Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CLSPN	63967	broad.mit.edu	37	1	36230223	36230223	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:36230223G>A	ENST00000251195.5	-	3	322	c.226C>T	c.(226-228)Cca>Tca	p.P76S	CLSPN_ENST00000520551.1_Missense_Mutation_p.P76S|CLSPN_ENST00000318121.3_Missense_Mutation_p.P76S|CLSPN_ENST00000373220.3_Missense_Mutation_p.P76S			Q9HAW4	CLSPN_HUMAN	claspin	76					activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			NS(2)|breast(3)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	56		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				GTTTTCTCTGGAGAGGCATTT	0.373000													14	44					0	0	0.000566183	0	0
IZUMO2	126123	broad.mit.edu	37	19	50657946	50657946	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:50657946C>T	ENST00000293405.3	-	6	534	c.534G>A	c.(532-534)atG>atA	p.M178I		NM_152358.2	NP_689571.2	Q6UXV1	IZUM2_HUMAN	IZUMO family member 2	178						integral to membrane				cervix(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(1)	7						ATTTGCTGTCCATCTGGTACT	0.612000													5	64					0	0	0.000602214	0	0
ATP8B4	79895	broad.mit.edu	37	15	50215620	50215620	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:50215620G>A	ENST00000284509.6	-	17	1855	c.1714C>T	c.(1714-1716)Cct>Tct	p.P572S	ATP8B4_ENST00000559829.1_Missense_Mutation_p.P572S	NM_024837.2	NP_079113.2	Q8TF62	AT8B4_HUMAN	ATPase, class I, type 8B, member 4	572					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(6)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|urinary_tract(1)	73		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		TCATTGGAAGGATGAAGTTTT	0.408000													11	29					0	0	0.00136819	0	0
APOB	338	broad.mit.edu	37	2	21225135	21225135	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:21225135C>T	ENST00000233242.1	-	29	13286	c.13159G>A	c.(13159-13161)Gaa>Aaa	p.E4387K		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4387					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCAAAATATTCTTCACGAAGG	0.358000													206	507					0	0	0.000781405	0	0
LRRC18	474354	broad.mit.edu	37	10	50122162	50122162	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:50122162G>A	ENST00000374160.3	-	1	115	c.39C>T	c.(37-39)atC>atT	p.I13I	WDFY4_ENST00000413659.2_Intron|LRRC18_ENST00000298124.3_Silent_p.I13I|WDFY4_ENST00000325239.5_Intron|RP11-523O18.7_ENST00000430438.1_RNA	NM_001006939.3	NP_001006940.3	Q8N456	LRC18_HUMAN	leucine rich repeat containing 18	13						cytoplasm				NS(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	18						CCTTGAGGGTGATCTTCTTGC	0.443000													21	36					0	0	0.00278032	0	0
ACAD10	80724	broad.mit.edu	37	12	112182825	112182825	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:112182825C>T	ENST00000455480.2	+	14	2363	c.2186C>T	c.(2185-2187)tCc>tTc	p.S729F	ACAD10_ENST00000313698.4_Missense_Mutation_p.S698F|ACAD10_ENST00000549590.1_Missense_Mutation_p.S698F|ACAD10_ENST00000413681.3_3'UTR|ACAD10_ENST00000392636.2_Missense_Mutation_p.S300F	NM_001136538.1	NP_001130010.1	Q6JQN1	ACD10_HUMAN	acyl-CoA dehydrogenase family, member 10	698							acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|hydrolase activity|transferase activity, transferring phosphorus-containing groups	p.S698F(1)		NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(17)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(5)	47						TGGAGCCCCTCCCCACTGATC	0.602000													13	30					0	0	0.00244969	0	0
PIK3C2B	5287	broad.mit.edu	37	1	204401437	204401437	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:204401437C>T	ENST00000367187.3	-	28	4602	c.4046G>A	c.(4045-4047)cGg>cAg	p.R1349Q	PIK3C2B_ENST00000424712.2_Missense_Mutation_p.R1321Q|RP11-739N20.2_ENST00000443515.1_RNA	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	1349					cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GAGGGTCAGCCGGTCATCTGA	0.527000													27	93					0	0	0.00106085	0	0
AOAH	313	broad.mit.edu	37	7	36616204	36616204	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:36616204C>T	ENST00000431169.1	-	13	1297	c.997G>A	c.(997-999)Gac>Aac	p.D333N	AOAH_ENST00000538464.1_Missense_Mutation_p.D55N|AOAH_ENST00000535891.1_Missense_Mutation_p.D301N|AOAH_ENST00000258749.5_Missense_Mutation_p.D333N	NM_001177506.1	NP_001170977.1	P28039	AOAH_HUMAN	acyloxyacyl hydrolase (neutrophil)	333					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(21)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	41						TTCTGGTAGTCCCTGTGATTA	0.308000													32	161					0	0	0.00128727	0	0
USP6	9098	broad.mit.edu	37	17	5048150	5048150	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:5048150G>A	ENST00000574788.1	+	26	4214	c.1984G>A	c.(1984-1986)Gct>Act	p.A662T	USP6_ENST00000332776.4_Missense_Mutation_p.A662T|USP6_ENST00000304328.5_Missense_Mutation_p.A345T|USP6_ENST00000250066.6_Missense_Mutation_p.A662T			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	662					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						CTGGGAAGTAGCTGCAGAGGT	0.408000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								17	64					0	0	0.00121646	0	0
ATP10D	57205	broad.mit.edu	37	4	47514588	47514588	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:47514588C>T	ENST00000273859.3	+	2	300	c.31C>T	c.(31-33)Cac>Tac	p.H11Y	ATP10D_ENST00000504445.1_Missense_Mutation_p.H11Y	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	11					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						GGCCAGATATCACTGGCGACG	0.522000													29	53					0	0	0.00283554	0	0
NLGN4X	57502	broad.mit.edu	37	X	6069279	6069279	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:6069279G>A	ENST00000381095.3	-	2	856	c.229C>T	c.(229-231)Ccc>Tcc	p.P77S	NLGN4X_ENST00000469740.1_5'UTR|NLGN4X_ENST00000381092.1_Missense_Mutation_p.P77S|NLGN4X_ENST00000275857.6_Missense_Mutation_p.P77S|NLGN4X_ENST00000381093.2_Missense_Mutation_p.P77S|NLGN4X_ENST00000538097.1_Missense_Mutation_p.P77S	NM_181332.1	NP_851849.1	Q8N0W4	NLGNX_HUMAN	neuroligin 4, X-linked	77					brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			breast(1)|cervix(2)|endometrium(4)|large_intestine(21)|lung(39)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	81						GAGGCATAGGGGACCCCTAAG	0.542000													18	45					0	0	0.00074312	0	0
CENPT	80152	broad.mit.edu	37	16	67865769	67865769	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:67865769G>A	ENST00000562787.1	-	8	959	c.411C>T	c.(409-411)ctC>ctT	p.L137L	CENPT_ENST00000445712.2_Silent_p.L34L|CENPT_ENST00000564817.1_Silent_p.L137L|CENPT_ENST00000562947.1_5'UTR|CENPT_ENST00000440851.2_Silent_p.L137L|CENPT_ENST00000219172.3_Silent_p.L137L	NM_025082.3	NP_079358.3	Q96BT3	CENPT_HUMAN	centromere protein T	137					mitotic prometaphase	condensed chromosome kinetochore|cytosol|nucleus	DNA binding			NS(1)|breast(2)|lung(6)|urinary_tract(1)	10		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00429)|Epithelial(162;0.019)|all cancers(182;0.124)		TGGGGGGCTCGAGCTCAGGAA	0.577000													17	22					0	0	0.00121646	0	0
ECM1	1893	broad.mit.edu	37	1	150484121	150484121	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:150484121C>T	ENST00000369047.4	+	7	1022	c.897C>T	c.(895-897)ttC>ttT	p.F299F	ECM1_ENST00000369049.4_Silent_p.F326F|ECM1_ENST00000346569.6_Intron|ECM1_ENST00000470432.1_3'UTR	NM_004425.3	NP_004416.2	Q16610	ECM1_HUMAN	extracellular matrix protein 1	299	2 X approximate repeats.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(7)|ovary(2)|prostate(3)|urinary_tract(1)	22	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			AGCTGCCTTTCCCTCCTGGGG	0.597000													13	42					0	0	0.00185496	0	0
SIGLECL1	284369	broad.mit.edu	37	19	51771841	51771841	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:51771841G>A	ENST00000316401.7	+	6	965	c.584G>A	c.(583-585)cGa>cAa	p.R195Q	CTD-3187F8.2_ENST00000597569.1_RNA|SIGLECL1_ENST00000597824.1_Missense_Mutation_p.R101Q|SIGLECL1_ENST00000593968.1_3'UTR	NM_173635.1	NP_775906.1			SIGLEC family like 1																		CAAGATAAACGAGCCAGCTAA	0.418000													7	36					0	0	0.000157383	0	0
NLRP4	147945	broad.mit.edu	37	19	56369333	56369333	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:56369333G>A	ENST00000301295.6	+	3	996	c.574G>A	c.(574-576)Gaa>Aaa	p.E192K	NLRP4_ENST00000346986.5_Missense_Mutation_p.E192K|NLRP4_ENST00000587891.1_Missense_Mutation_p.E117K	NM_134444.4	NP_604393.2	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	192	NACHT.						ATP binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|lung(3)|ovary(6)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(8)	42		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		CTGCTGCAGAGAACTGAGGGA	0.507000													34	80					0	0	0.00058488	0	0
MMP3	4314	broad.mit.edu	37	11	102710983	102710983	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:102710983C>T	ENST00000299855.5	-	6	1047	c.790_splice	c.e6-1	p.G264_splice		NM_002422.3	NP_002413.1	P08254	MMP3_HUMAN	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	264					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			endometrium(2)|kidney(3)|large_intestine(3)|liver(1)|lung(7)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	22		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.0142)	Marimastat(DB00786)|Simvastatin(DB00641)	AGGGGGAGGTCCTAAAGGGAA	0.483000													8	29					0	0	0.000157383	0	0
ERCC6L	54821	broad.mit.edu	37	X	71427199	71427199	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:71427199C>T	ENST00000373657.1	-	3	1651	c.1049G>A	c.(1048-1050)cGa>cAa	p.R350Q	PIN4_ENST00000423432.2_Intron|ERCC6L_ENST00000334463.3_Missense_Mutation_p.R473Q			Q2NKX8	ERC6L_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6-like	473					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol	ATP binding|DNA binding|helicase activity|protein binding			breast(2)|cervix(1)|endometrium(9)|kidney(4)|large_intestine(9)|lung(9)|ovary(3)|skin(1)	38	Renal(35;0.156)					TCCCTCATCTCGCAGCCTCTT	0.398000													12	55					0	0	0.00244969	0	0
P2RX7	5027	broad.mit.edu	37	12	121603181	121603181	+	Silent	SNP	C	C	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:121603181C>G	ENST00000328963.5	+	5	499	c.45C>G	c.(43-45)gcC>gcG	p.A15A	P2RX7_ENST00000535250.1_Silent_p.A95A|P2RX7_ENST00000443520.3_3'UTR|P2RX7_ENST00000377162.2_Silent_p.A185A|P2RX7_ENST00000546057.1_Silent_p.A185A|P2RX7_ENST00000541446.1_5'UTR			A8K2Z0	A8K2Z0_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 7	185						integral to membrane	ATP binding|ion channel activity|receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|stomach(1)	19	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					TGAACAGTGCCGAAAACTTCA	0.552000													40	228					0	0	0.00195071	0	0
C9orf89	84270	broad.mit.edu	37	9	95872948	95872948	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:95872948C>T	ENST00000375464.2	+	3	377	c.249C>T	c.(247-249)gcC>gcT	p.A83A	C9orf89_ENST00000488630.1_3'UTR	NM_032310.3	NP_115686.3	Q96LW7	BINCA_HUMAN	chromosome 9 open reading frame 89	83	CARD.				negative regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|nucleus	CARD domain binding			endometrium(1)|kidney(1)|lung(3)|ovary(1)|skin(1)	7						TCTACCGAGCCCTGTATATCC	0.647000													24	37					0	0	0.00047179	0	0
OR52D1	390066	broad.mit.edu	37	11	5510608	5510608	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:5510608C>T	ENST00000322641.5	+	1	694	c.672C>T	c.(670-672)atC>atT	p.I224I	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|HBG2_ENST00000380259.2_Intron|AC104389.28_ENST00000415970.1_RNA	NM_001005163.2	NP_001005163.1	Q9H346	O52D1_HUMAN	olfactory receptor, family 52, subfamily D, member 1	224					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(8)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	22		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;3.46e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ATGGCTTTATCCTCCATGCAG	0.488000													26	138					0	0	0.00127121	0	0
OR4S2	219431	broad.mit.edu	37	11	55418857	55418857	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:55418857C>T	ENST00000312422.2	+	1	478	c.478C>T	c.(478-480)Ctg>Ttg	p.L160L		NM_001004059.2	NP_001004059.2	Q8NH73	OR4S2_HUMAN	olfactory receptor, family 4, subfamily S, member 2	160					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(28)|ovary(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		all_epithelial(135;0.0748)				CCAAGTGGCTCTGGTAGTCCA	0.433000													63	37					0	0	0.000781405	0	0
DOCK3	1795	broad.mit.edu	37	3	51266179	51266179	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:51266179C>T	ENST00000266037.9	+	18	1758	c.1735C>T	c.(1735-1737)Cct>Tct	p.P579S		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	579	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CCCTAATATTCCTTCTAGCCT	0.478000													15	46					0	0	0.00244969	0	0
PRKDC	5591	broad.mit.edu	37	8	48842431	48842431	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:48842431C>T	ENST00000314191.2	-	18	2090	c.2034G>A	c.(2032-2034)aaG>aaA	p.K678K	PRKDC_ENST00000338368.3_Silent_p.K678K|PRKDC_ENST00000523565.1_5'UTR	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	678					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				ATTTTATTTTCTTGGCATTTC	0.318000								Non-homologous end-joining					10	29					0	0	0.000978159	0	0
SCAMP5	192683	broad.mit.edu	37	15	75310792	75310792	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:75310792G>A	ENST00000361900.6	+	7	636	c.429G>A	c.(427-429)acG>acA	p.T143T	SCAMP5_ENST00000568081.1_Silent_p.T76T|SCAMP5_ENST00000562212.1_Silent_p.T151T|SCAMP5_ENST00000545456.1_Silent_p.T72T|SCAMP5_ENST00000425597.3_Silent_p.T143T	NM_001178111.1	NP_001171582.1	Q8TAC9	SCAM5_HUMAN	secretory carrier membrane protein 5	143					exocytosis|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|positive regulation of cytokine secretion|protein transport|response to endoplasmic reticulum stress	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane|trans-Golgi network membrane	protein binding			large_intestine(1)|lung(1)|ovary(1)|urinary_tract(2)	5						TCTTCGGAACGAACATTGGCT	0.592000													54	127					0	0	0.000781405	0	0
NPHS1	4868	broad.mit.edu	37	19	36321826	36321826	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:36321826G>A	ENST00000378910.5	-	28	3513	c.3514C>T	c.(3514-3516)Cct>Tct	p.P1172S	NPHS1_ENST00000353632.6_Missense_Mutation_p.P1132S	NM_004646.3	NP_004637.1	O60500	NPHN_HUMAN	nephrosis 1, congenital, Finnish type (nephrin)	1172	Binds to NPHS2.				cell adhesion|excretion|muscle organ development	integral to plasma membrane		p.P1172S(1)		NS(2)|breast(1)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(16)|liver(1)|lung(26)|ovary(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	74	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AAGTGCCCAGGGAAGGCCATA	0.562000													15	51					0	0	0.00244969	0	0
CAMK1G	57172	broad.mit.edu	37	1	209785202	209785202	+	Silent	SNP	G	G	A	rs147599953	byFrequency	TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:209785202G>A	ENST00000009105.1	+	11	1226	c.981G>A	c.(979-981)ccG>ccA	p.P327P	CAMK1G_ENST00000361322.2_Silent_p.P327P|CAMK1G_ENST00000494990.1_3'UTR			Q96NX5	KCC1G_HUMAN	calcium/calmodulin-dependent protein kinase IG	327						Golgi membrane|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|central_nervous_system(1)|large_intestine(8)|lung(8)|stomach(1)	20				OV - Ovarian serous cystadenocarcinoma(81;0.0475)		TGCACAGCCCGGGCGTCCGCC	0.597000													26	89					0	0	0.000586117	0	0
C9orf89	84270	broad.mit.edu	37	9	95872947	95872947	+	Missense_Mutation	SNP	C	C	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:95872947C>G	ENST00000375464.2	+	3	376	c.248C>G	c.(247-249)gCc>gGc	p.A83G	C9orf89_ENST00000488630.1_3'UTR	NM_032310.3	NP_115686.3	Q96LW7	BINCA_HUMAN	chromosome 9 open reading frame 89	83	CARD.				negative regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|nucleus	CARD domain binding			endometrium(1)|kidney(1)|lung(3)|ovary(1)|skin(1)	7						TTCTACCGAGCCCTGTATATC	0.647000													23	36					0	0	0.00278032	0	0
NELL2	4753	broad.mit.edu	37	12	44913944	44913944	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:44913944C>T	ENST00000429094.2	-	19	2748	c.2244G>A	c.(2242-2244)gaG>gaA	p.E748E	NELL2_ENST00000549027.1_Silent_p.E747E|NELL2_ENST00000395487.2_Silent_p.E747E|NELL2_ENST00000437801.2_Silent_p.E798E|NELL2_ENST00000551601.1_Silent_p.E700E|NELL2_ENST00000333837.4_Silent_p.E771E|NELL2_ENST00000452445.2_Silent_p.E748E	NM_001145108.1	NP_001138580.1	Q99435	NELL2_HUMAN	NEL-like 2 (chicken)	748	VWFC 4.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(16)|lung(30)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	65	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		AGCACTCATTCTCTGGGAGAA	0.542000													10	9					0	0	0.000442599	0	0
TRHR	7201	broad.mit.edu	37	8	110131314	110131314	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:110131314C>T	ENST00000518632.1	+	3	1178	c.827C>T	c.(826-828)gCc>gTc	p.A276V	TRHR_ENST00000311762.2_Missense_Mutation_p.A276V			P34981	TRFR_HUMAN	thyrotropin-releasing hormone receptor	276						integral to plasma membrane	thyrotropin-releasing hormone receptor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(12)|prostate(4)|skin(4)|urinary_tract(1)	37			OV - Ovarian serous cystadenocarcinoma(57;2.3e-11)			ATTCTGTTTGCCCTTTTATGG	0.403000													80	175					0	0	0.000781405	0	0
VWF	7450	broad.mit.edu	37	12	6103617	6103617	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:6103617G>A	ENST00000261405.5	-	36	6474	c.6220C>T	c.(6220-6222)Ccc>Tcc	p.P2074S		NM_000552.3	NP_000543.2	P04275	VWF_HUMAN	von Willebrand factor	2074	VWFD 4.				blood coagulation, intrinsic pathway|cell-substrate adhesion|platelet activation|platelet degranulation|protein homooligomerization	endoplasmic reticulum|platelet alpha granule lumen|proteinaceous extracellular matrix|Weibel-Palade body	chaperone binding|collagen binding|glycoprotein binding|immunoglobulin binding|integrin binding|protease binding|protein homodimerization activity|protein N-terminus binding	p.P2074S(1)		NS(1)|breast(6)|central_nervous_system(5)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(41)|ovary(7)|pancreas(2)|prostate(6)|skin(15)|stomach(1)|upper_aerodigestive_tract(5)	129					Antihemophilic Factor(DB00025)	AAAGTCTTGGGGCTGAGCTGC	0.428000													39	112					0	0	0.00222228	0	0
LTBP1	4052	broad.mit.edu	37	2	33525539	33525539	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:33525539G>A	ENST00000404816.2	+	21	3610	c.3257G>A	c.(3256-3258)gGg>gAg	p.G1086E	LTBP1_ENST00000272273.5_Missense_Mutation_p.G26E|LTBP1_ENST00000404525.1_Missense_Mutation_p.G707E|LTBP1_ENST00000498013.1_3'UTR|LTBP1_ENST00000402934.1_Missense_Mutation_p.G707E|LTBP1_ENST00000354476.3_Missense_Mutation_p.G1087E|LTBP1_ENST00000418533.2_Missense_Mutation_p.G760E|LTBP1_ENST00000390003.4_Missense_Mutation_p.G761E|LTBP1_ENST00000407925.1_Missense_Mutation_p.G760E			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	1086	EGF-like 9; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				TGTCAGCAAGGGAATCTATGT	0.488000													19	44					0	0	0.00278032	0	0
EPB41L2	2037	broad.mit.edu	37	6	131276354	131276354	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:131276354G>A	ENST00000337057.3	-	3	777	c.596C>T	c.(595-597)aCc>aTc	p.T199I	EPB41L2_ENST00000530148.1_Intron|EPB41L2_ENST00000525271.1_Missense_Mutation_p.T199I|EPB41L2_ENST00000529208.1_Missense_Mutation_p.T199I|EPB41L2_ENST00000528282.1_Missense_Mutation_p.T199I|EPB41L2_ENST00000392427.3_Missense_Mutation_p.T199I|EPB41L2_ENST00000530481.1_Missense_Mutation_p.T199I|EPB41L2_ENST00000445890.2_Missense_Mutation_p.T199I|EPB41L2_ENST00000368128.2_Missense_Mutation_p.T199I|EPB41L2_ENST00000527411.1_Missense_Mutation_p.T199I|EPB41L2_ENST00000527659.1_Missense_Mutation_p.T199I|EPB41L2_ENST00000525193.1_Missense_Mutation_p.T199I	NM_001431.3	NP_001422.1	O43491	E41L2_HUMAN	erythrocyte membrane protein band 4.1-like 2	199					cortical actin cytoskeleton organization	extrinsic to membrane|plasma membrane|spectrin	actin binding|structural molecule activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(23)|prostate(1)|skin(2)	44	Breast(56;0.0639)			OV - Ovarian serous cystadenocarcinoma(155;0.0271)|GBM - Glioblastoma multiforme(226;0.0355)		CAGCTCATTGGTCTGCACTTC	0.433000													43	112					0	0	0.000781405	0	0
LAMA2	3908	broad.mit.edu	37	6	129837450	129837450	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:129837450G>A	ENST00000421865.2	+	65	9376	c.9327G>A	c.(9325-9327)ctG>ctA	p.L3109L		NM_000426.3|NM_001079823.1	NP_000417.2|NP_001073291.1	P24043	LAMA2_HUMAN	laminin, alpha 2	3109	Laminin G-like 5.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			NS(2)|biliary_tract(2)|breast(10)|central_nervous_system(1)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(35)|lung(84)|ovary(10)|prostate(4)|skin(9)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(2)	194				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CCAAGGCCCTGGAACTGAGGG	0.463000													20	39					0	0	0.00121646	0	0
TUBA4A	7277	broad.mit.edu	37	2	220115512	220115512	+	Silent	SNP	T	T	C	rs141922502	byFrequency	TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:220115512T>C	ENST00000392088.2	-	4	1419	c.864A>G	c.(862-864)gtA>gtG	p.V288V	TUBA4A_ENST00000248437.4_Silent_p.V303V|TUBA4A_ENST00000498660.1_5'UTR	NM_001278552.1	NP_001265481.1	P68366	TBA4A_HUMAN	tubulin, alpha 4a	303					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|platelet activation|platelet degranulation|protein polymerization	cytosol|extracellular region|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	20		Renal(207;0.0474)		Epithelial(149;1.16e-06)|all cancers(144;0.000191)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GATCACACTTTACCATCTGGT	0.567000													28	59					0	0	0.00178596	0	0
COL5A2	1290	broad.mit.edu	37	2	189932972	189932972	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:189932972G>A	ENST00000374866.3	-	20	1556	c.1282C>T	c.(1282-1284)Cct>Tct	p.P428S		NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2	428					axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			TTGGCACCAGGAGTACCATCA	0.408000													44	95					0	0	0.000781405	0	0
CCDC37	348807	broad.mit.edu	37	3	126138654	126138654	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:126138654G>A	ENST00000393425.1	+	9	1008	c.909G>A	c.(907-909)ggG>ggA	p.G303G	CCDC37_ENST00000352312.1_Silent_p.G302G|CCDC37_ENST00000505024.1_Silent_p.G303G			Q494V2	CCD37_HUMAN	coiled-coil domain containing 37	302										NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|skin(3)	23				GBM - Glioblastoma multiforme(114;0.166)		CCACACCAGGGGACAAAGGTA	0.547000													4	36					0	0	0.000602214	0	0
DOCK9	23348	broad.mit.edu	37	13	99538816	99538816	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr13:99538816G>A	ENST00000376460.1	-	19	2186	c.2106C>T	c.(2104-2106)caC>caT	p.H702H	DOCK9_ENST00000448493.2_Silent_p.H714H|DOCK9_ENST00000442173.1_Silent_p.H702H|DOCK9_ENST00000339416.2_Silent_p.H703H	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	703	DHR-1.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					TTTGGTGATGGTGTAAAACTG	0.403000													8	32					0	0	0.000442599	0	0
KMT2A	4297	broad.mit.edu	37	11	118390453	118390453	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:118390453C>T	ENST00000534358.1	+	32	11290	c.11267C>T	c.(11266-11268)gCc>gTc	p.A3756V	RP11-770J1.3_ENST00000528578.1_RNA|KMT2A_ENST00000389506.5_Missense_Mutation_p.A3753V|RP11-770J1.3_ENST00000525992.2_RNA|RP11-770J1.3_ENST00000554407.1_RNA|KMT2A_ENST00000354520.4_Missense_Mutation_p.A3715V|RP11-770J1.3_ENST00000532597.1_RNA|RP11-770J1.3_ENST00000556583.1_RNA	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		CCAGAGGAGGCCAATGAACCC	0.517000													22	52					0	0	0.00278032	0	0
DNAH7	56171	broad.mit.edu	37	2	196741347	196741347	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:196741347G>A	ENST00000312428.6	-	37	6138	c.6038C>T	c.(6037-6039)gCt>gTt	p.A2013V		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2013	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CTGAGTTTGAGCTGCTGTAGT	0.323000													19	44					0	0	0.00152264	0	0
KCNK17	89822	broad.mit.edu	37	6	39272353	39272353	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:39272353T>C	ENST00000453413.2	-	3	571	c.431A>G	c.(430-432)aAc>aGc	p.N144S	KCNK17_ENST00000373231.4_Missense_Mutation_p.N144S	NM_001135111.1	NP_001128583.1	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	144						integral to membrane	potassium channel activity|voltage-gated ion channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(2)	14						CACCACGAGGTTGAGTGGGAT	0.632000													41	92					0	0	0.000680045	0	0
OR4N5	390437	broad.mit.edu	37	14	20612775	20612775	+	Missense_Mutation	SNP	T	T	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr14:20612775T>G	ENST00000333629.1	+	1	881	c.881T>G	c.(880-882)gTg>gGg	p.V294G		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	294					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		AACCAGGAGGTGAAAGCTTCC	0.403000													22	36					0	0	0.000586117	0	0
HERC4	26091	broad.mit.edu	37	10	69752044	69752044	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:69752044G>A	ENST00000395198.3	-	11	1430	c.1183C>T	c.(1183-1185)Ccg>Tcg	p.P395S	HERC4_ENST00000373700.4_Missense_Mutation_p.P395S|HERC4_ENST00000412272.2_Missense_Mutation_p.P395S|HERC4_ENST00000277817.6_Missense_Mutation_p.P285S|HERC4_ENST00000395187.2_3'UTR	NM_022079.2	NP_071362.1	Q5GLZ8	HERC4_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 4	395					cell differentiation|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|spermatogenesis	cytosol	ubiquitin-protein ligase activity			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(13)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	27						TGCTTTGTCGGATTGGGACAT	0.393000													34	44					0	0	0.000953801	0	0
OR10G4	390264	broad.mit.edu	37	11	123887211	123887211	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:123887211G>A	ENST00000320891.4	+	1	930	c.930G>A	c.(928-930)agG>agA	p.R310R		NM_001004462.1	NP_001004462.1	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G, member 4	310					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(19)|ovary(1)|prostate(1)|skin(4)|stomach(6)|upper_aerodigestive_tract(1)	48		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		ATCCTCAGAGGAAATAAATAC	0.348000													17	29					0	0	0.00121646	0	0
DAB2	1601	broad.mit.edu	37	5	39381617	39381617	+	Silent	SNP	G	G	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:39381617G>C	ENST00000545653.1	-	10	1910	c.1380C>G	c.(1378-1380)ccC>ccG	p.P460P	DAB2_ENST00000339788.6_Silent_p.P263P|DAB2_ENST00000320816.6_Silent_p.P481P|DAB2_ENST00000509337.1_Silent_p.P460P	NM_001244871.1	NP_001231800.1	P98082	DAB2_HUMAN	Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)	481					cell proliferation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of transcription, DNA-dependent|positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway	clathrin coated vesicle membrane|coated pit	protein C-terminus binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(9)|lung(19)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)	47	all_lung(31;0.000197)		Epithelial(62;0.137)			CCAGAGGGTTGGGCTGCAGGG	0.537000													28	96					0	0	0.00209593	0	0
ELP3	55140	broad.mit.edu	37	8	27957418	27957418	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:27957418C>T	ENST00000256398.8	+	3	570	c.193C>T	c.(193-195)Cct>Tct	p.P65S	ELP3_ENST00000380353.4_Intron|ELP3_ENST00000521015.1_Missense_Mutation_p.P51S|ELP3_ENST00000542181.1_Intron|ELP3_ENST00000537665.1_5'UTR|ELP3_ENST00000523760.1_3'UTR|ELP3_ENST00000524103.1_5'UTR	NM_018091.5	NP_060561.3	Q9H9T3	ELP3_HUMAN	elongator acetyltransferase complex subunit 3	65					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	histone acetyltransferase activity|iron-sulfur cluster binding|metal ion binding|phosphorylase kinase regulator activity|protein binding			kidney(2)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	10		Ovarian(32;0.0218)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.151)|Colorectal(74;0.183)		TGCTGCCGTCCCTCCTCAGTA	0.502000													22	56					0	0	0.00047179	0	0
C9orf131	138724	broad.mit.edu	37	9	35045666	35045666	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:35045666G>A	ENST00000312292.5	+	2	3087	c.3040G>A	c.(3040-3042)Ggt>Agt	p.G1014S	C9orf131_ENST00000421362.2_Missense_Mutation_p.G966S|C9orf131_ENST00000354479.5_Missense_Mutation_p.G941S	NM_001040410.1|NM_203299.2	NP_001035500.1|NP_976044.2	Q5VYM1	CI131_HUMAN	chromosome 9 open reading frame 131	1014										cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(23)|prostate(2)|skin(2)|stomach(1)	39	all_epithelial(49;0.22)		LUSC - Lung squamous cell carcinoma(32;0.00117)|Lung(28;0.00309)			CAAAGCTTCGGGTCCCCAGGA	0.577000													19	26					0	0	0.00074312	0	0
CTSL	1514	broad.mit.edu	37	9	90345972	90345972	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:90345972C>T	ENST00000343150.5	+	8	1842	c.952C>T	c.(952-954)Cgg>Tgg	p.R318W	CTSL_ENST00000495822.1_3'UTR|CTSL_ENST00000340342.6_Missense_Mutation_p.R318W					cathepsin L																		GGCCAAAGACCGGAGAAACCA	0.522000													9	15					0	0	0.000673444	0	0
OR1C1	26188	broad.mit.edu	37	1	247921054	247921054	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:247921054C>T	ENST00000408896.2	-	1	928	c.655G>A	c.(655-657)Gga>Aga	p.G219R		NM_012353.2	NP_036485.2	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C, member 1	219					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.G219*(1)		central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(32)|skin(2)|upper_aerodigestive_tract(1)	46	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			AAGATAAGTCCATAAGATACG	0.483000													27	29					0	0	0.00209593	0	0
TNMD	64102	broad.mit.edu	37	X	99854661	99854661	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:99854661C>T	ENST00000373031.4	+	7	1118	c.901C>T	c.(901-903)Cgt>Tgt	p.R301C		NM_022144.2	NP_071427.2	Q9H2S6	TNMD_HUMAN	tenomodulin	301						integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(7)|skin(1)	16						AGTCATCTGTCGTGTCATCAT	0.507000													8	30					0	0	0.000978159	0	0
ACOT8	10005	broad.mit.edu	37	20	44477272	44477272	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:44477272C>T	ENST00000217455.4	-	3	395	c.305G>A	c.(304-306)cGa>cAa	p.R102Q		NM_005469.3	NP_005460.2	O14734	ACOT8_HUMAN	acyl-CoA thioesterase 8	102					bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase|interspecies interaction between organisms|peroxisome organization	peroxisomal matrix	acetyl-CoA hydrolase activity|acyl-CoA thioesterase activity|carboxylesterase activity|choloyl-CoA hydrolase activity|protein binding			kidney(2)|large_intestine(3)|lung(4)|skin(1)	10		Myeloproliferative disorder(115;0.0122)				CGACCCTGTTCGTGTCCGCTC	0.627000													9	34					0	0	0.000673444	0	0
FGA	2243	broad.mit.edu	37	4	155506800	155506800	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:155506800G>A	ENST00000302053.3	-	5	1859	c.1781C>T	c.(1780-1782)tCc>tTc	p.S594F	FGA_ENST00000403106.3_Missense_Mutation_p.S594F	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	594					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	TTCAAATGTGGAGTCTCCTCT	0.453000													24	65					0	0	0.00047179	0	0
ADAMTS15	170689	broad.mit.edu	37	11	130332616	130332616	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:130332616G>A	ENST00000299164.2	+	4	1483	c.1483G>A	c.(1483-1485)Gag>Aag	p.E495K		NM_139055.2	NP_620686.1	Q8TE58	ATS15_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 15	495	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(16)|pancreas(1)|prostate(1)|skin(8)|urinary_tract(1)	36	all_hematologic(175;0.0429)	Lung NSC(97;0.000601)|Breast(109;0.000962)|all_lung(97;0.00125)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0631)|Lung(977;0.215)		CAGCTGTGGCGAGGGCAAGCT	0.642000													24	63					0	0	0.000878237	0	0
ANKRD13D	338692	broad.mit.edu	37	11	67059550	67059550	+	Silent	SNP	A	A	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:67059550A>T	ENST00000447274.2	+	6	1544	c.369A>T	c.(367-369)acA>acT	p.T123T	ANKRD13D_ENST00000308440.6_Silent_p.T123T|ANKRD13D_ENST00000511455.2_Silent_p.T210T|ANKRD13D_ENST00000514166.1_Silent_p.T123T			Q6ZTN6	AN13D_HUMAN	ankyrin repeat domain 13 family, member D	123										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			AGCCCGAAACACTGCTGGCCG	0.637000													17	41					0	0	0.00074312	0	0
OR5M1	390168	broad.mit.edu	37	11	56380724	56380724	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:56380724G>A	ENST00000526538.1	-	1	254	c.255C>T	c.(253-255)ttC>ttT	p.F85F		NM_001004740.1	NP_001004740.1	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M, member 1	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F85F(1)		central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(7)|upper_aerodigestive_tract(1)	12						GTTCTGAGAGGAAATTGTGCA	0.448000													10	70					0	0	0.000442599	0	0
SSH1	54434	broad.mit.edu	37	12	109186494	109186494	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:109186494G>A	ENST00000326495.5	-	14	1554	c.1461C>T	c.(1459-1461)acC>acT	p.T487T	SSH1_ENST00000360239.3_Silent_p.T175T|SSH1_ENST00000326470.5_Silent_p.T498T|SSH1_ENST00000551165.1_Silent_p.T487T	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	487					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GGCTTTCCGGGGTGCCATCTG	0.642000													21	43					0	0	0.00152264	0	0
CARD11	84433	broad.mit.edu	37	7	2952944	2952944	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:2952944A>G	ENST00000396946.4	-	22	3399	c.2996T>C	c.(2995-2997)aTg>aCg	p.M999T		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	999	Guanylate kinase-like.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		GGTGAACTCCATGGCACCTCC	0.662000			Mis		DLBCL								24	107					0	0	0.00047179	0	0
IL21	59067	broad.mit.edu	37	4	123542116	123542116	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:123542116G>A	ENST00000264497.3	-	1	108	c.51C>T	c.(49-51)gtC>gtT	p.V17V	IL21-AS1_ENST00000417927.1_RNA	NM_001207006.2|NM_021803.3	NP_001193935.1|NP_068575.1	Q9HBE4	IL21_HUMAN	interleukin 21	10					cell maturation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-17 production|positive regulation of T cell proliferation|signal transduction	extracellular space	cytokine activity|interleukin-2 receptor binding			NS(1)|kidney(1)|large_intestine(2)|liver(1)|lung(3)	8						CCAAGAAGATGACCATCAGAC	0.443000													27	52					0	0	0.000878237	0	0
ISLR	3671	broad.mit.edu	37	15	74467238	74467238	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:74467238G>A	ENST00000249842.3	+	2	396	c.39G>A	c.(37-39)ctG>ctA	p.L13L	ISLR_ENST00000395118.1_Silent_p.L13L|RP11-665J16.1_ENST00000561647.1_RNA	NM_005545.3	NP_005536.1	O14498	ISLR_HUMAN	immunoglobulin superfamily containing leucine-rich repeat	13					cell adhesion	extracellular region				central_nervous_system(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	20						CGCTTCTCCTGGGCCTGGCTC	0.632000													15	45					0	0	0.000566183	0	0
CLEC4M	10332	broad.mit.edu	37	19	7830105	7830105	+	Silent	SNP	C	C	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:7830105C>A	ENST00000327325.5	+	3	283	c.165C>A	c.(163-165)ctC>ctA	p.L55L	CLEC4M_ENST00000248228.4_Silent_p.L55L|CLEC4M_ENST00000334806.5_Silent_p.L27L|CLEC4M_ENST00000357361.2_Silent_p.L55L|CLEC4M_ENST00000596707.1_Intron|CLEC4M_ENST00000597522.1_Silent_p.L55L|CLEC4M_ENST00000596363.1_Silent_p.L27L|CLEC4M_ENST00000394122.2_Silent_p.L47L|CLEC4M_ENST00000359059.5_Intron|CLEC4M_ENST00000595496.1_Intron	NM_001144909.1|NM_014257.4	NP_001138381.1|NP_055072.3	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M	55					cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(1)	26						TGCTGCAACTCCTCTCCTTCA	0.637000													23	58					3.65163e-15	1.79641e-14	0.00106085	1	0
COL4A5	1287	broad.mit.edu	37	X	107846280	107846280	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:107846280C>T	ENST00000328300.6	+	28	2477	c.2233C>T	c.(2233-2235)Cca>Tca	p.P745S	COL4A5_ENST00000361603.2_Missense_Mutation_p.P745S	NM_033380.2	NP_203699.1	P29400	CO4A5_HUMAN	collagen, type IV, alpha 5	745	Triple-helical region.				axon guidance	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(25)|lung(32)|ovary(4)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	99						ACCCGGCTTTCCAGGACCAAA	0.458000									Alport syndrome with Diffuse Leiomyomatosis				4	8					0	0	0.00024832	0	0
PJA1	64219	broad.mit.edu	37	X	68381749	68381749	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:68381749G>A	ENST00000361478.1	-	2	1710	c.1333C>T	c.(1333-1335)Cga>Tga	p.R445*	PJA1_ENST00000374571.4_Nonsense_Mutation_p.R390*|PJA1_ENST00000374583.1_Nonsense_Mutation_p.R445*|PJA1_ENST00000374584.3_Nonsense_Mutation_p.R257*	NM_001032396.2|NM_022368.4|NM_145119.3	NP_001027568.1|NP_071763.2|NP_660095.1	Q8NG27	PJA1_HUMAN	praja ring finger 1, E3 ubiquitin protein ligase	445							zinc ion binding			endometrium(3)|large_intestine(5)|lung(12)|ovary(1)	21						GATGGTTCTCGAACTTCTTCA	0.577000													51	88					0	0	0.000781405	0	0
EVX1	2128	broad.mit.edu	37	7	27284840	27284840	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:27284840G>A	ENST00000496902.4	+	2	1087	c.601G>A	c.(601-603)Gaa>Aaa	p.E201K	EVX1_ENST00000535619.1_Missense_Mutation_p.E19K|EVX1_ENST00000222761.3_Silent_p.R182R|EVX1-AS_ENST00000517726.1_RNA			P49640	EVX1_HUMAN	even-skipped homeobox 1	201						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|liver(1)|lung(10)|prostate(1)|skin(1)	14						GCTGGAGAAGGAATTCTACCG	0.647000													26	64					0	0	0.000586117	0	0
SAMD7	344658	broad.mit.edu	37	3	169656266	169656266	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:169656266G>A	ENST00000428432.2	+	9	1702	c.1313G>A	c.(1312-1314)gGa>gAa	p.G438E	SAMD7_ENST00000335556.3_Missense_Mutation_p.G438E	NM_182610.2	NP_872416.1	Q7Z3H4	SAMD7_HUMAN	sterile alpha motif domain containing 7	438										NS(1)|biliary_tract(1)|breast(1)|kidney(1)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	31	all_cancers(22;1.55e-22)|all_epithelial(15;2.41e-27)|all_lung(20;3.52e-17)|Lung NSC(18;1.44e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0106)			ATTCCTAAAGGAATTGAGCGA	0.408000													9	17					0	0	0.00136819	0	0
ZNF812	729648	broad.mit.edu	37	19	9801338	9801338	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:9801338C>T	ENST00000457674.2	-	5	1359	c.841G>A	c.(841-843)Gaa>Aaa	p.E281K	ZNF812_ENST00000536819.1_5'UTR	NM_001199814.1	NP_001186743.1	P0C7V5	ZN812_HUMAN	zinc finger protein 812	281					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTCCCACATTCCGTATATTTG	0.378000													12	46					0	0	0.00136819	0	0
SNAPC1	6617	broad.mit.edu	37	14	62245615	62245615	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr14:62245615C>T	ENST00000216294.4	+	7	916	c.812C>T	c.(811-813)tCa>tTa	p.S271L		NM_003082.3	NP_003073.1	Q16533	SNPC1_HUMAN	small nuclear RNA activating complex, polypeptide 1, 43kDa	271					regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	DNA binding			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)	13				OV - Ovarian serous cystadenocarcinoma(108;0.0639)|BRCA - Breast invasive adenocarcinoma(234;0.186)		AAGGCCTTTTCAGTTGTCATA	0.279000													18	42					0	0	0.00188189	0	0
C3orf30	152405	broad.mit.edu	37	3	118866052	118866052	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:118866052A>C	ENST00000295622.1	+	1	1056	c.1016A>C	c.(1015-1017)cAc>cCc	p.H339P		NM_152539.2	NP_689752.2	Q96M34	CC030_HUMAN	chromosome 3 open reading frame 30	339								p.H339L(1)		NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(20)|ovary(2)|prostate(1)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(114;0.222)		GACAATGCTCACTACACTGAA	0.468000													17	31					0	0	0.00188189	0	0
GPR98	84059	broad.mit.edu	37	5	89979723	89979723	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:89979723G>A	ENST00000405460.2	+	28	6081	c.5985G>A	c.(5983-5985)caG>caA	p.Q1995Q		NM_032119.3	NP_115495.3	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98	1995					cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(4)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(3)|kidney(18)|large_intestine(46)|liver(2)|lung(80)|ovary(12)|pancreas(5)|prostate(1)|skin(50)|stomach(7)|upper_aerodigestive_tract(8)|urinary_tract(6)	269		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AAGCAACCCAGAACATCACAC	0.368000													11	6					0	0	0.000978159	0	0
ASPHD1	253982	broad.mit.edu	37	16	29912595	29912595	+	Silent	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:29912595A>G	ENST00000308748.5	+	1	555	c.303A>G	c.(301-303)caA>caG	p.Q101Q	ASPHD1_ENST00000483405.1_Intron	NM_181718.3	NP_859069.2	Q5U4P2	ASPH1_HUMAN	aspartate beta-hydroxylase domain containing 1	101					peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			endometrium(4)|large_intestine(2)|lung(1)|prostate(1)	8						TGGGCTCCCAAGACATGCAGG	0.701000													18	61					0	0	0.00229938	0	0
MISP	126353	broad.mit.edu	37	19	758513	758513	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:758513C>T	ENST00000215582.6	+	2	1670	c.1567C>T	c.(1567-1569)Ccc>Tcc	p.P523S		NM_173481.2	NP_775752.1			mitotic spindle positioning																		GGCCCAAGTCCCCCATGTCTG	0.667000													12	32					0	0	0.00136819	0	0
TRPC5	7224	broad.mit.edu	37	X	111090377	111090377	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:111090377C>T	ENST00000262839.2	-	6	2583	c.1665G>A	c.(1663-1665)ggG>ggA	p.G555G		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	555					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						CACATCGGATCCCCTTGCAGT	0.403000													51	129					0	0	0.000781405	0	0
FKBP15	23307	broad.mit.edu	37	9	115930838	115930838	+	Splice_Site	SNP	T	T	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:115930838T>C	ENST00000238256.3	-	27	3603		c.e27-2			NM_015258.1	NP_056073.1	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa						endocytosis|protein folding	axon|early endosome	actin binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(9)|ovary(3)|urinary_tract(1)	26						CCAGAGAGACTGAAGGAAAAT	0.498000													20	36					0	0	0.00229938	0	0
ATF7	11016	broad.mit.edu	37	12	53928439	53928439	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:53928439A>G	ENST00000420353.2	-	6	556	c.407T>C	c.(406-408)gTt>gCt	p.V136A	ATF7_ENST00000415113.1_Missense_Mutation_p.V115A|ATF7_ENST00000548446.2_Missense_Mutation_p.V147A|RP11-793H13.10_ENST00000591834.1_Missense_Mutation_p.V136A|ATF7_ENST00000456903.4_Missense_Mutation_p.V136A|ATF7_ENST00000328463.7_Missense_Mutation_p.V147A	NM_006856.2	NP_006847.1	P17544	ATF7_HUMAN	activating transcription factor 7	147	Transactivation domain.				interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(1)|ovary(1)|skin(1)|urinary_tract(1)	9						CTTTGGGGTAACCTCCTGGAG	0.433000													11	45					0	0	0.000978159	0	0
CDC37L1	55664	broad.mit.edu	37	9	4697103	4697103	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:4697103G>A	ENST00000381854.3	+	4	718	c.516G>A	c.(514-516)ttG>ttA	p.L172L	CDC37L1_ENST00000381858.1_Silent_p.L172L	NM_017913.2	NP_060383.2	Q7L3B6	CD37L_HUMAN	cell division cycle 37-like 1	172	Self-association and interaction with Hsp90.					cytoplasm				breast(1)|kidney(1)|lung(2)	4	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.0318)		CAGGTATGTTGAGTCGATGGG	0.338000													6	45					0	0	0.00198382	0	0
CHRNA9	55584	broad.mit.edu	37	4	40356123	40356123	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:40356123G>A	ENST00000310169.2	+	5	1165	c.1026G>A	c.(1024-1026)ctG>ctA	p.L342L		NM_017581.3	NP_060051.2	Q9UGM1	ACHA9_HUMAN	cholinergic receptor, nicotinic, alpha 9 (neuronal)	342					elevation of cytosolic calcium ion concentration|synaptic transmission	cell junction|postsynaptic membrane	calcium channel activity|receptor activity			breast(4)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|prostate(3)|skin(4)|stomach(1)	33					Nicotine(DB00184)	TGGTCATCCTGAAATACATGT	0.557000													86	168					0	0	0.000781405	0	0
TRIM37	4591	broad.mit.edu	37	17	57125123	57125123	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:57125123G>A	ENST00000376149.3	-	16	2031	c.1222C>T	c.(1222-1224)Cag>Tag	p.Q408*	TRIM37_ENST00000393066.3_Nonsense_Mutation_p.Q530*|TRIM37_ENST00000393065.2_Nonsense_Mutation_p.Q496*|TRIM37_ENST00000262294.7_Nonsense_Mutation_p.Q530*			O94972	TRI37_HUMAN	tripartite motif containing 37	530						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(13)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					CCATCGAGCTGATTTACTTCA	0.393000									Mulibrey Nanism				6	24					0	0	0.000157383	0	0
ANK3	288	broad.mit.edu	37	10	61868658	61868658	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:61868658G>A	ENST00000280772.1	-	27	3294	c.3103C>T	c.(3103-3105)Ccc>Tcc	p.P1035S	ANK3_ENST00000355288.2_Missense_Mutation_p.P169S|ANK3_ENST00000503366.1_Missense_Mutation_p.P1036S|ANK3_ENST00000373827.2_Missense_Mutation_p.P1029S	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1035	ZU5.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding	p.P1035S(1)		NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TCCACCATGGGGGGTGGGTTG	0.502000													23	33					0	0	0.00278032	0	0
ITPR1	3708	broad.mit.edu	37	3	4847917	4847917	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:4847917G>A	ENST00000302640.8	+	54	7543	c.7193G>A	c.(7192-7194)gGg>gAg	p.G2398E	ITPR1_ENST00000423119.2_Missense_Mutation_p.G2365E|ITPR1_ENST00000357086.4_Missense_Mutation_p.G2365E|ITPR1_ENST00000354582.6_Missense_Mutation_p.G2398E|ITPR1_ENST00000443694.2_Missense_Mutation_p.G2398E|ITPR1_ENST00000456211.2_Missense_Mutation_p.G2350E|ITPR1_ENST00000463980.1_3'UTR|ITPR1_ENST00000544951.1_Missense_Mutation_p.G376E	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2413					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		TGTGCCATGGGGCTCTTTGTC	0.468000													15	73					0	0	0.000422831	0	0
ZNF414	84330	broad.mit.edu	37	19	8577592	8577592	+	Missense_Mutation	SNP	T	T	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:8577592T>A	ENST00000393927.4	-	3	433	c.320A>T	c.(319-321)aAg>aTg	p.K107M	ZNF414_ENST00000255616.8_Missense_Mutation_p.K107M	NM_001146175.1	NP_001139647.1	Q96IQ9	ZN414_HUMAN	zinc finger protein 414	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			lung(2)	2						AGGGATTTGCTTCCCTGCAGG	0.602000													4	0					0	0	0.000602214	0	0
OR2M4	26245	broad.mit.edu	37	1	248402764	248402764	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:248402764C>T	ENST00000306687.1	+	1	534	c.534C>T	c.(532-534)ttC>ttT	p.F178F		NM_017504.1	NP_059974.1	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M, member 4	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(27)|skin(3)|upper_aerodigestive_tract(2)	50	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			ATCACTTTTTCTGTGATGTTG	0.428000													50	90					0	0	0.000781405	0	0
INPP5J	27124	broad.mit.edu	37	22	31522380	31522380	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr22:31522380G>A	ENST00000331075.5	+	3	1339	c.1290G>A	c.(1288-1290)tgG>tgA	p.W430*	INPP5J_ENST00000400294.2_Nonsense_Mutation_p.W63*|INPP5J_ENST00000412277.2_Nonsense_Mutation_p.W363*|INPP5J_ENST00000405300.1_Nonsense_Mutation_p.W63*|INPP5J_ENST00000404390.3_Nonsense_Mutation_p.W62*			Q15735	PI5PA_HUMAN	inositol polyphosphate-5-phosphatase J	430	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(5)|skin(1)	12						TGGTCACATGGAACGTGGGCA	0.612000													45	94					0	0	0.000781405	0	0
ELOVL1	64834	broad.mit.edu	37	1	43830677	43830677	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:43830677G>A	ENST00000372458.3	-	4	357	c.240C>T	c.(238-240)ttC>ttT	p.F80F	ELOVL1_ENST00000470769.1_5'UTR|ELOVL1_ENST00000413844.2_Intron	NM_001256399.1|NM_001256402.1|NM_022821.3	NP_001243328.1|NP_001243331.1|NP_073732.1	Q9BW60	ELOV1_HUMAN	ELOVL fatty acid elongase 1	80					fatty acid elongation, monounsaturated fatty acid|fatty acid elongation, saturated fatty acid|long-chain fatty-acyl-CoA biosynthetic process|sphingolipid biosynthetic process|triglyceride biosynthetic process|very long-chain fatty acid biosynthetic process	integral to endoplasmic reticulum membrane	fatty acid elongase activity|protein binding			endometrium(1)|kidney(1)|large_intestine(1)|prostate(1)	4	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCGACATCAGGAACTGGGAAG	0.577000													6	17					0	0	0.00116845	0	0
KCNT2	343450	broad.mit.edu	37	1	196397273	196397273	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:196397273C>T	ENST00000367433.5	-	10	1047	c.946G>A	c.(946-948)Gat>Aat	p.D316N	KCNT2_ENST00000367431.4_Missense_Mutation_p.D316N|KCNT2_ENST00000451324.2_Intron|KCNT2_ENST00000498426.1_5'UTR|KCNT2_ENST00000294725.8_Missense_Mutation_p.D316N			Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	316						voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(16)|lung(43)|ovary(5)|pancreas(1)|prostate(1)|skin(11)|stomach(2)|upper_aerodigestive_tract(1)	97						TTTAAAAAATCCATAAGTAAA	0.378000													13	45					0	0	0.00185496	0	0
LPAR1	1902	broad.mit.edu	37	9	113703966	113703966	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:113703966G>A	ENST00000374431.3	-	4	911	c.528C>T	c.(526-528)atC>atT	p.I176I	LPAR1_ENST00000541779.1_Silent_p.I177I|LPAR1_ENST00000358883.4_Silent_p.I176I|LPAR1_ENST00000538760.1_Silent_p.I177I|LPAR1_ENST00000374430.2_Silent_p.I176I	NM_057159.2	NP_476500.1	Q92633	LPAR1_HUMAN	lysophosphatidic acid receptor 1	176					positive regulation of I-kappaB kinase/NF-kappaB cascade	cell surface|integral to plasma membrane				breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(1)|ovary(2)|prostate(6)|skin(1)	21						CACCCATAACGATGGCCATAG	0.498000													26	32					0	0	0.000720815	0	0
ITGA5	3678	broad.mit.edu	37	12	54798666	54798666	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:54798666C>T	ENST00000293379.4	-	13	1499	c.1238G>A	c.(1237-1239)gGg>gAg	p.G413E	RP11-753H16.3_ENST00000550474.1_RNA|RP11-753H16.5_ENST00000552785.1_RNA	NM_002205.2	NP_002196.2	P08648	ITA5_HUMAN	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	413					angiogenesis|axon guidance|blood coagulation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte migration|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway|wound healing, spreading of epidermal cells	alphav-beta3 integrin-vitronectin complex|integrin complex|ruffle	platelet-derived growth factor receptor binding|receptor activity|vascular endothelial growth factor receptor 2 binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(11)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	34						AAAGGGAGCCCCGATGGCCAC	0.582000											OREG0021554	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	9					0	0	6.4e-05	0	0
XIRP2	129446	broad.mit.edu	37	2	168097208	168097208	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:168097208A>G	ENST00000409195.1	+	7	1093	c.1004A>G	c.(1003-1005)aAc>aGc	p.N335S	XIRP2_ENST00000409273.1_Missense_Mutation_p.N113S|XIRP2_ENST00000295237.9_Missense_Mutation_p.N335S|XIRP2_ENST00000409605.1_Missense_Mutation_p.N113S|XIRP2_ENST00000409756.2_Missense_Mutation_p.N335S|XIRP2_ENST00000420519.1_Missense_Mutation_p.N368S|XIRP2_ENST00000409728.1_Missense_Mutation_p.N368S|XIRP2_ENST00000409043.1_Missense_Mutation_p.N335S	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	160					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GAGGAAGTAAACCAAGCATCT	0.308000													25	67					0	0	0.00106085	0	0
ALAS2	212	broad.mit.edu	37	X	55043923	55043923	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:55043923C>T	ENST00000330807.5	-	7	1136	c.999G>A	c.(997-999)atG>atA	p.M333I	ALAS2_ENST00000396198.3_Missense_Mutation_p.M320I|ALAS2_ENST00000335854.4_Missense_Mutation_p.M296I|ALAS2_ENST00000498636.1_5'UTR	NM_000032.4	NP_000023.2	P22557	HEM0_HUMAN	aminolevulinate, delta-, synthase 2	333					cellular iron ion homeostasis|erythrocyte differentiation|heme biosynthetic process|hemoglobin biosynthetic process|oxygen homeostasis|response to hypoxia	mitochondrial inner membrane|mitochondrial matrix	5-aminolevulinate synthase activity|coenzyme binding|glycine binding|protein binding|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			central_nervous_system(1)|kidney(2)|large_intestine(6)|lung(4)|ovary(1)|prostate(2)|skin(1)	17					Glycine(DB00145)	ACATACCATCCATGGAGTGGA	0.393000													34	70					0	0	0.000692331	0	0
IKZF2	22807	broad.mit.edu	37	2	213872225	213872225	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:213872225G>A	ENST00000457361.1	-	8	1608	c.1440C>T	c.(1438-1440)ttC>ttT	p.F480F	IKZF2_ENST00000451136.2_Silent_p.F408F|IKZF2_ENST00000374319.4_Silent_p.F454F|IKZF2_ENST00000434687.1_Silent_p.F480F|IKZF2_ENST00000374327.4_Silent_p.F335F|IKZF2_ENST00000421754.2_Silent_p.F406F|IKZF2_ENST00000342002.2_Silent_p.F486F|IKZF2_ENST00000413091.3_3'UTR	NM_016260.2	NP_057344.2	Q9UKS7	IKZF2_HUMAN	IKAROS family zinc finger 2 (Helios)	480					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(7)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Esophageal squamous(248;0.0559)|Renal(323;0.218)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;2.97e-07)|all cancers(144;1.53e-05)|LUSC - Lung squamous cell carcinoma(224;0.00599)|Lung(261;0.00792)		CATGGTCTAGGAAAAGGACTC	0.512000													37	71					0	0	0.00148497	0	0
INIP	58493	broad.mit.edu	37	9	115456459	115456459	+	Missense_Mutation	SNP	C	C	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:115456459C>G	ENST00000374242.4	-	3	385	c.80G>C	c.(79-81)aGa>aCa	p.R27T	INIP_ENST00000374238.1_5'UTR|INIP_ENST00000497712.2_5'UTR|INIP_ENST00000374234.1_5'UTR|INIP_ENST00000374236.1_5'UTR	NM_021218.1	NP_067041.1			INTS3 and NABP interacting protein																		AAGTAGTTTTCTTTTCTCTTT	0.343000													27	63					0	0	0.00283554	0	0
FGR	2268	broad.mit.edu	37	1	27939754	27939754	+	Missense_Mutation	SNP	T	T	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:27939754T>G	ENST00000374005.3	-	12	1645	c.1357A>C	c.(1357-1359)Acc>Ccc	p.T453P	FGR_ENST00000399173.1_Missense_Mutation_p.T453P|FGR_ENST00000374004.1_Missense_Mutation_p.T453P|FGR_ENST00000545953.1_Missense_Mutation_p.T387P	NM_005248.2	NP_005239.1	P09769	FGR_HUMAN	feline Gardner-Rasheed sarcoma viral oncogene homolog	453	Protein kinase.				platelet activation|response to virus	cytosol	ATP binding|non-membrane spanning protein tyrosine kinase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(4)	16		all_lung(284;2.05e-05)|Colorectal(325;3.46e-05)|Lung NSC(340;3.67e-05)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.25e-24)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00244)|KIRC - Kidney renal clear cell carcinoma(1967;0.0027)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		CGGCCCTTGGTGATGAGCTCA	0.602000													16	50					0	0	0.000566183	0	0
PLCB4	5332	broad.mit.edu	37	20	9317777	9317777	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:9317777C>T	ENST00000378501.2	+	2	104	c.89C>T	c.(88-90)tCc>tTc	p.S30F	PLCB4_ENST00000378473.3_Missense_Mutation_p.S30F|PLCB4_ENST00000414679.2_Missense_Mutation_p.S30F|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Missense_Mutation_p.S30F|PLCB4_ENST00000334005.3_Missense_Mutation_p.S30F|PLCB4_ENST00000378493.1_Missense_Mutation_p.S30F	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	30					intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						TGACAGGAATCCTTTGTGTTT	0.373000													20	64					0	0	0.00278032	0	0
FAM227B	196951	broad.mit.edu	37	15	49833925	49833925	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:49833925C>T	ENST00000299338.6	-	10	1129	c.826G>A	c.(826-828)Gat>Aat	p.D276N	FAM227B_ENST00000561064.1_Missense_Mutation_p.D242N	NM_152647.2	NP_689860.2			family with sequence similarity 227, member B																		TTAAATTCATCATTAAAGAGG	0.284000													30	131					0	0	0.00058488	0	0
NAF1	92345	broad.mit.edu	37	4	164066932	164066932	+	Splice_Site	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:164066932A>G	ENST00000274054.2	-	4	911		c.e4+1		NAF1_ENST00000422287.2_Splice_Site	NM_138386.2	NP_612395.2	Q96HR8	NAF1_HUMAN	nuclear assembly factor 1 ribonucleoprotein						rRNA processing|snRNA pseudouridine synthesis	cytoplasm|nucleus|small nucleolar ribonucleoprotein complex	protein binding|snoRNA binding			NS(1)|autonomic_ganglia(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(10)|ovary(2)	21	all_hematologic(180;0.166)	Prostate(90;0.109)				TGTTTTACAAACCTTTCCTGC	0.274000													3	8					0	0	6.4e-05	0	0
SIDT1	54847	broad.mit.edu	37	3	113300282	113300282	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:113300282C>T	ENST00000264852.4	+	6	1464	c.738C>T	c.(736-738)atC>atT	p.I246I	SIDT1_ENST00000393830.3_Silent_p.I246I	NM_017699.2	NP_060169.2	Q9NXL6	SIDT1_HUMAN	SID1 transmembrane family, member 1	246						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(9)|kidney(1)|large_intestine(11)|liver(2)|lung(15)|ovary(3)|pancreas(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	50						AAGCTGCCATCACGCTACAGG	0.468000													22	35					0	0	0.00229938	0	0
WFS1	7466	broad.mit.edu	37	4	6303919	6303919	+	Silent	SNP	C	C	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:6303919C>A	ENST00000226760.1	+	8	2567	c.2397C>A	c.(2395-2397)acC>acA	p.T799T	WFS1_ENST00000503569.1_Silent_p.T799T	NM_001145853.1|NM_006005.3	NP_001139325.1|NP_005996.2	O76024	WFS1_HUMAN	Wolfram syndrome 1 (wolframin)	799					endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	21				Colorectal(103;0.0512)		ACGACGTCACCAAGGACATCG	0.632000													8	254					0.000157383	0.0007678	0.000157383	1	0
RBM11	54033	broad.mit.edu	37	21	15592007	15592007	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr21:15592007C>T	ENST00000400577.3	+	2	229	c.220C>T	c.(220-222)Cgt>Tgt	p.R74C	RBM11_ENST00000468643.1_3'UTR	NM_144770.3	NP_658983.3	P57052	RBM11_HUMAN	RNA binding motif protein 11	74	RRM.						nucleotide binding|RNA binding			endometrium(3)|kidney(3)|lung(7)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	16				Epithelial(23;0.000314)|COAD - Colon adenocarcinoma(22;0.00242)|Colorectal(24;0.0129)|Lung(58;0.141)		GAATGGAATTCGTTTATATGG	0.388000													19	34					0	0	0.00074312	0	0
MAPK6	5597	broad.mit.edu	37	15	52356254	52356254	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:52356254A>G	ENST00000261845.5	+	6	2030	c.1223A>G	c.(1222-1224)aAg>aGg	p.K408R	CTD-2184D3.5_ENST00000558607.1_RNA	NM_002748.3	NP_002739.1	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	408					cell cycle		ATP binding|MAP kinase activity			breast(3)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	20				all cancers(107;0.0028)		GATCGGGAAAAGTATCTGGAG	0.408000													13	40					0	0	0.00244969	0	0
IL1F10	84639	broad.mit.edu	37	2	113832364	113832364	+	Silent	SNP	C	C	T	rs34320972	byFrequency	TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:113832364C>T	ENST00000393197.2	+	3	604	c.183C>T	c.(181-183)atC>atT	p.I61I	IL1F10_ENST00000337569.3_Silent_p.I61I|IL1F10_ENST00000341010.2_Silent_p.I61I	NM_032556.5	NP_115945.4	Q8WWZ1	IL1FA_HUMAN	interleukin 1 family, member 10 (theta)	61						extracellular space	cytokine activity|interleukin-1 receptor antagonist activity	p.I61I(2)		endometrium(1)|lung(6)|ovary(1)	8						TCCTGGGGATCCAGGGAGGGA	0.582000													25	46					0	0	0.000878237	0	0
OR5D18	219438	broad.mit.edu	37	11	55587319	55587319	+	Missense_Mutation	SNP	T	T	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:55587319T>A	ENST00000333976.4	+	1	234	c.214T>A	c.(214-216)Ttc>Atc	p.F72I		NM_001001952.1	NP_001001952.1	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D, member 18	72					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(3)|large_intestine(6)|lung(33)|ovary(1)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55		all_epithelial(135;0.208)				CTTTGTGGATTTCTGCTATTC	0.408000													56	107					0	0	0.000781405	0	0
PROKR2	128674	broad.mit.edu	37	20	5282886	5282886	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:5282886C>A	ENST00000546004.1	-	3	1201	c.955G>T	c.(955-957)Gag>Tag	p.E319*	PROKR2_ENST00000217270.3_Nonsense_Mutation_p.E319*			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	319						integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						GCGATGCACTCGACCACGTAG	0.517000										HNSCC(71;0.22)			5	113					0.00116845	0.00566261	0.00116845	1	0
KLHL32	114792	broad.mit.edu	37	6	97561953	97561953	+	Missense_Mutation	SNP	C	C	T	rs35641414		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:97561953C>T	ENST00000369261.4	+	7	1285	c.922C>T	c.(922-924)Cgg>Tgg	p.R308W	KLHL32_ENST00000536676.1_Missense_Mutation_p.R272W|KLHL32_ENST00000544166.1_Intron|KLHL32_ENST00000539200.1_Missense_Mutation_p.R239W	NM_052904.3	NP_443136.2	Q96NJ5	KLH32_HUMAN	kelch-like family member 32	308								p.R308W(1)		breast(2)|endometrium(3)|kidney(4)|large_intestine(9)|lung(13)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	38		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		CAAGGAACTTCGGTACTTCAA	0.527000													24	53					0	0	0.00229938	0	0
METTL13	51603	broad.mit.edu	37	1	171761229	171761229	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:171761229C>T	ENST00000361735.3	+	6	1813	c.1547C>T	c.(1546-1548)cCa>cTa	p.P516L	METTL13_ENST00000367737.5_Missense_Mutation_p.P360L|METTL13_ENST00000466643.1_3'UTR|METTL13_ENST00000362019.3_Missense_Mutation_p.P430L|METTL13_ENST00000458517.1_Missense_Mutation_p.P515L	NM_015935.4	NP_057019.3	Q8N6R0	MTL13_HUMAN	methyltransferase like 13	516							methyltransferase activity|protein binding			breast(3)|cervix(1)|endometrium(4)|kidney(5)|large_intestine(8)|lung(17)|stomach(3)	41						GATCATTTTCCAAAGTCCTGC	0.522000													24	123					0	0	0.000586117	0	0
ZC3H18	124245	broad.mit.edu	37	16	88643604	88643604	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:88643604G>A	ENST00000301011.5	+	2	273	c.73G>A	c.(73-75)Gac>Aac	p.D25N	ZC3H18_ENST00000452588.2_Missense_Mutation_p.D25N	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	25						nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		GGGACTCTCGGACGATGACAT	0.602000													11	25					0	0	0.000978159	0	0
PCDHGA9	56107	broad.mit.edu	37	5	140784766	140784766	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:140784766C>T	ENST00000573521.1	+	1	2247	c.2247C>T	c.(2245-2247)ttC>ttT	p.F749F	PCDHGA2_ENST00000394576.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA6_ENST00000517434.1_Intron	NM_018921.2|NM_032089.1	NP_061744.1|NP_114478.1														endometrium(1)|kidney(1)|lung(3)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCGAGCTTTCCTACAGACCT	0.567000													37	27					0	0	0.000692331	0	0
AHSG	197	broad.mit.edu	37	3	186338685	186338685	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:186338685C>T	ENST00000411641.2	+	7	1289	c.1070C>T	c.(1069-1071)cCa>cTa	p.P357L	AHSG_ENST00000273784.5_Missense_Mutation_p.P358L			P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	357					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(15)|prostate(2)|stomach(1)	22	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		GTGGTTCCTCCATGTCCGGGG	0.562000													12	27					0	0	0.000978159	0	0
C6orf118	168090	broad.mit.edu	37	6	165715373	165715373	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:165715373G>A	ENST00000543069.1	-	2	707	c.126C>T	c.(124-126)ttC>ttT	p.F42F	C6orf118_ENST00000230301.8_Silent_p.F146F			Q5T5N4	CF118_HUMAN	chromosome 6 open reading frame 118	146										breast(1)|kidney(2)|large_intestine(9)|liver(1)|lung(21)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	40		Breast(66;6.27e-05)|Ovarian(120;0.0228)|Prostate(117;0.0906)|all_neural(5;0.157)		OV - Ovarian serous cystadenocarcinoma(33;3.23e-18)|BRCA - Breast invasive adenocarcinoma(81;3.11e-06)|GBM - Glioblastoma multiforme(31;0.000313)		CCACTGGAAGGAAATCCTCCT	0.627000													44	79					0	0	0.000781405	0	0
CCDC19	25790	broad.mit.edu	37	1	159846476	159846476	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:159846476C>T	ENST00000426543.2	-	10	1422	c.967G>A	c.(967-969)Gaa>Aaa	p.E323K	CCDC19_ENST00000368099.4_Missense_Mutation_p.E408K|CCDC19_ENST00000476696.1_5'UTR			Q9UL16	CCD19_HUMAN	coiled-coil domain containing 19	408						mitochondrion|soluble fraction		p.E408delE(1)		endometrium(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	26	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			CGCGCATTTTCCTTTTCCTTT	0.562000													21	45					0	0	0.00121646	0	0
NBEA	26960	broad.mit.edu	37	13	36242646	36242646	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr13:36242646C>T	ENST00000400445.3	+	57	9274	c.8740C>T	c.(8740-8742)Cat>Tat	p.H2914Y	NBEA_ENST00000379939.2_Missense_Mutation_p.H2911Y|NBEA_ENST00000537702.1_Missense_Mutation_p.H707Y|NBEA_ENST00000379922.3_Missense_Mutation_p.H492Y|NBEA_ENST00000310336.4_Missense_Mutation_p.H2914Y|NBEA_ENST00000540320.1_Missense_Mutation_p.H2914Y	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	2914						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GGACTTGTCCCATGACCAGAG	0.493000													19	21					0	0	0.00229938	0	0
LAMC1	3915	broad.mit.edu	37	1	183083683	183083683	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:183083683C>T	ENST00000258341.4	+	5	1296	c.1039C>T	c.(1039-1041)Cga>Tga	p.R347*		NM_002293.3	NP_002284.3	P11047	LAMC1_HUMAN	laminin, gamma 1 (formerly LAMB2)	347	Laminin EGF-like 2.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			NS(2)|breast(5)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(27)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)	76					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTGCAATGGTCGATCCCAGGA	0.468000													35	282					0	0	0.00222228	0	0
OR10A7	121364	broad.mit.edu	37	12	55614962	55614962	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:55614962G>A	ENST00000326258.1	+	1	154	c.154G>A	c.(154-156)Gat>Aat	p.D52N		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	52					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						TACCAGTGTGGATCTCGCACT	0.393000													61	144					0	0	0.000781405	0	0
ARL5A	26225	broad.mit.edu	37	2	152684689	152684689	+	Translation_Start_Site	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:152684689A>G	ENST00000295087.8	-	1	313	c.2T>C	c.(1-3)aTg>aCg	p.M1T	ARL5A_ENST00000428992.2_Intron|ARL5A_ENST00000487723.1_5'UTR	NM_001037174.1|NM_012097.3	NP_001032251.1|NP_036229.1	Q9Y689	ARL5A_HUMAN	ADP-ribosylation factor-like 5A	1					small GTPase mediated signal transduction	intracellular	GTP binding			breast(1)|large_intestine(2)|liver(1)|lung(2)	6				BRCA - Breast invasive adenocarcinoma(221;0.153)		GAGAATTCCCATTCTCGGGCA	0.677000													5	28					0	0	0.000602214	0	0
TMEM37	140738	broad.mit.edu	37	2	120194514	120194514	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:120194514C>T	ENST00000306406.4	+	2	106	c.71C>T	c.(70-72)tCc>tTc	p.S24F	TMEM37_ENST00000465296.1_3'UTR|TMEM37_ENST00000409826.1_Missense_Mutation_p.S36F	NM_183240.2	NP_899063.2	Q8WXS4	CCGL_HUMAN	transmembrane protein 37	24						integral to membrane	calcium channel activity|voltage-gated ion channel activity			breast(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	11						TTCTTTGAATCCTTCATCCGG	0.627000													28	47					0	0	0.00106085	0	0
ZC3H18	124245	broad.mit.edu	37	16	88643603	88643603	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:88643603G>A	ENST00000301011.5	+	2	272	c.72G>A	c.(70-72)tcG>tcA	p.S24S	ZC3H18_ENST00000452588.2_Silent_p.S24S	NM_144604.3	NP_653205.3	Q86VM9	ZCH18_HUMAN	zinc finger CCCH-type containing 18	24						nucleus	nucleic acid binding|zinc ion binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(9)|lung(16)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	42				BRCA - Breast invasive adenocarcinoma(80;0.0542)		AGGGACTCTCGGACGATGACA	0.597000													11	25					0	0	0.000978159	0	0
ROS1	6098	broad.mit.edu	37	6	117645561	117645561	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:117645561C>T	ENST00000368508.3	-	34	5773	c.5575G>A	c.(5575-5577)Gaa>Aaa	p.E1859K	GOPC_ENST00000467125.1_Intron|ROS1_ENST00000368507.3_Missense_Mutation_p.E1853K	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	1859					transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		AAACTTGTTTCTGGTATCCAA	0.294000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								12	26					0	0	0.00136819	0	0
ABCB5	340273	broad.mit.edu	37	7	20767987	20767987	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:20767987C>T	ENST00000404938.2	+	23	3428	c.2776C>T	c.(2776-2778)Cat>Tat	p.H926Y	ABCB5_ENST00000258738.6_Missense_Mutation_p.H481Y	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	481					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						TGCATTCAGCCATGCCTTTAT	0.403000													35	105					0	0	0.000692331	0	0
SNHG14	104472715	broad.mit.edu	37	15	25227215	25227215	+	RNA	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:25227215C>T	ENST00000551631.2	+	0	518				SNHG14_ENST00000551361.1_RNA|SNHG14_ENST00000459433.1_RNA	NR_001293.1																						ACTCTGAAATCCAGTCAGTGT	0.363000													81	145					0	0	0.000781405	0	0
KIF5C	3800	broad.mit.edu	37	2	149806890	149806890	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:149806890G>A	ENST00000435030.1	+	10	1250	c.882G>A	c.(880-882)ggG>ggA	p.G294G	KIF5C_ENST00000397413.1_Silent_p.G62G|KIF5C_ENST00000464066.1_3'UTR|KIF5C_ENST00000414838.2_Silent_p.G199G			O60282	KIF5C_HUMAN	kinesin family member 5C	294	Kinesin-motor.|Microtubule-binding.				microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	36				BRCA - Breast invasive adenocarcinoma(221;0.108)		CTTTGGGTGGGAACTGCAGAA	0.473000													17	30					0	0	0.00074312	0	0
CER1	9350	broad.mit.edu	37	9	14722193	14722193	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:14722193C>T	ENST00000380911.3	-	1	522	c.478G>A	c.(478-480)Gag>Aag	p.E160K		NM_005454.2	NP_005445.1	O95813	CER1_HUMAN	cerberus 1, DAN family BMP antagonist	160					BMP signaling pathway	extracellular space	cytokine activity			endometrium(2)|large_intestine(3)|lung(6)	11				GBM - Glioblastoma multiforme(50;3.16e-06)		CTGCAGGTCTCCCAATGTACT	0.522000													24	23					0	0	0.000586117	0	0
C16orf82	162083	broad.mit.edu	37	16	27078315	27078315	+	RNA	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:27078315C>T	ENST00000505035.1	+	0	288				RP11-673P17.2_ENST00000565783.1_RNA			Q7Z2V1	TNT_HUMAN																			GGCCCCCTCTCCCTGGATAAA	0.537000													19	35					0	0	0.00121646	0	0
CUL5	8065	broad.mit.edu	37	11	107965615	107965615	+	Silent	SNP	T	T	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:107965615T>A	ENST00000393094.2	+	15	2260	c.1644T>A	c.(1642-1644)ccT>ccA	p.P548P		NM_003478.3	NP_003469.2	Q93034	CUL5_HUMAN	cullin 5	548					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			endometrium(2)|kidney(1)|large_intestine(8)|lung(9)|ovary(1)|prostate(1)|skin(1)	23		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		TCTCACTTCCTACTGAACTGG	0.358000													8	52					0	0	0.000274275	0	0
MYH3	4621	broad.mit.edu	37	17	10552993	10552993	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:10552993G>A	ENST00000583535.1	-	7	630	c.543C>T	c.(541-543)tcC>tcT	p.S181S	MYH3_ENST00000226209.7_Silent_p.S181S	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	181	Myosin head-like.				muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TTCCTGCCCCGGATTCTCCGC	0.478000													28	39					0	0	0.00178596	0	0
ATP1A3	478	broad.mit.edu	37	19	42479928	42479928	+	Missense_Mutation	SNP	C	C	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:42479928C>G	ENST00000545399.1	-	16	2308	c.2155G>C	c.(2155-2157)Ggg>Cgg	p.G719R	ATP1A3_ENST00000543770.1_Missense_Mutation_p.G717R|ATP1A3_ENST00000602133.1_Missense_Mutation_p.G676R|ATP1A3_ENST00000302102.5_Missense_Mutation_p.G706R	NM_001256214.1	NP_001243143.1	P13637	AT1A3_HUMAN	ATPase, Na+/K+ transporting, alpha 3 polypeptide	706					ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(19)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	52						ACACCATCCCCGGTCACAGCC	0.617000													12	63					0	0	0.00136819	0	0
FMO1	2326	broad.mit.edu	37	1	171254677	171254677	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:171254677C>T	ENST00000354841.4	+	8	1724	c.1593C>T	c.(1591-1593)ttC>ttT	p.F531F	FMO1_ENST00000402921.2_Silent_p.F468F|FMO1_ENST00000367750.3_Silent_p.F531F|FMO1_ENST00000469112.1_3'UTR			Q01740	FMO1_HUMAN	flavin containing monooxygenase 1	531					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TTCTGATTTTCCTATAAGTAA	0.363000													14	30					0	0	0.00244969	0	0
SNHG14	104472715	broad.mit.edu	37	15	25427525	25427525	+	RNA	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:25427525C>T	ENST00000424208.1	+	0	272					NR_003305.1																						AGGGGGTGCCCTGGGTTGGGT	0.532000													43	127					0	0	0.000781405	0	0
DAPL1	92196	broad.mit.edu	37	2	159663565	159663565	+	Splice_Site	SNP	A	A	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:159663565A>C	ENST00000309950.3	+	3	202		c.e3-1		DAPL1_ENST00000409042.1_Splice_Site	NM_001017920.2	NP_001017920.2	A0PJW8	DAPL1_HUMAN	death associated protein-like 1						apoptosis|cell differentiation					prostate(1)	1						TCATCTTCACAGTGCCATTGC	0.438000													7	18					0	0	0.00198382	0	0
ASTN2	23245	broad.mit.edu	37	9	119188211	119188211	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:119188211G>A	ENST00000313400.4	-	23	4039	c.3939C>T	c.(3937-3939)atC>atT	p.I1313I	ASTN2_ENST00000373996.3_Silent_p.I1309I|ASTN2_ENST00000361477.3_Silent_p.I365I|ASTN2_ENST00000341734.4_Silent_p.I365I|ASTN2_ENST00000361209.2_Silent_p.I1262I|ASTN2_ENST00000288520.5_Silent_p.I414I			O75129	ASTN2_HUMAN	astrotactin 2	1313						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						TGTCCTTGAGGATGCTATACC	0.592000													11	16					0	0	0.000978159	0	0
SLCO5A1	81796	broad.mit.edu	37	8	70667861	70667861	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:70667861G>A	ENST00000260126.3	-	4	1762	c.1056C>T	c.(1054-1056)ctC>ctT	p.L352L	SLCO5A1_ENST00000524945.1_Silent_p.L352L|SLCO5A1_ENST00000530307.1_Silent_p.L352L	NM_030958.2	NP_112220.2	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family, member 5A1	352						integral to membrane|plasma membrane	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(24)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	53	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			TGGCACAAAGGAGGAATCCAC	0.343000													13	24					0	0	0.00136819	0	0
PTCD1	26024	broad.mit.edu	37	7	99032539	99032539	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:99032539G>A	ENST00000292478.4	-	2	577	c.327C>T	c.(325-327)ttC>ttT	p.F109F	ATP5J2-PTCD1_ENST00000413834.1_Silent_p.F158F|PTCD1_ENST00000485746.1_5'UTR|PTCD1_ENST00000555673.1_Silent_p.F158F	NM_015545.3	NP_056360.2			pentatricopeptide repeat domain 1											endometrium(5)|large_intestine(3)|lung(16)|ovary(2)|skin(1)	27	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			GCAGGTTATGGAACTGGGCTG	0.557000													97	112					0	0	0.000781405	0	0
OBSCN	84033	broad.mit.edu	37	1	228494858	228494858	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:228494858C>T	ENST00000570156.2	+	56	15128	c.15054C>T	c.(15052-15054)ctC>ctT	p.L5018L	OBSCN_ENST00000366707.4_Silent_p.L1695L|OBSCN_ENST00000422127.1_Silent_p.L4061L|OBSCN_ENST00000284548.11_Silent_p.L4061L|OBSCN_ENST00000366709.4_Silent_p.L1180L	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	4061					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				TGGCCAGCCTCTCTGTCCGTG	0.632000													14	75					0	0	0.000422831	0	0
DNAH8	1769	broad.mit.edu	37	6	38830135	38830135	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:38830135G>A	ENST00000359357.3	+	42	5814	c.5560G>A	c.(5560-5562)Gaa>Aaa	p.E1854K	DNAH8_ENST00000449981.2_Missense_Mutation_p.E2071K|DNAH8_ENST00000441566.1_Missense_Mutation_p.E1854K					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TGGCAAAACAGAAACCACAAA	0.463000													35	67					0	0	0.000814825	0	0
TADA3	10474	broad.mit.edu	37	3	9827025	9827025	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:9827025G>A	ENST00000343450.2	-	7	1442	c.895C>T	c.(895-897)Cct>Tct	p.P299S	TADA3_ENST00000440161.1_Missense_Mutation_p.P299S|TADA3_ENST00000301964.2_Missense_Mutation_p.P299S	NM_133480.1	NP_597814.1	O75528	TADA3_HUMAN	transcriptional adaptor 3	299					estrogen receptor signaling pathway|histone H3 acetylation|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	ligand-dependent nuclear receptor binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(4)|skin(2)|upper_aerodigestive_tract(1)	16						TGATTGCGAGGGGAGGTGCTT	0.517000													19	39					0	0	0.00229938	0	0
RIMS2	9699	broad.mit.edu	37	8	104897590	104897590	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:104897590G>A	ENST00000507740.1	+	2	423	c.187G>A	c.(187-189)Gaa>Aaa	p.E63K	RIMS2_ENST00000262231.10_Missense_Mutation_p.E63K|RIMS2_ENST00000522174.1_3'UTR|RIMS2_ENST00000406091.3_Missense_Mutation_p.E255K|RIMS2_ENST00000436393.2_Missense_Mutation_p.E33K	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	286	RabBD.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AGAAAGAGAGGAATATTCACA	0.413000										HNSCC(12;0.0054)			12	23					0	0	0.00185496	0	0
SYT11	23208	broad.mit.edu	37	1	155838375	155838375	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:155838375C>T	ENST00000368324.4	+	2	907	c.654C>T	c.(652-654)acC>acT	p.T218T	SYT11_ENST00000539162.1_Intron	NM_152280.4	NP_689493.3	Q9BT88	SYT11_HUMAN	synaptotagmin XI	218	C2 1.					cell junction|synaptic vesicle membrane	protein binding|transporter activity			breast(2)|central_nervous_system(1)|endometrium(1)|lung(12)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;0.000162)			TGCGGAAGACCCTGGACCCTG	0.557000													12	49					0	0	0.000978159	0	0
CD19	930	broad.mit.edu	37	16	28950019	28950019	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:28950019G>A	ENST00000538922.1	+	13	1574	c.1512G>A	c.(1510-1512)atG>atA	p.M504I	CD19_ENST00000567541.1_Missense_Mutation_p.M504I|CD19_ENST00000324662.3_Missense_Mutation_p.M503I	NM_001178098.1|NM_001770.5	NP_001171569.1|NP_001761.3	P15391	CD19_HUMAN	CD19 molecule	503					cellular defense response	external side of plasma membrane|integral to plasma membrane	protein binding|receptor signaling protein activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|ovary(2)|skin(4)|urinary_tract(1)	29						ATGAGGATATGAGAGGAATCC	0.607000													16	41					0	0	0.00121646	0	0
DGKK	139189	broad.mit.edu	37	X	50119821	50119821	+	RNA	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:50119821G>A	ENST00000376025.2	-	0	3266							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					TCGTCAGAGAGGCTCTCTTGA	0.502000													9	24					0	0	0.000978159	0	0
TRAPPC11	60684	broad.mit.edu	37	4	184589218	184589218	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:184589218A>G	ENST00000334690.6	+	5	710	c.508A>G	c.(508-510)Aag>Gag	p.K170E	TRAPPC11_ENST00000357207.4_Missense_Mutation_p.K170E|TRAPPC11_ENST00000511409.1_3'UTR	NM_021942.5	NP_068761.4	Q7Z392	CD041_HUMAN	trafficking protein particle complex 11	170																	ACTCTCAGGAAAGTCTTTGTT	0.358000													55	116					0	0	0.000781405	0	0
TUBB2A	7280	broad.mit.edu	37	6	3155866	3155866	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:3155866G>A	ENST00000333628.3	-	3	332	c.270C>T	c.(268-270)ttC>ttT	p.F90F	TUBB2A_ENST00000489942.1_5'UTR	NM_001069.2	NP_001060.1	Q13885	TBB2A_HUMAN	tubulin, beta 2A class IIa	90					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			endometrium(2)|large_intestine(4)|lung(2)|skin(1)	9	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				TACCGAACACGAAGTTGTCTG	0.517000													10	32					0	0	0.00136819	0	0
OR2T2	401992	broad.mit.edu	37	1	248616173	248616173	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:248616173C>T	ENST00000342927.3	+	1	97	c.75C>T	c.(73-75)ccC>ccT	p.P25P		NM_001004136.1	NP_001004136.1	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T, member 2	25					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(21)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)	37	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGCCTTCCCCGGGCTTCTCT	0.537000													44	304					0	0	0.000781405	0	0
HVCN1	84329	broad.mit.edu	37	12	111089247	111089247	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:111089247G>A	ENST00000356742.5	-	5	1171	c.418C>T	c.(418-420)Cac>Tac	p.H140Y	HVCN1_ENST00000439744.2_Missense_Mutation_p.H120Y|HVCN1_ENST00000242607.8_Missense_Mutation_p.H140Y|HVCN1_ENST00000548312.1_Missense_Mutation_p.H140Y			Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	140					response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	19						CTCATGTAGTGGAATACCTGA	0.478000													10	15					0	0	0.000442599	0	0
NPBWR2	2832	broad.mit.edu	37	20	62737683	62737683	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:62737683G>A	ENST00000369768.1	-	1	841	c.502C>T	c.(502-504)Ctg>Ttg	p.L168L		NM_005286.2	NP_005277.2	P48146	NPBW2_HUMAN	neuropeptides B/W receptor 2	168						plasma membrane	opioid receptor activity|protein binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(38;2.58e-11)|all_epithelial(29;6.4e-13)|Lung NSC(23;1.25e-09)|all_lung(23;4.21e-09)					CAGACACACAGGCTGGCGACC	0.652000													7	26					0	0	0.000442599	0	0
WDR90	197335	broad.mit.edu	37	16	706315	706315	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:706315C>T	ENST00000549091.1	+	18	2072	c.1980C>T	c.(1978-1980)ccC>ccT	p.P660P	WDR90_ENST00000293879.4_Silent_p.P660P	NM_145294.4	NP_660337.3	Q96KV7	WDR90_HUMAN	WD repeat domain 90	660										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				ACGAGGGCCCCGTCAGCTCAG	0.697000													5	16					0	0	0.00116845	0	0
HERC2P3	283755	broad.mit.edu	37	15	20645838	20645838	+	RNA	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:20645838G>A	ENST00000428453.1	-	0	2927																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						GCGTGAGAGCGATGCTCTGCA	0.612000													11	12					0	0	0.000978159	0	0
PNLIPRP1	5407	broad.mit.edu	37	10	118365033	118365033	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:118365033G>A	ENST00000528052.1	+	12	1379	c.1308G>A	c.(1306-1308)aaG>aaA	p.K436K	PNLIPRP1_ENST00000358834.4_Silent_p.K436K|PNLIPRP1_ENST00000534537.1_Silent_p.K436K			P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1	436	PLAT.				lipid metabolic process		calcium ion binding|triglyceride lipase activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	38				all cancers(201;0.0161)		GTGCCACCAAGATCACTGTGC	0.413000													10	22					0	0	0.000978159	0	0
MTOR	2475	broad.mit.edu	37	1	11303281	11303281	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:11303281G>A	ENST00000361445.4	-	9	1378	c.1302C>T	c.(1300-1302)ttC>ttT	p.F434F		NM_004958.3	NP_004949.1	P42345	MTOR_HUMAN	mechanistic target of rapamycin (serine/threonine kinase)	434					cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(7)|endometrium(20)|kidney(34)|large_intestine(21)|lung(43)|ovary(9)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	149						CCAGGGCTTGGAAGGCCGCTG	0.522000													21	58					0	0	0.00152264	0	0
RGS21	431704	broad.mit.edu	37	1	192335163	192335163	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:192335163C>T	ENST00000417209.2	+	5	542	c.368C>T	c.(367-369)tCt>tTt	p.S123F		NM_001039152.3	NP_001034241.1	Q2M5E4	RGS21_HUMAN	regulator of G-protein signaling 21	123	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			NS(1)|endometrium(3)|large_intestine(4)|lung(5)|ovary(1)|skin(1)	15						GCCAAGGATTCTTTCCCTCGA	0.378000													23	110					0	0	0.00047179	0	0
C6orf165	154313	broad.mit.edu	37	6	88173827	88173827	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:88173827G>A	ENST00000507897.1	+	13	1811	c.1728G>A	c.(1726-1728)aaG>aaA	p.K576K	C6orf165_ENST00000506888.1_3'UTR|C6ORF165_ENST00000369562.4_Silent_p.K576K			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	576										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		ACCCTCCAAAGGACACTAGCA	0.478000													15	27					0	0	0.000308642	0	0
MUC16	94025	broad.mit.edu	37	19	9068414	9068414	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:9068414G>A	ENST00000397910.4	-	3	19235	c.19032C>T	c.(19030-19032)tcC>tcT	p.S6344S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6346	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCATTGATGTGGAAACTATTG	0.438000													14	38					0	0	0.00185496	0	0
ACTN2	88	broad.mit.edu	37	1	236914939	236914939	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:236914939C>T	ENST00000366578.4	+	15	1992	c.1826C>T	c.(1825-1827)aCc>aTc	p.T609I	ACTN2_ENST00000542672.1_Missense_Mutation_p.T609I|ACTN2_ENST00000546208.1_Missense_Mutation_p.T103I	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	609					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GAGCTCCGGACCAAGTGGGAC	0.567000													9	51					0	0	0.000978159	0	0
NPY5R	4889	broad.mit.edu	37	4	164272238	164272238	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:164272238C>T	ENST00000515560.1	+	4	2335	c.813C>T	c.(811-813)ctC>ctT	p.L271L	NPY5R_ENST00000338566.3_Silent_p.L271L|NPY5R_ENST00000506953.1_Silent_p.L271L			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	271					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				AGGTGAAACTCTCTGGCAGCC	0.398000													19	69					0	0	0.00152264	0	0
SCN11A	11280	broad.mit.edu	37	3	38938447	38938447	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:38938447G>A	ENST00000450244.1	-	14	2490	c.2292C>T	c.(2290-2292)atC>atT	p.I764I	SCN11A_ENST00000444237.2_Silent_p.I764I|SCN11A_ENST00000302328.3_Silent_p.I764I|SCN11A_ENST00000456224.3_Silent_p.I764I			Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	764					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	CCCCGCAGAGGATGCGGAATA	0.473000													10	32					0	0	0.000673444	0	0
CHEK2P2	646096	broad.mit.edu	37	15	20495446	20495446	+	RNA	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:20495446G>A	ENST00000555186.1	+	0	649					NR_038836.1																						TTCTAGCCCAGGTATTCGTAT	0.383000													9	64					0	0	0.000442599	0	0
PGLYRP4	57115	broad.mit.edu	37	1	153309673	153309673	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:153309673G>A	ENST00000368739.3	-	8	1273	c.915C>T	c.(913-915)ttC>ttT	p.F305F	PGLYRP4_ENST00000359650.5_Silent_p.F309F			Q96LB8	PGRP4_HUMAN	peptidoglycan recognition protein 4	309					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(4)|lung(10)|ovary(3)|prostate(1)|skin(1)|stomach(1)	23	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			AGGTGCCCATGAAGGTAATGC	0.522000													16	71					0	0	0.000958276	0	0
TBX19	9095	broad.mit.edu	37	1	168260534	168260534	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:168260534C>T	ENST00000367821.3	+	2	391	c.340C>T	c.(340-342)Cca>Tca	p.P114S		NM_005149.2	NP_005140.1	O60806	TBX19_HUMAN	T-box 19	114					anatomical structure morphogenesis	nucleus	DNA binding			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(11)|prostate(2)|skin(2)|urinary_tract(1)	34	all_hematologic(923;0.215)					CGCTGGCAAGCCAGAGGTCTC	0.587000													22	103					0	0	0.00106085	0	0
GPRC5A	9052	broad.mit.edu	37	12	13061445	13061445	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:13061445G>A	ENST00000014914.5	+	2	1152	c.262G>A	c.(262-264)Gga>Aga	p.G88R	GPRC5A_ENST00000542056.1_Intron	NM_003979.3	NP_003970.1	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5, member A	88						cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	18		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	CTTCATCATCGGACTGGACGG	0.552000													54	134					0	0	0.000781405	0	0
TNS1	7145	broad.mit.edu	37	2	218669216	218669216	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:218669216G>A	ENST00000171887.4	-	33	5626	c.5174C>T	c.(5173-5175)tCc>tTc	p.S1725F	TNS1_ENST00000430930.1_Missense_Mutation_p.S1704F|TNS1_ENST00000419504.1_Missense_Mutation_p.S1711F	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	1725						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		CATGACCTTGGAGACGAAGTT	0.627000													28	84					0	0	0.000692331	0	0
BCL11A	53335	broad.mit.edu	37	2	60688028	60688028	+	Silent	SNP	G	G	A	rs115953983	by1000genomes	TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:60688028G>A	ENST00000335712.6	-	4	2246	c.2019C>T	c.(2017-2019)ttC>ttT	p.F673F	BCL11A_ENST00000537768.1_Silent_p.F342F|BCL11A_ENST00000358510.4_Silent_p.F639F|BCL11A_ENST00000538214.1_Silent_p.F639F|BCL11A_ENST00000356842.4_Silent_p.F673F|BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000359629.5_Intron	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	673					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			CGAAGCTAAGGAAGGGATCTT	0.642000			T	IGH@	B-CLL								145	326					0	0	0.000781405	0	0
NID1	4811	broad.mit.edu	37	1	236175286	236175286	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:236175286G>A	ENST00000264187.6	-	12	2544	c.2462C>T	c.(2461-2463)cCa>cTa	p.P821L	NID1_ENST00000366595.3_Intron	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	821	EGF-like 5; calcium-binding (Potential).				cell-matrix adhesion	basement membrane	calcium ion binding			breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GAAAGAGCCTGGAGTGTTGTA	0.552000													20	45					0	0	0.00229938	0	0
UBXN4	23190	broad.mit.edu	37	2	136505928	136505928	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:136505928C>T	ENST00000272638.9	+	2	485	c.174C>T	c.(172-174)atC>atT	p.I58I		NM_014607.3	NP_055422.1	Q92575	UBXN4_HUMAN	UBX domain protein 4	58					response to unfolded protein	endoplasmic reticulum membrane|nuclear envelope	protein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	24						CTATTAAAATCGATACCAAAA	0.289000													7	34					0	0	0.00198382	0	0
WFDC8	90199	broad.mit.edu	37	20	44181906	44181906	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:44181906C>T	ENST00000357199.4	-	5	533	c.455G>A	c.(454-456)gGa>gAa	p.G152E	WFDC8_ENST00000289953.2_Missense_Mutation_p.G152E	NM_181510.2	NP_852611.2	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8	152	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|stomach(1)|upper_aerodigestive_tract(1)	15		Myeloproliferative disorder(115;0.0122)				TGGGCATTGTCCATCCTTAAC	0.468000													9	31					0	0	0.000673444	0	0
PTPRA	5786	broad.mit.edu	37	20	2969051	2969051	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:2969051G>A	ENST00000216877.6	+	8	1042	c.642G>A	c.(640-642)gtG>gtA	p.V214V	PTPRA_ENST00000399903.2_Silent_p.V223V|PTPRA_ENST00000380393.3_Silent_p.V223V|PTPRA_ENST00000356147.3_Silent_p.V214V|PTPRA_ENST00000425918.2_Silent_p.V234V|PTPRA_ENST00000358719.4_Silent_p.V79V|PTPRA_ENST00000318266.5_Silent_p.V214V	NM_080840.2	NP_543030.1	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	223					axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						CCCTGCCCGTGGACAAGCTGG	0.527000													25	44					0	0	0.000586117	0	0
PREX2	80243	broad.mit.edu	37	8	69129915	69129915	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:69129915C>T	ENST00000288368.4	+	38	4946	c.4669C>T	c.(4669-4671)Cgt>Tgt	p.R1557C		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	1557					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity	p.R1557C(1)		NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						ACTGCCACCTCGTTACATCAT	0.552000													9	17					0	0	0.000673444	0	0
DNAH8	1769	broad.mit.edu	37	6	38854607	38854607	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:38854607G>A	ENST00000359357.3	+	55	7903	c.7649G>A	c.(7648-7650)gGa>gAa	p.G2550E	DNAH8_ENST00000449981.2_Missense_Mutation_p.G2767E|DNAH8_ENST00000441566.1_Missense_Mutation_p.G2514E					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GAAATGGAAGGAATGTACAGC	0.398000													12	55					0	0	0.00185496	0	0
SETDB1	9869	broad.mit.edu	37	1	150902529	150902529	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:150902529C>T	ENST00000271640.5	+	3	537	c.347C>T	c.(346-348)tCt>tTt	p.S116F	SETDB1_ENST00000368969.4_Missense_Mutation_p.S116F|SETDB1_ENST00000368963.1_Missense_Mutation_p.S116F|SETDB1_ENST00000368962.2_Missense_Mutation_p.S116F|SETDB1_ENST00000459773.1_3'UTR	NM_001145415.1|NM_012432.3	NP_001138887.1|NP_036564.3	Q15047	SETB1_HUMAN	SET domain, bifurcated 1	116					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|Golgi apparatus|nucleus|plasma membrane	DNA binding|histone-lysine N-methyltransferase activity|protein binding|zinc ion binding			NS(1)|large_intestine(5)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|BRCA - Breast invasive adenocarcinoma(12;0.0152)|LUSC - Lung squamous cell carcinoma(543;0.211)			GAGGACGAATCTTCCCGGCCT	0.448000													17	80					0	0	0.00074312	0	0
DNAH10	196385	broad.mit.edu	37	12	124403268	124403268	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:124403268G>A	ENST00000409039.3	+	64	10949	c.10924G>A	c.(10924-10926)Gac>Aac	p.D3642N		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	3642					microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTTGGACATCGACAGGCTGCG	0.577000													9	19					0	0	0.000673444	0	0
SNRPC	6631	broad.mit.edu	37	6	34741275	34741275	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:34741275C>T	ENST00000374017.3	+	5	758	c.471C>T	c.(469-471)ccC>ccT	p.P157P	SNRPC_ENST00000474635.1_3'UTR|SNRPC_ENST00000374018.1_Silent_p.P95P|SNRPC_ENST00000244520.5_Silent_p.P136P			P09234	RU1C_HUMAN	small nuclear ribonucleoprotein polypeptide C	136					spliceosomal snRNP assembly	Cajal body|U1 snRNP	protein homodimerization activity|single-stranded RNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|pancreas(1)	6						TGCCTGGGCCCCCAATGATGA	0.552000													17	43					0	0	0.000566183	0	0
KCNJ1	3758	broad.mit.edu	37	11	128709568	128709568	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:128709568G>A	ENST00000392665.2	-	2	715	c.571C>T	c.(571-573)Cta>Tta	p.L191L	KCNJ1_ENST00000324036.3_Silent_p.L191L|KCNJ1_ENST00000440599.2_Silent_p.L191L|KCNJ1_ENST00000392664.2_Silent_p.L210L|KCNJ1_ENST00000392666.1_Silent_p.L191L	NM_153764.2	NP_722448.1	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 1	210					excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			breast(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)	23	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	ACTCGGATTAGGAGGCAAAGC	0.488000													25	96					0	0	0.00278032	0	0
COL25A1	84570	broad.mit.edu	37	4	109895523	109895523	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:109895523C>T	ENST00000399132.1	-	8	1022	c.492_splice	c.e8+1	p.R164_splice	COL25A1_ENST00000399126.1_Splice_Site_p.R164_splice|COL25A1_ENST00000399127.1_Splice_Site_p.R164_splice	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	164	Collagen-like 1.					collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		CACAACTTACCCTAGGTCCCT	0.378000													24	42					0	0	0.00047179	0	0
TJP2	9414	broad.mit.edu	37	9	71849418	71849418	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:71849418C>T	ENST00000377245.4	+	12	1943	c.1735C>T	c.(1735-1737)Cct>Tct	p.P579S	TJP2_ENST00000453658.2_Missense_Mutation_p.P556S|TJP2_ENST00000265384.7_Missense_Mutation_p.P579S|TJP2_ENST00000539225.1_Missense_Mutation_p.P610S|TJP2_ENST00000348208.4_Missense_Mutation_p.P579S|TJP2_ENST00000535702.1_Missense_Mutation_p.P583S	NM_004817.3	NP_004808.2	Q9UDY2	ZO2_HUMAN	tight junction protein 2	579	PDZ 3.				cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(5)|lung(9)|prostate(3)|skin(3)|soft_tissue(1)|upper_aerodigestive_tract(1)	35						GTTAGAAATCCCTAAAGGTGA	0.443000													26	35					0	0	0.00178596	0	0
UGT2B7	7364	broad.mit.edu	37	4	69973826	69973826	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:69973826C>T	ENST00000305231.7	+	5	1142	c.1096C>T	c.(1096-1098)Cca>Tca	p.P366S	UGT2B7_ENST00000508661.1_Intron|UGT2B7_ENST00000509763.1_Intron	NM_001074.2	NP_001065.2	P16662	UD2B7_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B7	366					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						CCTAGGTCATCCAAAGACCAG	0.418000													31	72					0	0	0.00178596	0	0
LRBA	987	broad.mit.edu	37	4	151388908	151388908	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:151388908G>A	ENST00000535741.1	-	44	7170	c.6697C>T	c.(6697-6699)Cca>Tca	p.P2233S	LRBA_ENST00000507224.1_Missense_Mutation_p.P2233S|LRBA_ENST00000510413.1_Missense_Mutation_p.P2233S|LRBA_ENST00000503716.1_5'UTR|LRBA_ENST00000357115.3_Missense_Mutation_p.P2244S			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	2244	BEACH.					endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					GGAAACACTGGATACTGATTT	0.323000													19	58					0	0	0.00188189	0	0
SSH1	54434	broad.mit.edu	37	12	109186493	109186493	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:109186493G>A	ENST00000326495.5	-	14	1555	c.1462C>T	c.(1462-1464)Ccg>Tcg	p.P488S	SSH1_ENST00000360239.3_Missense_Mutation_p.P176S|SSH1_ENST00000326470.5_Missense_Mutation_p.P499S|SSH1_ENST00000551165.1_Missense_Mutation_p.P488S	NM_018984.3	NP_061857.3	Q8WYL5	SSH1_HUMAN	slingshot protein phosphatase 1	488					actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TGGCTTTCCGGGGTGCCATCT	0.647000													20	44					0	0	0.00152264	0	0
SSPO	23145	broad.mit.edu	37	7	149480322	149480322	+	RNA	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:149480322C>T	ENST00000378016.2	+	0	2204							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GGAAGATGCCCCTCTGAGGAC	0.617000													5	48					0	0	0.000157383	0	0
P2RY2	5029	broad.mit.edu	37	11	72946179	72946179	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:72946179C>T	ENST00000311131.2	+	3	1442	c.975C>T	c.(973-975)ggC>ggT	p.G325G	P2RY2_ENST00000393596.2_Silent_p.G325G|P2RY2_ENST00000393597.2_Silent_p.G325G	NM_002564.2|NM_176072.1	NP_002555.2|NP_788086.1	P41231	P2RY2_HUMAN	purinergic receptor P2Y, G-protein coupled, 2	325					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25					Suramin(DB04786)	CACCCACTGGCCCCAGCCCTG	0.642000													7	28					0	0	0.000274275	0	0
IGHV1OR21-1	390530	broad.mit.edu	37	21	10863024	10863024	+	RNA	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr21:10863024C>T	ENST00000559480.1	+	0	320																				breast(1)|endometrium(1)|kidney(3)|lung(20)|urinary_tract(1)	26						AGTCTGAGATCTGAGGACACG	0.507000													47	327					0	0	0.000781405	0	0
PKHD1	5314	broad.mit.edu	37	6	51524233	51524233	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:51524233G>A	ENST00000371117.3	-	61	10966	c.10691C>T	c.(10690-10692)gCc>gTc	p.A3564V		NM_138694.3	NP_619639.3	P08F94	PKHD1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)	3564					cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					CACAGTGAGGGCCAAGTGAAT	0.408000													13	53					0	0	0.00136819	0	0
ZFP64	55734	broad.mit.edu	37	20	50769728	50769728	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:50769728G>A	ENST00000216923.4	-	6	1352	c.1003C>T	c.(1003-1005)Cgc>Tgc	p.R335C	ZFP64_ENST00000371518.2_Intron|ZFP64_ENST00000361387.2_Intron|ZFP64_ENST00000477786.1_Intron|ZFP64_ENST00000371515.4_Missense_Mutation_p.R333C|ZFP64_ENST00000346617.4_Missense_Mutation_p.R281C	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	335					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						TGGTGCACGCGGCTGTGCTTC	0.592000													31	64					0	0	0.00209593	0	0
OR2G3	81469	broad.mit.edu	37	1	247769793	247769793	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:247769793G>A	ENST00000320002.2	+	1	938	c.906G>A	c.(904-906)agG>agA	p.R302R	RP11-978I15.10_ENST00000435333.1_RNA|RP11-978I15.10_ENST00000446347.1_RNA	NM_001001914.1	NP_001001914.1	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G, member 3	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(1)|lung(31)|skin(5)	50	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			AGGCTCTGAGGAAACTTCTCT	0.393000													34	62					0	0	0.000953801	0	0
ZNF185	7739	broad.mit.edu	37	X	152128332	152128332	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:152128332G>A	ENST00000535861.1	+	18	1640	c.1592G>A	c.(1591-1593)gGa>gAa	p.G531E	ZNF185_ENST00000324823.6_Missense_Mutation_p.G267E|ZNF185_ENST00000318529.8_Missense_Mutation_p.G278E|ZNF185_ENST00000539731.1_Missense_Mutation_p.G502E|ZNF185_ENST00000370270.1_Missense_Mutation_p.G262E|ZNF185_ENST00000318504.7_Missense_Mutation_p.G440E|ZNF185_ENST00000370268.4_Missense_Mutation_p.G499E|ZNF185_ENST00000449285.2_Missense_Mutation_p.G500E	NM_001178106.1	NP_001171577.1	O15231	ZN185_HUMAN	zinc finger protein 185 (LIM domain)	499						cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			NS(1)|endometrium(1)|kidney(2)|large_intestine(2)|lung(3)|ovary(3)	12	Acute lymphoblastic leukemia(192;6.56e-05)					GGTGGCCAAGGAGACCCAGCT	0.592000													5	24					0	0	0.000602214	0	0
ASPHD1	253982	broad.mit.edu	37	16	29912596	29912596	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:29912596G>A	ENST00000308748.5	+	1	556	c.304G>A	c.(304-306)Gac>Aac	p.D102N	ASPHD1_ENST00000483405.1_Intron	NM_181718.3	NP_859069.2	Q5U4P2	ASPH1_HUMAN	aspartate beta-hydroxylase domain containing 1	102					peptidyl-amino acid modification	integral to endoplasmic reticulum membrane	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity			endometrium(4)|large_intestine(2)|lung(1)|prostate(1)	8						GGGCTCCCAAGACATGCAGGC	0.701000													20	61					0	0	0.00047179	0	0
HMBOX1	79618	broad.mit.edu	37	8	28876343	28876343	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:28876343C>T	ENST00000397358.3	+	7	1468	c.764C>T	c.(763-765)cCc>cTc	p.P255L	HMBOX1_ENST00000444075.1_Missense_Mutation_p.P255L|HMBOX1_ENST00000519047.1_Missense_Mutation_p.P255L|HMBOX1_ENST00000523613.1_Missense_Mutation_p.P255L|HMBOX1_ENST00000403668.2_Missense_Mutation_p.P255L|HMBOX1_ENST00000287701.10_Missense_Mutation_p.P255L|HMBOX1_ENST00000558662.1_Missense_Mutation_p.P255L|HMBOX1_ENST00000355231.5_Missense_Mutation_p.P255L|HMBOX1_ENST00000524238.1_Missense_Mutation_p.P255L	NM_024567.3	NP_078843.2	Q6NT76	HMBX1_HUMAN	homeobox containing 1	255					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)	11		Ovarian(32;0.0192)		KIRC - Kidney renal clear cell carcinoma(542;0.135)|Kidney(114;0.161)		CAAACGCCTCCCCCAGTCTCT	0.488000													25	51					0	0	0.000720815	0	0
AMICA1	120425	broad.mit.edu	37	11	118076638	118076638	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:118076638C>T	ENST00000292067.7	-	4	904	c.463G>A	c.(463-465)Gtg>Atg	p.V155M	AMICA1_ENST00000533261.1_Missense_Mutation_p.V165M|AMICA1_ENST00000526620.1_Missense_Mutation_p.V126M|AMICA1_ENST00000356289.5_Missense_Mutation_p.V165M	NM_153206.2	NP_694938.2	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen 1	165	Ig-like V-type 2.				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				central_nervous_system(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(1)|stomach(2)	20	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		ACCTTGGTCACGTGTTTCACT	0.458000													35	98					0	0	0.00195071	0	0
TNS1	7145	broad.mit.edu	37	2	218669215	218669215	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:218669215G>A	ENST00000171887.4	-	33	5627	c.5175C>T	c.(5173-5175)tcC>tcT	p.S1725S	TNS1_ENST00000430930.1_Silent_p.S1704S|TNS1_ENST00000419504.1_Silent_p.S1711S	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	1725						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GCATGACCTTGGAGACGAAGT	0.627000													28	84					0	0	0.00058488	0	0
CCDC71	64925	broad.mit.edu	37	3	49200301	49200301	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:49200301G>A	ENST00000321895.6	-	2	1447	c.1341C>T	c.(1339-1341)atC>atT	p.I447I		NM_022903.3	NP_075054.3	Q8IV32	CCD71_HUMAN	coiled-coil domain containing 71	447										endometrium(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)	10				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00217)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCACGCGGAGGATCCGCTGAG	0.557000													6	17					0	0	0.00198382	0	0
ARHGEF2	9181	broad.mit.edu	37	1	155931590	155931590	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:155931590C>T	ENST00000368316.1	-	15	1716	c.1246G>A	c.(1246-1248)Gag>Aag	p.E416K	ARHGEF2_ENST00000313667.4_Missense_Mutation_p.E443K|ARHGEF2_ENST00000368315.3_Missense_Mutation_p.E445K|ARHGEF2_ENST00000313695.7_Missense_Mutation_p.E416K|ARHGEF2_ENST00000361247.4_Missense_Mutation_p.E444K			Q92974	ARHG2_HUMAN	Rho/Rac guanine nucleotide exchange factor (GEF) 2	444	DH.				actin filament organization|apoptosis|cell division|cell morphogenesis|induction of apoptosis by extracellular signals|intracellular protein transport|mitosis|negative regulation of microtubule depolymerization|nerve growth factor receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|regulation of cell proliferation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|Golgi apparatus|microtubule|ruffle membrane|spindle|tight junction	microtubule binding|Rac GTPase binding|Rac guanyl-nucleotide exchange factor activity|zinc ion binding			breast(4)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|skin(2)	40	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					TTGTAGATCTCCTGCAGACGG	0.607000													24	93					0	0	0.00047179	0	0
LRP5	4041	broad.mit.edu	37	11	68153959	68153959	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:68153959C>T	ENST00000294304.7	+	6	1297	c.1191C>T	c.(1189-1191)atC>atT	p.I397I		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	397	Beta-propeller 2.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TGCGGGCCATCCGCAGGGCGT	0.637000													8	44					0	0	0.000157383	0	0
MAP4	4134	broad.mit.edu	37	3	47951734	47951734	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:47951734G>A	ENST00000426837.2	-	10	4315	c.4228C>T	c.(4228-4230)Ccc>Tcc	p.P1410S	MAP4_ENST00000395734.3_Intron|MAP4_ENST00000383737.4_Intron|MAP4_ENST00000360240.6_Intron			P27816	MAP4_HUMAN	microtubule-associated protein 4	897					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(2)|pancreas(1)|skin(2)	32				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		GTTTCCATGGGAACATGTATT	0.373000													5	25					0	0	0.00116845	0	0
ZZEF1	23140	broad.mit.edu	37	17	3919720	3919720	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:3919720A>C	ENST00000381638.2	-	49	8166	c.8042T>G	c.(8041-8043)cTg>cGg	p.L2681R		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	2681							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						CATGGTCCCCAGCATGTCCTC	0.567000													9	42					0	0	0.000442599	0	0
ACTN2	88	broad.mit.edu	37	1	236923026	236923026	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:236923026G>A	ENST00000366578.4	+	19	2470	c.2304G>A	c.(2302-2304)agG>agA	p.R768R	ACTN2_ENST00000542672.1_Silent_p.R768R|ACTN2_ENST00000546208.1_Silent_p.R262R	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	768	EF-hand 1.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			GCCAACAGAGGAAGAATGGCC	0.433000													40	56					0	0	0.000680045	0	0
HGF	3082	broad.mit.edu	37	7	81392041	81392041	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:81392041C>T	ENST00000222390.5	-	2	462	c.236G>A	c.(235-237)gGa>gAa	p.G79E	HGF_ENST00000354224.6_Missense_Mutation_p.G79E|HGF_ENST00000444829.2_Missense_Mutation_p.G79E|HGF_ENST00000453018.1_5'UTR|HGF_ENST00000423064.2_Missense_Mutation_p.G79E|HGF_ENST00000457544.2_Missense_Mutation_p.G79E|HGF_ENST00000453411.1_Missense_Mutation_p.G79E	NM_000601.4	NP_000592.3	P14210	HGF_HUMAN	hepatocyte growth factor (hepapoietin A; scatter factor)	79	PAN.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(41)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	75						GAATGGAAGTCCTTTATTCCT	0.323000													23	111					0	0	0.000878237	0	0
KCTD19	146212	broad.mit.edu	37	16	67327935	67327935	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:67327935C>T	ENST00000304372.5	-	12	1785	c.1730G>A	c.(1729-1731)cGa>cAa	p.R577Q		NM_001100915.1	NP_001094385.1	Q17RG1	KCD19_HUMAN	potassium channel tetramerization domain containing 19	577						voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(3)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(3)	23		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		CTTGGCATTTCGGCATAGGGA	0.582000													59	104					0	0	0.000781405	0	0
PARD3	56288	broad.mit.edu	37	10	34400331	34400331	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:34400331G>A	ENST00000374789.3	-	25	4162	c.3837C>T	c.(3835-3837)gtC>gtT	p.V1279V	PARD3_ENST00000350537.4_Silent_p.V1233V|PARD3_ENST00000545693.1_Silent_p.V1263V|PARD3_ENST00000374788.3_Silent_p.V1276V|PARD3_ENST00000545260.1_Silent_p.V1189V|PARD3_ENST00000374790.3_Silent_p.V1219V|PARD3_ENST00000374794.3_Silent_p.V1167V|PARD3_ENST00000346874.4_Silent_p.V1242V	NM_019619.3	NP_062565.2	Q8TEW0	PARD3_HUMAN	par-3 family cell polarity regulator	1279					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	63		Breast(68;0.0707)				TTTCCAGCATGACCCTGGCGT	0.592000													14	29					0	0	0.000566183	0	0
TPTE2P6	374491	broad.mit.edu	37	13	25155795	25155795	+	RNA	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr13:25155795C>T	ENST00000453498.1	+	0	411																											cttttcttttctaggaaGAAC	0.318000													6	11					0	0	0.00116845	0	0
FBXL7	23194	broad.mit.edu	37	5	15928108	15928108	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:15928108C>T	ENST00000504595.1	+	3	718	c.237C>T	c.(235-237)tcC>tcT	p.S79S	FBXL7_ENST00000510662.1_Silent_p.S32S|FBXL7_ENST00000329673.7_Silent_p.S67S	NM_001278317.1|NM_012304.3	NP_001265246.1|NP_036436.1	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	79					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(13)|lung(33)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	60						CCTCGTCCTCCATCACCGGGG	0.657000													13	11					0	0	0.00185496	0	0
OR6S1	341799	broad.mit.edu	37	14	21109838	21109838	+	Missense_Mutation	SNP	C	C	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr14:21109838C>A	ENST00000320704.3	-	1	12	c.13G>T	c.(13-15)Ggg>Tgg	p.G5W		NM_001001968.1	NP_001001968.1	Q8NH40	OR6S1_HUMAN	olfactory receptor, family 6, subfamily S, member 1	5					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(3)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	23	all_cancers(95;0.00304)		Epithelial(56;1.23e-06)|all cancers(55;1.01e-05)	GBM - Glioblastoma multiforme(265;0.0135)		CTGTGGTTCCCATCAGGACTC	0.438000													5	70					0.00198382	0.00948867	0.00198382	1	0
PTPRO	5800	broad.mit.edu	37	12	15661550	15661550	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:15661550A>C	ENST00000281171.4	+	7	1643	c.1313A>C	c.(1312-1314)cAc>cCc	p.H438P	PTPRO_ENST00000543886.1_Missense_Mutation_p.H438P|PTPRO_ENST00000348962.2_Missense_Mutation_p.H438P	NM_030667.2	NP_109592.1	Q16827	PTPRO_HUMAN	protein tyrosine phosphatase, receptor type, O	438	Fibronectin type-III 5.					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				AAGCCGCAGCACGTGAGTGTC	0.502000													14	25					0	0	0.000422831	0	0
MUC16	94025	broad.mit.edu	37	19	9047932	9047932	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:9047932C>T	ENST00000397910.4	-	5	33902	c.33699G>A	c.(33697-33699)gaG>gaA	p.E11233E		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	11235	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGTCTATGGTCTCTGGTTGAC	0.483000													10	20					0	0	0.000442599	0	0
PAPPA2	60676	broad.mit.edu	37	1	176758969	176758969	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:176758969G>A	ENST00000367662.3	+	18	5904	c.4740G>A	c.(4738-4740)ctG>ctA	p.L1580L		NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	1580	Sushi 3.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TACAATGCCTGGAAGGTGGAA	0.448000													18	7					0	0	0.000566183	0	0
BLK	640	broad.mit.edu	37	8	11412309	11412309	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:11412309A>G	ENST00000259089.4	+	7	1122	c.530A>G	c.(529-531)tAt>tGt	p.Y177C	BLK_ENST00000529894.1_Missense_Mutation_p.Y106C	NM_001715.2	NP_001706.2	P51451	BLK_HUMAN	B lymphoid tyrosine kinase	177	SH2.				intracellular protein kinase cascade|positive regulation of insulin secretion		ATP binding|non-membrane spanning protein tyrosine kinase activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(4)|stomach(1)	27			STAD - Stomach adenocarcinoma(15;0.00391)	COAD - Colon adenocarcinoma(149;0.207)		ATCAAGCACTATAAGATCCGC	0.567000													20	43					0	0	0.00278032	0	0
SLC30A10	55532	broad.mit.edu	37	1	220089128	220089128	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:220089128C>T	ENST00000366926.3	-	4	1282	c.1121G>A	c.(1120-1122)gGa>gAa	p.G374E	SLC30A10_ENST00000484079.1_5'UTR|SLC30A10_ENST00000536446.1_Missense_Mutation_p.G129E	NM_018713.2	NP_061183.2	Q6XR72	ZNT10_HUMAN	solute carrier family 30, member 10	374					zinc ion transport	integral to membrane|plasma membrane	cation transmembrane transporter activity			NS(1)|endometrium(1)|large_intestine(1)|lung(9)|skin(1)	13				GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.209)		ATTGTGGATTCCCGCATGGTG	0.468000													71	81					0	0	0.000781405	0	0
CYLC1	1538	broad.mit.edu	37	X	83128074	83128074	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:83128074G>A	ENST00000329312.4	+	4	395	c.358G>A	c.(358-360)Gat>Aat	p.D120N		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	120					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						AAAGTCCAAAGATGAAAAAGG	0.368000													15	11					0	0	0.00244969	0	0
XIST	7503	broad.mit.edu	37	X	73072212	73072212	+	RNA	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:73072212G>A	ENST00000429829.1	-	0	376					NR_001564.2																						CCGCAGCCCCGATGGGCAAAA	0.403000													6	13					0	0	0.00116845	0	0
CDH16	1014	broad.mit.edu	37	16	66946411	66946411	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:66946411G>A	ENST00000299752.4	-	11	1548	c.1355C>T	c.(1354-1356)tCc>tTc	p.S452F	CDH16_ENST00000570262.1_Missense_Mutation_p.S372F|CDH16_ENST00000565796.1_Missense_Mutation_p.S452F|CDH16_ENST00000568632.1_Missense_Mutation_p.S355F|CDH16_ENST00000394055.3_Missense_Mutation_p.S452F	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	452					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GCTTACCTGGGAAGTGATGAA	0.577000													11	42					0	0	0.000673444	0	0
GTF3C4	9329	broad.mit.edu	37	9	135553441	135553441	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:135553441C>T	ENST00000372146.4	+	2	999	c.435C>T	c.(433-435)ttC>ttT	p.F145F	GTF3C4_ENST00000483873.2_Intron	NM_012204.2	NP_036336.2	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC, polypeptide 4, 90kDa	145					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		GTCAGACTTTCATGTTGGATA	0.483000													25	73					0	0	0.000720815	0	0
DNAH8	1769	broad.mit.edu	37	6	38875794	38875794	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:38875794G>A	ENST00000359357.3	+	62	9014	c.8760G>A	c.(8758-8760)atG>atA	p.M2920I	DNAH8_ENST00000449981.2_Missense_Mutation_p.M3137I|DNAH8_ENST00000441566.1_Missense_Mutation_p.M2884I					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TTTCAGTGATGAAGAGGGAGC	0.398000													23	63					0	0	0.00047179	0	0
FNDC7	163479	broad.mit.edu	37	1	109271474	109271474	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:109271474G>A	ENST00000370017.3	+	8	1867	c.1590G>A	c.(1588-1590)cgG>cgA	p.R530R	FNDC7_ENST00000271311.2_Silent_p.R531R	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	531	Fibronectin type-III 6.					extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		AGGCAGGACGGAGCCTGCCCA	0.562000													14	36					0	0	0.000422831	0	0
COL11A1	1301	broad.mit.edu	37	1	103461558	103461558	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:103461558G>A	ENST00000358392.2	-	27	2635	c.2318C>T	c.(2317-2319)cCc>cTc	p.P773L	COL11A1_ENST00000512756.1_Missense_Mutation_p.P645L|COL11A1_ENST00000370096.3_Missense_Mutation_p.P761L|COL11A1_ENST00000353414.4_Missense_Mutation_p.P722L	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	761	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TACTCCCCGGGGGCCCGGGTA	0.378000													31	63					0	0	0.00058488	0	0
DSP	1832	broad.mit.edu	37	6	7583542	7583542	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:7583542G>A	ENST00000379802.3	+	24	6388	c.6047G>A	c.(6046-6048)gGa>gAa	p.G2016E	DSP_ENST00000418664.2_Missense_Mutation_p.G1417E	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2016	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CGGGGTGCAGGATCTATCGCT	0.453000													18	51					0	0	0.000566183	0	0
NAV2	89797	broad.mit.edu	37	11	19955287	19955287	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:19955287G>A	ENST00000396085.1	+	7	1858	c.1497G>A	c.(1495-1497)gaG>gaA	p.E499E	NAV2_ENST00000360655.4_Silent_p.E435E|NAV2_ENST00000540292.1_Silent_p.E453E|NAV2_ENST00000396087.3_Silent_p.E522E|NAV2_ENST00000527559.2_Silent_p.E451E|NAV2_ENST00000349880.4_Silent_p.E499E	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	522						nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						aggataaggagaaaagcaagg	0.532000													7	41					0	0	0.00198382	0	0
LRRC17	10234	broad.mit.edu	37	7	102579980	102579980	+	Missense_Mutation	SNP	T	T	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:102579980T>G	ENST00000249377.4	+	3	1157	c.876T>G	c.(874-876)caT>caG	p.H292Q	FBXL13_ENST00000379306.3_Intron|FBXL13_ENST00000379308.3_Intron|FBXL13_ENST00000313221.4_Intron|LRRC17_ENST00000485478.1_3'UTR|LRRC17_ENST00000339431.4_Missense_Mutation_p.H292Q|FBXL13_ENST00000456695.1_Intron|FBXL13_ENST00000455112.2_Intron|FBXL13_ENST00000379305.3_Intron|FBXL13_ENST00000436908.1_Intron|FBXL13_ENST00000393772.2_Intron	NM_005824.2	NP_005815.2	Q8N6Y2	LRC17_HUMAN	leucine rich repeat containing 17	292					bone marrow development|negative regulation of osteoclast differentiation|ossification	extracellular space				NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|liver(2)|lung(3)|ovary(1)|prostate(1)|urinary_tract(1)	17						AAGATGTTCATGAGCTGAAGA	0.403000													34	146					0	0	0.000814825	0	0
RPRD2	23248	broad.mit.edu	37	1	150430042	150430042	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:150430042C>T	ENST00000401000.4	+	7	1136	c.1071C>T	c.(1069-1071)atC>atT	p.I357I	RPRD2_ENST00000492220.1_3'UTR|RPRD2_ENST00000369068.4_Silent_p.I383I|RPRD2_ENST00000539519.1_Silent_p.I357I			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	383							protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						GGTCAAAAATCATTGGTATGT	0.393000													55	187					0	0	0.000781405	0	0
TP53	7157	broad.mit.edu	37	17	7578263	7578263	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:7578263G>A	ENST00000420246.2	-	6	718	c.586C>T	c.(586-588)Cga>Tga	p.R196*	TP53_ENST00000455263.2_Nonsense_Mutation_p.R196*|TP53_ENST00000445888.2_Nonsense_Mutation_p.R196*|TP53_ENST00000269305.4_Nonsense_Mutation_p.R196*|TP53_ENST00000413465.2_Nonsense_Mutation_p.R196*|TP53_ENST00000574684.1_Intron|TP53_ENST00000359597.4_Nonsense_Mutation_p.R196*	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	196	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> Q (in sporadic cancers; somatic mutation).|R -> S (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R196*(167)|p.R64*(14)|p.R103*(14)|p.0?(8)|p.R196fs*51(7)|p.?(5)|p.A189_V197delAPPQHLIRV(4)|p.P191_E198>Q(3)|p.R196R(2)|p.I195fs*50(1)|p.R64fs*>27(1)|p.R103fs*51(1)|p.P191fs*6(1)|p.I195_G199delIRVEG(1)|p.P98_E105>Q(1)|p.I195fs*12(1)|p.P59_E66>Q(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CCTTCCACTCGGATAAGATGC	0.552000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			8	20					0	0	0.000442599	0	0
SRRM1	10250	broad.mit.edu	37	1	24996657	24996657	+	Silent	SNP	C	C	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:24996657C>A	ENST00000323848.9	+	15	2566	c.2251C>A	c.(2251-2253)Cga>Aga	p.R751R	SRRM1_ENST00000374389.4_Silent_p.R760R|SRRM1_ENST00000447431.2_Silent_p.R763R|SRRM1_ENST00000479034.1_3'UTR	NM_005839.3	NP_005830.2	Q8IYB3	SRRM1_HUMAN	serine/arginine repetitive matrix 1	751	Pro-rich.|Ser-rich.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nuclear matrix|nuclear speck	DNA binding|protein binding|RNA binding			breast(1)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(12)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	36		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000946)|all_lung(284;0.00125)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.19)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0422)|OV - Ovarian serous cystadenocarcinoma(117;1.01e-24)|Colorectal(126;5.95e-08)|COAD - Colon adenocarcinoma(152;3.24e-06)|GBM - Glioblastoma multiforme(114;0.000148)|BRCA - Breast invasive adenocarcinoma(304;0.00177)|KIRC - Kidney renal clear cell carcinoma(1967;0.00348)|STAD - Stomach adenocarcinoma(196;0.00483)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.138)		CTCATCCTCCCGATCTGTCTC	0.532000													6	142					0.00198382	0.00948867	0.00198382	1	0
TLE6	79816	broad.mit.edu	37	19	2987153	2987153	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:2987153G>A	ENST00000246112.4	+	7	659	c.458G>A	c.(457-459)tGg>tAg	p.W153*	TLE6_ENST00000452088.1_Nonsense_Mutation_p.W30*|TLE6_ENST00000478073.2_3'UTR	NM_001143986.1	NP_001137458.1	Q9H808	TLE6_HUMAN	transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)	30					regulation of transcription, DNA-dependent	nucleus				breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|urinary_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AAGGAGCCTTGGTTTTGGCAC	0.602000													36	48					0	0	0.00222228	0	0
CENPI	2491	broad.mit.edu	37	X	100375738	100375738	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:100375738C>T	ENST00000372927.1	+	7	929	c.652C>T	c.(652-654)Cgt>Tgt	p.R218C	CENPI_ENST00000218507.5_Missense_Mutation_p.R218C|CENPI_ENST00000372926.1_Missense_Mutation_p.R218C|CENPI_ENST00000423383.1_Missense_Mutation_p.R218C	NM_006733.2	NP_006724.2	Q92674	CENPI_HUMAN	centromere protein I	218					CenH3-containing nucleosome assembly at centromere|mitotic prometaphase	cytosol|kinetochore|nucleoplasm	protein binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(19)|prostate(1)|skin(2)	30						CAAACCATTTCGTGTGAGAAA	0.388000													12	89					0	0	0.000422831	0	0
CBFA2T3	863	broad.mit.edu	37	16	88967966	88967966	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:88967966G>A	ENST00000268679.4	-	2	646	c.250C>T	c.(250-252)Ccg>Tcg	p.P84S	CBFA2T3_ENST00000360302.2_Missense_Mutation_p.P23S|CBFA2T3_ENST00000448839.1_Intron|CBFA2T3_ENST00000436887.2_Missense_Mutation_p.P84S|CBFA2T3_ENST00000327483.5_Missense_Mutation_p.P23S	NM_005187.5	NP_005178.4	O75081	MTG16_HUMAN	core-binding factor, runt domain, alpha subunit 2; translocated to, 3	84	Mediates interaction with PDE7A (in isoform 2).|Mediates localization to the nucleus (By similarity).|Pro-rich.|Required for nucleolar targeting (in isoform 1).				cell proliferation|granulocyte differentiation	Golgi membrane|nucleolus|nucleoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(3)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	17				BRCA - Breast invasive adenocarcinoma(80;0.0275)		GCGGCAGGCGGTGGGGGCGGC	0.697000			T	RUNX1	AML								10	26					0	0	0.000978159	0	0
EFCAB3	146779	broad.mit.edu	37	17	60469297	60469297	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:60469297A>C	ENST00000450662.2	+	6	493	c.422A>C	c.(421-423)tAt>tCt	p.Y141S	EFCAB3_ENST00000305286.3_Missense_Mutation_p.Y89S	NM_001144933.1	NP_001138405.1	Q8N7B9	EFCB3_HUMAN	EF-hand calcium binding domain 3	89							calcium ion binding			cervix(1)|endometrium(2)|large_intestine(5)|lung(6)|skin(3)	17			BRCA - Breast invasive adenocarcinoma(2;2.27e-11)			CATGATGTCTATAATGAATTG	0.348000													44	84					0	0	0.000781405	0	0
PRUNE2	158471	broad.mit.edu	37	9	79325833	79325833	+	Missense_Mutation	SNP	C	C	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:79325833C>G	ENST00000428286.1	-	8	1480	c.280G>C	c.(280-282)Gga>Cga	p.G94R	PRUNE2_ENST00000376718.3_Missense_Mutation_p.G453R			Q8WUY3	PRUN2_HUMAN	prune homolog 2 (Drosophila)	453					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity			endometrium(1)|kidney(4)|large_intestine(3)|lung(7)|prostate(1)	16						GCACCTTCTCCCACGGGGCTG	0.597000													13	10					0	0	0.000308642	0	0
SLC35F5	80255	broad.mit.edu	37	2	114486999	114486999	+	Silent	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:114486999A>G	ENST00000245680.2	-	11	1482	c.1069T>C	c.(1069-1071)Ttg>Ctg	p.L357L	SLC35F5_ENST00000470204.2_5'UTR	NM_025181.2	NP_079457.2	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	357					transport	integral to membrane				endometrium(1)|kidney(4)|large_intestine(2)|lung(7)|ovary(2)|prostate(3)|skin(1)	20						GGAATATCCAACTTGTCTTCT	0.353000													6	37					0	0	0.00116845	0	0
NAALAD2	10003	broad.mit.edu	37	11	89911136	89911136	+	Missense_Mutation	SNP	G	G	A	rs150474449		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:89911136G>A	ENST00000534061.1	+	16	1939	c.1709G>A	c.(1708-1710)cGa>cAa	p.R570Q	NAALAD2_ENST00000375944.3_Intron|NAALAD2_ENST00000321955.4_Missense_Mutation_p.R537Q	NM_005467.3	NP_005458.1	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	570	NAALADase.				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(32)|pancreas(1)|prostate(3)|skin(5)|stomach(2)	59		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				GCTCAATTACGAGGAGCACTG	0.348000													12	36					0	0	0.00136819	0	0
RPS6KA2	6196	broad.mit.edu	37	6	166831811	166831811	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:166831811C>T	ENST00000510118.1	-	21	2255	c.1915G>A	c.(1915-1917)Ggg>Agg	p.G639R	RPS6KA2_ENST00000405189.3_Missense_Mutation_p.G525R|RPS6KA2_ENST00000509742.1_5'UTR|RPS6KA2_ENST00000481261.2_Missense_Mutation_p.G525R|RPS6KA2_ENST00000503859.1_Missense_Mutation_p.G622R|RPS6KA2_ENST00000265678.4_Missense_Mutation_p.G614R			Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 2	614	Protein kinase 2.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(15)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	45		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		TCGTCTGGCCCATTTGCAAAA	0.443000													18	52					0	0	0.000958276	0	0
IP6K2	51447	broad.mit.edu	37	3	48732679	48732679	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:48732679C>T	ENST00000431721.2	-	3	448	c.211G>A	c.(211-213)Ggc>Agc	p.G71S	IP6K2_ENST00000443964.1_Missense_Mutation_p.G75S|IP6K2_ENST00000417896.1_Missense_Mutation_p.G16S|IP6K2_ENST00000446860.1_Missense_Mutation_p.G74S|IP6K2_ENST00000436134.1_5'UTR|IP6K2_ENST00000449610.1_Missense_Mutation_p.G16S|IP6K2_ENST00000450045.1_Missense_Mutation_p.G70S|IP6K2_ENST00000340879.4_Missense_Mutation_p.G16S|IP6K2_ENST00000432678.2_Missense_Mutation_p.G16S|IP6K2_ENST00000453202.1_Missense_Mutation_p.G16S|IP6K2_ENST00000413298.1_Missense_Mutation_p.G16S|IP6K2_ENST00000328631.5_Missense_Mutation_p.G16S	NM_001190316.1	NP_001177245.1	Q9UHH9	IP6K2_HUMAN	inositol hexakisphosphate kinase 2	16					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity			biliary_tract(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	15						AGAAGGACGCCTTTGGCGCGG	0.662000													13	22					0	0	0.00185496	0	0
SLC6A13	6540	broad.mit.edu	37	12	344336	344336	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:344336G>A	ENST00000343164.4	-	7	803	c.751C>T	c.(751-753)Cga>Tga	p.R251*	SLC6A13_ENST00000445055.2_Nonsense_Mutation_p.R159*	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	251					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			GTCACCCCTCGAATTAACAGG	0.537000													14	21					0	0	0.00185496	0	0
TUBGCP2	10844	broad.mit.edu	37	10	135099033	135099033	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:135099033G>A	ENST00000368563.2	-	12	2178	c.1822C>T	c.(1822-1824)Ctg>Ttg	p.L608L	TUBGCP2_ENST00000368562.1_Silent_p.L201L|TUBGCP2_ENST00000543663.1_Silent_p.L636L|TUBGCP2_ENST00000417178.2_Silent_p.L478L|TUBGCP2_ENST00000252936.3_Silent_p.L608L	NM_001256617.1|NM_006659.3	NP_001243546.1|NP_006650.1	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	608					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding			breast(2)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(6)|lung(16)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	35		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		CTCAGCGCCAGCTCCGTGGGG	0.637000													6	19					0	0	0.00116845	0	0
GANC	2595	broad.mit.edu	37	15	42619626	42619626	+	Missense_Mutation	SNP	T	T	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:42619626T>A	ENST00000318010.8	+	13	1726	c.1486T>A	c.(1486-1488)Ttc>Atc	p.F496I		NM_198141.2	NP_937784.2	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	496					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		TCTTTTTGCTTTCCCTGTTTA	0.383000													46	127					0	0	0.000781405	0	0
INSL6	11172	broad.mit.edu	37	9	5164194	5164194	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:5164194C>T	ENST00000381641.3	-	2	426	c.361G>A	c.(361-363)Gga>Aga	p.G121R	INSL6_ENST00000510407.1_5'UTR	NM_007179.2	NP_009110.2	Q9Y581	INSL6_HUMAN	insulin-like 6	121						extracellular region	hormone activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(7)|lung(2)	15	all_hematologic(13;0.137)	Breast(48;0.147)|Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0128)|Lung(218;0.145)		GGTGAATATCCCTTTTTATCC	0.348000													78	29					0	0	0.000781405	0	0
KCNA6	3742	broad.mit.edu	37	12	4920466	4920466	+	Missense_Mutation	SNP	T	T	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:4920466T>G	ENST00000433855.1	+	1	2125	c.1259T>G	c.(1258-1260)aTg>aGg	p.M420R	KCNA6_ENST00000280684.3_Missense_Mutation_p.M420R	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	420						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						GTGGTTACAATGACCACGGTA	0.582000										HNSCC(72;0.22)			35	67					0	0	0.000814825	0	0
NEK4	6787	broad.mit.edu	37	3	52780790	52780790	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:52780790T>C	ENST00000233027.5	-	9	1839	c.1637A>G	c.(1636-1638)cAc>cGc	p.H546R	NEK4_ENST00000535191.1_Missense_Mutation_p.H457R|NEK4_ENST00000383721.4_Missense_Mutation_p.H500R	NM_001193533.1|NM_003157.4	NP_001180462.1|NP_003148.2	P51957	NEK4_HUMAN	NIMA-related kinase 4	546					cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(9)|lung(10)	26				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		TTCCCCTCTGTGCTCAGTCTG	0.483000													24	38					0	0	0.00106085	0	0
F2	2147	broad.mit.edu	37	11	46750326	46750326	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:46750326C>T	ENST00000311907.5	+	11	1467	c.1411C>T	c.(1411-1413)Cct>Tct	p.P471S	F2_ENST00000530231.1_Intron	NM_000506.3	NP_000497.1	P00734	THRB_HUMAN	coagulation factor II (thrombin)	471	Peptidase S1.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity	p.P471S(1)		endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(3)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)	27		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	GCTGAAGAAGCCTGTTGCCTT	0.547000													12	60					0	0	0.00185496	0	0
BAZ2B	29994	broad.mit.edu	37	2	160206398	160206398	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:160206398G>A	ENST00000392783.2	-	28	5179	c.4684C>T	c.(4684-4686)Ctt>Ttt	p.L1562F	BAZ2B_ENST00000392782.1_Missense_Mutation_p.L1526F|BAZ2B_ENST00000355831.2_Missense_Mutation_p.L1528F|BAZ2B_ENST00000343439.5_Missense_Mutation_p.L1462F	NM_013450.2	NP_038478.2	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1562					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding	p.L1562I(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(7)|liver(2)|lung(41)|ovary(3)|prostate(1)|skin(2)|soft_tissue(1)|urinary_tract(1)	82						CGTGGCAAAAGACTAAACCAT	0.448000													19	87					0	0	0.000958276	0	0
AMPD3	272	broad.mit.edu	37	11	10500204	10500204	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:10500204C>T	ENST00000396554.3	+	3	721	c.380C>T	c.(379-381)tCc>tTc	p.S127F	AMPD3_ENST00000444303.2_Intron	NM_000480.2	NP_000471.1	Q01432	AMPD3_HUMAN	adenosine monophosphate deaminase 3	118					AMP catabolic process|purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(3)|skin(1)	25				all cancers(16;1.14e-08)|Epithelial(150;2.83e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0291)		GGAGCCACTTCCCTGCCCACG	0.617000													33	51					0	0	0.000814825	0	0
POTEE	445582	broad.mit.edu	37	2	131976431	131976431	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:131976431C>T	ENST00000356920.5	+	1	550	c.456C>T	c.(454-456)gtC>gtT	p.V152V	PLEKHB2_ENST00000404460.1_Intron|PLEKHB2_ENST00000303908.3_Intron|POTEE_ENST00000358087.5_Silent_p.V152V	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	152							ATP binding										GGGGTAAAGTCCCCAGAAAGG	0.572000													22	89					0	0	0.00178596	0	0
TRPC4	7223	broad.mit.edu	37	13	38225576	38225576	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr13:38225576C>T	ENST00000379705.3	-	8	2762	c.1905G>A	c.(1903-1905)tgG>tgA	p.W635*	TRPC4_ENST00000358477.2_Nonsense_Mutation_p.W635*|TRPC4_ENST00000355779.2_Nonsense_Mutation_p.W635*|TRPC4_ENST00000379679.1_Nonsense_Mutation_p.W462*|TRPC4_ENST00000447043.1_Nonsense_Mutation_p.W635*|TRPC4_ENST00000379681.3_Nonsense_Mutation_p.W635*|TRPC4_ENST00000379673.2_Intron|TRPC4_ENST00000338947.5_Nonsense_Mutation_p.W462*|TRPC4_ENST00000426868.2_3'UTR			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	635	Binds to ITPR1, ITPR2 and ITPR3.				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		GTGCAAATTTCCATTCTATAT	0.428000													11	27					0	0	0.000978159	0	0
VPS18	57617	broad.mit.edu	37	15	41192378	41192378	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:41192378G>A	ENST00000220509.5	+	4	1701	c.1362G>A	c.(1360-1362)gaG>gaA	p.E454E	VPS18_ENST00000558474.1_Intron	NM_020857.2	NP_065908.1	Q9P253	VPS18_HUMAN	vacuolar protein sorting 18 homolog (S. cerevisiae)	454					endosome organization|lysosome organization|protein transport	HOPS complex|late endosome membrane|lysosomal membrane	metal ion binding|protein binding			autonomic_ganglia(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	28		all_cancers(109;1.35e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;9.68e-11)|all_lung(180;2.25e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;1.07e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.164)		GCTACTTTGAGGAGATTGCCC	0.622000													20	58					0	0	0.000958276	0	0
KCNJ16	3773	broad.mit.edu	37	17	68129132	68129132	+	Silent	SNP	C	C	A	rs142625269		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:68129132C>A	ENST00000585558.1	+	4	1397	c.1009C>A	c.(1009-1011)Cga>Aga	p.R337R	KCNJ16_ENST00000283936.1_Silent_p.R302R|KCNJ16_ENST00000586462.1_Silent_p.R341R|KCNJ16_ENST00000589377.1_Silent_p.R302R|KCNJ16_ENST00000392670.1_Silent_p.R302R|KCNJ16_ENST00000392671.1_Silent_p.R302R			Q9NPI9	IRK16_HUMAN	potassium inwardly-rectifying channel, subfamily J, member 16	302					synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			breast(3)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	32	Breast(10;2.96e-09)					CTATGTTCCCCGAGAAATTCT	0.393000													5	96					0.00198382	0.00948867	0.00198382	1	0
CFP	5199	broad.mit.edu	37	X	47487668	47487668	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:47487668C>T	ENST00000247153.3	-	4	477	c.236G>A	c.(235-237)cGa>cAa	p.R79Q	CFP_ENST00000480317.1_5'UTR|CFP_ENST00000396992.3_Missense_Mutation_p.R79Q|CFP_ENST00000377005.2_Missense_Mutation_p.R79Q	NM_002621.2	NP_002612.1	P27918	PROP_HUMAN	complement factor properdin	79	TSP type-1 1.				complement activation, alternative pathway|defense response to bacterium	extracellular space				breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)	18						CAGGGACCATCGTGGGGACCT	0.612000													5	5					0	0	0.00116845	0	0
C7orf60	154743	broad.mit.edu	37	7	112462292	112462292	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:112462292A>G	ENST00000297145.4	-	5	890	c.725T>C	c.(724-726)gTt>gCt	p.V242A		NM_152556.2	NP_689769.2	Q1RMZ1	CG060_HUMAN	chromosome 7 open reading frame 60	242										breast(1)|endometrium(2)|lung(7)|ovary(3)|prostate(2)|skin(1)|urinary_tract(1)	17						GAGAGAGAAAACAACCACATG	0.408000													12	18					0	0	0.000978159	0	0
DSP	1832	broad.mit.edu	37	6	7584933	7584933	+	Missense_Mutation	SNP	C	C	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:7584933C>A	ENST00000379802.3	+	24	7779	c.7438C>A	c.(7438-7440)Cag>Aag	p.Q2480K	DSP_ENST00000418664.2_Missense_Mutation_p.Q1881K	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2480	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AATGTCTGTTCAGGAGGCCTA	0.423000													49	83					3.89483e-19	1.9225e-18	0.000781405	1	0
TMEM201	199953	broad.mit.edu	37	1	9657101	9657101	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:9657101C>T	ENST00000340305.5	+	3	428	c.419C>T	c.(418-420)cCc>cTc	p.P140L	TMEM201_ENST00000377376.4_Missense_Mutation_p.P140L|TMEM201_ENST00000340381.6_Missense_Mutation_p.P140L	NM_001010866.3	NP_001010866.1	Q5SNT2	TM201_HUMAN	transmembrane protein 201	140						integral to membrane|nuclear inner membrane				lung(3)|upper_aerodigestive_tract(1)	4	all_lung(157;0.222)	all_epithelial(116;2.09e-14)|Renal(390;0.000469)|all_lung(118;0.000521)|Lung NSC(185;0.000744)|Colorectal(325;0.0062)|Breast(348;0.0157)|Hepatocellular(190;0.0228)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.5e-08)|COAD - Colon adenocarcinoma(227;1.36e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|STAD - Stomach adenocarcinoma(132;0.00345)|READ - Rectum adenocarcinoma(331;0.0419)		GCCTTCGCTCCCCGCGAGGAG	0.672000													16	22					0	0	0.00229938	0	0
VPS39	23339	broad.mit.edu	37	15	42458803	42458803	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:42458803G>A	ENST00000318006.5	-	15	1726	c.1564C>T	c.(1564-1566)Ctg>Ttg	p.L522L	VPS39_ENST00000348544.4_Silent_p.L533L	NM_015289.2	NP_056104.2	Q96JC1	VPS39_HUMAN	vacuolar protein sorting 39 homolog (S. cerevisiae)	533					protein transport	HOPS complex|late endosome membrane|lysosomal membrane	small GTPase regulator activity			breast(2)|kidney(5)|large_intestine(4)|lung(8)|ovary(1)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28		all_cancers(109;6.78e-16)|all_epithelial(112;1.81e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;3.05e-06)		TGGCCTTTCAGAGGGGAGTTG	0.557000													9	41					0	0	0.000442599	0	0
PRX	57716	broad.mit.edu	37	19	40902141	40902141	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:40902141G>A	ENST00000324001.7	-	7	2388	c.2118C>T	c.(2116-2118)ctC>ctT	p.L706L	PRX_ENST00000291825.7_3'UTR	NM_181882.2	NP_870998.2	Q9BXM0	PRAX_HUMAN	periaxin	706	55 X 5 AA approximate tandem repeats of [LVMAG]-[PSREQC]-[EDKL]-[LIVMAP]- [AQKHRPE]; that may have a tripeptide spacer of [LV]-P-[KER].				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(12)|ovary(2)|prostate(3)|skin(1)|urinary_tract(9)	47			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCACCTCTGGGAGGTGCACAT	0.567000													19	117					0	0	0.00278032	0	0
CERS5	91012	broad.mit.edu	37	12	50524370	50524370	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:50524370C>T	ENST00000317551.6	-	10	1261	c.1137G>A	c.(1135-1137)cgG>cgA	p.R379R	CERS5_ENST00000422340.2_Silent_p.R321R	NM_147190.2	NP_671723.1	Q8N5B7	CERS5_HUMAN	ceramide synthase 5	379					ceramide biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|nuclear membrane	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity										GACCATTCACCCGATTGGCAC	0.522000													38	50					0	0	0.00128727	0	0
RECK	8434	broad.mit.edu	37	9	36087828	36087828	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:36087828C>T	ENST00000377966.3	+	9	1341	c.775C>T	c.(775-777)Cct>Tct	p.P259S		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	259	5 X Knot repeats.					anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			GCCTCAAGATCCTCTTTGGCA	0.483000													20	66					0	0	0.00152264	0	0
PRKCB	5579	broad.mit.edu	37	16	24231416	24231416	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:24231416G>A	ENST00000321728.7	+	17	2173	c.1998G>A	c.(1996-1998)gaG>gaA	p.E666E	PRKCB_ENST00000303531.7_3'UTR	NM_212535.2	NP_997700.1	P05771	KPCB_HUMAN	protein kinase C, beta	666	AGC-kinase C-terminal.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	CTAACCCAGAGTTTGTCATTA	0.433000													32	50					0	0	0.00148497	0	0
MALT1	10892	broad.mit.edu	37	18	56390461	56390461	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr18:56390461C>T	ENST00000348428.3	+	10	1458	c.1200C>T	c.(1198-1200)ctC>ctT	p.L400L	RP11-126O1.4_ENST00000588835.1_RNA|MALT1_ENST00000345724.3_Silent_p.L389L	NM_006785.2|NM_173844.1	NP_006776.1|NP_776216.1	Q9UDY8	MALT1_HUMAN	mucosa associated lymphoid tissue lymphoma translocation gene 1	400	Caspase-like.				activation of NF-kappaB-inducing kinase activity|anti-apoptosis|nuclear export|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphorylation|positive regulation of protein ubiquitination|positive regulation of T cell cytokine production|protein oligomerization|proteolysis|T cell receptor signaling pathway	CBM complex|cytosol|nucleus|perinuclear region of cytoplasm	cysteine-type endopeptidase activity|protein self-association|signal transducer activity|ubiquitin-protein ligase activity			central_nervous_system(1)|large_intestine(7)|lung(1)|ovary(2)|skin(1)	12						AGTTTTTACTCCTTTTAGACA	0.313000			T	BIRC3	MALT								13	45					0	0	0.00185496	0	0
PTGER3	5733	broad.mit.edu	37	1	71418690	71418690	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:71418690C>T	ENST00000356595.4	-	4	1367	c.1157G>A	c.(1156-1158)gGg>gAg	p.G386E	PTGER3_ENST00000370932.2_Intron|PTGER3_ENST00000460330.1_Intron|PTGER3_ENST00000351052.5_Intron|PTGER3_ENST00000370931.3_Intron|PTGER3_ENST00000414819.1_3'UTR|PTGER3_ENST00000354608.5_Intron	NM_198718.1	NP_942011.1	P43115	PE2R3_HUMAN	prostaglandin E receptor 3 (subtype EP3)	0					cell death|positive regulation of fever generation|transcription, DNA-dependent	integral to plasma membrane|nuclear envelope	ligand-dependent nuclear receptor activity|prostaglandin E receptor activity			endometrium(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	25					Bimatoprost(DB00905)	TTGTACTTGCCCACAATGTGc	0.373000													42	98					0	0	0.00195071	0	0
MINK1	50488	broad.mit.edu	37	17	4789256	4789256	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:4789256C>T	ENST00000355280.6	+	8	886	c.690C>T	c.(688-690)gcC>gcT	p.A230A	MINK1_ENST00000347992.7_Silent_p.A230A|MINK1_ENST00000453408.3_Silent_p.A230A	NM_001024937.3|NM_015716.4|NM_153827.4	NP_001020108.1|NP_056531.1|NP_722549.2	Q8N4C8	MINK1_HUMAN	misshapen-like kinase 1	230	Protein kinase.				JNK cascade	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)|stomach(1)	6						CAGAGGGAGCCCCCCGTAAGT	0.567000													8	21					0	0	0.000442599	0	0
PSG8	440533	broad.mit.edu	37	19	43262160	43262160	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:43262160G>A	ENST00000404209.4	-	3	799	c.703C>T	c.(703-705)Ctc>Ttc	p.L235F	PSG8_ENST00000406636.3_Missense_Mutation_p.L113F|PSG8_ENST00000401467.2_Intron|PSG8_ENST00000306511.4_Missense_Mutation_p.L235F|PSG8_ENST00000600709.1_5'UTR	NM_001130167.1	NP_001123639.1	Q9UQ74	PSG8_HUMAN	pregnancy specific beta-1-glycoprotein 8	235						extracellular region				breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(19)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	40		Prostate(69;0.00899)				TCACGGAGGAGATTCAGGGTG	0.527000													38	183					0	0	0.00148497	0	0
CPB1	1360	broad.mit.edu	37	3	148577630	148577630	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:148577630G>A	ENST00000491148.1	+	12	1429	c.1095G>A	c.(1093-1095)tgG>tgA	p.W365*	CPB1_ENST00000282957.4_Nonsense_Mutation_p.W365*|RP11-680B3.2_ENST00000488190.1_RNA|CPB1_ENST00000498639.1_3'UTR			P15086	CBPB1_HUMAN	carboxypeptidase B1 (tissue)	365					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	38			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			CTGACGACTGGGCTTATGACC	0.448000													24	56					0	0	0.00047179	0	0
NLRP3	114548	broad.mit.edu	37	1	247587607	247587607	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:247587607C>T	ENST00000366497.2	+	4	1642	c.862C>T	c.(862-864)Cac>Tac	p.H288Y	NLRP3_ENST00000366496.2_Missense_Mutation_p.H288Y|NLRP3_ENST00000391827.2_Missense_Mutation_p.H288Y|NLRP3_ENST00000474792.1_3'UTR|NLRP3_ENST00000336119.3_Missense_Mutation_p.H288Y|NLRP3_ENST00000391828.3_Missense_Mutation_p.H288Y|NLRP3_ENST00000348069.2_Missense_Mutation_p.H288Y	NM_001127461.2	NP_001120933.1	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3	288	NACHT.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			NS(1)|breast(3)|endometrium(6)|kidney(1)|large_intestine(19)|lung(85)|ovary(9)|pancreas(2)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	142	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			CCCACCCATCCACAAGATCGT	0.552000													33	53					0	0	0.00058488	0	0
OR4A16	81327	broad.mit.edu	37	11	55110948	55110948	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:55110948C>T	ENST00000314721.2	+	1	322	c.272C>T	c.(271-273)tCc>tTc	p.S91F		NM_001005274.1	NP_001005274.1	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A, member 16	91					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(28)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	51						ATCGCTATTTCCTTGTCAGCT	0.438000													62	94					0	0	0.000781405	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092879	151092879	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:151092879C>T	ENST00000370340.3	+	3	1010	c.743C>T	c.(742-744)aCc>aTc	p.T248I	MAGEA4_ENST00000393920.1_Missense_Mutation_p.T248I|MAGEA4_ENST00000370337.4_Missense_Mutation_p.T248I|MAGEA4_ENST00000393921.1_Missense_Mutation_p.T248I|MAGEA4_ENST00000370335.1_Missense_Mutation_p.T248I|MAGEA4_ENST00000276344.2_Missense_Mutation_p.T248I|MAGEA4_ENST00000360243.2_Missense_Mutation_p.T248I			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	248	MAGE.						protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					AAACTGCTCACCCAAGATTGG	0.587000													20	76					0	0	0.00121646	0	0
PREX2	80243	broad.mit.edu	37	8	69020350	69020350	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:69020350C>T	ENST00000288368.4	+	24	2999	c.2722C>T	c.(2722-2724)Cgt>Tgt	p.R908C		NM_024870.2|NM_025170.4	NP_079146.2|NP_079446.3	Q70Z35	PREX2_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	908					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			NS(6)|biliary_tract(1)|breast(4)|endometrium(11)|kidney(16)|large_intestine(25)|liver(4)|lung(57)|ovary(2)|pancreas(4)|prostate(3)|skin(42)|upper_aerodigestive_tract(1)|urinary_tract(2)	178						GCAGTTTTCTCGTGTACTGAA	0.393000													7	26					0	0	0.00198382	0	0
FPGT-TNNI3K	100526835	broad.mit.edu	37	1	74701860	74701860	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:74701860G>A	ENST00000370895.1	+	4	453	c.418G>A	c.(418-420)Gaa>Aaa	p.E140K	FPGT-TNNI3K_ENST00000370899.3_Missense_Mutation_p.E140K|TNNI3K_ENST00000370891.2_Missense_Mutation_p.E140K|TNNI3K_ENST00000370893.1_Missense_Mutation_p.E140K|FPGT-TNNI3K_ENST00000557284.1_Missense_Mutation_p.E140K|TNNI3K_ENST00000326637.3_Missense_Mutation_p.E39K			Q59H18	TNI3K_HUMAN		39						cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding										GCAGATCAAGGAAAAAGAACT	0.299000													37	77					0	0	0.00128727	0	0
PLCB1	23236	broad.mit.edu	37	20	8717790	8717790	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:8717790G>A	ENST00000378641.3	+	20	2634	c.2159G>A	c.(2158-2160)gGa>gAa	p.G720E	PLCB1_ENST00000378637.2_Missense_Mutation_p.G720E|PLCB1_ENST00000494924.1_3'UTR|PLCB1_ENST00000338037.6_Missense_Mutation_p.G720E	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	720	C2.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						ACATCCCAAGGAAATGCTGTG	0.383000													18	56					0	0	0.00121646	0	0
NTNG1	22854	broad.mit.edu	37	1	107937858	107937858	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:107937858C>T	ENST00000370067.1	+	4	1597	c.970C>T	c.(970-972)Cca>Tca	p.P324S	NTNG1_ENST00000370066.1_Missense_Mutation_p.P324S|NTNG1_ENST00000370072.3_Missense_Mutation_p.P324S|NTNG1_ENST00000370070.2_Missense_Mutation_p.P324S|NTNG1_ENST00000370068.1_Missense_Mutation_p.P324S|NTNG1_ENST00000370073.2_Missense_Mutation_p.P324S|NTNG1_ENST00000370071.2_Missense_Mutation_p.P324S|NTNG1_ENST00000370065.1_Missense_Mutation_p.P324S|NTNG1_ENST00000370074.4_Missense_Mutation_p.P324S|NTNG1_ENST00000370061.3_Missense_Mutation_p.P324S|NTNG1_ENST00000542803.1_Missense_Mutation_p.P324S			Q9Y2I2	NTNG1_HUMAN	netrin G1	324	Laminin EGF-like 1.				axonogenesis	anchored to plasma membrane	protein binding	p.P324A(3)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		CACTACAGGTCCAGACTGTGG	0.493000													48	106					0	0	0.000781405	0	0
SPG11	80208	broad.mit.edu	37	15	44890914	44890914	+	Silent	SNP	T	T	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:44890914T>C	ENST00000261866.7	-	22	3823	c.3807A>G	c.(3805-3807)agA>agG	p.R1269R	SPG11_ENST00000427534.2_Silent_p.R1269R|SPG11_ENST00000535302.2_Silent_p.R1269R|SPG11_ENST00000558319.1_Silent_p.R1269R	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	1269					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TCATATCAACTCTGAGCTTGA	0.418000													20	58					0	0	0.00188189	0	0
SRGAP3	9901	broad.mit.edu	37	3	9166422	9166422	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:9166422C>T	ENST00000383836.3	-	2	674	c.247G>A	c.(247-249)Gag>Aag	p.E83K	SRGAP3_ENST00000360413.3_Missense_Mutation_p.E83K|SRGAP3_ENST00000433332.3_5'UTR	NM_014850.3	NP_055665.1	O43295	SRGP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 3	83	FCH.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding		SRGAP3/RAF1(6)	breast(1)|endometrium(2)|kidney(21)|large_intestine(7)|lung(13)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	54				OV - Ovarian serous cystadenocarcinoma(96;0.0563)		AACTGGTGCTCCCGGGAGCTG	0.592000			T	RAF1	pilocytic astrocytoma								23	41					0	0	0.00047179	0	0
SPRYD3	84926	broad.mit.edu	37	12	53470996	53470996	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:53470996G>A	ENST00000301463.4	-	2	159	c.73C>T	c.(73-75)Ctg>Ttg	p.L25L	SPRYD3_ENST00000547837.1_Silent_p.L62L	NM_032840.2	NP_116229.1	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	25	B30.2/SPRY.									central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						CGCCAATTCAGAAACCGGTAG	0.507000													11	30					0	0	0.000978159	0	0
ZNF280C	55609	broad.mit.edu	37	X	129349848	129349848	+	Silent	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:129349848A>G	ENST00000370978.4	-	14	1908	c.1755T>C	c.(1753-1755)gcT>gcC	p.A585A		NM_017666.4	NP_060136.1	Q8ND82	Z280C_HUMAN	zinc finger protein 280C	585					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(4)|large_intestine(9)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	26						CTTTGGACTTAGCTATACGTC	0.373000													38	195					0	0	0.00128727	0	0
CYP2C9	1559	broad.mit.edu	37	10	96741125	96741125	+	Nonsense_Mutation	SNP	A	A	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:96741125A>T	ENST00000260682.6	+	7	1159	c.1147A>T	c.(1147-1149)Aag>Tag	p.K383*		NM_000771.3	NP_000762.2	P11712	CP2C9_HUMAN	cytochrome P450, family 2, subfamily C, polypeptide 9	383					exogenous drug catabolic process|monocarboxylic acid metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid metabolic process|urea metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	(S)-limonene 6-monooxygenase activity|(S)-limonene 7-monooxygenase activity|4-hydroxyacetophenone monooxygenase activity|caffeine oxidase activity|drug binding|electron carrier activity|heme binding|oxygen binding|steroid hydroxylase activity			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	34		Colorectal(252;0.0902)		all cancers(201;6.93e-05)	Acenocoumarol(DB01418)|Alosetron(DB00969)|Amiodarone(DB01118)|Antihemophilic Factor(DB00025)|Aprepitant(DB00673)|Bosentan(DB00559)|Carprofen(DB00821)|Carvedilol(DB01136)|Celecoxib(DB00482)|Clomipramine(DB01242)|Dapsone(DB00250)|Delavirdine(DB00705)|Desloratadine(DB00967)|Desogestrel(DB00304)|Diclofenac(DB00586)|Esomeprazole(DB00736)|Etodolac(DB00749)|Fluconazole(DB00196)|Fluoxetine(DB00472)|Flurbiprofen(DB00712)|Fluvastatin(DB01095)|Fluvoxamine(DB00176)|Formoterol(DB00983)|Gemfibrozil(DB01241)|Ginkgo biloba(DB01381)|Glibenclamide(DB01016)|Glimepiride(DB00222)|Glipizide(DB01067)|Guanfacine(DB01018)|Hydromorphone(DB00327)|Ibuprofen(DB01050)|Imipramine(DB00458)|Irbesartan(DB01029)|Ketoconazole(DB01026)|Lansoprazole(DB00448)|Losartan(DB00678)|Lumiracoxib(DB01283)|Marinol(DB00470)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mephenytoin(DB00532)|Metronidazole(DB00916)|Miconazole(DB01110)|Midazolam(DB00683)|Montelukast(DB00471)|Nateglinide(DB00731)|Nelfinavir(DB00220)|Nicardipine(DB00622)|Oxymorphone(DB01192)|Pantoprazole(DB00213)|Paramethadione(DB00617)|Phenprocoumon(DB00946)|Phenytoin(DB00252)|Pravastatin(DB00175)|Quinidine(DB00908)|Ritonavir(DB00503)|Rosiglitazone(DB00412)|Sertraline(DB01104)|Sildenafil(DB00203)|Sulfamethoxazole(DB01015)|Suprofen(DB00870)|Tamoxifen(DB00675)|Tenoxicam(DB00469)|Terfenadine(DB00342)|Tolbutamide(DB01124)|Torasemide(DB00214)|Troleandomycin(DB01361)|Valdecoxib(DB00580)|Valsartan(DB00177)|Voriconazole(DB00582)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zileuton(DB00744)	TCTCATTCCCAAGGTAAGTTT	0.458000													16	43					0	0	0.000422831	0	0
DCLRE1B	64858	broad.mit.edu	37	1	114454751	114454751	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:114454751C>T	ENST00000369563.3	+	4	1983	c.1537C>T	c.(1537-1539)Cag>Tag	p.Q513*	DCLRE1B_ENST00000466480.1_Intron	NM_022836.3	NP_073747.1	Q9H816	DCR1B_HUMAN	DNA cross-link repair 1B	513					cell cycle checkpoint|DNA repair|protection from non-homologous end joining at telomere|telomeric 3' overhang formation|telomeric loop formation	centrosome|chromosome, telomeric region|nucleus	5'-3' exonuclease activity|protein binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(2)|liver(2)|lung(6)|stomach(1)	18	Lung SC(450;0.184)	all_cancers(81;1.46e-05)|all_epithelial(167;2.42e-05)|all_lung(203;0.000353)|Lung NSC(69;0.000518)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAACTTTTTCCAGGCAGGGTA	0.483000								Other identified genes with known or suspected DNA repair function					41	119					0	0	0.000781405	0	0
CPAMD8	27151	broad.mit.edu	37	19	17085952	17085952	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:17085952G>A	ENST00000443236.1	-	17	2197	c.2166C>T	c.(2164-2166)ttC>ttT	p.F722F	CPAMD8_ENST00000388925.4_Silent_p.F461F	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	675						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						AAGGCCACGGGAAGACAGAGG	0.567000													10	19					0	0	0.000673444	0	0
TRMT5	57570	broad.mit.edu	37	14	61446310	61446310	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr14:61446310C>T	ENST00000261249.6	-	2	690	c.306G>A	c.(304-306)agG>agA	p.R102R	RP11-193F5.1_ENST00000553946.1_RNA	NM_020810.2	NP_065861.2	Q32P41	TRMT5_HUMAN	tRNA methyltransferase 5	102						cytoplasm	tRNA (guanine-N1-)-methyltransferase activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(5)|lung(1)	11				OV - Ovarian serous cystadenocarcinoma(108;0.0873)		CTATTTCTTTCCTCACTTTAA	0.408000													36	68					0	0	0.000692331	0	0
MGAM	8972	broad.mit.edu	37	7	141764249	141764249	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:141764249C>T	ENST00000475668.2	+	37	4465	c.4411C>T	c.(4411-4413)Cca>Tca	p.P1471S	MGAM_ENST00000549489.2_Missense_Mutation_p.P1471S			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	1471	Glucoamylase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GCAGATCCTCCCAGACGGCTC	0.582000													10	6					0	0	0.000442599	0	0
NTF3	4908	broad.mit.edu	37	12	5603469	5603469	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:5603469C>T	ENST00000423158.3	+	2	340	c.128C>T	c.(127-129)tCg>tTg	p.S43L	NTF3_ENST00000331010.6_Missense_Mutation_p.S30L|NTF3_ENST00000535299.1_Intron	NM_001102654.1	NP_001096124.1	P20783	NTF3_HUMAN	neurotrophin 3	30					signal transduction	extracellular region	growth factor activity|neurotrophin receptor binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(3)|upper_aerodigestive_tract(1)	22						CCAGAAGACTCGCTCAATTCC	0.428000													28	70					0	0	0.00127121	0	0
CDH18	1016	broad.mit.edu	37	5	19520879	19520879	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:19520879C>T	ENST00000507958.1	-	12	2389	c.1399G>A	c.(1399-1401)Gat>Aat	p.D467N	CDH18_ENST00000506372.1_Missense_Mutation_p.D467N|CDH18_ENST00000511273.1_Missense_Mutation_p.D467N|CDH18_ENST00000274170.4_Missense_Mutation_p.D467N|CDH18_ENST00000502796.1_Missense_Mutation_p.D467N|CDH18_ENST00000382275.1_Missense_Mutation_p.D467N			Q13634	CAD18_HUMAN	cadherin 18, type 2	467	Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(24)|lung(76)|ovary(5)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)	138	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CTCAGCAAATCAGGATTATCT	0.373000													34	47					0	0	0.00285205	0	0
ANKEF1	63926	broad.mit.edu	37	20	10030496	10030496	+	Missense_Mutation	SNP	G	G	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:10030496G>T	ENST00000378380.3	+	6	1608	c.1279G>T	c.(1279-1281)Ggg>Tgg	p.G427W	ANKEF1_ENST00000488991.1_3'UTR|SNAP25-AS1_ENST00000421143.2_RNA|ANKEF1_ENST00000378392.1_Missense_Mutation_p.G427W|SNAP25-AS1_ENST00000603542.1_RNA	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		AGGAAAGAAAGGGAAATTTGT	0.418000													21	53					7.41877e-09	3.63743e-08	0.00188189	1	0
FREM1	158326	broad.mit.edu	37	9	14804986	14804986	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:14804986C>T	ENST00000380881.4	-	20	4257	c.3442G>A	c.(3442-3444)Gaa>Aaa	p.E1148K	FREM1_ENST00000422223.2_Missense_Mutation_p.E1147K|FREM1_ENST00000380880.3_Missense_Mutation_p.E1147K			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1147					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TCAGGAGCTTCATCATTTGTG	0.363000													25	31					0	0	0.000586117	0	0
THSD7B	80731	broad.mit.edu	37	2	138425350	138425350	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:138425350G>A	ENST00000409968.1	+	27	4836	c.4658G>A	c.(4657-4659)cGa>cAa	p.R1553Q	THSD7B_ENST00000413152.2_Missense_Mutation_p.R1525Q|THSD7B_ENST00000272643.3_Missense_Mutation_p.R1556Q					thrombospondin, type I, domain containing 7B									p.R1556Q(1)		NS(3)|breast(3)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(14)|lung(57)|ovary(4)|pancreas(3)|prostate(11)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	134				BRCA - Breast invasive adenocarcinoma(221;0.19)		ACAGATGGCCGAGTAAAAATT	0.378000													5	9					0	0	0.000602214	0	0
SMAD3	4088	broad.mit.edu	37	15	67482846	67482846	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:67482846C>T	ENST00000327367.4	+	9	1560	c.1250C>T	c.(1249-1251)cCa>cTa	p.P417L	SMAD3_ENST00000439724.3_Missense_Mutation_p.P373L|SMAD3_ENST00000537194.2_Missense_Mutation_p.P222L|SMAD3_ENST00000540846.2_Missense_Mutation_p.P312L	NM_005902.3	NP_005893.1	P84022	SMAD3_HUMAN	SMAD family member 3	417	MH2.				activation of caspase activity|cell cycle arrest|cell-cell junction organization|evasion of host defenses by virus|immune response|induction of apoptosis|negative regulation of cell growth|negative regulation of mitotic cell cycle|negative regulation of protein catabolic process|negative regulation of protein phosphorylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|protein stabilization|regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|transport|wound healing	cytosol|nuclear inner membrane|receptor complex	beta-catenin binding|co-SMAD binding|metal ion binding|protein homodimerization activity|protein kinase binding|R-SMAD binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transforming growth factor beta receptor binding|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|ubiquitin protein ligase binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|large_intestine(11)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	31				Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(7;0.125)		ATGGGCTCCCCAAGCATCCGC	0.547000													15	19					0	0	0.000566183	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68780325	68780325	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:68780325C>T	ENST00000508048.1	-	9	1108	c.1073G>A	c.(1072-1074)gGa>gAa	p.G358E	TMPRSS11A_ENST00000334830.7_Missense_Mutation_p.G362E|TMPRSS11A_ENST00000396188.2_Missense_Mutation_p.G359E|RP11-453E17.1_ENST00000500538.2_RNA			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	362	Peptidase S1.				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						ATCATAAATTCCTTCCATATA	0.358000													44	68					0	0	0.000781405	0	0
PNMAL1	55228	broad.mit.edu	37	19	46973464	46973464	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:46973464C>T	ENST00000313683.10	-	2	1134	c.829G>A	c.(829-831)Ggt>Agt	p.G277S	PNMAL1_ENST00000602246.1_Intron|PNMAL1_ENST00000438932.2_Missense_Mutation_p.G277S	NM_001103149.1|NM_018215.3	NP_001096619.1|NP_060685.2	Q86V59	PNML1_HUMAN	paraneoplastic Ma antigen family-like 1	277										cervix(1)|endometrium(2)|large_intestine(8)|lung(8)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		TCAGCATCACCCACCTCAGGA	0.507000													27	105					0	0	0.000720815	0	0
KDR	3791	broad.mit.edu	37	4	55984967	55984967	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:55984967C>T	ENST00000263923.4	-	3	457	c.161_splice	c.e3-1	p.R54_splice		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	54	Ig-like C2-type 1.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CCCTCTGTCCCCTGAAAAATT	0.428000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			22	48					0	0	0.00047179	0	0
CCDC178	374864	broad.mit.edu	37	18	30992029	30992029	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr18:30992029G>A	ENST00000383096.3	-	3	206	c.24C>T	c.(22-24)tcC>tcT	p.S8S	CCDC178_ENST00000579947.1_Silent_p.S8S|CCDC178_ENST00000402325.1_Silent_p.S8S|CCDC178_ENST00000300227.8_Silent_p.S8S|CCDC178_ENST00000583930.1_Silent_p.S8S|CCDC178_ENST00000406524.2_Silent_p.S8S|CCDC178_ENST00000579916.1_Silent_p.S8S|CCDC178_ENST00000403303.1_Silent_p.S8S					coiled-coil domain containing 178									p.S8S(1)									TGGAAGAAGAGGAAACTGTCT	0.229000													10	23					0	0	0.00136819	0	0
HECA	51696	broad.mit.edu	37	6	139488217	139488217	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:139488217C>T	ENST00000367658.2	+	2	1353	c.1068C>T	c.(1066-1068)atC>atT	p.I356I	RP1-225E12.2_ENST00000589192.1_RNA|RP1-225E12.2_ENST00000415194.2_RNA|RP1-225E12.2_ENST00000586266.1_RNA|RP1-225E12.3_ENST00000585874.1_RNA|RP1-225E12.2_ENST00000586229.1_RNA|RP1-225E12.2_ENST00000588638.1_RNA|RP1-225E12.2_ENST00000587577.1_RNA|RP1-225E12.2_ENST00000590679.1_RNA|RP1-225E12.2_ENST00000588529.1_RNA	NM_016217.2	NP_057301.1	Q9UBI9	HDC_HUMAN	headcase homolog (Drosophila)	356					respiratory tube development					endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)|skin(1)	15				GBM - Glioblastoma multiforme(68;0.000252)|OV - Ovarian serous cystadenocarcinoma(155;0.000387)		TCACTCACATCCCCAGGCATA	0.607000													15	35					0	0	0.000422831	0	0
SLCO1B3	28234	broad.mit.edu	37	12	21036450	21036450	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:21036450G>A	ENST00000381545.3	+	13	1815	c.1596G>A	c.(1594-1596)agG>agA	p.R532R	SLCO1B3_ENST00000553473.1_Silent_p.R532R|SLCO1B3_ENST00000261196.2_Silent_p.R532R|LST3_ENST00000540229.1_Silent_p.R532R|SLCO1B7_ENST00000554957.1_Intron|LST3_ENST00000381541.3_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	532					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					CTTGTACAAGGAAATTTTTCA	0.373000													26	53					0	0	0.00106085	0	0
POTEF	728378	broad.mit.edu	37	2	130869581	130869581	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:130869581C>T	ENST00000357462.5	-	4	997	c.904G>A	c.(904-906)Gat>Aat	p.D302N	POTEF_ENST00000360967.5_Missense_Mutation_p.D302N|POTEF_ENST00000361163.4_Missense_Mutation_p.D312N|POTEF_ENST00000409914.2_Missense_Mutation_p.D302N			A5A3E0	POTEF_HUMAN	POTE ankyrin domain family, member F	302						cell cortex	ATP binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(28)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	53						CCATATCTATCCAGTGCATTT	0.323000													25	34					0	0	0.00278032	0	0
TRBV11-2	28581	broad.mit.edu	37	7	142197589	142197589	+	RNA	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:142197589G>A	ENST00000471935.1	-	0	388																											CTGGCACAGAGATACACGGCC	0.517000													64	180					0	0	0.000781405	0	0
DNAH8	1769	broad.mit.edu	37	6	38825330	38825330	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:38825330G>A	ENST00000359357.3	+	40	5373	c.5119G>A	c.(5119-5121)Gat>Aat	p.D1707N	DNAH8_ENST00000449981.2_Missense_Mutation_p.D1924N|DNAH8_ENST00000441566.1_Missense_Mutation_p.D1707N					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						GTGGACACACGATTCAGAAGA	0.343000													15	52					0	0	0.000308642	0	0
NLRP8	126205	broad.mit.edu	37	19	56466752	56466752	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:56466752C>T	ENST00000291971.3	+	3	1399	c.1328C>T	c.(1327-1329)tCc>tTc	p.S443F	NLRP8_ENST00000590542.1_Missense_Mutation_p.S443F	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	443	NACHT.					cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		GAGAACTTTTCCAGAAAGATC	0.473000													13	83					0	0	0.00185496	0	0
ARNT	405	broad.mit.edu	37	1	150804825	150804825	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:150804825A>C	ENST00000358595.5	-	9	1054	c.854T>G	c.(853-855)gTg>gGg	p.V285G	ARNT_ENST00000515192.1_Missense_Mutation_p.V276G|ARNT_ENST00000505755.1_Missense_Mutation_p.V270G|ARNT_ENST00000468970.1_5'UTR|ARNT_ENST00000354396.2_Missense_Mutation_p.V285G	NM_001197325.1|NM_001668.3|NM_178427.2	NP_001184254.1|NP_001659.1|NP_848514.1	P27540	ARNT_HUMAN	aryl hydrocarbon receptor nuclear translocator	285					positive regulation of hormone biosynthetic process|positive regulation vascular endothelial growth factor production|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|response to hypoxia		aryl hydrocarbon receptor binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(11)|prostate(2)|skin(4)|stomach(1)	34	all_lung(15;9e-35)|Lung NSC(24;3.45e-31)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.108)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.02)|BRCA - Breast invasive adenocarcinoma(12;0.00606)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCTGTTCCTCACAAAGCTCAG	0.438000			T	ETV6	AML								27	134					0	0	0.001512	0	0
CYP4F8	11283	broad.mit.edu	37	19	15728888	15728888	+	RNA	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:15728888G>A	ENST00000441682.2	+	0	340							P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F, polypeptide 8						prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(1)	26						TGAGGTGGTTGGGCCCCATCA	0.597000													11	61					0	0	0.00185496	0	0
ZKSCAN8	7745	broad.mit.edu	37	6	28119712	28119712	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:28119712C>T	ENST00000330236.6	+	4	833	c.649C>T	c.(649-651)Cag>Tag	p.Q217*	ZKSCAN8_ENST00000457389.2_Nonsense_Mutation_p.Q217*	NM_001278119.1|NM_001278121.1|NM_001278122.1|NM_006298.2	NP_001265048.1|NP_001265050.1|NP_001265051.1|NP_006289.2			zinc finger with KRAB and SCAN domains 8																		AGCAGGGTTCCAGGTGAGTTG	0.493000													25	44					0	0	0.00127121	0	0
GPR112	139378	broad.mit.edu	37	X	135428079	135428079	+	Missense_Mutation	SNP	T	T	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:135428079T>A	ENST00000394143.1	+	6	2505	c.2214T>A	c.(2212-2214)aaT>aaA	p.N738K	GPR112_ENST00000412101.1_Missense_Mutation_p.N533K|GPR112_ENST00000394141.1_Missense_Mutation_p.N533K|GPR112_ENST00000370652.1_Missense_Mutation_p.N738K|GPR112_ENST00000287534.4_Missense_Mutation_p.N675K	NM_153834.3	NP_722576.3	Q8IZF6	GP112_HUMAN	G protein-coupled receptor 112	738					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					GGTTTGCTAATTTCTCCATAG	0.388000													13	56					0	0	0.000308642	0	0
CAPZA3	93661	broad.mit.edu	37	12	18891911	18891911	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:18891911C>T	ENST00000317658.3	+	1	867	c.709C>T	c.(709-711)Caa>Taa	p.Q237*		NM_033328.2	NP_201585.1	Q96KX2	CAZA3_HUMAN	capping protein (actin filament) muscle Z-line, alpha 3	237					actin cytoskeleton organization|actin filament capping	F-actin capping protein complex	actin binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)	19	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)	Hepatocellular(102;0.194)				GAACAAATTTCAAGCTGCAGT	0.423000													23	48					0	0	0.00278032	0	0
ABCA13	154664	broad.mit.edu	37	7	48450124	48450124	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:48450124G>A	ENST00000435803.1	+	40	12102	c.12078G>A	c.(12076-12078)acG>acA	p.T4026T		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	4026	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CAGGTCGTACGATCATCTTCA	0.607000													22	88					0	0	0.000720815	0	0
OR2J2	26707	broad.mit.edu	37	6	29141462	29141462	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:29141462G>A	ENST00000377167.2	+	1	152	c.50G>A	c.(49-51)gGa>gAa	p.G17E		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	17					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						ATTCTACTTGGATTTTCTAAT	0.358000													42	108					0	0	0.000680045	0	0
ARAP2	116984	broad.mit.edu	37	4	36212304	36212304	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:36212304G>A	ENST00000303965.4	-	6	1684	c.1195C>T	c.(1195-1197)Cga>Tga	p.R399*		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	399					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding	p.R399*(1)		breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TTGTCCTCTCGAGGTATCCAA	0.338000													44	123					0	0	0.000781405	0	0
OR5M8	219484	broad.mit.edu	37	11	56258182	56258182	+	Missense_Mutation	SNP	G	G	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:56258182G>T	ENST00000327216.2	-	1	689	c.665C>A	c.(664-666)cCt>cAt	p.P222H		NM_001005282.1	NP_001005282.1	Q8NGP6	OR5M8_HUMAN	olfactory receptor, family 5, subfamily M, member 8	222					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(22)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	Esophageal squamous(21;0.00352)					TAAAATAGCAGGGAAAATGTA	0.408000													12	29					1.49906e-05	7.33763e-05	0.00244969	1	0
FAT1	2195	broad.mit.edu	37	4	187541133	187541133	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:187541133G>A	ENST00000441802.2	-	10	6816	c.6607C>T	c.(6607-6609)Cac>Tac	p.H2203Y		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2203	Cadherin 20.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GCCTGCACGTGGACCACAGGG	0.488000										HNSCC(5;0.00058)			35	97					0	0	0.00128727	0	0
KCNA6	3742	broad.mit.edu	37	12	4920465	4920465	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:4920465A>T	ENST00000433855.1	+	1	2124	c.1258A>T	c.(1258-1260)Atg>Ttg	p.M420L	KCNA6_ENST00000280684.3_Missense_Mutation_p.M420L	NM_002235.3	NP_002226.1	P17658	KCNA6_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 6	420						voltage-gated potassium channel complex	voltage-gated potassium channel activity			NS(1)|breast(3)|endometrium(5)|large_intestine(6)|lung(17)|ovary(3)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(5)	49						AGTGGTTACAATGACCACGGT	0.587000										HNSCC(72;0.22)			34	68					0	0	0.000953801	0	0
PRLR	5618	broad.mit.edu	37	5	35065851	35065851	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:35065851G>A	ENST00000382002.5	-	10	1635	c.1209C>T	c.(1207-1209)atC>atT	p.I403I	PRLR_ENST00000231423.3_Intron|PRLR_ENST00000342362.5_Silent_p.I302I|PRLR_ENST00000397391.3_Intron|PRLR_ENST00000511486.1_Silent_p.I302I|PRLR_ENST00000513753.1_Intron|PRLR_ENST00000542609.1_Intron|PRLR_ENST00000310101.5_Intron|PRLR_ENST00000348262.3_Intron	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	403					activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	GAAAATAGGGGATTTTGCCTT	0.488000													59	138					0	0	0.000781405	0	0
LGALS13	29124	broad.mit.edu	37	19	40095889	40095889	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:40095889G>A	ENST00000221797.4	+	3	209	c.164G>A	c.(163-165)cGa>cAa	p.R55Q		NM_013268.2	NP_037400.1	Q9UHV8	PP13_HUMAN	lectin, galactoside-binding, soluble, 13	55	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			lung(5)|ovary(1)|urinary_tract(1)	7	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			TTCCGTTTCCGAGTGCACTTT	0.498000													7	53					0	0	0.000274275	0	0
ZAN	7455	broad.mit.edu	37	7	100369572	100369572	+	RNA	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:100369572C>T	ENST00000542585.1	+	0	5502				ZAN_ENST00000449052.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000348028.3_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CTGTGCCGCTCCCTGCAGGCC	0.647000													8	37					0	0	0.000157383	0	0
MYO5A	4644	broad.mit.edu	37	15	52681452	52681452	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:52681452G>A	ENST00000399231.3	-	13	1894	c.1651C>T	c.(1651-1653)Caa>Taa	p.Q551*	MYO5A_ENST00000356338.6_Nonsense_Mutation_p.Q551*|MYO5A_ENST00000553916.1_Nonsense_Mutation_p.Q551*|MYO5A_ENST00000399233.2_Nonsense_Mutation_p.Q551*|MYO5A_ENST00000358212.6_Nonsense_Mutation_p.Q551*	NM_000259.3	NP_000250.3	Q9Y4I1	MYO5A_HUMAN	myosin VA (heavy chain 12, myoxin)	551	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		GCAAAATGTTGGATGATGAAA	0.353000													9	41					0	0	0.000673444	0	0
ASRGL1	80150	broad.mit.edu	37	11	62124474	62124474	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:62124474C>T	ENST00000415229.2	+	4	564	c.349C>T	c.(349-351)Ctg>Ttg	p.L117L	ASRGL1_ENST00000301776.5_Silent_p.L117L|ASRGL1_ENST00000535727.1_5'UTR	NM_001083926.1	NP_001077395.1	Q7L266	ASGL1_HUMAN	asparaginase like 1	117					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	7					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	TCATTGCTTTCTGACTGACCA	0.398000													19	38					0	0	0.00278032	0	0
CHTF8	54921	broad.mit.edu	37	16	69154546	69154546	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:69154546G>A	ENST00000448552.2	-	4	269	c.148C>T	c.(148-150)Cct>Tct	p.P50S	CHTF8_ENST00000520529.1_Silent_p.S10S|CHTF8_ENST00000518041.1_Intron|CHTF8_ENST00000306585.6_5'UTR|CHTF8_ENST00000523421.1_Intron|CHTF8_ENST00000519520.1_Silent_p.S10S|CHTF8_ENST00000398235.2_Missense_Mutation_p.P50S|CHTF8_ENST00000522091.1_3'UTR	NM_001039690.3|NM_001040146.3	NP_001034779.1|NP_001035236.1	P0CG13	CTF8_HUMAN	CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)	50					cell cycle|DNA replication	nucleus	DNA binding										ATCAGCACAGGGATTCCCTTT	0.532000													20	40					0	0	0.00278032	0	0
MB21D2	151963	broad.mit.edu	37	3	192517371	192517371	+	Missense_Mutation	SNP	G	G	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:192517371G>C	ENST00000392452.2	-	2	600	c.280C>G	c.(280-282)Cgg>Ggg	p.R94G		NM_178496.3	NP_848591.2	Q8IYB1	M21D2_HUMAN	Mab-21 domain containing 2	94										endometrium(3)|kidney(1)|large_intestine(4)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	31						ACGCCTTCCCGGACACCTCCA	0.473000													12	25					0	0	0.00244969	0	0
SPRED1	161742	broad.mit.edu	37	15	38643623	38643623	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:38643623C>T	ENST00000299084.4	+	7	1953	c.1093C>T	c.(1093-1095)Caa>Taa	p.Q365*		NM_152594.2	NP_689807.1	Q7Z699	SPRE1_HUMAN	sprouty-related, EVH1 domain containing 1	365	SPR.				inactivation of MAPK activity|multicellular organismal development	caveola|nucleus	stem cell factor receptor binding			kidney(6)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25		all_cancers(109;4.88e-13)|all_epithelial(112;1.83e-11)|Lung NSC(122;2.21e-09)|all_lung(180;4.64e-08)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(113;2.41e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		ATGCATATATCAAGTTAGTTG	0.428000									Legius syndrome				38	84					0	0	0.000953801	0	0
SALL1	6299	broad.mit.edu	37	16	51175508	51175508	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:51175508G>A	ENST00000440970.1	-	2	765	c.334C>T	c.(334-336)Cag>Tag	p.Q112*	SALL1_ENST00000251020.4_Nonsense_Mutation_p.Q209*|SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	209					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TGGGAGAACTGGGCCACCGCC	0.607000													34	73					0	0	0.000953801	0	0
OR52M1	119772	broad.mit.edu	37	11	4567252	4567252	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:4567252C>T	ENST00000360213.1	+	1	832	c.832C>T	c.(832-834)Ctg>Ttg	p.L278L		NM_001004137.1	NP_001004137.1	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M, member 1	278					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(2)|lung(9)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		AGTCCACACTCTGCTGGCCAA	0.498000													10	41					0	0	0.000442599	0	0
GOLGA3	2802	broad.mit.edu	37	12	133357462	133357462	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:133357462G>A	ENST00000204726.3	-	18	4062	c.3504C>T	c.(3502-3504)cgC>cgT	p.R1168R	GOLGA3_ENST00000456883.2_Silent_p.R1168R|GOLGA3_ENST00000450791.2_Silent_p.R1168R	NM_005895.3	NP_005886.2	Q08378	GOGA3_HUMAN	golgin A3	1168					intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(4)|lung(33)|ovary(3)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GCTTCATCTGGCGATCCTCCT	0.537000													15	46					0	0	0.00244969	0	0
GGT1	2678	broad.mit.edu	37	22	25019805	25019805	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr22:25019805C>T	ENST00000400382.1	+	11	1697	c.942C>T	c.(940-942)caC>caT	p.H314H	GGT1_ENST00000248923.4_Silent_p.H314H|GGT1_ENST00000406383.2_Silent_p.H314H|GGT1_ENST00000400380.1_Silent_p.H314H|GGT1_ENST00000400383.1_Silent_p.H314H|GGT1_ENST00000466310.1_3'UTR			P19440	GGT1_HUMAN	gamma-glutamyltransferase 1	314					glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding			breast(1)|endometrium(2)|kidney(14)|large_intestine(2)|lung(6)|pancreas(1)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	40					Glutathione(DB00143)	TGACGTACCACCGCATCGTAG	0.617000													9	18					0	0	0.00136819	0	0
SLC19A3	80704	broad.mit.edu	37	2	228563556	228563556	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:228563556A>G	ENST00000258403.3	-	3	946	c.875T>C	c.(874-876)tTt>tCt	p.F292S	SLC19A3_ENST00000409287.1_Intron|SLC19A3_ENST00000541617.1_Missense_Mutation_p.F288S	NM_025243.3	NP_079519.1	Q9BZV2	S19A3_HUMAN	solute carrier family 19 (thiamine transporter), member 3	292					thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|skin(3)	30		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	AACCTGGTTAAAACCTGCTGT	0.453000													23	64					0	0	0.00188189	0	0
CYLC1	1538	broad.mit.edu	37	X	83128367	83128367	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:83128367G>A	ENST00000329312.4	+	4	688	c.651G>A	c.(649-651)aaG>aaA	p.K217K		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	217					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						TACATACAAAGAACAATCCAA	0.308000													5	29					0	0	0.000602214	0	0
FAM135B	51059	broad.mit.edu	37	8	139164294	139164294	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:139164294G>A	ENST00000395297.1	-	13	2594	c.2424C>T	c.(2422-2424)tcC>tcT	p.S808S		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	808										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			AAGATCCTGGGGAACCTTGGC	0.527000										HNSCC(54;0.14)			26	36					0	0	0.00106085	0	0
CCDC140	151278	broad.mit.edu	37	2	223169005	223169005	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:223169005C>T	ENST00000295226.1	+	2	768	c.384C>T	c.(382-384)ctC>ctT	p.L128L		NM_153038.1	NP_694583.1	Q96MF4	CC140_HUMAN	coiled-coil domain containing 140	128										endometrium(4)|large_intestine(1)|prostate(1)	6		Renal(207;0.0376)		Epithelial(121;4.03e-10)|all cancers(144;1.8e-07)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CACGTACTCTCCCGACCCCTC	0.532000													11	28					0	0	0.00244969	0	0
HERC2P3	283755	broad.mit.edu	37	15	20645802	20645802	+	RNA	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:20645802G>A	ENST00000428453.1	-	0	2963																				central_nervous_system(1)|endometrium(11)|kidney(2)|large_intestine(1)|lung(14)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	35						TCCACTGCAGGGAGCTGAGGG	0.617000													6	11					0	0	0.00116845	0	0
ALG10B	144245	broad.mit.edu	37	12	38714839	38714839	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:38714839C>T	ENST00000308742.4	+	3	1562	c.1246C>T	c.(1246-1248)Cgt>Tgt	p.R416C	ALG10B_ENST00000551464.1_Intron	NM_001013620.3	NP_001013642.1	Q5I7T1	AG10B_HUMAN	ALG10B, alpha-1,2-glucosyltransferase	416					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane|plasma membrane	dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			breast(2)|kidney(3)|large_intestine(7)|lung(8)|ovary(4)|skin(1)	25	Esophageal squamous(101;0.187)	Lung NSC(34;0.204)|all_lung(34;0.235)				GCTGGAATTTCGTTACTTCAT	0.333000													41	118					0	0	0.000781405	0	0
NIPBL	25836	broad.mit.edu	37	5	37052538	37052538	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:37052538C>T	ENST00000282516.8	+	42	7632	c.7133C>T	c.(7132-7134)cCt>cTt	p.P2378L	NIPBL_ENST00000448238.2_Missense_Mutation_p.P2378L	NM_015384.4|NM_133433.3	NP_056199.2|NP_597677.2	Q6KC79	NIPBL_HUMAN	Nipped-B homolog (Drosophila)	2378					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			autonomic_ganglia(1)|breast(4)|endometrium(9)|kidney(22)|large_intestine(21)|liver(1)|lung(47)|ovary(7)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	128	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CTAAAAGATCCTGTAAGGGGT	0.433000													18	39					0	0	0.00074312	0	0
KCNAB1	7881	broad.mit.edu	37	3	156139410	156139410	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:156139410T>C	ENST00000302490.8	+	2	1098	c.227T>C	c.(226-228)cTt>cCt	p.L76P	KCNAB1_ENST00000389634.5_Missense_Mutation_p.L76P|KCNAB1_ENST00000389636.5_Missense_Mutation_p.L94P|KCNAB1_ENST00000490337.1_Missense_Mutation_p.L94P|KCNAB1_ENST00000471742.1_Missense_Mutation_p.L83P	NM_172159.3	NP_751891.1	Q14722	KCAB1_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 1	94						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	28			LUSC - Lung squamous cell carcinoma(72;0.0461)|Lung(72;0.0465)			TATAGGAATCTTGGAAAATCA	0.463000													32	90					0	0	0.00058488	0	0
OR10J1	26476	broad.mit.edu	37	1	159410507	159410507	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:159410507C>T	ENST00000423932.3	+	1	996	c.959C>T	c.(958-960)tCc>tTc	p.S320F	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	320					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					GGGAAGTTTTCCTGACCATGT	0.493000													23	62					0	0	0.00278032	0	0
HIP1R	9026	broad.mit.edu	37	12	123335413	123335413	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:123335413C>T	ENST00000253083.4	+	6	595	c.470C>T	c.(469-471)aCa>aTa	p.T157I		NM_003959.1	NP_003950.1	O75146	HIP1R_HUMAN	huntingtin interacting protein 1 related	157					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			breast(1)|endometrium(5)|kidney(6)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	26	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		CTGGAGGTGACAGATGAGGTA	0.622000													17	57					0	0	0.00121646	0	0
TSSK4	283629	broad.mit.edu	37	14	24677292	24677292	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr14:24677292G>A	ENST00000339917.5	+	4	1161	c.957G>A	c.(955-957)gaG>gaA	p.E319E	TM9SF1_ENST00000556387.1_Intron|TM9SF1_ENST00000530611.1_Intron|TSSK4_ENST00000556621.1_Silent_p.E233E|TSSK4_ENST00000428351.2_Silent_p.E116E|TSSK4_ENST00000287913.6_Silent_p.E309E	NM_001184739.1|NM_174944.3	NP_001171668.1|NP_777604.2	Q6SA08	TSSK4_HUMAN	testis-specific serine kinase 4	309					cell differentiation|multicellular organismal development|positive regulation of CREB transcription factor activity|spermatogenesis		ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)	8				GBM - Glioblastoma multiforme(265;0.018)		GGCTGCTTGAGGCCATGTGCC	0.542000													14	27					0	0	0.00244969	0	0
EXD1	161829	broad.mit.edu	37	15	41482309	41482309	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:41482309C>T	ENST00000314992.5	-	9	898	c.708G>A	c.(706-708)tgG>tgA	p.W236*	EXD1_ENST00000458580.2_Nonsense_Mutation_p.W294*	NM_152596.2	NP_689809.2	Q8NHP7	EXD1_HUMAN	exonuclease 3'-5' domain containing 1	236					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	intracellular	3'-5' exonuclease activity|nucleic acid binding			large_intestine(5)|liver(1)|lung(4)|ovary(2)|prostate(2)|skin(2)	16						GTCGGATGAACCATACTTCTG	0.433000													54	86					0	0	0.000781405	0	0
ZCCHC5	203430	broad.mit.edu	37	X	77913245	77913245	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:77913245G>A	ENST00000321110.1	-	2	968	c.673C>T	c.(673-675)Cca>Tca	p.P225S		NM_152694.2	NP_689907.1	Q8N8U3	ZCHC5_HUMAN	zinc finger, CCHC domain containing 5	225							nucleic acid binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(18)|ovary(1)|prostate(1)|skin(1)	37						GGGGCCTGTGGAAACTCTGAA	0.507000													11	22					0	0	0.00136819	0	0
ADAM32	203102	broad.mit.edu	37	8	39114851	39114851	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:39114851C>T	ENST00000379907.4	+	19	2278	c.2151C>T	c.(2149-2151)ttC>ttT	p.F717F	ADAM32_ENST00000437682.2_Silent_p.F618F|ADAM32_ENST00000519315.1_Silent_p.F611F	NM_145004.5	NP_659441.3	Q8TC27	ADA32_HUMAN	ADAM metallopeptidase domain 32	717					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)	31		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			AAGAGGAATTCCCAAGTAGCG	0.368000													40	92					0	0	0.000781405	0	0
PLEC	5339	broad.mit.edu	37	8	144995049	144995049	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:144995049C>T	ENST00000322810.4	-	32	9520	c.9351G>A	c.(9349-9351)ctG>ctA	p.L3117L	PLEC_ENST00000354958.2_Silent_p.L2958L|PLEC_ENST00000527096.1_Silent_p.L3003L|PLEC_ENST00000354589.3_Silent_p.L2980L|PLEC_ENST00000356346.3_Silent_p.L2966L|PLEC_ENST00000436759.2_Silent_p.L3007L|PLEC_ENST00000345136.3_Silent_p.L2980L|PLEC_ENST00000357649.2_Silent_p.L2984L|PLEC_ENST00000398774.2_Silent_p.L2948L	NM_201380.2	NP_958782.1	Q15149	PLEC_HUMAN	plectin	3117	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle			NS(1)|breast(3)|central_nervous_system(4)|cervix(7)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(8)|lung(57)|ovary(4)|pancreas(2)|prostate(11)|skin(9)|stomach(2)|upper_aerodigestive_tract(10)	137						CGGCTGGCACCAGGCTGCGCA	0.642000													11	14					0	0	0.000978159	0	0
BMP3	651	broad.mit.edu	37	4	81966994	81966994	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:81966994G>A	ENST00000282701.2	+	2	739	c.419G>A	c.(418-420)gGa>gAa	p.G140E		NM_001201.2	NP_001192.2	P12645	BMP3_HUMAN	bone morphogenetic protein 3	140					cartilage development|cell differentiation|cell-cell signaling|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(6)|lung(8)|ovary(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	29						GGAGAGCTAGGAAACATCAGC	0.428000													24	71					0	0	0.00278032	0	0
KRT10	3858	broad.mit.edu	37	17	38978776	38978776	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:38978776C>T	ENST00000269576.5	-	1	71	c.62G>A	c.(61-63)gGa>gAa	p.G21E	TMEM99_ENST00000301665.3_Intron|TMEM99_ENST00000496847.1_Intron	NM_000421.3	NP_000412.3	P13645	K1C10_HUMAN	keratin 10	21	Gly-rich.|Head.				epidermis development		protein binding|structural constituent of epidermis			NS(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)	11		Breast(137;0.000301)				tcctcctcctcctcctcctcc	0.552000													9	17					0	0	0.000274275	0	0
MRGPRX1	259249	broad.mit.edu	37	11	18955401	18955401	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:18955401C>T	ENST00000302797.3	-	1	1155	c.931G>A	c.(931-933)Gaa>Aaa	p.E311K		NM_147199.3	NP_671732.3	Q96LB2	MRGX1_HUMAN	MAS-related GPR, member X1	311				EEI -> QET (in Ref. 2; AAL86880).	acute-phase response	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|pancreas(2)|prostate(3)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	36						TCCAGGATTTCCTCAGGAAGC	0.567000													9	50					0	0	0.000274275	0	0
ITGA4	3676	broad.mit.edu	37	2	182343501	182343501	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:182343501G>A	ENST00000397033.2	+	5	1004	c.574G>A	c.(574-576)Gga>Aga	p.G192R	ITGA4_ENST00000478440.1_3'UTR	NM_000885.4	NP_000876.3	P13612	ITA4_HUMAN	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)	192					blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	58			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	GAAAAAATTTGGAGAAAATTT	0.234000													6	13					0	0	0.00116845	0	0
MISP	126353	broad.mit.edu	37	19	757679	757679	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:757679G>A	ENST00000215582.6	+	2	836	c.733G>A	c.(733-735)Gtt>Att	p.V245I		NM_173481.2	NP_775752.1			mitotic spindle positioning																		CGGGCACGTGGTTCCCATCAA	0.662000													9	15					0	0	0.000978159	0	0
DCC	1630	broad.mit.edu	37	18	50731625	50731625	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr18:50731625C>T	ENST00000442544.2	+	10	2229	c.1613C>T	c.(1612-1614)tCt>tTt	p.S538F	DCC_ENST00000581580.1_Missense_Mutation_p.S193F|DCC_ENST00000412726.1_Missense_Mutation_p.S386F	NM_005215.3	NP_005206.2	P43146	DCC_HUMAN	deleted in colorectal carcinoma	538	Fibronectin type-III 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				NS(3)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(23)|liver(1)|lung(56)|ovary(7)|pancreas(3)|prostate(2)|skin(16)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(6)	148		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		CAAGCTGTATCTACCTCACCT	0.423000													50	131					0	0	0.000781405	0	0
NTNG1	22854	broad.mit.edu	37	1	107691265	107691265	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:107691265C>T	ENST00000370067.1	+	2	677	c.50C>T	c.(49-51)tCc>tTc	p.S17F	NTNG1_ENST00000370066.1_Missense_Mutation_p.S17F|NTNG1_ENST00000370072.3_Missense_Mutation_p.S17F|NTNG1_ENST00000370070.2_Missense_Mutation_p.S17F|NTNG1_ENST00000370068.1_Missense_Mutation_p.S17F|NTNG1_ENST00000370073.2_Missense_Mutation_p.S17F|NTNG1_ENST00000370071.2_Missense_Mutation_p.S17F|NTNG1_ENST00000370065.1_Missense_Mutation_p.S17F|NTNG1_ENST00000370074.4_Missense_Mutation_p.S17F|NTNG1_ENST00000370061.3_Missense_Mutation_p.S17F|NTNG1_ENST00000542803.1_Missense_Mutation_p.S17F			Q9Y2I2	NTNG1_HUMAN	netrin G1	17					axonogenesis	anchored to plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(8)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(3)|soft_tissue(1)|urinary_tract(1)	37		all_epithelial(167;1.39e-05)|all_lung(203;0.000115)|Lung NSC(277;0.000238)|Breast(1374;0.243)		Lung(183;0.0946)|BRCA - Breast invasive adenocarcinoma(282;0.237)|Epithelial(280;0.245)		GTTACGGTGTCCTCAGTGATG	0.423000													41	88					0	0	0.0025221	0	0
LRBA	987	broad.mit.edu	37	4	151392883	151392883	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:151392883G>A	ENST00000535741.1	-	43	7033	c.6560C>T	c.(6559-6561)tCa>tTa	p.S2187L	LRBA_ENST00000507224.1_Missense_Mutation_p.S2187L|LRBA_ENST00000510413.1_Missense_Mutation_p.S2187L|LRBA_ENST00000503716.1_5'UTR|LRBA_ENST00000357115.3_Missense_Mutation_p.S2198L			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	2198						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					ACTAGCTAATGAAATACGTCT	0.313000													30	61					0	0	0.00283554	0	0
ACTN2	88	broad.mit.edu	37	1	236914940	236914940	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:236914940C>T	ENST00000366578.4	+	15	1993	c.1827C>T	c.(1825-1827)acC>acT	p.T609T	ACTN2_ENST00000542672.1_Silent_p.T609T|ACTN2_ENST00000546208.1_Silent_p.T103T	NM_001103.2|NM_001278343.1	NP_001094.1|NP_001265272.1	P35609	ACTN2_HUMAN	actinin, alpha 2	609					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			endometrium(4)|kidney(2)|large_intestine(15)|lung(55)|ovary(4)|prostate(3)|skin(3)	86	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			AGCTCCGGACCAAGTGGGACA	0.567000													8	51					0	0	0.000274275	0	0
PCDHB14	56122	broad.mit.edu	37	5	140605400	140605400	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:140605400C>T	ENST00000239449.4	+	1	2323	c.2323C>T	c.(2323-2325)Caa>Taa	p.Q775*	PCDHB14_ENST00000515856.2_Nonsense_Mutation_p.Q622*	NM_018934.2	NP_061757.1	Q9Y5E9	PCDBE_HUMAN		775					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(21)|ovary(2)|prostate(3)|skin(6)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCCAATTTTCAAGTTCATGA	0.403000													16	40					0	0	0.000566183	0	0
NF1	4763	broad.mit.edu	37	17	29654621	29654621	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:29654621C>T	ENST00000358273.4	+	38	5756	c.5373C>T	c.(5371-5373)atC>atT	p.I1791I	NF1_ENST00000581113.2_3'UTR|NF1_ENST00000356175.3_Silent_p.I1770I	NM_001042492.2	NP_001035957.1	P21359	NF1_HUMAN	neurofibromin 1	1791					actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.0?(8)|p.?(3)	NF1/ACCN1(2)	autonomic_ganglia(12)|breast(11)|central_nervous_system(72)|cervix(6)|endometrium(12)|haematopoietic_and_lymphoid_tissue(59)|kidney(9)|large_intestine(39)|liver(1)|lung(80)|ovary(20)|pancreas(2)|prostate(2)|skin(8)|soft_tissue(249)|stomach(2)|thyroid(1)|upper_aerodigestive_tract(5)|urinary_tract(9)	599		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TTGAAGAAATCTGCCTAGTAG	0.448000			"""D, Mis, N, F, S, O"""		"""neurofibroma, glioma"""	"""neurofibroma, glioma"""			Neurofibromatosis, type 1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			9	70					0	0	0.000673444	0	0
BAG6	7917	broad.mit.edu	37	6	31615563	31615563	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:31615563G>A	ENST00000404765.2	-	7	882	c.593C>T	c.(592-594)cCg>cTg	p.P198L	BAG6_ENST00000375976.4_Missense_Mutation_p.P198L|BAG6_ENST00000211379.5_Missense_Mutation_p.P198L|BAG6_ENST00000439687.2_Missense_Mutation_p.P198L|BAG6_ENST00000375964.6_Missense_Mutation_p.P204L|BAG6_ENST00000362049.6_Missense_Mutation_p.P198L			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	204	Pro-rich.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding	p.P198Q(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						CGGTGGCTGCGGGGGCGGCTG	0.602000													155	337					0	0	0.000781405	0	0
COL11A2	1302	broad.mit.edu	37	6	33132137	33132137	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:33132137G>A	ENST00000341947.2	-	65	5204	c.4977C>T	c.(4975-4977)gcC>gcT	p.A1659A	COL11A2_ENST00000374708.4_Silent_p.A1573A|COL11A2_ENST00000395197.1_Silent_p.A1599A|COL11A2_ENST00000357486.1_Silent_p.A1638A|COL11A2_ENST00000361917.1_Silent_p.A1552A|COL11A2_ENST00000374714.1_Silent_p.A1633A|COL11A2_ENST00000374712.1_Silent_p.A1578A|COL11A2_ENST00000374713.1_Silent_p.A1612A|COL11A2_ENST00000477772.1_5'UTR	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	1659	Fibrillar collagen NC1.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						GACCGTCACGGGCTGCTCCAG	0.627000													4	17					0	0	0.000602214	0	0
CALD1	800	broad.mit.edu	37	7	134625906	134625906	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:134625906C>T	ENST00000361388.2	+	7	1229	c.763C>T	c.(763-765)Cga>Tga	p.R255*	CALD1_ENST00000361901.2_Nonsense_Mutation_p.R229*|CALD1_ENST00000543443.1_Nonsense_Mutation_p.R234*|CALD1_ENST00000393118.2_Nonsense_Mutation_p.R249*|CALD1_ENST00000422748.1_Nonsense_Mutation_p.R255*|CALD1_ENST00000361675.2_Nonsense_Mutation_p.R484*|CALD1_ENST00000417172.1_Nonsense_Mutation_p.R229*|CALD1_ENST00000424922.1_Nonsense_Mutation_p.R223*|CALD1_ENST00000495522.1_Nonsense_Mutation_p.R249*	NM_033138.3|NM_033157.3	NP_149129.2|NP_149347.2	Q05682	CALD1_HUMAN	caldesmon 1	484					cellular component movement|muscle contraction	cytosol|focal adhesion|myofibril	actin binding|calmodulin binding|myosin binding|tropomyosin binding	p.R484G(1)		NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(15)|lung(10)	43						CTTCATGGATCGAAAGAAGGG	0.358000													20	46					0	0	0.00152264	0	0
CSMD3	114788	broad.mit.edu	37	8	113529291	113529291	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:113529291G>A	ENST00000297405.5	-	28	4972	c.4728C>T	c.(4726-4728)ttC>ttT	p.F1576F	CSMD3_ENST00000343508.3_Silent_p.F1536F|CSMD3_ENST00000455883.2_Silent_p.F1472F|CSMD3_ENST00000352409.3_Silent_p.F1576F	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1576	Sushi 8.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TGGGCTGCCAGAAGTACCGAT	0.368000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	49					0	0	0.00209593	0	0
WDR78	79819	broad.mit.edu	37	1	67301341	67301341	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:67301341C>T	ENST00000371026.3	-	11	1756	c.1701G>A	c.(1699-1701)cgG>cgA	p.R567R	WDR78_ENST00000431318.1_Silent_p.R313R	NM_024763.4	NP_079039.4	Q5VTH9	WDR78_HUMAN	WD repeat domain 78	567										NS(1)|endometrium(3)|kidney(6)|large_intestine(6)|lung(10)|ovary(3)|skin(3)	32						TACTGTTGCTCCGTACATTGT	0.368000													23	54					0	0	0.00278032	0	0
EPPK1	83481	broad.mit.edu	37	8	144940463	144940463	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:144940463G>A	ENST00000525985.1	-	2	7030	c.6959C>T	c.(6958-6960)tCc>tTc	p.S2320F				P58107	EPIPL_HUMAN	epiplakin 1	2320						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTGGAAGAGGGAGATCTGCTG	0.706000													16	245					0	0	0.000566183	0	0
ST8SIA3	51046	broad.mit.edu	37	18	55020146	55020146	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr18:55020146G>A	ENST00000324000.3	+	1	2103	c.69G>A	c.(67-69)ctG>ctA	p.L23L		NM_015879.2	NP_056963.2	O43173	SIA8C_HUMAN	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	23					glycosphingolipid biosynthetic process|N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity			breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(16)|prostate(1)|skin(3)	36				READ - Rectum adenocarcinoma(59;0.19)|Colorectal(16;0.205)		TCGCCCTGCTGATTTTATCGC	0.602000													14	42					0	0	0.00244969	0	0
LRRC6	23639	broad.mit.edu	37	8	133584601	133584601	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:133584601C>T	ENST00000519595.1	-	12	1452	c.1354G>A	c.(1354-1356)Gaa>Aaa	p.E452K	LRRC6_ENST00000518642.1_3'UTR|LRRC6_ENST00000250173.1_Missense_Mutation_p.E452K			Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	452						cytoplasm				breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|urinary_tract(2)	34	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GTTGGGTCTTCCTCACTTGGT	0.478000													39	108					0	0	0.00148497	0	0
ATP7A	538	broad.mit.edu	37	X	77245370	77245370	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:77245370A>C	ENST00000341514.6	+	4	1407	c.1252A>C	c.(1252-1254)Act>Cct	p.T418P	ATP7A_ENST00000350425.4_Intron|ATP7A_ENST00000343533.5_Missense_Mutation_p.T418P	NM_000052.5	NP_000043.3	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	418	HMA 4.				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						TAGCAATGGGACTGTTGAGTA	0.408000													20	93					0	0	0.00152264	0	0
HOXB2	3212	broad.mit.edu	37	17	46621972	46621972	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:46621972T>C	ENST00000330070.4	-	1	1469	c.302A>G	c.(301-303)aAg>aGg	p.K101R	HOXB-AS1_ENST00000435312.1_RNA|HOXB-AS1_ENST00000504972.3_RNA	NM_002145.3	NP_002136.1	P14652	HXB2_HUMAN	homeobox B2	101					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	11						GGCGGATTTCTTCTCTTTCAT	0.692000													4	59					0	0	0.000602214	0	0
TRPM3	80036	broad.mit.edu	37	9	73240416	73240416	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:73240416G>A	ENST00000377105.1	-	13	1545	c.1191C>T	c.(1189-1191)ttC>ttT	p.F397F	TRPM3_ENST00000360823.2_Intron|TRPM3_ENST00000396285.1_Intron|TRPM3_ENST00000423814.3_Intron|TRPM3_ENST00000377110.2_Intron|TRPM3_ENST00000396292.4_Intron|TRPM3_ENST00000396280.5_Silent_p.F397F|TRPM3_ENST00000358082.3_Intron|TRPM3_ENST00000377106.1_Intron|TRPM3_ENST00000357533.2_Silent_p.F552F|TRPM3_ENST00000377111.2_Intron|TRPM3_ENST00000408909.2_Silent_p.F397F	NM_024971.5|NM_206945.3	NP_079247.5|NP_996828.3	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	569						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						AGATCCAACCGAAACCTGGAT	0.284000													16	32					0	0	0.000958276	0	0
OR6A2	8590	broad.mit.edu	37	11	6816899	6816899	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:6816899A>G	ENST00000332601.3	-	1	229	c.41T>C	c.(40-42)gTg>gCg	p.V14A		NM_003696.2	NP_003687.2	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A, member 2	14					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(4)|pancreas(1)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	29		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		GCCCAGCAACACAAACTCACT	0.507000													12	45					0	0	0.00185496	0	0
FDFT1	2222	broad.mit.edu	37	8	11667262	11667262	+	Missense_Mutation	SNP	C	C	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:11667262C>A	ENST00000220584.4	+	3	506	c.284C>A	c.(283-285)cCg>cAg	p.P95Q	FDFT1_ENST00000525777.1_Missense_Mutation_p.P10Q|FDFT1_ENST00000538689.1_5'UTR|FDFT1_ENST00000530664.1_Missense_Mutation_p.P31Q|FDFT1_ENST00000528812.1_Missense_Mutation_p.P31Q|FDFT1_ENST00000443614.2_Missense_Mutation_p.P95Q|FDFT1_ENST00000525900.1_Missense_Mutation_p.P88Q|FDFT1_ENST00000528643.1_Missense_Mutation_p.P10Q|FDFT1_ENST00000446331.2_Intron	NM_004462.3	NP_004453.3	P37268	FDFT_HUMAN	farnesyl-diphosphate farnesyltransferase 1	95					cholesterol biosynthetic process|isoprenoid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	farnesyl-diphosphate farnesyltransferase activity|oxidoreductase activity|protein binding|squalene synthase activity			breast(1)|endometrium(1)|large_intestine(3)|lung(2)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)	12	all_epithelial(15;0.234)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.18)		AAGAAGGTCCCGCTGTTACAC	0.498000													5	73					3.59834e-05	0.000175839	0.00116845	1	0
SLC35D3	340146	broad.mit.edu	37	6	137245608	137245608	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:137245608G>A	ENST00000331858.4	+	2	1190	c.1025G>A	c.(1024-1026)gGa>gAa	p.G342E		NM_001008783.1	NP_001008783.1	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	342					carbohydrate transport	integral to membrane		p.G342E(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	13	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		GGGGAGGGAGGAAATGGCCGG	0.687000													6	18					0	0	0.00116845	0	0
ANKRD28	23243	broad.mit.edu	37	3	15719851	15719851	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:15719851G>A	ENST00000399451.2	-	24	2849	c.2482C>T	c.(2482-2484)Cat>Tat	p.H828Y	ANKRD28_ENST00000497037.1_5'UTR|ANKRD28_ENST00000383777.1_Missense_Mutation_p.H861Y	NM_001195098.1|NM_001195099.1|NM_015199.3	NP_001182027.1|NP_001182028.1|NP_056014.2	O15084	ANR28_HUMAN	ankyrin repeat domain 28	828						nucleoplasm	protein binding			breast(2)|endometrium(1)|large_intestine(2)|prostate(1)	6						GCGGCTGCATGGAGAGGAGTT	0.363000													9	61					0	0	0.00136819	0	0
KRT9	3857	broad.mit.edu	37	17	39724582	39724582	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:39724582A>C	ENST00000246662.4	-	6	1291	c.1226T>G	c.(1225-1227)cTg>cGg	p.L409R	KRT9_ENST00000588431.1_Missense_Mutation_p.L176R	NM_000226.3	NP_000217.2	P35527	K1C9_HUMAN	keratin 9	409	Coil 2.|Rod.				intermediate filament organization|skin development		protein binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Breast(137;0.000307)				GATCATCTGCAGCTGGCCACA	0.512000													8	62					0	0	0.000274275	0	0
CCDC172	374355	broad.mit.edu	37	10	118137974	118137974	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:118137974G>A	ENST00000333254.3	+	8	944	c.693G>A	c.(691-693)atG>atA	p.M231I		NM_198515.2	NP_940917.1			coiled-coil domain containing 172																		AAGATGACATGGAAAGTGTTT	0.274000													25	28					0	0	0.00127121	0	0
TECTA	7007	broad.mit.edu	37	11	121008698	121008698	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:121008698C>T	ENST00000392793.1	+	11	3781	c.3510C>T	c.(3508-3510)atC>atT	p.I1170I	TECTA_ENST00000264037.2_Silent_p.I1170I			O75443	TECTA_HUMAN	tectorin alpha	1170	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GCTACAGCATCGTGATCCACC	0.562000													10	23					0	0	0.000673444	0	0
RNF133	168433	broad.mit.edu	37	7	122338165	122338165	+	Missense_Mutation	SNP	G	G	A	rs113296018	byFrequency	TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:122338165G>A	ENST00000340112.2	-	1	1045	c.808C>T	c.(808-810)Cgt>Tgt	p.R270C	CADPS2_ENST00000412584.2_Intron|CADPS2_ENST00000449022.2_Intron|CADPS2_ENST00000334010.7_Intron|CADPS2_ENST00000313070.7_Intron	NM_139175.1	NP_631914.1	Q8WVZ7	RN133_HUMAN	ring finger protein 133	270						endoplasmic reticulum membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	21						GTCAGAATACGAACTATGTCA	0.388000													66	83					0	0	0.000781405	0	0
KANSL3	55683	broad.mit.edu	37	2	97270077	97270077	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:97270077G>A	ENST00000599854.1	-	17	2265	c.1798C>T	c.(1798-1800)Cct>Tct	p.P600S	KANSL3_ENST00000431828.1_Missense_Mutation_p.P687S|KANSL3_ENST00000441706.2_Intron|KANSL3_ENST00000440133.1_Missense_Mutation_p.P507S|KANSL3_ENST00000487070.1_5'UTR	NM_001115016.2	NP_001108488.1	Q9P2N6	K1310_HUMAN	KAT8 regulatory NSL complex subunit 3	713																	ACCACTGAAGGGACTGGGCTG	0.582000													5	41					0	0	0.00116845	0	0
ASTN1	460	broad.mit.edu	37	1	176852083	176852083	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:176852083G>A	ENST00000367654.2	-	20	3311	c.3298C>T	c.(3298-3300)Cct>Tct	p.P1100S	ASTN1_ENST00000367657.3_Missense_Mutation_p.P1092S|ASTN1_ENST00000361833.2_Missense_Mutation_p.P1092S|ASTN1_ENST00000424564.2_Missense_Mutation_p.P1092S			O14525	ASTN1_HUMAN	astrotactin 1	1100	Fibronectin type-III 1.				cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						ATTGCACAAGGAGACTTTGCT	0.493000													22	99					0	0	0.00229938	0	0
ARHGAP24	83478	broad.mit.edu	37	4	86916055	86916055	+	Silent	SNP	C	C	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:86916055C>A	ENST00000395184.1	+	9	1714	c.1248C>A	c.(1246-1248)ccC>ccA	p.P416P	ARHGAP24_ENST00000264343.4_Silent_p.P323P|ARHGAP24_ENST00000395183.2_Silent_p.P321P	NM_001025616.2	NP_001020787.2	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24	416					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding			breast(3)|cervix(1)|endometrium(3)|large_intestine(4)|lung(10)|skin(1)|stomach(1)|urinary_tract(1)	24		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		CTAGAAGCCCCCCTCTCATGG	0.478000													6	161					0.00116845	0.00566261	0.00116845	1	0
OR5F1	338674	broad.mit.edu	37	11	55761196	55761196	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:55761196C>T	ENST00000278409.1	-	1	905	c.906G>A	c.(904-906)gcG>gcA	p.A302A		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					TAATTACATTCGCTAAAGCCT	0.383000													11	21					0	0	0.00136819	0	0
VIL1	7429	broad.mit.edu	37	2	219301212	219301212	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:219301212G>A	ENST00000248444.5	+	16	1922	c.1834G>A	c.(1834-1836)Gaa>Aaa	p.E612K	VIL1_ENST00000392114.2_Missense_Mutation_p.E301K	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	612	Core.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGACTACAGGAAGAAAACCT	0.512000													62	143					0	0	0.000781405	0	0
PTPRK	5796	broad.mit.edu	37	6	128294914	128294914	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:128294914C>T	ENST00000368227.3	-	29	4445	c.4079G>A	c.(4078-4080)cGa>cAa	p.R1360Q	PTPRK_ENST00000368215.3_Missense_Mutation_p.R1342Q|PTPRK_ENST00000368213.5_Missense_Mutation_p.R1349Q|PTPRK_ENST00000368226.4_Missense_Mutation_p.R1343Q|PTPRK_ENST00000532331.1_Missense_Mutation_p.R1365Q|PTPRK_ENST00000368207.3_Missense_Mutation_p.R1375Q|PTPRK_ENST00000368210.3_Missense_Mutation_p.R1361Q			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1342	Tyrosine-protein phosphatase 2.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		AGGCACTTCTCGATGAGAAGC	0.478000													21	65					0	0	0.00152264	0	0
AOAH	313	broad.mit.edu	37	7	36570058	36570058	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:36570058G>A	ENST00000431169.1	-	19	1788	c.1488C>T	c.(1486-1488)ttC>ttT	p.F496F	AOAH_ENST00000538464.1_Silent_p.F218F|AOAH_ENST00000535891.1_Silent_p.F464F|AOAH_ENST00000258749.5_Silent_p.F496F|AOAH_ENST00000491444.1_5'UTR	NM_001177506.1	NP_001170977.1	P28039	AOAH_HUMAN	acyloxyacyl hydrolase (neutrophil)	496					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(21)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	41						AGAAAAGATTGAAGTTTGTAA	0.403000													19	41					0	0	0.00152264	0	0
DOCK11	139818	broad.mit.edu	37	X	117739215	117739215	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:117739215G>A	ENST00000276204.6	+	24	2651	c.2577G>A	c.(2575-2577)atG>atA	p.M859I	DOCK11_ENST00000276202.7_Missense_Mutation_p.M859I			Q5JSL3	DOC11_HUMAN	dedicator of cytokinesis 11	859	DHR-1.				blood coagulation	cytosol	GTP binding			breast(4)|cervix(2)|endometrium(8)|kidney(5)|large_intestine(17)|liver(1)|lung(35)|ovary(4)|prostate(3)|skin(3)|stomach(1)|urinary_tract(1)	84						TGCATGCCATGGAGATCCAAG	0.328000													17	130					0	0	0.00074312	0	0
SYNGR4	23546	broad.mit.edu	37	19	48879000	48879000	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:48879000C>T	ENST00000344846.2	+	4	712	c.462C>T	c.(460-462)atC>atT	p.I154I	SYNGR4_ENST00000601610.1_Silent_p.I105I|SYNGR4_ENST00000595322.1_Intron	NM_012451.3	NP_036583.2	O95473	SNG4_HUMAN	synaptogyrin 4	154	MARVEL.					integral to membrane				breast(1)|endometrium(2)|large_intestine(4)|lung(2)|skin(1)	10		all_epithelial(76;5.08e-07)|all_lung(116;5.76e-06)|Lung NSC(112;1.18e-05)|Prostate(7;0.0143)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000138)|all cancers(93;0.00017)|Epithelial(262;0.0138)|GBM - Glioblastoma multiforme(486;0.0146)		TCTTCTCCATCCTTGTCTGGG	0.602000													17	47					0	0	0.00121646	0	0
LILRA5	353514	broad.mit.edu	37	19	54822811	54822811	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:54822811G>A	ENST00000301219.3	-	5	704	c.585C>T	c.(583-585)ttC>ttT	p.F195F	AC008984.2_ENST00000507363.1_RNA|LILRA5_ENST00000346508.3_Silent_p.F183F|LILRA5_ENST00000432233.3_Silent_p.F195F|LILRA5_ENST00000446712.3_Silent_p.F183F	NM_021250.2	NP_067073.1	A6NI73	LIRA5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5	195	Ig-like C2-type 2.				innate immune response	extracellular region|integral to membrane	receptor activity			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACAGGGCCTGGAACTGCCCAC	0.592000													8	33					0	0	0.000274275	0	0
SNCAIP	9627	broad.mit.edu	37	5	121759022	121759022	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:121759022C>T	ENST00000261367.7	+	6	2159	c.731C>T	c.(730-732)tCt>tTt	p.S244F	SNCAIP_ENST00000504884.2_Intron|SNCAIP_ENST00000503116.2_Missense_Mutation_p.S244F|SNCAIP_ENST00000414317.2_Intron|SNCAIP_ENST00000379533.2_Missense_Mutation_p.S244F|SNCAIP_ENST00000261368.8_Missense_Mutation_p.S197F|SNCAIP_ENST00000542191.1_Intron|SNCAIP_ENST00000379538.3_Intron|SNCAIP_ENST00000379536.2_Missense_Mutation_p.S197F			Q9Y6H5	SNCAP_HUMAN	synuclein, alpha interacting protein	197					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			NS(3)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	39		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		ACAGGAAGTTCTGAGAGCTCA	0.463000													45	53					0	0	0.0025221	0	0
ATM	472	broad.mit.edu	37	11	108213955	108213955	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:108213955C>T	ENST00000278616.4	+	57	8660	c.8275C>T	c.(8275-8277)Ccc>Tcc	p.P2759S	C11orf65_ENST00000526725.1_Intron|C11orf65_ENST00000525729.1_Intron|ATM_ENST00000452508.2_Missense_Mutation_p.P2759S	NM_000051.3	NP_000042.3	Q13315	ATM_HUMAN	ataxia telangiectasia mutated	2759	PI3K/PI4K.				cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			NS(4)|breast(23)|central_nervous_system(11)|endometrium(10)|haematopoietic_and_lymphoid_tissue(227)|kidney(19)|large_intestine(53)|liver(5)|lung(62)|ovary(6)|pancreas(4)|prostate(13)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	448		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		CCAGGTGGTTCCCCTCTCTCA	0.388000			"""D, Mis, N, F, S"""		T-PLL	"""leukemia, lymphoma, medulloblastoma, glioma"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Ataxia Telangiectasia	TSP Lung(14;0.12)			44	70					0	0	0.000781405	0	0
MUC16	94025	broad.mit.edu	37	19	9091671	9091671	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:9091671G>A	ENST00000397910.4	-	1	347	c.144C>T	c.(142-144)atC>atT	p.I48I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	48	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTGTCACCACGATTGCACCTG	0.517000													14	36					0	0	0.00244969	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:140453136A>T	ENST00000288602.6	-	15	1859	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333.4	NP_004324.2	P15056	BRAF_HUMAN	v-raf murine sarcoma viral oncogene homolog B	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(15453)|p.V600K(252)|p.V600R(44)|p.V600D(16)|p.V600A(12)|p.V600_K601>E(12)|p.V600G(11)|p.T599_R603>I(2)|p.V600Q(2)|p.V600_S605>EK(1)|p.V600_S605>DV(1)|p.V600_S605>D(1)|p.T599_V600insDFGLAT(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				45	45					0	0	0.000781405	0	0
PUF60	22827	broad.mit.edu	37	8	144898899	144898899	+	Missense_Mutation	SNP	C	C	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:144898899C>A	ENST00000526683.1	-	12	2026	c.1471G>T	c.(1471-1473)Ggg>Tgg	p.G491W	PUF60_ENST00000527197.1_Missense_Mutation_p.G445W|PUF60_ENST00000456095.2_Missense_Mutation_p.G462W|PUF60_ENST00000453551.2_Missense_Mutation_p.G448W|PUF60_ENST00000313352.7_Missense_Mutation_p.G431W|PUF60_ENST00000349157.6_Missense_Mutation_p.G474W	NM_001271098.1|NM_078480.1	NP_001258027.1|NP_510965.1	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa	491	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.|RRM 3; atypical.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding	p.G491W(1)		NS(1)|endometrium(1)|kidney(3)|lung(7)|prostate(2)	14	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			TTCACGGCCCCGAACTTGCCA	0.527000													6	201					0.00198382	0.00948867	0.00198382	1	0
CD180	4064	broad.mit.edu	37	5	66479863	66479863	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:66479863C>T	ENST00000256447.4	-	3	965	c.808G>A	c.(808-810)Gga>Aga	p.G270R		NM_005582.2	NP_005573.2	Q99467	CD180_HUMAN	CD180 molecule	270					inflammatory response|innate immune response	integral to membrane|plasma membrane	receptor activity			cervix(1)|endometrium(2)|kidney(7)|large_intestine(12)|liver(1)|lung(8)|ovary(1)|stomach(2)	34		Lung NSC(167;4.94e-05)|Prostate(74;0.00601)|Ovarian(174;0.0654)|Breast(144;0.198)|Colorectal(97;0.234)		Lung(70;0.0046)		TCACAGAGTCCCTTGAGCATG	0.453000													14	19					0	0	0.000566183	0	0
OR10H5	284433	broad.mit.edu	37	19	15905608	15905608	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:15905608C>T	ENST00000308940.8	+	1	848	c.750C>T	c.(748-750)gtC>gtT	p.V250V		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	250					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						CTGTGGTGGTCGTGCACTATG	0.562000													6	20					0	0	0.000274275	0	0
CHTF8	54921	broad.mit.edu	37	16	69154547	69154547	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:69154547G>A	ENST00000519520.1	-	3	164	c.29C>T	c.(28-30)tCc>tTc	p.S10F	CHTF8_ENST00000520529.1_Missense_Mutation_p.S10F|CHTF8_ENST00000518041.1_Intron|CHTF8_ENST00000306585.6_5'UTR|CHTF8_ENST00000523421.1_Intron|CHTF8_ENST00000448552.2_Silent_p.I49I|CHTF8_ENST00000398235.2_Silent_p.I49I|CHTF8_ENST00000522091.1_3'UTR			P0CG13	CTF8_HUMAN	CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae)	0					cell cycle|DNA replication	nucleus	DNA binding										TCAGCACAGGGATTCCCTTTG	0.527000													19	39					0	0	0.00229938	0	0
DSG3	1830	broad.mit.edu	37	18	29046579	29046579	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr18:29046579G>A	ENST00000257189.4	+	11	1581	c.1498G>A	c.(1498-1500)Gat>Aat	p.D500N		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	500					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CCTCGAAAAAGATGCAGTTTG	0.428000													40	100					0	0	0.00128727	0	0
SYNJ1	8867	broad.mit.edu	37	21	34072313	34072313	+	Missense_Mutation	SNP	G	G	A	rs146507597		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr21:34072313G>A	ENST00000382499.2	-	4	430	c.431C>T	c.(430-432)tCa>tTa	p.S144L	SYNJ1_ENST00000433931.2_Missense_Mutation_p.S144L|SYNJ1_ENST00000382491.3_Missense_Mutation_p.S105L|SYNJ1_ENST00000357345.3_Missense_Mutation_p.S105L|SYNJ1_ENST00000322229.7_Missense_Mutation_p.S105L	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	105	SAC.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						GATTCGCAGTGATATAAACTC	0.383000													20	27					0	0	0.000958276	0	0
TBX15	6913	broad.mit.edu	37	1	119466105	119466105	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:119466105A>T	ENST00000369429.3	-	5	824	c.815T>A	c.(814-816)tTt>tAt	p.F272Y	TBX15_ENST00000207157.3_Missense_Mutation_p.F166Y			Q96SF7	TBX15_HUMAN	T-box 15	272						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		AGTCTCAGGAAAGTTGAACGT	0.483000													18	32					0	0	0.00074312	0	0
GOLGA6A	342096	broad.mit.edu	37	15	74368313	74368313	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:74368313C>T	ENST00000290438.3	-	8	618	c.578G>A	c.(577-579)aGa>aAa	p.R193K		NM_001038640.2	NP_001033729.2	Q9NYA3	GOG6A_HUMAN	golgin A6 family, member A	193										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|liver(1)|lung(6)|prostate(1)|urinary_tract(1)	16						GACCGCTTCTCTGCAGCTCGA	0.562000													21	103					0	0	0.000586117	0	0
TREML2	79865	broad.mit.edu	37	6	41162268	41162268	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:41162268G>A	ENST00000483722.1	-	3	865	c.680C>T	c.(679-681)tCc>tTc	p.S227F		NM_024807.2	NP_079083.2	Q5T2D2	TRML2_HUMAN	triggering receptor expressed on myeloid cells-like 2	227					T cell activation	cell surface|integral to membrane|plasma membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(13)|ovary(1)|prostate(1)	18	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGTGGAGATGGATTCTGGGCC	0.627000													9	17					0	0	0.000442599	0	0
TNXB	7148	broad.mit.edu	37	6	32013006	32013006	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:32013006G>A	ENST00000375244.3	-	32	10905	c.10704C>T	c.(10702-10704)acC>acT	p.T3568T	TNXB_ENST00000375247.2_Silent_p.T3566T|TNXB_ENST00000451343.1_5'UTR			P22105	TENX_HUMAN	tenascin XB	3613	Fibronectin type-III 27.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TGGAGTCTGGGGTTGTGTCGG	0.652000													46	281					0	0	0.000781405	0	0
ZNF215	7762	broad.mit.edu	37	11	6977047	6977047	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:6977047G>A	ENST00000278319.5	+	7	1427	c.839G>A	c.(838-840)tGg>tAg	p.W280*	ZNF215_ENST00000414517.2_Nonsense_Mutation_p.W280*|ZNF215_ENST00000527171.1_3'UTR|ZNF215_ENST00000529903.1_Intron	NM_013250.2	NP_037382.2	Q9UL58	ZN215_HUMAN	zinc finger protein 215	280					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(4)	32				Epithelial(150;6.33e-08)|BRCA - Breast invasive adenocarcinoma(625;0.134)		CAGAAAAAATGGGACATAAAT	0.378000													37	60					0	0	0.00111076	0	0
EPS15L1	58513	broad.mit.edu	37	19	16488050	16488050	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:16488050G>A	ENST00000455140.2	-	22	2329	c.2263C>T	c.(2263-2265)Cct>Tct	p.P755S	EPS15L1_ENST00000248070.6_Missense_Mutation_p.P755S|EPS15L1_ENST00000535753.2_Intron|EPS15L1_ENST00000594975.1_Intron	NM_001258374.1	NP_001245303.1	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway substrate 15-like 1	755	15 X 3 AA repeats of D-P-F.|Pro-rich.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(3)|lung(12)|ovary(4)|skin(2)	30						GAGGTGAAAGGGCCAGAAGGT	0.512000											OREG0025332	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	81					0	0	0.00121646	0	0
DDX53	168400	broad.mit.edu	37	X	23018769	23018769	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:23018769G>A	ENST00000327968.5	+	1	683	c.595G>A	c.(595-597)Gaa>Aaa	p.E199K	RP11-40F8.2_ENST00000455399.1_RNA	NM_182699.3	NP_874358.2	Q86TM3	DDX53_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	199						nucleus	ATP binding|ATP-dependent helicase activity|RNA binding			breast(2)|endometrium(5)|kidney(4)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	35						CTGGAGAAAGGAAAATTTCAA	0.388000													36	86					0	0	0.00148497	0	0
FRMPD2	143162	broad.mit.edu	37	10	49386119	49386119	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:49386119C>T	ENST00000374201.3	-	22	3168	c.2866G>A	c.(2866-2868)Gaa>Aaa	p.E956K	FRMPD2_ENST00000407470.4_Missense_Mutation_p.E924K|FRMPD2_ENST00000463706.1_5'UTR|FRMPD2_ENST00000305531.3_Missense_Mutation_p.E931K	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	956	PDZ 2.				tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		GTCCCATCTTCTTTAACCAGT	0.428000													5	15					0	0	0.000274275	0	0
CR2	1380	broad.mit.edu	37	1	207643060	207643060	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:207643060C>T	ENST00000367057.3	+	6	1027	c.838C>T	c.(838-840)Ccc>Tcc	p.P280S	CR2_ENST00000367059.3_Missense_Mutation_p.P280S|CR2_ENST00000485707.1_3'UTR|CR2_ENST00000367058.3_Missense_Mutation_p.P280S|CR2_ENST00000458541.2_Missense_Mutation_p.P280S	NM_001006658.2	NP_001006659.1	P20023	CR2_HUMAN	complement component (3d/Epstein Barr virus) receptor 2	280	Sushi 5.				complement activation, classical pathway|innate immune response	integral to membrane|plasma membrane	complement receptor activity|protein homodimerization activity			NS(2)|breast(3)|endometrium(4)|kidney(3)|large_intestine(12)|lung(26)|ovary(1)|pancreas(1)|prostate(1)|skin(12)|upper_aerodigestive_tract(3)|urinary_tract(1)	69						CCCATCACCTCCCCCTATTCT	0.433000													15	71					0	0	0.000566183	0	0
ANK2	287	broad.mit.edu	37	4	114275410	114275410	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:114275410C>T	ENST00000357077.4	+	38	5689	c.5636C>T	c.(5635-5637)tCa>tTa	p.S1879L	ANK2_ENST00000506722.1_Intron|ANK2_ENST00000509550.1_Intron|ANK2_ENST00000264366.6_Missense_Mutation_p.S1846L|ANK2_ENST00000394537.3_Intron|ANK2_ENST00000510275.2_Intron	NM_001148.4	NP_001139.3	Q01484	ANK2_HUMAN	ankyrin 2, neuronal	1846	Repeat-rich region.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding			NS(1)|biliary_tract(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(54)|liver(2)|lung(112)|ovary(8)|pancreas(1)|prostate(7)|skin(11)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(10)	248		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		GAGAAACACTCACCTGTATCA	0.443000													48	102					0	0	0.000781405	0	0
PDE4DIP	9659	broad.mit.edu	37	1	145075723	145075723	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:145075723G>A	ENST00000369359.4	-	1	178	c.140C>T	c.(139-141)cCg>cTg	p.P47L	PDE4DIP_ENST00000369348.3_Missense_Mutation_p.P47L|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.P47L|PDE4DIP_ENST00000369345.4_Missense_Mutation_p.P47L			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTCCCGGCTCGGGGTCTGCCG	0.716000			T	PDGFRB	MPD								10	99					0	0	0.000673444	0	0
PEG3	5178	broad.mit.edu	37	19	57335917	57335917	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:57335917C>T	ENST00000326441.9	-	4	470	c.107G>A	c.(106-108)gGa>gAa	p.G36E	PEG3_ENST00000593695.1_Intron|ZIM2_ENST00000593711.1_Intron|PEG3_ENST00000423103.2_Missense_Mutation_p.G36E|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000599935.1_Intron|PEG3_ENST00000598410.1_Intron|ZIM2_ENST00000221722.5_Intron|PEG3_ENST00000594706.1_Intron	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	36					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		TGGACCTTCTCCTATGATGAC	0.478000													23	50					0	0	0.00188189	0	0
LTBP4	8425	broad.mit.edu	37	19	41132981	41132981	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:41132981C>T	ENST00000308370.7	+	32	4285	c.4285C>T	c.(4285-4287)Cca>Tca	p.P1429S	LTBP4_ENST00000243562.9_3'UTR|LTBP4_ENST00000545697.1_Missense_Mutation_p.P797S|LTBP4_ENST00000602240.1_3'UTR|LTBP4_ENST00000396819.3_Missense_Mutation_p.P1362S|LTBP4_ENST00000204005.9_Missense_Mutation_p.P1392S	NM_001042544.1	NP_001036009.1	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	1430	Pro-rich.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGACTTAGGTCCACCTTACCA	0.657000													7	13					0	0	0.00198382	0	0
ZNF75D	7626	broad.mit.edu	37	X	134426375	134426375	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:134426375C>T	ENST00000370766.3	-	4	3145	c.436G>A	c.(436-438)Gag>Aag	p.E146K	ZNF75D_ENST00000370764.1_Intron|ZNF75D_ENST00000494295.1_Intron	NM_007131.3	NP_009062.2	P51815	ZN75D_HUMAN	zinc finger protein 75D	146					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(14)|upper_aerodigestive_tract(1)|urinary_tract(2)	31						AGCACTGCCTCCTTTCCCAGC	0.512000													13	75					0	0	0.000566183	0	0
SIGIRR	59307	broad.mit.edu	37	11	408110	408110	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:408110C>T	ENST00000431843.2	-	4	609	c.303G>A	c.(301-303)caG>caA	p.Q101Q	SIGIRR_ENST00000531205.1_Silent_p.Q101Q|SIGIRR_ENST00000529486.1_5'UTR|SIGIRR_ENST00000397632.3_Silent_p.Q101Q|SIGIRR_ENST00000382520.2_Silent_p.Q101Q|SIGIRR_ENST00000332725.3_Silent_p.Q101Q	NM_001135054.1	NP_001128526.1	Q6IA17	SIGIR_HUMAN	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	101	Ig-like C2-type.				acute-phase response|innate immune response|negative regulation of chemokine biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of lipopolysaccharide-mediated signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity	integral to membrane	protein binding|transmembrane receptor activity			cervix(2)|endometrium(1)|liver(1)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	13		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGCTGATGTTCTGGATGGAGC	0.582000													14	76					0	0	0.000308642	0	0
MYO5B	4645	broad.mit.edu	37	18	47402197	47402197	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr18:47402197C>T	ENST00000285039.7	-	26	3696	c.3396_splice	c.e26-1	p.E1133_splice	MYO5B_ENST00000587895.1_5'UTR|MYO5B_ENST00000324581.6_Splice_Site_p.E274_splice	NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	1133					protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		AGGCCAATTTCCTTCAAAGGA	0.498000													23	74					0	0	0.000720815	0	0
HRH4	59340	broad.mit.edu	37	18	22056862	22056862	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr18:22056862C>T	ENST00000256906.4	+	3	609	c.509C>T	c.(508-510)tCg>tTg	p.S170L	HRH4_ENST00000426880.2_Missense_Mutation_p.S82L	NM_001160166.1|NM_021624.3	NP_001153638.1|NP_067637.2	Q9H3N8	HRH4_HUMAN	histamine receptor H4	170						integral to membrane|plasma membrane	histamine receptor activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|ovary(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	GGATTTTTTTCGGAATGGTAC	0.433000													33	93					0	0	0.000692331	0	0
DISP1	84976	broad.mit.edu	37	1	223178084	223178084	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:223178084C>T	ENST00000284476.6	+	8	3509	c.3345C>T	c.(3343-3345)atC>atT	p.I1115I		NM_032890.3	NP_116279.2	Q96F81	DISP1_HUMAN	dispatched homolog 1 (Drosophila)	1115					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(20)|lung(25)|prostate(4)|skin(1)|stomach(1)|urinary_tract(5)	69				GBM - Glioblastoma multiforme(131;0.102)		TGATGCTCATCATGTGTATCA	0.542000													385	447					0	0	0.000781405	0	0
UNC13C	440279	broad.mit.edu	37	15	54792317	54792317	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:54792317G>A	ENST00000545554.1	+	20	5101	c.5101G>A	c.(5101-5103)Gaa>Aaa	p.E1701K	UNC13C_ENST00000260323.11_Missense_Mutation_p.E1701K|UNC13C_ENST00000537900.1_Missense_Mutation_p.E1699K			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1701	MHD1.				exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AGATGAAAACGAAGATGTGTC	0.348000													10	25					0	0	0.00244969	0	0
SLC34A2	10568	broad.mit.edu	37	4	25678062	25678062	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:25678062G>A	ENST00000382051.3	+	13	1814	c.1764G>A	c.(1762-1764)caG>caA	p.Q588Q	SLC34A2_ENST00000504570.1_Silent_p.Q587Q|SLC34A2_ENST00000503434.1_Silent_p.Q587Q	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	588					cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				AGAAACTCCAGAACTGGAACT	0.612000			T	ROS1	NSCLC								38	91					0	0	0.0025221	0	0
PLCB1	23236	broad.mit.edu	37	20	8717789	8717789	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:8717789G>A	ENST00000378641.3	+	20	2633	c.2158G>A	c.(2158-2160)Gga>Aga	p.G720R	PLCB1_ENST00000378637.2_Missense_Mutation_p.G720R|PLCB1_ENST00000494924.1_3'UTR|PLCB1_ENST00000338037.6_Missense_Mutation_p.G720R	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	720	C2.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						AACATCCCAAGGAAATGCTGT	0.388000													20	56					0	0	0.00188189	0	0
PAK6	56924	broad.mit.edu	37	15	40557141	40557141	+	Missense_Mutation	SNP	C	C	T	rs146905959		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:40557141C>T	ENST00000455577.2	+	4	1067	c.155C>T	c.(154-156)cCc>cTc	p.P52L	PAK6_ENST00000441369.1_Missense_Mutation_p.P52L|PAK6_ENST00000260404.4_Missense_Mutation_p.P52L|PAK6_ENST00000542403.2_Missense_Mutation_p.P52L|RP11-133K1.2_ENST00000558658.1_Missense_Mutation_p.P146S|PAK6_ENST00000453867.1_Missense_Mutation_p.P52L|PAK6_ENST00000560346.1_Missense_Mutation_p.P52L	NM_001276718.1	NP_001263647.1	Q9NQU5	PAK6_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 6	52	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity	p.P52L(1)		breast(1)|cervix(1)|endometrium(3)|large_intestine(2)|liver(1)|lung(11)|ovary(2)|prostate(1)|skin(2)	24		all_cancers(109;1.13e-18)|all_epithelial(112;1.62e-15)|Lung NSC(122;5.67e-11)|all_lung(180;1.41e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0823)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.51e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0544)		CGCCCCAAGCCCGTGGTGGAC	0.617000													19	40					0	0	0.00188189	0	0
DENND2A	27147	broad.mit.edu	37	7	140301538	140301538	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:140301538C>T	ENST00000275884.6	-	2	1077	c.660G>A	c.(658-660)tcG>tcA	p.S220S	DENND2A_ENST00000537639.1_Silent_p.S220S|DENND2A_ENST00000492720.1_Silent_p.S220S|DENND2A_ENST00000496613.1_Silent_p.S220S			Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	220										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(22)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	49	Melanoma(164;0.00956)					CTTCCAGGTCCGAGGGGTGGA	0.637000													69	78					0	0	0.000781405	0	0
TMED1	11018	broad.mit.edu	37	19	10943869	10943869	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:10943869C>T	ENST00000591695.1	-	3	428	c.302G>A	c.(301-303)gGa>gAa	p.G101E	TMED1_ENST00000214869.2_Silent_p.R162R|TMED1_ENST00000588289.1_Silent_p.R17R			Q13445	TMED1_HUMAN	transmembrane emp24 protein transport domain containing 1	0	GOLD.				cell-cell signaling|signal transduction|transport	integral to membrane|plasma membrane	receptor binding			breast(1)|central_nervous_system(2)|lung(2)|ovary(3)|prostate(1)|skin(1)	10						CCAGCCGGGTCCGCATGGTCT	0.627000													6	7					0	0	0.00116845	0	0
TTN	7273	broad.mit.edu	37	2	179489390	179489390	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:179489390C>T	ENST00000589042.1	-	242	44841	c.44617G>A	c.(44617-44619)Gag>Aag	p.E14873K	TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.E13232K|TTN_ENST00000359218.5_Missense_Mutation_p.E5933K|TTN_ENST00000460472.2_Missense_Mutation_p.E5808K|TTN_ENST00000342175.6_Missense_Mutation_p.E6000K|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.E12305K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	13232	Fibronectin type-III 7.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACTTCACACTCCAGCACTGCA	0.453000													31	58					0	0	0.001512	0	0
NLRP14	338323	broad.mit.edu	37	11	7063998	7063998	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:7063998C>T	ENST00000299481.4	+	4	1087	c.741C>T	c.(739-741)atC>atT	p.I247I		NM_176822.3	NP_789792.1	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	247	NACHT.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			breast(3)|large_intestine(7)|lung(1)|ovary(3)|pancreas(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	21				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TTGAAGAAATCATGTACCAGC	0.433000													19	53					0	0	0.00121646	0	0
SH3KBP1	30011	broad.mit.edu	37	X	19568112	19568112	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:19568112G>A	ENST00000397821.3	-	14	1764	c.1474C>T	c.(1474-1476)Ccg>Tcg	p.P492S	SH3KBP1_ENST00000541422.1_Missense_Mutation_p.P231S|SH3KBP1_ENST00000379698.4_Missense_Mutation_p.P455S|SH3KBP1_ENST00000379716.1_Missense_Mutation_p.P254S	NM_031892.2	NP_114098.1	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1	492					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(8)|skin(4)	29						GACTGGGACGGAGGCCGCCTC	0.463000													26	165					0	0	0.00178596	0	0
SLC4A1	6521	broad.mit.edu	37	17	42336949	42336949	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:42336949C>T	ENST00000262418.6	-	8	765	c.609_splice	c.e8-1	p.G204_splice	AC003043.1_ENST00000597382.1_Intron	NM_000342.3	NP_000333.1	P02730	B3AT_HUMAN	solute carrier family 4 (anion exchanger), member 1	204					bicarbonate transport|cellular ion homeostasis	basolateral plasma membrane|cortical cytoskeleton|integral to plasma membrane|Z disc	ankyrin binding|chloride transmembrane transporter activity|inorganic anion exchanger activity|protein anchor|protein homodimerization activity			central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|prostate(3)|skin(1)|urinary_tract(1)	40		Breast(137;0.014)|Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.115)		CCCCCATCTCCCTGTGGGAAG	0.587000													7	26					0	0	0.000157383	0	0
DENND3	22898	broad.mit.edu	37	8	142204174	142204174	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:142204174G>A	ENST00000519811.1	+	23	3749	c.3679G>A	c.(3679-3681)Ggg>Agg	p.G1227R	DENND3_ENST00000523308.1_Missense_Mutation_p.G197R|DENND3_ENST00000424248.1_Missense_Mutation_p.G1095R|DENND3_ENST00000262585.2_Missense_Mutation_p.G1147R			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	1147										breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			AACACCCAAGGGGAAAATCTA	0.627000													21	62					0	0	0.00047179	0	0
FAM47E-STBD1	100631383	broad.mit.edu	37	4	77231024	77231024	+	Missense_Mutation	SNP	T	T	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:77231024T>G	ENST00000237642.6	+	2	1692	c.948T>G	c.(946-948)gaT>gaG	p.D316E	FAM47E_ENST00000515604.1_3'UTR|FAM47E-STBD1_ENST00000539752.1_Missense_Mutation_p.D167E	NM_003943.4	NP_003934.1																					TGCCTGCAGATACAGTGGTGG	0.473000													17	73					0	0	0.00074312	0	0
MROH7	374977	broad.mit.edu	37	1	55138821	55138821	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:55138821G>A	ENST00000414150.2	+	8	1935	c.1657G>A	c.(1657-1659)Gag>Aag	p.E553K	MROH7_ENST00000545244.1_Missense_Mutation_p.E121K|MROH7_ENST00000421030.2_Missense_Mutation_p.E553K|MROH7_ENST00000454855.2_Missense_Mutation_p.E71K|MROH7_ENST00000409996.1_Missense_Mutation_p.E121K|MROH7_ENST00000395690.2_Missense_Mutation_p.E553K|MROH7_ENST00000339553.5_Missense_Mutation_p.E553K					maestro heat-like repeat family member 7																		CCTCTTTATCGAGGACCCCAC	0.592000													18	30					0	0	0.00152264	0	0
SORL1	6653	broad.mit.edu	37	11	121424794	121424794	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:121424794C>T	ENST00000260197.7	+	17	2544	c.2415C>T	c.(2413-2415)tcC>tcT	p.S805S		NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	805					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TGTATTGGTCCGACCTGGCCT	0.587000													16	17					0	0	0.000566183	0	0
RFX2	5990	broad.mit.edu	37	19	6040210	6040210	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:6040210G>A	ENST00000303657.5	-	5	452	c.303C>T	c.(301-303)gcC>gcT	p.A101A	RFX2_ENST00000359161.3_Silent_p.A101A|RFX2_ENST00000592546.1_Silent_p.A101A	NM_000635.3	NP_000626.2	P48378	RFX2_HUMAN	regulatory factor X, 2 (influences HLA class II expression)	101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(4)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						TGCTGCTGGGGGCGTACATCT	0.612000													29	81					0	0	0.00178596	0	0
ZNF732	654254	broad.mit.edu	37	4	289909	289909	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:289909G>A	ENST00000419098.1	-	2	49	c.39C>T	c.(37-39)ttC>ttT	p.F13F		NM_001137608.1	NP_001131080.1	B4DXR9	ZN732_HUMAN	zinc finger protein 732	13	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|lung(2)	3						CTTCTGGAGAGAATTCTATGG	0.418000													10	36					0	0	0.000978159	0	0
FOXF1	2294	broad.mit.edu	37	16	86544358	86544358	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:86544358C>T	ENST00000262426.4	+	1	226	c.183C>T	c.(181-183)atC>atT	p.I61I		NM_001451.2	NP_001442.2	Q12946	FOXF1_HUMAN	forkhead box F1	61					branching involved in open tracheal system development|cardiac left ventricle morphogenesis|embryonic ectodermal digestive tract morphogenesis|endocardial cushion development|in utero embryonic development|lung vasculature development|midgut development|pancreas development|positive regulation of transcription, DNA-dependent|regulation of sequence-specific DNA binding transcription factor activity|ureter development|venous blood vessel development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|lung(4)|ovary(1)|urinary_tract(1)	12						TCATGGCCATCCAGAGTTCAC	0.642000													12	28					0	0	0.00185496	0	0
FAAH2	158584	broad.mit.edu	37	X	57318998	57318998	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:57318998G>A	ENST00000374900.4	+	2	380	c.260G>A	c.(259-261)gGa>gAa	p.G87E		NM_174912.3	NP_777572.2	Q6GMR7	FAAH2_HUMAN	fatty acid amide hydrolase 2	87						integral to membrane	carbon-nitrogen ligase activity, with glutamine as amido-N-donor|hydrolase activity			endometrium(2)|large_intestine(4)|lung(10)|ovary(3)|upper_aerodigestive_tract(3)	22						ATGATCAATGGAATTGTCAAG	0.393000										HNSCC(52;0.14)			33	41					0	0	0.00209593	0	0
HEPH	9843	broad.mit.edu	37	X	65412096	65412096	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:65412096G>A	ENST00000519389.1	+	7	1529	c.1350G>A	c.(1348-1350)atG>atA	p.M450I	HEPH_ENST00000336279.5_Missense_Mutation_p.M129I|HEPH_ENST00000343002.2_Missense_Mutation_p.M396I|HEPH_ENST00000374727.3_Missense_Mutation_p.M399I|HEPH_ENST00000419594.1_Missense_Mutation_p.M399I|HEPH_ENST00000441993.2_Missense_Mutation_p.M399I			Q9BQS7	HEPH_HUMAN	hephaestin	396	Plastocyanin-like 3.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity	p.M396I(2)		endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|lung(56)|ovary(5)|prostate(1)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	89						ATGGCCCGATGGGGCATGATG	0.507000													14	36					0	0	0.00074312	0	0
VSTM1	284415	broad.mit.edu	37	19	54561647	54561647	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:54561647C>T	ENST00000338372.2	-	3	443	c.268G>A	c.(268-270)Gat>Aat	p.D90N	VSTM1_ENST00000376626.1_Missense_Mutation_p.D90N|VSTM1_ENST00000366170.2_Intron|VSTM1_ENST00000425006.2_Missense_Mutation_p.D90N	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	90	Ig-like V-type.					integral to membrane				breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		CTCCCAGCATCCTTAGGCTTC	0.532000													21	92					0	0	0.00152264	0	0
CD163L1	283316	broad.mit.edu	37	12	7531810	7531810	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:7531810C>T	ENST00000313599.3	-	9	2192	c.2135G>A	c.(2134-2136)gGa>gAa	p.G712E	CD163L1_ENST00000396630.1_Missense_Mutation_p.G712E|CD163L1_ENST00000416109.2_Missense_Mutation_p.G722E|CD163L1_ENST00000544331.1_Intron			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	712	SRCR 7.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						ACACAGAATTCCCACGGCACC	0.502000													27	49					0	0	0.00106085	0	0
OR5B3	441608	broad.mit.edu	37	11	58170745	58170745	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:58170745C>T	ENST00000309403.2	-	1	137	c.138G>A	c.(136-138)ttG>ttA	p.L46L		NM_001005469.1	NP_001005469.1	Q8NH48	OR5B3_HUMAN	olfactory receptor, family 5, subfamily B, member 3	46					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(6)|upper_aerodigestive_tract(1)	34	Esophageal squamous(5;0.0027)	Breast(21;0.0778)				CCCAGAATATCAATACAATAA	0.418000													23	29					0	0	0.000720815	0	0
ABCC1	4363	broad.mit.edu	37	16	16215894	16215894	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:16215894C>T	ENST00000399408.2	+	25	3658	c.3483C>T	c.(3481-3483)gtC>gtT	p.V1161V	ABCC1_ENST00000349029.5_Silent_p.V1036V|ABCC1_ENST00000351154.5_Silent_p.V1092V|ABCC1_ENST00000399410.3_Silent_p.V1151V|ABCC1_ENST00000345148.5_Silent_p.V1151V|ABCC1_ENST00000346370.5_Silent_p.V1095V			P33527	MRP1_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	1151	ABC transmembrane type-1 2.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process|response to drug	Golgi apparatus|integral to plasma membrane|membrane fraction|nucleus	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|endometrium(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(5)|prostate(1)|skin(3)	56					Daunorubicin(DB00694)|Glibenclamide(DB01016)|Probenecid(DB01032)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GCTCCCCGGTCTATTCCCATT	0.597000													13	41					0	0	0.00136819	0	0
KRT6A	3853	broad.mit.edu	37	12	52881529	52881529	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:52881529G>A	ENST00000330722.6	-	9	1738	c.1670C>T	c.(1669-1671)tCc>tTc	p.S557F		NM_005554.3	NP_005545.1	P02538	K2C6A_HUMAN	keratin 6A	557	Tail.				cell differentiation|ectoderm development|positive regulation of cell proliferation	keratin filament	protein binding|structural constituent of cytoskeleton			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|liver(1)|lung(14)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	39				BRCA - Breast invasive adenocarcinoma(357;0.189)		CTTCCTGCTGGAGGAGGAGGT	0.602000													22	56					0	0	0.00127121	0	0
DLG1	1739	broad.mit.edu	37	3	196792579	196792579	+	Splice_Site	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:196792579G>A	ENST00000346964.2	-	22	2488	c.2299_splice	c.e22+1	p.H767_splice	DLG1_ENST00000452595.1_Splice_Site_p.H629_splice|DLG1_ENST00000314062.3_Splice_Site_p.H694_splice|DLG1_ENST00000450955.1_Splice_Site_p.H734_splice|DLG1_ENST00000448528.2_Splice_Site_p.H745_splice|DLG1_ENST00000357674.4_Splice_Site_p.H734_splice|DLG1_ENST00000443183.1_Splice_Site_p.H641_splice|DLG1_ENST00000422288.1_Splice_Site_p.H694_splice|DLG1_ENST00000392382.2_Splice_Site_p.H712_splice|DLG1_ENST00000419354.1_Splice_Site_p.H745_splice	NM_004087.2	NP_004078.2	Q12959	DLG1_HUMAN	discs, large homolog 1 (Drosophila)	745	Guanylate kinase-like.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|liver(1)|lung(9)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	26	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		GTTTACTTACGAGGAACACAG	0.328000													18	32					0	0	0.00121646	0	0
MET	4233	broad.mit.edu	37	7	116409818	116409818	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:116409818G>A	ENST00000397752.3	+	12	2903	c.2703G>A	c.(2701-2703)ctG>ctA	p.L901L	MET_ENST00000318493.6_Silent_p.L919L	NM_000245.2|NM_001127500.1	NP_000236.2|NP_001120972.1	P08581	MET_HUMAN	met proto-oncogene	901					axon guidance|cell proliferation	basal plasma membrane|integral to plasma membrane	ATP binding|hepatocyte growth factor receptor activity|protein binding			NS(10)|breast(4)|central_nervous_system(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(5)|kidney(25)|large_intestine(8)|liver(3)|lung(70)|ovary(10)|pleura(2)|prostate(4)|skin(5)|stomach(6)|testis(1)|thyroid(4)|upper_aerodigestive_tract(64)|urinary_tract(3)	233	all_cancers(3;1.25e-07)|all_epithelial(6;4.07e-08)|Lung NSC(10;0.00108)|all_lung(10;0.00125)	Ovarian(593;0.133)	GBM - Glioblastoma multiforme(2;2.31e-07)|all cancers(2;0.000419)|STAD - Stomach adenocarcinoma(10;0.000512)			ATGACCTGCTGAAATTGAACA	0.383000			Mis		"""papillary renal, head-neck squamous cell """	papillary renal			Hereditary Papillary Renal Carcinoma (type 1)				34	56					0	0	0.000953801	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144852490	144852490	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:144852490G>A	ENST00000369359.4	-	47	7455	c.7417C>T	c.(7417-7419)Cta>Tta	p.L2473L	PDE4DIP_ENST00000369354.3_Silent_p.L2337L|PDE4DIP_ENST00000369356.4_Intron|PDE4DIP_ENST00000530740.1_Silent_p.L2422L|PDE4DIP_ENST00000313382.9_Silent_p.L2231L|PDE4DIP_ENST00000524974.1_5'UTR			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	2337					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		AGAGCCCTTAGGGATTTCACC	0.507000			T	PDGFRB	MPD								9	52					0	0	0.000673444	0	0
TMEM132B	114795	broad.mit.edu	37	12	126128723	126128723	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:126128723C>T	ENST00000299308.3	+	6	1532	c.1524C>T	c.(1522-1524)ttC>ttT	p.F508F	TMEM132B_ENST00000535886.1_Silent_p.F20F	NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	508						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CCTCCCAGTTCGAGGTCACTG	0.527000													26	42					0	0	0.00127121	0	0
TMPRSS13	84000	broad.mit.edu	37	11	117779432	117779432	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:117779432C>T	ENST00000528626.1	-	8	1145	c.1072G>A	c.(1072-1074)Gag>Aag	p.E358K	TMPRSS13_ENST00000526090.1_Missense_Mutation_p.E393K|TMPRSS13_ENST00000445164.2_Missense_Mutation_p.E393K|TMPRSS13_ENST00000430170.2_Missense_Mutation_p.E393K|TMPRSS13_ENST00000524993.1_Missense_Mutation_p.E393K	NM_001206789.1	NP_001193718.1	Q9BYE2	TMPSD_HUMAN	transmembrane protease, serine 13	388	Peptidase S1.				proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			endometrium(1)|kidney(3)|large_intestine(6)|lung(7)|pancreas(1)|prostate(1)|urinary_tract(1)	20	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.00106)		GAGGCTGCCTCAGGCAACTGG	0.597000													4	18					0	0	0.00198382	0	0
HECW1	23072	broad.mit.edu	37	7	43484587	43484587	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:43484587G>A	ENST00000395891.1	+	11	2421	c.1816G>A	c.(1816-1818)Gtg>Atg	p.V606M	HECW1_ENST00000453890.1_Missense_Mutation_p.V606M	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	606					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						GGTGGACACGGTGGCCGCTGA	0.711000													9	14					0	0	0.000442599	0	0
OR4E2	26686	broad.mit.edu	37	14	22134212	22134212	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr14:22134212G>A	ENST00000408935.1	+	1	916	c.916G>A	c.(916-918)Gtt>Att	p.V306I		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		GCAGAGACAAGTTTTTTTCAC	0.408000													5	8					0	0	0.000602214	0	0
PML	5371	broad.mit.edu	37	15	74337233	74337233	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:74337233G>A	ENST00000565898.1	+	8	2473	c.2389G>A	c.(2389-2391)Gct>Act	p.A797T	PML_ENST00000268058.3_Missense_Mutation_p.A845T			P29590	PML_HUMAN	promyelocytic leukemia	845					cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction resulting in induction of apoptosis|endoplasmic reticulum calcium ion homeostasis|induction of apoptosis|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|maintenance of protein location in nucleus|negative regulation of angiogenesis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of mitotic cell cycle|negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|negative regulation of telomerase activity|negative regulation of telomere maintenance via telomerase|negative regulation of transcription, DNA-dependent|negative regulation of translation in response to oxidative stress|PML body organization|positive regulation of defense response to virus by host|positive regulation of histone deacetylation|protein complex assembly|protein stabilization|protein targeting|regulation of calcium ion transport into cytosol|regulation of protein phosphorylation|response to hypoxia|response to virus|transcription, DNA-dependent	cytoplasm|cytosol|early endosome membrane|extrinsic to endoplasmic reticulum membrane|insoluble fraction|nuclear matrix|nuclear membrane|nucleolus|nucleus|PML body	cobalt ion binding|DNA binding|protein binding|protein heterodimerization activity|protein homodimerization activity|SUMO binding|transcription coactivator activity|ubiquitin protein ligase binding|zinc ion binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(8)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	31						CAACCTGCAGGCTCTGGGCAC	0.652000			T	"""RARA, PAX5"""	"""APL, ALL"""								29	55					0	0	0.001512	0	0
TAT	6898	broad.mit.edu	37	16	71610089	71610089	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:71610089G>A	ENST00000355962.4	-	2	363	c.230C>T	c.(229-231)tCc>tTc	p.S77F	RP11-432I5.1_ENST00000561529.1_RNA	NM_000353.2	NP_000344.1	P17735	ATTY_HUMAN	tyrosine aminotransferase	77					2-oxoglutarate metabolic process|glutamate metabolic process|L-phenylalanine catabolic process|tyrosine catabolic process	cytosol	1-aminocyclopropane-1-carboxylate synthase activity|L-tyrosine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(3)	29		Ovarian(137;0.125)		Kidney(780;0.0157)	L-Glutamic Acid(DB00142)|L-Phenylalanine(DB00120)|L-Tyrosine(DB00135)|Pyridoxal Phosphate(DB00114)	CTCACCAATGGACAGGGAAAT	0.502000													7	16					0	0	0.00198382	0	0
TNFAIP1	7126	broad.mit.edu	37	17	26669304	26669304	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:26669304G>A	ENST00000226225.2	+	6	817	c.550G>A	c.(550-552)Gag>Aag	p.E184K	TNFAIP1_ENST00000544907.2_Missense_Mutation_p.E80K|TNFAIP1_ENST00000583213.1_3'UTR	NM_021137.4	NP_066960.1	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1 (endothelial)	184					apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity	p.E184K(1)		endometrium(3)|kidney(1)|large_intestine(4)|lung(3)|prostate(1)	12	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		GAAAAACATCGAGCTGTTTGA	0.542000													11	19					0	0	0.00244969	0	0
TLL1	7092	broad.mit.edu	37	4	166996071	166996071	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:166996071G>A	ENST00000061240.2	+	17	2877	c.2230G>A	c.(2230-2232)Gaa>Aaa	p.E744K	TLL1_ENST00000507499.1_Missense_Mutation_p.E767K	NM_012464.4	NP_036596.3	O43897	TLL1_HUMAN	tolloid-like 1	744	EGF-like 2; calcium-binding (Potential).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(21)|lung(26)|ovary(2)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		ATGTCAGCACGAATGTGTCAA	0.393000													23	65					0	0	0.00229938	0	0
ATP4A	495	broad.mit.edu	37	19	36046380	36046380	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:36046380G>A	ENST00000262623.3	-	14	2147	c.2119C>T	c.(2119-2121)Cag>Tag	p.Q707*		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	707					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	AGCTTCTGCTGGGGGCTGGTG	0.662000													13	20					0	0	0.00136819	0	0
ABCD3	5825	broad.mit.edu	37	1	94944087	94944087	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:94944087G>A	ENST00000315713.5	+	9	692	c.692G>A	c.(691-693)gGa>gAa	p.G231E	ABCD3_ENST00000536817.1_Intron|ABCD3_ENST00000370214.4_Intron|ABCD3_ENST00000454898.2_Intron|ABCD3_ENST00000394233.2_Intron	NM_001122674.1	NP_001116146.1	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D (ALD), member 3	0	ABC transmembrane type-1.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(2)|lung(10)|ovary(1)|pancreas(1)|skin(2)	26		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		TAGGTACTTGGAAAAATTTTG	0.363000													6	14					0	0	0.000157383	0	0
NRXN3	9369	broad.mit.edu	37	14	79432748	79432748	+	Splice_Site	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr14:79432748G>A	ENST00000554719.1	+	9	2148	c.1658_splice	c.e9+1	p.G553_splice	NRXN3_ENST00000335750.5_Splice_Site_p.G553_splice	NM_004796.4	NP_004787.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	146					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GCTTGTCAAGGGGTAAGTAGA	0.418000													28	48					0	0	0.00283554	0	0
SLC22A8	9376	broad.mit.edu	37	11	62760988	62760988	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:62760988C>T	ENST00000336232.2	-	10	1572	c.1437G>A	c.(1435-1437)ggG>ggA	p.G479G	SLC22A8_ENST00000545207.1_Silent_p.G388G|SLC22A8_ENST00000535878.1_Silent_p.G356G|SLC22A8_ENST00000430500.2_Silent_p.G479G|SLC22A8_ENST00000311438.8_Silent_p.G479G	NM_001184732.1|NM_001184736.1|NM_004254.3	NP_001171661.1|NP_001171665.1|NP_004245.2	Q8TCC7	S22A8_HUMAN	solute carrier family 22 (organic anion transporter), member 8	479				YGI -> FTGS (in Ref. 1; AAD19357).	response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	28						GGGCGGTGATCCCGTAGATGA	0.582000													11	54					0	0	0.00185496	0	0
METTL2B	55798	broad.mit.edu	37	7	128119282	128119282	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:128119282G>A	ENST00000480046.1	+	2	193	c.78G>A	c.(76-78)aaG>aaA	p.K26K	METTL2B_ENST00000262432.8_Silent_p.K91K			Q6P1Q9	MTL2B_HUMAN	methyltransferase like 2B	91							methyltransferase activity			breast(1)|cervix(1)|large_intestine(2)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17						GGTTTTTCAAGGATAGACATT	0.348000													5	47					0	0	0.000157383	0	0
UGT2B4	7363	broad.mit.edu	37	4	70359494	70359494	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:70359494C>T	ENST00000305107.6	-	2	833	c.787G>A	c.(787-789)Gat>Aat	p.D263N	UGT2B4_ENST00000512583.1_Missense_Mutation_p.D263N|UGT2B4_ENST00000506580.1_5'UTR|UGT2B4_ENST00000381096.3_Missense_Mutation_p.D127N	NM_021139.2	NP_066962.2	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B4	263					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(29)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	47						AATTGAAAATCCCAGTAGTTT	0.418000													19	60					0	0	0.00074312	0	0
HTR4	3360	broad.mit.edu	37	5	147929700	147929700	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:147929700C>T	ENST00000360693.3	-	3	290	c.152_splice	c.e3+1	p.R51_splice	HTR4_ENST00000519495.1_5'UTR|HTR4_ENST00000377888.3_Splice_Site_p.R51_splice|HTR4_ENST00000520514.1_Splice_Site_p.R51_splice|HTR4_ENST00000521735.1_Splice_Site_p.R51_splice|HTR4_ENST00000314512.6_Splice_Site_p.R51_splice|HTR4_ENST00000521530.1_Splice_Site_p.R51_splice|HTR4_ENST00000354217.2_Splice_Site_p.R51_splice|HTR4_ENST00000517929.1_Splice_Site_p.R51_splice|HTR4_ENST00000362016.2_Splice_Site_p.R51_splice	NM_001040173.2	NP_001035263.1	Q13639	5HT4R_HUMAN	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled	51					G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cell proliferation	endosome|integral to plasma membrane|membrane fraction	serotonin receptor activity			endometrium(5)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Cisapride(DB00604)|Rizatriptan(DB00953)|Tegaserod(DB01079)|Zolmitriptan(DB00315)	TGCTGCTCACCTGAGCTGCCT	0.502000													12	12					0	0	0.00136819	0	0
L1TD1	54596	broad.mit.edu	37	1	62675455	62675455	+	Splice_Site	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:62675455G>A	ENST00000498273.1	+	4	1304	c.1008_splice	c.e4-1	p.D337_splice		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	337										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						TAACTTTCAGGATAAAACCCT	0.294000													15	50					0	0	0.00244969	0	0
IGF1R	3480	broad.mit.edu	37	15	99459195	99459195	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:99459195C>T	ENST00000268035.6	+	9	2442	c.1831C>T	c.(1831-1833)Cct>Tct	p.P611S	IGF1R_ENST00000558762.1_Missense_Mutation_p.P611S	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	611	Fibronectin type-III 2.				anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	CTCTCCAGTTCCTTCCATTCC	0.463000													52	134					0	0	0.000781405	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83361437	83361437	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:83361437A>G	ENST00000262752.2	-	15	1308	c.1301T>C	c.(1300-1302)gTt>gCt	p.V434A	RPS6KA6_ENST00000495332.1_5'UTR|RPS6KA6_ENST00000543399.1_Missense_Mutation_p.V434A	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	434	Protein kinase 2.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						GTAGGAGCCAACACCAATATC	0.348000													4	11					0	0	0.00024832	0	0
CR1	1378	broad.mit.edu	37	1	207751265	207751265	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:207751265G>A	ENST00000367049.4	+	29	4653	c.4653G>A	c.(4651-4653)ggG>ggA	p.G1551G	RP11-78B10.2_ENST00000597497.1_RNA|CR1_ENST00000367053.1_Silent_p.G1101G|CR1_ENST00000400960.2_Silent_p.G1101G|CR1_ENST00000367052.1_Silent_p.G1101G|RP11-78B10.2_ENST00000596003.1_RNA|CR1_ENST00000367051.1_Silent_p.G1101G	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1101	Sushi 24.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						GAAGCAGAGGGAGAAAGGTGT	0.517000													94	123					0	0	0.000781405	0	0
MX2	4600	broad.mit.edu	37	21	42778885	42778885	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr21:42778885C>T	ENST00000330714.3	+	13	2049	c.1865C>T	c.(1864-1866)tCc>tTc	p.S622F		NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)	622					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				TCGGTTTCCTCCTTTACTGAA	0.488000													16	32					0	0	0.00074312	0	0
PHACTR1	221692	broad.mit.edu	37	6	12718976	12718976	+	Translation_Start_Site	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:12718976G>A	ENST00000379350.1	+	0	129				PHACTR1_ENST00000379348.2_De_novo_Start_InFrame|PHACTR1_ENST00000332995.7_Intron			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1							cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			GAACATCAAGGATGGATTATC	0.368000													82	224					0	0	0.000781405	0	0
NPR2	4882	broad.mit.edu	37	9	35800423	35800423	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:35800423C>T	ENST00000342694.2	+	5	1416	c.1161C>T	c.(1159-1161)gaC>gaT	p.D387D		NM_003995.3	NP_003986.2	P20594	ANPRB_HUMAN	natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)	387					intracellular signal transduction|ossification|receptor guanylyl cyclase signaling pathway|regulation of blood pressure	integral to membrane|plasma membrane	GTP binding|guanylate cyclase activity|natriuretic peptide receptor activity|protein kinase activity|transmembrane receptor activity			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(2)|prostate(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	45	all_epithelial(49;0.161)		LUSC - Lung squamous cell carcinoma(32;0.00521)|Lung(28;0.00697)|STAD - Stomach adenocarcinoma(86;0.194)		Erythrityl Tetranitrate(DB01613)|Nesiritide(DB04899)	AGAACAATGACCGAGAGACTG	0.527000													14	89					0	0	0.000308642	0	0
VSIG1	340547	broad.mit.edu	37	X	107316583	107316583	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:107316583C>T	ENST00000415430.3	+	6	941	c.780C>T	c.(778-780)atC>atT	p.I260I	VSIG1_ENST00000217957.5_Silent_p.I224I	NM_001170553.1	NP_001164024.1	Q86XK7	VSIG1_HUMAN	V-set and immunoglobulin domain containing 1	224						integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	17						CCTGCGAAATCGATCTCACTT	0.413000													48	222					0	0	0.000781405	0	0
AKR1D1	6718	broad.mit.edu	37	7	137792257	137792257	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:137792257C>T	ENST00000242375.3	+	7	828	c.786C>T	c.(784-786)ttC>ttT	p.F262F	AKR1D1_ENST00000468877.2_3'UTR|AKR1D1_ENST00000432161.1_Silent_p.F262F|AKR1D1_ENST00000411726.2_Silent_p.F221F	NM_005989.3	NP_005980.1	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	262					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(14)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	23						TTTTGCGTTTCAACATCCAGC	0.378000													20	78					0	0	0.00229938	0	0
F8	2157	broad.mit.edu	37	X	154159922	154159922	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:154159922C>T	ENST00000360256.4	-	14	2343	c.2143G>A	c.(2143-2145)Gac>Aac	p.D715N		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	715	F5/8 type A 2.|Plastocyanin-like 4.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTCCGAAAGTCTGAGTTGTGG	0.423000													23	44					0	0	0.000586117	0	0
HNF1B	6928	broad.mit.edu	37	17	36091655	36091655	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:36091655G>A	ENST00000225893.4	-	4	1337	c.976C>T	c.(976-978)Ctg>Ttg	p.L326L	HNF1B_ENST00000561193.1_Silent_p.L300L|HNF1B_ENST00000560016.1_Silent_p.L326L|HNF1B_ENST00000427275.2_Silent_p.L300L	NM_000458.2|NM_001165923.1	NP_000449.1|NP_001159395.1	P35680	HNF1B_HUMAN	HNF1 homeobox B	326					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(6)|kidney(3)|large_intestine(2)|liver(1)|lung(3)|ovary(3)|prostate(1)|skin(2)	28		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			AGAGGGTTCAGGCTGTGAGTC	0.597000													171	320					0	0	0.000781405	0	0
GFPT1	2673	broad.mit.edu	37	2	69556550	69556550	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:69556550A>T	ENST00000357308.4	-	17	1782	c.1604T>A	c.(1603-1605)aTt>aAt	p.I535N	GFPT1_ENST00000361060.4_Missense_Mutation_p.I517N	NM_001244710.1	NP_001231639.1	Q06210	GFPT1_HUMAN	glutamine--fructose-6-phosphate transaminase 1	535					dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			endometrium(1)|large_intestine(3)|lung(5)|skin(3)	12						TACTTCCTTAATCAAATCTAA	0.323000													8	14					0	0	0.000157383	0	0
DPP6	1804	broad.mit.edu	37	7	154585800	154585800	+	Missense_Mutation	SNP	T	T	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:154585800T>C	ENST00000404039.1	+	11	1543	c.956T>C	c.(955-957)aTc>aCc	p.I319T	DPP6_ENST00000332007.3_Missense_Mutation_p.I321T|DPP6_ENST00000377770.3_Missense_Mutation_p.I383T|DPP6_ENST00000427557.1_Missense_Mutation_p.I276T	NM_001039350.1|NM_001936.3|NM_130797.2	NP_001034439.1|NP_001927.3|NP_570629.2	P42658	DPP6_HUMAN	dipeptidyl-peptidase 6	383					cell death|proteolysis	integral to membrane	dipeptidyl-peptidase activity|serine-type peptidase activity			NS(3)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(35)|pancreas(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	71	all_neural(206;0.181)	all_hematologic(28;0.0044)|all_lung(21;0.0176)|Lung NSC(21;0.0204)	OV - Ovarian serous cystadenocarcinoma(82;0.0562)			GAGTACTACATCACCATGGTG	0.652000													19	18					0	0	0.00152264	0	0
C6orf165	154313	broad.mit.edu	37	6	88119576	88119576	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:88119576G>A	ENST00000507897.1	+	2	102	c.19G>A	c.(19-21)Gaa>Aaa	p.E7K	C6ORF165_ENST00000369562.4_Missense_Mutation_p.E7K			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	7										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AACTCAGGCCGAAAGTGTTAT	0.333000													21	58					0	0	0.00229938	0	0
ZNF536	9745	broad.mit.edu	37	19	30936347	30936347	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:30936347G>A	ENST00000355537.3	+	2	2025	c.1878G>A	c.(1876-1878)atG>atA	p.M626I		NM_014717.1	NP_055532.1	O15090	ZN536_HUMAN	zinc finger protein 536	626					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			NS(3)|breast(6)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|lung(119)|ovary(7)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	182	Esophageal squamous(110;0.0834)					CTGGGAACATGAAGGAGAAGC	0.597000													23	107					0	0	0.000720815	0	0
KMT2C	58508	broad.mit.edu	37	7	151960106	151960106	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:151960106A>G	ENST00000355193.2	-	9	1512	c.1294T>C	c.(1294-1296)Tgc>Cgc	p.C432R	KMT2C_ENST00000262189.6_Missense_Mutation_p.C432R					lysine (K)-specific methyltransferase 2C																		CTTACTTTGCATTTCCAGCCA	0.338000													43	49					0	0	0.00170553	0	0
TONSL	4796	broad.mit.edu	37	8	145661975	145661975	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:145661975C>T	ENST00000409379.3	-	16	2009	c.1980G>A	c.(1978-1980)atG>atA	p.M660I	AC084125.4_ENST00000544423.1_RNA	NM_013432.4	NP_038460.4	Q96HA7	TONSL_HUMAN	tonsoku-like, DNA repair protein	660					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity			biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|lung(14)|ovary(3)|prostate(1)|skin(1)	26						GCAGCATCTCCATGGCCCTGG	0.672000													10	40					0	0	0.00185496	0	0
UBR1	197131	broad.mit.edu	37	15	43363063	43363063	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:43363063C>T	ENST00000290650.4	-	5	667	c.589G>A	c.(589-591)Gtg>Atg	p.V197M	UBR1_ENST00000382177.2_Missense_Mutation_p.V197M	NM_174916.2	NP_777576.1	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin 1	197					cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			NS(2)|endometrium(2)|kidney(7)|large_intestine(12)|lung(25)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	58		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		TATTTTATCACTGAAGGAAAT	0.378000													36	83					0	0	0.00058488	0	0
SALL1	6299	broad.mit.edu	37	16	51172871	51172871	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:51172871C>T	ENST00000440970.1	-	2	3402	c.2971G>A	c.(2971-2973)Gag>Aag	p.E991K	SALL1_ENST00000251020.4_Missense_Mutation_p.E1088K|SALL1_ENST00000566102.1_Intron|SALL1_ENST00000541611.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	1088					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CCGTTGACCTCTGTCTTGATG	0.562000													23	47					0	0	0.00278032	0	0
TNN	63923	broad.mit.edu	37	1	175097186	175097186	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:175097186G>A	ENST00000239462.4	+	14	3177	c.3064G>A	c.(3064-3066)Gaa>Aaa	p.E1022K		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	1022	Fibronectin type-III 9.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		GCTGGGACGGGAAGACCAGAG	0.552000													18	70					0	0	0.00074312	0	0
ADAM9	8754	broad.mit.edu	37	8	38865485	38865485	+	Missense_Mutation	SNP	A	A	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:38865485A>T	ENST00000487273.2	+	2	256	c.178A>T	c.(178-180)Agg>Tgg	p.R60W	ADAM9_ENST00000481513.1_Missense_Mutation_p.R60W|ADAM9_ENST00000466936.1_Missense_Mutation_p.R60W	NM_003816.2	NP_003807.1	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9	60				Missing (in Ref. 2; no nucleotide entry).	activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			AGAAGCCCCTAGGCCCTATTC	0.328000													14	45					0	0	0.00244969	0	0
NRAP	4892	broad.mit.edu	37	10	115365969	115365969	+	Silent	SNP	G	G	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:115365969G>T	ENST00000369358.4	-	33	4043	c.3799C>A	c.(3799-3801)Cga>Aga	p.R1267R	NRAP_ENST00000369360.3_Silent_p.R1232R|NRAP_ENST00000359988.3_Silent_p.R1259R|NRAP_ENST00000360478.3_Silent_p.R1224R			Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein	1259						fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(18)|lung(39)|ovary(6)|prostate(3)|skin(1)|stomach(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		GTTTTTGCTCGGATGAACTCG	0.433000													6	54					0.00198382	0.00948867	0.00198382	1	0
VAMP7	6845	broad.mit.edu	37	X	155127812	155127812	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:155127812G>A	ENST00000286448.6	+	4	406	c.241G>A	c.(241-243)Gag>Aag	p.E81K	VAMP7_ENST00000262640.6_Missense_Mutation_p.E81K|VAMP7_ENST00000479687.1_3'UTR|VAMP7_ENST00000460621.1_Missense_Mutation_p.E40K	NM_001145149.2|NM_005638.5	NP_001138621.1|NP_005629.1	P51809	VAMP7_HUMAN	vesicle-associated membrane protein 7	81	Longin.				calcium ion-dependent exocytosis|endosome to lysosome transport|eosinophil degranulation|ER to Golgi vesicle-mediated transport|neutrophil degranulation|phagocytosis, engulfment|post-Golgi vesicle-mediated transport|protein transport|vesicle fusion	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|late endosome membrane|lysosomal membrane|phagocytic vesicle membrane|plasma membrane|SNARE complex|transport vesicle membrane	protein binding			large_intestine(1)|lung(8)	9	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TTTTCTGAATGAGATAAAGAA	0.398000													15	86					0	0	0.00074312	0	0
KCND3	3752	broad.mit.edu	37	1	112329723	112329723	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:112329723C>T	ENST00000369697.1	-	2	1181	c.1112G>A	c.(1111-1113)gGa>gAa	p.G371E	KCND3_ENST00000302127.4_Missense_Mutation_p.G371E|KCND3_ENST00000315987.2_Missense_Mutation_p.G371E			Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related subfamily, member 3	371						sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(16)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	49		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		CACCATGTCTCCGTATCTGAG	0.522000													16	51					0	0	0.00074312	0	0
BMPER	168667	broad.mit.edu	37	7	34094894	34094894	+	Missense_Mutation	SNP	A	A	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:34094894A>C	ENST00000297161.2	+	10	1280	c.906A>C	c.(904-906)aaA>aaC	p.K302N	BMPER_ENST00000426693.1_Missense_Mutation_p.K302N	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	302	VWFC 5.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						AAGTATGCAAATTTGGCAACA	0.493000													29	151					0	0	0.00209593	0	0
DEFB114	245928	broad.mit.edu	37	6	49928133	49928133	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:49928133G>A	ENST00000322066.3	-	2	81	c.82C>T	c.(82-84)Cgt>Tgt	p.R28C		NM_001037499.1	NP_001032588.1	Q30KQ6	DB114_HUMAN	defensin, beta 114	28					defense response to bacterium	extracellular region		p.R28C(1)		kidney(1)|large_intestine(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	8	Lung NSC(77;0.042)					TTGGTGCAACGATCAGCATTC	0.353000													15	30					0	0	0.000422831	0	0
ADAM7	8756	broad.mit.edu	37	8	24326320	24326320	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:24326320C>T	ENST00000175238.6	+	7	703	c.620C>T	c.(619-621)gCt>gTt	p.A207V	RP11-624C23.1_ENST00000523578.1_RNA|ADAM7_ENST00000380789.1_Missense_Mutation_p.A207V|RP11-624C23.1_ENST00000519689.1_RNA	NM_003817.3	NP_003808.2	Q9H2U9	ADAM7_HUMAN	ADAM metallopeptidase domain 7	207	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(5)|kidney(1)|large_intestine(17)|lung(24)|ovary(1)|skin(15)	64		Prostate(55;0.0181)		Colorectal(74;0.0199)|COAD - Colon adenocarcinoma(73;0.0754)|BRCA - Breast invasive adenocarcinoma(99;0.182)		TTCATTGTTGCTGATGATACT	0.318000													19	49					0	0	0.00188189	0	0
ITPR1	3708	broad.mit.edu	37	3	4847918	4847918	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:4847918G>A	ENST00000302640.8	+	54	7544	c.7194G>A	c.(7192-7194)ggG>ggA	p.G2398G	ITPR1_ENST00000423119.2_Silent_p.G2365G|ITPR1_ENST00000357086.4_Silent_p.G2365G|ITPR1_ENST00000354582.6_Silent_p.G2398G|ITPR1_ENST00000443694.2_Silent_p.G2398G|ITPR1_ENST00000456211.2_Silent_p.G2350G|ITPR1_ENST00000463980.1_3'UTR|ITPR1_ENST00000544951.1_Silent_p.G376G	NM_001168272.1	NP_001161744.1	Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	2413					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		GTGCCATGGGGCTCTTTGTCC	0.468000													15	74					0	0	0.000422831	0	0
CRP	1401	broad.mit.edu	37	1	159683618	159683618	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:159683618G>A	ENST00000255030.5	-	2	475	c.372C>T	c.(370-372)atC>atT	p.I124I	CRP_ENST00000368112.1_Intron|CRP_ENST00000343919.2_Intron|CRP_ENST00000368111.1_Intron|CRP_ENST00000368110.1_Intron|CRP_ENST00000437342.1_5'UTR	NM_000567.2	NP_000558.2	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related	124	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			breast(1)|endometrium(3)|kidney(1)|lung(15)|ovary(1)|skin(1)	22	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	AGAACTCCACGATCCCTGAGG	0.522000													117	113					0	0	0.000781405	0	0
TRHDE	29953	broad.mit.edu	37	12	72863634	72863634	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:72863634C>T	ENST00000261180.4	+	4	1373	c.1277C>T	c.(1276-1278)tCa>tTa	p.S426L		NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	426					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						CCCAGTGTTTCATCTATTTCT	0.393000													12	46					0	0	0.00185496	0	0
OR2G6	391211	broad.mit.edu	37	1	248685082	248685082	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:248685082C>T	ENST00000343414.4	+	1	167	c.135C>T	c.(133-135)ctC>ctT	p.L45L		NM_001013355.1	NP_001013373.1	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G, member 6	45					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|cervix(1)|endometrium(2)|large_intestine(7)|lung(40)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACACTGCCCTCATACTAGTAT	0.478000													40	49					0	0	0.000953801	0	0
SLC16A9	220963	broad.mit.edu	37	10	61443926	61443926	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:61443926C>T	ENST00000395348.3	-	2	760	c.124G>A	c.(124-126)Gat>Aat	p.D42N	SLC16A9_ENST00000490066.1_5'UTR|SLC16A9_ENST00000395347.1_Missense_Mutation_p.D42N	NM_194298.2	NP_919274.1	Q7RTY1	MOT9_HUMAN	solute carrier family 16, member 9	42					urate metabolic process	integral to membrane|plasma membrane	symporter activity			kidney(3)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	23						CCAAAGGCATCCAGCCATTCT	0.478000													31	60					0	0	0.000814825	0	0
TAF7L	54457	broad.mit.edu	37	X	100532599	100532599	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:100532599G>A	ENST00000372907.3	-	9	955	c.944C>T	c.(943-945)tCg>tTg	p.S315L	TAF7L_ENST00000356784.1_Missense_Mutation_p.S229L|TAF7L_ENST00000324762.6_Missense_Mutation_p.S229L|TAF7L_ENST00000372905.2_Missense_Mutation_p.S229L	NM_024885.3	NP_079161.3	Q5H9L4	TAF7L_HUMAN	TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa	315					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|spermatogenesis|transcription initiation from RNA polymerase II promoter	cytoplasm|transcription factor TFIID complex	binding			NS(1)|breast(4)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	29						AGTACCTGACGAGGTATGACC	0.433000													32	191					0	0	0.000692331	0	0
CDC37L1	55664	broad.mit.edu	37	9	4697137	4697137	+	Missense_Mutation	SNP	G	G	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:4697137G>C	ENST00000381854.3	+	4	752	c.550G>C	c.(550-552)Gac>Cac	p.D184H	CDC37L1_ENST00000381858.1_Missense_Mutation_p.D184H	NM_017913.2	NP_060383.2	Q7L3B6	CD37L_HUMAN	cell division cycle 37-like 1	184	Self-association and interaction with Hsp90.					cytoplasm				breast(1)|kidney(1)|lung(2)	4	all_hematologic(13;0.137)	Breast(48;0.238)		GBM - Glioblastoma multiforme(50;0.0318)		ATTTTTGTCTGACCATCCATA	0.348000													10	55					0	0	0.000978159	0	0
PNPLA8	50640	broad.mit.edu	37	7	108154961	108154961	+	Silent	SNP	T	T	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:108154961T>C	ENST00000426128.2	-	2	1100	c.975A>G	c.(973-975)gaA>gaG	p.E325E	PNPLA8_ENST00000422087.1_Silent_p.E325E|PNPLA8_ENST00000483879.1_Intron|PNPLA8_ENST00000453144.1_Silent_p.E225E|PNPLA8_ENST00000436062.1_Silent_p.E325E|PNPLA8_ENST00000257694.8_Silent_p.E325E|PNPLA8_ENST00000388728.5_Silent_p.E325E	NM_001256009.1	NP_001242938.1	Q9NP80	PLPL8_HUMAN	patatin-like phospholipase domain containing 8	325					fatty acid metabolic process|lipid catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|membrane fraction|perinuclear region of cytoplasm|peroxisomal membrane	ATP binding|calcium-independent phospholipase A2 activity|lysophospholipase activity			breast(5)|endometrium(1)|kidney(3)|large_intestine(5)|lung(12)|upper_aerodigestive_tract(3)	29						TAGCAGGCTCTTCCTGTTCTT	0.438000													33	136					0	0	0.000692331	0	0
ADAM2	2515	broad.mit.edu	37	8	39624428	39624428	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:39624428C>T	ENST00000265708.4	-	14	1549	c.1446G>A	c.(1444-1446)tgG>tgA	p.W482*	ADAM2_ENST00000521880.1_Nonsense_Mutation_p.W482*|ADAM2_ENST00000347580.4_Nonsense_Mutation_p.W463*|ADAM2_ENST00000379853.2_Nonsense_Mutation_p.W356*	NM_001464.3	NP_001455.3	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2	482	Cys-rich.				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(29)|ovary(3)|prostate(1)|skin(5)|urinary_tract(1)	53		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		CTATACAGATCCATTGATTCA	0.388000													32	26					0	0	0.00283554	0	0
MUC16	94025	broad.mit.edu	37	19	9090789	9090789	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:9090789C>T	ENST00000397910.4	-	1	1229	c.1026G>A	c.(1024-1026)agG>agA	p.R342R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	342	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGCTTCTGACCCTTTCGGCAC	0.512000													4	33					0	0	0.00024832	0	0
CDHR2	54825	broad.mit.edu	37	5	176002198	176002198	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:176002198G>A	ENST00000510636.1	+	8	883	c.609G>A	c.(607-609)gaG>gaA	p.E203E	CDHR2_ENST00000261944.5_Silent_p.E203E|CDHR2_ENST00000506348.1_Silent_p.E203E	NM_001171976.1	NP_001165447.1	Q9BYE9	CDHR2_HUMAN	cadherin-related family member 2	203	Cadherin 2.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(8)|liver(1)|lung(23)|ovary(3)|prostate(5)|skin(4)|urinary_tract(1)	56						ACCAGCTGGAGCTGAAGGCCT	0.637000													39	42					0	0	0.0025221	0	0
OR2T33	391195	broad.mit.edu	37	1	248436915	248436915	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:248436915C>T	ENST00000318021.2	-	1	223	c.202G>A	c.(202-204)Gac>Aac	p.D68N		NM_001004695.1	NP_001004695.1	Q8NG76	O2T33_HUMAN	olfactory receptor, family 2, subfamily T, member 33	68					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|breast(1)|endometrium(6)|kidney(1)|large_intestine(10)|lung(41)|ovary(1)|prostate(1)|skin(4)	67	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AGCATCATGTCCATGAGGGAA	0.552000													49	138					0	0	0.000781405	0	0
SLC4A10	57282	broad.mit.edu	37	2	162660961	162660961	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:162660961C>T	ENST00000375514.5	+	4	453	c.166C>T	c.(166-168)Cat>Tat	p.H56Y	SLC4A10_ENST00000415876.2_Missense_Mutation_p.H45Y|SLC4A10_ENST00000421911.1_Missense_Mutation_p.H45Y|SLC4A10_ENST00000535165.1_Missense_Mutation_p.H45Y|SLC4A10_ENST00000493021.1_3'UTR|SLC4A10_ENST00000446997.1_Missense_Mutation_p.H45Y|SLC4A10_ENST00000272716.5_Missense_Mutation_p.H45Y	NM_001178016.1	NP_001171487.1	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate transporter, member 10	45					bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(35)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TTATGAAGGTCATCGAACACT	0.388000													9	23					0	0	0.000978159	0	0
PTPRB	5787	broad.mit.edu	37	12	71029686	71029686	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:71029686G>A	ENST00000334414.6	-	2	260	c.216C>T	c.(214-216)tcC>tcT	p.S72S	PTPRB_ENST00000538174.2_5'UTR|PTPRB_ENST00000550358.1_Silent_p.S72S|PTPRB_ENST00000551525.1_Silent_p.S71S	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	0	Fibronectin type-III 1.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			GGGAAGAGTTGGAGATGGCCA	0.562000													10	16					0	0	0.000978159	0	0
SPEF2	79925	broad.mit.edu	37	5	35727804	35727804	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:35727804G>A	ENST00000440995.2	+	21	2927	c.2927G>A	c.(2926-2928)gGa>gAa	p.G976E	SPEF2_ENST00000356031.3_Missense_Mutation_p.G981E|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	981					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TCATCAGGAGGAAAAGTACCA	0.388000													17	35					0	0	0.000422831	0	0
DDOST	1650	broad.mit.edu	37	1	20980210	20980210	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:20980210C>T	ENST00000375048.3	-	8	1008	c.903G>A	c.(901-903)aaG>aaA	p.K301K	DDOST_ENST00000602624.2_Silent_p.K284K|DDOST_ENST00000415136.2_Silent_p.K264K	NM_005216.4	NP_005207.2	P39656	OST48_HUMAN	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)	301					innate immune response|post-translational protein modification|response to cytokine stimulus|T cell activation	integral to membrane|microsome|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)|skin(1)	13		all_lung(284;2.98e-05)|Lung NSC(340;3.25e-05)|Colorectal(325;3.46e-05)|Renal(390;0.000147)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.17e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000141)|Kidney(64;0.000177)|GBM - Glioblastoma multiforme(114;0.00046)|KIRC - Kidney renal clear cell carcinoma(64;0.00262)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		CACCCTCCTCCTTGAACACCC	0.597000													11	22					0	0	0.000673444	0	0
ELL2	22936	broad.mit.edu	37	5	95226829	95226829	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:95226829G>A	ENST00000237853.4	-	10	2088	c.1739C>T	c.(1738-1740)tCt>tTt	p.S580F	ELL2_ENST00000431061.2_Missense_Mutation_p.S330F	NM_012081.5	NP_036213.2	O00472	ELL2_HUMAN	elongation factor, RNA polymerase II, 2	580					regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter	transcription elongation factor complex				breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(10)|pancreas(1)|prostate(2)	24		all_cancers(142;2.04e-06)|all_epithelial(76;3.1e-09)|all_lung(232;0.00309)|Lung NSC(167;0.00454)|Ovarian(225;0.0165)|Colorectal(57;0.0343)|Breast(839;0.198)		all cancers(79;2.16e-15)		TGAGCCTGGAGAAAGGCGCTT	0.428000													39	66					0	0	0.0025221	0	0
ZNF711	7552	broad.mit.edu	37	X	84525120	84525120	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:84525120G>A	ENST00000360700.4	+	9	2100	c.1214G>A	c.(1213-1215)aGg>aAg	p.R405K	ZNF711_ENST00000373165.3_Missense_Mutation_p.R359K|ZNF711_ENST00000395402.1_Missense_Mutation_p.R367K|ZNF711_ENST00000542798.1_Missense_Mutation_p.R201K|ZNF711_ENST00000276123.3_Missense_Mutation_p.R359K			Q9Y462	ZN711_HUMAN	zinc finger protein 711	359					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						GCCAAAAAGAGGAGAAGGGGA	0.348000													7	28					0	0	0.00198382	0	0
ABCB9	23457	broad.mit.edu	37	12	123424770	123424770	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:123424770C>T	ENST00000542678.1	-	9	4469	c.1631G>A	c.(1630-1632)gGg>gAg	p.G544E	ABCB9_ENST00000280560.8_Missense_Mutation_p.G544E|ABCB9_ENST00000442833.2_Missense_Mutation_p.G544E|ABCB9_ENST00000344275.7_Missense_Mutation_p.G544E|ABCB9_ENST00000392439.3_Missense_Mutation_p.G544E|ABCB9_ENST00000541983.1_5'UTR|ABCB9_ENST00000540285.1_Missense_Mutation_p.G481E|ABCB9_ENST00000442028.2_Missense_Mutation_p.G544E|ABCB9_ENST00000346530.5_Missense_Mutation_p.G501E			Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 9	544	ABC transporter.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(1)	18	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		GGAGCTCTTCCCACTGCCCGA	0.632000													14	116					0	0	0.00074312	0	0
MARCH11	441061	broad.mit.edu	37	5	16067614	16067614	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:16067614G>A	ENST00000332432.8	-	4	1374	c.1175C>T	c.(1174-1176)tCg>tTg	p.S392L		NM_001102562.1	NP_001096032.1	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	392						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)|urinary_tract(1)	20						AACCTCCCCCGAGCTGTTATC	0.463000													67	78					0	0	0.000781405	0	0
PLCZ1	89869	broad.mit.edu	37	12	18847966	18847966	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:18847966C>T	ENST00000447925.2	-	12	1602	c.1333G>A	c.(1333-1335)Ggg>Agg	p.G445R	PLCZ1_ENST00000539875.1_Missense_Mutation_p.G254R|PLCZ1_ENST00000534932.1_5'UTR|PLCZ1_ENST00000541695.1_Missense_Mutation_p.G310R|PLCZ1_ENST00000435379.1_Missense_Mutation_p.G252R|PLCZ1_ENST00000266505.7_Missense_Mutation_p.G447R|PLCZ1_ENST00000538330.1_Missense_Mutation_p.G229R	NM_033123.2	NP_149114.2	Q86YW0	PLCZ1_HUMAN	phospholipase C, zeta 1	447	PI-PLC Y-box.				intracellular signal transduction|lipid catabolic process|multicellular organismal development	nucleus|perinuclear region of cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	31	Acute lymphoblastic leukemia(4;0.000455)|all_hematologic(4;0.0241)					AAAAATTTCCCATTTTGCAGA	0.343000													12	44					0	0	0.00136819	0	0
KAT6A	7994	broad.mit.edu	37	8	41834788	41834788	+	Missense_Mutation	SNP	T	T	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:41834788T>A	ENST00000396930.3	-	8	1644	c.1101A>T	c.(1099-1101)aaA>aaT	p.K367N	KAT6A_ENST00000485568.1_Missense_Mutation_p.K367N|KAT6A_ENST00000265713.2_Missense_Mutation_p.K367N|KAT6A_ENST00000406337.1_Missense_Mutation_p.K367N	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	367	Interaction with RUNX1-1.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										AAAGAGTGATTTTTCGTTTCC	0.413000													20	61					0	0	0.00188189	0	0
EPHB6	2051	broad.mit.edu	37	7	142564278	142564278	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:142564278C>T	ENST00000392957.2	+	10	2289	c.1502C>T	c.(1501-1503)tCc>tTc	p.S501F	EPHB6_ENST00000411471.2_Missense_Mutation_p.S224F|EPHB6_ENST00000442129.1_Missense_Mutation_p.S501F	NM_004445.3	NP_004436.2	O15197	EPHB6_HUMAN	EPH receptor B6	501	Fibronectin type-III 2.					extracellular region|integral to plasma membrane	ATP binding|ephrin receptor activity			NS(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(9)|lung(46)|ovary(2)|pancreas(2)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	87	Melanoma(164;0.059)					AGCCGGGCATCCAACAGCATC	0.587000													30	25					0	0	0.00178596	0	0
RNF17	56163	broad.mit.edu	37	13	25433214	25433214	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr13:25433214G>A	ENST00000255324.5	+	26	3738	c.3686G>A	c.(3685-3687)tGg>tAg	p.W1229*	RNF17_ENST00000339524.3_Nonsense_Mutation_p.W281*|RNF17_ENST00000381921.1_Nonsense_Mutation_p.W1229*	NM_001184993.1|NM_031277.2	NP_001171922.1|NP_112567.2	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1229	Tudor 3.				multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(15)|ovary(1)|prostate(3)|skin(6)	36		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		CCTTATTTCTGGAAAAAAGGA	0.373000													10	25					0	0	0.000673444	0	0
DNAH7	56171	broad.mit.edu	37	2	196726449	196726449	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:196726449C>T	ENST00000312428.6	-	42	7828	c.7728G>A	c.(7726-7728)aaG>aaA	p.K2576K		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2576	Stalk (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						ACCTTCTTTTCTTTTCTAACA	0.284000													10	35					0	0	0.000673444	0	0
CCDC148	130940	broad.mit.edu	37	2	159077138	159077138	+	Missense_Mutation	SNP	T	T	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:159077138T>A	ENST00000283233.5	-	11	1652	c.1339A>T	c.(1339-1341)Atc>Ttc	p.I447F	CCDC148-AS1_ENST00000412781.2_RNA|CCDC148_ENST00000409187.1_Missense_Mutation_p.I456F	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	447										endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						TGTTCAGCGATTAATTTCTTC	0.328000													8	23					0	0	0.000673444	0	0
FAT3	120114	broad.mit.edu	37	11	92531999	92531999	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:92531999C>T	ENST00000298047.6	+	9	5837	c.5820C>T	c.(5818-5820)acC>acT	p.T1940T	FAT3_ENST00000409404.2_Silent_p.T1940T|FAT3_ENST00000525166.1_Silent_p.T1790T			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	1940	Cadherin 17.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GAGTACTTACCATAAAAAACA	0.423000										TCGA Ovarian(4;0.039)			145	271					0	0	0.000781405	0	0
ZFHX3	463	broad.mit.edu	37	16	72993437	72993437	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:72993437G>A	ENST00000268489.5	-	2	1280	c.608C>T	c.(607-609)tCc>tTc	p.S203F	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	203					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				TTTCCCGAAGGATGAGGCTAT	0.612000													31	97					0	0	0.00178596	0	0
HEMK1	51409	broad.mit.edu	37	3	50614591	50614591	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:50614591C>T	ENST00000232854.4	+	5	1075	c.523C>T	c.(523-525)Ctc>Ttc	p.L175F	HEMK1_ENST00000455834.1_Missense_Mutation_p.L175F|HEMK1_ENST00000434410.1_Missense_Mutation_p.L175F	NM_016173.3	NP_057257.1	Q9Y5R4	HEMK1_HUMAN	HemK methyltransferase family member 1	175					DNA methylation		DNA binding|N-methyltransferase activity|protein methyltransferase activity			lung(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000283)|KIRC - Kidney renal clear cell carcinoma(197;0.0179)|Kidney(197;0.0212)		AGCCATCTCCCTCAGCCTGCT	0.627000													10	50					0	0	0.000673444	0	0
ABCA13	154664	broad.mit.edu	37	7	48269475	48269475	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:48269475C>T	ENST00000435803.1	+	7	710	c.686C>T	c.(685-687)tCc>tTc	p.S229F		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	229					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						CAAACTTTTTCCCAGGTTTCT	0.408000													49	175					0	0	0.000781405	0	0
LTBP2	4053	broad.mit.edu	37	14	75052711	75052711	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr14:75052711C>T	ENST00000261978.4	-	3	1062	c.676G>A	c.(676-678)Gaa>Aaa	p.E226K	LTBP2_ENST00000556690.1_Missense_Mutation_p.E226K|LTBP2_ENST00000557425.1_Intron	NM_000428.2	NP_000419.1	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding protein 2	226					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(9)|liver(1)|lung(29)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GGGTCAAATTCCTCATCGGGA	0.682000													14	10					0	0	0.000422831	0	0
NWD1	284434	broad.mit.edu	37	19	16859961	16859961	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:16859961G>A	ENST00000524140.2	+	6	926	c.508G>A	c.(508-510)Gag>Aag	p.E170K	NWD1_ENST00000552788.1_Missense_Mutation_p.E170K|NWD1_ENST00000549814.1_Missense_Mutation_p.E170K|NWD1_ENST00000523826.1_5'UTR|NWD1_ENST00000339803.6_Missense_Mutation_p.E35K|NWD1_ENST00000379808.3_Missense_Mutation_p.E170K	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	170							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						CATTGAGTGGGAGATAGAGCG	0.542000													6	22					0	0	0.00198382	0	0
CDH17	1015	broad.mit.edu	37	8	95178002	95178002	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:95178002C>T	ENST00000027335.3	-	10	1393	c.1269G>A	c.(1267-1269)gaG>gaA	p.E423E	CDH17_ENST00000441892.2_Silent_p.E209E|CDH17_ENST00000450165.2_Silent_p.E423E	NM_004063.3	NP_004054.3	Q12864	CAD17_HUMAN	cadherin 17, LI cadherin (liver-intestine)	423	Cadherin 4.					integral to membrane	calcium ion binding			NS(1)|endometrium(5)|kidney(3)|large_intestine(10)|lung(18)|ovary(6)|prostate(3)|skin(4)|stomach(2)	52	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TGTCAGACACCTCTATCGTTA	0.398000													15	53					0	0	0.000566183	0	0
LTBP1	4052	broad.mit.edu	37	2	33500129	33500129	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:33500129G>A	ENST00000404816.2	+	17	3194	c.2841G>A	c.(2839-2841)atG>atA	p.M947I	LTBP1_ENST00000404525.1_Missense_Mutation_p.M568I|LTBP1_ENST00000402934.1_Missense_Mutation_p.M568I|LTBP1_ENST00000354476.3_Missense_Mutation_p.M948I|LTBP1_ENST00000418533.2_Missense_Mutation_p.M621I|LTBP1_ENST00000390003.4_Missense_Mutation_p.M622I|LTBP1_ENST00000407925.1_Missense_Mutation_p.M621I			Q14766	LTBP1_HUMAN	latent transforming growth factor beta binding protein 1	947	EGF-like 5; calcium-binding (Potential).				negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta	proteinaceous extracellular matrix	calcium ion binding|growth factor binding|transforming growth factor beta receptor activity			breast(2)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(13)|lung(60)|ovary(4)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(3)	108	all_hematologic(175;0.115)	Medulloblastoma(90;0.215)				CAGGATTTATGGCCAGTGAGG	0.463000													19	50					0	0	0.00229938	0	0
ATP2A3	489	broad.mit.edu	37	17	3854588	3854588	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:3854588G>A	ENST00000309890.7	-	5	570	c.420C>T	c.(418-420)atC>atT	p.I140I	ATP2A3_ENST00000397041.3_Silent_p.I140I|ATP2A3_ENST00000397039.1_5'UTR|ATP2A3_ENST00000397043.3_Silent_p.I140I|ATP2A3_ENST00000352011.3_Silent_p.I140I|ATP2A3_ENST00000397035.3_Silent_p.I140I|ATP2A3_ENST00000359983.3_Silent_p.I140I	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	140					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		CCCGGGCACGGATCCTCTGCA	0.517000													15	24					0	0	0.00074312	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42437807	42437807	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:42437807G>A	ENST00000397272.3	-	16	1843	c.1752C>T	c.(1750-1752)ttC>ttT	p.F584F	PLA2G4F_ENST00000382396.4_Silent_p.F582F	NM_213600.3	NP_998765.3	Q68DD2	PA24F_HUMAN	phospholipase A2, group IVF	582	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		ACCACTCCAGGAAGCTGAGGC	0.622000													35	86					0	0	0.00128727	0	0
FSCN3	29999	broad.mit.edu	37	7	127235455	127235455	+	Missense_Mutation	SNP	G	G	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:127235455G>C	ENST00000265825.5	+	2	458	c.239G>C	c.(238-240)gGc>gCc	p.G80A	FSCN3_ENST00000478328.1_3'UTR|FSCN3_ENST00000420086.2_5'UTR	NM_020369.2	NP_065102.1	Q9NQT6	FSCN3_HUMAN	fascin homolog 3, actin-bundling protein, testicular (Strongylocentrotus purpuratus)	80						actin cytoskeleton|cytoplasm	actin filament binding|protein binding, bridging			endometrium(2)|large_intestine(3)|liver(2)|lung(17)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	30						GAGTGTGATGGCACCGTGTGT	0.577000													19	71					0	0	0.00152264	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110431368	110431368	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:110431368G>A	ENST00000378402.5	+	22	2507	c.2403G>A	c.(2401-2403)acG>acA	p.T801T		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	801					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TCGTAAGAACGAAATACACTG	0.373000										HNSCC(38;0.096)			14	35					0	0	0.000566183	0	0
STON1	11037	broad.mit.edu	37	2	48808712	48808712	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:48808712G>A	ENST00000309835.3	+	1	950	c.940G>A	c.(940-942)Gga>Aga	p.G314R	STON1_ENST00000406226.1_Missense_Mutation_p.G314R|STON1-GTF2A1L_ENST00000405008.1_Missense_Mutation_p.G314R|STON1_ENST00000404752.1_Missense_Mutation_p.G314R|STON1-GTF2A1L_ENST00000402114.2_Missense_Mutation_p.G314R|STON1-GTF2A1L_ENST00000394751.3_Missense_Mutation_p.G314R|STON1-GTF2A1L_ENST00000394754.1_Missense_Mutation_p.G314R|STON1-GTF2A1L_ENST00000309827.2_Missense_Mutation_p.G314R					stonin 1											NS(1)|endometrium(1)|kidney(2)|large_intestine(9)|lung(19)|prostate(3)|skin(2)	37		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			TTATGAACAGGGATTAGAAAA	0.393000													36	79					0	0	0.000814825	0	0
MSH3	4437	broad.mit.edu	37	5	80057454	80057454	+	Missense_Mutation	SNP	T	T	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr5:80057454T>G	ENST00000265081.6	+	13	1933	c.1853T>G	c.(1852-1854)tTg>tGg	p.L618W		NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	618					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		CTACGTAAATTGCCCGACATA	0.393000								Mismatch excision repair (MMR)					11	28					0	0	0.00244969	0	0
RAB4B-EGLN2	100529264	broad.mit.edu	37	19	41289901	41289901	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:41289901C>T	ENST00000594136.1	+	5	456	c.351C>T	c.(349-351)atC>atT	p.I117I	RAB4B_ENST00000602069.1_3'UTR|RAB4B-EGLN2_ENST00000601949.1_Intron|RAB4B_ENST00000594800.1_Silent_p.I117I|RAB4B_ENST00000357052.2_Silent_p.I117I|MIA-RAB4B_ENST00000600729.1_3'UTR																							TCGTGGTCATCCTCTGTGGCA	0.627000													5	28					0	0	0.00116845	0	0
TRAK2	66008	broad.mit.edu	37	2	202251159	202251159	+	Missense_Mutation	SNP	C	C	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:202251159C>A	ENST00000332624.3	-	14	2173	c.1745G>T	c.(1744-1746)gGa>gTa	p.G582V		NM_015049.2	NP_055864.2	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	582				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	23						AAGGATGGTTCCCAAGTTTGG	0.443000													45	108					8.48111e-28	4.20755e-27	0.000781405	1	0
NAB1	4664	broad.mit.edu	37	2	191524549	191524549	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:191524549A>G	ENST00000337386.5	+	4	1108	c.647A>G	c.(646-648)aAt>aGt	p.N216S	NAB1_ENST00000409641.1_Missense_Mutation_p.N216S|NAB1_ENST00000409581.1_Missense_Mutation_p.N216S|NAB1_ENST00000357215.5_Missense_Mutation_p.N216S	NM_005966.3	NP_005957.2	Q13506	NAB1_HUMAN	NGFI-A binding protein 1 (EGR1 binding protein 1)	216					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				kidney(2)|large_intestine(2)|lung(1)|prostate(1)|skin(1)	7			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0405)|all cancers(119;0.109)			AGTGACTTGAATGAAGTGAAA	0.493000													8	33					0	0	0.000442599	0	0
AADACL3	126767	broad.mit.edu	37	1	12785271	12785271	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:12785271G>A	ENST00000332530.3	+	3	377	c.151G>A	c.(151-153)Gat>Aat	p.D51N	AADACL3_ENST00000359318.5_Missense_Mutation_p.D121N	NM_001103169.1	NP_001096639.1	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3	121							hydrolase activity			breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	15	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GAAGTCCCTGGATGCATATGG	0.512000													35	81					0	0	0.000814825	0	0
AMER3	205147	broad.mit.edu	37	2	131520521	131520521	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:131520521G>A	ENST00000423981.1	+	2	986	c.876G>A	c.(874-876)gtG>gtA	p.V292V	AMER3_ENST00000321420.4_Silent_p.V292V	NM_001105193.1|NM_001105194.1|NM_001105195.1|NM_152698.2	NP_001098663.1|NP_001098664.1|NP_001098665.1|NP_689911.2			APC membrane recruitment protein 3																		AGGGCAGTGTGGAGCAGCTGG	0.652000													9	45					0	0	0.000442599	0	0
NRROS	375387	broad.mit.edu	37	3	196381472	196381472	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:196381472A>G	ENST00000328557.4	+	2	265	c.62A>G	c.(61-63)aAc>aGc	p.N21S		NM_198565.1	NP_940967.1			negative regulator of reactive oxygen species																		GGCTGGAGGAACAGAAGCGGA	0.577000													18	49					0	0	0.000958276	0	0
GFPT1	2673	broad.mit.edu	37	2	69556548	69556548	+	Nonsense_Mutation	SNP	T	T	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:69556548T>A	ENST00000357308.4	-	17	1784	c.1606A>T	c.(1606-1608)Aag>Tag	p.K536*	GFPT1_ENST00000361060.4_Nonsense_Mutation_p.K518*	NM_001244710.1	NP_001231639.1	Q06210	GFPT1_HUMAN	glutamine--fructose-6-phosphate transaminase 1	536					dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			endometrium(1)|large_intestine(3)|lung(5)|skin(3)	12						AGTACTTCCTTAATCAAATCT	0.323000													8	15					0	0	0.000274275	0	0
DST	667	broad.mit.edu	37	6	56471353	56471353	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:56471353G>A	ENST00000370754.5	-	39	7973	c.7974C>T	c.(7972-7974)ttC>ttT	p.F2658F	DST_ENST00000421834.2_Intron|DST_ENST00000244364.6_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000370769.4_Silent_p.F2480F|DST_ENST00000361203.3_Silent_p.F2480F|DST_ENST00000312431.6_Silent_p.F2480F|DST_ENST00000446842.2_Silent_p.F2154F			Q03001	DYST_HUMAN	dystonin	2480					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			CATCCATAAGGAAATCCTGAA	0.388000													23	57					0	0	0.00229938	0	0
CLEC5A	23601	broad.mit.edu	37	7	141643748	141643748	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:141643748C>T	ENST00000546910.1	-	4	352	c.156G>A	c.(154-156)ggG>ggA	p.G52G	CLEC5A_ENST00000551012.2_Intron|CLEC5A_ENST00000438351.1_Intron|CLEC5A_ENST00000470595.1_Intron|CLEC5A_ENST00000439991.1_Intron	NM_013252.2	NP_037384.1	Q9NY25	CLC5A_HUMAN	C-type lectin domain family 5, member A	52					anti-apoptosis|cellular defense response|innate immune response|interspecies interaction between organisms|osteoblast development	cell surface|integral to plasma membrane	sugar binding|viral receptor activity			endometrium(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	10	Melanoma(164;0.0171)					GGGAACTGCTCCCAAAAATCT	0.438000													72	92					0	0	0.000781405	0	0
TONSL	4796	broad.mit.edu	37	8	145661974	145661974	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:145661974C>T	ENST00000409379.3	-	16	2010	c.1981G>A	c.(1981-1983)Gag>Aag	p.E661K	AC084125.4_ENST00000544423.1_RNA	NM_013432.4	NP_038460.4	Q96HA7	TONSL_HUMAN	tonsoku-like, DNA repair protein	661					cytoplasmic sequestering of transcription factor|double-strand break repair via homologous recombination|replication fork processing	cytoplasm|nuclear replication fork	histone binding|transcription corepressor activity			biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|lung(14)|ovary(3)|prostate(1)|skin(1)	26						AGCAGCATCTCCATGGCCCTG	0.677000													10	39					0	0	0.00136819	0	0
TMEM61	199964	broad.mit.edu	37	1	55452004	55452004	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:55452004G>A	ENST00000371268.3	+	2	524	c.250G>A	c.(250-252)Ggc>Agc	p.G84S	RP11-12C17.2_ENST00000436960.1_RNA	NM_182532.1	NP_872338.1	Q8N0U2	TMM61_HUMAN	transmembrane protein 61	84						integral to membrane				endometrium(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	4						GCTGCTCATTGGCCTGCTGTG	0.652000													41	105					0	0	0.00170553	0	0
ANK3	288	broad.mit.edu	37	10	61830452	61830452	+	Missense_Mutation	SNP	G	G	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:61830452G>T	ENST00000280772.1	-	37	10378	c.10187C>A	c.(10186-10188)tCc>tAc	p.S3396Y	ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3396					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGTGGCAATGGAACACTCTGT	0.468000													32	43					4.62619e-21	2.29121e-20	0.000814825	1	0
COL2A1	1280	broad.mit.edu	37	12	48376908	48376908	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:48376908C>T	ENST00000380518.3	-	32	2226	c.2062G>A	c.(2062-2064)Gaa>Aaa	p.E688K	COL2A1_ENST00000493991.1_5'UTR|COL2A1_ENST00000337299.6_Missense_Mutation_p.E619K	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	688	Triple-helical region.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	GCTCCAGCTTCACCGGGAACA	0.577000													4	7					0	0	0.00024832	0	0
MED13L	23389	broad.mit.edu	37	12	116434479	116434479	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:116434479G>T	ENST00000281928.3	-	16	3004	c.2798C>A	c.(2797-2799)tCa>tAa	p.S933*		NM_015335.4	NP_056150.1	Q71F56	MD13L_HUMAN	mediator complex subunit 13-like	933					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent					NS(2)|breast(1)|endometrium(9)|kidney(3)|large_intestine(18)|lung(34)|ovary(4)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	85	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.0407)		GTGCACATATGAAAAGTCCTG	0.418000													10	40					0.000673444	0.00327452	0.000673444	1	0
NPSR1	387129	broad.mit.edu	37	7	34698142	34698142	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:34698142G>A	ENST00000360581.1	+	1	246	c.118G>A	c.(118-120)Gaa>Aaa	p.E40K	NPSR1_ENST00000381539.3_Missense_Mutation_p.E40K|NPSR1_ENST00000531252.1_Missense_Mutation_p.E40K|NPSR1_ENST00000381542.1_Missense_Mutation_p.E40K|NPSR1_ENST00000359791.1_Missense_Mutation_p.E40K|AC005493.1_ENST00000399077.1_Intron|NPSR1_ENST00000465305.1_Missense_Mutation_p.E40K|NPSR1_ENST00000381553.3_Missense_Mutation_p.E40K|NPSR1-AS1_ENST00000419766.1_RNA	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	40						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	GGAAGGAAAGGAATGGGGTTC	0.478000													11	56					0	0	0.00136819	0	0
MAPK6	5597	broad.mit.edu	37	15	52356250	52356250	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:52356250G>T	ENST00000261845.5	+	6	2026	c.1219G>T	c.(1219-1221)Gaa>Taa	p.E407*	CTD-2184D3.5_ENST00000558607.1_RNA	NM_002748.3	NP_002739.1	Q16659	MK06_HUMAN	mitogen-activated protein kinase 6	407					cell cycle		ATP binding|MAP kinase activity			breast(3)|endometrium(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|skin(2)	20				all cancers(107;0.0028)		TGGAGATCGGGAAAAGTATCT	0.403000													12	40					9.05144e-12	4.44536e-11	0.00185496	1	0
NMUR1	10316	broad.mit.edu	37	2	232390033	232390033	+	Silent	SNP	G	G	A	rs149953749		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:232390033G>A	ENST00000305141.4	-	3	1135	c.1002C>T	c.(1000-1002)ttC>ttT	p.F334F		NM_006056.4	NP_006047.3	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	334					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(12)|pancreas(1)|skin(1)	24		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		GCACGTGCTGGAAGGCCAGGT	0.632000													24	46					0	0	0.000586117	0	0
POMT1	10585	broad.mit.edu	37	9	134382804	134382804	+	Silent	SNP	C	C	T	rs138064523	byFrequency	TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:134382804C>T	ENST00000423007.1	+	5	772	c.330C>T	c.(328-330)ctC>ctT	p.L110L	POMT1_ENST00000402686.3_Silent_p.L110L|POMT1_ENST00000404875.2_5'UTR|POMT1_ENST00000372228.3_Silent_p.L110L|POMT1_ENST00000419118.2_Intron|POMT1_ENST00000354713.4_Silent_p.L80L|POMT1_ENST00000341012.7_Silent_p.L56L|POMT1_ENST00000541219.1_Intron	NM_001136113.1	NP_001129585.1	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1	110					multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	31		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		TGCCAGCACTCGCGGGGGCCT	0.562000													33	60					0	0	0.00283554	0	0
PTPRT	11122	broad.mit.edu	37	20	41514563	41514563	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:41514563G>A	ENST00000373198.3	-	2	333	c.98C>T	c.(97-99)tCc>tTc	p.S33F	PTPRT_ENST00000373187.1_Missense_Mutation_p.S33F|PTPRT_ENST00000373190.1_Missense_Mutation_p.S33F|PTPRT_ENST00000373193.3_Missense_Mutation_p.S33F|PTPRT_ENST00000356100.2_Missense_Mutation_p.S33F|PTPRT_ENST00000485499.1_5'UTR|PTPRT_ENST00000373201.1_Missense_Mutation_p.S33F|PTPRT_ENST00000373184.1_Missense_Mutation_p.S33F	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	33	MAM.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CTCATCAAAGGAACAGCCACC	0.478000													27	47					0	0	0.00127121	0	0
BAIAP3	8938	broad.mit.edu	37	16	1395287	1395287	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr16:1395287C>T	ENST00000324385.5	+	22	2241	c.2083C>T	c.(2083-2085)Ccc>Tcc	p.P695S	BAIAP3_ENST00000562208.1_Missense_Mutation_p.P637S|BAIAP3_ENST00000421665.2_Missense_Mutation_p.P624S|BAIAP3_ENST00000426824.3_Missense_Mutation_p.P660S|BAIAP3_ENST00000397488.2_Missense_Mutation_p.P677S|BAIAP3_ENST00000568887.1_Missense_Mutation_p.P632S|BAIAP3_ENST00000397489.1_Missense_Mutation_p.P677S	NM_003933.4	NP_003924.2	O94812	BAIP3_HUMAN	BAI1-associated protein 3	695	MHD1.				G-protein coupled receptor protein signaling pathway|neurotransmitter secretion		protein C-terminus binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(25)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42		Hepatocellular(780;0.0893)				CATCCACGCCCCCTTCCTGCC	0.642000													19	52					0	0	0.000958276	0	0
CFTR	1080	broad.mit.edu	37	7	117254679	117254679	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:117254679G>A	ENST00000003084.6	+	21	3512	c.3380G>A	c.(3379-3381)gGa>gAa	p.G1127E	CFTR_ENST00000454343.1_Missense_Mutation_p.G1066E|AC000111.6_ENST00000456270.1_RNA	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	1127	ABC transmembrane type-1 2.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding	p.G1127A(1)		NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GAAGGAGAAGGAAGAGTTGGT	0.398000									Cystic Fibrosis				14	68					0	0	0.000308642	0	0
RP1L1	94137	broad.mit.edu	37	8	10467773	10467773	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:10467773C>T	ENST00000382483.3	-	4	4058	c.3835G>A	c.(3835-3837)Gac>Aac	p.D1279N		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1279					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		TCCTCACTGTCTCTTTCTGCT	0.517000													43	108					0	0	0.000781405	0	0
TP53	7157	broad.mit.edu	37	17	7577082	7577082	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:7577082C>T	ENST00000420246.2	-	8	988	c.856G>A	c.(856-858)Gaa>Aaa	p.E286K	TP53_ENST00000455263.2_Missense_Mutation_p.E286K|TP53_ENST00000445888.2_Missense_Mutation_p.E286K|TP53_ENST00000269305.4_Missense_Mutation_p.E286K|TP53_ENST00000413465.2_Intron|TP53_ENST00000359597.4_Missense_Mutation_p.E286K	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	286	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		E -> A (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> Q (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E286K(58)|p.E286*(22)|p.0?(8)|p.E286Q(5)|p.?(2)|p.E286fs*59(2)|p.E286fs*17(2)|p.R283fs*16(2)|p.R282_E287delRRTEEE(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.T284_G293del10(1)|p.E285_L289delEEENL(1)|p.R283fs*56(1)|p.E285fs*13(1)|p.G279fs*59(1)|p.R283fs*59(1)|p.V272_K292del21(1)|p.E285_N288delEEEN(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGATTCTCTTCCTCTGTGCGC	0.557000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			6	28					0	0	0.000157383	0	0
PLCB1	23236	broad.mit.edu	37	20	8717814	8717814	+	Missense_Mutation	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:8717814A>G	ENST00000378641.3	+	20	2658	c.2183A>G	c.(2182-2184)gAa>gGa	p.E728G	PLCB1_ENST00000378637.2_Missense_Mutation_p.E728G|PLCB1_ENST00000494924.1_3'UTR|PLCB1_ENST00000338037.6_Missense_Mutation_p.E728G	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	728	C2.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						CCTGTCTGGGAAGAAGAACCT	0.378000													16	55					0	0	0.000958276	0	0
SDE2	163859	broad.mit.edu	37	1	226176046	226176046	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:226176046C>A	ENST00000272091.7	-	6	703	c.685G>T	c.(685-687)Gag>Tag	p.E229*	SDE2_ENST00000366817.1_Nonsense_Mutation_p.E134*	NM_152608.3	NP_689821.3			SDE2 telomere maintenance homolog (S. pombe)																		TCTGAACTCTCAGAGTTGGAC	0.453000													6	131					0.00198382	0.00948867	0.00198382	1	0
MAGEA10	4109	broad.mit.edu	37	X	151303936	151303936	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:151303936G>A	ENST00000370323.4	-	4	473	c.157C>T	c.(157-159)Ccc>Tcc	p.P53S	RP11-1007I13.4_ENST00000509345.2_RNA|MAGEA10_ENST00000244096.3_Missense_Mutation_p.P53S	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	53										endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					gaggaggagggaaaagaggat	0.557000													12	47					0	0	0.000978159	0	0
TTN	7273	broad.mit.edu	37	2	179615354	179615354	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:179615354C>T	ENST00000360870.5	-	46	11995	c.11773G>A	c.(11773-11775)Gaa>Aaa	p.E3925K	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000589042.1_Intron|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342992.6_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9745							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGTTTTCTTCCTTCTGTTCG	0.338000													16	31					0	0	0.000308642	0	0
TTN	7273	broad.mit.edu	37	2	179584546	179584546	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:179584546G>A	ENST00000589042.1	-	82	23897	c.23673C>T	c.(23671-23673)atC>atT	p.I7891I	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Silent_p.I7574I|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Silent_p.I6647I	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7574	Ig-like 61.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCTTCTCTATGATTCTTGCTG	0.393000													9	24					0	0	0.000274275	0	0
RUVBL2	10856	broad.mit.edu	37	19	49507615	49507615	+	Missense_Mutation	SNP	G	G	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:49507615G>T	ENST00000413176.2	+	4	1218	c.70G>T	c.(70-72)Gcc>Tcc	p.A24S	RUVBL2_ENST00000601968.1_Missense_Mutation_p.A24S|RUVBL2_ENST00000595090.1_Missense_Mutation_p.A69S			Q9Y230	RUVB2_HUMAN	RuvB-like AAA ATPase 2	69					cellular response to UV|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|protein folding|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|membrane|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|ATP-dependent DNA helicase activity|damaged DNA binding|identical protein binding|unfolded protein binding			large_intestine(1)|upper_aerodigestive_tract(1)	2		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000449)|OV - Ovarian serous cystadenocarcinoma(262;0.000555)|GBM - Glioblastoma multiforme(486;0.00585)|Epithelial(262;0.047)		AGGGAAGATTGCCGGTCGGGC	0.662000													20	54					8.04996e-18	3.9668e-17	0.00188189	1	0
POM121L12	285877	broad.mit.edu	37	7	53103666	53103666	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:53103666C>T	ENST00000408890.4	+	1	318	c.302C>T	c.(301-303)gCc>gTc	p.A101V		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	101										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						AGGCGCCCTGCCCTTCCCGGG	0.726000													12	26					0	0	0.000978159	0	0
ASNS	440	broad.mit.edu	37	7	97488575	97488575	+	Missense_Mutation	SNP	C	C	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:97488575C>A	ENST00000175506.4	-	6	1151	c.623G>T	c.(622-624)cGg>cTg	p.R208L	ASNS_ENST00000437628.1_Missense_Mutation_p.R125L|ASNS_ENST00000394309.3_Missense_Mutation_p.R208L|ASNS_ENST00000444334.1_Missense_Mutation_p.R187L|ASNS_ENST00000422745.1_Missense_Mutation_p.R187L|ASNS_ENST00000394308.3_Missense_Mutation_p.R208L|ASNS_ENST00000455086.1_Missense_Mutation_p.R125L	NM_183356.3	NP_899199.2	P08243	ASNS_HUMAN	asparagine synthetase (glutamine-hydrolyzing)	208					cellular response to glucose starvation|glutamine metabolic process|negative regulation of apoptosis|positive regulation of mitotic cell cycle	cytosol|soluble fraction	asparagine synthase (glutamine-hydrolyzing) activity|ATP binding	p.R208L(1)		ovary(1)	1	all_cancers(62;6.64e-09)|all_epithelial(64;1.58e-09)|Esophageal squamous(72;0.00448)|Lung NSC(181;0.0342)|all_lung(186;0.0369)				Adenosine triphosphate(DB00171)|L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GGGTACATCCCGACAGTGATG	0.448000													5	146					0.00198382	0.00948867	0.00198382	1	0
GRIA4	2893	broad.mit.edu	37	11	105483100	105483100	+	Silent	SNP	T	T	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:105483100T>C	ENST00000393127.2	+	3	632	c.186T>C	c.(184-186)ttT>ttC	p.F62F	GRIA4_ENST00000525187.1_Silent_p.F62F|GRIA4_ENST00000527669.1_Silent_p.F62F|GRIA4_ENST00000393125.2_Silent_p.F62F|GRIA4_ENST00000428631.2_Silent_p.F62F|GRIA4_ENST00000530497.1_Silent_p.F62F|GRIA4_ENST00000282499.5_Silent_p.F62F	NM_001077243.2	NP_001070711.2	P48058	GRIA4_HUMAN	glutamate receptor, ionotropic, AMPA 4	62					glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(24)|liver(2)|lung(25)|ovary(4)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	82		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	AAGCTCCTTTTAATTTGGTAC	0.398000													31	47					0	0	0.000814825	0	0
INTS9	55756	broad.mit.edu	37	8	28627437	28627437	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr8:28627437G>A	ENST00000416984.2	-	15	2065	c.1706C>T	c.(1705-1707)cCt>cTt	p.P569L	INTS9_ENST00000397363.4_Missense_Mutation_p.P484L|INTS9_ENST00000521022.1_Missense_Mutation_p.P590L|INTS9_ENST00000521777.1_Missense_Mutation_p.P566L	NM_001145159.2	NP_001138631.1	Q9NV88	INT9_HUMAN	integrator complex subunit 9	590					snRNA processing	integrator complex	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|pancreas(2)|prostate(1)|urinary_tract(2)	19		Ovarian(32;0.0439)		KIRC - Kidney renal clear cell carcinoma(542;0.127)|Kidney(114;0.152)		CTGCTCCACAGGGATGGAACC	0.607000											OREG0018682	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	54					0	0	0.000586117	0	0
OR10G8	219869	broad.mit.edu	37	11	123901097	123901097	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:123901097C>T	ENST00000431524.1	+	1	801	c.768C>T	c.(766-768)ttC>ttT	p.F256F		NM_001004464.1	NP_001004464.1	Q8NGN5	O10G8_HUMAN	olfactory receptor, family 10, subfamily G, member 8	256					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(7)|large_intestine(2)|lung(21)|ovary(1)|prostate(5)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	44		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0521)		CTGGTCTTTTCATTTACCTGA	0.557000													8	65					0	0	0.000274275	0	0
OR2M3	127062	broad.mit.edu	37	1	248366917	248366917	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:248366917C>T	ENST00000456743.1	+	1	586	c.548C>T	c.(547-549)tCc>tTc	p.S183F		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			GACTTCCCCTCCCTACTAATC	0.413000													125	119					0	0	0.000781405	0	0
LINS	55180	broad.mit.edu	37	15	101109526	101109526	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:101109526G>A	ENST00000314742.8	-	7	2413	c.2191C>T	c.(2191-2193)Ctt>Ttt	p.L731F		NM_001040616.2	NP_001035706.1	Q8NG48	LINES_HUMAN	lines homolog (Drosophila)	731										central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(3)|ovary(1)|prostate(1)|skin(1)|stomach(4)	21						TATGGGAAAAGATTTTTCTTT	0.328000													29	79					0	0	0.00178596	0	0
OR13G1	441933	broad.mit.edu	37	1	247836218	247836218	+	Silent	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:247836218G>A	ENST00000359688.2	-	1	147	c.126C>T	c.(124-126)atC>atT	p.I42I	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005487.1	NP_001005487.1	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G, member 1	42					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(28)|skin(2)	35	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			TGGCAATGATGATGAGCATGT	0.423000													22	55					0	0	0.00229938	0	0
SMS	6611	broad.mit.edu	37	X	21997082	21997082	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:21997082C>T	ENST00000404933.2	+	7	1000	c.748C>T	c.(748-750)Cag>Tag	p.Q250*	SMS_ENST00000379404.1_Nonsense_Mutation_p.Q197*|SMS_ENST00000415881.2_Nonsense_Mutation_p.Q154*	NM_004595.4	NP_004586.2	P52788	SPSY_HUMAN	spermine synthase	250					methionine metabolic process|spermine biosynthetic process	cytosol	spermidine synthase activity|spermine synthase activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(2)|skin(2)	14					Spermine(DB00127)	AGACTGCTATCAGGTAATTGT	0.343000													19	88					0	0	0.00074312	0	0
NPAP1	23742	broad.mit.edu	37	15	24921643	24921643	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:24921643G>A	ENST00000329468.2	+	1	1103	c.629G>A	c.(628-630)gGa>gAa	p.G210E		NM_018958.2	NP_061831.2			nuclear pore associated protein 1																		CCTCTGGAGGGAAATGTCTAC	0.612000													8	29					0	0	0.000442599	0	0
MRAP2	112609	broad.mit.edu	37	6	84765113	84765113	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr6:84765113G>A	ENST00000257776.4	+	2	211	c.76G>A	c.(76-78)Gaa>Aaa	p.E26K		NM_138409.2	NP_612418.2	Q96G30	MRAP2_HUMAN	melanocortin 2 receptor accessory protein 2	26					positive regulation of cAMP biosynthetic process|protein localization at cell surface	endoplasmic reticulum|plasma membrane	corticotropin hormone receptor binding|type 1 melanocortin receptor binding|type 3 melanocortin receptor binding|type 4 melanocortin receptor binding|type 5 melanocortin receptor binding			NS(1)|breast(1)|endometrium(1)|large_intestine(4)|lung(4)|pancreas(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)	19						CTGGGAATATGAATATTATGA	0.383000													13	54					0	0	0.00136819	0	0
ADAP2	55803	broad.mit.edu	37	17	29283285	29283285	+	Silent	SNP	T	T	C			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:29283285T>C	ENST00000330889.3	+	10	1244	c.909T>C	c.(907-909)ttT>ttC	p.F303F	ADAP2_ENST00000580525.1_Silent_p.F309F	NM_018404.2	NP_060874.1	Q9NPF8	ADAP2_HUMAN	ArfGAP with dual PH domains 2	303	PH 2.				heart development|regulation of ARF GTPase activity	mitochondrial envelope|plasma membrane	ARF GTPase activator activity|inositol 1,3,4,5 tetrakisphosphate binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding, bridging|zinc ion binding	p.?(1)		breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	13						GCCAGGTTTTTCTTGGGAACA	0.592000													10	45					0	0	0.000978159	0	0
TMEM56	148534	broad.mit.edu	37	1	95657412	95657412	+	Silent	SNP	A	A	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:95657412A>G	ENST00000370203.4	+	7	1071	c.780A>G	c.(778-780)ggA>ggG	p.G260G	RP11-57H12.3_ENST00000419846.1_RNA|RP11-57H12.3_ENST00000421762.1_RNA|RP11-57H12.6_ENST00000604534.1_Intron	NM_001199679.1|NM_152487.2	NP_001186608.1|NP_689700.1	Q96MV1	TMM56_HUMAN	transmembrane protein 56	260						integral to membrane				breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)|skin(1)|urinary_tract(1)	12		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.133)		TTCAGAATGGAAAACTTGATT	0.363000													11	21					0	0	0.000673444	0	0
USH1C	10083	broad.mit.edu	37	11	17542914	17542914	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:17542914C>T	ENST00000005226.7	-	13	1063	c.1064G>A	c.(1063-1065)aGa>aAa	p.R355K	USH1C_ENST00000318024.4_Missense_Mutation_p.R355K|USH1C_ENST00000527020.1_Missense_Mutation_p.R336K|USH1C_ENST00000527720.1_Missense_Mutation_p.R324K	NM_153676.3	NP_710142.1	Q9Y6N9	USH1C_HUMAN	Usher syndrome 1C (autosomal recessive, severe)	355					equilibrioception|G2/M transition of mitotic cell cycle|photoreceptor cell maintenance|sensory perception of sound	apical part of cell|cytoplasm|stereocilium	protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(9)|lung(25)|ovary(1)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	48						CTTCCGGTATCTCTCATTTTC	0.502000													39	76					0	0	0.00195071	0	0
PLXNB3	5365	broad.mit.edu	37	X	153032887	153032887	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:153032887C>T	ENST00000538966.1	+	4	945	c.674C>T	c.(673-675)cCc>cTc	p.P225L	PLXNB3_ENST00000538282.1_Intron|PLXNB3_ENST00000538776.1_Intron|PLXNB3_ENST00000361971.5_Missense_Mutation_p.P202L|PLXNB3_ENST00000538543.1_Intron	NM_001163257.1	NP_001156729.1	Q9ULL4	PLXB3_HUMAN	plexin B3	202	Sema.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GGGGTGCCACCCCTGGCCATC	0.711000													4	25					0	0	0.00024832	0	0
AGPAT3	56894	broad.mit.edu	37	21	45402199	45402199	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr21:45402199C>T	ENST00000398063.2	+	9	1549	c.1057C>T	c.(1057-1059)Cgc>Tgc	p.R353C	AGPAT3_ENST00000546158.1_Missense_Mutation_p.R353C|AGPAT3_ENST00000327505.2_Missense_Mutation_p.R353C|AGPAT3_ENST00000291572.8_Missense_Mutation_p.R353C|AGPAT3_ENST00000398061.1_Missense_Mutation_p.R353C|AGPAT3_ENST00000398058.1_Missense_Mutation_p.R353C|AGPAT3_ENST00000479117.1_3'UTR	NM_001037553.1	NP_001032642.1	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	353					phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity	p.R353C(1)		large_intestine(4)|lung(5)|ovary(1)|prostate(1)	11				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		CTTTGGAGTTCGCAGACTGAT	0.448000													62	171					0	0	0.000781405	0	0
DDX10	1662	broad.mit.edu	37	11	108594053	108594053	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:108594053C>T	ENST00000526794.1	+	13	1861	c.1829C>T	c.(1828-1830)aCc>aTc	p.T610I	DDX10_ENST00000322536.3_Missense_Mutation_p.T610I			Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	610							ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity	p.E594_E618del(1)		breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		CTTCCTAACACCAGTGAGGCA	0.438000			T	NUP98	AML*								16	21					0	0	0.000958276	0	0
GFPT1	2673	broad.mit.edu	37	2	69556549	69556549	+	Silent	SNP	A	A	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:69556549A>T	ENST00000357308.4	-	17	1783	c.1605T>A	c.(1603-1605)atT>atA	p.I535I	GFPT1_ENST00000361060.4_Silent_p.I517I	NM_001244710.1	NP_001231639.1	Q06210	GFPT1_HUMAN	glutamine--fructose-6-phosphate transaminase 1	535					dolichol-linked oligosaccharide biosynthetic process|energy reserve metabolic process|fructose 6-phosphate metabolic process|glutamine metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	glutamine-fructose-6-phosphate transaminase (isomerizing) activity|sugar binding			endometrium(1)|large_intestine(3)|lung(5)|skin(3)	12						GTACTTCCTTAATCAAATCTA	0.318000													9	15					0	0	0.000274275	0	0
DSC1	1823	broad.mit.edu	37	18	28710596	28710596	+	Missense_Mutation	SNP	C	C	T	rs147309022		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr18:28710596C>T	ENST00000257198.5	-	16	2827	c.2566G>A	c.(2566-2568)Ggt>Agt	p.G856S	RP11-408H20.2_ENST00000581836.1_RNA|DSC1_ENST00000257197.3_3'UTR	NM_024421.2	NP_077739.1	Q08554	DSC1_HUMAN	desmocollin 1	856					homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			GCCAGAGAACCTTTGCCTTCA	0.438000													23	62					0	0	0.00229938	0	0
MAP3K10	4294	broad.mit.edu	37	19	40719021	40719021	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:40719021C>T	ENST00000253055.3	+	8	2051	c.1763C>T	c.(1762-1764)tCa>tTa	p.S588L		NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	588					activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						CAGTGGTCATCAAGTGCCCCC	0.622000													5	9					0	0	0.00116845	0	0
WIZ	58525	broad.mit.edu	37	19	15538022	15538022	+	Silent	SNP	T	T	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:15538022T>G	ENST00000389282.4	-	6	3636	c.3423A>C	c.(3421-3423)ccA>ccC	p.P1141P	WIZ_ENST00000263381.6_Silent_p.P284P|WIZ_ENST00000599686.2_Silent_p.P325P|WIZ_ENST00000545156.1_Silent_p.P455P|WIZ_ENST00000599910.1_Silent_p.P458P			O95785	WIZ_HUMAN	widely interspaced zinc finger motifs	1141	Pro-rich.					nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|skin(1)|stomach(1)|urinary_tract(1)	24						CCGGTGGTGGTGGCAACTTCT	0.652000													9	45					0	0	0.000978159	0	0
THRB	7068	broad.mit.edu	37	3	24231772	24231772	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:24231772C>T	ENST00000396671.2	-	5	424	c.76G>A	c.(76-78)Gac>Aac	p.D26N	THRB_ENST00000416420.1_Missense_Mutation_p.D26N|THRB_ENST00000356447.4_Missense_Mutation_p.D26N	NM_001128176.2	NP_001121648.1	P10828	THB_HUMAN	thyroid hormone receptor, beta	26	Modulating.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	enzyme binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|transcription corepressor activity|zinc ion binding	p.D26N(1)		central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(6)|pancreas(2)|prostate(1)|skin(3)	19					Levothyroxine(DB00451)|Liothyronine(DB00279)	AGCTTCCAGTCGTGTTCTCGG	0.493000													17	83					0	0	0.00074312	0	0
FCGBP	8857	broad.mit.edu	37	19	40408704	40408704	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr19:40408704G>A	ENST00000221347.6	-	8	4142	c.4135C>T	c.(4135-4137)Ccc>Tcc	p.P1379S		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1379	VWFD 3.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TAGTTTCCGGGGACGGTGACC	0.582000													34	54					0	0	0.00058488	0	0
OR51F2	119694	broad.mit.edu	37	11	4842792	4842792	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr11:4842792C>T	ENST00000322110.5	+	1	242	c.177C>T	c.(175-177)atC>atT	p.I59I	MMP26_ENST00000477339.1_Intron|MMP26_ENST00000380390.1_Intron	NM_001004753.1	NP_001004753.1	Q8NH61	O51F2_HUMAN	olfactory receptor, family 51, subfamily F, member 2	59					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(4)|large_intestine(3)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.0778)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATAGCATGATCCTGTTTGTGG	0.488000													16	153					0	0	0.000566183	0	0
SIKE1	80143	broad.mit.edu	37	1	115323135	115323135	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:115323135G>A	ENST00000369528.5	-	1	171	c.94C>T	c.(94-96)Cag>Tag	p.Q32*	SIKE1_ENST00000506320.1_5'UTR|SIKE1_ENST00000060969.5_Nonsense_Mutation_p.Q32*	NM_001102396.1|NM_025073.2	NP_001095866.1|NP_079349.2	Q9BRV8	SIKE1_HUMAN	suppressor of IKBKE 1	32						cytosol	protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(2)	6						GCCGCCGACTGATCCACCAGC	0.657000													14	29					0	0	0.00244969	0	0
CYP4Z1	199974	broad.mit.edu	37	1	47564867	47564867	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:47564867C>T	ENST00000334194.3	+	8	981	c.978C>T	c.(976-978)atC>atT	p.I326I	CYP4A22-AS1_ENST00000444042.2_lincRNA	NM_178134.2	NP_835235.1	Q86W10	CP4Z1_HUMAN	cytochrome P450, family 4, subfamily Z, polypeptide 1	326						endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			cervix(1)|large_intestine(4)|lung(4)|skin(1)|stomach(1)	11						TCTCCTGGATCCTTTACTGCT	0.478000													22	35					0	0	0.00229938	0	0
CLEC5A	23601	broad.mit.edu	37	7	141635657	141635657	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr7:141635657C>T	ENST00000546910.1	-	5	498	c.302G>A	c.(301-303)gGa>gAa	p.G101E	CLEC5A_ENST00000551012.2_Missense_Mutation_p.G78E|CLEC5A_ENST00000438351.1_Missense_Mutation_p.G78E|CLEC5A_ENST00000470595.1_Intron|CLEC5A_ENST00000439991.1_Intron	NM_013252.2	NP_037384.1	Q9NY25	CLC5A_HUMAN	C-type lectin domain family 5, member A	101	C-type lectin.				anti-apoptosis|cellular defense response|innate immune response|interspecies interaction between organisms|osteoblast development	cell surface|integral to plasma membrane	sugar binding|viral receptor activity			endometrium(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	10	Melanoma(164;0.0171)					GGATCCTTTTCCTTTGCAAAA	0.443000													48	76					0	0	0.000781405	0	0
TTN	7273	broad.mit.edu	37	2	179583666	179583666	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:179583666C>T	ENST00000589042.1	-	84	24485	c.24261G>A	c.(24259-24261)gtG>gtA	p.V8087V	TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000591111.1_Silent_p.V7770V|TTN_ENST00000359218.5_Intron|TTN_ENST00000460472.2_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000342992.6_Silent_p.V6843V	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7770	Ig-like 63.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCAAAACTTCCACAGAATCAG	0.473000													4	14					0	0	0.00024832	0	0
AIFM1	9131	broad.mit.edu	37	X	129263945	129263945	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:129263945C>T	ENST00000287295.3	-	15	2000	c.1770_splice	c.e15+1	p.K590_splice	AIFM1_ENST00000460436.2_Splice_Site_p.K251_splice|AIFM1_ENST00000440263.1_Splice_Site_p.K238_splice|AIFM1_ENST00000346424.2_Splice_Site_p.K303_splice|AIFM1_ENST00000319908.3_Splice_Site_p.K586_splice|AIFM1_ENST00000535724.1_3'UTR	NM_001130847.3|NM_004208.3	NP_001124319.1|NP_004199.1	O95831	AIFM1_HUMAN	apoptosis-inducing factor, mitochondrion-associated, 1	590					activation of caspase activity|apoptosis in response to endoplasmic reticulum stress|cell redox homeostasis|DNA damage response, signal transduction resulting in induction of apoptosis|DNA fragmentation involved in apoptotic nuclear change	cytosol|mitochondrial inner membrane|mitochondrial intermembrane space|nucleus|perinuclear region of cytoplasm	DNA binding|electron carrier activity|flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|liver(2)|lung(8)|ovary(4)|prostate(2)|urinary_tract(1)	30						AGGCACCTACCTTCCTTGCTA	0.502000													14	89					0	0	0.000566183	0	0
ITGA8	8516	broad.mit.edu	37	10	15639298	15639298	+	Splice_Site	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr10:15639298C>T	ENST00000378076.3	-	21	2472	c.2118_splice	c.e21-1	p.G707_splice	ITGA8_ENST00000477064.1_5'UTR	NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	707					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						GGTCGAAATCCCTACAATTGC	0.498000													22	31					0	0	0.00229938	0	0
TMC2	117532	broad.mit.edu	37	20	2591073	2591073	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:2591073C>T	ENST00000358864.1	+	12	1437	c.1422C>T	c.(1420-1422)atC>atT	p.I474I	TMC2_ENST00000496948.1_3'UTR	NM_080751.2	NP_542789.2	Q8TDI7	TMC2_HUMAN	transmembrane channel-like 2	474						integral to membrane				NS(1)|breast(3)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(14)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	35						AGGTAGAGATCGTGATGTCCC	0.512000													37	126					0	0	0.0025221	0	0
KNTC1	9735	broad.mit.edu	37	12	123034322	123034322	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:123034322C>T	ENST00000333479.7	+	13	1174	c.997C>T	c.(997-999)Ctc>Ttc	p.L333F	KNTC1_ENST00000450485.2_Missense_Mutation_p.L296F	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	333					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		GATGAAAAACCTCATGGTTTA	0.308000													3	8					0	0	6.4e-05	0	0
PLCB4	5332	broad.mit.edu	37	20	9402023	9402023	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:9402023C>T	ENST00000378501.2	+	23	2213	c.2198C>T	c.(2197-2199)aCc>aTc	p.T733I	PLCB4_ENST00000378473.3_Missense_Mutation_p.T745I|PLCB4_ENST00000414679.2_Missense_Mutation_p.T745I|PLCB4_ENST00000492632.1_3'UTR|PLCB4_ENST00000278655.4_Missense_Mutation_p.T733I|PLCB4_ENST00000334005.3_Missense_Mutation_p.T733I|PLCB4_ENST00000378493.1_Missense_Mutation_p.T733I	NM_000933.3	NP_000924.3	Q15147	PLCB4_HUMAN	phospholipase C, beta 4	733	C2.				intracellular signal transduction|lipid catabolic process	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|protein binding|signal transducer activity			NS(2)|breast(4)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(11)|liver(4)|lung(34)|ovary(3)|pancreas(1)|prostate(1)|skin(19)|upper_aerodigestive_tract(1)	87						CCCACTGACACCATACGTAAG	0.413000													23	47					0	0	0.00188189	0	0
UGT2B15	7366	broad.mit.edu	37	4	69535870	69535870	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:69535870G>A	ENST00000338206.5	-	1	476	c.467C>T	c.(466-468)cCc>cTc	p.P156L		NM_001076.3	NP_001067.2	P54855	UDB15_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B15	156					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity										CTCACCACAGGGATTAAGGGC	0.393000													92	244					0	0	0.000781405	0	0
OR13H1	347468	broad.mit.edu	37	X	130678868	130678868	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:130678868C>T	ENST00000338616.3	+	1	919	c.821C>T	c.(820-822)tCa>tTa	p.S274L		NM_001004486.1	NP_001004486.1	Q8NG92	O13H1_HUMAN	olfactory receptor, family 13, subfamily H, member 1	274					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15	Acute lymphoblastic leukemia(192;0.000636)					AAGTTTATCTCAGTGTTTTAT	0.433000													40	96					0	0	0.00195071	0	0
OR4M2	390538	broad.mit.edu	37	15	22369378	22369378	+	Missense_Mutation	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr15:22369378C>T	ENST00000332663.2	+	1	901	c.803C>T	c.(802-804)tCc>tTc	p.S268F	RP11-69H14.6_ENST00000558896.1_RNA	NM_001004719.2	NP_001004719.2	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M, member 2	268					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S268F(1)		NS(2)|endometrium(2)|kidney(4)|large_intestine(6)|lung(38)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(3)	63		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		GACTCGTTTTCCCTAGATAAA	0.423000													26	118					0	0	0.00106085	0	0
MORC1	27136	broad.mit.edu	37	3	108724118	108724118	+	Silent	SNP	C	C	T			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:108724118C>T	ENST00000232603.5	-	19	1894	c.1812G>A	c.(1810-1812)ttG>ttA	p.L604L	MORC1_ENST00000483760.1_Silent_p.L583L	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	604					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						ATTCATGCTTCAAGTCATCGC	0.343000													16	35					0	0	0.000566183	0	0
CSN2	1447	broad.mit.edu	37	4	70823276	70823276	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr4:70823276G>A	ENST00000353151.3	-	5	402	c.391C>T	c.(391-393)Cca>Tca	p.P131S		NM_001891.2	NP_001882.1	P05814	CASB_HUMAN	casein beta	131					calcium ion transport	extracellular region	calcium ion binding|enzyme inhibitor activity|transporter activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|skin(2)	12						GTGAGTTTTGGGATTTGAGGG	0.468000													13	45					0	0	0.00185496	0	0
OSBPL7	114881	broad.mit.edu	37	17	45892672	45892672	+	Missense_Mutation	SNP	G	G	A			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr17:45892672G>A	ENST00000007414.3	-	13	1357	c.1166C>T	c.(1165-1167)tCg>tTg	p.S389L	OSBPL7_ENST00000392507.3_Missense_Mutation_p.S389L	NM_145798.2	NP_665741.1	Q9BZF2	OSBL7_HUMAN	oxysterol binding protein-like 7	389					lipid transport		lipid binding			autonomic_ganglia(1)|endometrium(6)|kidney(2)|large_intestine(5)|liver(2)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32						GCTGGTCTGCGATAGCTGGGG	0.607000													6	11					0	0	0.000274275	0	0
C1orf173	127254	broad.mit.edu	37	1	75037784	75037784	+	Frame_Shift_Del	DEL	G	G	-			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr1:75037784delG	ENST00000326665.5	-	14	3828	c.3610delC	c.(3610-3612)tgfs	p.L1204fs	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1204	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CCTTCCTTCAGGGCCCTATTC	0.587													48	149	---	---	---	---					
KIAA1715	80856	broad.mit.edu	37	2	176857060	176857060	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr2:176857060delA	ENST00000272748.4	-	4	403	c.156delT	c.(154-156)gtfs	p.V52fs	KIAA1715_ENST00000535310.1_5'UTR|KIAA1715_ENST00000544803.1_Frame_Shift_Del_p.V52fs	NM_030650.1	NP_085153.1	Q9C0E8	LNP_HUMAN	KIAA1715	52						integral to membrane	protein binding			endometrium(1)|large_intestine(4)|lung(12)|ovary(2)|skin(1)	20			OV - Ovarian serous cystadenocarcinoma(117;0.0793)			ACAGATAGAGAACTGAGGAAT	0.323													14	40	---	---	---	---					
KLHL24	54800	broad.mit.edu	37	3	183390139	183390139	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr3:183390139delT	ENST00000454652.1	+	8	1855	c.1469delT	c.(1468-1470)atfs	p.I490fs	KLHL24_ENST00000242810.6_Frame_Shift_Del_p.I490fs|KLHL24_ENST00000476808.1_Frame_Shift_Del_p.I490fs			Q6TFL4	KLH24_HUMAN	kelch-like family member 24	490						axon|cytoplasm|perikaryon				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			GCTATCCCAATTGCCAAAAGG	0.348													9	72	---	---	---	---					
TPRN	286262	broad.mit.edu	37	9	140094220	140094221	+	Frame_Shift_Ins	INS	-	-	GG			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr9:140094220_140094221insGG	ENST00000409012.4	-	1	1029_1030	c.943_944insCC	c.(943-945)ccafs	p.P315fs	TPRN_ENST00000321773.2_Frame_Shift_Ins_p.P254fs|TPRN_ENST00000541945.1_Intron	NM_001128228.2	NP_001121700.2	Q4KMQ1	TPRN_HUMAN	taperin	315					sensory perception of sound	stereocilium				breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)	8						CCGGGCCTGGAGGTCCCCCAAG	0.653													9	23	---	---	---	---					
SLCO1C1	53919	broad.mit.edu	37	12	20874883	20874883	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:20874883delT	ENST00000381552.1	+	8	1289	c.921delT	c.(919-921)gafs	p.D307fs	SLCO1C1_ENST00000540354.1_Frame_Shift_Del_p.D258fs|SLCO1C1_ENST00000545604.1_Frame_Shift_Del_p.D307fs|SLCO1C1_ENST00000266509.2_Frame_Shift_Del_p.D307fs|SLCO1C1_ENST00000545102.1_Frame_Shift_Del_p.D189fs			Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family, member 1C1	307					sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			NS(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	60	Esophageal squamous(101;0.149)					GTAGAGAGGATTCTAATTCTT	0.398													9	33	---	---	---	---					
ERBB3	2065	broad.mit.edu	37	12	56490961	56490962	+	Frame_Shift_Ins	INS	-	-	G			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr12:56490961_56490962insG	ENST00000267101.3	+	20	2847_2848	c.2407_2408insG	c.(2407-2409)gggfs	p.G803fs	ERBB3_ENST00000553131.1_Frame_Shift_Ins_p.G44fs|ERBB3_ENST00000450146.2_Frame_Shift_Ins_p.G160fs|ERBB3_ENST00000415288.2_Frame_Shift_Ins_p.G744fs	NM_001982.3	NP_001973.2	P21860	ERBB3_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3	803	Protein kinase.				cranial nerve development|heart development|negative regulation of cell adhesion|negative regulation of neuron apoptosis|negative regulation of secretion|negative regulation of signal transduction|neuron apoptosis|phosphatidylinositol 3-kinase cascade|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of cell proliferation|Schwann cell differentiation|transmembrane receptor protein tyrosine kinase signaling pathway|wound healing	basolateral plasma membrane|extracellular space|integral to plasma membrane|receptor complex	ATP binding|growth factor binding|protein heterodimerization activity|protein homodimerization activity|protein tyrosine kinase activator activity|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(2)|lung(3)|ovary(1)|skin(1)|stomach(1)	8			OV - Ovarian serous cystadenocarcinoma(18;0.112)			GAGACAACACCGGGGGGCACTG	0.540													21	65	---	---	---	---					
SLC23A2	9962	broad.mit.edu	37	20	4850569	4850569	+	Frame_Shift_Del	DEL	G	G	-	rs138961929		TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chr20:4850569delG	ENST00000379333.1	-	12	1625	c.1233delC	c.(1231-1233)ccfs	p.P411fs	SLC23A2_ENST00000424750.2_Frame_Shift_Del_p.P297fs|SLC23A2_ENST00000338244.1_Frame_Shift_Del_p.P411fs|SLC23A2_ENST00000468355.1_5'UTR	NM_203327.1	NP_976072.1	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (ascorbic acid transporter), member 2	411					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity	p.I412fs*4(1)		endometrium(1)|kidney(3)|large_intestine(9)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						TTGCGTGGATGGGGGGGGGTG	0.527													9	156	---	---	---	---					
MAGEC1	9947	broad.mit.edu	37	X	140994844	140994846	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:140994844_140994846delCCT	ENST00000285879.4	+	4	1940_1942	c.1654_1656delCCT	c.(1654-1656)del	p.P553del	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	553							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TCCTCAGAGCCCTCCTCAGGGGG	0.567										HNSCC(15;0.026)			9	381	---	---	---	---					
CD99L2	83692	broad.mit.edu	37	X	149937526	149937528	+	In_Frame_Del	DEL	GGC	GGC	-	rs7877654	byFrequency	TCGA-DA-A1I5-06A-11D-A197-08	TCGA-DA-A1I5-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	21b8363b-b36f-42c6-a9f7-f103c1355869	13c2d362-fd77-48c1-a2bb-49d9e685b0b9	g.chrX:149937526_149937528delGGC	ENST00000370377.3	-	11	885_887	c.768_770delGCC	c.(766-771)ccc>cc	p.PP256del	CD99L2_ENST00000355149.3_In_Frame_Del_p.PP184del|CD99L2_ENST00000346693.4_5'UTR|CD99L2_ENST00000466436.1_In_Frame_Del_p.PP207del|CD99L2_ENST00000437787.2_In_Frame_Del_p.PP183del	NM_001242614.1|NM_031462.3	NP_001229543.1|NP_113650.2	Q8TCZ2	C99L2_HUMAN	CD99 molecule-like 2	256	Poly-Pro.				cell adhesion	cell junction|integral to membrane				endometrium(4)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					GGCTGGTTCGGGCGGCGGCGGCG	0.611													7	241	---	---	---	---					
