Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KIT	3815	broad.mit.edu	37	4	55594221	55594221	+	Missense_Mutation	SNP	A	A	G	rs121913512		TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr4:55594221A>G	ENST00000288135.5	+	13	2021	c.1924A>G	c.(1924-1926)Aaa>Gaa	p.K642E		NM_000222.2|NM_001093772.1	NP_000213.1|NP_001087241.1	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	642	Protein kinase.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity	p.K642E(25)|p.K642Q(1)		NS(8)|autonomic_ganglia(1)|bone(21)|breast(2)|central_nervous_system(4)|endometrium(10)|eye(12)|genital_tract(18)|haematopoietic_and_lymphoid_tissue(1820)|kidney(17)|large_intestine(17)|lung(27)|ovary(23)|pancreas(4)|prostate(1)|salivary_gland(15)|skin(228)|soft_tissue(4117)|stomach(3)|testis(55)|thymus(7)|upper_aerodigestive_tract(1)	6411	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	GTCTGAACTCAAAGTCCTGAG	0.438000		1	"""Mis, O"""		"""GIST, AML, TGCT, mastocytosis, mucosal melanoma"""	"""GIST, epithelioma"""	Piebald trait		Piebaldism;Mast Cell disease, Familial Clustering of;Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Gastrointestinal Stromal Tumors				158	5					0	0	1	0	0
ZBBX	79740	broad.mit.edu	37	3	167039974	167039974	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr3:167039974G>T	ENST00000392766.2	-	12	1254	c.914C>A	c.(913-915)cCa>cAa	p.P305Q	ZBBX_ENST00000307529.5_Missense_Mutation_p.P305Q|ZBBX_ENST00000392767.2_Missense_Mutation_p.P305Q|ZBBX_ENST00000455345.2_Missense_Mutation_p.P305Q|ZBBX_ENST00000469220.1_Intron|ZBBX_ENST00000392764.1_Missense_Mutation_p.P276Q	NM_001199201.1|NM_024687.3	NP_001186130.1|NP_078963.2	A8MT70	ZBBX_HUMAN	zinc finger, B-box domain containing	305						intracellular	zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(5)|large_intestine(9)|liver(1)|lung(38)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	70						AATATTAAGTGGTTCTCTCCA	0.279000													40	53					9.62906e-15	1.0592e-14	1	1	0
DNAJC17	55192	broad.mit.edu	37	15	41060197	41060197	+	Missense_Mutation	SNP	C	C	T	rs142251536	byFrequency	TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr15:41060197C>T	ENST00000220496.4	-	11	886	c.856G>A	c.(856-858)Gag>Aag	p.E286K	DNAJC17_ENST00000558727.1_5'UTR	NM_018163.2	NP_060633.1	Q9NVM6	DJC17_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 17	286					protein folding		heat shock protein binding|nucleotide binding|RNA binding|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(2)|pancreas(1)|skin(1)	6		all_cancers(109;4.16e-14)|all_epithelial(112;9.68e-12)|Lung NSC(122;3.19e-09)|all_lung(180;6.45e-08)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.91e-05)|COAD - Colon adenocarcinoma(120;0.153)|BRCA - Breast invasive adenocarcinoma(123;0.166)		TGTTGCCGCTCGGCCGCCTGG	0.652000													17	19					0	0	1	0	0
IQSEC1	9922	broad.mit.edu	37	3	12978085	12978085	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr3:12978085C>T	ENST00000273221.4	-	3	689	c.473G>A	c.(472-474)cGc>cAc	p.R158H	IQSEC1_ENST00000473088.1_5'UTR	NM_014869.5	NP_055684.3	Q6DN90	IQEC1_HUMAN	IQ motif and Sec7 domain 1	158	IQ.				regulation of ARF protein signal transduction	cytoplasm|nucleus	ARF guanyl-nucleotide exchange factor activity			breast(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CATGGAGCTGCGCAAGCGCTC	0.582000													6	14					0	0	1	0	0
GPA33	10223	broad.mit.edu	37	1	167042719	167042719	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr1:167042719G>A	ENST00000367868.3	-	2	444	c.101C>T	c.(100-102)tCg>tTg	p.S34L	GPA33_ENST00000527955.1_5'UTR	NM_005814.1	NP_005805.1	Q99795	GPA33_HUMAN	glycoprotein A33 (transmembrane)	34	Ig-like V-type.					integral to plasma membrane	receptor activity			endometrium(4)|large_intestine(1)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	15						CTTTCCCTGCGAAGCCCGAAG	0.542000													21	56					0	0	1	0	0
DDI1	414301	broad.mit.edu	37	11	103908451	103908451	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr11:103908451C>T	ENST00000302259.3	+	1	1144	c.901C>T	c.(901-903)Cgt>Tgt	p.R301C	PDGFD_ENST00000302251.5_Intron|PDGFD_ENST00000393158.2_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	301					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		AATTATTGGCCGTGTTCATCT	0.483000													59	88					0	0	1	0	0
GANC	2595	broad.mit.edu	37	15	42631976	42631976	+	Silent	SNP	G	G	A	rs35039186	byFrequency	TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr15:42631976G>A	ENST00000318010.8	+	17	2193	c.1953G>A	c.(1951-1953)aaG>aaA	p.K651K		NM_198141.2	NP_937784.2	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	651					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity	p.K651K(1)		breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		TGAACACCAAGCGACGAGAGC	0.572000													4	46					0	0	1	0	0
ATP2B2	491	broad.mit.edu	37	3	10452485	10452485	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr3:10452485C>T	ENST00000397077.1	-	5	789	c.214G>A	c.(214-216)Gct>Act	p.A72T	ATP2B2_ENST00000383800.4_Missense_Mutation_p.A72T|ATP2B2_ENST00000360273.2_Missense_Mutation_p.A72T|ATP2B2_ENST00000352432.4_Missense_Mutation_p.A72T|ATP2B2_ENST00000343816.4_Missense_Mutation_p.A72T			Q01814	AT2B2_HUMAN	ATPase, Ca++ transporting, plasma membrane 2	72					ATP biosynthetic process|cytosolic calcium ion homeostasis|platelet activation	cytosol|integral to membrane|plasma membrane	ATP binding|calcium ion binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|PDZ domain binding|protein C-terminus binding			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(7)|large_intestine(19)|lung(29)|ovary(5)|prostate(2)|skin(4)|stomach(2)|urinary_tract(2)	74						AGGTCTGGAGCGGTGCCCGGC	0.532000													120	96					0	0	1	0	0
CNOT1	23019	broad.mit.edu	37	16	58568105	58568105	+	Silent	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr16:58568105C>T	ENST00000317147.5	-	40	6173	c.5841G>A	c.(5839-5841)gtG>gtA	p.V1947V	CNOT1_ENST00000245138.4_Silent_p.V798V|CNOT1_ENST00000569240.1_Silent_p.V1942V	NM_001265612.1|NM_016284.4	NP_001252541.1|NP_057368.3	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1947					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				breast(1)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(24)|lung(25)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(2)	87				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		CTGAGTGTTTCACGAGCAGTG	0.502000													32	20					0	0	1	0	0
SLC7A1	6541	broad.mit.edu	37	13	30097603	30097603	+	Silent	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr13:30097603C>T	ENST00000380752.5	-	7	1235	c.849G>A	c.(847-849)caG>caA	p.Q283Q		NM_003045.4	NP_003036.1	P30825	CTR1_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 1	283					cellular nitrogen compound metabolic process|ion transport	integral to plasma membrane	receptor activity			endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|stomach(1)|urinary_tract(2)	24		Lung SC(185;0.0257)|Breast(139;0.238)		all cancers(112;0.0148)|OV - Ovarian serous cystadenocarcinoma(117;0.0554)|Epithelial(112;0.0875)|GBM - Glioblastoma multiforme(144;0.179)	L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GGATGGCCTTCTGTGGGTTCT	0.592000													15	19					0	0	1	0	0
DMTF1	9988	broad.mit.edu	37	7	86803974	86803974	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr7:86803974C>T	ENST00000394703.5	+	9	1071	c.508C>T	c.(508-510)Cgc>Tgc	p.R170C	DMTF1_ENST00000414194.2_5'UTR|DMTF1_ENST00000411766.2_Missense_Mutation_p.R129C|DMTF1_ENST00000394702.3_Missense_Mutation_p.R170C|DMTF1_ENST00000413276.2_Missense_Mutation_p.R170C|DMTF1_ENST00000331242.7_Missense_Mutation_p.R170C|DMTF1_ENST00000432937.2_Missense_Mutation_p.R82C	NM_021145.3	NP_066968.3	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	170	Interaction with CCND2 (By similarity).|Required for DNA-binding (By similarity).|Required for transcriptional activation (By similarity).				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)	16	Esophageal squamous(14;0.0058)					CAATATTGAACGCTATCTTAA	0.303000													32	90					0	0	1	0	0
CENPE	1062	broad.mit.edu	37	4	104062046	104062046	+	Missense_Mutation	SNP	A	A	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr4:104062046A>T	ENST00000265148.3	-	36	5768	c.5679T>A	c.(5677-5679)aaT>aaA	p.N1893K	CENPE_ENST00000380026.3_Missense_Mutation_p.N1868K	NM_001813.2	NP_001804.2	Q02224	CENPE_HUMAN	centromere protein E, 312kDa	1893					blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			NS(3)|breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(20)|lung(34)|ovary(5)|pancreas(1)|prostate(2)|skin(3)|stomach(5)|urinary_tract(3)	101				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		CTCTTCTTAGATTATCTCTTT	0.363000													73	3					0	0	1	0	0
ME1	4199	broad.mit.edu	37	6	83926315	83926315	+	Splice_Site	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr6:83926315C>T	ENST00000369705.3	-	13	1566	c.1449_splice	c.e13-1	p.V484_splice	ME1_ENST00000543031.1_Splice_Site_p.V409_splice|ME1_ENST00000541327.1_Splice_Site_p.V318_splice	NM_002395.4	NP_002386.1	P48163	MAOX_HUMAN	malic enzyme 1, NADP(+)-dependent, cytosolic	484					carbohydrate metabolic process|cellular lipid metabolic process|malate metabolic process|NADP biosynthetic process|response to carbohydrate stimulus|response to hormone stimulus	cytosol	ADP binding|electron carrier activity|malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity|manganese ion binding|NAD binding|NADP binding			NS(2)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	36		all_cancers(76;1.28e-06)|Acute lymphoblastic leukemia(125;5.03e-07)|all_hematologic(105;0.000238)|all_epithelial(107;0.00218)		BRCA - Breast invasive adenocarcinoma(397;0.0641)	NADH(DB00157)	TGAGCTATAACCTTATGAAAA	0.358000													21	20					0	0	1	0	0
DAAM2	23500	broad.mit.edu	37	6	39835373	39835373	+	Silent	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr6:39835373C>T	ENST00000538976.1	+	6	698	c.516C>T	c.(514-516)cgC>cgT	p.R172R	DAAM2_ENST00000398904.2_Silent_p.R172R|DAAM2_ENST00000274867.4_Silent_p.R172R	NM_015345.3	NP_056160.2	Q86T65	DAAM2_HUMAN	dishevelled associated activator of morphogenesis 2	172	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(18)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)	49	Ovarian(28;0.0355)|Colorectal(47;0.196)					GTGAGAGCCGCATCCACACCT	0.552000													18	161					0	0	1	0	0
MAPK7	5598	broad.mit.edu	37	17	19284792	19284792	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr17:19284792G>T	ENST00000308406.5	+	4	1656	c.1270G>T	c.(1270-1272)Gct>Tct	p.A424S	MAPK7_ENST00000571657.1_Intron|MAPK7_ENST00000395602.4_Missense_Mutation_p.A424S|MAPK7_ENST00000299612.7_Missense_Mutation_p.A285S|MAPK7_ENST00000395604.3_Missense_Mutation_p.A424S	NM_139033.2	NP_620602.2	Q13164	MK07_HUMAN	mitogen-activated protein kinase 7	424	May not be required for kinase activity; required to stimulate MEF2C activity (By similarity).|Pro-rich.				cell cycle|cell differentiation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase activity|protein binding			autonomic_ganglia(1)|central_nervous_system(4)|endometrium(5)|kidney(2)|large_intestine(4)|lung(9)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	30	all_cancers(12;2.87e-05)|all_epithelial(12;0.00114)|Hepatocellular(7;0.00345)|Breast(13;0.206)					CAGTCCCTGGGCTCCCAGTGG	0.632000													11	46					9.70103e-10	1.00042e-09	1	1	0
MRPS7	51081	broad.mit.edu	37	17	73258479	73258479	+	Silent	SNP	C	C	T	rs6501772	by1000genomes	TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr17:73258479C>T	ENST00000579002.1	+	1	487	c.72C>T	c.(70-72)tcC>tcT	p.S24S	MRPS7_ENST00000245539.6_Intron|MRPS7_ENST00000579761.1_Intron			Q9Y2R9	RT07_HUMAN	mitochondrial ribosomal protein S7	0					translation	cytosolic small ribosomal subunit|mitochondrion	protein binding|RNA binding|structural constituent of ribosome			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(2)	6	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			CGCGCCGCTCCCCCTCGTCGG	0.597000													4	57					0	0	1	0	0
CDIP1	29965	broad.mit.edu	37	16	4564112	4564112	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr16:4564112G>A	ENST00000399599.3	-	2	568	c.20C>T	c.(19-21)cCt>cTt	p.P7L	CDIP1_ENST00000562334.1_Missense_Mutation_p.P7L|CDIP1_ENST00000563332.2_Missense_Mutation_p.P7L|CDIP1_ENST00000563507.1_Missense_Mutation_p.P7L|CDIP1_ENST00000564828.1_Intron|CDIP1_ENST00000567695.1_Missense_Mutation_p.P7L					cell death-inducing p53 target 1																		AGGATAAGGAGGGGGAGGCTC	0.597000													3	14					0	0	1	0	0
SLC20A2	6575	broad.mit.edu	37	8	42320573	42320573	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr8:42320573A>G	ENST00000342228.3	-	4	835	c.466T>C	c.(466-468)Ttc>Ctc	p.F156L	SLC20A2_ENST00000520179.1_Missense_Mutation_p.F156L|SLC20A2_ENST00000520262.1_Missense_Mutation_p.F156L	NM_006749.4	NP_006740.1	Q08357	S20A2_HUMAN	solute carrier family 20 (phosphate transporter), member 2	156					interspecies interaction between organisms	integral to plasma membrane|membrane fraction	inorganic phosphate transmembrane transporter activity|receptor activity|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity			breast(1)|endometrium(6)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|stomach(1)	26	all_lung(13;8.33e-12)|Lung NSC(13;1.41e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.211)	all_lung(54;0.00671)|Lung NSC(58;0.0184)|Esophageal squamous(32;0.131)|Hepatocellular(245;0.133)|Renal(179;0.151)	BRCA - Breast invasive adenocarcinoma(8;5.73e-10)|OV - Ovarian serous cystadenocarcinoma(14;0.00419)|Lung(22;0.0302)|LUSC - Lung squamous cell carcinoma(45;0.0869)			CCAGACATGAAACCAGACAAC	0.303000													23	81					0	0	1	0	0
PLA2G5	5322	broad.mit.edu	37	1	20412607	20412607	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr1:20412607C>G	ENST00000375108.3	+	3	340	c.72C>G	c.(70-72)gaC>gaG	p.D24E	PLA2G5_ENST00000486277.1_3'UTR	NM_000929.2	NP_000920.1	P39877	PA2G5_HUMAN	phospholipase A2, group V	24					lipid catabolic process	extracellular region	calcium ion binding|calcium-dependent phospholipase A2 activity			NS(1)|large_intestine(1)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000249)|Lung NSC(340;0.000287)|Breast(348;0.000812)|Ovarian(437;0.00328)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(152;1.22e-05)|BRCA - Breast invasive adenocarcinoma(304;8.15e-05)|Kidney(64;0.000184)|GBM - Glioblastoma multiforme(114;0.00089)|KIRC - Kidney renal clear cell carcinoma(64;0.0027)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0652)		GCTTGCTGGACCTAAAATCAA	0.602000													21	26					0	0	1	0	0
CCR3	1232	broad.mit.edu	37	3	46307516	46307516	+	Silent	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr3:46307516C>T	ENST00000357422.2	+	4	1410	c.867C>T	c.(865-867)atC>atT	p.I289I	CCR3_ENST00000395942.2_Silent_p.I289I|CCR3_ENST00000545097.1_Silent_p.I310I|CCR3_ENST00000541018.1_Silent_p.I289I|CCR3_ENST00000395940.2_Silent_p.I289I			P51677	CCR3_HUMAN	chemokine (C-C motif) receptor 3	289					cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(3)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CAGAGGTGATCGCCTACTCCC	0.522000													22	57					0	0	1	0	0
OR1D4	653166	broad.mit.edu	37	17	3144312	3144312	+	RNA	SNP	C	C	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr17:3144312C>A	ENST00000531680.1	+	0	343					NR_033795.1				olfactory receptor, family 1, subfamily D, member 4 (gene/pseudogene)																		CAACCTCATCCTGGCCGTGAT	0.567000													19	53					7.92952e-12	8.35131e-12	1	1	0
CPAMD8	27151	broad.mit.edu	37	19	17122306	17122306	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr19:17122306C>T	ENST00000443236.1	-	5	626	c.595G>A	c.(595-597)Gtc>Atc	p.V199I	CPAMD8_ENST00000388925.4_Missense_Mutation_p.V152I|CTD-2528A14.1_ENST00000595134.1_RNA	NM_015692.2	NP_056507.2	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain containing 8	152						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(14)|ovary(7)|pancreas(2)|prostate(4)|skin(5)	82						TTTGGAGAGACGGTGAAGATG	0.587000													80	61					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9090379	9090379	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr19:9090379G>T	ENST00000397910.4	-	1	1639	c.1436C>A	c.(1435-1437)cCa>cAa	p.P479Q		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	479	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCTCTTGTTGGGTGGGATGA	0.552000													36	153					6.84511e-11	7.13333e-11	1	1	0
LIPG	9388	broad.mit.edu	37	18	47095863	47095863	+	Silent	SNP	G	G	C			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr18:47095863G>C	ENST00000261292.4	+	4	794	c.516G>C	c.(514-516)gcG>gcC	p.A172A	LIPG_ENST00000577628.1_Silent_p.A208A|LIPG_ENST00000580036.1_Silent_p.A172A|LIPG_ENST00000427224.2_Silent_p.A172A	NM_006033.2	NP_006024.1	Q9Y5X9	LIPE_HUMAN	lipase, endothelial	172					cholesterol homeostasis|high-density lipoprotein particle remodeling|phospholipid catabolic process|phospholipid homeostasis|positive regulation of cholesterol transport|positive regulation of high-density lipoprotein particle clearance|reverse cholesterol transport	extracellular space	heparin binding|lipoprotein lipase activity|phospholipase A1 activity|protein binding|triglyceride lipase activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(1)|prostate(2)|skin(2)	18						GCCTCGGAGCGCACGTGGCCG	0.542000													5	23					0	0	1	0	0
ZNF808	388558	broad.mit.edu	37	19	53056854	53056854	+	Missense_Mutation	SNP	A	A	G			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr19:53056854A>G	ENST00000359798.4	+	5	865	c.685A>G	c.(685-687)Aaa>Gaa	p.K229E		NM_001039886.3	NP_001034975.2	Q8N4W9	ZN808_HUMAN	zinc finger protein 808	229					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(8)|kidney(3)|lung(12)|urinary_tract(1)	24				OV - Ovarian serous cystadenocarcinoma(262;0.00501)|GBM - Glioblastoma multiforme(134;0.0213)		CATGAGAGAAAAATCTTTCCC	0.368000													168	110					0	0	1	0	0
BEND6	221336	broad.mit.edu	37	6	56882033	56882033	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr6:56882033G>A	ENST00000370746.3	+	5	817	c.548G>A	c.(547-549)cGt>cAt	p.R183H	BEND6_ENST00000370750.2_3'UTR|BEND6_ENST00000484701.1_3'UTR|BEND6_ENST00000545789.1_Missense_Mutation_p.R85H	NM_152731.2	NP_689944.2	Q5SZJ8	BEND6_HUMAN	BEN domain containing 6	183	BEN.									endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	17						CAGATTGCCCGTTGTAACAAG	0.363000													6	49					0	0	1	0	0
MARVELD2	153562	broad.mit.edu	37	5	68715411	68715411	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr5:68715411G>T	ENST00000325631.5	+	2	273	c.199G>T	c.(199-201)Gaa>Taa	p.E67*	MARVELD2_ENST00000413223.2_Nonsense_Mutation_p.E67*	NM_001038603.2|NM_001244734.1	NP_001033692.2|NP_001231663.1	Q8N4S9	MALD2_HUMAN	MARVEL domain containing 2	67					sensory perception of sound	integral to membrane|tight junction				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|liver(1)|lung(4)|skin(1)|urinary_tract(1)	15		Lung NSC(167;0.000937)|Prostate(74;0.0187)|Ovarian(174;0.16)		OV - Ovarian serous cystadenocarcinoma(47;7.31e-57)|Epithelial(20;1.05e-52)|all cancers(19;2.63e-48)|Lung(70;0.0183)		AAGTGACACAGAAGAACCAGC	0.532000													45	57					1.41504e-22	1.61021e-22	1	1	0
SASS6	163786	broad.mit.edu	37	1	100568566	100568566	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr1:100568566G>T	ENST00000287482.5	-	14	1759	c.1619C>A	c.(1618-1620)aCc>aAc	p.T540N	SASS6_ENST00000462159.1_5'UTR|SASS6_ENST00000535161.1_Missense_Mutation_p.T373N	NM_194292.1	NP_919268.1	Q6UVJ0	SAS6_HUMAN	spindle assembly 6 homolog (C. elegans)	540					centriole replication	centriole				breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|upper_aerodigestive_tract(2)	19		all_epithelial(167;4.58e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.085)|all cancers(265;0.139)|COAD - Colon adenocarcinoma(174;0.15)|Lung(183;0.197)		ATGAGGGAAGGTATTCTGGAA	0.388000													25	38					1.17739e-12	1.26698e-12	1	1	0
JAKMIP3	282973	broad.mit.edu	37	10	133948572	133948572	+	Silent	SNP	C	C	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr10:133948572C>A	ENST00000298622.4	+	4	1015	c.877C>A	c.(877-879)Cgg>Agg	p.R293R		NM_001105521.2	NP_001098991.1			Janus kinase and microtubule interacting protein 3											breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(2)	31		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		AAAAGATGCCCGGCGCTTCCA	0.502000													38	3					1.04594e-18	1.16346e-18	1	1	0
TCTEX1D1	200132	broad.mit.edu	37	1	67220356	67220356	+	Silent	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr1:67220356C>T	ENST00000282670.2	+	2	143	c.15C>T	c.(13-15)gaC>gaT	p.D5D	TCTEX1D1_ENST00000491611.1_3'UTR	NM_152665.2	NP_689878.2	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	5										large_intestine(2)|lung(10)|skin(1)	13						TGATGTCAGACAATGCTAAAG	0.363000													24	33					0	0	1	0	0
GPRIN3	285513	broad.mit.edu	37	4	90170046	90170046	+	Missense_Mutation	SNP	G	G	A	rs35246727	byFrequency	TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr4:90170046G>A	ENST00000333209.3	-	2	1734	c.1216C>T	c.(1216-1218)Cgg>Tgg	p.R406W		NM_198281.2	NP_938022.2	Q6ZVF9	GRIN3_HUMAN	GPRIN family member 3	406										breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|prostate(2)|skin(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		TTATTTTCCCGTTGGAAAGCT	0.532000													45	119					0	0	1	0	0
CACNA1C	775	broad.mit.edu	37	12	2760808	2760808	+	Silent	SNP	C	C	T	rs150092451	by1000genomes	TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr12:2760808C>T	ENST00000399655.1	+	32	4213	c.3948C>T	c.(3946-3948)aaC>aaT	p.N1316N	CACNA1C_ENST00000399603.1_Silent_p.N1316N|CACNA1C_ENST00000399641.1_Silent_p.N1316N|CACNA1C_ENST00000406454.3_Silent_p.N1316N|CACNA1C_ENST00000402845.3_Silent_p.N1316N|CACNA1C_ENST00000335762.5_Silent_p.N1341N|CACNA1C_ENST00000399617.1_Silent_p.N1316N|CACNA1C_ENST00000399595.1_Silent_p.N1305N|CACNA1C_ENST00000399638.1_Silent_p.N1344N|CACNA1C_ENST00000399591.1_Silent_p.N1305N|CACNA1C_ENST00000399597.1_Silent_p.N1316N|CACNA1C_ENST00000344100.3_Silent_p.N1338N|CACNA1C_ENST00000399637.1_Silent_p.N1316N|CACNA1C_ENST00000399621.1_Silent_p.N1316N|CACNA1C_ENST00000347598.4_Silent_p.N1364N|CACNA1C_ENST00000399629.1_Silent_p.N1333N|CACNA1C_ENST00000399606.1_Silent_p.N1336N|CACNA1C_ENST00000399649.1_Silent_p.N1303N|CACNA1C_ENST00000327702.7_Silent_p.N1316N|CACNA1C_ENST00000399634.1_Silent_p.N1316N|CACNA1C_ENST00000399644.1_Silent_p.N1316N|CACNA1C_ENST00000399601.1_Silent_p.N1316N	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1364					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity	p.N851N(1)|p.N1394N(1)		NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	GGTTCCAGAACGCAGAGGAAA	0.617000													12	68					0	0	1	0	0
TAF5	6877	broad.mit.edu	37	10	105147056	105147056	+	Silent	SNP	C	C	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr10:105147056C>A	ENST00000369839.3	+	9	1977	c.1954C>A	c.(1954-1956)Cgg>Agg	p.R652R	TAF5_ENST00000351396.4_Silent_p.R597R	NM_006951.3	NP_008882.2	Q15542	TAF5_HUMAN	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa	652					histone acetylation|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|transcription factor TFIID complex|transcription factor TFTC complex	protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(5)|lung(4)|ovary(2)	15		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;1.83e-09)|all cancers(201;1.4e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		CAGAACTGTGCGGCTCTGGGA	0.433000													58	3					3.89483e-19	4.38168e-19	1	1	0
MAP2K1	5604	broad.mit.edu	37	15	66729163	66729163	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr15:66729163C>T	ENST00000307102.5	+	3	902	c.371C>T	c.(370-372)cCg>cTg	p.P124L		NM_002755.3	NP_002746.1	Q02750	MP2K1_HUMAN	mitogen-activated protein kinase kinase 1	124	Protein kinase.				activation of MAPK activity|activation of MAPKK activity|axon guidance|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|plasma membrane	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|prostate(1)|skin(8)|urinary_tract(1)	20						TGCAACTCTCCGTACATCGTG	0.512000													40	60					0	0	1	0	0
DCDC2	51473	broad.mit.edu	37	6	24291186	24291186	+	Silent	SNP	G	G	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr6:24291186G>A	ENST00000378454.3	-	5	979	c.678C>T	c.(676-678)gaC>gaT	p.D226D		NM_001195610.1|NM_016356.3	NP_001182539.1|NP_057440.2	Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	226					cellular defense response|intracellular signal transduction|neuron migration					breast(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32		Ovarian(999;0.101)				TCGTTGACTTGTCAAAAAGTA	0.428000													27	58					0	0	1	0	0
BRF1	2972	broad.mit.edu	37	14	105678483	105678483	+	Silent	SNP	A	A	G			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr14:105678483A>G	ENST00000546474.1	-	16	16750	c.1791T>C	c.(1789-1791)tcT>tcC	p.S597S	BRF1_ENST00000379932.4_Intron|BRF1_ENST00000392557.4_Silent_p.S393S|BRF1_ENST00000440513.3_Silent_p.S504S|BRF1_ENST00000379937.2_Silent_p.S570S|BRF1_ENST00000327359.3_Silent_p.S482S|BRF1_ENST00000446501.2_Silent_p.S359S|BRF1_ENST00000551787.1_Intron|BRF1_ENST00000547530.1_Silent_p.S123S	NM_001242787.1|NM_001519.3	NP_001229716.1|NP_001510.2	Q92994	TF3B_HUMAN	BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit	597					positive regulation of transcription, DNA-dependent|rRNA transcription|transcription initiation from RNA polymerase III promoter|tRNA transcription	transcription factor TFIIIB complex	translation initiation factor activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0231)|all_epithelial(191;0.0694)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00753)|all cancers(16;0.00925)|Epithelial(46;0.0221)	Epithelial(152;0.14)		CTGGCTGCGTAGACACCAGAG	0.627000													9	19					0	0	1	0	0
NRXN3	9369	broad.mit.edu	37	14	80164222	80164222	+	Missense_Mutation	SNP	C	C	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr14:80164222C>A	ENST00000281127.7	+	4	1730	c.851C>A	c.(850-852)aCc>aAc	p.T284N	NRXN3_ENST00000557594.1_Missense_Mutation_p.T284N|NRXN3_ENST00000335750.5_Missense_Mutation_p.T916N|RP11-242P2.1_ENST00000553322.1_RNA|NRXN3_ENST00000428277.2_Missense_Mutation_p.T314N|NRXN3_ENST00000554719.1_Missense_Mutation_p.T916N|NRXN3_ENST00000556003.1_Intron	NM_138970.3	NP_620426.2	Q9HDB5	NRX3B_HUMAN	neurexin 3	284					angiogenesis|cell adhesion	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(23)|lung(40)|ovary(3)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(9)|urinary_tract(1)	104		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GTCATGGAAACCACTACTACA	0.448000													37	58					2.6416e-12	2.81203e-12	1	1	0
RBM34	23029	broad.mit.edu	37	1	235301434	235301434	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr1:235301434C>T	ENST00000408888.3	-	7	987	c.757G>A	c.(757-759)Gag>Aag	p.E253K	RBM34_ENST00000366606.3_Missense_Mutation_p.E248K			P42696	RBM34_HUMAN	RNA binding motif protein 34	253	RRM 1.					nucleolus	nucleotide binding|RNA binding			central_nervous_system(1)	1	Ovarian(103;0.0398)	all_cancers(173;0.177)|Prostate(94;0.0166)	OV - Ovarian serous cystadenocarcinoma(106;5.43e-05)|Epithelial(3;0.000121)			GCAGCACTCTCCTCCTTAAAC	0.318000													7	60					0	0	1	0	0
SEC11C	90701	broad.mit.edu	37	18	56819782	56819782	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr18:56819782C>T	ENST00000587834.1	+	3	684	c.212C>T	c.(211-213)cCg>cTg	p.P71L	SEC11C_ENST00000588875.1_Missense_Mutation_p.P71L	NM_033280.2	NP_150596.1	Q9BY50	SC11C_HUMAN	SEC11 homolog C (S. cerevisiae)	71					energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	endoplasmic reticulum membrane|integral to membrane|microsome	serine-type peptidase activity			endometrium(1)|large_intestine(4)|liver(2)|lung(2)	9		Colorectal(73;0.175)				AGTATGGAGCCGGCCTTTCAC	0.453000													77	164					0	0	1	0	0
GPBP1	65056	broad.mit.edu	37	5	56558492	56558492	+	Silent	SNP	G	G	A	rs147297567		TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr5:56558492G>A	ENST00000424459.3	+	13	2669	c.1395G>A	c.(1393-1395)ccG>ccA	p.P465P	GPBP1_ENST00000264779.6_Silent_p.P452P|GPBP1_ENST00000514387.2_Silent_p.P274P|GPBP1_ENST00000538707.1_Silent_p.P452P|GPBP1_ENST00000511209.1_Silent_p.P437P|GPBP1_ENST00000454432.2_Silent_p.P465P|GPBP1_ENST00000506184.2_Silent_p.P445P	NM_022913.3	NP_075064.1	Q86WP2	GPBP1_HUMAN	GC-rich promoter binding protein 1	445					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	19		Lung NSC(810;0.000861)|Prostate(74;0.0305)|Breast(144;0.222)		OV - Ovarian serous cystadenocarcinoma(10;7.64e-39)		AGTTTGGACCGTGGAAGAACA	0.368000													54	65					0	0	1	0	0
SYTL3	94120	broad.mit.edu	37	6	159181747	159181747	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr6:159181747C>T	ENST00000297239.9	+	14	1578	c.1384C>T	c.(1384-1386)Cgg>Tgg	p.R462W	SYTL3_ENST00000360448.3_Missense_Mutation_p.R394W|SYTL3_ENST00000367081.3_Missense_Mutation_p.R188W			Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	462					intracellular protein transport	endomembrane system|membrane	Rab GTPase binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|pancreas(1)|urinary_tract(1)	20		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		TCTCCCTTCACGGCCCAGAAA	0.562000													22	24					0	0	1	0	0
ZNF282	8427	broad.mit.edu	37	7	148921667	148921667	+	Silent	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr7:148921667C>T	ENST00000262085.3	+	8	2049	c.1944C>T	c.(1942-1944)caC>caT	p.H648H	ZNF282_ENST00000479907.1_3'UTR	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	648					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		TCAAGGACCACCTGCGCGTGC	0.726000													6	26					0	0	1	0	0
KIAA1328	57536	broad.mit.edu	37	18	34802054	34802054	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr18:34802054C>T	ENST00000591619.1	+	10	2372	c.1586C>T	c.(1585-1587)tCc>tTc	p.S529F	KIAA1328_ENST00000543923.1_Missense_Mutation_p.S425F|KIAA1328_ENST00000586135.1_3'UTR|KIAA1328_ENST00000280020.5_Missense_Mutation_p.S533F			Q86T90	K1328_HUMAN	KIAA1328	533										central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|skin(2)|upper_aerodigestive_tract(1)	14				COAD - Colon adenocarcinoma(74;0.195)		CGCTATCCCTCCAGAGAAGCT	0.502000													11	11					0	0	1	0	0
ALPK2	115701	broad.mit.edu	37	18	56204417	56204417	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr18:56204417G>A	ENST00000361673.3	-	5	3215	c.3002C>T	c.(3001-3003)gCg>gTg	p.A1001V	RP11-1151B14.4_ENST00000591360.1_RNA	NM_052947.3	NP_443179.3	Q86TB3	ALPK2_HUMAN	alpha-kinase 2	1001							ATP binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(33)|ovary(7)|prostate(1)|skin(10)|upper_aerodigestive_tract(2)	84						CTCCCTGGTCGCTTGAAAGCA	0.488000													8	77					0	0	1	0	0
PRR23A	729627	broad.mit.edu	37	3	138724873	138724873	+	Missense_Mutation	SNP	G	G	C			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr3:138724873G>C	ENST00000383163.2	-	1	237	c.238C>G	c.(238-240)Ctg>Gtg	p.L80V	MRPS22_ENST00000495075.1_5'UTR	NM_001134659.1	NP_001128131.1	A6NEV1	PR23A_HUMAN	proline rich 23A	80										endometrium(3)|kidney(1)|lung(7)	11						GGGAGCTCCAGCACCAGGTCG	0.677000													10	6					0	0	1	0	0
SLC16A5	9121	broad.mit.edu	37	17	73089706	73089706	+	Missense_Mutation	SNP	G	G	A	rs4789134	by1000genomes	TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr17:73089706G>A	ENST00000538213.2	+	2	223	c.95G>A	c.(94-96)aGg>aAg	p.R32K	SLC16A5_ENST00000329783.4_5'UTR|SLC16A5_ENST00000580123.1_5'UTR|SLC16A5_ENST00000450736.2_5'UTR|SLC16A5_ENST00000585293.1_3'UTR			O15375	MOT6_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 5	0					organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	22	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	TTGGCAGTGAGGCCGTGGCAG	0.687000													3	23					0	0	1	0	0
MYH3	4621	broad.mit.edu	37	17	10542464	10542464	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr17:10542464G>T	ENST00000583535.1	-	25	3232	c.3145C>A	c.(3145-3147)Ctg>Atg	p.L1049M	MYH3_ENST00000226209.7_Missense_Mutation_p.L1049M	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1049					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TTCCTTTCCAGGTCTACTCGG	0.453000													19	49					5.3912e-06	5.50236e-06	1	1	0
SULF2	55959	broad.mit.edu	37	20	46313216	46313216	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr20:46313216G>A	ENST00000359930.4	-	6	1698	c.847C>T	c.(847-849)Cgc>Tgc	p.R283C	SULF2_ENST00000467815.1_Missense_Mutation_p.R283C|SULF2_ENST00000361612.4_Missense_Mutation_p.R283C|SULF2_ENST00000484875.1_Missense_Mutation_p.R283C|CTD-2653D5.1_ENST00000526566.2_RNA	NM_018837.3	NP_061325.1	Q8IWU5	SULF2_HUMAN	sulfatase 2	283					bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|endometrium(4)|kidney(1)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	54						GTCTGCAAGCGCTTCCGCTGG	0.627000													16	15					0	0	1	0	0
USP13	8975	broad.mit.edu	37	3	179472600	179472600	+	Missense_Mutation	SNP	C	C	G			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr3:179472600C>G	ENST00000263966.3	+	15	2350	c.1879C>G	c.(1879-1881)Cca>Gca	p.P627A	USP13_ENST00000496897.1_Missense_Mutation_p.P562A|USP13_ENST00000482333.1_3'UTR	NM_003940.2	NP_003931.2	Q92995	UBP13_HUMAN	ubiquitin specific peptidase 13 (isopeptidase T-3)	627					ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|omega peptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	46	all_cancers(143;7.79e-15)|Ovarian(172;0.0338)|Breast(254;0.148)		OV - Ovarian serous cystadenocarcinoma(80;1e-25)|GBM - Glioblastoma multiforme(14;0.0169)			GGAAGAACTTCCAGACATCAG	0.483000													56	81					0	0	1	0	0
PRR14	78994	broad.mit.edu	37	16	30663152	30663152	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr16:30663152T>C	ENST00000542965.2	+	2	515	c.59T>C	c.(58-60)cTg>cCg	p.L20P	PRR14_ENST00000300835.4_Missense_Mutation_p.L20P			Q9BWN1	PRR14_HUMAN	proline rich 14	20										breast(3)|endometrium(5)|kidney(1)|large_intestine(3)|lung(5)|skin(1)	18			Colorectal(24;0.103)			CGCCAGCCTCTGACTCGAGCA	0.687000													27	81					0	0	1	0	0
ZSWIM4	65249	broad.mit.edu	37	19	13910714	13910714	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr19:13910714G>A	ENST00000254323.2	+	2	523	c.334G>A	c.(334-336)Gtg>Atg	p.V112M		NM_023072.2	NP_075560.2	Q9H7M6	ZSWM4_HUMAN	zinc finger, SWIM-type containing 4	112							zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27			OV - Ovarian serous cystadenocarcinoma(19;2.94e-23)|Epithelial(5;4.58e-19)			GAGCGGGGCCGTGGACCGCGT	0.652000													13	43					0	0	1	0	0
PLXNA4	91584	broad.mit.edu	37	7	131859615	131859615	+	Silent	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr7:131859615C>T	ENST00000359827.3	-	21	4901	c.3939G>A	c.(3937-3939)ccG>ccA	p.P1313P	PLXNA4_ENST00000321063.4_Silent_p.P1313P			Q9HCM2	PLXA4_HUMAN	plexin A4	1313						integral to membrane|intracellular|plasma membrane				NS(1)|breast(1)|endometrium(3)|kidney(4)|large_intestine(14)|lung(17)|ovary(1)|prostate(2)|skin(1)|stomach(1)	45						AGTCCAGGAACGGAATCCCGG	0.572000													23	186					0	0	1	0	0
UNC13C	440279	broad.mit.edu	37	15	54803979	54803979	+	Missense_Mutation	SNP	A	A	C			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr15:54803979A>C	ENST00000545554.1	+	23	5408	c.5408A>C	c.(5407-5409)cAa>cCa	p.Q1803P	UNC13C_ENST00000537900.1_Missense_Mutation_p.Q1801P|UNC13C_ENST00000260323.11_Missense_Mutation_p.Q1803P			Q8NB66	UN13C_HUMAN	unc-13 homolog C (C. elegans)	1803					exocytosis|intracellular signal transduction	cell junction|cytoplasm|presynaptic membrane	metal ion binding			breast(3)|endometrium(5)|kidney(5)|large_intestine(20)|lung(70)|ovary(6)|pancreas(2)|prostate(2)|upper_aerodigestive_tract(4)|urinary_tract(4)	121				GBM - Glioblastoma multiforme(80;0.0789)|all cancers(107;0.124)		AATATTCAACAATTGCGGGTC	0.308000													5	28					0	0	1	0	0
STK10	6793	broad.mit.edu	37	5	171509966	171509966	+	Splice_Site	SNP	T	T	G	rs146527200	byFrequency	TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr5:171509966T>G	ENST00000176763.5	-	11	2151	c.1809_splice	c.e11+1	p.N603_splice		NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	603							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CGCACTCACGTTGATTTCCTG	0.502000													6	126					0	0	1	0	0
CHD9	80205	broad.mit.edu	37	16	53243524	53243524	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr16:53243524G>A	ENST00000566029.1	+	3	1792	c.1583G>A	c.(1582-1584)cGt>cAt	p.R528H	CHD9_ENST00000398510.3_Missense_Mutation_p.R528H|CHD9_ENST00000564845.1_Missense_Mutation_p.R528H|CHD9_ENST00000447540.1_Missense_Mutation_p.R528H			Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	528					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(32)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	78		all_cancers(37;0.0212)				AAGGCTAATCGTATAATATCA	0.438000													42	51					0	0	1	0	0
B2M	567	broad.mit.edu	37	15	45003745	45003745	+	Translation_Start_Site	SNP	A	A	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr15:45003745A>T	ENST00000558401.1	+	1	71	c.1A>T	c.(1-3)Atg>Ttg	p.M1L	B2M_ENST00000544417.1_Start_Codon_SNP_p.M1L|B2M_ENST00000559916.1_Start_Codon_SNP_p.M1L	NM_004048.2	NP_004039.1	P61769	B2MG_HUMAN	beta-2-microglobulin	1					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding	p.M1L(3)|p.M1V(2)|p.?(1)		breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(30)|kidney(8)|large_intestine(6)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	59		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		TCGGGCCGAGATGTCTCGCTC	0.612000													38	34					0	0	1	0	0
UBAP2	55833	broad.mit.edu	37	9	33944587	33944587	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr9:33944587G>A	ENST00000379238.1	-	14	1438	c.1321C>T	c.(1321-1323)Cga>Tga	p.R441*	UBAP2_ENST00000418786.2_Nonsense_Mutation_p.R388*|UBAP2_ENST00000539807.1_Nonsense_Mutation_p.R196*|UBAP2_ENST00000379225.1_Nonsense_Mutation_p.R74*|UBAP2_ENST00000379239.4_Nonsense_Mutation_p.R174*|UBAP2_ENST00000360802.1_Nonsense_Mutation_p.R441*|UBAP2_ENST00000449054.1_Nonsense_Mutation_p.R441*			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	441										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		TGCTGTTGTCGCTGGCTCAAC	0.483000													24	1					0	0	1	0	0
USP20	10868	broad.mit.edu	37	9	132637641	132637641	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr9:132637641G>A	ENST00000315480.4	+	20	2259	c.2101G>A	c.(2101-2103)Gcc>Acc	p.A701T	USP20_ENST00000372429.3_Missense_Mutation_p.A701T|USP20_ENST00000358355.1_Missense_Mutation_p.A701T			Q9Y2K6	UBP20_HUMAN	ubiquitin specific peptidase 20	701	DUSP 1.				endocytosis|protein K48-linked deubiquitination|protein K63-linked deubiquitination|regulation of G-protein coupled receptor protein signaling pathway|ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	cysteine-type endopeptidase activity|G-protein-coupled receptor binding|ubiquitin thiolesterase activity|zinc ion binding			breast(1)|endometrium(2)|large_intestine(3)|lung(4)|urinary_tract(1)	11		Ovarian(14;0.00556)				GTCCCTGGCCGCCATGCGGGA	0.662000													19	15					0	0	1	0	0
VPS4A	27183	broad.mit.edu	37	16	69354045	69354045	+	Splice_Site	SNP	C	C	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr16:69354045C>A	ENST00000254950.11	+	7	778	c.620_splice	c.e7-1	p.L208_splice	COG8_ENST00000564419.1_5'UTR|RP11-343C2.3_ENST00000570054.2_Splice_Site_p.L232_splice|VPS4A_ENST00000569775.1_Intron	NM_013245.2	NP_037377.1	Q9UN37	VPS4A_HUMAN	vacuolar protein sorting 4 homolog A (S. cerevisiae)	208					cell cycle|cellular membrane organization|cytokinesis|endosome transport|protein transport	cytosol|late endosome membrane|midbody|perinuclear region of cytoplasm	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein domain specific binding			NS(1)|central_nervous_system(1)|large_intestine(2)|lung(3)	7		Ovarian(137;0.101)				CCTTCACAGGCTGGTCAAGAA	0.592000													6	12					8.12818e-05	8.12818e-05	1	1	0
CES3	23491	broad.mit.edu	37	16	67000765	67000765	+	Silent	SNP	C	C	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr16:67000765C>A	ENST00000303334.4	+	8	1130	c.1059C>A	c.(1057-1059)ccC>ccA	p.P353P	CES3_ENST00000394037.1_Silent_p.P353P	NM_024922.5	NP_079198.2	Q6UWW8	EST3_HUMAN	carboxylesterase 3	353						endoplasmic reticulum lumen	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(4)|lung(6)|ovary(3)|skin(1)	24		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0488)|Epithelial(162;0.127)		GGCTCATCCCCAGGGTGAGTT	0.592000													58	76					3.76997e-23	4.33985e-23	1	1	0
GNAQ	2776	broad.mit.edu	37	9	80537210	80537210	+	Missense_Mutation	SNP	T	T	C			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr9:80537210T>C	ENST00000286548.4	-	2	410	c.188A>G	c.(187-189)cAt>cGt	p.H63R		NM_002072.3	NP_002063.2	P50148	GNAQ_HUMAN	guanine nucleotide binding protein (G protein), q polypeptide	63					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity by dopamine receptor signaling pathway|glutamate signaling pathway|negative regulation of protein kinase activity|platelet activation|protein ADP-ribosylation|protein stabilization|regulation of action potential|regulation of catenin import into nucleus	cytoplasm|heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activator activity|GTPase activity|signal transducer activity			NS(1)|endometrium(3)|eye(229)|kidney(1)|large_intestine(4)|lung(6)|meninges(11)|ovary(1)|prostate(1)|skin(44)|upper_aerodigestive_tract(1)	302						TCCTGACCCATGGATGATTCT	0.483000			Mis		uveal melanoma								27	91					0	0	1	0	0
PRKCG	5582	broad.mit.edu	37	19	54385775	54385775	+	Silent	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr19:54385775C>T	ENST00000263431.3	+	1	309	c.27C>T	c.(25-27)ggC>ggT	p.G9G	PRKCG_ENST00000540413.1_Silent_p.G9G|PRKCG_ENST00000536044.1_Silent_p.G9G	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	9					activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		CCGGCGTAGGCGATTCAGAGG	0.627000													61	130					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32631137	32631137	+	Missense_Mutation	SNP	G	G	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr9:32631137G>A	ENST00000242310.4	-	1	4530	c.4441C>T	c.(4441-4443)Cca>Tca	p.P1481S		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1481	Bromo 1.				male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GAATGTTTTGGCCCATTGTAG	0.418000													59	43					0	0	1	0	0
PREPL	9581	broad.mit.edu	37	2	44549983	44549983	+	Nonsense_Mutation	SNP	G	G	C			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr2:44549983G>C	ENST00000541738.1	-	12	2026	c.1640C>G	c.(1639-1641)tCa>tGa	p.S547*	PREPL_ENST00000409411.1_Nonsense_Mutation_p.S547*|PREPL_ENST00000378520.3_Nonsense_Mutation_p.S570*|PREPL_ENST00000260648.6_Nonsense_Mutation_p.S636*|PREPL_ENST00000409936.1_Nonsense_Mutation_p.S636*|PREPL_ENST00000410081.1_Nonsense_Mutation_p.S636*|PREPL_ENST00000409957.1_Nonsense_Mutation_p.S547*|PREPL_ENST00000378511.3_Nonsense_Mutation_p.S574*|PREPL_ENST00000409272.1_Nonsense_Mutation_p.S636*	NM_001171617.1	NP_001165088.1	Q4J6C6	PPCEL_HUMAN	prolyl endopeptidase-like	636					proteolysis	cytosol	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(19)|ovary(1)|prostate(1)|skin(2)	33		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TATGTGAATTGAAGGATAATG	0.373000													64	82					0	0	1	0	0
NPEPL1	79716	broad.mit.edu	37	20	57288496	57288496	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr20:57288496C>T	ENST00000356091.6	+	9	1310	c.1022C>T	c.(1021-1023)aCg>aTg	p.T341M	NPEPL1_ENST00000525967.1_Missense_Mutation_p.T313M|NPEPL1_ENST00000525817.1_Missense_Mutation_p.T293M|STX16-NPEPL1_ENST00000530122.1_3'UTR	NM_024663.3	NP_078939.3	Q8NDH3	PEPL1_HUMAN	aminopeptidase-like 1	341					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)	14	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			ATCAACAACACGGATGCCGAG	0.622000													4	7					0	0	1	0	0
ZNF862	643641	broad.mit.edu	37	7	149545315	149545315	+	Missense_Mutation	SNP	C	C	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr7:149545315C>A	ENST00000223210.4	+	4	978	c.733C>A	c.(733-735)Cca>Aca	p.P245T		NM_001099220.1	NP_001092690.1	O60290	ZN862_HUMAN	zinc finger protein 862	245					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|nucleic acid binding|protein dimerization activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|skin(1)	34						ATTCTACCCCCCAGGGCCTCT	0.587000													26	11					9.39395e-14	1.02198e-13	1	1	0
ARID4B	51742	broad.mit.edu	37	1	235338527	235338527	+	Silent	SNP	G	G	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr1:235338527G>A	ENST00000264183.3	-	22	4133	c.3636C>T	c.(3634-3636)ccC>ccT	p.P1212P	ARID4B_ENST00000366603.2_Silent_p.P1212P|ARID4B_ENST00000349213.3_Silent_p.P1126P	NM_016374.5	NP_057458.4	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B (RBP1-like)	1212					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			NS(1)|breast(2)|large_intestine(2)|lung(1)|ovary(2)	8	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			TGTAAACTTTGGGTAATCGAT	0.373000													85	152					0	0	1	0	0
BHLHB9	80823	broad.mit.edu	37	X	102004671	102004671	+	Missense_Mutation	SNP	G	G	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chrX:102004671G>T	ENST00000372735.1	+	4	1333	c.748G>T	c.(748-750)Gcc>Tcc	p.A250S	BHLHB9_ENST00000457056.1_Missense_Mutation_p.A250S|BHLHB9_ENST00000448867.1_Missense_Mutation_p.A250S|BHLHB9_ENST00000361229.4_Missense_Mutation_p.A250S|BHLHB9_ENST00000447531.1_Missense_Mutation_p.A250S			Q6PI77	BHLH9_HUMAN	basic helix-loop-helix domain containing, class B, 9	250						cytoplasm|nucleus	binding			cervix(1)|endometrium(6)|kidney(3)|large_intestine(1)|lung(8)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						TATTGTTCTGGCCTCCGCTGA	0.522000													60	7					4.6707e-30	5.43999e-30	1	1	0
RANBP6	26953	broad.mit.edu	37	9	6013624	6013624	+	Missense_Mutation	SNP	C	C	T	rs61758806	byFrequency	TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr9:6013624C>T	ENST00000259569.5	-	1	1994	c.1984G>A	c.(1984-1986)Gat>Aat	p.D662N	RANBP6_ENST00000485372.1_5'UTR	NM_001243202.1|NM_001243203.1|NM_012416.3	NP_001230131.1|NP_001230132.1|NP_036548.1	O60518	RNBP6_HUMAN	RAN binding protein 6	662					protein transport	cytoplasm|nucleus	binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(5)|large_intestine(8)|lung(9)|ovary(7)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		CAGCCATCATCGTCACTCATA	0.413000													5	70					0	0	1	0	0
TPTEP1	387590	broad.mit.edu	37	22	17117967	17117967	+	RNA	SNP	T	T	A			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr22:17117967T>A	ENST00000426585.1	+	0	267																											AATTATATCATCCTTTGCATT	0.348000													7	45					0	0	1	0	0
ADAT3	113179	broad.mit.edu	37	19	1912852	1912852	+	Missense_Mutation	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr19:1912852C>T	ENST00000329478.2	+	2	1026	c.806C>T	c.(805-807)cCg>cTg	p.P269L	SCAMP4_ENST00000409472.1_Intron|ADAT3_ENST00000602400.1_Missense_Mutation_p.P253L|SCAMP4_ENST00000316097.8_Intron|SCAMP4_ENST00000414057.2_Intron			Q96EY9	ADAT3_HUMAN	adenosine deaminase, tRNA-specific 3	253					tRNA processing		hydrolase activity|zinc ion binding			breast(1)|kidney(3)|pancreas(1)|skin(2)	7		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCTTCGCCCCGGCCGCTGCC	0.721000													9	12					0	0	1	0	0
SYNGR1	9145	broad.mit.edu	37	22	39777745	39777745	+	Silent	SNP	C	C	T			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr22:39777745C>T	ENST00000328933.5	+	4	543	c.528C>T	c.(526-528)gcC>gcT	p.A176A		NM_004711.4	NP_004702.2			synaptogyrin 1											endometrium(1)|kidney(1)|large_intestine(1)|lung(3)|skin(1)	7	Melanoma(58;0.04)					AGATTGGCGCCGACTCGGCCC	0.682000													35	41					0	0	1	0	0
CELF5	60680	broad.mit.edu	37	19	3281229	3281229	+	Silent	SNP	C	C	T	rs139670443	byFrequency	TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr19:3281229C>T	ENST00000541430.2	+	6	672	c.636C>T	c.(634-636)gcC>gcT	p.A212A	CELF5_ENST00000292672.2_Silent_p.A212A	NM_001172673.1	NP_001166144.1	Q8N6W0	CELF5_HUMAN	CUGBP, Elav-like family member 5	212	RRM 2.				mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			kidney(1)|large_intestine(2)|lung(7)|ovary(2)|skin(1)	13						TCAAGTTCGCCGACACGGACA	0.677000													18	98					0	0	1	0	0
SRGAP2-AS1	100873165	broad.mit.edu	37	1	121116648	121116648	+	RNA	DEL	A	A	-			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr1:121116648delA	ENST00000437515.1	-	0	329																											GCCCCCCTTTAAAAAAAAAGG	0.398													13	140	---	---	---	---					
SUCLG1	8802	broad.mit.edu	37	2	84658735	84658736	+	Frame_Shift_Del	DEL	TC	TC	-	rs145106503		TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr2:84658735_84658736delTC	ENST00000393868.2	-	7	931_932	c.721_722delGA	c.(721-723)afs	p.E241fs	SUCLG1_ENST00000491123.1_5'UTR	NM_003849.3	NP_003840.2	P53597	SUCA_HUMAN	succinate-CoA ligase, alpha subunit	241					tricarboxylic acid cycle		ATP citrate synthase activity|GTP binding|succinate-CoA ligase (GDP-forming) activity	p.E241K(1)		kidney(4)|large_intestine(4)|lung(2)	10					Succinic acid(DB00139)	CAAAAAGATTTCGAGGCAGTCA	0.361													35	121	---	---	---	---					
VIL1	7429	broad.mit.edu	37	2	219290373	219290379	+	Frame_Shift_Del	DEL	CCACTAC	CCACTAC	-			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr2:219290373_219290379delCCACTAC	ENST00000248444.5	+	4	274_280	c.186_192delCCACTAC	c.(184-192)atfs	p.IHY62fs	VIL1_ENST00000440053.1_Frame_Shift_Del_p.IHY62fs|VIL1_ENST00000392114.2_Intron	NM_007127.2	NP_009058.2	P09327	VILI_HUMAN	villin 1	62	Core.|Necessary for homodimerization.				actin filament capping|actin filament depolymerization|actin filament polymerization|actin filament severing|apoptosis|cellular response to epidermal growth factor stimulus|cytoplasmic actin-based contraction involved in cell motility|epidermal growth factor receptor signaling pathway|positive regulation of actin filament bundle assembly|positive regulation of epithelial cell migration|regulation of actin nucleation|regulation of cell shape|regulation of lamellipodium morphogenesis|regulation of wound healing|response to bacterium	actin filament bundle|cytoplasm|filopodium tip|intracellular membrane-bounded organelle|lamellipodium|microvillus|ruffle	actin filament binding|calcium ion binding|caspase inhibitor activity|lysophosphatidic acid binding|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Renal(207;0.0474)		Epithelial(149;6.88e-07)|all cancers(144;0.00013)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTATGACATCCACTACTGGATTGGCC	0.599													21	40	---	---	---	---					
MTIF3	219402	broad.mit.edu	37	13	28011285	28011288	+	Frame_Shift_Del	DEL	CTTT	CTTT	-			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr13:28011285_28011288delCTTT	ENST00000381116.1	-	6	817_820	c.583_586delAAAG	c.(583-588)gafs	p.KG195fs	MTIF3_ENST00000461838.1_5'UTR|MTIF3_ENST00000381120.3_Frame_Shift_Del_p.KG195fs|MTIF3_ENST00000405591.2_Frame_Shift_Del_p.KG195fs|MTIF3_ENST00000431572.2_Frame_Shift_Del_p.KG195fs			Q9H2K0	IF3M_HUMAN	mitochondrial translational initiation factor 3	195					regulation of translational initiation|ribosome disassembly	mitochondrion	ribosomal small subunit binding|translation initiation factor activity			endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	7		Lung SC(185;0.0161)	Colorectal(13;0.00042)|READ - Rectum adenocarcinoma(15;0.105)	all cancers(112;0.108)|OV - Ovarian serous cystadenocarcinoma(117;0.157)		ACATTTTTTCCTTTCTTTATGGTA	0.353													15	69	---	---	---	---					
B2M	567	broad.mit.edu	37	15	45003786	45003789	+	Frame_Shift_Del	DEL	TCTT	TCTT	-			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr15:45003786_45003789delTCTT	ENST00000558401.1	+	1	112_115	c.42_45delTCTT	c.(40-45)tcfs	p.SL14fs	B2M_ENST00000559916.1_Frame_Shift_Del_p.SL14fs|B2M_ENST00000544417.1_Frame_Shift_Del_p.SL14fs	NM_004048.2	NP_004039.1	P61769	B2MG_HUMAN	beta-2-microglobulin	14					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of defense response to virus by virus|viral reproduction	early endosome membrane|Golgi membrane|MHC class I protein complex	protein binding	p.L15fs*41(1)		breast(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(30)|kidney(8)|large_intestine(6)|lung(6)|ovary(2)|skin(2)|urinary_tract(1)	59		all_cancers(109;1.88e-13)|all_epithelial(112;2.13e-11)|Lung NSC(122;2.22e-07)|all_lung(180;1.81e-06)|Melanoma(134;0.0122)		all cancers(107;4.16e-21)|GBM - Glioblastoma multiforme(94;8.97e-07)|COAD - Colon adenocarcinoma(120;0.0357)|Colorectal(105;0.0377)|Lung(196;0.0903)|LUSC - Lung squamous cell carcinoma(244;0.192)		CGCTACTCTCTCTTTCTGGCCTGG	0.623													32	55	---	---	---	---					
LA16c-306E5.3	0	broad.mit.edu	37	16	3546141	3546141	+	RNA	DEL	A	A	-	rs74546027		TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr16:3546141delA	ENST00000574423.2	+	0	111																											actccgtctcaaaaaaaaaaa	0.557													3	4	---	---	---	---					
LOC101927978	101927978	broad.mit.edu	37	16	72763869	72763869	+	RNA	DEL	A	A	-			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr16:72763869delA	ENST00000563328.2	+	0	164																											GGTCCAAAACAAAAAAAAAAA	0.433													2	4	---	---	---	---					
SLC27A1	376497	broad.mit.edu	37	19	17597456	17597456	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr19:17597456delG	ENST00000252595.7	+	2	349	c.252delG	c.(250-252)gcfs	p.A84fs	SLC27A1_ENST00000442725.1_Frame_Shift_Del_p.A84fs|SLC27A1_ENST00000598424.1_5'UTR	NM_198580.1	NP_940982.1	Q6PCB7	S27A1_HUMAN	solute carrier family 27 (fatty acid transporter), member 1	84					cardiolipin biosynthetic process|fatty acid metabolic process|long-chain fatty acid transport|negative regulation of phospholipid biosynthetic process|phosphatidic acid biosynthetic process|phosphatidylcholine biosynthetic process|phosphatidylethanolamine biosynthetic process|phosphatidylinositol biosynthetic process|phosphatidylserine biosynthetic process|transmembrane transport	endomembrane system|integral to membrane	fatty acid transporter activity|nucleotide binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	23						TCTTTCAGGCGGTAGTGCAGC	0.697													12	9	---	---	---	---					
AC008984.2	0	broad.mit.edu	37	19	54843564	54843565	+	RNA	INS	-	-	C	rs144647366	by1000genomes	TCGA-ER-A42H-01A-11D-A24R-08	TCGA-ER-A42H-10A-01D-A24R-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4d688f07-6fb3-48f6-bcb3-348ae833a006	6e7c6102-f761-4eaf-bb7f-50f878f889d6	g.chr19:54843564_54843565insC	ENST00000507363.1	-	0	430																											CGGCTGCTCCTCCCCAGGCTGC	0.723													3	6	---	---	---	---					
