Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MAP3K9	4293	broad.mit.edu	37	14	71209102	71209102	+	Missense_Mutation	SNP	C	C	A			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr14:71209102C>A	ENST00000554752.2	-	6	1532	c.1533G>T	c.(1531-1533)aaG>aaT	p.K511N	MAP3K9_ENST00000381250.4_Missense_Mutation_p.K511N|MAP3K9_ENST00000555993.2_Missense_Mutation_p.K511N|MAP3K9_ENST00000554146.1_Missense_Mutation_p.K248N|MAP3K9_ENST00000553414.1_Missense_Mutation_p.K205N			P80192	M3K9_HUMAN	mitogen-activated protein kinase kinase kinase 9	511				KLKDGNRISLPSDFQHKFTVQASPT -> AQPVLPFPHGHS RCPGGTGSSWGGQ (in Ref. 4).	activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		CATCCTTGAGCTTCAGCCGGC	0.592000													19	90					4.35082e-09	4.54858e-09	1	1	0
NCOA3	8202	broad.mit.edu	37	20	46262832	46262832	+	Silent	SNP	C	C	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr20:46262832C>T	ENST00000372004.3	+	10	1221	c.1005C>T	c.(1003-1005)ttC>ttT	p.F335F	NCOA3_ENST00000371997.3_Silent_p.F345F|NCOA3_ENST00000371998.3_Silent_p.F335F|NCOA3_ENST00000341724.6_Silent_p.F345F	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	335					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						TATATCGATTCTCGTTGGCTG	0.413000													20	94					0	0	1	0	0
NR0B2	8431	broad.mit.edu	37	1	27240111	27240111	+	Missense_Mutation	SNP	A	A	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr1:27240111A>T	ENST00000254227.3	-	1	346	c.321T>A	c.(319-321)ttT>ttA	p.F107L		NM_021969.2	NP_068804.1	Q15466	NR0B2_HUMAN	nuclear receptor subfamily 0, group B, member 2	107	Ligand-binding (By similarity).				cholesterol metabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	cytoplasm|nucleoplasm	DNA binding|protein domain specific binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription corepressor activity			NS(1)|large_intestine(1)|lung(3)	5		all_cancers(24;1.23e-26)|all_epithelial(13;1.19e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;0.00017)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;1.01e-51)|OV - Ovarian serous cystadenocarcinoma(117;8.22e-30)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		CAGCCACCTCAAAGGTCACAG	0.647000													6	21					0	0	1	0	0
MAN2A1	4124	broad.mit.edu	37	5	109049257	109049257	+	Missense_Mutation	SNP	T	T	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr5:109049257T>G	ENST00000261483.4	+	2	1224	c.172T>G	c.(172-174)Ttg>Gtg	p.L58V		NM_002372.2	NP_002363.2	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	58					mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		AATAGACCATTTGGAGCGTTT	0.378000													16	48					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593016	96593016	+	Missense_Mutation	SNP	C	C	A	rs79307257	by1000genomes	TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr2:96593016C>A	ENST00000456556.1	-	28	1969	c.1885G>T	c.(1885-1887)Gat>Tat	p.D629Y						ankyrin repeat domain 36C									p.D629Y(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GAAACAGAATCTTTCTCATCA	0.318000													4	41					0.184627	0.184627	1	1	0
TRIM37	4591	broad.mit.edu	37	17	57134361	57134361	+	Missense_Mutation	SNP	A	A	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr17:57134361A>T	ENST00000376149.3	-	13	1517	c.708T>A	c.(706-708)aaT>aaA	p.N236K	TRIM37_ENST00000262294.7_Missense_Mutation_p.N358K|TRIM37_ENST00000393065.2_Missense_Mutation_p.N324K|TRIM37_ENST00000393066.3_Missense_Mutation_p.N358K			O94972	TRI37_HUMAN	tripartite motif containing 37	358						perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(13)|ovary(1)|pancreas(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	37	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					CTCGAATGATATTTTTTGTAG	0.343000									Mulibrey Nanism				10	40					0	0	1	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240549	39240549	+	Missense_Mutation	SNP	C	C	G	rs151117992	by1000genomes	TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr17:39240549C>G	ENST00000391417.4	+	1	91	c.91C>G	c.(91-93)Cag>Gag	p.Q31E		NM_033061.3	NP_149050.3			keratin associated protein 4-7											NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						CAGCTGCTGTCAGACCACCTG	0.632000													4	44					0	0	1	0	0
ADNP	23394	broad.mit.edu	37	20	49511038	49511038	+	Silent	SNP	T	T	C			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr20:49511038T>C	ENST00000396029.3	-	5	780	c.213A>G	c.(211-213)acA>acG	p.T71T	ADNP_ENST00000349014.3_Silent_p.T71T|ADNP_ENST00000371602.4_Silent_p.T71T|ADNP_ENST00000396032.3_Silent_p.T71T	NM_015339.2	NP_056154.1	Q9H2P0	ADNP_HUMAN	activity-dependent neuroprotector homeobox	71						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(7)|kidney(1)|large_intestine(13)|lung(7)|ovary(2)|prostate(2)|skin(2)	39						AGAAAGGTTTTGTCCGATAGT	0.393000													8	42					0	0	1	0	0
PSMD3	5709	broad.mit.edu	37	17	38152483	38152483	+	Silent	SNP	C	C	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr17:38152483C>G	ENST00000264639.4	+	10	1542	c.1368C>G	c.(1366-1368)ggC>ggG	p.G456G	PSMD3_ENST00000541736.1_Silent_p.G318G	NM_002809.3	NP_002800.2	O43242	PSMD3_HUMAN	proteasome (prosome, macropain) 26S subunit, non-ATPase, 3	456	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|regulation of protein catabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	enzyme regulator activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Colorectal(19;0.000442)					ACGAGAAGGGCTATGTCCAAT	0.527000													37	114					0	0	1	0	0
RPGRIP1L	23322	broad.mit.edu	37	16	53726072	53726072	+	Silent	SNP	G	G	A			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr16:53726072G>A	ENST00000262135.4	-	4	528	c.435C>T	c.(433-435)taC>taT	p.Y145Y	RPGRIP1L_ENST00000564374.1_Silent_p.Y145Y|RPGRIP1L_ENST00000379925.3_Silent_p.Y145Y|RPGRIP1L_ENST00000563746.1_Silent_p.Y145Y	NM_001127897.1	NP_001121369.1	Q68CZ1	FTM_HUMAN	RPGRIP1-like	145					negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			endometrium(6)|kidney(3)|large_intestine(9)|lung(19)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(2)	46		all_cancers(37;0.0973)				GAGTTTGCCTGTAACCCTGGG	0.398000													50	104					0	0	1	0	0
NLRP8	126205	broad.mit.edu	37	19	56487562	56487562	+	Missense_Mutation	SNP	T	T	A			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr19:56487562T>A	ENST00000291971.3	+	8	2840	c.2769T>A	c.(2767-2769)aaT>aaA	p.N923K	NLRP8_ENST00000590542.1_Missense_Mutation_p.N904K	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	923						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TCTGTAAAAATAAAACCCTGA	0.413000													9	56					0	0	1	0	0
SEC31A	22872	broad.mit.edu	37	4	83778132	83778132	+	Silent	SNP	G	G	A	rs149546168	byFrequency	TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr4:83778132G>A	ENST00000432794.1	-	16	2017	c.1854C>T	c.(1852-1854)ttC>ttT	p.F618F	SEC31A_ENST00000508479.1_Silent_p.F618F|SEC31A_ENST00000348405.4_Silent_p.F579F|SEC31A_ENST00000395310.2_Silent_p.F618F|SEC31A_ENST00000505472.1_Silent_p.F618F|SEC31A_ENST00000505984.1_Silent_p.F579F|SEC31A_ENST00000500777.2_Silent_p.F579F|SEC31A_ENST00000448323.1_Silent_p.F618F|SEC31A_ENST00000326950.5_Silent_p.F579F|SEC31A_ENST00000443462.2_Silent_p.F613F|SEC31A_ENST00000355196.2_Silent_p.F618F|SEC31A_ENST00000311785.7_Silent_p.F618F|SEC31A_ENST00000513858.1_Silent_p.F579F|SEC31A_ENST00000264405.5_Silent_p.F351F|SEC31A_ENST00000509142.1_Silent_p.F618F|SEC31A_ENST00000508502.1_Silent_p.F618F			O94979	SC31A_HUMAN	SEC31 homolog A (S. cerevisiae)	618					COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding	p.F618F(2)	SEC31A/ALK(3)|SEC31A/JAK2(4)	breast(1)	1		Hepatocellular(203;0.114)				GGGATTTTGCGAAGTATTTTT	0.343000													23	21					0	0	1	0	0
KDM1B	221656	broad.mit.edu	37	6	18207632	18207632	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr6:18207632T>C	ENST00000388870.2	+	16	1904	c.1663T>C	c.(1663-1665)Tct>Cct	p.S555P	KDM1B_ENST00000297792.5_Missense_Mutation_p.S323P|KDM1B_ENST00000397244.1_Missense_Mutation_p.S323P|KDM1B_ENST00000546309.2_Intron			Q8NB78	KDM1B_HUMAN	lysine (K)-specific demethylase 1B	555					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			breast(2)|endometrium(5)|large_intestine(6)|lung(8)|skin(3)|upper_aerodigestive_tract(1)	25						TTCCCAGGTATCTGCTCGCTC	0.522000													6	63					0	0	1	0	0
RAD54B	25788	broad.mit.edu	37	8	95479763	95479763	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr8:95479763C>T	ENST00000336148.5	-	2	129	c.5G>A	c.(4-6)aGa>aAa	p.R2K	RAD54B_ENST00000297592.5_Missense_Mutation_p.R2K	NM_012415.3	NP_036547.1	O95073	FSBP_HUMAN	RAD54 homolog B (S. cerevisiae)	0					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(10)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			TGCAGATCGTCTCATATTCAG	0.378000								Direct reversal of damage;Homologous recombination					8	140					0	0	1	0	0
HIP1R	9026	broad.mit.edu	37	12	123339674	123339674	+	Splice_Site	SNP	A	A	C			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr12:123339674A>C	ENST00000253083.4	+	10	976	c.852_splice	c.e10+1	p.E284_splice		NM_003959.1	NP_003950.1	O75146	HIP1R_HUMAN	huntingtin interacting protein 1 related	284					receptor-mediated endocytosis	clathrin coated vesicle membrane|coated pit|perinuclear region of cytoplasm	actin binding|phosphatidylinositol binding			breast(1)|endometrium(5)|kidney(6)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	26	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;4.6e-05)|Epithelial(86;0.000119)|BRCA - Breast invasive adenocarcinoma(302;0.2)		CGGCTGCCCGAGGTACCACCC	0.637000													24	64					0	0	1	0	0
KIF18B	146909	broad.mit.edu	37	17	43008985	43008985	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr17:43008985C>T	ENST00000587309.1	-	11	1561	c.1538G>A	c.(1537-1539)gGg>gAg	p.G513E	KIF18B_ENST00000590129.1_Missense_Mutation_p.G522E|KIF18B_ENST00000438933.2_Missense_Mutation_p.G513E|KIF18B_ENST00000339151.4_Missense_Mutation_p.G513E|KIF18B_ENST00000593135.1_Missense_Mutation_p.G501E	NM_001264573.1	NP_001251503.1			kinesin family member 18B											breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(2)	21		Prostate(33;0.155)				AGAACGGTCCCCATCCAGTTC	0.572000													14	49					0	0	1	0	0
FRG1B	284802	broad.mit.edu	37	20	29625941	29625941	+	Missense_Mutation	SNP	A	A	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr20:29625941A>T	ENST00000278882.3	+	5	565	c.185A>T	c.(184-186)gAt>gTt	p.D62V	FRG1B_ENST00000439954.2_Missense_Mutation_p.D67V|FRG1B_ENST00000358464.4_Missense_Mutation_p.D62V														p.D62V(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGCATTCAGATGCAATTGGA	0.333000													4	61					0	0	1	0	0
STK16	8576	broad.mit.edu	37	2	220112399	220112399	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr2:220112399C>T	ENST00000409638.3	+	6	749	c.577C>T	c.(577-579)Cgg>Tgg	p.R193W	STK16_ENST00000409260.1_Missense_Mutation_p.R238W|STK16_ENST00000396738.2_Missense_Mutation_p.R193W|STK16_ENST00000409743.1_Intron|STK16_ENST00000409516.3_Missense_Mutation_p.R75W	NM_001008910.2	NP_001008910.1	O75716	STK16_HUMAN	serine/threonine kinase 16	193	Protein kinase.				protein complex assembly	membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GGCAGCCCAGCGGTGCACCAT	0.587000													4	11					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82784630	82784630	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr7:82784630G>A	ENST00000423517.2	-	2	1664	c.1327C>T	c.(1327-1329)Cag>Tag	p.Q443*	PCLO_ENST00000333891.8_Nonsense_Mutation_p.Q443*	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	394	10 X 10 AA tandem approximate repeats of P-A-K-P-Q-P-Q-Q-P-X.|Gln-rich.|Pro-rich.			A -> T (in Ref. 4; CAB60727).	cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GGCCCAGGCTGCTGAACTGGA	0.592000													15	74					0	0	1	0	0
HS3ST3A1	9955	broad.mit.edu	37	17	13503870	13503870	+	Missense_Mutation	SNP	C	C	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr17:13503870C>G	ENST00000284110.1	-	1	1374	c.577G>C	c.(577-579)Gac>Cac	p.D193H		NM_006042.1	NP_006033.1	Q9Y663	HS3SA_HUMAN	heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1	193						Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine 3-sulfotransferase 3 activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		all_lung(20;0.114)		UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		AGGCCCTTGTCGTAGCTGCGG	0.726000													3	4					0	0	1	0	0
TRAF3IP1	26146	broad.mit.edu	37	2	239253162	239253162	+	Nonsense_Mutation	SNP	C	C	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr2:239253162C>G	ENST00000373327.4	+	9	1406	c.1184C>G	c.(1183-1185)tCa>tGa	p.S395*	TRAF3IP1_ENST00000391993.3_Intron|TRAF3IP1_ENST00000391994.2_Nonsense_Mutation_p.S395*	NM_015650.3	NP_056465.2	Q8TDR0	MIPT3_HUMAN	TNF receptor-associated factor 3 interacting protein 1	395	DISC1-interaction domain.					cytoplasm|cytoskeleton	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|skin(2)	23		all_epithelial(40;3.22e-10)|Breast(86;0.000523)|Renal(207;0.00571)|Ovarian(221;0.156)|all_hematologic(139;0.182)		Epithelial(121;9.92e-24)|OV - Ovarian serous cystadenocarcinoma(60;7.85e-12)|Kidney(56;3.21e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.01e-07)|BRCA - Breast invasive adenocarcinoma(100;7.72e-05)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0184)		AATATTAACTCAACTAGTATT	0.403000													8	22					0	0	1	0	0
OBSCN	84033	broad.mit.edu	37	1	228474605	228474605	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr1:228474605G>A	ENST00000570156.2	+	40	10770	c.10696G>A	c.(10696-10698)Ggg>Agg	p.G3566R	OBSCN_ENST00000284548.11_Missense_Mutation_p.G3137R|OBSCN_ENST00000359599.6_Missense_Mutation_p.G1984R|OBSCN_ENST00000366709.4_Missense_Mutation_p.G256R|OBSCN_ENST00000422127.1_Missense_Mutation_p.G3137R|OBSCN_ENST00000366707.4_Missense_Mutation_p.G256R	NM_001271223.2	NP_001258152.2	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF	2599	Ig-like 36.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			NS(2)|breast(7)|central_nervous_system(5)|cervix(2)|endometrium(30)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(37)|lung(89)|ovary(8)|pancreas(3)|prostate(13)|skin(6)|stomach(11)|upper_aerodigestive_tract(2)|urinary_tract(3)	223		Prostate(94;0.0405)				GACCCTGCGGGGGTCTGCCCG	0.642000													5	31					0	0	1	0	0
ESPL1	9700	broad.mit.edu	37	12	53664186	53664186	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr12:53664186C>T	ENST00000257934.4	+	4	1259	c.1168C>T	c.(1168-1170)Cag>Tag	p.Q390*	ESPL1_ENST00000552462.1_Nonsense_Mutation_p.Q390*	NM_012291.4	NP_036423.4	Q14674	ESPL1_HUMAN	extra spindle pole bodies homolog 1 (S. cerevisiae)	390					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(10)|large_intestine(12)|lung(21)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(8)	70						CTCCAAGCAACAGCAGTCTTT	0.512000													26	102					0	0	1	0	0
GLUD1P7	414212	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	A	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr10:48968566A>G	ENST00000594520.1	+	0	723																											ACAGGATAACAAACTGGAAAA	0.318000													4	27					0	0	1	0	0
EDN1	1906	broad.mit.edu	37	6	12292703	12292703	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr6:12292703A>G	ENST00000379375.5	+	2	461	c.194A>G	c.(193-195)tAc>tGc	p.Y65C		NM_001168319.1|NM_001955.4	NP_001161791.1|NP_001946.3	P05305	EDN1_HUMAN	endothelin 1	65					artery smooth muscle contraction|calcium-mediated signaling|leukocyte activation|negative regulation of blood coagulation|negative regulation of cellular protein metabolic process|negative regulation of nitric-oxide synthase biosynthetic process|negative regulation of transcription from RNA polymerase II promoter|nitric oxide transport|peptide hormone secretion|phosphatidylinositol 3-kinase cascade|positive regulation of cardiac muscle hypertrophy|positive regulation of cell size|positive regulation of endothelial cell migration|positive regulation of heart rate|positive regulation of hormone secretion|positive regulation of JUN kinase activity|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of sarcomere organization|positive regulation of smooth muscle cell proliferation|prostaglandin biosynthetic process|protein kinase C deactivation|regulation of systemic arterial blood pressure by endothelin|regulation of vasoconstriction|vein smooth muscle contraction	cytoplasm|extracellular space	cytokine activity|endothelin A receptor binding|endothelin B receptor binding|hormone activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	13	all_cancers(95;0.241)|Breast(50;0.0266)|Ovarian(93;0.12)	all_hematologic(90;0.117)				GAGTGTGTCTACTTCTGCCAC	0.582000													21	73					0	0	1	0	0
C2CD2	25966	broad.mit.edu	37	21	43321836	43321836	+	Silent	SNP	C	C	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr21:43321836C>T	ENST00000380486.3	-	12	1696	c.1455G>A	c.(1453-1455)tcG>tcA	p.S485S	C2CD2_ENST00000329623.7_Silent_p.S330S	NM_015500.1	NP_056315.1	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2	485						cytosol|extracellular region|nucleus				endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|stomach(1)	15						CCACTGGATCCGAACCATTCA	0.428000													8	44					0	0	1	0	0
ALDH16A1	126133	broad.mit.edu	37	19	49971706	49971706	+	Silent	SNP	G	G	A			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr19:49971706G>A	ENST00000293350.4	+	15	2170	c.2007G>A	c.(2005-2007)ccG>ccA	p.P669P	ALDH16A1_ENST00000540132.1_Silent_p.P506P|ALDH16A1_ENST00000455361.2_Silent_p.P618P|CTD-3148I10.9_ENST00000599536.1_Intron|ALDH16A1_ENST00000433981.2_Silent_p.P504P	NM_153329.3	NP_699160.2	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	669							oxidoreductase activity|protein binding			cervix(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|skin(2)|urinary_tract(3)	20		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		TGGTGTGTCCGGACGAGTGGC	0.697000													19	186					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518628	113518628	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr7:113518628C>T	ENST00000284601.3	-	4	2587	c.2519G>A	c.(2518-2520)gGa>gAa	p.G840E		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	840					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						TGTTATATTTCCAGTGCCACA	0.373000													27	128					0	0	1	0	0
SMC1B	27127	broad.mit.edu	37	22	45749907	45749907	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr22:45749907A>G	ENST00000357450.4	-	21	3223	c.3224T>C	c.(3223-3225)aTc>aCc	p.I1075T	SMC1B_ENST00000404354.3_Missense_Mutation_p.I1075T	NM_148674.3	NP_683515.3	Q8NDV3	SMC1B_HUMAN	structural maintenance of chromosomes 1B	1075					chromosome organization|meiosis	chromosome, centromeric region|cytoplasm|meiotic cohesin complex|nucleus	ATP binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(15)|ovary(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0182)		ATCAATTGAGATTGAGACATG	0.433000													19	106					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33520479	33520479	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr17:33520479C>T	ENST00000297307.5	-	1	933	c.848G>A	c.(847-849)tGc>tAc	p.C283Y		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	283	DUF6 2.					integral to membrane											TAGGACAGCGCACACCAGGGC	0.582000													29	88					0	0	1	0	0
KRTAP4-7	100132476	broad.mit.edu	37	17	39240560	39240560	+	Silent	SNP	T	T	C			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr17:39240560T>C	ENST00000391417.4	+	1	102	c.102T>C	c.(100-102)tgT>tgC	p.C34C		NM_033061.3	NP_149050.3			keratin associated protein 4-7									p.C34C(2)		NS(1)|endometrium(3)|kidney(1)|lung(1)|prostate(2)|urinary_tract(1)	9						AGACCACCTGTTGCAGGACCA	0.647000													4	46					0	0	1	0	0
ATP6V1G1	9550	broad.mit.edu	37	9	117359956	117359956	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr9:117359956A>G	ENST00000374050.3	+	3	383	c.290A>G	c.(289-291)gAc>gGc	p.D97G		NM_004888.3	NP_004879.1	O75348	VATG1_HUMAN	ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1	97					cellular iron ion homeostasis|insulin receptor signaling pathway|proton transport|transferrin transport	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase complex	ATPase binding|hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances			endometrium(1)|lung(2)|prostate(1)|skin(1)	5						GAAGTCTTGGACAACCTCTTG	0.502000													9	30					0	0	1	0	0
PDE4D	5144	broad.mit.edu	37	5	58287686	58287686	+	Missense_Mutation	SNP	T	T	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr5:58287686T>G	ENST00000340635.6	-	8	1336	c.1161A>C	c.(1159-1161)aaA>aaC	p.K387N	PDE4D_ENST00000546160.1_Missense_Mutation_p.K326N|PDE4D_ENST00000358923.6_Missense_Mutation_p.K85N|PDE4D_ENST00000405755.2_Missense_Mutation_p.K265N|PDE4D_ENST00000360047.5_Missense_Mutation_p.K251N|PDE4D_ENST00000503258.1_Missense_Mutation_p.K257N|PDE4D_ENST00000507116.1_Missense_Mutation_p.K323N|PDE4D_ENST00000502484.2_Missense_Mutation_p.K326N|PDE4D_ENST00000317118.8_Missense_Mutation_p.K96N	NM_001104631.1	NP_001098101.1	Q08499	PDE4D_HUMAN	phosphodiesterase 4D, cAMP-specific	387					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|pancreas(1)	15		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	CTTGTTCAGTTTTAACTCCAA	0.358000													7	8					0	0	1	0	0
ABHD5	51099	broad.mit.edu	37	3	43756543	43756543	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr3:43756543A>G	ENST00000458276.2	+	5	889	c.766A>G	c.(766-768)Act>Gct	p.T256A		NM_016006.4	NP_057090.2	Q8WTS1	ABHD5_HUMAN	abhydrolase domain containing 5	256					cell differentiation|fatty acid metabolic process|negative regulation of sequestering of triglyceride|phosphatidic acid biosynthetic process|positive regulation of triglyceride catabolic process|triglyceride catabolic process	cytosol|lipid particle	1-acylglycerol-3-phosphate O-acyltransferase activity|lysophosphatidic acid acyltransferase activity			kidney(3)|large_intestine(2)|liver(2)|lung(5)|ovary(1)|skin(1)	14		Renal(3;0.0134)		KIRC - Kidney renal clear cell carcinoma(197;0.0546)|Kidney(197;0.0687)		TAATGTGCAGACTCCAAGGTG	0.393000													13	68					0	0	1	0	0
SLC1A6	6511	broad.mit.edu	37	19	15079275	15079275	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr19:15079275G>A	ENST00000598504.1	-	6	1747	c.388C>T	c.(388-390)Cgg>Tgg	p.R130W	SLC1A6_ENST00000600144.1_Missense_Mutation_p.R130W|SLC1A6_ENST00000430939.2_Intron|SLC1A6_ENST00000221742.3_Missense_Mutation_p.R130W|SLC1A6_ENST00000544886.2_Missense_Mutation_p.R130W	NM_001272087.1	NP_001259016.1	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6	130					synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			breast(1)|central_nervous_system(2)|endometrium(6)|large_intestine(8)|liver(1)|lung(12)|ovary(3)|pancreas(3)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	42					L-Glutamic Acid(DB00142)	ACAGCTGCCCGCATCCCCATC	0.607000													6	16					0	0	1	0	0
MPPED1	758	broad.mit.edu	37	22	43831006	43831006	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr22:43831006G>A	ENST00000417669.1	+	3	721	c.277G>A	c.(277-279)Gtc>Atc	p.V93I	MPPED1_ENST00000542779.1_Missense_Mutation_p.V93I|MPPED1_ENST00000443721.1_Missense_Mutation_p.V93I|MPPED1_ENST00000538182.1_Missense_Mutation_p.V126I|MPPED1_ENST00000414469.2_5'UTR|MPPED1_ENST00000439548.1_Intron			O15442	MPPD1_HUMAN	metallophosphoesterase domain containing 1	93							hydrolase activity			endometrium(3)|large_intestine(3)|lung(4)|prostate(2)|skin(1)	13		all_neural(38;0.0244)|Ovarian(80;0.0694)				CACCCGCTTCGTCTGCGTCTC	0.652000													22	117					0	0	1	0	0
SLC9B1	150159	broad.mit.edu	37	4	103867814	103867814	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr4:103867814A>G	ENST00000296422.7	-	5	656	c.515T>C	c.(514-516)cTc>cCc	p.L172P	SLC9B1_ENST00000394789.3_Missense_Mutation_p.L172P	NM_139173.3	NP_631912.2	Q4ZJI4	NHDC1_HUMAN	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	172						integral to membrane	solute:hydrogen antiporter activity										CTGTGGATCGAGTCCAAGCCC	0.348000													22	52					0	0	1	0	0
DDAH2	23564	broad.mit.edu	37	6	31696023	31696023	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr6:31696023C>T	ENST00000375792.3	-	5	1148	c.518G>A	c.(517-519)cGc>cAc	p.R173H	DDAH2_ENST00000480913.1_5'UTR|DDAH2_ENST00000375789.2_Missense_Mutation_p.R173H|DDAH2_ENST00000375787.2_Missense_Mutation_p.R173H			O95865	DDAH2_HUMAN	dimethylarginine dimethylaminohydrolase 2	173					anti-apoptosis|arginine catabolic process|citrulline metabolic process|nitric oxide biosynthetic process|nitric oxide mediated signal transduction	cytoplasm	dimethylargininase activity|protein binding			endometrium(1)|large_intestine(3)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	11					L-Citrulline(DB00155)	GCAGAGACCGCGCAGGTGGGA	0.672000													7	39					0	0	1	0	0
SH3PXD2A	9644	broad.mit.edu	37	10	105420799	105420799	+	Missense_Mutation	SNP	G	G	C			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr10:105420799G>C	ENST00000369774.4	-	8	822	c.546C>G	c.(544-546)aaC>aaG	p.N182K	SH3PXD2A_ENST00000540321.1_Missense_Mutation_p.N49K|SH3PXD2A_ENST00000355946.2_Missense_Mutation_p.N182K|SH3PXD2A_ENST00000315994.6_5'UTR|SH3PXD2A_ENST00000538130.1_Missense_Mutation_p.N17K|SH3PXD2A_ENST00000427662.2_Missense_Mutation_p.N44K			Q5TCZ1	SPD2A_HUMAN	SH3 and PX domains 2A	182	SH3 1.				cell communication|superoxide metabolic process	cell junction|cell projection|cytoplasm|podosome	phosphatidylinositol binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(18)|ovary(1)|skin(1)|urinary_tract(1)	38		Colorectal(252;0.0815)|Breast(234;0.131)		Epithelial(162;4.09e-10)|all cancers(201;2.73e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0119)		TCAGCTCCGAGTTCTCCTGCT	0.627000													32	133					0	0	1	0	0
SLC25A3	5250	broad.mit.edu	37	12	98992445	98992445	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr12:98992445C>T	ENST00000188376.5	+	4	959	c.605C>T	c.(604-606)gCa>gTa	p.A202V	SLC25A3_ENST00000228318.3_Missense_Mutation_p.A203V|SLC25A3_ENST00000552981.1_Missense_Mutation_p.A202V|SLC25A3_ENST00000551917.1_Missense_Mutation_p.A203V|SLC25A3_ENST00000549338.1_Missense_Mutation_p.A202V|SLC25A3_ENST00000548847.1_Missense_Mutation_p.A202V|SLC25A3_ENST00000401722.3_Missense_Mutation_p.A202V	NM_002635.3|NM_213611.2	NP_002626.1|NP_998776.1	Q00325	MPCP_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3	203					generation of precursor metabolites and energy	integral to plasma membrane|mitochondrial inner membrane	phosphate carrier activity|symporter activity			breast(1)|endometrium(2)|large_intestine(4)|lung(8)|prostate(1)	16		Lung NSC(355;4.08e-05)|Breast(359;0.00191)|Colorectal(145;0.00205)|Myeloproliferative disorder(1001;0.0255)		GBM - Glioblastoma multiforme(134;1.36e-23)|BRCA - Breast invasive adenocarcinoma(302;0.000115)		TTGAGGGATGCAGCTCCCAAA	0.388000													8	22					0	0	1	0	0
DUSP4	1846	broad.mit.edu	37	8	29207480	29207480	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr8:29207480T>C	ENST00000240100.2	-	1	705	c.316A>G	c.(316-318)Atc>Gtc	p.I106V		NM_001394.6	NP_001385.1	Q13115	DUS4_HUMAN	dual specificity phosphatase 4	106	Rhodanese.				endoderm formation|inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			endometrium(1)|large_intestine(1)|lung(4)	6				KIRC - Kidney renal clear cell carcinoma(542;0.094)|Kidney(114;0.113)		TCGTAGACGATGACCGCCGAG	0.736000													4	6					0	0	1	0	0
DAPK1	1612	broad.mit.edu	37	9	90311961	90311961	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr9:90311961C>T	ENST00000469640.2	+	22	2828	c.2453C>T	c.(2452-2454)cCt>cTt	p.P818L	DAPK1_ENST00000358077.5_Missense_Mutation_p.P818L|DAPK1_ENST00000408954.3_Missense_Mutation_p.P818L|DAPK1_ENST00000491893.1_Intron|DAPK1_ENST00000472284.1_Missense_Mutation_p.P818L			P53355	DAPK1_HUMAN	death-associated protein kinase 1	818					apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(27)|liver(2)|lung(17)|ovary(1)|prostate(2)|skin(3)|stomach(1)	72						TCTGGAAATCCTGTGTATTTC	0.393000									Chronic Lymphocytic Leukemia, Familial Clustering of				12	127					0	0	1	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55284920	55284920	+	Missense_Mutation	SNP	C	C	A			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr19:55284920C>A	ENST00000336077.6	+	3	246	c.206C>A	c.(205-207)aCt>aAt	p.T69N	KIR3DL1_ENST00000402254.2_Intron|KIR2DL4_ENST00000396284.2_Intron|KIR3DL1_ENST00000541392.1_Intron|KIR3DL1_ENST00000538269.1_Intron|KIR2DL3_ENST00000434419.2_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL1_ENST00000291633.7_Missense_Mutation_p.T69N	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	69	Ig-like C2-type 1.				immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		TTTAACGACACTTTGCGCCTC	0.517000													12	79					2.61681e-11	2.79938e-11	1	1	0
ZZEF1	23140	broad.mit.edu	37	17	4017708	4017708	+	Missense_Mutation	SNP	T	T	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr17:4017708T>G	ENST00000381638.2	-	4	875	c.751A>C	c.(751-753)Aag>Cag	p.K251Q	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	251	DOC.						calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						GCATAGCACTTTGCTACTGAC	0.438000													23	50					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69681869	69681869	+	Silent	SNP	A	A	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr4:69681869A>G	ENST00000265403.7	+	1	159	c.132A>G	c.(130-132)gaA>gaG	p.E44E	UGT2B10_ENST00000458688.2_Silent_p.E44E	NM_001075.4	NP_001066.1	P36537	UDB10_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B10	44					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						TCCTGAAAGAACTTGTTCAGA	0.423000													4	91					0	0	1	0	0
WDR91	29062	broad.mit.edu	37	7	134878103	134878103	+	Silent	SNP	C	C	T	rs148472782	byFrequency	TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr7:134878103C>T	ENST00000354475.4	-	11	1570	c.1539G>A	c.(1537-1539)tcG>tcA	p.S513S	WDR91_ENST00000423565.1_Silent_p.S478S|WDR91_ENST00000344400.5_Silent_p.S513S	NM_014149.3	NP_054868.3	A4D1P6	WDR91_HUMAN	WD repeat domain 91	513										breast(3)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	40						GAGCTGCTGCCGAACAGACGA	0.622000													5	52					0	0	1	0	0
OR4E2	26686	broad.mit.edu	37	14	22133491	22133491	+	Silent	SNP	T	T	C			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr14:22133491T>C	ENST00000408935.1	+	1	195	c.195T>C	c.(193-195)aaT>aaC	p.N65N		NM_001001912.1	NP_001001912.1	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E, member 2	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	15	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		TCCTGAGCAATCTGTCCTTTA	0.423000													46	201					0	0	1	0	0
MED23	9439	broad.mit.edu	37	6	131937080	131937080	+	Silent	SNP	A	A	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr6:131937080A>G	ENST00000403834.3	-	10	1016	c.843T>C	c.(841-843)gaT>gaC	p.D281D	MED23_ENST00000539158.1_Silent_p.D281D|MED23_ENST00000368068.3_Silent_p.D281D|MED23_ENST00000368058.1_Silent_p.D281D|MED23_ENST00000354577.4_Silent_p.D281D|MED23_ENST00000540546.1_Silent_p.D281D|MED23_ENST00000368053.4_Silent_p.D281D|MED23_ENST00000368060.3_Silent_p.D281D			Q9ULK4	MED23_HUMAN	mediator complex subunit 23	281					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor complex	protein binding|transcription coactivator activity			NS(1)|breast(3)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(12)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	44	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0115)|OV - Ovarian serous cystadenocarcinoma(155;0.0608)		TGCAGACCATATCCCTGGAAT	0.353000													3	39					0	0	1	0	0
TARS2	80222	broad.mit.edu	37	1	150468960	150468960	+	Missense_Mutation	SNP	C	C	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr1:150468960C>G	ENST00000369064.3	+	8	811	c.777C>G	c.(775-777)aaC>aaG	p.N259K	TARS2_ENST00000438568.2_3'UTR|TARS2_ENST00000606933.1_Intron|TARS2_ENST00000463555.1_Intron|TARS2_ENST00000369054.2_Intron	NM_025150.3	NP_079426.2	Q9BW92	SYTM_HUMAN	threonyl-tRNA synthetase 2, mitochondrial (putative)	259					threonyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|threonine-tRNA ligase activity			cervix(1)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	35	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.51e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)		L-Threonine(DB00156)	TCACACAGAACTCATCATCCT	0.493000													21	143					0	0	1	0	0
CXorf58	254158	broad.mit.edu	37	X	23933851	23933851	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chrX:23933851T>C	ENST00000379211.3	+	4	800	c.251T>C	c.(250-252)gTg>gCg	p.V84A		NM_001169574.1|NM_152761.2	NP_001163045.1|NP_689974.2	Q96LI9	CX058_HUMAN	chromosome X open reading frame 58	84										breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)	14						CTGAAGAAAGTGGCCCCCTTA	0.358000													6	22					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													4	40					0	0	1	0	0
RBM22	55696	broad.mit.edu	37	5	150076186	150076186	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr5:150076186G>A	ENST00000199814.4	-	6	575	c.454C>T	c.(454-456)Cgg>Tgg	p.R152W	RBM22_ENST00000540000.1_Missense_Mutation_p.R103W|RBM22_ENST00000447771.2_Missense_Mutation_p.R103W	NM_018047.2	NP_060517.1	Q9NW64	RBM22_HUMAN	RNA binding motif protein 22	152					protein import into nucleus, translocation	catalytic step 2 spliceosome|cytoplasm	calcium-dependent protein binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)|ovary(1)	17		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGTGTGGTCCGGGCCAGTTTG	0.507000													12	43					0	0	1	0	0
SPG11	80208	broad.mit.edu	37	15	44941192	44941192	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr15:44941192T>C	ENST00000261866.7	-	7	1490	c.1474A>G	c.(1474-1476)Att>Gtt	p.I492V	SPG11_ENST00000559193.1_Missense_Mutation_p.I492V|SPG11_ENST00000558319.1_Missense_Mutation_p.I492V|SPG11_ENST00000427534.2_Missense_Mutation_p.I492V|SPG11_ENST00000535302.2_Missense_Mutation_p.I492V	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	492					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		CCAAACAAAATCAGAGAGAGT	0.338000													7	17					0	0	1	0	0
C2CD2	25966	broad.mit.edu	37	21	43319241	43319241	+	Silent	SNP	G	G	A			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr21:43319241G>A	ENST00000380486.3	-	13	2032	c.1791C>T	c.(1789-1791)gtC>gtT	p.V597V	C2CD2_ENST00000329623.7_Silent_p.V442V	NM_015500.1	NP_056315.1	Q9Y426	CU025_HUMAN	C2 calcium-dependent domain containing 2	597						cytosol|extracellular region|nucleus				endometrium(2)|kidney(1)|large_intestine(4)|lung(3)|ovary(3)|prostate(1)|stomach(1)	15						GGTCCAGCAGGACCTGGCTGC	0.637000													4	74					0	0	1	0	0
CCDC105	126402	broad.mit.edu	37	19	15132166	15132166	+	Splice_Site	SNP	G	G	A			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr19:15132166G>A	ENST00000292574.3	+	4	958	c.874_splice	c.e4-1	p.A292_splice		NM_173482.2	NP_775753.2	Q8IYK2	CC105_HUMAN	coiled-coil domain containing 105	292					microtubule cytoskeleton organization	microtubule				NS(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(4)|skin(2)	23						CATTTGCAGCGTGCGCCTTGG	0.617000													4	31					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593025	96593025	+	Missense_Mutation	SNP	C	C	T	rs75189823	by1000genomes	TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr2:96593025C>T	ENST00000456556.1	-	28	1960	c.1876G>A	c.(1876-1878)Gat>Aat	p.D626N						ankyrin repeat domain 36C									p.D626N(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TCTTTCTCATCACTTGTAGCC	0.318000													4	42					0	0	1	0	0
SI	6476	broad.mit.edu	37	3	164781303	164781303	+	Missense_Mutation	SNP	T	T	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr3:164781303T>G	ENST00000264382.3	-	8	896	c.834A>C	c.(832-834)caA>caC	p.Q278H		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	278	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	TAAAGAATGTTTGATGGCCGT	0.239000										HNSCC(35;0.089)			14	66					0	0	1	0	0
FOXP2	93986	broad.mit.edu	37	7	114299424	114299424	+	Missense_Mutation	SNP	C	C	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr7:114299424C>G	ENST00000408937.3	+	13	1931	c.1557C>G	c.(1555-1557)aaC>aaG	p.N519K	FOXP2_ENST00000393489.3_Missense_Mutation_p.N402K|FOXP2_ENST00000393498.2_Missense_Mutation_p.N473K|FOXP2_ENST00000393491.3_Intron|FOXP2_ENST00000393494.2_Missense_Mutation_p.N494K|FOXP2_ENST00000393500.3_3'UTR|FOXP2_ENST00000350908.4_Missense_Mutation_p.N494K|FOXP2_ENST00000403559.4_Missense_Mutation_p.N511K	NM_001172766.2|NM_014491.3|NM_148898.3	NP_001166237.1|NP_055306.1|NP_683696.2	O15409	FOXP2_HUMAN	forkhead box P2	494					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						TTGCCCCAAACTATGAATTTT	0.274000													12	47					0	0	1	0	0
RORC	6097	broad.mit.edu	37	1	151785727	151785727	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr1:151785727A>G	ENST00000356728.6	-	7	1253	c.1099T>C	c.(1099-1101)Ttc>Ctc	p.F367L	RORC_ENST00000318247.6_Missense_Mutation_p.F388L|RORC_ENST00000392697.3_Missense_Mutation_p.F442L|RORC_ENST00000480719.1_5'UTR	NM_001001523.1	NP_001001523.1	P51449	RORG_HUMAN	RAR-related orphan receptor C	388	Ligand-binding.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|large_intestine(1)|lung(6)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			AAGGCTCGGAACAGCTCCATG	0.562000													7	398					0	0	1	0	0
KRTAP12-2	353323	broad.mit.edu	37	21	46086466	46086466	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr21:46086466A>G	ENST00000360770.3	-	1	378	c.338T>C	c.(337-339)gTc>gCc	p.V113A	TSPEAR_ENST00000323084.4_Intron	NM_181684.2	NP_859012.1	P59991	KR122_HUMAN	keratin associated protein 12-2	113	23 X 5 AA approximate repeats.					keratin filament				central_nervous_system(1)|endometrium(1)|lung(3)	5						CGCATACACGACAGGCCTGCA	0.632000													14	72					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100523393	100523393	+	Missense_Mutation	SNP	C	C	A	rs146761003		TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr8:100523393C>A	ENST00000358544.2	+	29	4472	c.4361C>A	c.(4360-4362)aCa>aAa	p.T1454K	VPS13B_ENST00000395996.1_3'UTR|VPS13B_ENST00000357162.2_Missense_Mutation_p.T1429K	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	1454					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTGACATACACAAAAGCTGTA	0.378000													14	83					9.05144e-12	9.79685e-12	1	1	0
ZNF10	7556	broad.mit.edu	37	12	133732769	133732769	+	Missense_Mutation	SNP	A	A	C			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr12:133732769A>C	ENST00000248211.6	+	5	1159	c.937A>C	c.(937-939)Aag>Cag	p.K313Q	ZNF10_ENST00000426665.2_Missense_Mutation_p.K313Q|ZNF10_ENST00000402932.2_Missense_Mutation_p.K179Q|CTD-2140B24.4_ENST00000540096.2_Intron|ZNF268_ENST00000416488.1_Intron	NM_015394.4	NP_056209.2	P21506	ZNF10_HUMAN	zinc finger protein 10	313					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(9)|prostate(1)|skin(5)|urinary_tract(1)	26	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		TGGACATCAAAAGACCCATAC	0.418000													16	54					0	0	1	0	0
ARHGEF15	22899	broad.mit.edu	37	17	8219100	8219100	+	Silent	SNP	G	G	A			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr17:8219100G>A	ENST00000361926.3	+	8	1559	c.1449G>A	c.(1447-1449)gtG>gtA	p.V483V	ARHGEF15_ENST00000421050.1_Silent_p.V483V	NM_173728.3	NP_776089.2	O94989	ARHGF_HUMAN	Rho guanine nucleotide exchange factor (GEF) 15	483	DH.				negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(1)|endometrium(9)|large_intestine(5)|lung(11)|ovary(5)|prostate(3)|skin(2)|urinary_tract(1)	37						TGTCCCGTGTGCGCTCTTCCC	0.572000													3	27					0	0	1	0	0
KCNAB3	9196	broad.mit.edu	37	17	7830986	7830986	+	Missense_Mutation	SNP	T	T	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr17:7830986T>G	ENST00000303790.2	-	3	312	c.313A>C	c.(313-315)Atc>Ctc	p.I105L	RP11-1099M24.7_ENST00000573621.1_3'UTR	NM_004732.3	NP_004723.2	O43448	KCAB3_HUMAN	potassium voltage-gated channel, shaker-related subfamily, beta member 3	105						cytoplasm|integral to membrane	oxidoreductase activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(2)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)	8		Prostate(122;0.157)				TCATCTGAGATCTGAGAACCA	0.493000													67	208					0	0	1	0	0
C9orf96	169436	broad.mit.edu	37	9	136269951	136269951	+	Missense_Mutation	SNP	G	G	A			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr9:136269951G>A	ENST00000371957.3	+	17	1878	c.1771G>A	c.(1771-1773)Ggc>Agc	p.G591S	C9orf96_ENST00000371955.1_Missense_Mutation_p.G124S	NM_153710.3	NP_714921.3	Q8NE28	SGK71_HUMAN	chromosome 9 open reading frame 96	591							ATP binding|protein kinase activity			autonomic_ganglia(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(10)|ovary(2)|stomach(2)	25				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		GGAGGAGGGCGGCAGTGGCCT	0.632000													19	91					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83847482	83847482	+	Missense_Mutation	SNP	A	A	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr6:83847482A>T	ENST00000349129.2	+	21	3981	c.3721A>T	c.(3721-3723)Att>Ttt	p.I1241F	DOPEY1_ENST00000369739.3_Missense_Mutation_p.I1232F|DOPEY1_ENST00000237163.5_Missense_Mutation_p.I1222F|DOPEY1_ENST00000484282.1_3'UTR	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	1241					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		CTCACCTTGTATTTCAGGAAC	0.428000													14	65					0	0	1	0	0
HNF1A	6927	broad.mit.edu	37	12	121426830	121426830	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr12:121426830C>T	ENST00000257555.6	+	2	747	c.521C>T	c.(520-522)gCg>gTg	p.A174V	HNF1A_ENST00000544413.1_Missense_Mutation_p.A174V|HNF1A_ENST00000543427.1_Missense_Mutation_p.A57V|HNF1A_ENST00000402929.1_Missense_Mutation_p.A174V|HNF1A_ENST00000400024.2_Missense_Mutation_p.A174V|HNF1A_ENST00000541395.1_Missense_Mutation_p.A174V|HNF1A_ENST00000538626.1_Intron			P20823	HNF1A_HUMAN	HNF1 homeobox A	174					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding	p.A174V(1)		breast(3)|central_nervous_system(2)|cervix(1)|endometrium(8)|large_intestine(19)|liver(175)|lung(9)|ovary(2)|prostate(1)|urinary_tract(1)	221	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CGAGAGGTGGCGCAGCGTAAG	0.612000									Hepatic Adenoma, Familial Clustering of				7	30					0	0	1	0	0
N4BP1	9683	broad.mit.edu	37	16	48594763	48594763	+	Silent	SNP	T	T	C			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr16:48594763T>C	ENST00000262384.3	-	2	2027	c.1791A>G	c.(1789-1791)cgA>cgG	p.R597R	RP11-44I10.3_ENST00000563994.1_RNA	NM_153029.3	NP_694574.3	O75113	N4BP1_HUMAN	NEDD4 binding protein 1	597					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body				breast(3)|kidney(2)|lung(11)|urinary_tract(1)	17		all_cancers(37;0.179)|all_lung(18;0.11)				TTAGAGTATCTCGAAACCTTT	0.428000													10	50					0	0	1	0	0
NDUFS8	4728	broad.mit.edu	37	11	67803764	67803764	+	Silent	SNP	G	G	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr11:67803764G>T	ENST00000313468.5	+	6	524	c.417G>T	c.(415-417)cgG>cgT	p.R139R	NDUFS8_ENST00000528492.1_5'UTR|NDUFS8_ENST00000526542.1_3'UTR	NM_002496.3	NP_002487.1	O00217	NDUS8_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)	139					mitochondrial electron transport, NADH to ubiquinone|mitochondrial respiratory chain complex I assembly|response to oxidative stress|transport	mitochondrial respiratory chain complex I	4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity			endometrium(1)|kidney(1)|lung(5)|skin(1)	8					NADH(DB00157)	GCAGCCGCCGGACCACCCGCT	0.662000													4	13					0.000602214	0.000622514	1	1	0
ARFGEF2	10564	broad.mit.edu	37	20	47580376	47580376	+	Missense_Mutation	SNP	A	A	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr20:47580376A>G	ENST00000371917.4	+	7	848	c.848A>G	c.(847-849)gAc>gGc	p.D283G		NM_006420.2	NP_006411.2	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)	283					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(7)|cervix(2)|endometrium(8)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	63			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			GGGACTGATGACGGAGCCCAG	0.448000													5	26					0	0	1	0	0
HIRIP3	8479	broad.mit.edu	37	16	30006059	30006059	+	Nonsense_Mutation	SNP	G	G	C			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr16:30006059G>C	ENST00000279392.3	-	4	1237	c.407C>G	c.(406-408)tCa>tGa	p.S136*	HIRIP3_ENST00000564026.1_Intron	NM_003609.4	NP_003600.2	Q9BW71	HIRP3_HUMAN	HIRA interacting protein 3	136	Glu-rich.				chromatin assembly or disassembly	nucleus	protein binding			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|liver(1)|lung(9)	17						AACTGCCTTTGAGGCTCGCCT	0.597000													8	110					0	0	1	0	0
FNDC7	163479	broad.mit.edu	37	1	109273432	109273432	+	Silent	SNP	T	T	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr1:109273432T>G	ENST00000370017.3	+	9	2038	c.1761T>G	c.(1759-1761)acT>acG	p.T587T	FNDC7_ENST00000271311.2_Silent_p.T588T	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	588	Fibronectin type-III 7.					extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		AGTGTCACACTCATCAAAACC	0.478000													12	47					0	0	1	0	0
LRRC37A4P	55073	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													4	47					0	0	1	0	0
SLC24A1	9187	broad.mit.edu	37	15	65918233	65918233	+	Silent	SNP	T	T	C			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr15:65918233T>C	ENST00000261892.6	+	2	2102	c.1815T>C	c.(1813-1815)caT>caC	p.H605H	SLC24A1_ENST00000399033.4_Silent_p.H605H|SLC24A1_ENST00000339868.6_Silent_p.H605H|SLC24A1_ENST00000546330.1_Silent_p.H605H|SLC24A1_ENST00000544319.2_Silent_p.H605H|SLC24A1_ENST00000537259.1_Silent_p.H605H	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	605					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						GGAACAAGCATATCGAGGTCT	0.542000													6	99					0	0	1	0	0
KRT2	3849	broad.mit.edu	37	12	53045434	53045434	+	Missense_Mutation	SNP	C	C	T			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr12:53045434C>T	ENST00000309680.3	-	1	514	c.493G>A	c.(493-495)Gtg>Atg	p.V165M		NM_000423.2	NP_000414.2	P35908	K22E_HUMAN	keratin 2	165	Head.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(18)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	32				BRCA - Breast invasive adenocarcinoma(357;0.19)		TCAACTTTCACGTTGAGAGGC	0.522000													26	79					0	0	1	0	0
F8	2157	broad.mit.edu	37	X	154133231	154133231	+	Missense_Mutation	SNP	T	T	C			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chrX:154133231T>C	ENST00000360256.4	-	16	5641	c.5441A>G	c.(5440-5442)gAt>gGt	p.D1814G		NM_000132.3	NP_000123.1	P00451	FA8_HUMAN	coagulation factor VIII, procoagulant component	1814	F5/8 type A 3.|Plastocyanin-like 5.				acute-phase response|blood coagulation, intrinsic pathway|cell adhesion|platelet activation|platelet degranulation	extracellular space|plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity|protein binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(27)|liver(1)|lung(47)|ovary(5)|pancreas(3)|prostate(1)|skin(5)|upper_aerodigestive_tract(5)|urinary_tract(2)	120	all_cancers(53;7.19e-17)|all_epithelial(53;9.83e-11)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)	TTGCCTCTGATCTTCCTCATA	0.373000													7	45					0	0	1	0	0
DDHD1	80821	broad.mit.edu	37	14	53619556	53619556	+	Missense_Mutation	SNP	C	C	G			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr14:53619556C>G	ENST00000357758.3	-	1	444	c.261G>C	c.(259-261)gaG>gaC	p.E87D	DDHD1_ENST00000395606.1_Missense_Mutation_p.E87D|DDHD1_ENST00000323669.5_Missense_Mutation_p.E87D	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	87					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					AGTCATAGTTCTCGTCACTGA	0.706000													3	26					0	0	1	0	0
TUBA3C	7278	broad.mit.edu	37	13	19751332	19751332	+	Missense_Mutation	SNP	C	C	A			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr13:19751332C>A	ENST00000400113.3	-	4	895	c.791G>T	c.(790-792)cGc>cTc	p.R264L		NM_006001.2	NP_005992.1	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	264					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity	p.R264H(1)		NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(33)|ovary(4)|prostate(7)|skin(7)|urinary_tract(1)	72		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		GAAGTGGATGCGGGGGTACGG	0.612000													29	48					7.11191e-15	7.78923e-15	1	1	0
PRDM16	63976	broad.mit.edu	37	1	3313064	3313064	+	Frame_Shift_Del	DEL	A	A	-			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr1:3313064delA	ENST00000378398.3	+	6	668	c.586delA	c.(586-588)aafs	p.K196fs	PRDM16_ENST00000512462.1_3'UTR|PRDM16_ENST00000442529.2_Frame_Shift_Del_p.K195fs|PRDM16_ENST00000441472.2_Frame_Shift_Del_p.K195fs|PRDM16_ENST00000514189.1_Frame_Shift_Del_p.K196fs|PRDM16_ENST00000511072.1_Frame_Shift_Del_p.K196fs|PRDM16_ENST00000378391.2_Frame_Shift_Del_p.K195fs|PRDM16_ENST00000270722.5_Frame_Shift_Del_p.K195fs			Q9HAZ2	PRD16_HUMAN	PR domain containing 16	195	SET.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			breast(4)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(7)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(3)	59	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		GATTTACTATAAAGTCATTAA	0.557			T	EVI1	"""MDS, AML"""								2	4	---	---	---	---					
TAF1B	9014	broad.mit.edu	37	2	9989571	9989571	+	Frame_Shift_Del	DEL	A	A	-			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr2:9989571delA	ENST00000263663.5	+	3	375	c.187delA	c.(187-189)aafs	p.K65fs	TAF1B_ENST00000402170.1_3'UTR|TAF1B_ENST00000396242.3_5'UTR	NM_005680.2	NP_005671.2	Q53T94	TAF1B_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	65					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	14	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CCGGGGGCTTAAAAAAAAAAA	0.333													4	8	---	---	---	---					
PODXL	5420	broad.mit.edu	37	7	131241030	131241035	+	In_Frame_Del	DEL	GGCGAC	GGCGAC	-	rs11277659		TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr7:131241030_131241035delGGCGAC	ENST00000541194.1	-	1	341_346	c.84_89delGTCGCC	c.(82-90)ccc>cc	p.PSP28del	PODXL_ENST00000537928.1_In_Frame_Del_p.PSP28del|PODXL_ENST00000378555.3_In_Frame_Del_p.PSP28del|PODXL_ENST00000322985.9_In_Frame_Del_p.PSP28del|PODXL_ENST00000465001.1_Intron	NM_001018111.2	NP_001018121.1	O00592	PODXL_HUMAN	podocalyxin-like	28					cell adhesion|epithelial tube formation|negative regulation of cell-cell adhesion|positive regulation of cell migration|positive regulation of cell-cell adhesion mediated by integrin|regulation of microvillus assembly	actin cytoskeleton|apical plasma membrane|centrosome|filopodium|integral to plasma membrane|lamellipodium|membrane raft|microvillus membrane|nucleolus|ruffle		p.P30_S31delPS(2)		NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	24	Melanoma(18;0.162)					ATTCTGGGAGggcgacggcgacggcg	0.748													2	4	---	---	---	---					
PNLIPRP2	5408	broad.mit.edu	37	10	118396277	118396277	+	RNA	DEL	G	G	-	rs148140777	by1000genomes	TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr10:118396277delG	ENST00000537242.1	+	0	962				PNLIPRP2_ENST00000433618.4_RNA|PNLIPRP2_ENST00000298771.7_RNA	NM_005396.4	NP_005387.2	P54317	LIPR2_HUMAN	pancreatic lipase-related protein 2						galactolipid catabolic process|lipid digestion|phospholipid catabolic process|triglyceride metabolic process	extracellular space	acylglycerol lipase activity|calcium ion binding|galactolipase activity|phospholipase activity|triglyceride lipase activity			endometrium(1)|large_intestine(1)|lung(11)|prostate(3)	16				all cancers(201;0.015)		GACAAATTATGGTTTTTTTTT	0.423													3	4	---	---	---	---					
LOC102723841	102723841	broad.mit.edu	37	16	33365420	33365420	+	RNA	DEL	A	A	-			TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr16:33365420delA	ENST00000568520.1	-	0	249																											TACAAACTATAAAAAAACAGA	0.358													3	6	---	---	---	---					
FRG1B	284802	broad.mit.edu	37	20	29628226	29628226	+	Splice_Site	DEL	G	G	-	rs78710112	by1000genomes	TCGA-EB-A4OY-01A-11D-A25O-08	TCGA-EB-A4OY-10A-01D-A25O-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	F787897A-2061-4022-A72D-6264896E6D62	625EE15D-0BAE-44E7-8F70-669DA183CEAA	g.chr20:29628226delG	ENST00000278882.3	+	6	608		c.e6-1		FRG1B_ENST00000358464.4_Splice_Site|FRG1B_ENST00000439954.2_Splice_Site																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GTTTCACTTAGGGGAAAATGG	0.358													7	127	---	---	---	---					
