Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SIPA1L2	57568	broad.mit.edu	37	1	232575079	232575079	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr1:232575079G>A	ENST00000366630.1	-	14	4164	c.3806C>T	c.(3805-3807)aCg>aTg	p.T1269M	SIPA1L2_ENST00000308942.4_Missense_Mutation_p.T343M|SIPA1L2_ENST00000262861.4_Missense_Mutation_p.T1269M			Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like 2	1269					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GCAGGGGGCCGTGTCGATGCC	0.642000													3	84					0	0	1	0	0
POM121L9P	29774	broad.mit.edu	37	22	24659536	24659536	+	RNA	SNP	C	C	T			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr22:24659536C>T	ENST00000414583.2	+	0	3061					NR_003714.1																						GATCTCATCGCGGACACCACT	0.512000													5	30					0	0	1	0	0
ISLR	3671	broad.mit.edu	37	15	74467459	74467459	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr15:74467459G>A	ENST00000249842.3	+	2	617	c.260G>A	c.(259-261)cGc>cAc	p.R87H	RP11-665J16.1_ENST00000561647.1_RNA|ISLR_ENST00000395118.1_Missense_Mutation_p.R87H	NM_005545.3	NP_005536.1	O14498	ISLR_HUMAN	immunoglobulin superfamily containing leucine-rich repeat	87					cell adhesion	extracellular region				central_nervous_system(1)|large_intestine(7)|lung(8)|ovary(1)|prostate(2)|skin(1)	20						AATGAGATCCGCACGGTGGCC	0.637000													3	42					0	0	1	0	0
FBLN5	10516	broad.mit.edu	37	14	92361349	92361349	+	Silent	SNP	G	G	A			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr14:92361349G>A	ENST00000267620.10	-	6	739	c.570C>T	c.(568-570)ggC>ggT	p.G190G	FBLN5_ENST00000342058.4_Silent_p.G149G|FBLN5_ENST00000556154.1_Silent_p.G154G			Q9UBX5	FBLN5_HUMAN	fibulin 5	149	EGF-like 3; calcium-binding (Potential).				cell-matrix adhesion|elastic fiber assembly|protein localization at cell surface|regulation of removal of superoxide radicals	extracellular space|proteinaceous extracellular matrix|soluble fraction	calcium ion binding|integrin binding|protein C-terminus binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	28		all_cancers(154;0.0722)				AGGTGTACCCGCCTTCAGTAT	0.522000													44	42					0	0	1	0	0
PCDHB5	26167	broad.mit.edu	37	5	140515200	140515200	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr5:140515200C>T	ENST00000231134.5	+	1	401	c.184C>T	c.(184-186)Cgg>Tgg	p.R62W		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		62	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACTGGCCACTCGGGGCGCGCG	0.488000													57	59					0	0	1	0	0
TASP1	55617	broad.mit.edu	37	20	13514718	13514718	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr20:13514718G>A	ENST00000337743.4	-	9	866	c.746C>T	c.(745-747)gCt>gTt	p.A249V	TASP1_ENST00000539805.1_Intron|TASP1_ENST00000480436.1_5'UTR	NM_017714.2	NP_060184.2	Q9H6P5	TASP1_HUMAN	taspase, threonine aspartase, 1	249					asparagine catabolic process via L-aspartate|positive regulation of transcription, DNA-dependent|protein maturation		threonine-type endopeptidase activity			NS(1)|breast(1)|endometrium(2)|large_intestine(11)|liver(1)|lung(11)|stomach(2)|urinary_tract(2)	31						ACTGGAGACAGCAGCAGCAAC	0.483000													3	43					0	0	1	0	0
GLUD1P7	414212	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	A	G			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr10:48968566A>G	ENST00000594520.1	+	0	723																											ACAGGATAACAAACTGGAAAA	0.318000													4	44					0	0	1	0	0
ZNF408	79797	broad.mit.edu	37	11	46726766	46726766	+	Missense_Mutation	SNP	C	C	A			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr11:46726766C>A	ENST00000311764.2	+	5	1746	c.1516C>A	c.(1516-1518)Cgt>Agt	p.R506S		NM_001184751.1|NM_024741.2	NP_001171680.1|NP_079017.1	Q9H9D4	ZN408_HUMAN	zinc finger protein 408	506					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|identical protein binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						CCGGGCGTTTCGTCAGCGGGG	0.657000													3	74					1	1	1	1	0
SF3B1	23451	broad.mit.edu	37	2	198267483	198267483	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr2:198267483C>T	ENST00000335508.5	-	14	1965	c.1874G>A	c.(1873-1875)cGt>cAt	p.R625H		NM_012433.2	NP_036565.2	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1, 155kDa	625					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding	p.R625L(9)|p.R625P(2)|p.R625H(1)		NS(35)|breast(10)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(524)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|pancreas(4)|prostate(6)|salivary_gland(1)|skin(4)|testis(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	633			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TGTTGTGTTACGGACATACTC	0.438000			Mis		myelodysplastic syndrome								28	13					0	0	1	0	0
GNA11	2767	broad.mit.edu	37	19	3118942	3118942	+	Missense_Mutation	SNP	A	A	T			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr19:3118942A>T	ENST00000078429.4	+	5	868	c.626A>T	c.(625-627)cAg>cTg	p.Q209L	AC005262.3_ENST00000587701.1_RNA|GNA11_ENST00000586180.1_3'UTR	NM_002067.2	NP_002058.2	P29992	GNA11_HUMAN	guanine nucleotide binding protein (G protein), alpha 11 (Gq class)	209					activation of phospholipase C activity by dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation|regulation of action potential	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity	p.Q209L(80)|p.Q209P(2)		endometrium(2)|eye(132)|kidney(1)|large_intestine(2)|lung(1)|meninges(5)|ovary(1)|prostate(1)|skin(16)	161		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.79e-05)|OV - Ovarian serous cystadenocarcinoma(105;2.68e-113)|Epithelial(107;1.22e-111)|all cancers(105;5.78e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00141)|STAD - Stomach adenocarcinoma(1328;0.181)		GTGGGGGGCCAGCGGTCGGAG	0.612000			Mis		uveal melanoma								39	48					0	0	1	0	0
SEMA4G	57715	broad.mit.edu	37	10	102739634	102739634	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr10:102739634G>A	ENST00000210633.3	+	9	1091	c.1013G>A	c.(1012-1014)cGc>cAc	p.R338H	MRPL43_ENST00000370241.3_Intron|MRPL43_ENST00000370242.4_Intron|SEMA4G_ENST00000517724.1_Missense_Mutation_p.R338H|SEMA4G_ENST00000370250.4_Missense_Mutation_p.R338H|MRPL43_ENST00000318325.2_Intron			Q9NTN9	SEM4G_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	338	Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			breast(3)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25		Colorectal(252;0.234)		Epithelial(162;3.71e-09)|all cancers(201;2.1e-07)		GCCATCTGCCGCTATGACCTG	0.602000													76	105					0	0	1	0	0
SRGAP2	23380	broad.mit.edu	37	1	206603533	206603533	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr1:206603533C>G	ENST00000414007.1	+	10	1096	c.1096C>G	c.(1096-1098)Ctg>Gtg	p.L366V	SRGAP2_ENST00000419187.2_5'UTR			O75044	FNBP2_HUMAN	SLIT-ROBO Rho GTPase activating protein 2	506					axon guidance|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			NS(1)|breast(1)|kidney(1)|lung(1)	4	Breast(84;0.137)					GGCAATTCCTCTGGTGGTGGA	0.473000													116	70					0	0	1	0	0
MMP11	4320	broad.mit.edu	37	22	24123560	24123560	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr22:24123560T>G	ENST00000215743.3	+	6	1091	c.1039T>G	c.(1039-1041)Ttc>Gtc	p.F347V		NM_005940.3	NP_005931.2	P24347	MMP11_HUMAN	matrix metallopeptidase 11 (stromelysin 3)	347	Hemopexin-like 2.				collagen catabolic process|multicellular organismal development|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)	27		Medulloblastoma(6;9.86e-08)|all_neural(6;0.000318)				GGACGCTGCCTTCGAGGATGC	0.647000													5	10					0	0	1	0	0
ATP6V1A	523	broad.mit.edu	37	3	113505224	113505224	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr3:113505224T>C	ENST00000273398.3	+	6	818	c.710T>C	c.(709-711)cTt>cCt	p.L237P	ATP6V1A_ENST00000538620.1_Missense_Mutation_p.L204P	NM_001690.3	NP_001681.2	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	237					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						CTTGATGCCCTTTTTCCGTAA	0.423000													4	223					0	0	1	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102304785	102304785	+	RNA	SNP	G	G	A			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr15:102304785G>A	ENST00000561463.1	+	0	12831																											CGAGACTCGCGTGGGAAGAAG	0.592000													3	16					0	0	1	0	0
PNP	4860	broad.mit.edu	37	14	20942733	20942733	+	Splice_Site	SNP	A	A	T			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr14:20942733A>T	ENST00000361505.5	+	3	430	c.285_splice	c.e3+1	p.K95_splice		NM_000270.3	NP_000261.2	P00491	PNPH_HUMAN	purine nucleoside phosphorylase	95					immune response|inosine catabolic process|interleukin-2 secretion|NAD biosynthesis via nicotinamide riboside salvage pathway|nicotinamide riboside catabolic process|positive regulation of alpha-beta T cell differentiation|positive regulation of T cell proliferation|purine base metabolic process|purine nucleotide catabolic process|purine-containing compound salvage|response to drug|urate biosynthetic process	cytoskeleton|cytosol	drug binding|nucleoside binding|phosphate binding|purine base binding|purine-nucleoside phosphorylase activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(2)|stomach(2)	10					Aciclovir(DB00787)|Cladribine(DB00242)|Mercaptopurine(DB01033)	CCACTCTGGAAGGTAAGTCAG	0.532000													42	47					0	0	1	0	0
B4GALNT3	283358	broad.mit.edu	37	12	659075	659075	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr12:659075C>T	ENST00000266383.5	+	10	1007	c.994C>T	c.(994-996)Cga>Tga	p.R332*		NM_173593.3	NP_775864.3	Q6L9W6	B4GN3_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 3	332						Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(10;0.0158)|all_epithelial(11;0.0274)|Ovarian(42;0.0512)|all_lung(10;0.154)|Lung NSC(10;0.215)		OV - Ovarian serous cystadenocarcinoma(31;0.00018)|BRCA - Breast invasive adenocarcinoma(9;0.0262)			CACCCTCTATCGAGGTAAGGC	0.627000													12	13					0	0	1	0	0
TPTE2P2	644623	broad.mit.edu	37	13	52865661	52865661	+	RNA	SNP	C	C	A			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr13:52865661C>A	ENST00000451298.1	-	0	31				RP11-64P12.8_ENST00000606031.1_RNA																							AAGGATGACACAATTGAATGA	0.289000													3	34					0.150653	0.157064	1	1	0
ZFAND4	93550	broad.mit.edu	37	10	46122243	46122243	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr10:46122243T>G	ENST00000374366.3	-	8	1271	c.806A>C	c.(805-807)cAt>cCt	p.H269P	ZFAND4_ENST00000344646.5_Missense_Mutation_p.H343P|ZFAND4_ENST00000374371.2_Intron|ZFAND4_ENST00000374370.1_5'UTR			Q86XD8	ANUB1_HUMAN	zinc finger, AN1-type domain 4	343							zinc ion binding										CAACTCCAAATGGGGTATCTG	0.428000													30	39					0	0	1	0	0
IDH1	3417	broad.mit.edu	37	2	209113113	209113113	+	Missense_Mutation	SNP	G	G	A	rs121913499		TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr2:209113113G>A	ENST00000415913.1	-	4	775	c.394C>T	c.(394-396)Cgt>Tgt	p.R132C	IDH1_ENST00000446179.1_Missense_Mutation_p.R132C|IDH1_ENST00000345146.2_Missense_Mutation_p.R132C			O75874	IDHC_HUMAN	isocitrate dehydrogenase 1 (NADP+), soluble	132			R -> C (in colorectal cancer and glioma samples; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha- ketoglutarate but instead alpha- ketoglutarate is converted to R(-)-2- hydroxyglutarate).|R -> G (in a glioma sample; glioblastoma multiforme; somatic mutation).|R -> H (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> L (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).|R -> S (in a glioma sample; glioblastoma multiforme; somatic mutation; abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate).		2-oxoglutarate metabolic process|cellular lipid metabolic process|glyoxylate cycle|isocitrate metabolic process|NADPH regeneration|tricarboxylic acid cycle	cytosol|peroxisomal matrix	isocitrate dehydrogenase (NADP+) activity|magnesium ion binding|NAD binding|protein homodimerization activity	p.R132C(446)|p.R132G(125)|p.R132S(106)|p.G131_R132>VL(1)|p.R132V(1)		NS(1)|autonomic_ganglia(2)|biliary_tract(24)|bone(237)|central_nervous_system(3764)|endometrium(3)|haematopoietic_and_lymphoid_tissue(794)|kidney(2)|large_intestine(7)|lung(7)|prostate(6)|skin(5)|soft_tissue(12)|thyroid(22)|urinary_tract(1)	4887				Epithelial(149;0.0322)|LUSC - Lung squamous cell carcinoma(261;0.0711)|Lung(261;0.136)		TAAGCATGACGACCTATGATG	0.398000			Mis		gliobastoma								39	48					0	0	1	0	0
HK3	3101	broad.mit.edu	37	5	176314705	176314705	+	Silent	SNP	C	C	T	rs143340857		TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr5:176314705C>T	ENST00000292432.5	-	11	1438	c.1347G>A	c.(1345-1347)ccG>ccA	p.P449P		NM_002115.2	NP_002106.2	P52790	HXK3_HUMAN	hexokinase 3 (white cell)	449	Regulatory.				glucose transport|glycolysis|transmembrane transport	cytosol|membrane	ATP binding|glucokinase activity			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(21)|ovary(3)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47	all_cancers(89;0.000104)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CATCGCATTCCGGGGCCAGGA	0.652000													32	35					0	0	1	0	0
PDE7B	27115	broad.mit.edu	37	6	136476824	136476824	+	Silent	SNP	C	C	T			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr6:136476824C>T	ENST00000308191.6	+	8	942	c.639C>T	c.(637-639)caC>caT	p.H213H	RP13-143G15.4_ENST00000417643.1_RNA|RP13-143G15.4_ENST00000591521.1_RNA|RP13-143G15.4_ENST00000585946.1_RNA	NM_018945.3	NP_061818.1	Q9NP56	PDE7B_HUMAN	phosphodiesterase 7B	213	Catalytic (By similarity).				signal transduction|synaptic transmission	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Colorectal(23;0.24)			OV - Ovarian serous cystadenocarcinoma(155;0.0136)|GBM - Glioblastoma multiforme(68;0.0147)	Dyphylline(DB00651)|Ketotifen(DB00920)	CAGCAGCACACGATGTGGACC	0.488000													3	37					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14513764	14513764	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr18:14513764C>T	ENST00000358970.5	-	10	1429	c.1430G>A	c.(1429-1431)cGg>cAg	p.R477Q		NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	477								p.R477Q(12)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						AAGTTGTTTCCGGGTATCATT	0.358000													3	43					0	0	1	0	0
ACTL7B	10880	broad.mit.edu	37	9	111617776	111617776	+	Silent	SNP	G	G	A	rs149121708	byFrequency	TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr9:111617776G>A	ENST00000374667.3	-	1	1463	c.435C>T	c.(433-435)caC>caT	p.H145H		NM_006686.3	NP_006677.1	Q9Y614	ACL7B_HUMAN	actin-like 7B	145						actin cytoskeleton|cytoplasm	structural constituent of cytoskeleton			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(8)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20						CCAGCACAGCGTGCTCCTCGG	0.622000													34	36					0	0	1	0	0
SLC24A5	283652	broad.mit.edu	37	15	48426522	48426522	+	Missense_Mutation	SNP	A	A	C			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr15:48426522A>C	ENST00000341459.3	+	3	442	c.369A>C	c.(367-369)ttA>ttC	p.L123F	SLC24A5_ENST00000449382.2_Missense_Mutation_p.L63F	NM_205850.2	NP_995322.1	Q71RS6	NCKX5_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 5	123					response to stimulus	integral to membrane|melanosome|plasma membrane	calcium, potassium:sodium antiporter activity|symporter activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(17)|skin(1)|upper_aerodigestive_tract(1)	27		all_lung(180;0.00217)		all cancers(107;3.29e-10)|GBM - Glioblastoma multiforme(94;7.32e-07)		CTCCTGAATTAGTTACTGCTT	0.383000													21	19					0	0	1	0	0
ZFP30	22835	broad.mit.edu	37	19	38135567	38135567	+	Missense_Mutation	SNP	T	T	G			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr19:38135567T>G	ENST00000351218.2	-	4	637	c.80A>C	c.(79-81)cAg>cCg	p.Q27P	ZFP30_ENST00000514101.2_Missense_Mutation_p.Q27P|ZFP30_ENST00000392144.1_Missense_Mutation_p.Q27P|ZFP30_ENST00000589018.1_Missense_Mutation_p.Q27P	NM_014898.2	NP_055713.1	Q9Y2G7	ZFP30_HUMAN	ZFP30 zinc finger protein	27	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	21			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			CAAATTCCTCTGATATGAGTT	0.383000													48	63					0	0	1	0	0
MTMR11	10903	broad.mit.edu	37	1	149904215	149904215	+	Silent	SNP	A	A	T			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr1:149904215A>T	ENST00000439741.2	-	11	1243	c.993T>A	c.(991-993)tcT>tcA	p.S331S	MTMR11_ENST00000492824.1_5'UTR|MTMR11_ENST00000361405.6_Intron|MTMR11_ENST00000406732.3_Silent_p.S303S|MTMR11_ENST00000369140.3_Silent_p.S259S	NM_001145862.1	NP_001139334.1	A4FU01	MTMRB_HUMAN	myotubularin related protein 11	331	Myotubularin phosphatase.						phosphatase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(13)|prostate(2)|stomach(1)|urinary_tract(4)	34	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			CCTCAGCTACAGATGAATCTG	0.448000													112	105					0	0	1	0	0
RRN3P1	730092	broad.mit.edu	37	16	21817457	21817457	+	RNA	SNP	G	G	A	rs150520281	by1000genomes	TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr16:21817457G>A	ENST00000546471.1	-	0	1601																											CTTACATCCAGCTTGAGTAGT	0.259000													4	36					0	0	1	0	0
UBBP4	23666	broad.mit.edu	37	17	21730847	21730847	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr17:21730847G>T	ENST00000584755.1	+	2	546	c.149G>T	c.(148-150)cGg>cTg	p.R50L	UBBP4_ENST00000583708.1_Intron|UBBP4_ENST00000584398.1_Intron|UBBP4_ENST00000578713.1_Missense_Mutation_p.R50L																endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GGCAAGCAGCGGGAAGATGGC	0.522000													4	58					0.00909568	0.00968888	1	1	0
OR1S1	219959	broad.mit.edu	37	11	57982680	57982680	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr11:57982680T>C	ENST00000309433.6	+	1	464	c.464T>C	c.(463-465)aTt>aCt	p.I155T		NM_001004458.1	NP_001004458.1	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S, member 1	155					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(24)|kidney(1)|large_intestine(1)|liver(1)|lung(10)|prostate(1)|skin(2)|stomach(3)|urinary_tract(3)	48		Breast(21;0.0589)				AGGTTCGGCATTTTGCTCACA	0.468000													5	227					0	0	1	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													4	80					0	0	1	0	0
SNAI2	6591	broad.mit.edu	37	8	49832991	49832991	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr8:49832991G>A	ENST00000396822.1	-	3	446	c.89C>T	c.(88-90)tCc>tTc	p.S30F	SNAI2_ENST00000020945.1_Missense_Mutation_p.S30F			O43623	SNAI2_HUMAN	snail family zinc finger 2	30					canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.S30F(1)		endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)	18		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				GAGATACGGGGAAATAATCAC	0.428000													86	87					0	0	1	0	0
SLC22A11	55867	broad.mit.edu	37	11	64329854	64329854	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr11:64329854G>T	ENST00000301891.4	+	4	1142	c.768G>T	c.(766-768)agG>agT	p.R256S	SLC22A11_ENST00000490834.1_3'UTR|SLC22A11_ENST00000377585.3_Missense_Mutation_p.R256S|SLC22A11_ENST00000377581.3_Missense_Mutation_p.R256S	NM_018484.2	NP_060954.1	Q9NSA0	S22AB_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 11	256					urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23					Probenecid(DB01032)	GGGACTGGAGGACTCTCCAGC	0.637000													231	371					1.75812e-138	2.00343e-138	1	1	0
SON	6651	broad.mit.edu	37	21	34927682	34927682	+	Missense_Mutation	SNP	C	C	A			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr21:34927682C>A	ENST00000356577.4	+	3	6620	c.6145C>A	c.(6145-6147)Cgt>Agt	p.R2049S	SON_ENST00000381679.4_Missense_Mutation_p.R2049S|SON_ENST00000381692.2_Intron|SON_ENST00000300278.4_Missense_Mutation_p.R2049S|SON_ENST00000290239.6_Missense_Mutation_p.R2049S	NM_138927.1	NP_620305.1	P18583	SON_HUMAN	SON DNA binding protein	2049					anti-apoptosis|cytokinesis|mRNA processing|regulation of cell cycle|regulation of RNA splicing|RNA splicing|spindle pole body separation	nuclear speck	DNA binding|double-stranded RNA binding			breast(3)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(25)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	72						ATCACCCAAACGTCTGACAGA	0.393000													3	104					0.00909568	0.00968888	1	1	0
CDH23	64072	broad.mit.edu	37	10	73270925	73270925	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr10:73270925G>A	ENST00000224721.6	+	5	390	c.385G>A	c.(385-387)Gcg>Acg	p.A129T	CDH23_ENST00000299366.7_Missense_Mutation_p.A174T|CDH23_ENST00000461841.3_Missense_Mutation_p.A174T|CDH23-AS1_ENST00000428918.1_RNA|CDH23_ENST00000398809.4_Missense_Mutation_p.A129T|CDH23_ENST00000398842.3_Missense_Mutation_p.A129T	NM_022124.5	NP_071407.4	Q9H251	CAD23_HUMAN	cadherin-related 23	129	Cadherin 1.				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			NS(1)|breast(2)|central_nervous_system(6)|endometrium(15)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(27)|lung(49)|ovary(3)|pancreas(1)|prostate(7)|stomach(7)|upper_aerodigestive_tract(3)	133						GAATGACAACGCGCCCACATT	0.582000													60	102					0	0	1	0	0
LOC220729	220729	broad.mit.edu	37	3	197348739	197348739	+	RNA	SNP	G	G	C			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr3:197348739G>C	ENST00000418868.1	-	0	520					NR_003266.2																						TAATTTTCTAGCTGTGAAAGA	0.398000													3	118					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000595295.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													3	17					1	1	1	1	0
AMZ2P1	201283	broad.mit.edu	37	17	62968690	62968690	+	RNA	SNP	A	A	G	rs138671696	by1000genomes	TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr17:62968690A>G	ENST00000430983.1	-	0	1554					NR_026903.1																						AAAATTCCACAAGTCTCTTGG	0.373000													4	123					0	0	1	0	0
NADSYN1	55191	broad.mit.edu	37	11	71201984	71201984	+	Missense_Mutation	SNP	G	G	C			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr11:71201984G>C	ENST00000319023.2	+	17	1844	c.1656G>C	c.(1654-1656)caG>caC	p.Q552H	NADSYN1_ENST00000539574.1_Missense_Mutation_p.Q292H|NADSYN1_ENST00000530055.1_Missense_Mutation_p.Q181H	NM_018161.4	NP_060631.2	Q6IA69	NADE_HUMAN	NAD synthetase 1	552	Ligase (By similarity).				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	25					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CCTTCGTCCAGTTCTGCATCC	0.647000													33	202					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	129558816	129558816	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr12:129558816G>T	ENST00000422113.2	-	9	3230	c.2904C>A	c.(2902-2904)agC>agA	p.S968R	TMEM132D_ENST00000389441.4_Missense_Mutation_p.S506R	NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	968						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		CTGTCCGGTTGCTTAACCCAA	0.463000													102	4					3.44186e-60	3.83298e-60	1	1	0
CCDC87	55231	broad.mit.edu	37	11	66359321	66359321	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr11:66359321G>A	ENST00000333861.3	-	1	1233	c.1166C>T	c.(1165-1167)cCa>cTa	p.P389L		NM_018219.2	NP_060689.2	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	389										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						CCCTGCAGCTGGGTGACGGGT	0.592000													164	40					0	0	1	0	0
MYO10	4651	broad.mit.edu	37	5	16699620	16699620	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr5:16699620delC	ENST00000513610.1	-	26	3949	c.3495delG	c.(3493-3495)cgfs	p.R1166fs	MYO10_ENST00000515803.1_Frame_Shift_Del_p.R505fs|MYO10_ENST00000505695.1_Frame_Shift_Del_p.R505fs|MYO10_ENST00000427430.2_Frame_Shift_Del_p.R523fs|MYO10_ENST00000274203.9_Frame_Shift_Del_p.R523fs	NM_012334.2	NP_036466.2	Q9HD67	MYO10_HUMAN	myosin X	1166					axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|lung(28)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	86						CAGAGTCACGCCGGTATGAAA	0.498													32	57	---	---	---	---					
FYN	2534	broad.mit.edu	37	6	111983042	111983042	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr6:111983042delT	ENST00000354650.3	-	14	2120	c.1514delA	c.(1513-1515)agfs	p.K505fs	FYN_ENST00000229470.5_Frame_Shift_Del_p.K453fs|FYN_ENST00000368678.4_Frame_Shift_Del_p.K502fs|FYN_ENST00000356013.2_Frame_Shift_Del_p.K450fs|FYN_ENST00000229471.4_Frame_Shift_Del_p.K450fs|FYN_ENST00000538466.1_Frame_Shift_Del_p.K502fs|FYN_ENST00000368667.2_Frame_Shift_Del_p.K505fs|FYN_ENST00000368682.3_Frame_Shift_Del_p.K502fs	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	505	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TTCAGGGTCCTTTTTCCAGCA	0.562													7	351	---	---	---	---					
KIAA1462	57608	broad.mit.edu	37	10	30316501	30316503	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr10:30316501_30316503delCTG	ENST00000375377.1	-	3	2675_2677	c.2574_2576delCAG	c.(2572-2577)agt>ag	p.SS858del		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	858	Ser-rich.									breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						ACTCTCCTCActgctgctgctgc	0.571													9	136	---	---	---	---					
GDPD4	220032	broad.mit.edu	37	11	76928312	76928315	+	Splice_Site	DEL	ATCT	ATCT	-			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr11:76928312_76928315delATCT	ENST00000376217.2	-	17	1791_1792	c.1540_splice	c.e17-1	p.514_splice	GDPD4_ENST00000315938.4_3'UTR			Q6W3E5	GDPD4_HUMAN	glycerophosphodiester phosphodiesterase domain containing 4	514					glycerol metabolic process|lipid metabolic process	integral to membrane	glycerophosphodiester phosphodiesterase activity|metal ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(8)|prostate(1)|skin(1)	20						CTATGTGCAAatctatctatctat	0.471													7	296	---	---	---	---					
AMHR2	269	broad.mit.edu	37	12	53818999	53819001	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr12:53818999_53819001delCTG	ENST00000257863.4	+	4	555_557	c.475_477delCTG	c.(475-477)del	p.L162del	AMHR2_ENST00000550311.1_In_Frame_Del_p.L162del|AMHR2_ENST00000379791.3_In_Frame_Del_p.L162del	NM_001164690.1|NM_020547.2	NP_001158162.1|NP_065434.1	Q16671	AMHR2_HUMAN	anti-Mullerian hormone receptor, type II	162					Mullerian duct regression		ATP binding|hormone binding|metal ion binding			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|skin(2)	34					Adenosine triphosphate(DB00171)	CCTCCTCCTCCTGCTGCTGCTGG	0.591													7	215	---	---	---	---					
CEP290	80184	broad.mit.edu	37	12	88487681	88487681	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr12:88487681delT	ENST00000552810.1	-	28	3518	c.3175delA	c.(3175-3177)tafs	p.I1059fs	CEP290_ENST00000397838.3_Frame_Shift_Del_p.I119fs|CEP290_ENST00000309041.7_Frame_Shift_Del_p.I1061fs|CEP290_ENST00000547691.2_Frame_Shift_Del_p.I119fs	NM_025114.3	NP_079390.3	O15078	CE290_HUMAN	centrosomal protein 290kDa	1059					cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|liver(1)|lung(18)|ovary(5)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	73						AGCATAGTTATTTTTTTTGAA	0.338													7	46	---	---	---	---					
LOC102725022	102725022	broad.mit.edu	37	15	31508534	31508536	+	RNA	DEL	GGA	GGA	-			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr15:31508534_31508536delGGA	ENST00000559292.2	+	0	18																											aggagcggtgggaggaggaggag	0.660													2	4	---	---	---	---					
RP11-519G16.3	0	broad.mit.edu	37	15	45756158	45756158	+	RNA	DEL	T	T	-	rs143709087		TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr15:45756158delT	ENST00000560077.1	+	0	41				RP11-519G16.3_ENST00000558536.1_RNA|RP11-519G16.3_ENST00000560647.1_RNA																							accaccaccatcaccatcacc	0.567													2	4	---	---	---	---					
RP11-420N3.2	0	broad.mit.edu	37	16	6033900	6033902	+	RNA	DEL	CTC	CTC	-			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr16:6033900_6033902delCTC	ENST00000569895.1	+	0	436																											cctcctcgttctcctcctcctcc	0.581													2	4	---	---	---	---					
VPS53	55275	broad.mit.edu	37	17	465775	465775	+	Frame_Shift_Del	DEL	G	G	-	rs2075443	byFrequency	TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr17:465775delG	ENST00000437048.2	-	14	1670	c.1524delC	c.(1522-1524)tafs	p.Y508fs	VPS53_ENST00000571805.1_Frame_Shift_Del_p.Y508fs|VPS53_ENST00000574029.1_Intron|VPS53_ENST00000401468.3_Frame_Shift_Del_p.Y231fs|VPS53_ENST00000291074.5_Frame_Shift_Del_p.Y479fs|VPS53_ENST00000576149.1_5'UTR|VPS53_ENST00000446250.2_Frame_Shift_Del_p.Y310fs	NM_001128159.2	NP_001121631.1	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 homolog (S. cerevisiae)	508					protein transport	endosome membrane|Golgi apparatus				breast(1)|endometrium(4)|large_intestine(5)|lung(8)|prostate(1)	19				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		TTTTCCAGGCGTATTCTCGGA	0.483													58	57	---	---	---	---					
AC004231.2	0	broad.mit.edu	37	17	39098845	39098846	+	RNA	INS	-	-	TCT	rs149995604	by1000genomes	TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr17:39098845_39098846insTCT	ENST00000418393.1	+	0	385																											cctcctcctcctcttcttctcc	0.515													4	2	---	---	---	---					
LOC101927755	101927755	broad.mit.edu	37	17	58066608	58066608	+	RNA	DEL	T	T	-			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr17:58066608delT	ENST00000586209.1	+	0	158																											TTGATTGTGATTTTTTTTTTT	0.313													3	2	---	---	---	---					
NWD1	284434	broad.mit.edu	37	19	16908642	16908642	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ER-A3ES-06A-11D-A20D-08	TCGA-ER-A3ES-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	73914542-306e-4dfb-a6d2-538baa7344f2	61178f55-37d8-4c86-b1f3-3480d4f7a494	g.chr19:16908642delT	ENST00000524140.2	+	16	3822	c.3404delT	c.(3403-3405)gtfs	p.V1135fs	NWD1_ENST00000552788.1_Frame_Shift_Del_p.V1135fs|NWD1_ENST00000549814.1_Frame_Shift_Del_p.V1135fs|NWD1_ENST00000523826.1_Frame_Shift_Del_p.V929fs|NWD1_ENST00000379808.3_Frame_Shift_Del_p.V1135fs|NWD1_ENST00000339803.6_Frame_Shift_Del_p.V1000fs	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	1135							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						GAGACGGCTGTTTTTGGTACT	0.552													7	554	---	---	---	---					
