Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GRTP1	79774	broad.mit.edu	37	13	114009759	114009759	+	Silent	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr13:114009759G>A	ENST00000375430.4	-	3	265	c.219C>T	c.(217-219)caC>caT	p.H73H	GRTP1-AS1_ENST00000419199.1_RNA|GRTP1-AS1_ENST00000423246.1_RNA|GRTP1_ENST00000375431.4_Silent_p.H73H			Q5TC63	GRTP1_HUMAN	growth hormone regulated TBC protein 1	73	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	14	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			CGCGGGCACGGTGCTCCAGCG	0.667000													4	34					0	0	0.00024832	0	0
DCUN1D4	23142	broad.mit.edu	37	4	52779501	52779501	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr4:52779501C>A	ENST00000334635.5	+	10	946	c.766C>A	c.(766-768)Cta>Ata	p.L256I	DCUN1D4_ENST00000451288.2_Missense_Mutation_p.L300I|DCUN1D4_ENST00000381437.4_Missense_Mutation_p.L196I|DCUN1D4_ENST00000381441.3_Missense_Mutation_p.L221I	NM_001040402.1	NP_001035492.1	Q92564	DCNL4_HUMAN	DCN1, defective in cullin neddylation 1, domain containing 4	256	DCUN1.									endometrium(2)|large_intestine(2)|lung(2)|ovary(2)|skin(1)	9			GBM - Glioblastoma multiforme(4;1.93e-11)|LUSC - Lung squamous cell carcinoma(32;0.00654)			GTGCAATGTCCTAGAGTTTAG	0.368000													5	27					3.59834e-05	0.0022215	3.59834e-05	1	0
RGL3	57139	broad.mit.edu	37	19	11508131	11508131	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr19:11508131C>T	ENST00000380456.3	-	17	1952	c.1889G>A	c.(1888-1890)cGa>cAa	p.R630Q	RGL3_ENST00000568628.1_5'UTR|RGL3_ENST00000393423.3_Missense_Mutation_p.R636Q	NM_001035223.2|NM_001161616.1	NP_001030300.2|NP_001155088.1	Q3MIN7	RGL3_HUMAN	ral guanine nucleotide dissociation stimulator-like 3	630	Interaction with HRAS, MRAS and RIT1 (By similarity).|Ras-associating.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular				breast(1)|endometrium(4)|large_intestine(2)|lung(9)|ovary(1)|skin(1)	18						CAAGATGCTTCGATACAGGTT	0.677000													10	73					0	0	0.00010058	0	0
BAGE2	85319	broad.mit.edu	37	21	11058340	11058340	+	RNA	SNP	A	A	C	rs28617310	by1000genomes	TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr21:11058340A>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGGGTAAAGGAGAGAAATCTC	0.363000													5	102					0	0	1.23904e-05	0	0
DNAH5	1767	broad.mit.edu	37	5	13864596	13864596	+	Silent	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr5:13864596G>A	ENST00000265104.4	-	28	4610	c.4506C>T	c.(4504-4506)ctC>ctT	p.L1502L	CTB-51A17.1_ENST00000503244.1_RNA	NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1502	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TGTGCCCGGTGAGGGTGGTTA	0.458000									Kartagener syndrome				7	44					0	0	0.000157383	0	0
C12orf10	60314	broad.mit.edu	37	12	53696978	53696978	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr12:53696978G>A	ENST00000267103.5	+	3	541		c.e3+1		C12orf10_ENST00000548632.1_Splice_Site|C12orf10_ENST00000549488.1_Intron	NM_021640.3	NP_067653.3	Q86UA3	Q86UA3_HUMAN	chromosome 12 open reading frame 10											cervix(1)|endometrium(3)|kidney(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	20						CTATGACAAGGTGGGGACCTG	0.612000													5	25					0	0	3.59834e-05	0	0
PLCB1	23236	broad.mit.edu	37	20	8698351	8698351	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr20:8698351G>A	ENST00000378641.3	+	14	1844	c.1369G>A	c.(1369-1371)Gat>Aat	p.D457N	PLCB1_ENST00000494924.1_3'UTR|PLCB1_ENST00000378637.2_Missense_Mutation_p.D457N|PLCB1_ENST00000338037.6_Missense_Mutation_p.D457N	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	457	PI-PLC X-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						AAGCCCTATGGATTTAATGTA	0.403000													12	80					0	0	0.000308642	0	0
ANK3	288	broad.mit.edu	37	10	61836092	61836092	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr10:61836092G>A	ENST00000280772.1	-	37	4738	c.4547C>T	c.(4546-4548)cCa>cTa	p.P1516L	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000373827.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1516					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						TGACTTGGCTGGCCCAGGCAC	0.473000													6	25					0	0	8.12818e-05	0	0
CSMD2	114784	broad.mit.edu	37	1	34276407	34276407	+	Silent	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr1:34276407G>A	ENST00000373381.4	-	10	1559	c.1383C>T	c.(1381-1383)ttC>ttT	p.F461F	CSMD2_ENST00000338325.1_Silent_p.F18F	NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	421	CUB 3.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				ACTGAATGGGGAAATTGGGGG	0.547000													25	71					0	0	0.000147802	0	0
IL36A	27179	broad.mit.edu	37	2	113764230	113764230	+	Silent	SNP	G	G	A	rs148950825		TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr2:113764230G>A	ENST00000259211.6	+	3	591	c.180G>A	c.(178-180)ggG>ggA	p.G60G		NM_014440.1	NP_055255.1	Q9UHA7	IL36A_HUMAN	interleukin 36, alpha	60					immune response|inflammatory response	extracellular space	cytokine activity|interleukin-1 receptor binding	p.G60G(1)		large_intestine(1)|lung(3)|ovary(2)|skin(1)|stomach(2)	9						AAGACAGAGGGAACCCCATCT	0.522000													38	130					0	0	0.000191422	0	0
EIF4A1	1973	broad.mit.edu	37	17	7480012	7480012	+	Splice_Site	SNP	T	T	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr17:7480012T>A	ENST00000293831.8	+	5	530		c.e5+2		EIF4A1_ENST00000577269.1_Splice_Site|SENP3-EIF4A1_ENST00000579777.1_RNA|EIF4A1_ENST00000582746.1_Splice_Site	NM_001416.3	NP_001407.1	P60842	IF4A1_HUMAN	eukaryotic translation initiation factor 4A1						nuclear-transcribed mRNA poly(A) tail shortening	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA cap binding|translation initiation factor activity			NS(1)|breast(2)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	22						GATACCTGTGTGAGTAATTCG	0.522000													11	33					0	0	3.86212e-05	0	0
OR51M1	390059	broad.mit.edu	37	11	5410654	5410654	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr11:5410654C>T	ENST00000328611.3	+	1	48	c.26C>T	c.(25-27)cCt>cTt	p.P9L	AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380259.2_Intron|HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron	NM_001004756.2	NP_001004756.2	B2RNI9	B2RNI9_HUMAN	olfactory receptor, family 51, subfamily M, member 1	9						integral to membrane	olfactory receptor activity			NS(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|upper_aerodigestive_tract(1)	30		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;1.98e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TCGCTCAGTCCTCAATTCATG	0.403000													7	133					0	0	0.000157383	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107423245	107423245	+	Silent	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr2:107423245C>T	ENST00000409382.3	-	6	2089	c.1479G>A	c.(1477-1479)caG>caA	p.Q493Q	ST6GAL2_ENST00000361686.4_Silent_p.Q493Q	NM_001142351.1	NP_001135823.1	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 2	493					growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(8)|liver(1)|lung(30)|ovary(5)|pancreas(6)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	65						TGTTCAGGCGCTGCACCAGGA	0.622000													9	65					0	0	6.40141e-05	0	0
KCNH5	27133	broad.mit.edu	37	14	63174914	63174914	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr14:63174914G>A	ENST00000322893.7	-	11	2547	c.2279C>T	c.(2278-2280)cCc>cTc	p.P760L	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	760					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		CGTCTGAATGGGAGTAATCTG	0.532000													5	37					0	0	1.23904e-05	0	0
ERC2	26059	broad.mit.edu	37	3	56207504	56207504	+	Silent	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr3:56207504C>T	ENST00000288221.6	-	4	1374	c.1119G>A	c.(1117-1119)acG>acA	p.T373T		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	373						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GGAGAGCCTTCGTCTTGGCTG	0.488000													6	38					0	0	8.12818e-05	0	0
FLG	2312	broad.mit.edu	37	1	152280145	152280145	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr1:152280145C>T	ENST00000368799.1	-	3	7252	c.7217G>A	c.(7216-7218)gGa>gAa	p.G2406E	FLG-AS1_ENST00000420707.1_RNA|FLG-AS1_ENST00000593011.1_RNA	NM_002016.1	NP_002007.1	P20930	FILA_HUMAN	filaggrin	2406	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			autonomic_ganglia(1)|breast(13)|central_nervous_system(5)|cervix(2)|endometrium(38)|haematopoietic_and_lymphoid_tissue(1)|kidney(16)|large_intestine(57)|lung(211)|ovary(13)|pancreas(1)|prostate(15)|skin(24)|stomach(5)|upper_aerodigestive_tract(10)|urinary_tract(12)	424	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCAGACCTTCCTGCTGACCG	0.592000									Ichthyosis				12	103					0	0	9.7654e-05	0	0
C1orf116	79098	broad.mit.edu	37	1	207195689	207195689	+	Silent	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr1:207195689G>A	ENST00000359470.5	-	4	1669	c.1420C>T	c.(1420-1422)Ctg>Ttg	p.L474L	C1orf116_ENST00000461135.2_Silent_p.L228L	NM_023938.5	NP_076427.2	Q9BW04	SARG_HUMAN	chromosome 1 open reading frame 116	474						cytoplasm|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(4)|stomach(1)	29	Prostate(682;0.19)					ATCTGTCTCAGGCCAGGGGTG	0.557000													5	32					0	0	3.59834e-05	0	0
PI15	51050	broad.mit.edu	37	8	75756325	75756325	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr8:75756325G>A	ENST00000260113.2	+	3	562	c.383G>A	c.(382-384)cGc>cAc	p.R128H	RP11-758M4.4_ENST00000523860.1_RNA|RP11-758M4.4_ENST00000518128.1_RNA|PI15_ENST00000523773.1_Missense_Mutation_p.R128H	NM_015886.3	NP_056970.1	O43692	PI15_HUMAN	peptidase inhibitor 15	128						extracellular region	peptidase inhibitor activity	p.R128H(1)		breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|pancreas(1)|skin(1)	30	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			CTATCTGTACGCACTGGAAGG	0.408000													18	113					0	0	9.7654e-05	0	0
PCSK5	5125	broad.mit.edu	37	9	78925636	78925636	+	Silent	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr9:78925636G>A	ENST00000545128.1	+	29	4210	c.3672G>A	c.(3670-3672)agG>agA	p.R1224R		NM_001190482.1	NP_001177411.1	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	870					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						CTTCCGTAAGGAGTGGGAGCT	0.557000													4	15					0	0	0.00024832	0	0
MAP1A	4130	broad.mit.edu	37	15	43817052	43817052	+	Silent	SNP	A	A	G			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr15:43817052A>G	ENST00000382031.1	+	5	4126	c.4095A>G	c.(4093-4095)caA>caG	p.Q1365Q	MAP1A_ENST00000399453.1_Silent_p.Q1127Q|MAP1A_ENST00000300231.5_Silent_p.Q1127Q			P78559	MAP1A_HUMAN	microtubule-associated protein 1A	1127						cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|liver(2)|lung(19)|ovary(5)|pancreas(3)|prostate(2)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	66		all_cancers(109;1.03e-14)|all_epithelial(112;2.23e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.05e-06)	Estramustine(DB01196)	CTTTACCCCAAGAACCTGGCA	0.532000													16	38					0	0	0.000422831	0	0
PDIA2	64714	broad.mit.edu	37	16	336416	336416	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr16:336416G>A	ENST00000219406.6	+	8	1201	c.1183G>A	c.(1183-1185)Ggc>Agc	p.G395S	PDIA2_ENST00000404312.1_Missense_Mutation_p.G392S	NM_006849.2	NP_006840.2	Q13087	PDIA2_HUMAN	protein disulfide isomerase family A, member 2	395	Thioredoxin 2.				apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			breast(1)|central_nervous_system(4)|kidney(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	17		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				GACCCTCGTGGGCAAGAATTT	0.577000													5	36					0	0	1.23904e-05	0	0
EMR3	84658	broad.mit.edu	37	19	14748943	14748943	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr19:14748943C>T	ENST00000253673.5	-	11	1558	c.1458G>A	c.(1456-1458)tgG>tgA	p.W486*	EMR3_ENST00000443157.2_Nonsense_Mutation_p.W360*|EMR3_ENST00000599900.1_Nonsense_Mutation_p.W271*|EMR3_ENST00000344373.4_Nonsense_Mutation_p.W434*	NM_032571.3	NP_115960.2	Q9BY15	EMR3_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 3	486					neuropeptide signaling pathway	extracellular space|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(1)|autonomic_ganglia(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(12)|lung(14)|ovary(7)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	50						AAAGGTGAGGCCAGGAGGCTG	0.498000													14	78					0	0	0.000308642	0	0
EP400	57634	broad.mit.edu	37	12	132547087	132547087	+	Silent	SNP	G	G	A	rs12366766		TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr12:132547087G>A	ENST00000333577.4	+	48	8392	c.8283G>A	c.(8281-8283)caG>caA	p.Q2761Q	EP400_ENST00000389561.2_Silent_p.Q2725Q|EP400_ENST00000332482.4_Silent_p.Q2688Q|EP400_ENST00000389562.2_Silent_p.Q2724Q|EP400_ENST00000330386.6_Silent_p.Q2644Q			Q96L91	EP400_HUMAN	E1A binding protein p400	2761	Interaction with ZNF42 (By similarity).|Poly-Gln.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.Q2724Q(16)|p.Q2725Q(1)		NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcagcagcaacaacagc	0.562000													6	38					0	0	0.000274275	0	0
KRT5	3852	broad.mit.edu	37	12	52914008	52914008	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr12:52914008G>A	ENST00000252242.4	-	1	463	c.73C>T	c.(73-75)Ccg>Tcg	p.P25S		NM_000424.3	NP_000415.2	P13647	K2C5_HUMAN	keratin 5	25	Head.		P -> L (in MP-EBS; dbSNP:rs57499817).		epidermis development|hemidesmosome assembly	cytosol|keratin filament	protein binding|structural constituent of cytoskeleton			endometrium(5)|kidney(1)|large_intestine(8)|lung(15)|prostate(4)|skin(2)	35				BRCA - Breast invasive adenocarcinoma(357;0.189)		GAGACAGACGGGGTGATGGCA	0.657000													5	16					0	0	1.23904e-05	0	0
DNM1P47	100216544	broad.mit.edu	37	15	102292953	102292953	+	RNA	SNP	T	T	C			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr15:102292953T>C	ENST00000561463.1	+	0	999																											GGCACAGCGGTGCGACGAGAT	0.587000													2	0					0	0	6.4e-05	0	0
NEK5	341676	broad.mit.edu	37	13	52639739	52639739	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr13:52639739G>A	ENST00000355568.4	-	22	2070	c.1931C>T	c.(1930-1932)tCc>tTc	p.S644F		NM_199289.1	NP_954983.1	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	644							ATP binding|metal ion binding|protein serine/threonine kinase activity			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(2)|large_intestine(8)|lung(11)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	39		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		AGTCTGCGTGGAAAACCCTGG	0.502000													9	36					0	0	0.000442599	0	0
AMPD1	270	broad.mit.edu	37	1	115221134	115221134	+	Silent	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr1:115221134G>A	ENST00000369538.3	-	7	1046	c.999C>T	c.(997-999)atC>atT	p.I333I	AMPD1_ENST00000353928.6_Silent_p.I304I|AMPD1_ENST00000520113.2_Silent_p.I337I	NM_001172626.1	NP_001166097.1	P23109	AMPD1_HUMAN	adenosine monophosphate deaminase 1	304					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			NS(1)|breast(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(17)|ovary(3)|pancreas(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	45	all_epithelial(7;7.83e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)	Adenosine monophosphate(DB00131)	CGGCTGCATGGATATGGGTGT	0.398000													6	30					0	0	0.000442599	0	0
SBNO1	55206	broad.mit.edu	37	12	123782672	123782672	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr12:123782672C>T	ENST00000420886.2	-	30	3891	c.3892G>A	c.(3892-3894)Ggt>Agt	p.G1298S	SBNO1_ENST00000602398.1_Missense_Mutation_p.G1298S|SBNO1_ENST00000602750.1_Missense_Mutation_p.G1297S|SBNO1_ENST00000267176.4_Missense_Mutation_p.G1297S	NM_001167856.1	NP_001161328.1	A3KN83	SBNO1_HUMAN	strawberry notch homolog 1 (Drosophila)	1298							ATP binding|DNA binding|hydrolase activity			NS(2)|breast(6)|cervix(2)|endometrium(8)|kidney(3)|large_intestine(11)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(2)	62	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		CAACGAAGACCTATTTCACAA	0.418000													10	50					0	0	3.86212e-05	0	0
NLRP9	338321	broad.mit.edu	37	19	56243679	56243679	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr19:56243679C>A	ENST00000332836.2	-	2	1545	c.1518G>T	c.(1516-1518)atG>atT	p.M506I		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	506						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		AGGTCTCCAGCATGCTGACGA	0.443000													17	78					6.94344e-10	4.36321e-08	7.07596e-05	1	0
C1orf116	79098	broad.mit.edu	37	1	207195703	207195703	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr1:207195703C>T	ENST00000359470.5	-	4	1655	c.1406G>A	c.(1405-1407)aGc>aAc	p.S469N	C1orf116_ENST00000461135.2_Missense_Mutation_p.S223N	NM_023938.5	NP_076427.2	Q9BW04	SARG_HUMAN	chromosome 1 open reading frame 116	469						cytoplasm|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|prostate(2)|skin(4)|stomach(1)	29	Prostate(682;0.19)					AGGGGTGTTGCTCTCCTGGAG	0.552000													4	33					0	0	3.59834e-05	0	0
CASS4	57091	broad.mit.edu	37	20	55012445	55012445	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr20:55012445G>A	ENST00000371336.3	+	2	463	c.262G>A	c.(262-264)Gaa>Aaa	p.E88K	CASS4_ENST00000360314.3_Missense_Mutation_p.E88K|CASS4_ENST00000434344.1_Missense_Mutation_p.E88K	NM_001164114.1|NM_020356.3	NP_001157586.1|NP_065089.2	Q9NQ75	CASS4_HUMAN	Cas scaffolding protein family member 4	88					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(4)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	54						GAGAGGCCTGGAAGAAGCTCC	0.637000													8	22					0	0	0.000157383	0	0
CHD8	57680	broad.mit.edu	37	14	21870235	21870235	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr14:21870235T>A	ENST00000399982.2	-	19	4007	c.3943A>T	c.(3943-3945)Atc>Ttc	p.I1315F	CHD8_ENST00000557364.1_Missense_Mutation_p.I1315F|CHD8_ENST00000555962.1_5'UTR|CHD8_ENST00000430710.3_Missense_Mutation_p.I1036F	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1315					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TCCTCCATGATGGCTGCATAT	0.378000													7	54					0	0	8.12818e-05	0	0
UBE2F	140739	broad.mit.edu	37	2	238940897	238940897	+	Splice_Site	SNP	T	T	C			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr2:238940897T>C	ENST00000272930.4	+	8	638		c.e8+2		UBE2F_ENST00000409633.1_Splice_Site|UBE2F_ENST00000409953.1_Splice_Site|UBE2F_ENST00000409332.1_Splice_Site|UBE2F_ENST00000414443.1_Splice_Site|UBE2F-SCLY_ENST00000449191.1_Intron	NM_001278305.1|NM_080678.2	NP_001265234.1|NP_542409.1	Q969M7	UBE2F_HUMAN	ubiquitin-conjugating enzyme E2F (putative)						protein neddylation		ATP binding|NEDD8 ligase activity|protein binding			endometrium(1)|large_intestine(1)	2		Breast(86;0.0042)|Renal(207;0.00571)|Ovarian(221;0.17)|all_hematologic(139;0.182)		Epithelial(121;6.7e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|Kidney(56;3.53e-09)|KIRC - Kidney renal clear cell carcinoma(57;9.79e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000136)|Lung(119;0.0126)|LUSC - Lung squamous cell carcinoma(224;0.0301)		TTGTTTACTGTAAGTACAGTG	0.328000													4	19					0	0	3.59834e-05	0	0
CLASRP	11129	broad.mit.edu	37	19	45570681	45570681	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr19:45570681C>T	ENST00000544944.2	+	13	2188	c.1496C>T	c.(1495-1497)tCc>tTc	p.S499F	CLASRP_ENST00000221455.3_Missense_Mutation_p.S499F|CLASRP_ENST00000391953.4_Missense_Mutation_p.S437F			Q8N2M8	CLASR_HUMAN	CLK4-associating serine/arginine rich protein	499	Arg-rich.|Ser-rich.				mRNA processing|RNA splicing	nucleus				breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|pancreas(2)|prostate(1)	16						AGCAGCTGGTCCCTCAGCCCG	0.746000													10	40					0	0	3.86212e-05	0	0
RBM6	10180	broad.mit.edu	37	3	50005048	50005048	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr3:50005048C>T	ENST00000266022.4	+	3	449	c.190C>T	c.(190-192)Cct>Tct	p.P64S	RBM6_ENST00000539992.1_Intron|RBM6_ENST00000443081.1_5'UTR|RBM6_ENST00000442092.1_Intron|RBM6_ENST00000441115.1_Intron|RBM6_ENST00000422955.1_Intron	NM_005777.2	NP_005768.1	P78332	RBM6_HUMAN	RNA binding motif protein 6	64					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(10)|ovary(3)|prostate(1)|skin(4)|urinary_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		TTCGGGGCCTCCTTTTGCAAA	0.527000													6	81					0	0	8.12818e-05	0	0
TMEM260	54916	broad.mit.edu	37	14	57075882	57075882	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr14:57075882C>T	ENST00000261556.6	+	6	817	c.695C>T	c.(694-696)cCc>cTc	p.P232L	TMEM260_ENST00000538838.1_Missense_Mutation_p.P232L|TMEM260_ENST00000536419.1_5'UTR	NM_017799.3	NP_060269.3			transmembrane protein 260																		GGTTTGCTGCCCTATGTCCAC	0.473000													16	302					0	0	0.000422831	0	0
MBD5	55777	broad.mit.edu	37	2	149248079	149248079	+	Silent	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr2:149248079C>T	ENST00000407073.1	+	12	5176	c.4179C>T	c.(4177-4179)atC>atT	p.I1393I	MBD5_ENST00000404807.1_Silent_p.I1626I	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	1393	PWWP.					chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		GGGGCCAAATCAAAGGACTGA	0.448000													14	66					0	0	0.000219431	0	0
MAGEC3	139081	broad.mit.edu	37	X	140984915	140984915	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chrX:140984915T>G	ENST00000298296.1	+	7	1371	c.1371T>G	c.(1369-1371)gaT>gaG	p.D457E	MAGEC3_ENST00000409007.1_Missense_Mutation_p.D159E|MAGEC3_ENST00000443323.2_Missense_Mutation_p.D79E|MAGEC3_ENST00000483584.1_3'UTR|MAGEC3_ENST00000544766.1_Missense_Mutation_p.D159E|MAGEC3_ENST00000536088.1_Missense_Mutation_p.D159E	NM_138702.1	NP_619647.1	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3	457	MAGE 2.									NS(2)|breast(3)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|liver(1)|lung(32)|ovary(1)|prostate(1)|skin(5)|stomach(1)|urinary_tract(2)	69	Acute lymphoblastic leukemia(192;6.56e-05)					ATGCCCTGGATGAAAAGGTGG	0.483000													8	26					0	0	0.000274275	0	0
SORL1	6653	broad.mit.edu	37	11	121430338	121430338	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr11:121430338G>A	ENST00000260197.7	+	21	3150	c.3021G>A	c.(3019-3021)atG>atA	p.M1007I		NM_003105.5	NP_003096.1	Q92673	SORL_HUMAN	sortilin-related receptor, L(DLR class) A repeats containing	1007					cholesterol metabolic process|lipid transport|receptor-mediated endocytosis	integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|transmembrane receptor activity			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(2)|lung(34)|ovary(5)|pancreas(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(2)	91		Breast(109;0.00119)|Medulloblastoma(222;0.0429)|all_neural(223;0.113)		BRCA - Breast invasive adenocarcinoma(274;3.34e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.108)		TCATGGACATGAAGATTTTCT	0.498000													7	63					0	0	0.000157383	0	0
RSPO1	284654	broad.mit.edu	37	1	38082349	38082349	+	Splice_Site	SNP	T	T	C			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr1:38082349T>C	ENST00000356545.2	-	5	882		c.e5-2		RSPO1_ENST00000401068.1_Splice_Site|RSPO1_ENST00000401069.1_Splice_Site|RSPO1_ENST00000401071.2_Splice_Site|RSPO1_ENST00000401070.1_Splice_Site|RSPO1_ENST00000373059.1_Splice_Site	NM_001038633.3	NP_001033722.1	Q2MKA7	RSPO1_HUMAN	R-spondin 1						positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CGGCACTGACTGCAAAGGTGG	0.557000													4	62					0	0	0.00024832	0	0
TTC31	64427	broad.mit.edu	37	2	74719860	74719860	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr2:74719860C>T	ENST00000233623.5	+	12	1256	c.1249C>T	c.(1249-1251)Ctc>Ttc	p.L417F	TTC31_ENST00000442235.2_Intron|TTC31_ENST00000410003.1_3'UTR	NM_022492.4	NP_071937.4	Q49AM3	TTC31_HUMAN	tetratricopeptide repeat domain 31	417							binding			breast(1)|endometrium(1)|large_intestine(4)|lung(2)|skin(1)	9						CTCTTGCCTTCTCCACCTCAC	0.592000													10	34					0	0	6.40141e-05	0	0
OSMR	9180	broad.mit.edu	37	5	38881844	38881844	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr5:38881844G>A	ENST00000274276.3	+	4	798	c.396G>A	c.(394-396)tgG>tgA	p.W132*	OSMR_ENST00000502536.1_Nonsense_Mutation_p.W132*	NM_003999.2	NP_003990.1	Q99650	OSMR_HUMAN	oncostatin M receptor	132					cell proliferation|positive regulation of cell proliferation	oncostatin-M receptor complex	growth factor binding|oncostatin-M receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	46	all_lung(31;0.000365)					GGAGCAACTGGAGTTCCTGGG	0.423000													12	74					0	0	0.000422831	0	0
DENND6A	201627	broad.mit.edu	37	3	57651848	57651848	+	Splice_Site	SNP	A	A	G			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr3:57651848A>G	ENST00000311128.5	-	4	503		c.e4+1			NM_152678.2	NP_689891.1			DENN/MADD domain containing 6A																		TACTTTTCCAACCTTTAAGTA	0.378000													9	54					0	0	0.000274275	0	0
AFAP1L1	134265	broad.mit.edu	37	5	148695801	148695801	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr5:148695801C>T	ENST00000296721.4	+	11	1300	c.1202C>T	c.(1201-1203)tCc>tTc	p.S401F	AFAP1L1_ENST00000515000.1_Missense_Mutation_p.S401F	NM_001146337.1|NM_152406.2	NP_001139809.1|NP_689619.1	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	401							protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(10)|ovary(1)|pancreas(1)|skin(2)	26			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTGGCTTCTCCAAGAAGAAG	0.602000													9	71					0	0	0.000274275	0	0
KLHL40	131377	broad.mit.edu	37	3	42728022	42728022	+	Silent	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr3:42728022G>A	ENST00000287777.4	+	1	1012	c.912G>A	c.(910-912)ggG>ggA	p.G304G		NM_152393.2	NP_689606.2			kelch-like family member 40																		TCCTTCCTGGGATCCTCAATG	0.567000													15	69					0	0	0.000308642	0	0
DNAH7	56171	broad.mit.edu	37	2	196851910	196851910	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr2:196851910C>T	ENST00000312428.6	-	14	1734	c.1634G>A	c.(1633-1635)cGt>cAt	p.R545H		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	545	Stem (By similarity).		R -> C (in dbSNP:rs10931715).		ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						CATTCCTAAACGAATAGTCTG	0.294000													8	35					0	0	0.000274275	0	0
POTEE	445582	broad.mit.edu	37	2	132021757	132021757	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr2:132021757G>A	ENST00000356920.5	+	15	2823	c.2729G>A	c.(2728-2730)cGt>cAt	p.R910H	POTEE_ENST00000358087.5_3'UTR|PLEKHB2_ENST00000404460.1_Intron|PLEKHB2_ENST00000303908.3_Intron	NM_001083538.1	NP_001077007.1	Q6S8J3	POTEE_HUMAN	POTE ankyrin domain family, member E	910	Actin-like.						ATP binding										GAAATCGTGCGTGACATCAAA	0.602000													9	146					0	0	0.000151284	0	0
LRP1B	53353	broad.mit.edu	37	2	141773459	141773459	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr2:141773459C>T	ENST00000389484.3	-	13	2967	c.1996G>A	c.(1996-1998)Gaa>Aaa	p.E666K		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	666					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATTTCATCTTCCTCCCAGTCT	0.413000										TSP Lung(27;0.18)			12	60					0	0	0.000151284	0	0
FOXF2	2295	broad.mit.edu	37	6	1394974	1394974	+	Silent	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr6:1394974C>T	ENST00000259806.1	+	2	1329	c.1215C>T	c.(1213-1215)gaC>gaT	p.D405D		NM_001452.1	NP_001443.1	Q12947	FOXF2_HUMAN	forkhead box F2	405					epithelial to mesenchymal transition|genitalia development|palate development|pattern specification process|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription factor binding			large_intestine(2)|lung(5)|prostate(1)	8	Ovarian(93;0.0733)	all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.095)		CAGTGTGTGACAGAAAAGATT	0.458000													8	82					0	0	0.000442599	0	0
KBTBD6	89890	broad.mit.edu	37	13	41706580	41706580	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr13:41706580T>C	ENST00000379485.1	-	1	302	c.68A>G	c.(67-69)aAg>aGg	p.K23R	KBTBD6_ENST00000499385.2_Missense_Mutation_p.K23R	NM_152903.4	NP_690867.3	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain containing 6	23							protein binding			NS(1)|breast(1)|endometrium(8)|kidney(4)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|skin(4)|urinary_tract(4)	43		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		GTGAATCTTCTTGGGCCGCTT	0.617000													27	109					0	0	0.000147802	0	0
ARAP1	116985	broad.mit.edu	37	11	72423666	72423666	+	Translation_Start_Site	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr11:72423666C>T	ENST00000393605.3	-	0	530				ARAP1_ENST00000455638.2_Intron|ARAP1_ENST00000426523.1_Intron|ARAP1_ENST00000393609.3_Intron|ARAP1_ENST00000334211.8_Intron|ARAP1_ENST00000429686.1_Intron|ARAP1_ENST00000359373.5_Intron			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1						actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						ACAGATCACACCCACCCGGGG	0.677000													19	89					0	0	9.7654e-05	0	0
SDPR	8436	broad.mit.edu	37	2	192701266	192701266	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr2:192701266C>T	ENST00000304141.4	-	2	990	c.661G>A	c.(661-663)Gaa>Aaa	p.E221K		NM_004657.5	NP_004648.1	O95810	SDPR_HUMAN	serum deprivation response	221						caveola|cytosol	phosphatidylserine binding|protein binding			NS(1)|central_nervous_system(1)|cervix(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|urinary_tract(3)	23			OV - Ovarian serous cystadenocarcinoma(117;0.0647)		Phosphatidylserine(DB00144)	TCCACCTTTTCCTCGGCACTG	0.483000													14	89					0	0	0.000151284	0	0
LPAR4	2846	broad.mit.edu	37	X	78010399	78010399	+	Silent	SNP	C	C	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chrX:78010399C>T	ENST00000435339.2	+	2	438	c.33C>T	c.(31-33)ttC>ttT	p.F11F	RP11-475D8.1_ENST00000514744.1_RNA|LPAR4_ENST00000373301.2_Silent_p.F11F	NM_005296.2	NP_005287.1	Q99677	LPAR4_HUMAN	lysophosphatidic acid receptor 4	11						integral to plasma membrane	lipid binding|purinergic nucleotide receptor activity, G-protein coupled			breast(3)|endometrium(3)|kidney(4)|large_intestine(4)|lung(16)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)	38						ACTTCCAATTCCAAGATTCAA	0.453000													15	27					0	0	0.000308642	0	0
PRDX1	5052	broad.mit.edu	37	1	45977053	45977054	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr1:45977053_45977054insT	ENST00000262746.1	-	6	886_887	c.547_548insA	c.(547-549)catfs	p.H183fs	PRDX1_ENST00000372079.1_Frame_Shift_Ins_p.H81fs|PRDX1_ENST00000319248.8_Frame_Shift_Ins_p.H183fs	NM_002574.3|NM_181696.2	NP_002565.1|NP_859047.1	Q06830	PRDX1_HUMAN	peroxiredoxin 1	183					cell proliferation|cell redox homeostasis|hydrogen peroxide catabolic process|skeletal system development	melanosome|mitochondrion|nucleus	protein binding|thioredoxin peroxidase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|skin(1)	12	Acute lymphoblastic leukemia(166;0.155)					AGGCTTGATGGTATCACTGCCA	0.495													32	196	---	---	---	---					
H3F3AP4	440926	broad.mit.edu	37	2	175585079	175585079	+	RNA	DEL	A	A	-			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr2:175585079delA	ENST00000442996.1	+	0	217																											TTTCATTCTCAAAAAAAAAAA	0.368											OREG0015078	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	2	4	---	---	---	---					
PABPC1	26986	broad.mit.edu	37	8	101721933	101721933	+	Frame_Shift_Del	DEL	T	T	-	rs112966887		TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr8:101721933delT	ENST00000318607.5	-	8	2127	c.999delA	c.(997-999)aafs	p.K333fs	PABPC1_ENST00000519596.1_5'UTR|PABPC1_ENST00000519004.1_Frame_Shift_Del_p.K288fs|PABPC1_ENST00000522387.1_Frame_Shift_Del_p.K301fs	NM_002568.3	NP_002559.2	P11940	PABP1_HUMAN	poly(A) binding protein, cytoplasmic 1	333	RRM 4.				mRNA polyadenylation|mRNA stabilization|negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|translation	catalytic step 2 spliceosome|cytosol	nucleotide binding|poly(A) RNA binding|protein C-terminus binding|translation activator activity			breast(2)|endometrium(4)|kidney(15)|large_intestine(4)|lung(13)|prostate(1)|skin(1)	40	all_cancers(14;6.8e-05)|all_epithelial(15;3.16e-07)|Lung NSC(17;0.000453)|all_lung(17;0.00125)		Epithelial(11;6.37e-11)|all cancers(13;1.11e-08)|OV - Ovarian serous cystadenocarcinoma(57;3.91e-05)|STAD - Stomach adenocarcinoma(118;0.206)			AACCAAACCCTTTGCTGCGAC	0.383													9	74	---	---	---	---					
SMC2	10592	broad.mit.edu	37	9	106862421	106862422	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr9:106862421_106862422insA	ENST00000286398.7	+	6	816_817	c.528_529insA	c.(526-531)taaaaafs	p.*K176fs	SMC2_ENST00000374787.3_Frame_Shift_Ins_p.*K176fs|SMC2_ENST00000374793.3_Frame_Shift_Ins_p.*K176fs|SMC2_ENST00000303219.8_Frame_Shift_Ins_p.*K176fs	NM_001042551.1|NM_001265602.1|NM_006444.2	NP_001036016.1|NP_001252531.1|NP_006435.2	O95347	SMC2_HUMAN	structural maintenance of chromosomes 2	176					cell division|mitotic chromosome condensation|symbiosis, encompassing mutualism through parasitism	condensin complex|cytoplasm|nuclear chromosome	ATP binding|protein heterodimerization activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(14)|ovary(5)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)	48						TGTATGAATACAAAAAAATAGC	0.317													9	87	---	---	---	---					
DGKZ	8525	broad.mit.edu	37	11	46387931	46387933	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr11:46387931_46387933delCCT	ENST00000454345.1	+	2	250_252	c.125_127delCCT	c.(124-129)gcc>g	p.AS42del	DGKZ_ENST00000532868.2_Intron|DGKZ_ENST00000543978.1_Intron|DGKZ_ENST00000525434.1_3'UTR|DGKZ_ENST00000528615.1_Intron|DGKZ_ENST00000527911.1_Intron|DGKZ_ENST00000343674.6_Intron|DGKZ_ENST00000318201.8_Intron|DGKZ_ENST00000456247.2_Intron|DGKZ_ENST00000421244.2_Intron|DGKZ_ENST00000395574.3_Intron	NM_001105540.1	NP_001099010.1	Q13574	DGKZ_HUMAN	diacylglycerol kinase, zeta	42					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		GCTGGGCAGGCCTCCTCCTCACT	0.759													3	4	---	---	---	---					
SLC9A7P1	121456	broad.mit.edu	37	12	98850722	98850722	+	RNA	DEL	C	C	-			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr12:98850722delC	ENST00000554295.1	-	0	201					NR_033801.1																						TTCTCAGTGACGAGCTCCTCC	0.647													2	4	---	---	---	---					
TP53	7157	broad.mit.edu	37	17	7579399	7579399	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr17:7579399delA	ENST00000420246.2	-	4	420	c.288delT	c.(286-288)tcfs	p.S96fs	TP53_ENST00000359597.4_Frame_Shift_Del_p.S96fs|TP53_ENST00000269305.4_Frame_Shift_Del_p.S96fs|TP53_ENST00000455263.2_Frame_Shift_Del_p.S96fs|TP53_ENST00000413465.2_Frame_Shift_Del_p.S96fs|TP53_ENST00000445888.2_Frame_Shift_Del_p.S96fs	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	96	Interaction with WWOX.		S -> C (in a sporadic cancer; somatic mutation).|S -> F (in sporadic cancers; somatic mutation).|S -> P (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(8)|p.G59fs*23(3)|p.V73fs*9(1)|p.W91fs*13(1)|p.P13fs*18(1)|p.S33fs*23(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGAAGGGACAGAAGATGACA	0.637		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			7	41	---	---	---	---					
POLDIP2	26073	broad.mit.edu	37	17	26684390	26684391	+	Frame_Shift_Ins	INS	-	-	C	rs148075904	by1000genomes	TCGA-FS-A1Z4-06A-11D-A197-08	TCGA-FS-A1Z4-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b80a0277-7426-44ec-871f-363e9db7af50	ea52816d-f4fd-4a43-b004-20dc0f4cb59d	g.chr17:26684390_26684391insC	ENST00000540200.1	-	2	80_81	c.81_82insG	c.(79-84)aacgctfs	p.NA27fs	POLDIP2_ENST00000003607.4_5'UTR	NM_015584.3	NP_056399.1	Q9Y2S7	PDIP2_HUMAN	polymerase (DNA-directed), delta interacting protein 2	28						mitochondrial nucleoid|nucleus						all_lung(13;0.000354)|Lung NSC(42;0.00115)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		GCACAGAGCGGCTTTGCCACCG	0.762													9	8	---	---	---	---					
