Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ACMSD	130013	broad.mit.edu	37	2	135616917	135616917	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr2:135616917G>A	ENST00000392928.1	+	4	361	c.65G>A	c.(64-66)tGg>tAg	p.W22*	ACMSD_ENST00000356140.5_Missense_Mutation_p.M63I|AC016725.4_ENST00000392929.2_RNA|ACMSD_ENST00000283054.4_Nonsense_Mutation_p.W22*			Q8TDX5	ACMSD_HUMAN	aminocarboxymuconate semialdehyde decarboxylase	0					quinolinate metabolic process|tryptophan catabolic process	cytosol	aminocarboxymuconate-semialdehyde decarboxylase activity|metal ion binding			endometrium(3)|large_intestine(4)|lung(6)|skin(1)	14				BRCA - Breast invasive adenocarcinoma(221;0.115)		TTAGAGAAATGGACCAAAAAG	0.423000													7	44					0	0	0.335167	0	0
ACVR1	90	broad.mit.edu	37	2	158634711	158634711	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr2:158634711G>A	ENST00000263640.3	-	5	904	c.475C>T	c.(475-477)Ccc>Tcc	p.P159S	ACVR1_ENST00000487456.1_5'UTR|ACVR1_ENST00000409283.2_Missense_Mutation_p.P159S|ACVR1_ENST00000434821.1_Missense_Mutation_p.P159S|ACVR1_ENST00000410057.2_Missense_Mutation_p.P159S	NM_001105.4	NP_001096.1	Q04771	ACVR1_HUMAN	activin A receptor, type I	159					BMP signaling pathway|G1/S transition of mitotic cell cycle|negative regulation of activin receptor signaling pathway|negative regulation of apoptosis|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	activin receptor complex	activin binding|ATP binding|follistatin binding|metal ion binding|protein homodimerization activity|SMAD binding|transforming growth factor beta binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|ovary(2)|skin(2)	19				BRCA - Breast invasive adenocarcinoma(221;0.104)	Adenosine triphosphate(DB00171)	ACGTCTCGGGGATTGAGGCGT	0.493000													20	29					0	0	0.654019	0	0
TMEM230	29058	broad.mit.edu	37	20	5086941	5086941	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr20:5086941G>A	ENST00000379286.2	-	4	535	c.115C>T	c.(115-117)Cct>Tct	p.P39S	TMEM230_ENST00000379277.2_Missense_Mutation_p.P39S|TMEM230_ENST00000379283.2_Missense_Mutation_p.P39S|TMEM230_ENST00000492419.1_5'UTR|TMEM230_ENST00000342308.5_Missense_Mutation_p.P102S|TMEM230_ENST00000202834.7_Missense_Mutation_p.P39S|TMEM230_ENST00000379279.2_Missense_Mutation_p.P39S	NM_001009924.1	NP_001009924.1	Q96A57	CT030_HUMAN	transmembrane protein 230	39						integral to membrane											GGGATCTTAGGAGGGGTTTTC	0.388000													18	15					0	0	0.575678	0	0
LAMA2	3908	broad.mit.edu	37	6	129634041	129634041	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr6:129634041C>T	ENST00000421865.2	+	23	3259	c.3210C>T	c.(3208-3210)ttC>ttT	p.F1070F		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	1070	Laminin EGF-like 12.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CCTTGGATTTCCAATGCAATG	0.403000													18	10					0	0	0.557998	0	0
MYEOV2	150678	broad.mit.edu	37	2	241075674	241075674	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr2:241075674G>A	ENST00000307266.3	-	1	90	c.91C>T	c.(91-93)Ccc>Tcc	p.P31S	MYEOV2_ENST00000607357.1_Missense_Mutation_p.P10S	NM_138336.1	NP_612209.1	Q8WXC6	MYOV2_HUMAN	myeloma overexpressed 2	10										breast(1)|lung(5)|pancreas(1)	7		all_epithelial(40;1.56e-11)|Breast(86;0.0002)|Renal(207;0.00571)|Ovarian(221;0.104)|all_hematologic(139;0.182)|all_lung(227;0.229)|Melanoma(123;0.238)		Epithelial(121;3.81e-30)|all cancers(36;1.1e-27)|OV - Ovarian serous cystadenocarcinoma(60;2.74e-14)|Kidney(56;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;8.54e-06)|Lung(119;0.00361)|LUSC - Lung squamous cell carcinoma(224;0.0153)|Colorectal(34;0.0202)|COAD - Colon adenocarcinoma(134;0.143)		GCGCCCTCGGGGAACATCTCG	0.736000													4	8					0	0	0.150653	0	0
POLR2D	5433	broad.mit.edu	37	2	128608250	128608250	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr2:128608250G>A	ENST00000272645.4	-	3	320	c.264C>T	c.(262-264)ctC>ctT	p.L88L	POLR2D_ENST00000409955.1_Intron|POLR2D_ENST00000409698.1_Silent_p.L50L|POLR2D_ENST00000487079.1_Intron	NM_004805.3	NP_004796.1	O15514	RPB4_HUMAN	polymerase (RNA) II (DNA directed) polypeptide D	88					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA-directed RNA polymerase activity|nucleotide binding			large_intestine(1)|lung(4)|urinary_tract(1)	6	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0675)		GCTTTTTCTGGAGtagcaagc	0.363000													27	31					0	0	0.681144	0	0
PSG6	5675	broad.mit.edu	37	19	43414732	43414732	+	Splice_Site	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr19:43414732G>A	ENST00000187910.2	-	3	771	c.706_splice	c.e3+1	p.P236_splice	PSG6_ENST00000402603.4_Splice_Site_p.H236_splice|PSG6_ENST00000292125.2_Splice_Site_p.P236_splice	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				AGATACTCACGGAGGAGATTC	0.527000													103	84					0	0	0.870114	0	0
COL4A6	1288	broad.mit.edu	37	X	107431170	107431170	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chrX:107431170G>A	ENST00000334504.7	-	22	1908	c.1675C>T	c.(1675-1677)Cgg>Tgg	p.R559W	COL4A6_ENST00000545689.1_Missense_Mutation_p.R559W|COL4A6_ENST00000394872.2_Missense_Mutation_p.R560W|COL4A6_ENST00000538570.1_Missense_Mutation_p.R559W|COL4A6_ENST00000372216.4_Missense_Mutation_p.R560W	NM_033641.2	NP_378667.1	Q14031	CO4A6_HUMAN	collagen, type IV, alpha 6	560	Triple-helical region.				cell adhesion|extracellular matrix organization	collagen type IV	extracellular matrix structural constituent|protein binding	p.R559W(1)		breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(20)|lung(41)|ovary(7)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	92						GAATCACCCCGATCTCCTGGC	0.537000									Alport syndrome with Diffuse Leiomyomatosis				99	12					0	0	0.870114	0	0
INPPL1	3636	broad.mit.edu	37	11	71939791	71939791	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr11:71939791C>T	ENST00000298229.2	+	4	622	c.418C>T	c.(418-420)Ccg>Tcg	p.P140S	INPPL1_ENST00000538751.1_5'UTR|INPPL1_ENST00000541756.1_5'UTR	NM_001567.3	NP_001558.3	O15357	SHIP2_HUMAN	inositol polyphosphate phosphatase-like 1	140					actin filament organization|cell adhesion|endocytosis	actin cortical patch|cytosol	actin binding|SH2 domain binding|SH3 domain binding			breast(2)|endometrium(9)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						TGAGAAGCCCCCGCTGCCCCC	0.652000													19	8					0	0	0.592651	0	0
PRKG1	5592	broad.mit.edu	37	10	54053573	54053573	+	Silent	SNP	C	C	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr10:54053573C>A	ENST00000373980.4	+	18	2391	c.1974C>A	c.(1972-1974)ccC>ccA	p.P658P	PRKG1_ENST00000373985.1_Silent_p.P631P|PRKG1-AS1_ENST00000426785.2_RNA|PRKG1-AS1_ENST00000452247.2_RNA|PRKG1_ENST00000401604.2_Silent_p.P643P|PRKG1_ENST00000373975.2_Silent_p.P361P	NM_006258.3	NP_006249.1	Q13976	KGP1_HUMAN	protein kinase, cGMP-dependent, type I	643	AGC-kinase C-terminal.				actin cytoskeleton organization|platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	53		all_cancers(4;2.13e-08)|all_epithelial(4;2.44e-08)|all_lung(4;0.000173)		all cancers(4;1.18e-05)|GBM - Glioblastoma multiforme(4;0.000359)|Epithelial(53;0.00532)|Lung(62;0.0606)		TTGCATCACCCACAGACACAA	0.368000													11	25					9.31168e-06	9.60729e-06	0.435327	1	0
TRANK1	9881	broad.mit.edu	37	3	36874965	36874965	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr3:36874965C>T	ENST00000301807.6	-	21	6224	c.4327G>A	c.(4327-4329)Ggg>Agg	p.G1443R	TRANK1_ENST00000428977.2_Missense_Mutation_p.G1443R|TRANK1_ENST00000429976.2_Missense_Mutation_p.G1993R	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	1993					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AGGATTACCCCTTGCAGGAAG	0.507000													3	16					0	0	0.115264	0	0
ARPP21	10777	broad.mit.edu	37	3	35758848	35758848	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr3:35758848C>T	ENST00000187397.4	+	13	1450	c.995_splice	c.e13+1	p.R332_splice	ARPP21_ENST00000444190.1_Intron|ARPP21_ENST00000417925.1_Splice_Site_p.R298_splice|ARPP21_ENST00000337271.5_Intron|ARPP21_ENST00000458225.1_Splice_Site_p.R298_splice	NM_016300.4	NP_057384.2	Q9UBL0	ARP21_HUMAN	cAMP-regulated phosphoprotein, 21kDa	332						cytoplasm	nucleic acid binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(31)|ovary(3)|prostate(4)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	61						ACAGCTCTTTCGGTTGGTATG	0.303000													14	22					0	0	0.457914	0	0
CD163L1	283316	broad.mit.edu	37	12	7559289	7559289	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr12:7559289A>C	ENST00000313599.3	-	5	983	c.926T>G	c.(925-927)cTt>cGt	p.L309R	CD163L1_ENST00000416109.2_Missense_Mutation_p.L319R|CD163L1_ENST00000396630.1_Missense_Mutation_p.L309R			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	309	SRCR 3.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						AGCGAAGTGAAGTGCGGTTCC	0.507000													44	28					0	0	0.870114	0	0
STOML3	161003	broad.mit.edu	37	13	39542604	39542604	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr13:39542604C>T	ENST00000379631.4	-	6	928	c.584G>A	c.(583-585)cGg>cAg	p.R195Q	STOML3_ENST00000423210.1_Missense_Mutation_p.R186Q	NM_145286.2	NP_660329.1	Q8TAV4	STML3_HUMAN	stomatin (EPB72)-like 3	195						integral to membrane|plasma membrane				breast(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	11		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		CACGGGAATCCGAACATCTTT	0.522000													28	39					0	0	0.729181	0	0
HTT	3064	broad.mit.edu	37	4	3210518	3210518	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr4:3210518C>T	ENST00000355072.5	+	46	6316	c.6171C>T	c.(6169-6171)tcC>tcT	p.S2057S		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	2057					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GGCTCTATTCCCTGCTGGACA	0.433000													9	11					0	0	0.335167	0	0
INSL4	3641	broad.mit.edu	37	9	5231701	5231701	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr9:5231701G>A	ENST00000239316.4	+	1	283	c.178G>A	c.(178-180)Gaa>Aaa	p.E60K		NM_002195.1	NP_002186.1	Q14641	INSL4_HUMAN	insulin-like 4 (placenta)	60					cell proliferation|cell-cell signaling|female pregnancy|multicellular organismal development|signal transduction	extracellular space|soluble fraction	hormone activity|insulin-like growth factor receptor binding			endometrium(2)|lung(2)|skin(1)|urinary_tract(1)	6	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.14)		GTGGCTGCTGGAATCTGGACG	0.522000													9	3					0	0	0.361761	0	0
SPEF2	79925	broad.mit.edu	37	5	35793359	35793359	+	Missense_Mutation	SNP	G	G	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr5:35793359G>T	ENST00000440995.2	+	32	4638	c.4638G>T	c.(4636-4638)gaG>gaT	p.E1546D	SPEF2_ENST00000356031.3_Missense_Mutation_p.E1551D|CTD-2113L7.1_ENST00000510433.1_RNA|SPEF2_ENST00000303129.4_Missense_Mutation_p.E348D			Q9C093	SPEF2_HUMAN	sperm flagellar 2	1551					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TTCCCTTGGAGGAGGAGCTCC	0.478000													16	65					1.15088e-07	1.20011e-07	0.500413	1	0
MYH6	4624	broad.mit.edu	37	14	23862255	23862255	+	Silent	SNP	G	G	A	rs140314752		TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr14:23862255G>A	ENST00000405093.3	-	24	3187	c.3117C>T	c.(3115-3117)tcC>tcT	p.S1039S	MYH6_ENST00000356287.3_Silent_p.S1039S	NM_002471.3	NP_002462.2	P13533	MYH6_HUMAN	myosin, heavy chain 6, cardiac muscle, alpha	1039					adult heart development|atrial cardiac muscle tissue morphogenesis|cardiac muscle fiber development|in utero embryonic development|muscle filament sliding|regulation of ATPase activity|regulation of blood pressure|regulation of heart rate|regulation of the force of heart contraction|sarcomere organization|striated muscle contraction|ventricular cardiac muscle tissue morphogenesis|visceral muscle development	cytosol|focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|protein kinase binding|structural constituent of muscle			breast(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(16)|liver(1)|lung(60)|ovary(2)|pancreas(3)|prostate(6)|skin(6)|stomach(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	119	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00764)|READ - Rectum adenocarcinoma(4;0.0289)|Colorectal(4;0.0441)		CTTGCTCTAGGGATCCCTCCA	0.498000													20	40					0	0	0.608945	0	0
RAD51D	5892	broad.mit.edu	37	17	33428002	33428002	+	Silent	SNP	C	C	T	rs147669627		TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr17:33428002C>T	ENST00000345365.6	-	10	1212	c.957G>A	c.(955-957)caG>caA	p.Q319Q	RAD51D_ENST00000590016.1_Silent_p.Q339Q|RAD51D_ENST00000460118.2_Silent_p.Q200Q|RAD51D_ENST00000335858.7_Silent_p.Q207Q|RAD51L3-RFFL_ENST00000593039.1_Intron|RAD51D_ENST00000360276.3_Silent_p.Q274Q|RAD51D_ENST00000394589.4_Silent_p.Q319Q|RAD51D_ENST00000590380.1_5'UTR	NM_002878.3	NP_002869.3	O75771	RA51D_HUMAN	RAD51 paralog D	319					DNA repair|reciprocal meiotic recombination	nucleus	ATP binding|DNA binding|DNA-dependent ATPase activity|protein binding	p.Q319H(1)|p.Q207H(1)|p.Q339H(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|liver(1)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	13						ATGTGGCACTCTGCTCTGAGG	0.527000								Direct reversal of damage					47	39					0	0	0.870114	0	0
LNX2	222484	broad.mit.edu	37	13	28130496	28130496	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr13:28130496G>A	ENST00000316334.3	-	7	1552	c.1423C>T	c.(1423-1425)Cca>Tca	p.P475S		NM_153371.3	NP_699202.1	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	475	PDZ 3.						zinc ion binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	31		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		GATTCATGTGGTTCCTTCTTT	0.438000													10	13					0	0	0.335167	0	0
HTT	3064	broad.mit.edu	37	4	3210517	3210517	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr4:3210517C>T	ENST00000355072.5	+	46	6315	c.6170C>T	c.(6169-6171)tCc>tTc	p.S2057F		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	2057					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		AGGCTCTATTCCCTGCTGGAC	0.428000													9	11					0	0	0.335167	0	0
FIG4	9896	broad.mit.edu	37	6	110088053	110088053	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr6:110088053G>A	ENST00000230124.3	+	15	1829	c.1705G>A	c.(1705-1707)Gac>Aac	p.D569N	FIG4_ENST00000441478.2_Missense_Mutation_p.D292N	NM_014845.5	NP_055660.1	Q92562	FIG4_HUMAN	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	569					cell death	endosome membrane	protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)	32		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		GCACTCCAAAGACATCATGCA	0.388000													14	51					0	0	0.479597	0	0
KIAA2018	205717	broad.mit.edu	37	3	113373885	113373885	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr3:113373885T>C	ENST00000316407.4	-	7	7054	c.6644A>G	c.(6643-6645)aAt>aGt	p.N2215S	KIAA2018_ENST00000491165.1_Intron|KIAA2018_ENST00000478658.1_Missense_Mutation_p.N2215S	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	2215					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						GGCAGAGGAATTTGCTATTGT	0.408000													7	30					0	0	0.278610	0	0
ANK3	288	broad.mit.edu	37	10	61831219	61831219	+	Silent	SNP	T	T	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr10:61831219T>C	ENST00000280772.1	-	37	9611	c.9420A>G	c.(9418-9420)caA>caG	p.Q3140Q	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3140					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GAGAAGGAGGTTGCTTTTGCT	0.428000													25	39					0	0	0.654019	0	0
UBE3C	9690	broad.mit.edu	37	7	157060408	157060408	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr7:157060408C>T	ENST00000348165.5	+	23	3571	c.3211C>T	c.(3211-3213)Ctc>Ttc	p.L1071F		NM_014671.2	NP_055486.2	Q15386	UBE3C_HUMAN	ubiquitin protein ligase E3C	1071	HECT.				protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			central_nervous_system(2)|endometrium(3)|kidney(16)|large_intestine(13)|lung(25)|ovary(2)|prostate(1)|urinary_tract(1)	63		all_hematologic(28;0.0185)|all_epithelial(9;0.0664)	OV - Ovarian serous cystadenocarcinoma(82;0.00448)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)		AAGTAAACTTCTCTATGCGAT	0.567000													79	65					0	0	0.870114	0	0
NWD1	284434	broad.mit.edu	37	19	16908608	16908608	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr19:16908608G>A	ENST00000524140.2	+	16	3788	c.3370G>A	c.(3370-3372)Gat>Aat	p.D1124N	NWD1_ENST00000523826.1_Missense_Mutation_p.D918N|NWD1_ENST00000379808.3_Missense_Mutation_p.D1124N|NWD1_ENST00000339803.6_Missense_Mutation_p.D989N|NWD1_ENST00000552788.1_Missense_Mutation_p.D1124N|NWD1_ENST00000549814.1_Missense_Mutation_p.D1124N	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1124							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CATGGCCATGGATCTGGAACA	0.537000													88	81					0	0	0.870114	0	0
NT5C1B	93034	broad.mit.edu	37	2	18766202	18766202	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr2:18766202G>A	ENST00000304081.4	-	4	401	c.301C>T	c.(301-303)Cca>Tca	p.P101S	NT5C1B_ENST00000600945.1_Missense_Mutation_p.P161S|NT5C1B-RDH14_ENST00000532967.1_Missense_Mutation_p.P161S|NT5C1B_ENST00000359846.2_Missense_Mutation_p.P161S	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				TGCAGGCTTGGGGAGGTGGAT	0.706000													4	6					0	0	0.184627	0	0
RAB2B	84932	broad.mit.edu	37	14	21931881	21931881	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr14:21931881G>A	ENST00000397762.1	-	6	508	c.408C>T	c.(406-408)gcC>gcT	p.A136A	RAB2B_ENST00000461909.1_5'UTR	NM_001163380.1|NM_032846.3	NP_001156852.1|NP_116235.2	Q8WUD1	RAB2B_HUMAN	RAB2B, member RAS oncogene family	136					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane|plasma membrane	GTP binding			NS(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)	6	all_cancers(95;0.000858)		Epithelial(56;1.53e-06)|all cancers(55;1.44e-05)	GBM - Glioblastoma multiforme(265;0.00391)		CCCTAGCAAAGGCCTCTCCTT	0.413000													22	51					0	0	0.667858	0	0
CDH18	1016	broad.mit.edu	37	5	19473754	19473754	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr5:19473754G>A	ENST00000507958.1	-	15	2944	c.1954C>T	c.(1954-1956)Cgg>Tgg	p.R652W	CDH18_ENST00000510297.1_5'UTR|CDH18_ENST00000382275.1_Missense_Mutation_p.R652W|CDH18_ENST00000502796.1_3'UTR|CDH18_ENST00000274170.4_Missense_Mutation_p.R652W|CDH18_ENST00000506372.1_3'UTR			Q13634	CAD18_HUMAN	cadherin 18, type 2	652					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					ACGTTCTCCCGTACATCCTCT	0.478000													40	145					0	0	0.840704	0	0
CUX2	23316	broad.mit.edu	37	12	111776230	111776230	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr12:111776230C>T	ENST00000261726.6	+	20	3491	c.3337C>T	c.(3337-3339)Ccc>Tcc	p.P1113S		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1113						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						GCTCAATGACCCCCATAACGT	0.587000													25	25					0	0	0.693898	0	0
ACAN	176	broad.mit.edu	37	15	89401973	89401973	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr15:89401973G>A	ENST00000439576.2	+	12	6531	c.6157G>A	c.(6157-6159)Gaa>Aaa	p.E2053K	ACAN_ENST00000559004.1_Missense_Mutation_p.E2053K|ACAN_ENST00000352105.7_Missense_Mutation_p.E2053K|ACAN_ENST00000561243.1_Missense_Mutation_p.E2053K	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	2053					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TATTTCTCAGGAACTAGGCCA	0.517000													16	14					0	0	0.500413	0	0
MAGEH1	28986	broad.mit.edu	37	X	55479006	55479006	+	Missense_Mutation	SNP	G	G	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chrX:55479006G>C	ENST00000342972.1	+	1	469	c.199G>C	c.(199-201)Gaa>Caa	p.E67Q		NM_014061.3	NP_054780.2	Q9H213	MAGH1_HUMAN	melanoma antigen family H, 1	67	MAGE.				apoptosis					central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|ovary(1)|skin(2)	15						CACCCCTGAAGAAGCCTCGAG	0.587000													3	31					0	0	0.115264	0	0
STX17	55014	broad.mit.edu	37	9	102677597	102677597	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr9:102677597C>T	ENST00000259400.6	+	2	212	c.76C>T	c.(76-78)Cca>Tca	p.P26S	STX17_ENST00000534052.1_Missense_Mutation_p.P26S|STX17_ENST00000525640.1_Missense_Mutation_p.P26S|RP11-60I3.4_ENST00000524512.1_RNA	NM_017919.2	NP_060389.2	P56962	STX17_HUMAN	syntaxin 17	26					intracellular protein transport|vesicle-mediated transport	endoplasmic reticulum|integral to membrane|nucleolus	SNAP receptor activity			endometrium(2)|large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)	7		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				GATAGTAATCCCAACAGACCT	0.343000													20	5					0	0	0.557998	0	0
TIMELESS	8914	broad.mit.edu	37	12	56814624	56814624	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr12:56814624G>A	ENST00000229201.4	-	25	3233	c.3079C>T	c.(3079-3081)Cga>Tga	p.R1027*	TIMELESS_ENST00000554616.1_Nonsense_Mutation_p.R525*|TIMELESS_ENST00000553532.1_Nonsense_Mutation_p.R1028*	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	1028					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						TCAGCTGCTCGGATCAGGCAG	0.522000													14	44					0	0	0.520397	0	0
FIG4	9896	broad.mit.edu	37	6	110088051	110088051	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr6:110088051A>G	ENST00000230124.3	+	15	1827	c.1703A>G	c.(1702-1704)aAa>aGa	p.K568R	FIG4_ENST00000441478.2_Missense_Mutation_p.K291R	NM_014845.5	NP_055660.1	Q92562	FIG4_HUMAN	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	568					cell death	endosome membrane	protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)	32		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		CAGCACTCCAAAGACATCATG	0.393000													14	53					0	0	0.457914	0	0
DNAH1	25981	broad.mit.edu	37	3	52422547	52422547	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr3:52422547C>T	ENST00000420323.2	+	58	9546	c.9285C>T	c.(9283-9285)taC>taT	p.Y3095Y		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	3095	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AGGCTAAGTACCGGGAATGCA	0.607000													6	3					0	0	0.217242	0	0
MYO3B	140469	broad.mit.edu	37	2	171055894	171055894	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr2:171055894C>T	ENST00000334231.6	+	2	206	c.206C>T	c.(205-207)cCa>cTa	p.P69L	MYO3B_ENST00000409044.3_Missense_Mutation_p.P60L|MYO3B_ENST00000408978.4_Missense_Mutation_p.P60L|MYO3B_ENST00000602629.1_3'UTR			Q8WXR4	MYO3B_HUMAN	myosin IIIB	60	Protein kinase.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						ATTCTGGATCCAGTCAGTGTA	0.368000													7	4					0	0	0.248553	0	0
LPPR2	64748	broad.mit.edu	37	19	11470537	11470537	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr19:11470537C>T	ENST00000251473.5	+	5	672	c.296C>T	c.(295-297)cCa>cTa	p.P99L	DKFZP761J1410_ENST00000591608.1_Missense_Mutation_p.P74L	NM_001170635.1|NM_022737.2	NP_001164106.1|NP_073574.2																					TTCCCTGCACCACCTTCAGCC	0.647000													11	21					0	0	0.387290	0	0
GPR116	221395	broad.mit.edu	37	6	46849211	46849211	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr6:46849211G>A	ENST00000283296.7	-	8	1083	c.795C>T	c.(793-795)tcC>tcT	p.S265S	GPR116_ENST00000456426.2_Silent_p.S265S|GPR116_ENST00000362015.4_Silent_p.S265S|GPR116_ENST00000265417.7_Silent_p.S265S	NM_001098518.1	NP_001091988.1	Q8IZF2	GP116_HUMAN	G protein-coupled receptor 116	265	SEA.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(21)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	59			Lung(136;0.192)			CTGCTTGAAAGGAGTTGTAGT	0.353000													29	45					0	0	0.750413	0	0
PTCD3	55037	broad.mit.edu	37	2	86344203	86344203	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr2:86344203C>T	ENST00000254630.7	+	6	401	c.335C>T	c.(334-336)tCc>tTc	p.S112F	PTCD3_ENST00000409277.3_Missense_Mutation_p.S112F|PTCD3_ENST00000465560.1_3'UTR	NM_017952.5	NP_060422.4	Q96EY7	PTCD3_HUMAN	pentatricopeptide repeat domain 3	112						mitochondrion	protein binding			NS(1)|breast(2)|endometrium(3)|kidney(4)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)	22						GCAAAGAAATCCGGGGAGAAT	0.328000													4	12					0	0	0.150653	0	0
TUBGCP6	85378	broad.mit.edu	37	22	50660946	50660946	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr22:50660946G>A	ENST00000439308.2	-	14	2838	c.2346C>T	c.(2344-2346)atC>atT	p.I782I	TUBGCP6_ENST00000248846.5_Silent_p.I782I|TUBGCP6_ENST00000491449.1_5'UTR	NM_020461.3	NP_065194.2	Q96RT7	GCP6_HUMAN	tubulin, gamma complex associated protein 6	782					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(4)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(13)|ovary(3)|prostate(2)|skin(2)	45		all_cancers(38;5.79e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.109)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GGTGCCTCTGGATTCTCCACA	0.562000													13	23					0	0	0.411799	0	0
ATP8B4	79895	broad.mit.edu	37	15	50152518	50152518	+	Missense_Mutation	SNP	T	T	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr15:50152518T>A	ENST00000284509.6	-	28	3593	c.3452A>T	c.(3451-3453)aAa>aTa	p.K1151I	ATP8B4_ENST00000559829.1_Missense_Mutation_p.K1151I	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	1151					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		GGGTGGATTTTTAGCTCGCAT	0.448000													19	59					0	0	0.539581	0	0
CHRNG	1146	broad.mit.edu	37	2	233409127	233409127	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr2:233409127G>A	ENST00000389494.3	+	10	1107	c.1086G>A	c.(1084-1086)ctG>ctA	p.L362L	CHRNG_ENST00000389492.3_Silent_p.L310L	NM_005199.4	NP_005190.4	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma (muscle)	362					muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity			breast(2)|endometrium(3)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)	22		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		TTCGCCCGCTGGCCCCGGCAG	0.652000													32	81					0	0	0.769981	0	0
ZNF564	163050	broad.mit.edu	37	19	12638475	12638475	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr19:12638475G>A	ENST00000339282.7	-	4	643	c.447C>T	c.(445-447)gcC>gcT	p.A149A	ZNF709_ENST00000428311.1_Intron|CTD-2192J16.20_ENST00000593682.1_3'UTR	NM_144976.3	NP_659413.1			zinc finger protein 564											endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	18						AAGAACTGAAGGCTTTCCCAC	0.433000													18	22					0	0	0.539581	0	0
LRGUK	136332	broad.mit.edu	37	7	133943150	133943150	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr7:133943150C>T	ENST00000285928.2	+	19	2409	c.2340C>T	c.(2338-2340)acC>acT	p.T780T		NM_144648.1	NP_653249.1	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain containing	780							ATP binding|kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	49						CCGAAGAGACCCGGAAAGGTA	0.562000													20	22					0	0	0.557998	0	0
KRT3	3850	broad.mit.edu	37	12	53189266	53189266	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr12:53189266G>A	ENST00000417996.2	-	1	635	c.561C>T	c.(559-561)atC>atT	p.I187I	KRT3_ENST00000309505.3_Silent_p.I187I	NM_057088.2	NP_476429.2	P12035	K2C3_HUMAN	keratin 3	187	Head.			I -> T (in Ref. 1; CAA28991).	epithelial cell differentiation|intermediate filament cytoskeleton organization	keratin filament	structural molecule activity			NS(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|skin(1)	23						TCTGGGGGTCGATCTCCACAT	0.542000													22	26					0	0	0.624587	0	0
DNAH17	8632	broad.mit.edu	37	17	76533472	76533472	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr17:76533472C>T	ENST00000389840.5	-	19	2892	c.2768G>A	c.(2767-2769)gGc>gAc	p.G923D	DNAH17_ENST00000585328.1_Missense_Mutation_p.G920D					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TGCCAGGAAGCCGCGATCTGA	0.587000													4	4					0	0	0.217242	0	0
IARS2	55699	broad.mit.edu	37	1	220275523	220275523	+	Silent	SNP	T	T	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr1:220275523T>C	ENST00000366922.1	+	4	718	c.387T>C	c.(385-387)cgT>cgC	p.R129R	IARS2_ENST00000302637.5_Silent_p.R201R			Q9NSE4	SYIM_HUMAN	isoleucyl-tRNA synthetase 2, mitochondrial	201					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			NS(1)|breast(1)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(17)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	CATTTATTCGTTGGGGAATAA	0.313000													16	40					0	0	0.557998	0	0
PTPRB	5787	broad.mit.edu	37	12	71016398	71016398	+	Missense_Mutation	SNP	C	C	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr12:71016398C>A	ENST00000334414.6	-	3	524	c.480G>T	c.(478-480)agG>agT	p.R160S	PTPRB_ENST00000551525.1_Missense_Mutation_p.R159S|PTPRB_ENST00000550358.1_Missense_Mutation_p.R160S|PTPRB_ENST00000538174.2_5'UTR	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	0	Fibronectin type-III 2.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TTCTAGTGCTCCTCACCGAAA	0.413000													6	4					0.00198382	0.00203602	0.248553	1	0
ZC3H14	79882	broad.mit.edu	37	14	89061145	89061145	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr14:89061145C>T	ENST00000555900.1	+	1	387	c.75C>T	c.(73-75)tcC>tcT	p.S25S	ZC3H14_ENST00000406216.3_Silent_p.S25S|ZC3H14_ENST00000555755.1_Intron|ZC3H14_ENST00000556945.1_Intron|ZC3H14_ENST00000302216.8_Intron|ZC3H14_ENST00000336693.4_Intron|ZC3H14_ENST00000359301.3_Intron|ZC3H14_ENST00000557607.1_Intron|ZC3H14_ENST00000393514.5_Intron|ZC3H14_ENST00000318308.6_Silent_p.S25S|ZC3H14_ENST00000251038.5_Intron			Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14	0						cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(1)|skin(2)	21						ACTTAGGTTCCATAACAAGCT	0.393000													34	43					0	0	0.796494	0	0
NEK1	4750	broad.mit.edu	37	4	170327855	170327855	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr4:170327855C>T	ENST00000439128.2	-	30	3822	c.3182G>A	c.(3181-3183)aGa>aAa	p.R1061K	NEK1_ENST00000512193.1_Missense_Mutation_p.R992K|NEK1_ENST00000511633.1_Missense_Mutation_p.R1045K|NEK1_ENST00000507142.1_Missense_Mutation_p.R1089K|NEK1_ENST00000510533.1_Missense_Mutation_p.R1017K	NM_012224.2	NP_036356.1	Q96PY6	NEK1_HUMAN	NIMA-related kinase 1	1061					cell division|cilium assembly|mitosis	nucleus|pericentriolar material	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(1)|breast(3)|endometrium(3)|kidney(2)|large_intestine(13)|lung(18)|ovary(2)|prostate(2)|stomach(1)	45		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)|KIRC - Kidney renal clear cell carcinoma(143;0.0325)|Kidney(143;0.0385)|LUSC - Lung squamous cell carcinoma(193;0.14)		CATAAGGGTTCTGAACAGCTT	0.318000													23	29					0	0	0.717897	0	0
SHF	90525	broad.mit.edu	37	15	45464403	45464403	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr15:45464403C>T	ENST00000290894.8	-	6	1401	c.907G>A	c.(907-909)Gag>Aag	p.E303K	SHF_ENST00000560540.1_Missense_Mutation_p.E321K|SHF_ENST00000560734.1_Intron|RP11-519G16.2_ENST00000560034.1_RNA|SHF_ENST00000560471.1_Missense_Mutation_p.E368K|SHF_ENST00000458022.2_Missense_Mutation_p.E119K|SHF_ENST00000318390.6_Missense_Mutation_p.E313K	NM_138356.2	NP_612365.2	B3KTY1	B3KTY1_HUMAN	Src homology 2 domain containing F	303										endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(2)	12		all_cancers(109;8.13e-11)|all_epithelial(112;6.29e-09)|Lung NSC(122;3.57e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.1e-16)|GBM - Glioblastoma multiforme(94;5.98e-06)		CTGCTGGGCTCCATGCTTAGG	0.642000													23	40					0	0	0.667858	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110376846	110376846	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr8:110376846G>A	ENST00000378402.5	+	2	248	c.144G>A	c.(142-144)agG>agA	p.R48R		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	48	IPT/TIG 1.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GAGCAACAAGGCTGACTATAA	0.328000										HNSCC(38;0.096)			5	6					0	0	0.184627	0	0
OR2B11	127623	broad.mit.edu	37	1	247615087	247615087	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr1:247615087G>A	ENST00000318749.6	-	1	221	c.198C>T	c.(196-198)ttC>ttT	p.F66F		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	66					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GGTGACTGAGGAAGATGTACA	0.572000													18	73					0	0	0.608945	0	0
SIM1	6492	broad.mit.edu	37	6	100897319	100897319	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr6:100897319C>T	ENST00000369208.3	-	6	1245	c.463G>A	c.(463-465)Gag>Aag	p.E155K	SIM1_ENST00000262901.4_Missense_Mutation_p.E155K			P81133	SIM1_HUMAN	single-minded family bHLH transcription factor 1	155					cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(1)|large_intestine(15)|lung(34)|ovary(4)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	79		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CGCTCGATCTCATACTCTGGG	0.592000													15	16					0	0	0.500413	0	0
CYP46A1	10858	broad.mit.edu	37	14	100157478	100157478	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr14:100157478C>T	ENST00000261835.3	+	2	284	c.180C>T	c.(178-180)ctC>ctT	p.L60L	CYP46A1_ENST00000423126.2_5'UTR	NM_006668.1	NP_006659.1	Q9Y6A2	CP46A_HUMAN	cytochrome P450, family 46, subfamily A, polypeptide 1	60					bile acid biosynthetic process|cholesterol catabolic process|nervous system development|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol 24-hydroxylase activity|electron carrier activity|heme binding|steroid hydroxylase activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(12)|prostate(1)|skin(1)	25		Melanoma(154;0.0866)|all_epithelial(191;0.179)				GCCGTGTGCTCCAAGATGTGT	0.502000													28	51					0	0	0.750413	0	0
TET1	80312	broad.mit.edu	37	10	70406332	70406332	+	Silent	SNP	T	T	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr10:70406332T>C	ENST00000373644.4	+	4	4055	c.3846T>C	c.(3844-3846)taT>taC	p.Y1282Y		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	1282					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						ATAAAGCTTATAATTCTCAGG	0.458000													6	39					0	0	0.248553	0	0
SLC52A3	113278	broad.mit.edu	37	20	744419	744419	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr20:744419G>A	ENST00000381944.3	-	3	1037	c.796C>T	c.(796-798)Cgg>Tgg	p.R266W	SLC52A3_ENST00000217254.7_Missense_Mutation_p.R266W|SLC52A3_ENST00000473664.1_Intron			Q9NQ40	RFT2_HUMAN	solute carrier family 52 (riboflavin transporter), member 3	266					sensory perception of sound	integral to plasma membrane	riboflavin transporter activity										TCCCGCGGCCGGATGGAGTGG	0.647000													22	29					0	0	0.624587	0	0
USP40	55230	broad.mit.edu	37	2	234434202	234434202	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr2:234434202C>T	ENST00000251722.6	-	14	1846	c.1729G>A	c.(1729-1731)Gaa>Aaa	p.E577K	USP40_ENST00000427112.2_Missense_Mutation_p.E577K|USP40_ENST00000450966.1_Missense_Mutation_p.E589K			Q9NVE5	UBP40_HUMAN	ubiquitin specific peptidase 40	577					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|endometrium(6)|kidney(5)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		TCCCAAAATTCTAACAGCTGA	0.368000													28	18					0	0	0.717897	0	0
HLCS	3141	broad.mit.edu	37	21	38269242	38269242	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr21:38269242G>A	ENST00000399120.1	-	7	2599	c.1369C>T	c.(1369-1371)Cgc>Tgc	p.R457C	HLCS_ENST00000336648.3_Missense_Mutation_p.R457C|HLCS_ENST00000482273.1_5'UTR	NM_001242784.1	NP_001229713.1	P50747	BPL1_HUMAN	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)	457					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	AGATTTTGGCGATAGATCTCT	0.468000													10	35					0	0	0.335167	0	0
GPR112	139378	broad.mit.edu	37	X	135494509	135494509	+	Silent	SNP	A	A	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chrX:135494509A>C	ENST00000394143.1	+	24	9312	c.9021A>C	c.(9019-9021)cgA>cgC	p.R3007R	GPR112_ENST00000287534.4_Intron|GPR112_ENST00000394141.1_Silent_p.R2802R|GPR112_ENST00000370652.1_Silent_p.R3007R|GPR112_ENST00000412101.1_Silent_p.R2802R	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	3007					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					GGTGGTTGCGATTGGATAACT	0.403000													36	2					0	0	0.788014	0	0
TIMELESS	8914	broad.mit.edu	37	12	56814625	56814625	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr12:56814625G>A	ENST00000229201.4	-	25	3232	c.3078C>T	c.(3076-3078)atC>atT	p.I1026I	TIMELESS_ENST00000554616.1_Silent_p.I524I|TIMELESS_ENST00000553532.1_Silent_p.I1027I	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	1027					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						CAGCTGCTCGGATCAGGCAGT	0.527000													14	44					0	0	0.520397	0	0
CPAMD8	27151	broad.mit.edu	37	19	17025308	17025308	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr19:17025308C>T	ENST00000443236.1	-	29	3959	c.3927_splice	c.e29-1	p.G1310_splice		NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	1263						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						TGGATCCCACCCTGCAAGGGG	0.612000													18	18					0	0	0.539581	0	0
SLC34A2	10568	broad.mit.edu	37	4	25676182	25676182	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr4:25676182C>T	ENST00000382051.3	+	12	1439	c.1389C>T	c.(1387-1389)atC>atT	p.I463I	SLC34A2_ENST00000503434.1_Silent_p.I462I|SLC34A2_ENST00000504570.1_Silent_p.I462I	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	463					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				GCTCCAACATCGGCACCACCA	0.592000			T	ROS1	NSCLC								19	64					0	0	0.557998	0	0
CPD	1362	broad.mit.edu	37	17	28789002	28789002	+	Silent	SNP	T	T	G			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr17:28789002T>G	ENST00000225719.4	+	19	3814	c.3738T>G	c.(3736-3738)ggT>ggG	p.G1246G	CPD_ENST00000543464.2_Silent_p.G999G	NM_001304.4	NP_001295.2	O75976	CBPD_HUMAN	carboxypeptidase D	1246	Carboxypeptidase-like 3.				proteolysis	integral to membrane	metallocarboxypeptidase activity|serine-type carboxypeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|liver(1)|lung(13)|skin(5)|stomach(1)|urinary_tract(1)	36						AAGAGGGAGGTTATTTCCATG	0.393000													20	10					0	0	0.557998	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147027949	147027949	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr5:147027949C>T	ENST00000265272.5	-	5	1393	c.926G>A	c.(925-927)cGa>cAa	p.R309Q	JAKMIP2_ENST00000507386.1_Missense_Mutation_p.R309Q|JAKMIP2_ENST00000333010.6_Missense_Mutation_p.R267Q	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	309						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAGTTCATTTCGTTCATCTCC	0.303000													17	46					0	0	0.520397	0	0
PWP1	11137	broad.mit.edu	37	12	108090340	108090340	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr12:108090340C>T	ENST00000412830.3	+	6	760	c.592C>T	c.(592-594)Cct>Tct	p.P198S	PWP1_ENST00000541166.1_Missense_Mutation_p.P136S	NM_007062.1	NP_008993.1	Q13610	PWP1_HUMAN	PWP1 homolog (S. cerevisiae)	198					transcription, DNA-dependent	nucleus				breast(3)|endometrium(4)|kidney(1)|large_intestine(8)|lung(6)|urinary_tract(1)	23						GAATTTTGATCCTAGCCCAGA	0.333000													19	31					0	0	0.575678	0	0
MIS18BP1	55320	broad.mit.edu	37	14	45687484	45687484	+	Splice_Site	SNP	C	C	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr14:45687484C>A	ENST00000310806.4	-	12	3301		c.e12+1			NM_018353.4	NP_060823.3	Q6P0N0	M18BP_HUMAN	MIS18 binding protein 1						cell division|CenH3-containing nucleosome assembly at centromere|mitosis	chromosome, centromeric region|nucleoplasm	DNA binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	39						ACGAAGGTTACCATTTTGGCC	0.353000													38	65					1.32136e-16	1.38529e-16	0.840704	1	0
HERC2P3	283755	broad.mit.edu	37	15	20588496	20588496	+	RNA	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr15:20588496C>T	ENST00000428453.1	-	0	4254																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						ATCAACACTTCCCTAGGGAAA	0.493000													8	6					0	0	0.278610	0	0
RHAG	6005	broad.mit.edu	37	6	49604381	49604381	+	Missense_Mutation	SNP	C	C	T	rs141969178		TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr6:49604381C>T	ENST00000371175.4	-	1	171	c.145G>A	c.(145-147)Gag>Aag	p.E49K	RHAG_ENST00000229810.7_Missense_Mutation_p.E49K	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	49					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					GGATATAACTCAAAGAATATG	0.368000													38	53					0	0	0.840704	0	0
EFCAB11	90141	broad.mit.edu	37	14	90263603	90263603	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr14:90263603C>T	ENST00000316738.7	-	6	504	c.476G>A	c.(475-477)gGa>gAa	p.G159E	EFCAB11_ENST00000556609.1_Missense_Mutation_p.G111E|RP11-33N16.3_ENST00000555070.1_RNA|EFCAB11_ENST00000555872.1_Missense_Mutation_p.G135E	NM_145231.2	NP_660274.1	Q9BUY7	EFC11_HUMAN	EF-hand calcium binding domain 11	159	EF-hand 3.						calcium ion binding			large_intestine(1)|lung(1)	2						TTCCTTCTGTCCATAGTTCAG	0.388000													8	38					0	0	0.278610	0	0
OR9K2	441639	broad.mit.edu	37	12	55524316	55524316	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr12:55524316C>T	ENST00000305377.5	+	1	852	c.764C>T	c.(763-765)tCt>tTt	p.S255F		NM_001005243.1	NP_001005243.1	Q8NGE7	OR9K2_HUMAN	olfactory receptor, family 9, subfamily K, member 2	255					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(3)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(14)|pancreas(1)|prostate(2)|skin(2)	31						AAGATACATTCTACTGAGGGA	0.383000													8	47					0	0	0.278610	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86548562	86548562	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr7:86548562G>A	ENST00000450689.2	-	11	1649	c.1464C>T	c.(1462-1464)atC>atT	p.I488I	KIAA1324L_ENST00000444627.1_Silent_p.I488I|KIAA1324L_ENST00000297222.6_Silent_p.I248I|KIAA1324L_ENST00000490995.1_5'UTR|KIAA1324L_ENST00000416314.1_Silent_p.I321I	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	488						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					GCAAGTTTAAGATCAGGTAAT	0.363000													16	26					0	0	0.624587	0	0
PARD3	56288	broad.mit.edu	37	10	34663808	34663808	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr10:34663808C>T	ENST00000374789.3	-	11	1987	c.1662G>A	c.(1660-1662)agG>agA	p.R554R	PARD3_ENST00000340077.5_Silent_p.R554R|PARD3_ENST00000544292.1_Silent_p.R284R|PARD3_ENST00000374773.1_Silent_p.R554R|PARD3_ENST00000374776.1_Silent_p.R554R|PARD3_ENST00000346874.4_Silent_p.R554R|PARD3_ENST00000545693.1_Silent_p.R554R|PARD3_ENST00000545260.1_Silent_p.R510R|PARD3_ENST00000350537.4_Silent_p.R554R|PARD3_ENST00000374794.3_Silent_p.R510R|PARD3_ENST00000374788.3_Silent_p.R554R|PARD3_ENST00000374790.3_Silent_p.R510R	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	554					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				ACACCAGTTCCCTTGGGTGGA	0.463000													37	78					0	0	0.812448	0	0
RPAP1	26015	broad.mit.edu	37	15	41819403	41819403	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr15:41819403T>C	ENST00000304330.4	-	13	1824	c.1708A>G	c.(1708-1710)Atc>Gtc	p.I570V	RPAP1_ENST00000561603.1_Missense_Mutation_p.I570V	NM_015540.2	NP_056355.2	Q9BWH6	RPAP1_HUMAN	RNA polymerase II associated protein 1	570						nucleus	DNA binding|DNA-directed RNA polymerase activity			NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(6)|lung(16)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	45		all_cancers(109;6.59e-20)|all_epithelial(112;7.67e-17)|Lung NSC(122;5.34e-11)|all_lung(180;4.17e-10)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		OV - Ovarian serous cystadenocarcinoma(18;2.84e-17)|GBM - Glioblastoma multiforme(113;1.68e-06)|Colorectal(105;0.0163)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GCCAGGCGGATGAGCACAGCC	0.617000													17	13					0	0	0.557998	0	0
NUTM1	256646	broad.mit.edu	37	15	34649344	34649344	+	Silent	SNP	C	C	T	rs7163178		TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr15:34649344C>T	ENST00000537011.1	+	8	3517	c.3135C>T	c.(3133-3135)ctC>ctT	p.L1045L	NUTM1_ENST00000333756.4_Silent_p.L1017L|NUTM1_ENST00000438749.3_Silent_p.L1035L					NUT midline carcinoma, family member 1																		ATGAGGAACTCTCCAACTTTG	0.502000													10	26					0	0	0.361761	0	0
FAM86HP	729375	broad.mit.edu	37	3	129821661	129821661	+	RNA	SNP	T	T	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr3:129821661T>C	ENST00000500074.2	-	0	484																											GTAAAGGCCATGTAGACCTCA	0.667000													8	46					0	0	0.411799	0	0
NKAIN3	286183	broad.mit.edu	37	8	63659653	63659653	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr8:63659653G>A	ENST00000523211.1	+	4	568	c.436G>A	c.(436-438)Gag>Aag	p.E146K	NKAIN3_ENST00000328472.5_Missense_Mutation_p.E146K|NKAIN3_ENST00000519049.1_3'UTR	NM_173688.2	NP_775959.1	Q8N8D7	NKAI3_HUMAN	Na+/K+ transporting ATPase interacting 3	146						integral to membrane|plasma membrane				kidney(3)|large_intestine(2)|lung(8)	13	Breast(64;0.127)	Lung NSC(129;0.187)				CCAGTACCTGGAGGTCATCCA	0.468000													22	16					0	0	0.624587	0	0
NPSR1	387129	broad.mit.edu	37	7	34698043	34698043	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr7:34698043G>A	ENST00000360581.1	+	1	147	c.19G>A	c.(19-21)Gag>Aag	p.E7K	NPSR1_ENST00000359791.1_Missense_Mutation_p.E7K|AC005493.1_ENST00000399077.1_Intron|NPSR1-AS1_ENST00000419766.1_RNA|NPSR1_ENST00000531252.1_Missense_Mutation_p.E7K|NPSR1_ENST00000381539.3_Missense_Mutation_p.E7K|NPSR1_ENST00000381542.1_Missense_Mutation_p.E7K|NPSR1_ENST00000465305.1_Missense_Mutation_p.E7K|NPSR1_ENST00000381553.3_Missense_Mutation_p.E7K	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	7						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	CAACTTCACAGAGGGCAGCTT	0.582000													27	34					0	0	0.706142	0	0
KCNT2	343450	broad.mit.edu	37	1	196309582	196309582	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr1:196309582C>T	ENST00000367433.5	-	16	1773	c.1672G>A	c.(1672-1674)Gaa>Aaa	p.E558K	KCNT2_ENST00000294725.8_Missense_Mutation_p.E558K|KCNT2_ENST00000451324.2_Missense_Mutation_p.E169K|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000367431.4_Missense_Mutation_p.E508K			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	558						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						GAATTCTCTTCTTTGGTAATA	0.353000													8	31					0	0	0.307466	0	0
DCLK3	85443	broad.mit.edu	37	3	36759615	36759615	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr3:36759615G>A	ENST00000416516.2	-	4	2129	c.1639C>T	c.(1639-1641)Ctg>Ttg	p.L547L	DCLK3_ENST00000498047.1_5'UTR	NM_033403.1	NP_208382.1	Q9C098	DCLK3_HUMAN	doublecortin-like kinase 3	547	Protein kinase.					cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			breast(3)|endometrium(3)|kidney(2)|large_intestine(11)|lung(20)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	48						AAGCCACACAGCAGGATATAG	0.577000													39	52					0	0	0.853193	0	0
TGM6	343641	broad.mit.edu	37	20	2411160	2411160	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr20:2411160C>T	ENST00000202625.2	+	11	1808	c.1747C>T	c.(1747-1749)Ctg>Ttg	p.L583L	TGM6_ENST00000381423.1_Silent_p.L583L	NM_198994.2	NP_945345.2	O95932	TGM3L_HUMAN	transglutaminase 6	583					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|endometrium(6)|kidney(2)|large_intestine(2)|lung(32)|ovary(4)|prostate(1)|skin(4)	52					L-Glutamine(DB00130)	CAAGAAGATCCTGTTGGCTGC	0.473000													23	23					0	0	0.608945	0	0
ANKH	56172	broad.mit.edu	37	5	14758614	14758614	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr5:14758614G>A	ENST00000284268.6	-	3	737	c.407C>T	c.(406-408)gCc>gTc	p.A136V		NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	136					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						AGGAAAGGCGGCGAGGTACAG	0.418000													9	21					0	0	0.335167	0	0
GPR123	84435	broad.mit.edu	37	10	134909255	134909255	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr10:134909255G>A	ENST00000607359.1	+	11	2134	c.2134G>A	c.(2134-2136)Ggc>Agc	p.G712S	GPR123_ENST00000392607.3_Intron			Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	0						integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(3)	14		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		GGAGCTCTCGGGCCCGCTGGC	0.657000													4	11					0	0	0.150653	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				33	38					0	0	0.769981	0	0
MAGI2	9863	broad.mit.edu	37	7	77708388	77708388	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr7:77708388G>A	ENST00000354212.4	-	21	3835	c.3582C>T	c.(3580-3582)atC>atT	p.I1194I	MAGI2_ENST00000522391.1_Silent_p.I1194I|MAGI2_ENST00000419488.1_Silent_p.I1180I	NM_012301.3	NP_036433.2	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 2	1194	PDZ 6.					cell junction|synapse|synaptosome	phosphatase binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(37)|ovary(5)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)|urinary_tract(3)	84		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				TGATTTCAATGATTTGATCTC	0.393000													76	115					0	0	0.870114	0	0
KIAA2022	340533	broad.mit.edu	37	X	73962141	73962141	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chrX:73962141C>T	ENST00000373468.1	-	3	2902	c.2251G>A	c.(2251-2253)Gaa>Aaa	p.E751K	KIAA2022_ENST00000055682.5_Missense_Mutation_p.E751K			Q5QGS0	K2022_HUMAN	KIAA2022	751					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(23)|liver(1)|lung(41)|ovary(7)|pancreas(2)|prostate(4)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	109						GATTGGTTTTCCAAGAGAGGG	0.378000													45	5					0	0	0.847076	0	0
BAD	572	broad.mit.edu	37	11	64037604	64037604	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr11:64037604G>A	ENST00000544785.1	-	2	393	c.393C>T	c.(391-393)ttC>ttT	p.F131F	BAD_ENST00000394532.3_3'UTR|BAD_ENST00000309032.3_3'UTR			Q92934	BAD_HUMAN	BCL2-associated agonist of cell death	0					activation of pro-apoptotic gene products|ADP metabolic process|ATP metabolic process|cellular response to hypoxia|cellular response to mechanical stimulus|cellular response to nicotine|glucose homeostasis|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|pore complex assembly|positive regulation of epithelial cell proliferation|positive regulation of glucokinase activity|positive regulation of insulin secretion|positive regulation of mitochondrial membrane potential|positive regulation of type B pancreatic cell development|regulation of mitochondrial membrane permeability|type B pancreatic cell proliferation	cytosol|mitochondrial outer membrane	caspase activator activity|phospholipid binding|protein kinase binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(1)	4						AGGCCTGAGGGAAGTACTTCC	0.602000													5	20					0	0	0.184627	0	0
CHRDL2	25884	broad.mit.edu	37	11	74415556	74415556	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr11:74415556G>A	ENST00000376332.3	-	7	1222	c.726C>T	c.(724-726)atC>atT	p.I242I	CHRDL2_ENST00000263671.5_Silent_p.I242I|CHRDL2_ENST00000534159.1_5'UTR	NM_001278473.1	NP_001265402.1	Q6WN34	CRDL2_HUMAN	chordin-like 2	242					cartilage development|cell differentiation|ossification	extracellular region|mitochondrion				endometrium(1)|kidney(1)|large_intestine(6)|lung(4)|prostate(1)|skin(2)	15	Hepatocellular(1;0.098)					CCTTCAGGACGATCTTGACAG	0.637000													14	37					0	0	0.457914	0	0
SYT10	341359	broad.mit.edu	37	12	33579303	33579303	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr12:33579303G>A	ENST00000228567.3	-	2	575	c.279C>T	c.(277-279)atC>atT	p.I93I	SYT10_ENST00000535526.1_5'UTR	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	93						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					GAAGCGTAGTGATGTTGGAAG	0.423000													13	18					0	0	0.435327	0	0
PLXNA4	91584	broad.mit.edu	37	7	131866242	131866242	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr7:131866242G>A	ENST00000359827.3	-	18	4352	c.3390C>T	c.(3388-3390)atC>atT	p.I1130I	PLXNA4_ENST00000321063.4_Silent_p.I1130I			Q9HCM2	PLXA4_HUMAN	plexin A4	1130	IPT/TIG 3.					integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						TCTTGTTGAGGATGAGCAGGG	0.592000													51	87					0	0	0.870114	0	0
BRF1	2972	broad.mit.edu	37	14	105677571	105677571	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr14:105677571C>T	ENST00000546474.1	-	17	16843	c.1884G>A	c.(1882-1884)ctG>ctA	p.L628L	BRF1_ENST00000379932.4_Intron|BRF1_ENST00000379937.2_Silent_p.L601L|BRF1_ENST00000327359.3_Silent_p.L513L|BRF1_ENST00000551787.1_Intron|BRF1_ENST00000547530.1_Silent_p.L154L|BRF1_ENST00000446501.2_Silent_p.L390L|BRF1_ENST00000440513.3_Silent_p.L535L|BRF1_ENST00000392557.4_Silent_p.L424L	NM_001242787.1|NM_001519.3	NP_001229716.1|NP_001510.2	Q92994	TF3B_HUMAN	BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit	628					positive regulation of transcription, DNA-dependent|rRNA transcription|transcription initiation from RNA polymerase III promoter|tRNA transcription	transcription factor TFIIIB complex	translation initiation factor activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0231)|all_epithelial(191;0.0694)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00753)|all cancers(16;0.00925)|Epithelial(46;0.0221)	Epithelial(152;0.14)		CGCTCTCCACCAGCACCGCCT	0.672000													42	40					0	0	0.840704	0	0
PCDHB8	56128	broad.mit.edu	37	5	140559978	140559978	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr5:140559978C>T	ENST00000239444.2	+	1	2608	c.2363C>T	c.(2362-2364)tCt>tTt	p.S788F		NM_019120.3	NP_061993.2	Q9UN66	PCDB8_HUMAN		788					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(2)|endometrium(5)|kidney(6)|large_intestine(14)|liver(1)|lung(38)|prostate(6)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAACAAAACTCTAACTTTAGG	0.368000													14	37					0	0	0.457914	0	0
FAM66D	100132923	broad.mit.edu	37	8	11985905	11985905	+	RNA	SNP	C	C	G			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr8:11985905C>G	ENST00000434078.2	+	0	608					NR_027425.1																						TGCATGTCAACGCACTCAGGA	0.483000													3	33					0	0	0.115264	0	0
FARSA	2193	broad.mit.edu	37	19	13041108	13041108	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr19:13041108C>T	ENST00000588025.1	-	5	692	c.552G>A	c.(550-552)cgG>cgA	p.R184R	FARSA_ENST00000314606.4_Silent_p.R144R|FARSA_ENST00000423140.2_Silent_p.R144R			Q9Y285	SYFA_HUMAN	phenylalanyl-tRNA synthetase, alpha subunit	144					phenylalanyl-tRNA aminoacylation	cytosol|soluble fraction	ATP binding|phenylalanine-tRNA ligase activity|protein binding|tRNA binding			NS(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(9)|ovary(3)|upper_aerodigestive_tract(1)	20					L-Phenylalanine(DB00120)	CCTGTCCCCCCCGGACCAGCT	0.652000													36	13					0	0	0.769981	0	0
GRIK1	2897	broad.mit.edu	37	21	30927444	30927444	+	Missense_Mutation	SNP	G	G	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr21:30927444G>T	ENST00000399914.1	-	15	3012	c.2491C>A	c.(2491-2493)Ctg>Atg	p.L831M	GRIK1_ENST00000399909.1_Missense_Mutation_p.L831M|GRIK1_ENST00000389124.2_Missense_Mutation_p.L846M|GRIK1_ENST00000309434.7_Missense_Mutation_p.L848M|GRIK1_ENST00000327783.4_Missense_Mutation_p.L846M|GRIK1_ENST00000399907.1_Missense_Mutation_p.L846M|GRIK1_ENST00000535441.1_Missense_Mutation_p.L848M|GRIK1_ENST00000399913.1_Missense_Mutation_p.L846M|GRIK1_ENST00000389125.3_Missense_Mutation_p.L831M			P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	846					central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(11)|lung(18)|ovary(1)|prostate(4)|skin(1)|stomach(1)|urinary_tract(1)	45					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	GAAAGGACCAGTCCGGCAGCC	0.463000													10	71					7.48243e-07	7.76103e-07	0.335167	1	0
C15orf54	400360	broad.mit.edu	37	15	39544719	39544719	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr15:39544719G>A	ENST00000318578.3	+	2	751	c.383G>A	c.(382-384)gGg>gAg	p.G128E	RP11-624L4.1_ENST00000558209.1_RNA|RP11-624L4.1_ENST00000560484.1_RNA|C15orf54_ENST00000561223.1_Missense_Mutation_p.G128E|RP11-624L4.1_ENST00000561058.1_RNA	NM_207445.2	NP_997328.1	Q8N8G6	CO054_HUMAN	chromosome 15 open reading frame 54	128										NS(1)|haematopoietic_and_lymphoid_tissue(2)|lung(2)	5		all_cancers(109;5.39e-14)|all_epithelial(112;3.14e-12)|Lung NSC(122;9.74e-10)|all_lung(180;2.23e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;1.19e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0706)		CAGTCTCCTGGGTGGAAGAAC	0.468000													27	71					0	0	0.706142	0	0
TUBA4B	80086	broad.mit.edu	37	2	220136823	220136823	+	RNA	SNP	A	A	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr2:220136823A>T	ENST00000490341.1	+	0	1293					NR_003063.1																						GTGGGCATGGATAGTGTGGAG	0.517000													3	7					0	0	0.115264	0	0
GPRC5C	55890	broad.mit.edu	37	17	72436813	72436813	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr17:72436813G>A	ENST00000392627.1	+	2	2159	c.1033G>A	c.(1033-1035)Gtc>Atc	p.V345I	GPRC5C_ENST00000481232.1_Intron|GPRC5C_ENST00000392629.2_Missense_Mutation_p.V312I|GPRC5C_ENST00000342648.5_Intron	NM_022036.2	NP_071319.2	Q9NQ84	GPC5C_HUMAN	G protein-coupled receptor, family C, group 5, member C	300						cytoplasmic vesicle membrane|integral to plasma membrane	G-protein coupled receptor activity|protein binding			central_nervous_system(1)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	17						CATCCCCGAGGTCTCCCAGGT	0.627000													36	35					0	0	0.788014	0	0
SLC25A53	401612	broad.mit.edu	37	X	103349514	103349514	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chrX:103349514G>A	ENST00000357421.4	-	2	607	c.427C>T	c.(427-429)Cag>Tag	p.Q143*		NM_001012755.3	NP_001012773.2	Q5H9E4	MCAR6_HUMAN	solute carrier family 25, member 53	143					transport	integral to membrane|mitochondrial inner membrane											CGACCATCCTGGAGCACATTT	0.597000													105	10					0	0	0.870114	0	0
RLTPR	146206	broad.mit.edu	37	16	67685655	67685655	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr16:67685655G>A	ENST00000334583.6	+	25	2823	c.2495G>A	c.(2494-2496)tGg>tAg	p.W832*	RLTPR_ENST00000545661.1_Nonsense_Mutation_p.W796*	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	832										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		GGATCCAGCTGGAGGGAGCAG	0.612000													7	2					0	0	0.248553	0	0
CR1	1378	broad.mit.edu	37	1	207803916	207803916	+	Silent	SNP	A	A	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr1:207803916A>C	ENST00000367049.4	+	46	7407	c.7407A>C	c.(7405-7407)ggA>ggC	p.G2469G	CR1_ENST00000367053.1_Silent_p.G2019G|CR1_ENST00000367051.1_Silent_p.G2019G|CR1_ENST00000367052.1_Silent_p.G2019G|CR1_ENST00000400960.2_Silent_p.G2019G	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	2019					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						ATTCTCAAGGAGGCAGCAGCG	0.343000													4	16					0	0	0.248553	0	0
ADAMTS8	11095	broad.mit.edu	37	11	130275831	130275831	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr11:130275831C>T	ENST00000257359.6	-	9	2998	c.2292G>A	c.(2290-2292)ctG>ctA	p.L764L		NM_007037.4	NP_008968.4	Q9UP79	ATS8_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 8	764	Spacer.				negative regulation of cell proliferation|proteolysis	proteinaceous extracellular matrix	heparin binding|integrin binding|low affinity phosphate transmembrane transporter activity|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|prostate(1)|skin(1)	10	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.039)|Lung(977;0.213)		CGCTGTACTTCAGGATGGTCC	0.617000													43	29					0	0	0.840704	0	0
LIMCH1	22998	broad.mit.edu	37	4	41648871	41648871	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr4:41648871C>T	ENST00000313860.7	+	12	1680	c.1626C>T	c.(1624-1626)tcC>tcT	p.S542S	LIMCH1_ENST00000509277.1_Silent_p.S376S|LIMCH1_ENST00000512946.1_Silent_p.S542S|LIMCH1_ENST00000381753.4_Silent_p.S376S|LIMCH1_ENST00000513024.1_Silent_p.S371S|LIMCH1_ENST00000396595.3_Silent_p.S388S|LIMCH1_ENST00000512632.1_Silent_p.S542S|LIMCH1_ENST00000508501.1_Silent_p.S542S|LIMCH1_ENST00000503057.1_Silent_p.S927S|LIMCH1_ENST00000511496.1_Silent_p.S383S|LIMCH1_ENST00000514096.1_Silent_p.S383S|LIMCH1_ENST00000512820.1_Silent_p.S530S	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	542					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						AGCCTTACTCCCAGCCCAAAA	0.488000													37	45					0	0	0.819951	0	0
SHF	90525	broad.mit.edu	37	15	45470424	45470424	+	Silent	SNP	T	T	G			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr15:45470424T>G	ENST00000290894.8	-	3	878	c.384A>C	c.(382-384)ccA>ccC	p.P128P	SHF_ENST00000560540.1_Silent_p.P193P|SHF_ENST00000561091.1_5'UTR|SHF_ENST00000560734.1_Silent_p.P193P|RP11-519G16.2_ENST00000560034.1_RNA|SHF_ENST00000560471.1_Silent_p.P193P|SHF_ENST00000458022.2_5'UTR|SHF_ENST00000318390.6_Silent_p.P185P	NM_138356.2	NP_612365.2	B3KTY1	B3KTY1_HUMAN	Src homology 2 domain containing F	128										endometrium(2)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(2)	12		all_cancers(109;8.13e-11)|all_epithelial(112;6.29e-09)|Lung NSC(122;3.57e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.1e-16)|GBM - Glioblastoma multiforme(94;5.98e-06)		GGACCTTCTCTGGGGCTCCTG	0.567000													9	36					0	0	0.361761	0	0
NLN	57486	broad.mit.edu	37	5	65058797	65058797	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr5:65058797C>T	ENST00000380985.5	+	3	490	c.312C>T	c.(310-312)acC>acT	p.T104T	NLN_ENST00000502464.1_5'UTR	NM_020726.4	NP_065777.1	Q9BYT8	NEUL_HUMAN	neurolysin (metallopeptidase M3 family)	104					proteolysis	mitochondrial intermembrane space	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26		Lung NSC(167;7.21e-05)|Prostate(74;0.0174)|Ovarian(174;0.186)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0743)|Lung(70;0.00616)		TGGAAAGGACCATGCTAGACT	0.413000													16	35					0	0	0.500413	0	0
MKI67	4288	broad.mit.edu	37	10	129907335	129907335	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr10:129907335C>T	ENST00000368654.3	-	13	3144	c.2769G>A	c.(2767-2769)aaG>aaA	p.K923K	MKI67_ENST00000368653.3_Silent_p.K563K	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	923					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTTCTATTTCCTTCATCTCTC	0.348000													24	31					0	0	0.654019	0	0
CDH10	1008	broad.mit.edu	37	5	24491860	24491860	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr5:24491860C>T	ENST00000264463.4	-	11	2208	c.1701G>A	c.(1699-1701)gtG>gtA	p.V567V	CDH10_ENST00000502921.1_5'UTR	NM_006727.3	NP_006718.2	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 (T2-cadherin)	567	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(29)|lung(111)|ovary(6)|pancreas(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)	185				STAD - Stomach adenocarcinoma(35;0.0556)		TGTCTGATATCACCACAGGCA	0.398000										HNSCC(23;0.051)			23	17					0	0	0.639603	0	0
CD300A	11314	broad.mit.edu	37	17	72469802	72469802	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr17:72469802C>T	ENST00000360141.3	+	2	456	c.168C>T	c.(166-168)ttC>ttT	p.F56F	CD300A_ENST00000310828.5_Intron|CD300A_ENST00000392625.3_Intron|CD300A_ENST00000361933.3_Intron|CD300A_ENST00000577511.1_5'UTR	NM_001256841.1|NM_007261.3	NP_001243770.1|NP_009192.2	Q9UGN4	CLM8_HUMAN	CD300a molecule	56	Ig-like V-type.				cell adhesion	integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(4)|urinary_tract(1)	16						CACAGATTTTCCTATGTGACA	0.557000													14	64					0	0	0.435327	0	0
GALNT8	26290	broad.mit.edu	37	12	4848450	4848450	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr12:4848450C>T	ENST00000252318.2	+	3	968	c.631C>T	c.(631-633)Cga>Tga	p.R211*	RP11-234B24.6_ENST00000544741.2_3'UTR	NM_017417.1	NP_059113.1	Q9NY28	GALT8_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)	211	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(4)|skin(2)|urinary_tract(1)	35						GACGCCCTCTCGATTGTTGAA	0.428000													23	31					0	0	0.654019	0	0
COL5A3	50509	broad.mit.edu	37	19	10100153	10100153	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr19:10100153C>T	ENST00000264828.3	-	25	2123	c.2038G>A	c.(2038-2040)Ggc>Agc	p.G680S		NM_015719.3	NP_056534.2	P25940	CO5A3_HUMAN	collagen, type V, alpha 3	680	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			NS(2)|breast(3)|central_nervous_system(2)|endometrium(11)|kidney(23)|large_intestine(12)|liver(2)|lung(35)|ovary(8)|prostate(5)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	116			Epithelial(33;7.11e-05)			ACCAGAGGGCCATCGGATCCT	0.547000													9	14					0	0	0.335167	0	0
SH3TC1	54436	broad.mit.edu	37	4	8228944	8228944	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr4:8228944C>T	ENST00000539824.1	+	12	1669	c.1295C>T	c.(1294-1296)gCc>gTc	p.A432V	SH3TC1_ENST00000245105.3_Missense_Mutation_p.A508V|SH3TC1_ENST00000514274.1_3'UTR			Q8TE82	S3TC1_HUMAN	SH3 domain and tetratricopeptide repeats 1	508							binding			NS(1)|breast(3)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33						TTCCTGAACGCCCCTGGGTAC	0.647000													5	6					0	0	0.184627	0	0
FAM86FP	653113	broad.mit.edu	37	12	8386973	8386973	+	RNA	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr12:8386973C>T	ENST00000427893.2	-	0	793																											AGCCAGCCTCCGCAGGACCCC	0.592000													4	42					0	0	0.150653	0	0
SCAF4	57466	broad.mit.edu	37	21	33064136	33064136	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr21:33064136G>A	ENST00000286835.7	-	14	2104	c.1722C>T	c.(1720-1722)tcC>tcT	p.S574S	SCAF4_ENST00000434667.3_Silent_p.S559S|SCAF4_ENST00000399804.1_Silent_p.S574S	NM_020706.2	NP_065757.1	O95104	SFR15_HUMAN	SR-related CTD-associated factor 4	574	RRM.					nucleus	nucleotide binding|RNA binding			NS(1)|breast(2)|endometrium(9)|kidney(9)|large_intestine(11)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						GTACCTTTATGGATTTCTGGT	0.373000													14	38					0	0	0.479597	0	0
GBP6	163351	broad.mit.edu	37	1	89849796	89849796	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr1:89849796G>A	ENST00000370456.4	+	10	1706	c.1613G>A	c.(1612-1614)aGa>aAa	p.R538K	GBP6_ENST00000535065.1_Missense_Mutation_p.R408K	NM_198460.2	NP_940862.2	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	538							GTP binding|GTPase activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(11)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	42		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		CAGATGGAGAGAGAACACCTA	0.502000													11	1					0	0	0.361761	0	0
MGAM	8972	broad.mit.edu	37	7	141740561	141740561	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr7:141740561G>A	ENST00000475668.2	+	21	2467	c.2413G>A	c.(2413-2415)Gaa>Aaa	p.E805K	MGAM_ENST00000549489.2_Missense_Mutation_p.E805K			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	805	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AGTCGAGATGGAACTTCCTGG	0.478000													10	23					0	0	0.335167	0	0
LIMCH1	22998	broad.mit.edu	37	4	41648870	41648870	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr4:41648870C>T	ENST00000313860.7	+	12	1679	c.1625C>T	c.(1624-1626)tCc>tTc	p.S542F	LIMCH1_ENST00000509277.1_Missense_Mutation_p.S376F|LIMCH1_ENST00000512946.1_Missense_Mutation_p.S542F|LIMCH1_ENST00000381753.4_Missense_Mutation_p.S376F|LIMCH1_ENST00000513024.1_Missense_Mutation_p.S371F|LIMCH1_ENST00000396595.3_Missense_Mutation_p.S388F|LIMCH1_ENST00000512632.1_Missense_Mutation_p.S542F|LIMCH1_ENST00000508501.1_Missense_Mutation_p.S542F|LIMCH1_ENST00000503057.1_Missense_Mutation_p.S927F|LIMCH1_ENST00000511496.1_Missense_Mutation_p.S383F|LIMCH1_ENST00000514096.1_Missense_Mutation_p.S383F|LIMCH1_ENST00000512820.1_Missense_Mutation_p.S530F	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	542					actomyosin structure organization		actin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						AAGCCTTACTCCCAGCCCAAA	0.488000													37	45					0	0	0.819951	0	0
DMXL1	1657	broad.mit.edu	37	5	118503322	118503322	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr5:118503322A>G	ENST00000311085.8	+	23	5241	c.5161A>G	c.(5161-5163)Att>Gtt	p.I1721V	DMXL1_ENST00000539542.1_Missense_Mutation_p.I1721V	NM_005509.4	NP_005500.4	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1721										breast(3)|central_nervous_system(1)|endometrium(14)|kidney(4)|large_intestine(20)|liver(6)|lung(28)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)	86		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		ATTGAATGACATTCAGTTGGC	0.294000													8	8					0	0	0.278610	0	0
GPR39	2863	broad.mit.edu	37	2	133175121	133175121	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr2:133175121C>T	ENST00000329321.3	+	1	975	c.506C>T	c.(505-507)cCc>cTc	p.P169L		NM_001508.2	NP_001499.1	O43194	GPR39_HUMAN	G protein-coupled receptor 39	169						integral to plasma membrane	G-protein coupled receptor activity|metal ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GTGGCACTGCCCTTGCTGTTT	0.637000													14	20					0	0	0.435327	0	0
GRIK2	2898	broad.mit.edu	37	6	102483315	102483315	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr6:102483315C>T	ENST00000369138.1	+	14	2675	c.2185C>T	c.(2185-2187)Ctc>Ttc	p.L729F	GRIK2_ENST00000421544.1_Missense_Mutation_p.L729F|GRIK2_ENST00000413795.1_Missense_Mutation_p.L729F|GRIK2_ENST00000369134.4_Missense_Mutation_p.L680F|GRIK2_ENST00000318991.6_Missense_Mutation_p.L729F|GRIK2_ENST00000369137.3_Missense_Mutation_p.L653F	NM_001166247.1	NP_001159719.1	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	729					glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(37)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	CCAGCGAGTCCTCACCTCTGA	0.443000													31	93					0	0	0.750413	0	0
TAP2	6891	broad.mit.edu	37	6	32781551	32781551	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr6:32781551C>T	ENST00000452392.2	-	15	2697	c.2524G>A	c.(2524-2526)Ggg>Agg	p.G842R	HLA-DOB_ENST00000438763.2_Missense_Mutation_p.G235R			Q03519	TAP2_HUMAN	transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	0					antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent|antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent|antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent|cytosol to ER transport|intracellular transport of viral proteins in host cell|peptide antigen transport|positive regulation of antigen processing and presentation of peptide antigen via MHC class I|positive regulation of T cell mediated cytotoxicity	nucleus|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|peptide antigen-transporting ATPase activity|TAP1 binding|TAP2 binding|tapasin binding										AAGATTAGCCCAAGTAGGAAG	0.478000													3	3					0	0	0.115264	0	0
RAB2B	84932	broad.mit.edu	37	14	21931882	21931882	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr14:21931882G>A	ENST00000397762.1	-	6	507	c.407C>T	c.(406-408)gCc>gTc	p.A136V	RAB2B_ENST00000461909.1_5'UTR	NM_001163380.1|NM_032846.3	NP_001156852.1|NP_116235.2	Q8WUD1	RAB2B_HUMAN	RAB2B, member RAS oncogene family	136					protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane|plasma membrane	GTP binding			NS(1)|central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)	6	all_cancers(95;0.000858)		Epithelial(56;1.53e-06)|all cancers(55;1.44e-05)	GBM - Glioblastoma multiforme(265;0.00391)		CCTAGCAAAGGCCTCTCCTTC	0.413000													22	51					0	0	0.667858	0	0
ACCS	84680	broad.mit.edu	37	11	44100295	44100295	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr11:44100295C>T	ENST00000263776.8	+	9	1228	c.794C>T	c.(793-795)tCc>tTc	p.S265F		NM_001127219.1|NM_032592.3	NP_001120691.1|NP_115981.1	Q96QU6	1A1L1_HUMAN	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)	265							1-aminocyclopropane-1-carboxylate synthase activity|protein homodimerization activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			breast(4)|endometrium(3)|large_intestine(11)|lung(15)|ovary(1)|skin(1)	35						GATGTATACTCCCCTGAAGAG	0.587000													10	11					0	0	0.411799	0	0
TBX15	6913	broad.mit.edu	37	1	119469210	119469210	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr1:119469210C>T	ENST00000369429.3	-	3	453	c.444G>A	c.(442-444)gtG>gtA	p.V148V	TBX15_ENST00000207157.3_Silent_p.V42V			Q96SF7	TBX15_HUMAN	T-box 15	148						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		CAGTGATTTTCACTCTCATGG	0.423000													7	22					0	0	0.335167	0	0
POLR2D	5433	broad.mit.edu	37	2	128608249	128608249	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr2:128608249G>A	ENST00000272645.4	-	3	321	c.265C>T	c.(265-267)Cag>Tag	p.Q89*	POLR2D_ENST00000409955.1_Intron|POLR2D_ENST00000409698.1_Nonsense_Mutation_p.Q51*|POLR2D_ENST00000487079.1_Intron	NM_004805.3	NP_004796.1	O15514	RPB4_HUMAN	polymerase (RNA) II (DNA directed) polypeptide D	89					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA-directed RNA polymerase activity|nucleotide binding			large_intestine(1)|lung(4)|urinary_tract(1)	6	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0675)		AGCTTTTTCTGGAGtagcaag	0.363000													27	29					0	0	0.681144	0	0
FOLH1	2346	broad.mit.edu	37	11	49175820	49175820	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr11:49175820C>T	ENST00000340334.7	-	17	2171	c.1803G>A	c.(1801-1803)atG>atA	p.M601I	FOLH1_ENST00000356696.3_Missense_Mutation_p.M616I|FOLH1_ENST00000533034.1_Missense_Mutation_p.M601I|FOLH1_ENST00000343844.4_Missense_Mutation_p.M308I|FOLH1_ENST00000256999.2_Missense_Mutation_p.M616I	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	616					proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	GTGGATGTTTCATAGAAATAC	0.348000													22	29					0	0	0.639603	0	0
GPRC6A	222545	broad.mit.edu	37	6	117127589	117127589	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr6:117127589G>A	ENST00000310357.3	-	3	1300	c.1279C>T	c.(1279-1281)Cgg>Tgg	p.R427W	GPRC6A_ENST00000368549.3_Missense_Mutation_p.R427W|GPRC6A_ENST00000530250.1_Intron	NM_148963.2	NP_683766.2	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6, member A	427					response to amino acid stimulus		G-protein coupled receptor activity			autonomic_ganglia(1)|breast(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(8)|liver(1)|lung(24)|ovary(5)|pancreas(1)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)	65		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		CACAGATCCCGAATGGCATAA	0.458000													9	16					0	0	0.335167	0	0
C15orf54	400360	broad.mit.edu	37	15	39544718	39544718	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr15:39544718G>A	ENST00000318578.3	+	2	750	c.382G>A	c.(382-384)Ggg>Agg	p.G128R	RP11-624L4.1_ENST00000558209.1_RNA|RP11-624L4.1_ENST00000560484.1_RNA|C15orf54_ENST00000561223.1_Missense_Mutation_p.G128R|RP11-624L4.1_ENST00000561058.1_RNA	NM_207445.2	NP_997328.1	Q8N8G6	CO054_HUMAN	chromosome 15 open reading frame 54	128										NS(1)|haematopoietic_and_lymphoid_tissue(2)|lung(2)	5		all_cancers(109;5.39e-14)|all_epithelial(112;3.14e-12)|Lung NSC(122;9.74e-10)|all_lung(180;2.23e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;1.19e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0706)		TCAGTCTCCTGGGTGGAAGAA	0.473000													28	69					0	0	0.717897	0	0
ATG4B	23192	broad.mit.edu	37	2	242598521	242598521	+	Splice_Site	SNP	A	A	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr2:242598521A>T	ENST00000405546.3	+	7	960		c.e7-1		ATG4B_ENST00000404914.3_Splice_Site|ATG4B_ENST00000474739.2_Splice_Site|ATG4B_ENST00000402096.1_Splice_Site|ATG4B_ENST00000396411.3_Splice_Site			Q9Y4P1	ATG4B_HUMAN	autophagy related 4B, cysteine peptidase						autophagic vacuole assembly|protein transport|proteolysis	cytoplasm	cysteine-type peptidase activity|protein binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;2.44e-33)|all cancers(36;5.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;3.75e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.65e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0848)		TACTCTCTGTAGGAAGCTTGC	0.478000													4	17					0	0	0.150653	0	0
NLRP3	114548	broad.mit.edu	37	1	247587726	247587726	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr1:247587726G>A	ENST00000366497.2	+	4	1761	c.981G>A	c.(979-981)cgG>cgA	p.R327R	NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000366496.2_Silent_p.R327R|NLRP3_ENST00000336119.3_Silent_p.R327R|NLRP3_ENST00000391827.2_Silent_p.R327R|NLRP3_ENST00000391828.3_Silent_p.R327R|NLRP3_ENST00000348069.2_Silent_p.R327R	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	327	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			AGGCCGAGCGGGGAGACATTC	0.582000													18	40					0	0	0.539581	0	0
ZNF823	55552	broad.mit.edu	37	19	11832550	11832550	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr19:11832550C>T	ENST00000341191.6	-	4	1952	c.1799G>A	c.(1798-1800)aGa>aAa	p.R600K	ZNF823_ENST00000545749.1_Missense_Mutation_p.R418K	NM_001080493.2	NP_001073962.1	P16415	ZN823_HUMAN	zinc finger protein 823	600					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(4)	26						CCTTTTATGTCTATGCAAGGA	0.393000										HNSCC(68;0.2)			7	30					0	0	0.307466	0	0
GIMAP8	155038	broad.mit.edu	37	7	150163958	150163958	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr7:150163958G>A	ENST00000307271.3	+	2	746	c.172G>A	c.(172-174)Gaa>Aaa	p.E58K		NM_175571.2	NP_783161.1	Q8ND71	GIMA8_HUMAN	GTPase, IMAP family member 8	58						endoplasmic reticulum|Golgi apparatus|mitochondrion	GTP binding			breast(3)|central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(26)|ovary(2)|skin(7)|stomach(1)|urinary_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.17)		GGTCCTGAGAGAAAGGAAGGT	0.478000													82	64					0	0	0.870114	0	0
SLCO6A1	133482	broad.mit.edu	37	5	101795412	101795412	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr5:101795412G>A	ENST00000506729.1	-	5	1140	c.969C>T	c.(967-969)gtC>gtT	p.V323V	SLCO6A1_ENST00000514551.1_5'UTR|SLCO6A1_ENST00000379807.3_Silent_p.V323V|SLCO6A1_ENST00000389019.3_Silent_p.V261V|SLCO6A1_ENST00000379810.1_Intron|SLCO6A1_ENST00000513675.1_Intron			Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family, member 6A1	323						integral to membrane|plasma membrane	transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(17)|lung(22)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	60		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		ACCATGCAACGACAGCGGCAA	0.338000													21	57					0	0	0.608945	0	0
NDST4	64579	broad.mit.edu	37	4	115767040	115767040	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr4:115767040G>A	ENST00000264363.2	-	10	2732	c.2054C>T	c.(2053-2055)cCc>cTc	p.P685L		NM_022569.1	NP_072091.1	Q9H3R1	NDST4_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4	685	Heparan sulfate N-sulfotransferase 4.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(43)|ovary(1)|prostate(7)|skin(11)|upper_aerodigestive_tract(1)|urinary_tract(1)	81		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000562)		CTTGGCTTTGGGGACAAGAGA	0.438000													30	39					0	0	0.740014	0	0
IKBKAP	8518	broad.mit.edu	37	9	111663953	111663953	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr9:111663953G>A	ENST00000374647.5	-	17	2170	c.1863C>T	c.(1861-1863)gtC>gtT	p.V621V	IKBKAP_ENST00000537196.1_Silent_p.V272V	NM_003640.3	NP_003631.2	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	621					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			NS(2)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						TCAGACCAAGGACACATTCCT	0.388000													8	22					0	0	0.335167	0	0
SDSL	113675	broad.mit.edu	37	12	113873225	113873225	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr12:113873225C>T	ENST00000403593.4	+	6	797	c.535C>T	c.(535-537)Ctg>Ttg	p.L179L	SDSL_ENST00000345635.4_Silent_p.L179L			Q96GA7	SDSL_HUMAN	serine dehydratase-like	179					cellular amino acid metabolic process		L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|pyridoxal phosphate binding			endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)	15					Pyridoxal Phosphate(DB00114)	TGGGGGTCTCCTGGCCGGGGT	0.662000													12	9					0	0	0.387290	0	0
PHLDB2	90102	broad.mit.edu	37	3	111659439	111659439	+	Missense_Mutation	SNP	G	G	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr3:111659439G>C	ENST00000431670.2	+	8	2755	c.2344G>C	c.(2344-2346)Gag>Cag	p.E782Q	PHLDB2_ENST00000481953.1_Missense_Mutation_p.E739Q|PHLDB2_ENST00000393925.3_Missense_Mutation_p.E782Q|PHLDB2_ENST00000412622.1_Missense_Mutation_p.E739Q|PHLDB2_ENST00000495180.1_Missense_Mutation_p.E368Q|PHLDB2_ENST00000393923.3_Missense_Mutation_p.E766Q	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	782						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						GGCTCAGAGAGAGCAAGATCA	0.353000													6	7					0	0	0.248553	0	0
PLEC	5339	broad.mit.edu	37	8	145001238	145001238	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr8:145001238G>A	ENST00000322810.4	-	29	4432	c.4263C>T	c.(4261-4263)ctC>ctT	p.L1421L	PLEC_ENST00000354589.3_Silent_p.L1284L|PLEC_ENST00000356346.3_Silent_p.L1270L|PLEC_ENST00000436759.2_Silent_p.L1311L|PLEC_ENST00000357649.2_Silent_p.L1288L|PLEC_ENST00000354958.2_Silent_p.L1262L|PLEC_ENST00000527096.1_Silent_p.L1307L|PLEC_ENST00000398774.2_Silent_p.L1252L|PLEC_ENST00000345136.3_Silent_p.L1284L	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	1421	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						TCACCAGCTGGAGTTCATAGT	0.627000													11	17					0	0	0.387290	0	0
OR10R2	343406	broad.mit.edu	37	1	158450467	158450467	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr1:158450467T>C	ENST00000368152.1	+	1	800	c.800T>C	c.(799-801)gTt>gCt	p.V267A	RP11-144L1.4_ENST00000426251.1_RNA|RP11-144L1.4_ENST00000419738.1_RNA	NM_001004472.1	NP_001004472.1	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R, member 2	267					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(26)|pancreas(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	41	all_hematologic(112;0.0378)					CACCTCAGTGTTGTTATTGTT	0.478000													25	20					0	0	0.654019	0	0
S100A7	6278	broad.mit.edu	37	1	153430314	153430314	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr1:153430314C>T	ENST00000368723.3	-	3	384	c.274G>A	c.(274-276)Gga>Aga	p.G92R	S100A7_ENST00000368722.1_Missense_Mutation_p.G92R	NM_002963.3	NP_002954.2	P31151	S10A7_HUMAN	S100 calcium binding protein A7	92					angiogenesis|defense response to Gram-negative bacterium|innate immune response|keratinocyte differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of granulocyte chemotaxis|positive regulation of monocyte chemotaxis|positive regulation of T cell chemotaxis|response to lipopolysaccharide|response to reactive oxygen species|sequestering of metal ion	cytosol|endoplasmic reticulum|extracellular region|focal adhesion|nucleus	calcium ion binding|RAGE receptor binding|zinc ion binding			breast(1)|large_intestine(2)|lung(5)|skin(2)	10	all_lung(78;2.4e-33)|Lung NSC(65;8.13e-32)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGCGCTGCTCCATGGCTCTGC	0.517000													19	51					0	0	0.575678	0	0
CYP11B1	1584	broad.mit.edu	37	8	143956421	143956421	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr8:143956421G>A	ENST00000292427.4	-	8	1382	c.1350C>T	c.(1348-1350)tgC>tgT	p.C450C	CYP11B1_ENST00000517471.1_Intron|CYP11B1_ENST00000377675.3_Silent_p.C521C	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	450					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity			central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	GCCGCCCAAGGCACTGGCGCA	0.682000									Familial Hyperaldosteronism type I				37	57					0	0	0.827153	0	0
GOLGB1	2804	broad.mit.edu	37	3	121417268	121417268	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr3:121417268A>T	ENST00000393667.3	-	13	2212	c.2102T>A	c.(2101-2103)cTc>cAc	p.L701H	GOLGB1_ENST00000340645.5_Missense_Mutation_p.L696H	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	696					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		GTTTAGCTCGAGCTCCAAAAT	0.363000													10	16					0	0	0.387290	0	0
AHNAK	79026	broad.mit.edu	37	11	62293840	62293840	+	Silent	SNP	A	A	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr11:62293840A>T	ENST00000378024.4	-	5	8323	c.8049T>A	c.(8047-8049)atT>atA	p.I2683I	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2683					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				CTGGTCCTTCAATGTTAACAT	0.483000													22	71					0	0	0.592651	0	0
SHANK2	22941	broad.mit.edu	37	11	70319502	70319502	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr11:70319502C>T	ENST00000338508.4	-	33	5024	c.5025G>A	c.(5023-5025)acG>acA	p.T1675T	SHANK2_ENST00000409161.1_Silent_p.T1078T|SHANK2_ENST00000449833.2_Silent_p.T1079T|SHANK2_ENST00000423696.2_Silent_p.T1295T			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1295					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			AGGTGACCGTCGTGCTCCGTG	0.602000													17	18					0	0	0.539581	0	0
SVOP	55530	broad.mit.edu	37	12	109306352	109306352	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr12:109306352C>T	ENST00000299134.5	-	14	1409	c.1410G>A	c.(1408-1410)acG>acA	p.T470T		NM_018711.2	NP_061181.1	Q8N4V2	SVOP_HUMAN	SV2 related protein homolog (rat)	0						cell junction|integral to membrane|synaptic vesicle membrane	ion transmembrane transporter activity			breast(2)|lung(4)	6						ACACCTGCACCGTGCATTCCT	0.627000													83	55					0	0	0.870114	0	0
PLA1A	51365	broad.mit.edu	37	3	119334876	119334876	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr3:119334876C>T	ENST00000273371.4	+	6	754	c.682C>T	c.(682-684)Ccc>Tcc	p.P228S	PLA1A_ENST00000495992.1_Missense_Mutation_p.P212S|PLA1A_ENST00000494440.1_Missense_Mutation_p.P212S|PLA1A_ENST00000488919.1_Missense_Mutation_p.P55S	NM_015900.3	NP_056984.1	Q53H76	PLA1A_HUMAN	phospholipase A1 member A	228					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TATTCGGATTCCCGTTGGACA	0.522000													4	10					0	0	0.184627	0	0
DMBT1	1755	broad.mit.edu	37	10	124399762	124399762	+	Silent	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr10:124399762C>T	ENST00000368909.3	+	52	6868	c.6762C>T	c.(6760-6762)gaC>gaT	p.D2254D	DMBT1_ENST00000344338.3_Silent_p.D2244D|DMBT1_ENST00000368956.2_Silent_p.D1626D|DMBT1_ENST00000359586.6_Silent_p.D974D|DMBT1_ENST00000330163.4_Silent_p.D1626D|DMBT1_ENST00000368955.3_Silent_p.D2244D|DMBT1_ENST00000338354.3_Silent_p.D2254D	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	2254	ZP.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GCAATTTTGACGTGAACATTT	0.463000													25	48					0	0	0.667858	0	0
DSG3	1830	broad.mit.edu	37	18	29054145	29054145	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr18:29054145G>A	ENST00000257189.4	+	15	2246	c.2163G>A	c.(2161-2163)atG>atA	p.M721I		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	721					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			GAATGGAAATGACCACTAAGC	0.493000													20	4					0	0	0.592651	0	0
RAD17	5884	broad.mit.edu	37	5	68667346	68667346	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr5:68667346T>C	ENST00000509734.1	+	3	682	c.4T>C	c.(4-6)Tca>Cca	p.S2P	RAD17_ENST00000354868.5_5'UTR|RAD17_ENST00000305138.4_Intron|RAD17_ENST00000504177.1_Intron|RAD17_ENST00000282891.6_Intron|RAD17_ENST00000354312.3_Intron|RAD17_ENST00000358030.2_Intron|RAD17_ENST00000361732.2_Intron|RAD17_ENST00000345306.6_Intron|RAD17_ENST00000521422.1_Intron|RAD17_ENST00000380774.3_Missense_Mutation_p.S2P			O75943	RAD17_HUMAN	RAD17 homolog (S. pombe)	2					cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding						Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		GTTTATAATGTCAAAAACTTT	0.353000								Other conserved DNA damage response genes					20	18					0	0	0.639603	0	0
IGHE	3497	broad.mit.edu	37	14	106066370	106066370	+	RNA	SNP	T	T	C	rs1134593		TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr14:106066370T>C	ENST00000412518.1	-	0	6				IGHE_ENST00000577108.1_RNA|IGHE_ENST00000576077.1_RNA																							CACAGCTGGATGGAGCCCTGG	0.602000													5	99					0	0	0.248553	0	0
ST18	9705	broad.mit.edu	37	8	53084721	53084721	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr8:53084721G>A	ENST00000276480.7	-	10	1383	c.700C>T	c.(700-702)Cct>Tct	p.P234S		NM_014682.2	NP_055497.1	O60284	ST18_HUMAN	suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein)	234						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(14)|lung(38)|ovary(4)|prostate(2)|skin(11)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	85		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TTTATTTCAGGAACTTCCAAT	0.418000													22	35					0	0	0.608945	0	0
LIG1	3978	broad.mit.edu	37	19	48643347	48643347	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr19:48643347G>A	ENST00000263274.7	-	12	1387	c.968C>T	c.(967-969)tCg>tTg	p.S323L	LIG1_ENST00000536218.1_Missense_Mutation_p.S255L|LIG1_ENST00000427526.2_Missense_Mutation_p.S292L	NM_000234.1	NP_000225.1	P18858	DNLI1_HUMAN	ligase I, DNA, ATP-dependent	323					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			breast(1)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(22)|prostate(2)|skin(1)	44		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	GTCTGGAGGCGACAGGGCCAC	0.632000								Nucleotide excision repair (NER)					10	35					0	0	0.361761	0	0
LLGL2	3993	broad.mit.edu	37	17	73569700	73569700	+	Missense_Mutation	SNP	C	C	G			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr17:73569700C>G	ENST00000392550.3	+	21	2981	c.2864C>G	c.(2863-2865)cCg>cGg	p.P955R	LLGL2_ENST00000167462.5_Missense_Mutation_p.P955R|LLGL2_ENST00000577200.1_Missense_Mutation_p.P955R	NM_001031803.1	NP_001026973.1	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 (Drosophila)	955					cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			NS(1)|breast(3)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	31	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			AAGAAGGCCCCGAGCCGAGCC	0.667000													5	18					0	0	0.278610	0	0
DNAH7	56171	broad.mit.edu	37	2	196729224	196729224	+	Silent	SNP	C	C	T	rs150035002		TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr2:196729224C>T	ENST00000312428.6	-	41	7255	c.7155G>A	c.(7153-7155)agG>agA	p.R2385R		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2385	AAA 4 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.R2385R(1)		NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CCGCACATTTCCTTAAGATCA	0.388000													30	27					0	0	0.729181	0	0
WASH6P	653440	broad.mit.edu	37	X	155255094	155255094	+	RNA	SNP	T	T	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chrX:155255094T>C	ENST00000285718.7	+	0	1399				WASH6P_ENST00000461007.1_RNA																							TGCTCTGACATGGACACAGCC	0.617000													4	7					0	0	0.184627	0	0
BEND4	389206	broad.mit.edu	37	4	42145778	42145778	+	Missense_Mutation	SNP	G	G	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr4:42145778G>C	ENST00000502486.1	-	3	1300	c.721C>G	c.(721-723)Caa>Gaa	p.Q241E	BEND4_ENST00000504360.1_Missense_Mutation_p.Q237E	NM_207406.3	NP_997289.2	Q6ZU67	BEND4_HUMAN	BEN domain containing 4	241										NS(2)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(15)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	26						GCAGAAGTTTGTTGTTTCCTT	0.453000													10	15					0	0	0.361761	0	0
C5orf42	65250	broad.mit.edu	37	5	37196031	37196031	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr5:37196031C>T	ENST00000274258.7	-	21	3970	c.383G>A	c.(382-384)gGa>gAa	p.G128E	C5orf42_ENST00000425232.2_Missense_Mutation_p.G1247E|C5orf42_ENST00000508244.1_Missense_Mutation_p.G1247E			E9PH94	E9PH94_HUMAN	chromosome 5 open reading frame 42	1247										breast(5)|endometrium(3)|kidney(8)|large_intestine(24)|lung(28)|ovary(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	79	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TGCGATACCTCCTTTACAGTA	0.378000													28	30					0	0	0.706142	0	0
LRGUK	136332	broad.mit.edu	37	7	133943151	133943151	+	Missense_Mutation	SNP	C	C	T	rs113393042	byFrequency	TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr7:133943151C>T	ENST00000285928.2	+	19	2410	c.2341C>T	c.(2341-2343)Cgg>Tgg	p.R781W		NM_144648.1	NP_653249.1	Q96M69	LRGUK_HUMAN	leucine-rich repeats and guanylate kinase domain containing	781							ATP binding|kinase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(12)|lung(23)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	49						CGAAGAGACCCGGAAAGGTAT	0.557000													20	22					0	0	0.557998	0	0
BBS10	79738	broad.mit.edu	37	12	76739666	76739666	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr12:76739666G>A	ENST00000393262.3	-	2	2182	c.2099C>T	c.(2098-2100)aCc>aTc	p.T700I		NM_024685.3	NP_078961.3	Q8TAM1	BBS10_HUMAN	Bardet-Biedl syndrome 10	700					cellular protein metabolic process|nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	cilium	ATP binding			endometrium(2)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|skin(1)	19						CATGTCAATGGTTAATATTTT	0.353000									Bardet-Biedl syndrome				19	19					0	0	0.539581	0	0
DDB1	1642	broad.mit.edu	37	11	61090509	61090509	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr11:61090509G>A	ENST00000301764.7	-	8	1376	c.979C>T	c.(979-981)Cgc>Tgc	p.R327C	DDB1_ENST00000450997.2_Intron|DDB1_ENST00000545930.1_5'UTR	NM_001923.4	NP_001914.3	Q16531	DDB1_HUMAN	damage-specific DNA binding protein 1, 127kDa	327	Interaction with CDT1.				cell cycle checkpoint|interspecies interaction between organisms|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	Cul4A-RING ubiquitin ligase complex|Cul4B-RING ubiquitin ligase complex|cytoplasm|nucleoplasm	damaged DNA binding|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	48						TCACCCAGGCGAGACCCGACA	0.438000								Nucleotide excision repair (NER)					16	10					0	0	0.520397	0	0
TBP	6908	broad.mit.edu	37	6	170871052	170871052	+	Silent	SNP	G	G	A	rs112083427		TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr6:170871052G>A	ENST00000392092.2	+	3	507	c.228G>A	c.(226-228)caG>caA	p.Q76Q	TBP_ENST00000230354.6_Silent_p.Q76Q|TBP_ENST00000540980.1_Silent_p.Q56Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	76	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q76Q(4)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcaacagcagcagcagcagc	0.572000													5	28					0	0	0.184627	0	0
KRT20	54474	broad.mit.edu	37	17	39041328	39041328	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr17:39041328C>T	ENST00000167588.3	-	1	151	c.110G>A	c.(109-111)gGg>gAg	p.G37E		NM_019010.2	NP_061883.1	P35900	K1C20_HUMAN	keratin 20	37	Head.				apoptosis|intermediate filament organization	Golgi apparatus|intermediate filament	protein binding|structural constituent of cytoskeleton			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|skin(1)	14		Breast(137;0.000301)|Ovarian(249;0.15)				TCCAGCACCCCCATAAACGCT	0.612000													34	8					0	0	0.812448	0	0
PWP1	11137	broad.mit.edu	37	12	108090341	108090341	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr12:108090341C>T	ENST00000412830.3	+	6	761	c.593C>T	c.(592-594)cCt>cTt	p.P198L	PWP1_ENST00000541166.1_Missense_Mutation_p.P136L	NM_007062.1	NP_008993.1	Q13610	PWP1_HUMAN	PWP1 homolog (S. cerevisiae)	198					transcription, DNA-dependent	nucleus				breast(3)|endometrium(4)|kidney(1)|large_intestine(8)|lung(6)|urinary_tract(1)	23						AATTTTGATCCTAGCCCAGAT	0.333000													18	32					0	0	0.557998	0	0
NT5C1B	93034	broad.mit.edu	37	2	18766203	18766203	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr2:18766203G>A	ENST00000304081.4	-	4	400	c.300C>T	c.(298-300)tcC>tcT	p.S100S	NT5C1B_ENST00000600945.1_Silent_p.S160S|NT5C1B-RDH14_ENST00000532967.1_Silent_p.S160S|NT5C1B_ENST00000359846.2_Silent_p.S160S	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				GCAGGCTTGGGGAGGTGGATG	0.701000													4	6					0	0	0.150653	0	0
DSCAM	1826	broad.mit.edu	37	21	42080524	42080524	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr21:42080524G>A	ENST00000400454.1	-	2	694	c.217C>T	c.(217-219)Cgc>Tgc	p.R73C		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	73	Ig-like C2-type 1.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				TGGACGTGGCGGATCCCGGGG	0.552000													15	60					0	0	0.457914	0	0
OR4K5	79317	broad.mit.edu	37	14	20389642	20389642	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr14:20389642G>A	ENST00000315915.4	+	1	902	c.877G>A	c.(877-879)Gat>Aat	p.D293N		NM_001005483.1	NP_001005483.1	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K, member 5	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|liver(1)|lung(27)|ovary(1)|skin(3)|stomach(1)|urinary_tract(1)	47	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		AAGGAATAGGGATATGAAGGC	0.398000													42	103					0	0	0.847076	0	0
SIRPB2	284759	broad.mit.edu	37	20	1457880	1457880	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr20:1457880T>C	ENST00000537284.1	-	5	884	c.548A>G	c.(547-549)aAc>aGc	p.N183S	SIRPB2_ENST00000381630.1_3'UTR|SIRPB2_ENST00000359801.3_Intron|SIRPB2_ENST00000444444.1_Intron			Q5JXA9	SIRB2_HUMAN	signal-regulatory protein beta 2	0	Ig-like V-type 2.					integral to membrane				endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						TGGTGGCAGGTTAGCCCCAGG	0.537000													17	23					0	0	0.500413	0	0
NPAP1	23742	broad.mit.edu	37	15	24922213	24922213	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr15:24922213C>T	ENST00000329468.2	+	1	1673	c.1199C>T	c.(1198-1200)tCt>tTt	p.S400F		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CCTGCCCCTTCTTTCTCCCAA	0.532000													4	23					0	0	0.184627	0	0
ANKRD6	22881	broad.mit.edu	37	6	90333234	90333234	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr6:90333234G>A	ENST00000369408.5	+	10	1247	c.898G>A	c.(898-900)Gat>Aat	p.D300N	ANKRD6_ENST00000522441.1_Missense_Mutation_p.D335N|ANKRD6_ENST00000339746.4_Missense_Mutation_p.D335N|ANKRD6_ENST00000447838.2_Missense_Mutation_p.D335N|LYRM2_ENST00000520441.1_Intron|ANKRD6_ENST00000520793.1_Missense_Mutation_p.D276N	NM_001242813.1	NP_001229742.1	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	335							protein binding			NS(1)|endometrium(3)|large_intestine(7)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|stomach(2)	21		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		CAGAGCAAAGGATGACAGGAG	0.597000													7	6					0	0	0.278610	0	0
FBN2	2201	broad.mit.edu	37	5	127700391	127700391	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr5:127700391T>C	ENST00000508053.1	-	24	3304	c.2330A>G	c.(2329-2331)gAt>gGt	p.D777G	FBN2_ENST00000262464.4_Missense_Mutation_p.D777G|FBN2_ENST00000508989.1_Missense_Mutation_p.D744G			P35556	FBN2_HUMAN	fibrillin 2	777	EGF-like 11; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGCACATATATCAGGATCCAA	0.358000													9	22					0	0	0.307466	0	0
ANKH	56172	broad.mit.edu	37	5	14758613	14758613	+	Silent	SNP	G	G	A			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr5:14758613G>A	ENST00000284268.6	-	3	738	c.408C>T	c.(406-408)gcC>gcT	p.A136A		NM_054027.4	NP_473368.1	Q9HCJ1	ANKH_HUMAN	ANKH inorganic pyrophosphate transport regulator	136					locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(13)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						AAGGAAAGGCGGCGAGGTACA	0.418000													9	20					0	0	0.335167	0	0
TRIM15	89870	broad.mit.edu	37	6	30139833	30139833	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr6:30139833delG	ENST00000376694.4	+	7	1574	c.1105delG	c.(1105-1107)ggfs	p.G369fs	TRIM15_ENST00000376688.1_Intron	NM_033229.2	NP_150232.2	Q9C019	TRI15_HUMAN	tripartite motif containing 15	369	B30.2/SPRY.				mesodermal cell fate determination	intracellular	zinc ion binding			large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(1)	14						GGGGGTGGCCGGGGAGGGGGT	0.731													3	5	---	---	---	---					
POM121	9883	broad.mit.edu	37	7	72413723	72413724	+	In_Frame_Ins	INS	-	-	CTC	rs67569765	byFrequency	TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr7:72413723_72413724insCTC	ENST00000395270.1	+	14	3437_3438	c.2396_2397insCTC	c.(2395-2397)ttt>tCTCtt	p.799_799F>SL	POM121_ENST00000434423.2_In_Frame_Ins_p.1064_1064F>SL|POM121_ENST00000358357.3_In_Frame_Ins_p.799_799F>SL|POM121_ENST00000446813.1_In_Frame_Ins_p.799_799F>SL|POM121_ENST00000257622.4_In_Frame_Ins_p.799_799F>SL	NM_001257190.1	NP_001244119.1	Q96HA1	P121A_HUMAN	POM121 transmembrane nucleoporin	1064	Pore side (Potential).|Thr-rich.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|breast(1)|endometrium(9)|kidney(4)|large_intestine(6)|lung(12)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Lung NSC(55;0.163)				ACTGCTGTCTTCTTCGGTGCAG	0.663													7	86	---	---	---	---					
ZNF395	55893	broad.mit.edu	37	8	28209226	28209228	+	In_Frame_Del	DEL	GCA	GCA	-	rs142343457	byFrequency	TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr8:28209226_28209228delGCA	ENST00000344423.5	-	7	1148_1150	c.1017_1019delTGC	c.(1015-1020)gcc>gc	p.AA339del	ZNF395_ENST00000523095.1_In_Frame_Del_p.AA339del|ZNF395_ENST00000523202.1_In_Frame_Del_p.AA339del	NM_018660.2	NP_061130.1	Q9H8N7	ZN395_HUMAN	zinc finger protein 395	339					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			cervix(1)|endometrium(1)|kidney(5)|large_intestine(6)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24		Ovarian(32;2.06e-05)		KIRC - Kidney renal clear cell carcinoma(542;0.102)|Kidney(114;0.123)|Colorectal(74;0.142)		GGTGCCTgcggcagcagcagcag	0.606													7	126	---	---	---	---					
TM9SF3	56889	broad.mit.edu	37	10	98287894	98287895	+	Frame_Shift_Ins	INS	-	-	AT			TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr10:98287894_98287895insAT	ENST00000371142.4	-	12	1650_1651	c.1434_1435insAT	c.(1432-1437)taatgtfs	p.C479fs		NM_020123.3	NP_064508.3	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3	479						integral to membrane	binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(2)|prostate(1)	15		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		CCATAGACATAATAGATCTTAT	0.376													14	30	---	---	---	---					
RP11-67H24.2	0	broad.mit.edu	37	16	32823636	32823637	+	RNA	INS	-	-	C	rs112857933		TCGA-DA-A1I2-06A-21D-A19A-08	TCGA-DA-A1I2-10A-01D-A19A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	d432e99a-67fb-4609-b90f-99438eee7cae	33941005-40a5-45da-a497-bd3fcfbbec30	g.chr16:32823636_32823637insC	ENST00000569859.1	+	0	373																											TTGCTGGAGTGGATGTGACAGG	0.495													5	10	---	---	---	---					
