Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ADARB2	105	broad.mit.edu	37	10	1284223	1284223	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:1284223G>A	ENST00000381312.1	-	5	1657	c.1332C>T	c.(1330-1332)ttC>ttT	p.F444F		NM_018702.3	NP_061172.1	Q9NS39	RED2_HUMAN	adenosine deaminase, RNA-specific, B2 (non-functional)	444	A to I editase.				mRNA processing	mitochondrion|nucleus	adenosine deaminase activity|double-stranded RNA binding|metal ion binding|single-stranded RNA binding			breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(17)|prostate(2)|skin(1)|urinary_tract(1)	41		all_epithelial(10;0.059)|Colorectal(49;0.0815)		all cancers(11;0.0224)|GBM - Glioblastoma multiforme(2;0.0414)|Epithelial(11;0.165)		GCGTGTAGAGGAAGTGCAGGA	0.706000													3	14					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179616292	179616292	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:179616292C>T	ENST00000360870.5	-	46	11057	c.10835G>A	c.(10834-10836)aGa>aAa	p.R3612K	TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9474							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCGTTCTGCTCTTTTCAGAAA	0.383000													41	44					0	0	1	0	0
OR8D1	283159	broad.mit.edu	37	11	124180299	124180299	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr11:124180299G>A	ENST00000357821.2	-	1	434	c.364C>T	c.(364-366)Cgc>Tgc	p.R122C		NM_001002917.1	NP_001002917.1	Q8WZ84	OR8D1_HUMAN	olfactory receptor, family 8, subfamily D, member 1	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)|large_intestine(1)|lung(7)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		GCAACATAGCGATCATATGCC	0.488000													10	12					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179529447	179529447	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:179529447C>T	ENST00000589042.1	-	167	36360	c.36136G>A	c.(36136-36138)Gaa>Aaa	p.E12046K	TTN-AS1_ENST00000431752.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000592630.1_RNA|TTN_ENST00000591111.1_Intron|TTN-AS1_ENST00000589830.1_RNA|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	10194	Ig-like 80.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGGACAATTTCTTGGAGAGCT	0.393000													12	14					0	0	1	0	0
SLC1A5	6510	broad.mit.edu	37	19	47278789	47278789	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:47278789G>A	ENST00000542575.2	-	8	2232	c.1604C>T	c.(1603-1605)tCt>tTt	p.S535F	SLC1A5_ENST00000434726.2_Missense_Mutation_p.S333F|SLC1A5_ENST00000594991.1_Missense_Mutation_p.S359F|FKRP_ENST00000600646.1_Intron|SLC1A5_ENST00000412532.2_Missense_Mutation_p.S307F	NM_005628.2	NP_005619.1	Q15758	AAAT_HUMAN	solute carrier family 1 (neutral amino acid transporter), member 5	535					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(2)|stomach(1)	13		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	TTCCTTCTCAGAGGCGACCGT	0.587000													91	87					0	0	1	0	0
HIVEP3	59269	broad.mit.edu	37	1	42047337	42047337	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:42047337G>A	ENST00000372584.1	-	3	4146	c.3132C>T	c.(3130-3132)ttC>ttT	p.F1044F	HIVEP3_ENST00000247584.5_Silent_p.F1044F|HIVEP3_ENST00000372583.1_Silent_p.F1044F|HIVEP3_ENST00000429157.2_Silent_p.F1044F	NM_001127714.2	NP_001121186.1	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer binding protein 3	1044	No DNA binding activity or transactivation activity, but complete prevention of TRAF-dependent NF-Kappa-B activation; associates with TRAF2 and JUN (By similarity).				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			NS(2)|breast(3)|central_nervous_system(5)|endometrium(13)|kidney(3)|large_intestine(13)|lung(33)|ovary(4)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	85	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				GTCTCACCAAGAAGCATTTTC	0.582000													23	28					0	0	1	0	0
ANKRD24	170961	broad.mit.edu	37	19	4219633	4219633	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:4219633G>A	ENST00000600132.1	+	19	3325	c.3049G>A	c.(3049-3051)Gag>Aag	p.E1017K	ANKRD24_ENST00000318934.4_Missense_Mutation_p.E1017K|ANKRD24_ENST00000262970.5_Missense_Mutation_p.E1107K	NM_133475.1	NP_597732.1	Q8TF21	ANR24_HUMAN	ankyrin repeat domain 24	1017										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		ACACGCAGCCGAGGCACAGCT	0.642000													59	82					0	0	1	0	0
SLC45A3	85414	broad.mit.edu	37	1	205628503	205628503	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:205628503G>A	ENST00000367145.3	-	5	1816	c.1521C>T	c.(1519-1521)tcC>tcT	p.S507S	SLC45A3_ENST00000460934.1_5'UTR	NM_033102.2	NP_149093.1	Q96JT2	S45A3_HUMAN	solute carrier family 45, member 3	507					transmembrane transport	integral to membrane			SLC45A3/BRAF(2)|SLC45A3/ELK4(18)|SLC45A3/ETV1(3)|SLC45A3/ETV5_ENST00000306376(2)|SLC45A3/ERG(50)	cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(7)|ovary(3)|prostate(5)	21	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0194)			CCATAAACAGGGATGGGGCCA	0.622000			T	"""ETV1, ETV5, ELK4, ERG"""	prostate						OREG0014161	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	43					0	0	1	0	0
DLC1	10395	broad.mit.edu	37	8	12957624	12957624	+	Missense_Mutation	SNP	C	C	G			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr8:12957624C>G	ENST00000276297.4	-	9	2631	c.2222G>C	c.(2221-2223)aGc>aCc	p.S741T	DLC1_ENST00000520226.1_Missense_Mutation_p.S230T|DLC1_ENST00000358919.2_Missense_Mutation_p.S304T|DLC1_ENST00000512044.2_Missense_Mutation_p.S338T	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	741	Poly-Ser.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						GCTGCTGCTGCTGGTCTGCGT	0.627000													3	54					0	0	1	0	0
WFDC8	90199	broad.mit.edu	37	20	44181842	44181842	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr20:44181842G>A	ENST00000357199.4	-	5	597	c.519C>T	c.(517-519)atC>atT	p.I173I	WFDC8_ENST00000289953.2_Silent_p.I173I	NM_181510.2	NP_852611.2	Q8IUA0	WFDC8_HUMAN	WAP four-disulfide core domain 8	173	WAP 2.					extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(4)|stomach(1)|upper_aerodigestive_tract(1)	15		Myeloproliferative disorder(115;0.0122)				GGGGACAATCGATGTCACTGT	0.463000													43	40					0	0	1	0	0
ANKRD16	54522	broad.mit.edu	37	10	5920177	5920177	+	Silent	SNP	A	A	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:5920177A>T	ENST00000380094.5	-	7	1545	c.1002T>A	c.(1000-1002)tcT>tcA	p.S334S	ANKRD16_ENST00000380092.4_Silent_p.S334S|ANKRD16_ENST00000191063.8_3'UTR	NM_019046.2	NP_061919.1	Q6P6B7	ANR16_HUMAN	ankyrin repeat domain 16	334										breast(1)|endometrium(1)|large_intestine(5)|lung(3)|stomach(2)	12						TGATGTCTTCAGAATCCTTCA	0.557000													42	74					0	0	1	0	0
KRTAP4-11	653240	broad.mit.edu	37	17	39274087	39274087	+	Missense_Mutation	SNP	G	G	C	rs141357429	by1000genomes	TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr17:39274087G>C	ENST00000391413.2	-	1	519	c.481C>G	c.(481-483)Ctg>Gtg	p.L161V		NM_033059.3	NP_149048.2	Q9BYQ6	KR411_HUMAN	keratin associated protein 4-11	161	27 X 5 AA repeats of C-C-[GIKRQVHEL]- [SPTR]-[STVQRMC].					keratin filament		p.L161V(1)		endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|lung(8)|prostate(5)|skin(1)	33		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			ACTGGACGCAGGcagcagcag	0.657000													4	12					0	0	1	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99621867	99621867	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:99621867C>T	ENST00000324306.6	+	3	751	c.517C>T	c.(517-519)Cac>Tac	p.H173Y	ZKSCAN1_ENST00000535170.1_Intron|ZKSCAN1_ENST00000426572.1_Missense_Mutation_p.H137Y	NM_003439.1	NP_003430.1	P17029	ZKSC1_HUMAN	zinc finger with KRAB and SCAN domains 1	173					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			TGACCTTCATCACGAGGCCAC	0.532000													31	49					0	0	1	0	0
AXDND1	126859	broad.mit.edu	37	1	179338084	179338084	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:179338084C>T	ENST00000367618.3	+	3	634	c.247C>T	c.(247-249)Cct>Tct	p.P83S	AXDND1_ENST00000457238.2_Missense_Mutation_p.P83S|AXDND1_ENST00000461179.2_Intron	NM_144696.4	NP_653297.3	Q5T1B0	AXDN1_HUMAN	axonemal dynein light chain domain containing 1	83										NS(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(27)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	59						CTTACTACCTCCTAAGAAAAT	0.373000													27	28					0	0	1	0	0
NUP210L	91181	broad.mit.edu	37	1	154112302	154112302	+	Silent	SNP	A	A	G			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:154112302A>G	ENST00000368559.3	-	5	764	c.693T>C	c.(691-693)gtT>gtC	p.V231V	NUP210L_ENST00000271854.3_Silent_p.V231V	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	231						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			CATGAATTCGAACTTTTACAA	0.363000													159	156					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175372639	175372639	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:175372639G>A	ENST00000367674.1	-	4	1321	c.613C>T	c.(613-615)Ccg>Tcg	p.P205S	TNR_ENST00000263525.2_Missense_Mutation_p.P205S	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	205	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					CAACCCAGCGGGCAGTAGGGC	0.592000													136	170					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80042406	80042406	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr17:80042406G>A	ENST00000306749.2	-	27	4969	c.4751C>T	c.(4750-4752)tCc>tTc	p.S1584F		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	1584					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	GGCATCAGGGGACAGCTTGCC	0.682000													10	1					0	0	1	0	0
PCLO	27445	broad.mit.edu	37	7	82763921	82763921	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:82763921G>A	ENST00000423517.2	-	3	3282	c.2945C>T	c.(2944-2946)tCc>tTc	p.S982F	PCLO_ENST00000333891.8_Missense_Mutation_p.S982F	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	928					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTGACCTGTGGATTTGGGTGG	0.522000													14	11					0	0	1	0	0
ACVRL1	94	broad.mit.edu	37	12	52309829	52309829	+	Missense_Mutation	SNP	T	T	G			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:52309829T>G	ENST00000550683.1	+	7	1201	c.1100T>G	c.(1099-1101)gTg>gGg	p.V367G	ACVRL1_ENST00000388922.4_Missense_Mutation_p.V353G|ACVRL1_ENST00000419526.2_Missense_Mutation_p.V179G	NM_001077401.1	NP_001070869.1	P37023	ACVL1_HUMAN	activin A receptor type II-like 1	353	Protein kinase.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|blood vessel maturation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of endothelial cell migration|negative regulation of focal adhesion assembly|positive regulation of BMP signaling pathway|positive regulation of transcription, DNA-dependent|regulation of blood pressure|regulation of blood vessel endothelial cell migration|regulation of DNA replication|regulation of endothelial cell proliferation|transforming growth factor beta receptor signaling pathway|wound healing, spreading of epidermal cells	cell surface|integral to plasma membrane	activin binding|activin receptor activity, type I|ATP binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	20				BRCA - Breast invasive adenocarcinoma(357;0.0991)	Adenosine triphosphate(DB00171)	GGCCTGGCTGTGATGCACTCA	0.632000													68	66					0	0	1	0	0
MSLNL	401827	broad.mit.edu	37	16	823261	823261	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr16:823261G>A	ENST00000293892.3	-	10	2006	c.2007C>T	c.(2005-2007)ttC>ttT	p.F669F	MSLNL_ENST00000442466.1_Silent_p.F318F			Q96KJ4	MSLNL_HUMAN	mesothelin-like	318					cell adhesion	integral to membrane				breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(15)|ovary(2)|pancreas(2)|prostate(4)|skin(1)|urinary_tract(2)	36						AGTGCACCAGGAAGAGGTCGT	0.647000													44	57					0	0	1	0	0
SYF2	25949	broad.mit.edu	37	1	25555608	25555608	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:25555608C>T	ENST00000236273.4	-	3	164	c.139G>A	c.(139-141)Gct>Act	p.A47T	SYF2_ENST00000354361.3_Intron	NM_015484.4	NP_056299.1	O95926	SYF2_HUMAN	SYF2 pre-mRNA-splicing factor	47						catalytic step 2 spliceosome				kidney(1)|large_intestine(1)|lung(4)	6		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.5e-26)|Colorectal(126;2.54e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000455)|STAD - Stomach adenocarcinoma(196;0.000766)|KIRC - Kidney renal clear cell carcinoma(1967;0.00145)|GBM - Glioblastoma multiforme(114;0.00443)|READ - Rectum adenocarcinoma(331;0.0936)|Lung(427;0.201)		AATTTACGAGCTTCATTCTAA	0.383000													29	39					0	0	1	0	0
VPS26A	9559	broad.mit.edu	37	10	70916829	70916829	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:70916829G>A	ENST00000373382.1	+	5	949	c.296G>A	c.(295-297)gGa>gAa	p.G99E	VPS26A_ENST00000546041.1_Missense_Mutation_p.G82E|VPS26A_ENST00000395098.1_Missense_Mutation_p.G99E|VPS26A_ENST00000489794.1_Missense_Mutation_p.G74E|VPS26A_ENST00000263559.6_Missense_Mutation_p.G99E|VPS26A_ENST00000490696.1_3'UTR|VPS26A_ENST00000541711.1_5'UTR			O75436	VP26A_HUMAN	vacuolar protein sorting 26 homolog A (S. pombe)	99					retrograde transport, endosome to Golgi|vacuolar transport	cytosol|endosome membrane|retromer complex|vesicle	protein binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(2)	8						GCCTTACCTGGAGAACTGACT	0.348000													11	38					0	0	1	0	0
LRSAM1	90678	broad.mit.edu	37	9	130230109	130230109	+	Splice_Site	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr9:130230109G>A	ENST00000323301.4	+	9	1223	c.619_splice	c.e9+1	p.E207_splice	LRSAM1_ENST00000373322.1_Splice_Site_p.E207_splice|LRSAM1_ENST00000373324.4_Splice_Site_p.E207_splice|LRSAM1_ENST00000300417.6_Splice_Site_p.E207_splice	NM_138361.5	NP_612370.3	Q6UWE0	LRSM1_HUMAN	leucine rich repeat and sterile alpha motif containing 1	207					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(2)	16						CCTCTGCAAAGGTAAAGCCAG	0.632000													5	12					0	0	1	0	0
RHO	6010	broad.mit.edu	37	3	129251489	129251489	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:129251489C>T	ENST00000296271.3	+	4	904	c.810C>T	c.(808-810)agC>agT	p.S270S		NM_000539.3	NP_000530.1	P08100	OPSD_HUMAN	rhodopsin	270					protein-chromophore linkage|rhodopsin mediated signaling pathway	Golgi apparatus|integral to plasma membrane|photoreceptor inner segment membrane|photoreceptor outer segment membrane	G-protein coupled receptor activity|metal ion binding|photoreceptor activity|protein binding			breast(1)|endometrium(1)|large_intestine(10)|lung(6)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	22		all_neural(597;0.0227)|Myeloproliferative disorder(1037;0.0255)|Prostate(884;0.183)		GBM - Glioblastoma multiforme(114;2.58e-05)|Lung(219;0.0234)	Halothane(DB01159)	CCTACGCCAGCGTGGCATTCT	0.572000													27	28					0	0	1	0	0
ADAD1	132612	broad.mit.edu	37	4	123333824	123333824	+	Missense_Mutation	SNP	T	T	C			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr4:123333824T>C	ENST00000296513.2	+	10	1294	c.1109T>C	c.(1108-1110)gTt>gCt	p.V370A	ADAD1_ENST00000388725.2_Missense_Mutation_p.V352A|ADAD1_ENST00000388724.2_Missense_Mutation_p.V359A	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	370	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding	p.V370A(1)		breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						TATCTGACTGTTTACTGTCCT	0.408000													68	63					0	0	1	0	0
DNAH7	56171	broad.mit.edu	37	2	196759756	196759756	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:196759756C>T	ENST00000312428.6	-	30	4940	c.4840G>A	c.(4840-4842)Gga>Aga	p.G1614R		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1614	AAA 2 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity	p.G1614R(1)		NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CTAGTTTTTCCTCCAAATGGT	0.318000													20	14					0	0	1	0	0
IGSF21	84966	broad.mit.edu	37	1	18688694	18688694	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:18688694C>T	ENST00000251296.1	+	5	893	c.510C>T	c.(508-510)tgC>tgT	p.C170C		NM_032880.4	NP_116269.3	Q96ID5	IGS21_HUMAN	immunoglobin superfamily, member 21	170						extracellular region				endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	40		Colorectal(325;0.000147)|Renal(390;0.00145)|all_lung(284;0.00366)|Lung NSC(340;0.00376)|Breast(348;0.00387)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0439)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0121)|BRCA - Breast invasive adenocarcinoma(304;5.52e-05)|Kidney(64;0.00103)|KIRC - Kidney renal clear cell carcinoma(64;0.0102)|STAD - Stomach adenocarcinoma(196;0.0118)|READ - Rectum adenocarcinoma(331;0.157)		CGCTGGTCTGCATCGTGTCTG	0.612000													14	19					0	0	1	0	0
LMO3	55885	broad.mit.edu	37	12	16753612	16753612	+	Silent	SNP	G	G	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:16753612G>T	ENST00000320122.6	-	2	705	c.183C>A	c.(181-183)atC>atA	p.I61I	LMO3_ENST00000541846.1_Silent_p.I61I|LMO3_ENST00000441439.2_Silent_p.I61I|LMO3_ENST00000537304.1_Silent_p.I61I|LMO3_ENST00000541295.1_Silent_p.I79I|LMO3_ENST00000447609.1_Silent_p.I61I|LMO3_ENST00000535535.1_Silent_p.I61I|LMO3_ENST00000354662.1_Silent_p.I61I|LMO3_ENST00000540848.1_Silent_p.I61I|LMO3_ENST00000534946.1_Silent_p.I61I|LMO3_ENST00000540445.1_Intron|LMO3_ENST00000261169.6_Silent_p.I72I|LMO3_ENST00000537568.1_Intron	NM_001243611.1	NP_001230540.1	Q8TAP4	LMO3_HUMAN	LIM domain only 3 (rhombotin-like 2)	61	LIM zinc-binding 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent		zinc ion binding			endometrium(2)|large_intestine(2)|skin(1)	5		Hepatocellular(102;0.244)				TGCGACAAAGGATAAGATTAG	0.448000													24	34					1.55469e-16	1.56641e-16	1	1	0
NRAS	4893	broad.mit.edu	37	1	115256529	115256529	+	Missense_Mutation	SNP	T	T	C	rs11554290		TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:115256529T>C	ENST00000369535.4	-	3	435	c.182A>G	c.(181-183)cAa>cGa	p.Q61R		NM_002524.4	NP_002515.1	P01111	RASN_HUMAN	neuroblastoma RAS viral (v-ras) oncogene homolog	61			Q -> K (in neuroblastoma cell).|Q -> R (in lung carcinoma cell and melanoma; dbSNP:rs11554290).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	Golgi membrane|plasma membrane	GTP binding|GTPase activity	p.Q61R(817)|p.Q61L(175)|p.Q61P(23)|p.Q61K(1)		NS(134)|adrenal_gland(9)|autonomic_ganglia(9)|biliary_tract(6)|bone(1)|breast(9)|central_nervous_system(10)|cervix(2)|endometrium(11)|eye(3)|haematopoietic_and_lymphoid_tissue(1115)|kidney(3)|large_intestine(105)|liver(10)|lung(42)|meninges(2)|ovary(7)|pancreas(5)|prostate(8)|skin(1144)|soft_tissue(37)|stomach(5)|testis(8)|thyroid(359)|upper_aerodigestive_tract(28)|urinary_tract(13)	3085	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		GTACTCTTCTTGTCCAGCTGT	0.458000	Q61L(C3A_LIVER)|Q61L(HEPG2_LIVER)|Q61L(HL60_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(IPC298_SKIN)|Q61L(KMS21BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(MELJUSO_SKIN)|Q61L(MHHES1_BONE)|Q61L(MOLP8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61L(OCIAML3_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61P(TF1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(HT1197_URINARY_TRACT)|Q61R(KMS27_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|Q61R(KU1919_URINARY_TRACT)|Q61R(NCIH2347_LUNG)|Q61R(ONS76_CENTRAL_NERVOUS_SYSTEM)|Q61R(SKMEL2_SKIN)|Q61R(SW1271_LUNG)|Q61R(TT2609C02_THYROID)	50	Mis		"""melanoma, MM, AML, thyroid"""				Noonan syndrome	TSP Lung(23;0.16)|Multiple Myeloma(1;<1E-6)			132	108					0	0	1	0	0
C6	729	broad.mit.edu	37	5	41176815	41176815	+	Silent	SNP	A	A	G			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:41176815A>G	ENST00000263413.3	-	8	1194	c.930T>C	c.(928-930)gaT>gaC	p.D310D	C6_ENST00000475349.1_5'UTR|C6_ENST00000337836.5_Silent_p.D310D	NM_001115131.1	NP_001108603.2	P13671	CO6_HUMAN	complement component 6	310	MACPF.				complement activation, classical pathway|cytolysis|innate immune response	membrane attack complex	protein binding			central_nervous_system(2)|cervix(2)|endometrium(2)|kidney(7)|large_intestine(16)|liver(1)|lung(51)|ovary(3)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)	96		Breast(839;1.07e-05)|Ovarian(839;0.0228)|Lung SC(612;0.0548)|Lung NSC(810;0.128)|all_neural(839;0.157)				TAAAACTAGAATCCTAAATGG	0.308000													8	8					0	0	1	0	0
SHPRH	257218	broad.mit.edu	37	6	146271487	146271487	+	Missense_Mutation	SNP	C	C	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr6:146271487C>A	ENST00000367503.3	-	4	1293	c.895G>T	c.(895-897)Gca>Tca	p.A299S	SHPRH_ENST00000367505.2_Missense_Mutation_p.A299S|SHPRH_ENST00000275233.7_Missense_Mutation_p.A299S|SHPRH_ENST00000438092.2_Missense_Mutation_p.A299S	NM_001042683.2	NP_001036148.2	Q149N8	SHPRH_HUMAN	SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase	299					DNA repair|nucleosome assembly	nucleosome|nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(33)|ovary(3)|pancreas(2)|prostate(7)|skin(1)|urinary_tract(1)	79		Ovarian(120;0.0365)		OV - Ovarian serous cystadenocarcinoma(155;1.47e-07)|GBM - Glioblastoma multiforme(68;0.0124)		GGGATCAATGCAGGATGCTGG	0.463000													53	72					1.14385e-22	1.1583e-22	1	1	0
HRC	3270	broad.mit.edu	37	19	49656898	49656898	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:49656898C>T	ENST00000252825.4	-	1	1783	c.1597G>A	c.(1597-1599)Gag>Aag	p.E533K	HRC_ENST00000595625.1_Missense_Mutation_p.E533K	NM_002152.2	NP_002143.1	P23327	SRCH_HUMAN	histidine rich calcium binding protein	533					muscle contraction	sarcoplasmic reticulum lumen	calcium ion binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(10)|lung(10)|ovary(1)|prostate(3)|urinary_tract(2)	34		all_lung(116;3.16e-06)|Lung NSC(112;6.25e-06)|all_neural(266;0.0189)|Ovarian(192;0.0392)		all cancers(93;2.01e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.00019)|GBM - Glioblastoma multiforme(486;0.00279)|Epithelial(262;0.00622)		tcttcctcctcctGGTTCAGG	0.587000													12	14					0	0	1	0	0
ANXA3	306	broad.mit.edu	37	4	79525461	79525461	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr4:79525461C>T	ENST00000264908.6	+	12	1199	c.820C>T	c.(820-822)Cga>Tga	p.R274*	ANXA3_ENST00000503570.2_Nonsense_Mutation_p.R235*|ANXA3_ENST00000512884.1_Nonsense_Mutation_p.R235*	NM_005139.2	NP_005130.1	P12429	ANXA3_HUMAN	annexin A3	274					defense response to bacterium|neutrophil degranulation|phagocytosis|positive regulation of angiogenesis|positive regulation of endothelial cell migration|positive regulation of sequence-specific DNA binding transcription factor activity	phagocytic vesicle membrane|plasma membrane|specific granule	calcium ion binding|calcium-dependent phospholipid binding|phospholipase A2 inhibitor activity			NS(1)|breast(1)|kidney(1)|large_intestine(1)|lung(7)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						TACTCTGAACCGAATAATGGT	0.368000													44	31					0	0	1	0	0
OR9I1	219954	broad.mit.edu	37	11	57886005	57886005	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr11:57886005G>A	ENST00000302610.1	-	1	911	c.912C>T	c.(910-912)gtC>gtT	p.V304V	OR9Q1_ENST00000335397.3_Intron	NM_001005211.1	NP_001005211.1	Q8NGQ6	OR9I1_HUMAN	olfactory receptor, family 9, subfamily I, member 1	304					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V304V(1)		endometrium(2)|large_intestine(2)|liver(1)|lung(15)|pancreas(1)|skin(1)|urinary_tract(1)	23		Breast(21;0.0589)				GTCTCCTAGCGACCTTTCTGA	0.428000													41	24					0	0	1	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656659	40656659	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:40656659C>T	ENST00000406785.1	-	2	951	c.762G>A	c.(760-762)agG>agA	p.R254R	SLC8A1_ENST00000405269.1_Silent_p.R254R|SLC8A1_ENST00000332839.4_Silent_p.R254R|SLC8A1_ENST00000403092.1_Silent_p.R254R|SLC8A1_ENST00000542024.1_Silent_p.R254R|SLC8A1_ENST00000402441.1_Silent_p.R254R|SLC8A1_ENST00000408028.2_Silent_p.R254R|SLC8A1_ENST00000542756.1_Silent_p.R254R|SLC8A1_ENST00000406391.2_Silent_p.R254R|SLC8A1_ENST00000405901.3_Silent_p.R254R			P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 1	254	Calmodulin-binding (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			NS(1)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|liver(1)|lung(57)|ovary(2)|pancreas(1)|skin(7)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(2)	100					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	ACAGAAGTCTCCTATCCGCTA	0.453000													49	49					0	0	1	0	0
SELE	6401	broad.mit.edu	37	1	169699572	169699572	+	Splice_Site	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:169699572C>T	ENST00000333360.7	-	5	855		c.e5+1		SELE_ENST00000367776.1_Splice_Site|SELE_ENST00000367777.1_Splice_Site|SELE_ENST00000367775.1_Intron|SELE_ENST00000367782.4_Splice_Site|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367781.4_Splice_Site|SELE_ENST00000367780.4_Intron|SELE_ENST00000367779.4_Splice_Site|SELE_ENST00000367774.1_Splice_Site	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E						actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					GAGGGATTTACCATTGCAGGC	0.438000													34	68					0	0	1	0	0
OTOGL	283310	broad.mit.edu	37	12	80647328	80647328	+	Silent	SNP	A	A	C			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:80647328A>C	ENST00000458043.2	+	13	1347	c.1341A>C	c.(1339-1341)tcA>tcC	p.S447S	OTOGL_ENST00000547103.1_Silent_p.S447S	NM_173591.3	NP_775862.3			otogelin-like											breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(14)|prostate(1)	23						CAGTTGGTTCAAAAATTGAAC	0.388000													24	29					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179432386	179432386	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:179432386C>T	ENST00000589042.1	-	326	78697	c.78473G>A	c.(78472-78474)aGa>aAa	p.R26158K	TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.R17218K|TTN_ENST00000342175.6_Missense_Mutation_p.R17285K|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.R24517K|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.R23590K|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.R17093K	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	24517	Fibronectin type-III 90.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GAATTCATATCTTTGATCTTC	0.408000													21	28					0	0	1	0	0
SIRT6	51548	broad.mit.edu	37	19	4179205	4179205	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:4179205G>A	ENST00000337491.2	-	3	337	c.273C>T	c.(271-273)ccC>ccT	p.P91P	SIRT6_ENST00000601488.1_Intron|SIRT6_ENST00000305232.6_Silent_p.P91P|SIRT6_ENST00000381935.3_Silent_p.P19P|SIRT6_ENST00000594279.1_Silent_p.P19P	NM_016539.2	NP_057623.2	Q8N6T7	SIRT6_HUMAN	sirtuin 6	91	Deacetylase sirtuin-type.				chromatin silencing|protein ADP-ribosylation	nuclear telomeric heterochromatin|nucleoplasm	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity|NAD+ binding|NAD-dependent histone deacetylase activity (H3-K9 specific)|protein binding|zinc ion binding			central_nervous_system(1)|kidney(1)|lung(4)|ovary(1)|skin(1)	8		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.023)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGTCTGCGTGGGCCGCGCGC	0.682000													9	14					0	0	1	0	0
REEP4	80346	broad.mit.edu	37	8	21997708	21997708	+	Silent	SNP	G	G	A	rs146312249		TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr8:21997708G>A	ENST00000306306.3	-	3	627	c.159C>T	c.(157-159)atC>atT	p.I53I	REEP4_ENST00000523293.1_Silent_p.I53I|REEP4_ENST00000334530.5_Silent_p.I53I	NM_025232.2	NP_079508.2	Q9H6H4	REEP4_HUMAN	receptor accessory protein 4	53						integral to membrane				kidney(1)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	7				Colorectal(74;0.00187)|COAD - Colon adenocarcinoma(73;0.061)|READ - Rectum adenocarcinoma(644;0.0993)		TGTCTGTAACGATCTCTGCTG	0.597000													6	90					0	0	1	0	0
ZNF831	128611	broad.mit.edu	37	20	57768441	57768441	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr20:57768441C>T	ENST00000371030.2	+	1	2367	c.2367C>T	c.(2365-2367)gcC>gcT	p.A789A		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	789						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					AAGGAGGTGCCCGAGGTGTGG	0.657000													17	19					0	0	1	0	0
CARM1	10498	broad.mit.edu	37	19	11031728	11031728	+	Missense_Mutation	SNP	A	A	C			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:11031728A>C	ENST00000327064.4	+	14	1730	c.1540A>C	c.(1540-1542)Atg>Ctg	p.M514L	CARM1_ENST00000344150.4_Missense_Mutation_p.M514L	NM_199141.1	NP_954592.1	Q86X55	CARM1_HUMAN	coactivator-associated arginine methyltransferase 1	514	Transactivation domain (By similarity).				cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	13						GGACACAGGGATGCCGACCGC	0.667000													20	34					0	0	1	0	0
IGHG1	3500	broad.mit.edu	37	14	106204163	106204163	+	RNA	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr14:106204163G>A	ENST00000390548.2	-	0	1135																											GTCCACCACCGAGGAGAAGAT	0.667000													73	111					0	0	1	0	0
ARMC9	80210	broad.mit.edu	37	2	232100035	232100035	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:232100035C>T	ENST00000349938.4	+	8	915	c.721C>T	c.(721-723)Ctc>Ttc	p.L241F	ARMC9_ENST00000483477.1_3'UTR	NM_001271466.1|NM_025139.3	NP_001258395.1|NP_079415.3	Q7Z3E5	ARMC9_HUMAN	armadillo repeat containing 9	241							binding			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	22		Renal(207;0.0112)|all_lung(227;0.0744)|all_hematologic(139;0.0749)|Acute lymphoblastic leukemia(138;0.167)|Medulloblastoma(418;0.184)|Lung NSC(271;0.205)		Epithelial(121;1.43e-10)|LUSC - Lung squamous cell carcinoma(224;0.017)|Lung(119;0.0189)		CTACCACAATCTCATTGGAGT	0.488000													23	30					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58605024	58605024	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr14:58605024C>T	ENST00000267485.7	-	2	1247	c.1053G>A	c.(1051-1053)gaG>gaA	p.E351E	C14orf37_ENST00000334342.5_5'UTR	NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37	351						integral to membrane	binding	p.E351_G352>DC(1)		breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						CTTCCATACCCTCATGGCTTA	0.552000													66	107					0	0	1	0	0
BATF2	116071	broad.mit.edu	37	11	64757232	64757232	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr11:64757232G>A	ENST00000301887.4	-	3	324	c.194C>T	c.(193-195)tCc>tTc	p.S65F	BATF2_ENST00000435842.2_5'UTR|BATF2_ENST00000527716.1_Missense_Mutation_p.S41F	NM_138456.3	NP_612465.3	Q8N1L9	BATF2_HUMAN	basic leucine zipper transcription factor, ATF-like 2	65	Leucine-zipper.					nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(1)|ovary(1)|skin(1)	9						GGCCTGCAGGGACTGGATCTC	0.652000													11	28					0	0	1	0	0
IGF2BP1	10642	broad.mit.edu	37	17	47119686	47119686	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr17:47119686G>A	ENST00000290341.3	+	9	1358	c.1024G>A	c.(1024-1026)Gaa>Aaa	p.E342K	IGF2BP1_ENST00000431824.2_Missense_Mutation_p.E203K	NM_006546.3	NP_006537.3	Q9NZI8	IF2B1_HUMAN	insulin-like growth factor 2 mRNA binding protein 1	342	KH 2.|Necessary for interaction with ELAVL4 and binding to TAU mRNA (By similarity).				CRD-mediated mRNA stabilization|negative regulation of translation|regulation of mRNA stability involved in response to stress	CRD-mediated mRNA stability complex|cytosol|dendritic spine|lamellipodium|nucleus|plasma membrane|stress granule	mRNA 3'-UTR binding|mRNA 5'-UTR binding|nucleotide binding|protein binding|translation regulator activity	p.E342K(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	31						GGCCGAGCAGGAAATAATGAA	0.517000													58	1					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110401307	110401307	+	Splice_Site	SNP	G	G	C			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr8:110401307G>C	ENST00000378402.5	+	8	727		c.e8-1			NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1						immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTTTAATTAGATATGGTCTA	0.289000										HNSCC(38;0.096)			21	25					0	0	1	0	0
C5orf38	153571	broad.mit.edu	37	5	2752551	2752551	+	Missense_Mutation	SNP	G	G	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:2752551G>T	ENST00000515640.1	+	1	192	c.173G>T	c.(172-174)tGg>tTg	p.W58L	C5orf38_ENST00000397835.4_Missense_Mutation_p.W58L|C5orf38_ENST00000457752.2_Missense_Mutation_p.W58L|IRX2_ENST00000502957.1_Intron|C5orf38_ENST00000334000.3_Missense_Mutation_p.W58L|C5orf38_ENST00000505778.1_Missense_Mutation_p.W58L			Q86SI9	CEI_HUMAN	chromosome 5 open reading frame 38	58						extracellular region				endometrium(2)|large_intestine(1)|lung(1)	4				GBM - Glioblastoma multiforme(108;0.205)		GGGGCGCCTTGGTTGCGAATT	0.677000													6	11					3.59834e-05	3.61637e-05	1	1	0
TESPA1	9840	broad.mit.edu	37	12	55355009	55355009	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:55355009G>A	ENST00000524622.1	-	8	1757	c.1096C>T	c.(1096-1098)Ccc>Tcc	p.P366S	TESPA1_ENST00000531122.1_Missense_Mutation_p.P366S|TESPA1_ENST00000532804.1_Missense_Mutation_p.P366S|TESPA1_ENST00000449076.1_Missense_Mutation_p.P504S|TESPA1_ENST00000316577.8_Missense_Mutation_p.P504S	NM_001261844.1|NM_014796.2	NP_001248773.1|NP_055611.1	A2RU30	K0748_HUMAN	thymocyte expressed, positive selection associated 1	504																	GGTCTGCTGGGCCAGCGACTC	0.567000													113	122					0	0	1	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41442375	41442375	+	RNA	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:41442375G>A	ENST00000599198.1	+	0	467					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						TTCGGGATGGGAAAGCGGAGT	0.552000													16	18					0	0	1	0	0
TDO2	6999	broad.mit.edu	37	4	156825262	156825262	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr4:156825262G>A	ENST00000536354.2	+	2	192	c.128G>A	c.(127-129)gGg>gAg	p.G43E		NM_005651.3	NP_005642.1	P48775	T23O_HUMAN	tryptophan 2,3-dioxygenase	43	Substrate binding (By similarity).				tryptophan catabolic process to kynurenine	cytosol	tryptophan 2,3-dioxygenase activity			breast(3)|endometrium(1)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	18	all_hematologic(180;0.24)	Renal(120;0.0854)		KIRC - Kidney renal clear cell carcinoma(143;0.0455)|Kidney(143;0.0568)|COAD - Colon adenocarcinoma(41;0.141)	L-Tryptophan(DB00150)	CTTATCTATGGGAACTACCTG	0.413000													20	8					0	0	1	0	0
CCNG2	901	broad.mit.edu	37	4	78082696	78082696	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr4:78082696C>T	ENST00000316355.5	+	5	947	c.591C>T	c.(589-591)atC>atT	p.I197I	CCNG2_ENST00000395640.1_Silent_p.I197I|CCNG2_ENST00000354403.5_Silent_p.I197I|CCNG2_ENST00000497512.1_3'UTR|CCNG2_ENST00000509972.1_Silent_p.I197I|CCNG2_ENST00000502280.1_Silent_p.I197I	NM_004354.2	NP_004345.1	Q16589	CCNG2_HUMAN	cyclin G2	197					cell cycle checkpoint|cell division|mitosis	cytoplasm				breast(1)|kidney(2)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	10						GCCGACTCATCTTTTCAAAAG	0.294000													11	22					0	0	1	0	0
SLC16A11	162515	broad.mit.edu	37	17	6945575	6945575	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr17:6945575G>A	ENST00000308009.1	-	3	1263	c.926C>T	c.(925-927)cCg>cTg	p.P309L	SLC16A11_ENST00000447225.1_Missense_Mutation_p.P285L	NM_153357.1	NP_699188.1	Q8NCK7	MOT11_HUMAN	solute carrier family 16, member 11	309						integral to membrane|plasma membrane	symporter activity			endometrium(2)|kidney(2)|lung(2)|ovary(1)|skin(2)	9						CAGCAGCCGCGGGAGGGGCAC	0.741000													5	0					0	0	1	0	0
EEF1D	1936	broad.mit.edu	37	8	144672257	144672257	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr8:144672257G>A	ENST00000532741.1	-	1	373	c.145C>T	c.(145-147)Cgg>Tgg	p.R49W	EEF1D_ENST00000528610.1_Intron|EEF1D_ENST00000524624.1_Intron|EEF1D_ENST00000423316.2_Intron|EEF1D_ENST00000419152.2_Intron|EEF1D_ENST00000529272.1_Intron|EEF1D_ENST00000442189.2_Intron|EEF1D_ENST00000317198.6_Intron|EEF1D_ENST00000532400.1_Intron|EEF1D_ENST00000395119.3_Intron|EEF1D_ENST00000531621.1_Intron|EEF1D_ENST00000526838.1_Intron			P29692	EF1D_HUMAN	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	0					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytosol|eukaryotic translation elongation factor 1 complex	protein binding|signal transducer activity|translation elongation factor activity			breast(2)|cervix(1)|endometrium(1)|kidney(4)|lung(2)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.239)			CTCATCTTCCGGACACAGCGA	0.657000													35	39					0	0	1	0	0
TNFSF18	8995	broad.mit.edu	37	1	173010511	173010511	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:173010511G>A	ENST00000404377.3	-	3	596	c.596C>T	c.(595-597)tCc>tTc	p.S199F	RP1-15D23.2_ENST00000432694.1_RNA|TNFSF18_ENST00000239468.2_Missense_Mutation_p.S177F	NM_005092.3	NP_005083.2	Q9UNG2	TNF18_HUMAN	tumor necrosis factor (ligand) superfamily, member 18	199					anti-apoptosis|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding	p.S177F(1)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(3)|skin(1)	9						AAGTCTCTAGGAGATGAATTG	0.408000													13	19					0	0	1	0	0
FASLG	356	broad.mit.edu	37	1	172628636	172628636	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:172628636C>T	ENST00000367721.2	+	1	479	c.295C>T	c.(295-297)Ctg>Ttg	p.L99L	FASLG_ENST00000340030.3_Silent_p.L99L	NM_000639.1	NP_000630.1	P48023	TNFL6_HUMAN	Fas ligand (TNF superfamily, member 6)	99					activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of necroptosis by extracellular signals|induction of necroptosis of activated-T cells|necrotic cell death|negative regulation of angiogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane	cytokine activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(12)|prostate(1)|skin(1)	19						AGGATTGGGCCTGGGGATGTT	0.567000													11	18					0	0	1	0	0
FANCA	2175	broad.mit.edu	37	16	89809283	89809283	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr16:89809283C>T	ENST00000389301.3	-	37	3720	c.3690G>A	c.(3688-3690)ctG>ctA	p.L1230L	FANCA_ENST00000568369.1_Silent_p.L1230L	NM_000135.2	NP_000126.2	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A	1230					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			breast(5)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(16)|ovary(3)|skin(2)|urinary_tract(3)	47		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		TCGCAAAGTGCAGTGCAGCAG	0.537000			"""D, Mis, N, F, S"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia				57	63					0	0	1	0	0
RP1	6101	broad.mit.edu	37	8	55537910	55537910	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr8:55537910G>A	ENST00000220676.1	+	4	1616	c.1468G>A	c.(1468-1470)Gaa>Aaa	p.E490K		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	490					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TGAAGAAAGGGAAAGTGGGGA	0.358000													30	28					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48683676	48683676	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:48683676G>A	ENST00000544264.1	-	23	7605	c.7325C>T	c.(7324-7326)cCc>cTc	p.P2442L	CELSR3_ENST00000164024.4_Missense_Mutation_p.P2437L			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2437					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GTTCATGACGGGGTTCTGAGG	0.612000													21	35					0	0	1	0	0
GABRA3	2556	broad.mit.edu	37	X	151453191	151453191	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chrX:151453191C>T	ENST00000370314.4	-	4	517	c.279G>A	c.(277-279)gtG>gtA	p.V93V	GABRA3_ENST00000535043.1_Silent_p.V93V|GABRA3_ENST00000370311.1_Silent_p.V93V	NM_000808.3	NP_000799.1	P34903	GBRA3_HUMAN	gamma-aminobutyric acid (GABA) A receptor, alpha 3	93					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|skin(6)	37	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	TGTCAGTCTTCACTTCAGTCA	0.438000													32	3					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7578530	7578530	+	Missense_Mutation	SNP	A	A	G			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr17:7578530A>G	ENST00000420246.2	-	5	532	c.400T>C	c.(400-402)Ttt>Ctt	p.F134L	TP53_ENST00000445888.2_Missense_Mutation_p.F134L|TP53_ENST00000413465.2_Missense_Mutation_p.F134L|TP53_ENST00000455263.2_Missense_Mutation_p.F134L|TP53_ENST00000359597.4_Missense_Mutation_p.F134L|TP53_ENST00000269305.4_Missense_Mutation_p.F134L	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	134	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Required for interaction with FBXO42.		F -> C (in sporadic cancers; somatic mutation).|F -> I (in sporadic cancers; somatic mutation).|F -> L (in sporadic cancers; somatic mutation).|F -> S (in sporadic cancers; somatic mutation).|F -> V (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.F134L(16)|p.F134V(12)|p.0?(8)|p.C135fs*35(5)|p.M133fs*36(3)|p.N131fs*27(2)|p.V73fs*9(1)|p.F2V(1)|p.F41V(1)|p.S127fs*36(1)|p.?(1)|p.Y126fs*11(1)|p.F134fs*39(1)|p.K132_A138delKMFCQLA(1)|p.S127_Q136del10(1)|p.C135T(1)|p.F41L(1)|p.F2L(1)|p.M133fs*13(1)|p.M40fs*36(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGTTGGCAAAACATCTTGTTG	0.567000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			17	1					0	0	1	0	0
KCNN1	3780	broad.mit.edu	37	19	18092614	18092614	+	RNA	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:18092614C>T	ENST00000601725.1	+	0	230																											GTGCGCCATTCACCCGGTGCC	0.662000													19	19					0	0	1	0	0
ZNF826P	664701	broad.mit.edu	37	19	20607701	20607701	+	RNA	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:20607701G>A	ENST00000502675.1	-	0	61					NR_036455.1															large_intestine(4)	4						ACAGAGCAGTGAACAAGAGAT	0.577000													7	7					0	0	1	0	0
STRADB	55437	broad.mit.edu	37	2	202339374	202339374	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:202339374C>T	ENST00000194530.3	+	6	685	c.320C>T	c.(319-321)gCc>gTc	p.A107V	STRADB_ENST00000392249.2_Missense_Mutation_p.A107V	NM_001206864.1|NM_018571.5	NP_001193793.1|NP_061041.2	Q9C0K7	STRAB_HUMAN	STE20-related kinase adaptor beta	107	Protein kinase.				activation of protein kinase activity|cell cycle arrest|insulin receptor signaling pathway|protein export from nucleus|regulation of fatty acid oxidation	cytosol|nucleus	ATP binding|protein binding|protein kinase activity			breast(1)|large_intestine(2)|lung(5)|prostate(1)|skin(3)|stomach(1)	13						TCCTAGAAAGCCGTGATTCTA	0.408000													42	41					0	0	1	0	0
PLEK	5341	broad.mit.edu	37	2	68607989	68607989	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:68607989G>A	ENST00000234313.7	+	3	512	c.333G>A	c.(331-333)agG>agA	p.R111R		NM_002664.2	NP_002655.2	P08567	PLEK_HUMAN	pleckstrin	111					actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			autonomic_ganglia(1)|endometrium(3)|large_intestine(6)|lung(12)|ovary(1)|skin(1)	24		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		AATTTGCCAGGAAATCTACCA	0.463000													63	84					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29599814	29599814	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr13:29599814G>A	ENST00000431530.3	+	1	1067	c.1009G>A	c.(1009-1011)Gcc>Acc	p.A337T		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	327						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						GGGAAAGGCAGCCCAGGAAGG	0.542000													29	37					0	0	1	0	0
OSGEP	55644	broad.mit.edu	37	14	20915794	20915794	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr14:20915794C>T	ENST00000555656.1	-	5	2269	c.252G>A	c.(250-252)cgG>cgA	p.R84R	OSGEP_ENST00000206542.4_Silent_p.R283R|OSGEP_ENST00000554249.1_Silent_p.R101R			Q9NPF4	OSGEP_HUMAN	O-sialoglycoprotein endopeptidase	283					proteolysis|tRNA processing		metal ion binding|metalloendopeptidase activity|protein binding			endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(4)|stomach(1)	11	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0231)|READ - Rectum adenocarcinoma(17;0.196)		TAGCAAAAAGCCGGGCTCCAC	0.433000													27	17					0	0	1	0	0
FRMPD2	143162	broad.mit.edu	37	10	49448473	49448473	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:49448473C>T	ENST00000374201.3	-	6	932	c.630G>A	c.(628-630)agG>agA	p.R210R	FRMPD2_ENST00000407470.4_Silent_p.R179R|FRMPD2_ENST00000305531.3_Silent_p.R186R	NM_001018071.3	NP_001018081.3	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2	210					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			NS(2)|autonomic_ganglia(2)|breast(5)|cervix(1)|endometrium(3)|kidney(7)|large_intestine(15)|lung(24)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	66				Kidney(211;0.201)		GCAGCCTCTTCCTGAGCAGGT	0.587000													12	21					0	0	1	0	0
IL22RA1	58985	broad.mit.edu	37	1	24447897	24447897	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:24447897G>A	ENST00000270800.1	-	7	1161	c.1123C>T	c.(1123-1125)Cca>Tca	p.P375S		NM_021258.3	NP_067081.2	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1	375						integral to membrane	interferon receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		GCGTAGAATGGGAATTGAGCT	0.617000													92	76					0	0	1	0	0
PLCL2	23228	broad.mit.edu	37	3	17056374	17056374	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:17056374C>T	ENST00000418129.2	+	3	3076	c.2611C>T	c.(2611-2613)Ctg>Ttg	p.L871L	PLCL2_ENST00000396755.2_Silent_p.L871L|PLCL2_ENST00000432376.1_Silent_p.L871L	NM_001144382.1	NP_001137854.1	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2	997					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			breast(4)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(2)|skin(7)|urinary_tract(1)	43						GCCGGAGGTTCTGAAGAAGAT	0.502000													68	90					0	0	1	0	0
ARMCX2	9823	broad.mit.edu	37	X	100911365	100911365	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chrX:100911365G>A	ENST00000328766.5	-	5	1663	c.1210C>T	c.(1210-1212)Caa>Taa	p.Q404*	ARMCX2_ENST00000356824.4_Nonsense_Mutation_p.Q404*|ARMCX2_ENST00000330154.2_Nonsense_Mutation_p.Q404*	NM_014782.5	NP_055597.1	Q7L311	ARMX2_HUMAN	armadillo repeat containing, X-linked 2	404						integral to membrane	binding			NS(1)|breast(4)|endometrium(3)|kidney(1)|large_intestine(2)|lung(10)|ovary(6)|prostate(1)|skin(1)	29						GCTACCTGTTGGATGAAAGGA	0.453000													42	3					0	0	1	0	0
BRD2	6046	broad.mit.edu	37	6	32948438	32948438	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr6:32948438C>T	ENST00000395289.2	+	14	4055	c.2454C>T	c.(2452-2454)tcC>tcT	p.S818S	BRD2_ENST00000374831.4_Silent_p.S783S|BRD2_ENST00000443797.2_Silent_p.S663S|BRD2_ENST00000449085.2_Silent_p.S736S|BRD2_ENST00000395287.1_Silent_p.S818S|BRD2_ENST00000374825.4_Silent_p.S783S			P25440	BRD2_HUMAN	bromodomain containing 2	783					spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						GCTCAGATTCCAGCTCCTCCT	0.552000													38	45					0	0	1	0	0
SH2D5	400745	broad.mit.edu	37	1	21049315	21049315	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:21049315C>T	ENST00000375031.1	-	8	1374	c.750G>A	c.(748-750)gtG>gtA	p.V250V	SH2D5_ENST00000460804.1_5'UTR|SH2D5_ENST00000444387.2_Silent_p.V334V	NM_001103160.1	NP_001096630.1	Q6ZV89	SH2D5_HUMAN	SH2 domain containing 5	250	SH2.									lung(4)|prostate(1)|upper_aerodigestive_tract(1)	6		Colorectal(325;3.46e-05)|all_lung(284;5.32e-05)|Lung NSC(340;5.51e-05)|Renal(390;9.67e-05)|Breast(348;0.00179)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|COAD - Colon adenocarcinoma(152;1.17e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000142)|GBM - Glioblastoma multiforme(114;0.000465)|Kidney(64;0.000476)|STAD - Stomach adenocarcinoma(196;0.00303)|KIRC - Kidney renal clear cell carcinoma(64;0.00634)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		ACTGCGTGCGCACGGACAGAC	0.692000													3	7					0	0	1	0	0
BMP2	650	broad.mit.edu	37	20	6759103	6759103	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr20:6759103C>T	ENST00000378827.4	+	3	1777	c.558C>T	c.(556-558)ttC>ttT	p.F186F		NM_001200.2	NP_001191.1	P12643	BMP2_HUMAN	bone morphogenetic protein 2	186					BMP signaling pathway involved in heart induction|bone mineralization involved in bone maturation|cardiac cell differentiation|cardiac epithelial to mesenchymal transition|cartilage development|growth|negative regulation of cell cycle|negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|pathway-restricted SMAD protein phosphorylation|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cartilage development|positive regulation of endothelial cell proliferation|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of phosphatase activity|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	activin receptor activity, type II|BMP receptor binding|cytokine activity|growth factor activity|phosphatase activator activity|protein heterodimerization activity|SMAD binding|transforming growth factor beta receptor binding			breast(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)	13					Simvastatin(DB00641)	ACTCGAAATTCCCCGTGACCA	0.458000													30	34					0	0	1	0	0
PDE3A	5139	broad.mit.edu	37	12	20774298	20774298	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:20774298C>T	ENST00000359062.3	+	5	1533	c.1493C>T	c.(1492-1494)gCt>gTt	p.A498V	PDE3A_ENST00000544307.1_3'UTR	NM_000921.4|NM_001244683.1	NP_000912.3|NP_001231612.1	Q14432	PDE3A_HUMAN	phosphodiesterase 3A, cGMP-inhibited	498					lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(7)|lung(29)|ovary(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	58	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	TCATCCTATGCTATTTCTGCA	0.398000													18	21					0	0	1	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430789	37430789	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:37430789G>A	ENST00000374660.1	+	7	895	c.796G>A	c.(796-798)Gaa>Aaa	p.E266K	ANKRD30A_ENST00000602533.1_Missense_Mutation_p.E266K|ANKRD30A_ENST00000361713.1_Missense_Mutation_p.E266K			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	322						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						AAGCTTGGTGGAAAAAACACC	0.478000													12	34					0	0	1	0	0
SETD4	54093	broad.mit.edu	37	21	37417938	37417938	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr21:37417938G>A	ENST00000399215.1	-	5	2040	c.668C>T	c.(667-669)cCg>cTg	p.P223L	SETD4_ENST00000399201.1_Missense_Mutation_p.P199L|SETD4_ENST00000399207.1_Missense_Mutation_p.P223L|SETD4_ENST00000399212.1_Missense_Mutation_p.P199L|SETD4_ENST00000399208.2_Missense_Mutation_p.P223L|SETD4_ENST00000481477.1_5'UTR|SETD4_ENST00000332131.4_Missense_Mutation_p.P223L|SETD4_ENST00000399205.1_Missense_Mutation_p.P199L			Q9NVD3	SETD4_HUMAN	SET domain containing 4	223	SET.									autonomic_ganglia(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)	15						ACAGGTGTCCGGCTCTGCAGA	0.572000													41	44					0	0	1	0	0
GIT2	9815	broad.mit.edu	37	12	110370892	110370892	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:110370892G>A	ENST00000360185.4	-	19	2185	c.2021C>T	c.(2020-2022)tCa>tTa	p.S674L	GIT2_ENST00000551209.1_Missense_Mutation_p.S673L|GIT2_ENST00000553118.1_Missense_Mutation_p.S596L|GIT2_ENST00000361006.5_Missense_Mutation_p.S694L|GIT2_ENST00000354574.4_Missense_Mutation_p.S646L|GIT2_ENST00000355312.3_Missense_Mutation_p.S724L|GIT2_ENST00000356259.4_Missense_Mutation_p.S611L|GIT2_ENST00000457474.2_Missense_Mutation_p.S646L|GIT2_ENST00000338373.5_Missense_Mutation_p.S626L|GIT2_ENST00000343646.5_Missense_Mutation_p.S614L|TCHP_ENST00000550780.1_Intron			Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 2	724					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|skin(4)	27						GTCTGTGGGTGAGCCGGGGTc	0.577000													22	15					0	0	1	0	0
ITIH5	80760	broad.mit.edu	37	10	7679270	7679270	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:7679270G>A	ENST00000256861.6	-	5	651	c.573C>T	c.(571-573)atC>atT	p.I191I	ITIH5_ENST00000434980.1_5'UTR|ITIH5_ENST00000397145.2_Silent_p.I191I|ITIH5_ENST00000446830.2_5'UTR|ITIH5_ENST00000397146.2_Silent_p.I191I	NM_030569.6	NP_085046.5	Q86UX2	ITIH5_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 5	191					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity	p.I191I(2)		NS(1)|breast(3)|central_nervous_system(3)|endometrium(5)|kidney(6)|large_intestine(21)|lung(25)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|urinary_tract(3)	75						CGCTCTCCAGGATATTCACGT	0.652000													54	39					0	0	1	0	0
TENC1	23371	broad.mit.edu	37	12	53452406	53452406	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:53452406C>T	ENST00000314250.6	+	16	1566	c.1276C>T	c.(1276-1278)Ccc>Tcc	p.P426S	TENC1_ENST00000379902.3_Missense_Mutation_p.P302S|TENC1_ENST00000549700.1_Missense_Mutation_p.P426S|TENC1_ENST00000552570.1_Missense_Mutation_p.P426S|TENC1_ENST00000314276.3_Missense_Mutation_p.P436S|TENC1_ENST00000546602.1_Missense_Mutation_p.P426S|TENC1_ENST00000451358.1_Missense_Mutation_p.P426S	NM_170754.2	NP_736610.2	Q63HR2	TENC1_HUMAN	tensin like C1 domain containing phosphatase (tensin 2)	426					intracellular signal transduction|negative regulation of cell proliferation	focal adhesion	metal ion binding|phosphoprotein phosphatase activity|protein binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(2)|lung(19)|ovary(1)|pancreas(1)|stomach(3)	34						CTCCTCCAGCCCCGAGAAGAT	0.607000													27	25					0	0	1	0	0
IRGQ	126298	broad.mit.edu	37	19	44097263	44097263	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:44097263G>A	ENST00000422989.1	-	3	942	c.787C>T	c.(787-789)Ccc>Tcc	p.P263S	IRGQ_ENST00000602269.1_Missense_Mutation_p.P263S	NM_001007561.2	NP_001007562.1	Q8WZA9	IRGQ_HUMAN	immunity-related GTPase family, Q	263							protein binding			endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|pancreas(1)|prostate(3)	18		Prostate(69;0.0199)				GCTGGGAAGGGAGTGGGTGCT	0.692000													13	13					0	0	1	0	0
TIPIN	54962	broad.mit.edu	37	15	66641432	66641432	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr15:66641432G>A	ENST00000261881.4	-	6	526	c.441C>T	c.(439-441)ctC>ctT	p.L147L	TIPIN_ENST00000367709.4_Silent_p.L46L	NM_017858.2	NP_060328.2	Q9BVW5	TIPIN_HUMAN	TIMELESS interacting protein	147					cell division|DNA replication checkpoint|intra-S DNA damage checkpoint|mitosis|positive regulation of cell proliferation|regulation of DNA replication involved in S phase|replication fork protection	cytoplasm|nuclear chromatin	protein binding			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|ovary(1)|skin(1)|stomach(1)	7						GTAAAATAGGGAGATCAAGTC	0.303000													5	16					0	0	1	0	0
NDUFS1	4719	broad.mit.edu	37	2	206992629	206992629	+	Missense_Mutation	SNP	C	C	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:206992629C>A	ENST00000233190.5	-	16	2042	c.1776G>T	c.(1774-1776)aaG>aaT	p.K592N	NDUFS1_ENST00000440274.1_Missense_Mutation_p.K556N|NDUFS1_ENST00000432169.1_Missense_Mutation_p.K481N|NDUFS1_ENST00000423725.1_Missense_Mutation_p.K535N|NDUFS1_ENST00000457011.1_Missense_Mutation_p.K476N|NDUFS1_ENST00000455934.2_Missense_Mutation_p.K606N|NDUFS1_ENST00000449699.1_Missense_Mutation_p.K592N	NM_005006.6	NP_004997.4	P28331	NDUS1_HUMAN	NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)	592					apoptosis|ATP metabolic process|mitochondrial electron transport, NADH to ubiquinone|reactive oxygen species metabolic process|regulation of mitochondrial membrane potential|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	2 iron, 2 sulfur cluster binding|4 iron, 4 sulfur cluster binding|electron carrier activity|metal ion binding|NADH dehydrogenase (ubiquinone) activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(15)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38					NADH(DB00157)	ATGTAGCAGACTTCTCTGTGT	0.458000													3	56					0.115264	0.115552	1	1	0
GUCA1C	9626	broad.mit.edu	37	3	108635019	108635019	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:108635019C>T	ENST00000261047.3	-	3	529	c.397G>A	c.(397-399)Gaa>Aaa	p.E133K	GUCA1C_ENST00000393963.3_Missense_Mutation_p.E133K|GUCA1C_ENST00000471108.1_Missense_Mutation_p.E133K	NM_005459.3	NP_005450.3	O95843	GUC1C_HUMAN	guanylate cyclase activator 1C	133	EF-hand 4.				signal transduction|visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity			endometrium(2)|large_intestine(1)|liver(1)|lung(8)|pancreas(1)|skin(1)	14						TTGATGAATTCTTCAGGACTC	0.403000													59	68					0	0	1	0	0
RASSF9	9182	broad.mit.edu	37	12	86199302	86199302	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:86199302C>T	ENST00000361228.3	-	2	854	c.486G>A	c.(484-486)agG>agA	p.R162R		NM_005447.3	NP_005438.2	O75901	RASF9_HUMAN	Ras association (RalGDS/AF-6) domain family (N-terminal) member 9	162					endosome transport|protein targeting|signal transduction	cytosol|endosome|trans-Golgi network transport vesicle membrane	protein binding|transporter activity			endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GGAAAGTTTTCCTGACTATTC	0.388000													59	72					0	0	1	0	0
PCYOX1L	78991	broad.mit.edu	37	5	148742246	148742246	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:148742246C>T	ENST00000274569.4	+	2	197	c.135C>T	c.(133-135)ctC>ctT	p.L45L	PCYOX1L_ENST00000514349.1_5'UTR	NM_024028.3	NP_076933.3	Q8NBM8	PCYXL_HUMAN	prenylcysteine oxidase 1 like	45					prenylcysteine catabolic process	extracellular region	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor			breast(2)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCATTTTCTCCAGCAGCACT	0.587000													58	3					0	0	1	0	0
SMOC2	64094	broad.mit.edu	37	6	169053734	169053734	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr6:169053734G>A	ENST00000354536.5	+	11	1364	c.1144G>A	c.(1144-1146)Gaa>Aaa	p.E382K	SMOC2_ENST00000356284.2_Missense_Mutation_p.E371K	NM_022138.2	NP_071421.1	Q9H3U7	SMOC2_HUMAN	SPARC related modular calcium binding 2	371	EF-hand 1.				signal transduction	basement membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	32		Breast(66;0.000141)|Esophageal squamous(34;0.222)|Ovarian(120;0.231)		OV - Ovarian serous cystadenocarcinoma(33;1.31e-19)|BRCA - Breast invasive adenocarcinoma(81;3.06e-06)|GBM - Glioblastoma multiforme(31;0.00109)		CGGCAAAAAGGAAATCAAACC	0.443000													42	44					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179458554	179458554	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:179458554C>T	ENST00000589042.1	-	298	58697	c.58473G>A	c.(58471-58473)gaG>gaA	p.E19491E	TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Silent_p.E10551E|TTN_ENST00000342175.6_Silent_p.E10618E|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Silent_p.E17850E|TTN-AS1_ENST00000590807.1_RNA|TTN_ENST00000342992.6_Silent_p.E16923E|TTN-AS1_ENST00000589907.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN_ENST00000460472.2_Silent_p.E10426E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	17850	Fibronectin type-III 41.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTTGGTCACCTCATCAAAAC	0.388000													7	4					0	0	1	0	0
LSR	51599	broad.mit.edu	37	19	35749931	35749931	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:35749931G>A	ENST00000602122.1	+	3	1169	c.682G>A	c.(682-684)Ggg>Agg	p.G228R	LSR_ENST00000361790.3_Missense_Mutation_p.G228R|LSR_ENST00000597933.1_3'UTR|LSR_ENST00000427250.1_Intron|LSR_ENST00000360798.3_Missense_Mutation_p.G228R|LSR_ENST00000354900.3_Missense_Mutation_p.G228R|LSR_ENST00000347609.4_Missense_Mutation_p.G191R			Q86X29	LSR_HUMAN	lipolysis stimulated lipoprotein receptor	228	Ig-like V-type.				embryo development|liver development	chylomicron|integral to membrane|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle	receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	13	all_lung(56;3.91e-09)|Lung NSC(56;5.64e-09)|Esophageal squamous(110;0.162)		Epithelial(14;1.33e-19)|OV - Ovarian serous cystadenocarcinoma(14;1.29e-18)|all cancers(14;7.11e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			GGACCTCCAGGGGAACAATGA	0.592000													30	56					0	0	1	0	0
TRBV20-1	28567	broad.mit.edu	37	7	142334808	142334808	+	RNA	SNP	A	A	C			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:142334808A>C	ENST00000390394.3	+	0	308																											CAAGGCGTCGAGAAGGACAAG	0.512000											OREG0018395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	55					0	0	1	0	0
CD163L1	283316	broad.mit.edu	37	12	7522093	7522093	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:7522093G>A	ENST00000313599.3	-	15	3956	c.3899C>T	c.(3898-3900)tCg>tTg	p.S1300L	CD163L1_ENST00000396630.1_Missense_Mutation_p.S1300L|CD163L1_ENST00000416109.2_Missense_Mutation_p.S1310L			Q9NR16	C163B_HUMAN	CD163 molecule-like 1	1300	SRCR 12.					extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			breast(5)|central_nervous_system(3)|endometrium(8)|kidney(3)|large_intestine(18)|lung(37)|ovary(8)|prostate(3)|skin(6)|stomach(1)|urinary_tract(4)	96						CTGGCCAAACGAAGCGTCCCT	0.587000													65	65					0	0	1	0	0
GADD45B	4616	broad.mit.edu	37	19	2477183	2477183	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:2477183C>T	ENST00000215631.4	+	3	535	c.303C>T	c.(301-303)ctC>ctT	p.L101L	GADD45B_ENST00000587345.1_Silent_p.L101L	NM_015675.3	NP_056490.2	O75293	GA45B_HUMAN	growth arrest and DNA-damage-inducible, beta	101					activation of MAPKKK activity|apoptosis|cell differentiation|multicellular organismal development|response to stress					cervix(2)|lung(1)|ovary(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGCGCAGCTCCTGGGAGAGC	0.662000											OREG0025141	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	46					0	0	1	0	0
PRPF18	8559	broad.mit.edu	37	10	13629110	13629110	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:13629110C>T	ENST00000378572.3	+	1	184	c.24C>T	c.(22-24)atC>atT	p.I8I		NM_003675.3	NP_003666.1	Q99633	PRP18_HUMAN	pre-mRNA processing factor 18	8					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex				central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(5)|prostate(1)	17						AATCAGAGATCCTTCGGAAGC	0.612000													76	55					0	0	1	0	0
FTSJ2	29960	broad.mit.edu	37	7	2274938	2274938	+	Missense_Mutation	SNP	G	G	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:2274938G>T	ENST00000242257.8	-	3	588	c.560C>A	c.(559-561)cCt>cAt	p.P187H	FTSJ2_ENST00000407040.1_Missense_Mutation_p.P93H|FTSJ2_ENST00000440306.2_3'UTR|FTSJ2_ENST00000486040.1_5'UTR	NM_013393.1	NP_037525.1	Q9UI43	RRMJ2_HUMAN	FtsJ RNA methyltransferase homolog 2 (E. coli)	187					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		TGTCCCCCCAGGTTGCAGGAT	0.547000													29	54					1.88708e-17	1.9061e-17	1	1	0
IL37	27178	broad.mit.edu	37	2	113676334	113676334	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:113676334C>T	ENST00000263326.3	+	5	647	c.605C>T	c.(604-606)tCa>tTa	p.S202L	IL37_ENST00000353225.3_Missense_Mutation_p.S162L|IL37_ENST00000311328.2_Missense_Mutation_p.S176L|IL37_ENST00000349806.3_Missense_Mutation_p.S141L|IL37_ENST00000352179.3_Missense_Mutation_p.S181L	NM_014439.3	NP_055254.2	Q9NZH6	IL37_HUMAN	interleukin 37	202					immune response	cytosol|extracellular space|nucleus	cytokine activity|interleukin-1 receptor antagonist activity|interleukin-1 receptor binding			NS(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(7)|ovary(2)|skin(3)	19						ATTGAATTTTCATTTCAACCA	0.458000													19	47					0	0	1	0	0
MFSD4	148808	broad.mit.edu	37	1	205549915	205549915	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:205549915C>T	ENST00000367147.4	+	3	649	c.556C>T	c.(556-558)Cat>Tat	p.H186Y	MFSD4_ENST00000536357.1_Intron|MFSD4_ENST00000539267.1_Missense_Mutation_p.H186Y	NM_181644.4	NP_857595.3	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing 4	186					transmembrane transport	integral to membrane		p.H186N(1)		central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			CCACCTGTTCCATGTCTCCAG	0.617000													35	35					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179585769	179585769	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:179585769G>A	ENST00000589042.1	-	79	23201	c.22977C>T	c.(22975-22977)ttC>ttT	p.F7659F	TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Silent_p.F7342F|TTN_ENST00000342992.6_Silent_p.F6415F|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	7342	Ig-like 58.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAGAATTAATGAATGACATGT	0.423000													29	48					0	0	1	0	0
CCDC171	203238	broad.mit.edu	37	9	15920413	15920413	+	Missense_Mutation	SNP	T	T	C			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr9:15920413T>C	ENST00000380701.3	+	25	4074	c.3746T>C	c.(3745-3747)tTa>tCa	p.L1249S	CCDC171_ENST00000486641.2_3'UTR	NM_173550.2	NP_775821.2	Q6TFL3	CI093_HUMAN	coiled-coil domain containing 171	1249																	AATGCAAGTTTACAATCAGTA	0.313000													19	1					0	0	1	0	0
RNFT2	84900	broad.mit.edu	37	12	117217093	117217093	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:117217093C>T	ENST00000257575.4	+	7	1055	c.822C>T	c.(820-822)acC>acT	p.T274T	RNFT2_ENST00000319176.7_Intron|RNFT2_ENST00000407967.3_Silent_p.T274T|RNFT2_ENST00000392549.2_Silent_p.T274T			Q96EX2	RNFT2_HUMAN	ring finger protein, transmembrane 2	274						integral to membrane	zinc ion binding			endometrium(1)|large_intestine(3)|lung(1)|urinary_tract(1)	6	all_neural(191;0.117)|Medulloblastoma(191;0.163)			BRCA - Breast invasive adenocarcinoma(302;0.034)		AGTACATCACCATCGCCCTCA	0.557000													59	52					0	0	1	0	0
GRM3	2913	broad.mit.edu	37	7	86394705	86394705	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:86394705G>A	ENST00000361669.2	+	2	1343	c.244G>A	c.(244-246)Gat>Aat	p.D82N	GRM3_ENST00000439827.1_Missense_Mutation_p.D82N|GRM3_ENST00000546348.1_Intron|GRM3_ENST00000394720.2_Missense_Mutation_p.D80N|GRM3_ENST00000536043.1_Intron	NM_000840.2	NP_000831.2	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3	82					synaptic transmission	integral to plasma membrane				NS(2)|breast(6)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(43)|ovary(3)|pancreas(2)|prostate(4)|skin(25)|upper_aerodigestive_tract(5)	109	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AATCAACAAAGATGATTACTT	0.443000													55	77					0	0	1	0	0
FTH1P3	2498	broad.mit.edu	37	5	17354348	17354348	+	RNA	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:17354348C>T	ENST00000511821.1	+	0	207				FTH1P10_ENST00000401830.3_RNA																							GTTCCCTCTCCTCATGAGATT	0.473000													55	71					0	0	1	0	0
MAGEA4	4103	broad.mit.edu	37	X	151092728	151092728	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chrX:151092728C>T	ENST00000370335.1	+	3	859	c.592C>T	c.(592-594)Ccc>Tcc	p.P198S	MAGEA4_ENST00000370340.3_Missense_Mutation_p.P198S|MAGEA4_ENST00000276344.2_Missense_Mutation_p.P198S|MAGEA4_ENST00000393920.1_Missense_Mutation_p.P198S|MAGEA4_ENST00000370337.4_Missense_Mutation_p.P198S|MAGEA4_ENST00000360243.2_Missense_Mutation_p.P198S|MAGEA4_ENST00000393921.1_Missense_Mutation_p.P198S			P43358	MAGA4_HUMAN	melanoma antigen family A, 4	198	MAGE.						protein binding			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(1)|large_intestine(3)|lung(14)|ovary(2)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TCAGATCTTTCCCAAGACAGG	0.557000													72	1					0	0	1	0	0
ENAM	10117	broad.mit.edu	37	4	71508794	71508794	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr4:71508794G>A	ENST00000396073.3	+	9	1932	c.1651G>A	c.(1651-1653)Gaa>Aaa	p.E551K	ENAM_ENST00000472903.1_Intron	NM_031889.2	NP_114095.2	Q9NRM1	ENAM_HUMAN	enamelin	551					bone mineralization|odontogenesis	proteinaceous extracellular matrix	structural constituent of tooth enamel			haematopoietic_and_lymphoid_tissue(1)|ovary(3)|upper_aerodigestive_tract(2)	6			Lung(101;0.235)			ATACCCTGAGGAAATCCCTTC	0.428000													51	132					0	0	1	0	0
CDC25B	994	broad.mit.edu	37	20	3784181	3784181	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr20:3784181G>A	ENST00000245960.5	+	14	2184	c.1487G>A	c.(1486-1488)cGc>cAc	p.R496H	CDC25B_ENST00000340833.4_Missense_Mutation_p.R455H|CDC25B_ENST00000344256.6_Missense_Mutation_p.R432H|CDC25B_ENST00000379598.5_Missense_Mutation_p.R405H|CDC25B_ENST00000467519.1_3'UTR|CDC25B_ENST00000439880.2_Missense_Mutation_p.R482H	NM_004358.3|NM_021872.2|NM_021873.2	NP_004349.1|NP_068658.1|NP_068659.1	P30305	MPIP2_HUMAN	cell division cycle 25B	496	Rhodanese.				cell division|G2/M transition of mitotic cell cycle|mitosis|positive regulation of cell proliferation	cytosol|microtubule organizing center|nucleoplasm	protein binding|protein tyrosine phosphatase activity			NS(1)|large_intestine(4)|lung(10)|ovary(2)|prostate(1)	18						CGTGGGCCCCGCATGTGAGTC	0.612000													3	98					0	0	1	0	0
CD80	941	broad.mit.edu	37	3	119263714	119263714	+	Splice_Site	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:119263714C>T	ENST00000264246.3	-	3	463	c.100_splice	c.e3-1	p.G34_splice	CD80_ENST00000383668.3_Splice_Site_p.G34_splice|CD80_ENST00000383669.3_Splice_Site_p.G34_splice|CD80_ENST00000478182.1_Splice_Site_p.G34_splice	NM_005191.3	NP_005182.1	P33681	CD80_HUMAN	CD80 molecule	34					interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	12					Abatacept(DB01281)	GTGGATAACACCTATGGAGAG	0.438000													11	9					0	0	1	0	0
PLCXD3	345557	broad.mit.edu	37	5	41382018	41382018	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:41382018G>A	ENST00000377801.3	-	2	796	c.722C>T	c.(721-723)tCg>tTg	p.S241L	PLCXD3_ENST00000328457.3_Missense_Mutation_p.S241L			Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X domain containing 3	241					intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity	p.S241L(1)		central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						TATAAAAAACGATCCCTTCTT	0.507000													28	27					0	0	1	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501671	140501671	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:140501671C>T	ENST00000194152.1	+	1	91	c.91C>T	c.(91-93)Cgt>Tgt	p.R31C		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		31					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CGAGCCTATTCGTTATTCTGT	0.527000													33	1					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13692188	13692188	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:13692188C>T	ENST00000265104.4	-	79	13884	c.13780G>A	c.(13780-13782)Gac>Aac	p.D4594N		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4594					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TAGTTCAAGTCCGTTCGAACT	0.463000									Kartagener syndrome				27	35					0	0	1	0	0
TCEB3B	51224	broad.mit.edu	37	18	44561085	44561085	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr18:44561085G>A	ENST00000332567.4	-	1	903	c.551C>T	c.(550-552)cCt>cTt	p.P184L	KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron|KATNAL2_ENST00000592005.1_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	184					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						AGCGGGCTCAGGGCCCTCGGG	0.701000													17	34					0	0	1	0	0
SLAMF7	57823	broad.mit.edu	37	1	160720152	160720152	+	Silent	SNP	C	C	T	rs144271994		TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:160720152C>T	ENST00000368043.3	+	4	745	c.708C>T	c.(706-708)ctC>ctT	p.L236L	SLAMF7_ENST00000444090.2_Intron|SLAMF7_ENST00000458602.2_Intron|SLAMF7_ENST00000368042.3_Silent_p.L129L|SLAMF7_ENST00000458104.2_Intron|SLAMF7_ENST00000441662.2_Intron|SLAMF7_ENST00000359331.4_Silent_p.L236L	NM_021181.3	NP_067004.3	Q9NQ25	SLAF7_HUMAN	SLAM family member 7	236					cell adhesion|natural killer cell activation|natural killer cell mediated cytotoxicity	integral to membrane	receptor activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|prostate(1)|skin(4)	24	all_cancers(52;2.63e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TGGTGCCCCTCCTGCTCAGTC	0.502000													87	98					0	0	1	0	0
ERN2	10595	broad.mit.edu	37	16	23713998	23713998	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr16:23713998C>T	ENST00000256797.4	-	9	1192	c.1024G>A	c.(1024-1026)Gaa>Aaa	p.E342K	ERN2_ENST00000457008.2_Missense_Mutation_p.E294K	NM_033266.3	NP_150296.3	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signaling 2	294					apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		AAGCCAGTTTCATCCTTCCCC	0.478000													39	42					0	0	1	0	0
NLRP7	199713	broad.mit.edu	37	19	55451437	55451437	+	Silent	SNP	G	G	A	rs140816006		TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:55451437G>A	ENST00000446217.1	-	6	1236	c.834C>T	c.(832-834)ttC>ttT	p.F278F	NLRP7_ENST00000590030.1_Silent_p.F250F|NLRP7_ENST00000448121.2_Silent_p.F250F|NLRP7_ENST00000340844.2_Silent_p.F250F|NLRP7_ENST00000328092.5_Silent_p.F250F|NLRP7_ENST00000592784.1_Silent_p.F250F|NLRP7_ENST00000588756.1_Silent_p.F250F			Q8WX94	NALP7_HUMAN	NLR family, pyrin domain containing 7	250	NACHT.						ATP binding			autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(17)|liver(1)|lung(33)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	73				GBM - Glioblastoma multiforme(193;0.0325)		CATCGACCACGAACAGGATTC	0.577000													65	99					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126739070	126739070	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:126739070C>T	ENST00000251772.4	+	20	3921	c.3852C>T	c.(3850-3852)atC>atT	p.I1284I	PLXNA1_ENST00000393409.2_Silent_p.I1307I			Q9UIW2	PLXA1_HUMAN	plexin A1	1307					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		AGACAGACATCCACGAGCTGA	0.637000													42	50					0	0	1	0	0
OR8S1	341568	broad.mit.edu	37	12	48919933	48919933	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:48919933C>T	ENST00000310194.1	+	1	519	c.519C>T	c.(517-519)atC>atT	p.I173I	OR8S1_ENST00000551654.1_Intron	NM_001005203.2	NP_001005203.2	Q8NH09	OR8S1_HUMAN	olfactory receptor, family 8, subfamily S, member 1	173					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(11)|skin(4)	22						AAGCCAAAATCATTCACCACT	0.507000													53	58					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41743950	41743950	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:41743950G>A	ENST00000301178.4	+	7	1075	c.885G>A	c.(883-885)cgG>cgA	p.R295R	AXL_ENST00000359092.3_Silent_p.R295R|AXL_ENST00000593513.1_Silent_p.R27R	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	295	Fibronectin type-III 1.		R -> W (in a lung neuroendocrine carcinoma sample; somatic mutation).			integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						ATCAGCTTCGGCTAGGCAGCC	0.647000													136	111					0	0	1	0	0
ATG9B	285973	broad.mit.edu	37	7	150715110	150715110	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:150715110G>A	ENST00000605938.1	-	8	1975	c.1900C>T	c.(1900-1902)Ccg>Tcg	p.P634S	ATG9B_ENST00000444312.1_Missense_Mutation_p.P120S|ATG9B_ENST00000494791.1_5'UTR|ATG9B_ENST00000377974.2_Missense_Mutation_p.P634S	NM_173681.5	NP_775952.4	Q674R7	ATG9B_HUMAN	autophagy related 9B	634					autophagic vacuole assembly	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane				cervix(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(1)|ovary(4)|prostate(1)	14	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GTGAGGAGCGGGGACAGGAGC	0.617000											OREG0018444	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	6					0	0	1	0	0
GADD45B	4616	broad.mit.edu	37	19	2477146	2477146	+	Missense_Mutation	SNP	T	T	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:2477146T>A	ENST00000215631.4	+	3	498	c.266T>A	c.(265-267)aTc>aAc	p.I89N	GADD45B_ENST00000587345.1_Missense_Mutation_p.I89N	NM_015675.3	NP_056490.2	O75293	GA45B_HUMAN	growth arrest and DNA-damage-inducible, beta	89					activation of MAPKKK activity|apoptosis|cell differentiation|multicellular organismal development|response to stress					cervix(2)|lung(1)|ovary(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GACATCAACATCGTGCGGGTG	0.627000											OREG0025141	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	44	57					0	0	1	0	0
IKBKAP	8518	broad.mit.edu	37	9	111668626	111668626	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr9:111668626C>T	ENST00000374647.5	-	14	1907	c.1600G>A	c.(1600-1602)Gct>Act	p.A534T	IKBKAP_ENST00000537196.1_Missense_Mutation_p.A185T	NM_003640.3	NP_003631.2	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	534					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			NS(2)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						TCAGAAGAAGCTGCAGTCAAA	0.468000													56	67					0	0	1	0	0
CAMK1D	57118	broad.mit.edu	37	10	12870827	12870827	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:12870827G>A	ENST00000378847.3	+	11	1436	c.1099G>A	c.(1099-1101)Gga>Aga	p.G367R		NM_153498.2	NP_705718.1	Q8IU85	KCC1D_HUMAN	calcium/calmodulin-dependent protein kinase ID	367						calcium- and calmodulin-dependent protein kinase complex|cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)	16				GBM - Glioblastoma multiforme(1;3.16e-05)		CTCAGGAGTTGGAGCCGAGCG	0.622000													38	13					0	0	1	0	0
MON1B	22879	broad.mit.edu	37	16	77225524	77225524	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr16:77225524G>A	ENST00000248248.3	+	2	492	c.142G>A	c.(142-144)Gaa>Aaa	p.E48K	MON1B_ENST00000320859.6_Missense_Mutation_p.E48K|MON1B_ENST00000545553.1_Intron|MON1B_ENST00000439557.2_Missense_Mutation_p.E48K	NM_014940.2	NP_055755.1	Q7L1V2	MON1B_HUMAN	MON1 secretory trafficking family member B	48							protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	17						GGGCCTGGAGGAAACAGGTAT	0.582000													8	9					0	0	1	0	0
TMEM178A	130733	broad.mit.edu	37	2	39934218	39934218	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:39934218G>A	ENST00000281961.2	+	3	600	c.544G>A	c.(544-546)Ggc>Agc	p.G182S	TMEM178A_ENST00000482239.1_3'UTR	NM_152390.2	NP_689603.2			transmembrane protein 178A																		TGGCTTCCTCGGCATGGCCGT	0.483000													35	28					0	0	1	0	0
TP53I13	90313	broad.mit.edu	37	17	27896362	27896362	+	Silent	SNP	A	A	G			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr17:27896362A>G	ENST00000301057.7	+	3	283	c.168A>G	c.(166-168)cgA>cgG	p.R56R	RP11-68I3.2_ENST00000581474.1_RNA	NM_138349.2	NP_612358.3	Q8NBR0	P5I13_HUMAN	tumor protein p53 inducible protein 13	56						cytoplasm|integral to membrane|plasma membrane				NS(1)|kidney(1)|lung(1)|urinary_tract(1)	4				READ - Rectum adenocarcinoma(3;0.236)		CCTACACACGAGTGAGCCCAG	0.612000													2	12					0	0	1	0	0
C14orf37	145407	broad.mit.edu	37	14	58605023	58605023	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr14:58605023C>T	ENST00000267485.7	-	2	1248	c.1054G>A	c.(1054-1056)Ggt>Agt	p.G352S	C14orf37_ENST00000334342.5_5'UTR	NM_001001872.2	NP_001001872.2	Q86TY3	CN037_HUMAN	chromosome 14 open reading frame 37	352						integral to membrane	binding	p.E351_G352>DC(1)		breast(7)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|skin(1)	33						CCTTCCATACCCTCATGGCTT	0.557000													65	107					0	0	1	0	0
PARP6	56965	broad.mit.edu	37	15	72549780	72549780	+	Splice_Site	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr15:72549780G>A	ENST00000569795.1	-	13	1595	c.906_splice	c.e13-1	p.P303_splice	PARP6_ENST00000287196.9_Splice_Site_p.P303_splice|PARP6_ENST00000260376.7_Splice_Site_p.P303_splice|PARP6_ENST00000413097.2_5'UTR			Q2NL67	PARP6_HUMAN	poly (ADP-ribose) polymerase family, member 6	303							NAD+ ADP-ribosyltransferase activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(8)|skin(1)|urinary_tract(1)	18						ACAGACAGCTGGCTGAAAGGA	0.517000													31	67					0	0	1	0	0
RETNLB	84666	broad.mit.edu	37	3	108474710	108474710	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:108474710G>A	ENST00000295755.6	-	3	449	c.251C>T	c.(250-252)tCg>tTg	p.S84L	RETNLB_ENST00000482939.1_Intron	NM_032579.2	NP_115968.1	Q9BQ08	RETNB_HUMAN	resistin like beta	84					cell proliferation	extracellular region	hormone activity			endometrium(1)|kidney(3)|lung(10)|prostate(1)|skin(1)	16						AACATCCCACGAACCACAGCC	0.577000													52	66					0	0	1	0	0
OR6C6	283365	broad.mit.edu	37	12	55688965	55688965	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:55688965C>T	ENST00000358433.2	-	1	51	c.52G>A	c.(52-54)Gac>Aac	p.D18N		NM_001005493.1	NP_001005493.1	A6NF89	OR6C6_HUMAN	olfactory receptor, family 6, subfamily C, member 6	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(7)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						AACTGTGGGTCATCTGTCAAT	0.378000													25	26					0	0	1	0	0
MON1B	22879	broad.mit.edu	37	16	77225523	77225523	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr16:77225523G>A	ENST00000248248.3	+	2	491	c.141G>A	c.(139-141)gaG>gaA	p.E47E	MON1B_ENST00000320859.6_Silent_p.E47E|MON1B_ENST00000545553.1_Intron|MON1B_ENST00000439557.2_Silent_p.E47E	NM_014940.2	NP_055755.1	Q7L1V2	MON1B_HUMAN	MON1 secretory trafficking family member B	47							protein binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	17						AGGGCCTGGAGGAAACAGGTA	0.587000													8	9					0	0	1	0	0
SLC22A25	387601	broad.mit.edu	37	11	62996983	62996983	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr11:62996983G>A	ENST00000306494.6	-	1	141	c.142C>T	c.(142-144)Cgc>Tgc	p.R48C	SLC22A10_ENST00000535888.1_Intron|SLC22A10_ENST00000525620.1_Intron	NM_199352.3	NP_955384.3	Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	48					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						ACCCAGCAGCGATGATCAAGT	0.468000													18	64					0	0	1	0	0
EEFSEC	60678	broad.mit.edu	37	3	128060553	128060553	+	Missense_Mutation	SNP	T	T	G			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:128060553T>G	ENST00000254730.6	+	5	1318	c.1264T>G	c.(1264-1266)Tgc>Ggc	p.C422G	EEFSEC_ENST00000483457.1_Missense_Mutation_p.C367G|EEFSEC_ENST00000483569.1_3'UTR	NM_021937.3	NP_068756.2	P57772	SELB_HUMAN	eukaryotic elongation factor, selenocysteine-tRNA-specific	422						cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			NS(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)	25						GCCCGTCACCTGCCCTCGGCT	0.622000													33	62					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118362611	118362611	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr11:118362611C>T	ENST00000534358.1	+	15	4995	c.4972C>T	c.(4972-4974)Cgg>Tgg	p.R1658W	KMT2A_ENST00000354520.4_Missense_Mutation_p.R1617W|KMT2A_ENST00000389506.5_Missense_Mutation_p.R1655W	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		GTTGAATTCTCGGACTACCAG	0.468000													14	13					0	0	1	0	0
TBCCD1	55171	broad.mit.edu	37	3	186272727	186272727	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:186272727G>A	ENST00000424280.1	-	5	1485	c.1006C>T	c.(1006-1008)Cgt>Tgt	p.R336C	TBCCD1_ENST00000338733.5_Missense_Mutation_p.R336C|TBCCD1_ENST00000446782.1_Missense_Mutation_p.R240C	NM_001134415.1	NP_001127887.1	Q9NVR7	TBCC1_HUMAN	TBCC domain containing 1	336	C-CAP/cofactor C-like.				cell morphogenesis|maintenance of centrosome location|maintenance of Golgi location|regulation of cell migration|regulation of cell shape	spindle pole centrosome	binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(4)|ovary(1)|skin(1)	17	all_cancers(143;3.75e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.3e-21)	GBM - Glioblastoma multiforme(93;0.0474)		TCGTTGCAACGATGAATCTTT	0.468000													43	56					0	0	1	0	0
HSPA6	3310	broad.mit.edu	37	1	161495526	161495526	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:161495526G>A	ENST00000309758.4	+	1	1491	c.1078G>A	c.(1078-1080)Gag>Aag	p.E360K		NM_002155.3	NP_002146.2	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	360					response to unfolded protein		ATP binding			endometrium(3)|large_intestine(5)|lung(9)|prostate(2)|skin(2)	21	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CAACGGCAAGGAGCTGAACAA	0.577000													16	15					0	0	1	0	0
POMT1	10585	broad.mit.edu	37	9	134379613	134379613	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr9:134379613G>A	ENST00000423007.1	+	2	450	c.8G>A	c.(7-9)gGa>gAa	p.G3E	POMT1_ENST00000372228.3_Missense_Mutation_p.G3E|POMT1_ENST00000354713.4_Missense_Mutation_p.G3E|POMT1_ENST00000541219.1_Intron|POMT1_ENST00000341012.7_Intron|POMT1_ENST00000404875.2_Intron|POMT1_ENST00000402686.3_Missense_Mutation_p.G3E|POMT1_ENST00000419118.2_Intron	NM_001136113.1	NP_001129585.1	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1	3					multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	31		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		AAGATGTGGGGATTTTTGAAG	0.582000											OREG0019563	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	3					0	0	1	0	0
SEC16A	9919	broad.mit.edu	37	9	139368510	139368510	+	Silent	SNP	G	G	C			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr9:139368510G>C	ENST00000313050.7	-	1	3631	c.3558C>G	c.(3556-3558)ctC>ctG	p.L1186L	SEC16A_ENST00000290037.6_Silent_p.L1008L|SEC16A_ENST00000431893.2_Silent_p.L1008L|SEC16A_ENST00000371706.3_Silent_p.L1008L	NM_014866.1	NP_055681.1	O15027	SC16A_HUMAN	SEC16 homolog A (S. cerevisiae)	1008	Required for endoplasmic reticulum localization.				protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane				breast(1)|central_nervous_system(3)|endometrium(7)|kidney(5)|large_intestine(15)|lung(14)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		CCTGGTAATAGAGGGAGGCTG	0.522000													30	2					0	0	1	0	0
PRG3	10394	broad.mit.edu	37	11	57148170	57148170	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr11:57148170G>A	ENST00000287143.2	-	2	121	c.12C>T	c.(10-12)ctC>ctT	p.L4L		NM_006093.3	NP_006084.2	Q9Y2Y8	PRG3_HUMAN	proteoglycan 3	4					basophil activation|histamine biosynthetic process|immune response|leukotriene biosynthetic process|negative regulation of translation|neutrophil activation|positive regulation of interleukin-8 biosynthetic process|superoxide anion generation		sugar binding			large_intestine(3)|lung(5)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	13						GCAGGAGCAAGAGGCATTGCA	0.493000													8	12					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9085504	9085504	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:9085504C>T	ENST00000397910.4	-	1	6514	c.6311G>A	c.(6310-6312)aGa>aAa	p.R2104K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2104	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTCTGGATTTCTTTGCTTAGC	0.502000													85	94					0	0	1	0	0
IPO13	9670	broad.mit.edu	37	1	44426927	44426927	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:44426927C>T	ENST00000372343.3	+	14	2999	c.2337C>T	c.(2335-2337)ttC>ttT	p.F779F		NM_014652.3	NP_055467.3	O94829	IPO13_HUMAN	importin 13	779					protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(13)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	40	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				TCACTCTCTTCCAGCAAGGTA	0.582000													185	182					0	0	1	0	0
ARHGAP44	9912	broad.mit.edu	37	17	12832255	12832255	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr17:12832255G>A	ENST00000379672.5	+	7	774	c.474G>A	c.(472-474)caG>caA	p.Q158Q	ARHGAP44_ENST00000262444.9_Silent_p.Q158Q|ARHGAP44_ENST00000340825.3_Silent_p.Q158Q	NM_014859.4	NP_055674.4	Q17R89	RHG44_HUMAN	Rho GTPase activating protein 44	158	BAR.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			NS(2)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(7)|skin(1)|urinary_tract(1)	31						GGTGGCAGCAGACTTCCAAGT	0.512000													9	0					0	0	1	0	0
PLXNA1	5361	broad.mit.edu	37	3	126707544	126707544	+	Silent	SNP	T	T	G			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:126707544T>G	ENST00000251772.4	+	1	108	c.39T>G	c.(37-39)ggT>ggG	p.G13G	PLXNA1_ENST00000393409.2_Silent_p.G36G			Q9UIW2	PLXA1_HUMAN	plexin A1	36					axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity	p.G13G(4)		breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		CAGGCGGGGGTTCACAGCCCC	0.682000													5	40					0	0	1	0	0
MUC17	140453	broad.mit.edu	37	7	100677132	100677132	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:100677132C>T	ENST00000306151.4	+	3	2499	c.2435C>T	c.(2434-2436)cCt>cTt	p.P812L		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	812	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					ACAAGTATACCTGTCAGCATC	0.478000													199	286					0	0	1	0	0
CD80	941	broad.mit.edu	37	3	119263715	119263715	+	Splice_Site	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:119263715C>T	ENST00000264246.3	-	3	463		c.e3-1		CD80_ENST00000383668.3_Splice_Site|CD80_ENST00000383669.3_Splice_Site|CD80_ENST00000478182.1_Splice_Site	NM_005191.3	NP_005182.1	P33681	CD80_HUMAN	CD80 molecule						interspecies interaction between organisms|intracellular signal transduction|positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of signal transduction|positive regulation of T-helper 1 cell differentiation|positive regulation of transcription, DNA-dependent|T cell costimulation	intracellular	coreceptor activity|protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|ovary(1)|upper_aerodigestive_tract(2)	12					Abatacept(DB01281)	TGGATAACACCTATGGAGAGG	0.443000													11	9					0	0	1	0	0
KLHL30	377007	broad.mit.edu	37	2	239059547	239059547	+	Missense_Mutation	SNP	A	A	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:239059547A>T	ENST00000409223.1	+	8	1685	c.1578A>T	c.(1576-1578)gaA>gaT	p.E526D	KLHL30_ENST00000305959.4_Missense_Mutation_p.E508D			Q0D2K2	KLH30_HUMAN	kelch-like family member 30	526										lung(4)	4		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		AGGGCATGGAAGGTGACTACC	0.677000													12	15					0	0	1	0	0
CELSR3	1951	broad.mit.edu	37	3	48677985	48677985	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:48677985C>T	ENST00000544264.1	-	35	9328	c.9048G>A	c.(9046-9048)ctG>ctA	p.L3016L	CELSR3_ENST00000164024.4_Silent_p.L3011L			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	3011					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		ACCGGTTCTTCAGGATGCCTG	0.627000													7	8					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5391579	5391579	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:5391579C>T	ENST00000399537.4	-	17	5689	c.5341G>A	c.(5341-5343)Ggc>Agc	p.G1781S	TNRC18_ENST00000430969.1_Missense_Mutation_p.G1781S			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1781							DNA binding	p.R1780_G1781>SC(2)|p.G1781C(2)|p.G836C(1)|p.R835_G836>SC(1)		central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GCCGCCAGGCCCCTCTTGGTC	0.647000													14	16					0	0	1	0	0
FTH1P3	2498	broad.mit.edu	37	5	17354347	17354347	+	RNA	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:17354347C>T	ENST00000511821.1	+	0	206				FTH1P10_ENST00000401830.3_RNA																							TGTTCCCTCTCCTCATGAGAT	0.478000													56	73					0	0	1	0	0
C5orf38	153571	broad.mit.edu	37	5	2752552	2752552	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:2752552G>A	ENST00000515640.1	+	1	193	c.174G>A	c.(172-174)tgG>tgA	p.W58*	C5orf38_ENST00000397835.4_Nonsense_Mutation_p.W58*|C5orf38_ENST00000457752.2_Nonsense_Mutation_p.W58*|IRX2_ENST00000502957.1_Intron|C5orf38_ENST00000334000.3_Nonsense_Mutation_p.W58*|C5orf38_ENST00000505778.1_Nonsense_Mutation_p.W58*			Q86SI9	CEI_HUMAN	chromosome 5 open reading frame 38	58						extracellular region				endometrium(2)|large_intestine(1)|lung(1)	4				GBM - Glioblastoma multiforme(108;0.205)		GGGCGCCTTGGTTGCGAATTG	0.672000													6	11					0	0	1	0	0
LAIR2	3904	broad.mit.edu	37	19	55019312	55019312	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:55019312G>A	ENST00000301202.2	+	3	399	c.277G>A	c.(277-279)Gaa>Aaa	p.E93K	LAIR2_ENST00000351841.2_Missense_Mutation_p.E93K	NM_002288.4	NP_002279.2	Q6ISS4	LAIR2_HUMAN	leukocyte-associated immunoglobulin-like receptor 2	93	Ig-like C2-type.					extracellular region	receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)	18	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0967)		CTCAGTAAGTGAAGGAAATGC	0.493000													57	64					0	0	1	0	0
OR6F1	343169	broad.mit.edu	37	1	247875287	247875287	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:247875287G>A	ENST00000302084.2	-	1	818	c.771C>T	c.(769-771)ttC>ttT	p.F257F	RP11-634B7.4_ENST00000449298.1_RNA	NM_001005286.1	NP_001005286.1	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F, member 1	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|kidney(1)|large_intestine(5)|lung(34)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)	47	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GGACGTGAAGGAAAACTGTGG	0.527000													43	52					0	0	1	0	0
LILRB5	10990	broad.mit.edu	37	19	54760057	54760057	+	Silent	SNP	T	T	G			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:54760057T>G	ENST00000450632.1	-	4	554	c.477A>C	c.(475-477)tcA>tcC	p.S159S	LILRB5_ENST00000449561.2_Silent_p.S168S|LILRB5_ENST00000345866.6_Intron|LILRB5_ENST00000316219.5_Silent_p.S168S			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	168	Ig-like C2-type 2.				cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGAGCTTCTGTGAGTACAGGG	0.542000													22	26					0	0	1	0	0
TRIM51	84767	broad.mit.edu	37	11	55653314	55653314	+	Splice_Site	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr11:55653314G>A	ENST00000449290.2	+	2	502	c.411_splice	c.e2+1	p.R137_splice		NM_032681.3	NP_116070.2	Q9BSJ1	SPRY5_HUMAN	tripartite motif-containing 51	137						intracellular	zinc ion binding										GAGGAACGCCGGGTAAGTGAT	0.488000													12	13					0	0	1	0	0
ARID4A	5926	broad.mit.edu	37	14	58831412	58831412	+	Missense_Mutation	SNP	A	A	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr14:58831412A>T	ENST00000355431.3	+	20	2978	c.2605A>T	c.(2605-2607)Ata>Tta	p.I869L	ARID4A_ENST00000431317.2_Missense_Mutation_p.I869L|ARID4A_ENST00000348476.3_Missense_Mutation_p.I869L|ARID4A_ENST00000395168.3_Missense_Mutation_p.I869L	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	869					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity	p.I869V(1)		NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						AGAGAAAAAAATAAGAATTGA	0.323000													20	19					0	0	1	0	0
ROBO2	6092	broad.mit.edu	37	3	77611842	77611842	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:77611842C>T	ENST00000461745.1	+	10	2378	c.1478C>T	c.(1477-1479)tCa>tTa	p.S493L	ROBO2_ENST00000332191.8_Missense_Mutation_p.S493L|ROBO2_ENST00000487694.3_Missense_Mutation_p.S509L	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	493	Ig-like C2-type 5.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GCTACAAGTTCAAGTGGAGAG	0.413000													13	26					0	0	1	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36269237	36269237	+	Missense_Mutation	SNP	T	T	G			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:36269237T>G	ENST00000007510.4	+	4	389	c.245T>G	c.(244-246)gTg>gGg	p.V82G	ARHGAP33_ENST00000314737.5_Missense_Mutation_p.V82G|ARHGAP33_ENST00000221905.1_3'UTR|ARHGAP33_ENST00000378944.5_5'UTR			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	82	PX; atypical.				cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						AATGAGCTGGTGTTCGGGGTG	0.607000													51	56					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5391580	5391580	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:5391580C>T	ENST00000399537.4	-	17	5688	c.5340G>A	c.(5338-5340)agG>agA	p.R1780R	TNRC18_ENST00000430969.1_Silent_p.R1780R			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1780							DNA binding	p.R1780_G1781>SC(2)|p.R1780S(2)|p.R835S(1)|p.R835_G836>SC(1)		central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		CCGCCAGGCCCCTCTTGGTCA	0.647000													14	16					0	0	1	0	0
SPOCK3	50859	broad.mit.edu	37	4	167656173	167656173	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr4:167656173C>T	ENST00000357154.3	-	12	1347	c.1210G>A	c.(1210-1212)Gat>Aat	p.D404N	SPOCK3_ENST00000357545.4_Missense_Mutation_p.D401N|SPOCK3_ENST00000541637.1_Missense_Mutation_p.D306N|SPOCK3_ENST00000507137.1_5'UTR|SPOCK3_ENST00000512681.1_Missense_Mutation_p.D306N|SPOCK3_ENST00000506886.1_Missense_Mutation_p.D404N|SPOCK3_ENST00000421836.2_Missense_Mutation_p.D353N|SPOCK3_ENST00000511531.1_Missense_Mutation_p.D404N|SPOCK3_ENST00000504953.1_Missense_Mutation_p.D401N|SPOCK3_ENST00000511269.1_Missense_Mutation_p.D401N|SPOCK3_ENST00000541354.1_Missense_Mutation_p.D284N|SPOCK3_ENST00000535728.1_Missense_Mutation_p.D272N|SPOCK3_ENST00000502330.1_Missense_Mutation_p.D404N|SPOCK3_ENST00000534949.1_Missense_Mutation_p.D308N|SPOCK3_ENST00000510741.1_Missense_Mutation_p.D361N	NM_016950.2	NP_058646.2	Q9BQ16	TICN3_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	404	Asp-rich.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		tcgtcttcatcatcctcatca	0.353000													7	19					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55566486	55566486	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:55566486C>T	ENST00000373965.2	-	36	5302	c.4908G>A	c.(4906-4908)ctG>ctA	p.L1636L	PCDH15_ENST00000414778.1_Silent_p.L1633L	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0					equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				CTGTGCTTTTCAGCCTGTTCC	0.443000										HNSCC(58;0.16)			94	74					0	0	1	0	0
CARM1	10498	broad.mit.edu	37	19	11031727	11031727	+	Splice_Site	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:11031727G>A	ENST00000327064.4	+	14	1729	c.1537_splice	c.e14-1	p.G513_splice	CARM1_ENST00000344150.4_Splice_Site_p.G513_splice	NM_199141.1	NP_954592.1	Q86X55	CARM1_HUMAN	coactivator-associated arginine methyltransferase 1	513	Transactivation domain (By similarity).				cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(4)|urinary_tract(1)	13						TGGACACAGGGATGCCGACCG	0.667000													20	34					0	0	1	0	0
CYP4F12	66002	broad.mit.edu	37	19	15794549	15794549	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:15794549C>T	ENST00000550308.1	+	7	1274	c.894C>T	c.(892-894)ttC>ttT	p.F298F	CYP4F12_ENST00000324632.9_Silent_p.F298F	NM_023944.3	NP_076433.3			cytochrome P450, family 4, subfamily F, polypeptide 12											NS(1)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	41	Acute lymphoblastic leukemia(2;0.0367)					CTTTGGATTTCATTGATGTGC	0.438000													71	82					0	0	1	0	0
PTGFR	5737	broad.mit.edu	37	1	78959017	78959017	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:78959017G>A	ENST00000370756.3	+	2	826	c.589G>A	c.(589-591)Gaa>Aaa	p.E197K	PTGFR_ENST00000370758.1_Missense_Mutation_p.E197K|PTGFR_ENST00000370757.3_Missense_Mutation_p.E197K	NM_001039585.1	NP_001034674.1	P43088	PF2R_HUMAN	prostaglandin F receptor (FP)	197					parturition	extracellular region|integral to plasma membrane	prostaglandin F receptor activity			breast(6)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|prostate(1)|skin(2)|urinary_tract(1)	33				Colorectal(170;0.248)	Bimatoprost(DB00905)|Latanoprost(DB00654)|Travoprost(DB00287)	CAAAGACTGGGAAGATAGATT	0.403000													46	27					0	0	1	0	0
ZNF343	79175	broad.mit.edu	37	20	2464422	2464422	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr20:2464422G>A	ENST00000278772.4	-	6	1672	c.1185C>T	c.(1183-1185)acC>acT	p.T395T	RP4-734P14.4_ENST00000461548.1_Intron	NM_024325.4	NP_077301.4	Q6P1L6	ZN343_HUMAN	zinc finger protein 343	395					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(11)|skin(4)|upper_aerodigestive_tract(1)	25						GTTTTCTGAGGGTTGACTTAT	0.498000													32	40					0	0	1	0	0
CLTCL1	8218	broad.mit.edu	37	22	19209609	19209609	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr22:19209609G>A	ENST00000263200.10	-	16	2498	c.2426C>T	c.(2425-2427)cCt>cTt	p.P809L	CLTCL1_ENST00000353891.5_Missense_Mutation_p.P809L|CLTCL1_ENST00000427926.1_Missense_Mutation_p.P809L	NM_007098.3	NP_009029.3	P53675	CLH2_HUMAN	clathrin, heavy chain-like 1	809	Heavy chain arm.|Proximal segment.				anatomical structure morphogenesis|intracellular protein transport|mitosis|positive regulation of glucose import|receptor-mediated endocytosis	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|spindle|trans-Golgi network	protein binding|signal transducer activity|structural molecule activity			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(11)|lung(9)|ovary(5)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	49	Colorectal(54;0.0993)					GGTCCGGCTAGGGTTGACCTA	0.473000			T	?	ALCL								92	115					0	0	1	0	0
CHI3L2	1117	broad.mit.edu	37	1	111778306	111778306	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:111778306G>A	ENST00000445067.2	+	8	1297	c.526G>A	c.(526-528)Gaa>Aaa	p.E176K	CHI3L2_ENST00000524472.1_Missense_Mutation_p.E97K|CHI3L2_ENST00000369744.2_Missense_Mutation_p.E166K|CHI3L2_ENST00000466741.1_Missense_Mutation_p.E97K|CHI3L2_ENST00000369748.4_Missense_Mutation_p.E176K			Q15782	CH3L2_HUMAN	chitinase 3-like 2	176					chitin catabolic process	extracellular space	cation binding|chitinase activity	p.E176K(1)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(8)|prostate(1)	19		all_cancers(81;1.89e-05)|all_epithelial(167;7.36e-06)|all_lung(203;0.00018)|Lung NSC(277;0.000359)		Lung(183;0.0171)|Colorectal(144;0.0387)|all cancers(265;0.0464)|LUSC - Lung squamous cell carcinoma(189;0.0872)|Epithelial(280;0.0994)|COAD - Colon adenocarcinoma(174;0.141)		ATCCACCAAGGAAAGGCTTCT	0.448000													27	49					0	0	1	0	0
CEP152	22995	broad.mit.edu	37	15	49031358	49031358	+	Nonsense_Mutation	SNP	G	G	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr15:49031358G>T	ENST00000380950.2	-	27	4408	c.4221C>A	c.(4219-4221)tgC>tgA	p.C1407*	CEP152_ENST00000399334.3_Nonsense_Mutation_p.C1351*	NM_001194998.1|NM_014985.3	NP_001181927.1|NP_055800.2	O94986	CE152_HUMAN	centrosomal protein 152kDa	1351					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			breast(3)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(16)|lung(30)|ovary(1)|prostate(2)|skin(2)	63		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		GAGCTTGTTCGCACAGAGTTC	0.388000													39	51					1.30475e-32	1.32793e-32	1	1	0
BMP5	653	broad.mit.edu	37	6	55739504	55739504	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr6:55739504C>T	ENST00000370830.3	-	1	858	c.160G>A	c.(160-162)Gaa>Aaa	p.E54K	BMP5_ENST00000446683.2_Missense_Mutation_p.E54K	NM_021073.2	NP_066551.1	P22003	BMP5_HUMAN	bone morphogenetic protein 5	54					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity	p.E54K(1)		cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(19)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	45	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			GAGAGAATTTCCCTTTGTATT	0.438000													39	50					0	0	1	0	0
TRPV5	56302	broad.mit.edu	37	7	142625237	142625237	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:142625237G>A	ENST00000265310.1	-	7	1203	c.855C>T	c.(853-855)tcC>tcT	p.S285S	TRPV5_ENST00000442623.1_Silent_p.S285S	NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	285					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					CCTCTCCCCAGGAGTCGATCT	0.542000													36	53					0	0	1	0	0
HIST1H2AA	221613	broad.mit.edu	37	6	25726745	25726745	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr6:25726745C>T	ENST00000297012.3	-	1	45	c.11G>A	c.(10-12)cGa>cAa	p.R4Q		NM_170745.3	NP_734466.1	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa	4					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|endometrium(2)|large_intestine(2)|lung(8)	13						CTGCTTCCCTCGTCCAGACAT	0.522000													65	73					0	0	1	0	0
NBEA	26960	broad.mit.edu	37	13	35733690	35733690	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr13:35733690C>T	ENST00000400445.3	+	22	3916	c.3382C>T	c.(3382-3384)Cca>Tca	p.P1128S	NBEA_ENST00000379939.2_Missense_Mutation_p.P1128S|NBEA_ENST00000310336.4_Missense_Mutation_p.P1128S|NBEA_ENST00000540320.1_Missense_Mutation_p.P1128S	NM_015678.4	NP_056493.3	Q8NFP9	NBEA_HUMAN	neurobeachin	1128						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			NS(1)|breast(1)|endometrium(14)|kidney(4)|large_intestine(29)|lung(40)|ovary(9)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	108		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		GGATAATGGTCCATTGATAAC	0.343000													9	11					0	0	1	0	0
ROS1	6098	broad.mit.edu	37	6	117630061	117630061	+	Missense_Mutation	SNP	T	T	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr6:117630061T>A	ENST00000368508.3	-	41	6663	c.6465A>T	c.(6463-6465)ttA>ttT	p.L2155F	ROS1_ENST00000368507.3_Missense_Mutation_p.L2149F	NM_002944.2	NP_002935.2	P08922	ROS_HUMAN	c-ros oncogene 1 , receptor tyrosine kinase	2155	Protein kinase.				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity		TPM3_ENST00000368530/ROS1(4)|LRIG3/ROS1(2)|CD74_ENST00000009530/ROS1(32)|SLC34A2/ROS1(14)|EZR/ROS1(4)|GOPC/ROS1(14)|SDC4/ROS1(7)	NS(2)|breast(7)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(28)|lung(56)|ovary(8)|prostate(5)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(3)	162		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		GACCAAGAGTTAAAATCTCCC	0.393000			T	"""GOPC, SDC4, SLC34A2, EZR, LRIG3"""	"""glioblastoma, NSCLC"""								17	23					0	0	1	0	0
PSG6	5675	broad.mit.edu	37	19	43411173	43411173	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:43411173G>A	ENST00000187910.2	-	5	1206	c.1141C>T	c.(1141-1143)Ccc>Tcc	p.P381S	PSG6_ENST00000402603.4_Missense_Mutation_p.P288S|PSG6_ENST00000292125.2_Missense_Mutation_p.P381S	NM_001031850.3	NP_001027020.1			pregnancy specific beta-1-glycoprotein 6											central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(19)|ovary(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)	44		Prostate(69;0.00899)				GTAATTTGGGGGATAAAGAGC	0.453000													143	369					0	0	1	0	0
CYP4F24P	388514	broad.mit.edu	37	19	15890693	15890693	+	RNA	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:15890693C>T	ENST00000587443.2	-	0	104					NR_033864.1																						CTGCCCGAGGCCCAGCCAGGA	0.667000													16	17					0	0	1	0	0
PSMB1	5689	broad.mit.edu	37	6	170862327	170862327	+	Silent	SNP	A	A	G			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr6:170862327A>G	ENST00000262193.6	-	1	102	c.4T>C	c.(4-6)Ttg>Ctg	p.L2L		NM_002793.3	NP_002784.1	P20618	PSB1_HUMAN	proteasome (prosome, macropain) subunit, beta type, 1	2					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cell junction|cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			endometrium(2)|large_intestine(1)|lung(1)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.0563)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;7.5e-23)|BRCA - Breast invasive adenocarcinoma(81;4.88e-06)|GBM - Glioblastoma multiforme(31;0.00643)	Bortezomib(DB00188)	GTAGAGGACAACATCGCACGG	0.602000													9	13					0	0	1	0	0
TAOK2	9344	broad.mit.edu	37	16	29999120	29999120	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr16:29999120C>T	ENST00000308893.4	+	16	4570	c.3527C>T	c.(3526-3528)gCc>gTc	p.A1176V	TAOK2_ENST00000279394.3_Intron|TAOK2_ENST00000543033.1_Missense_Mutation_p.A1063V|TAOK2_ENST00000416441.2_Missense_Mutation_p.A1003V	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	1176					actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						CCCCCGTGGGCCATCCACACA	0.677000													28	27					0	0	1	0	0
AC007040.8	0	broad.mit.edu	37	2	71256050	71256050	+	RNA	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:71256050C>T	ENST00000434990.1	-	0	61																											CCCAAGGTGTCCAAGTCACAC	0.473000													4	2					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113113	209113113	+	Missense_Mutation	SNP	G	G	A	rs121913499		TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:209113113G>A	ENST00000415913.1	-	4	775	c.394C>T	c.(394-396)Cgt>Tgt	p.R132C	IDH1_ENST00000446179.1_Missense_Mutation_p.R132C|IDH1_ENST00000345146.2_Missense_Mutation_p.R132C			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132C(446)|p.R132G(125)|p.R132S(106)|p.G131_R132>VL(1)|p.R132V(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TAAGCATGACGACCTATGATG	0.398000			Mis		gliobastoma								45	40					0	0	1	0	0
KNDC1	85442	broad.mit.edu	37	10	135015287	135015287	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:135015287C>T	ENST00000304613.3	+	17	3293	c.3272C>T	c.(3271-3273)cCc>cTc	p.P1091L	KNDC1_ENST00000368572.2_Missense_Mutation_p.P1093L|KNDC1_ENST00000368571.2_Missense_Mutation_p.P1026L			Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND) containing 1	1091					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					NS(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(27)|ovary(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	60		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		AGCTGCAGCCCCGGCTGGTGC	0.721000													3	4					0	0	1	0	0
NUP210	23225	broad.mit.edu	37	3	13415253	13415253	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:13415253C>T	ENST00000254508.5	-	12	1634	c.1552G>A	c.(1552-1554)Gat>Aat	p.D518N		NM_024923.2	NP_079199.2	Q8TEM1	PO210_HUMAN	nucleoporin 210kDa	518					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				NS(1)|biliary_tract(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(10)|liver(1)|lung(16)|ovary(7)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	66	all_neural(104;0.187)					TTCTGCACATCATGTGCCTGG	0.582000													43	41					0	0	1	0	0
OR10J3	441911	broad.mit.edu	37	1	159284414	159284414	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:159284414G>A	ENST00000332217.5	-	1	35	c.36C>T	c.(34-36)ttC>ttT	p.F12F		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					CTTCAAAGAGGAACTCAGTCA	0.423000													77	88					0	0	1	0	0
CEP250	11190	broad.mit.edu	37	20	34090782	34090782	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr20:34090782C>T	ENST00000397527.1	+	30	5305	c.4585C>T	c.(4585-4587)Cta>Tta	p.L1529L	CEP250_ENST00000342580.4_Silent_p.L1473L	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	1529	Gln/Glu-rich.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GCATCAGCTTCTAGAACTTGA	0.522000													27	44					0	0	1	0	0
ZNF566	84924	broad.mit.edu	37	19	36940223	36940223	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:36940223G>A	ENST00000454319.1	-	5	1050	c.916C>T	c.(916-918)Cat>Tat	p.H306Y	ZNF566_ENST00000424129.2_Missense_Mutation_p.H305Y|ZNF566_ENST00000434377.2_Missense_Mutation_p.H305Y|ZNF566_ENST00000493391.1_Missense_Mutation_p.H201Y|ZNF566_ENST00000392170.2_Missense_Mutation_p.H306Y	NM_001145343.1|NM_001145344.1|NM_001145345.1	NP_001138815.1|NP_001138816.1|NP_001138817.1	Q969W8	ZN566_HUMAN	zinc finger protein 566	305					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(12)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24	Esophageal squamous(110;0.162)					TCCCCAGTATGAATTCTCTGA	0.408000													49	55					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128922363	128922363	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:128922363C>T	ENST00000375990.3	+	26	3216	c.2813C>T	c.(2812-2814)cCa>cTa	p.P938L	UGGT1_ENST00000259253.6_Missense_Mutation_p.P962L			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	962					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						AAAGGAGATCCAAGAATCGAG	0.368000													22	32					0	0	1	0	0
KCNK10	54207	broad.mit.edu	37	14	88652175	88652175	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr14:88652175C>T	ENST00000340700.5	-	7	1772	c.1321G>A	c.(1321-1323)Gac>Aac	p.D441N	KCNK10_ENST00000312350.5_Missense_Mutation_p.D446N|KCNK10_ENST00000319231.5_Missense_Mutation_p.D446N	NM_021161.4	NP_066984.1	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	441					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	47						ATGATGTTGTCCTCGGACGCA	0.547000													58	65					0	0	1	0	0
INO80D	54891	broad.mit.edu	37	2	206921284	206921284	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:206921284G>A	ENST00000403263.1	-	4	1006	c.602C>T	c.(601-603)tCa>tTa	p.S201L		NM_017759.4	NP_060229.3	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	201					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|cervix(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)|urinary_tract(2)	26						CTGCTGCTGTGAAGGTGCAGG	0.527000													7	13					0	0	1	0	0
AGO4	192670	broad.mit.edu	37	1	36306984	36306984	+	Missense_Mutation	SNP	T	T	C			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:36306984T>C	ENST00000373210.3	+	14	2188	c.1943T>C	c.(1942-1944)gTt>gCt	p.V648A		NM_017629.3	NP_060099.2			argonaute RISC catalytic component 4																		ACTAACATGGTTCGAGAGCTG	0.522000													3	91					0	0	1	0	0
DCSTAMP	81501	broad.mit.edu	37	8	105367117	105367117	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr8:105367117C>T	ENST00000297581.2	+	3	1091	c.1042C>T	c.(1042-1044)Caa>Taa	p.Q348*	DCSTAMP_ENST00000517991.1_Intron|DPYS_ENST00000521601.1_Intron	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	348					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											ACAAGGAACTCAAGATATTAT	0.368000													9	11					0	0	1	0	0
TBL3	10607	broad.mit.edu	37	16	2028377	2028377	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr16:2028377C>T	ENST00000568546.1	+	21	2326	c.2198C>T	c.(2197-2199)gCc>gTc	p.A733V		NM_006453.2	NP_006444.2	Q12788	TBL3_HUMAN	transducin (beta)-like 3	733					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity			breast(1)|endometrium(2)|kidney(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	18						GAGGCCCAGGCCGTGCTGGGT	0.672000													56	59					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57216787	57216787	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:57216787G>A	ENST00000343433.6	-	9	1397	c.1317C>T	c.(1315-1317)gcC>gcT	p.A439A	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	439										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						TGTCAATCATGGCCTCTTGCT	0.483000													34	33					0	0	1	0	0
UBASH3A	53347	broad.mit.edu	37	21	43855019	43855019	+	Missense_Mutation	SNP	G	G	A	rs145463901		TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr21:43855019G>A	ENST00000319294.6	+	10	1379	c.1348G>A	c.(1348-1350)Gat>Aat	p.D450N	UBASH3A_ENST00000398367.1_Missense_Mutation_p.D412N|UBASH3A_ENST00000291535.6_Missense_Mutation_p.D412N	NM_018961.3	NP_061834.1	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing A	450	Phosphatase-like.					cytosol|nucleus				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(9)|lung(12)|ovary(3)	28						CTTTGAAAACGATCCCCCATT	0.433000													52	49					0	0	1	0	0
NGEF	25791	broad.mit.edu	37	2	233834931	233834931	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:233834931C>T	ENST00000264051.3	-	3	654	c.376G>A	c.(376-378)Gaa>Aaa	p.E126K		NM_019850.2	NP_062824.2	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	126	Regulatory region; modulates activity toward RHOA, RAC1 and CDC42 (By similarity).				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(4)|endometrium(8)|kidney(2)|large_intestine(3)|lung(10)|ovary(3)|pancreas(1)|skin(4)	35		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		TACCTCATTTCCTGGGCTCCT	0.498000													29	40					0	0	1	0	0
MKI67	4288	broad.mit.edu	37	10	129914209	129914209	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:129914209G>A	ENST00000368654.3	-	7	838	c.463C>T	c.(463-465)Cct>Tct	p.P155S	MKI67_ENST00000368653.3_Intron	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	155					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TGTACCTGAGGATTTCCTGAA	0.383000													30	45					0	0	1	0	0
DSG1	1828	broad.mit.edu	37	18	28914025	28914025	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr18:28914025G>A	ENST00000257192.4	+	8	1077	c.865G>A	c.(865-867)Gag>Aag	p.E289K		NM_001942.2	NP_001933.2	Q02413	DSG1_HUMAN	desmoglein 1	289	Cadherin 3.				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			NS(2)|central_nervous_system(2)|endometrium(5)|kidney(7)|large_intestine(11)|lung(36)|ovary(3)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	76			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			AAATTTGCTCGAGATTAGAGT	0.328000													24	52					0	0	1	0	0
SLC25A23	79085	broad.mit.edu	37	19	6459558	6459558	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:6459558G>A	ENST00000301454.4	-	1	188	c.82C>T	c.(82-84)Cgc>Tgc	p.R28C	SLC25A23_ENST00000334510.5_Missense_Mutation_p.R28C	NM_024103.2	NP_077008.2	Q9BV35	SCMC3_HUMAN	solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23	28	EF-hand 1.				transmembrane transport	integral to membrane|mitochondrial inner membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|pancreas(1)|skin(1)	17						ACGTCCACGCGGCCATCCTTG	0.756000													37	39					0	0	1	0	0
OR6N1	128372	broad.mit.edu	37	1	158735840	158735840	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:158735840G>A	ENST00000335094.2	-	1	652	c.633C>T	c.(631-633)ttC>ttT	p.F211F		NM_001005185.1	NP_001005185.1	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N, member 1	211					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F211F(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(22)|ovary(1)|pancreas(1)|prostate(6)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_hematologic(112;0.0378)					GGATCAGCAGGAAGGTGGCTA	0.493000													43	60					0	0	1	0	0
ADAM19	8728	broad.mit.edu	37	5	156915320	156915320	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:156915320G>A	ENST00000257527.4	-	21	2581	c.2503C>T	c.(2503-2505)Cct>Tct	p.P835S	ADAM19_ENST00000517905.1_Missense_Mutation_p.P835S|ADAM19_ENST00000394020.1_Missense_Mutation_p.P837S|ADAM19_ENST00000430702.2_Missense_Mutation_p.P568S	NM_033274.3	NP_150377.1	Q9H013	ADA19_HUMAN	ADAM metallopeptidase domain 19	835					proteolysis	integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(33)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	53	Renal(175;0.00488)	Medulloblastoma(196;0.0359)|all_neural(177;0.14)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CGGCTTGGAGGAGGCCTCCTG	0.587000													93	10					0	0	1	0	0
CEACAM6	4680	broad.mit.edu	37	19	42265197	42265197	+	Missense_Mutation	SNP	C	C	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:42265197C>A	ENST00000199764.6	+	3	683	c.465C>A	c.(463-465)aaC>aaA	p.N155K	AC011513.4_ENST00000601409.1_RNA	NM_002483.4	NP_002474.3	P40199	CEAM6_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)	155	Ig-like C2-type 1.				cell-cell signaling|signal transduction	anchored to membrane|integral to plasma membrane				breast(1)|kidney(4)|large_intestine(1)|lung(4)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	18				OV - Ovarian serous cystadenocarcinoma(3;0.00575)|all cancers(3;0.0352)|Epithelial(262;0.0797)		ACAACTCCAACCCCGTGGAGG	0.557000													101	165					6.13486e-44	6.27571e-44	1	1	0
NLGN1	22871	broad.mit.edu	37	3	173322660	173322660	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:173322660G>A	ENST00000457714.1	+	3	701	c.272G>A	c.(271-273)gGg>gAg	p.G91E	NLGN1_ENST00000545397.1_Missense_Mutation_p.G91E|NLGN1_ENST00000401917.3_Missense_Mutation_p.G91E|NLGN1_ENST00000361589.4_Missense_Mutation_p.G91E	NM_014932.2	NP_055747.1	Q8N2Q7	NLGN1_HUMAN	neuroligin 1	91					calcium-dependent cell-cell adhesion|neuron cell-cell adhesion|neuronal signal transduction|positive regulation of dendritic spine development|positive regulation of excitatory postsynaptic membrane potential|positive regulation of intracellular protein kinase cascade|positive regulation of synaptogenesis|protein targeting|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|regulation of N-methyl-D-aspartate selective glutamate receptor activity|synapse assembly|synaptic vesicle targeting	cell junction|cell surface|dendrite|integral to plasma membrane|postsynaptic density|postsynaptic membrane	cell adhesion molecule binding|neurexin binding|receptor activity			breast(2)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|liver(2)|lung(54)|ovary(1)|pancreas(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	83	Ovarian(172;0.0025)		LUSC - Lung squamous cell carcinoma(14;5.36e-13)|Lung(28;9.49e-13)			CCACCAACAGGGGAACGTCGT	0.448000													44	67					0	0	1	0	0
CNNM2	54805	broad.mit.edu	37	10	104679626	104679626	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:104679626C>T	ENST00000369878.3	+	1	1513	c.1389C>T	c.(1387-1389)gcC>gcT	p.A463A	CNNM2_ENST00000369875.3_Silent_p.A463A|CNNM2_ENST00000457502.2_Silent_p.A221A|CNNM2_ENST00000433628.2_Silent_p.A463A	NM_017649.4	NP_060119.3	Q9H8M5	CNNM2_HUMAN	cyclin M2	463	CBS 1.				ion transport	integral to membrane				central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		CCGGCGAAGCCATCCTGGACT	0.577000													18	21					0	0	1	0	0
OR1L8	138881	broad.mit.edu	37	9	125330095	125330095	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr9:125330095C>T	ENST00000304865.2	-	1	743	c.662G>A	c.(661-663)cGa>cAa	p.R221Q		NM_001004454.1	NP_001004454.1	Q8NGR8	OR1L8_HUMAN	olfactory receptor, family 1, subfamily L, member 8	221					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						AGTGAGGATTCGTATATAAGA	0.428000													9	22					0	0	1	0	0
GLP1R	2740	broad.mit.edu	37	6	39053786	39053786	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr6:39053786G>A	ENST00000373256.4	+	13	1372	c.1329G>A	c.(1327-1329)ctG>ctA	p.L443L		NM_002062.3	NP_002053.3	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor	443					activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			breast(5)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	31					Exenatide(DB01276)|Glucagon recombinant(DB00040)	CCAGCAGCCTGAGCAGTGGAG	0.637000													70	73					0	0	1	0	0
NPC1L1	29881	broad.mit.edu	37	7	44561409	44561409	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:44561409G>A	ENST00000289547.4	-	12	2910	c.2855C>T	c.(2854-2856)tCc>tTc	p.S952F	NPC1L1_ENST00000381160.3_Missense_Mutation_p.S952F|NPC1L1_ENST00000546276.1_Missense_Mutation_p.S906F	NM_013389.2	NP_037521.2	Q9UHC9	NPCL1_HUMAN	NPC1-like 1	952					cholesterol biosynthetic process|intestinal cholesterol absorption|lipoprotein metabolic process	apical plasma membrane|cytoplasmic vesicle membrane|integral to membrane	hedgehog receptor activity|protein binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|large_intestine(7)|lung(27)|ovary(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	57					Ezetimibe(DB00973)	ATCCACCCAGGAGGAGGCAGG	0.607000													28	34					0	0	1	0	0
USP20	10868	broad.mit.edu	37	9	132618591	132618591	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr9:132618591C>T	ENST00000315480.4	+	4	245	c.87C>T	c.(85-87)acC>acT	p.T29T	USP20_ENST00000372429.3_Silent_p.T29T|USP20_ENST00000358355.1_Silent_p.T29T			Q9Y2K6	UBP20_HUMAN	ubiquitin specific peptidase 20	29					endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|urinary_tract(1)	11		Ovarian(14;0.00556)				CACAGGGAACCTGTCAGTCGT	0.592000													93	7					0	0	1	0	0
C11orf35	256329	broad.mit.edu	37	11	558970	558970	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr11:558970G>A	ENST00000329451.3	-	2	106	c.44C>T	c.(43-45)tCg>tTg	p.S15L	RP11-496I9.1_ENST00000527113.1_RNA|RP11-496I9.1_ENST00000527620.1_RNA	NM_173573.2	NP_775844.2	Q8IXW0	CK035_HUMAN	chromosome 11 open reading frame 35	15										NS(1)|breast(1)|central_nervous_system(1)|lung(4)|pancreas(1)	8		all_cancers(49;2.16e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;7.18e-28)|Epithelial(43;6.93e-27)|OV - Ovarian serous cystadenocarcinoma(40;6.97e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACCACTGACCGACTCTTGCTC	0.652000													21	0					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128490101	128490101	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:128490101C>T	ENST00000325888.8	+	31	5532	c.5271C>T	c.(5269-5271)ccC>ccT	p.P1757P	FLNC_ENST00000346177.6_Intron	NM_001458.4	NP_001449.3	Q14315	FLNC_HUMAN	filamin C, gamma	1757	Hinge 1.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						ACGCTCCTccccggcccggcg	0.687000													2	2					0	0	1	0	0
TOX	9760	broad.mit.edu	37	8	59852045	59852045	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr8:59852045G>A	ENST00000361421.1	-	3	447	c.227C>T	c.(226-228)cCt>cTt	p.P76L		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	76						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				TGGGAGGGAAGGAGGAGTAAT	0.458000													31	45					0	0	1	0	0
ZNF354A	6940	broad.mit.edu	37	5	178140337	178140337	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:178140337G>A	ENST00000335815.2	-	5	739	c.542C>T	c.(541-543)cCc>cTc	p.P181L		NM_005649.2	NP_005640.2	O60765	Z354A_HUMAN	zinc finger protein 354A	181					regulation of transcription from RNA polymerase II promoter|sensory perception of sound|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(7)|lung(3)|ovary(2)|skin(2)|stomach(2)	19	all_cancers(89;0.000536)|Renal(175;0.000159)|all_epithelial(37;0.000221)|Lung NSC(126;0.00308)|all_lung(126;0.00536)	all_cancers(40;0.0452)|all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.185)		TTTTTCTCTGGGAAGTATCTG	0.358000													84	112					0	0	1	0	0
ELMOD3	84173	broad.mit.edu	37	2	85598616	85598616	+	Missense_Mutation	SNP	A	A	G			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:85598616A>G	ENST00000315658.7	+	8	797	c.538A>G	c.(538-540)Aag>Gag	p.K180E	ELMOD3_ENST00000409344.3_Missense_Mutation_p.K180E|ELMOD3_ENST00000409013.3_Missense_Mutation_p.K180E|ELMOD3_ENST00000393852.4_Missense_Mutation_p.K180E|ELMOD3_ENST00000490508.1_3'UTR|ELMOD3_ENST00000409890.2_Missense_Mutation_p.K180E|ELMOD3_ENST00000428955.2_Missense_Mutation_p.K180E	NM_032213.4	NP_115589.2	Q96FG2	ELMD3_HUMAN	ELMO/CED-12 domain containing 3	180	ELMO.				phagocytosis	cytoskeleton				endometrium(1)|kidney(1)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)	12						GACCATCTATAAGAAGCTGAC	0.552000													37	45					0	0	1	0	0
CSMD2	114784	broad.mit.edu	37	1	34011768	34011768	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:34011768C>T	ENST00000373381.4	-	57	9145	c.8969G>A	c.(8968-8970)cGt>cAt	p.R2990H		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	2963	Sushi 22.					integral to membrane|plasma membrane	protein binding	p.R2846H(1)		NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				GTCCCCCAAACGGATGCCATG	0.567000													19	27					0	0	1	0	0
ABCA4	24	broad.mit.edu	37	1	94564545	94564545	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:94564545G>A	ENST00000370225.3	-	6	659	c.573C>T	c.(571-573)ttC>ttT	p.F191F	ABCA4_ENST00000535735.1_Silent_p.F191F	NM_000350.2	NP_000341.2	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 4	191					phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(2)|breast(6)|central_nervous_system(5)|endometrium(9)|haematopoietic_and_lymphoid_tissue(5)|kidney(10)|large_intestine(25)|lung(57)|ovary(4)|pancreas(1)|prostate(4)|skin(10)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	147		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		CTCCATGAGCGAACTGCAGGG	0.587000													9	14					0	0	1	0	0
TNR	7143	broad.mit.edu	37	1	175372638	175372638	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:175372638G>A	ENST00000367674.1	-	4	1322	c.614C>T	c.(613-615)cCg>cTg	p.P205L	TNR_ENST00000263525.2_Missense_Mutation_p.P205L	NM_003285.2	NP_003276.3	Q92752	TENR_HUMAN	tenascin R	205	Cys-rich.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				NS(3)|breast(7)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(29)|lung(98)|ovary(4)|pancreas(5)|prostate(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	177	Renal(580;0.146)					GCAACCCAGCGGGCAGTAGGG	0.597000													135	167					0	0	1	0	0
PCDHA2	56146	broad.mit.edu	37	5	140175559	140175559	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:140175559C>T	ENST00000526136.1	+	1	1010	c.1010C>T	c.(1009-1011)tCa>tTa	p.S337L	PCDHA1_ENST00000394633.3_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000520672.2_Missense_Mutation_p.S337L|PCDHA2_ENST00000378132.1_Missense_Mutation_p.S337L	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGTAAAATTTCATTAAAACTT	0.413000													21	3					0	0	1	0	0
C8B	732	broad.mit.edu	37	1	57399065	57399065	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:57399065C>T	ENST00000543257.1	-	11	1905	c.1339G>A	c.(1339-1341)Gaa>Aaa	p.E447K	C8B_ENST00000371237.4_Missense_Mutation_p.E499K|C8B_ENST00000535057.1_Missense_Mutation_p.E437K	NM_001278543.1	NP_001265472.1	P07358	CO8B_HUMAN	complement component 8, beta polypeptide	499	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	membrane attack complex		p.E499K(1)		breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(1)|lung(20)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	52						GAACTAACTTCCTTCTGGAAC	0.527000													23	33					0	0	1	0	0
TRPM8	79054	broad.mit.edu	37	2	234878989	234878989	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:234878989G>A	ENST00000324695.4	+	17	2314	c.2274G>A	c.(2272-2274)atG>atA	p.M758I	TRPM8_ENST00000433712.2_Intron	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	758						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	TGCTGCTCATGGATTTCCATT	0.557000													199	267					0	0	1	0	0
DENND6B	414918	broad.mit.edu	37	22	50750841	50750841	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr22:50750841G>A	ENST00000413817.2	-	19	1637	c.1566C>T	c.(1564-1566)atC>atT	p.I522I		NM_001001794.3	NP_001001794.3			DENN/MADD domain containing 6B																		TCCAGGTCTCGATGTTCTGCA	0.622000													13	12					0	0	1	0	0
MYO18B	84700	broad.mit.edu	37	22	26168438	26168438	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr22:26168438C>T	ENST00000335473.7	+	7	2080	c.1830C>T	c.(1828-1830)gtC>gtT	p.V610V	MYO18B_ENST00000536101.1_Silent_p.V610V|MYO18B_ENST00000407587.2_Silent_p.V610V	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	610	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						ATCTGATTGTCCTCCAGCCCC	0.637000													29	32					0	0	1	0	0
MYH4	4622	broad.mit.edu	37	17	10351974	10351974	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr17:10351974G>A	ENST00000255381.2	-	32	4602	c.4492C>T	c.(4492-4494)Cat>Tat	p.H1498Y	CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1498					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle	p.H1498D(1)		NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						GTTTCAAGATGATCCAGGGAT	0.428000													56	4					0	0	1	0	0
CC2D2B	387707	broad.mit.edu	37	10	97772304	97772304	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:97772304G>A	ENST00000344386.3	+	4	300	c.136G>A	c.(136-138)Gag>Aag	p.E46K	ENTPD1-AS1_ENST00000452728.1_RNA|ENTPD1-AS1_ENST00000454638.1_RNA|CC2D2B_ENST00000410012.2_Missense_Mutation_p.E46K|ENTPD1-AS1_ENST00000451364.1_RNA|RP11-690P14.4_ENST00000475252.2_Intron|CC2D2B_ENST00000371198.2_Intron|ENTPD1-AS1_ENST00000416301.1_RNA	NM_001001732.3	NP_001001732.2	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B	46										large_intestine(1)|lung(7)|ovary(1)|urinary_tract(1)	10		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		AGATCAAACAGAGGTCTTGCA	0.313000													10	15					0	0	1	0	0
GAK	2580	broad.mit.edu	37	4	898519	898519	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr4:898519G>A	ENST00000314167.4	-	5	541	c.431C>T	c.(430-432)tCg>tTg	p.S144L	GAK_ENST00000511163.1_Missense_Mutation_p.S65L	NM_005255.2	NP_005246.2	O14976	GAK_HUMAN	cyclin G associated kinase	144	Protein kinase.		S -> L.		cell cycle	focal adhesion|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|heat shock protein binding|protein serine/threonine kinase activity	p.S144L(1)		autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(16)|skin(7)|urinary_tract(2)	39				Colorectal(103;0.219)		CGTGTCGCACGAAAGGGGGCC	0.552000													19	0					0	0	1	0	0
OR6C68	403284	broad.mit.edu	37	12	55886782	55886782	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:55886782C>T	ENST00000379662.1	+	1	636	c.636C>T	c.(634-636)atC>atT	p.I212I	RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA|OR6C68_ENST00000548615.1_Silent_p.I207I|RP11-110A12.2_ENST00000554049.1_RNA			A6NDL8	O6C68_HUMAN	olfactory receptor, family 6, subfamily C, member 68	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	15						CCTTTATTATCACTCTTGTAT	0.348000													10	14					0	0	1	0	0
FNDC1	84624	broad.mit.edu	37	6	159653120	159653120	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr6:159653120C>T	ENST00000297267.9	+	11	1776	c.1576C>T	c.(1576-1578)Cgc>Tgc	p.R526C	FNDC1_ENST00000340366.6_Missense_Mutation_p.R463C	NM_032532.2	NP_115921.2	Q4ZHG4	FNDC1_HUMAN	fibronectin type III domain containing 1	526						extracellular region				NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(29)|liver(2)|lung(23)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(3)	93		Breast(66;0.000781)|Ovarian(120;0.0308)|Prostate(117;0.195)		OV - Ovarian serous cystadenocarcinoma(65;2.6e-16)|BRCA - Breast invasive adenocarcinoma(81;1.06e-05)		ACCCCAGCTTCGCGCCAAGAA	0.562000													20	11					0	0	1	0	0
SDPR	8436	broad.mit.edu	37	2	192701266	192701266	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:192701266C>T	ENST00000304141.4	-	2	990	c.661G>A	c.(661-663)Gaa>Aaa	p.E221K		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	221						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TCCACCTTTTCCTCGGCACTG	0.483000													63	72					0	0	1	0	0
NPY5R	4889	broad.mit.edu	37	4	164272156	164272156	+	Missense_Mutation	SNP	A	A	G			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr4:164272156A>G	ENST00000515560.1	+	4	2253	c.731A>G	c.(730-732)aAc>aGc	p.N244S	NPY5R_ENST00000338566.3_Missense_Mutation_p.N244S|NPY5R_ENST00000506953.1_Missense_Mutation_p.N244S			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	244					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				GGATTGTCCAACAAAGAAAAC	0.383000													20	55					0	0	1	0	0
KIAA1429	25962	broad.mit.edu	37	8	95541354	95541354	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr8:95541354G>A	ENST00000297591.5	-	7	899	c.824C>T	c.(823-825)cCt>cTt	p.P275L	KIAA1429_ENST00000421249.2_Missense_Mutation_p.P275L|KIAA1429_ENST00000437199.1_Missense_Mutation_p.P275L	NM_015496.4	NP_056311.2	Q69YN4	VIR_HUMAN	KIAA1429	275	Glu-rich.				mRNA processing|RNA splicing	nucleus				NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|kidney(5)|large_intestine(16)|lung(28)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	66	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			ttcctcctcAGGAATACTGTC	0.438000													8	6					0	0	1	0	0
DCTN2	10540	broad.mit.edu	37	12	57929324	57929324	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:57929324G>A	ENST00000548249.1	-	4	474	c.207C>T	c.(205-207)ttC>ttT	p.F69F	DCTN2_ENST00000543672.1_Silent_p.F74F|DCTN2_ENST00000551400.1_5'UTR|DCTN2_ENST00000434715.3_Silent_p.F74F|DCTN2_ENST00000537439.1_Silent_p.F46F	NM_001261412.1|NM_001261413.1	NP_001248341.1|NP_001248342.1	Q13561	DCTN2_HUMAN	dynactin 2 (p50)	69					cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule|vesicle	motor activity|protein binding			endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|upper_aerodigestive_tract(2)	11						TACGATCTGAGAAATCTGCCA	0.448000													39	66					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	662547	662547	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:662547G>A	ENST00000266383.5	+	14	1471	c.1458G>A	c.(1456-1458)ctG>ctA	p.L486L		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	486						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			GGGAGGGCCTGCTGGCCCCCT	0.627000													41	48					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100847495	100847495	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr8:100847495C>T	ENST00000358544.2	+	53	9871	c.9760C>T	c.(9760-9762)Cga>Tga	p.R3254*	VPS13B_ENST00000357162.2_Nonsense_Mutation_p.R3229*|VPS13B_ENST00000395996.1_3'UTR	NM_017890.4	NP_060360.3	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	3254					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CCCTAGTCCTCGAGTAATTAT	0.343000													14	26					0	0	1	0	0
DEF8	54849	broad.mit.edu	37	16	90032355	90032355	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr16:90032355C>T	ENST00000563594.1	+	13	2337	c.1340C>T	c.(1339-1341)cCc>cTc	p.P447L	DEF8_ENST00000567874.1_Missense_Mutation_p.P387L|DEF8_ENST00000268676.7_Missense_Mutation_p.P508L|DEF8_ENST00000570182.1_Missense_Mutation_p.P437L|DEF8_ENST00000569453.1_Missense_Mutation_p.P447L|DEF8_ENST00000563795.1_Missense_Mutation_p.P430L	NM_001242818.1|NM_001242819.1	NP_001229747.1|NP_001229748.1	Q6ZN54	DEFI8_HUMAN	differentially expressed in FDCP 8 homolog (mouse)	508					intracellular signal transduction		zinc ion binding			central_nervous_system(1)|cervix(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	12		all_cancers(9;7.59e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.0019)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		GAGCCAGGTCCCGATGTGGAG	0.637000													14	16					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9070067	9070067	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:9070067G>A	ENST00000397910.4	-	3	17582	c.17379C>T	c.(17377-17379)atC>atT	p.I5793I		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	5795	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCACAGTGTTGATCTCCTCAG	0.458000													37	30					0	0	1	0	0
ADCYAP1R1	117	broad.mit.edu	37	7	31146205	31146205	+	Missense_Mutation	SNP	T	T	G			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:31146205T>G	ENST00000304166.4	+	16	1603	c.1314T>G	c.(1312-1314)agT>agG	p.S438R	ADCYAP1R1_ENST00000396211.2_Missense_Mutation_p.S466R|ADCYAP1R1_ENST00000409363.1_Missense_Mutation_p.S417R|ADCYAP1R1_ENST00000409489.1_Missense_Mutation_p.S494R	NM_001118.4|NM_001199635.1|NM_001199636.1	NP_001109.2|NP_001186564.1|NP_001186565.1	P41586	PACR_HUMAN	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I	438					activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|spermatogenesis	integral to plasma membrane	vasoactive intestinal polypeptide receptor activity			endometrium(1)|large_intestine(4)|liver(2)|lung(24)|ovary(1)|skin(2)|stomach(1)	35						TGGCCAGCAGTGGGGTGAATG	0.587000													29	39					0	0	1	0	0
EPHB1	2047	broad.mit.edu	37	3	134670529	134670529	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:134670529C>T	ENST00000398015.3	+	3	810	c.440C>T	c.(439-441)tCc>tTc	p.S147F	EPHB1_ENST00000488154.1_3'UTR	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	147						integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						GAGAGCTTCTCCCAGGTGGAC	0.493000													60	80					0	0	1	0	0
PALLD	23022	broad.mit.edu	37	4	169611778	169611778	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr4:169611778G>A	ENST00000335742.7	+	7	1571	c.214G>A	c.(214-216)Gaa>Aaa	p.E72K	PALLD_ENST00000261509.6_Missense_Mutation_p.E454K|PALLD_ENST00000333488.4_Missense_Mutation_p.E331K|PALLD_ENST00000512127.1_Missense_Mutation_p.E72K|PALLD_ENST00000505667.1_Missense_Mutation_p.E454K			Q8WX93	PALLD_HUMAN	palladin, cytoskeletal associated protein	454					cytoskeleton organization	actin filament|focal adhesion|lamellipodium|nucleus|ruffle|sarcomere	actin binding|muscle alpha-actinin binding			breast(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(6)|liver(2)|lung(18)|ovary(3)|prostate(3)|skin(4)	48		Prostate(90;0.00996)|Renal(120;0.0203)|Melanoma(52;0.144)		GBM - Glioblastoma multiforme(119;0.204)		AGCCGTGGCGGAAGGCCAGGT	0.502000									Pancreatic Cancer, Familial Clustering of				67	38					0	0	1	0	0
ANAPC1	64682	broad.mit.edu	37	2	112608394	112608394	+	Missense_Mutation	SNP	T	T	C			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:112608394T>C	ENST00000341068.3	-	14	2381	c.1609A>G	c.(1609-1611)Act>Gct	p.T537A		NM_022662.3	NP_073153.1	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	537					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm		p.T537A(5)		NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(7)|lung(16)|pancreas(1)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	49						GGCTTTGGAGTACTAACGCCA	0.433000													3	103					0	0	1	0	0
TRIM7	81786	broad.mit.edu	37	5	180622600	180622600	+	Nonsense_Mutation	SNP	C	C	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:180622600C>A	ENST00000393315.1	-	7	1175	c.478G>T	c.(478-480)Gag>Tag	p.E160*	TRIM7_ENST00000274773.7_Nonsense_Mutation_p.E368*|TRIM7_ENST00000504241.1_5'UTR|TRIM7_ENST00000422067.2_Nonsense_Mutation_p.E160*|TRIM7_ENST00000393319.3_Nonsense_Mutation_p.E186*|TRIM7_ENST00000361809.3_Nonsense_Mutation_p.E160*|CTC-338M12.6_ENST00000512508.1_RNA	NM_203296.1	NP_976041.1	Q9C029	TRIM7_HUMAN	tripartite motif containing 7	368						cytoplasm|nucleus	zinc ion binding			NS(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(2)|skin(1)|stomach(1)	17	all_cancers(89;6.03e-06)|all_epithelial(37;7.1e-07)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.000172)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;2e-06)|Epithelial(171;1.35e-05)|OV - Ovarian serous cystadenocarcinoma(192;0.000128)|Kidney(146;0.0674)|GBM - Glioblastoma multiforme(465;0.0802)		TGGGCCCGCTCGCCGAGGCGC	0.667000													3	98					1	1	1	1	0
IGHV3-7	28452	broad.mit.edu	37	14	106518644	106518644	+	RNA	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr14:106518644G>A	ENST00000390598.2	-	0	185																											GAGTCTCAGGGACCCCCCAGG	0.597000													96	115					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3653743	3653743	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr17:3653743G>A	ENST00000263087.4	-	16	2025	c.1927C>T	c.(1927-1929)Cag>Tag	p.Q643*		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	643					cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		CCGAAGTACTGGAGTCCTGGG	0.627000													29	2					0	0	1	0	0
ANKAR	150709	broad.mit.edu	37	2	190571836	190571836	+	Missense_Mutation	SNP	A	A	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:190571836A>T	ENST00000520309.1	+	9	2171	c.2083A>T	c.(2083-2085)Aat>Tat	p.N695Y	ANKAR_ENST00000281412.6_Missense_Mutation_p.N459Y|ANKAR_ENST00000313581.4_Missense_Mutation_p.N695Y|ANKAR_ENST00000438402.2_Missense_Mutation_p.N695Y|ANKAR_ENST00000431575.2_Missense_Mutation_p.N624Y	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	695						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			aataaaattaaatattCCTGA	0.289000													6	4					0	0	1	0	0
LMO3	55885	broad.mit.edu	37	12	16753611	16753611	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:16753611G>A	ENST00000320122.6	-	2	706	c.184C>T	c.(184-186)Ctt>Ttt	p.L62F	LMO3_ENST00000541846.1_Missense_Mutation_p.L62F|LMO3_ENST00000441439.2_Missense_Mutation_p.L62F|LMO3_ENST00000537304.1_Missense_Mutation_p.L62F|LMO3_ENST00000541295.1_Missense_Mutation_p.L80F|LMO3_ENST00000447609.1_Missense_Mutation_p.L62F|LMO3_ENST00000535535.1_Missense_Mutation_p.L62F|LMO3_ENST00000354662.1_Missense_Mutation_p.L62F|LMO3_ENST00000540848.1_Missense_Mutation_p.L62F|LMO3_ENST00000534946.1_Missense_Mutation_p.L62F|LMO3_ENST00000540445.1_Intron|LMO3_ENST00000261169.6_Missense_Mutation_p.L73F|LMO3_ENST00000537568.1_Intron	NM_001243611.1	NP_001230540.1	Q8TAP4	LMO3_HUMAN	LIM domain only 3 (rhombotin-like 2)	62	LIM zinc-binding 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent		zinc ion binding			endometrium(2)|large_intestine(2)|skin(1)	5		Hepatocellular(102;0.244)				CTGCGACAAAGGATAAGATTA	0.448000													24	34					0	0	1	0	0
CNPPD1	27013	broad.mit.edu	37	2	220037718	220037718	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:220037718G>A	ENST00000409789.1	-	9	1250	c.823C>T	c.(823-825)Cgt>Tgt	p.R275C	CNPPD1_ENST00000360507.5_Missense_Mutation_p.R275C			Q9BV87	CNPD1_HUMAN	cyclin Pas1/PHO80 domain containing 1	275					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)	12						AGGAGGCAACGGGAGGTCAGT	0.617000													4	136					0	0	1	0	0
SENP2	59343	broad.mit.edu	37	3	185330413	185330413	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:185330413G>A	ENST00000296257.5	+	9	1076	c.836G>A	c.(835-837)aGg>aAg	p.R279K	SENP2_ENST00000545472.1_Missense_Mutation_p.R269K|SENP2_ENST00000427465.2_Missense_Mutation_p.R103K	NM_021627.2	NP_067640.2	Q9HC62	SENP2_HUMAN	SUMO1/sentrin/SMT3 specific peptidase 2	279					mRNA transport|protein desumoylation|protein transport|proteolysis|regulation of Wnt receptor signaling pathway|transmembrane transport|Wnt receptor signaling pathway	cytoplasm|nuclear membrane|nuclear pore	protein binding|SUMO-specific protease activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(3)	12	all_cancers(143;1.28e-10)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(80;1.31e-21)			GTTGAAACAAGGGGACCTCTA	0.308000													15	13					0	0	1	0	0
ZPLD1	131368	broad.mit.edu	37	3	102181165	102181165	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:102181165G>A	ENST00000306176.1	+	6	771	c.671G>A	c.(670-672)gGa>gAa	p.G224E	ZPLD1_ENST00000491959.1_Missense_Mutation_p.G208E|ZPLD1_ENST00000466937.1_Missense_Mutation_p.G208E	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	208	ZP.					integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						CCCAGTATAGGATTACCTTTG	0.353000													27	46					0	0	1	0	0
TRBV20-1	28567	broad.mit.edu	37	7	142334807	142334807	+	RNA	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:142334807G>A	ENST00000390394.3	+	0	307																											GCAAGGCGTCGAGAAGGACAA	0.517000											OREG0018395	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	45	53					0	0	1	0	0
TECPR1	25851	broad.mit.edu	37	7	97875247	97875247	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:97875247G>A	ENST00000447648.2	-	3	511	c.212C>T	c.(211-213)gCc>gTc	p.A71V	TECPR1_ENST00000542604.1_Intron|TECPR1_ENST00000379795.3_Missense_Mutation_p.A71V			Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	71						integral to membrane	protein binding			central_nervous_system(2)|endometrium(8)|kidney(1)|large_intestine(1)|lung(9)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						ATTCTCATAGGCCTCCTCTCG	0.562000													7	10					0	0	1	0	0
MLXIP	22877	broad.mit.edu	37	12	122618162	122618162	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:122618162C>T	ENST00000319080.6	+	9	1492	c.1360C>T	c.(1360-1362)Cct>Tct	p.P454S	MLXIP_ENST00000538698.1_Missense_Mutation_p.P61S|MLXIP_ENST00000377037.2_Missense_Mutation_p.P44S			Q9HAP2	MLXIP_HUMAN	MLX interacting protein	454					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)	20	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		ACCATTAGTTCCTCCTCCTGC	0.632000													18	17					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56539219	56539219	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:56539219G>A	ENST00000390649.3	+	7	1620	c.1620G>A	c.(1618-1620)tgG>tgA	p.W540*		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	540	NACHT.					mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		AGGGAGTGTGGAATAGGAAGT	0.552000													16	16					0	0	1	0	0
NPFFR2	10886	broad.mit.edu	37	4	72994493	72994493	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr4:72994493G>A	ENST00000308744.6	+	2	589	c.491G>A	c.(490-492)gGa>gAa	p.G164E	NPFFR2_ENST00000358749.3_Missense_Mutation_p.G62E|NPFFR2_ENST00000344413.5_Intron|NPFFR2_ENST00000395999.1_Missense_Mutation_p.G65E	NM_004885.2	NP_004876.2	Q9Y5X5	NPFF2_HUMAN	neuropeptide FF receptor 2	164					detection of abiotic stimulus	actin cytoskeleton|integral to plasma membrane	neuropeptide receptor activity			NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(24)|ovary(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	43			Lung(101;0.0935)|LUSC - Lung squamous cell carcinoma(112;0.138)			TGCATGATGGGAAATACTGTG	0.363000													53	41					0	0	1	0	0
PRPF4B	8899	broad.mit.edu	37	6	4060651	4060651	+	Missense_Mutation	SNP	A	A	C			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr6:4060651A>C	ENST00000337659.6	+	15	2925	c.2825A>C	c.(2824-2826)aAa>aCa	p.K942T	PRPF4B_ENST00000494674.1_3'UTR|PRPF4B_ENST00000538861.1_Missense_Mutation_p.K928T	NM_003913.4	NP_003904.3	Q13523	PRP4B_HUMAN	pre-mRNA processing factor 4B	942	Protein kinase.					catalytic step 2 spliceosome	ATP binding|protein binding|protein serine/threonine kinase activity			breast(6)|endometrium(3)|large_intestine(5)|lung(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	22	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				TTTTAGGAGAAAGTTACTGTT	0.338000													18	22					0	0	1	0	0
MORC1	27136	broad.mit.edu	37	3	108822756	108822756	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:108822756C>T	ENST00000232603.5	-	4	245	c.163G>A	c.(163-165)Gaa>Aaa	p.E55K	MORC1_ENST00000483760.1_Missense_Mutation_p.E55K|MORC1-AS1_ENST00000480826.1_RNA	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	55					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TGCAGTTTTTCATTATCCACT	0.383000													54	61					0	0	1	0	0
FRMD4B	23150	broad.mit.edu	37	3	69237038	69237038	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:69237038C>T	ENST00000542259.1	-	20	2091	c.1640G>A	c.(1639-1641)cGa>cAa	p.R547Q	FRMD4B_ENST00000478263.1_Missense_Mutation_p.R253Q|FRMD4B_ENST00000398540.3_Missense_Mutation_p.R601Q			Q9Y2L6	FRM4B_HUMAN	FERM domain containing 4B	601						cytoplasm|cytoskeleton	binding			NS(2)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(3)|skin(2)	19		Lung NSC(201;0.0138)|Prostate(884;0.11)		BRCA - Breast invasive adenocarcinoma(55;0.000201)|Epithelial(33;0.00141)|LUSC - Lung squamous cell carcinoma(21;0.00999)|Lung(16;0.0182)		TGAACTTGATCGCTGCCCAGG	0.383000													4	5					0	0	1	0	0
CD3G	917	broad.mit.edu	37	11	118220644	118220644	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr11:118220644G>A	ENST00000532917.1	+	3	334	c.266G>A	c.(265-267)gGa>gAa	p.G89E	CD3G_ENST00000532903.1_3'UTR|CD3G_ENST00000392883.2_Missense_Mutation_p.G29E	NM_000073.2	NP_000064.1	P09693	CD3G_HUMAN	CD3g molecule, gamma (CD3-TCR complex)	89	Ig-like.				establishment or maintenance of cell polarity|protein complex assembly|protein transport|regulation of apoptosis|T cell activation|T cell costimulation|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	protein heterodimerization activity|receptor signaling complex scaffold activity|T cell receptor binding|transmembrane receptor activity			breast(2)|kidney(1)|large_intestine(2)|skin(1)	6	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.04e-05)		CAGTGTAAAGGATCACAGAAC	0.388000													22	48					0	0	1	0	0
C2CD3	26005	broad.mit.edu	37	11	73829377	73829377	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr11:73829377G>A	ENST00000334126.7	-	9	1642	c.1416C>T	c.(1414-1416)gtC>gtT	p.V472V	C2CD3_ENST00000313663.7_Silent_p.V472V			Q4AC94	C2CD3_HUMAN	C2 calcium-dependent domain containing 3	472						centrosome				NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(16)|lung(26)|ovary(4)|pancreas(2)|prostate(1)|skin(3)	64	Breast(11;4.16e-06)					TTTTAGAAGGGACGATATCAT	0.423000													21	42					0	0	1	0	0
PRDM2	7799	broad.mit.edu	37	1	14105173	14105173	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:14105173G>A	ENST00000235372.7	+	8	1739	c.883G>A	c.(883-885)Gaa>Aaa	p.E295K	PRDM2_ENST00000311066.5_Missense_Mutation_p.E295K|PRDM2_ENST00000413440.1_Missense_Mutation_p.E94K|PRDM2_ENST00000343137.4_Missense_Mutation_p.E94K|PRDM2_ENST00000376048.5_Intron|PRDM2_ENST00000505823.1_Intron|PRDM2_ENST00000503842.1_Intron	NM_012231.4	NP_036363.2	Q13029	PRDM2_HUMAN	PR domain containing 2, with ZNF domain	295	Asp/Glu-rich (acidic).|Retinoblastoma protein binding.					Golgi apparatus|nucleus	DNA binding|histone-lysine N-methyltransferase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(16)|lung(20)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	55	Ovarian(185;0.249)	all_lung(284;2.56e-05)|Lung NSC(185;4.94e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00224)|Colorectal(212;3.23e-08)|BRCA - Breast invasive adenocarcinoma(304;2.16e-05)|COAD - Colon adenocarcinoma(227;2.53e-05)|Kidney(185;0.000762)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(313;0.00446)|READ - Rectum adenocarcinoma(331;0.0276)|Lung(427;0.145)		cgagggggaagaagaAGCCAG	0.438000													22	25					0	0	1	0	0
NFAT5	10725	broad.mit.edu	37	16	69727950	69727950	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr16:69727950C>T	ENST00000349945.1	+	14	5492	c.3940C>T	c.(3940-3942)Caa>Taa	p.Q1314*	NFAT5_ENST00000354436.2_Nonsense_Mutation_p.Q1390*|NFAT5_ENST00000393742.2_Nonsense_Mutation_p.Q1314*|NFAT5_ENST00000567239.1_Nonsense_Mutation_p.Q1407*|NFAT5_ENST00000566899.1_Nonsense_Mutation_p.Q1314*|NFAT5_ENST00000432919.1_Nonsense_Mutation_p.Q1408*	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	1390					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						CAGTATAAATCAACAAGATAT	0.443000													34	47					0	0	1	0	0
HECW1	23072	broad.mit.edu	37	7	43547627	43547627	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:43547627C>T	ENST00000395891.1	+	23	4368	c.3763C>T	c.(3763-3765)Cgc>Tgc	p.R1255C	HECW1_ENST00000453890.1_Missense_Mutation_p.R1221C	NM_015052.3	NP_055867.3	Q76N89	HECW1_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1	1255					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			NS(2)|breast(10)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(17)|lung(57)|ovary(8)|pancreas(2)|prostate(2)|skin(6)|urinary_tract(3)	125						GCTCATTATTCGCCGGGATCA	0.517000													27	39					0	0	1	0	0
TRAV22	28661	broad.mit.edu	37	14	22539424	22539424	+	RNA	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr14:22539424C>T	ENST00000390450.3	+	0	417																											TTGTACATTTCCTCTTCCCAG	0.527000													15	27					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75974676	75974676	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr15:75974676C>T	ENST00000308508.5	-	8	5000	c.4908G>A	c.(4906-4908)caG>caA	p.Q1636Q		NM_001897.4	NP_001888.2	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4	1636	Cysteine-containing.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						CTGTGCTGTCCTGCTGGGCGT	0.672000													61	46					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128870752	128870752	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:128870752G>A	ENST00000375990.3	+	6	947	c.544G>A	c.(544-546)Gaa>Aaa	p.E182K	UGGT1_ENST00000259253.6_Missense_Mutation_p.E206K			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	206					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TGGCTCTGAGGAATTTTCCAA	0.353000													28	44					0	0	1	0	0
TP63	8626	broad.mit.edu	37	3	189611994	189611994	+	Splice_Site	SNP	G	G	A	rs113056519		TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:189611994G>A	ENST00000264731.3	+	14	1835		c.e14-1		TP63_ENST00000449992.1_Splice_Site|TP63_ENST00000392463.2_Splice_Site|TP63_ENST00000456148.1_Splice_Site|TP63_ENST00000382063.4_Splice_Site|TP63_ENST00000392461.3_Splice_Site|TP63_ENST00000354600.5_Splice_Site|TP63_ENST00000320472.5_Splice_Site|TP63_ENST00000392460.3_Splice_Site|TP63_ENST00000440651.2_Splice_Site	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63						anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		CTGTTGCACAGGATCTGGCAA	0.493000										HNSCC(45;0.13)			32	26					0	0	1	0	0
EPHB2	2048	broad.mit.edu	37	1	23110990	23110990	+	Missense_Mutation	SNP	A	A	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:23110990A>T	ENST00000400191.3	+	3	250	c.232A>T	c.(232-234)Atc>Ttc	p.I78F	EPHB2_ENST00000544305.1_Missense_Mutation_p.I78F|EPHB2_ENST00000374630.3_Missense_Mutation_p.I78F|EPHB2_ENST00000374627.1_Missense_Mutation_p.I72F|EPHB2_ENST00000374632.3_Missense_Mutation_p.I78F	NM_004442.6|NM_017449.3	NP_004433.2|NP_059145.2	P29323	EPHB2_HUMAN	EPH receptor B2	78					axon guidance	integral to plasma membrane	ATP binding|transmembrane-ephrin receptor activity			NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(17)|ovary(4)|pancreas(2)|prostate(3)|skin(8)|stomach(1)|urinary_tract(1)	56		Colorectal(325;3.46e-05)|Lung NSC(340;3.7e-05)|all_lung(284;5.45e-05)|Renal(390;0.000228)|Breast(348;0.0027)|Ovarian(437;0.00327)|Myeloproliferative disorder(586;0.0258)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0348)|OV - Ovarian serous cystadenocarcinoma(117;3.67e-26)|Colorectal(126;3.23e-08)|COAD - Colon adenocarcinoma(152;9.32e-07)|GBM - Glioblastoma multiforme(114;2.93e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000606)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.126)|Lung(427;0.153)		GACCAAGTTTATCCGGCGCCG	0.577000													15	26					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113169455	113169455	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr9:113169455C>T	ENST00000401783.2	-	38	8761	c.8425G>A	c.(8425-8427)Ggc>Agc	p.G2809S	SVEP1_ENST00000374469.1_Missense_Mutation_p.G2786S|SVEP1_ENST00000297826.5_Missense_Mutation_p.G735S	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2809	Sushi 23.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						CTCTCAGTGCCATTCAGCACA	0.488000													90	100					0	0	1	0	0
CADPS2	93664	broad.mit.edu	37	7	122131379	122131379	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:122131379G>A	ENST00000334010.7	-	10	2059	c.1638C>T	c.(1636-1638)acC>acT	p.T546T	CADPS2_ENST00000412584.2_Silent_p.T546T|CADPS2_ENST00000449022.2_Silent_p.T546T|CADPS2_ENST00000313070.7_Silent_p.T546T	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	546	PH.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						GGTGGGGATCGGTATAATCCA	0.368000													6	7					0	0	1	0	0
SLC44A5	204962	broad.mit.edu	37	1	75707705	75707705	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:75707705C>T	ENST00000370855.5	-	9	626	c.513G>A	c.(511-513)gcG>gcA	p.A171A	SLC44A5_ENST00000370859.3_Silent_p.A171A|SLC44A5_ENST00000535611.1_Silent_p.A41A	NM_152697.4	NP_689910.2	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5	171						integral to membrane|plasma membrane	choline transmembrane transporter activity			kidney(1)|large_intestine(13)|lung(35)|ovary(2)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	61						TGGGAAAAATCGCTGTTGGAC	0.353000													18	54					0	0	1	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156634459	156634459	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr4:156634459G>A	ENST00000296518.7	+	7	1505	c.1296G>A	c.(1294-1296)ctG>ctA	p.L432L	GUCY1A3_ENST00000511108.1_Silent_p.L432L|GUCY1A3_ENST00000506455.1_Silent_p.L432L|GUCY1A3_ENST00000393832.3_Silent_p.L174L|GUCY1A3_ENST00000513574.1_Silent_p.L432L|GUCY1A3_ENST00000511507.1_Silent_p.L432L|GUCY1A3_ENST00000455639.2_Silent_p.L432L			Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3	432					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|liver(2)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		TGGGGAAGCTGAAGGCTACCC	0.527000													19	15					0	0	1	0	0
C16orf62	57020	broad.mit.edu	37	16	19580814	19580814	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr16:19580814C>T	ENST00000438132.3	+	3	501	c.453C>T	c.(451-453)tcC>tcT	p.S151S	C16orf62_ENST00000542263.1_Silent_p.S151S|C16orf62_ENST00000417362.2_Silent_p.S62S|C16orf62_ENST00000251143.5_Silent_p.S62S|C16orf62_ENST00000538853.1_Silent_p.S151S	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	62						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						CCTCCTCCTCCAGCTCCGTGG	0.567000													39	53					0	0	1	0	0
ZFP64	55734	broad.mit.edu	37	20	50769633	50769633	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr20:50769633G>A	ENST00000216923.4	-	6	1447	c.1098C>T	c.(1096-1098)tgC>tgT	p.C366C	ZFP64_ENST00000371518.2_Intron|ZFP64_ENST00000361387.2_Intron|ZFP64_ENST00000371515.4_Silent_p.C364C|ZFP64_ENST00000477786.1_Intron|ZFP64_ENST00000346617.4_Silent_p.C312C	NM_018197.2|NM_199426.1	NP_060667.2|NP_955458.1	Q9NPA5	ZF64A_HUMAN	ZFP64 zinc finger protein	366					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|endometrium(5)|large_intestine(8)|lung(11)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	33						GGCGGTCGGTGCAGTGGATAC	0.577000													73	78					0	0	1	0	0
TRIML2	205860	broad.mit.edu	37	4	189012721	189012721	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr4:189012721G>A	ENST00000512729.1	-	7	1344	c.970C>T	c.(970-972)Ctt>Ttt	p.L324F	TRIML2_ENST00000326754.3_Missense_Mutation_p.L349F	NM_173553.1	NP_775824.1	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	324	B30.2/SPRY.						ligase activity			central_nervous_system(2)|kidney(1)|large_intestine(7)|lung(25)|prostate(3)|urinary_tract(1)	39		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		TCGCAGTCAAGGAAAACGCCA	0.532000													41	105					0	0	1	0	0
KLF5	688	broad.mit.edu	37	13	73636330	73636330	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr13:73636330C>T	ENST00000377687.4	+	2	1129	c.593C>T	c.(592-594)aCc>aTc	p.T198I	KLF5_ENST00000539231.1_Missense_Mutation_p.T107I|KLF5_ENST00000477333.1_3'UTR	NM_001730.3	NP_001721.2	Q13887	KLF5_HUMAN	Kruppel-like factor 5 (intestinal)	198					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		TCACACCAGACCGCAGCTCCA	0.537000													50	41					0	0	1	0	0
CYTIP	9595	broad.mit.edu	37	2	158272404	158272404	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:158272404C>T	ENST00000264192.3	-	8	986	c.865G>A	c.(865-867)Gag>Aag	p.E289K	CYTIP_ENST00000540637.1_Missense_Mutation_p.E183K	NM_004288.4	NP_004279.3	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	289	Ser-rich.				regulation of cell adhesion	cell cortex|early endosome	protein binding			breast(2)|central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|skin(2)	15						TCATCCCCCTCCTTGGGGATA	0.542000													37	48					0	0	1	0	0
OR1L6	392390	broad.mit.edu	37	9	125513035	125513035	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr9:125513035G>A	ENST00000373684.1	+	1	1017	c.1017G>A	c.(1015-1017)aaG>aaA	p.K339K	OR1L6_ENST00000304720.2_Silent_p.K303K			Q8NGR2	OR1L6_HUMAN	olfactory receptor, family 1, subfamily L, member 6	339					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|large_intestine(5)|lung(4)|ovary(1)|stomach(1)	12						GGGGTTTGAAGAAATTACAGG	0.403000													37	28					0	0	1	0	0
WFDC11	259239	broad.mit.edu	37	20	44278037	44278037	+	Splice_Site	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr20:44278037C>T	ENST00000356562.2	-	4	323	c.100_splice	c.e4-1	p.R34_splice	WFDC11_ENST00000324384.3_Splice_Site_p.R34_splice			Q8NEX6	WFD11_HUMAN	WAP four-disulfide core domain 11	34						extracellular region				endometrium(1)|lung(4)	5		Myeloproliferative disorder(115;0.0122)				ACAATTCCTTCCCTGAAATTG	0.388000													54	72					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74091511	74091511	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr18:74091511G>A	ENST00000443185.2	-	4	2876	c.2559C>T	c.(2557-2559)ccC>ccT	p.P853P	ZNF516_ENST00000524431.2_5'UTR	NM_014643.3	NP_055458.1	Q92618	ZN516_HUMAN	zinc finger protein 516	853					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CCACTCCCAGGGGAGAAGAGC	0.627000													47	81					0	0	1	0	0
C3P1	388503	broad.mit.edu	37	19	10165989	10165989	+	RNA	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:10165989G>A	ENST00000495140.1	+	0	1617																				endometrium(4)|large_intestine(2)|lung(6)|urinary_tract(1)	13						GGGAACCCAGGAAGCACTTGG	0.607000													31	58					0	0	1	0	0
CPXM2	119587	broad.mit.edu	37	10	125557523	125557523	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:125557523C>T	ENST00000241305.3	-	6	1012	c.858G>A	c.(856-858)atG>atA	p.M286I	CPXM2_ENST00000368854.3_5'UTR	NM_198148.2	NP_937791.2	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	286	F5/8 type C.				cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(7)|kidney(2)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)	47		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		TCTCCATTCTCATGCAGATGC	0.557000													30	22					0	0	1	0	0
RFT1	91869	broad.mit.edu	37	3	53155759	53155759	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:53155759G>A	ENST00000296292.3	-	5	575	c.514C>T	c.(514-516)Ctg>Ttg	p.L172L	RFT1_ENST00000394738.3_Silent_p.L133L	NM_052859.3	NP_443091.1	Q96AA3	RFT1_HUMAN	RFT1 homolog (S. cerevisiae)	172					carbohydrate transport|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane	lipid transporter activity			NS(1)|breast(1)|kidney(1)|lung(5)|skin(2)|urinary_tract(2)	12				BRCA - Breast invasive adenocarcinoma(193;6.98e-05)|Kidney(197;0.0017)|KIRC - Kidney renal clear cell carcinoma(197;0.00192)|OV - Ovarian serous cystadenocarcinoma(275;0.104)		GGCAACCACAGCACGAGAAAA	0.408000													12	20					0	0	1	0	0
HIVEP2	3097	broad.mit.edu	37	6	143091612	143091612	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr6:143091612G>A	ENST00000367603.2	-	5	5006	c.4264C>T	c.(4264-4266)Ccc>Tcc	p.P1422S	HIVEP2_ENST00000012134.2_Missense_Mutation_p.P1422S|HIVEP2_ENST00000367604.1_Missense_Mutation_p.P1422S	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	1422					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		AAACACAAGGGGATGGAGGAT	0.547000													27	42					0	0	1	0	0
UGGT1	56886	broad.mit.edu	37	2	128870751	128870751	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:128870751G>A	ENST00000375990.3	+	6	946	c.543G>A	c.(541-543)gaG>gaA	p.E181E	UGGT1_ENST00000259253.6_Silent_p.E205E			Q9NYU2	UGGG1_HUMAN	UDP-glucose glycoprotein glucosyltransferase 1	205					'de novo' posttranslational protein folding|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity|unfolded protein binding			NS(1)|breast(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(14)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TTGGCTCTGAGGAATTTTCCA	0.353000													30	45					0	0	1	0	0
ZNF233	353355	broad.mit.edu	37	19	44770458	44770458	+	Nonsense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:44770458C>T	ENST00000334152.1	+	4	475	c.475C>T	c.(475-477)Cag>Tag	p.Q159*	ZNF233_ENST00000592581.1_Silent_p.F41F|ZNF233_ENST00000391958.2_Silent_p.F41F|ZNF233_ENST00000589522.1_Silent_p.F41F|ZNF235_ENST00000589799.1_Intron			A6NK53	ZN233_HUMAN	zinc finger protein 233	0					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(4)|skin(3)|urinary_tract(1)	20		Prostate(69;0.0435)|all_neural(266;0.226)				TGGAGAACTTCAGGAACCTGC	0.507000													72	97					0	0	1	0	0
RAPGEF3	10411	broad.mit.edu	37	12	48137388	48137388	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:48137388C>T	ENST00000405493.2	-	18	1833	c.1624G>A	c.(1624-1626)Gag>Aag	p.E542K	RAPGEF3_ENST00000389212.3_Missense_Mutation_p.E584K|RAPGEF3_ENST00000449771.2_Missense_Mutation_p.E584K|RAPGEF3_ENST00000171000.4_Missense_Mutation_p.E542K|RAPGEF3_ENST00000549151.1_Missense_Mutation_p.E542K|RAPGEF3_ENST00000548919.1_Intron	NM_001098532.2|NM_006105.5	NP_001092002.1|NP_006096.2	A8K2G5	A8K2G5_HUMAN	Rap guanine nucleotide exchange factor (GEF) 3	542					regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex	cAMP-dependent protein kinase regulator activity|guanyl-nucleotide exchange factor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(9)|pancreas(1)|prostate(1)|skin(7)	25	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.0375)		GCCATCACCTCTCTCACGGAG	0.607000													42	64					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1652489	1652489	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:1652489G>A	ENST00000252804.4	-	17	3113	c.3063C>T	c.(3061-3063)atC>atT	p.I1021I		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	1021					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CCGCACCCACGATCTTCCTGG	0.617000													15	8					0	0	1	0	0
TSPAN8	7103	broad.mit.edu	37	12	71531935	71531935	+	Splice_Site	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:71531935C>T	ENST00000393330.2	-	8	889		c.e8+1		TSPAN8_ENST00000247829.3_Splice_Site|TSPAN8_ENST00000546561.1_Splice_Site|TSPAN8_ENST00000552128.1_Splice_Site			P19075	TSN8_HUMAN	tetraspanin 8						protein glycosylation	integral to membrane|lysosome	signal transducer activity			breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(3)|lung(7)|skin(3)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			TGTGCACACACCTTAGATTTG	0.358000													72	101					0	0	1	0	0
ZNF710	374655	broad.mit.edu	37	15	90611620	90611620	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr15:90611620C>T	ENST00000268154.4	+	2	1502	c.1251C>T	c.(1249-1251)tcC>tcT	p.S417S		NM_198526.2	NP_940928.2	Q8N1W2	ZN710_HUMAN	zinc finger protein 710	417					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(4)|lung(1)|ovary(2)|prostate(1)|stomach(1)|urinary_tract(3)	19	Melanoma(11;0.00551)|Lung NSC(78;0.0196)|all_lung(78;0.04)		BRCA - Breast invasive adenocarcinoma(143;0.00769)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.129)			TGGACTTCTCCACCCTGACCC	0.662000													35	33					0	0	1	0	0
ATRAID	51374	broad.mit.edu	37	2	27438360	27438360	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:27438360C>T	ENST00000380171.3	+	4	654	c.477C>T	c.(475-477)ccC>ccT	p.P159P	ATRAID_ENST00000405489.3_Silent_p.P46P|ATRAID_ENST00000606999.1_Silent_p.P104P	NM_080592.3	NP_542159.3			all-trans retinoic acid-induced differentiation factor																		AAGCAAACCCCCTCAAAGGTG	0.468000													65	59					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101295476	101295476	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:101295476G>A	ENST00000538618.1	+	4	411	c.411G>A	c.(409-411)cgG>cgA	p.R137R	ANO4_ENST00000299222.9_5'UTR|ANO4_ENST00000392979.3_5'UTR|ANO4_ENST00000392977.3_5'UTR			Q32M45	ANO4_HUMAN	anoctamin 4	0						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TCCATCAACGGCGAAGTGTGG	0.498000										HNSCC(74;0.22)			28	25					0	0	1	0	0
CEACAM3	1084	broad.mit.edu	37	19	42301621	42301621	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:42301621C>T	ENST00000357396.3	+	2	406	c.165C>T	c.(163-165)gtC>gtT	p.V55V	CEACAM3_ENST00000595255.1_3'UTR|CEACAM3_ENST00000344550.4_Silent_p.V55V|CEACAM3_ENST00000221999.4_Silent_p.V55V	NM_001815.2	NP_001806.2	P40198	CEAM3_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 3	55	Ig-like V-type.					integral to membrane				endometrium(2)|kidney(4)|large_intestine(1)|lung(4)|prostate(3)|skin(4)|stomach(1)	19						TTCTACTTGTCCACAATCTGC	0.493000													89	96					0	0	1	0	0
UBR2	23304	broad.mit.edu	37	6	42603282	42603282	+	Missense_Mutation	SNP	G	G	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr6:42603282G>T	ENST00000372901.1	+	14	1930	c.1672G>T	c.(1672-1674)Gat>Tat	p.D558Y	UBR2_ENST00000372899.1_Missense_Mutation_p.D558Y|UBR2_ENST00000372883.3_Missense_Mutation_p.D62Y			Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	558					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			GTGTGCTTCAGATGTGAGTTT	0.423000													62	60					4.79706e-38	4.89471e-38	1	1	0
MPC2	25874	broad.mit.edu	37	1	167887567	167887567	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:167887567G>A	ENST00000367846.4	-	5	576	c.378C>T	c.(376-378)caC>caT	p.H126H	MPC2_ENST00000271373.4_Silent_p.H126H	NM_015415.3	NP_056230.1			mitochondrial pyruvate carrier 2																		TCTTTTATTTGTGTGCTTTAG	0.308000													19	18					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110457059	110457059	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr8:110457059G>A	ENST00000378402.5	+	38	5065	c.4961G>A	c.(4960-4962)cGa>cAa	p.R1654Q		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1654					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			TTTGATAGGCGATTTGTACTT	0.433000										HNSCC(38;0.096)			112	125					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	216348630	216348630	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:216348630G>A	ENST00000366943.2	-	21	4977	c.4591C>T	c.(4591-4593)Ccc>Tcc	p.P1531S	USH2A_ENST00000307340.3_Missense_Mutation_p.P1531S|USH2A_ENST00000366942.3_Missense_Mutation_p.P1531S			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1531	Laminin G-like 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		GTGGAGCTGGGAAATTTACAA	0.403000										HNSCC(13;0.011)			14	18					0	0	1	0	0
DCAF4L2	138009	broad.mit.edu	37	8	88885791	88885791	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr8:88885791G>A	ENST00000319675.3	-	1	505	c.409C>T	c.(409-411)Cac>Tac	p.H137Y		NM_152418.3	NP_689631.1	Q8NA75	DC4L2_HUMAN	DDB1 and CUL4 associated factor 4-like 2	137										breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(19)|liver(2)|lung(40)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	83						GAATCCAAGTGATTCAGTGAG	0.567000													62	58					0	0	1	0	0
TPTE	7179	broad.mit.edu	37	21	10914420	10914420	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr21:10914420G>A	ENST00000298232.7	-	20	1612	c.1245C>T	c.(1243-1245)atC>atT	p.I415I	TPTE_ENST00000415664.2_5'UTR|TPTE_ENST00000361285.4_Silent_p.I433I|TPTE_ENST00000342420.5_Silent_p.I395I	NM_199259.2	NP_954868.1	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	433	C2 tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(19)|lung(76)|ovary(2)|prostate(2)|skin(8)|urinary_tract(1)	130			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTTCTATTTGGATTTTTAGAT	0.313000													5	30					0	0	1	0	0
CXCR4	7852	broad.mit.edu	37	2	136873442	136873442	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:136873442C>T	ENST00000409817.1	-	1	371	c.68G>A	c.(67-69)gGg>gAg	p.G23E	CXCR4_ENST00000466288.1_5'UTR|CXCR4_ENST00000241393.3_Missense_Mutation_p.G19E	NM_001008540.1	NP_001008540.1	P61073	CXCR4_HUMAN	chemokine (C-X-C motif) receptor 4	19					activation of MAPK activity|apoptosis|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|inflammatory response|initiation of viral infection|regulation of chemotaxis|response to hypoxia|response to virus	cell leading edge|cell surface|cytoplasmic membrane-bounded vesicle|integral to membrane|plasma membrane	actin binding|C-X-C chemokine receptor activity|coreceptor activity|myosin light chain binding|ubiquitin binding|ubiquitin protein ligase binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(14)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.155)	Framycetin(DB00452)	GTCATAGTCCCCTGAGCCCAT	0.423000													54	50					0	0	1	0	0
PHF6	84295	broad.mit.edu	37	X	133551267	133551267	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chrX:133551267C>T	ENST00000332070.3	+	9	1105	c.903C>T	c.(901-903)taC>taT	p.Y301Y	PHF6_ENST00000370803.3_Silent_p.Y301Y|PHF6_ENST00000416404.2_Silent_p.Y267Y|PHF6_ENST00000394292.1_Silent_p.Y302Y|PHF6_ENST00000370799.1_Silent_p.Y302Y	NM_032458.2	NP_115834.1	Q8IWS0	PHF6_HUMAN	PHD finger protein 6	301					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	zinc ion binding	p.Y301fs*1(1)|p.Y301*(1)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(88)|kidney(2)|large_intestine(1)|liver(1)|lung(6)|ovary(1)|skin(1)|urinary_tract(1)	103	Acute lymphoblastic leukemia(192;0.000127)					TTAAGACTTACCATTACCACT	0.358000			"""F, N, Splice, Mis"""		ETP ALL								32	0					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179587872	179587872	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:179587872C>T	ENST00000589042.1	-	75	22086	c.21862G>A	c.(21862-21864)Gaa>Aaa	p.E7288K	TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.E6971K|TTN_ENST00000342992.6_Missense_Mutation_p.E6044K|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	6971							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAGAATTTCCAGGATACAA	0.393000													6	11					0	0	1	0	0
SIGLEC8	27181	broad.mit.edu	37	19	51961464	51961464	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:51961464C>T	ENST00000321424.3	-	1	244	c.178G>A	c.(178-180)Gac>Aac	p.D60N	SIGLEC8_ENST00000340550.5_Missense_Mutation_p.D60N|SIGLEC8_ENST00000430817.1_Missense_Mutation_p.D60N	NM_014442.2	NP_055257.2	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8	60	Ig-like V-type.				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			NS(1)|central_nervous_system(3)|endometrium(2)|kidney(4)|large_intestine(11)|liver(3)|lung(15)|ovary(2)|skin(4)|stomach(3)|urinary_tract(2)	50		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TGAACTGGGTCAGAGTCAGTC	0.587000													54	68					0	0	1	0	0
C5	727	broad.mit.edu	37	9	123751988	123751988	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr9:123751988G>A	ENST00000223642.1	-	24	3041	c.3012C>T	c.(3010-3012)ccC>ccT	p.P1004P		NM_001735.2	NP_001726.2	P01031	CO5_HUMAN	complement component 5	1004					activation of MAPK activity|chemotaxis|complement activation, alternative pathway|complement activation, classical pathway|cytolysis|G-protein coupled receptor protein signaling pathway|inflammatory response|negative regulation of macrophage chemotaxis|positive regulation of chemokine secretion|positive regulation vascular endothelial growth factor production	extracellular space|membrane attack complex	chemokine activity|endopeptidase inhibitor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(14)|lung(5)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	46				OV - Ovarian serous cystadenocarcinoma(323;4.98e-53)|GBM - Glioblastoma multiforme(294;0.0242)	Eculizumab(DB01257)	CACTCCCTTTGGGGAGGTGGG	0.438000													31	76					0	0	1	0	0
OR4N5	390437	broad.mit.edu	37	14	20612737	20612737	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr14:20612737G>A	ENST00000333629.1	+	1	843	c.843G>A	c.(841-843)ttG>ttA	p.L281L		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		TCTTTCCTTTGATGAACCCTG	0.408000													52	50					0	0	1	0	0
USH2A	7399	broad.mit.edu	37	1	215844436	215844436	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:215844436C>T	ENST00000366943.2	-	64	14397	c.14011G>A	c.(14011-14013)Gaa>Aaa	p.E4671K	USH2A_ENST00000307340.3_Missense_Mutation_p.E4671K			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	4671	Fibronectin type-III 32.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTGTATAATTCGTAATACAAA	0.418000										HNSCC(13;0.011)			33	45					0	0	1	0	0
PPP6C	5537	broad.mit.edu	37	9	127911958	127911958	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr9:127911958G>A	ENST00000451402.1	-	8	1243	c.1023C>T	c.(1021-1023)ttC>ttT	p.F341F	PPP6C_ENST00000373546.3_Silent_p.F157F|PPP6C_ENST00000373547.4_Silent_p.F304F|PPP6C_ENST00000415905.1_Silent_p.F282F	NM_001123355.1	NP_001116827.1	O00743	PPP6_HUMAN	protein phosphatase 6, catalytic subunit	304					G1/S transition of mitotic cell cycle|protein dephosphorylation	cytosol	metal ion binding|protein binding|protein serine/threonine phosphatase activity			NS(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(2)|ovary(1)|skin(3)	14						GGCCTCAAAGGAAATATGGCG	0.418000													35	82					0	0	1	0	0
ELANE	1991	broad.mit.edu	37	19	856086	856086	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:856086C>T	ENST00000590230.1	+	6	867	c.726C>T	c.(724-726)atC>atT	p.I242I	ELANE_ENST00000263621.1_Silent_p.I242I			P08246	ELNE_HUMAN	elastase, neutrophil expressed	242	Peptidase S1.				cellular calcium ion homeostasis|negative regulation of chemokine biosynthetic process|negative regulation of chemotaxis|negative regulation of inflammatory response|negative regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of MAP kinase activity|positive regulation of smooth muscle cell proliferation|protein catabolic process|proteolysis|response to UV	cell surface|extracellular region|stored secretory granule	bacterial cell surface binding|cytokine binding|heparin binding			breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(4)|large_intestine(1)|lung(4)|pancreas(1)	13					Alpha-1-proteinase inhibitor(DB00058)|Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TAAACTGGATCGACTCTATCA	0.652000													138	175					0	0	1	0	0
ZAN	7455	broad.mit.edu	37	7	100336192	100336192	+	RNA	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:100336192G>A	ENST00000542585.1	+	0	870				ZAN_ENST00000546292.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000421100.1_RNA|ZAN_ENST00000538115.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000443370.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			GGGTCATCAGGAAAGCCAGGC	0.557000													11	16					0	0	1	0	0
TRPC7	57113	broad.mit.edu	37	5	135601998	135601998	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:135601998C>T	ENST00000513104.1	-	5	1537	c.1255G>A	c.(1255-1257)Gaa>Aaa	p.E419K	TRPC7_ENST00000355180.3_Missense_Mutation_p.E358K|TRPC7_ENST00000426057.2_Missense_Mutation_p.E303K	NM_020389.2	NP_065122.1	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel, subfamily C, member 7	419					axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding			NS(1)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(3)	46			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GTGAAGGTTTCGTTTGGCAGG	0.398000													49	3					0	0	1	0	0
FGA	2243	broad.mit.edu	37	4	155506994	155506994	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr4:155506994G>A	ENST00000302053.3	-	5	1665	c.1587C>T	c.(1585-1587)ttC>ttT	p.F529F	FGA_ENST00000403106.3_Silent_p.F529F	NM_000508.3	NP_000499.1	P02671	FIBA_HUMAN	fibrinogen alpha chain	529					platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(14)|liver(2)|lung(20)|ovary(3)|pancreas(1)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(6)	73	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	AGAAACCTGGGAATGTTTTTC	0.473000													29	12					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121219325	121219325	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr8:121219325C>T	ENST00000297848.3	+	10	1453	c.1183C>T	c.(1183-1185)Cca>Tca	p.P395S	COL14A1_ENST00000309791.4_Missense_Mutation_p.P395S|COL14A1_ENST00000247781.3_Missense_Mutation_p.P300S|COL14A1_ENST00000537875.1_Missense_Mutation_p.P395S|COL14A1_ENST00000432943.2_3'UTR	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	395	Fibronectin type-III 2.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GGGTGGAAAACCAGACGAGGT	0.373000													11	14					0	0	1	0	0
ALDH1A2	8854	broad.mit.edu	37	15	58302906	58302906	+	Missense_Mutation	SNP	T	T	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr15:58302906T>A	ENST00000249750.4	-	4	1201	c.434A>T	c.(433-435)aAa>aTa	p.K145I	ALDH1A2_ENST00000559517.1_Missense_Mutation_p.K49I|ALDH1A2_ENST00000537372.1_Missense_Mutation_p.K124I|ALDH1A2_ENST00000558231.1_Missense_Mutation_p.K116I|ALDH1A2_ENST00000347587.3_Missense_Mutation_p.K145I	NM_003888.3	NP_003879.2	O94788	AL1A2_HUMAN	aldehyde dehydrogenase 1 family, member A2	145					negative regulation of cell proliferation|neural tube development|response to cytokine stimulus	nucleus	3-chloroallyl aldehyde dehydrogenase activity|retinal binding|retinal dehydrogenase activity			NS(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(15)|prostate(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(80;0.152)|all cancers(107;0.18)	NADH(DB00157)|Tretinoin(DB00755)|Vitamin A(DB00162)	TCGAAAGGTTTTGATGACGCC	0.423000													13	15					0	0	1	0	0
RELN	5649	broad.mit.edu	37	7	103338452	103338452	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr7:103338452C>T	ENST00000428762.1	-	10	1150	c.991G>A	c.(991-993)Gaa>Aaa	p.E331K	RELN_ENST00000343529.5_Missense_Mutation_p.E331K|RELN_ENST00000424685.2_Missense_Mutation_p.E331K	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	331					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity	p.E331K(2)		NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		CGAAGATTTTCCTGCTTCCAC	0.448000													64	69					0	0	1	0	0
TENM4	26011	broad.mit.edu	37	11	78449574	78449574	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr11:78449574C>T	ENST00000278550.7	-	20	3260	c.2798G>A	c.(2797-2799)gGa>gAa	p.G933E		NM_001098816.2	NP_001092286.2			teneurin transmembrane protein 4																		CAGGGGGGTTCCATCTGATGT	0.473000													23	15					0	0	1	0	0
IGHV3-7	28452	broad.mit.edu	37	14	106518643	106518643	+	RNA	SNP	G	G	A	rs113025074		TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr14:106518643G>A	ENST00000390598.2	-	0	186																											AGAGTCTCAGGGACCCCCCAG	0.597000													96	116					0	0	1	0	0
LBP	3929	broad.mit.edu	37	20	36992676	36992676	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr20:36992676G>A	ENST00000217407.2	+	7	861	c.700G>A	c.(700-702)Gaa>Aaa	p.E234K		NM_004139.3	NP_004130.2	P18428	LBP_HUMAN	lipopolysaccharide binding protein	234					acute-phase response|cellular defense response|cellular response to lipoteichoic acid|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|detection of molecule of bacterial origin|innate immune response|lipid transport|lipopolysaccharide transport|lipopolysaccharide-mediated signaling pathway|macrophage activation involved in immune response|negative regulation of tumor necrosis factor production|opsonization|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of macrophage activation|positive regulation of respiratory burst involved in inflammatory response|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of tumor necrosis factor production|Toll signaling pathway	extracellular space	Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|lipid binding|lipopolysaccharide binding|lipoteichoic acid binding|receptor binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(2)|lung(16)|ovary(2)|prostate(1)|urinary_tract(1)	28		Myeloproliferative disorder(115;0.00878)				TAGCTTAGTGGAAGCCCCTCG	0.547000													35	39					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179392412	179392412	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:179392412C>T	ENST00000589042.1	-	362	107665	c.107441G>A	c.(107440-107442)gGa>gAa	p.G35814E	TTN-AS1_ENST00000585625.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000419746.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.G26874E|TTN_ENST00000342175.6_Missense_Mutation_p.G26941E|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000587568.1_RNA|TTN-AS1_ENST00000592630.1_RNA|TTN-AS1_ENST00000604571.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN_ENST00000591111.1_Missense_Mutation_p.G34173E|TTN-AS1_ENST00000589434.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN_ENST00000342992.6_Missense_Mutation_p.G33246E|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Missense_Mutation_p.G26749E	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	34173							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CGAGAAGCTTCCTTGCAAGCT	0.483000													10	17					0	0	1	0	0
PARP6	56965	broad.mit.edu	37	15	72549781	72549781	+	Splice_Site	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr15:72549781G>A	ENST00000569795.1	-	13	1594	c.906_splice	c.e13-1	p.P303_splice	PARP6_ENST00000287196.9_Splice_Site_p.P303_splice|PARP6_ENST00000260376.7_Splice_Site_p.P303_splice|PARP6_ENST00000413097.2_5'UTR			Q2NL67	PARP6_HUMAN	poly (ADP-ribose) polymerase family, member 6	303							NAD+ ADP-ribosyltransferase activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(8)|skin(1)|urinary_tract(1)	18						CAGACAGCTGGCTGAAAGGAT	0.512000													31	67					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9085830	9085830	+	Silent	SNP	A	A	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:9085830A>T	ENST00000397910.4	-	1	6188	c.5985T>A	c.(5983-5985)gtT>gtA	p.V1995V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1995	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TCTGCACAGAAACTTTTTCTG	0.468000													30	37					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179615343	179615343	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:179615343C>T	ENST00000360870.5	-	46	12006	c.11784G>A	c.(11782-11784)atG>atA	p.M3928I	TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000591111.1_Intron|TTN_ENST00000589042.1_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_133379.3	NP_596870.2	Q8WZ42	TITIN_HUMAN	titin	9748							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAAAAATCTCATGTTTTCTT	0.343000													4	9					0	0	1	0	0
XDH	7498	broad.mit.edu	37	2	31609293	31609293	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:31609293C>T	ENST00000379416.3	-	9	828	c.780G>A	c.(778-780)ggG>ggA	p.G260G	XDH_ENST00000491727.1_5'UTR	NM_000379.3	NP_000370.2	P47989	XDH_HUMAN	xanthine dehydrogenase	260	FAD-binding PCMH-type.				purine nucleotide catabolic process|xanthine catabolic process	cytosol|extracellular region|peroxisome	2 iron, 2 sulfur cluster binding|electron carrier activity|flavin adenine dinucleotide binding|iron ion binding|molybdopterin cofactor binding|protein homodimerization activity|xanthine dehydrogenase activity|xanthine oxidase activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(31)|ovary(1)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(1)	74	Acute lymphoblastic leukemia(172;0.155)				Allopurinol(DB00437)|Carvedilol(DB01136)|Daunorubicin(DB00694)|Deferoxamine(DB00746)|Desflurane(DB01189)|Menadione(DB00170)|Mercaptopurine(DB01033)|Methotrexate(DB00563)|NADH(DB00157)|Nitrofurazone(DB00336)|Papaverine(DB01113)|Procarbazine(DB01168)|Pyrazinamide(DB00339)|Rasburicase(DB00049)|Spermine(DB00127)|Trifluoperazine(DB00831)|Vitamin E(DB00163)	TCTCCGTGTTCCCCACGACCA	0.627000													34	44					0	0	1	0	0
POMT1	10585	broad.mit.edu	37	9	134384356	134384356	+	Missense_Mutation	SNP	C	C	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr9:134384356C>A	ENST00000423007.1	+	6	928	c.486C>A	c.(484-486)ttC>ttA	p.F162L	POMT1_ENST00000372228.3_Missense_Mutation_p.F162L|POMT1_ENST00000354713.4_Missense_Mutation_p.F132L|POMT1_ENST00000541219.1_Intron|POMT1_ENST00000341012.7_Missense_Mutation_p.F108L|POMT1_ENST00000404875.2_Missense_Mutation_p.F45L|POMT1_ENST00000402686.3_Missense_Mutation_p.F162L|POMT1_ENST00000419118.2_Missense_Mutation_p.F10L	NM_001136113.1	NP_001129585.1	Q9Y6A1	POMT1_HUMAN	protein-O-mannosyltransferase 1	162					multicellular organismal development|protein O-linked glycosylation	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate-mannose-protein mannosyltransferase activity|metal ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	31		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;2.65e-05)|Epithelial(140;0.000259)		TAATATTTTTCAATCTATTGG	0.393000													33	3					2.1956e-27	2.22895e-27	1	1	0
DPAGT1	1798	broad.mit.edu	37	11	118969160	118969160	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr11:118969160G>A	ENST00000409993.2	-	7	2232	c.681C>T	c.(679-681)ttC>ttT	p.F227F	DPAGT1_ENST00000432443.2_Silent_p.F120F|DPAGT1_ENST00000354202.4_Silent_p.F227F			Q9H3H5	GPT_HUMAN	dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)	227					dolichol biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|protein oligomerization	integral to endoplasmic reticulum membrane|microsome	phospho-N-acetylmuramoyl-pentapeptide-transferase activity|transferase activity, transferring glycosyl groups|UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity	p.F227F(1)		breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(2)	17	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.55e-05)		AGGGTATCATGAAGTAGAGGG	0.443000													30	58					0	0	1	0	0
PCMTD1	115294	broad.mit.edu	37	8	52732986	52732986	+	Silent	SNP	T	T	C			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr8:52732986T>C	ENST00000360540.5	-	7	1405	c.999A>G	c.(997-999)ttA>ttG	p.L333L	PCMTD1_ENST00000519559.1_5'UTR|PCMTD1_ENST00000544451.1_Silent_p.L257L|PCMTD1_ENST00000522514.1_Silent_p.L333L	NM_052937.2	NP_443169.2	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	333						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity			NS(2)|endometrium(1)|kidney(3)|large_intestine(3)|lung(17)|prostate(2)|skin(8)|soft_tissue(1)	37		Lung NSC(129;0.0795)|all_lung(136;0.144)				TTTCTCTCAGTAAATTTTGAG	0.363000													3	46					0	0	1	0	0
GOLGA2P5	55592	broad.mit.edu	37	12	100550533	100550533	+	RNA	SNP	G	G	C			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:100550533G>C	ENST00000397112.4	-	0	2288					NR_036632.1															large_intestine(1)|lung(3)	4						TGCTCAGTGGGGTTGTCACAG	0.562000													5	8					0	0	1	0	0
PAK7	57144	broad.mit.edu	37	20	9561263	9561263	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr20:9561263C>T	ENST00000378429.3	-	5	1065	c.519G>A	c.(517-519)atG>atA	p.M173I	PAK7_ENST00000353224.5_Missense_Mutation_p.M173I|PAK7_ENST00000378423.1_Missense_Mutation_p.M173I	NM_020341.3	NP_065074.1	Q9P286	PAK7_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 7	173	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(44)|ovary(2)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)	81			COAD - Colon adenocarcinoma(9;0.194)			GCTTCATTTTCATTACGTGCC	0.463000													73	78					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	140992371	140992371	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:140992371C>T	ENST00000389484.3	-	90	14614	c.13643G>A	c.(13642-13644)gGa>gAa	p.G4548E		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4548					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		agttagtggtcctttcaaatc	0.443000										TSP Lung(27;0.18)			9	21					0	0	1	0	0
MROH2B	133558	broad.mit.edu	37	5	41052626	41052626	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:41052626C>T	ENST00000399564.4	-	12	1621	c.1171G>A	c.(1171-1173)Gaa>Aaa	p.E391K	MROH2B_ENST00000506092.2_Intron	NM_173489.4	NP_775760.3			maestro heat-like repeat family member 2B																		GGCCATCCTTCCCGAGCTTCA	0.393000													26	32					0	0	1	0	0
DSCAM	1826	broad.mit.edu	37	21	41725546	41725546	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr21:41725546C>T	ENST00000400454.1	-	5	1257	c.780G>A	c.(778-780)aaG>aaA	p.K260K		NM_001389.3	NP_001380.2	O60469	DSCAM_HUMAN	Down syndrome cell adhesion molecule	260	Ig-like C2-type 3.				cell adhesion|dendrite self-avoidance|negative regulation of cell adhesion|positive regulation of axon extension involved in axon guidance|positive regulation of phosphorylation	axon|extracellular region|growth cone|integral to plasma membrane|membrane fraction	protein binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(22)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(22)|lung(47)|ovary(7)|pancreas(2)|prostate(3)|skin(14)|upper_aerodigestive_tract(6)|urinary_tract(4)	142		all_cancers(19;0.186)|Prostate(19;1.15e-05)|all_epithelial(19;0.0103)				GCATGTTGTCCTTCAGCCAGC	0.582000													25	23					0	0	1	0	0
ASAP1	50807	broad.mit.edu	37	8	131104255	131104255	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr8:131104255G>A	ENST00000357668.1	-	24	2563	c.2536C>T	c.(2536-2538)Cct>Tct	p.P846S	ASAP1_ENST00000518721.1_Missense_Mutation_p.P846S			Q9ULH1	ASAP1_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	846	Pro-rich.				cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			breast(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(22)|ovary(6)|pancreas(1)|prostate(1)|skin(3)|stomach(1)	68						GGCCCATGAGGTAGTGGGCTG	0.617000													72	105					0	0	1	0	0
SIGLEC14	100049587	broad.mit.edu	37	19	52146868	52146868	+	Missense_Mutation	SNP	A	A	C			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr19:52146868A>C	ENST00000360844.6	-	6	1111	c.1070T>G	c.(1069-1071)gTc>gGc	p.V357G	SIGLEC5_ENST00000222107.4_Intron|SIGLEC5_ENST00000599649.1_Intron|SIGLEC5_ENST00000534261.2_Intron|SIGLEC5_ENST00000429354.3_Intron	NM_001098612.1	NP_001092082.1	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14	357					cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(15)|ovary(1)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		CAGGGTGAGGACGAGGGGCCA	0.582000													25	40					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48390024	48390024	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:48390024G>A	ENST00000224600.4	-	1	967	c.854C>T	c.(853-855)tCc>tTc	p.S285F		NM_002900.2	NP_002891.1	P10745	RET3_HUMAN	retinol binding protein 3, interstitial	285	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	GGGCCCCAGGGACCTGGACAC	0.701000													10	6					0	0	1	0	0
CUL7	9820	broad.mit.edu	37	6	43011351	43011351	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr6:43011351G>A	ENST00000535468.1	-	17	3528	c.3442C>T	c.(3442-3444)Ccc>Tcc	p.P1148S	CUL7_ENST00000265348.3_Missense_Mutation_p.P1064S	NM_001168370.1|NM_014780.4	NP_001161842.1|NP_055595.2	Q14999	CUL7_HUMAN	cullin 7	1064					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(8)|liver(1)|lung(11)|ovary(3)|prostate(2)|skin(3)|stomach(1)|urinary_tract(1)	49			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			CAACCCAGGGGGCTAATGCCA	0.587000													10	9					0	0	1	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140307514	140307514	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:140307514C>T	ENST00000253807.2	+	1	1037	c.1037C>T	c.(1036-1038)tCg>tTg	p.S346L	PCDHA1_ENST00000504120.2_Intron|PCDHA13_ENST00000409494.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA13_ENST00000289272.2_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHAC1_ENST00000409700.3_Missense_Mutation_p.S346L|PCDHA10_ENST00000307360.5_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018898.3	NP_061721.2														NS(2)|breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|liver(2)|lung(13)|ovary(3)|prostate(2)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(4)	65			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGACTCTTTCGAACCCAGTA	0.517000													78	7					0	0	1	0	0
TRIM61	391712	broad.mit.edu	37	4	165891000	165891000	+	Missense_Mutation	SNP	G	G	A	rs142627348		TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr4:165891000G>A	ENST00000329314.5	-	3	767	c.155C>T	c.(154-156)cCc>cTc	p.P52L		NM_001012414.2	NP_001012414.1	Q5EBN2	TRI61_HUMAN	tripartite motif containing 61	52						intracellular	zinc ion binding	p.P52L(1)		NS(1)|kidney(1)|liver(1)|skin(1)|upper_aerodigestive_tract(1)	5	all_hematologic(180;0.221)	Prostate(90;0.109)		GBM - Glioblastoma multiforme(119;0.155)		AAAGGGGCAGGGGAAACTATC	0.453000													12	52					0	0	1	0	0
COL4A4	1286	broad.mit.edu	37	2	227915811	227915811	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:227915811C>T	ENST00000396625.3	-	33	3239	c.3032G>A	c.(3031-3033)gGa>gAa	p.G1011E	COL4A4_ENST00000329662.7_Missense_Mutation_p.G1011E	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	1011	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		TCTGTGAAATCCAGGTGGTCC	0.547000													45	77					0	0	1	0	0
HEPHL1	341208	broad.mit.edu	37	11	93754581	93754581	+	Missense_Mutation	SNP	T	T	G			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr11:93754581T>G	ENST00000315765.9	+	1	55	c.47T>G	c.(46-48)cTg>cGg	p.L16R		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	16					copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				CTCACATTCCTGGGTCTGTCT	0.502000													22	46					0	0	1	0	0
DSP	1832	broad.mit.edu	37	6	7572147	7572147	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr6:7572147G>A	ENST00000379802.3	+	15	2317	c.1976G>A	c.(1975-1977)aGa>aAa	p.R659K	DSP_ENST00000418664.2_Missense_Mutation_p.R659K	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	659	Globular 1.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GAAACCAACAGAGAAAATGAC	0.433000													41	45					0	0	1	0	0
XIRP2	129446	broad.mit.edu	37	2	168101652	168101652	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:168101652G>A	ENST00000409195.1	+	9	3839	c.3750G>A	c.(3748-3750)aaG>aaA	p.K1250K	XIRP2_ENST00000409273.1_Silent_p.K1028K|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000295237.9_Silent_p.K1250K|XIRP2_ENST00000409043.1_Intron|XIRP2_ENST00000409605.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	1075					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						CAATTGATAAGATAAAAGAAA	0.338000													29	28					0	0	1	0	0
CDC45	8318	broad.mit.edu	37	22	19486669	19486669	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr22:19486669C>T	ENST00000407835.1	+	10	955	c.699C>T	c.(697-699)atC>atT	p.I233I	CDC45_ENST00000404724.3_Silent_p.I187I|CDC45_ENST00000263201.1_Silent_p.I233I|CDC45_ENST00000437685.2_Silent_p.I265I			O75419	CDC45_HUMAN	cell division cycle 45	233					DNA replication checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|M/G1 transition of mitotic cell cycle|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	centrosome|nucleoplasm	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	19						AAGACAAGATCACTCAGTAAG	0.572000													55	74					0	0	1	0	0
C1R	715	broad.mit.edu	37	12	7241545	7241545	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:7241545C>T	ENST00000542285.1	-	6	952	c.803G>A	c.(802-804)gGg>gAg	p.G268E				P00736	C1R_HUMAN	complement component 1, r subcomponent	269	CUB 2.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	CCTTTGCTTCCCACAGAACTC	0.547000													5	7					0	0	1	0	0
PCDH15	65217	broad.mit.edu	37	10	55568560	55568560	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:55568560C>T	ENST00000395445.1	-	36	5644	c.5250G>A	c.(5248-5250)caG>caA	p.Q1750Q	PCDH15_ENST00000395442.1_Silent_p.Q615Q|PCDH15_ENST00000395440.1_Silent_p.Q684Q|PCDH15_ENST00000414778.1_Intron|PCDH15_ENST00000395438.1_3'UTR|PCDH15_ENST00000409834.1_3'UTR|PCDH15_ENST00000373965.2_Intron|PCDH15_ENST00000395446.1_Silent_p.Q946Q	NM_001142769.1	NP_001136241.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	0	Poly-Pro.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GACCTCCAGACTGACTTTCGC	0.498000										HNSCC(58;0.16)			9	4					0	0	1	0	0
RYK	6259	broad.mit.edu	37	3	133901898	133901898	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:133901898G>A	ENST00000427044.2	-	11	1163	c.553C>T	c.(553-555)Cag>Tag	p.Q185*	RYK_ENST00000296084.4_Nonsense_Mutation_p.Q375*			P34925	RYK_HUMAN	receptor-like tyrosine kinase	371	WIF.				corpus callosum development|positive regulation of MAPKKK cascade|Wnt receptor signaling pathway	cytoplasm|integral to plasma membrane|nucleus	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(1)|ovary(3)	4						ATTGTCACCTGAATTTCAGAA	0.343000													8	7					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179621496	179621496	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr2:179621496C>T	ENST00000589042.1	-	46	10931	c.10707G>A	c.(10705-10707)ggG>ggA	p.G3569G	TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Silent_p.G3398G|TTN-AS1_ENST00000578746.1_RNA|TTN_ENST00000591111.1_Intron|TTN_ENST00000360870.5_Intron|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN_ENST00000460472.2_Intron	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3253	Ig-like 21.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTACATCTTTCCCAGAACTTT	0.393000													8	13					0	0	1	0	0
ANKRD19P	138649	broad.mit.edu	37	9	95646227	95646227	+	RNA	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr9:95646227C>T	ENST00000473204.1	+	0	2143																											CTCCCAGTGTCCAGTAGGGCA	0.567000													40	2					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33465234	33465234	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr9:33465234G>A	ENST00000379471.2	-	20	2739	c.2652C>T	c.(2650-2652)ttC>ttT	p.F884F	NOL6_ENST00000455041.2_Silent_p.F832F|NOL6_ENST00000464829.1_Intron			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	884					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		CAGGGTGCAGGAAAAGGGCAG	0.617000													5	0					0	0	1	0	0
UBR5	51366	broad.mit.edu	37	8	103274276	103274276	+	Missense_Mutation	SNP	A	A	C			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr8:103274276A>C	ENST00000520539.1	-	55	8315	c.7709T>G	c.(7708-7710)tTt>tGt	p.F2570C	UBR5_ENST00000521922.1_Missense_Mutation_p.F2563C|UBR5_ENST00000518205.1_Missense_Mutation_p.F298C|UBR5_ENST00000220959.4_Missense_Mutation_p.F2569C	NM_015902.5	NP_056986.2	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin 5	2570	HECT.				cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			NS(1)|breast(13)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(19)|liver(1)|lung(51)|ovary(6)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	124	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			AGGATCAAAAAAAGCAAAATC	0.343000													17	30					0	0	1	0	0
SNHG14	104472715	broad.mit.edu	37	15	25476039	25476039	+	RNA	SNP	A	A	C			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr15:25476039A>C	ENST00000453082.2	+	0	1523				SNORD115-33_ENST00000363723.1_RNA	NR_003343.1																						ACTTAAAAATAATGCTCAATA	0.512000													6	456					0	0	1	0	0
OR5H14	403273	broad.mit.edu	37	3	97869149	97869149	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:97869149G>A	ENST00000437310.1	+	1	980	c.920G>A	c.(919-921)aGa>aAa	p.R307K		NM_001005514.1	NP_001005514.1	A6NHG9	O5H14_HUMAN	olfactory receptor, family 5, subfamily H, member 14	307					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	31						ATGTTCAAAAGAAATGATGTT	0.303000													11	5					0	0	1	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857387	9857387	+	Silent	SNP	C	C	T	rs61758997		TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr16:9857387C>T	ENST00000396573.2	-	14	4323	c.4014G>A	c.(4012-4014)ggG>ggA	p.G1338G	GRIN2A_ENST00000404927.2_Intron|GRIN2A_ENST00000562109.1_Intron|GRIN2A_ENST00000535259.1_Intron|GRIN2A_ENST00000330684.3_Silent_p.G1338G|GRIN2A_ENST00000396575.2_Silent_p.G1338G	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	1338					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AGCTTTTTTTCCCCGAGAGTT	0.552000													30	42					0	0	1	0	0
CNTNAP4	85445	broad.mit.edu	37	16	76461443	76461443	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr16:76461443G>A	ENST00000307431.8	+	5	867	c.482G>A	c.(481-483)tGg>tAg	p.W161*	CNTNAP4_ENST00000478060.1_Nonsense_Mutation_p.W137*|CNTNAP4_ENST00000476707.1_Nonsense_Mutation_p.W165*|CNTNAP4_ENST00000377504.4_Nonsense_Mutation_p.W161*|CNTNAP4_ENST00000469589.1_3'UTR	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	162	F5/8 type C.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						CCTTTGGAATGGAACCCCAAG	0.408000													27	30					0	0	1	0	0
C20orf166-AS1	253868	broad.mit.edu	37	20	61143348	61143348	+	RNA	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr20:61143348C>T	ENST00000475015.1	-	0	990				C20orf166-AS1_ENST00000412495.1_RNA																							AGGGCCCTCCCCTGGACAAGG	0.682000													12	13					0	0	1	0	0
CRB2	286204	broad.mit.edu	37	9	126128626	126128626	+	Silent	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr9:126128626C>T	ENST00000373631.3	+	4	736	c.735C>T	c.(733-735)ttC>ttT	p.F245F	CRB2_ENST00000359999.3_Silent_p.F245F	NM_173689.5	NP_775960.4	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 (Drosophila)	245	EGF-like 5.					extracellular region|integral to membrane|plasma membrane	calcium ion binding			NS(2)|breast(1)|cervix(1)|endometrium(2)|lung(11)|ovary(1)|prostate(2)|skin(3)	23						TCGGGAGCTTCCGCTGCCTCT	0.736000													10	18					0	0	1	0	0
ZPLD1	131368	broad.mit.edu	37	3	102196336	102196336	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:102196336G>A	ENST00000306176.1	+	11	1270	c.1170G>A	c.(1168-1170)ctG>ctA	p.L390L	ZPLD1_ENST00000491959.1_Silent_p.L374L|ZPLD1_ENST00000466937.1_Silent_p.L374L	NM_175056.1	NP_778226.1	Q8TCW7	ZPLD1_HUMAN	zona pellucida-like domain containing 1	374						integral to membrane				central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(18)|ovary(2)|skin(3)	35						CCAGCGCACTGATATCAGGAA	0.468000													109	101					0	0	1	0	0
THNSL1	79896	broad.mit.edu	37	10	25313734	25313734	+	Nonsense_Mutation	SNP	C	C	T	rs139395919	by1000genomes	TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr10:25313734C>T	ENST00000524413.1	+	3	1929	c.1582C>T	c.(1582-1584)Cga>Tga	p.R528*	THNSL1_ENST00000376356.4_Nonsense_Mutation_p.R528*			Q8IYQ7	THNS1_HUMAN	threonine synthase-like 1 (S. cerevisiae)	528					threonine biosynthetic process		ATP binding|pyridoxal phosphate binding|shikimate kinase activity|threonine synthase activity			NS(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|lung(5)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28					L-Threonine(DB00156)|Pyridoxal Phosphate(DB00114)	AATCCCGATTCGAAAATTTAT	0.363000													28	51					0	0	1	0	0
LRFN5	145581	broad.mit.edu	37	14	42368155	42368155	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr14:42368155G>A	ENST00000298119.4	+	5	3323	c.2134G>A	c.(2134-2136)Gaa>Aaa	p.E712K	LRFN5_ENST00000554120.1_Intron|LRFN5_ENST00000554171.1_3'UTR	NM_152447.3	NP_689660.2	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III domain containing 5	712						integral to membrane		p.E712*(1)		breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(12)|liver(1)|lung(67)|ovary(5)|pancreas(3)|prostate(1)|skin(9)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(2)	120			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		GATTGTCCAGGAAACACAGGT	0.279000										HNSCC(30;0.082)			38	53					0	0	1	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2894600	2894600	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr17:2894600G>A	ENST00000254695.8	+	12	913	c.823G>A	c.(823-825)Gag>Aag	p.E275K	RAP1GAP2_ENST00000540393.2_Missense_Mutation_p.E256K|RAP1GAP2_ENST00000542807.1_Missense_Mutation_p.E275K|RAP1GAP2_ENST00000366401.4_Missense_Mutation_p.E260K	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	275	Rap-GAP.				regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						GACCCTGGAGGAGGAGCTATT	0.473000													4	0					0	0	1	0	0
OR10Z1	128368	broad.mit.edu	37	1	158577107	158577107	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:158577107G>A	ENST00000361284.1	+	1	879	c.879G>A	c.(877-879)agG>agA	p.R293R		NM_001004478.1	NP_001004478.1	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z, member 1	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(6)|lung(21)|pancreas(1)|prostate(3)|skin(4)	37	all_hematologic(112;0.0378)					ATAGTCTAAGGAATAGGGCTA	0.463000													104	111					0	0	1	0	0
OR5H2	79310	broad.mit.edu	37	3	98002110	98002110	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:98002110C>T	ENST00000355273.2	+	1	379	c.379C>T	c.(379-381)Cgc>Tgc	p.R127C	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005482.1	NP_001005482.1	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H, member 2	127					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						GGCATATGATCGCTATGTAGC	0.378000													41	39					0	0	1	0	0
SLC2A2	6514	broad.mit.edu	37	3	170724939	170724939	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:170724939G>A	ENST00000314251.3	-	5	689	c.610C>T	c.(610-612)Cag>Tag	p.Q204*	SLC2A2_ENST00000382808.4_Nonsense_Mutation_p.Q85*	NM_000340.1	NP_000331.1	P11168	GTR2_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 2	204					carbohydrate metabolic process|cellular lipid metabolic process|endocrine pancreas development|energy reserve metabolic process|regulation of insulin secretion	integral to plasma membrane|membrane fraction	D-glucose transmembrane transporter activity			central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24	all_cancers(22;1.41e-19)|all_lung(20;1.59e-15)|Lung NSC(18;7.08e-15)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;1.1e-14)|Lung(28;2.99e-14)			GTTTTTACCTGACTAATAAGA	0.483000													17	12					0	0	1	0	0
APOBR	55911	broad.mit.edu	37	16	28509498	28509498	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr16:28509498C>T	ENST00000564831.1	+	3	3085	c.3052C>T	c.(3052-3054)Cgt>Tgt	p.R1018C	APOBR_ENST00000431282.1_Missense_Mutation_p.R1009C|APOBR_ENST00000328423.5_Missense_Mutation_p.R1009C	NM_018690.3	NP_061160.3	Q0VD83	APOBR_HUMAN	apolipoprotein B receptor	1009					cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|skin(2)|stomach(1)	29						GCCCTCTTTTCGTCGGACTCC	0.682000													4	9					0	0	1	0	0
TMEM109	79073	broad.mit.edu	37	11	60689555	60689555	+	Missense_Mutation	SNP	G	G	C			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr11:60689555G>C	ENST00000227525.3	+	4	1053	c.650G>C	c.(649-651)cGa>cCa	p.R217P	TMEM109_ENST00000536171.1_Missense_Mutation_p.R217P|RP11-881M11.4_ENST00000543907.1_RNA	NM_024092.2	NP_076997.1	Q9BVC6	TM109_HUMAN	transmembrane protein 109	217						integral to membrane|nuclear outer membrane|sarcoplasmic reticulum membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(1)|ovary(1)|skin(1)	8						GCCAAGGTGCGAGGGCTGGAA	0.706000													7	18					0	0	1	0	0
LINC00359	100887754	broad.mit.edu	37	13	97600276	97600276	+	RNA	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr13:97600276G>A	ENST00000442322.1	-	0	241																											AAATCAGTTGGATCAGTGGAG	0.418000													3	12					0	0	1	0	0
C9orf142	286257	broad.mit.edu	37	9	139887846	139887846	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr9:139887846C>T	ENST00000371620.3	+	5	499	c.473C>T	c.(472-474)cCt>cTt	p.P158L	C9orf142_ENST00000493968.1_3'UTR	NM_183241.1	NP_899064.1	Q9BUH6	CI142_HUMAN	chromosome 9 open reading frame 142	158												all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CCTGCAGGGCCTCAGCTCTTC	0.602000													5	1					0	0	1	0	0
TBC1D10C	374403	broad.mit.edu	37	11	67171762	67171762	+	Missense_Mutation	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr11:67171762G>A	ENST00000312390.5	+	2	118	c.89G>A	c.(88-90)gGg>gAg	p.G30E	TBC1D10C_ENST00000542590.1_Missense_Mutation_p.G30E|TBC1D10C_ENST00000526387.1_Missense_Mutation_p.G30E	NM_198517.3	NP_940919.1	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	30						intracellular	Rab GTPase activator activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			GAGCTCAGCGGGCCTGGCCCA	0.687000													19	8					0	0	1	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263656	140263656	+	Silent	SNP	G	G	A			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:140263656G>A	ENST00000289272.2	+	1	1803	c.1803G>A	c.(1801-1803)tcG>tcA	p.S601S	PCDHA1_ENST00000504120.2_Intron|PCDHA13_ENST00000409494.1_Silent_p.S601S|PCDHA7_ENST00000525929.1_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA6_ENST00000527624.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACGCCGATTCGGGCTACAATG	0.697000													76	5					0	0	1	0	0
GATM	2628	broad.mit.edu	37	15	45661694	45661694	+	Missense_Mutation	SNP	G	G	A	rs147804855		TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr15:45661694G>A	ENST00000396659.3	-	3	653	c.314C>T	c.(313-315)cCa>cTa	p.P105L	GATM_ENST00000558336.1_Missense_Mutation_p.P105L	NM_001482.2	NP_001473.1	P50440	GATM_HUMAN	glycine amidinotransferase (L-arginine:glycine amidinotransferase)	105					creatine biosynthetic process	mitochondrial inner membrane|mitochondrial intermembrane space	glycine amidinotransferase activity|protein binding			biliary_tract(1)|breast(1)|endometrium(1)|large_intestine(2)|lung(6)|prostate(2)|skin(1)|urinary_tract(1)	15		all_cancers(109;1.25e-09)|all_epithelial(112;5.56e-08)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;4.87e-16)|GBM - Glioblastoma multiforme(94;1.97e-06)	Creatine(DB00148)|Glycine(DB00145)|L-Ornithine(DB00129)	CTGGTAAAATGGCCAGTACTT	0.363000													12	19					0	0	1	0	0
RANBP17	64901	broad.mit.edu	37	5	170346460	170346460	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr5:170346460C>T	ENST00000523189.1	+	11	1281	c.1117C>T	c.(1117-1119)Cct>Tct	p.P373S		NM_022897.3	NP_075048.1	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	373					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(25)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	50	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			GGAATTTGCTCCTAACAGTGT	0.323000			T	TRD@	ALL								27	31					0	0	1	0	0
TNFRSF8	943	broad.mit.edu	37	1	12164553	12164553	+	Missense_Mutation	SNP	C	C	T			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:12164553C>T	ENST00000263932.2	+	4	608	c.386C>T	c.(385-387)tCt>tTt	p.S129F	TNFRSF8_ENST00000417814.2_Missense_Mutation_p.S18F	NM_001243.3	NP_001234.2	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	129					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane		p.S129F(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		TTCTTCCATTCTGTCTGTCCG	0.577000													26	22					0	0	1	0	0
LOC100129620	100129620	broad.mit.edu	37	1	99474094	99474094	+	RNA	DEL	A	A	-	rs57656522		TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr1:99474094delA	ENST00000425113.1	+	0	370					NR_033940.1																						AACAGCAACTAAAAAAAAAAA	0.353													2	4	---	---	---	---					
LRIG1	26018	broad.mit.edu	37	3	66436625	66436627	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr3:66436625_66436627delGCT	ENST00000383703.3	-	14	2242_2244	c.1639_1641delAGC	c.(1639-1641)del	p.S548del	LRIG1_ENST00000273261.3_In_Frame_Del_p.S524del|LRIG1_ENST00000496559.2_5'UTR|SLC25A26_ENST00000536651.1_3'UTR			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	524	Ig-like C2-type 1.					integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		TCATGGGGGAGCTGCTGCTGCTG	0.547													8	526	---	---	---	---					
SRF	6722	broad.mit.edu	37	6	43139485	43139487	+	In_Frame_Del	DEL	GGC	GGC	-			TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr6:43139485_43139487delGGC	ENST00000265354.4	+	1	449_451	c.91_93delGGC	c.(91-93)del	p.G35del		NM_003131.2	NP_003122.1	P11831	SRF_HUMAN	serum response factor (c-fos serum response element-binding transcription factor)	35	Gly-rich.				angiogenesis involved in wound healing|cell migration involved in sprouting angiogenesis|cellular senescence|heart looping|muscle cell homeostasis|neuron development|positive regulation of cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of smooth muscle cell differentiation|response to cytokine stimulus|response to hormone stimulus|response to toxin|transcription from RNA polymerase II promoter|trophectodermal cell differentiation	endoplasmic reticulum	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)	12			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.011)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			ggggcggccgggcggcggcggcg	0.818													2	4	---	---	---	---					
EMG1	10436	broad.mit.edu	37	12	7080212	7080213	+	RNA	INS	-	-	C	rs36063533		TCGA-EE-A3J8-06A-11D-A20D-08	TCGA-EE-A3J8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	aec50919-7be5-4848-8a88-5055bff72f86	0c498759-5af7-4f87-b6bc-0443be965aed	g.chr12:7080212_7080213insC	ENST00000546220.1	+	0	157_158				U47924.19_ENST00000564245.1_RNA|U47924.28_ENST00000261406.6_lincRNA			Q92979	NEP1_HUMAN	EMG1 N1-specific pseudouridine methyltransferase						ribosomal small subunit biogenesis	cytoplasm|nucleolus	rRNA (pseudouridine) methyltransferase activity|rRNA binding										GAGGCCGTAGTTTATTGTGGTG	0.569													7	17	---	---	---	---					
