2_Missense_Mutation_p.G661R|CTB-178M22.1_ENST00000517408.1_RNA|TENM2_ENST00000520394.1_Missense_Mutation_p.G605R					teneurin transmembrane protein 2																		CGGCTGGAGAGGGCCCGGATG	0.557000													20	27					0	0	1	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84611351	84611351	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:84611351G>A	ENST00000286744.5	+	18	2345	c.2121G>A	c.(2119-2121)tgG>tgA	p.W707*	ADAMTSL3_ENST00000567476.1_Nonsense_Mutation_p.W707*	NM_207517.2	NP_997400.2	P82987	ATL3_HUMAN	ADAMTS-like 3	707	TSP type-1 5.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			NS(2)|breast(7)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(24)|lung(51)|ovary(7)|pancreas(2)|prostate(2)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	130			BRCA - Breast invasive adenocarcinoma(143;0.211)			GTTTTAGGTGGCATGTGGGCT	0.547000													24	22					0	0	1	0	0
TBX15	6913	broad.mit.edu	37	1	119427417	119427417	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:119427417C>T	ENST00000369429.3	-	8	1756	c.1747G>A	c.(1747-1749)Gat>Aat	p.D583N	TBX15_ENST00000207157.3_Missense_Mutation_p.D477N			Q96SF7	TBX15_HUMAN	T-box 15	583						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		TGCCGGCCATCACAAGTGTTG	0.557000													79	36					0	0	1	0	0
CRYGA	1418	broad.mit.edu	37	2	209025690	209025690	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:209025690G>A	ENST00000304502.4	-	3	382	c.363C>T	c.(361-363)atC>atT	p.I121I		NM_014617.3	NP_055432.2			crystallin, gamma A											endometrium(1)|kidney(3)|large_intestine(1)|lung(7)	12				Epithelial(149;0.067)|LUSC - Lung squamous cell carcinoma(261;0.0708)|Lung(261;0.135)		GGAGGGAATAGATCTCAGGGA	0.552000													42	70					0	0	1	0	0
CHD7	55636	broad.mit.edu	37	8	61765652	61765652	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:61765652C>T	ENST00000423902.2	+	31	6847	c.6368C>T	c.(6367-6369)tCc>tTc	p.S2123F	CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2123					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CCTGAGTTATCCTTCTTGGAT	0.502000													17	17					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136570043	136570043	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:136570043C>T	ENST00000264162.2	-	7	2201	c.2191G>A	c.(2191-2193)Ggg>Agg	p.G731R		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	731	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		CTCCTTATCCCCCAGGGCACC	0.512000													33	58					0	0	1	0	0
OR13H1	347468	broad.mit.edu	37	X	130678411	130678411	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:130678411C>T	ENST00000338616.3	+	1	462	c.364C>T	c.(364-366)Cgt>Tgt	p.R122C		NM_001004486.1	NP_001004486.1	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H, member 1	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15	Acute lymphoblastic leukemia(192;0.000636)					GGCCTATGACCGTGTGGTTGC	0.532000													63	10					0	0	1	0	0
C1S	716	broad.mit.edu	37	12	7172536	7172536	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:7172536C>T	ENST00000406697.1	+	9	1278	c.650C>T	c.(649-651)aCc>aTc	p.T217I	C1S_ENST00000328916.3_Missense_Mutation_p.T217I|C1S_ENST00000360817.5_Missense_Mutation_p.T217I|C1S_ENST00000402681.3_Missense_Mutation_p.T50I			P09871	C1S_HUMAN	complement component 1, s subcomponent	217	CUB 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(8)|liver(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	33					Abciximab(DB00054)|Adalimumab(DB00051)|Basiliximab(DB00074)|Cetuximab(DB00002)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Rituximab(DB00073)|Trastuzumab(DB00072)	GTGGTGGTGACCTTGCGGAGA	0.473000													21	56					0	0	1	0	0
INMT	11185	broad.mit.edu	37	7	30795280	30795280	+	Missense_Mutation	SNP	C	C	T	rs147878270	byFrequency	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:30795280C>T	ENST00000013222.5	+	3	621	c.605C>T	c.(604-606)cCg>cTg	p.P202L	INMT-FAM188B_ENST00000458257.1_Intron|INMT_ENST00000409539.1_Missense_Mutation_p.P201L|INMT_ENST00000484180.1_3'UTR	NM_001199219.1|NM_006774.4	NP_001186148.1|NP_006765.4	O95050	INMT_HUMAN	indolethylamine N-methyltransferase	202						cytoplasm	amine N-methyltransferase activity			kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(2)|stomach(1)	23						CTTCGGCTCCCGTCCTACATG	0.607000													34	47					0	0	1	0	0
AGK	55750	broad.mit.edu	37	7	141296383	141296383	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:141296383C>T	ENST00000355413.4	+	4	423	c.163C>T	c.(163-165)Cct>Tct	p.P55S	AGK_ENST00000535825.1_Missense_Mutation_p.P55S|AGK_ENST00000495028.1_3'UTR|AGK_ENST00000473247.1_Missense_Mutation_p.P27S	NM_018238.3	NP_060708.1	Q53H12	AGK_HUMAN	acylglycerol kinase	55					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway	mitochondrial membrane	acylglycerol kinase activity|ATP binding|diacylglycerol kinase activity|NAD+ kinase activity			breast(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(3)	17	Melanoma(164;0.0171)					TCAACTCATTCCTCCCAATGC	0.358000													39	42					0	0	1	0	0
GHR	2690	broad.mit.edu	37	5	42695177	42695177	+	Missense_Mutation	SNP	C	C	T	rs45501892		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:42695177C>T	ENST00000230882.4	+	5	615	c.425C>T	c.(424-426)tCt>tTt	p.S142F	GHR_ENST00000357703.3_Missense_Mutation_p.S120F|GHR_ENST00000537449.1_5'UTR	NM_000163.4|NM_001242399.2|NM_001242400.2|NM_001242401.3|NM_001242402.2|NM_001242403.2|NM_001242404.2|NM_001242405.2|NM_001242406.2	NP_000154.1|NP_001229328.1|NP_001229329.1|NP_001229330.1|NP_001229331.1|NP_001229332.1|NP_001229333.1|NP_001229334.1|NP_001229335.1	P10912	GHR_HUMAN	growth hormone receptor	142					2-oxoglutarate metabolic process|activation of JAK2 kinase activity|activation of MAPK activity|allantoin metabolic process|citrate metabolic process|creatine metabolic process|creatinine metabolic process|endocytosis|fatty acid metabolic process|growth hormone receptor signaling pathway|insulin-like growth factor receptor signaling pathway|isoleucine metabolic process|JAK-STAT cascade|multicellular organismal metabolic process|oxaloacetate metabolic process|positive regulation of multicellular organism growth|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|receptor internalization|response to cycloheximide|response to estradiol stimulus|succinate metabolic process|taurine metabolic process|valine metabolic process	cell surface|extracellular space|growth hormone receptor complex|integral to plasma membrane	growth factor binding|peptide hormone binding|proline-rich region binding|protein homodimerization activity|protein kinase binding			NS(2)|endometrium(2)|kidney(3)|large_intestine(8)|lung(19)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39		Myeloproliferative disorder(839;0.00878)			Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	AAGTGTTTCTCTGTTGATGAA	0.358000													11	36					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34090197	34090197	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:34090197G>A	ENST00000373381.4	-	35	5723	c.5547C>T	c.(5545-5547)tcC>tcT	p.S1849S	CSMD2_ENST00000373388.2_5'UTR|CSMD2_ENST00000373377.1_5'UTR|CSMD2_ENST00000373380.1_Silent_p.S722S	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	1809	CUB 11.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GGAAGCCAGGGGACAGGATGG	0.657000													21	134					0	0	1	0	0
HACL1	26061	broad.mit.edu	37	3	15621479	15621479	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:15621479G>A	ENST00000321169.5	-	9	1108	c.741C>T	c.(739-741)acC>acT	p.T247T	HACL1_ENST00000457447.2_Silent_p.T221T|HACL1_ENST00000435217.2_Intron|HACL1_ENST00000456194.2_Silent_p.T220T|HACL1_ENST00000451445.2_Silent_p.T165T	NM_012260.2	NP_036392.2	Q9UJ83	HACL1_HUMAN	2-hydroxyacyl-CoA lyase 1	247					fatty acid alpha-oxidation	peroxisomal matrix	carbon-carbon lyase activity|identical protein binding|magnesium ion binding|thiamine pyrophosphate binding			NS(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|skin(1)	16						TCCCCATAGGGGTGGGCAAAA	0.448000													32	43					0	0	1	0	0
TAS2R60	338398	broad.mit.edu	37	7	143140806	143140806	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:143140806C>T	ENST00000332690.1	+	1	261	c.261C>T	c.(259-261)ttC>ttT	p.F87F	EPHA1-AS1_ENST00000429289.1_RNA	NM_177437.1	NP_803186.1	P59551	T2R60_HUMAN	taste receptor, type 2, member 60	87					sensory perception of bitter taste	integral to membrane	G-protein coupled receptor activity			breast(1)|kidney(1)|large_intestine(2)|lung(17)|prostate(1)|skin(7)|urinary_tract(2)	31	Melanoma(164;0.172)					CGATGGCCTTCCCATACAACC	0.478000													26	83					0	0	1	0	0
SQRDL	58472	broad.mit.edu	37	15	45965857	45965857	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:45965857C>T	ENST00000260324.7	+	5	898	c.512C>T	c.(511-513)tCa>tTa	p.S171L	SQRDL_ENST00000568606.1_Missense_Mutation_p.S171L|RP11-96O20.4_ENST00000564080.1_Missense_Mutation_p.S171L	NM_021199.2	NP_067022.1	Q9Y6N5	SQRD_HUMAN	sulfide quinone reductase-like (yeast)	171							oxidoreductase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)	11		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		TCGAATTATTCAGTTAAGACT	0.413000													29	76					0	0	1	0	0
SIGLEC10	89790	broad.mit.edu	37	19	51918442	51918442	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:51918442G>A	ENST00000353836.5	-	7	1544	c.1323C>T	c.(1321-1323)tcC>tcT	p.S441S	SIGLEC10_ENST00000356298.5_Silent_p.S441S|SIGLEC10_ENST00000432469.2_Silent_p.S358S|SIGLEC10_ENST00000339313.5_Silent_p.S441S|SIGLEC10_ENST00000442846.3_Silent_p.S293S|SIGLEC10_ENST00000525998.1_Silent_p.S351S|SIGLEC10_ENST00000439889.2_Silent_p.S383S|SIGLEC10_ENST00000436984.2_Silent_p.S393S|SIGLEC10_ENST00000441969.3_Silent_p.S383S	NM_001171157.1|NM_001171158.1|NM_001171159.1	NP_001164628.1|NP_001164629.1|NP_001164630.1	Q96LC7	SIG10_HUMAN	sialic acid binding Ig-like lectin 10	441	Ig-like C2-type 3.				cell adhesion	extracellular region|integral to membrane|plasma membrane	sugar binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(27)|ovary(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000668)|OV - Ovarian serous cystadenocarcinoma(262;0.0101)		CACAGTGCACGGAGAGGCTGA	0.662000													20	51					0	0	1	0	0
CKAP2L	150468	broad.mit.edu	37	2	113509850	113509850	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:113509850G>A	ENST00000541405.1	-	5	1624	c.1101C>T	c.(1099-1101)atC>atT	p.I367I	CKAP2L_ENST00000302450.6_Silent_p.I532I			Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	532						centrosome				breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	28						TTACCCCTTCGATGAGGTTCA	0.368000													57	67					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13788937	13788937	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:13788937C>T	ENST00000265104.4	-	51	8639	c.8535G>A	c.(8533-8535)aaG>aaA	p.K2845K		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	2845					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TTACTAAAGCCTTATCAAACC	0.403000									Kartagener syndrome				28	15					0	0	1	0	0
FARSA	2193	broad.mit.edu	37	19	13035926	13035926	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:13035926G>A	ENST00000588025.1	-	9	1164	c.1024C>T	c.(1024-1026)Cag>Tag	p.Q342*	FARSA_ENST00000314606.4_Nonsense_Mutation_p.Q302*|FARSA_ENST00000423140.2_Nonsense_Mutation_p.Q271*			Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	302					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(3)|upper_aerodigestive_tract(1)	20					L-Phenylalanine(DB00120)	TAGCCGCCCTGAGAGTGGGTC	0.627000													6	8					0	0	1	0	0
RAI1	10743	broad.mit.edu	37	17	17701157	17701157	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:17701157C>T	ENST00000353383.1	+	3	5364	c.4895C>T	c.(4894-4896)tCc>tTc	p.S1632F	RAI1_ENST00000261641.6_Intron	NM_030665.3	NP_109590.3	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1632	Ser-rich.					cytoplasm|nucleus	zinc ion binding			breast(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(5)|urinary_tract(7)	48				READ - Rectum adenocarcinoma(1115;0.0276)		tcctctgcctcctcttcctca	0.647000													43	30					0	0	1	0	0
THSD7B	80731	broad.mit.edu	37	2	138000072	138000072	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:138000072C>T	ENST00000409968.1	+	10	2374	c.2196C>T	c.(2194-2196)ctC>ctT	p.L732L	THSD7B_ENST00000543459.1_Intron|THSD7B_ENST00000413152.2_Silent_p.L701L|THSD7B_ENST00000272643.3_Silent_p.L732L					thrombospondin, type I, domain containing 7B											NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		CCTGTTTTCTCCCATGCAAAA	0.473000													7	30					0	0	1	0	0
A1CF	29974	broad.mit.edu	37	10	52580390	52580390	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:52580390C>T	ENST00000395489.2	-	10	1164	c.768G>A	c.(766-768)aaG>aaA	p.K256K	A1CF_ENST00000282641.2_Silent_p.K263K|A1CF_ENST00000373993.1_Silent_p.K263K|A1CF_ENST00000493415.1_5'UTR|A1CF_ENST00000374001.1_Silent_p.K263K|A1CF_ENST00000395495.1_Silent_p.K208K|A1CF_ENST00000373997.3_Silent_p.K263K|A1CF_ENST00000373995.3_Silent_p.K271K	NM_001198819.1	NP_001185748.1	Q9NQ94	A1CF_HUMAN	APOBEC1 complementation factor	263	RRM 3.				cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			NS(1)|breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(14)|prostate(2)|skin(3)	29						CTCGAATTTTCTTCACCCTCT	0.383000													23	8					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85331160	85331160	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:85331160C>T	ENST00000440886.1	-	1	682	c.644G>A	c.(643-645)aGg>aAg	p.R215K	LPAR3_ENST00000491034.1_5'UTR|LPAR3_ENST00000370611.3_Missense_Mutation_p.R215K			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	215					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						GTTGGTTTTCCTCTTGACGTA	0.498000													46	23					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136567238	136567238	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:136567238G>A	ENST00000264162.2	-	8	2689	c.2679C>T	c.(2677-2679)ttC>ttT	p.F893F		NM_002299.2	NP_002290.2	P09848	LPH_HUMAN	lactase	893	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		AATCTCTTTCGAACTTGGGTT	0.522000													43	78					0	0	1	0	0
C3orf20	84077	broad.mit.edu	37	3	14803013	14803013	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:14803013C>T	ENST00000253697.3	+	15	2838	c.2386C>T	c.(2386-2388)Cgt>Tgt	p.R796C	C3orf20_ENST00000435614.1_Missense_Mutation_p.R674C|C3orf20_ENST00000412910.1_Missense_Mutation_p.R674C	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	796						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						TTTTGGGGGCCGTGTTTTGAA	0.498000													17	36					0	0	1	0	0
OR2G3	81469	broad.mit.edu	37	1	247769160	247769160	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:247769160G>A	ENST00000320002.2	+	1	305	c.273G>A	c.(271-273)acG>acA	p.T91T	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CAAAGAAGACGATCACTTACG	0.463000													217	82					0	0	1	0	0
CORO6	84940	broad.mit.edu	37	17	27946683	27946683	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:27946683C>T	ENST00000345068.5	-	3	520	c.307G>A	c.(307-309)Gac>Aac	p.D103N	RP11-68I3.2_ENST00000581474.1_RNA|CORO6_ENST00000584969.1_Missense_Mutation_p.D103N|CORO6_ENST00000577909.1_Intron|CORO6_ENST00000388767.3_Missense_Mutation_p.D103N|CORO6_ENST00000445145.2_Missense_Mutation_p.D103N|CORO6_ENST00000580212.1_Missense_Mutation_p.D103N			Q6QEF8	CORO6_HUMAN	coronin 6	103					actin cytoskeleton organization	actin cytoskeleton	actin filament binding			breast(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(4)|prostate(1)|urinary_tract(2)	14						ATGGTGGTGTCGTCTGAGGCA	0.577000													51	73					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126139164	126139164	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:126139164G>A	ENST00000299308.3	+	9	3153	c.3145G>A	c.(3145-3147)Gat>Aat	p.D1049N	TMEM132B_ENST00000535886.1_Missense_Mutation_p.D561N	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	1049						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		GTTTGACAGCGATGATAACAT	0.498000													12	47					0	0	1	0	0
TAS2R38	5726	broad.mit.edu	37	7	141672710	141672710	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:141672710G>A	ENST00000547270.1	-	1	863	c.780C>T	c.(778-780)tcC>tcT	p.S260S		NM_176817.4	NP_789787.4	P59533	T2R38_HUMAN	taste receptor, type 2, member 38	260					sensory perception of taste	integral to membrane	G-protein coupled receptor activity			NS(2)|breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)|stomach(1)	21	Melanoma(164;0.0171)					AGGCAGCACAGGATGATATCA	0.502000													27	40					0	0	1	0	0
LRTM1	57408	broad.mit.edu	37	3	54958924	54958924	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:54958924G>A	ENST00000273286.5	-	2	488	c.326C>T	c.(325-327)tCa>tTa	p.S109L	CACNA2D3_ENST00000474759.1_Intron|CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000490478.1_Intron|LRTM1_ENST00000493075.1_Missense_Mutation_p.S33L|CACNA2D3_ENST00000288197.5_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	109						integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		GGAAAGGAGTGAATTCTGGGT	0.468000													24	30					0	0	1	0	0
ITIH1	3697	broad.mit.edu	37	3	52825901	52825901	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:52825901G>A	ENST00000273283.2	+	22	2734	c.2710G>A	c.(2710-2712)Gat>Aat	p.D904N	ITIH1_ENST00000405128.3_Missense_Mutation_p.D270N|ITIH1_ENST00000542827.1_3'UTR|ITIH1_ENST00000540715.1_Missense_Mutation_p.D762N|ITIH1_ENST00000537050.1_Missense_Mutation_p.D616N	NM_002215.3	NP_002206.2	P19827	ITIH1_HUMAN	inter-alpha-trypsin inhibitor heavy chain 1	904	Hyaluronan-binding.				hyaluronan metabolic process|leukocyte activation	extracellular region	calcium ion binding|serine-type endopeptidase inhibitor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(16)|lung(18)|ovary(4)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	52				BRCA - Breast invasive adenocarcinoma(193;7.04e-05)|Kidney(197;0.000659)|KIRC - Kidney renal clear cell carcinoma(197;0.000795)|OV - Ovarian serous cystadenocarcinoma(275;0.0498)		TGCCTACACTGATTATATCGT	0.587000													27	30					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29126062	29126062	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:29126062G>A	ENST00000261590.8	+	15	2922	c.2713G>A	c.(2713-2715)Gaa>Aaa	p.E905K	RP11-75N4.2_ENST00000583706.1_RNA	NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	905					cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding	p.E905K(1)		breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			AGTAACTCAGGAAATAGTCAC	0.433000													31	51					0	0	1	0	0
PLXNC1	10154	broad.mit.edu	37	12	94562988	94562988	+	Silent	SNP	C	C	T	rs150683869	byFrequency	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:94562988C>T	ENST00000258526.4	+	2	1371	c.1122C>T	c.(1120-1122)tcC>tcT	p.S374S	RP11-74K11.2_ENST00000551029.1_RNA|RP11-74K11.2_ENST00000550759.1_RNA	NM_005761.2	NP_005752.1	O60486	PLXC1_HUMAN	plexin C1	374	Sema.				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(12)|lung(30)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						TGATCCATTCCGACCTGACAT	0.423000													8	36					0	0	1	0	0
INTS1	26173	broad.mit.edu	37	7	1535135	1535135	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:1535135G>A	ENST00000389470.4	-	14	2149	c.2150C>T	c.(2149-2151)gCc>gTc	p.A717V	INTS1_ENST00000404767.3_Missense_Mutation_p.A589V			Q8N201	INT1_HUMAN	integrator complex subunit 1	589					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CCACCAGACGGCATCCCGCTG	0.627000													11	26					0	0	1	0	0
UNC79	57578	broad.mit.edu	37	14	94007025	94007025	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:94007025T>A	ENST00000553484.1	+	13	1526	c.1372T>A	c.(1372-1374)Ttc>Atc	p.F458I	UNC79_ENST00000256339.4_Missense_Mutation_p.F281I|UNC79_ENST00000393151.2_Missense_Mutation_p.F458I|UNC79_ENST00000555664.1_Missense_Mutation_p.F458I			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	458						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						AGAAGCCGAGTTCCATGCTGA	0.488000													39	15					0	0	1	0	0
FTH1P3	2498	broad.mit.edu	37	5	17354459	17354459	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:17354459G>A	ENST00000511821.1	+	0	318				FTH1P10_ENST00000401830.3_RNA																							GCTCCAGGTTGATCTGGCGGT	0.562000													14	39					0	0	1	0	0
C8orf34	116328	broad.mit.edu	37	8	69434172	69434172	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:69434172G>A	ENST00000337103.4	+	5	2163	c.571G>A	c.(571-573)Gaa>Aaa	p.E191K	C8orf34_ENST00000348340.2_Missense_Mutation_p.E216K|C8orf34_ENST00000349492.3_3'UTR|C8orf34_ENST00000539993.1_Missense_Mutation_p.E216K|C8orf34_ENST00000518698.1_Missense_Mutation_p.E302K			Q49A92	CH034_HUMAN	chromosome 8 open reading frame 34	216					signal transduction		cAMP-dependent protein kinase regulator activity			NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(12)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	36			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			TGACCAATGGGAAAGTGAAGA	0.418000													18	30					0	0	1	0	0
AADACL2-AS1	101928142	broad.mit.edu	37	3	151501972	151501972	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:151501972C>T	ENST00000483843.2	-	0	439				RP11-454C18.2_ENST00000475855.1_RNA|RP11-64D22.2_ENST00000483636.1_RNA																							TGAGGGCAGCCCCTTTGTTGG	0.423000													7	6					0	0	1	0	0
OR10X1	128367	broad.mit.edu	37	1	158548752	158548752	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:158548752G>A	ENST00000368150.1	-	1	937	c.938C>T	c.(937-939)gCt>gTt	p.A313V		NM_001004477.1	NP_001004477.1	Q8NGY0	O10X1_HUMAN	olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene)	313					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(2)|large_intestine(6)|lung(22)|ovary(2)|skin(2)|urinary_tract(1)	37	all_hematologic(112;0.0378)					TCTTCTAAAAGCATTTTTCAT	0.433000													21	134					0	0	1	0	0
HS6ST1	9394	broad.mit.edu	37	2	129026036	129026036	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:129026036G>A	ENST00000259241.6	-	2	949	c.936C>T	c.(934-936)ttC>ttT	p.F312F		NM_004807.2	NP_004798.3	O60243	H6ST1_HUMAN	heparan sulfate 6-O-sulfotransferase 1	312					heparan sulfate proteoglycan biosynthetic process, enzymatic modification	integral to plasma membrane	sulfotransferase activity			endometrium(3)|liver(1)|lung(7)|pancreas(1)|prostate(2)|skin(1)	15	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.117)		AGGGCCGGATGAACTTGAGGT	0.612000													22	14					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57327228	57327228	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:57327228G>A	ENST00000326441.9	-	10	2945	c.2582C>T	c.(2581-2583)tCc>tTc	p.S861F	ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000593695.1_Missense_Mutation_p.S735F|PEG3_ENST00000598410.1_Missense_Mutation_p.S737F|PEG3_ENST00000423103.2_Missense_Mutation_p.S861F|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000221722.5_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	861					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		ATAAATGGAGGATTCTCCCTT	0.428000													27	25					0	0	1	0	0
PTPN14	5784	broad.mit.edu	37	1	214557039	214557039	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:214557039G>A	ENST00000366956.5	-	13	2353	c.2159C>T	c.(2158-2160)tCg>tTg	p.S720L	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	720					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding	p.S720L(1)		NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		CTGGGGCACCGATTCTGGAGC	0.622000													50	22					0	0	1	0	0
ASXL3	80816	broad.mit.edu	37	18	31251711	31251711	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:31251711G>A	ENST00000269197.5	+	7	596	c.595_splice	c.e7-1	p.G199_splice		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	199					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						CCTTTTTTAGGATCTGAATCT	0.323000													10	12					0	0	1	0	0
TENM1	10178	broad.mit.edu	37	X	123657311	123657311	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:123657311G>A	ENST00000422452.2	-	17	2999	c.2936C>T	c.(2935-2937)tCc>tTc	p.S979F	TENM1_ENST00000371130.3_Missense_Mutation_p.S979F	NM_001163278.1|NM_001163279.1	NP_001156750.1|NP_001156751.1			teneurin transmembrane protein 1																		GATAAAGTTGGAGATATCGCA	0.493000													51	11					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50273611	50273611	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:50273611C>T	ENST00000338821.5	-	14	1636	c.1372G>A	c.(1372-1374)Gaa>Aaa	p.E458K	ATP9A_ENST00000402822.1_Missense_Mutation_p.E337K|ATP9A_ENST00000311637.5_Missense_Mutation_p.E322K	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	458					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						TTCACGGCTTCGTGCACGCGG	0.597000													11	60					0	0	1	0	0
ZNF274	10782	broad.mit.edu	37	19	58718128	58718128	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:58718128C>T	ENST00000326804.4	+	5	757	c.298C>T	c.(298-300)Cct>Tct	p.P100S	ZNF274_ENST00000424679.2_5'UTR|ZNF274_ENST00000597818.1_3'UTR|ZNF274_ENST00000345813.3_Missense_Mutation_p.P68S	NM_133502.1	NP_598009.1	Q96GC6	ZN274_HUMAN	zinc finger protein 274	100					viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)|skin(1)	21		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		GGATCCTCTTCCTGCTGAGAG	0.502000													5	7					0	0	1	0	0
IGKV1-17	28937	broad.mit.edu	37	2	89417306	89417306	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:89417306C>T	ENST00000490686.1	-	0	29																											CCCTCATGTCCATGCTGTGTC	0.547000													57	141					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124339333	124339333	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:124339333G>A	ENST00000338354.3	+	10	1025	c.919G>A	c.(919-921)Gag>Aag	p.E307K	DMBT1_ENST00000344338.3_Missense_Mutation_p.E307K|DMBT1_ENST00000368955.3_Missense_Mutation_p.E307K|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000330163.4_Missense_Mutation_p.E307K|DMBT1_ENST00000368909.3_Missense_Mutation_p.E307K|DMBT1_ENST00000368956.2_Missense_Mutation_p.E307K			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	307	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CTCAGGACATGAGTCCTACCT	0.602000													36	77					0	0	1	0	0
BCOR	54880	broad.mit.edu	37	X	39934346	39934346	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:39934346G>A	ENST00000342274.4	-	4	615	c.253C>T	c.(253-255)Ccg>Tcg	p.P85S	BCOR_ENST00000378444.4_Missense_Mutation_p.P85S|BCOR_ENST00000378455.4_Missense_Mutation_p.P85S|BCOR_ENST00000397354.3_Missense_Mutation_p.P85S	NM_001123383.1	NP_001116855.1	Q6W2J9	BCOR_HUMAN	BCL6 corepressor	85			P -> L (in MCOPS2; dbSNP:rs28935183).		heart development|histone H2A monoubiquitination|negative regulation of bone mineralization|negative regulation of histone H3-K36 methylation|negative regulation of histone H3-K4 methylation|negative regulation of tooth mineralization|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|specification of axis polarity|transcription, DNA-dependent	nucleus	heat shock protein binding|histone deacetylase binding|transcription corepressor activity|transcription factor binding|transcription regulatory region DNA binding			breast(4)|central_nervous_system(11)|cervix(1)|endometrium(24)|eye(6)|haematopoietic_and_lymphoid_tissue(33)|kidney(2)|large_intestine(11)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	126						ATGTTTCCCGGGACCCGCAGC	0.587000			"""F, N, S, T"""	RARA	"""retinoblastoma, AML, APL(translocation)"""		oculo-facio-cardio-dental genetic						17	7					0	0	1	0	0
ACR	49	broad.mit.edu	37	22	51178266	51178266	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:51178266C>T	ENST00000216139.5	+	3	466	c.426C>T	c.(424-426)gaC>gaT	p.D142D	ACR_ENST00000529621.1_Silent_p.D142D	NM_001097.2	NP_001088.2	P10323	ACRO_HUMAN	acrosin	142	Peptidase S1.				acrosome matrix dispersal|activation of adenylate cyclase activity	acrosomal matrix|protein complex	amidase activity|copper ion binding|DNA binding|drug binding|fucose binding|mannose binding|protein binding|serine-type endopeptidase activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	7		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;1.1e-06)|LUAD - Lung adenocarcinoma(64;0.247)		AGGGAAATGACATTGCCCTCG	0.522000													49	20					0	0	1	0	0
PLBD1	79887	broad.mit.edu	37	12	14688711	14688711	+	Silent	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:14688711A>G	ENST00000240617.5	-	6	1378	c.726T>C	c.(724-726)ctT>ctC	p.L242L		NM_024829.5	NP_079105.4	Q6P4A8	PLBL1_HUMAN	phospholipase B domain containing 1	242					lipid catabolic process	extracellular region	hydrolase activity			central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(3)|prostate(1)|upper_aerodigestive_tract(1)	16						AGTGAGCAAAAAGGATGTTCT	0.428000													12	54					0	0	1	0	0
DUSP27	92235	broad.mit.edu	37	1	167097756	167097756	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:167097756G>A	ENST00000361200.2	+	6	3554	c.3388G>A	c.(3388-3390)Gaa>Aaa	p.E1130K	DUSP27_ENST00000485151.1_Intron|DUSP27_ENST00000443333.1_Missense_Mutation_p.E1130K|DUSP27_ENST00000271385.5_Missense_Mutation_p.E1130K			Q5VZP5	DUS27_HUMAN	dual specificity phosphatase 27 (putative)	1130					protein dephosphorylation		protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(11)|liver(1)|lung(46)|ovary(5)|prostate(5)|skin(4)|upper_aerodigestive_tract(3)	89						GGAGGAAGAGGAAGAAATGGA	0.527000													31	15					0	0	1	0	0
GSDMC	56169	broad.mit.edu	37	8	130761728	130761728	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:130761728C>T	ENST00000276708.4	-	13	2138	c.1257G>A	c.(1255-1257)gaG>gaA	p.E419E		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	419						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						GGATCCTCTTCTCCATGGAAC	0.517000													19	25					0	0	1	0	0
FUT2	2524	broad.mit.edu	37	19	49206492	49206492	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:49206492C>T	ENST00000425340.2	+	2	396	c.279C>T	c.(277-279)gcC>gcT	p.A93A	FUT2_ENST00000391876.4_Silent_p.A93A	NM_000511.5|NM_001097638.2	NP_000502.4|NP_001091107.1	Q10981	FUT2_HUMAN	fucosyltransferase 2 (secretor status included)	93					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	galactoside 2-alpha-L-fucosyltransferase activity			breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(1)|lung(2)	7		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.00011)|all cancers(93;0.000238)|GBM - Glioblastoma multiforme(486;0.0164)|Epithelial(262;0.017)		GGCGGCCCGCCTTCATCCCGG	0.647000													10	35					0	0	1	0	0
MTMR7	9108	broad.mit.edu	37	8	17218703	17218703	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:17218703C>T	ENST00000180173.5	-	4	425	c.391G>A	c.(391-393)Gat>Aat	p.D131N	MTMR7_ENST00000521857.1_Missense_Mutation_p.D131N	NM_004686.4	NP_004677.3	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	131	Myotubularin phosphatase.						protein tyrosine phosphatase activity			breast(1)|endometrium(5)|kidney(2)|large_intestine(5)|liver(1)|lung(8)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	32				Colorectal(111;0.112)		TCACTAAGATCGATCAGCACC	0.453000													27	37					0	0	1	0	0
PROKR2	128674	broad.mit.edu	37	20	5294689	5294689	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:5294689G>A	ENST00000546004.1	-	2	573	c.327C>T	c.(325-327)ttC>ttT	p.F109F	PROKR2_ENST00000217270.3_Silent_p.F109F			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	109						integral to membrane|plasma membrane	neuropeptide Y receptor activity	p.F109L(1)		autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						AGTCCATCTCGAAGGGGCAGC	0.592000										HNSCC(71;0.22)			39	39					0	0	1	0	0
C1orf173	127254	broad.mit.edu	37	1	75038517	75038517	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:75038517C>T	ENST00000326665.5	-	14	3095	c.2877G>A	c.(2875-2877)atG>atA	p.M959I	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	959	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CTGTGTCCTCCATGGGTCCTG	0.527000													16	112					0	0	1	0	0
HCRTR2	3062	broad.mit.edu	37	6	55113483	55113483	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:55113483C>T	ENST00000370862.3	+	2	606	c.270C>T	c.(268-270)aaC>aaT	p.N90N		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	90					feeding behavior	integral to plasma membrane	neuropeptide receptor activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			CGGTAACCAACTACTTCATAG	0.448000													84	56					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92495273	92495273	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:92495273C>T	ENST00000298047.6	+	4	3938	c.3921C>T	c.(3919-3921)gaC>gaT	p.D1307D	FAT3_ENST00000409404.2_Silent_p.D1307D|RP11-203F8.1_ENST00000529884.1_RNA|FAT3_ENST00000525166.1_Silent_p.D1157D			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1307	Cadherin 12.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				TCTTTATTGACCCTAAAACTG	0.448000										TCGA Ovarian(4;0.039)			32	47					0	0	1	0	0
KRT86	3892	broad.mit.edu	37	12	52699530	52699530	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:52699530G>A	ENST00000293525.5	+	6	1036	c.984G>A	c.(982-984)atG>atA	p.M328I	KRT86_ENST00000544024.1_Missense_Mutation_p.M328I|KRT86_ENST00000423955.2_Missense_Mutation_p.M328I	NM_002284.3	NP_002275.1	O43790	KRT86_HUMAN	keratin 86	328	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|cervix(1)|large_intestine(1)|lung(5)|ovary(1)|skin(1)	10				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGAACCGCATGATCCAGAGGC	0.592000													25	56					0	0	1	0	0
PEG3	5178	broad.mit.edu	37	19	57335704	57335704	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:57335704C>T	ENST00000326441.9	-	4	683	c.320G>A	c.(319-321)cGa>cAa	p.R107Q	ZIM2_ENST00000601070.1_5'UTR|ZIM2_ENST00000599935.1_5'UTR|PEG3_ENST00000593695.1_5'UTR|PEG3_ENST00000594706.1_5'UTR|PEG3_ENST00000598410.1_5'UTR|PEG3_ENST00000423103.2_Missense_Mutation_p.R107Q|ZIM2_ENST00000391708.3_5'UTR|ZIM2_ENST00000593711.1_5'UTR|ZIM2_ENST00000221722.5_5'UTR	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	107	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.R107Q(2)		NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CTTTTTTGCTCGCACCCAAGG	0.542000													33	50					0	0	1	0	0
ATF4P4	100127952	broad.mit.edu	37	11	113660984	113660984	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:113660984C>T	ENST00000393544.2	+	0	1032																											TTGCTGTAACCGACAAAGACA	0.582000													6	21					0	0	1	0	0
OR1D2	4991	broad.mit.edu	37	17	2996169	2996169	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:2996169C>T	ENST00000331459.1	-	1	121	c.122G>A	c.(121-123)gGa>gAa	p.G41E		NM_002548.2	NP_002539.2	P34982	OR1D2_HUMAN	olfactory receptor, family 1, subfamily D, member 2	41					cellular component movement|chemotaxis|protein import into nucleus, translocation|sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(2)|lung(10)|ovary(1)	15						GAGCACATTTCCCACCACCGT	0.547000													47	27					0	0	1	0	0
PARP8	79668	broad.mit.edu	37	5	50117055	50117055	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:50117055T>A	ENST00000281631.5	+	16	1835	c.1677T>A	c.(1675-1677)gaT>gaA	p.D559E	PARP8_ENST00000503750.2_Intron|PARP8_ENST00000505554.1_Missense_Mutation_p.D538E|PARP8_ENST00000505697.2_Missense_Mutation_p.D559E|PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000514067.2_Intron|PARP8_ENST00000514342.2_Intron	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	559						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				AGGTGGTAGATCTACTAGTAT	0.398000													17	36					0	0	1	0	0
FYB	2533	broad.mit.edu	37	5	39134989	39134989	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:39134989C>T	ENST00000351578.6	-	8	1833	c.1643G>A	c.(1642-1644)gGa>gAa	p.G548E	FYB_ENST00000512982.1_Missense_Mutation_p.G548E|FYB_ENST00000515010.1_Missense_Mutation_p.G548E|FYB_ENST00000540520.1_Missense_Mutation_p.G558E|FYB_ENST00000505428.1_Missense_Mutation_p.G548E	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	548	SH3.				cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			CAACCATTTTCCTTCTGGGTT	0.418000													29	46					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7556302	7556302	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:7556302G>A	ENST00000313599.3	-	6	1294	c.1237C>T	c.(1237-1239)Ccg>Tcg	p.P413S	CD163L1_ENST00000396630.1_Missense_Mutation_p.P413S|CD163L1_ENST00000416109.2_Missense_Mutation_p.P423S			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	413	SRCR 4.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						ACGCTGAACGGACATCCTAGC	0.458000													43	50					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003902	122003902	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:122003902G>A	ENST00000498619.1	+	7	3569	c.3131G>A	c.(3130-3132)gGa>gAa	p.G1044E	CASR_ENST00000490131.1_Missense_Mutation_p.G1034E|CASR_ENST00000296154.5_Missense_Mutation_p.G1034E	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	1034					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GGTCTGCAAGGACCTGTGGGT	0.572000													34	50					0	0	1	0	0
PCDHGB3	56102	broad.mit.edu	37	5	140751497	140751497	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140751497G>A	ENST00000576222.1	+	1	1667	c.1536G>A	c.(1534-1536)ggG>ggA	p.G512G	PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB1_ENST00000523390.1_Intron	NM_018924.2|NM_032097.1	NP_061747.1|NP_115268.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCGGAGCGGGGTGGTGTTCG	0.672000													41	58					0	0	1	0	0
PLD5	200150	broad.mit.edu	37	1	242451697	242451697	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:242451697C>T	ENST00000442594.2	-	4	695	c.186G>A	c.(184-186)tgG>tgA	p.W62*	PLD5_ENST00000536534.1_Nonsense_Mutation_p.W154*|PLD5_ENST00000427495.1_Nonsense_Mutation_p.W92*	NM_152666.2	NP_689879.2	Q8N7P1	PLD5_HUMAN	phospholipase D family, member 5	154						integral to membrane	catalytic activity			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(22)|ovary(6)|skin(3)|urinary_tract(1)	55	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			GGTTGAGATCCCAATGGGAAG	0.403000													19	96					0	0	1	0	0
WDR6	11180	broad.mit.edu	37	3	49049488	49049488	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:49049488C>T	ENST00000395474.3	+	2	891	c.611C>T	c.(610-612)aCc>aTc	p.T204I	WDR6_ENST00000489684.1_3'UTR|WDR6_ENST00000415265.2_Intron|WDR6_ENST00000448293.1_Missense_Mutation_p.T123I	NM_018031.3	NP_060501.3	Q9NNW5	WDR6_HUMAN	WD repeat domain 6	174					cell cycle arrest|negative regulation of cell proliferation	cytoplasm				breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|liver(1)|lung(9)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		AAGGAGCTGACCATAGTGGCA	0.562000													14	22					0	0	1	0	0
CCDC60	160777	broad.mit.edu	37	12	119957972	119957972	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:119957972G>A	ENST00000327554.2	+	9	1480	c.1015G>A	c.(1015-1017)Gaa>Aaa	p.E339K	RP11-768F21.1_ENST00000509470.2_lincRNA	NM_178499.3	NP_848594.2	Q8IWA6	CCD60_HUMAN	coiled-coil domain containing 60	339										endometrium(4)|kidney(3)|large_intestine(8)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.207)		TGCTTATAAGGAAATGCAGAC	0.483000													38	96					0	0	1	0	0
PTPRK	5796	broad.mit.edu	37	6	128330313	128330313	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:128330313G>A	ENST00000368227.3	-	14	2661	c.2295C>T	c.(2293-2295)atC>atT	p.I765I	PTPRK_ENST00000368210.3_Silent_p.I765I|PTPRK_ENST00000524481.1_5'UTR|PTPRK_ENST00000368207.3_Silent_p.I765I|PTPRK_ENST00000368226.4_Silent_p.I765I|PTPRK_ENST00000532331.1_Silent_p.I765I|PTPRK_ENST00000368213.5_Silent_p.I765I|PTPRK_ENST00000368215.3_Silent_p.I764I			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	764					cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		GGAGAAGGAGGATGAACACCA	0.418000													20	63					0	0	1	0	0
RBBP8NL	140893	broad.mit.edu	37	20	60991839	60991839	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:60991839T>A	ENST00000252998.1	-	5	446	c.290A>T	c.(289-291)aAc>aTc	p.N97I		NM_080833.2	NP_543023.2			RBBP8 N-terminal like																		GCGCTGCAGGTTCTGCAGGTG	0.677000													3	12					0	0	1	0	0
PCDH1	5097	broad.mit.edu	37	5	141242887	141242887	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:141242887G>A	ENST00000287008.3	-	3	3156	c.3009C>T	c.(3007-3009)ttC>ttT	p.F1003F	PCDH1_ENST00000511044.1_5'UTR|PCDH1_ENST00000394536.3_Silent_p.F1003F|PCDH1_ENST00000456271.1_Silent_p.F991F|PCDH1_ENST00000503492.1_Intron|PCDH1_ENST00000536585.1_Silent_p.F981F	NM_032420.2	NP_115796.2	Q08174	PCDH1_HUMAN	protocadherin 1	1003					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(4)|lung(20)|ovary(5)|skin(3)|upper_aerodigestive_tract(1)	51		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		CGGTGCCCACGAATGTGTTTG	0.622000													14	28					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124345791	124345791	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:124345791G>A	ENST00000338354.3	+	16	1781	c.1675G>A	c.(1675-1677)Gat>Aat	p.D559N	DMBT1_ENST00000344338.3_Missense_Mutation_p.D549N|DMBT1_ENST00000368955.3_Missense_Mutation_p.D549N|DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000368909.3_Missense_Mutation_p.D559N|DMBT1_ENST00000368956.2_Intron			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	559	SRCR 4.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CATTGTCCTGGATGACGTGCG	0.587000													92	55					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41711173	41711173	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:41711173C>T	ENST00000400454.1	-	7	1857	c.1380G>A	c.(1378-1380)acG>acA	p.T460T		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	460	Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TCCCCTCCGACGTGATCATCT	0.612000													34	31					0	0	1	0	0
KIAA1804	84451	broad.mit.edu	37	1	233515161	233515161	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:233515161C>T	ENST00000366624.3	+	9	2670	c.2409C>T	c.(2407-2409)tcC>tcT	p.S803S	MLK4_ENST00000366622.1_Silent_p.S249S	NM_032435.2	NP_115811.2																					GCATCCTCTCCACACCTTCTT	0.607000													15	100					0	0	1	0	0
SLC6A1	6529	broad.mit.edu	37	3	11070523	11070523	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:11070523T>C	ENST00000287766.4	+	11	1602	c.1181T>C	c.(1180-1182)aTt>aCt	p.I394T	SLC6A1_ENST00000536032.1_Missense_Mutation_p.I216T	NM_003042.3	NP_003033.3	P30531	SC6A1_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 1	394					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			breast(1)|endometrium(2)|large_intestine(6)|lung(6)|ovary(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	26		Ovarian(110;0.0392)		OV - Ovarian serous cystadenocarcinoma(96;0.00099)	Cocaine(DB00907)|Tiagabine(DB00906)	ATGCTGGGCATTGACAGCCAG	0.637000													18	28					0	0	1	0	0
ITGBL1	9358	broad.mit.edu	37	13	102235631	102235631	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:102235631C>T	ENST00000376180.3	+	6	1012	c.793C>T	c.(793-795)Cat>Tat	p.H265Y	ITGBL1_ENST00000376162.3_Missense_Mutation_p.H172Y|ITGBL1_ENST00000545560.2_Missense_Mutation_p.H124Y	NM_001271756.1|NM_004791.1	NP_001258685.1|NP_004782.1	O95965	ITGBL_HUMAN	integrin, beta-like 1 (with EGF-like repeat domains)	265	Cysteine-rich tandem repeats.				cell-matrix adhesion|integrin-mediated signaling pathway	extracellular region|integrin complex	binding|receptor activity			breast(1)|large_intestine(6)|lung(16)|ovary(1)|prostate(4)|skin(3)	31	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GGGAGATATTCATGGGGACAC	0.458000													94	87					0	0	1	0	0
CASZ1	54897	broad.mit.edu	37	1	10711037	10711037	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:10711037G>A	ENST00000377022.3	-	12	3094	c.2777C>T	c.(2776-2778)tCc>tTc	p.S926F	RP4-734G22.3_ENST00000606802.1_RNA|CASZ1_ENST00000344008.5_Missense_Mutation_p.S926F	NM_001079843.1	NP_001073312.1	Q86V15	CASZ1_HUMAN	castor zinc finger 1	926					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|large_intestine(13)|lung(18)|ovary(2)|prostate(5)|skin(2)|urinary_tract(1)	54	Ovarian(185;0.203)|all_lung(157;0.204)	Lung NSC(185;4.96e-06)|all_lung(284;1.22e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00212)|Hepatocellular(190;0.00913)|Ovarian(437;0.0229)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0224)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0265)|Colorectal(212;3.54e-08)|COAD - Colon adenocarcinoma(227;9.56e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000219)|Kidney(185;0.00142)|KIRC - Kidney renal clear cell carcinoma(229;0.00381)|READ - Rectum adenocarcinoma(331;0.0419)|STAD - Stomach adenocarcinoma(132;0.0623)		GCGGTCCTGGGAGGCTTCGTG	0.706000													30	19					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	101847244	101847244	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:101847244G>A	ENST00000369138.1	+	1	581	c.91G>A	c.(91-93)Gga>Aga	p.G31R	GRIK2_ENST00000369137.3_Missense_Mutation_p.G31R|GRIK2_ENST00000421544.1_Missense_Mutation_p.G31R|GRIK2_ENST00000318991.6_Missense_Mutation_p.G31R|GRIK2_ENST00000413795.1_Missense_Mutation_p.G31R|GRIK2_ENST00000358361.3_Missense_Mutation_p.G31R	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	31					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	ATATTCTCAAGGAACCACACA	0.468000													9	85					0	0	1	0	0
CABIN1	23523	broad.mit.edu	37	22	24463103	24463103	+	Nonsense_Mutation	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:24463103G>T	ENST00000398319.2	+	16	2588	c.2203G>T	c.(2203-2205)Gag>Tag	p.E735*	CABIN1_ENST00000263119.5_Nonsense_Mutation_p.E735*|CABIN1_ENST00000405822.2_Nonsense_Mutation_p.E685*	NM_001199281.1	NP_001186210.1	Q9Y6J0	CABIN_HUMAN	calcineurin binding protein 1	735					cell surface receptor linked signaling pathway|chromatin modification	nucleus	protein phosphatase inhibitor activity			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(13)|liver(1)|lung(18)|ovary(5)|pancreas(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	65						TTCCATTCCTGAGAGGCCAGC	0.547000													16	27					1.15088e-07	1.15644e-07	1	1	0
PDE1B	5153	broad.mit.edu	37	12	54968997	54968997	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:54968997C>T	ENST00000243052.3	+	11	1616	c.1180C>T	c.(1180-1182)Cgt>Tgt	p.R394C	PDE1B_ENST00000538346.1_Missense_Mutation_p.R353C|PDE1B_ENST00000394277.3_3'UTR|PDE1B_ENST00000550620.1_Missense_Mutation_p.R374C	NM_000924.3	NP_000915.1	Q01064	PDE1B_HUMAN	phosphodiesterase 1B, calmodulin-dependent	394	Catalytic (By similarity).				activation of phospholipase C activity|apoptosis|nerve growth factor receptor signaling pathway|platelet activation	cytosol|nucleus	3',5'-cyclic-AMP phosphodiesterase activity|calmodulin binding|calmodulin-dependent cyclic-nucleotide phosphodiesterase activity|metal ion binding			endometrium(1)|kidney(3)|large_intestine(4)|lung(16)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(4)	31						GGAATTCTTCCGTCAGGTAGC	0.572000													19	58					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	167760381	167760381	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:167760381C>T	ENST00000409195.1	+	2	478	c.389C>T	c.(388-390)cCa>cTa	p.P130L	XIRP2_ENST00000409728.1_Missense_Mutation_p.P130L|XIRP2_ENST00000295237.9_Missense_Mutation_p.P130L|XIRP2_ENST00000409756.2_Missense_Mutation_p.P130L|XIRP2_ENST00000420519.1_Missense_Mutation_p.P130L|XIRP2_ENST00000409043.1_Missense_Mutation_p.P130L	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	0					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GGAAACAAACCAGCTGAGTAC	0.458000													34	55					0	0	1	0	0
CCDC88A	55704	broad.mit.edu	37	2	55566639	55566639	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:55566639G>A	ENST00000436346.1	-	13	2320	c.1479C>T	c.(1477-1479)atC>atT	p.I493I	AC012358.8_ENST00000594078.1_RNA|AC012358.8_ENST00000599352.1_RNA|AC012358.8_ENST00000599475.1_RNA|AC012358.8_ENST00000600219.1_RNA|CCDC88A_ENST00000263630.8_Silent_p.I493I|CCDC88A_ENST00000413716.2_Silent_p.I493I|CCDC88A_ENST00000336838.6_Silent_p.I493I	NM_001135597.1|NM_001254943.1	NP_001129069.1|NP_001241872.1	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A	493					activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(22)|lung(23)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|urinary_tract(1)	69						CCATTTTCAGGATTTTGGAAG	0.299000													8	9					0	0	1	0	0
TMEM225	338661	broad.mit.edu	37	11	123753976	123753976	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:123753976C>T	ENST00000375026.2	-	4	763	c.547G>A	c.(547-549)Gaa>Aaa	p.E183K		NM_001013743.1	NP_001013765.1	Q6GV28	TM225_HUMAN	transmembrane protein 225	183						integral to membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	28						TTCTCAGATTCCTTACATTCG	0.423000													20	41					0	0	1	0	0
RBM26	64062	broad.mit.edu	37	13	79896596	79896596	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:79896596G>A	ENST00000438737.2	-	21	3262	c.2820_splice	c.e21-1	p.A941_splice	RBM26_ENST00000438724.1_Splice_Site_p.A917_splice|RBM26_ENST00000267229.7_Splice_Site_p.A914_splice			Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	941	RRM 2.				mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		ATGAACTGCAGCCTAAAATGA	0.303000													49	25					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74452038	74452038	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:74452038C>T	ENST00000394019.2	-	28	3572	c.3175G>A	c.(3175-3177)Gag>Aag	p.E1059K	SLC4A5_ENST00000346834.4_Missense_Mutation_p.E978K|SLC4A5_ENST00000359484.4_Missense_Mutation_p.E957K|SLC4A5_ENST00000377632.1_Missense_Mutation_p.E978K|SLC4A5_ENST00000377634.4_Missense_Mutation_p.E1075K|SLC4A5_ENST00000358683.4_Missense_Mutation_p.E957K|SLC4A5_ENST00000423644.1_3'UTR|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000357822.5_Missense_Mutation_p.E1075K|RP11-287D1.3_ENST00000451608.2_3'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	1075						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						TTTTCCTTCTCTGGGAGGATG	0.527000													38	55					0	0	1	0	0
ABCF1	23	broad.mit.edu	37	6	30557645	30557645	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:30557645G>A	ENST00000326195.8	+	22	2239	c.2127G>A	c.(2125-2127)gaG>gaA	p.E709E	ABCF1_ENST00000396515.4_Intron|ABCF1_ENST00000376545.3_Silent_p.E671E	NM_001025091.1	NP_001020262.1	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 1	709	ABC transporter 2.				inflammatory response|translational initiation	nuclear envelope|nucleoplasm|polysomal ribosome	ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(3)|skin(2)	21						CGCCCACTGAGTACCTGCAGC	0.597000													110	89					0	0	1	0	0
CBL	867	broad.mit.edu	37	11	119170443	119170443	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:119170443C>T	ENST00000264033.4	+	16	3049	c.2673C>T	c.(2671-2673)atC>atT	p.I891I		NM_005188.3	NP_005179.2	P22681	CBL_HUMAN	Cbl proto-oncogene, E3 ubiquitin protein ligase	891	Interaction with CD2AP.|UBA.				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(194)|kidney(3)|large_intestine(9)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	251		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		CCAAAAACATCCTCCGGGAAT	0.493000			"""T, Mis S, O"""	MLL	"""AML, JMML, MDS"""				Noonan syndrome;CBL gene-associated Juvenile Myelomonocytic Leukemia and Developmental Anomalies				218	310					0	0	1	0	0
DNAH17	8632	broad.mit.edu	37	17	76501379	76501379	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:76501379C>T	ENST00000389840.5	-	31	5064	c.4940G>A	c.(4939-4941)gGg>gAg	p.G1647E	DNAH17_ENST00000585328.1_Missense_Mutation_p.G1648E					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ACTCACCTGCCCCGAGAGGTC	0.597000													12	21					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135032400	135032400	+	Silent	SNP	C	C	T	rs139504552		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:135032400C>T	ENST00000304613.3	+	27	4764	c.4743C>T	c.(4741-4743)ttC>ttT	p.F1581F	KNDC1_ENST00000368572.2_Silent_p.F1583F			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	1581	Ras-GEF.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		AGAGAAACTTCGCGACAGCCA	0.567000													4	88					0	0	1	0	0
GSTA2	2939	broad.mit.edu	37	6	52615490	52615490	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:52615490T>C	ENST00000493422.1	-	7	709	c.554A>G	c.(553-555)aAa>aGa	p.K185R		NM_000846.4	NP_000837.3	P09210	GSTA2_HUMAN	glutathione S-transferase alpha 2	185	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Lung NSC(77;0.118)				Aminophenazone(DB01424)|Amsacrine(DB00276)|Busulfan(DB01008)|Chlorambucil(DB00291)|Chloroquine(DB00608)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Ethacrynic acid(DB00903)|Glutathione(DB00143)|Mechlorethamine(DB00888)|Praziquantel(DB01058)|Vitamin E(DB00163)	GATTCTGGTTTTCAGGGCCTG	0.493000													36	54					0	0	1	0	0
KIF5A	3798	broad.mit.edu	37	12	57972099	57972099	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:57972099G>A	ENST00000455537.2	+	23	2786	c.2512G>A	c.(2512-2514)Gaa>Aaa	p.E838K	KIF5A_ENST00000286452.5_Missense_Mutation_p.E749K	NM_004984.2	NP_004975.2	Q12840	KIF5A_HUMAN	kinesin family member 5A	838					blood coagulation|cell death|microtubule-based movement|synaptic transmission	cytosol|kinesin complex|membrane fraction|microtubule|perinuclear region of cytoplasm	ATP binding|microtubule motor activity			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|liver(1)|lung(32)|ovary(2)|prostate(2)|skin(2)	62						GAACAACCTGGAACAGCTTAC	0.473000													31	43					0	0	1	0	0
GSTA1	2938	broad.mit.edu	37	6	52656675	52656675	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:52656675C>T	ENST00000334575.5	-	7	805	c.650G>A	c.(649-651)aGg>aAg	p.R217K	GSTA1_ENST00000493331.1_5'UTR	NM_145740.3	NP_665683.1	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1	217					glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	12	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	GAAAATCTTCCTTGCTTCTTC	0.418000													21	67					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19751676	19751676	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:19751676G>A	ENST00000400113.3	-	4	551	c.447C>T	c.(445-447)ttC>ttT	p.F149F		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	149					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		GCAGAGATGCGAACCCAGAGC	0.567000													47	65					0	0	1	0	0
FAAH2	158584	broad.mit.edu	37	X	57515256	57515256	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:57515256C>T	ENST00000374900.4	+	11	1610	c.1490C>T	c.(1489-1491)cCt>cTt	p.P497L	FAAH2_ENST00000491179.1_3'UTR	NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	497						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						AAAGGACTCCCTTTAGGCATC	0.502000										HNSCC(52;0.14)			19	4					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126373497	126373497	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:126373497C>T	ENST00000394329.3	+	9	11339	c.11326C>T	c.(11326-11328)Ccc>Tcc	p.P3776S	FAT4_ENST00000335110.5_Missense_Mutation_p.P2074S	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3776					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GTATGTGAATCCCAGTGGCGT	0.463000													53	31					0	0	1	0	0
AP3B2	8120	broad.mit.edu	37	15	83333685	83333685	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:83333685C>T	ENST00000261722.3	-	17	2189	c.1982G>A	c.(1981-1983)tGg>tAg	p.W661*	AP3B2_ENST00000535348.1_Nonsense_Mutation_p.W629*|AP3B2_ENST00000535359.1_Nonsense_Mutation_p.W680*|RP11-752G15.3_ENST00000560650.1_RNA	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit	661	Glu/Ser-rich.				endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			GCACTTGGTCCATTCAGGTAC	0.547000													4	6					0	0	1	0	0
SPTA1	6708	broad.mit.edu	37	1	158615073	158615073	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:158615073C>T	ENST00000368148.3	-	29	4279	c.4099G>A	c.(4099-4101)Gaa>Aaa	p.E1367K	SPTA1_ENST00000368147.3_Missense_Mutation_p.E1367K	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1367					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					AGCTTTTTTTCAATTTCAGGG	0.507000													18	85					0	0	1	0	0
GALNT11	63917	broad.mit.edu	37	7	151791535	151791535	+	Missense_Mutation	SNP	A	A	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:151791535A>C	ENST00000434507.1	+	4	660	c.223A>C	c.(223-225)Aaa>Caa	p.K75Q	GALNT11_ENST00000482812.1_3'UTR|GALNT11_ENST00000415421.1_Missense_Mutation_p.K75Q|GALNT11_ENST00000320311.2_Missense_Mutation_p.K75Q|GALNT11_ENST00000452146.2_Intron|GALNT11_ENST00000422997.2_Missense_Mutation_p.K75Q|GALNT11_ENST00000430044.2_Missense_Mutation_p.K75Q			Q8NCW6	GLT11_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)	75						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(7)|prostate(5)|skin(2)	27	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.214)	OV - Ovarian serous cystadenocarcinoma(82;0.00168)	UCEC - Uterine corpus endometrioid carcinoma (81;0.177)|BRCA - Breast invasive adenocarcinoma(188;0.0932)		CAAAGCAAACAAAATTGACGA	0.463000													36	49					0	0	1	0	0
FARP2	9855	broad.mit.edu	37	2	242396268	242396268	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:242396268C>T	ENST00000264042.3	+	14	1688	c.1518C>T	c.(1516-1518)tcC>tcT	p.S506S	FARP2_ENST00000545004.1_Silent_p.S506S|FARP2_ENST00000373287.4_Silent_p.S506S	NM_014808.2	NP_055623.1	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	506	Pro-rich.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	43		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		AGGGCTCATCCCCACTCCTGA	0.637000													25	46					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167630771	167630771	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:167630771G>A	ENST00000519204.1	+	17	3263	c.3145G>A	c.(3145-3147)Gag>Aag	p.E1049K	TENM2_ENST00000545108.1_Missense_Mutation_p.E1170K|TENM2_ENST00000518659.1_Missense_Mutation_p.E1170K|TENM2_ENST00000403607.2_Missense_Mutation_p.E994K|TENM2_ENST00000520394.1_Missense_Mutation_p.E938K					teneurin transmembrane protein 2																		TCAGGGATTCGAGCTGGACCC	0.502000													31	102					0	0	1	0	0
CYP4F2	8529	broad.mit.edu	37	19	15989651	15989651	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:15989651G>A	ENST00000221700.5	-	13	1588	c.1493C>T	c.(1492-1494)cCc>cTc	p.P498L	CYP4F2_ENST00000592328.1_Missense_Mutation_p.P498L	NM_001082.3	NP_001073.3	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 2	498					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			NS(2)|breast(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46						CTTCCTGCGGGGCTCGGTGTG	0.667000													4	62					0	0	1	0	0
CRYGA	1418	broad.mit.edu	37	2	209028143	209028143	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:209028143G>A	ENST00000304502.4	-	2	56	c.37C>T	c.(37-39)Cag>Tag	p.Q13*		NM_014617.3	NP_055432.2			crystallin, gamma A											endometrium(1)|kidney(3)|large_intestine(1)|lung(7)	12				Epithelial(149;0.067)|LUSC - Lung squamous cell carcinoma(261;0.0708)|Lung(261;0.135)		CAGCGACCCTGAAAGTCTCGG	0.542000													31	78					0	0	1	0	0
TEX14	56155	broad.mit.edu	37	17	56699100	56699100	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:56699100G>A	ENST00000389934.3	-	5	582	c.465C>T	c.(463-465)atC>atT	p.I155I	TEX14_ENST00000240361.8_Silent_p.I155I|TEX14_ENST00000349033.5_Silent_p.I155I	NM_001201457.1|NM_198393.3	NP_001188386.1|NP_938207.2	Q8IWB6	TEX14_HUMAN	testis expressed 14	155						cytoplasm	ATP binding|protein kinase activity			breast(6)|endometrium(5)|kidney(3)|large_intestine(22)|liver(1)|lung(24)|ovary(4)|pancreas(1)|prostate(1)|skin(5)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	81	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGAAGCCCTGGATGATGGCCT	0.582000													25	37					0	0	1	0	0
SPEN	23013	broad.mit.edu	37	1	16256880	16256880	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:16256880C>T	ENST00000375759.3	+	11	4349	c.4145C>T	c.(4144-4146)tCt>tTt	p.S1382F		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	1382					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CCTTCTGATTCTGACGAAGAT	0.433000													5	57					0	0	1	0	0
ZNF727	442319	broad.mit.edu	37	7	63538523	63538523	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:63538523A>G	ENST00000550760.3	+	4	1275	c.1096A>G	c.(1096-1098)Aga>Gga	p.R366G		NM_001159522.1	NP_001152994.1	A8MUV8	ZN727_HUMAN	zinc finger protein 727	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(2)|skin(1)|stomach(1)|urinary_tract(1)	8						TATGGAATTGAGACCTTACAA	0.388000													4	11					0	0	1	0	0
CCDC70	83446	broad.mit.edu	37	13	52440032	52440032	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:52440032G>A	ENST00000242819.4	+	2	814	c.518G>A	c.(517-519)gGg>gAg	p.G173E		NM_031290.2	NP_112580.2	Q6NSX1	CCD70_HUMAN	coiled-coil domain containing 70	173						extracellular region|plasma membrane				breast(1)|large_intestine(4)|lung(7)|skin(2)|urinary_tract(1)	15		Breast(56;0.000207)|Lung NSC(96;0.00145)|Prostate(109;0.0107)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;2.4e-08)		CTCCTTGAGGGGGAGAAAGCC	0.547000													37	109					0	0	1	0	0
TRHR	7201	broad.mit.edu	37	8	110099808	110099808	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:110099808G>A	ENST00000518632.1	+	2	418	c.67G>A	c.(67-69)Gaa>Aaa	p.E23K	TRHR_ENST00000311762.2_Missense_Mutation_p.E23K			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	23						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			GGTGGCCTTAGAATACCAGGT	0.458000													27	33					0	0	1	0	0
GLYATL1	92292	broad.mit.edu	37	11	58722282	58722282	+	Missense_Mutation	SNP	C	C	T	rs151204927		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:58722282C>T	ENST00000300079.5	+	5	369	c.319C>T	c.(319-321)Cgt>Tgt	p.R107C	GLYATL1_ENST00000317391.4_Missense_Mutation_p.R76C|RP11-142C4.6_ENST00000533954.1_RNA	NM_001220496.1|NM_080661.3	NP_001207425.1|NP_542392.2	Q969I3	GLYL1_HUMAN	glycine-N-acyltransferase-like 1	76						mitochondrion	glycine N-acyltransferase activity			NS(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|skin(4)|urinary_tract(1)	34					Glycine(DB00145)	AAACGTATATCGTATGTTCTC	0.383000													25	42					0	0	1	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90573152	90573152	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:90573152C>T	ENST00000551025.1	+	0	3161							Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2						cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		CAACCTGTTTCCCAGGATAAT	0.368000													11	4					0	0	1	0	0
MMACHC	25974	broad.mit.edu	37	1	45973110	45973110	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:45973110C>T	ENST00000401061.4	+	2	444	c.164C>T	c.(163-165)aCg>aTg	p.T55M		NM_015506.2	NP_056321.2	Q9Y4U1	MMAC_HUMAN	methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria	55							cobalamin binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	8	Acute lymphoblastic leukemia(166;0.155)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GTACTCAGCACGCCTGCCATG	0.587000													4	74					0	0	1	0	0
ADAM29	11086	broad.mit.edu	37	4	175898711	175898711	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:175898711C>T	ENST00000359240.3	+	5	2705	c.2035C>T	c.(2035-2037)Ctg>Ttg	p.L679L	ADAM29_ENST00000514159.1_Silent_p.L679L|ADAM29_ENST00000404450.4_Silent_p.L679L|ADAM29_ENST00000445694.1_Silent_p.L679L	NM_001278125.1|NM_014269.4	NP_001265054.1|NP_055084.3	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29	679					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(25)|ovary(3)|pancreas(1)|prostate(7)|skin(24)|urinary_tract(2)	93		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		GTTCTGTTATCTGTGTATATT	0.358000													6	28					0	0	1	0	0
PXDNL	137902	broad.mit.edu	37	8	52287214	52287214	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:52287214C>T	ENST00000356297.4	-	18	3735	c.3635G>A	c.(3634-3636)gGa>gAa	p.G1212E	PXDNL_ENST00000543296.1_Missense_Mutation_p.G1212E	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1212					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				AAGTGTTGGTCCCACTCTTGT	0.458000													6	43					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96602692	96602692	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:96602692G>A	ENST00000371321.3	+	7	1142	c.1060G>A	c.(1060-1062)Gag>Aag	p.E354K	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	354					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	TGTGGTGCACGAGGTCCAGAG	0.532000													77	29					0	0	1	0	0
LACRT	90070	broad.mit.edu	37	12	55025539	55025539	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:55025539C>T	ENST00000257867.4	-	4	391	c.338G>A	c.(337-339)gGa>gAa	p.G113E	LACRT_ENST00000547511.1_Missense_Mutation_p.G102E	NM_033277.1	NP_150593.1	Q9GZZ8	LACRT_HUMAN	lacritin	113					calcineurin-NFAT signaling pathway|positive regulation of epithelial cell proliferation|positive regulation of NFAT protein import into nucleus|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of secretion|protein localization in Golgi apparatus|tear secretion	extracellular region|stored secretory granule	collagen binding|fibronectin binding|glycoprotein binding|growth factor activity|laminin-1 binding|protein N-terminus binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(4)|stomach(1)	10						GAATTGTTTTCCACCTGGCAC	0.473000													13	68					0	0	1	0	0
SPEG	10290	broad.mit.edu	37	2	220355280	220355280	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:220355280C>T	ENST00000312358.7	+	37	9203	c.9071C>T	c.(9070-9072)tCc>tTc	p.S3024F	AC053503.11_ENST00000429882.1_RNA|SPEG_ENST00000485813.1_3'UTR	NM_005876.4	NP_005867.3	Q15772	SPEG_HUMAN	SPEG complex locus	3024	Protein kinase 2.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(3)|endometrium(10)|kidney(2)|large_intestine(9)|lung(42)|ovary(5)|pancreas(1)|prostate(8)|skin(1)|stomach(9)|upper_aerodigestive_tract(4)|urinary_tract(4)	100		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		CGGATCATGTCCCTGCACGAG	0.632000													23	29					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170955831	170955831	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:170955831C>T	ENST00000367759.4	+	10	1013	c.859C>T	c.(859-861)Cat>Tat	p.H287Y	MROH9_ENST00000367758.3_Missense_Mutation_p.H287Y	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		TCTGGAATTTCATGCCGAGAA	0.428000													14	82					0	0	1	0	0
MYH11	4629	broad.mit.edu	37	16	15815413	15815413	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:15815413C>T	ENST00000338282.6	-	32	4550	c.4444G>A	c.(4444-4446)Gaa>Aaa	p.E1482K	NDE1_ENST00000396355.1_Intron|MYH11_ENST00000576790.1_Missense_Mutation_p.E1482K|NDE1_ENST00000342673.5_Intron|NDE1_ENST00000396354.1_Intron|MYH11_ENST00000452625.2_Missense_Mutation_p.E1489K|MYH11_ENST00000396324.3_Missense_Mutation_p.E1489K|MYH11_ENST00000300036.5_Missense_Mutation_p.E1482K	NM_022844.2	NP_074035.1	P35749	MYH11_HUMAN	myosin, heavy chain 11, smooth muscle	1482					axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(34)|liver(1)|lung(37)|ovary(9)|pancreas(1)|prostate(7)|skin(7)|upper_aerodigestive_tract(1)	123						GCCTTGGTTTCCTTCTCCCTG	0.532000			T	CBFB	AML								43	56					0	0	1	0	0
DNAH8	1769	broad.mit.edu	37	6	38874181	38874181	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:38874181G>A	ENST00000359357.3	+	61	8949	c.8695G>A	c.(8695-8697)Gag>Aag	p.E2899K	DNAH8_ENST00000449981.2_Missense_Mutation_p.E3116K|DNAH8_ENST00000441566.1_Missense_Mutation_p.E2863K					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						ATCTTCAGGGGAGGTAAGTCT	0.338000													7	17					0	0	1	0	0
CTRC	11330	broad.mit.edu	37	1	15772136	15772136	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:15772136C>T	ENST00000375949.4	+	7	710	c.684C>T	c.(682-684)tcC>tcT	p.S228S	CTRC_ENST00000483406.1_3'UTR|CTRC_ENST00000375943.2_3'UTR	NM_007272.2	NP_009203.2	Q99895	CTRC_HUMAN	chymotrypsin C (caldecrin)	228	Peptidase S1.				proteolysis		serine-type endopeptidase activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)	13		Breast(348;0.000207)|all_lung(284;0.00021)|Colorectal(325;0.000257)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)|Hepatocellular(190;0.0634)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		AGAACGGTTCCTGGGAGGTGT	0.647000													93	49					0	0	1	0	0
SNX19	399979	broad.mit.edu	37	11	130784874	130784874	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:130784874C>T	ENST00000265909.4	-	1	1530	c.961G>A	c.(961-963)Ggt>Agt	p.G321S	SNX19_ENST00000539184.1_Intron|SNX19_ENST00000530356.1_Intron|SNX19_ENST00000528555.1_Intron|SNX19_ENST00000533318.1_Intron|SNX19_ENST00000533214.1_Missense_Mutation_p.G321S	NM_014758.2	NP_055573.2	Q92543	SNX19_HUMAN	sorting nexin 19	321					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(8)|ovary(3)|prostate(1)|skin(6)|urinary_tract(1)	35	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		CCTGCAGAACCCTCTGGCTCA	0.522000													35	52					0	0	1	0	0
ITGAD	3681	broad.mit.edu	37	16	31422716	31422716	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:31422716G>A	ENST00000389202.2	+	14	1634	c.1585G>A	c.(1585-1587)Gat>Aat	p.D529N		NM_005353.2	NP_005344.2	Q13349	ITAD_HUMAN	integrin, alpha D	529					cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						AGTGTTGGGGGATGTGAATGA	0.622000													84	142					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1265952	1265952	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:1265952G>A	ENST00000447027.1	+	31	7909	c.7851G>A	c.(7849-7851)acG>acA	p.T2617T	MUC5B_ENST00000529681.1_Silent_p.T2614T|RP11-532E4.2_ENST00000532061.2_RNA			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2614	11 X approximate tandem repeats, Ser/Thr- rich.|7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCACAACCACGGGCTTCACAG	0.647000													82	120					0	0	1	0	0
CLEC16A	23274	broad.mit.edu	37	16	11114054	11114054	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:11114054C>T	ENST00000409790.1	+	12	1538	c.1308C>T	c.(1306-1308)atC>atT	p.I436I	CLEC16A_ENST00000409552.3_Silent_p.I418I	NM_015226.2	NP_056041.1	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	436								p.0?(1)		breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						TTCCAGAGATCGAGATGGTGA	0.517000													23	28					0	0	1	0	0
ITLN1	55600	broad.mit.edu	37	1	160850433	160850433	+	Silent	SNP	G	G	A	rs140203242		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:160850433G>A	ENST00000326245.3	-	6	745	c.630C>T	c.(628-630)gtC>gtT	p.V210V	ITLN1_ENST00000487531.1_5'UTR	NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)	210	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CAAAATCATAGACCACAGGGA	0.443000													89	156					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179466495	179466495	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179466495G>A	ENST00000589042.1	-	286	55546	c.55322C>T	c.(55321-55323)tCc>tTc	p.S18441F	TTN_ENST00000342992.6_Missense_Mutation_p.S15873F|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.S16800F|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.S9376F|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.S9568F|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.S9501F|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	16800	Ig-like 106.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AATTACTGAGGAGTTTTCAGC	0.343000													25	43					0	0	1	0	0
GUCY2F	2986	broad.mit.edu	37	X	108636170	108636170	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:108636170C>T	ENST00000218006.2	-	13	2830	c.2539G>A	c.(2539-2541)Gaa>Aaa	p.E847K		NM_001522.2	NP_001513.2	P51841	GUC2F_HUMAN	guanylate cyclase 2F, retinal	847					intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			breast(3)|central_nervous_system(2)|endometrium(5)|kidney(6)|large_intestine(14)|lung(33)|prostate(3)|skin(1)	67						TTTTCAATTTCCAGCTCTTCA	0.403000													54	10					0	0	1	0	0
TAS2R9	50835	broad.mit.edu	37	12	10962343	10962343	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:10962343A>T	ENST00000240691.2	-	1	424	c.332T>A	c.(331-333)aTa>aAa	p.I111K		NM_023917.2	NP_076406.1	Q9NYW1	TA2R9_HUMAN	taste receptor, type 2, member 9	111					sensory perception of taste	integral to membrane	taste receptor activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						TATATTGGCTATCTTGAGTAA	0.378000													12	27					0	0	1	0	0
ATP8B4	79895	broad.mit.edu	37	15	50336869	50336869	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:50336869G>A	ENST00000284509.6	-	5	363	c.222C>T	c.(220-222)tcC>tcT	p.S74S	ATP8B4_ENST00000559829.1_Silent_p.S74S|ATP8B4_ENST00000558959.1_5'UTR	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	74					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		ACCAGGTCAAGGAGGAAATTT	0.363000													15	21					0	0	1	0	0
SLC11A1	6556	broad.mit.edu	37	2	219254649	219254649	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:219254649C>T	ENST00000233202.6	+	9	1192	c.852C>T	c.(850-852)ttC>ttT	p.F284F	SLC11A1_ENST00000539932.1_Silent_p.F166F	NM_000578.3	NP_000569.3	P49279	NRAM1_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1	284					activation of protein kinase activity|antigen processing and presentation of peptide antigen|cadmium ion transmembrane transport|cellular cadmium ion homeostasis|cellular iron ion homeostasis|defense response to Gram-negative bacterium|defense response to protozoan|divalent metal ion export|inflammatory response|interleukin-2 production|interleukin-3 production|iron ion transport|L-arginine import|macrophage activation|MHC class II biosynthetic process|mRNA stabilization|multicellular organismal iron ion homeostasis|negative regulation of cytokine production|nitrite transport|phagocytosis|positive regulation of dendritic cell antigen processing and presentation|positive regulation of interferon-gamma production|positive regulation of phagocytosis|positive regulation of T-helper 1 type immune response|positive regulation of transcription from RNA polymerase II promoter|respiratory burst|response to interferon-gamma|response to lipopolysaccharide|T cell cytokine production|T cell proliferation involved in immune response|vacuolar acidification|wound healing	integral to plasma membrane|late endosome membrane|lysosome|phagocytic vesicle membrane|tertiary granule membrane	manganese ion transmembrane transporter activity|metal ion:hydrogen antiporter activity|protein homodimerization activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	19		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000195)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		ACATGTACTTCCTGATTGAGG	0.537000													20	29					0	0	1	0	0
SLC45A4	57210	broad.mit.edu	37	8	142221623	142221623	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:142221623G>A	ENST00000024061.3	-	8	2622	c.2315C>T	c.(2314-2316)cCa>cTa	p.P772L	SLC45A4_ENST00000433583.2_3'UTR|SLC45A4_ENST00000519067.1_3'UTR|SLC45A4_ENST00000517878.1_3'UTR	NM_001080431.1	NP_001073900.1	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	0					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GGGCTGCCCTGGGCACAATGT	0.507000													67	136					0	0	1	0	0
SYNJ2	8871	broad.mit.edu	37	6	158504540	158504540	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:158504540G>A	ENST00000355585.4	+	21	3020	c.2945G>A	c.(2944-2946)cGa>cAa	p.R982Q	SYNJ2_ENST00000367121.3_Missense_Mutation_p.R982Q|SYNJ2_ENST00000367112.1_Missense_Mutation_p.R67Q|SYNJ2_ENST00000367122.2_Missense_Mutation_p.R982Q	NM_001178088.1|NM_003898.3	NP_001171559.1|NP_003889.1	O15056	SYNJ2_HUMAN	synaptojanin 2	982							nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			biliary_tract(1)|endometrium(9)|kidney(3)|large_intestine(11)|lung(14)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(65;4.42e-18)|BRCA - Breast invasive adenocarcinoma(81;4.23e-05)		ATTCGGAAACGAGACAGCATG	0.532000													32	39					0	0	1	0	0
DUSP8	1850	broad.mit.edu	37	11	1586955	1586955	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:1586955G>A	ENST00000397374.3	-	2	229	c.102C>T	c.(100-102)tcC>tcT	p.S34S	DUSP8_ENST00000331588.4_Silent_p.S34S	NM_004420.2	NP_004411.2	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	34	Rhodanese.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity			endometrium(1)|lung(2)|prostate(1)|urinary_tract(1)	5		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		ACTCCACGAAGGAGCGGCTGT	0.662000													71	122					0	0	1	0	0
SIK1	150094	broad.mit.edu	37	21	44836750	44836750	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:44836750G>A	ENST00000270162.6	-	14	2356	c.2224C>T	c.(2224-2226)Ccc>Tcc	p.P742S		NM_173354.3	NP_775490.2	P57059	SIK1_HUMAN	salt-inducible kinase 1	742					anoikis|cell cycle|cell differentiation|intracellular protein kinase cascade|multicellular organismal development|regulation of cell differentiation|regulation of mitotic cell cycle	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(2)|testis(2)|urinary_tract(1)	21						GGCACAGCGGGGAGGGCGGTG	0.731000													7	13					0	0	1	0	0
IGHV1OR16-4	28312	broad.mit.edu	37	16	33013856	33013856	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:33013856C>T	ENST00000567619.1	-	0	499																											GTGAAGGTCTCCTGCCAGGCT	0.567000													26	67					0	0	1	0	0
C1QTNF7	114905	broad.mit.edu	37	4	15444230	15444230	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:15444230G>A	ENST00000295297.4	+	3	957	c.698G>A	c.(697-699)gGa>gAa	p.G233E	C1QTNF7_ENST00000429690.1_Missense_Mutation_p.G226E|C1QTNF7_ENST00000444304.2_Missense_Mutation_p.G226E	NM_001135170.1	NP_001128642.1	Q9BXJ2	C1QT7_HUMAN	C1q and tumor necrosis factor related protein 7	226	C1q.					collagen				endometrium(5)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|stomach(1)	16						GCCAACACAGGAAACCATGAT	0.458000													93	48					0	0	1	0	0
PASK	23178	broad.mit.edu	37	2	242080067	242080067	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:242080067C>T	ENST00000403638.3	-	3	389	c.298G>A	c.(298-300)Gaa>Aaa	p.E100K	PASK_ENST00000539818.1_Intron|PASK_ENST00000358649.4_Missense_Mutation_p.E100K|PASK_ENST00000544142.1_Intron|PASK_ENST00000405260.1_Missense_Mutation_p.E100K|PASK_ENST00000234040.4_Missense_Mutation_p.E100K	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	100					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity	p.E100K(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		CCCCGCGGTTCGGACGGGTCC	0.597000													28	37					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41711115	41711115	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:41711115C>T	ENST00000400454.1	-	7	1915	c.1438G>A	c.(1438-1440)Gga>Aga	p.G480R		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	480	Ig-like C2-type 5.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				CGGTAGACTCCCCCGTCCCGG	0.562000													14	42					0	0	1	0	0
DNAH10	196385	broad.mit.edu	37	12	124323032	124323032	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:124323032G>A	ENST00000409039.3	+	28	4603	c.4578G>A	c.(4576-4578)gtG>gtA	p.V1526V		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1526	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		AAGACCCCGTGATCAAGAGGT	0.547000													7	21					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181706660	181706660	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:181706660G>A	ENST00000526775.1	+	22	3530		c.e22-1		CACNA1E_ENST00000357570.5_Splice_Site|CACNA1E_ENST00000367573.2_Splice_Site|CACNA1E_ENST00000360108.3_Splice_Site|CACNA1E_ENST00000367567.4_Splice_Site|CACNA1E_ENST00000358338.5_Splice_Site|CACNA1E_ENST00000367570.1_Splice_Site	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit						energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						ACTGCCCGCAGGATCCGGAGG	0.622000													4	75					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164716450	164716450	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:164716450T>C	ENST00000264382.3	-	38	4480	c.4418A>G	c.(4417-4419)aAg>aGg	p.K1473R		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	1473	Sucrase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TCCAGTTGTCTTCTGCAATGC	0.373000										HNSCC(35;0.089)			13	25					0	0	1	0	0
ARID5B	84159	broad.mit.edu	37	10	63852508	63852508	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:63852508C>T	ENST00000279873.7	+	10	3696	c.3286C>T	c.(3286-3288)Ccg>Tcg	p.P1096S	ARID5B_ENST00000309334.5_Missense_Mutation_p.P853S	NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	1096					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					CTCCAGGCTCCCGGCTGGGTA	0.567000													6	69					0	0	1	0	0
EGFLAM	133584	broad.mit.edu	37	5	38425169	38425169	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:38425169G>A	ENST00000322350.5	+	13	2131	c.1785G>A	c.(1783-1785)ggG>ggA	p.G595G	EGFLAM_ENST00000354891.3_Silent_p.G595G|EGFLAM_ENST00000397202.2_5'UTR|EGFLAM_ENST00000336740.6_Silent_p.G361G|EGFLAM-AS1_ENST00000508986.1_RNA	NM_152403.3	NP_689616.2	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G domains	595	EGF-like 2.					cell junction|proteinaceous extracellular matrix|synapse				NS(1)|breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(43)|ovary(1)|pancreas(3)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	85	all_lung(31;0.000385)					GTCCCCTTGGGTTTAAAGGTC	0.463000													56	178					0	0	1	0	0
DMBT1	1755	broad.mit.edu	37	10	124336085	124336085	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:124336085C>T	ENST00000338354.3	+	7	560	c.454C>T	c.(454-456)Cca>Tca	p.P152S	DMBT1_ENST00000344338.3_Missense_Mutation_p.P152S|DMBT1_ENST00000368955.3_Missense_Mutation_p.P152S|DMBT1_ENST00000359586.6_Missense_Mutation_p.P152S|DMBT1_ENST00000330163.4_Missense_Mutation_p.P152S|DMBT1_ENST00000368909.3_Missense_Mutation_p.P152S|DMBT1_ENST00000368956.2_Missense_Mutation_p.P152S			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	152	SRCR 1.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CATGTCAGCTCCAGGAAATGC	0.602000													128	52					0	0	1	0	0
NLRP9	338321	broad.mit.edu	37	19	56220346	56220346	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:56220346G>A	ENST00000332836.2	-	9	2935	c.2908C>T	c.(2908-2910)Ccc>Tcc	p.P970S	CTD-2611O12.8_ENST00000596293.1_RNA	NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	970						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		GTCAGATGGGGAATTTTTTCT	0.413000													11	20					0	0	1	0	0
DSEL	92126	broad.mit.edu	37	18	65179567	65179567	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:65179567C>A	ENST00000310045.7	-	2	3782	c.2309G>T	c.(2308-2310)aGa>aTa	p.R770I	CTD-2541J13.2_ENST00000583493.1_RNA	NM_032160.2	NP_115536.1	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	760						integral to membrane	isomerase activity|sulfotransferase activity			NS(3)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(25)|lung(23)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	74		Esophageal squamous(42;0.129)				CCTATCATGTCTTACAGGCTT	0.378000													24	32					6.32553e-13	6.39267e-13	1	1	0
GALNT8	26290	broad.mit.edu	37	12	4872537	4872537	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:4872537C>T	ENST00000252318.2	+	8	1815	c.1478C>T	c.(1477-1479)aCc>aTc	p.T493I		NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	493						Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						CCACTCCACACCATCGTGGGC	0.413000													20	40					0	0	1	0	0
MYH14	79784	broad.mit.edu	37	19	50784856	50784856	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:50784856C>T	ENST00000440075.2	+	33	4343	c.4296C>T	c.(4294-4296)tcC>tcT	p.S1432S	MYH14_ENST00000596571.1_Silent_p.S1391S|MYH14_ENST00000425460.1_Silent_p.S1399S|MYH14_ENST00000376970.2_Silent_p.S1424S|MYH14_ENST00000262269.8_Silent_p.S1432S|MYH14_ENST00000601313.1_Silent_p.S1432S|MYH14_ENST00000598205.1_Silent_p.S1399S			Q7Z406	MYH14_HUMAN	myosin, heavy chain 14, non-muscle	1391					axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(10)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	46		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		CTCAGCTTTCCGAGTGGCGGC	0.682000													6	21					0	0	1	0	0
WDFY3	23001	broad.mit.edu	37	4	85599427	85599427	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:85599427G>A	ENST00000322366.6	-	65	10509	c.10102C>T	c.(10102-10104)Cga>Tga	p.R3368*	WDFY3_ENST00000295888.4_Nonsense_Mutation_p.R3385*			Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3	3385						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CGTTCCCATCGGTACCCTGGA	0.502000													31	40					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12853479	12853479	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:12853479C>T	ENST00000332296.7	+	2	206	c.103C>T	c.(103-105)Ctc>Ttc	p.L35F		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	35										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GCCCAGGGTGCTCTATCTCCC	0.617000													34	155					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53084897	53084897	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:53084897C>T	ENST00000276480.7	-	10	1207	c.524G>A	c.(523-525)gGa>gAa	p.G175E		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	175						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CTTGTCTCTTCCATCATCAGA	0.433000													21	31					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179613170	179613170	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179613170C>T	ENST00000360870.5	-	46	14179	c.13957G>A	c.(13957-13959)Gaa>Aaa	p.E4653K	TTN_ENST00000342992.6_Intron|TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000342175.6_Intron|TTN_ENST00000359218.5_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	767	Ig-like 26.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTAACGTTTCAGGGCTAGGA	0.368000													42	59					0	0	1	0	0
POU6F2	11281	broad.mit.edu	37	7	39243911	39243911	+	Missense_Mutation	SNP	C	C	T	rs148094915		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:39243911C>T	ENST00000518318.2	+	3	310	c.268C>T	c.(268-270)Cca>Tca	p.P90S	POU6F2_ENST00000559001.1_Missense_Mutation_p.P82S|POU6F2_ENST00000403058.1_Missense_Mutation_p.P90S|POU6F2_ENST00000517348.1_3'UTR			P78424	PO6F2_HUMAN	POU class 6 homeobox 2	90					central nervous system development|ganglion mother cell fate determination|transcription from RNA polymerase II promoter|visual perception		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(16)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	42						CCCCCCATTTCCAGTTGGGCC	0.453000													12	14					0	0	1	0	0
RBP2	5948	broad.mit.edu	37	3	139181066	139181066	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:139181066C>T	ENST00000232217.2	-	2	196	c.140G>A	c.(139-141)gGt>gAt	p.G47D	RP11-319G6.1_ENST00000515247.1_RNA	NM_004164.2	NP_004155.2	P50120	RET2_HUMAN	retinol binding protein 2, cellular	47					epidermis development|retinoid metabolic process|steroid metabolic process|vitamin A metabolic process	cytosol	retinal binding|retinol binding|transporter activity			breast(1)|large_intestine(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12					Vitamin A(DB00162)	GAAGTTATCACCATCTTGATC	0.428000													32	40					0	0	1	0	0
GTF2I	2969	broad.mit.edu	37	7	74159269	74159269	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:74159269C>T	ENST00000324896.4	+	21	2312	c.1923C>T	c.(1921-1923)ttC>ttT	p.F641F	GTF2I_ENST00000353920.4_Silent_p.F621F|GTF2I_ENST00000346152.4_Silent_p.F620F|GTF2I_ENST00000438130.2_3'UTR|GTF2I_ENST00000416070.1_Silent_p.F600F	NM_032999.2	NP_127492.1	P78347	GTF2I_HUMAN	general transcription factor IIi	641					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	19						AAATCAAGTTCGTTGTTAAAA	0.413000													18	38					0	0	1	0	0
SNAP91	9892	broad.mit.edu	37	6	84302256	84302256	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:84302256C>T	ENST00000428679.2	-	21	2441	c.1846_splice	c.e21-1	p.V616_splice	SNAP91_ENST00000521743.1_Splice_Site_p.V616_splice|SNAP91_ENST00000521485.1_Splice_Site_p.V616_splice|SNAP91_ENST00000369694.2_Splice_Site_p.V616_splice|SNAP91_ENST00000195649.6_Splice_Site_p.V616_splice|SNAP91_ENST00000437520.1_Intron|SNAP91_ENST00000520213.1_Intron|SNAP91_ENST00000439399.2_Splice_Site_p.V616_splice|SNAP91_ENST00000520302.1_Intron			O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa	616					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(22)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		CAAATGCATCCACTGCAGTGA	0.493000													8	15					0	0	1	0	0
ZNF608	57507	broad.mit.edu	37	5	123982628	123982628	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:123982628G>A	ENST00000306315.5	-	4	3884	c.3449C>T	c.(3448-3450)tCg>tTg	p.S1150L	ZNF608_ENST00000504926.1_Missense_Mutation_p.S723L	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	1150						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GATTGTGGCCGATGGCATATT	0.468000													30	56					0	0	1	0	0
SLC45A4	57210	broad.mit.edu	37	8	142228572	142228572	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:142228572G>A	ENST00000519067.1	-	4	1317	c.1014C>T	c.(1012-1014)tcC>tcT	p.S338S	SLC45A4_ENST00000433583.2_Silent_p.S331S|SLC45A4_ENST00000024061.3_Silent_p.S338S|SLC45A4_ENST00000517878.1_Silent_p.S389S			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	389					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CTTTTGTGGGGGAGCCACTTC	0.642000													27	59					0	0	1	0	0
LST3	0	broad.mit.edu	37	12	21196486	21196486	+	Nonsense_Mutation	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:21196486A>T	ENST00000381541.3	+	7	1011	c.946A>T	c.(946-948)Aaa>Taa	p.K316*	SLCO1B3_ENST00000553473.1_Intron|SLCO1B7_ENST00000421593.2_Nonsense_Mutation_p.K269*|LST3_ENST00000540229.1_Intron|SLCO1B7_ENST00000554957.1_Nonsense_Mutation_p.K316*																							CAACCGAAGAAAATATATTAC	0.299000													8	5					0	0	1	0	0
PLCB1	23236	broad.mit.edu	37	20	8639258	8639258	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:8639258C>T	ENST00000378641.3	+	9	1244	c.769C>T	c.(769-771)Cgg>Tgg	p.R257W	PLCB1_ENST00000378637.2_Missense_Mutation_p.R257W|PLCB1_ENST00000338037.6_Missense_Mutation_p.R257W	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	257					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						GCGAGATCCTCGGCTTAATGA	0.383000													16	56					0	0	1	0	0
GNG4	2786	broad.mit.edu	37	1	235747047	235747047	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:235747047C>T	ENST00000391854.2	-	3	545	c.92G>A	c.(91-93)aGg>aAg	p.R31K	GNG4_ENST00000450593.1_Missense_Mutation_p.R31K|GNG4_ENST00000366597.1_Missense_Mutation_p.R31K|GNG4_ENST00000366598.4_Missense_Mutation_p.R31K|GNG4_ENST00000484517.1_5'UTR	NM_001098722.1|NM_004485.3	NP_001092192.1|NP_004476.1	P50150	GBG4_HUMAN	guanine nucleotide binding protein (G protein), gamma 4	31					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|negative regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity			NS(1)|endometrium(2)|large_intestine(1)|lung(3)|prostate(1)	8	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00168)|Prostate(94;0.0776)|Acute lymphoblastic leukemia(190;0.23)	OV - Ovarian serous cystadenocarcinoma(106;0.000882)			TACCTTGACCCTGTCCATACA	0.517000													98	41					0	0	1	0	0
EXTL2	2135	broad.mit.edu	37	1	101339918	101339918	+	Silent	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:101339918A>G	ENST00000370114.3	-	5	2009	c.573T>C	c.(571-573)agT>agC	p.S191S	EXTL2_ENST00000370113.3_Silent_p.S191S|EXTL2_ENST00000535414.1_Silent_p.S178S	NM_001033025.2|NM_001261440.1	NP_001028197.1|NP_001248369.1	Q9UBQ6	EXTL2_HUMAN	exostosin-like glycosyltransferase 2	191					N-acetylglucosamine metabolic process|UDP-N-acetylgalactosamine metabolic process	extracellular region|integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,4-N-acetylgalactosaminyltransferase activity|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(4)|skin(1)|urinary_tract(1)	14		all_epithelial(167;2.48e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0425)|all cancers(265;0.0628)|COAD - Colon adenocarcinoma(174;0.148)|Colorectal(144;0.167)|Lung(183;0.195)		AACTTCCATAACTGTAGATAC	0.383000													33	16					0	0	1	0	0
OR52A1	23538	broad.mit.edu	37	11	5172775	5172775	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:5172775G>A	ENST00000380367.1	-	2	1242	c.825C>T	c.(823-825)atC>atT	p.I275I	OR52A1_ENST00000328942.1_Silent_p.I275I			Q9UKL2	O52A1_HUMAN	olfactory receptor, family 52, subfamily A, member 1	275					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			breast(2)|endometrium(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	19		Medulloblastoma(188;0.00106)|Breast(177;0.0155)|all_neural(188;0.0189)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAGAATATGGATATAAGGGG	0.433000													41	59					0	0	1	0	0
P2RY10	27334	broad.mit.edu	37	X	78216755	78216755	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:78216755C>T	ENST00000171757.2	+	4	1018	c.738C>T	c.(736-738)ttC>ttT	p.F246F	P2RY10_ENST00000544091.1_Silent_p.F246F	NM_014499.2	NP_055314.1	O00398	P2Y10_HUMAN	purinergic receptor P2Y, G-protein coupled, 10	246						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(9)|lung(22)|ovary(3)|skin(2)	42						GGATGGTGTTCATGTGTGCTG	0.443000													28	6					0	0	1	0	0
CYP4F3	4051	broad.mit.edu	37	19	15770125	15770125	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:15770125C>T	ENST00000221307.7	+	13	1541	c.1493C>T	c.(1492-1494)cCc>cTc	p.P498L	CYP4F3_ENST00000586182.1_Missense_Mutation_p.P498L|CYP4F3_ENST00000591058.1_Missense_Mutation_p.P498L|CYP4F3_ENST00000585846.1_Missense_Mutation_p.P498L	NM_000896.2	NP_000887.2	Q08477	CP4F3_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 3	498					leukotriene metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding			endometrium(3)|large_intestine(4)|lung(21)|ovary(3)|prostate(2)|stomach(1)	34						CACACCGAGCCCCGCAGGAAG	0.672000													11	19					0	0	1	0	0
KRT5	3852	broad.mit.edu	37	12	52908853	52908853	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:52908853C>T	ENST00000252242.4	-	9	2036	c.1646G>A	c.(1645-1647)gGg>gAg	p.G549E		NM_000424.3	NP_000415.2	P13647	K2C5_HUMAN	keratin 5	549	Ser-rich.|Tail.				epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		GCCAGAGCCCCCCACACTGAG	0.657000													16	35					0	0	1	0	0
CA10	56934	broad.mit.edu	37	17	49710905	49710905	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:49710905G>A	ENST00000451037.2	-	8	1836	c.896C>T	c.(895-897)aCc>aTc	p.T299I	CA10_ENST00000442502.2_Missense_Mutation_p.T299I|CA10_ENST00000340813.6_Missense_Mutation_p.T305I|CA10_ENST00000570565.1_Missense_Mutation_p.T224I|CA10_ENST00000285273.4_Missense_Mutation_p.T299I	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	299					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			GTTGATATTGGTGCGGATGCA	0.527000													37	41					0	0	1	0	0
FGF18	8817	broad.mit.edu	37	5	170883792	170883792	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:170883792C>T	ENST00000274625.5	+	5	1151	c.607C>T	c.(607-609)Ccc>Tcc	p.P203S		NM_003862.2	NP_003853.1	O76093	FGF18_HUMAN	fibroblast growth factor 18	203					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell proliferation	extracellular space|nucleolus	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding			endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	9	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TCGGATCCGGCCCACACACCC	0.602000													47	42					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129371135	129371135	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:129371135G>A	ENST00000421865.2	+	2	234	c.185G>A	c.(184-186)gGa>gAa	p.G62E		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	62	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GGAGAAAAAGGACCTGAAATG	0.453000													16	49					0	0	1	0	0
RPTN	126638	broad.mit.edu	37	1	152127867	152127867	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:152127867G>A	ENST00000316073.3	-	3	1772	c.1708C>T	c.(1708-1710)Cat>Tat	p.H570Y		NM_001122965.1	NP_001116437.1	Q6XPR3	RPTN_HUMAN	repetin	570	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding			breast(2)|central_nervous_system(1)|endometrium(14)|kidney(2)|large_intestine(1)|lung(32)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	59						TGACCATAATGATAGCTCTGG	0.488000													500	238					0	0	1	0	0
LINGO4	339398	broad.mit.edu	37	1	151775058	151775058	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:151775058G>A	ENST00000368820.3	-	2	1060	c.123C>T	c.(121-123)ccC>ccT	p.P41P		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	41	LRRNT.					integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			GCACAGCCTGGGGCTGGGAGG	0.667000													15	6					0	0	1	0	0
ENPEP	2028	broad.mit.edu	37	4	111464204	111464204	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:111464204G>A	ENST00000265162.5	+	13	2320	c.1978G>A	c.(1978-1980)Gat>Aat	p.D660N		NM_001977.3	NP_001968.3	Q07075	AMPE_HUMAN	glutamyl aminopeptidase (aminopeptidase A)	660					cell migration|cell proliferation|cell-cell signaling|proteolysis	integral to plasma membrane	aminopeptidase activity|metalloexopeptidase activity|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(1)	54		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.0031)	L-Glutamic Acid(DB00142)	AAGTCTTATTGATGATGCTTT	0.318000													53	27					0	0	1	0	0
CDK8	1024	broad.mit.edu	37	13	26927934	26927934	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:26927934C>T	ENST00000381527.3	+	4	876	c.373C>T	c.(373-375)Cgg>Tgg	p.R125W	CDK8_ENST00000536792.1_Missense_Mutation_p.R125W	NM_001260.1	NP_001251.1	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	125	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	25	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		TCAGTTACCTCGGGGAATGGT	0.373000													15	9					0	0	1	0	0
DIP2A	23181	broad.mit.edu	37	21	47971644	47971644	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:47971644C>T	ENST00000318711.7	+	24	3123	c.2940C>T	c.(2938-2940)gaC>gaT	p.D980D	DIP2A_ENST00000427143.2_Silent_p.D915D|DIP2A_ENST00000417564.2_Silent_p.D979D|DIP2A_ENST00000400274.1_Silent_p.D975D	NM_001146116.1|NM_015151.3	NP_001139588.1|NP_055966.2	Q14689	DIP2A_HUMAN	DIP2 disco-interacting protein 2 homolog A (Drosophila)	979					multicellular organismal development	nucleus	catalytic activity|transcription factor binding			cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(22)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Breast(49;0.0933)			Epithelial(3;3.12e-06)|OV - Ovarian serous cystadenocarcinoma(3;5.68e-06)|all cancers(3;4.08e-05)|Colorectal(79;0.0129)|COAD - Colon adenocarcinoma(84;0.0824)		AGGACAGCGACCAGGCACGGA	0.637000													7	18					0	0	1	0	0
CCDC150	284992	broad.mit.edu	37	2	197586282	197586282	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:197586282G>A	ENST00000389175.4	+	21	2431	c.2296G>A	c.(2296-2298)Gaa>Aaa	p.E766K	CCDC150_ENST00000272831.7_Missense_Mutation_p.E413K|CCDC150_ENST00000409270.1_Missense_Mutation_p.E253K|CCDC150_ENST00000487663.1_3'UTR	NM_001080539.1	NP_001074008.1	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150	766										breast(3)|endometrium(6)|kidney(1)|large_intestine(6)|lung(14)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	33						TGTAGCTAGAGAAGACAACAG	0.388000													9	8					0	0	1	0	0
IKZF4	64375	broad.mit.edu	37	12	56426979	56426979	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:56426979G>A	ENST00000262032.5	+	11	1238	c.871G>A	c.(871-873)Gaa>Aaa	p.E291K	IKZF4_ENST00000431367.2_Missense_Mutation_p.E189K|IKZF4_ENST00000547791.1_Missense_Mutation_p.E246K|RP11-603J24.4_ENST00000551846.1_RNA|IKZF4_ENST00000547167.1_Missense_Mutation_p.E291K			Q9H2S9	IKZF4_HUMAN	IKAROS family zinc finger 4 (Eos)	291					negative regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|lung(3)|ovary(1)|prostate(1)	8			UCEC - Uterine corpus endometrioid carcinoma (6;0.025)|OV - Ovarian serous cystadenocarcinoma(18;0.123)			ACTAGGTGACGAAATACGTGA	0.542000													11	40					0	0	1	0	0
SIGLECL1	284369	broad.mit.edu	37	19	51770777	51770777	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:51770777G>A	ENST00000316401.7	+	5	942	c.561G>A	c.(559-561)cgG>cgA	p.R187R	SIGLECL1_ENST00000597824.1_Silent_p.R93R|SIGLECL1_ENST00000593968.1_3'UTR|CTD-3187F8.2_ENST00000597569.1_RNA	NM_173635.1	NP_775906.1			SIGLEC family like 1																		CTGAGAGCCGGATATTGGTAT	0.438000													42	44					0	0	1	0	0
TMPRSS7	344805	broad.mit.edu	37	3	111799810	111799810	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:111799810G>A	ENST00000452346.2	+	18	2414	c.2411G>A	c.(2410-2412)tGg>tAg	p.W804*	TMPRSS7_ENST00000419127.1_Nonsense_Mutation_p.W678*			Q7RTY8	TMPS7_HUMAN	transmembrane protease, serine 7	804	Peptidase S1.				proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			breast(2)|endometrium(6)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	34						GATGGAAAATGGATTTTGACT	0.403000													39	56					0	0	1	0	0
ABCF1	23	broad.mit.edu	37	6	30557643	30557643	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:30557643G>A	ENST00000326195.8	+	22	2237	c.2125G>A	c.(2125-2127)Gag>Aag	p.E709K	ABCF1_ENST00000396515.4_Intron|ABCF1_ENST00000376545.3_Missense_Mutation_p.E671K	NM_001025091.1	NP_001020262.1	Q8NE71	ABCF1_HUMAN	ATP-binding cassette, sub-family F (GCN20), member 1	709	ABC transporter 2.				inflammatory response|translational initiation	nuclear envelope|nucleoplasm|polysomal ribosome	ATP binding|ATPase activity|protein binding|ribosome binding|translation activator activity|translation factor activity, nucleic acid binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(3)|skin(2)	21						GACGCCCACTGAGTACCTGCA	0.597000													104	87					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196620890	196620890	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:196620890C>T	ENST00000312428.6	-	62	11653	c.11553G>A	c.(11551-11553)gtG>gtA	p.V3851V	DNAH7_ENST00000409063.1_Silent_p.V334V	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3851					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						GGAAGTCATTCACATAGCTGC	0.383000													8	30					0	0	1	0	0
VARS	7407	broad.mit.edu	37	6	31747065	31747065	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:31747065G>A	ENST00000375663.3	-	29	3845	c.3405C>T	c.(3403-3405)ttC>ttT	p.F1135F		NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	1135					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	CCACTTCCAGGAAACCTGCCA	0.662000													18	20					0	0	1	0	0
CSRNP1	64651	broad.mit.edu	37	3	39184651	39184651	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:39184651G>A	ENST00000273153.5	-	5	1842	c.1665C>T	c.(1663-1665)tcC>tcT	p.S555S	CSRNP1_ENST00000514182.1_Silent_p.S555S	NM_033027.3	NP_149016.2	Q96S65	CSRN1_HUMAN	cysteine-serine-rich nuclear protein 1	555					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(5)|lung(3)|ovary(5)|skin(3)	24						AGCCCATGAGGGACTCCAGGA	0.597000													37	50					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36873775	36873775	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:36873775G>A	ENST00000301807.6	-	21	7414	c.5517C>T	c.(5515-5517)ttC>ttT	p.F1839F	TRANK1_ENST00000428977.2_Silent_p.F1839F|TRANK1_ENST00000429976.2_Silent_p.F2389F	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2389					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GGACATTCATGAAACGGAAAA	0.493000													40	68					0	0	1	0	0
MSRB3	253827	broad.mit.edu	37	12	65857044	65857044	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:65857044C>T	ENST00000308259.5	+	7	774	c.500C>T	c.(499-501)aCc>aTc	p.T167I	MSRB3_ENST00000535664.1_Missense_Mutation_p.T167I|MSRB3_ENST00000355192.3_Missense_Mutation_p.T174I	NM_001031679.2|NM_001193460.1	NP_001026849.1|NP_001180389.1	Q8IXL7	MSRB3_HUMAN	methionine sulfoxide reductase B3	174					protein repair	endoplasmic reticulum|mitochondrion	peptide-methionine-(S)-S-oxide reductase activity|protein-methionine-R-oxide reductase activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)	13			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.131)		AGCAGTGGCACCGCCGAGGGA	0.537000													36	32					0	0	1	0	0
ITSN2	50618	broad.mit.edu	37	2	24509190	24509190	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:24509190G>A	ENST00000355123.4	-	16	2197	c.1754C>T	c.(1753-1755)tCa>tTa	p.S585L	ITSN2_ENST00000361999.3_Missense_Mutation_p.S585L|ITSN2_ENST00000406921.3_Missense_Mutation_p.S585L	NM_006277.2	NP_006268.2	Q9NZM3	ITSN2_HUMAN	intersectin 2	585					endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(8)|large_intestine(11)|liver(3)|lung(28)|ovary(2)|stomach(1)	61	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTTTTCTAATGATTTTTTATG	0.323000													18	16					0	0	1	0	0
RP11-337C18.8	0	broad.mit.edu	37	1	146650172	146650172	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:146650172C>T	ENST00000607149.1	+	0	350																											TAGGTTTTTTCGATGATTCAT	0.438000													15	66					0	0	1	0	0
TCTN2	79867	broad.mit.edu	37	12	124191384	124191384	+	Silent	SNP	C	C	T	rs139902134		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:124191384C>T	ENST00000303372.5	+	16	2009	c.1881C>T	c.(1879-1881)ccC>ccT	p.P627P	TCTN2_ENST00000426174.2_Silent_p.P626P	NM_001143850.2|NM_024809.4	NP_001137322.1|NP_079085.2	Q96GX1	TECT2_HUMAN	tectonic family member 2	627					cilium assembly|smoothened signaling pathway	integral to membrane				breast(2)|cervix(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000163)|Epithelial(86;0.000502)|all cancers(50;0.00451)		CACAGTTACCCCACCCCCTGA	0.433000													11	38					0	0	1	0	0
OR5D13	390142	broad.mit.edu	37	11	55540972	55540972	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:55540972C>T	ENST00000361760.1	+	1	59	c.59C>T	c.(58-60)tCa>tTa	p.S20L		NM_001001967.1	NP_001001967.1	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D, member 13	20					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(20)|ovary(1)|pancreas(2)|skin(2)|stomach(1)|urinary_tract(1)	40		all_epithelial(135;0.196)				TTGGGTTTTTCAGAATACCCA	0.383000													45	66					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802564	185802564	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:185802564G>A	ENST00000302277.6	+	4	3035	c.2441G>A	c.(2440-2442)cGa>cAa	p.R814Q		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	814						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						AAACGGAGGCGAAAAAGAGGC	0.398000													31	29					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17131373	17131373	+	Missense_Mutation	SNP	C	C	T	rs144997343		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:17131373C>T	ENST00000418129.2	+	6	3440	c.2975C>T	c.(2974-2976)cCc>cTc	p.P992L	PLCL2_ENST00000432376.1_Missense_Mutation_p.P992L	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	1118					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						GAAGTCATACCCGAAAAAGCA	0.423000													18	24					0	0	1	0	0
PIGV	55650	broad.mit.edu	37	1	27121369	27121369	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:27121369G>A	ENST00000374145.1	+	3	1526	c.844G>A	c.(844-846)Gac>Aac	p.D282N	PIGV_ENST00000449950.2_Missense_Mutation_p.D54N|PIGV_ENST00000078527.4_Missense_Mutation_p.D282N	NM_001202554.1	NP_001189483.1	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class V	282					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|skin(2)	14		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		GTTAGCTGTAGACAAGGGCTA	0.507000													49	243					0	0	1	0	0
PCMTD1	115294	broad.mit.edu	37	8	52733173	52733173	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:52733173C>T	ENST00000360540.5	-	7	1218	c.812G>A	c.(811-813)aGg>aAg	p.R271K	PCMTD1_ENST00000522514.1_Missense_Mutation_p.R271K|PCMTD1_ENST00000544451.1_Missense_Mutation_p.R195K|PCMTD1_ENST00000519559.1_5'UTR	NM_052937.2	NP_443169.2	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	271						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	p.R271M(2)		NS(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(17)|prostate(2)|skin(8)|soft_tissue(1)	37		Lung NSC(129;0.0795)|all_lung(136;0.144)				GGGTGGAGCCCTTTGAGGAAT	0.423000													11	144					0	0	1	0	0
MREG	55686	broad.mit.edu	37	2	216809596	216809596	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:216809596G>A	ENST00000263268.6	-	5	930	c.635C>T	c.(634-636)cCa>cTa	p.P212L		NM_018000.2	NP_060470.2	Q8N565	MREG_HUMAN	melanoregulin	212						apical plasma membrane				large_intestine(1)|lung(2)	3		Renal(323;0.0328)		Epithelial(149;4.64e-07)|all cancers(144;5.56e-05)|LUSC - Lung squamous cell carcinoma(224;0.00832)|Lung(261;0.0111)		TTAGGGACTTGGAAACGGAAG	0.498000													14	23					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7083595	7083595	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:7083595T>G	ENST00000299481.4	+	10	3182	c.2836T>G	c.(2836-2838)Tgt>Ggt	p.C946G		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	946					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TAATGCATGTTGTCTGGATCT	0.403000													30	54					0	0	1	0	0
ANK3	288	broad.mit.edu	37	10	61956365	61956365	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:61956365G>A	ENST00000280772.1	-	15	1899	c.1708C>T	c.(1708-1710)Cat>Tat	p.H570Y	ANK3_ENST00000373827.2_Missense_Mutation_p.H564Y|ANK3_ENST00000503366.1_Missense_Mutation_p.H553Y	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	570					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GCTGCCACATGAAGAGGAGTA	0.388000													9	4					0	0	1	0	0
CNGB3	54714	broad.mit.edu	37	8	87751949	87751949	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:87751949C>T	ENST00000320005.5	-	2	192	c.145G>A	c.(145-147)Gaa>Aaa	p.E49K	CNGB3_ENST00000519777.1_5'UTR|RP11-386D6.1_ENST00000519041.1_RNA	NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	49					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						GATTTCTCTTCACCTTTGTTT	0.323000													15	19					0	0	1	0	0
PRDM9	56979	broad.mit.edu	37	5	23524449	23524449	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:23524449G>A	ENST00000296682.3	+	10	1139	c.957G>A	c.(955-957)gtG>gtA	p.V319V		NM_020227.2	NP_064612.2	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	319	SET.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(27)|lung(87)|ovary(6)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(11)	172						CCAGGTATGTGAACTGTGCCC	0.542000										HNSCC(3;0.000094)			22	52					0	0	1	0	0
FREM1	158326	broad.mit.edu	37	9	14775954	14775954	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:14775954G>A	ENST00000380881.4	-	26	5508	c.4693C>T	c.(4693-4695)Caa>Taa	p.Q1565*	FREM1_ENST00000380880.3_Nonsense_Mutation_p.Q1564*|FREM1_ENST00000422223.2_Nonsense_Mutation_p.Q1564*|FREM1_ENST00000380894.1_Nonsense_Mutation_p.Q100*			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1564					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		AAATTGTGTTGAAGTAGCCCT	0.562000													57	19					0	0	1	0	0
MIB2	142678	broad.mit.edu	37	1	1559299	1559299	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:1559299C>T	ENST00000357210.4	+	4	783	c.567C>T	c.(565-567)gaC>gaT	p.D189D	MIB2_ENST00000378710.3_Silent_p.D189D|MIB2_ENST00000504599.1_Silent_p.D145D|MIB2_ENST00000378708.1_Silent_p.D131D|MIB2_ENST00000355826.5_Silent_p.D232D|MIB2_ENST00000378712.1_Silent_p.D131D|MIB2_ENST00000520777.1_Silent_p.D246D|MIB2_ENST00000518681.1_Silent_p.D246D|MIB2_ENST00000360522.4_Silent_p.D189D|MIB2_ENST00000512004.1_3'UTR|MIB2_ENST00000505820.2_Silent_p.D246D	NM_080875.2	NP_543151.2	Q96AX9	MIB2_HUMAN	mindbomb E3 ubiquitin protein ligase 2	189					Notch signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade	endosome	actin binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|lung(7)|prostate(4)|upper_aerodigestive_tract(1)	18	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;6.04e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;5.26e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.54e-23)|GBM - Glioblastoma multiforme(42;9e-08)|Colorectal(212;0.000155)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00227)|STAD - Stomach adenocarcinoma(132;0.00644)|BRCA - Breast invasive adenocarcinoma(365;0.00786)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		ACGCCTTCGACCGCTACGAGA	0.687000													13	7					0	0	1	0	0
TMEM132B	114795	broad.mit.edu	37	12	126068437	126068437	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:126068437C>T	ENST00000299308.3	+	5	1327	c.1319C>T	c.(1318-1320)cCt>cTt	p.P440L		NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	440						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		ACTGGAAAGCCTGTTTCAGTT	0.522000													46	139					0	0	1	0	0
HCK	3055	broad.mit.edu	37	20	30662441	30662441	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:30662441G>A	ENST00000534862.1	+	6	648	c.285G>A	c.(283-285)tgG>tgA	p.W95*	HCK_ENST00000518730.1_Nonsense_Mutation_p.W93*|HCK_ENST00000375852.2_Nonsense_Mutation_p.W115*|HCK_ENST00000538448.1_Nonsense_Mutation_p.W94*|HCK_ENST00000520553.1_Nonsense_Mutation_p.W94*|HCK_ENST00000375862.2_Nonsense_Mutation_p.W114*	NM_001172132.1	NP_001165603.1	P08631	HCK_HUMAN	hemopoietic cell kinase	115	SH3.				interspecies interaction between organisms|mesoderm development|regulation of defense response to virus by virus|viral reproduction	caveola|cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			NS(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(18)|ovary(2)|pancreas(1)|prostate(2)|skin(4)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGGAGTGGTGGAAGGCTCGAT	0.547000													11	151					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176992707	176992707	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:176992707C>T	ENST00000367654.2	-	7	1284	c.1270_splice	c.e7-1	p.G424_splice	ASTN1_ENST00000361833.2_Splice_Site_p.G424_splice|ASTN1_ENST00000367657.3_Splice_Site_p.G424_splice|ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000424564.2_Splice_Site_p.G424_splice			O14525	ASTN1_HUMAN	astrotactin 1	424					cell migration|neuron cell-cell adhesion	integral to membrane		p.G424V(1)		NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GAAGCGGCTCCCTGCAGGGTG	0.552000													23	17					0	0	1	0	0
LCN1	3933	broad.mit.edu	37	9	138416708	138416708	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:138416708G>A	ENST00000263598.2	+	5	496	c.436G>A	c.(436-438)Gag>Aag	p.E146K	LCN1_ENST00000371781.3_Missense_Mutation_p.E146K	NM_001252617.1|NM_001252618.1|NM_001252619.1|NM_002297.3	NP_001239546.1|NP_001239547.1|NP_001239548.1|NP_002288.1	P31025	LCN1_HUMAN	lipocalin 1	146					proteolysis|response to stimulus|sensory perception of taste	extracellular region	cysteine-type endopeptidase inhibitor activity|transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)	13		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.54e-08)|Epithelial(140;5.25e-08)|all cancers(34;9.27e-07)|READ - Rectum adenocarcinoma(205;0.155)		GGAAGCCTTGGAGGACTTTGA	0.647000													9	7					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209110041	209110041	+	Splice_Site	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:209110041A>G	ENST00000415913.1	-	5	902		c.e5+1		IDH1_ENST00000446179.1_Splice_Site|IDH1_ENST00000345146.2_Splice_Site			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble						2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity			NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		AGTCATACATACCTTCAAAGT	0.328000			Mis		gliobastoma								23	36					0	0	1	0	0
ASB10	136371	broad.mit.edu	37	7	150878479	150878479	+	Silent	SNP	G	G	A	rs149386099	byFrequency	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:150878479G>A	ENST00000422024.1	-	3	911	c.786C>T	c.(784-786)acC>acT	p.T262T	ASB10_ENST00000420175.2_Silent_p.T217T|ASB10_ENST00000434669.1_Silent_p.T262T|ASB10_ENST00000377867.3_Silent_p.T202T|ASB10_ENST00000275838.1_Silent_p.T217T	NM_001142459.1	NP_001135931.2	Q8WXI3	ASB10_HUMAN	ankyrin repeat and SOCS box containing 10	217					intracellular signal transduction					NS(1)|endometrium(2)|lung(7)|skin(2)	12			OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CATGCAAAGGGGTCTCCTCTT	0.632000													15	24					0	0	1	0	0
KRT34	3885	broad.mit.edu	37	17	39538602	39538602	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:39538602G>A	ENST00000394001.1	-	1	53	c.23C>T	c.(22-24)cCc>cTc	p.P8L		NM_021013.3	NP_066293.2	O76011	KRT34_HUMAN	keratin 34	8	Head.				epidermis development	intermediate filament	protein binding|structural molecule activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		Breast(137;0.000496)				ATTAATTGTGGGTGGGGGCTT	0.458000													23	42					0	0	1	0	0
TUBGCP4	27229	broad.mit.edu	37	15	43696745	43696745	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:43696745G>A	ENST00000564079.1	+	17	2223	c.1983G>A	c.(1981-1983)ctG>ctA	p.L661L	TUBGCP4_ENST00000260383.7_Silent_p.L662L|TUBGCP4_ENST00000399460.3_3'UTR	NM_014444.2	NP_055259.2	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	662					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			breast(1)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(5)|lung(3)|ovary(4)|prostate(2)|upper_aerodigestive_tract(2)	21		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		GTGGAACTCTGGGCAGGTAGG	0.408000													14	35					0	0	1	0	0
NEUROD4	58158	broad.mit.edu	37	12	55421006	55421006	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:55421006G>A	ENST00000242994.3	+	2	1161	c.783G>A	c.(781-783)ggG>ggA	p.G261G		NM_021191.2	NP_067014.2	Q9HD90	NDF4_HUMAN	neuronal differentiation 4	261					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(3)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	41						GCATCAGTGGGAACTTCTCCT	0.502000													34	71					0	0	1	0	0
SELPLG	6404	broad.mit.edu	37	12	109017137	109017137	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:109017137G>A	ENST00000388962.3	-	3	1076	c.917C>T	c.(916-918)tCt>tTt	p.S306F	SELPLG_ENST00000550948.1_Missense_Mutation_p.S316F|SELPLG_ENST00000228463.6_Missense_Mutation_p.S332F	NM_003006.4	NP_002997.2	Q14242	SELPL_HUMAN	selectin P ligand	316					blood coagulation|cellular response to interleukin-6	integral to plasma membrane|membrane fraction	bacterial cell surface binding|receptor binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|prostate(3)|skin(1)	12						CTGCTTCACAGAGATGTGGTC	0.577000													20	17					0	0	1	0	0
GLYATL2	219970	broad.mit.edu	37	11	58602305	58602305	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:58602305C>T	ENST00000287275.1	-	6	872	c.482G>A	c.(481-483)gGa>gAa	p.G161E	GLYATL2_ENST00000533636.1_5'UTR|GLYATL2_ENST00000532258.1_Missense_Mutation_p.G161E	NM_145016.3	NP_659453.3	Q8WU03	GLYL2_HUMAN	glycine-N-acyltransferase-like 2	161						mitochondrion	glycine N-acyltransferase activity			breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	23		Breast(21;0.0044)|all_epithelial(135;0.0216)			Glycine(DB00145)	TGAAAAGTTTCCTTCCCTGTG	0.348000													13	18					0	0	1	0	0
GAA	2548	broad.mit.edu	37	17	78082400	78082400	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:78082400C>T	ENST00000302262.3	+	7	1407	c.1188C>T	c.(1186-1188)ttC>ttT	p.F396F	GAA_ENST00000390015.3_Silent_p.F396F	NM_000152.3	NP_000143.2	P10253	LYAG_HUMAN	glucosidase, alpha; acid	396					cardiac muscle contraction|diaphragm contraction|glycogen catabolic process|lysosome organization|tongue morphogenesis|vacuolar sequestering|ventricular cardiac muscle tissue morphogenesis	lysosomal membrane	carbohydrate binding|maltose alpha-glucosidase activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|lung(6)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	21	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)		Acarbose(DB00284)	GGGCCCACTTCCCCCTGGTGA	0.687000													18	30					0	0	1	0	0
GRIP2	80852	broad.mit.edu	37	3	14536360	14536360	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:14536360C>T	ENST00000273083.3	-	0	3025							Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2						synaptic transmission	cytosol|plasma membrane	protein binding			endometrium(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(1)|prostate(5)|skin(1)	25						CCTGCAGGACCCTGTCGAAGG	0.602000													12	20					0	0	1	0	0
IGSF9B	22997	broad.mit.edu	37	11	133795856	133795856	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:133795856G>A	ENST00000321016.8	-	14	2042	c.1812C>T	c.(1810-1812)ttC>ttT	p.F604F	IGSF9B_ENST00000533871.2_Silent_p.F604F			Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	604						integral to membrane|plasma membrane				breast(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(18)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	44	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		TTGTAATAGGGAATGCTGCGG	0.642000													3	13					0	0	1	0	0
HYAL3	8372	broad.mit.edu	37	3	50332361	50332361	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:50332361G>A	ENST00000336307.1	-	2	945	c.673C>T	c.(673-675)Ctt>Ttt	p.L225F	HYAL3_ENST00000513170.1_Intron|HYAL3_ENST00000359051.3_Missense_Mutation_p.L225F|HYAL3_ENST00000450982.1_Missense_Mutation_p.L225F|HYAL3_ENST00000415204.1_Intron	NM_001200029.1|NM_003549.3	NP_001186958.1|NP_003540.2	O43820	HYAL3_HUMAN	hyaluronoglucosaminidase 3	225					carbohydrate metabolic process	extracellular region|lysosome	hyalurononglucosaminidase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|lung(5)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TTGCGGGCAAGGGTGGCTGCA	0.632000													38	56					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39945566	39945566	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:39945566C>T	ENST00000564288.1	+	98	22832	c.22055C>T	c.(22054-22056)tCc>tTc	p.S7352F	MACF1_ENST00000372915.3_Missense_Mutation_p.S7222F|MACF1_ENST00000567887.1_Missense_Mutation_p.S7389F|MACF1_ENST00000545844.1_Missense_Mutation_p.S5264F|MACF1_ENST00000361689.2_Missense_Mutation_p.S5264F|MACF1_ENST00000317713.7_Missense_Mutation_p.S5264F|MACF1_ENST00000539005.1_Missense_Mutation_p.S5134F|MACF1_ENST00000289893.4_Missense_Mutation_p.S5772F			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	7222	C-terminal tail (By similarity).				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GGTCGAAGGTCCAAACCATCT	0.537000													14	68					0	0	1	0	0
CCDC102B	79839	broad.mit.edu	37	18	66564557	66564557	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:66564557C>T	ENST00000360242.5	+	6	1272	c.1155C>T	c.(1153-1155)atC>atT	p.I385I	CCDC102B_ENST00000319445.6_Silent_p.I385I|CCDC102B_ENST00000358653.5_Silent_p.I385I|CCDC102B_ENST00000584156.1_Silent_p.I385I|CCDC102B_ENST00000577772.1_3'UTR	NM_024781.2	NP_079057.2	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	385										breast(2)|endometrium(3)|large_intestine(5)|lung(19)|ovary(1)|skin(5)|stomach(1)	36		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				GGCTGAAGATCCAGGTGAAAG	0.388000													55	66					0	0	1	0	0
CUBN	8029	broad.mit.edu	37	10	17142112	17142112	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:17142112G>A	ENST00000377833.4	-	14	1722	c.1657C>T	c.(1657-1659)Ctc>Ttc	p.L553F		NM_001081.3	NP_001072.2	O60494	CUBN_HUMAN	cubilin (intrinsic factor-cobalamin receptor)	553	CUB 1.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			breast(8)|central_nervous_system(4)|cervix(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(42)|liver(1)|lung(107)|ovary(9)|pancreas(2)|prostate(3)|skin(9)|stomach(3)|upper_aerodigestive_tract(11)|urinary_tract(8)	241					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	TCATGAGGGAGGCTGGAGCCA	0.428000													20	38					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129618904	129618904	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:129618904C>T	ENST00000421865.2	+	21	2980	c.2931C>T	c.(2929-2931)ttC>ttT	p.F977F		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	977	Laminin EGF-like 10.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CTAAGTCATTCGACTGTGAAG	0.502000													24	19					0	0	1	0	0
GPC4	2239	broad.mit.edu	37	X	132458544	132458544	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:132458544C>T	ENST00000370828.3	-	3	864	c.340G>A	c.(340-342)Gaa>Aaa	p.E114K	GPC4_ENST00000535467.1_Missense_Mutation_p.E44K	NM_001448.2	NP_001439.2	O75487	GPC4_HUMAN	glypican 4	114					anatomical structure morphogenesis|cell proliferation	anchored to membrane|external side of plasma membrane|extracellular space|insoluble fraction|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|skin(1)|upper_aerodigestive_tract(1)	28	Acute lymphoblastic leukemia(192;0.000127)					TCTGCATTTTCAAGTAGTTCT	0.303000													60	66					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84453717	84453717	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:84453717G>A	ENST00000377084.2	-	1	2811	c.1926C>T	c.(1924-1926)atC>atT	p.I642I		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	642						integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		GGTTCCTCAGGATAAACACGA	0.562000													19	31					0	0	1	0	0
TMEM65	157378	broad.mit.edu	37	8	125335573	125335573	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:125335573G>A	ENST00000297632.6	-	4	995	c.461C>T	c.(460-462)tCa>tTa	p.S154L		NM_194291.2	NP_919267.2	Q6PI78	TMM65_HUMAN	transmembrane protein 65	154						integral to membrane				cervix(1)|endometrium(1)|large_intestine(2)|lung(1)|prostate(1)	6	Lung NSC(37;1.18e-11)|Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			TGCCATAGTTGAAATTCCCAA	0.254000													3	13					0	0	1	0	0
BPIFB6	128859	broad.mit.edu	37	20	31627211	31627211	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:31627211C>T	ENST00000349552.1	+	10	959	c.959C>T	c.(958-960)cCt>cTt	p.P320L		NM_174897.2	NP_777557.1	Q8NFQ5	BPIL3_HUMAN	BPI fold containing family B, member 6	320						extracellular region	lipid binding										ATAAAGAAGCCTCCCAAGGTC	0.547000													38	162					0	0	1	0	0
ZBTB39	9880	broad.mit.edu	37	12	57397398	57397398	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:57397398G>A	ENST00000300101.2	-	2	1389	c.1304C>T	c.(1303-1305)cCc>cTc	p.P435L		NM_014830.2	NP_055645.1	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	435					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|liver(1)|lung(3)|prostate(1)	16						CCCTGGCAGGGGATCGTTGGG	0.532000													16	28					0	0	1	0	0
OR8H2	390151	broad.mit.edu	37	11	55872708	55872708	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:55872708C>T	ENST00000313503.1	+	1	190	c.190C>T	c.(190-192)Ctt>Ttt	p.L64F		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	64					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L64F(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					GTATTTTTTCCTTACTCACCT	0.423000										HNSCC(53;0.14)			115	161					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	78649406	78649406	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:78649406C>T	ENST00000436010.2	-	28	5678	c.4681G>A	c.(4681-4683)Gat>Aat	p.D1561N	ROBO1_ENST00000467549.1_Missense_Mutation_p.D1500N|ROBO1_ENST00000464233.1_Missense_Mutation_p.D1600N|ROBO1_ENST00000495273.1_Missense_Mutation_p.D1555N|ROBO1_ENST00000466906.1_5'UTR			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	1600					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		GAACTGGGATCTCTGGGATTA	0.378000													23	45					0	0	1	0	0
CYP3A43	64816	broad.mit.edu	37	7	99454460	99454460	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:99454460G>A	ENST00000354829.2	+	9	906	c.803G>A	c.(802-804)cGa>cAa	p.R268Q	CYP3A43_ENST00000477658.1_3'UTR|CYP3A43_ENST00000312017.5_Missense_Mutation_p.R268Q|CYP3A43_ENST00000222382.5_Missense_Mutation_p.R268Q|CYP3A43_ENST00000444905.1_Missense_Mutation_p.R15Q|CYP3A43_ENST00000415413.1_Missense_Mutation_p.R57Q|CYP3A43_ENST00000417625.1_Missense_Mutation_p.R158Q|CYP3A43_ENST00000342499.4_Missense_Mutation_p.R128Q	NM_022820.3|NM_057095.1	NP_073731.1|NP_476436.1	Q9HB55	CP343_HUMAN	cytochrome P450, family 3, subfamily A, polypeptide 43	268			Missing (in allele CYP3A43*2).		xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|skin(1)	19	Esophageal squamous(72;0.0166)|Lung NSC(181;0.0211)|all_lung(186;0.0323)				Cetirizine(DB00341)|Doxycycline(DB00254)	TTCCAGCATCGAGTAGATTTC	0.433000													30	53					0	0	1	0	0
CLSTN3	9746	broad.mit.edu	37	12	7293876	7293876	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:7293876C>T	ENST00000537408.1	+	8	1936	c.1398C>T	c.(1396-1398)ctC>ctT	p.L466L	CLSTN3_ENST00000266546.6_Silent_p.L454L			Q9BQT9	CSTN3_HUMAN	calsyntenin 3	454					homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(7)|prostate(1)|skin(1)	33						CTCTGAACCTCGAGTTCCCCA	0.567000											OREG0021650	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	111	102					0	0	1	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55020238	55020238	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:55020238T>C	ENST00000324000.3	+	1	2195	c.161T>C	c.(160-162)aTg>aCg	p.M54T		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	54					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		CGAATGTACATGTTCCACGCG	0.592000													37	51					0	0	1	0	0
COL1A1	1277	broad.mit.edu	37	17	48272128	48272128	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:48272128C>T	ENST00000225964.5	-	21	1533	c.1415G>A	c.(1414-1416)cGa>cAa	p.R472Q		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	472	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	GGGTTCACCTCGAGCTCCTCG	0.697000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						4	4					0	0	1	0	0
OR8H1	219469	broad.mit.edu	37	11	56057777	56057777	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:56057777C>T	ENST00000313022.2	-	1	789	c.762G>A	c.(760-762)atG>atA	p.M254I		NM_001005199.1	NP_001005199.1	Q8NGG4	OR8H1_HUMAN	olfactory receptor, family 8, subfamily H, member 1	254					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	43	Esophageal squamous(21;0.00448)					AAGTAAAAATCATAGTTCCAT	0.368000													25	38					0	0	1	0	0
C3	718	broad.mit.edu	37	19	6694442	6694442	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:6694442C>T	ENST00000245907.6	-	24	3246	c.3154_splice	c.e24+1	p.G1052_splice		NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1052					complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		GGGAGCCCACCCTTCTTGATG	0.627000													12	35					0	0	1	0	0
PCNXL4	64430	broad.mit.edu	37	14	60585065	60585065	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:60585065C>T	ENST00000406854.1	+	7	2151	c.1597C>T	c.(1597-1599)Cgt>Tgt	p.R533C	PCNXL4_ENST00000317623.4_Missense_Mutation_p.R299C|PCNXL4_ENST00000404681.2_Missense_Mutation_p.R533C|PCNXL4_ENST00000406949.1_Missense_Mutation_p.R299C					pecanex-like 4 (Drosophila)																		CATACGTGATCGTTTGATTCA	0.323000													14	2					0	0	1	0	0
HSFY1P1	27437	broad.mit.edu	37	22	17308603	17308603	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:17308603C>T	ENST00000425038.1	+	0	240					NR_003607.1																						CCACAAGGATCCTTGATAAAA	0.398000													4	13					0	0	1	0	0
NRAP	4892	broad.mit.edu	37	10	115409833	115409833	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:115409833C>T	ENST00000369358.4	-	9	1095	c.851G>A	c.(850-852)gGc>gAc	p.G284D	NRAP_ENST00000369360.3_Missense_Mutation_p.G284D|NRAP_ENST00000359988.3_Missense_Mutation_p.G284D|NRAP_ENST00000360478.3_Missense_Mutation_p.G284D			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	284						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		TGTCAAGATGCCCTCAGCTCC	0.458000													7	95					0	0	1	0	0
ZNF730	100129543	broad.mit.edu	37	19	23328171	23328171	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:23328171G>A	ENST00000597761.2	+	4	524	c.325G>A	c.(325-327)Gag>Aag	p.E109K		NM_001277403.1	NP_001264332.1			zinc finger protein 730									p.E109K(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|lung(7)|pancreas(1)|stomach(2)|urinary_tract(1)	16						ATGTAGACATGAGAATTTACT	0.333000													5	11					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039183	11039183	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:11039183G>A	ENST00000470054.1	-	0	1020									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TAGTGGAAGAGTGACAGATTC	0.423000													15	221					0	0	1	0	0
IGSF1	3547	broad.mit.edu	37	X	130410155	130410155	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:130410155G>A	ENST00000370904.1	-	21	3559	c.2649C>T	c.(2647-2649)atC>atT	p.I883I	IGSF1_ENST00000467244.1_5'UTR|IGSF1_ENST00000361420.3_Silent_p.I892I|IGSF1_ENST00000370910.1_Silent_p.I883I|IGSF1_ENST00000370903.3_Silent_p.I897I			Q8N6C5	IGSF1_HUMAN	immunoglobulin superfamily, member 1	892	Ig-like C2-type 9.				regulation of transcription, DNA-dependent	extracellular region|integral to membrane	inhibin beta-A binding|inhibin beta-B binding			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(15)|liver(1)|lung(37)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)	78						GGCAGCGCAGGATCACACTCT	0.537000													50	8					0	0	1	0	0
PCDHB8	56128	broad.mit.edu	37	5	140558185	140558185	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140558185G>A	ENST00000239444.2	+	1	815	c.570G>A	c.(568-570)agG>agA	p.R190R		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		190	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GTGATGGCAGGAAATACCCAG	0.502000													6	70					0	0	1	0	0
PRAMEF1	65121	broad.mit.edu	37	1	12853586	12853586	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:12853586G>A	ENST00000332296.7	+	2	313	c.210G>A	c.(208-210)atG>atA	p.M70I		NM_023013.2	NP_075389.1	O95521	PRAM1_HUMAN	PRAME family member 1	70										cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	35	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00812)|Colorectal(212;4.88e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000194)|COAD - Colon adenocarcinoma(227;0.000241)|BRCA - Breast invasive adenocarcinoma(304;0.000293)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		GATCACTGATGAAGACGCTTC	0.557000													24	147					0	0	1	0	0
HVCN1	84329	broad.mit.edu	37	12	111089052	111089052	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:111089052G>A	ENST00000356742.5	-	5	1366	c.613C>T	c.(613-615)Cgg>Tgg	p.R205W	HVCN1_ENST00000242607.8_Missense_Mutation_p.R205W|HVCN1_ENST00000548312.1_Missense_Mutation_p.R205W|HVCN1_ENST00000439744.2_Missense_Mutation_p.R185W			Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	205					response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	19						CGCCACAGCCGGAGCAGAATC	0.602000													3	39					0	0	1	0	0
CALCB	797	broad.mit.edu	37	11	15098834	15098834	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:15098834C>T	ENST00000523376.1	+	9	1522	c.260C>T	c.(259-261)tCc>tTc	p.S87F	CALCB_ENST00000533448.1_Missense_Mutation_p.S76F|CALCB_ENST00000324229.6_Missense_Mutation_p.S76F			P10092	CALCB_HUMAN	calcitonin-related polypeptide beta	76					cellular calcium ion homeostasis|signal transduction|vasodilation	extracellular region|soluble fraction	neuropeptide hormone activity			endometrium(1)|large_intestine(1)|lung(1)|skin(2)	5						CAAATCAGCTCCGCTGCCCAG	0.537000													22	31					0	0	1	0	0
ITGB5	3693	broad.mit.edu	37	3	124567296	124567296	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:124567296G>A	ENST00000296181.4	-	4	767	c.471C>T	c.(469-471)atC>atT	p.I157I	ITGB5_ENST00000488466.1_5'UTR	NM_002213.3	NP_002204.2	P18084	ITB5_HUMAN	integrin, beta 5	157	VWFA.				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)	30				GBM - Glioblastoma multiforme(114;0.163)		CCAGGCTCCGGATATTGTCCA	0.532000													59	54					0	0	1	0	0
MICALCL	84953	broad.mit.edu	37	11	12341346	12341346	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:12341346C>T	ENST00000256186.2	+	4	1821	c.1530C>T	c.(1528-1530)tcC>tcT	p.S510S		NM_032867.2	NP_116256.2	Q6ZW33	MICLK_HUMAN	MICAL C-terminal like	510					cell differentiation|multicellular organismal development|spermatogenesis	cytoplasm	mitogen-activated protein kinase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(5)|lung(5)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	30				Epithelial(150;0.00177)		CCCAGCTTTCCTTGCAGTTAA	0.522000													30	66					0	0	1	0	0
SCN4A	6329	broad.mit.edu	37	17	62018565	62018565	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:62018565C>T	ENST00000578147.1	-	24	5153	c.5077G>A	c.(5077-5079)Gaa>Aaa	p.E1693K	SCN4A_ENST00000435607.1_Missense_Mutation_p.E1693K			P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit	1693					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.E1693K(1)		breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	GCGTCCATTTCCCCAGAGTCA	0.577000													32	44					0	0	1	0	0
INTS5	80789	broad.mit.edu	37	11	62416552	62416552	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:62416552G>A	ENST00000330574.2	-	2	1052	c.1000C>T	c.(1000-1002)Ctt>Ttt	p.L334F		NM_030628.1	NP_085131.1	Q6P9B9	INT5_HUMAN	integrator complex subunit 5	334					snRNA processing	integral to membrane|integrator complex	protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(20)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	36						GTGGCCTGAAGGGAGGGGTCC	0.632000													33	135					0	0	1	0	0
SPAM1	6677	broad.mit.edu	37	7	123593772	123593772	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:123593772C>T	ENST00000340011.5	+	3	505	c.148C>T	c.(148-150)Ctc>Ttc	p.L50F	SPAM1_ENST00000439500.1_Missense_Mutation_p.L50F|SPAM1_ENST00000402183.2_Missense_Mutation_p.L50F|SPAM1_ENST00000223028.7_Missense_Mutation_p.L50F|SPAM1_ENST00000460182.1_Missense_Mutation_p.L50F	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	50					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	TGTGCCTTTCCTCTGGGCCTG	0.443000													15	18					0	0	1	0	0
MAP3K11	4296	broad.mit.edu	37	11	65366992	65366992	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:65366992G>A	ENST00000309100.3	-	9	2564	c.2079C>T	c.(2077-2079)tcC>tcT	p.S693S	MAP3K11_ENST00000534432.1_5'UTR|MAP3K11_ENST00000532507.1_Silent_p.S109S|MAP3K11_ENST00000530153.1_Silent_p.S436S	NM_002419.3	NP_002410.1	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase 11	693	Pro-rich.				activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(14)|skin(1)	24						AGATGAGCGGGGAAGGGGGCG	0.726000													23	29					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24833351	24833351	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:24833351C>T	ENST00000376451.2	+	14	4461	c.4201C>T	c.(4201-4203)Ccg>Tcg	p.P1401S	KIAA1217_ENST00000307544.6_Intron|KIAA1217_ENST00000396446.1_Intron|KIAA1217_ENST00000376452.3_Intron|KIAA1217_ENST00000396445.1_Intron|KIAA1217_ENST00000376454.3_Missense_Mutation_p.P1718S|KIAA1217_ENST00000458595.1_Intron|KIAA1217_ENST00000376462.1_Intron			Q5T5P2	SKT_HUMAN	KIAA1217	1718					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CTTGCTAGTTCCGGATGAAGG	0.512000													23	11					0	0	1	0	0
OR52H1	390067	broad.mit.edu	37	11	5566080	5566080	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:5566080G>A	ENST00000322653.4	-	1	699	c.674C>T	c.(673-675)tCc>tTc	p.S225F	HBG2_ENST00000380259.2_Intron	NM_001005289.1	NP_001005289.1	Q8NGJ2	O52H1_HUMAN	olfactory receptor, family 52, subfamily H, member 1	225					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;5.33e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GTGTGCGTAGGAAACAGCAAT	0.512000													17	29					0	0	1	0	0
IGHV3-15	28448	broad.mit.edu	37	14	106610591	106610591	+	RNA	SNP	C	C	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:106610591C>A	ENST00000390603.2	-	0	158																											AAGCCTCCCCCAGACTCCACC	0.557000													68	27					3.56841e-20	3.61588e-20	1	1	0
EXOSC10	5394	broad.mit.edu	37	1	11158087	11158087	+	Silent	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:11158087A>G	ENST00000544779.1	-	2	243	c.238T>C	c.(238-240)Ttg>Ctg	p.L80L	EXOSC10_ENST00000376936.4_Silent_p.L80L|EXOSC10_ENST00000304457.7_Silent_p.L80L			Q01780	EXOSX_HUMAN	exosome component 10	80					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|stomach(3)|upper_aerodigestive_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		CACTGAAGCAACCTGTCTCCC	0.383000													17	9					0	0	1	0	0
RBM5	10181	broad.mit.edu	37	3	50140565	50140565	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:50140565C>T	ENST00000347869.3	+	7	708	c.533C>T	c.(532-534)cCc>cTc	p.P178L		NM_005778.3	NP_005769.1	P52756	RBM5_HUMAN	RNA binding motif protein 5	178	RRM 1.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			breast(2)|cervix(2)|endometrium(3)|large_intestine(4)|lung(6)|prostate(2)	19				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TATAGCAATCCCAGACCTAAG	0.348000													36	67					0	0	1	0	0
AKAP3	10566	broad.mit.edu	37	12	4736456	4736456	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:4736456G>A	ENST00000545990.2	-	5	2136	c.1612C>T	c.(1612-1614)Cac>Tac	p.H538Y	AKAP3_ENST00000228850.1_Missense_Mutation_p.H538Y	NM_001278309.1	NP_001265238.1	O75969	AKAP3_HUMAN	A kinase (PRKA) anchor protein 3	538					acrosome reaction|cellular component movement	acrosomal vesicle	protein kinase A binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|liver(1)|lung(17)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	51						TGGGCCAGGTGATATTGAATC	0.522000													3	24					0	0	1	0	0
SPATA21	374955	broad.mit.edu	37	1	16736209	16736209	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:16736209G>A	ENST00000335496.1	-	6	956	c.474C>T	c.(472-474)gtC>gtT	p.V158V	SPATA21_ENST00000540400.1_Silent_p.V135V|SPATA21_ENST00000466212.1_5'UTR	NM_198546.1	NP_940948.1	Q7Z572	SPT21_HUMAN	spermatogenesis associated 21	158	Pro-rich.						calcium ion binding			breast(1)|endometrium(2)|lung(8)|ovary(2)|pancreas(3)|stomach(1)|urinary_tract(2)	19		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.15e-05)|BRCA - Breast invasive adenocarcinoma(304;4.2e-05)|Kidney(64;0.000183)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(313;0.0122)|READ - Rectum adenocarcinoma(331;0.0651)		TGGAGGTGGGGACCGGGGCTC	0.692000													5	23					0	0	1	0	0
OR51D1	390038	broad.mit.edu	37	11	4661061	4661061	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:4661061C>T	ENST00000357605.2	+	1	117	c.41C>T	c.(40-42)tCa>tTa	p.S14L		NM_001004751.2	NP_001004751.1	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D, member 1	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|liver(2)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	27		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATAGCCACTTCAAATGGAAAT	0.473000													46	72					0	0	1	0	0
SLC25A52	147407	broad.mit.edu	37	18	29339842	29339842	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:29339842C>T	ENST00000269205.5	-	1	1001	c.813G>A	c.(811-813)cgG>cgA	p.R271R	SLC25A52_ENST00000579441.2_Silent_p.R261R	NM_001034172.2	NP_001029344.3	Q3SY17	MCAR2_HUMAN	solute carrier family 25, member 52	261					transport	integral to membrane|mitochondrial inner membrane											GTTTTCTGTCCCGTTCCAGCC	0.408000													10	27					0	0	1	0	0
SIGLEC6	946	broad.mit.edu	37	19	52033753	52033753	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:52033753G>A	ENST00000359982.4	-	4	870	c.725C>T	c.(724-726)cCt>cTt	p.P242L	SIGLEC6_ENST00000425629.3_Intron|SIGLEC6_ENST00000436458.1_Intron|SIGLEC6_ENST00000391797.3_Intron|SIGLEC6_ENST00000343300.4_Intron|SIGLEC6_ENST00000346477.3_Intron	NM_001177548.1	NP_001171019.1	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	236	Ig-like C2-type 2.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GGTGGAAAGAGGTGGCCGCCT	0.582000													15	18					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43360272	43360272	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:43360272C>T	ENST00000395891.1	+	5	996	c.391C>T	c.(391-393)Cgt>Tgt	p.R131C	HECW1_ENST00000453890.1_Missense_Mutation_p.R131C	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	131					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CTATAAAAACCGTGGAGTCAA	0.458000													17	19					0	0	1	0	0
SCRN2	90507	broad.mit.edu	37	17	45917580	45917580	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:45917580G>A	ENST00000407215.3	-	3	414	c.333C>T	c.(331-333)gcC>gcT	p.A111A	SCRN2_ENST00000290216.9_Silent_p.A111A|SCRN2_ENST00000584123.1_Silent_p.A119A			Q96FV2	SCRN2_HUMAN	secernin 2	111					proteolysis		dipeptidase activity			cervix(1)|kidney(2)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	14						TGCCCAGCAGGGCTTCCCCCT	0.602000													47	53					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21826263	21826263	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:21826263G>A	ENST00000328843.6	+	60	9671	c.9640G>A	c.(9640-9642)Gcc>Acc	p.A3214T	DNAH11_ENST00000409508.3_Missense_Mutation_p.A3207T			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3214	Stalk (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						TGAGCTGAAAGCCTTTCCCAA	0.517000									Kartagener syndrome				34	68					0	0	1	0	0
FUS	2521	broad.mit.edu	37	16	31198144	31198144	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:31198144C>T	ENST00000254108.7	+	7	891	c.786C>T	c.(784-786)ttC>ttT	p.F262F	FUS_ENST00000568685.1_Silent_p.F262F|FUS_ENST00000380244.3_Silent_p.F261F|FUS_ENST00000474990.1_3'UTR	NM_001170634.1|NM_001170937.1|NM_004960.3	NP_001164105.1|NP_001164408.1|NP_004951.1	P35637	FUS_HUMAN	fused in sarcoma	262	Gly-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/ERG(167)|FUS/DDIT3(631)|FUS/FEV(2)|FUS/ATF1(4)|FUS/CREB3L1(6)|FUS/CREB3L2(158)	breast(3)|endometrium(5)|kidney(3)|large_intestine(1)|lung(5)|prostate(3)|skin(1)|urinary_tract(1)	22		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		GTGGTGGCTTCAATAAATTTG	0.388000			T	"""DDIT3, ERG, FEV, ATF1, CREB3L2, CREB3L1"""	"""liposarcoma, AML, Ewing sarcoma, angiomatoid fibrous histiocytoma, fibromyxoid sarcoma"""								28	26					0	0	1	0	0
SAMD9L	219285	broad.mit.edu	37	7	92760570	92760570	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:92760570G>A	ENST00000318238.4	-	5	5931	c.4715C>T	c.(4714-4716)tCc>tTc	p.S1572F	SAMD9L_ENST00000437805.1_Missense_Mutation_p.S1572F|SAMD9L_ENST00000411955.1_Missense_Mutation_p.S1572F	NM_152703.2	NP_689916.2	Q8IVG5	SAM9L_HUMAN	sterile alpha motif domain containing 9-like	1572										central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(23)|liver(2)|lung(31)|ovary(5)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	88	all_cancers(62;4.15e-11)|all_epithelial(64;2.29e-10)|Breast(17;0.000675)|Lung NSC(181;0.0755)|all_lung(186;0.0989)		STAD - Stomach adenocarcinoma(171;0.000302)			GCCTTCAATGGAAAATCCTAG	0.328000													11	21					0	0	1	0	0
ZNF768	79724	broad.mit.edu	37	16	30536878	30536878	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:30536878G>A	ENST00000380412.5	-	2	758	c.583C>T	c.(583-585)Ctg>Ttg	p.L195L	ZNF768_ENST00000562803.1_Silent_p.L164L	NM_024671.3	NP_078947.3	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	195					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						AAGGAGTCCAGGGGGTGAACT	0.552000													63	81					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30092869	30092869	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:30092869G>A	ENST00000567636.1	+	0	1244					NR_003558.1																						TGATGAAGATGATTCTGATGA	0.458000													16	15					0	0	1	0	0
C1QTNF9B	387911	broad.mit.edu	37	13	24465894	24465894	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:24465894C>T	ENST00000382137.3	-	3	604	c.536G>A	c.(535-537)gGa>gAa	p.G179E	C1QTNF9B_ENST00000382057.3_Intron|C1QTNF9B_ENST00000382140.2_Missense_Mutation_p.G179E|C1QTNF9B-AS1_ENST00000435039.2_RNA|C1QTNF9B_ENST00000556521.1_Intron|C1QTNF9B-AS1_ENST00000382133.4_RNA|C1QTNF9B_ENST00000382145.1_Intron|C1QTNF9B-AS1_ENST00000417034.1_RNA	NM_001007537.1	NP_001007538.1	B2RNN3	C1T9B_HUMAN	C1q and tumor necrosis factor related protein 9B	179	Collagen-like 3.					collagen				breast(1)|central_nervous_system(1)|large_intestine(3)|lung(1)	6						GCCTCTTATTCCCCGGACTCC	0.592000													17	64					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94519599	94519599	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:94519599C>T	ENST00000375708.3	-	3	616	c.418G>A	c.(418-420)Ggg>Agg	p.G140R	ROR2_ENST00000375715.1_5'UTR|ROR2_ENST00000550066.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	140	Ig-like C2-type.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GTCTTCATCCCGTTGGTGGCC	0.557000													33	19					0	0	1	0	0
GRIP1	23426	broad.mit.edu	37	12	66859151	66859151	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:66859151G>A	ENST00000359742.4	-	8	1016	c.776C>T	c.(775-777)cCt>cTt	p.P259L	GRIP1_ENST00000286445.7_Missense_Mutation_p.P259L|GRIP1_ENST00000398016.3_Missense_Mutation_p.P259L			Q9Y3R0	GRIP1_HUMAN	glutamate receptor interacting protein 1	259	PDZ 3.				androgen receptor signaling pathway|intracellular signal transduction|positive regulation of transcription, DNA-dependent|synaptic transmission	cell junction|cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|postsynaptic membrane	androgen receptor binding|beta-catenin binding|protein C-terminus binding|receptor signaling complex scaffold activity|transcription coactivator activity			NS(3)|breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(19)|ovary(2)|prostate(2)|skin(1)	50			GBM - Glioblastoma multiforme(2;0.00069)	GBM - Glioblastoma multiforme(28;0.0933)		GCTGGCACCAGGAGTTTTGGC	0.413000													32	23					0	0	1	0	0
TPTE2	93492	broad.mit.edu	37	13	20049728	20049728	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:20049728G>A	ENST00000400230.2	-	5	259	c.215C>T	c.(214-216)tCa>tTa	p.S72L	TPTE2_ENST00000457266.2_Intron|TPTE2_ENST00000382977.4_Missense_Mutation_p.S72L|TPTE2_ENST00000382975.4_Missense_Mutation_p.S72L|TPTE2_ENST00000255310.6_Intron|TPTE2_ENST00000382978.1_Missense_Mutation_p.S72L|TPTE2_ENST00000400103.2_Intron|TPTE2_ENST00000390680.2_Intron			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	72						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.S72*(1)		NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		TGCAAAGGATGATACAATTGA	0.338000													9	24					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151837862	151837862	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:151837862C>T	ENST00000535741.1	-	6	1147	c.674G>A	c.(673-675)tGg>tAg	p.W225*	LRBA_ENST00000510413.1_Nonsense_Mutation_p.W225*|LRBA_ENST00000357115.3_Nonsense_Mutation_p.W225*|LRBA_ENST00000507224.1_Nonsense_Mutation_p.W225*			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	225						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					CTGGTATGGCCATTTGGCTAT	0.318000													20	10					0	0	1	0	0
CDH8	1006	broad.mit.edu	37	16	61935302	61935302	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:61935302G>A	ENST00000577390.1	-	3	1282	c.328C>T	c.(328-330)Caa>Taa	p.Q110*	CDH8_ENST00000584337.1_Nonsense_Mutation_p.Q110*|CDH8_ENST00000299345.6_Nonsense_Mutation_p.Q110*|CDH8_ENST00000577730.1_Nonsense_Mutation_p.Q110*	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	110	Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		TCATTTATTTGAAATATGGTC	0.418000													24	26					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15733004	15733004	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:15733004G>A	ENST00000281171.4	+	21	3282	c.2952G>A	c.(2950-2952)atG>atA	p.M984I	PTPRO_ENST00000348962.2_Missense_Mutation_p.M956I|PTPRO_ENST00000445537.2_Missense_Mutation_p.M173I|PTPRO_ENST00000544244.1_Missense_Mutation_p.M145I|PTPRO_ENST00000442921.2_Missense_Mutation_p.M173I|PTPRO_ENST00000542557.1_Missense_Mutation_p.M145I	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	984	Tyrosine-protein phosphatase.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				TAGTCTCCATGAATGAAGAGG	0.363000													13	23					0	0	1	0	0
PLA2G6	8398	broad.mit.edu	37	22	38541473	38541473	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:38541473C>T	ENST00000332509.3	-	3	580	c.397G>A	c.(397-399)Gag>Aag	p.E133K	PLA2G6_ENST00000335539.3_Missense_Mutation_p.E133K|PLA2G6_ENST00000402064.1_Missense_Mutation_p.E133K	NM_003560.2	NP_003551.2	O60733	PA2G6_HUMAN	phospholipase A2, group VI (cytosolic, calcium-independent)	133					cardiolipin biosynthetic process|cell death|lipid catabolic process	centrosome|membrane				breast(2)|endometrium(6)|kidney(1)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	24	Melanoma(58;0.045)				Quinacrine(DB01103)	TGGAAGCACTCGCGGATCCCT	0.607000													12	3					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35644928	35644928	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:35644928C>T	ENST00000400445.3	+	10	2044	c.1510C>T	c.(1510-1512)Cca>Tca	p.P504S	NBEA_ENST00000379939.2_Missense_Mutation_p.P504S|NBEA_ENST00000540320.1_Missense_Mutation_p.P504S|NBEA_ENST00000310336.4_Missense_Mutation_p.P504S	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	504						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		AGTGCTTTTTCCACTTTTTGC	0.343000													57	43					0	0	1	0	0
USP19	10869	broad.mit.edu	37	3	49155168	49155168	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:49155168G>A	ENST00000453664.1	-	4	712	c.394C>T	c.(394-396)Cgt>Tgt	p.R132C	USP19_ENST00000398888.2_Missense_Mutation_p.R132C|USP19_ENST00000417901.1_Missense_Mutation_p.R132C|USP19_ENST00000434032.2_Missense_Mutation_p.R132C|USP19_ENST00000398892.3_Missense_Mutation_p.R70C|USP19_ENST00000398896.1_5'UTR|USP19_ENST00000488993.1_5'UTR|USP19_ENST00000398898.2_Missense_Mutation_p.R70C	NM_001199161.1|NM_001199162.1	NP_001186090.1|NP_001186091.1	O94966	UBP19_HUMAN	ubiquitin specific peptidase 19	132	CS 1.				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			NS(1)|breast(3)|endometrium(5)|kidney(2)|large_intestine(10)|lung(5)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	38				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		ACTCCCACACGAAGCTTGACA	0.532000													43	44					0	0	1	0	0
CCDC77	84318	broad.mit.edu	37	12	549873	549873	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:549873C>T	ENST00000239830.4	+	11	1311	c.1132C>T	c.(1132-1134)Cgt>Tgt	p.R378C	CCDC77_ENST00000540180.1_Missense_Mutation_p.R346C|CCDC77_ENST00000412006.2_Missense_Mutation_p.R346C|CCDC77_ENST00000422000.1_Missense_Mutation_p.R346C	NM_032358.3	NP_115734.1	Q9BR77	CCD77_HUMAN	coiled-coil domain containing 77	378						centrosome				cervix(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(10;0.0149)|all_epithelial(11;0.035)|all_lung(10;0.111)|Ovarian(42;0.142)|Lung NSC(10;0.156)		OV - Ovarian serous cystadenocarcinoma(31;0.00123)|BRCA - Breast invasive adenocarcinoma(9;0.033)			TGCCCGAATTCGTGAGGAAGA	0.433000													11	40					0	0	1	0	0
ST18	9705	broad.mit.edu	37	8	53084992	53084992	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:53084992C>T	ENST00000276480.7	-	10	1112	c.429G>A	c.(427-429)caG>caA	p.Q143Q		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	143						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				CACTTACAGTCTGAACAGATA	0.383000													26	46					0	0	1	0	0
SPECC1L	23384	broad.mit.edu	37	22	24730521	24730521	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:24730521C>T	ENST00000314328.9	+	9	2825	c.2540C>T	c.(2539-2541)tCc>tTc	p.S847F	SPECC1L_ENST00000437398.1_Missense_Mutation_p.S847F|KB-1896H10.1_ENST00000358654.2_Missense_Mutation_p.S847F|SPECC1L_ENST00000541492.1_Missense_Mutation_p.S847F	NM_001254733.1|NM_015330.3	NP_001241662.1|NP_056145.3	Q69YQ0	CYTSA_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1-like	847					cell cycle|cell division					breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(3)|stomach(2)|urinary_tract(1)	27						CTCATCAAGTCCTTTGACAGT	0.443000													58	61					0	0	1	0	0
RHOT2	89941	broad.mit.edu	37	16	720770	720770	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:720770C>T	ENST00000315082.4	+	9	750	c.636C>T	c.(634-636)ttC>ttT	p.F212F	RHOT2_ENST00000569943.2_Intron	NM_138769.2	NP_620124.1	Q8IXI1	MIRO2_HUMAN	ras homolog family member T2	212	EF-hand 1.				apoptosis|cellular homeostasis|mitochondrion transport along microtubule|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|integral to mitochondrial outer membrane|plasma membrane	calcium ion binding|GTP binding|GTPase activity|protein binding			endometrium(2)|kidney(3)|lung(4)|ovary(1)|pancreas(2)|prostate(1)	13		Hepatocellular(780;0.0218)				TCAACGCTTTCCAGGTGTGCC	0.662000													30	47					0	0	1	0	0
LRTOMT	220074	broad.mit.edu	37	11	71804597	71804597	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:71804597G>A	ENST00000324866.7	+	4	304	c.138G>A	c.(136-138)tcG>tcA	p.S46S	LRTOMT_ENST00000439209.1_Silent_p.S46S|LRTOMT_ENST00000307198.7_5'UTR|LRTOMT_ENST00000419228.1_5'UTR|LRTOMT_ENST00000447974.1_Silent_p.S46S|LRTOMT_ENST00000536917.1_Silent_p.S46S|LRTOMT_ENST00000539587.1_Intron|LRTOMT_ENST00000541614.1_Silent_p.S46S|LRTOMT_ENST00000539271.1_5'UTR|LRTOMT_ENST00000423494.2_Silent_p.S28S|LRTOMT_ENST00000435085.1_5'UTR|LRTOMT_ENST00000538478.1_Silent_p.S46S|LRTOMT_ENST00000289488.2_Silent_p.S46S|LAMTOR1_ENST00000545249.1_Intron	NM_001271471.2	NP_001258400.1	Q96E66	LRC51_HUMAN	leucine rich transmembrane and O-methyltransferase domain containing	46						cytoplasm				large_intestine(2)|lung(1)|ovary(1)	4						GTTCAAAGTCGGGGAAATCAC	0.488000													20	24					0	0	1	0	0
CLCN7	1186	broad.mit.edu	37	16	1507320	1507320	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:1507320A>G	ENST00000382745.4	-	9	1362	c.757T>C	c.(757-759)Tca>Cca	p.S253P	CLCN7_ENST00000262318.8_Missense_Mutation_p.S229P|CLCN7_ENST00000448525.1_Missense_Mutation_p.S229P	NM_001287.5	NP_001278.1	P51798	CLCN7_HUMAN	chloride channel, voltage-sensitive 7	253						integral to membrane|lysosomal membrane	antiporter activity|ATP binding|voltage-gated chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(3)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|skin(2)	24		Hepatocellular(780;0.0893)				ACTGAACCTGAGTGGATCATC	0.567000													37	37					0	0	1	0	0
LOC146880	146880	broad.mit.edu	37	17	62750764	62750764	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:62750764G>A	ENST00000400873.3	-	0	1849					NR_026899.1																						TGGCTCTTAGGGCAGGAGTCT	0.448000													38	64					0	0	1	0	0
NES	10763	broad.mit.edu	37	1	156640463	156640463	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:156640463C>T	ENST00000368223.3	-	4	3649	c.3517G>A	c.(3517-3519)Gag>Aag	p.E1173K		NM_006617.1	NP_006608.1	P48681	NEST_HUMAN	nestin	1173	Tail.				brain development|embryonic camera-type eye development|G2/M transition of mitotic cell cycle|negative regulation of apoptosis|positive regulation of intermediate filament depolymerization|positive regulation of neural precursor cell proliferation|stem cell proliferation	cytoplasm|intermediate filament	intermediate filament binding|structural molecule activity			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(30)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(4)	64	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TCTGACTCCTCCCTACCCTCC	0.647000													19	125					0	0	1	0	0
JARID2	3720	broad.mit.edu	37	6	15374358	15374358	+	Translation_Start_Site	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:15374358A>T	ENST00000397311.3	+	0	64				JARID2_ENST00000341776.2_Missense_Mutation_p.D19V	NM_001267040.1	NP_001253969.1	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2						central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(2)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	59	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				GATGACAGTGATGGGATTCCG	0.398000													26	148					0	0	1	0	0
PMS2	5395	broad.mit.edu	37	7	6037023	6037023	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:6037023G>A	ENST00000265849.7	-	7	842	c.737C>T	c.(736-738)cCc>cTc	p.P246L	PMS2_ENST00000406569.3_Missense_Mutation_p.P246L|PMS2_ENST00000441476.2_Missense_Mutation_p.P140L|PMS2_ENST00000382321.4_Missense_Mutation_p.P246L|PMS2_ENST00000469652.1_Intron	NM_000535.5	NP_000526.1	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	246					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(11)|lung(13)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		GTCACTAGGGGGCAGCTGAAC	0.378000			"""Mis, N, F"""			"""colorectal, endometrial, ovarian, medulloblastoma, glioma"""		Direct reversal of damage;Mismatch excision repair (MMR)	Turcot syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				4	20					0	0	1	0	0
RSPO2	340419	broad.mit.edu	37	8	109001376	109001376	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:109001376C>T	ENST00000276659.5	-	3	811	c.191G>A	c.(190-192)cGa>cAa	p.R64Q	RSPO2_ENST00000517781.1_Intron|RSPO2_ENST00000517939.1_5'UTR|RSPO2_ENST00000378439.2_Intron	NM_178565.4	NP_848660.3	Q6UXX9	RSPO2_HUMAN	R-spondin 2	64					Wnt receptor signaling pathway	extracellular region	heparin binding		EIF3E/RSPO2(6)	haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(3)	28			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			CCCTTCTCTTCGAAGGAAGAA	0.478000													27	40					0	0	1	0	0
OR52R1	119695	broad.mit.edu	37	11	4825489	4825489	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:4825489G>A	ENST00000380382.1	-	1	358	c.359C>T	c.(358-360)gCt>gTt	p.A120V	MMP26_ENST00000477339.1_Intron|OR52R1_ENST00000356069.2_Missense_Mutation_p.A41V|MMP26_ENST00000380390.1_Intron			Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R, member 1	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|prostate(1)|skin(3)	29		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TCCAACAACAGCCACAGCATA	0.512000													13	21					0	0	1	0	0
ACSM4	341392	broad.mit.edu	37	12	7470723	7470723	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:7470723G>A	ENST00000399422.4	+	5	914	c.866G>A	c.(865-867)gGa>gAa	p.G289E		NM_001080454.1	NP_001073923.1	P0C7M7	ACSM4_HUMAN	acyl-CoA synthetase medium-chain family member 4	289					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			endometrium(6)|kidney(1)|lung(14)	21						TGGCTGTGTGGAGCCTGTGTT	0.473000													10	44					0	0	1	0	0
DENND1C	79958	broad.mit.edu	37	19	6468605	6468605	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:6468605C>T	ENST00000381480.2	-	21	1679	c.1567G>A	c.(1567-1569)Gag>Aag	p.E523K	DENND1C_ENST00000543576.1_Missense_Mutation_p.E479K	NM_024898.2	NP_079174.2	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	523						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(3)|large_intestine(1)|lung(3)	10						CCTGGGGGCTCGGAAGTTCCC	0.632000													4	2					0	0	1	0	0
ZNF594	84622	broad.mit.edu	37	17	5087258	5087258	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:5087258G>A	ENST00000399604.4	-	1	434	c.294C>T	c.(292-294)tcC>tcT	p.S98S	ZNF594_ENST00000575779.1_Silent_p.S98S			Q96JF6	ZN594_HUMAN	zinc finger protein 594	98					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						CATATCTATGGGAGCTTTCTC	0.373000													26	7					0	0	1	0	0
NEB	4703	broad.mit.edu	37	2	152432773	152432773	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:152432773G>A	ENST00000397345.3	-	106	17002	c.16800C>T	c.(16798-16800)atC>atT	p.I5600I	NEB_ENST00000603639.1_Silent_p.I5600I|NEB_ENST00000604864.1_Silent_p.I5600I|NEB_ENST00000409198.1_Silent_p.I3899I|NEB_ENST00000172853.10_Silent_p.I3899I|NEB_ENST00000427231.2_Silent_p.I5600I	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	5611					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		TGTCACAAAAGATATTCTGGG	0.478000													29	45					0	0	1	0	0
MROH9	80133	broad.mit.edu	37	1	170961317	170961317	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:170961317G>A	ENST00000367759.4	+	12	1195	c.1041G>A	c.(1039-1041)caG>caA	p.Q347Q	MROH9_ENST00000367758.3_Silent_p.Q347Q	NM_001163629.1	NP_001157101.1			maestro heat-like repeat family member 9																		CTCTGATACAGATGTGGAAGG	0.478000													25	9					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36047937	36047937	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:36047937C>T	ENST00000262623.3	-	12	1775	c.1747G>A	c.(1747-1749)Gac>Aac	p.D583N		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	583					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding	p.D583N(1)		breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GCCTCTACGTCGAAGGCATAG	0.582000													25	54					0	0	1	0	0
IBA57	200205	broad.mit.edu	37	1	228353814	228353814	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:228353814C>T	ENST00000366711.3	+	1	299	c.297C>T	c.(295-297)ttC>ttT	p.F99F		NM_001010867.2	NP_001010867.1	Q5T440	CAF17_HUMAN	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)	99					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|prostate(1)	11						ACGCCCACTTCCTGAACGTGC	0.721000													4	1					0	0	1	0	0
EPB41L2	2037	broad.mit.edu	37	6	131216181	131216181	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:131216181G>A	ENST00000337057.3	-	9	1496	c.1315C>T	c.(1315-1317)Cgt>Tgt	p.R439C	EPB41L2_ENST00000525193.1_Missense_Mutation_p.R439C|EPB41L2_ENST00000527659.1_Missense_Mutation_p.R439C|EPB41L2_ENST00000392427.3_Missense_Mutation_p.R439C|EPB41L2_ENST00000529208.1_Missense_Mutation_p.R439C|EPB41L2_ENST00000368128.2_Missense_Mutation_p.R439C|EPB41L2_ENST00000528282.1_Missense_Mutation_p.R439C|EPB41L2_ENST00000445890.2_Missense_Mutation_p.R439C|EPB41L2_ENST00000527411.1_Missense_Mutation_p.R439C|EPB41L2_ENST00000525271.1_Missense_Mutation_p.R439C|EPB41L2_ENST00000530481.1_Missense_Mutation_p.R439C	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	439	FERM.				cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CAAGCAAAACGATTGATTCGC	0.413000													24	56					0	0	1	0	0
PCNXL2	80003	broad.mit.edu	37	1	233270915	233270915	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:233270915G>A	ENST00000258229.8	-	21	3915	c.3681C>T	c.(3679-3681)atC>atT	p.I1227I	PCNXL2_ENST00000488780.2_Silent_p.I360I|PCNXL2_ENST00000520463.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	1227						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				TGCCAGCAATGATCATCAGAA	0.413000													23	6					0	0	1	0	0
FAM187B	148109	broad.mit.edu	37	19	35719060	35719060	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:35719060G>A	ENST00000324675.3	-	1	572	c.524C>T	c.(523-525)gCc>gTc	p.A175V		NM_152481.1	NP_689694.1	Q17R55	F187B_HUMAN	family with sequence similarity 187, member B	175						integral to membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(2)	9						GCAGGGCATGGCTTCCTCCAG	0.622000													23	68					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122078506	122078506	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:122078506C>T	ENST00000334010.7	-	16	2789	c.2368G>A	c.(2368-2370)Gat>Aat	p.D790N	RP5-1101C3.1_ENST00000592542.1_RNA|CADPS2_ENST00000412584.2_Missense_Mutation_p.D786N|CADPS2_ENST00000313070.7_Missense_Mutation_p.D786N|CADPS2_ENST00000449022.2_Missense_Mutation_p.D789N	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	789	Interaction with DRD2.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						GTGGCAATATCTTTCATTAAA	0.423000													11	10					0	0	1	0	0
LELP1	149018	broad.mit.edu	37	1	153177379	153177379	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:153177379C>T	ENST00000368747.1	+	2	306	c.196C>T	c.(196-198)Cct>Tct	p.P66S		NM_001010857.1	NP_001010857.1	Q5T871	LELP1_HUMAN	late cornified envelope-like proline-rich 1	66	Cys/Pro-rich.									NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(9)|ovary(1)|pancreas(1)|prostate(1)	19	all_lung(78;3.51e-31)|Lung NSC(65;1.34e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			CTCGCAGTCTCCTTCATCCTG	0.607000													74	35					0	0	1	0	0
OR8K1	390157	broad.mit.edu	37	11	56114245	56114245	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:56114245T>C	ENST00000279783.2	+	1	825	c.731T>C	c.(730-732)tTc>tCc	p.F244S		NM_001002907.1	NP_001002907.1	Q8NGG5	OR8K1_HUMAN	olfactory receptor, family 8, subfamily K, member 1	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(8)|liver(2)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	33	Esophageal squamous(21;0.00448)					TACAAAGCCTTCTCCACCTGT	0.403000										HNSCC(65;0.19)			6	44					0	0	1	0	0
CNOT7	29883	broad.mit.edu	37	8	17102580	17102580	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:17102580G>A	ENST00000361272.4	-	2	380	c.82C>T	c.(82-84)Cgt>Tgt	p.R28C	CNOT7_ENST00000523917.1_Missense_Mutation_p.R28C|CNOT7_ENST00000518885.1_5'UTR	NM_013354.5	NP_037486.2	Q9UIV1	CNOT7_HUMAN	CCR4-NOT transcription complex, subunit 7	28					carbohydrate metabolic process|nuclear-transcribed mRNA poly(A) tail shortening	CCR4-NOT complex|cytoplasmic mRNA processing body|cytosol	nucleic acid binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity	p.R28C(1)		central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)	11				Colorectal(111;0.0523)|COAD - Colon adenocarcinoma(73;0.209)		ATAACTTGACGAATTTTCTTC	0.388000													10	31					0	0	1	0	0
SLC5A7	60482	broad.mit.edu	37	2	108627177	108627177	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:108627177G>A	ENST00000264047.2	+	9	1879	c.1603G>A	c.(1603-1605)Gaa>Aaa	p.E535K	SLC5A7_ENST00000409059.1_Missense_Mutation_p.E535K|SLC5A7_ENST00000540517.1_Missense_Mutation_p.E430K	NM_021815.2	NP_068587.1	Q9GZV3	SC5A7_HUMAN	solute carrier family 5 (sodium/choline cotransporter), member 7	535					acetylcholine biosynthetic process|neurotransmitter secretion	integral to membrane|plasma membrane	choline:sodium symporter activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(23)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	49					Choline(DB00122)	TGTCAAAAATGAAAATATTAA	0.373000													8	10					0	0	1	0	0
PENK	5179	broad.mit.edu	37	8	57354137	57354137	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:57354137G>A	ENST00000314922.3	-	2	574	c.498C>T	c.(496-498)aaC>aaT	p.N166N	PENK_ENST00000523274.1_5'UTR|PENK_ENST00000451791.2_Silent_p.N166N	NM_006211.3	NP_006202.1	P01210	PENK_HUMAN	proenkephalin	166					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|liver(1)|lung(5)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	21		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			TACGCTCTCGGTTGTCCCCTG	0.537000													36	85					0	0	1	0	0
ZNF396	252884	broad.mit.edu	37	18	32949320	32949320	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:32949320G>C	ENST00000306346.1	-	4	998	c.867C>G	c.(865-867)agC>agG	p.S289R	ZNF396_ENST00000589332.1_Missense_Mutation_p.S289R	NM_145756.2	NP_665699.1	Q96N95	ZN396_HUMAN	zinc finger protein 396	289					viral reproduction	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|pancreas(1)	7						TTGCGCTTCGGCTGAATGCCT	0.453000													22	36					0	0	1	0	0
KIAA1524	57650	broad.mit.edu	37	3	108295125	108295125	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:108295125G>A	ENST00000295746.8	-	8	963	c.887C>T	c.(886-888)tCt>tTt	p.S296F	KIAA1524_ENST00000487834.1_5'UTR|KIAA1524_ENST00000491772.1_Missense_Mutation_p.S137F	NM_020890.2	NP_065941.2	Q8TCG1	CIP2A_HUMAN	KIAA1524	296						cytoplasm|integral to membrane	protein binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(21)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TACCTTTGAAGAGGAATCAGG	0.294000													25	42					0	0	1	0	0
KBTBD11	9920	broad.mit.edu	37	8	1950698	1950698	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:1950698C>T	ENST00000320248.3	+	2	2306	c.1340C>T	c.(1339-1341)gCc>gTc	p.A447V		NM_014867.2	NP_055682.1	O94819	KBTBB_HUMAN	kelch repeat and BTB (POZ) domain containing 11	447										lung(1)|pancreas(1)	2		Ovarian(12;0.0563)|Colorectal(14;0.0815)|Hepatocellular(245;0.0831)		BRCA - Breast invasive adenocarcinoma(11;7.72e-05)|READ - Rectum adenocarcinoma(644;0.0929)|COAD - Colon adenocarcinoma(149;0.134)		ggcgccTTCGCCGTGGCGCAT	0.736000													3	7					0	0	1	0	0
HLA-DQA2	3118	broad.mit.edu	37	6	32714114	32714114	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:32714114C>T	ENST00000374940.3	+	4	813	c.711C>T	c.(709-711)gtC>gtT	p.V237V		NM_020056.4	NP_064440.1	P01906	DQA2_HUMAN	major histocompatibility complex, class II, DQ alpha 2	237					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|interferon-gamma-mediated signaling pathway|T cell costimulation|T cell receptor signaling pathway	endoplasmic reticulum membrane|endosome membrane|Golgi apparatus|integral to plasma membrane|lysosomal membrane|MHC class II protein complex	MHC class II receptor activity			endometrium(2)|large_intestine(3)|lung(7)|skin(1)	13					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGGGCACTGTCTTCATCATCC	0.532000													41	90					0	0	1	0	0
SATB1	6304	broad.mit.edu	37	3	18438769	18438769	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:18438769G>A	ENST00000338745.6	-	6	2387	c.653C>T	c.(652-654)tCc>tTc	p.S218F	SATB1_ENST00000417717.2_Missense_Mutation_p.S218F|TBC1D5_ENST00000414318.2_Intron|SATB1_ENST00000475083.1_5'UTR|SATB1_ENST00000454909.2_Missense_Mutation_p.S218F	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	218					cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						GTTCACAATGGAAGAAATCAT	0.373000													35	45					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9002184	9002184	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:9002184G>A	ENST00000397910.4	-	52	40523	c.40320C>T	c.(40318-40320)ttC>ttT	p.F13440F	MUC16_ENST00000380951.5_Silent_p.F81F	NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	13442					cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.F13440F(1)|p.F125F(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTGATGGGTGAAACCTGCAT	0.507000													6	15					0	0	1	0	0
KRT6C	286887	broad.mit.edu	37	12	52864331	52864331	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:52864331C>T	ENST00000252250.6	-	6	1208	c.1161G>A	c.(1159-1161)atG>atA	p.M387I		NM_173086.4	NP_775109.2	P48668	K2C6C_HUMAN	keratin 6C	387	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|prostate(2)|skin(2)	23				BRCA - Breast invasive adenocarcinoma(357;0.0828)		GCCTCTGGATCATGCGGTTGA	0.547000													28	49					0	0	1	0	0
CYYR1	116159	broad.mit.edu	37	21	27945291	27945291	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:27945291G>A	ENST00000435845.2	-	1	312	c.293C>T	c.(292-294)cCc>cTc	p.P98L	CYYR1_ENST00000400043.3_5'UTR|CYYR1_ENST00000299340.4_5'UTR			Q96J86	CYYR1_HUMAN	cysteine/tyrosine-rich 1	139						integral to membrane				large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	15						TGGAGCGAAGGGAGAGCCCGG	0.642000													21	28					0	0	1	0	0
DIDO1	11083	broad.mit.edu	37	20	61542877	61542877	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:61542877G>A	ENST00000266070.4	-	3	413	c.88C>T	c.(88-90)Cga>Tga	p.R30*	DIDO1_ENST00000354665.4_Nonsense_Mutation_p.R30*|DIDO1_ENST00000370368.1_Nonsense_Mutation_p.R30*|DIDO1_ENST00000395335.2_Nonsense_Mutation_p.R30*|DIDO1_ENST00000266071.5_Nonsense_Mutation_p.R30*|DIDO1_ENST00000395340.1_Nonsense_Mutation_p.R30*|DIDO1_ENST00000395343.1_Nonsense_Mutation_p.R30*|DIDO1_ENST00000370371.4_Nonsense_Mutation_p.R30*|DIDO1_ENST00000370366.1_Nonsense_Mutation_p.R30*	NM_033081.2	NP_149072.2	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1	30					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(6)|breast(5)|central_nervous_system(1)|cervix(3)|endometrium(6)|kidney(1)|large_intestine(17)|lung(39)|ovary(8)|prostate(3)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)	99	Breast(26;5.68e-08)					GTGGTCCTTCGAAAACCCCAT	0.617000													3	19					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41748903	41748903	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:41748903G>A	ENST00000301178.4	+	11	1618	c.1428G>A	c.(1426-1428)aaG>aaA	p.K476K	AXL_ENST00000593513.1_Silent_p.K208K|AXL_ENST00000359092.3_Silent_p.K467K	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	476						integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						ACCGGCGAAAGAAGGAGACCC	0.617000													19	48					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175372560	175372560	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:175372560G>A	ENST00000367674.1	-	4	1400	c.692C>T	c.(691-693)tCc>tTc	p.S231F	TNR_ENST00000263525.2_Missense_Mutation_p.S231F	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	231	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					CCGGAGTTCGGAACAGTCATC	0.637000													110	52					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26400815	26400815	+	Missense_Mutation	SNP	G	G	A	rs114090829	by1000genomes	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:26400815G>A	ENST00000335473.7	+	42	6714	c.6464G>A	c.(6463-6465)aGc>aAc	p.S2155N	MYO18B_ENST00000407587.2_Missense_Mutation_p.S2156N|MYO18B_ENST00000536101.1_Missense_Mutation_p.S2155N	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2155						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CGCATCCTCAGCCCCAGGTAA	0.517000													42	64					0	0	1	0	0
PTPN9	5780	broad.mit.edu	37	15	75801285	75801285	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:75801285G>A	ENST00000306726.2	-	6	1124	c.612C>T	c.(610-612)ctC>ctT	p.L204L		NM_002833.2	NP_002824.1	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type 9	204	CRAL-TRIO.					cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						CCTTCAGGAGGAGACTGATGA	0.473000													7	14					0	0	1	0	0
NHSL2	340527	broad.mit.edu	37	X	71359707	71359707	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:71359707C>T	ENST00000373677.1	+	2	2473	c.1211C>T	c.(1210-1212)tCa>tTa	p.S404L	NHSL2_ENST00000510661.1_Missense_Mutation_p.S539L|NHSL2_ENST00000535692.1_Missense_Mutation_p.S404L|NHSL2_ENST00000540800.1_Missense_Mutation_p.S770L			F5H593	F5H593_HUMAN	NHS-like 2	770										NS(1)|breast(3)|endometrium(4)|kidney(2)|large_intestine(10)|lung(7)|stomach(1)	28	Renal(35;0.156)					TCACGGCTATCATTTGACCTA	0.527000													23	1					0	0	1	0	0
LHCGR	3973	broad.mit.edu	37	2	48925816	48925816	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:48925816G>A	ENST00000294954.7	-	9	825	c.804C>T	c.(802-804)ctC>ctT	p.L268L	LHCGR_ENST00000344775.3_Intron|STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000405626.1_Silent_p.L268L|LHCGR_ENST00000403273.1_Silent_p.L268L|LHCGR_ENST00000401907.1_Silent_p.L268L	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	268					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	TGGCCTCCAGGAGATTGACAA	0.458000													22	22					0	0	1	0	0
ROR2	4920	broad.mit.edu	37	9	94519598	94519598	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:94519598C>T	ENST00000375708.3	-	3	617	c.419G>A	c.(418-420)gGg>gAg	p.G140E	ROR2_ENST00000375715.1_5'UTR|ROR2_ENST00000550066.1_5'UTR	NM_004560.3	NP_004551.2	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	140	Ig-like C2-type.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						GGTCTTCATCCCGTTGGTGGC	0.557000													33	18					0	0	1	0	0
GRM6	2916	broad.mit.edu	37	5	178418523	178418523	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:178418523C>T	ENST00000231188.5	-	3	937	c.759G>A	c.(757-759)agG>agA	p.R253R	GRM6_ENST00000517717.1_Silent_p.R253R	NM_000843.3	NP_000834.2	O15303	GRM6_HUMAN	glutamate receptor, metabotropic 6	253					detection of visible light|visual perception	integral to plasma membrane				NS(2)|breast(4)|endometrium(9)|large_intestine(12)|lung(21)|ovary(2)|pancreas(1)|prostate(3)|urinary_tract(1)	55	all_cancers(89;0.000828)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.0156)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.245)		GCTTTGGTTCCCTGGGAATCT	0.592000													91	119					0	0	1	0	0
SPICE1	152185	broad.mit.edu	37	3	113172416	113172416	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:113172416G>A	ENST00000295872.4	-	14	2298	c.2039C>T	c.(2038-2040)tCa>tTa	p.S680L		NM_144718.3	NP_653319.1	Q8N0Z3	SPICE_HUMAN	spindle and centriole associated protein 1	680					cell division|mitosis	centriole|spindle	protein binding			NS(1)|autonomic_ganglia(1)|breast(4)|endometrium(3)|large_intestine(9)|lung(10)|ovary(2)|skin(2)|urinary_tract(1)	33						CTTGATAGCTGAATTCTGCAA	0.428000													28	65					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9057400	9057400	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:9057400C>T	ENST00000397910.4	-	3	30249	c.30046G>A	c.(30046-30048)Gaa>Aaa	p.E10016K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10018	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTAGTTTTTTCCACAAAGAGA	0.438000													24	36					0	0	1	0	0
TSLP	85480	broad.mit.edu	37	5	110411643	110411643	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:110411643G>A	ENST00000420978.2	+	5	1773		c.e5-1		TSLP_ENST00000344895.3_Splice_Site|TSLP_ENST00000379706.4_Splice_Site			Q969D9	TSLP_HUMAN	thymic stromal lymphopoietin							extracellular space	cytokine activity			breast(1)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|stomach(1)	11		all_cancers(142;2.72e-05)|all_epithelial(76;4.39e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0417)|Ovarian(225;0.0443)|Colorectal(57;0.0464)|all_lung(232;0.0507)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.24e-08)|Epithelial(69;1.54e-07)|all cancers(49;1.73e-05)|COAD - Colon adenocarcinoma(37;0.109)		ATATTCTGCAGATAAATGCTA	0.363000													17	22					0	0	1	0	0
APBB2	323	broad.mit.edu	37	4	41016113	41016113	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:41016113G>A	ENST00000295974.8	-	6	951	c.322C>T	c.(322-324)Cgt>Tgt	p.R108C	APBB2_ENST00000508593.1_Missense_Mutation_p.R108C|APBB2_ENST00000513140.1_Missense_Mutation_p.R108C|APBB2_ENST00000506352.1_Missense_Mutation_p.R108C	NM_001166050.1|NM_004307.1	NP_001159522.1|NP_004298.1	Q92870	APBB2_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 2	108					cell cycle arrest|intracellular signal transduction|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|regulation of transcription, DNA-dependent	growth cone|lamellipodium|membrane|nucleus|synapse	beta-amyloid binding|transcription factor binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(5)|lung(16)|ovary(3)|skin(2)|urinary_tract(1)	34						GCAGCCTTACGGAGCTGGTTC	0.562000													19	53					0	0	1	0	0
DDI2	84301	broad.mit.edu	37	1	15978205	15978205	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:15978205C>T	ENST00000480945.1	+	8	1169	c.998C>T	c.(997-999)tCc>tTc	p.S333F		NM_032341.4	NP_115717.3	Q5TDH0	DDI2_HUMAN	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	333					proteolysis		aspartic-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(7)|pancreas(1)|prostate(1)|stomach(1)	17		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00327)|Lung NSC(340;0.00566)|all_lung(284;0.00831)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.03e-07)|COAD - Colon adenocarcinoma(227;4.48e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00773)|READ - Rectum adenocarcinoma(331;0.0656)		TCCAAGTGTTCCATCGACCTG	0.443000													10	43					0	0	1	0	0
TENM2	57451	broad.mit.edu	37	5	167645264	167645264	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:167645264C>T	ENST00000519204.1	+	22	4123	c.4005C>T	c.(4003-4005)tgC>tgT	p.C1335C	TENM2_ENST00000545108.1_Silent_p.C1455C|TENM2_ENST00000518659.1_Silent_p.C1456C|TENM2_ENST00000403607.2_Silent_p.C1280C|TENM2_ENST00000520394.1_Silent_p.C1217C					teneurin transmembrane protein 2																		CCATGCACTGCCAAGTTCCTG	0.507000													80	150					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18703394	18703394	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:18703394G>A	ENST00000251296.1	+	8	1585	c.1202G>A	c.(1201-1203)cGg>cAg	p.R401Q	IGSF21_ENST00000473951.1_3'UTR	NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	401	Ig-like 2.					extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		GTGCTGGAGCGGGTTCCCGCC	0.652000													12	44					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54784964	54784964	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:54784964C>T	ENST00000218436.6	-	8	1572	c.1543G>A	c.(1543-1545)Gaa>Aaa	p.E515K		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	515					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										ATGCCCAGTTCCTGTTTGCCT	0.622000													17	6					0	0	1	0	0
LGSN	51557	broad.mit.edu	37	6	63990398	63990398	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:63990398G>A	ENST00000370657.4	-	4	1091	c.1058C>T	c.(1057-1059)gCt>gTt	p.A353V	LGSN_ENST00000370658.5_3'UTR			Q5TDP6	LGSN_HUMAN	lengsin, lens protein with glutamine synthetase domain	353					glutamine biosynthetic process		glutamate-ammonia ligase activity			NS(1)|endometrium(2)|large_intestine(5)|lung(16)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	34					L-Glutamic Acid(DB00142)	GCTGAGCGCAGCAGAGTGCTT	0.502000													38	73					0	0	1	0	0
NUP210L	91181	broad.mit.edu	37	1	154090291	154090291	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:154090291C>T	ENST00000368559.3	-	12	1601	c.1530G>A	c.(1528-1530)acG>acA	p.T510T	NUP210L_ENST00000271854.3_Silent_p.T510T	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	510						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			CCACTCCTTTCGTGGTTACTA	0.433000													21	73					0	0	1	0	0
DOCK6	57572	broad.mit.edu	37	19	11362811	11362811	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:11362811G>A	ENST00000294618.7	-	5	502	c.491C>T	c.(490-492)tCc>tTc	p.S164F		NM_020812.3	NP_065863.2	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	164					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(1)|endometrium(11)|large_intestine(8)|liver(2)|lung(9)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	39						CTCAGGGCCGGACCTCTCGTC	0.617000													5	5					0	0	1	0	0
CHRM3	1131	broad.mit.edu	37	1	240072452	240072452	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:240072452G>A	ENST00000255380.4	+	5	2480	c.1701G>A	c.(1699-1701)aaG>aaA	p.K567K		NM_000740.2	NP_000731.1	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	567					cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(3)|endometrium(5)|kidney(2)|large_intestine(4)|lung(19)|ovary(4)|prostate(1)|skin(12)|upper_aerodigestive_tract(1)	51	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	ACAAAAAAAAGAGGCGCAAGC	0.493000													29	54					0	0	1	0	0
CCDC136	64753	broad.mit.edu	37	7	128445926	128445926	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:128445926C>T	ENST00000297788.4	+	7	1427	c.1060C>T	c.(1060-1062)Cgg>Tgg	p.R354W	CCDC136_ENST00000378685.4_Missense_Mutation_p.R392W|CCDC136_ENST00000464832.1_Missense_Mutation_p.R404W|CCDC136_ENST00000487361.1_Missense_Mutation_p.R354W	NM_022742.4	NP_073579.4	Q96JN2	CC136_HUMAN	coiled-coil domain containing 136	354						integral to membrane	protein binding	p.R354W(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)	24						TGAGGTGCTTCGGTTTCAGAC	0.607000													23	33					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21232835	21232835	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:21232835C>T	ENST00000233242.1	-	26	7032	c.6905G>A	c.(6904-6906)gGa>gAa	p.G2302E		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2302					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AATTGTAGTTCCCAATTGATC	0.328000													37	55					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9064338	9064338	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:9064338G>A	ENST00000397910.4	-	3	23311	c.23108C>T	c.(23107-23109)tCc>tTc	p.S7703F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	7705	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAATGTGGTGGAAACAGGATG	0.562000													20	44					0	0	1	0	0
UBE3B	89910	broad.mit.edu	37	12	109939175	109939175	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:109939175G>A	ENST00000342494.3	+	13	1713		c.e13-1		UBE3B_ENST00000280774.5_Splice_Site|UBE3B_ENST00000434735.2_Splice_Site	NM_130466.3	NP_569733.2	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			NS(1)|breast(3)|endometrium(6)|kidney(4)|large_intestine(7)|lung(20)|ovary(2)|urinary_tract(2)	45						CTCTCTCCTAGCCTTAACGAG	0.542000													91	130					0	0	1	0	0
CDH16	1014	broad.mit.edu	37	16	66946460	66946460	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:66946460C>T	ENST00000299752.4	-	11	1499	c.1306G>A	c.(1306-1308)Gaa>Aaa	p.E436K	CDH16_ENST00000394055.3_Missense_Mutation_p.E436K|CDH16_ENST00000568632.1_Missense_Mutation_p.E339K|CDH16_ENST00000565796.1_Missense_Mutation_p.E436K|CDH16_ENST00000570262.1_Missense_Mutation_p.E356K	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	436	Cadherin 4.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		ACTGCGACTTCGACTTCACAC	0.592000													33	36					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8486025	8486025	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:8486025G>T	ENST00000381196.4	-	25	3335	c.2792C>A	c.(2791-2793)aCt>aAt	p.T931N	PTPRD_ENST00000397617.3_Intron|PTPRD_ENST00000360074.4_Missense_Mutation_p.T918N|PTPRD_ENST00000397611.3_Intron|PTPRD_ENST00000355233.5_Intron|PTPRD_ENST00000397606.3_Intron|PTPRD_ENST00000358503.5_Missense_Mutation_p.T909N|PTPRD_ENST00000540109.1_Missense_Mutation_p.T931N|PTPRD_ENST00000356435.5_Missense_Mutation_p.T931N|PTPRD_ENST00000486161.1_Intron|PTPRD_ENST00000537002.1_Intron|PTPRD_ENST00000471274.1_5'UTR	NM_002839.3	NP_002830.1	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	931	Fibronectin type-III 7.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GGAGGTTGAAGTGGTGCCTTC	0.468000										TSP Lung(15;0.13)			17	20					3.45872e-05	3.47239e-05	1	1	0
ZNF536	9745	broad.mit.edu	37	19	31039446	31039446	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:31039446G>A	ENST00000355537.3	+	4	3067	c.2920G>A	c.(2920-2922)Gaa>Aaa	p.E974K		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	974					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					ATCTCAGTATGAACCCCTGGA	0.592000													60	85					0	0	1	0	0
SELV	348303	broad.mit.edu	37	19	40009430	40009430	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:40009430C>T	ENST00000423711.1	+	4	985	c.885C>T	c.(883-885)ctC>ctT	p.L295L	SELV_ENST00000335426.4_Silent_p.L295L			P59797	SELV_HUMAN		295					cell redox homeostasis		selenium binding			breast(1)|endometrium(1)|lung(3)|prostate(1)	6	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;8.61e-26)|all cancers(26;2.76e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			ATCACCTACTCTTTGTAAGTG	0.577000													17	35					0	0	1	0	0
MAST4	375449	broad.mit.edu	37	5	66350257	66350257	+	Silent	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:66350257T>C	ENST00000404260.3	+	5	1008	c.700T>C	c.(700-702)Tta>Cta	p.L234L	MAST4_ENST00000490016.2_Silent_p.L45L|MAST4_ENST00000405643.1_Silent_p.L52L|MAST4_ENST00000403625.2_Silent_p.L234L|MAST4_ENST00000261569.7_Silent_p.L40L|MAST4_ENST00000403666.1_Silent_p.L45L			O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase family member 4	234						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			breast(2)|central_nervous_system(1)|kidney(2)|lung(6)|ovary(2)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		CCGGAAAAGCTTAATAGGCAA	0.393000													4	7					0	0	1	0	0
RPS13	6207	broad.mit.edu	37	11	17096727	17096727	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:17096727G>A	ENST00000525634.1	-	5	484	c.339C>T	c.(337-339)ttC>ttT	p.F113F	RPS13_ENST00000526895.1_5'UTR|RPS13_ENST00000228140.2_Intron			P62277	RS13_HUMAN	ribosomal protein S13	113					endocrine pancreas development|negative regulation of RNA splicing|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|nucleolus	mRNA binding|protein binding|structural constituent of ribosome			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)	5						GAATCAGACGGAATTTAGCAT	0.363000													15	30					0	0	1	0	0
PRKD3	23683	broad.mit.edu	37	2	37502923	37502923	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:37502923G>A	ENST00000379066.1	-	10	2123	c.1361C>T	c.(1360-1362)tCa>tTa	p.S454L	PRKD3_ENST00000234179.2_Missense_Mutation_p.S454L			O94806	KPCD3_HUMAN	protein kinase D3	454	PH.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			breast(3)|central_nervous_system(2)|kidney(3)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33		all_hematologic(82;0.21)				ATAATACTTTGATCCAGATTC	0.264000													9	13					0	0	1	0	0
MYT1L	23040	broad.mit.edu	37	2	1926121	1926121	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:1926121G>A	ENST00000399161.2	-	10	2167	c.1420C>T	c.(1420-1422)Ccc>Tcc	p.P474S	MYT1L_ENST00000428368.2_Missense_Mutation_p.P474S	NM_015025.2	NP_055840.2	Q9UL68	MYT1L_HUMAN	myelin transcription factor 1-like	474					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(16)|lung(50)|ovary(5)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	97	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.037)|all_epithelial(98;0.241)		OV - Ovarian serous cystadenocarcinoma(76;0.169)|all cancers(51;0.244)		TCCTCCCCGGGAAGTTGTCTC	0.473000													36	37					0	0	1	0	0
MAPK6	5597	broad.mit.edu	37	15	52339121	52339121	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:52339121C>T	ENST00000261845.5	+	2	1271	c.464C>T	c.(463-465)cCa>cTa	p.P155L		NM_002748.3	NP_002739.1	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	155	Protein kinase.				cell cycle		ATP binding|MAP kinase activity			breast(3)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	20				all cancers(107;0.0028)		GATCTCAAACCAGCTAATCTT	0.438000													32	35					0	0	1	0	0
MAGEL2	54551	broad.mit.edu	37	15	23889856	23889856	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:23889856C>T	ENST00000532292.1	-	1	1319	c.1225G>A	c.(1225-1227)Gtg>Atg	p.V409M		NM_019066.4	NP_061939.3			MAGE-like 2											breast(1)|endometrium(1)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;1.84e-06)|Epithelial(43;1.2e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00177)		TGTGCCTCCACCTTGGAATTA	0.582000													17	13					0	0	1	0	0
OR51G1	79324	broad.mit.edu	37	11	4945190	4945190	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:4945190G>A	ENST00000321961.2	-	1	447	c.380C>T	c.(379-381)gCc>gTc	p.A127V	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001005237.1	NP_001005237.1	Q8NGK1	O51G1_HUMAN	olfactory receptor, family 51, subfamily G, member 1	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(3)|skin(4)|soft_tissue(1)	25		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.58e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0284)|LUSC - Lung squamous cell carcinoma(625;0.19)		GTTGCAGACGGCCACGTAGCG	0.517000													19	46					0	0	1	0	0
FAT3	120114	broad.mit.edu	37	11	92495274	92495274	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:92495274C>T	ENST00000298047.6	+	4	3939	c.3922C>T	c.(3922-3924)Cct>Tct	p.P1308S	FAT3_ENST00000409404.2_Missense_Mutation_p.P1308S|RP11-203F8.1_ENST00000529884.1_RNA|FAT3_ENST00000525166.1_Missense_Mutation_p.P1158S			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1308	Cadherin 12.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CTTTATTGACCCTAAAACTGG	0.448000										TCGA Ovarian(4;0.039)			32	48					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28272903	28272903	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:28272903C>T	ENST00000305242.5	-	6	780	c.688G>A	c.(688-690)Gaa>Aaa	p.E230K	ARMC4_ENST00000239715.3_Missense_Mutation_p.E87K	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	230							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						TTTGAAAATTCATAATCTGAA	0.388000													16	9					0	0	1	0	0
C2CD3	26005	broad.mit.edu	37	11	73759361	73759361	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:73759361G>A	ENST00000334126.7	-	28	5610	c.5384C>T	c.(5383-5385)tCc>tTc	p.S1795F	C2CD3_ENST00000313663.7_Missense_Mutation_p.S1795F			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	1795						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					GGCAGGGAAGGAAAAGGGACT	0.433000													8	18					0	0	1	0	0
MACF1	23499	broad.mit.edu	37	1	39854048	39854048	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:39854048C>T	ENST00000564288.1	+	58	16311	c.15534C>T	c.(15532-15534)gcC>gcT	p.A5178A	MACF1_ENST00000372915.3_Silent_p.A5183A|MACF1_ENST00000567887.1_Silent_p.A5215A|MACF1_ENST00000545844.1_Silent_p.A3116A|MACF1_ENST00000361689.2_Silent_p.A3116A|MACF1_ENST00000317713.7_Silent_p.A3116A|MACF1_ENST00000539005.1_Silent_p.A3095A|MACF1_ENST00000289893.4_Silent_p.A3618A			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	5183					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ACATAGAGGCCTCTGAAGCAG	0.473000													25	15					0	0	1	0	0
CES3	23491	broad.mit.edu	37	16	66997451	66997451	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:66997451G>A	ENST00000303334.4	+	3	416	c.345G>A	c.(343-345)caG>caA	p.Q115Q	CES3_ENST00000394037.1_Silent_p.Q115Q	NM_024922.5	NP_079198.2	Q6UWW8	EST3_HUMAN	carboxylesterase 3	115						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	24		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		ACGGAAAACAGCAGATCTTCT	0.607000													21	50					0	0	1	0	0
OSBP	5007	broad.mit.edu	37	11	59361107	59361107	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:59361107G>A	ENST00000263847.1	-	9	2127	c.1648C>T	c.(1648-1650)Cga>Tga	p.R550*		NM_002556.2	NP_002547.1	P22059	OSBP1_HUMAN	oxysterol binding protein	550					lipid transport	Golgi membrane	oxysterol binding			NS(2)|breast(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	26		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TATTTGCCTCGAAACTTGCTG	0.478000													37	33					0	0	1	0	0
CCNL2	81669	broad.mit.edu	37	1	1334431	1334431	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:1334431G>A	ENST00000400809.3	-	1	261	c.256C>T	c.(256-258)Cag>Tag	p.Q86*	CCNL2_ENST00000408918.4_Nonsense_Mutation_p.Q86*	NM_030937.4	NP_112199.2	Q96S94	CCNL2_HUMAN	cyclin L2	86	Cyclin-like 1.				regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(3)|ovary(2)|prostate(2)	13	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		CCGGCCGCCTGGATGAGCTCG	0.716000													27	5					0	0	1	0	0
ST3GAL5	8869	broad.mit.edu	37	2	86090553	86090553	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:86090553G>A	ENST00000377332.3	-	2	246	c.138C>T	c.(136-138)tcC>tcT	p.S46S	ST3GAL5_ENST00000525834.2_Silent_p.S46S|ST3GAL5_ENST00000393805.1_Silent_p.S18S|ST3GAL5_ENST00000484728.1_5'UTR|ST3GAL5_ENST00000393808.3_Silent_p.S23S	NM_003896.3	NP_003887.3	Q9UNP4	SIAT9_HUMAN	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	46					ganglioside biosynthetic process|protein glycosylation	integral to Golgi membrane|integral to plasma membrane	lactosylceramide alpha-2,3-sialyltransferase activity|neolactotetraosylceramide alpha-2,3-sialyltransferase activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	15						ACCATTGCAGGGAAGGCCTCG	0.512000													23	58					0	0	1	0	0
PCCA	5095	broad.mit.edu	37	13	101077939	101077939	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:101077939C>T	ENST00000376285.1	+	20	1837	c.1799C>T	c.(1798-1800)tCg>tTg	p.S600L	PCCA_ENST00000376279.3_Missense_Mutation_p.S600L|PCCA_ENST00000376286.4_Missense_Mutation_p.S574L	NM_000282.3	NP_000273.2	P05165	PCCA_HUMAN	propionyl CoA carboxylase, alpha polypeptide	600					fatty acid beta-oxidation	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|enzyme binding|metal ion binding|propionyl-CoA carboxylase activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|prostate(1)|skin(2)	26	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)				Biotin(DB00121)	AACCTGGCTTCGCCCTTATTG	0.478000													17	23					0	0	1	0	0
MYO7B	4648	broad.mit.edu	37	2	128389307	128389307	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:128389307A>T	ENST00000389524.4	+	37	5206	c.5153A>T	c.(5152-5154)cAg>cTg	p.Q1718L	MYO7B_ENST00000409816.2_Missense_Mutation_p.Q1717L|MYO7B_ENST00000428314.1_Missense_Mutation_p.Q1717L|MYO7B_ENST00000409090.1_Missense_Mutation_p.Q570L			Q6PIF6	MYO7B_HUMAN	myosin VIIB	1717	MyTH4 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			breast(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(46)|ovary(3)|pancreas(1)|prostate(3)|urinary_tract(1)	75	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		ATCCTGAAGCAGCTGACGCAC	0.687000													9	22					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69817217	69817217	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:69817217C>T	ENST00000251566.4	-	1	292	c.262G>A	c.(262-264)Gaa>Aaa	p.E88K		NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	88						integral to membrane	glucuronosyltransferase activity	p.E88K(1)		NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						ACAAATATTTCATTTTCTTCT	0.363000													30	23					0	0	1	0	0
UGT2B11	10720	broad.mit.edu	37	4	70079873	70079873	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:70079873G>A	ENST00000446444.1	-	1	576	c.568C>T	c.(568-570)Cct>Tct	p.P190S	RP11-704M14.1_ENST00000504301.1_RNA|RP11-704M14.1_ENST00000505646.1_RNA	NM_001073.1	NP_001064.1	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B11	190					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	42						TAGGAAGGAGGGAAAATCAGT	0.403000													55	37					0	0	1	0	0
PTCHD2	57540	broad.mit.edu	37	1	11589959	11589959	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:11589959C>T	ENST00000294484.6	+	15	3183	c.3045C>T	c.(3043-3045)ttC>ttT	p.F1015F	PTCHD2_ENST00000389575.3_Silent_p.F1015F	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	1015					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		TTGTGGTCTTCGGCATTATTG	0.647000													22	107					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25423785	25423785	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:25423785G>A	ENST00000441592.2	+	0	356																											GTGCACTTGAGCTCAAGCCCT	0.632000													21	60					0	0	1	0	0
SCARA3	51435	broad.mit.edu	37	8	27528639	27528639	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:27528639G>A	ENST00000301904.3	+	6	1612	c.1592G>A	c.(1591-1593)gGa>gAa	p.G531E	SCARA3_ENST00000337221.4_Intron	NM_016240.2	NP_057324.2	Q6AZY7	SCAR3_HUMAN	scavenger receptor class A, member 3	531					response to oxidative stress|UV protection	collagen|endoplasmic reticulum membrane|Golgi membrane|integral to membrane	scavenger receptor activity			breast(1)|large_intestine(3)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	9		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0219)|Colorectal(74;0.148)		TTTGGAACTGGAGGGCCGAGA	0.682000													4	10					0	0	1	0	0
SLC45A4	57210	broad.mit.edu	37	8	142226067	142226067	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:142226067G>A	ENST00000519067.1	-	6	1882	c.1579C>T	c.(1579-1581)Ctg>Ttg	p.L527L	SLC45A4_ENST00000433583.2_Silent_p.L520L|SLC45A4_ENST00000024061.3_Silent_p.L527L|SLC45A4_ENST00000517878.1_Silent_p.L578L			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	578					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TTCTGTAACAGGGCTGCAGAG	0.642000													4	21					0	0	1	0	0
ARNT2	9915	broad.mit.edu	37	15	80806740	80806740	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:80806740C>T	ENST00000533983.1	+	9	1177	c.838C>T	c.(838-840)Cca>Tca	p.P280S	ARNT2_ENST00000527771.1_Missense_Mutation_p.P280S|ARNT2_ENST00000303329.4_Missense_Mutation_p.P291S			Q9HBZ2	ARNT2_HUMAN	aryl-hydrocarbon receptor nuclear translocator 2	291					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity	p.P291T(1)		NS(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(16)|ovary(1)|pancreas(2)|prostate(2)|skin(1)	35			BRCA - Breast invasive adenocarcinoma(143;0.134)			GGCCTGGCCACCAGCAGGTAA	0.478000													58	50					0	0	1	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101795426	101795426	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:101795426G>A	ENST00000506729.1	-	5	1126	c.955C>T	c.(955-957)Ctt>Ttt	p.L319F	SLCO6A1_ENST00000513675.1_Intron|SLCO6A1_ENST00000379810.1_Intron|SLCO6A1_ENST00000389019.3_Missense_Mutation_p.L257F|SLCO6A1_ENST00000379807.3_Missense_Mutation_p.L319F|SLCO6A1_ENST00000514551.1_5'UTR			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	319						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		GCGGCAAAAAGAAAATTAATC	0.333000													20	21					0	0	1	0	0
KRT3	3850	broad.mit.edu	37	12	53189322	53189322	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:53189322C>T	ENST00000417996.2	-	1	579	c.505G>A	c.(505-507)Gga>Aga	p.G169R	KRT3_ENST00000309505.3_Missense_Mutation_p.G169R	NM_057088.2	NP_476429.2	P12035	K2C3_HUMAN	keratin 3	169	Gly-rich.|Head.				epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|skin(1)	23						TCCTGAATTCCCCCAGGAAAG	0.597000													17	12					0	0	1	0	0
RCN2	5955	broad.mit.edu	37	15	77224705	77224705	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:77224705G>A	ENST00000394885.3	+	2	371	c.148G>A	c.(148-150)Gat>Aat	p.D50N	RCN2_ENST00000320963.5_Missense_Mutation_p.D50N|RCN2_ENST00000394883.3_Intron	NM_002902.2	NP_002893.1	Q14257	RCN2_HUMAN	reticulocalbin 2, EF-hand calcium binding domain	50						endoplasmic reticulum lumen	calcium ion binding			endometrium(2)|kidney(2)|large_intestine(2)|lung(1)	7						CCTAAAGGAAGATGTGGATGA	0.473000													4	12					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133923722	133923722	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:133923722G>A	ENST00000220616.4	+	19	4143	c.4103G>A	c.(4102-4104)tGg>tAg	p.W1368*	TG_ENST00000377869.1_Nonsense_Mutation_p.W1368*	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	1368					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AATGTTACATGGAAATCACGG	0.478000													40	71					0	0	1	0	0
RAB28	9364	broad.mit.edu	37	4	13378202	13378202	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:13378202G>A	ENST00000288723.4	-	6	754	c.540C>T	c.(538-540)atC>atT	p.I180I	RAB28_ENST00000330852.5_Silent_p.I180I|RAB28_ENST00000338176.4_Silent_p.I180I	NM_004249.3	NP_004240.2	P51157	RAB28_HUMAN	RAB28, member RAS oncogene family	180					small GTPase mediated signal transduction	plasma membrane	GDP binding|GTP binding|GTPase activity			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|skin(1)	8						TGTTTAATTTGATCCCAAGGA	0.313000													9	33					0	0	1	0	0
IGLV5-45	28781	broad.mit.edu	37	22	22730818	22730818	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:22730818C>T	ENST00000390296.2	+	0	341																											CATCTCTGGGCTCCAGTCTGA	0.517000													54	122					0	0	1	0	0
FAT4	79633	broad.mit.edu	37	4	126319956	126319956	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:126319956G>A	ENST00000394329.3	+	2	5206	c.5193G>A	c.(5191-5193)caG>caA	p.Q1731Q	FAT4_ENST00000335110.5_Silent_p.Q29Q	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	1731	Cadherin 16.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TAACACTTCAGGATATCAATG	0.428000													59	39					0	0	1	0	0
FBN2	2201	broad.mit.edu	37	5	127730909	127730909	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:127730909G>A	ENST00000508053.1	-	15	2111	c.1137C>T	c.(1135-1137)ctC>ctT	p.L379L	FBN2_ENST00000508989.1_Silent_p.L346L|FBN2_ENST00000262464.4_Silent_p.L379L			P35556	FBN2_HUMAN	fibrillin 2	379	TB 2.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TTCTCCCCGGGAGCTCTTGTG	0.532000													16	24					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	124992888	124992888	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:124992888C>T	ENST00000522917.1	+	11	1453	c.1247C>T	c.(1246-1248)tCc>tTc	p.S416F	FER1L6_ENST00000399018.1_Missense_Mutation_p.S416F	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	416						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TCTAAATTTTCCAAGGCCCTG	0.458000											OREG0018964	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	49	75					0	0	1	0	0
CREB3L4	148327	broad.mit.edu	37	1	153945460	153945460	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:153945460G>A	ENST00000368607.3	+	6	915	c.649G>A	c.(649-651)Gtc>Atc	p.V217I	CREB3L4_ENST00000405694.3_Missense_Mutation_p.V70I|CREB3L4_ENST00000368603.1_Missense_Mutation_p.V217I|CREB3L4_ENST00000271889.4_Missense_Mutation_p.V217I|CREB3L4_ENST00000468845.1_3'UTR|CREB3L4_ENST00000368601.1_3'UTR|CREB3L4_ENST00000368600.3_Missense_Mutation_p.V197I	NM_001255978.1|NM_001255980.1|NM_130898.3	NP_001242907.1|NP_001242909.1|NP_570968.1	Q8TEY5	CR3L4_HUMAN	cAMP responsive element binding protein 3-like 4	217					response to unfolded protein	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|prostate(3)	13	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			AGAGGAGAGGGTCCTCAAGAA	0.582000													81	32					0	0	1	0	0
NIPAL1	152519	broad.mit.edu	37	4	48037042	48037042	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:48037042G>A	ENST00000295461.5	+	5	672	c.606G>A	c.(604-606)atG>atA	p.M202I	NIPAL1_ENST00000508180.1_3'UTR	NM_207330.1	NP_997213.1	Q6NVV3	NIPA3_HUMAN	NIPA-like domain containing 1	202						integral to membrane				endometrium(2)|large_intestine(1)|lung(3)|skin(2)	8						AAATGGAAATGAAATTGAGAG	0.383000													43	26					0	0	1	0	0
CNTNAP2	26047	broad.mit.edu	37	7	146536850	146536850	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:146536850C>T	ENST00000361727.3	+	3	772	c.256C>T	c.(256-258)Cag>Tag	p.Q86*		NM_014141.5	NP_054860.1	Q9UHC6	CNTP2_HUMAN	contactin associated protein-like 2	86	F5/8 type C.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			NS(3)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(105)|ovary(9)|pancreas(2)|prostate(5)|skin(7)|stomach(3)|upper_aerodigestive_tract(6)|urinary_tract(3)	188	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TCAATGGCTTCAGGTTGACTT	0.473000										HNSCC(39;0.1)			24	46					0	0	1	0	0
ZNF536	9745	broad.mit.edu	37	19	30936114	30936114	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:30936114G>A	ENST00000355537.3	+	2	1792	c.1645G>A	c.(1645-1647)Gaa>Aaa	p.E549K		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	549					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					GCGCAACCACGAAGACACTTT	0.552000													48	70					0	0	1	0	0
CAPN13	92291	broad.mit.edu	37	2	31010083	31010083	+	Missense_Mutation	SNP	C	C	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:31010083C>A	ENST00000295055.8	-	2	285	c.109G>T	c.(109-111)Gat>Tat	p.D37Y	CAPN13_ENST00000534090.2_Missense_Mutation_p.D37Y|CAPN13_ENST00000465960.2_5'UTR	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	37	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					AATGTCTCATCCTTAAACGTC	0.532000													3	6					0.115264	0.115466	1	1	0
KLHL38	340359	broad.mit.edu	37	8	124664269	124664269	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:124664269T>C	ENST00000325995.7	-	1	921	c.898A>G	c.(898-900)Agg>Ggg	p.R300G	CTD-2552K11.2_ENST00000524355.1_RNA	NM_001081675.2	NP_001075144.2	Q2WGJ6	KLH38_HUMAN	kelch-like family member 38	300										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(16)|pancreas(1)|prostate(3)|stomach(1)	38						AGGACGTCCCTGGTGGTCTGC	0.567000													24	73					0	0	1	0	0
CBLC	23624	broad.mit.edu	37	19	45303658	45303658	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:45303658C>T	ENST00000270279.3	+	10	1446	c.1383C>T	c.(1381-1383)tcC>tcT	p.S461S	CBLC_ENST00000341505.4_Silent_p.S415S	NM_012116.3	NP_036248.3	Q9ULV8	CBLC_HUMAN	Cbl proto-oncogene C, E3 ubiquitin protein ligase	461					cell surface receptor linked signaling pathway|negative regulation of epidermal growth factor receptor activity|negative regulation of MAP kinase activity|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	calcium ion binding|epidermal growth factor receptor binding|phosphotyrosine binding|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding			breast(1)|kidney(1)|lung(6)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	Lung NSC(12;0.00136)|all_lung(12;0.00371)	Ovarian(192;0.231)				AGGGGAACTCCCCTCCAGCTG	0.617000			M		AML						OREG0025543	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	26					0	0	1	0	0
KLRC3	3823	broad.mit.edu	37	12	10572171	10572171	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:10572171G>A	ENST00000381904.2	-	3	307	c.308C>T	c.(307-309)tCc>tTc	p.S103F	KLRC3_ENST00000396439.2_Intron|KLRC3_ENST00000381903.2_Intron|NKG2-E_ENST00000539033.1_Intron					killer cell lectin-like receptor subfamily C, member 3											large_intestine(2)|lung(5)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	11						TGTATTTGGGGAAGAATTGTT	0.254000													14	16					0	0	1	0	0
TRAV8-1	28685	broad.mit.edu	37	14	22265811	22265811	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:22265811C>T	ENST00000390430.2	+	0	226																											CCACGTAATTCTCTCTGAAGC	0.448000													92	21					0	0	1	0	0
ZNF208	7757	broad.mit.edu	37	19	22156665	22156665	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:22156665G>A	ENST00000397126.4	-	4	1319	c.1171C>T	c.(1171-1173)Cat>Tat	p.H391Y	ZNF208_ENST00000601773.1_Intron|ZNF208_ENST00000599916.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TCTCCAGTATGAATTTTCTTA	0.378000													29	12					0	0	1	0	0
MEGF10	84466	broad.mit.edu	37	5	126792924	126792924	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:126792924C>T	ENST00000274473.6	+	26	3604	c.3337C>T	c.(3337-3339)Ctg>Ttg	p.L1113L	MEGF10_ENST00000503335.2_Silent_p.L1113L	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	1113	Necessary for formation of large intracellular vacuoles.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		TCATTATGACCTGCTGCCAGT	0.517000													41	53					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11039366	11039366	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:11039366G>A	ENST00000470054.1	-	0	837									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		CTTCACTTCAGAAGACATTTT	0.353000													18	196					0	0	1	0	0
CACNA2D3	55799	broad.mit.edu	37	3	54930778	54930778	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:54930778A>T	ENST00000474759.1	+	26	2297	c.2249A>T	c.(2248-2250)gAc>gTc	p.D750V	CACNA2D3_ENST00000415676.2_Missense_Mutation_p.D750V|CACNA2D3_ENST00000490478.1_Missense_Mutation_p.D656V|CACNA2D3_ENST00000288197.5_Missense_Mutation_p.D750V|CACNA2D3-AS1_ENST00000471265.1_RNA	NM_018398.2	NP_060868.2	Q8IZS8	CA2D3_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 3	750						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(17)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(3)	59				KIRC - Kidney renal clear cell carcinoma(284;0.00287)|Kidney(284;0.00327)		ACTTCAAGGGACTTCCTGAAA	0.507000													38	62					0	0	1	0	0
ABCC4	10257	broad.mit.edu	37	13	95715076	95715076	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:95715076G>A	ENST00000376887.4	-	26	3362	c.3248C>T	c.(3247-3249)tCc>tTc	p.S1083F	ABCC4_ENST00000412704.1_Missense_Mutation_p.S1036F	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	1083	ABC transporter 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	TGAGATGAGGGAACTTTTTCC	0.403000													27	30					0	0	1	0	0
CNTN6	27255	broad.mit.edu	37	3	1269557	1269557	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:1269557G>A	ENST00000446702.2	+	4	865	c.238G>A	c.(238-240)Gat>Aat	p.D80N	CNTN6_ENST00000350110.2_Missense_Mutation_p.D80N|CNTN6_ENST00000539053.1_Missense_Mutation_p.D8N			Q9UQ52	CNTN6_HUMAN	contactin 6	80	Ig-like C2-type 1.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				breast(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(34)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	90		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		CTACAGGTTGGATGGAGGCAG	0.413000													27	41					0	0	1	0	0
OCIAD2	132299	broad.mit.edu	37	4	48906539	48906539	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:48906539G>A	ENST00000508632.1	-	2	260	c.28C>T	c.(28-30)Caa>Taa	p.Q10*	OCIAD2_ENST00000508069.2_5'UTR|OCIAD2_ENST00000273860.4_Nonsense_Mutation_p.Q10*	NM_001014446.1	NP_001014446.1	Q56VL3	OCAD2_HUMAN	OCIA domain containing 2	10	OCIA.					endosome				kidney(1)|lung(3)|skin(1)|urinary_tract(1)	6						TCTTTATCTTGGTTTCCACGA	0.443000													20	61					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125131170	125131170	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:125131170C>T	ENST00000522917.1	+	40	5581	c.5375C>T	c.(5374-5376)cCc>cTc	p.P1792L	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Missense_Mutation_p.P1792L	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1792						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GAGCCAGAGCCCCTGGCCAAG	0.498000													12	18					0	0	1	0	0
SH2D4A	63898	broad.mit.edu	37	8	19221777	19221777	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:19221777C>T	ENST00000265807.3	+	7	1312	c.901C>T	c.(901-903)Cct>Tct	p.P301S	SH2D4A_ENST00000519207.1_Missense_Mutation_p.P301S|SH2D4A_ENST00000518040.1_Missense_Mutation_p.P256S	NM_001174160.1|NM_022071.3	NP_001167631.1|NP_071354.2	Q9H788	SH24A_HUMAN	SH2 domain containing 4A	301						cytoplasm|nucleus	protein binding			endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|stomach(1)	16				Colorectal(111;0.0732)		AGGGGCATATCCTCAAAAACC	0.473000													18	32					0	0	1	0	0
HIRA	7290	broad.mit.edu	37	22	19319035	19319035	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:19319035G>A	ENST00000263208.5	-	25	3238	c.2982C>T	c.(2980-2982)atC>atT	p.I994I	HIRA_ENST00000340170.4_Silent_p.I787I|HIRA_ENST00000541063.1_Silent_p.I950I	NM_003325.3	NP_003316.3	P54198	HIRA_HUMAN	histone cell cycle regulator	994	Interaction with histone H4.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)|prostate(1)|skin(1)	37	Colorectal(54;0.0993)					GGTTCTGCCCGATGACTGGTA	0.587000													14	66					0	0	1	0	0
ACAN	176	broad.mit.edu	37	15	89401560	89401560	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:89401560G>A	ENST00000439576.2	+	12	6118	c.5744G>A	c.(5743-5745)aGc>aAc	p.S1915N	ACAN_ENST00000559004.1_Missense_Mutation_p.S1915N|ACAN_ENST00000561243.1_Missense_Mutation_p.S1915N|ACAN_ENST00000352105.7_Missense_Mutation_p.S1915N	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	1915					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GAGATTGGGAGCAGCCTGCCC	0.522000													14	40					0	0	1	0	0
CPA6	57094	broad.mit.edu	37	8	68419059	68419059	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:68419059C>T	ENST00000297770.4	-	6	814	c.599G>A	c.(598-600)tGg>tAg	p.W200*	CPA6_ENST00000518549.1_Nonsense_Mutation_p.W200*|CPA6_ENST00000297769.4_Nonsense_Mutation_p.W52*	NM_020361.4	NP_065094.3	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6	200					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(3)|skin(5)	26			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			AGGACCAATCCATTCTCTTGC	0.423000													27	32					0	0	1	0	0
TIMD4	91937	broad.mit.edu	37	5	156378773	156378773	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:156378773G>A	ENST00000274532.2	-	3	485	c.429C>T	c.(427-429)acC>acT	p.T143T	TIMD4_ENST00000407087.3_Silent_p.T143T	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	143	Thr-rich.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTGTGGTGGTGGTTGCTGTTC	0.498000													93	182					0	0	1	0	0
TFAP4	7023	broad.mit.edu	37	16	4310150	4310150	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:4310150G>A	ENST00000204517.6	-	6	1091	c.763C>T	c.(763-765)Ccc>Tcc	p.P255S		NM_003223.2	NP_003214.1	Q01664	TFAP4_HUMAN	transcription factor AP-4 (activating enhancer binding protein 4)	255					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation by host of viral transcription|negative regulation of cell cycle arrest|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|positive regulation by host of viral transcription|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|regulation of S phase of mitotic cell cycle	transcriptional repressor complex	E-box binding|histone deacetylase binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			NS(1)|endometrium(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	14						ACCGAGGAGGGGCCCATGGTG	0.622000													39	48					0	0	1	0	0
SCARA5	286133	broad.mit.edu	37	8	27845080	27845080	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:27845080G>A	ENST00000354914.3	-	2	538	c.53C>T	c.(52-54)tCc>tTc	p.S18F	SCARA5_ENST00000524352.1_Missense_Mutation_p.S18F|SCARA5_ENST00000518030.1_Missense_Mutation_p.S18F|SCARA5_ENST00000380385.2_Missense_Mutation_p.S18F|SCARA5_ENST00000301906.4_Missense_Mutation_p.S18F	NM_173833.5	NP_776194.2	Q6ZMJ2	SCAR5_HUMAN	scavenger receptor class A, member 5 (putative)	18					cellular iron ion homeostasis|endocytosis|iron ion transmembrane transport|protein homotrimerization	integral to plasma membrane	ferritin receptor activity|scavenger receptor activity			central_nervous_system(1)|large_intestine(6)|lung(5)|prostate(3)|skin(3)	18		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.023)|KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)|Colorectal(74;0.228)		CTCACAGATGGAGCTGGTGTC	0.562000													32	59					0	0	1	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47533279	47533279	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:47533279G>A	ENST00000334194.3	+	1	120	c.117G>A	c.(115-117)atG>atA	p.M39I		NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	39						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						GGAGATGGATGATCAGAGCCC	0.522000													52	21					0	0	1	0	0
SLC16A14	151473	broad.mit.edu	37	2	230911259	230911259	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:230911259G>A	ENST00000295190.4	-	4	1041	c.583C>T	c.(583-585)Caa>Taa	p.Q195*		NM_152527.4	NP_689740.2	Q7RTX9	MOT14_HUMAN	solute carrier family 16, member 14	195						integral to membrane|plasma membrane	symporter activity			NS(1)|cervix(1)|endometrium(7)|large_intestine(7)|lung(3)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		ACGGCACCTTGGATCAACATG	0.567000													59	99					0	0	1	0	0
FBXO10	26267	broad.mit.edu	37	9	37521635	37521635	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:37521635C>T	ENST00000432825.2	-	8	2179	c.2131G>A	c.(2131-2133)Gag>Aag	p.E711K	FBXO10_ENST00000541829.1_Missense_Mutation_p.E236K|RP11-613M10.8_ENST00000544475.1_5'UTR	NM_012166.2	NP_036298.2	Q9UK96	FBX10_HUMAN	F-box protein 10	711						ubiquitin ligase complex	ubiquitin-protein ligase activity			breast(1)|endometrium(5)|large_intestine(11)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	34				GBM - Glioblastoma multiforme(29;0.0107)		GGGTCGTCCTCCTTCTCCAGC	0.567000													16	4					0	0	1	0	0
TIE1	7075	broad.mit.edu	37	1	43778223	43778223	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:43778223C>T	ENST00000372476.3	+	12	1957	c.1878C>T	c.(1876-1878)acC>acT	p.T626T	TIE1_ENST00000433781.2_Silent_p.T271T	NM_001253357.1|NM_005424.4	NP_001240286.1|NP_005415.1	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	626	Fibronectin type-III 2.				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(8)|lung(28)|ovary(3)|prostate(2)|salivary_gland(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	70	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACCACTGCACCCTCCTGGGCC	0.682000													10	83					0	0	1	0	0
MCOLN3	55283	broad.mit.edu	37	1	85484831	85484831	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:85484831G>T	ENST00000370589.2	-	13	1689	c.1637C>A	c.(1636-1638)tCt>tAt	p.S546Y	MCOLN3_ENST00000341115.4_Missense_Mutation_p.S490Y|WDR63_ENST00000370596.1_Intron|MCOLN3_ENST00000474447.1_5'UTR	NM_018298.10	NP_060768.8	Q8TDD5	MCLN3_HUMAN	mucolipin 3	546						integral to membrane	ion channel activity			endometrium(6)|kidney(3)|large_intestine(9)|lung(12)|prostate(3)|skin(1)	34				all cancers(265;0.00957)|Epithelial(280;0.0254)		GCAGAATAAAGATACTGGAGG	0.373000													12	56					2.68362e-12	2.70971e-12	1	1	0
STAB2	55576	broad.mit.edu	37	12	104140482	104140482	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:104140482G>A	ENST00000388887.2	+	58	6448	c.6244_splice	c.e58+1	p.V2082_splice	RP11-341G23.4_ENST00000551299.1_RNA	NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	2082	EGF-like 16.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						CACATGCACAGGTAAGCCACC	0.527000													69	68					0	0	1	0	0
FOXJ3	22887	broad.mit.edu	37	1	42657234	42657234	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:42657234G>A	ENST00000372572.1	-	11	1402	c.1091C>T	c.(1090-1092)tCg>tTg	p.S364L	FOXJ3_ENST00000361776.1_Missense_Mutation_p.S330L|FOXJ3_ENST00000361346.1_Missense_Mutation_p.S364L|FOXJ3_ENST00000372573.1_Missense_Mutation_p.S364L|FOXJ3_ENST00000545068.1_Missense_Mutation_p.S364L	NM_001198851.1	NP_001185780.1	Q9UPW0	FOXJ3_HUMAN	forkhead box J3	364					embryo development|organ development|pattern specification process|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein domain specific binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	18	Ovarian(52;0.01)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CTGTGCAACCGAATTACTGCC	0.577000													23	189					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107049684	107049684	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:107049684C>T	ENST00000409886.3	-	16	2350	c.2263G>A	c.(2263-2265)Gaa>Aaa	p.E755K	RGPD3_ENST00000304514.7_Missense_Mutation_p.E755K	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	755					intracellular transport		binding			breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						CTATAGTTTTCGAGTTCCTGC	0.368000													71	270					0	0	1	0	0
FABP12	646486	broad.mit.edu	37	8	82441737	82441737	+	Missense_Mutation	SNP	T	T	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:82441737T>A	ENST00000360464.4	-	2	244	c.182A>T	c.(181-183)aAt>aTt	p.N61I	RP11-257P3.3_ENST00000523380.1_RNA	NM_001105281.1	NP_001098751.1	A6NFH5	FBP12_HUMAN	fatty acid binding protein 12	61							lipid binding|transporter activity			large_intestine(1)|lung(3)	4						GGAGATCTCATTATTTTTAAA	0.438000													31	36					0	0	1	0	0
CTNNA3	29119	broad.mit.edu	37	10	68940198	68940198	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:68940198G>A	ENST00000433211.1	-	7	1098	c.924C>T	c.(922-924)atC>atT	p.I308I	CTNNA3_ENST00000545309.1_Silent_p.I308I|CTNNA3_ENST00000494580.1_5'UTR|CTNNA3_ENST00000373744.4_Silent_p.I308I	NM_013266.2	NP_037398.2	Q9UI47	CTNA3_HUMAN	catenin (cadherin-associated protein), alpha 3	308					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|liver(1)|lung(50)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|stomach(1)|urinary_tract(1)	95						CAGCCCCACTGATAATGGCTT	0.478000													27	7					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19725220	19725220	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:19725220C>T	ENST00000284885.3	-	10	1204	c.1171_splice	c.e10+1	p.G391_splice		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	391	MAM.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						TGAATTATACCTGAAGCATTG	0.348000													33	63					0	0	1	0	0
CD1D	912	broad.mit.edu	37	1	158152894	158152894	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:158152894C>T	ENST00000368171.3	+	5	1333	c.834C>T	c.(832-834)tcC>tcT	p.S278S		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	278	Ig-like.				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					CTGGCCTGTCCTGTCGGGTGA	0.607000													87	38					0	0	1	0	0
KEL	3792	broad.mit.edu	37	7	142655480	142655480	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:142655480C>T	ENST00000355265.2	-	5	910	c.436G>A	c.(436-438)Gag>Aag	p.E146K	KEL_ENST00000479768.2_5'UTR	NM_000420.2	NP_000411.1	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	146					proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(11)|lung(34)|ovary(3)|prostate(2)|skin(1)	60	Melanoma(164;0.059)					AAGGCTTTCTCCTCCCCAGAG	0.478000													14	25					0	0	1	0	0
ABCC1	4363	broad.mit.edu	37	16	16200609	16200609	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:16200609C>T	ENST00000399408.2	+	22	2955	c.2780C>T	c.(2779-2781)tCc>tTc	p.S927F	ABCC1_ENST00000345148.5_Missense_Mutation_p.S917F|ABCC1_ENST00000351154.5_Missense_Mutation_p.S858F|ABCC1_ENST00000576557.1_3'UTR|ABCC1_ENST00000399410.3_Missense_Mutation_p.S917F|ABCC1_ENST00000349029.5_Missense_Mutation_p.S802F|ABCC1_ENST00000346370.5_Missense_Mutation_p.S861F			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	917					hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CTCAGCAGCTCCTCCTCCTAT	0.582000													15	46					0	0	1	0	0
TMEM74	157753	broad.mit.edu	37	8	109796761	109796761	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:109796761G>A	ENST00000297459.3	-	2	745	c.567C>T	c.(565-567)atC>atT	p.I189I	TMEM74_ENST00000518838.1_Intron	NM_153015.1	NP_694560.1	Q96NL1	TMM74_HUMAN	transmembrane protein 74	189					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(57;3.08e-10)			TCACGAGCAGGATCCCAGTGA	0.527000													22	46					0	0	1	0	0
GPRC5C	55890	broad.mit.edu	37	17	72436587	72436587	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:72436587C>T	ENST00000392627.1	+	2	1933	c.807C>T	c.(805-807)ttC>ttT	p.F269F	GPRC5C_ENST00000392629.2_Silent_p.F236F|GPRC5C_ENST00000342648.5_Intron|GPRC5C_ENST00000481232.1_Intron	NM_022036.2	NP_071319.2	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor, family C, group 5, member C	224						cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	17						TGGGTGCCTTCCTGGGGGCCT	0.642000													9	32					0	0	1	0	0
VPS54	51542	broad.mit.edu	37	2	64176286	64176286	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:64176286G>A	ENST00000354504.3	-	6	1260	c.671C>T	c.(670-672)tCa>tTa	p.S224L	VPS54_ENST00000409558.3_Missense_Mutation_p.S329L|VPS54_ENST00000272322.4_Missense_Mutation_p.S341L			Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 homolog (S. cerevisiae)	341					protein transport|retrograde transport, endosome to Golgi					endometrium(3)|kidney(4)|large_intestine(8)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)	27						ACAAAGCTGTGATCCCAAATG	0.313000													6	5					0	0	1	0	0
STK31	56164	broad.mit.edu	37	7	23793972	23793972	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:23793972C>T	ENST00000354639.3	+	10	1567	c.1103C>T	c.(1102-1104)tCa>tTa	p.S368L	STK31_ENST00000433467.2_Missense_Mutation_p.S391L|STK31_ENST00000355870.3_Missense_Mutation_p.S391L|STK31_ENST00000405627.3_3'UTR|STK31_ENST00000428484.1_Missense_Mutation_p.S368L	NM_001260504.1|NM_032944.3	NP_001247433.1|NP_116562.2	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31	391							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(31)|ovary(2)|prostate(1)|skin(7)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	67						AAAGACCTTTCAGATGCTATA	0.378000													33	70					0	0	1	0	0
ARMC4	55130	broad.mit.edu	37	10	28223949	28223949	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:28223949C>T	ENST00000305242.5	-	16	2577	c.2485G>A	c.(2485-2487)Gaa>Aaa	p.E829K	ARMC4_ENST00000537576.1_Missense_Mutation_p.E521K|ARMC4_ENST00000545014.1_Missense_Mutation_p.E354K	NM_018076.2	NP_060546.2	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	829							binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(17)|liver(1)|lung(17)|ovary(5)|prostate(3)|skin(8)|stomach(2)|urinary_tract(3)	75						ATCATACTTTCAGGTTCTACT	0.408000													26	16					0	0	1	0	0
CBX4	8535	broad.mit.edu	37	17	77808568	77808568	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:77808568G>A	ENST00000269397.4	-	5	1050	c.873C>T	c.(871-873)tcC>tcT	p.S291S		NM_003655.2	NP_003646.2	O00257	CBX4_HUMAN	chromobox homolog 4	291	Interaction with BMI1.				anti-apoptosis|chromatin modification|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|PcG protein complex	enzyme binding|transcription corepressor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	18			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			TGTGGCTGGGGGAGCGAGCCT	0.632000											OREG0024799	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	85					0	0	1	0	0
PSG3	5671	broad.mit.edu	37	19	43233934	43233934	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:43233934G>A	ENST00000327495.5	-	4	1168	c.984C>T	c.(982-984)gtC>gtT	p.V328V	PSG3_ENST00000595140.1_Silent_p.V328V	NM_021016.3	NP_066296.2	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	328					defense response|female pregnancy	extracellular region				central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	36		Prostate(69;0.00682)				ACTCACAGAGGACATTCAGGG	0.488000													52	64					0	0	1	0	0
GBA	2629	broad.mit.edu	37	1	155207281	155207281	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:155207281G>A	ENST00000428024.2	-	6	1091	c.589C>T	c.(589-591)Ccc>Tcc	p.P197S	GBA_ENST00000427500.2_Missense_Mutation_p.P235S|GBA_ENST00000327247.5_Missense_Mutation_p.P284S|GBA_ENST00000536770.1_Missense_Mutation_p.P171S|GBA_ENST00000368373.3_Missense_Mutation_p.P284S	NM_001171811.1	NP_001165282.1	P04062	GLCM_HUMAN	glucosidase, beta, acid	284					carbohydrate metabolic process|cell death|cellular response to tumor necrosis factor|ceramide biosynthetic process|glucosylceramide catabolic process|lysosome organization|negative regulation of interleukin-6 production|negative regulation of MAP kinase activity|positive regulation of protein dephosphorylation|sphingosine biosynthetic process|termination of signal transduction	lysosomal lumen|lysosomal membrane	cation binding|glucosylceramidase activity|receptor binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	26	all_lung(78;2.32e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)		Alglucerase(DB00088)|Imiglucerase(DB00053)	CACTGGAAGGGGTATCCACTC	0.547000									Gaucher disease type I				6	43					0	0	1	0	0
SFRP1	6422	broad.mit.edu	37	8	41122808	41122808	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:41122808C>T	ENST00000220772.3	-	3	1160	c.823G>A	c.(823-825)Gtg>Atg	p.V275M	SFRP1_ENST00000379845.3_Missense_Mutation_p.V139M	NM_003012.4	NP_003003.3	Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1	275	NTR.				brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|liver(1)|lung(1)|skin(1)	7	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			TGGCTCTTCACCTTGCGGCCC	0.512000													35	61					0	0	1	0	0
HEATR2	54919	broad.mit.edu	37	7	794309	794309	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:794309G>A	ENST00000297440.6	+	5	1128	c.1108G>A	c.(1108-1110)Gac>Aac	p.D370N	HEATR2_ENST00000313147.5_Missense_Mutation_p.D370N	NM_017802.3	NP_060272.3	Q86Y56	HEAT2_HUMAN	HEAT repeat containing 2	370							protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(2)|prostate(4)|skin(1)	22		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0182)|Epithelial(4;5.48e-17)|OV - Ovarian serous cystadenocarcinoma(56;1.95e-16)|all cancers(6;2.98e-14)		CGACATCACCGACTGGGTGGT	0.657000													62	105					0	0	1	0	0
KCNV1	27012	broad.mit.edu	37	8	110984721	110984721	+	Missense_Mutation	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:110984721A>G	ENST00000524391.1	-	3	1789	c.757T>C	c.(757-759)Ttc>Ctc	p.F253L	KCNV1_ENST00000297404.1_Missense_Mutation_p.F253L			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	253						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			TCCCCGGTGAACCAGCTAATG	0.537000													19	52					0	0	1	0	0
YARS	8565	broad.mit.edu	37	1	33282819	33282819	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:33282819C>T	ENST00000373477.4	-	1	935	c.27G>A	c.(25-27)gaG>gaA	p.E9E		NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	9					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	GGTGCAGTTTCTCTTCAGGGC	0.652000													22	130					0	0	1	0	0
OR52N2	390077	broad.mit.edu	37	11	5842048	5842048	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:5842048C>T	ENST00000317037.2	+	1	505	c.483C>T	c.(481-483)ttC>ttT	p.F161F	TRIM5_ENST00000380027.1_Intron	NM_001005174.1	NP_001005174.1	Q8NGI0	O52N2_HUMAN	olfactory receptor, family 52, subfamily N, member 2	161					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|urinary_tract(1)	32		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.49e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCATCCCATTCACTCTCCTCA	0.537000													51	78					0	0	1	0	0
L3MBTL1	26013	broad.mit.edu	37	20	42143675	42143675	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:42143675G>A	ENST00000444063.1	+	2	391	c.259G>A	c.(259-261)Gat>Aat	p.D87N	L3MBTL1_ENST00000373134.1_Missense_Mutation_p.D87N|L3MBTL1_ENST00000418998.1_Missense_Mutation_p.D155N|L3MBTL1_ENST00000373135.3_Missense_Mutation_p.D87N|L3MBTL1_ENST00000427442.2_Missense_Mutation_p.D155N|L3MBTL1_ENST00000457824.1_3'UTR			Q9Y468	LMBL1_HUMAN	l(3)mbt-like 1 (Drosophila)	87					chromatin modification|hemopoiesis|negative regulation of transcription, DNA-dependent|regulation of megakaryocyte differentiation|regulation of mitosis	chromatin|condensed chromosome|nucleoplasm	identical protein binding|methylated histone residue binding|nucleosomal histone binding|SAM domain binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|large_intestine(3)|ovary(1)|skin(2)	7						TCCTCCAGAAGATCCCAATCA	0.647000													16	39					0	0	1	0	0
MYO1G	64005	broad.mit.edu	37	7	45010581	45010581	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:45010581C>T	ENST00000258787.7	-	8	1060	c.924G>A	c.(922-924)gtG>gtA	p.V308V		NM_033054.2	NP_149043.2	B0I1T2	MYO1G_HUMAN	myosin IG	308	Myosin head-like.					myosin complex|plasma membrane	actin binding|ATP binding|calmodulin binding|motor activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|pancreas(1)|skin(4)	28						CCACATGGTCCACCAGTGCCT	0.632000													13	23					0	0	1	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50188994	50188994	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:50188994G>A	ENST00000335999.6	-	8	2850	c.2649C>T	c.(2647-2649)atC>atT	p.I883I		NM_001037806.3	NP_001032895.2	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	879										central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(8)|prostate(2)	18						CCTTCTCCTCGATGGCTGAGT	0.657000													46	35					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179534944	179534944	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179534944C>T	ENST00000589042.1	-	157	35611		c.e157+1		TTN_ENST00000342992.6_Splice_Site|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Splice_Site|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin								ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAGCCAGTTACCTTTAGTTGG	0.353000													7	13					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123744131	123744131	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:123744131G>A	ENST00000223642.1	-	27	3506	c.3477C>T	c.(3475-3477)tgC>tgT	p.C1159C		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	1159					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	CCACCAGGGGGCATATATCGA	0.413000													19	4					0	0	1	0	0
ZBTB39	9880	broad.mit.edu	37	12	57397310	57397310	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:57397310G>A	ENST00000300101.2	-	2	1477	c.1392C>T	c.(1390-1392)ttC>ttT	p.F464F		NM_014830.2	NP_055645.1	O15060	ZBT39_HUMAN	zinc finger and BTB domain containing 39	464					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|liver(1)|lung(3)|prostate(1)	16						GGACCACATGGAAATCTTTGG	0.582000													21	24					0	0	1	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882732	228882732	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:228882732C>T	ENST00000392056.3	-	7	2884	c.2838G>A	c.(2836-2838)gcG>gcA	p.A946A	SPHKAP_ENST00000344657.5_Silent_p.A946A	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	946	PKA-RII subunit binding domain (By similarity).					cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CAAGGCAAATCGCTGCAATTT	0.473000													43	85					0	0	1	0	0
TSPAN32	10077	broad.mit.edu	37	11	2338710	2338710	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:2338710G>T	ENST00000182290.4	+	9	993	c.856G>T	c.(856-858)Gat>Tat	p.D286Y	TSPAN32_ENST00000451520.2_Missense_Mutation_p.D275Y|TSPAN32_ENST00000381121.3_Intron	NM_139022.2	NP_620591.3	Q96QS1	TSN32_HUMAN	tetraspanin 32	286					cell-cell signaling	integral to membrane				breast(1)|central_nervous_system(1)|lung(4)|ovary(1)|skin(1)	8		all_epithelial(84;4.89e-05)|Breast(177;0.000962)|Medulloblastoma(188;0.00106)|Ovarian(85;0.0014)|all_neural(188;0.00791)|Lung NSC(207;0.209)		BRCA - Breast invasive adenocarcinoma(625;0.000533)|LUSC - Lung squamous cell carcinoma(625;0.082)|Lung(200;0.153)		GCAGGAGAGCGATGCTGCGCC	0.632000													5	4					1	1	1	1	0
LIN28B	389421	broad.mit.edu	37	6	105474268	105474268	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:105474268G>A	ENST00000345080.4	+	3	497	c.294G>A	c.(292-294)cgG>cgA	p.R98R		NM_001004317.3	NP_001004317.1	Q6ZN17	LN28B_HUMAN	lin-28 homolog B (C. elegans)	98	CSD.				miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing	cytoplasm|nucleus	DNA binding|protein binding|RNA binding|zinc ion binding			large_intestine(1)|lung(10)|ovary(1)	12		all_cancers(87;0.00346)|Acute lymphoblastic leukemia(125;2.26e-08)|all_hematologic(75;2.79e-06)|all_epithelial(87;0.204)				AGTCAATACGGGTAACAGGAC	0.408000													103	85					0	0	1	0	0
CNR2	1269	broad.mit.edu	37	1	24201850	24201850	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:24201850G>A	ENST00000536471.1	-	3	516	c.258C>T	c.(256-258)gtC>gtT	p.V86V	CNR2_ENST00000374472.4_Silent_p.V86V			P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	86					behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|lung(9)|pancreas(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(2)	26		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	TGCATGCAAAGACCACACTGG	0.532000													67	38					0	0	1	0	0
DSCAML1	57453	broad.mit.edu	37	11	117375660	117375660	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:117375660C>T	ENST00000321322.6	-	10	2342	c.2341G>A	c.(2341-2343)Gtc>Atc	p.V781I	DSCAML1_ENST00000527706.1_Missense_Mutation_p.V511I	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	721	Ig-like C2-type 8.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TTCCACATGACCTTGGGTGGG	0.592000													21	34					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156837938	156837938	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:156837938C>T	ENST00000368196.3	+	5	591	c.471C>T	c.(469-471)cgC>cgT	p.R157R	NTRK1_ENST00000358660.3_Silent_p.R157R|NTRK1_ENST00000524377.1_Silent_p.R157R|NTRK1_ENST00000392302.2_Silent_p.R127R	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	157	LRRCT.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GTGCCCTGCGCTGGCTACAGC	0.647000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			13	101					0	0	1	0	0
KRT18	3875	broad.mit.edu	37	12	53345616	53345616	+	Silent	SNP	C	C	T	rs149270992		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:53345616C>T	ENST00000550600.1	+	6	978	c.924C>T	c.(922-924)atC>atT	p.I308I	KRT18_ENST00000388835.3_Silent_p.I308I|KRT18_ENST00000388837.2_Silent_p.I308I			P05783	K1C18_HUMAN	keratin 18	308	Coil 2.|Interaction with DNAJB6.|Necessary for interaction with PNN.|Rod.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			central_nervous_system(1)|large_intestine(2)|lung(4)|prostate(3)|skin(1)	11						CCTTGGAGATCGACCTGGACT	0.557000													17	15					0	0	1	0	0
ADAMTS13	11093	broad.mit.edu	37	9	136291092	136291092	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:136291092C>T	ENST00000371929.3	+	5	893	c.449C>T	c.(448-450)tCc>tTc	p.S150F	ADAMTS13_ENST00000485925.1_3'UTR|ADAMTS13_ENST00000355699.2_Missense_Mutation_p.S150F|ADAMTS13_ENST00000371916.1_Missense_Mutation_p.S150F|ADAMTS13_ENST00000356589.2_Missense_Mutation_p.S150F|ADAMTS13_ENST00000371911.3_Missense_Mutation_p.S150F	NM_139025.3|NM_139027.3	NP_620594.1|NP_620596.2	Q76LX8	ATS13_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 13	150	Peptidase M12B.				cell-matrix adhesion|glycoprotein metabolic process|integrin-mediated signaling pathway|peptide catabolic process|platelet activation|protein processing|proteolysis	cell surface|proteinaceous extracellular matrix	calcium ion binding|integrin binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(4)	36				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		CTCACCTCGTCCCTGCTGAGC	0.607000													25	11					0	0	1	0	0
CNR1	1268	broad.mit.edu	37	6	88854232	88854232	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:88854232G>A	ENST00000537554.1	-	2	4324	c.762C>T	c.(760-762)ggC>ggT	p.G254G	CNR1_ENST00000468898.1_Silent_p.G221G|CNR1_ENST00000535130.1_Silent_p.G254G|CNR1_ENST00000549890.1_Silent_p.G254G|CNR1_ENST00000428600.2_Silent_p.G254G|CNR1_ENST00000549716.1_Silent_p.G193G|CNR1_ENST00000362094.5_3'UTR|CNR1_ENST00000369501.2_Silent_p.G254G|CNR1_ENST00000369499.2_Silent_p.G254G	NM_001160226.1|NM_001160258.1	NP_001153698.1|NP_001153730.1	P21554	CNR1_HUMAN	cannabinoid receptor 1 (brain)	254					G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|prostate(1)|skin(10)|urinary_tract(1)	37		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	CGCAGTTCCAGCCCAGGAGAG	0.542000													40	28					0	0	1	0	0
THEMIS	387357	broad.mit.edu	37	6	128134908	128134908	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:128134908C>T	ENST00000368250.1	-	5	1139	c.641G>A	c.(640-642)gGa>gAa	p.G214E	THEMIS_ENST00000368248.2_Missense_Mutation_p.G293E|THEMIS_ENST00000543064.1_Missense_Mutation_p.G293E|THEMIS_ENST00000537166.1_Missense_Mutation_p.G258E			Q8N1K5	THMS1_HUMAN	thymocyte selection associated	293	CABIT 1.				negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(3)	60						CAGGTGGTTTCCTTCAGGTGC	0.403000													28	90					0	0	1	0	0
SLC4A5	57835	broad.mit.edu	37	2	74466470	74466470	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:74466470G>A	ENST00000394019.2	-	21	2708	c.2311C>T	c.(2311-2313)Cct>Tct	p.P771S	SLC4A5_ENST00000346834.4_Missense_Mutation_p.P771S|SLC4A5_ENST00000359484.4_Missense_Mutation_p.P707S|SLC4A5_ENST00000377632.1_Missense_Mutation_p.P771S|SLC4A5_ENST00000377634.4_Missense_Mutation_p.P771S|SLC4A5_ENST00000358683.4_Missense_Mutation_p.P707S|SLC4A5_ENST00000423644.1_Missense_Mutation_p.P771S|SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000357822.5_Missense_Mutation_p.P771S|RP11-287D1.3_ENST00000451608.2_3'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	771						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						ACCTTGGTAGGAAAATAGCGG	0.532000													21	36					0	0	1	0	0
FFAR4	338557	broad.mit.edu	37	10	95335855	95335855	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:95335855C>T	ENST00000371483.4	+	2	631	c.575C>T	c.(574-576)tCg>tTg	p.S192L	FFAR4_ENST00000371481.4_Missense_Mutation_p.S192L|FFAR4_ENST00000604414.1_Missense_Mutation_p.S192L	NM_181745.3	NP_859529.2			free fatty acid receptor 4																		TAGGAAATTTCGATTTGCACA	0.438000													24	19					0	0	1	0	0
KDR	3791	broad.mit.edu	37	4	55956220	55956220	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:55956220C>T	ENST00000263923.4	-	23	3390	c.3095G>A	c.(3094-3096)cGa>cAa	p.R1032Q	RP11-530I17.1_ENST00000511222.1_RNA	NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	1032	Protein kinase.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity	p.R1032Q(2)		NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GAGGATATTTCGTGCCGCCAG	0.448000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			40	23					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228509697	228509697	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:228509697G>C	ENST00000570156.2	+	66	18100	c.18026G>C	c.(18025-18027)cGc>cCc	p.R6009P	OBSCN_ENST00000284548.11_Missense_Mutation_p.R5052P|OBSCN_ENST00000366707.4_Missense_Mutation_p.R2686P|OBSCN_ENST00000366709.4_Missense_Mutation_p.R2171P|OBSCN_ENST00000422127.1_Missense_Mutation_p.R5052P	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	5052					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				CAGACATACCGCGAAGATGAG	0.592000													5	11					0	0	1	0	0
MED13	9969	broad.mit.edu	37	17	60040271	60040271	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:60040271G>A	ENST00000397786.2	-	21	4982	c.4906C>T	c.(4906-4908)Cca>Tca	p.P1636S		NM_005121.2	NP_005112.2	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1636					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(4)|central_nervous_system(1)|endometrium(10)|kidney(24)|large_intestine(15)|liver(1)|lung(20)|ovary(1)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						ATTGCAGGTGGATACGTGACT	0.403000													30	56					0	0	1	0	0
EYA1	2138	broad.mit.edu	37	8	72211898	72211898	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:72211898G>A	ENST00000340726.3	-	8	1253	c.614C>T	c.(613-615)tCc>tTc	p.S205F	EYA1_ENST00000419131.1_Missense_Mutation_p.S200F|EYA1_ENST00000388740.3_Missense_Mutation_p.S172F|EYA1_ENST00000388743.2_Missense_Mutation_p.S204F|EYA1_ENST00000303824.7_Missense_Mutation_p.S199F|EYA1_ENST00000388742.4_Missense_Mutation_p.S205F|EYA1_ENST00000388741.2_Missense_Mutation_p.S171F	NM_000503.4	NP_000494.2	Q99502	EYA1_HUMAN	eyes absent homolog 1 (Drosophila)	205					double-strand break repair|histone dephosphorylation|positive regulation of DNA repair|protein sumoylation|regulation of transcription, DNA-dependent|response to ionizing radiation|sensory perception of sound|transcription, DNA-dependent	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			NS(2)|breast(3)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(15)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	44	Breast(64;0.046)		Epithelial(68;0.0837)|all cancers(69;0.247)			AAATCCAGAGGAATTTGTGAG	0.299000													24	40					0	0	1	0	0
GPR110	266977	broad.mit.edu	37	6	46996735	46996735	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:46996735G>A	ENST00000371253.2	-	2	278	c.63C>T	c.(61-63)ttC>ttT	p.F21F	GPR110_ENST00000449332.2_5'UTR|GPR110_ENST00000371243.2_Silent_p.F21F	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	21					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						TCACCCCCAGGAAGCCACCGT	0.517000													32	51					0	0	1	0	0
FLI1	2313	broad.mit.edu	37	11	128634703	128634703	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:128634703G>A	ENST00000281428.8	+	1	19	c.19G>A	c.(19-21)Ggc>Agc	p.G7S	FLI1_ENST00000429175.2_Intron|FLI1_ENST00000534087.1_Intron|FLI1_ENST00000344954.6_Intron|FLI1_ENST00000527767.2_Intron|FLI1_ENST00000525560.1_Intron	NM_001271010.1	NP_001257939.1	Q01543	FLI1_HUMAN	Fli-1 proto-oncogene, ETS transcription factor	0					hemostasis|organ morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		EWSR1/FLI1(2569)	NS(1)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(2)	31	all_hematologic(175;0.0641)	Lung NSC(97;0.00588)|all_lung(97;0.00764)|Breast(109;0.0115)|Medulloblastoma(222;0.0523)|all_neural(223;0.0862)|all_hematologic(192;0.182)		OV - Ovarian serous cystadenocarcinoma(99;0.01)|LUSC - Lung squamous cell carcinoma(976;0.0324)|Lung(977;0.0327)		AGGACTGGCAGGCGAGCGGGC	0.662000			T	EWSR1	Ewing sarcoma								3	10					0	0	1	0	0
CGREF1	10669	broad.mit.edu	37	2	27324395	27324395	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:27324395G>A	ENST00000402394.1	-	6	972	c.704C>T	c.(703-705)gCc>gTc	p.A235V	CGREF1_ENST00000405600.1_Missense_Mutation_p.A235V|CGREF1_ENST00000402550.1_Intron|CGREF1_ENST00000312734.4_Missense_Mutation_p.A235V|CGREF1_ENST00000260595.5_Missense_Mutation_p.A235V|CGREF1_ENST00000404694.3_Missense_Mutation_p.A357V|CGREF1_ENST00000452318.2_Intron	NM_006569.5	NP_006560.3	Q99674	CGRE1_HUMAN	cell growth regulator with EF-hand domain 1	235					cell adhesion|cell cycle arrest|negative regulation of cell proliferation|response to stress	extracellular region	calcium ion binding			kidney(1)|lung(4)|ovary(1)|prostate(2)|skin(1)|soft_tissue(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGGCCCAGGGGCATCTCCTTT	0.672000													90	232					0	0	1	0	0
RNF219	79596	broad.mit.edu	37	13	79213160	79213160	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:79213160T>C	ENST00000282003.6	-	4	405	c.347A>G	c.(346-348)aAa>aGa	p.K116R		NM_024546.3	NP_078822.3	Q5W0B1	RN219_HUMAN	ring finger protein 219	116							zinc ion binding			breast(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|liver(1)|lung(11)|prostate(1)|skin(1)	32		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.0414)		GCTGAGATTTTTACTCTTAAG	0.378000													43	35					0	0	1	0	0
OR10J1	26476	broad.mit.edu	37	1	159410499	159410499	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:159410499G>A	ENST00000423932.3	+	1	988	c.951G>A	c.(949-951)ggG>ggA	p.G317G	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	317					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity	p.G317G(1)		endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					CTGTTGGTGGGAAGTTTTCCT	0.488000													46	25					0	0	1	0	0
OR2T3	343173	broad.mit.edu	37	1	248636944	248636944	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:248636944C>T	ENST00000359594.2	+	1	318	c.293C>T	c.(292-294)tCc>tTc	p.S98F		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	98					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GATACCATTTCCCCGTCAGGC	0.542000													43	18					0	0	1	0	0
TMEM108	66000	broad.mit.edu	37	3	133098622	133098622	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:133098622G>A	ENST00000515826.1	+	3	190	c.67G>A	c.(67-69)Gaa>Aaa	p.E23K	TMEM108_ENST00000508711.1_Intron|TMEM108_ENST00000393130.3_Missense_Mutation_p.E23K|TMEM108_ENST00000321871.6_Missense_Mutation_p.E23K			Q6UXF1	TM108_HUMAN	transmembrane protein 108	23						integral to membrane				endometrium(3)|kidney(1)|large_intestine(5)|lung(22)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						GGCACTGACCGAAGCGCTGGC	0.552000													169	239					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30748522	30748522	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:30748522C>T	ENST00000262518.4	+	34	7546	c.7161C>T	c.(7159-7161)gcC>gcT	p.A2387A	SRCAP_ENST00000395059.2_Silent_p.A2325A|SRCAP_ENST00000344771.4_Silent_p.A2229A	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	2387					interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			AGGCCAAAGCCCCTGAGAGGC	0.637000													30	43					0	0	1	0	0
GRIK2	2898	broad.mit.edu	37	6	102307302	102307302	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:102307302G>A	ENST00000369138.1	+	10	1948	c.1458G>A	c.(1456-1458)ggG>ggA	p.G486G	GRIK2_ENST00000369137.3_Silent_p.G486G|GRIK2_ENST00000421544.1_Silent_p.G486G|GRIK2_ENST00000318991.6_Silent_p.G486G|GRIK2_ENST00000413795.1_Silent_p.G486G|GRIK2_ENST00000369134.4_Silent_p.G437G	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	486					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	TGGAAGATGGGAAATATGGAG	0.383000													15	49					0	0	1	0	0
HRG	3273	broad.mit.edu	37	3	186395022	186395022	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:186395022C>T	ENST00000232003.4	+	7	1008	c.928C>T	c.(928-930)Ccc>Tcc	p.P310S		NM_000412.2	NP_000403.1	P04196	HRG_HUMAN	histidine-rich glycoprotein	310	Pro-rich.				fibrinolysis|platelet activation|platelet degranulation	extracellular region|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(12)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0683)		CTCACATGGACCCCCACTTCC	0.512000													35	41					0	0	1	0	0
PHF21B	112885	broad.mit.edu	37	22	45312165	45312165	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:45312165T>C	ENST00000313237.5	-	4	709	c.559A>G	c.(559-561)Aac>Gac	p.N187D	PHF21B_ENST00000447824.3_Missense_Mutation_p.N175D|PHF21B_ENST00000403565.1_Missense_Mutation_p.N25D|PHF21B_ENST00000404079.2_Missense_Mutation_p.N175D|PHF21B_ENST00000396103.3_Missense_Mutation_p.N187D	NM_138415.4	NP_612424.1	Q96EK2	PF21B_HUMAN	PHD finger protein 21B	187							zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(14)|ovary(2)|prostate(1)|skin(2)	25		all_neural(38;0.00802)|Glioma(61;0.0353)|Ovarian(80;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0203)		CTCACCTTGTTGTCAGCACTG	0.622000													15	6					0	0	1	0	0
DOCK3	1795	broad.mit.edu	37	3	51246236	51246236	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:51246236C>T	ENST00000266037.9	+	13	1092	c.1069C>T	c.(1069-1071)Cac>Tac	p.H357Y		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	357						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GTCCCAGATCCACGAGAACAT	0.453000													7	6					0	0	1	0	0
FDXACB1	91893	broad.mit.edu	37	11	111746137	111746137	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:111746137T>C	ENST00000260257.4	-	5	1431	c.1384A>G	c.(1384-1386)Act>Gct	p.T462A	ALG9_ENST00000524880.1_Intron|ALG9_ENST00000527377.1_Intron|FDXACB1_ENST00000542429.1_Missense_Mutation_p.T313A	NM_138378.2	NP_612387.1	Q9BRP7	FDXA1_HUMAN	ferredoxin-fold anticodon binding domain containing 1	462					phenylalanyl-tRNA aminoacylation|tRNA processing		ATP binding|magnesium ion binding|phenylalanine-tRNA ligase activity|tRNA binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|upper_aerodigestive_tract(3)	19						AGATCCTCAGTACAATCTGGG	0.373000													30	31					0	0	1	0	0
COBL	23242	broad.mit.edu	37	7	51096460	51096460	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:51096460T>G	ENST00000395542.2	-	12	2763	c.2579A>C	c.(2578-2580)aAa>aCa	p.K860T	COBL_ENST00000265136.7_Missense_Mutation_p.K778T			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	778										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					GCCCAGGTGTTTTTCCACAGA	0.587000													3	46					0	0	1	0	0
FGF1	2246	broad.mit.edu	37	5	141974939	141974939	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:141974939C>T	ENST00000359370.6	-	4	463	c.384G>A	c.(382-384)aaG>aaA	p.K128K	AC005592.2_ENST00000443800.1_RNA|FGF1_ENST00000337706.2_Silent_p.K128K|FGF1_ENST00000494579.1_5'UTR|FGF1_ENST00000360966.5_3'UTR|FGF1_ENST00000407758.1_3'UTR|AC005592.2_ENST00000414314.1_RNA|FGF1_ENST00000378046.1_Silent_p.K128K|FGF1_ENST00000419524.2_Silent_p.K128K	NM_000800.4|NM_001144892.2|NM_001144934.1|NM_001144935.1|NM_001257205.1|NM_001257206.1|NM_001257207.1|NM_001257210.1|NM_001257212.1|NM_033137.2	NP_000791.1|NP_001138364.1|NP_001138406.1|NP_001138407.1|NP_001244134.1|NP_001244135.1|NP_001244136.1|NP_001244139.1|NP_001244141.1|NP_149128.1	P05230	FGF1_HUMAN	fibroblast growth factor 1 (acidic)	128	Heparin-binding.				angiogenesis|cellular response to heat|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cell migration|positive regulation of cholesterol biosynthetic process|positive regulation of intracellular protein kinase cascade|positive regulation of transcription from RNA polymerase II promoter	cell cortex|cytosol|extracellular space	fibroblast growth factor receptor binding|growth factor activity|heparin binding|S100 alpha binding			large_intestine(1)|lung(2)	3		all_neural(839;0.0416)|Ovarian(839;0.0955)|all_hematologic(541;0.1)|Prostate(461;0.157)|Lung NSC(810;0.21)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00032)	Pentosan Polysulfate(DB00686)	AGCTCCCATTCTTCTTGAGGC	0.468000													28	27					0	0	1	0	0
RIMS2	9699	broad.mit.edu	37	8	105263946	105263946	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:105263946C>T	ENST00000507740.1	+	22	3626	c.3390C>T	c.(3388-3390)ttC>ttT	p.F1130F	RIMS2_ENST00000339750.2_Silent_p.F252F|RIMS2_ENST00000406091.3_Silent_p.F1316F|RIMS2_ENST00000262231.10_Silent_p.F1155F|RIMS2_ENST00000436393.2_Silent_p.F1334F	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1378					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TCAAACTTTTCCCACCTTCCT	0.448000										HNSCC(12;0.0054)			49	93					0	0	1	0	0
LPAR3	23566	broad.mit.edu	37	1	85331549	85331549	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:85331549G>A	ENST00000440886.1	-	1	293	c.255C>T	c.(253-255)ttC>ttT	p.F85F	LPAR3_ENST00000491034.1_5'UTR|LPAR3_ENST00000370611.3_Silent_p.F85F			Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	85					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|urinary_tract(1)	24						TAAACATCAGGAATACATAGG	0.463000													32	180					0	0	1	0	0
IGHV3OR16-8	388255	broad.mit.edu	37	16	33020712	33020712	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:33020712C>T	ENST00000565407.2	+	0	120				RP11-19N8.2_ENST00000567619.1_RNA																							TGAGACTGTCCTGTCCAGCCT	0.577000													86	129					0	0	1	0	0
PON1	5444	broad.mit.edu	37	7	94931553	94931553	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:94931553G>A	ENST00000222381.3	-	8	1104	c.873C>T	c.(871-873)atC>atT	p.I291I	PON1_ENST00000542556.1_Silent_p.I291I	NM_000446.5	NP_000437.3	P27169	PON1_HUMAN	paraoxonase 1	291					aromatic compound catabolic process|carboxylic acid catabolic process|organophosphate catabolic process|phosphatidylcholine metabolic process|positive regulation of binding|positive regulation of cholesterol efflux|positive regulation of transporter activity|response to external stimulus	spherical high-density lipoprotein particle	aryldialkylphosphatase activity|arylesterase activity|calcium ion binding|phospholipid binding|protein homodimerization activity			autonomic_ganglia(1)|endometrium(2)|large_intestine(6)|lung(11)|pancreas(3)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	27	all_cancers(62;1.04e-10)|all_epithelial(64;3.67e-09)|Lung NSC(181;0.239)		STAD - Stomach adenocarcinoma(171;0.0031)		Atorvastatin(DB01076)|Cefazolin(DB01327)	CATAGAAGAAGATTTTCATGC	0.403000													17	27					0	0	1	0	0
CHRM2	1129	broad.mit.edu	37	7	136699707	136699707	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:136699707C>T	ENST00000445907.2	+	3	623	c.95C>T	c.(94-96)tCc>tTc	p.S32F	AC009264.1_ENST00000425981.2_RNA|AC009264.1_ENST00000439694.1_RNA|CHRM2_ENST00000320658.5_Missense_Mutation_p.S32F|AC009264.1_ENST00000593789.1_RNA|AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000597642.1_RNA|CHRM2_ENST00000397608.3_Missense_Mutation_p.S32F|AC009264.1_ENST00000598184.1_RNA|AC009264.1_ENST00000586239.1_RNA|CHRM2_ENST00000402486.3_Missense_Mutation_p.S32F|CHRM2_ENST00000401861.1_Missense_Mutation_p.S32F|CHRM2_ENST00000453373.1_Missense_Mutation_p.S32F	NM_001006627.1|NM_001006629.1	NP_001006628.1|NP_001006630.1	P08172	ACM2_HUMAN	cholinergic receptor, muscarinic 2	32					activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|nervous system development|regulation of heart contraction|response to virus	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(13)|liver(1)|lung(29)|ovary(4)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	68					Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Carbachol(DB00411)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Desipramine(DB01151)|Diphenidol(DB01231)|Doxacurium chloride(DB01135)|Doxacurium(DB01334)|Flavoxate(DB01148)|Gallamine Triethiodide(DB00483)|Homatropine Methylbromide(DB00725)|Hyoscyamine(DB00424)|Ipratropium(DB00332)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Metocurine(DB01336)|Mivacurium(DB01226)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Pilocarpine(DB01085)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Rocuronium(DB00728)|Thiethylperazine(DB00372)|Tolterodine(DB01036)|Tridihexethyl(DB00505)|Triflupromazine(DB00508)	GTGGCTGGATCCCTCAGTTTG	0.423000													31	67					0	0	1	0	0
LRRC7	57554	broad.mit.edu	37	1	70541968	70541968	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:70541968G>A	ENST00000310961.5	+	24	4617	c.4199G>A	c.(4198-4200)gGa>gAa	p.G1400E	LRRC7_ENST00000035383.5_Missense_Mutation_p.G1442E|LRRC7_ENST00000415775.2_Missense_Mutation_p.G726E			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	1442						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						AGTATGGATGGATATCCAGAG	0.463000													17	76					0	0	1	0	0
DCN	1634	broad.mit.edu	37	12	91552184	91552184	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:91552184C>T	ENST00000052754.5	-	4	928	c.427G>A	c.(427-429)Gaa>Aaa	p.E143K	DCN_ENST00000393155.1_Missense_Mutation_p.E143K|DCN_ENST00000425043.1_Intron|DCN_ENST00000228329.5_Intron|DCN_ENST00000303320.3_Intron|DCN_ENST00000547568.2_Intron|DCN_ENST00000552962.1_Missense_Mutation_p.E143K|DCN_ENST00000456569.2_Intron|DCN_ENST00000420120.2_Intron|DCN_ENST00000441303.2_Intron	NM_001920.3	NP_001911.1	P07585	PGS2_HUMAN	decorin	143					organ morphogenesis	extracellular space				central_nervous_system(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(8)|ovary(1)|skin(1)	20						TCTGGCAATTCCTTCAGCTGA	0.403000													26	56					0	0	1	0	0
AOC1	26	broad.mit.edu	37	7	150554586	150554586	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:150554586G>A	ENST00000493429.1	+	4	1612	c.1028G>A	c.(1027-1029)gGa>gAa	p.G343E	AOC1_ENST00000360937.4_Missense_Mutation_p.G343E|AOC1_ENST00000467291.1_Missense_Mutation_p.G343E|AOC1_ENST00000416793.2_Missense_Mutation_p.G343E					amine oxidase, copper containing 1																		CACTTCGGCGGAGAGCGCATT	0.632000													44	52					0	0	1	0	0
NRP2	8828	broad.mit.edu	37	2	206581035	206581035	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:206581035T>C	ENST00000360409.3	+	3	1161	c.370T>C	c.(370-372)Ttc>Ctc	p.F124L	NRP2_ENST00000540841.1_Missense_Mutation_p.F124L|NRP2_ENST00000412873.2_Missense_Mutation_p.F124L|NRP2_ENST00000417189.1_Missense_Mutation_p.F124L|NRP2_ENST00000357118.4_Missense_Mutation_p.F124L|NRP2_ENST00000540178.1_Missense_Mutation_p.F124L|NRP2_ENST00000355117.4_Missense_Mutation_p.F124L|NRP2_ENST00000272849.3_Missense_Mutation_p.F124L|NRP2_ENST00000357785.5_Missense_Mutation_p.F124L	NM_003872.2|NM_201266.1|NM_201279.1	NP_003863.2|NP_957718.1|NP_958436.1	O60462	NRP2_HUMAN	neuropilin 2	124	CUB 1.				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(14)|lung(19)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	52						CTACATCAGGTTCACCTCCGA	0.622000													47	50					0	0	1	0	0
EPPK1	83481	broad.mit.edu	37	8	144941602	144941602	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:144941602G>A	ENST00000525985.1	-	2	5891	c.5820C>T	c.(5818-5820)ctC>ctT	p.L1940L				P58107	EPIPL_HUMAN	epiplakin 1	1940						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			AGGGGTCCAGGAGGAACCCGG	0.642000													51	64					0	0	1	0	0
CTIF	9811	broad.mit.edu	37	18	46146020	46146020	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:46146020C>T	ENST00000256413.3	+	2	379	c.84C>T	c.(82-84)atC>atT	p.I28I	CTIF_ENST00000382998.4_Silent_p.I28I	NM_014772.2	NP_055587.1	O43310	CTIF_HUMAN	CBP80/20-dependent translation initiation factor	28	Interaction with NCBP1/CBP80.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of translational initiation	perinuclear region of cytoplasm	protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(14)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	31						AGCGCTTCATCGACAGCTACG	0.637000													3	10					0	0	1	0	0
CLVS1	157807	broad.mit.edu	37	8	62371063	62371063	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:62371063G>A	ENST00000519846.1	+	6	1411	c.939G>A	c.(937-939)tcG>tcA	p.S313S	CLVS1_ENST00000518592.1_Silent_p.S34S|CLVS1_ENST00000325897.4_Silent_p.S313S			Q8IUQ0	CLVS1_HUMAN	clavesin 1	313					lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			endometrium(3)|kidney(4)|large_intestine(4)|lung(21)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	41						ATACGTCCTCGAATCTGGAGA	0.493000													18	22					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45802416	45802416	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:45802416C>T	ENST00000357450.4	-	4	539	c.540G>A	c.(538-540)gaG>gaA	p.E180E	SMC1B_ENST00000404354.3_Silent_p.E180E	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	180					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		ACTGTGCATCCTCTTCGGCTT	0.368000													12	6					0	0	1	0	0
ST6GALNAC5	81849	broad.mit.edu	37	1	77528732	77528732	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:77528732C>T	ENST00000477717.1	+	5	1087	c.852C>T	c.(850-852)ctC>ctT	p.L284L		NM_030965.1	NP_112227.1	Q9BVH7	SIA7E_HUMAN	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	284					protein glycosylation	integral to Golgi membrane	sialyltransferase activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(5)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)	18						CAATGTACCTCTCCCATGAGC	0.423000													55	26					0	0	1	0	0
KCNT2	343450	broad.mit.edu	37	1	196395082	196395082	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:196395082C>T	ENST00000367433.5	-	11	1122	c.1021G>A	c.(1021-1023)Gat>Aat	p.D341N	KCNT2_ENST00000451324.2_Intron|KCNT2_ENST00000367431.4_Missense_Mutation_p.D341N|KCNT2_ENST00000294725.8_Missense_Mutation_p.D341N|KCNT2_ENST00000498426.1_5'UTR			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	341						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						ACCTGTACATCCATTTCAGTA	0.368000													9	55					0	0	1	0	0
MYEF2	50804	broad.mit.edu	37	15	48446052	48446052	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:48446052C>T	ENST00000324324.7	-	10	1303	c.1024G>A	c.(1024-1026)Gga>Aga	p.G342R	MYEF2_ENST00000267836.6_Missense_Mutation_p.G342R	NM_016132.3	NP_057216.2	Q9P2K5	MYEF2_HUMAN	myelin expression factor 2	342	Gly-rich.				transcription, DNA-dependent	Golgi apparatus|nucleus	DNA binding|nucleotide binding|RNA binding			endometrium(3)|kidney(1)|large_intestine(8)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	31		all_lung(180;0.00217)		all cancers(107;3.73e-10)|GBM - Glioblastoma multiforme(94;7.81e-07)		ATAGGCTGTCCACCCGGACCA	0.393000													11	18					0	0	1	0	0
RGS9	8787	broad.mit.edu	37	17	63149575	63149575	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:63149575G>A	ENST00000449996.3	+	2	165	c.93G>A	c.(91-93)gaG>gaA	p.E31E	RGS9_ENST00000443584.3_Silent_p.E31E|RGS9_ENST00000262406.9_Silent_p.E31E|RGS9_ENST00000577186.1_3'UTR	NM_001081955.2	NP_001075424.1	O75916	RGS9_HUMAN	regulator of G-protein signaling 9	31	DEP.				intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway|visual perception	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(8)|liver(2)|lung(12)|ovary(2)|prostate(3)|skin(3)	41						AGAACCCAGAGACAGGGGTCC	0.502000													54	102					0	0	1	0	0
GALNT9	50614	broad.mit.edu	37	12	132685754	132685754	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:132685754C>T	ENST00000328957.8	-	8	1315	c.1316G>A	c.(1315-1317)aGg>aAg	p.R439K	GALNT9_ENST00000397325.2_Missense_Mutation_p.R73K|GALNT9_ENST00000541995.1_Missense_Mutation_p.R73K|GALNT9_ENST00000535228.1_Missense_Mutation_p.R190K	NM_001122636.1	NP_001116108.1	Q9HCQ5	GALT9_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 9 (GalNAc-T9)	439					protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)|endometrium(1)|large_intestine(2)|lung(5)	9	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.49e-08)|Epithelial(86;3.55e-07)|all cancers(50;2.09e-05)		ACACTTCAGCCTCTGACGCAG	0.597000													4	26					0	0	1	0	0
EYA4	2070	broad.mit.edu	37	6	133783826	133783826	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:133783826G>A	ENST00000367895.5	+	9	1112	c.648G>A	c.(646-648)caG>caA	p.Q216Q	EYA4_ENST00000452339.2_Silent_p.Q162Q|EYA4_ENST00000431403.2_Silent_p.Q216Q|EYA4_ENST00000355167.3_Silent_p.Q216Q|EYA4_ENST00000355286.6_Silent_p.Q193Q|EYA4_ENST00000531901.1_Silent_p.Q216Q|EYA4_ENST00000525849.1_Silent_p.Q193Q|EYA4_ENST00000430974.2_Silent_p.Q162Q	NM_004100.4	NP_004091.3	O95677	EYA4_HUMAN	eyes absent homolog 4 (Drosophila)	216					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(3)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|skin(1)	48	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		CCCCATTACAGAGTGGCTGCC	0.463000													9	50					0	0	1	0	0
TBC1D9B	23061	broad.mit.edu	37	5	179305440	179305440	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:179305440C>T	ENST00000356834.3	-	10	1688	c.1651G>A	c.(1651-1653)Gag>Aag	p.E551K	TBC1D9B_ENST00000355235.3_Missense_Mutation_p.E551K	NM_198868.2	NP_942568.2	Q66K14	TBC9B_HUMAN	TBC1 domain family, member 9B (with GRAM domain)	551	Rab-GAP TBC.					integral to membrane|intracellular	calcium ion binding|Rab GTPase activator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	28	all_cancers(89;0.000197)|all_epithelial(37;6.84e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0236)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TCGATCTCCTCTGTGGCCAGG	0.642000													5	6					0	0	1	0	0
TROAP	10024	broad.mit.edu	37	12	49724538	49724538	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:49724538C>T	ENST00000551245.1	+	13	2021	c.1910C>T	c.(1909-1911)cCt>cTt	p.P637L	TROAP_ENST00000257909.3_Missense_Mutation_p.P637L|TROAP_ENST00000547923.1_Missense_Mutation_p.P316L			Q12815	TROAP_HUMAN	trophinin associated protein	637	4 X 33 AA approximate tandem repeats.|Cys-rich.				cell adhesion	cytoplasm				breast(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	32						GGGCCCTGCCCTAGGGTAGAG	0.652000													14	66					0	0	1	0	0
NUAK1	9891	broad.mit.edu	37	12	106480593	106480593	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:106480593G>A	ENST00000261402.2	-	3	1811	c.432C>T	c.(430-432)atC>atT	p.I144I		NM_014840.2	NP_055655.1	O60285	NUAK1_HUMAN	NUAK family, SNF1-like kinase, 1	144	Protein kinase.						ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	37						GCCGCTCACTGATGTAATCGT	0.512000													16	51					0	0	1	0	0
CDC42BPA	8476	broad.mit.edu	37	1	227198755	227198755	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:227198755G>A	ENST00000334218.5	-	34	5704	c.4762C>T	c.(4762-4764)Cct>Tct	p.P1588S	CDC42BPA_ENST00000366764.2_Intron|CDC42BPA_ENST00000366765.3_Intron|CDC42BPA_ENST00000535525.1_Intron|CDC42BPA_ENST00000366767.3_Intron|CDC42BPA_ENST00000366769.3_Intron|CDC42BPA_ENST00000366766.2_Intron			Q5VT25	MRCKA_HUMAN	CDC42 binding protein kinase alpha (DMPK-like)	1601					actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|cervix(1)|endometrium(8)|kidney(8)|large_intestine(12)|lung(32)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|urinary_tract(2)	77		all_cancers(173;0.156)|Prostate(94;0.0792)				GATGGATAAGGGAAACCTGGC	0.378000													4	6					0	0	1	0	0
DPPA2	151871	broad.mit.edu	37	3	109027927	109027927	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:109027927C>T	ENST00000478945.1	-	5	589		c.e5-1			NM_138815.3	NP_620170.3	Q7Z7J5	DPPA2_HUMAN	developmental pluripotency associated 2							nucleus	nucleic acid binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CTTCGATTTTCTTAGGAAATG	0.408000													74	123					0	0	1	0	0
COL2A1	1280	broad.mit.edu	37	12	48367985	48367985	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:48367985C>T	ENST00000380518.3	-	53	4368	c.4204G>A	c.(4204-4206)Gaa>Aaa	p.E1402K	COL2A1_ENST00000337299.6_Missense_Mutation_p.E1333K|COL2A1_ENST00000493991.1_5'UTR	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	1402	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	CCAGCTGCTTCGTCCAGATAG	0.567000													30	31					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34101636	34101636	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:34101636G>A	ENST00000297161.2	+	12	1429	c.1055G>A	c.(1054-1056)gGa>gAa	p.G352E	BMPER_ENST00000426693.1_Missense_Mutation_p.G352E	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	352	VWFC 5.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						AACAGAAAAGGATGCTGTCCT	0.303000													5	13					0	0	1	0	0
GUSBP3	653188	broad.mit.edu	37	5	68902941	68902941	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:68902941C>T	ENST00000510264.2	+	0	16																											CTCACTGCTTCCTACTAAAGG	0.403000													25	186					0	0	1	0	0
SLIT3	6586	broad.mit.edu	37	5	168233482	168233482	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:168233482G>A	ENST00000519560.1	-	9	1323	c.904C>T	c.(904-906)Cct>Tct	p.P302S	SLIT3_ENST00000332966.8_Missense_Mutation_p.P302S|SLIT3_ENST00000404867.3_Missense_Mutation_p.P302S	NM_001271946.1|NM_003062.2	NP_001258875.1|NP_003053.1	O75094	SLIT3_HUMAN	slit homolog 3 (Drosophila)	302	LRRNT 2.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(15)|liver(2)|lung(48)|ovary(4)|prostate(7)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	100	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AAGTTGGCAGGAATCTCCATC	0.577000													53	46					0	0	1	0	0
HS3ST5	222537	broad.mit.edu	37	6	114378856	114378856	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:114378856C>T	ENST00000312719.5	-	5	1794	c.606G>A	c.(604-606)agG>agA	p.R202R	RP3-399L15.3_ENST00000523087.1_RNA|RP3-399L15.3_ENST00000519104.1_RNA|RP3-399L15.3_ENST00000519270.1_RNA|HS3ST5_ENST00000411826.1_Silent_p.R202R			Q8IZT8	HS3S5_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 5	202					heparan sulfate proteoglycan biosynthetic process, enzymatic modification|negative regulation of coagulation|protein sulfation|regulation of virion penetration into host cell	Golgi membrane|integral to membrane	3'-phosphoadenosine 5'-phosphosulfate binding|[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity|protein binding			breast(4)|endometrium(2)|kidney(1)|large_intestine(7)|lung(17)|ovary(1)|pancreas(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	41		all_cancers(87;0.0587)|Colorectal(196;0.0676)|all_epithelial(87;0.154)		OV - Ovarian serous cystadenocarcinoma(136;0.00937)|all cancers(137;0.0117)|Epithelial(106;0.0274)|GBM - Glioblastoma multiforme(226;0.143)		TTTTGTTCTTCCTCTCCTTCC	0.403000													65	163					0	0	1	0	0
DRP2	1821	broad.mit.edu	37	X	100497448	100497448	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:100497448G>A	ENST00000395209.3	+	8	1490	c.963G>A	c.(961-963)tgG>tgA	p.W321*	DRP2_ENST00000402866.1_Nonsense_Mutation_p.W321*|DRP2_ENST00000541709.1_Nonsense_Mutation_p.W243*|DRP2_ENST00000538510.1_Nonsense_Mutation_p.W321*	NM_001939.2	NP_001930.2	Q13474	DRP2_HUMAN	dystrophin related protein 2	321					central nervous system development	cytoplasm|cytoskeleton	zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	31						ACGTCCGATGGAAACAACTAC	0.493000													66	14					0	0	1	0	0
ADAM28	10863	broad.mit.edu	37	8	24167676	24167676	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:24167676G>A	ENST00000265769.4	+	4	338	c.227_splice	c.e4-1	p.K76_splice	ADAM28_ENST00000397649.3_5'UTR|RP11-624C23.1_ENST00000518988.1_RNA|RP11-624C23.1_ENST00000523578.1_RNA|RP11-624C23.1_ENST00000523700.1_RNA|ADAM28_ENST00000437154.2_Splice_Site_p.K76_splice|RP11-624C23.1_ENST00000519689.1_RNA|ADAM28_ENST00000540823.1_5'UTR	NM_014265.4	NP_055080.2	Q9UKQ2	ADA28_HUMAN	ADAM metallopeptidase domain 28	76					proteolysis|spermatogenesis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(7)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Prostate(55;0.0959)		Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0434)|BRCA - Breast invasive adenocarcinoma(99;0.175)		CTTTCTCCAGGAACCTCCTTG	0.413000													10	21					0	0	1	0	0
LSP1	4046	broad.mit.edu	37	11	1874426	1874426	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:1874426G>A	ENST00000311604.3	+	1	227	c.53_splice	c.e1+1	p.G18_splice		NM_002339.2	NP_002330.1	P33241	LSP1_HUMAN	lymphocyte-specific protein 1	18					cellular component movement|cellular defense response	actin cytoskeleton|Golgi apparatus|plasma membrane	actin binding|signal transducer activity			haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(9)|prostate(1)|skin(1)	16		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|Lung(200;0.0729)|LUSC - Lung squamous cell carcinoma(625;0.0856)		AGAGTTGCTGGGGTAAGGGTC	0.667000													10	20					0	0	1	0	0
TICRR	90381	broad.mit.edu	37	15	90144983	90144983	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:90144983C>T	ENST00000268138.7	+	12	2448	c.2343C>T	c.(2341-2343)atC>atT	p.I781I	TICRR_ENST00000560985.1_Silent_p.I780I					TOPBP1-interacting checkpoint and replication regulator																		TTGACTCTATCCCAAAGACAC	0.438000													38	82					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518733	113518733	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:113518733G>A	ENST00000284601.3	-	4	2482	c.2414C>T	c.(2413-2415)tCa>tTa	p.S805L		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	805					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						ACCTAAACGTGATTCCTTTTC	0.383000													26	40					0	0	1	0	0
FAM47A	158724	broad.mit.edu	37	X	34148955	34148955	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:34148955C>T	ENST00000346193.3	-	1	1492	c.1441G>A	c.(1441-1443)Gaa>Aaa	p.E481K		NM_203408.3	NP_981953.2	Q5JRC9	FA47A_HUMAN	family with sequence similarity 47, member A	481										NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(1)|endometrium(9)|kidney(5)|large_intestine(17)|lung(44)|ovary(5)|prostate(2)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	97						TTGGGATGTTCCGGGTGGGGA	0.622000													39	10					0	0	1	0	0
DOCK7	85440	broad.mit.edu	37	1	63119728	63119728	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:63119728G>A	ENST00000251157.5	-	3	280	c.247C>T	c.(247-249)Cct>Tct	p.P83S	DOCK7_ENST00000340370.5_Missense_Mutation_p.P83S|DOCK7_ENST00000404627.2_Missense_Mutation_p.P83S	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	83					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						TCATCTGGAGGAAATTCAATC	0.433000													12	61					0	0	1	0	0
STC2	8614	broad.mit.edu	37	5	172750363	172750363	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:172750363C>T	ENST00000265087.4	-	3	1674	c.365G>A	c.(364-366)aGc>aAc	p.S122N	STC2_ENST00000520593.1_5'UTR	NM_003714.2	NP_003705.1	O76061	STC2_HUMAN	stanniocalcin 2	122					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|skin(3)	25	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GCACTTCCGGCTTATGCAGCC	0.607000													11	13					0	0	1	0	0
ITPR1	3708	broad.mit.edu	37	3	4859775	4859775	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:4859775G>A	ENST00000302640.8	+	59	8182	c.7832G>A	c.(7831-7833)aGa>aAa	p.R2611K	AC018816.3_ENST00000489771.1_Intron|AC018816.3_ENST00000449914.1_Intron|ITPR1_ENST00000357086.4_Missense_Mutation_p.R2578K|ITPR1_ENST00000544951.1_Missense_Mutation_p.R589K|ITPR1_ENST00000354582.6_Missense_Mutation_p.R2611K|AC018816.3_ENST00000441894.1_Intron|ITPR1_ENST00000463980.1_3'UTR|ITPR1_ENST00000456211.2_Missense_Mutation_p.R2563K|ITPR1_ENST00000443694.2_Missense_Mutation_p.R2611K|ITPR1_ENST00000423119.2_Missense_Mutation_p.R2578K	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2626					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GGCTTGGAAAGAGACAAGTTT	0.438000													6	11					0	0	1	0	0
PRLR	5618	broad.mit.edu	37	5	35065776	35065776	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:35065776G>A	ENST00000382002.5	-	10	1710	c.1284C>T	c.(1282-1284)tcC>tcT	p.S428S	PRLR_ENST00000542609.1_Intron|PRLR_ENST00000397391.3_Intron|PRLR_ENST00000348262.3_Intron|PRLR_ENST00000342362.5_Silent_p.S327S|PRLR_ENST00000513753.1_Intron|PRLR_ENST00000511486.1_Silent_p.S327S|PRLR_ENST00000310101.5_Intron|PRLR_ENST00000231423.3_Intron	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	428					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	TGTGGTAAGAGGATCTGGGGT	0.493000													43	146					0	0	1	0	0
KRT19	3880	broad.mit.edu	37	17	39684155	39684155	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:39684155C>T	ENST00000361566.3	-	1	405	c.345G>A	c.(343-345)tgG>tgA	p.W115*		NM_002276.4	NP_002267.2			keratin 19											breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	12		Breast(137;0.00038)				GCTTCTGGTACCAGTCGCGGA	0.667000													42	69					0	0	1	0	0
ABCC11	85320	broad.mit.edu	37	16	48201473	48201473	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:48201473G>A	ENST00000394747.1	-	28	4339	c.3990C>T	c.(3988-3990)ctC>ctT	p.L1330L	ABCC11_ENST00000394748.1_Silent_p.L1330L|ABCC11_ENST00000565329.1_5'UTR|ABCC11_ENST00000356608.2_Silent_p.L1330L|ABCC11_ENST00000353782.5_Silent_p.L1292L	NM_033151.3	NP_149163.2	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 11	1330	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(42)|ovary(3)|prostate(2)|skin(5)|urinary_tract(2)	83		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				GGGCAATGACGAGCACGGTGC	0.567000													43	51					0	0	1	0	0
OR1E2	8388	broad.mit.edu	37	17	3336433	3336433	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:3336433G>A	ENST00000248384.1	-	1	702	c.703C>T	c.(703-705)Ctc>Ttc	p.L235F		NM_003554.1	NP_003545.1	P47887	OR1E2_HUMAN	olfactory receptor, family 1, subfamily E, member 2	235					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(3)|lung(3)	9						GGGACCTTGAGGATGGAGGAG	0.473000													12	8					0	0	1	0	0
KLRK1	22914	broad.mit.edu	37	12	10532349	10532349	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:10532349C>T	ENST00000240618.6	-	4	331	c.191G>A	c.(190-192)gGa>gAa	p.G64E	RP11-277P12.20_ENST00000500682.1_RNA|KLRC4-KLRK1_ENST00000539300.1_3'UTR|KLRK1_ENST00000540818.1_Missense_Mutation_p.G64E	NM_001199805.1|NM_007360.3	NP_001186734.1|NP_031386.2	P26718	NKG2D_HUMAN	killer cell lectin-like receptor subfamily K, member 1	64					natural killer cell activation|T cell costimulation	integral to plasma membrane	sugar binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)	9						GAAACGGATTCCCATGGCTAC	0.363000													15	9					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168100015	168100015	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:168100015G>A	ENST00000409195.1	+	9	2202	c.2113G>A	c.(2113-2115)Gga>Aga	p.G705R	XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000295237.9_Missense_Mutation_p.G705R|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409273.1_Missense_Mutation_p.G483R|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409756.2_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	530					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AGATCAACTTGGACAGCTTCA	0.383000													44	60					0	0	1	0	0
SNCAIP	9627	broad.mit.edu	37	5	121759418	121759418	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:121759418G>A	ENST00000261367.7	+	6	2555	c.1127G>A	c.(1126-1128)gGa>gAa	p.G376E	SNCAIP_ENST00000542191.1_Intron|SNCAIP_ENST00000379533.2_Missense_Mutation_p.G376E|SNCAIP_ENST00000504884.2_Intron|SNCAIP_ENST00000379538.3_Intron|SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000379536.2_Missense_Mutation_p.G329E|SNCAIP_ENST00000261368.8_Missense_Mutation_p.G329E|SNCAIP_ENST00000503116.2_Missense_Mutation_p.G376E			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	329					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		GTTAAAGAAGGACAGATCTCT	0.413000													12	52					0	0	1	0	0
LPHN3	23284	broad.mit.edu	37	4	62813844	62813844	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:62813844C>T	ENST00000512091.1	+	16	3198	c.2451C>T	c.(2449-2451)aaC>aaT	p.N817N	LPHN3_ENST00000508693.1_Silent_p.N885N|LPHN3_ENST00000508946.1_Silent_p.N817N|LPHN3_ENST00000514996.1_Silent_p.N817N|LPHN3_ENST00000514591.1_Silent_p.N817N|LPHN3_ENST00000507164.1_Silent_p.N885N|LPHN3_ENST00000506746.1_Silent_p.N885N|LPHN3_ENST00000506720.1_Silent_p.N885N|LPHN3_ENST00000509896.1_Silent_p.N885N|LPHN3_ENST00000545650.1_Silent_p.N817N|LPHN3_ENST00000511324.1_Silent_p.N885N|LPHN3_ENST00000504896.1_Silent_p.N817N|LPHN3_ENST00000514157.1_Silent_p.N817N|LPHN3_ENST00000507625.1_Silent_p.N885N|LPHN3_ENST00000506700.1_Silent_p.N817N			Q9HAR2	LPHN3_HUMAN	latrophilin 3	804	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						TCAACCCTAACTGTTCATTTT	0.378000													10	14					0	0	1	0	0
FSTL5	56884	broad.mit.edu	37	4	162307132	162307132	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:162307132G>A	ENST00000306100.5	-	16	2747	c.2311C>T	c.(2311-2313)Ctc>Ttc	p.L771F	FSTL5_ENST00000379164.4_Missense_Mutation_p.L770F|RP11-234O6.2_ENST00000508189.1_RNA|FSTL5_ENST00000427802.2_Missense_Mutation_p.L761F|FSTL5_ENST00000536695.1_Missense_Mutation_p.L770F	NM_001128427.2|NM_020116.4	NP_001121899.1|NP_064501.2	Q8N475	FSTL5_HUMAN	follistatin-like 5	771						extracellular region	calcium ion binding			central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(18)|lung(43)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	91	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CCAGAAGAGAGCTCCACAAAG	0.458000													59	25					0	0	1	0	0
CXCR2	3579	broad.mit.edu	37	2	218999717	218999717	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:218999717G>A	ENST00000318507.2	+	3	620	c.193G>A	c.(193-195)Gga>Aga	p.G65R		NM_001557.3	NP_001548.1	P25025	CXCR2_HUMAN	chemokine (C-X-C motif) receptor 2	65					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular defense response|dendritic cell chemotaxis|inflammatory response|neutrophil activation|neutrophil chemotaxis|positive regulation of cell proliferation	cell surface|integral to plasma membrane|mast cell granule	interleukin-8 receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(11)|skin(1)|stomach(1)	22						GAGCCTGCTGGGAAACTCCCT	0.512000													39	102					0	0	1	0	0
ERBB2IP	55914	broad.mit.edu	37	5	65319138	65319138	+	Silent	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:65319138A>T	ENST00000284037.5	+	9	1007	c.618A>T	c.(616-618)ctA>ctT	p.L206L	ERBB2IP_ENST00000380935.1_Silent_p.L206L|ERBB2IP_ENST00000380939.2_Silent_p.L206L|ERBB2IP_ENST00000416865.2_Silent_p.L206L|ERBB2IP_ENST00000511297.1_Silent_p.L206L|ERBB2IP_ENST00000380936.1_Silent_p.L206L|ERBB2IP_ENST00000508515.1_Silent_p.L206L|ERBB2IP_ENST00000380938.2_Silent_p.L206L|ERBB2IP_ENST00000506030.1_Silent_p.L206L|ERBB2IP_ENST00000380943.2_Silent_p.L206L	NM_001253697.1	NP_001240626.1	Q96RT1	LAP2_HUMAN	erbb2 interacting protein	206					basal protein localization|cell adhesion|cell cycle|cell growth|epidermal growth factor receptor signaling pathway|establishment or maintenance of epithelial cell apical/basal polarity|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization	basement membrane|cytoplasm|hemidesmosome|nucleus	ErbB-2 class receptor binding|integrin binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(8)|lung(11)|ovary(3)|skin(2)	36		Lung NSC(167;9.45e-06)|Prostate(74;0.0139)|Ovarian(174;0.0547)|Breast(144;0.093)|Colorectal(97;0.234)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0767)|Lung(70;0.00191)		TTGAGCAACTAAGTGGATTGA	0.383000													33	33					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74627332	74627332	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:74627332G>A	ENST00000321288.5	+	21	2753	c.2753G>A	c.(2752-2754)cGa>cAa	p.R918Q	CCDC33_ENST00000398814.3_Missense_Mutation_p.R681Q|CCDC33_ENST00000268082.4_Missense_Mutation_p.R308Q|CCDC33_ENST00000558821.1_Missense_Mutation_p.R274Q			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	884							protein binding			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						GACTCAGCTCGACGCTGGGGA	0.577000													19	49					0	0	1	0	0
CARF	79800	broad.mit.edu	37	2	203826218	203826218	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:203826218C>T	ENST00000444724.1	+	8	1181	c.901C>T	c.(901-903)Cct>Tct	p.P301S	CARF_ENST00000438828.2_Intron|CARF_ENST00000434998.1_Missense_Mutation_p.P199S|WDR12_ENST00000477723.1_Intron|CARF_ENST00000320443.8_Intron|CARF_ENST00000428585.1_Intron|CARF_ENST00000456821.2_Intron|CARF_ENST00000545262.1_Intron|CARF_ENST00000545253.1_Intron|CARF_ENST00000471271.1_Intron|CARF_ENST00000402905.2_Intron|CARF_ENST00000414439.1_Intron					calcium responsive transcription factor																		ATGTGATTTTCCTAAGGTGAT	0.269000													3	1					0	0	1	0	0
OR1A1	8383	broad.mit.edu	37	17	3119592	3119592	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:3119592G>A	ENST00000304094.1	+	1	678	c.678G>A	c.(676-678)caG>caA	p.Q226Q		NM_014565.2	NP_055380.2	Q9P1Q5	OR1A1_HUMAN	olfactory receptor, family 1, subfamily A, member 1	226					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.Q226Q(1)		NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	23						CAGTCTTCCAGGTTCCTTCCA	0.478000													71	38					0	0	1	0	0
SH2B1	25970	broad.mit.edu	37	16	28884917	28884917	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:28884917G>A	ENST00000322610.8	+	11	2486	c.2047G>A	c.(2047-2049)Gcg>Acg	p.A683T	SH2B1_ENST00000538342.1_3'UTR|SH2B1_ENST00000337120.5_3'UTR|SH2B1_ENST00000563674.1_3'UTR|SH2B1_ENST00000545570.1_3'UTR|SH2B1_ENST00000359285.5_3'UTR|SH2B1_ENST00000395532.4_3'UTR			Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1	683					blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25						GAAAGAGAAAGCGGGCGGTGG	0.657000													2	0					0	0	1	0	0
KIF13B	23303	broad.mit.edu	37	8	28974478	28974478	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:28974478T>C	ENST00000524189.1	-	31	3745	c.3707A>G	c.(3706-3708)cAg>cGg	p.Q1236R	CTD-2647L4.1_ENST00000523661.1_RNA	NM_015254.3	NP_056069.2	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	1236					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding			endometrium(6)|kidney(1)|lung(20)|urinary_tract(1)	28		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		CCTGCTGAGCTGAGGGCAGCC	0.582000													41	57					0	0	1	0	0
MYH7	4625	broad.mit.edu	37	14	23896804	23896804	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:23896804C>T	ENST00000355349.3	-	16	2040	c.1878G>A	c.(1876-1878)ggG>ggA	p.G626G		NM_000257.2	NP_000248.2	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	626	Myosin head-like.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(3)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(19)|lung(57)|ovary(5)|prostate(9)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	137	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GCGCATCAGCCCCAGCATAGT	0.542000													25	6					0	0	1	0	0
CEP89	84902	broad.mit.edu	37	19	33457303	33457303	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:33457303G>A	ENST00000305768.4	-	2	197	c.109C>T	c.(109-111)Cct>Tct	p.P37S	CEP89_ENST00000590597.1_Missense_Mutation_p.P37S	NM_032816.3	NP_116205.3	Q96ST8	CEP89_HUMAN	centrosomal protein 89kDa	37						centrosome|spindle pole				breast(2)|cervix(1)|endometrium(4)|large_intestine(4)|lung(15)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	35						CTGCGGGGAGGAGGTGTGCGT	0.557000													17	24					0	0	1	0	0
CCDC33	80125	broad.mit.edu	37	15	74574143	74574143	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:74574143G>A	ENST00000321288.5	+	12	1657	c.1657G>A	c.(1657-1659)Gat>Aat	p.D553N	CCDC33_ENST00000398814.3_Missense_Mutation_p.D350N			Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33	553							protein binding	p.D553N(1)|p.D350N(1)		breast(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(2)|lung(17)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	39						AACTATCAATGATGAGGCCCC	0.592000													53	42					0	0	1	0	0
EIF4G3	8672	broad.mit.edu	37	1	21177808	21177808	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:21177808C>T	ENST00000602326.1	-	26	4148	c.3565G>A	c.(3565-3567)Ggt>Agt	p.G1189S	EIF4G3_ENST00000536266.1_Missense_Mutation_p.G787S|EIF4G3_ENST00000374937.3_Missense_Mutation_p.G1189S|EIF4G3_ENST00000264211.8_Missense_Mutation_p.G1183S|EIF4G3_ENST00000537738.1_Missense_Mutation_p.G673S|EIF4G3_ENST00000374935.3_Missense_Mutation_p.G903S|EIF4G3_ENST00000400422.1_Missense_Mutation_p.G1183S	NM_001198802.1	NP_001185731.1	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4 gamma, 3	1183					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(18)|lung(20)|ovary(1)|prostate(4)|skin(3)|stomach(1)|urinary_tract(3)	70		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		ACATCCACACCTCCTGTGAGC	0.488000													30	126					0	0	1	0	0
OR8U1	219417	broad.mit.edu	37	11	56143765	56143765	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:56143765T>G	ENST00000302270.1	+	1	666	c.666T>G	c.(664-666)atT>atG	p.I222M		NM_001005204.1	NP_001005204.1			olfactory receptor, family 8, subfamily U, member 1											NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(23)|ovary(4)|skin(1)|stomach(1)	39	Esophageal squamous(21;0.00448)					TGTTCATCATTTCTGCCATCC	0.488000													39	50					0	0	1	0	0
TECRL	253017	broad.mit.edu	37	4	65155440	65155440	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:65155440G>A	ENST00000381210.3	-	9	930	c.820C>T	c.(820-822)Ccc>Tcc	p.P274S	TECRL_ENST00000507440.1_Missense_Mutation_p.P274S	NM_001010874.4	NP_001010874.2	Q5HYJ1	TECRL_HUMAN	trans-2,3-enoyl-CoA reductase-like	274					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors			endometrium(2)|kidney(5)|large_intestine(7)|lung(30)|prostate(1)|skin(1)|stomach(1)	47						GTGTGATTGGGATGAGACAAC	0.274000													3	18					0	0	1	0	0
KCNC2	3747	broad.mit.edu	37	12	75434918	75434918	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:75434918C>T	ENST00000341669.3	-	5	2392	c.1849G>A	c.(1849-1851)Gac>Aac	p.D617N	KCNC2_ENST00000350228.2_3'UTR|KCNC2_ENST00000549446.1_3'UTR|RP11-81K13.1_ENST00000549762.1_RNA|RP11-81K13.1_ENST00000550049.1_RNA|KCNC2_ENST00000548513.1_3'UTR|RP11-81K13.1_ENST00000547040.1_RNA|KCNC2_ENST00000550433.1_Missense_Mutation_p.D617N|KCNC2_ENST00000298972.1_3'UTR	NM_001260498.1	NP_001247427.1	Q96PR1	KCNC2_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 2	0					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(3)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(28)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	54						CCAGTATAGTCCTTGGTATGG	0.443000													10	23					0	0	1	0	0
PCDHB10	56126	broad.mit.edu	37	5	140574328	140574328	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140574328C>T	ENST00000239446.4	+	1	2387	c.2203C>T	c.(2203-2205)Cca>Tca	p.P735S		NM_018930.3	NP_061753.1	Q9UN67	PCDBA_HUMAN		735					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GGGTCCTTTTCCAGGGCATCT	0.657000													46	87					0	0	1	0	0
BBX	56987	broad.mit.edu	37	3	107492197	107492197	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:107492197C>T	ENST00000415149.2	+	11	1956	c.1629C>T	c.(1627-1629)tcC>tcT	p.S543S	BBX_ENST00000402543.1_Silent_p.S543S|BBX_ENST00000416476.2_Intron|BBX_ENST00000406780.1_Silent_p.S543S|BBX_ENST00000325805.8_Silent_p.S543S	NM_001142568.1|NM_020235.5	NP_001136040.1|NP_064620.2	Q8WY36	BBX_HUMAN	bobby sox homolog (Drosophila)	543					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding	p.S543S(1)		breast(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(18)|ovary(4)|pancreas(1)|skin(2)	49			OV - Ovarian serous cystadenocarcinoma(3;0.112)			AGGAGAAATCCTCAGACACCA	0.428000													25	39					0	0	1	0	0
CD109	135228	broad.mit.edu	37	6	74491024	74491024	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:74491024G>A	ENST00000437994.2	+	17	2376	c.1945G>A	c.(1945-1947)Gat>Aat	p.D649N	CD109_ENST00000422508.2_Missense_Mutation_p.D572N|CD109_ENST00000287097.5_Missense_Mutation_p.D649N	NM_001159587.1|NM_133493.3	NP_001153059.1|NP_598000.2	Q6YHK3	CD109_HUMAN	CD109 molecule	649	Bait region (approximate) (By similarity).					anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			NS(2)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CCTCACGAAGGATTATATTGA	0.294000													8	16					0	0	1	0	0
OR8B3	390271	broad.mit.edu	37	11	124267062	124267062	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:124267062G>A	ENST00000354597.3	-	1	202	c.186C>T	c.(184-186)ttC>ttT	p.F62F		NM_001005467.1	NP_001005467.1	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B, member 3	62					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		GATTGAAGAGGAAATAGTACA	0.383000													31	71					0	0	1	0	0
TGFBR3	7049	broad.mit.edu	37	1	92185652	92185652	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:92185652G>A	ENST00000212355.4	-	9	1676	c.1211C>T	c.(1210-1212)cCt>cTt	p.P404L	TGFBR3_ENST00000370399.2_Missense_Mutation_p.P403L|TGFBR3_ENST00000525962.1_Missense_Mutation_p.P404L	NM_001195683.1|NM_003243.4	NP_001182612.1|NP_003234.2	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	404					BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(24)|ovary(3)|prostate(4)|skin(1)|stomach(1)|urinary_tract(3)	55		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		ATCTGGGAAAGGAAACGGAAG	0.587000													17	60					0	0	1	0	0
DDX60L	91351	broad.mit.edu	37	4	169362491	169362491	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:169362491G>A	ENST00000511577.1	-	10	1538	c.1291C>T	c.(1291-1293)Caa>Taa	p.Q431*	DDX60L_ENST00000260184.7_Nonsense_Mutation_p.Q431*|DDX60L_ENST00000505890.1_Nonsense_Mutation_p.Q431*			Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	431							ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		TTAGTACCTTGAATGACCGAT	0.333000													9	52					0	0	1	0	0
MLIP	90523	broad.mit.edu	37	6	53986346	53986346	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:53986346C>T	ENST00000514921.1	+	2	278	c.165C>T	c.(163-165)ttC>ttT	p.F55F	MLIP_ENST00000511744.1_3'UTR|MLIP_ENST00000509997.1_Intron|MLIP_ENST00000358276.5_Silent_p.F49F|MLIP_ENST00000502396.1_Silent_p.F66F|MLIP_ENST00000370877.2_Intron|MLIP_ENST00000274897.5_Silent_p.F55F|MLIP_ENST00000370876.2_Intron			Q5VWP3	MLIP_HUMAN	muscular LMNA-interacting protein	55						nuclear envelope|PML body	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(16)|ovary(8)|skin(4)|stomach(1)|urinary_tract(1)	34						CCTCTAAATTCCTTGTTAAAA	0.358000													30	41					0	0	1	0	0
VIL1	7429	broad.mit.edu	37	2	219294109	219294109	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:219294109G>A	ENST00000248444.5	+	7	757	c.669G>A	c.(667-669)atG>atA	p.M223I	VIL1_ENST00000440053.1_Missense_Mutation_p.M223I|VIL1_ENST00000392114.2_Intron	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	223	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGAAGCTGATGGAGGTGATGA	0.627000													35	72					0	0	1	0	0
SERPINB10	5273	broad.mit.edu	37	18	61587099	61587099	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:61587099C>T	ENST00000238508.3	+	5	509	c.450C>T	c.(448-450)atC>atT	p.I150I		NM_005024.1	NP_005015.1			serpin peptidase inhibitor, clade B (ovalbumin), member 10											breast(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(6)|prostate(1)|skin(3)|stomach(2)	24		Esophageal squamous(42;0.131)				CTGATCAAATCAGAAAGGACA	0.388000													16	26					0	0	1	0	0
SLC44A2	57153	broad.mit.edu	37	19	10747058	10747058	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:10747058C>T	ENST00000586078.1	+	15	1402	c.1293C>T	c.(1291-1293)ttC>ttT	p.F431F	SLC44A2_ENST00000335757.5_Silent_p.F431F|SLC44A2_ENST00000407327.4_Silent_p.F429F	NM_020428.3	NP_065161.3	Q8IWA5	CTL2_HUMAN	solute carrier family 44 (choline transporter), member 2	431					positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane|plasma membrane	choline transmembrane transporter activity|signal transducer activity			NS(1)|breast(3)|endometrium(5)|kidney(1)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27			Epithelial(33;8.7e-06)|all cancers(31;2.77e-05)		Choline(DB00122)	AGTTCGCCTTCTACGGTGGTG	0.607000													45	48					0	0	1	0	0
HS6ST3	266722	broad.mit.edu	37	13	97484989	97484989	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:97484989G>A	ENST00000376705.2	+	2	977	c.953G>A	c.(952-954)aGc>aAc	p.S318N		NM_153456.3	NP_703157.2	Q8IZP7	H6ST3_HUMAN	heparan sulfate 6-O-sulfotransferase 3	318						integral to membrane	sulfotransferase activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|ovary(1)|pancreas(1)|skin(1)	20	all_neural(89;0.0878)|Medulloblastoma(90;0.163)					GCTGACCTCAGCCTGGTGGGC	0.512000													45	40					0	0	1	0	0
ARFGAP1	55738	broad.mit.edu	37	20	61917767	61917767	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:61917767C>T	ENST00000370275.4	+	13	1215	c.1123C>T	c.(1123-1125)Cgg>Tgg	p.R375W	ARFGAP1_ENST00000370283.4_Missense_Mutation_p.S295L|ARFGAP1_ENST00000353546.3_Missense_Mutation_p.S303L|ARFGAP1_ENST00000519604.1_Missense_Mutation_p.S250L|ARFGAP1_ENST00000519273.2_Missense_Mutation_p.S182L|ARFGAP1_ENST00000518794.2_3'UTR|ARFGAP1_ENST00000547204.1_Missense_Mutation_p.S229L			Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating protein 1	0					COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)	13	all_cancers(38;1.59e-09)					ACCTTTTTTTCGGGGAAAGCA	0.627000													9	53					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55913000	55913000	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:55913000G>A	ENST00000373965.2	-	15	2059	c.1665C>T	c.(1663-1665)atC>atT	p.I555I	PCDH15_ENST00000437009.1_Silent_p.I548I|PCDH15_ENST00000395432.2_Silent_p.I511I|PCDH15_ENST00000395430.1_Silent_p.I548I|PCDH15_ENST00000320301.6_Silent_p.I548I|PCDH15_ENST00000361849.3_Silent_p.I548I|PCDH15_ENST00000414778.1_Silent_p.I553I|PCDH15_ENST00000395446.1_Silent_p.I548I|PCDH15_ENST00000395438.1_Silent_p.I548I|PCDH15_ENST00000395445.1_Silent_p.I555I|PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000373957.3_Silent_p.I526I|PCDH15_ENST00000373955.1_Silent_p.I548I|PCDH15_ENST00000409834.1_Silent_p.I159I|PCDH15_ENST00000395433.1_Silent_p.I526I|PCDH15_ENST00000395442.1_Intron	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	548	Cadherin 5.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CCCCAACAAGGATTTCATATG	0.473000										HNSCC(58;0.16)			33	14					0	0	1	0	0
MTF1	4520	broad.mit.edu	37	1	38281084	38281084	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:38281084G>A	ENST00000373036.4	-	11	2126	c.1986C>T	c.(1984-1986)agC>agT	p.S662S		NM_005955.2	NP_005946.2	Q14872	MTF1_HUMAN	metal-regulatory transcription factor 1	662						nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|zinc ion binding			endometrium(3)|kidney(5)|large_intestine(6)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(1)	31	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)				GAGCCTGGGGGCTCGGCTCTG	0.637000													18	50					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180049771	180049771	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:180049771C>T	ENST00000261937.6	-	12	1695	c.1617G>A	c.(1615-1617)aaG>aaA	p.K539K	FLT4_ENST00000393347.3_Silent_p.K539K|FLT4_ENST00000424276.2_5'UTR|FLT4_ENST00000502649.1_Silent_p.K539K	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4	539	Ig-like C2-type 5.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CCTGGCCCACCTTGTTGGAGA	0.577000													14	29					0	0	1	0	0
CSMD1	64478	broad.mit.edu	37	8	3855603	3855603	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:3855603C>T	ENST00000602557.1	-	5	1195	c.640G>A	c.(640-642)Ggg>Agg	p.G214R	CSMD1_ENST00000602723.1_Missense_Mutation_p.G214R|CSMD1_ENST00000520002.1_Missense_Mutation_p.G214R|CSMD1_ENST00000542608.1_Missense_Mutation_p.G214R|CSMD1_ENST00000400186.3_Missense_Mutation_p.G214R|CSMD1_ENST00000539096.1_Missense_Mutation_p.G214R|CSMD1_ENST00000537824.1_Missense_Mutation_p.G214R			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	214	CUB 2.					integral to membrane		p.G214R(1)		breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CTGCTGGTCCCGCGTAAGGTT	0.572000													3	7					0	0	1	0	0
CACNA1E	777	broad.mit.edu	37	1	181706661	181706661	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:181706661G>A	ENST00000526775.1	+	22	3531	c.3365_splice	c.e22-1	p.P1122_splice	CACNA1E_ENST00000357570.5_Splice_Site_p.P1092_splice|CACNA1E_ENST00000367573.2_Splice_Site_p.P1141_splice|CACNA1E_ENST00000360108.3_Splice_Site_p.P1122_splice|CACNA1E_ENST00000367567.4_Splice_Site_p.P748_splice|CACNA1E_ENST00000358338.5_Splice_Site_p.P1073_splice|CACNA1E_ENST00000367570.1_Splice_Site_p.P1141_splice	NM_001205294.1	NP_001192223.1	Q15878	CAC1E_HUMAN	calcium channel, voltage-dependent, R type, alpha 1E subunit	1141					energy reserve metabolic process|membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	voltage-gated calcium channel activity			NS(2)|breast(9)|central_nervous_system(3)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(6)|kidney(4)|large_intestine(34)|lung(99)|ovary(6)|pancreas(1)|prostate(9)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	204						CTGCCCGCAGGATCCGGAGGG	0.622000													5	76					0	0	1	0	0
DNAH3	55567	broad.mit.edu	37	16	20966216	20966216	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:20966216C>T	ENST00000261383.3	-	55	10989	c.10990G>A	c.(10990-10992)Gcg>Acg	p.A3664T	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3664	AAA 6 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		CACATCACCGCCTTTGCACAG	0.522000													51	66					0	0	1	0	0
PRB4	5545	broad.mit.edu	37	12	11461252	11461252	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:11461252C>T	ENST00000279575.1	-	3	698	c.665G>A	c.(664-666)gGa>gAa	p.G222E	PRB4_ENST00000535904.1_Missense_Mutation_p.G222E|PRB4_ENST00000445719.2_Missense_Mutation_p.G153E	NM_001261399.1|NM_002723.4	NP_001248328.1|NP_002714.2	P10163	PRB4_HUMAN	proline-rich protein BstNI subfamily 4	285	9.5 X 21 AA tandem repeats of K-P-[EQ]- [GR]-[PR]-[PR]-P-Q-G-G-N-Q-[PS]-[QH]- [RG]-[PT]-P-P-[PH]-P-G.					extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|skin(4)|upper_aerodigestive_tract(3)	30						CTGGGGCTTTCCAGCAGGAGG	0.627000										HNSCC(22;0.051)			105	100					0	0	1	0	0
HIC2	23119	broad.mit.edu	37	22	21800043	21800043	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:21800043C>T	ENST00000443632.2	+	2	1231	c.859C>T	c.(859-861)Cct>Tct	p.P287S	HIC2_ENST00000407464.2_Missense_Mutation_p.P287S|HIC2_ENST00000407598.2_Missense_Mutation_p.P287S			Q96JB3	HIC2_HUMAN	hypermethylated in cancer 2	287					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	focal adhesion|nucleus	DNA binding|protein C-terminus binding|zinc ion binding			NS(1)|endometrium(4)|large_intestine(1)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16	Melanoma(16;0.000465)|Ovarian(15;0.00438)|Colorectal(54;0.0968)	Lung SC(17;0.0262)|all_lung(157;0.205)				GGCCTCTGCTCCTCCCGTTGC	0.672000													43	65					0	0	1	0	0
HTR2A	3356	broad.mit.edu	37	13	47469826	47469826	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:47469826C>T	ENST00000378688.4	-	1	347	c.216G>A	c.(214-216)caG>caA	p.Q72Q	HTR2A_ENST00000542664.1_Silent_p.Q72Q|HTR2A_ENST00000543956.1_Intron			P28223	5HT2A_HUMAN	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	72					ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(10)|ovary(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	AGTTTTTTTCCTGGAGATGAA	0.453000													43	46					0	0	1	0	0
FER1L6	654463	broad.mit.edu	37	8	125088481	125088481	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:125088481C>T	ENST00000522917.1	+	32	4341	c.4135C>T	c.(4135-4137)Ccc>Tcc	p.P1379S	FER1L6-AS2_ENST00000520031.1_RNA|FER1L6_ENST00000399018.1_Missense_Mutation_p.P1379S	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1379	C2 5.					integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CAAATCAGATCCCTACATTGT	0.413000													67	104					0	0	1	0	0
RSPO4	343637	broad.mit.edu	37	20	944609	944609	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:944609C>T	ENST00000217260.4	-	4	660	c.564G>A	c.(562-564)agG>agA	p.R188R	RSPO4_ENST00000400634.2_Intron	NM_001029871.3	NP_001025042.2	Q2I0M5	RSPO4_HUMAN	R-spondin 4	188	TSP type-1.				Wnt receptor signaling pathway	extracellular region	heparin binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7						TGGGACATTTCCTTGACTCAG	0.667000													38	30					0	0	1	0	0
RPL3L	6123	broad.mit.edu	37	16	1997207	1997207	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:1997207G>A	ENST00000268661.7	-	5	770	c.676C>T	c.(676-678)Cga>Tga	p.R226*		NM_005061.2	NP_005052.1	Q92901	RL3L_HUMAN	ribosomal protein L3-like	226					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome			NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	17						TTGACGCCTCGACCCTTGGTG	0.647000													49	66					0	0	1	0	0
SPERT	220082	broad.mit.edu	37	13	46287652	46287652	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:46287652G>A	ENST00000378966.3	+	2	800	c.384G>A	c.(382-384)aaG>aaA	p.K128K	SPERT_ENST00000310521.1_Silent_p.K164K			Q8NA61	SPERT_HUMAN	spermatid associated	164						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		GGCTGGCCAAGGAGTGCATGC	0.597000													56	57					0	0	1	0	0
FYB	2533	broad.mit.edu	37	5	39202604	39202604	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:39202604C>T	ENST00000351578.6	-	2	649	c.459G>A	c.(457-459)ccG>ccA	p.P153P	FYB_ENST00000512982.1_Silent_p.P153P|FYB_ENST00000515010.1_Silent_p.P153P|FYB_ENST00000540520.1_Silent_p.P163P|FYB_ENST00000505428.1_Silent_p.P153P	NM_199335.3	NP_955367.1	O15117	FYB_HUMAN	FYN binding protein	153					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			endometrium(2)|kidney(4)|large_intestine(6)|liver(1)|lung(29)|ovary(2)|upper_aerodigestive_tract(1)	45	all_lung(31;0.000343)		Epithelial(62;0.235)			GCCCAGATTTCGGGCCTAGTG	0.458000													105	57					0	0	1	0	0
HOXB3	3213	broad.mit.edu	37	17	46627775	46627775	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:46627775G>A	ENST00000470495.1	-	2	2664	c.1217C>T	c.(1216-1218)aCc>aTc	p.T406I	HOXB3_ENST00000472863.1_Missense_Mutation_p.T333I|HOXB-AS1_ENST00000508688.1_RNA|HOXB3_ENST00000489475.1_Missense_Mutation_p.T333I|HOXB3_ENST00000485909.2_Missense_Mutation_p.T274I|HOXB3_ENST00000311626.4_Missense_Mutation_p.T406I|HOXB-AS1_ENST00000502764.2_RNA|HOXB-AS1_ENST00000435312.1_RNA|HOXB3_ENST00000490677.1_Missense_Mutation_p.T272I|HOXB3_ENST00000498678.1_Missense_Mutation_p.T406I|HOXB3_ENST00000476342.1_Missense_Mutation_p.T406I|HOXB-AS3_ENST00000465846.2_RNA|HOXB3_ENST00000460160.1_Missense_Mutation_p.T274I			P14651	HXB3_HUMAN	homeobox B3	406					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|lung(16)|prostate(4)|upper_aerodigestive_tract(1)	30						GTCTGTGTAGGTGGGGTGGGG	0.612000											OREG0024516	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	53	71					0	0	1	0	0
FUT9	10690	broad.mit.edu	37	6	96651991	96651991	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:96651991G>A	ENST00000302103.5	+	3	1286	c.960G>A	c.(958-960)aaG>aaA	p.K320K		NM_006581.3	NP_006572.2	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	320					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	34		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		ACTGGAGGAAGGATTTCACTG	0.368000													22	51					0	0	1	0	0
PKN1	5585	broad.mit.edu	37	19	14557315	14557315	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:14557315C>T	ENST00000242783.6	+	4	717	c.552C>T	c.(550-552)ctC>ctT	p.L184L	PKN1_ENST00000342216.4_Silent_p.L190L	NM_002741.3	NP_002732.3	Q16512	PKN1_HUMAN	protein kinase N1	184					activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			breast(3)|central_nervous_system(1)|cervix(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)	31						GCATGCAACTCCGCCGGGCGC	0.612000													23	98					0	0	1	0	0
ESYT1	23344	broad.mit.edu	37	12	56522221	56522221	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:56522221G>A	ENST00000394048.5	+	1	382	c.118G>A	c.(118-120)Ggc>Agc	p.G40S	RP11-603J24.5_ENST00000550947.1_RNA|ESYT1_ENST00000267113.4_Missense_Mutation_p.G40S|RP11-603J24.5_ENST00000549438.1_RNA|ESYT1_ENST00000541590.1_Missense_Mutation_p.G40S	NM_001184796.1|NM_015292.2	NP_001171725.1|NP_056107.1	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	40						integral to membrane				breast(2)|endometrium(2)|large_intestine(4)|lung(10)|ovary(5)|prostate(1)|skin(3)|urinary_tract(1)	28						AGGTTCTGGGGGCCAACCTGC	0.697000													6	11					0	0	1	0	0
CCT8	10694	broad.mit.edu	37	21	30437396	30437396	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:30437396G>C	ENST00000286788.4	-	7	861	c.655C>G	c.(655-657)Cat>Gat	p.H219D	CCT8_ENST00000470450.1_5'UTR|CCT8_ENST00000542732.1_Missense_Mutation_p.H200D|CCT8_ENST00000540844.1_Missense_Mutation_p.H146D	NM_006585.2	NP_006576.2	P50990	TCPQ_HUMAN	chaperonin containing TCP1, subunit 8 (theta)	219					'de novo' posttranslational protein folding	aggresome|cytosol|intermediate filament cytoskeleton|microtubule organizing center	ATP binding|ATPase activity, coupled|unfolded protein binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(4)|liver(1)|lung(1)|prostate(3)	14						ACCATGCCATGCAATACTGAA	0.388000													25	47					0	0	1	0	0
KLHL20	27252	broad.mit.edu	37	1	173702945	173702945	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:173702945A>T	ENST00000209884.4	+	3	253	c.117A>T	c.(115-117)caA>caT	p.Q39H	KLHL20_ENST00000546011.1_Intron|KLHL20_ENST00000493170.1_3'UTR	NM_014458.3	NP_055273.2	Q9Y2M5	KLH20_HUMAN	kelch-like family member 20	39					cytoskeleton organization|negative regulation of apoptosis|proteasomal ubiquitin-dependent protein catabolic process|response to interferon-alpha	actin cytoskeleton|cell surface|Cul3-RING ubiquitin ligase complex|Golgi apparatus|perinuclear region of cytoplasm|PML body	actin binding|interferon-gamma binding|ubiquitin-protein ligase activity			breast(3)|endometrium(6)|kidney(1)|large_intestine(8)|lung(14)|ovary(1)|upper_aerodigestive_tract(1)	34						GGGTTCCCCAACCTGCCCGCA	0.527000													86	29					0	0	1	0	0
CNTN5	53942	broad.mit.edu	37	11	100221556	100221556	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:100221556G>A	ENST00000524871.1	+	24	3444	c.3154G>A	c.(3154-3156)Gga>Aga	p.G1052R	CNTN5_ENST00000418526.2_Missense_Mutation_p.G978R|CNTN5_ENST00000528682.1_Missense_Mutation_p.G1052R|CNTN5_ENST00000279463.3_Missense_Mutation_p.G1052R|CNTN5_ENST00000524560.1_3'UTR	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	1052	Fibronectin type-III 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TAGTGAAGGAGGAGATGGAAC	0.393000													25	41					0	0	1	0	0
PKP2	5318	broad.mit.edu	37	12	33030890	33030890	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:33030890G>A	ENST00000340811.4	-	3	1032	c.924C>T	c.(922-924)gtC>gtT	p.V308V	PKP2_ENST00000070846.6_Silent_p.V308V	NM_001005242.2	NP_001005242.2	Q99959	PKP2_HUMAN	plakophilin 2	308					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			NS(1)|breast(2)|endometrium(1)|kidney(9)|large_intestine(8)|lung(21)|ovary(1)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	50	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					AATCCACGGCGACACTGGGCC	0.637000													33	28					0	0	1	0	0
ATP9A	10079	broad.mit.edu	37	20	50226648	50226648	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:50226648G>A	ENST00000338821.5	-	24	2892	c.2628C>T	c.(2626-2628)ctC>ctT	p.L876L	ATP9A_ENST00000402822.1_Silent_p.L755L|ATP9A_ENST00000311637.5_Silent_p.L740L	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	876					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						ACCCAATGATGAGGAATCCTT	0.433000													14	32					0	0	1	0	0
ERC2	26059	broad.mit.edu	37	3	56468457	56468457	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:56468457C>T	ENST00000288221.6	-	2	834	c.579G>A	c.(577-579)gaG>gaA	p.E193E		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	193						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		TCAAGACTCTCTCCTTCTTAA	0.468000													47	57					0	0	1	0	0
CYYR1	116159	broad.mit.edu	37	21	27945290	27945290	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:27945290G>A	ENST00000435845.2	-	1	313	c.294C>T	c.(292-294)ccC>ccT	p.P98P	CYYR1_ENST00000400043.3_5'UTR|CYYR1_ENST00000299340.4_5'UTR			Q96J86	CYYR1_HUMAN	cysteine/tyrosine-rich 1	139						integral to membrane				large_intestine(2)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(2)	15						TTGGAGCGAAGGGAGAGCCCG	0.647000													22	29					0	0	1	0	0
GABRP	2568	broad.mit.edu	37	5	170222292	170222292	+	Silent	SNP	G	G	A	rs41315922		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:170222292G>A	ENST00000518525.1	+	6	785	c.321G>A	c.(319-321)ctG>ctA	p.L107L	GABRP_ENST00000519385.1_Silent_p.L107L|GABRP_ENST00000519598.1_Silent_p.L107L|GABRP_ENST00000265294.4_Silent_p.L107L			O00591	GBRP_HUMAN	gamma-aminobutyric acid (GABA) A receptor, pi	107						cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(5)|large_intestine(4)|lung(11)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	29	Renal(175;0.000159)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0109)|all_neural(177;0.0298)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GCTTCACTCTGGATGCCCGCC	0.567000													18	159					0	0	1	0	0
MT1JP	4498	broad.mit.edu	37	16	56670343	56670343	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:56670343C>T	ENST00000564564.1	+	0	669																											TTTTCCTCTTCCTTGCAGGTG	0.582000													18	42					0	0	1	0	0
ALOX5	240	broad.mit.edu	37	10	45924212	45924212	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:45924212G>A	ENST00000374391.2	+	7	1034	c.981_splice	c.e7+1	p.Q327_splice	ALOX5_ENST00000542434.1_Splice_Site_p.Q327_splice	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	327	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	TTGCCATCCAGGTAGGCTGCT	0.567000													20	9					0	0	1	0	0
ABCC2	1244	broad.mit.edu	37	10	101590492	101590492	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:101590492C>T	ENST00000370449.4	+	21	2880	c.2767C>T	c.(2767-2769)Cat>Tat	p.H923Y		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	923						apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	CAATGGCAGGCATCTGAAGTC	0.463000													25	21					0	0	1	0	0
NEGR1	257194	broad.mit.edu	37	1	72400827	72400827	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:72400827G>A	ENST00000357731.4	-	2	583	c.344C>T	c.(343-345)cCa>cTa	p.P115L	NEGR1_ENST00000306821.3_5'UTR|NEGR1_ENST00000467479.1_5'UTR|NEGR1_ENST00000434200.1_Missense_Mutation_p.P113L	NM_173808.2	NP_776169.2	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1	115	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane				endometrium(1)|kidney(4)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		ACACGTGTATGGGCCATCATC	0.418000													33	20					0	0	1	0	0
BLMH	642	broad.mit.edu	37	17	28598321	28598321	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:28598321G>A	ENST00000261714.6	-	10	1288	c.1114C>T	c.(1114-1116)Cac>Tac	p.H372Y	BLMH_ENST00000394819.3_Missense_Mutation_p.H285Y	NM_000386.3	NP_000377.1	Q13867	BLMH_HUMAN	bleomycin hydrolase	372					proteolysis	cytoplasm|nucleus	aminopeptidase activity|carboxypeptidase activity|cysteine-type endopeptidase activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|ovary(1)|prostate(1)|stomach(1)	13						GTCATGGCGTGGGTCATAAGT	0.453000													15	38					0	0	1	0	0
DSG2	1829	broad.mit.edu	37	18	29122620	29122620	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:29122620G>A	ENST00000261590.8	+	14	2348	c.2139G>A	c.(2137-2139)gaG>gaA	p.E713E	RP11-75N4.2_ENST00000583706.1_RNA	NM_001943.3	NP_001934.2	Q14126	DSG2_HUMAN	desmoglein 2	713			E -> K.		cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			breast(2)|central_nervous_system(6)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(17)|ovary(2)|prostate(4)|skin(2)|urinary_tract(1)	49			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			AGATGTCCGAGATGGATGGAA	0.502000													43	71					0	0	1	0	0
ROBO4	54538	broad.mit.edu	37	11	124766094	124766094	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:124766094C>T	ENST00000306534.3	-	4	1164	c.679_splice	c.e4+1	p.E227_splice	ROBO4_ENST00000533054.1_Splice_Site_p.E82_splice|ROBO4_ENST00000526899.1_5'UTR	NM_019055.5	NP_061928.4	Q8WZ75	ROBO4_HUMAN	roundabout, axon guidance receptor, homolog 4 (Drosophila)	227					angiogenesis|cell differentiation	integral to membrane	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(42)|ovary(1)|prostate(4)|skin(5)|urinary_tract(3)	76	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		CTGCCCTTACCCTGGATGGAA	0.597000													25	61					0	0	1	0	0
HERC2P3	283755	broad.mit.edu	37	15	20643923	20643923	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:20643923G>A	ENST00000428453.1	-	0	3536																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						CCTTCAGGGTGATGCGAGTCA	0.542000													15	60					0	0	1	0	0
HSD3B7	80270	broad.mit.edu	37	16	30997780	30997780	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:30997780G>A	ENST00000262520.6	+	4	649	c.359G>A	c.(358-360)gGa>gAa	p.G120E	HSD3B7_ENST00000297679.5_Missense_Mutation_p.G120E|HSD3B7_ENST00000353250.5_Missense_Mutation_p.G120E	NM_001142777.1	NP_001136249.1	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7	120					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12						GTGCAGACCGGAACACGGTTC	0.577000													28	43					0	0	1	0	0
POM121L12	285877	broad.mit.edu	37	7	53103836	53103836	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:53103836G>A	ENST00000408890.4	+	1	488	c.472G>A	c.(472-474)Gcc>Acc	p.A158T		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	158										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						TGGACAGAGAgcccgccccgc	0.726000													22	20					0	0	1	0	0
SYNRG	11276	broad.mit.edu	37	17	35902229	35902229	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:35902229G>A	ENST00000339208.6	-	15	3187	c.3047C>T	c.(3046-3048)aCc>aTc	p.T1016I	SYNRG_ENST00000591288.1_Missense_Mutation_p.T810I|SYNRG_ENST00000345615.4_Missense_Mutation_p.T938I|SYNRG_ENST00000502449.2_Missense_Mutation_p.T893I|SYNRG_ENST00000585472.1_Missense_Mutation_p.T937I|SYNRG_ENST00000394378.2_Missense_Mutation_p.T938I|SYNRG_ENST00000346661.4_Missense_Mutation_p.T1016I	NM_001163544.1|NM_001163545.1|NM_007247.4	NP_001157016.1|NP_001157017.1|NP_009178.3	Q9UMZ2	SYNRG_HUMAN	synergin, gamma	1016					endocytosis|intracellular protein transport	AP-1 adaptor complex	calcium ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(14)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TTCGTTCGGGGTTTCTTGAGA	0.473000													34	59					0	0	1	0	0
ZNF804A	91752	broad.mit.edu	37	2	185802568	185802568	+	Silent	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:185802568A>G	ENST00000302277.6	+	4	3039	c.2445A>G	c.(2443-2445)aaA>aaG	p.K815K		NM_194250.1	NP_919226.1	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	815						intracellular	zinc ion binding			NS(5)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(22)|liver(2)|lung(79)|ovary(7)|pancreas(1)|prostate(2)|skin(12)|urinary_tract(1)	146						GGAGGCGAAAAAGAGGCAGAT	0.388000													32	28					0	0	1	0	0
NCKAP5	344148	broad.mit.edu	37	2	133486462	133486462	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:133486462C>T	ENST00000409261.1	-	18	5880	c.5507G>A	c.(5506-5508)gGa>gAa	p.G1836E	NCKAP5_ENST00000317721.6_Missense_Mutation_p.G1836E|NCKAP5_ENST00000405974.3_Missense_Mutation_p.G517E|NCKAP5_ENST00000409213.1_Missense_Mutation_p.G517E	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	1836							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						TTCAGCATATCCGAATGATGA	0.542000													94	155					0	0	1	0	0
C6orf25	80739	broad.mit.edu	37	6	31692761	31692761	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:31692761G>A	ENST00000375809.3	+	6	666	c.655G>A	c.(655-657)Gga>Aga	p.G219R	C6orf25_ENST00000375805.2_Silent_p.A188A|C6orf25_ENST00000375810.4_3'UTR	NM_025260.3|NM_138272.2|NM_138277.2	NP_079536.2|NP_612116.1|NP_612121.1	O95866	G6B_HUMAN	chromosome 6 open reading frame 25	0						endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	heparin binding|receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	9						TGCTCTATGCGGATCTGGACC	0.557000													13	64					0	0	1	0	0
TNFAIP8L3	388121	broad.mit.edu	37	15	51350462	51350462	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:51350462G>A	ENST00000327536.5	-	3	594	c.495C>T	c.(493-495)atC>atT	p.I165I	RP11-108K3.1_ENST00000559909.1_lincRNA	NM_207381.2	NP_997264.2	Q5GJ75	TP8L3_HUMAN	tumor necrosis factor, alpha-induced protein 8-like 3	165										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	11				all cancers(107;0.000389)|GBM - Glioblastoma multiforme(94;0.00338)		AGTCTTTCATGATCTTGTGGG	0.463000													30	102					0	0	1	0	0
OVCH2	341277	broad.mit.edu	37	11	7725292	7725292	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:7725292G>A	ENST00000454689.1	-	0	242				OVCH2_ENST00000534193.1_RNA	NM_198185.3	NP_937828.3			ovochymase 2 (gene/pseudogene)											cervix(1)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(2)	15				Epithelial(150;7.9e-08)|BRCA - Breast invasive adenocarcinoma(625;0.197)		GTGGTGAGACGATGCTTCCTC	0.473000													8	5					0	0	1	0	0
TRBV7-4	28594	broad.mit.edu	37	7	142176575	142176575	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:142176575C>T	ENST00000390369.2	-	0	100																											ATCCCGTCCCCTCTTTGCGAC	0.478000													21	38					0	0	1	0	0
NPR2	4882	broad.mit.edu	37	9	35800784	35800784	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:35800784C>T	ENST00000342694.2	+	6	1552	c.1297C>T	c.(1297-1299)Ccc>Tcc	p.P433S		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	433					intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	GGGGGCTCCTCCCTCGGACAA	0.577000													24	10					0	0	1	0	0
RAD51AP2	729475	broad.mit.edu	37	2	17699064	17699064	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:17699064C>T	ENST00000399080.2	-	1	642	c.619G>A	c.(619-621)Gaa>Aaa	p.E207K		NM_001099218.2	NP_001092688.1	Q09MP3	R51A2_HUMAN	RAD51 associated protein 2	207										endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(10)|liver(1)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TTCTTAATTTCATGAAATGGT	0.299000													4	24					0	0	1	0	0
SIGLECL1	284369	broad.mit.edu	37	19	51771825	51771825	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:51771825G>A	ENST00000316401.7	+	6	949	c.567_splice	c.e6-1	p.E190_splice	SIGLECL1_ENST00000597824.1_Splice_Site_p.E96_splice|SIGLECL1_ENST00000593968.1_3'UTR|CTD-3187F8.2_ENST00000597569.1_RNA	NM_173635.1	NP_775906.1			SIGLEC family like 1																		TCGCTTTCAGGAAAAGCAAGA	0.428000													17	11					0	0	1	0	0
LRRC3B	116135	broad.mit.edu	37	3	26751332	26751332	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:26751332G>A	ENST00000396641.2	+	2	761	c.169G>A	c.(169-171)Gaa>Aaa	p.E57K	LRRC3B_ENST00000417744.1_Missense_Mutation_p.E57K|LRRC3B_ENST00000456208.2_Missense_Mutation_p.E57K	NM_052953.2	NP_443185.1	Q96PB8	LRC3B_HUMAN	leucine rich repeat containing 3B	57	LRRNT.					integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|pancreas(2)|prostate(1)|skin(4)	21						AAATCTCAAGGAAATACCTAG	0.413000													15	37					0	0	1	0	0
IL1F10	84639	broad.mit.edu	37	2	113832286	113832286	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:113832286C>T	ENST00000337569.3	+	3	180	c.105C>T	c.(103-105)ctC>ctT	p.L35L	IL1F10_ENST00000393197.2_Intron|IL1F10_ENST00000341010.2_Intron			Q8WWZ1	IL1FA_HUMAN	interleukin 1 family, member 10 (theta)	35						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity			endometrium(1)|lung(6)|ovary(1)	8						ACTCTTCTCTCTCTTCCCTCC	0.592000													35	157					0	0	1	0	0
MUSK	4593	broad.mit.edu	37	9	113449398	113449398	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:113449398C>T	ENST00000416899.2	+	3	334	c.206_splice	c.e3-1	p.L70_splice	MUSK_ENST00000189978.5_Splice_Site_p.L70_splice|MUSK_ENST00000374440.3_5'UTR|MUSK_ENST00000374448.4_Splice_Site_p.L70_splice			O15146	MUSK_HUMAN	muscle, skeletal, receptor tyrosine kinase	70	Ig-like 1.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(3)|large_intestine(7)|lung(23)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	49						GACCTGCAGACTCTTTGACAC	0.453000													27	27					0	0	1	0	0
NSUN6	221078	broad.mit.edu	37	10	18874971	18874971	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:18874971G>A	ENST00000377304.4	-	8	1247	c.829C>T	c.(829-831)Cag>Tag	p.Q277*		NM_182543.2	NP_872349.1	Q8TEA1	NSUN6_HUMAN	NOP2/Sun domain family, member 6	277							methyltransferase activity|RNA binding			endometrium(1)|large_intestine(2)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	15						AAGGCATTCTGTTTGATTTTT	0.348000													31	11					0	0	1	0	0
DOCK2	1794	broad.mit.edu	37	5	169494645	169494645	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:169494645G>A	ENST00000256935.8	+	45	4679	c.4599G>A	c.(4597-4599)ggG>ggA	p.G1533G	DOCK2_ENST00000520908.1_Silent_p.G1025G|DOCK2_ENST00000540750.1_Silent_p.G594G|DOCK2_ENST00000523351.1_3'UTR	NM_004946.2	NP_004937.1	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	1533	DHR-2.				actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCCTGAACGGGATTGTGGACC	0.532000													35	43					0	0	1	0	0
ZP4	57829	broad.mit.edu	37	1	238045787	238045787	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:238045787C>T	ENST00000366570.4	-	12	1716	c.1558G>A	c.(1558-1560)Gcc>Acc	p.A520T	RP11-193H5.1_ENST00000450451.1_RNA	NM_021186.3	NP_067009.1	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4	520					acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			breast(6)|cervix(2)|endometrium(5)|kidney(2)|large_intestine(8)|lung(42)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	73	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			ACTAACAAGGCTCCAAGGATT	0.468000													89	46					0	0	1	0	0
LRRC32	2615	broad.mit.edu	37	11	76370873	76370873	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:76370873G>A	ENST00000407242.2	-	3	2006	c.1764C>T	c.(1762-1764)ggC>ggT	p.G588G	LRRC32_ENST00000404995.1_Silent_p.G588G|AP001189.4_ENST00000447519.1_RNA|LRRC32_ENST00000464145.1_Intron|LRRC32_ENST00000260061.5_Silent_p.G588G	NM_005512.2	NP_005503.1	Q14392	LRC32_HUMAN	leucine rich repeat containing 32	588	LRRCT.					integral to plasma membrane				endometrium(1)|large_intestine(3)|lung(26)|upper_aerodigestive_tract(1)	31						CGTCCACACGGCCCTGGTGCA	0.677000													15	62					0	0	1	0	0
TNS1	7145	broad.mit.edu	37	2	218682615	218682615	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:218682615G>A	ENST00000171887.4	-	24	4580	c.4128C>T	c.(4126-4128)gcC>gcT	p.A1376A	TNS1_ENST00000430930.1_Silent_p.A1355A|TNS1_ENST00000419504.1_Silent_p.A1363A	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	1376						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		CTTGCCGGAAGGCTGCGGAGT	0.647000													9	26					0	0	1	0	0
SPAG17	200162	broad.mit.edu	37	1	118526499	118526499	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:118526499G>A	ENST00000336338.5	-	42	5872	c.5807C>T	c.(5806-5808)tCt>tTt	p.S1936F	SPAG17_ENST00000492438.1_5'UTR	NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1936						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CTTTGTAAAAGAAGGCAGTTT	0.308000													18	11					0	0	1	0	0
KRT18	3875	broad.mit.edu	37	12	53345398	53345398	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:53345398G>A	ENST00000550600.1	+	5	845	c.791G>A	c.(790-792)cGa>cAa	p.R264Q	KRT18_ENST00000388835.3_Missense_Mutation_p.R264Q|KRT18_ENST00000388837.2_Missense_Mutation_p.R264Q			P05783	K1C18_HUMAN	keratin 18	264	Coil 2.|Interaction with DNAJB6.|Necessary for interaction with PNN.|Rod.				anatomical structure morphogenesis|cell cycle|Golgi to plasma membrane CFTR protein transport|interspecies interaction between organisms|negative regulation of apoptosis	centriolar satellite|keratin filament|perinuclear region of cytoplasm	protein binding|structural molecule activity			central_nervous_system(1)|large_intestine(2)|lung(4)|prostate(3)|skin(1)	11						CGGAAGAACCGAGAGGAGCTA	0.602000													20	15					0	0	1	0	0
HCLS1	3059	broad.mit.edu	37	3	121351032	121351032	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:121351032C>T	ENST00000314583.3	-	13	1332		c.e13-1		HCLS1_ENST00000428394.2_Splice_Site|HCLS1_ENST00000473883.1_Splice_Site	NM_005335.4	NP_005326.2	P14317	HCLS1_HUMAN	hematopoietic cell-specific Lyn substrate 1						erythrocyte differentiation|intracellular signal transduction|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of STAT protein|response to hormone stimulus	mitochondrion|nucleus|plasma membrane	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35				GBM - Glioblastoma multiforme(114;0.0912)		CCTGATGATCCTGCATAATGA	0.512000													18	35					0	0	1	0	0
LRRC4C	57689	broad.mit.edu	37	11	40137125	40137125	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:40137125G>A	ENST00000278198.2	-	2	2681	c.718C>T	c.(718-720)Cag>Tag	p.Q240*	LRRC4C_ENST00000530763.1_Nonsense_Mutation_p.Q240*|LRRC4C_ENST00000528697.1_Nonsense_Mutation_p.Q240*|LRRC4C_ENST00000527150.1_Nonsense_Mutation_p.Q240*			Q9HCJ2	LRC4C_HUMAN	leucine rich repeat containing 4C	240					regulation of axonogenesis	integral to membrane	protein binding			NS(2)|central_nervous_system(3)|endometrium(1)|large_intestine(14)|lung(43)|ovary(5)|prostate(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	86		all_lung(304;0.0575)|Lung NSC(402;0.138)				ATCAAACCCTGGAAAGAGCCA	0.458000													34	45					0	0	1	0	0
FUT9	10690	broad.mit.edu	37	6	96651213	96651213	+	Missense_Mutation	SNP	T	T	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:96651213T>G	ENST00000302103.5	+	3	508	c.182T>G	c.(181-183)tTt>tGt	p.F61C		NM_006581.3	NP_006572.2	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3) fucosyltransferase)	61					L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(6)|liver(2)|lung(10)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	34		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		ACTGATTATTTTAATGAAACT	0.418000													48	44					0	0	1	0	0
CRISP3	10321	broad.mit.edu	37	6	49701475	49701475	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:49701475C>T	ENST00000433368.2	-	5	502	c.433G>A	c.(433-435)Gat>Aat	p.D145N	CRISP3_ENST00000263045.4_Missense_Mutation_p.D135N|CRISP3_ENST00000423399.2_Missense_Mutation_p.D32N|CRISP3_ENST00000393666.1_Missense_Mutation_p.D122N|CRISP3_ENST00000371159.4_Missense_Mutation_p.D153N	NM_001190986.1	NP_001177915.1	P54108	CRIS3_HUMAN	cysteine-rich secretory protein 3	122					innate immune response	proteinaceous extracellular matrix|specific granule		p.D122Y(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(14)|skin(6)|upper_aerodigestive_tract(1)	27	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			AAGTCAAAATCATTGTACTCA	0.428000													14	39					0	0	1	0	0
CPM	1368	broad.mit.edu	37	12	69265695	69265695	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:69265695G>A	ENST00000551568.1	-	4	360	c.300C>T	c.(298-300)ctC>ctT	p.L100L	CPM_ENST00000338356.3_Silent_p.L100L|CPM_ENST00000546373.1_Silent_p.L100L	NM_001005502.2|NM_198320.3	NP_001005502.1|NP_938079.1	P14384	CBPM_HUMAN	carboxypeptidase M	100					anatomical structure morphogenesis|proteolysis	anchored to membrane|cytoplasm|nucleus|plasma membrane	metallocarboxypeptidase activity|zinc ion binding			large_intestine(1)|lung(6)|prostate(2)	9	all_epithelial(5;1.09e-35)|Lung NSC(4;1.47e-33)|all_lung(4;1.02e-31)|Breast(13;1.59e-06)		all cancers(2;2.69e-50)|GBM - Glioblastoma multiforme(2;7.34e-41)|BRCA - Breast invasive adenocarcinoma(5;5.38e-10)|Lung(24;4.61e-05)|LUAD - Lung adenocarcinoma(15;0.000376)|STAD - Stomach adenocarcinoma(21;0.00372)|Kidney(9;0.143)			CACTGGTTACGAGATAGTCAA	0.443000													27	20					0	0	1	0	0
DBNDD1	79007	broad.mit.edu	37	16	90076441	90076441	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:90076441C>T	ENST00000304733.3	-	1	88	c.15G>A	c.(13-15)tgG>tgA	p.W5*	DBNDD1_ENST00000002501.6_Intron|DBNDD1_ENST00000568838.1_Intron|DBNDD1_ENST00000392973.3_5'UTR	NM_024043.2	NP_076948.2	Q9H9R9	DBND1_HUMAN	dysbindin (dystrobrevin binding protein 1) domain containing 1	0						cytoplasm				kidney(1)|large_intestine(1)|lung(1)	3		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0275)		AAATATTCTTCCAGGTTTCTC	0.468000													21	42					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179560117	179560117	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179560117G>A	ENST00000589042.1	-	115	31452	c.31228C>T	c.(31228-31230)Cca>Tca	p.P10410S	TTN_ENST00000342992.6_Missense_Mutation_p.P9166S|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.P10093S|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10093	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTTTGGCTGGAACTTTTCTC	0.343000													29	38					0	0	1	0	0
MME	4311	broad.mit.edu	37	3	154864963	154864963	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:154864963C>T	ENST00000460393.1	+	15	1567	c.1447C>T	c.(1447-1449)Cct>Tct	p.P483S	MME_ENST00000462745.1_Missense_Mutation_p.P483S|MME_ENST00000360490.2_Missense_Mutation_p.P483S|MME_ENST00000493237.1_Missense_Mutation_p.P483S|MME_ENST00000492661.1_Missense_Mutation_p.P483S	NM_000902.3|NM_007287.2	NP_000893.2|NP_009218.2	P08473	NEP_HUMAN	membrane metallo-endopeptidase	483					cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding	p.P483A(1)		central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(31)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	64		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	GATCGGCTATCCTGATGACAT	0.328000													14	36					0	0	1	0	0
MAPT	4137	broad.mit.edu	37	17	44067305	44067305	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:44067305C>T	ENST00000344290.5	+	8	1566	c.1244C>T	c.(1243-1245)cCc>cTc	p.P415L	MAPT_ENST00000574436.1_Intron|MAPT_ENST00000535772.1_Intron|MAPT_ENST00000446361.3_Intron|MAPT_ENST00000431008.3_Intron|MAPT_ENST00000420682.2_Intron|MAPT_ENST00000415613.2_Missense_Mutation_p.P415L|MAPT_ENST00000340799.5_Intron|MAPT_ENST00000571987.1_Missense_Mutation_p.P415L|MAPT_ENST00000351559.5_Intron|MAPT_ENST00000347967.5_Intron|MAPT_ENST00000334239.8_Intron|MAPT_ENST00000576518.1_Intron|MAPT_ENST00000262410.5_Missense_Mutation_p.P415L|MAPT_ENST00000570299.1_Intron	NM_001123066.3	NP_001116538.2	P10636	TAU_HUMAN	microtubule-associated protein tau	415					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			breast(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		Melanoma(429;0.216)				CCCAAACACCCCACTCCTGGT	0.468000													117	208					0	0	1	0	0
SLA	6503	broad.mit.edu	37	8	134072500	134072500	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:134072500G>A	ENST00000427060.2	-	1	103	c.26C>T	c.(25-27)cCa>cTa	p.P9L	TG_ENST00000377869.1_Intron|SLA_ENST00000524345.1_Intron|TG_ENST00000542445.1_Intron|SLA_ENST00000395352.3_Intron|SLA_ENST00000518565.1_Intron|TG_ENST00000220616.4_Intron|SLA_ENST00000517648.1_Intron|SLA_ENST00000338087.5_Intron|TG_ENST00000519543.1_Intron	NM_006748.3	NP_006739.2	Q13239	SLAP1_HUMAN	Src-like-adaptor	0						endosome	SH3/SH2 adaptor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|liver(1)|lung(6)|prostate(1)|skin(1)	17	all_epithelial(106;3.51e-21)|Lung NSC(106;4.24e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0279)|Breast(495;0.037)	BRCA - Breast invasive adenocarcinoma(115;0.000701)			CCCTCCAAGTGGAGAATGACC	0.502000													13	9					0	0	1	0	0
CES1	1066	broad.mit.edu	37	16	55862781	55862781	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:55862781C>T	ENST00000422046.2	-	2	436	c.155G>A	c.(154-156)gGa>gAa	p.G52E	CES1_ENST00000360526.3_Missense_Mutation_p.G53E|CES1_ENST00000361503.4_Missense_Mutation_p.G52E			P23141	EST1_HUMAN	carboxylesterase 1	52					response to toxin	endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity								all cancers(182;0.13)|Epithelial(162;0.137)	Aminoglutethimide(DB00357)|Bezafibrate(DB01393)|Cholestyramine(DB01432)|Moexipril(DB00691)	AAAAGGGATTCCCAGGAAAAT	0.567000													8	72					0	0	1	0	0
PTAFR	5724	broad.mit.edu	37	1	28476822	28476822	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:28476822G>A	ENST00000373857.3	-	2	1345	c.711C>T	c.(709-711)gtC>gtT	p.V237V	PTAFR_ENST00000539896.1_Silent_p.V237V|PTAFR_ENST00000305392.3_Silent_p.V237V	NM_000952.4|NM_001164722.2|NM_001164723.2	NP_000943.1|NP_001158194.1|NP_001158195.1	P25105	PTAFR_HUMAN	platelet-activating factor receptor	237					chemotaxis|inflammatory response|interferon-gamma-mediated signaling pathway|phosphatidylinositol-mediated signaling	integral to plasma membrane|nucleus	phospholipid binding|platelet activating factor receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(8)|stomach(1)	15		Colorectal(325;0.000147)|Renal(390;0.00357)|Lung NSC(340;0.00715)|all_lung(284;0.00732)|Breast(348;0.0174)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0545)|all_neural(195;0.0557)		UCEC - Uterine corpus endometrioid carcinoma (279;0.215)|OV - Ovarian serous cystadenocarcinoma(117;6e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|STAD - Stomach adenocarcinoma(196;0.00678)|READ - Rectum adenocarcinoma(331;0.0649)		ACACCGCCAAGACCGTGCACA	0.617000													11	47					0	0	1	0	0
TAAR1	134864	broad.mit.edu	37	6	132966667	132966667	+	Missense_Mutation	SNP	A	A	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:132966667A>T	ENST00000275216.1	-	1	475	c.476T>A	c.(475-477)aTc>aAc	p.I159N		NM_138327.1	NP_612200.1	Q96RJ0	TAAR1_HUMAN	trace amine associated receptor 1	159						plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)	18	Breast(56;0.135)			OV - Ovarian serous cystadenocarcinoma(155;0.00616)|GBM - Glioblastoma multiforme(226;0.0154)	Amphetamine(DB00182)	CTCCAGAAAGATCATTCCAAA	0.388000													34	32					0	0	1	0	0
CD84	8832	broad.mit.edu	37	1	160535278	160535278	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:160535278C>T	ENST00000368054.3	-	2	339	c.304G>A	c.(304-306)Gaa>Aaa	p.E102K	RP11-528G1.2_ENST00000446952.1_RNA|CD84_ENST00000534968.1_Intron|CD84_ENST00000368047.3_5'UTR|CD84_ENST00000311224.4_Missense_Mutation_p.E102K|CD84_ENST00000368051.3_Missense_Mutation_p.E102K|CD84_ENST00000368048.3_Missense_Mutation_p.E102K	NM_003874.3	NP_003865.1	Q9UIB8	SLAF5_HUMAN	CD84 molecule	102					blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity	p.M101_E102>I*(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(1)	24	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			CCTGCGTCTTCCATCCTCAGA	0.458000													150	82					0	0	1	0	0
UGT2A3	79799	broad.mit.edu	37	4	69798452	69798452	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:69798452G>A	ENST00000251566.4	-	3	920	c.890C>T	c.(889-891)tCa>tTa	p.S297L	UGT2A3_ENST00000420231.2_Missense_Mutation_p.S8L	NM_024743.3	NP_079019.3	Q6UWM9	UD2A3_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide A3	297						integral to membrane	glucuronosyltransferase activity			NS(1)|breast(1)|central_nervous_system(1)|kidney(5)|large_intestine(7)|lung(16)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						ATCTTCCCCTGAACTCTGGAC	0.353000													21	108					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64673916	64673916	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:64673916C>T	ENST00000421419.2	-	21	3187	c.3073G>A	c.(3073-3075)Gag>Aag	p.E1025K	ATG2A_ENST00000377264.3_Missense_Mutation_p.E1025K			Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1025							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						ACCCCTTCCTCCGATGGGTAG	0.692000													23	41					0	0	1	0	0
ADAM7	8756	broad.mit.edu	37	8	24324458	24324458	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:24324458C>T	ENST00000175238.6	+	6	619	c.536C>T	c.(535-537)aCt>aTt	p.T179I	RP11-624C23.1_ENST00000523578.1_RNA|RP11-624C23.1_ENST00000519689.1_RNA|ADAM7_ENST00000380789.1_Missense_Mutation_p.T179I|ADAM7_ENST00000441335.2_Missense_Mutation_p.T179I	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	179					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		ACCAGAAAAACTGTTCCAGGG	0.348000													40	59					0	0	1	0	0
TUBGCP3	10426	broad.mit.edu	37	13	113200061	113200061	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:113200061G>A	ENST00000261965.3	-	11	1473	c.1287C>T	c.(1285-1287)ttC>ttT	p.F429F	TUBGCP3_ENST00000375669.3_Silent_p.F429F|TUBGCP3_ENST00000462580.1_5'UTR	NM_006322.4	NP_006313.1	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	429					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|urinary_tract(1)	25	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					AGCGGTACAGGAAGCTCAAAA	0.522000													60	127					0	0	1	0	0
KIF3A	11127	broad.mit.edu	37	5	132051943	132051943	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:132051943G>A	ENST00000378746.4	-	7	1166	c.948C>T	c.(946-948)acC>acT	p.T316T	KIF3A_ENST00000378735.1_Silent_p.T316T|KIF3A_ENST00000403231.1_Silent_p.T316T|AC004237.1_ENST00000431165.1_RNA	NM_007054.5	NP_008985.3	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	316	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			endometrium(1)|kidney(4)|large_intestine(8)|lung(3)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	25		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTACCATCATGGTTTTTGAAT	0.328000													8	23					0	0	1	0	0
ZSCAN5A	79149	broad.mit.edu	37	19	56733418	56733418	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:56733418C>T	ENST00000587340.1	-	7	1712	c.1017G>A	c.(1015-1017)gcG>gcA	p.A339A	ZSCAN5A_ENST00000254165.3_Silent_p.A222A|ZSCAN5A_ENST00000592355.1_Silent_p.A338A|ZSCAN5A_ENST00000587492.1_Silent_p.A193A|ZSCAN5A_ENST00000391713.1_Silent_p.A339A			Q9BUG6	ZSA5A_HUMAN	zinc finger and SCAN domain containing 5A	339					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.A339A(1)		autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(12)|ovary(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						TGACTGGGCTCGCAGGGCCTG	0.552000													14	31					0	0	1	0	0
MYH2	4620	broad.mit.edu	37	17	10430366	10430366	+	Silent	SNP	A	A	G			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:10430366A>G	ENST00000245503.5	-	29	4263	c.3879T>C	c.(3877-3879)ttT>ttC	p.F1293F	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|MYH2_ENST00000397183.2_Silent_p.F1293F|CTC-297N7.7_ENST00000581304.1_RNA|MYH2_ENST00000532183.1_Intron	NM_017534.5	NP_060004.3	Q9UKX2	MYH2_HUMAN	myosin, heavy chain 2, skeletal muscle, adult	1293					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(16)|lung(99)|ovary(6)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(4)	176						GCTGGCGTGAAAACTCACCTG	0.383000													22	12					0	0	1	0	0
ARFGEF2	10564	broad.mit.edu	37	20	47601351	47601351	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:47601351C>T	ENST00000371917.4	+	15	2044	c.2044C>T	c.(2044-2046)Ctg>Ttg	p.L682L		NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	682	SEC7.				exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			AGCCCAATTCCTGCACCAGGA	0.527000													69	116					0	0	1	0	0
PID1	55022	broad.mit.edu	37	2	229890441	229890441	+	Silent	SNP	C	C	T	rs140609082		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:229890441C>T	ENST00000392054.3	-	4	993	c.654G>A	c.(652-654)agG>agA	p.R218R	PID1_ENST00000482518.2_Intron|PID1_ENST00000409462.1_Silent_p.R138R|PID1_ENST00000392055.3_Silent_p.R187R|PID1_ENST00000354069.6_Silent_p.R220R	NM_017933.4	NP_060403.3	Q7Z2X4	PCLI1_HUMAN	phosphotyrosine interaction domain containing 1	220	PID.					cytoplasm				breast(4)|endometrium(3)|large_intestine(5)|lung(8)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	26		Renal(207;0.0112)|all_lung(227;0.0191)|Lung NSC(271;0.0851)|all_hematologic(139;0.104)|Acute lymphoblastic leukemia(138;0.171)		Epithelial(121;3.08e-11)|all cancers(144;2.28e-08)|LUSC - Lung squamous cell carcinoma(224;0.0145)|Lung(261;0.0189)		GGAAAGTCTTCCTGAAGGCCT	0.552000													44	65					0	0	1	0	0
MIA3	375056	broad.mit.edu	37	1	222794551	222794551	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:222794551C>T	ENST00000344922.5	+	2	209	c.184C>T	c.(184-186)Cgt>Tgt	p.R62C	MIA3_ENST00000344441.6_Missense_Mutation_p.R62C|MIA3_ENST00000344507.1_Missense_Mutation_p.R62C|MIA3_ENST00000470521.1_3'UTR	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	62	SH3.				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		CCCGGATTGTCGTTTTGTGAA	0.388000													9	42					0	0	1	0	0
RNF112	7732	broad.mit.edu	37	17	19318512	19318512	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:19318512G>A	ENST00000461366.1	+	11	1503	c.1288G>A	c.(1288-1290)Gaa>Aaa	p.E430K		NM_007148.4	NP_009079.2	Q7Z5V9	Q7Z5V9_HUMAN	ring finger protein 112	430							GTP binding|GTPase activity|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|urinary_tract(1)	12						GCTAGCTCAGGAAATCAAGGT	0.657000													28	14					0	0	1	0	0
SNX19	399979	broad.mit.edu	37	11	130784873	130784873	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:130784873C>T	ENST00000265909.4	-	1	1531	c.962G>A	c.(961-963)gGt>gAt	p.G321D	SNX19_ENST00000539184.1_Intron|SNX19_ENST00000530356.1_Intron|SNX19_ENST00000528555.1_Intron|SNX19_ENST00000533318.1_Intron|SNX19_ENST00000533214.1_Missense_Mutation_p.G321D	NM_014758.2	NP_055573.2	Q92543	SNX19_HUMAN	sorting nexin 19	321					cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(8)|ovary(3)|prostate(1)|skin(6)|urinary_tract(1)	35	all_hematologic(175;0.0597)	Lung NSC(97;0.000272)|all_lung(97;0.000608)|Breast(109;0.000962)|all_neural(223;0.0298)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;0.0195)|Lung(977;0.233)		GCCTGCAGAACCCTCTGGCTC	0.517000													36	52					0	0	1	0	0
ATP6AP2	10159	broad.mit.edu	37	X	40456825	40456825	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:40456825C>T	ENST00000378438.4	+	5	601	c.443C>T	c.(442-444)tCa>tTa	p.S148L	ATP6AP2_ENST00000535777.1_Intron|ATP6AP2_ENST00000544975.1_Missense_Mutation_p.S72L|ATP6AP2_ENST00000535539.1_Missense_Mutation_p.S116L|ATP6AP2_ENST00000486558.1_3'UTR	NM_005765.2	NP_005756.2	O75787	RENR_HUMAN	ATPase, H+ transporting, lysosomal accessory protein 2	148					angiotensin maturation|positive regulation of transforming growth factor-beta1 production|regulation of MAPKKK cascade	external side of plasma membrane|integral to membrane	protein binding|receptor activity			endometrium(1)|large_intestine(1)|lung(2)	4						GAAGACCTTTCAGTCACCTTG	0.408000													41	18					0	0	1	0	0
MYO5B	4645	broad.mit.edu	37	18	47480803	47480803	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:47480803G>A	ENST00000285039.7	-	13	1847	c.1548C>T	c.(1546-1548)gtC>gtT	p.V516V		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	516	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		TTCCTTTGGGGACCTGCAGAA	0.572000													23	41					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43351512	43351512	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:43351512G>A	ENST00000395891.1	+	4	783	c.178G>A	c.(178-180)Ggc>Agc	p.G60S	HECW1_ENST00000453890.1_Missense_Mutation_p.G60S	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	60					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						CCCCCACGATGGCGTCACCAT	0.632000													30	49					0	0	1	0	0
STAP2	55620	broad.mit.edu	37	19	4328767	4328767	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:4328767G>A	ENST00000600324.1	-	6	562	c.495C>T	c.(493-495)ctC>ctT	p.L165L	STAP2_ENST00000594605.1_Silent_p.L165L	NM_017720.2	NP_060190.2	Q9UGK3	STAP2_HUMAN	signal transducing adaptor family member 2	165	SH2.					cytoplasm|nucleus	protein binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)	23		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0339)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCGCTCCAGGAGCAGTTGTG	0.701000													6	6					0	0	1	0	0
P2RY2	5029	broad.mit.edu	37	11	72945775	72945775	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:72945775C>T	ENST00000311131.2	+	3	1038	c.571C>T	c.(571-573)Ctc>Ttc	p.L191F	P2RY2_ENST00000393597.2_Missense_Mutation_p.L191F|P2RY2_ENST00000393596.2_Missense_Mutation_p.L191F	NM_002564.2|NM_176072.1	NP_002555.2|NP_788086.1	P41231	P2RY2_HUMAN	purinergic receptor P2Y, G-protein coupled, 2	191					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25					Suramin(DB04786)	GGCACCCGAGCTCTTCAGCCG	0.662000													17	22					0	0	1	0	0
RDX	5962	broad.mit.edu	37	11	110104137	110104137	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:110104137G>A	ENST00000343115.4	-	13	1731	c.1412C>T	c.(1411-1413)cCt>cTt	p.P471L	RDX_ENST00000544551.1_Missense_Mutation_p.P335L|RDX_ENST00000530301.1_Intron|RDX_ENST00000528498.1_Missense_Mutation_p.P471L|RDX_ENST00000528900.1_Missense_Mutation_p.P124L|RDX_ENST00000405097.1_Missense_Mutation_p.P471L	NM_001260494.1|NM_002906.3	NP_001247423.1|NP_002897.1	P35241	RADI_HUMAN	radixin	471	Glu-rich.|Poly-Pro.				actin filament capping	cleavage furrow|cytoskeleton|extrinsic to membrane|Golgi apparatus|nucleolus|plasma membrane	actin binding			endometrium(3)|kidney(2)|large_intestine(3)|lung(8)|skin(1)|urinary_tract(1)	18		all_cancers(61;7.18e-13)|all_epithelial(67;2.61e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.13e-06)|BRCA - Breast invasive adenocarcinoma(274;9.75e-06)|all cancers(92;5.9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0248)		TGGAGGTGGAGGGGGGGCAGA	0.428000													45	88					0	0	1	0	0
SLITRK1	114798	broad.mit.edu	37	13	84454540	84454540	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:84454540G>A	ENST00000377084.2	-	1	1988	c.1103C>T	c.(1102-1104)gCt>gTt	p.A368V		NM_052910.1	NP_443142.1	Q96PX8	SLIK1_HUMAN	SLIT and NTRK-like family, member 1	368	LRRNT 2.					integral to membrane				NS(2)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(36)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	80	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CTTCAAATCAGCCAAGCTGCT	0.502000													34	64					0	0	1	0	0
AKR1CL1	340811	broad.mit.edu	37	10	5203863	5203863	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:5203863C>T	ENST00000334314.3	-	3	410	c.334G>A	c.(334-336)Gac>Aac	p.D112N						aldo-keto reductase family 1, member C-like 1											cervix(1)|endometrium(1)|large_intestine(2)|lung(2)	6						TCTACATAGTCCGGTCCAAGT	0.418000													11	13					0	0	1	0	0
GLI2	2736	broad.mit.edu	37	2	121743920	121743920	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:121743920C>T	ENST00000452319.1	+	13	2083	c.2023C>T	c.(2023-2025)Ccc>Tcc	p.P675S	GLI2_ENST00000314490.11_Missense_Mutation_p.P347S|GLI2_ENST00000435313.2_3'UTR|GLI2_ENST00000361492.4_Missense_Mutation_p.P675S			P10070	GLI2_HUMAN	GLI family zinc finger 2	675					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				GGGCAGTGCCCCCAACAATGA	0.687000													27	42					0	0	1	0	0
TMPRSS15	5651	broad.mit.edu	37	21	19653490	19653490	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:19653490C>T	ENST00000284885.3	-	22	2568	c.2535G>A	c.(2533-2535)atG>atA	p.M845I		NM_002772.2	NP_002763.2	P98073	ENTK_HUMAN	transmembrane protease, serine 15	845	Peptidase S1.				proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(7)|large_intestine(19)|lung(36)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	85						GATTTGATTTCATATGCAGGC	0.408000													50	76					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36898776	36898776	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:36898776C>T	ENST00000301807.6	-	12	2552	c.655G>A	c.(655-657)Gat>Aat	p.D219N	TRANK1_ENST00000428977.2_Missense_Mutation_p.D219N|TRANK1_ENST00000429976.2_Missense_Mutation_p.D769N	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	769					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TCATCCTGATCATCATTGCCC	0.562000													138	172					0	0	1	0	0
HTRA2	27429	broad.mit.edu	37	2	74757402	74757402	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:74757402C>T	ENST00000258080.3	+	1	899	c.269C>T	c.(268-270)aCc>aTc	p.T90I	HTRA2_ENST00000352222.3_Missense_Mutation_p.T90I|HTRA2_ENST00000467961.1_Intron	NM_013247.4	NP_037379.1	O43464	HTRA2_HUMAN	HtrA serine peptidase 2	90					apoptosis|proteolysis|response to stress	CD40 receptor complex|endoplasmic reticulum membrane|internal side of plasma membrane|mitochondrial intermembrane space|mitochondrial membrane|nucleus	serine-type endopeptidase activity|unfolded protein binding			endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	12						ACCCCAGATACCAGGACCCGG	0.687000													7	12					0	0	1	0	0
SCN5A	6331	broad.mit.edu	37	3	38629035	38629035	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:38629035C>T	ENST00000413689.1	-	15	2485	c.2292G>A	c.(2290-2292)atG>atA	p.M764I	SCN5A_ENST00000425664.1_Missense_Mutation_p.M764I|SCN5A_ENST00000443581.1_Missense_Mutation_p.M764I|SCN5A_ENST00000414099.2_Missense_Mutation_p.M764I|SCN5A_ENST00000450102.2_Missense_Mutation_p.M764I|SCN5A_ENST00000455624.2_Missense_Mutation_p.M764I|SCN5A_ENST00000449557.2_Missense_Mutation_p.M764I|SCN5A_ENST00000423572.2_Missense_Mutation_p.M764I|SCN5A_ENST00000451551.2_Missense_Mutation_p.M764I|SCN5A_ENST00000333535.4_Missense_Mutation_p.M764I	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	764					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TCTTGAAGGTCATCTCTGCTG	0.542000													14	37					0	0	1	0	0
XKR4	114786	broad.mit.edu	37	8	56436024	56436024	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:56436024C>T	ENST00000327381.5	+	3	1291	c.1191C>T	c.(1189-1191)ttC>ttT	p.F397F		NM_052898.1	NP_443130.1	Q5GH76	XKR4_HUMAN	XK, Kell blood group complex subunit-related family, member 4	397						integral to membrane				NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(3)|large_intestine(4)|liver(2)|lung(12)|ovary(1)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	34			Epithelial(17;0.000117)|all cancers(17;0.000836)			CCTCGGTTTTCCAGCTGTACT	0.512000													60	91					0	0	1	0	0
P2RY2	5029	broad.mit.edu	37	11	72945979	72945979	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:72945979C>T	ENST00000311131.2	+	3	1242	c.775C>T	c.(775-777)Ctg>Ttg	p.L259L	P2RY2_ENST00000393597.2_Silent_p.L259L|P2RY2_ENST00000393596.2_Silent_p.L259L	NM_002564.2|NM_176072.1	NP_002555.2|NP_788086.1	P41231	P2RY2_HUMAN	purinergic receptor P2Y, G-protein coupled, 2	259					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25					Suramin(DB04786)	CCTCTGCTTCCTGCCATTCCA	0.642000													32	77					0	0	1	0	0
TRIM55	84675	broad.mit.edu	37	8	67047234	67047234	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:67047234G>A	ENST00000315962.4	+	3	724	c.351G>A	c.(349-351)aaG>aaA	p.K117K	TRIM55_ENST00000353317.5_Silent_p.K117K|TRIM55_ENST00000350034.4_Silent_p.K117K|TRIM55_ENST00000276573.7_Silent_p.K117K	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	117						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			GGCCAGAAAAGAAATCCGACC	0.517000													20	36					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179438775	179438775	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:179438775C>T	ENST00000589042.1	-	326	72308	c.72084G>A	c.(72082-72084)aaG>aaA	p.K24028K	TTN_ENST00000342992.6_Silent_p.K21460K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.K22387K|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Silent_p.K14963K|TTN_ENST00000342175.6_Silent_p.K15155K|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Silent_p.K15088K|TTN-AS1_ENST00000456053.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	22387	Fibronectin type-III 74.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCACCTTTATCTTTGGTGCCT	0.463000													14	44					0	0	1	0	0
SLC5A10	125206	broad.mit.edu	37	17	18923082	18923082	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:18923082G>A	ENST00000317977.6	+	13	1948	c.1377G>A	c.(1375-1377)ctG>ctA	p.L459L	SLC5A10_ENST00000395642.1_Silent_p.L459L|SLC5A10_ENST00000395647.2_Silent_p.L505L|SLC5A10_ENST00000395643.2_Silent_p.L462L|SLC5A10_ENST00000395645.3_Silent_p.L489L|SLC5A10_ENST00000417251.2_Silent_p.L453L			A0PJK1	SC5AA_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 10	489					sodium ion transport|transmembrane transport	integral to membrane	transporter activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(3)|ovary(3)|prostate(3)|skin(3)	24						GGCTGGTCCTGGAATTCCTGA	0.682000													17	3					0	0	1	0	0
ZNF490	57474	broad.mit.edu	37	19	12692189	12692189	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:12692189G>A	ENST00000311437.6	-	5	822	c.700C>T	c.(700-702)Ctc>Ttc	p.L234F		NM_020714.2	NP_065765.1	Q9ULM2	ZN490_HUMAN	zinc finger protein 490	234					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|urinary_tract(1)	18						AAGGAAAAGAGAAATGCGAAG	0.433000													8	30					0	0	1	0	0
ZNF414	84330	broad.mit.edu	37	19	8576706	8576706	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:8576706G>A	ENST00000393927.4	-	5	782	c.669C>T	c.(667-669)ccC>ccT	p.P223P	ZNF414_ENST00000255616.8_Silent_p.P223P	NM_001146175.1	NP_001139647.1	Q96IQ9	ZN414_HUMAN	zinc finger protein 414	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(2)	2						CAACCTCCGGGGGGCGCTCCG	0.746000													5	3					0	0	1	0	0
GPR116	221395	broad.mit.edu	37	6	46826916	46826916	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:46826916G>A	ENST00000283296.7	-	17	3012	c.2724C>T	c.(2722-2724)atC>atT	p.I908I	GPR116_ENST00000265417.7_Silent_p.I908I|GPR116_ENST00000362015.4_Silent_p.I908I|GPR116_ENST00000456426.2_Silent_p.I766I|GPR116_ENST00000545669.1_Silent_p.I337I	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	908					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			CCTGGGCAAGGATGGCTTGGA	0.448000													34	57					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12957987	12957987	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:12957987G>A	ENST00000276297.4	-	9	2268	c.1859C>T	c.(1858-1860)tCc>tTc	p.S620F	DLC1_ENST00000358919.2_Missense_Mutation_p.S183F|DLC1_ENST00000520226.1_Missense_Mutation_p.S109F|DLC1_ENST00000512044.2_Missense_Mutation_p.S217F	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	620					actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						GCTGATGACGGAGTTAGTCCG	0.642000													26	102					0	0	1	0	0
NLRP14	338323	broad.mit.edu	37	11	7083593	7083593	+	Missense_Mutation	SNP	G	G	A	rs139902169		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:7083593G>A	ENST00000299481.4	+	10	3180	c.2834G>A	c.(2833-2835)tGt>tAt	p.C945Y		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	945					cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		ACTAATGCATGTTGTCTGGAT	0.398000													29	54					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26219498	26219498	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:26219498G>A	ENST00000335473.7	+	13	2798	c.2548G>A	c.(2548-2550)Gag>Aag	p.E850K	MYO18B_ENST00000407587.2_Missense_Mutation_p.E850K|MYO18B_ENST00000536101.1_Missense_Mutation_p.E850K	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	850	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CATGAGGTTTGAGTGGGCAAA	0.572000													41	64					0	0	1	0	0
SRPR	6734	broad.mit.edu	37	11	126134947	126134947	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:126134947G>A	ENST00000332118.6	-	11	1586	c.1432C>T	c.(1432-1434)Cca>Tca	p.P478S	SRPR_ENST00000532259.1_Missense_Mutation_p.P450S	NM_003139.3	NP_003130.2	P08240	SRPR_HUMAN	signal recognition particle receptor (docking protein)	478					SRP-dependent cotranslational protein targeting to membrane	integral to membrane|signal recognition particle receptor complex	GTP binding|GTPase activity|receptor activity|signal recognition particle binding			endometrium(7)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)	21	all_hematologic(175;0.145)			BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0736)		TGCTTCTCTGGAGGGTGTAGG	0.552000													12	24					0	0	1	0	0
FAF1	11124	broad.mit.edu	37	1	51121201	51121201	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:51121201C>T	ENST00000396153.2	-	8	1109		c.e8-1		FAF1_ENST00000371778.4_Splice_Site	NM_007051.2	NP_008982.1	Q9UNN5	FAF1_HUMAN	Fas (TNFRSF6) associated factor 1						apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity	p.0?(1)		breast(2)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|pancreas(2)|upper_aerodigestive_tract(1)	24				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		TTCTCTTTACCTATGAAAAGA	0.378000													6	41					0	0	1	0	0
TMEM178A	130733	broad.mit.edu	37	2	39893167	39893167	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:39893167C>T	ENST00000281961.2	+	1	109	c.53C>T	c.(52-54)tCc>tTc	p.S18F	TMEM178A_ENST00000482239.1_Intron	NM_152390.2	NP_689603.2			transmembrane protein 178A																		AGCCTGTGCTCCCTGGGGCTG	0.766000													7	6					0	0	1	0	0
NRF1	4899	broad.mit.edu	37	7	129349024	129349024	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:129349024C>T	ENST00000393232.1	+	6	833	c.716C>T	c.(715-717)cCc>cTc	p.P239L	NRF1_ENST00000393231.3_Missense_Mutation_p.P239L|NRF1_ENST00000223190.4_Missense_Mutation_p.P239L|NRF1_ENST00000539636.1_Missense_Mutation_p.P78L|NRF1_ENST00000311967.2_Missense_Mutation_p.P239L|NRF1_ENST00000353868.4_Missense_Mutation_p.P239L|NRF1_ENST00000393230.2_Missense_Mutation_p.P239L	NM_005011.3	NP_005002.3	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	239					generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)	24						GAAGATATCCCCTGGGCAAAT	0.517000													67	109					0	0	1	0	0
MANSC1	54682	broad.mit.edu	37	12	12483131	12483131	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:12483131G>A	ENST00000535902.1	-	4	1689	c.1126C>T	c.(1126-1128)Cag>Tag	p.Q376*	MANSC1_ENST00000396349.3_Nonsense_Mutation_p.Q342*|MANSC1_ENST00000545735.1_Nonsense_Mutation_p.Q295*			Q9H8J5	MANS1_HUMAN	MANSC domain containing 1	376						integral to membrane				breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|skin(1)|stomach(4)	23		Prostate(47;0.0865)		BRCA - Breast invasive adenocarcinoma(232;0.185)		AGGCCGTACTGATTTTCTGGA	0.507000													15	40					0	0	1	0	0
RAI2	10742	broad.mit.edu	37	X	17819456	17819456	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:17819456G>A	ENST00000545871.1	-	3	1135	c.675C>T	c.(673-675)gtC>gtT	p.V225V	RAI2_ENST00000415486.3_Silent_p.V175V|RAI2_ENST00000360011.1_Silent_p.V225V|RAI2_ENST00000331511.1_Silent_p.V225V|RAI2_ENST00000451717.1_Silent_p.V225V	NM_001172739.1|NM_001172743.1	NP_001166210.1|NP_001166214.1	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	225	Pro-rich.				embryo development					breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	22	Hepatocellular(33;0.183)					TGGCTGGTGGGACCAGGGGGG	0.632000													31	5					0	0	1	0	0
SH3RF2	153769	broad.mit.edu	37	5	145317863	145317863	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:145317863G>A	ENST00000511217.1	+	1	424	c.372G>A	c.(370-372)atG>atA	p.M124I	SH3RF2_ENST00000359120.4_Missense_Mutation_p.M124I			Q8TEC5	SH3R2_HUMAN	SH3 domain containing ring finger 2	124							ligase activity|protein phosphatase 1 binding|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|skin(2)|stomach(1)	22			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAATCCACATGGATGGGGTAA	0.463000													12	36					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120465314	120465314	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:120465314G>A	ENST00000256646.2	-	27	5166	c.4947C>T	c.(4945-4947)ctC>ctT	p.L1649L	NOTCH2_ENST00000493703.1_5'UTR	NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	1649	Negative regulatory region (NRR).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAGAGGCCAGGAGAGCTGCTG	0.547000			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				31	159					0	0	1	0	0
PEMT	10400	broad.mit.edu	37	17	17409590	17409590	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:17409590G>A	ENST00000395781.2	-	7	716	c.635C>T	c.(634-636)cCt>cTt	p.P212L	PEMT_ENST00000435340.2_Missense_Mutation_p.P191L|PEMT_ENST00000395782.1_Silent_p.L165L|PEMT_ENST00000484838.2_5'UTR|PEMT_ENST00000255389.5_Silent_p.L202L|PEMT_ENST00000395783.1_Silent_p.L165L	NM_001267552.1	NP_001254481.1	Q9UBM1	PEMT_HUMAN	phosphatidylethanolamine N-methyltransferase	0					cell proliferation|phosphatidylcholine biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial membrane	phosphatidylethanolamine N-methyltransferase activity			endometrium(1)|kidney(1)|large_intestine(2)|prostate(3)	7				Colorectal(2;0.0157)|READ - Rectum adenocarcinoma(2;0.0891)		AGCACCGTCAGGAGCAGGCCC	0.692000													8	1					0	0	1	0	0
GRM2	2912	broad.mit.edu	37	3	51743007	51743007	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:51743007C>T	ENST00000395052.3	+	2	242	c.8C>T	c.(7-9)tCg>tTg	p.S3L	GRM2_ENST00000475478.1_Intron|GRM2_ENST00000442933.2_Missense_Mutation_p.S3L	NM_000839.3	NP_000830.2	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2	3					synaptic transmission	integral to plasma membrane		p.S3L(1)		breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(11)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GCCATGGGATCGCTGCTTGCG	0.632000													13	15					0	0	1	0	0
INCA1	388324	broad.mit.edu	37	17	4893552	4893552	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:4893552C>T	ENST00000396829.2	-	5	619	c.53G>A	c.(52-54)aGg>aAg	p.R18K	INCA1_ENST00000355025.3_Missense_Mutation_p.R18K|INCA1_ENST00000574617.1_Missense_Mutation_p.R18K|INCA1_ENST00000576820.1_Missense_Mutation_p.R18K|INCA1_ENST00000575780.1_Missense_Mutation_p.R18K	NM_001167986.1	NP_001161458.1	Q0VD86	INCA1_HUMAN	inhibitor of CDK, cyclin A1 interacting protein 1	18						nucleus				upper_aerodigestive_tract(1)	1						GCTGACCACCCTGGAACACCT	0.557000													25	10					0	0	1	0	0
FAM212B	55924	broad.mit.edu	37	1	112269701	112269701	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:112269701G>A	ENST00000357260.5	-	2	964	c.783C>T	c.(781-783)ccC>ccT	p.P261P	FAM212B_ENST00000444059.2_Silent_p.P246P|FAM212B_ENST00000534365.1_Intron	NM_019099.4	NP_061972.1	Q9NTI7	CA183_HUMAN	family with sequence similarity 212, member B	261										cervix(1)|endometrium(1)	2						TGCCTGGGAAGGGGAAATGTC	0.612000													30	190					0	0	1	0	0
C4orf32	132720	broad.mit.edu	37	4	113108007	113108007	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:113108007C>T	ENST00000309733.4	+	2	496	c.312C>T	c.(310-312)ttC>ttT	p.F104F		NM_152400.2	NP_689613.1	Q8N8J7	CD032_HUMAN	chromosome 4 open reading frame 32	104						integral to membrane							Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.00198)		TAGTCATTTTCTTTTGGGTTA	0.403000													97	61					0	0	1	0	0
ZNF638	27332	broad.mit.edu	37	2	71576784	71576784	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:71576784C>T	ENST00000409544.1	+	2	1330	c.700C>T	c.(700-702)Cca>Tca	p.P234S	ZNF638_ENST00000264447.4_Missense_Mutation_p.P234S|ZNF638_ENST00000377802.2_Missense_Mutation_p.P234S|ZNF638_ENST00000355812.3_Missense_Mutation_p.P234S|ZNF638_ENST00000410075.1_3'UTR	NM_001252612.1	NP_001239541.1	Q14966	ZN638_HUMAN	zinc finger protein 638	234					RNA splicing	cytoplasm|nuclear speck	double-stranded DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|lung(28)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|urinary_tract(1)	63						TCCTGAAATTCCAACTGATGA	0.378000													34	54					0	0	1	0	0
SEZ6L2	26470	broad.mit.edu	37	16	29907160	29907160	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:29907160G>A	ENST00000308713.5	-	4	1060	c.533C>T	c.(532-534)tCc>tTc	p.S178F	SEZ6L2_ENST00000350527.3_Missense_Mutation_p.S108F|SEZ6L2_ENST00000346932.5_Intron|SEZ6L2_ENST00000562159.1_Intron|SEZ6L2_ENST00000537485.1_Missense_Mutation_p.S134F	NM_001114099.2|NM_201575.3	NP_001107571.1|NP_963869.2	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2	178	CUB 1.					endoplasmic reticulum membrane|integral to membrane|plasma membrane				breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TTCGCCCTCGGAGATGTTGTT	0.562000													34	61					0	0	1	0	0
LGR6	59352	broad.mit.edu	37	1	202287272	202287272	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:202287272C>T	ENST00000367278.3	+	18	1930	c.1841C>T	c.(1840-1842)tCc>tTc	p.S614F	LGR6_ENST00000439764.2_Missense_Mutation_p.S475F|LGR6_ENST00000255432.7_Missense_Mutation_p.S562F	NM_001017403.1	NP_001017403.1	Q9HBX8	LGR6_HUMAN	leucine-rich repeat containing G protein-coupled receptor 6	614						integral to membrane|plasma membrane	protein-hormone receptor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(16)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	36						ACTGGCATTTCCTGTGGCCTT	0.637000													35	12					0	0	1	0	0
CAPN5	726	broad.mit.edu	37	11	76796028	76796028	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:76796028C>T	ENST00000278559.3	+	2	285	c.96C>T	c.(94-96)ttC>ttT	p.F32F	CAPN5_ENST00000531028.1_Silent_p.F32F|CAPN5_ENST00000456580.2_Silent_p.F32F|CAPN5_ENST00000529629.1_Silent_p.F32F	NM_004055.4	NP_004046.2	O15484	CAN5_HUMAN	calpain 5	32	Calpain catalytic.				proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity			NS(1)|breast(2)|endometrium(2)|large_intestine(7)|lung(17)|urinary_tract(1)	30						ACCCCCTCTTCCCCGCCACTG	0.637000													11	19					0	0	1	0	0
SLIT1	6585	broad.mit.edu	37	10	98778824	98778824	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:98778824G>A	ENST00000266058.4	-	27	3032	c.2787C>T	c.(2785-2787)tgC>tgT	p.C929C	ARHGAP19-SLIT1_ENST00000453547.2_3'UTR|SLIT1_ENST00000371070.4_Silent_p.C929C	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	929	EGF-like 1.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		GACTGGACAAGCAGAGATCAC	0.647000													23	11					0	0	1	0	0
NID2	22795	broad.mit.edu	37	14	52493942	52493942	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:52493942G>A	ENST00000216286.5	-	12	2650	c.2651C>T	c.(2650-2652)gCc>gTc	p.A884V	NID2_ENST00000541773.1_Intron	NM_007361.3	NP_031387.3	Q14112	NID2_HUMAN	nidogen 2 (osteonidogen)	884	EGF-like 4.					basement membrane	calcium ion binding|collagen binding			NS(1)|breast(5)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(40)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	87	Breast(41;0.0639)|all_epithelial(31;0.123)					CCCATCGCCGGCATAACCAGG	0.587000													9	1					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154189432	154189432	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:154189432C>T	ENST00000360256.4	-	10	1655	c.1455G>A	c.(1453-1455)aaG>aaA	p.K485K		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	485	F5/8 type A 2.|Plastocyanin-like 3.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTGCTTGATTCTTAAATATAA	0.358000													9	1					0	0	1	0	0
FAM213A	84293	broad.mit.edu	37	10	82182205	82182205	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:82182205G>A	ENST00000372181.1	+	2	681	c.211G>A	c.(211-213)Gaa>Aaa	p.E71K	FAM213A_ENST00000372185.1_Missense_Mutation_p.E60K|FAM213A_ENST00000372187.5_Missense_Mutation_p.E71K|FAM213A_ENST00000372188.1_Missense_Mutation_p.E71K	NM_001243778.1|NM_001243782.1	NP_001230707.1|NP_001230711.1	Q9BRX8	CJ058_HUMAN	family with sequence similarity 213, member A	71						extracellular region											GGAGCTATGGGAAAAAAATGG	0.483000													15	31					0	0	1	0	0
WDR38	401551	broad.mit.edu	37	9	127619824	127619824	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:127619824G>A	ENST00000373574.1	+	9	916	c.860G>A	c.(859-861)gGg>gAg	p.G287E		NM_001045476.1|NM_001276374.1	NP_001038941.1|NP_001263303.1	Q5JTN6	WDR38_HUMAN	WD repeat domain 38	287										breast(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	8						ACCCCAGATGGGAAAATCTTA	0.552000													23	11					0	0	1	0	0
GRXCR1	389207	broad.mit.edu	37	4	42895324	42895324	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:42895324G>A	ENST00000399770.2	+	1	41	c.41G>A	c.(40-42)cGg>cAg	p.R14Q		NM_001080476.2	NP_001073945.1	A8MXD5	GRCR1_HUMAN	glutaredoxin, cysteine rich 1	14					cell redox homeostasis|inner ear receptor stereocilium organization|sensory perception of sound|vestibular receptor cell development	kinocilium|stereocilium	electron carrier activity|protein disulfide oxidoreductase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(22)|ovary(1)|prostate(2)|skin(1)	32						GACAGGCCACGGAAAGTCCGG	0.512000													23	77					0	0	1	0	0
IL1B	3553	broad.mit.edu	37	2	113588124	113588124	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:113588124C>T	ENST00000263341.2	-	7	834	c.624G>A	c.(622-624)aaG>aaA	p.K208K	IL1B_ENST00000491056.1_5'UTR	NM_000576.2	NP_000567.1	P01584	IL1B_HUMAN	interleukin 1, beta	208					activation of MAPK activity|anti-apoptosis|apoptosis|cell-cell signaling|cellular response to drug|cellular response to mechanical stimulus|cytokine-mediated signaling pathway|embryo implantation|fever generation|negative regulation of adiponectin secretion|negative regulation of cell proliferation|negative regulation of glucose transport|negative regulation of insulin receptor signaling pathway|negative regulation of lipid catabolic process|negative regulation of MAP kinase activity|positive regulation of angiogenesis|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of cell adhesion molecule production|positive regulation of cell division|positive regulation of fever generation|positive regulation of granulocyte macrophage colony-stimulating factor production|positive regulation of heterotypic cell-cell adhesion|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of interferon-gamma production|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of lipid catabolic process|positive regulation of membrane protein ectodomain proteolysis|positive regulation of mitosis|positive regulation of monocyte chemotactic protein-1 production|positive regulation of myosin light chain kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin secretion|positive regulation of protein export from nucleus|positive regulation of T cell proliferation|positive regulation vascular endothelial growth factor production|regulation of insulin secretion|sequestering of triglyceride|smooth muscle adaptation	cytosol|extracellular space	cytokine activity|growth factor activity|interleukin-1 receptor binding|protein domain specific binding			breast(2)|central_nervous_system(1)|large_intestine(1)|lung(8)	12					Anakinra(DB00026)|Minocycline(DB01017)|Procaterol(DB01366)	CCATCTTCTTCTTTGGGTAAT	0.418000													45	64					0	0	1	0	0
IL1R2	7850	broad.mit.edu	37	2	102626066	102626066	+	Missense_Mutation	SNP	G	G	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:102626066G>C	ENST00000332549.3	+	3	339	c.110G>C	c.(109-111)cGg>cCg	p.R37P	IL1R2_ENST00000393414.2_Missense_Mutation_p.R37P|IL1R2_ENST00000441002.1_Missense_Mutation_p.R37P	NM_004633.3	NP_004624.1	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II	37	Ig-like C2-type 1.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity	p.R37L(1)		breast(3)|endometrium(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|skin(1)	28					Anakinra(DB00026)	CATTACAAGCGGGAGTTCAGG	0.592000													77	137					0	0	1	0	0
STAB2	55576	broad.mit.edu	37	12	104078786	104078786	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:104078786C>T	ENST00000388887.2	+	27	3125	c.2921C>T	c.(2920-2922)tCg>tTg	p.S974L		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	974	EGF-like 10.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						CAATCTACTTCGTCTGGTGTC	0.453000													42	39					0	0	1	0	0
CDX4	1046	broad.mit.edu	37	X	72667275	72667275	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:72667275G>A	ENST00000373514.2	+	1	186	c.186G>A	c.(184-186)atG>atA	p.M62I		NM_005193.1	NP_005184.1	O14627	CDX4_HUMAN	caudal type homeobox 4	62						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|skin(1)	18	Renal(35;0.156)					TGCCCAGCATGGATCCTCACT	0.622000													19	3					0	0	1	0	0
TNNI3	7137	broad.mit.edu	37	19	55668486	55668486	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:55668486G>A	ENST00000344887.5	-	3	182	c.40C>T	c.(40-42)Cct>Tct	p.P14S	CTD-2587H24.4_ENST00000587871.1_3'UTR|TNNI3_ENST00000590463.1_5'UTR	NM_000363.4	NP_000354.4	P19429	TNNI3_HUMAN	troponin I type 3 (cardiac)	14					cardiac muscle contraction|cellular calcium ion homeostasis|muscle filament sliding|negative regulation of ATPase activity|regulation of systemic arterial blood pressure by ischemic conditions|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|calcium channel inhibitor activity|calcium-dependent protein binding|protein domain specific binding|protein kinase binding|troponin C binding|troponin T binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|pancreas(1)|urinary_tract(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		GCTGGTGCAGGGCGAGGTTCC	0.667000													4	5					0	0	1	0	0
PRR23C	389152	broad.mit.edu	37	3	138762806	138762806	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:138762806G>A	ENST00000413199.1	-	1	928	c.657C>T	c.(655-657)ttC>ttT	p.F219F	MRPS22_ENST00000495075.1_Intron|PRR23C_ENST00000502927.2_Silent_p.F219F	NM_001134657.1	NP_001128129.1	Q6ZRP0	PR23C_HUMAN	proline rich 23C	219	Pro-rich.									breast(2)|lung(7)|skin(2)	11						CCAGAAGATGGAATTCCAGGT	0.672000													8	15					0	0	1	0	0
GPR50	9248	broad.mit.edu	37	X	150348412	150348412	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:150348412C>T	ENST00000218316.3	+	2	426	c.357C>T	c.(355-357)atC>atT	p.I119I		NM_004224.3	NP_004215.2	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	119					cell-cell signaling	integral to plasma membrane	melatonin receptor activity			breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)	38	Acute lymphoblastic leukemia(192;6.56e-05)					TCTTCAACATCGTGGCAATCG	0.542000													69	13					0	0	1	0	0
BCR	613	broad.mit.edu	37	22	23603672	23603672	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr22:23603672C>T	ENST00000305877.8	+	4	2448	c.1697C>T	c.(1696-1698)cCc>cTc	p.P566L	BCR_ENST00000359540.3_Missense_Mutation_p.P566L	NM_004327.3	NP_004318.3	P11274	BCR_HUMAN	breakpoint cluster region	566	DH.				regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	ATP binding|GTPase activator activity|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity		BCR/JAK2(6)	central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	35						GGGCTCTTCCCCCGCGTGCAG	0.602000			T	"""ABL1,  FGFR1, JAK2 """	"""CML, ALL, AML"""								41	58					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100349367	100349367	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:100349367C>T	ENST00000542585.1	+	0	1787				ZAN_ENST00000348028.3_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TCCCGTATCTCCAGTTTCTTC	0.453000													28	32					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55540643	55540643	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:55540643C>T	ENST00000220676.1	+	4	4349	c.4201C>T	c.(4201-4203)Ctt>Ttt	p.L1401F		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1401					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			CTCCTGTGGCCTTTGCCTAAG	0.318000													23	25					0	0	1	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47333651	47333651	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:47333651C>T	ENST00000505841.1	-	0	1037					NR_002788.2																						CTAGGAGTTCCCTGATTTCAT	0.428000													5	30					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32020739	32020739	+	Silent	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:32020739T>C	ENST00000375244.3	-	26	9024	c.8823A>G	c.(8821-8823)gaA>gaG	p.E2941E	TNXB_ENST00000375247.2_Silent_p.E2939E			P22105	TENX_HUMAN	tenascin XB	2986	Fibronectin type-III 21.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CCGTGCTGGGTTCTGTGGGGG	0.642000													22	44					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88886007	88886007	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:88886007C>T	ENST00000319675.3	-	1	289	c.193G>A	c.(193-195)Gat>Aat	p.D65N		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	65										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						GAGGAGGGATCCCAGCTATGA	0.517000													40	67					0	0	1	0	0
OR1L1	26737	broad.mit.edu	37	9	125424618	125424618	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:125424618G>A	ENST00000373686.1	+	1	774	c.774G>A	c.(772-774)atG>atA	p.M258I				Q8NH94	OR1L1_HUMAN	olfactory receptor, family 1, subfamily L, member 1	258					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)	17						CTGTCATAATGACCCCGTTTT	0.403000													54	29					0	0	1	0	0
DNASE1L3	1776	broad.mit.edu	37	3	58186744	58186744	+	Missense_Mutation	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr3:58186744T>C	ENST00000483681.1	-	7	1107	c.526A>G	c.(526-528)Aaa>Gaa	p.K176E	DNASE1L3_ENST00000486455.1_Missense_Mutation_p.K146E|DNASE1L3_ENST00000318316.3_Missense_Mutation_p.K176E|DNASE1L3_ENST00000394549.2_Missense_Mutation_p.K176E			Q13609	DNSL3_HUMAN	deoxyribonuclease I-like 3	176					apoptosis|DNA catabolic process	nucleus	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			breast(2)|large_intestine(4)|lung(6)	12				BRCA - Breast invasive adenocarcinoma(55;0.00021)|KIRC - Kidney renal clear cell carcinoma(284;0.0445)|Kidney(284;0.0556)|OV - Ovarian serous cystadenocarcinoma(275;0.202)		CAGCGGTGTTTCACGTCCGTG	0.552000													10	198					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1272003	1272003	+	Silent	SNP	A	A	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:1272003A>C	ENST00000447027.1	+	31	13960	c.13902A>C	c.(13900-13902)acA>acC	p.T4634T	MUC5B_ENST00000529681.1_Silent_p.T4631T			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	4631	23 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		ccacacccacaaccagtggct	0.652000													36	62					0	0	1	0	0
F11	2160	broad.mit.edu	37	4	187197491	187197491	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:187197491C>T	ENST00000264692.4	+	7	879	c.546C>T	c.(544-546)ccC>ccT	p.P182P	F11_ENST00000403665.2_Silent_p.P234P			P03951	FA11_HUMAN	coagulation factor XI	234	Apple 2.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(15)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	32		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	CTCATCATCCCGGTTGCTTGT	0.423000													14	58					0	0	1	0	0
DNAI1	27019	broad.mit.edu	37	9	34490385	34490385	+	Missense_Mutation	SNP	G	G	A	rs141157671		TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:34490385G>A	ENST00000242317.4	+	7	691	c.520G>A	c.(520-522)Gaa>Aaa	p.E174K	DNAI1_ENST00000488369.1_3'UTR	NM_012144.2	NP_036276.1	Q9UI46	DNAI1_HUMAN	dynein, axonemal, intermediate chain 1	174					cell projection organization	cilium axoneme|cytoplasm|dynein complex|microtubule	motor activity			autonomic_ganglia(1)|endometrium(7)|kidney(1)|large_intestine(8)|lung(13)|prostate(1)|skin(2)|urinary_tract(1)	34	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)|STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.0222)		AAAAGTGACTGAAGAAGAATT	0.498000									Kartagener syndrome				93	30					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50918051	50918051	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:50918051C>T	ENST00000442544.2	+	17	3098	c.2482C>T	c.(2482-2484)Cct>Tct	p.P828S	DCC_ENST00000581580.1_Intron|DCC_ENST00000412726.1_Intron	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	828					apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TGATTATTATCCTTTGCTTGA	0.428000													13	82					0	0	1	0	0
LRP1	4035	broad.mit.edu	37	12	57569798	57569798	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:57569798C>T	ENST00000243077.3	+	24	4366	c.3900C>T	c.(3898-3900)atC>atT	p.I1300I		NM_002332.2	NP_002323.2	Q07954	LRP1_HUMAN	low density lipoprotein receptor-related protein 1	1300					aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(33)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(26)|lung(58)|ovary(10)|pancreas(2)|prostate(11)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	184				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	GCAACACCATCGCCCTGGACT	0.597000											OREG0021937	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	23	76					0	0	1	0	0
CYP1A2	1544	broad.mit.edu	37	15	75044515	75044515	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:75044515C>T	ENST00000343932.4	+	5	1156	c.1093C>T	c.(1093-1095)Ctg>Ttg	p.L365L		NM_000761.3	NP_000752.2	P05177	CP1A2_HUMAN	cytochrome P450, family 1, subfamily A, polypeptide 2	365					alkaloid metabolic process|exogenous drug catabolic process|methylation|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative deethylation|oxidative demethylation|steroid catabolic process|toxin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|demethylase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	33					Acenocoumarol(DB01418)|Acetaminophen(DB00316)|Aciclovir(DB00787)|Alosetron(DB00969)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Anagrelide(DB00261)|Azelastine(DB00972)|Bortezomib(DB00188)|Caffeine(DB00201)|Carmustine(DB00262)|Chlordiazepoxide(DB00475)|Chlorpromazine(DB00477)|Chlorzoxazone(DB00356)|Cimetidine(DB00501)|Cinacalcet(DB01012)|Ciprofloxacin(DB00537)|Clomipramine(DB01242)|Clotrimazole(DB00257)|Clozapine(DB00363)|Conjugated Estrogens(DB00286)|Cyclobenzaprine(DB00924)|Dacarbazine(DB00851)|Desloratadine(DB00967)|Diazepam(DB00829)|Dibucaine(DB00527)|Diclofenac(DB00586)|Duloxetine(DB00476)|Enoxacin(DB00467)|Esomeprazole(DB00736)|Estradiol(DB00783)|Estrone(DB00655)|Fluorouracil(DB00544)|Flutamide(DB00499)|Fluvoxamine(DB00176)|Frovatriptan(DB00998)|Grepafloxacin(DB00365)|Haloperidol(DB00502)|Hesperetin(DB01094)|Imipramine(DB00458)|Ketoconazole(DB01026)|Leflunomide(DB01097)|Levobupivacaine(DB01002)|Levofloxacin(DB01137)|Lidocaine(DB00281)|Lomefloxacin(DB00978)|Melatonin(DB01065)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mirtazapine(DB00370)|Norfloxacin(DB01059)|Nortriptyline(DB00540)|Ofloxacin(DB01165)|Olanzapine(DB00334)|Ondansetron(DB00904)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Pefloxacin(DB00487)|Pimozide(DB01100)|Propafenone(DB01182)|Propranolol(DB00571)|Quinidine(DB00908)|Ramelteon(DB00980)|Ranitidine(DB00863)|Rasagiline(DB01367)|Rifampin(DB01045)|Riluzole(DB00740)|Rofecoxib(DB00533)|Ropinirole(DB00268)|Ropivacaine(DB00296)|Tacrine(DB00382)|Telithromycin(DB00976)|Terfenadine(DB00342)|Theophylline(DB00277)|Thiabendazole(DB00730)|Tizanidine(DB00697)|Tolbutamide(DB01124)|Verapamil(DB00661)|Warfarin(DB00682)|Zileuton(DB00744)|Zolmitriptan(DB00315)	CAGACCCCAGCTGCCCTACTT	0.632000													39	115					0	0	1	0	0
MRGPRX2	117194	broad.mit.edu	37	11	19077101	19077101	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:19077101G>A	ENST00000329773.2	-	2	936	c.849C>T	c.(847-849)ggC>ggT	p.G283G		NM_054030.2	NP_473371.1	Q96LB1	MRGX2_HUMAN	MAS-related GPR, member X2	283					sensory perception of pain|sleep	plasma membrane	G-protein coupled receptor activity|neuropeptide binding			NS(1)|large_intestine(2)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|urinary_tract(1)	15						TCCTAAAAGAGCCCACGAAGA	0.498000													39	60					0	0	1	0	0
PTBP2	58155	broad.mit.edu	37	1	97250671	97250671	+	Silent	SNP	C	C	T	rs142842336	byFrequency	TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:97250671C>T	ENST00000236228.6	+	8	847	c.765C>T	c.(763-765)tcC>tcT	p.S255S	PTBP2_ENST00000394184.3_Silent_p.S266S|PTBP2_ENST00000370198.1_Silent_p.S255S|PTBP2_ENST00000370197.1_Silent_p.S255S|PTBP2_ENST00000426398.2_Silent_p.S255S|PTBP2_ENST00000482253.1_3'UTR|PTBP2_ENST00000541987.1_Silent_p.S224S	NM_021190.2	NP_067013.1	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	255	RRM 2.						nucleotide binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|skin(1)	26		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		TTGATTTTTCCAAACTTGTGA	0.363000													40	14					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216498891	216498891	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:216498891G>A	ENST00000366943.2	-	6	1285	c.899C>T	c.(898-900)tCa>tTa	p.S300L	USH2A_ENST00000366942.3_Missense_Mutation_p.S300L|USH2A_ENST00000307340.3_Missense_Mutation_p.S300L			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	300	Laminin N-terminal.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		ACGGCAATGTGATTGGGCATG	0.502000										HNSCC(13;0.011)			52	25					0	0	1	0	0
RIF1	55183	broad.mit.edu	37	2	152320961	152320961	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:152320961C>T	ENST00000243326.4	+	29	5410	c.4927C>T	c.(4927-4929)Cct>Tct	p.P1643S	RIF1_ENST00000444746.2_Missense_Mutation_p.P1643S|RIF1_ENST00000428287.2_Missense_Mutation_p.P1643S|RIF1_ENST00000453091.2_Missense_Mutation_p.P1643S|RIF1_ENST00000430328.2_Missense_Mutation_p.P1643S			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	1643					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		GTTGCAAGTTCCTGATGATTT	0.338000													8	20					0	0	1	0	0
ANO5	203859	broad.mit.edu	37	11	22225352	22225352	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:22225352G>A	ENST00000324559.8	+	2	360	c.43G>A	c.(43-45)Gaa>Aaa	p.E15K		NM_001142649.1|NM_213599.2	NP_001136121.1|NP_998764.1	Q75V66	ANO5_HUMAN	anoctamin 5	15						chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(12)|lung(36)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TAATTTAGGGGAAAAAGTCAA	0.269000													3	10					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33330826	33330826	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:33330826G>A	ENST00000374796.2	-	12	5804	c.3234C>T	c.(3232-3234)gtC>gtT	p.V1078V	NCOA6_ENST00000359003.2_Silent_p.V1078V			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1078	NCOA1-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						GACTGACCATGACAGGCACAC	0.527000													20	134					0	0	1	0	0
MYO9A	4649	broad.mit.edu	37	15	72172100	72172100	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:72172100G>A	ENST00000356056.5	-	30	6173	c.5701C>T	c.(5701-5703)Cgg>Tgg	p.R1901W	MYO9A_ENST00000444904.1_Missense_Mutation_p.R1882W|MYO9A_ENST00000424560.1_Missense_Mutation_p.R1972W|MYO9A_ENST00000564571.1_Missense_Mutation_p.R1901W	NM_006901.3	NP_008832.2	B2RTY4	MYO9A_HUMAN	myosin IXA	1901	Tail.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction|visual perception	cytosol|integral to membrane|unconventional myosin complex	actin binding|ATP binding|GTPase activator activity|metal ion binding|motor activity			NS(4)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(29)|lung(27)|ovary(1)|pancreas(1)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	88						ATATTCTGCCGAAATTCCTTC	0.378000													27	24					0	0	1	0	0
TSIX	9383	broad.mit.edu	37	X	73043728	73043728	+	RNA	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:73043728C>T	ENST00000604411.1	+	0	31689				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						ATTTTTATATCCTAGGGCATG	0.358000													12	3					0	0	1	0	0
HEPH	9843	broad.mit.edu	37	X	65423252	65423252	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:65423252G>A	ENST00000519389.1	+	13	2465	c.2286G>A	c.(2284-2286)ggG>ggA	p.G762G	HEPH_ENST00000441993.2_Silent_p.G711G|HEPH_ENST00000336279.5_Silent_p.G441G|HEPH_ENST00000374727.3_Silent_p.G711G|HEPH_ENST00000343002.2_Silent_p.G708G|HEPH_ENST00000419594.1_Silent_p.G519G			Q9BQS7	HEPH_HUMAN	hephaestin	708	Plastocyanin-like 5.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						GAGAAGCAGGGATGAGGGCAA	0.512000													20	11					0	0	1	0	0
OR3A4P	390756	broad.mit.edu	37	17	3214132	3214132	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:3214132G>A	ENST00000573491.1	-	0	359				OR3A4P_ENST00000323164.4_RNA																							GCCCCAATGTGATCAATCACT	0.517000													69	35					0	0	1	0	0
MMP25	64386	broad.mit.edu	37	16	3100083	3100083	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:3100083C>T	ENST00000336577.4	+	3	543	c.306C>T	c.(304-306)gtC>gtT	p.V102V	MMP25_ENST00000570755.1_3'UTR	NM_022468.4	NP_071913.1	Q9NPA2	MMP25_HUMAN	matrix metallopeptidase 25	102					inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(7)|prostate(1)|skin(1)	14						CGGGGCTGGTCAGGCGGCGTC	0.706000													56	93					0	0	1	0	0
THBS1	7057	broad.mit.edu	37	15	39885304	39885304	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr15:39885304C>T	ENST00000260356.5	+	18	3036	c.2871C>T	c.(2869-2871)ttC>ttT	p.F957F		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	957					activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	AGACCGATTTCCGCCGATTCC	0.493000													18	27					0	0	1	0	0
TMC1	117531	broad.mit.edu	37	9	75435858	75435858	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:75435858C>T	ENST00000297784.5	+	20	2404	c.1864C>T	c.(1864-1866)Cct>Tct	p.P622S	TMC1_ENST00000340019.3_Missense_Mutation_p.P622S|TMC1_ENST00000486417.1_3'UTR|TMC1_ENST00000396237.3_Missense_Mutation_p.P622S	NM_138691.2	NP_619636.2	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	622					sensory perception of sound	integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(21)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	36						CTGCAATGTTCCTGAGGCCAG	0.502000													40	27					0	0	1	0	0
CHMP7	91782	broad.mit.edu	37	8	23106856	23106856	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:23106856C>T	ENST00000397677.1	+	3	1081	c.433C>T	c.(433-435)Cca>Tca	p.P145S	CHMP7_ENST00000313219.7_Missense_Mutation_p.P145S	NM_152272.3	NP_689485.1	Q8WUX9	CHMP7_HUMAN	charged multivesicular body protein 7	145					cellular membrane organization|late endosome to vacuole transport	cytosol|ESCRT III complex	protein transporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11		Prostate(55;0.0513)		Colorectal(74;0.0155)|COAD - Colon adenocarcinoma(73;0.0632)		TAATAAGGTTCCAGCTGAGGA	0.562000													18	33					0	0	1	0	0
KIAA1147	57189	broad.mit.edu	37	7	141385295	141385295	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:141385295G>A	ENST00000536163.1	-	3	509	c.510C>T	c.(508-510)ttC>ttT	p.F170F	KIAA1147_ENST00000482493.1_Silent_p.F79F	NM_001080392.1	NP_001073861.1	A4D1U4	LCHN_HUMAN	KIAA1147	170										breast(3)|endometrium(4)|kidney(2)|large_intestine(1)|ovary(1)|skin(1)	12	Melanoma(164;0.0171)					GGTTCTCCAAGAAGTGCATGT	0.587000													60	106					0	0	1	0	0
CDH26	60437	broad.mit.edu	37	20	58570991	58570991	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr20:58570991C>T	ENST00000348616.4	+	12	2070	c.1770C>T	c.(1768-1770)gtC>gtT	p.V590V	CDH26_ENST00000497614.1_3'UTR|CDH26_ENST00000244047.5_Silent_p.V590V	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	590					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			AGCAAACTGTCCATGTAAGGA	0.517000													21	36					0	0	1	0	0
ATP1A3	478	broad.mit.edu	37	19	42489289	42489289	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:42489289G>A	ENST00000545399.1	-	8	966	c.813C>T	c.(811-813)ggC>ggT	p.G271G	ATP1A3_ENST00000302102.5_Silent_p.G258G|ATP1A3_ENST00000602133.1_Silent_p.G228G|ATP1A3_ENST00000543770.1_Silent_p.G269G	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	258					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						TGGCGATACGGCCCATGACAG	0.667000													15	14					0	0	1	0	0
COL4A3	1285	broad.mit.edu	37	2	228172615	228172615	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:228172615G>A	ENST00000396578.3	+	48	4604	c.4442G>A	c.(4441-4443)cGa>cAa	p.R1481Q	AC097662.2_ENST00000396588.2_RNA|AC097662.2_ENST00000433324.1_RNA|AC097662.2_ENST00000439598.2_RNA	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	1481	Collagen IV NC1.|Required for the anti-angiogenic activity of tumstatin.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGAAATCAACGAGCCCACGGA	0.473000													21	31					0	0	1	0	0
ABCB4	5244	broad.mit.edu	37	7	87035667	87035667	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:87035667C>T	ENST00000265723.4	-	26	3555	c.3444G>A	c.(3442-3444)caG>caA	p.Q1148Q	ABCB4_ENST00000545634.1_Silent_p.Q1141Q|ABCB4_ENST00000359206.3_Silent_p.Q1141Q|ABCB4_ENST00000453593.1_Silent_p.Q1094Q|ABCB4_ENST00000358400.3_Silent_p.Q1094Q	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	1148	ABC transporter 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					CAATTTCATCCTGTGATACAA	0.463000													37	81					0	0	1	0	0
NAV3	89795	broad.mit.edu	37	12	78516124	78516124	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:78516124C>T	ENST00000397909.2	+	16	4327	c.4154C>T	c.(4153-4155)tCc>tTc	p.S1385F	NAV3_ENST00000266692.7_Intron|NAV3_ENST00000228327.6_Missense_Mutation_p.S1385F|NAV3_ENST00000536525.2_Missense_Mutation_p.S1385F			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1385	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CATCATGGCTCCTTGTCTGGA	0.557000										HNSCC(70;0.22)			52	36					0	0	1	0	0
COL21A1	81578	broad.mit.edu	37	6	55925786	55925786	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:55925786C>T	ENST00000244728.5	-	26	2652	c.2255G>A	c.(2254-2256)gGa>gAa	p.G752E	COL21A1_ENST00000467045.1_5'UTR|COL21A1_ENST00000535941.1_Missense_Mutation_p.G752E|COL21A1_ENST00000370808.2_Missense_Mutation_p.G152E|COL21A1_ENST00000370819.1_Missense_Mutation_p.G749E	NM_030820.3	NP_110447.2	Q96P44	COLA1_HUMAN	collagen, type XXI, alpha 1	752	Collagen-like 5.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(1)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|prostate(2)	41	Lung NSC(77;0.0483)		LUSC - Lung squamous cell carcinoma(124;0.181)			CCCAGATTCTCCTTTTGATCC	0.507000													24	28					0	0	1	0	0
OXLD1	339229	broad.mit.edu	37	17	79632342	79632342	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:79632342G>A	ENST00000374741.3	-	2	343	c.333C>T	c.(331-333)ttC>ttT	p.F111F	OXLD1_ENST00000573786.1_5'UTR|OXLD1_ENST00000571503.1_3'UTR	NM_001039842.1	NP_001034931.1			oxidoreductase-like domain containing 1																		CACCGTCCTGGAAGTGCTGCA	0.652000													23	40					0	0	1	0	0
LRBA	987	broad.mit.edu	37	4	151271224	151271224	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:151271224G>A	ENST00000535741.1	-	48	7755	c.7282C>T	c.(7282-7284)Cga>Tga	p.R2428*	LRBA_ENST00000503716.1_5'UTR|LRBA_ENST00000510413.1_Nonsense_Mutation_p.R2428*|LRBA_ENST00000357115.3_Nonsense_Mutation_p.R2439*|LRBA_ENST00000507224.1_Nonsense_Mutation_p.R2428*			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	2439	BEACH.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					TTGAGGGCTCGGACAGCTTCT	0.418000													44	17					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117176665	117176665	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:117176665C>T	ENST00000003084.6	+	7	939	c.807C>T	c.(805-807)atC>atT	p.I269I	CFTR_ENST00000454343.1_Silent_p.I269I	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	269	ABC transmembrane type-1 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TTGAAAATATCCAATCTGTTA	0.318000									Cystic Fibrosis				8	8					0	0	1	0	0
LAMA2	3908	broad.mit.edu	37	6	129419560	129419560	+	Splice_Site	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:129419560G>A	ENST00000421865.2	+	4	688	c.639_splice	c.e4+1	p.E213_splice		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	213	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		AAAATGGAGAGGTAAGATGAG	0.398000													15	40					0	0	1	0	0
OR6K3	391114	broad.mit.edu	37	1	158687228	158687228	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:158687228C>T	ENST00000368146.1	-	1	725	c.726G>A	c.(724-726)agG>agA	p.R242R	OR6K3_ENST00000368145.1_Silent_p.R226R			Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K, member 3	242					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)	41	all_hematologic(112;0.0378)					AAGAGGGAATCCTCAATATCA	0.443000													50	26					0	0	1	0	0
CDK12	51755	broad.mit.edu	37	17	37650905	37650905	+	Missense_Mutation	SNP	G	G	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:37650905G>T	ENST00000447079.4	+	5	2410	c.2377G>T	c.(2377-2379)Gtc>Ttc	p.V793F	CDK12_ENST00000430627.2_Missense_Mutation_p.V793F	NM_015083.1|NM_016507.2	NP_055898.1|NP_057591.2	Q9NYV4	CDK12_HUMAN	cyclin-dependent kinase 12	793	Protein kinase.				mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			NS(4)|breast(3)|endometrium(5)|kidney(4)|large_intestine(11)|lung(23)|ovary(11)|prostate(4)|skin(2)|urinary_tract(3)	70						gaaggaaattgtcacagataa	0.393000			"""Mis, N, F"""		serous ovarian					TCGA Ovarian(9;0.13)			3	9					0.115264	0.115466	1	1	0
ZNF708	7562	broad.mit.edu	37	19	21476108	21476108	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:21476108G>A	ENST00000356929.3	-	4	1857	c.1660C>T	c.(1660-1662)Cat>Tat	p.H554Y		NM_021269.2	NP_067092.2	P17019	ZN708_HUMAN	zinc finger protein 708	554					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(2)|stomach(1)	32						TCTTTGGTATGAATTCTCTTA	0.318000													13	35					0	0	1	0	0
CYP2C19	1557	broad.mit.edu	37	10	96541742	96541742	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr10:96541742C>T	ENST00000371321.3	+	5	889	c.807C>T	c.(805-807)atC>atT	p.I269I	CYP2C19_ENST00000464755.1_3'UTR	NM_000769.1	NP_000760.1	P33261	CP2CJ_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 19	269					exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|electron carrier activity|enzyme binding|heme binding|oxygen binding|steroid hydroxylase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(17)|ovary(4)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	43		Colorectal(252;0.09)		all cancers(201;6.02e-07)|KIRC - Kidney renal clear cell carcinoma(50;0.0672)|Kidney(138;0.0838)	Adinazolam(DB00546)|Aminophenazone(DB01424)|Amitriptyline(DB00321)|Amoxicillin(DB01060)|Arformoterol(DB01274)|Bortezomib(DB00188)|Carisoprodol(DB00395)|Chlorzoxazone(DB00356)|Cilostazol(DB01166)|Citalopram(DB00215)|Clarithromycin(DB01211)|Clobazam(DB00349)|Desipramine(DB01151)|Desloratadine(DB00967)|Diclofenac(DB00586)|Diltiazem(DB00343)|Efavirenz(DB00625)|Esomeprazole(DB00736)|Famotidine(DB00927)|Felbamate(DB00949)|Finasteride(DB01216)|Flunitrazepam(DB01544)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Fosphenytoin(DB01320)|Guanfacine(DB01018)|Imipramine(DB00458)|Indomethacin(DB00328)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Lapatinib(DB01259)|Loratadine(DB00455)|Melatonin(DB01065)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Moclobemide(DB01171)|Modafinil(DB00745)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Nilutamide(DB00665)|Norgestrel(DB00506)|Omeprazole(DB00338)|Oxcarbazepine(DB00776)|Pantoprazole(DB00213)|Pentamidine(DB00738)|Phenobarbital(DB01174)|Phenytoin(DB00252)|Primidone(DB00794)|Progesterone(DB00396)|Proguanil(DB01131)|Promazine(DB00420)|Quinidine(DB00908)|Rabeprazole(DB01129)|Ranitidine(DB00863)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Temazepam(DB00231)|Teniposide(DB00444)|Terfenadine(DB00342)|Thalidomide(DB01041)|Thioridazine(DB00679)|Ticlopidine(DB00208)|Tolbutamide(DB01124)|Topiramate(DB00273)|Tranylcypromine(DB00752)|Troglitazone(DB00197)|Troleandomycin(DB01361)|Voriconazole(DB00582)	GCTTCCTGATCAAAATGGAGA	0.353000													30	23					0	0	1	0	0
OR9A4	130075	broad.mit.edu	37	7	141618715	141618715	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:141618715C>T	ENST00000548136.1	+	1	99	c.40C>T	c.(40-42)Ctt>Ttt	p.L14F	MGAM_ENST00000497554.1_Intron	NM_001001656.1	NP_001001656.1	Q8NGU2	OR9A4_HUMAN	olfactory receptor, family 9, subfamily A, member 4	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|large_intestine(9)|lung(7)|prostate(1)|skin(2)	22	Melanoma(164;0.0171)					ATTTTATCTCCTTGGCTTCCC	0.378000													73	121					0	0	1	0	0
PACRG	135138	broad.mit.edu	37	6	163235180	163235180	+	Splice_Site	SNP	T	T	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:163235180T>C	ENST00000337019.3	+	3	382	c.156_splice	c.e3-1	p.V53_splice	PACRG_ENST00000366889.2_Splice_Site_p.V53_splice|PACRG_ENST00000366888.2_Splice_Site_p.V53_splice|PACRG_ENST00000542669.1_3'UTR	NM_152410.2	NP_689623.2	Q96M98	PACRG_HUMAN	PARK2 co-regulated	53										endometrium(2)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20		Breast(66;2.41e-05)|Ovarian(120;0.0245)|Prostate(117;0.0273)|all_neural(5;0.0416)|Glioma(2;0.203)		OV - Ovarian serous cystadenocarcinoma(33;4.31e-19)|GBM - Glioblastoma multiforme(2;7.42e-11)|BRCA - Breast invasive adenocarcinoma(81;3.19e-05)|KIRC - Kidney renal clear cell carcinoma(3;0.205)|Kidney(3;0.242)		CCAATTAAGGTGAGAGGCCCT	0.363000													27	51					0	0	1	0	0
NLRP10	338322	broad.mit.edu	37	11	7981250	7981250	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:7981250C>T	ENST00000328600.2	-	2	2070	c.1909G>A	c.(1909-1911)Gaa>Aaa	p.E637K		NM_176821.3	NP_789791.1	Q86W26	NAL10_HUMAN	NLR family, pyrin domain containing 10	637							ATP binding	p.E637K(1)		breast(1)|endometrium(2)|kidney(2)|large_intestine(8)|liver(1)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				Epithelial(150;1.47e-07)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GTAGAAGCTTCCTTTTGTGTT	0.393000													9	31					0	0	1	0	0
QSER1	79832	broad.mit.edu	37	11	32953298	32953298	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:32953298C>T	ENST00000399302.2	+	4	442	c.107C>T	c.(106-108)tCc>tTc	p.S36F	QSER1_ENST00000527250.1_3'UTR|QSER1_ENST00000527788.1_Missense_Mutation_p.S36F	NM_001076786.1	NP_001070254.1	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	36										breast(5)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(1)|urinary_tract(1)	48	Breast(20;0.158)					GGCATGCATTCCTCAGCAGCA	0.413000													37	46					0	0	1	0	0
MAP3K10	4294	broad.mit.edu	37	19	40720929	40720929	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:40720929C>T	ENST00000253055.3	+	10	2883	c.2595C>T	c.(2593-2595)ttC>ttT	p.F865F		NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	865					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						AGGCCCTGTTCCCAGCCCGCC	0.721000													18	27					0	0	1	0	0
ZNF598	90850	broad.mit.edu	37	16	2049618	2049618	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:2049618C>T	ENST00000563630.1	-	9	2009	c.1767G>A	c.(1765-1767)cgG>cgA	p.R589R	ZNF598_ENST00000431526.1_Silent_p.R644R|ZNF598_ENST00000562103.1_Silent_p.R589R			Q86UK7	ZN598_HUMAN	zinc finger protein 598	644						intracellular	zinc ion binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|lung(7)|skin(1)|urinary_tract(1)	16						TGGGGGCACTCCGAGCAGGGG	0.721000													17	33					0	0	1	0	0
SPOCD1	90853	broad.mit.edu	37	1	32258906	32258906	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:32258906G>A	ENST00000360482.2	-	13	2787	c.2658C>T	c.(2656-2658)gtC>gtT	p.V886V	SPOCD1_ENST00000257100.3_Silent_p.V379V|SPOCD1_ENST00000533231.1_Silent_p.V886V|SPOCD1_ENST00000373648.2_3'UTR	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	886	SPOC.				transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		TGTGTCCCGAGACCAGCTGGG	0.637000													3	12					0	0	1	0	0
KLHL7	55975	broad.mit.edu	37	7	23164805	23164805	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:23164805G>A	ENST00000545771.1	+	5	603	c.390G>A	c.(388-390)caG>caA	p.Q130Q	KLHL7_ENST00000322231.7_Intron|KLHL7_ENST00000542558.1_Intron|KLHL7_ENST00000539124.1_Intron|KLHL7_ENST00000545443.1_Intron|KLHL7_ENST00000479288.1_Intron|KLHL7_ENST00000410047.1_Intron|KLHL7_ENST00000322275.5_Intron|KLHL7_ENST00000339077.4_Intron|KLHL7_ENST00000409689.1_Intron			Q8IXQ5	KLHL7_HUMAN	kelch-like family member 7	150						Golgi apparatus|nucleolus|plasma membrane				breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						AGAAATATCAGATTCCTGTTG	0.289000													14	25					0	0	1	0	0
LOC643711	643711	broad.mit.edu	37	12	98126372	98126372	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:98126372G>A	ENST00000550548.1	-	0	398					NR_077240.1																						GGCAATGGTGGTTTGTTTCTC	0.483000													3	5					0	0	1	0	0
SIRT7	51547	broad.mit.edu	37	17	79872342	79872342	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:79872342G>A	ENST00000328666.6	-	7	706	c.644C>T	c.(643-645)gCc>gTc	p.A215V		NM_016538.2	NP_057622.1	Q9NRC8	SIRT7_HUMAN	sirtuin 7	215	Deacetylase sirtuin-type.				chromatin silencing|positive regulation of transcription on exit from mitosis|protein deacetylation|rRNA transcription	cytoplasm|nucleolus organizer region	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ binding|protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	13	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)			TCTGTGGAGGGCAGTGCGCTC	0.637000													18	57					0	0	1	0	0
C2orf78	388960	broad.mit.edu	37	2	74042651	74042651	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:74042651G>A	ENST00000409561.1	+	3	1422	c.1301G>A	c.(1300-1302)gGg>gAg	p.G434E		NM_001080474.1	NP_001073943.1	A6NCI8	CB078_HUMAN	chromosome 2 open reading frame 78	434										cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(2)|prostate(2)|soft_tissue(1)|urinary_tract(1)	34						TTTGAAAATGGGATTGAGTCT	0.458000													16	26					0	0	1	0	0
C8orf4	56892	broad.mit.edu	37	8	40011367	40011367	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:40011367C>T	ENST00000315792.3	+	1	379	c.316C>T	c.(316-318)Cac>Tac	p.H106Y		NM_020130.4	NP_064515.1	Q9NR00	CH004_HUMAN	chromosome 8 open reading frame 4	106					apoptosis					breast(1)|large_intestine(1)|ovary(1)	3	Ovarian(28;0.0173)	all_cancers(7;5.34e-21)|all_epithelial(6;1.04e-14)|Lung NSC(58;9.35e-06)|all_lung(54;1.39e-05)|Hepatocellular(245;0.00745)|Breast(189;0.0334)|Colorectal(162;0.0815)|Myeloproliferative disorder(644;0.116)|Esophageal squamous(32;0.141)	LUSC - Lung squamous cell carcinoma(45;0.000149)	KIRC - Kidney renal clear cell carcinoma(67;0.0923)|Kidney(114;0.111)		CATCAAAGTTCACTGAAGAGA	0.428000													20	33					0	0	1	0	0
TECTA	7007	broad.mit.edu	37	11	121058619	121058619	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr11:121058619C>T	ENST00000392793.1	+	21	6349	c.6078C>T	c.(6076-6078)gtC>gtT	p.V2026V	TECTA_ENST00000264037.2_Silent_p.V2026V			O75443	TECTA_HUMAN	tectorin alpha	2026	ZP.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		ACGTCACCGTCTTTAAATTCA	0.438000													23	71					0	0	1	0	0
SCEL	8796	broad.mit.edu	37	13	78130755	78130755	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr13:78130755C>T	ENST00000535157.1	+	3	238	c.68C>T	c.(67-69)aCc>aTc	p.T23I	SCEL_ENST00000377246.3_Missense_Mutation_p.T23I|SCEL_ENST00000349847.3_Missense_Mutation_p.T23I	NM_001160706.1	NP_001154178.1	O95171	SCEL_HUMAN	sciellin	23					embryo development|keratinocyte differentiation	cornified envelope|cytoplasm|membrane	protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(18)|ovary(5)|prostate(1)|stomach(1)|urinary_tract(1)	40		Acute lymphoblastic leukemia(28;0.0282)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0233)		ACTCAGGGAACCACACGGAAG	0.423000													121	151					0	0	1	0	0
CNGA1	1259	broad.mit.edu	37	4	47942805	47942805	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr4:47942805G>A	ENST00000402813.3	-	9	988	c.846C>T	c.(844-846)atC>atT	p.I282I	CNGA1_ENST00000358519.4_Silent_p.I213I|CNGA1_ENST00000420489.2_Silent_p.I213I|CNGA1_ENST00000514170.1_Silent_p.I213I|CNGA1_ENST00000544810.1_Silent_p.I213I			P29973	CNGA1_HUMAN	cyclic nucleotide gated channel alpha 1	213					response to stimulus|visual perception	integral to plasma membrane	cGMP binding|ion channel activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|urinary_tract(1)	28						CAAACATATCGATTAAATAGA	0.284000													11	36					0	0	1	0	0
NDUFV2	4729	broad.mit.edu	37	18	9122581	9122581	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:9122581G>A	ENST00000400033.1	+	6	497	c.380G>A	c.(379-381)cGa>cAa	p.R127Q	RP11-143J12.2_ENST00000582375.1_RNA|RP11-21J18.1_ENST00000579126.1_RNA|RP11-143J12.2_ENST00000583081.1_RNA|NDUFV2_ENST00000318388.6_Missense_Mutation_p.R124Q|NDUFV2_ENST00000465096.1_3'UTR			P19404	NDUV2_HUMAN	NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa	124					cardiac muscle tissue development|mitochondrial electron transport, NADH to ubiquinone|nervous system development|transport	mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|electron carrier activity|metal ion binding|NAD binding|NADH dehydrogenase (ubiquinone) activity			breast(1)|lung(4)|ovary(1)|stomach(1)	7					NADH(DB00157)	ATGTATAATCGAAAGCCAGTT	0.368000													9	67					0	0	1	0	0
TXLNB	167838	broad.mit.edu	37	6	139576745	139576745	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr6:139576745G>A	ENST00000358430.3	-	7	1265	c.1033C>T	c.(1033-1035)Cag>Tag	p.Q345*		NM_153235.3	NP_694967.3	Q8N3L3	TXLNB_HUMAN	taxilin beta	345						cytoplasm				breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	37				OV - Ovarian serous cystadenocarcinoma(155;0.000185)|GBM - Glioblastoma multiforme(68;0.000235)		ACTTTCGCCTGAAGTTTCCAC	0.498000													24	26					0	0	1	0	0
MYH13	8735	broad.mit.edu	37	17	10247326	10247326	+	Missense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr17:10247326G>A	ENST00000418404.3	-	15	1848	c.1685C>T	c.(1684-1686)tCc>tTc	p.S562F	MYH13_ENST00000570743.1_Missense_Mutation_p.S562F|MYH13_ENST00000252172.4_Missense_Mutation_p.S562F			Q9UKX3	MYH13_HUMAN	myosin, heavy chain 13, skeletal muscle	562	Myosin head-like.				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(3)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(21)|lung(48)|ovary(7)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	108						GAAGTTGTTGGATTTTCCAAG	0.547000													47	17					0	0	1	0	0
NDRG1	10397	broad.mit.edu	37	8	134274298	134274298	+	Silent	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:134274298G>A	ENST00000414097.2	-	5	1185	c.318C>T	c.(316-318)ttC>ttT	p.F106F	NDRG1_ENST00000518176.1_Intron|NDRG1_ENST00000323851.7_Silent_p.F106F|NDRG1_ENST00000537882.1_Silent_p.F25F|NDRG1_ENST00000518066.1_Intron|NDRG1_ENST00000522476.1_Silent_p.F40F|NDRG1_ENST00000354944.5_Intron	NM_001135242.1	NP_001128714.1	Q92597	NDRG1_HUMAN	N-myc downstream regulated 1	106					cellular response to hypoxia|response to metal ion	cytoplasm|microtubule cytoskeleton|nucleus|plasma membrane	protein binding		NDRG1/ERG(5)	endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(4)|prostate(1)|skin(1)	17	all_epithelial(106;4.26e-24)|Lung NSC(106;7.26e-07)|all_lung(105;2.77e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0107)			ACCCTGCGGGGAAGGAGGCTG	0.582000			T	ERG	prostate								38	66					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516693	140516693	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:140516693C>T	ENST00000231134.5	+	1	1894	c.1677C>T	c.(1675-1677)ttC>ttT	p.F559F		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		559	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTCGCCCTTCGTGCTGTATC	0.716000													49	94					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43219721	43219721	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:43219721C>T	ENST00000255226.6	+	7	1670	c.854C>T	c.(853-855)gCc>gTc	p.A285V	SLC14A2_ENST00000586448.1_Missense_Mutation_p.A285V	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	285						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CTGTTACAAGCCATCCCTGTT	0.537000													60	61					0	0	1	0	0
TRBV7-6	28592	broad.mit.edu	37	7	142139373	142139373	+	RNA	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:142139373G>A	ENST00000390374.3	-	0	296																											TCTCTGCAGAGAACCGATCAT	0.562000													52	72					0	0	1	0	0
SCAF1	58506	broad.mit.edu	37	19	50148305	50148305	+	Nonsense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:50148305C>T	ENST00000360565.3	+	2	146	c.22C>T	c.(22-24)Cga>Tga	p.R8*		NM_021228.2	NP_067051.2	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	8					mRNA processing|RNA splicing	nucleus	RNA binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	20		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		AGATGAGTCTCGAGGGAAGAC	0.592000													5	11					0	0	1	0	0
GRPEL2	134266	broad.mit.edu	37	5	148730806	148730806	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:148730806C>T	ENST00000329271.3	+	4	749	c.639C>T	c.(637-639)gcC>gcT	p.A213A	GRPEL2_ENST00000507562.1_3'UTR|RP11-394O4.4_ENST00000521295.1_RNA|GRPEL2_ENST00000416916.2_3'UTR	NM_152407.3	NP_689620.2	Q8TAA5	GRPE2_HUMAN	GrpE-like 2, mitochondrial (E. coli)	213					protein folding	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity	p.L212fs*>8(1)		breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTAGGCTTGCCCGAGTGGAAG	0.512000													18	49					0	0	1	0	0
SLC38A4	55089	broad.mit.edu	37	12	47173646	47173646	+	Splice_Site	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr12:47173646C>T	ENST00000447411.1	-	8	782		c.e8-1		SLC38A4_ENST00000266579.4_Splice_Site	NM_001143824.1	NP_001137296.1	Q969I6	S38A4_HUMAN	solute carrier family 38, member 4						cellular nitrogen compound metabolic process|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	21	Lung SC(27;0.192)|Renal(347;0.236)					GTACCATTCTCTAGAAGTGAG	0.358000													11	21					0	0	1	0	0
NSD1	64324	broad.mit.edu	37	5	176562160	176562160	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr5:176562160C>T	ENST00000439151.2	+	2	101	c.56C>T	c.(55-57)cCa>cTa	p.P19L	NSD1_ENST00000347982.4_5'UTR|NSD1_ENST00000354179.4_5'UTR|NSD1_ENST00000361032.4_Missense_Mutation_p.P19L|NSD1_ENST00000511258.1_5'UTR	NM_022455.4	NP_071900.2	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	19					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(18)|lung(24)|ovary(2)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(3)	96	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TTTTCCAATCCAGTGAATTTA	0.458000			T	NUP98	AML		Sotos Syndrome		Weaver syndrome;Sotos syndrome;Beckwith-Wiedemann syndrome	HNSCC(47;0.14)			58	59					0	0	1	0	0
GCDH	2639	broad.mit.edu	37	19	13008525	13008525	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr19:13008525C>T	ENST00000222214.5	+	11	1302	c.1091C>T	c.(1090-1092)cCc>cTc	p.P364L	GCDH_ENST00000457854.1_Missense_Mutation_p.P364L|GCDH_ENST00000422947.2_Missense_Mutation_p.P320L|GCDH_ENST00000591470.1_Missense_Mutation_p.P364L			Q92947	GCDH_HUMAN	glutaryl-CoA dehydrogenase	364					lysine catabolic process	mitochondrial matrix	flavin adenine dinucleotide binding|glutaryl-CoA dehydrogenase activity|protein binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(8)	19						AGGGCTGCCCCCGAGATGGTT	0.607000													83	179					0	0	1	0	0
TMED8	283578	broad.mit.edu	37	14	77809810	77809810	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr14:77809810C>T	ENST00000216468.7	-	5	526	c.471G>A	c.(469-471)atG>atA	p.M157I		NM_213601.1	NP_998766.1	Q6PL24	TMED8_HUMAN	transmembrane emp24 protein transport domain containing 8	157					transport	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)	15			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		ATGGAGGAGCCATCAGAGGTG	0.527000													7	5					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39581304	39581304	+	Nonsense_Mutation	SNP	G	G	A			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:39581304G>A	ENST00000265707.5	+	19	2100	c.2055G>A	c.(2053-2055)tgG>tgA	p.W685*	ADAM18_ENST00000523755.1_3'UTR|ADAM18_ENST00000541111.1_Nonsense_Mutation_p.W99*|ADAM18_ENST00000379866.1_Nonsense_Mutation_p.W661*	NM_014237.2	NP_055052.1	Q9Y3Q7	ADA18_HUMAN	ADAM metallopeptidase domain 18	685					cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			ATACACACTGGAACAACTGGT	0.294000													23	38					0	0	1	0	0
DCC	1630	broad.mit.edu	37	18	50866095	50866095	+	Missense_Mutation	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr18:50866095C>T	ENST00000442544.2	+	15	2793	c.2177C>T	c.(2176-2178)cCt>cTt	p.P726L	DCC_ENST00000581580.1_Missense_Mutation_p.P381L|DCC_ENST00000412726.1_Missense_Mutation_p.P574L	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	726	Fibronectin type-III 4.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TCTCAAGTTCCTGATCAACCA	0.428000													37	65					0	0	1	0	0
PLOD1	5351	broad.mit.edu	37	1	12018692	12018692	+	Silent	SNP	C	C	T			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr1:12018692C>T	ENST00000196061.4	+	9	990	c.963C>T	c.(961-963)ttC>ttT	p.F321F	PLOD1_ENST00000376369.3_Silent_p.F368F	NM_000302.3	NP_000293.2	Q02809	PLOD1_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	321					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	TGCGACTTTTCATCCACAACC	0.587000													10	46					0	0	1	0	0
GAL3ST2	64090	broad.mit.edu	37	2	242738494	242738496	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr2:242738494_242738496delTCC	ENST00000192314.6	+	2	175_177	c.44_46delTCC	c.(43-48)atc>a	p.IL15del		NM_022134.2	NP_071417.2	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	15					biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity	p.L16I(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|skin(1)	14		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		TTCCGGGTCATCCTCCTCCTCCT	0.631													7	102	---	---	---	---					
ATP6V0A4	50617	broad.mit.edu	37	7	138453566	138453566	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:138453566delT	ENST00000310018.2	-	5	532	c.250delA	c.(250-252)gcfs	p.S84fs	ATP6V0A4_ENST00000393054.1_Frame_Shift_Del_p.S84fs|ATP6V0A4_ENST00000353492.4_Frame_Shift_Del_p.S84fs|ATP6V0A4_ENST00000483139.1_5'UTR	NM_020632.2|NM_130840.2	NP_065683.2|NP_570855.2	Q9HBG4	VPP4_HUMAN	ATPase, H+ transporting, lysosomal V0 subunit a4	84					cellular iron ion homeostasis|excretion|insulin receptor signaling pathway|ossification|regulation of pH|sensory perception of sound|transferrin transport	apical plasma membrane|brush border membrane|endosome membrane|integral to membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	ATPase binding|hydrogen ion transmembrane transporter activity			NS(1)|endometrium(3)|kidney(2)|large_intestine(10)|lung(15)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	36						GTCAGTGGGCTTTTCTCGAGC	0.488													25	30	---	---	---	---					
ZNF777	27153	broad.mit.edu	37	7	149129966	149129968	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr7:149129966_149129968delTCC	ENST00000247930.4	-	6	1718_1720	c.1395_1397delGGA	c.(1393-1398)gat>ga	p.ED465del		NM_015694.2	NP_056509.2	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	465	Glu-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(5)|lung(17)|ovary(1)|skin(2)|urinary_tract(1)	26	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			CGGCAGctcatcctcctcctcct	0.606													5	9	---	---	---	---					
CHD7	55636	broad.mit.edu	37	8	61764713	61764713	+	Frame_Shift_Del	DEL	T	T	-			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr8:61764713delT	ENST00000423902.2	+	29	6280	c.5801delT	c.(5800-5802)cafs	p.L1934fs	CHD7_ENST00000524602.1_Intron	NM_017780.3	NP_060250.2	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1934					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(8)|cervix(2)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(16)|lung(49)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|urinary_tract(3)	123		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			CAAGAGGCCCTAATGAAGACT	0.527													38	57	---	---	---	---					
SETX	23064	broad.mit.edu	37	9	135140315	135140320	+	In_Frame_Del	DEL	TAATAA	TAATAA	-			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr9:135140315_135140320delTAATAA	ENST00000372169.2	-	27	7609_7614	c.7427_7432delTTATTA	c.(7426-7434)aag>a	p.IIK2476del	SETX_ENST00000477049.1_5'UTR|SETX_ENST00000224140.5_In_Frame_Del_p.IIK2447del|SETX_ENST00000393220.1_In_Frame_Del_p.IIK2414del			Q7Z333	SETX_HUMAN	senataxin	2447					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			breast(7)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(1)|lung(36)|ovary(2)|prostate(2)|skin(1)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	97		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		TCACAGGTCTTAATAATGGCACCACG	0.447													24	21	---	---	---	---					
ZNF768	79724	broad.mit.edu	37	16	30537042	30537062	+	In_Frame_Del	DEL	GGGCTCCGGGGTTCATACCCG	GGGCTCCGGGGTTCATACCCG	-			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr16:30537042_30537062delGGGCTCCGGGGTTCATACCCG	ENST00000380412.5	-	2	574_594	c.399_419delCGGGTATGAACCCCGGAGCCC	c.(397-420)cct>cc	p.PGYEPRSP133del	ZNF768_ENST00000562803.1_In_Frame_Del_p.PGYEPRSP102del	NM_024671.3	NP_078947.3	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	133	Pro-rich.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						TTCATAGCCAGGGCTCCGGGGTTCATACCCGGGGCTCCGAG	0.511													28	55	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11085863	11085864	+	RNA	INS	-	-	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chr21:11085863_11085864insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		catcaccaccaccaccatcacc	0.579													2	4	---	---	---	---					
FLNA	2316	broad.mit.edu	37	X	153590823	153590824	+	Frame_Shift_Ins	INS	-	-	C			TCGA-D3-A5GO-06A-12D-A27K-08	TCGA-D3-A5GO-10A-01D-A27N-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	0c87561d-7f5c-435e-85b4-e514f68fdbda	af3bfb9a-a75c-4fff-8d38-0bcd1c174dc1	g.chrX:153590823_153590824insC	ENST00000422373.1	-	17	2775_2776	c.2527_2528insG	c.(2527-2529)tggfs	p.W843fs	FLNA_ENST00000369850.3_Frame_Shift_Ins_p.W843fs|FLNA_ENST00000360319.4_Frame_Shift_Ins_p.W843fs|FLNA_ENST00000344736.4_Frame_Shift_Ins_p.W843fs	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	843					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GTAGCTGCCAGCCCCCCGGGGC	0.599													76	19	---	---	---	---					
