Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
DNAH8	1769	broad.mit.edu	37	6	38879298	38879298	+	Silent	SNP	T	T	C			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr6:38879298T>C	ENST00000359357.3	+	64	9398	c.9144T>C	c.(9142-9144)ggT>ggC	p.G3048G	DNAH8_ENST00000449981.2_Silent_p.G3265G|DNAH8_ENST00000441566.1_Silent_p.G3012G					dynein, axonemal, heavy chain 8											NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						TTATAAATGGTTATAAAAACA	0.363000													26	25					0	0	1	0	0
SPPL2B	56928	broad.mit.edu	37	19	2341061	2341061	+	RNA	SNP	G	G	A			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr19:2341061G>A	ENST00000452401.2	+	0	1033				AC005258.3_ENST00000590001.1_RNA			Q8TCT7	PSL1_HUMAN	signal peptide peptidase like 2B							Golgi membrane|integral to membrane	aspartic-type endopeptidase activity						Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTCCTCGGGTGCACCAGGGCT	0.716000													4	12					0	0	1	0	0
PRRC1	133619	broad.mit.edu	37	5	126860242	126860242	+	Silent	SNP	T	T	G			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr5:126860242T>G	ENST00000442138.2	+	3	269	c.123T>G	c.(121-123)tcT>tcG	p.S41S	PRRC1_ENST00000512635.2_Silent_p.S41S|PRRC1_ENST00000296666.8_Silent_p.S41S			Q96M27	PRRC1_HUMAN	proline-rich coiled-coil 1	41	Pro-rich.					Golgi apparatus				endometrium(1)|large_intestine(1)|lung(4)	6		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0851)|Epithelial(69;0.113)		GTTCTTTTTCTTCTCCAAATG	0.423000													45	104					0	0	1	0	0
PAPPA2	60676	broad.mit.edu	37	1	176525788	176525788	+	Missense_Mutation	SNP	C	C	G			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:176525788C>G	ENST00000367662.3	+	2	1494	c.330C>G	c.(328-330)gaC>gaG	p.D110E	PAPPA2_ENST00000367661.3_Missense_Mutation_p.D110E	NM_020318.2	NP_064714.2	Q9BXP8	PAPP2_HUMAN	pappalysin 2	110					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			NS(3)|breast(3)|central_nervous_system(7)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(19)|lung(136)|ovary(7)|pancreas(1)|prostate(4)|skin(10)|upper_aerodigestive_tract(8)|urinary_tract(1)	226						TTCCCCCAGACCTGACTGAAA	0.557000													21	283					0	0	1	0	0
ATP13A5	344905	broad.mit.edu	37	3	193081035	193081035	+	Missense_Mutation	SNP	G	G	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr3:193081035G>T	ENST00000342358.4	-	3	491	c.374C>A	c.(373-375)cCa>cAa	p.P125Q		NM_198505.2	NP_940907.2	Q4VNC0	AT135_HUMAN	ATPase type 13A5	125					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			NS(1)|autonomic_ganglia(2)|breast(1)|endometrium(6)|kidney(4)|large_intestine(15)|liver(2)|lung(26)|ovary(5)|prostate(1)|skin(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	76	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		TTTTAATTCTGGCTTTATTAA	0.383000													9	47					0.0692343	0.0708827	1	1	0
ZNF780A	284323	broad.mit.edu	37	19	40581529	40581529	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr19:40581529C>T	ENST00000450241.2	-	6	1029	c.718G>A	c.(718-720)Gta>Ata	p.V240I	AC005614.5_ENST00000595508.1_RNA|ZNF780A_ENST00000594395.1_Missense_Mutation_p.V275I|ZNF780A_ENST00000414720.2_Intron|ZNF780A_ENST00000595687.2_Missense_Mutation_p.V274I|ZNF780A_ENST00000455521.1_Missense_Mutation_p.V275I|ZNF780A_ENST00000340963.5_Missense_Mutation_p.V274I			O75290	Z780A_HUMAN	zinc finger protein 780A	274					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(7)|lung(16)|upper_aerodigestive_tract(3)|urinary_tract(1)	31	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TATGGTTTTACACCAGAATGA	0.388000													5	167					0	0	1	0	0
GNL1	2794	broad.mit.edu	37	6	30522855	30522855	+	Missense_Mutation	SNP	C	C	G			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr6:30522855C>G	ENST00000376621.3	-	3	1323	c.353G>C	c.(352-354)cGg>cCg	p.R118P		NM_005275.3	NP_005266.2	P36915	GNL1_HUMAN	guanine nucleotide binding protein-like 1	118					response to DNA damage stimulus|signal transduction|T cell mediated immunity	extracellular space|intracellular	GTP binding|structural molecule activity	p.R118L(1)|p.R118Q(1)		cervix(2)|endometrium(4)|large_intestine(1)|lung(10)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	25						ATACACCTCCCGGATGTCCAG	0.562000													28	105					0	0	1	0	0
OR51I1	390063	broad.mit.edu	37	11	5462323	5462323	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr11:5462323T>C	ENST00000380211.1	-	1	421	c.422A>G	c.(421-423)aAc>aGc	p.N141S	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_001005288.2	NP_001005288.1	Q9H343	O51I1_HUMAN	olfactory receptor, family 51, subfamily I, member 1	141					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	30		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAATATACGGTTGTGAGTGAG	0.478000													10	23					0	0	1	0	0
HSD17B7	51478	broad.mit.edu	37	1	162762536	162762536	+	Silent	SNP	A	A	G			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:162762536A>G	ENST00000367917.3	+	2	191	c.123A>G	c.(121-123)gcA>gcG	p.A41A	HSD17B7_ENST00000367915.1_Silent_p.A41A|HSD17B7_ENST00000254521.3_Silent_p.A41A|HSD17B7_ENST00000485405.1_3'UTR|HSD17B7_ENST00000367913.1_Silent_p.A41A			P56937	DHB7_HUMAN	hydroxysteroid (17-beta) dehydrogenase 7	41					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity			endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9	all_hematologic(112;0.115)				NADH(DB00157)	TGAGCAAGGCAGAAGCTGTCT	0.592000													20	44					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21230961	21230961	+	Missense_Mutation	SNP	C	C	A			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr2:21230961C>A	ENST00000233242.1	-	26	8906	c.8779G>T	c.(8779-8781)Ggg>Tgg	p.G2927W		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	2927					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TTCCATGACCCTTTTCCAGAA	0.488000													43	80					6.21074e-16	6.67655e-16	1	1	0
F5	2153	broad.mit.edu	37	1	169510463	169510463	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:169510463A>G	ENST00000367796.3	-	13	4081	c.3880T>C	c.(3880-3882)Ttc>Ctc	p.F1294L	F5_ENST00000367797.3_Missense_Mutation_p.F1289L			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	1289	35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GTCTGGCTGAAGTCTAGAGAA	0.517000													5	438					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196621001	196621001	+	Silent	SNP	T	T	G			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr2:196621001T>G	ENST00000312428.6	-	62	11542	c.11442A>C	c.(11440-11442)gcA>gcC	p.A3814A	DNAH7_ENST00000409063.1_Silent_p.A297A	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3814					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						TAGACATGACTGCAAGCCCCT	0.358000													12	43					0	0	1	0	0
RPS6KA5	9252	broad.mit.edu	37	14	91367019	91367019	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr14:91367019A>G	ENST00000261991.3	-	10	1354	c.1181T>C	c.(1180-1182)cTt>cCt	p.L394P	RPS6KA5_ENST00000536315.2_Missense_Mutation_p.L315P|RPS6KA5_ENST00000418736.2_Missense_Mutation_p.L394P	NM_004755.2	NP_004746.2	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 5	394					axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(8)|lung(8)|ovary(1)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		GTGAAACTGAAGAGGGTCTAT	0.388000													6	14					0	0	1	0	0
ZMAT4	79698	broad.mit.edu	37	8	40532282	40532282	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr8:40532282G>A	ENST00000297737.6	-	5	664	c.518C>T	c.(517-519)gCg>gTg	p.A173V	ZMAT4_ENST00000315769.7_Intron	NM_024645.2	NP_078921.1	Q9H898	ZMAT4_HUMAN	zinc finger, matrin-type 4	173						nucleus	DNA binding|zinc ion binding	p.A173V(1)		NS(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	18	Ovarian(28;0.00724)|Colorectal(14;0.0468)	all_cancers(7;0.00936)|all_epithelial(6;3.53e-06)|all_lung(54;0.0318)|Lung NSC(58;0.0919)|Esophageal squamous(32;0.15)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;0.00722)			AACTCTTGCCGCATTCTTTTT	0.478000													79	86					0	0	1	0	0
CD14	929	broad.mit.edu	37	5	140011717	140011717	+	Silent	SNP	C	C	T	rs150900616		TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr5:140011717C>T	ENST00000302014.6	-	2	1481	c.852G>A	c.(850-852)tcG>tcA	p.S284S	CD14_ENST00000401743.2_Silent_p.S284S	NM_000591.3	NP_000582.1	P08571	CD14_HUMAN	CD14 molecule	284					apoptosis|cellular response to lipopolysaccharide|cellular response to lipoteichoic acid|inflammatory response|innate immune response|phagocytosis|positive regulation of tumor necrosis factor production|Toll signaling pathway	anchored to membrane|plasma membrane	lipopolysaccharide binding|lipoteichoic acid binding|opsonin receptor activity|peptidoglycan receptor activity			endometrium(1)|large_intestine(1)|lung(3)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCCAGCGAACGACAGATTGA	0.617000													10	49					0	0	1	0	0
SOX7	83595	broad.mit.edu	37	8	10692194	10692194	+	Missense_Mutation	SNP	C	C	A			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr8:10692194C>A	ENST00000554914.1	-	2	201	c.111G>T	c.(109-111)atG>atT	p.M37I	PINX1_ENST00000520018.2_5'UTR|PINX1_ENST00000519088.1_Missense_Mutation_p.M37I|PINX1_ENST00000426190.2_Missense_Mutation_p.M35I|SOX7_ENST00000553390.1_Missense_Mutation_p.M37I|PINX1_ENST00000314787.3_Missense_Mutation_p.M37I			Q9BT81	SOX7_HUMAN	SRY (sex determining region Y)-box 7	0					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	20				COAD - Colon adenocarcinoma(149;0.0732)		TAGACCACCCCATCTTCTCTA	0.453000													5	26					1	1	1	1	0
IFT140	9742	broad.mit.edu	37	16	1568356	1568356	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr16:1568356G>A	ENST00000426508.2	-	30	4406	c.4043C>T	c.(4042-4044)aCg>aTg	p.T1348M	IFT140_ENST00000361339.5_Missense_Mutation_p.T542M	NM_014714.3	NP_055529.2	Q96RY7	IF140_HUMAN	intraflagellar transport 140 homolog (Chlamydomonas)	1348										breast(1)|central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(12)|lung(10)|ovary(5)|pancreas(1)|prostate(4)|skin(4)|stomach(2)|urinary_tract(1)	53		Hepatocellular(780;0.219)				CTCTGTGTACGTCCTGCCGAG	0.597000													6	25					0	0	1	0	0
PCDHGA2	56113	broad.mit.edu	37	5	140719816	140719816	+	Silent	SNP	T	T	C			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr5:140719816T>C	ENST00000394576.2	+	1	1278	c.1278T>C	c.(1276-1278)gaT>gaC	p.D426D	PCDHGA1_ENST00000517417.1_Intron	NM_018915.2	NP_061738.1														breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(20)|lung(32)|ovary(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCGCTAAAGATGGAGGGAACC	0.502000													11	47					0	0	1	0	0
PCDHGA8	9708	broad.mit.edu	37	5	140773913	140773913	+	Silent	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr5:140773913C>T	ENST00000398604.2	+	1	1533	c.1533C>T	c.(1531-1533)acC>acT	p.T511T	PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_032088.1	NP_114477.1														endometrium(6)|kidney(6)|large_intestine(6)|lung(30)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACTCTGACACCGGTGTCCTGT	0.602000													39	28					0	0	1	0	0
MST1L	11223	broad.mit.edu	37	1	17084270	17084270	+	RNA	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:17084270C>T	ENST00000455405.2	-	0	538																											CCCCAGCCTGCAATCTCACAC	0.582000													16	275					0	0	1	0	0
KIRREL3	84623	broad.mit.edu	37	11	126301339	126301339	+	Silent	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr11:126301339C>T	ENST00000525144.2	-	14	1920	c.1671G>A	c.(1669-1671)gcG>gcA	p.A557A	KIRREL3_ENST00000529097.2_Silent_p.A545A|KIRREL3_ENST00000525704.2_Silent_p.A557A|KIRREL3_ENST00000416561.2_Silent_p.A24A	NM_032531.3	NP_115920.1	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 (Drosophila)	557					hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|endometrium(5)|large_intestine(11)|lung(8)|ovary(3)|prostate(1)	29	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		CACAGCAGAACGCCACGATGG	0.617000													4	12					0	0	1	0	0
BMPER	168667	broad.mit.edu	37	7	34182916	34182916	+	Missense_Mutation	SNP	G	G	T	rs142055675		TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr7:34182916G>T	ENST00000297161.2	+	15	2194	c.1820G>T	c.(1819-1821)cGg>cTg	p.R607L	BMPER_ENST00000426693.1_Missense_Mutation_p.R607L	NM_133468.4	NP_597725.1	Q8N8U9	BMPER_HUMAN	BMP binding endothelial regulator	607					blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(24)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	48						GCATATACCCGGGCCTGCCAG	0.463000													15	46					2.32078e-09	2.46404e-09	1	1	0
CDH8	1006	broad.mit.edu	37	16	61761040	61761040	+	Silent	SNP	G	G	A			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr16:61761040G>A	ENST00000577390.1	-	9	2448	c.1494C>T	c.(1492-1494)tcC>tcT	p.S498S	CDH8_ENST00000584337.1_Silent_p.S498S|CDH8_ENST00000577730.1_Silent_p.S498S|CDH8_ENST00000299345.6_Silent_p.S498S	NM_001796.4	NP_001787.2	P55286	CADH8_HUMAN	cadherin 8, type 2	498	Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			biliary_tract(1)|breast(3)|cervix(1)|endometrium(7)|kidney(6)|large_intestine(22)|liver(2)|lung(49)|ovary(6)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(4)	112		Ovarian(137;0.0799)|Melanoma(118;0.16)		UCEC - Uterine corpus endometrioid carcinoma (183;0.196)|Epithelial(162;0.0155)|all cancers(182;0.0305)|OV - Ovarian serous cystadenocarcinoma(108;0.0499)|BRCA - Breast invasive adenocarcinoma(181;0.249)		CCTCATATTCGGATGCGAATT	0.388000													15	51					0	0	1	0	0
RHOQ	23433	broad.mit.edu	37	2	46770278	46770278	+	Silent	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr2:46770278C>T	ENST00000238738.4	+	1	412	c.93C>T	c.(91-93)aaC>aaT	p.N31N	RHOQ_ENST00000465198.1_Intron	NM_012249.3	NP_036381.2	P17081	RHOQ_HUMAN	ras homolog family member Q	31					cortical actin cytoskeleton organization|insulin receptor signaling pathway|negative regulation of establishment of protein localization in plasma membrane|positive regulation of filopodium assembly|positive regulation of glucose import|positive regulation of transcription from RNA polymerase II promoter|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	actin filament|cytosol|plasma membrane	GBD domain binding|GTP binding|GTPase activity|profilin binding			skin(2)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			GCTATGCCAACGACGCCTTCC	0.662000													12	94					0	0	1	0	0
DLL3	10683	broad.mit.edu	37	19	39994710	39994710	+	Splice_Site	SNP	G	G	C			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr19:39994710G>C	ENST00000205143.4	+	5	659		c.e5-1		DLL3_ENST00000356433.5_Splice_Site	NM_016941.3	NP_058637.1	Q9NYJ7	DLL3_HUMAN	delta-like 3 (Drosophila)						Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(4)|lung(7)	19	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GTCCCCCATAGTGGTGTGCCG	0.622000													7	29					0	0	1	0	0
CDK4	1019	broad.mit.edu	37	12	58145430	58145430	+	Translation_Start_Site	SNP	C	C	T	rs104894340		TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr12:58145430C>T	ENST00000540325.1	-	0	241				CDK4_ENST00000312990.6_Missense_Mutation_p.R24H|CDK4_ENST00000549606.1_Intron|CDK4_ENST00000257904.6_Missense_Mutation_p.R24H|CDK4_ENST00000551888.1_5'UTR			P11802	CDK4_HUMAN	cyclin-dependent kinase 4						cell division|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|positive regulation of fibroblast proliferation|regulation of gene expression|response to drug|S phase of mitotic cell cycle	cyclin-dependent protein kinase holoenzyme complex|cytosol|membrane	ATP binding|cyclin-dependent protein kinase activity|protein binding	p.R24L(1)		breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(2)	21	all_cancers(7;4.96e-69)|Lung NSC(6;5.5e-25)|all_lung(6;3.87e-23)|all_epithelial(6;1.66e-15)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;4.21e-120)|all cancers(5;3.75e-83)|BRCA - Breast invasive adenocarcinoma(9;0.0294)			GTGGGGATCACGGGCCTTGTA	0.557000			Mis			melanoma			Hereditary Melanoma				12	39					0	0	1	0	0
ZNF570	148268	broad.mit.edu	37	19	37974922	37974922	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr19:37974922G>A	ENST00000330173.1	+	5	927	c.398G>A	c.(397-399)gGc>gAc	p.G133D	ZNF570_ENST00000388801.3_5'UTR|ZNF570_ENST00000586475.1_Missense_Mutation_p.G189D	NM_144694.1	NP_653295.1	Q96NI8	ZN570_HUMAN	zinc finger protein 570	133					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(3)|large_intestine(6)|lung(12)|ovary(1)|prostate(1)|skin(1)	27			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAATGTGAGGGCTATTTTGAA	0.368000													15	54					0	0	1	0	0
GABRE	2564	broad.mit.edu	37	X	151128426	151128426	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chrX:151128426C>T	ENST00000370325.1	-	6	722	c.669G>A	c.(667-669)atG>atA	p.M223I	GABRE_ENST00000393914.3_Missense_Mutation_p.M30I|GABRE_ENST00000370328.3_Missense_Mutation_p.M223I			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	223					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					ACTTGTAGATCATCTCATTCT	0.413000													23	7					0	0	1	0	0
HTT	3064	broad.mit.edu	37	4	3123134	3123134	+	Silent	SNP	T	T	C			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr4:3123134T>C	ENST00000355072.5	+	9	1393	c.1248T>C	c.(1246-1248)cgT>cgC	p.R416R		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	416					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GCCGAAGCCGTAGTGGGAGTA	0.498000													6	33					0	0	1	0	0
TSPAN10	83882	broad.mit.edu	37	17	79615001	79615001	+	RNA	SNP	G	G	A			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr17:79615001G>A	ENST00000328585.4	+	0	835				TSPAN10_ENST00000572675.1_RNA	NM_031945.3	NP_114151.3	Q9H1Z9	TSN10_HUMAN	tetraspanin 10							integral to membrane				ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.175)|Lung NSC(278;0.192)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			CGACCCCCGCGAAGATGGAGC	0.652000													4	17					0	0	1	0	0
CDC14A	8556	broad.mit.edu	37	1	100949960	100949960	+	Missense_Mutation	SNP	A	A	T	rs140849467	byFrequency	TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:100949960A>T	ENST00000336454.3	+	11	1445	c.1090A>T	c.(1090-1092)Att>Ttt	p.I364F	CDC14A_ENST00000544534.1_Missense_Mutation_p.I364F|CDC14A_ENST00000542213.1_Missense_Mutation_p.I306F|RP5-837M10.4_ENST00000432210.1_RNA|CDC14A_ENST00000370125.2_3'UTR|CDC14A_ENST00000370124.3_Missense_Mutation_p.I364F|CDC14A_ENST00000361544.6_Missense_Mutation_p.I364F	NM_003672.3	NP_003663.2	Q9UNH5	CC14A_HUMAN	cell division cycle 14A	364					cell cycle|cell division|cell proliferation	centrosome|nucleus|spindle	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			breast(1)|endometrium(5)|kidney(6)|large_intestine(6)|lung(10)|skin(2)|urinary_tract(1)	31		all_epithelial(167;3.71e-06)|all_lung(203;0.00097)|Lung NSC(277;0.001)		Epithelial(280;0.0676)|all cancers(265;0.127)|COAD - Colon adenocarcinoma(174;0.201)|Lung(183;0.227)|Colorectal(144;0.241)		TGATATGTCTATTGGTGGAAA	0.368000													14	41					0	0	1	0	0
XIRP1	165904	broad.mit.edu	37	3	39225750	39225750	+	Silent	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr3:39225750C>T	ENST00000340369.3	-	2	5415	c.5187G>A	c.(5185-5187)gtG>gtA	p.V1729V	XIRP1_ENST00000421646.1_Silent_p.V412V|XIRP1_ENST00000396251.1_3'UTR	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1729	Interaction with FLNC.						actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GTTCAGGTTGCACAGAGCACT	0.572000													14	34					0	0	1	0	0
CRY1	1407	broad.mit.edu	37	12	107386774	107386774	+	Silent	SNP	G	G	A			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr12:107386774G>A	ENST00000008527.5	-	11	2493	c.1626C>T	c.(1624-1626)ggC>ggT	p.G542G		NM_004075.3	NP_004066.1	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	542					DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding	p.G542G(1)		NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|skin(1)	29						GCTGACTGTCGCCATGAGCAT	0.333000													3	29					0	0	1	0	0
SLC39A12	221074	broad.mit.edu	37	10	18289716	18289716	+	Missense_Mutation	SNP	C	C	G			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr10:18289716C>G	ENST00000377369.2	+	11	1994	c.1721C>G	c.(1720-1722)aCg>aGg	p.T574R	SLC39A12_ENST00000539911.1_Missense_Mutation_p.T440R|SLC39A12_ENST00000377371.3_Missense_Mutation_p.T573R|SLC39A12_ENST00000377374.4_Missense_Mutation_p.T537R	NM_001145195.1	NP_001138667.1	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter), member 12	574					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity	p.T537M(1)		NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|kidney(3)|large_intestine(5)|lung(38)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	60						GTGACCACTACGATTGCTATC	0.443000													4	19					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71713371	71713371	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr16:71713371C>T	ENST00000393524.2	-	6	1691	c.958G>A	c.(958-960)Gag>Aag	p.E320K	PHLPP2_ENST00000356272.3_Missense_Mutation_p.E320K|PHLPP2_ENST00000568954.1_Missense_Mutation_p.E320K|PHLPP2_ENST00000567016.1_Missense_Mutation_p.E355K|PHLPP2_ENST00000360429.3_Missense_Mutation_p.E320K			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	320						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						GTAGAGATCTCGCATAACAAT	0.378000													19	15					0	0	1	0	0
PCDH17	27253	broad.mit.edu	37	13	58208165	58208165	+	Silent	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr13:58208165C>T	ENST00000377918.3	+	1	1511	c.1485C>T	c.(1483-1485)ctC>ctT	p.L495L		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	495	Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GCTCTGTGCTCGCCCAGGATC	0.577000													6	40					0	0	1	0	0
YARS	8565	broad.mit.edu	37	1	33276308	33276308	+	Silent	SNP	T	T	C			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:33276308T>C	ENST00000373477.4	-	3	1172	c.264A>G	c.(262-264)gaA>gaG	p.E88E		NM_003680.3	NP_003671.1	P54577	SYYC_HUMAN	tyrosyl-tRNA synthetase	88					apoptosis|tyrosyl-tRNA aminoacylation	cytosol|extracellular space|nucleus|soluble fraction	ATP binding|interleukin-8 receptor binding|signal transducer activity|tRNA binding|tyrosine-tRNA ligase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|skin(2)|urinary_tract(1)	15		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)			L-Tyrosine(DB00135)	GTTCTAGAAGTTCCCATGGGG	0.468000													6	47					0	0	1	0	0
ADAM30	11085	broad.mit.edu	37	1	120438358	120438358	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:120438358T>C	ENST00000369400.1	-	1	760	c.602A>G	c.(601-603)cAc>cGc	p.H201R		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	201					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		GTACTTTGGGTGTTTATAGGA	0.403000													7	234					0	0	1	0	0
DHX9	1660	broad.mit.edu	37	1	182827968	182827968	+	Missense_Mutation	SNP	C	C	A			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:182827968C>A	ENST00000367549.3	+	10	1111	c.1001C>A	c.(1000-1002)cCt>cAt	p.P334H		NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	334	MTAD.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						CCTTGGTCACCTCCACAATCC	0.468000													29	45					5.77227e-19	6.28374e-19	1	1	0
GCN1L1	10985	broad.mit.edu	37	12	120589192	120589192	+	Missense_Mutation	SNP	G	G	C			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr12:120589192G>C	ENST00000300648.6	-	34	4078	c.4066C>G	c.(4066-4068)Cag>Gag	p.Q1356E		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1356					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					ACGGACTCCTGGACCTGGGGA	0.597000													4	16					0	0	1	0	0
FMO3	2328	broad.mit.edu	37	1	171076936	171076936	+	Missense_Mutation	SNP	G	G	A	rs72549325		TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:171076936G>A	ENST00000367755.4	+	4	553	c.442G>A	c.(442-444)Gga>Aga	p.G148R	FMO3_ENST00000392085.2_Missense_Mutation_p.G148R|FMO3_ENST00000538429.1_Missense_Mutation_p.G85R|FMO3_ENST00000542847.1_Missense_Mutation_p.G128R	NM_001002294.2	NP_001002294.1	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	148					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			endometrium(1)|kidney(1)|large_intestine(12)|lung(12)|skin(1)|stomach(2)|urinary_tract(2)	31	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGTTTGTTCCGGACATCATGT	0.403000													43	109					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175304874	175304874	+	Missense_Mutation	SNP	C	C	A			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:175304874C>A	ENST00000367674.1	-	20	4312	c.3604G>T	c.(3604-3606)Ggg>Tgg	p.G1202W	TNR_ENST00000263525.2_Missense_Mutation_p.G1202W	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	1202	Fibrinogen C-terminal.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					TCCACGTTCCCGAAGCCAACA	0.438000													51	121					6.09941e-20	6.72499e-20	1	1	0
THSD7A	221981	broad.mit.edu	37	7	11514055	11514055	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr7:11514055T>C	ENST00000423059.3	-	8	2409	c.2158A>G	c.(2158-2160)Acg>Gcg	p.T720A	AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	720	TSP type-1 7.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		TTCCAAGTCGTAGTTGTGTTG	0.522000										HNSCC(18;0.044)			10	151					0	0	1	0	0
ACSM5	54988	broad.mit.edu	37	16	20422908	20422908	+	Missense_Mutation	SNP	G	G	C			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr16:20422908G>C	ENST00000331849.4	+	2	249	c.102G>C	c.(100-102)aaG>aaC	p.K34N	ACSM5_ENST00000575584.1_Missense_Mutation_p.K34N	NM_017888.2	NP_060358.2	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	34					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(6)|lung(28)|ovary(3)|prostate(1)|skin(3)|urinary_tract(1)	51						TTCCTCAGAAGATCGTGGCCA	0.577000													11	37					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34258076	34258076	+	Missense_Mutation	SNP	G	G	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:34258076G>T	ENST00000373381.4	-	11	1674	c.1498C>A	c.(1498-1500)Ctg>Atg	p.L500M	CSMD2_ENST00000338325.1_Missense_Mutation_p.L108M	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	460	CUB 3.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				CCGACCGTCAGGGTGTCATAG	0.572000													11	46					1.58986e-06	1.66742e-06	1	1	0
PROX1	5629	broad.mit.edu	37	1	214170989	214170989	+	Missense_Mutation	SNP	T	T	G			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:214170989T>G	ENST00000366958.4	+	2	1719	c.1111T>G	c.(1111-1113)Ttt>Gtt	p.F371V	PROX1_ENST00000261454.4_Missense_Mutation_p.F371V|PROX1_ENST00000498508.2_Missense_Mutation_p.F371V|PROX1_ENST00000435016.1_Missense_Mutation_p.F371V	NM_001270616.1	NP_001257545.1	Q92786	PROX1_HUMAN	prospero homeobox 1	371					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(3)|prostate(2)|skin(4)	47				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		GGTCAAAGTCTTTTCGGCCAA	0.527000													42	58					0	0	1	0	0
UGT1A5	54579	broad.mit.edu	37	2	234622111	234622111	+	Silent	SNP	G	G	A	rs147117995	byFrequency	TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr2:234622111G>A	ENST00000373414.3	+	1	474	c.474G>A	c.(472-474)gcG>gcA	p.A158A	UGT1A6_ENST00000480628.1_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A10_ENST00000344644.5_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A6_ENST00000373424.1_Intron	NM_019078.1	NP_061951.1												p.A158A(1)		cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		ACCTCTGCGCGGCGGTGCTGG	0.493000													24	86					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348674	197348674	+	RNA	SNP	A	A	G	rs144273946	by1000genomes	TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr3:197348674A>G	ENST00000418868.1	-	0	585					NR_003266.2																						GGCTCTGTCCACCAAATGCAC	0.478000													5	88					0	0	1	0	0
MTTP	4547	broad.mit.edu	37	4	100532572	100532572	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr4:100532572T>C	ENST00000457717.1	+	15	2207	c.1951T>C	c.(1951-1953)Ttt>Ctt	p.F651L	MTTP_ENST00000265517.5_Missense_Mutation_p.F651L|RP11-766F14.1_ENST00000508578.1_RNA|MTTP_ENST00000511045.1_Missense_Mutation_p.F678L	NM_000253.2	NP_000244.2	P55157	MTP_HUMAN	microsomal triglyceride transfer protein	651	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(14)|lung(19)|ovary(4)|prostate(5)|skin(1)|urinary_tract(1)	57				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	CCTGAACATCTTTCAGTACAT	0.433000													14	52					0	0	1	0	0
FAM83B	222584	broad.mit.edu	37	6	54735162	54735162	+	Silent	SNP	T	T	C			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr6:54735162T>C	ENST00000306858.7	+	2	234	c.118T>C	c.(118-120)Tta>Cta	p.L40L		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	40										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					TGAACACGGGTTAGAAGCATA	0.373000													30	59					0	0	1	0	0
KRTAP5-1	387264	broad.mit.edu	37	11	1606171	1606171	+	Silent	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr11:1606171C>T	ENST00000382171.2	-	1	342	c.309G>A	c.(307-309)ggG>ggA	p.G103G	KRTAP5-AS1_ENST00000534077.1_RNA|KRTAP5-AS1_ENST00000532922.1_RNA|KRTAP5-AS1_ENST00000524947.1_RNA|KRTAP5-AS1_ENST00000424148.1_RNA	NM_001005922.1	NP_001005922.1	Q6L8H4	KRA51_HUMAN	keratin associated protein 5-1	103	8 X 4 AA repeats of C-C-X-P.					keratin filament				endometrium(3)|kidney(1)|lung(9)|skin(2)|upper_aerodigestive_tract(1)	16		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		CCTTGGAGCCCCCACAGGAGC	0.672000													4	40					0	0	1	0	0
ZNF488	118738	broad.mit.edu	37	10	48371226	48371226	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr10:48371226A>G	ENST00000395702.2	+	2	921	c.694A>G	c.(694-696)Act>Gct	p.T232A	ZNF488_ENST00000494156.1_3'UTR|ZNF488_ENST00000586537.1_Missense_Mutation_p.T125A			Q96MN9	ZN488_HUMAN	zinc finger protein 488	232					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(7)|ovary(2)	14						ACTCTGTAGCACTTTTCTGGG	0.567000													19	45					0	0	1	0	0
IL17RA	23765	broad.mit.edu	37	22	17589456	17589456	+	Silent	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr22:17589456C>T	ENST00000319363.6	+	13	1480	c.1347C>T	c.(1345-1347)cgC>cgT	p.R449R		NM_014339.5	NP_055154.3	Q96F46	I17RA_HUMAN	interleukin 17 receptor A	449	SEFIR.				fibroblast activation|positive regulation of interleukin-23 production	integral to plasma membrane	interleukin-17 receptor activity			endometrium(2)|large_intestine(8)|lung(16)|ovary(1)|skin(2)|stomach(1)	30		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.241)		TGTGCTCCCGCGGCACGCGCG	0.672000													4	31					0	0	1	0	0
HSPH1	10808	broad.mit.edu	37	13	31711467	31711467	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr13:31711467C>T	ENST00000320027.5	-	18	2909	c.2565G>A	c.(2563-2565)atG>atA	p.M855I	HSPH1_ENST00000380406.5_Missense_Mutation_p.M814I|HSPH1_ENST00000429785.2_Missense_Mutation_p.M674I|HSPH1_ENST00000445273.2_Missense_Mutation_p.M857I|HSPH1_ENST00000380405.4_Missense_Mutation_p.M811I	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	855					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		AGTCCAAGTCCATATTAACAG	0.299000													6	52					0	0	1	0	0
RTN3	10313	broad.mit.edu	37	11	63520108	63520108	+	Missense_Mutation	SNP	C	C	G			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr11:63520108C>G	ENST00000377819.5	+	5	3022	c.2868C>G	c.(2866-2868)gaC>gaG	p.D956E	RTN3_ENST00000354497.4_Intron|RTN3_ENST00000540798.1_Missense_Mutation_p.D844E|RTN3_ENST00000537981.1_Missense_Mutation_p.D160E|RTN3_ENST00000356000.3_Missense_Mutation_p.D179E|RTN3_ENST00000341307.2_Missense_Mutation_p.D160E|RTN3_ENST00000339997.4_Missense_Mutation_p.D937E	NM_001265589.1	NP_001252518.1	O95197	RTN3_HUMAN	reticulon 3	956	Reticulon.				apoptosis|endoplasmic reticulum tubular network organization|interspecies interaction between organisms|response to stress|vesicle-mediated transport	endoplasmic reticulum membrane|extracellular space|Golgi membrane|integral to membrane				cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	20						ATCTGGTTGACTCCTTGAAGG	0.413000													15	44					0	0	1	0	0
TWISTNB	221830	broad.mit.edu	37	7	19748461	19748461	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr7:19748461G>A	ENST00000222567.5	-	1	249	c.179C>T	c.(178-180)tCg>tTg	p.S60L		NM_001002926.1	NP_001002926.1	Q3B726	RPA43_HUMAN	TWIST neighbor	60						microtubule cytoskeleton|nucleolus	DNA-directed RNA polymerase activity			kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(2)	20						GTAGCGGGGCGACAGCGCGAT	0.582000											OREG0017879	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	92					0	0	1	0	0
C16orf59	80178	broad.mit.edu	37	16	2514205	2514205	+	Missense_Mutation	SNP	T	T	G			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr16:2514205T>G	ENST00000569496.1	+	9	1189	c.1130T>G	c.(1129-1131)cTg>cGg	p.L377R	C16orf59_ENST00000361837.4_Missense_Mutation_p.L377R|C16orf59_ENST00000483320.1_Missense_Mutation_p.L210R|C16orf59_ENST00000563531.1_Missense_Mutation_p.L377R			Q7L2K0	CP059_HUMAN	chromosome 16 open reading frame 59	377										lung(1)|skin(1)|urinary_tract(1)	3		Ovarian(90;0.17)				GTGGCTGTGCTGGACCAGCAG	0.642000													5	16					0	0	1	0	0
SGSM3	27352	broad.mit.edu	37	22	40797677	40797677	+	Missense_Mutation	SNP	C	C	A			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr22:40797677C>A	ENST00000248929.9	+	3	277	c.88C>A	c.(88-90)Cag>Aag	p.Q30K	SGSM3_ENST00000454798.2_Intron	NM_015705.4	NP_056520.2	Q96HU1	SGSM3_HUMAN	small G protein signaling modulator 3	30					cell cycle arrest|Rap protein signal transduction	cytoplasm	Rab GTPase activator activity|Rab GTPase binding			cervix(1)|endometrium(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|skin(6)	19						CAAGTACACGCAGGTATAGCA	0.587000													3	33					0.150653	0.152426	1	1	0
ALOX12B	242	broad.mit.edu	37	17	7990713	7990713	+	Silent	SNP	C	C	A	rs149687727		TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr17:7990713C>A	ENST00000319144.4	-	1	308	c.48G>T	c.(46-48)tcG>tcT	p.S16S		NM_001139.2	NP_001130.1	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	16	PLAT.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity	p.S16S(1)		endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|stomach(1)	16						CCCGTGTTCCCGACAAGAGGT	0.597000										Multiple Myeloma(8;0.094)			15	33					5.01169e-05	5.19284e-05	1	1	0
LAMC2	3918	broad.mit.edu	37	1	183212407	183212407	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:183212407C>T	ENST00000264144.4	+	23	3519	c.3454C>T	c.(3454-3456)Cag>Tag	p.Q1152*		NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	1152	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						GGCACGTCAGCAGAGGGGCCA	0.562000													4	104					0	0	1	0	0
RLN3	117579	broad.mit.edu	37	19	14141641	14141641	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr19:14141641C>T	ENST00000431365.2	+	2	367	c.310C>T	c.(310-312)Cga>Tga	p.R104*	RLN3_ENST00000585987.1_3'UTR	NM_080864.2	NP_543140.1	Q8WXF3	REL3_HUMAN	relaxin 3	104						extracellular region	hormone activity			endometrium(1)|lung(4)	5						TTACAGGGGGCGACCCAGCTG	0.622000													9	40					0	0	1	0	0
NRAS	4893	broad.mit.edu	37	1	115258744	115258744	+	Missense_Mutation	SNP	C	C	T	rs121434596		TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:115258744C>T	ENST00000369535.4	-	2	291	c.38G>A	c.(37-39)gGt>gAt	p.G13D		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	13			G -> D (in a patient with an autoimmune lymphoproliferative disorder).|G -> R (in colorectal cancer).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.G13D(188)|p.G13V(56)|p.G13A(16)|p.G13N(1)|p.G13Y(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		TTTCCCAACACCACCTGCTCC	0.498000	G13D(HDMYZ_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G13D(KMM1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G13D(MINO_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G13D(NCIH929_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G13V(AML193_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			246	41					0	0	1	0	0
AGRN	375790	broad.mit.edu	37	1	982066	982066	+	Silent	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:982066C>T	ENST00000379370.2	+	18	3251	c.3201C>T	c.(3199-3201)agC>agT	p.S1067S		NM_198576.3	NP_940978.2	O00468	AGRIN_HUMAN	agrin	1067	Ser/Thr-rich.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(2)|lung(20)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	42	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		ATGGAAGCAGCGATGAGGAAC	0.692000													3	16					0	0	1	0	0
THOP1	7064	broad.mit.edu	37	19	2811639	2811639	+	Silent	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr19:2811639C>T	ENST00000307741.6	+	12	2018	c.1815C>T	c.(1813-1815)taC>taT	p.Y605Y	THOP1_ENST00000395212.4_Silent_p.Y116Y|THOP1_ENST00000586677.1_Silent_p.Y484Y	NM_003249.3	NP_003240.1	P52888	THOP1_HUMAN	thimet oligopeptidase 1	605					proteolysis	cytoplasm	metal ion binding|metalloendopeptidase activity|protein binding			NS(1)|central_nervous_system(1)|endometrium(1)|lung(8)|ovary(2)|skin(1)	14				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGGTGGCTACGACGCCCAGT	0.612000													6	20					0	0	1	0	0
SRCIN1	80725	broad.mit.edu	37	17	36700203	36700203	+	Splice_Site	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr17:36700203C>T	ENST00000264659.7	-	18	3496	c.3270_splice	c.e18-1	p.S1091_splice	SRCIN1_ENST00000578925.1_Splice_Site_p.S1125_splice|SRCIN1_ENST00000398579.4_5'UTR	NM_025248.2	NP_079524.2	Q9C0H9	SRCN1_HUMAN	SRC kinase signaling inhibitor 1	963					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)	19						GCCTCCGCCACTCTGCAGGAA	0.637000													3	1					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587576	43587576	+	RNA	SNP	A	A	G	rs145439557	by1000genomes	TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr17:43587576A>G	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							tctgaaaagaaaagaaaaaaa	0.428000													4	25					0	0	1	0	0
LPAR6	10161	broad.mit.edu	37	13	48985942	48985942	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr13:48985942C>T	ENST00000378434.4	-	7	2242	c.618G>A	c.(616-618)atG>atA	p.M206I	RB1_ENST00000267163.4_Intron|LPAR6_ENST00000345941.2_Missense_Mutation_p.M206I	NM_005767.5	NP_005758.2	P43657	LPAR6_HUMAN	lysophosphatidic acid receptor 6	206						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled	p.0?(15)|p.?(4)		NS(1)|endometrium(1)|large_intestine(4)|lung(1)|ovary(4)|prostate(1)|skin(1)|urinary_tract(1)	14						TTTTTAGCACCATACTAGAAC	0.279000													5	28					0	0	1	0	0
STXBP5	134957	broad.mit.edu	37	6	147631261	147631261	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr6:147631261C>T	ENST00000367481.3	+	10	1067	c.959C>T	c.(958-960)aCt>aTt	p.T320I	STXBP5_ENST00000179882.6_5'UTR|STXBP5_ENST00000321680.6_Missense_Mutation_p.T320I|STXBP5_ENST00000367480.3_Missense_Mutation_p.T320I	NM_139244.4	NP_640337.3	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn)	320					exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(21)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	42		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		TCATATGATACTGTAGGAAGA	0.333000													15	56					0	0	1	0	0
TRPM3	80036	broad.mit.edu	37	9	73478014	73478014	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr9:73478014C>T	ENST00000377110.2	-	3	515	c.272G>A	c.(271-273)cGt>cAt	p.R91H	TRPM3_ENST00000377111.2_Missense_Mutation_p.R91H|TRPM3_ENST00000396283.1_5'UTR|TRPM3_ENST00000437699.3_5'UTR|TRPM3_ENST00000360823.2_5'UTR|TRPM3_ENST00000357533.2_Missense_Mutation_p.R93H|TRPM3_ENST00000361823.5_5'UTR|TRPM3_ENST00000377101.1_5'UTR|TRPM3_ENST00000423814.3_Missense_Mutation_p.R93H|TRPM3_ENST00000377105.1_5'UTR|TRPM3_ENST00000377106.1_5'UTR	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	91						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						GCCTATCAGACGCCCACAGCA	0.468000													21	22					0	0	1	0	0
TDRD3	81550	broad.mit.edu	37	13	61084778	61084778	+	Missense_Mutation	SNP	A	A	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr13:61084778A>T	ENST00000196169.3	+	10	1539	c.751A>T	c.(751-753)Agg>Tgg	p.R251W	TDRD3_ENST00000377894.2_Missense_Mutation_p.R251W|TDRD3_ENST00000535286.1_Missense_Mutation_p.R344W|TDRD3_ENST00000377881.2_Missense_Mutation_p.R251W	NM_001146071.1|NM_030794.2	NP_001139543.1|NP_110421.1	Q9H7E2	TDRD3_HUMAN	tudor domain containing 3	251					chromatin modification	cytoplasm|nucleus	chromatin binding|methylated histone residue binding|nucleic acid binding|transcription coactivator activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	40		Prostate(109;0.173)|Breast(118;0.174)		GBM - Glioblastoma multiforme(99;0.000291)		AGGAAAAGGCAGGGGGCGAAT	0.343000													19	13					0	0	1	0	0
OSBPL10	114884	broad.mit.edu	37	3	31789497	31789497	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr3:31789497G>A	ENST00000396556.2	-	5	967	c.845C>T	c.(844-846)tCt>tTt	p.S282F	OSBPL10_ENST00000467647.1_5'UTR|OSBPL10_ENST00000438237.2_Missense_Mutation_p.S218F	NM_017784.4	NP_060254.2	Q9BXB5	OSB10_HUMAN	oxysterol binding protein-like 10	282					lipid transport		lipid binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	34				STAD - Stomach adenocarcinoma(1;0.00406)		GGTGGCAGCAGAGGTAGCTTT	0.632000													16	55					0	0	1	0	0
MYOM2	9172	broad.mit.edu	37	8	1998896	1998896	+	Missense_Mutation	SNP	G	G	C			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr8:1998896G>C	ENST00000262113.4	+	2	157	c.16G>C	c.(16-18)Gtc>Ctc	p.V6L	MYOM2_ENST00000523438.1_Intron	NM_003970.2	NP_003961.2	P54296	MYOM2_HUMAN	myomesin 2	6					muscle contraction	myosin filament	structural constituent of muscle			autonomic_ganglia(2)|breast(4)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(11)|kidney(2)|large_intestine(17)|lung(39)|ovary(5)|prostate(1)|skin(10)|upper_aerodigestive_tract(3)	104		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		CCTTGTGACTGTCCCCTTCTA	0.488000													5	45					0	0	1	0	0
GORAB	92344	broad.mit.edu	37	1	170508539	170508539	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:170508539A>G	ENST00000367763.3	+	2	345	c.325A>G	c.(325-327)Act>Gct	p.T109A	GORAB_ENST00000465717.1_3'UTR|GORAB_ENST00000367762.1_Missense_Mutation_p.T109A	NM_152281.2	NP_689494.2	Q5T7V8	GORAB_HUMAN	golgin, RAB6-interacting	109						Golgi apparatus|nucleus				endometrium(2)|large_intestine(3)|liver(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	17						TTCTTCCCCTACTCTTCCGAG	0.473000													10	108					0	0	1	0	0
ZNF721	170960	broad.mit.edu	37	4	437304	437304	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr4:437304C>T	ENST00000338977.5	-	2	964	c.916G>A	c.(916-918)Gca>Aca	p.A306T	ZNF721_ENST00000511833.2_Missense_Mutation_p.A318T|ZNF721_ENST00000506646.1_Intron|ABCA11P_ENST00000451020.2_RNA|ZNF721_ENST00000507078.1_Intron					zinc finger protein 721											endometrium(2)|kidney(2)|large_intestine(15)|lung(6)|ovary(1)|skin(1)|stomach(5)|urinary_tract(1)	33						TAAAGGTTTGCGGACTGTCTA	0.408000													3	45					0	0	1	0	0
TEX2	55852	broad.mit.edu	37	17	62238236	62238236	+	Missense_Mutation	SNP	G	G	C			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr17:62238236G>C	ENST00000258991.3	-	8	2834	c.2750C>G	c.(2749-2751)aCc>aGc	p.T917S	TEX2_ENST00000584379.1_Missense_Mutation_p.T910S|TEX2_ENST00000583097.1_Missense_Mutation_p.T910S			Q8IWB9	TEX2_HUMAN	testis expressed 2	910					signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		ATTCATTTTGGTCTCGAGAGT	0.398000													14	81					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													4	23					0	0	1	0	0
PADI6	353238	broad.mit.edu	37	1	17723476	17723477	+	RNA	INS	-	-	CA	rs67024576	by1000genomes	TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:17723476_17723477insCA	ENST00000434762.2	+	0	1669							Q6TGC4	PADI6_HUMAN	peptidyl arginine deiminase, type VI						peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(9)|lung(9)|ovary(2)	29		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	AGGAATGCACCCAGGTGGCTGG	0.629													4	3	---	---	---	---					
ADAM30	11085	broad.mit.edu	37	1	120436591	120436591	+	Frame_Shift_Del	DEL	T	T	-			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:120436591delT	ENST00000369400.1	-	1	2527	c.2369delA	c.(2368-2370)agfs	p.K790fs		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	790					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		GCCCGGTTACTTTTTTTGTTT	0.358													7	829	---	---	---	---					
SRGAP2-AS1	100873165	broad.mit.edu	37	1	121116645	121116645	+	RNA	DEL	T	T	-			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:121116645delT	ENST00000437515.1	-	0	329																											CAAGCCCCCCTTTAAAAAAAA	0.393													7	72	---	---	---	---					
HIST2H2BB	338391	broad.mit.edu	37	1	149377834	149377839	+	RNA	DEL	TCTTTG	TCTTTG	-			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr1:149377834_149377839delTCTTTG	ENST00000415338.1	-	0	1061																											GTATCTCTTCTCTTTGTCTTTTTCTG	0.461													12	13	---	---	---	---					
SFRP1	6422	broad.mit.edu	37	8	41166638	41166640	+	In_Frame_Del	DEL	GCT	GCT	-	rs3055861		TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr8:41166638_41166640delGCT	ENST00000220772.3	-	1	376_378	c.39_41delAGC	c.(37-42)gcc>gc	p.AA13del		NM_003012.4	NP_003003.3	Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1	13					brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|liver(1)|lung(1)|skin(1)	7	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			CACGCCCAGGGCTGCCCCGCGGC	0.764													5	1	---	---	---	---					
POLDIP2	26073	broad.mit.edu	37	17	26684394	26684395	+	Splice_Site	INS	-	-	G	rs113730440		TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr17:26684394_26684395insG	ENST00000540200.1	-	1	78		c.e1+1		POLDIP2_ENST00000003607.4_5'UTR	NM_015584.3	NP_056399.1	Q9Y2S7	PDIP2_HUMAN	polymerase (DNA-directed), delta interacting protein 2							mitochondrial nucleoid|nucleus						all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		AGAGCGGCTTTGCCACCGGGCC	0.762													5	4	---	---	---	---					
ZNF567	163081	broad.mit.edu	37	19	37209935	37209936	+	Frame_Shift_Ins	INS	-	-	A			TCGA-EB-A44R-06A-41D-A25O-08	TCGA-EB-A44R-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	138BE5AA-3758-452E-BDDB-F7AE6181A935	65DFAA7E-4637-4556-9A97-4430C74BDAC2	g.chr19:37209935_37209936insA	ENST00000585696.1	+	3	1446_1447	c.216_217insA	c.(214-219)caaaaafs	p.QK72fs	ZNF567_ENST00000536254.2_Frame_Shift_Ins_p.QK103fs|ZNF567_ENST00000392163.2_Frame_Shift_Ins_p.QK72fs|ZNF850_ENST00000589390.1_Intron|ZNF567_ENST00000360729.4_Frame_Shift_Ins_p.QK72fs|ZNF567_ENST00000588311.1_Frame_Shift_Ins_p.QK72fs			Q8N184	ZN567_HUMAN	zinc finger protein 567	103	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			GCATCAACCACAAAAAACTGGT	0.327													11	38	---	---	---	---					
