Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MUC16	94025	broad.mit.edu	37	19	9083324	9083324	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9083324C>T	ENST00000397910.4	-	1	8694	c.8491G>A	c.(8491-8493)Gaa>Aaa	p.E2831K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	2831	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGGTGATTTCAGACATGGCT	0.507000													8	8					0	0	0.006214	0	0
TMEM117	84216	broad.mit.edu	37	12	44238710	44238710	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:44238710C>T	ENST00000536799.1	+	1	44	c.44C>T	c.(43-45)tCt>tTt	p.S15F	TMEM117_ENST00000266534.3_Silent_p.L86L|TMEM117_ENST00000551577.1_Silent_p.L86L			Q9H0C3	TM117_HUMAN	transmembrane protein 117	0						endoplasmic reticulum|integral to membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|urinary_tract(1)	23	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		TGGCAAATTTCTGTTCCATCA	0.358000													30	63					0	0	0.002836	0	0
IL1R1	3554	broad.mit.edu	37	2	102793021	102793021	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:102793021A>T	ENST00000410023.1	+	12	1830	c.1512A>T	c.(1510-1512)aaA>aaT	p.K504N	IL1R1_ENST00000424272.1_3'UTR|IL1R1_ENST00000409589.1_Intron|IL1R1_ENST00000409929.1_Missense_Mutation_p.K473N|AC007271.3_ENST00000428188.1_RNA|IL1R1_ENST00000233946.3_Missense_Mutation_p.K504N			P14778	IL1R1_HUMAN	interleukin 1 receptor, type I	504	TIR.				innate immune response	integral to plasma membrane	interleukin-1, Type I, activating receptor activity|platelet-derived growth factor receptor binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(4)|prostate(2)|skin(3)	19					Anakinra(DB00026)	AATCGATTAAATTCATTAAGC	0.428000													11	11					0	0	0.001368	0	0
GLT6D1	360203	broad.mit.edu	37	9	138516324	138516324	+	Silent	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:138516324A>G	ENST00000371763.1	-	5	703	c.450T>C	c.(448-450)caT>caC	p.H150H		NM_182974.2	NP_892019.2	Q7Z4J2	GL6D1_HUMAN	glycosyltransferase 6 domain containing 1	150					carbohydrate metabolic process	integral to membrane	transferase activity, transferring hexosyl groups			endometrium(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	15		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;4.3e-07)|Epithelial(140;1.58e-06)|all cancers(34;5.36e-05)		GGCTCTTCACATGCACCAGGG	0.562000													4	18					0	0	0.000248	0	0
ZFP3	124961	broad.mit.edu	37	17	4995744	4995744	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:4995744G>A	ENST00000318833.3	+	2	1281	c.945G>A	c.(943-945)ggG>ggA	p.G315G		NM_153018.2	NP_694563.1	Q96NJ6	ZFP3_HUMAN	ZFP3 zinc finger protein	315					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(3)|prostate(1)	20						ATGAATGTGGGAAGGGCTTCG	0.433000													9	10					0	0	0.006214	0	0
DNASE1L3	1776	broad.mit.edu	37	3	58190532	58190532	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:58190532C>T	ENST00000483681.1	-	6	978	c.397G>A	c.(397-399)Gag>Aag	p.E133K	DNASE1L3_ENST00000486455.1_Missense_Mutation_p.E103K|DNASE1L3_ENST00000394549.2_Missense_Mutation_p.E133K|DNASE1L3_ENST00000318316.3_Missense_Mutation_p.E133K			Q13609	DNSL3_HUMAN	deoxyribonuclease I-like 3	133					apoptosis|DNA catabolic process	nucleus	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			breast(2)|large_intestine(4)|lung(6)	12				BRCA - Breast invasive adenocarcinoma(55;0.00021)|KIRC - Kidney renal clear cell carcinoma(284;0.0445)|Kidney(284;0.0556)|OV - Ovarian serous cystadenocarcinoma(275;0.202)		ACAAAGGGCTCCCTGGAAAAC	0.522000													14	26					0	0	0.004007	0	0
PRF1	5551	broad.mit.edu	37	10	72358712	72358712	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:72358712C>T	ENST00000441259.1	-	3	925	c.765G>A	c.(763-765)gaG>gaA	p.E255E	PRF1_ENST00000373209.2_Silent_p.E255E	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	255	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						TCAGGCAGTCCTCCACCTCGT	0.617000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				10	22					0	0	0.000978	0	0
C10orf71	118461	broad.mit.edu	37	10	50531928	50531928	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:50531928C>T	ENST00000374144.3	+	3	1626	c.1338C>T	c.(1336-1338)ctC>ctT	p.L446L	C10orf71_ENST00000323868.4_Silent_p.L446L			Q711Q0	CJ071_HUMAN	chromosome 10 open reading frame 71	446										endometrium(1)	1						TCAGTAAGCTCCTGACCCCCA	0.522000													18	25					0	0	0.006122	0	0
VARS	7407	broad.mit.edu	37	6	31746792	31746792	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31746792G>A	ENST00000375663.3	-	29	4118	c.3678C>T	c.(3676-3678)ggC>ggT	p.G1226G		NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	1226					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	TGACAGGATAGCCCGAGGCAG	0.647000													56	532					0	0	0.003610	0	0
SLC36A1	206358	broad.mit.edu	37	5	150838456	150838456	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:150838456C>T	ENST00000243389.3	+	2	326	c.103C>T	c.(103-105)Ccg>Tcg	p.P35S	SLC36A1_ENST00000521351.1_3'UTR|SLC36A1_ENST00000520701.1_Missense_Mutation_p.P35S|SLC36A1_ENST00000429484.2_Missense_Mutation_p.P35S|SLC36A1_ENST00000521925.1_Missense_Mutation_p.P35S	NM_078483.2	NP_510968.2	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 1	35					cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			endometrium(5)|kidney(9)|lung(8)|skin(2)|urinary_tract(1)	25		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	CCTCTCCTCCCCGGGCTCCTA	0.577000													25	62					0	0	0.005443	0	0
HECTD3	79654	broad.mit.edu	37	1	45476265	45476265	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:45476265G>A	ENST00000372172.4	-	2	554	c.483C>T	c.(481-483)ctC>ctT	p.L161L		NM_024602.5	NP_078878.3	Q5T447	HECD3_HUMAN	HECT domain containing E3 ubiquitin protein ligase 3	161					proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm	ubiquitin-protein ligase activity			breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|stomach(1)	28	Acute lymphoblastic leukemia(166;0.155)					GCTGCCGCTGGAGGTGGTTGG	0.692000													9	24					0	0	0.004482	0	0
ANK3	288	broad.mit.edu	37	10	61829952	61829952	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:61829952C>T	ENST00000280772.1	-	37	10878	c.10687G>A	c.(10687-10689)Gaa>Aaa	p.E3563K	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3563					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGCTTAGTTTCATCTTCCCGT	0.468000													26	23					0	0	0.001512	0	0
ZCCHC12	170261	broad.mit.edu	37	X	117959676	117959676	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:117959676C>T	ENST00000310164.2	+	4	976	c.469C>T	c.(469-471)Cag>Tag	p.Q157*		NM_173798.2	NP_776159.1	Q6PEW1	ZCH12_HUMAN	zinc finger, CCHC domain containing 12	157					regulation of transcription, DNA-dependent|transcription, DNA-dependent		nucleic acid binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(2)	22						ggtgcagctccagaacgctat	0.502000													50	7					0	0	0.003610	0	0
DNAH11	8701	broad.mit.edu	37	7	21737789	21737789	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:21737789C>T	ENST00000328843.6	+	37	6190	c.6159C>T	c.(6157-6159)ttC>ttT	p.F2053F	DNAH11_ENST00000409508.3_Silent_p.F2046F			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2053	AAA 1 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CCCGAAAGTTCATTACGTTGT	0.433000									Kartagener syndrome				16	48					0	0	0.004990	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284803	52284803	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:52284803C>T	ENST00000301190.6	+	5	1300	c.1073C>T	c.(1072-1074)tCc>tTc	p.S358F	ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000538991.1_Intron|ANKRD33_ENST00000340970.4_Intron	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	234										endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		GTTCCCCAGTCCCCGCCAGGG	0.642000													9	23					0	0	0.006214	0	0
TTN	7273	broad.mit.edu	37	2	179399168	179399168	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:179399168C>T	ENST00000589042.1	-	358	102398	c.102174G>A	c.(102172-102174)agG>agA	p.R34058R	TTN-AS1_ENST00000585487.1_RNA|TTN-AS1_ENST00000450692.2_RNA|TTN_ENST00000359218.5_Silent_p.R25118R|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000589842.1_RNA|TTN-AS1_ENST00000585358.1_RNA|TTN-AS1_ENST00000431259.2_RNA|TTN-AS1_ENST00000590040.1_RNA|TTN-AS1_ENST00000592836.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN-AS1_ENST00000588257.1_RNA|TTN_ENST00000342175.6_Silent_p.R25185R|TTN-AS1_ENST00000589434.1_RNA|TTN_ENST00000591111.1_Silent_p.R32417R|TTN-AS1_ENST00000588716.1_RNA|TTN_ENST00000460472.2_Silent_p.R24993R|TTN_ENST00000342992.6_Silent_p.R31490R|TTN-AS1_ENST00000588244.1_RNA|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000589391.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000588804.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000591867.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000442329.2_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000591466.1_RNA|TTN-AS1_ENST00000592182.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	32417							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity	p.R25118R(1)|p.R25185R(1)|p.R31490R(1)|p.R24993R(1)|p.R31488R(1)		NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCGAGATTTCCTCTCTTTCA	0.413000													36	51					0	0	0.004878	0	0
SNHG14	104472715	broad.mit.edu	37	15	25442625	25442625	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:25442625C>T	ENST00000424208.1	+	0	1601				SNHG14_ENST00000456576.1_RNA|SNHG14_ENST00000424333.1_RNA	NR_003305.1																						AAGCTCAGGCCCTTCCTGATG	0.602000													11	10					0	0	0.000673	0	0
DSCAML1	57453	broad.mit.edu	37	11	117329477	117329477	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:117329477C>T	ENST00000321322.6	-	19	3742	c.3741G>A	c.(3739-3741)aaG>aaA	p.K1247K	DSCAML1_ENST00000527706.1_Silent_p.K977K	NM_020693.2	NP_065744.2	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1187	Fibronectin type-III 4.				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			breast(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(24)|lung(49)|ovary(6)|pancreas(1)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	110	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		CACCGTCCTCCTTGGTCTGGA	0.647000													7	7					0	0	0.003080	0	0
CDX1	1044	broad.mit.edu	37	5	149563178	149563178	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:149563178C>T	ENST00000231656.8	+	3	815	c.733C>T	c.(733-735)Ccc>Tcc	p.P245S		NM_001804.2	NP_001795.2	P47902	CDX1_HUMAN	caudal type homeobox 1	245						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(2)|lung(1)|ovary(1)	5		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GGGCCTGTGTCCCAGCAACAC	0.657000													15	19					0	0	0.001523	0	0
REG1P	5969	broad.mit.edu	37	2	79363152	79363152	+	RNA	SNP	C	C	T	rs75820374	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:79363152C>T	ENST00000444841.1	-	0	1186																											ATCCAATGTCCCAGGATTTGT	0.522000													4	12					0	0	0.000602	0	0
IFNLR1	163702	broad.mit.edu	37	1	24484157	24484157	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:24484157G>A	ENST00000327535.1	-	7	1038	c.1026C>T	c.(1024-1026)ccC>ccT	p.P342P	IFNLR1_ENST00000374421.3_Silent_p.P313P|IFNLR1_ENST00000327575.2_3'UTR	NM_170743.3|NM_173064.2	NP_734464.1|NP_775087.1			interferon, lambda receptor 1																		GTTCAATGTAGGGCTGGAAGC	0.617000													32	59					0	0	0.001786	0	0
CBLN2	147381	broad.mit.edu	37	18	70205894	70205894	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:70205894G>A	ENST00000269503.4	-	4	1244	c.471C>T	c.(469-471)acC>acT	p.T157T	CBLN2_ENST00000585159.1_Silent_p.T157T|CBLN2_ENST00000581073.1_Silent_p.T43T|CBLN2_ENST00000584764.1_Silent_p.T41T|CBLN2_ENST00000583651.1_5'UTR	NM_182511.3	NP_872317.1	Q8IUK8	CBLN2_HUMAN	cerebellin 2 precursor	157	C1q.					integral to membrane				endometrium(2)|lung(15)	17		Esophageal squamous(42;0.131)				CCACCTGGATGGTTTGTCTGT	0.453000													16	36					0	0	0.007413	0	0
GRM7	2917	broad.mit.edu	37	3	7456764	7456764	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:7456764G>A	ENST00000486284.1	+	5	1362	c.1088G>A	c.(1087-1089)tGg>tAg	p.W363*	GRM7_ENST00000357716.4_Nonsense_Mutation_p.W363*|GRM7_ENST00000402647.2_Nonsense_Mutation_p.W363*|GRM7_ENST00000389336.4_Nonsense_Mutation_p.W363*|GRM7_ENST00000403881.1_Nonsense_Mutation_p.W363*	NM_181874.2	NP_870989.1	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7	363					negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(35)|ovary(4)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	76					L-Glutamic Acid(DB00142)	AGAAATGTATGGTTTGCCGAA	0.413000													11	23					0	0	0.001368	0	0
BAGE2	85319	broad.mit.edu	37	21	11098827	11098827	+	RNA	SNP	C	C	T	rs79274499	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:11098827C>T	ENST00000470054.1	-	0	98									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		ccatccagagcgagacgagcc	0.637000													5	12					0	0	0.000602	0	0
GALNT15	117248	broad.mit.edu	37	3	16252704	16252704	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:16252704C>T	ENST00000339732.5	+	5	1656	c.1153C>T	c.(1153-1155)Ctt>Ttt	p.L385F	GALNT15_ENST00000437509.1_Missense_Mutation_p.L385F	NM_054110.4	NP_473451.3			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15																		GTATGACTCTCTTATGTCGCT	0.542000													21	61					0	0	0.002780	0	0
ATP5A1	498	broad.mit.edu	37	18	43667373	43667373	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:43667373G>A	ENST00000593152.2	-	7	1274	c.735C>T	c.(733-735)tcC>tcT	p.S245S	ATP5A1_ENST00000590665.1_Silent_p.S273S|ATP5A1_ENST00000398752.6_Silent_p.S295S|ATP5A1_ENST00000282050.2_Silent_p.S295S	NM_001257335.1	NP_001244264.1	P25705	ATPA_HUMAN	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	295					ATP hydrolysis coupled proton transport|embryo development|lipid metabolic process|negative regulation of endothelial cell proliferation|respiratory electron transport chain	mitochondrial matrix|plasma membrane	ATP binding|eukaryotic cell surface binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|MHC class I protein binding|proton-transporting ATPase activity, rotational mechanism			breast(2)|endometrium(1)|kidney(2)|large_intestine(7)|lung(8)|skin(1)|urinary_tract(1)	22						ACTCTCCCATGGAACAGCCAG	0.418000													28	19					0	0	0.002445	0	0
DKK1	22943	broad.mit.edu	37	10	54074346	54074346	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:54074346G>A	ENST00000373970.3	+	1	291	c.152G>A	c.(151-153)gGc>gAc	p.G51D		NM_012242.2	NP_036374.1	O94907	DKK1_HUMAN	dickkopf WNT signaling pathway inhibitor 1	51					negative regulation of peptidyl-serine phosphorylation|negative regulation of protein complex assembly|negative regulation of transcription from RNA polymerase II promoter|positive regulation of heart induction by negative regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization	extracellular space|plasma membrane	growth factor activity|low-density lipoprotein particle receptor binding|receptor antagonist activity|signal transducer activity			kidney(2)|large_intestine(4)|lung(7)|ovary(1)|upper_aerodigestive_tract(2)	16						CCGCTGGGCGGCGCTGCGGGG	0.657000											OREG0020191	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	13	26					0	0	0.002450	0	0
RNF181	51255	broad.mit.edu	37	2	85824049	85824049	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:85824049A>C	ENST00000441634.1	+	3	361	c.322A>C	c.(322-324)Agc>Cgc	p.S108R	RNF181_ENST00000306368.4_Missense_Mutation_p.S108R			Q9P0P0	RN181_HUMAN	ring finger protein 181	108							ligase activity|zinc ion binding			lung(1)|stomach(1)	2						GCCCTGGCTAAGCAAGGTACT	0.527000													32	66					0	0	0.001512	0	0
DDX3X	1654	broad.mit.edu	37	X	41204721	41204721	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:41204721C>T	ENST00000399959.2	+	12	2090	c.1235C>T	c.(1234-1236)tCt>tTt	p.S412F	DDX3X_ENST00000478993.1_3'UTR|DDX3X_ENST00000441189.2_Intron|DDX3X_ENST00000542215.1_3'UTR|DDX3X_ENST00000457138.2_Missense_Mutation_p.S396F	NM_001193416.1|NM_001193417.1|NM_001356.3	NP_001180345.1|NP_001180346.1|NP_001347.3	O00571	DDX3X_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked	412	Necessary for interaction with XPO1.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding	p.S412F(2)		NS(3)|breast(8)|central_nervous_system(36)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(3)|lung(7)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	84						GGCTCTACCTCTGAAAACATC	0.353000										HNSCC(61;0.18)			24	4					0	0	0.005443	0	0
ETV7	51513	broad.mit.edu	37	6	36334473	36334473	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:36334473C>T	ENST00000373738.1	-	7	1655	c.810G>A	c.(808-810)caG>caA	p.Q270Q	ETV7_ENST00000339796.5_Intron|ETV7_ENST00000538992.1_Silent_p.Q174Q|ETV7_ENST00000373737.4_Silent_p.Q248Q|ETV7_ENST00000340181.4_Silent_p.Q325Q	NM_001207036.1	NP_001193965.1	Q9Y603	ETV7_HUMAN	ets variant 7	325					organ morphogenesis|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)|skin(4)	10						TGTCCTGCTCCTGGCTCTCCA	0.572000													22	129					0	0	0.002780	0	0
HARBI1	283254	broad.mit.edu	37	11	46637407	46637407	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:46637407G>A	ENST00000326737.3	-	2	628	c.381C>T	c.(379-381)tcC>tcT	p.S127S		NM_173811.3	NP_776172.1	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	127						cytoplasm|nucleus	metal ion binding|nuclease activity			large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)	3						GAGCCTGAATGGAGGCTTCAT	0.517000													48	84					0	0	0.003610	0	0
CUL9	23113	broad.mit.edu	37	6	43154031	43154031	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43154031C>T	ENST00000252050.4	+	4	1173	c.1089C>T	c.(1087-1089)ttC>ttT	p.F363F	CUL9_ENST00000354495.3_Silent_p.F363F|CUL9_ENST00000372647.2_Silent_p.F363F	NM_015089.2	NP_055904.1	Q8IWT3	CUL9_HUMAN	cullin 9	363					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|liver(1)|lung(30)|ovary(5)|prostate(3)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(4)	92						GGTGGGTCTTCCGCCAGCGCT	0.577000													17	138					0	0	0.001523	0	0
IGSF9	57549	broad.mit.edu	37	1	159904006	159904006	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:159904006C>T	ENST00000368094.1	-	9	1275	c.1078G>A	c.(1078-1080)Gat>Aat	p.D360N	IGSF9_ENST00000361509.3_Missense_Mutation_p.D344N	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	360	Ig-like 4.					cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			GCCTTTCCATCCTTGGTCCAG	0.612000													22	10					0	0	0.007291	0	0
LRRC7	57554	broad.mit.edu	37	1	70460305	70460305	+	Silent	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:70460305T>C	ENST00000310961.5	+	12	1312	c.894T>C	c.(892-894)aaT>aaC	p.N298N	LRRC7_ENST00000035383.5_Silent_p.N293N|LRRC7_ENST00000415775.2_5'UTR			Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	293						centrosome|focal adhesion|nucleolus	protein binding			breast(11)|central_nervous_system(3)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(25)|liver(3)|lung(81)|ovary(9)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	162						TGCTACCCAATACAATTGGAA	0.328000													37	77					0	0	0.006999	0	0
OR2T27	403239	broad.mit.edu	37	1	248814064	248814064	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:248814064C>T	ENST00000344889.3	-	1	121	c.122G>A	c.(121-123)aGc>aAc	p.S41N		NM_001001824.1	NP_001001824.1	Q8NH04	O2T27_HUMAN	olfactory receptor, family 2, subfamily T, member 27	41					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(20)|skin(3)|stomach(1)	32	all_cancers(71;1.15e-05)|all_epithelial(71;5.29e-06)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.089)|Lung NSC(105;0.0969)|Melanoma(84;0.199)	all_cancers(173;0.237)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GACCACGTTGCTGGCTATGGA	0.522000													12	57					0	0	0.003163	0	0
GPR149	344758	broad.mit.edu	37	3	154055952	154055952	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:154055952C>T	ENST00000389740.2	-	4	1831	c.1732G>A	c.(1732-1734)Gaa>Aaa	p.E578K		NM_001038705.1	NP_001033794.1	Q86SP6	GP149_HUMAN	G protein-coupled receptor 149	578						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(22)|ovary(7)|prostate(1)|skin(1)|urinary_tract(2)	47			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TTTTGCCCTTCTGCGCTTACC	0.448000													52	113					0	0	0.003610	0	0
TXNDC2	84203	broad.mit.edu	37	18	9887778	9887778	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:9887778C>T	ENST00000306084.6	+	2	1501	c.1302C>T	c.(1300-1302)atC>atT	p.I434I	TXNDC2_ENST00000357775.4_Silent_p.I367I|TXNDC2_ENST00000577697.1_3'UTR|TXNDC2_ENST00000536353.2_3'UTR	NM_001098529.1	NP_001091999.1	Q86VQ3	TXND2_HUMAN	thioredoxin domain containing 2 (spermatozoa)	434	22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.|Thioredoxin.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(2)|pancreas(1)|skin(7)|urinary_tract(1)	31						AGGGTGACATCCTAAAGCCTG	0.547000													9	40					0	0	0.004482	0	0
MUC7	4589	broad.mit.edu	37	4	71347507	71347507	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:71347507C>T	ENST00000413702.1	+	4	1334	c.1046C>T	c.(1045-1047)tCa>tTa	p.S349L	MUC7_ENST00000304887.5_Missense_Mutation_p.S349L|MUC7_ENST00000456088.1_Missense_Mutation_p.S349L	NM_001145006.1	NP_001138478.1	Q8TAX7	MUC7_HUMAN	mucin 7, secreted	349						extracellular region	protein binding			central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(2)|lung(23)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42			Lung(101;0.211)			CAACCAACTTCAGCTCCTGGC	0.378000													31	42					0	0	0.001786	0	0
ASMT	438	broad.mit.edu	37	X	1761794	1761794	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:1761794G>A	ENST00000381241.3	+	9	1208	c.1009G>A	c.(1009-1011)Ggg>Agg	p.G337R	ASMT_ENST00000381229.4_Missense_Mutation_p.G309R|ASMT_ENST00000381233.3_Missense_Mutation_p.G262R	NM_001171038.1|NM_004043.2	NP_001164509.1|NP_004034.2	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	309					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)|skin(1)	16		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GCAGACGGAAGGGCAGGAGAG	0.517000													25	117					0	0	0.003954	0	0
HMCN1	83872	broad.mit.edu	37	1	186088383	186088383	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:186088383G>A	ENST00000271588.4	+	78	12138	c.11909G>A	c.(11908-11910)aGg>aAg	p.R3970K	HMCN1_ENST00000367492.2_Missense_Mutation_p.R3970K	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3970	Ig-like C2-type 38.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TGTGTCGCTAGGAATGCGGCT	0.408000													35	165					0	0	0.002222	0	0
SPAG17	200162	broad.mit.edu	37	1	118514651	118514651	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:118514651C>T	ENST00000336338.5	-	45	6226	c.6161G>A	c.(6160-6162)gGa>gAa	p.G2054E	SPAG17_ENST00000492438.1_5'UTR	NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	2054						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		GTTCACTTTTCCTCCAACAGA	0.373000													15	37					0	0	0.004007	0	0
FOLH1	2346	broad.mit.edu	37	11	49229944	49229944	+	Translation_Start_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:49229944G>A	ENST00000340334.7	-	0	244				FOLH1_ENST00000343844.4_De_novo_Start_InFrame|FOLH1_ENST00000256999.2_Silent_p.H6H|FOLH1_ENST00000356696.3_Silent_p.H6H	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1						proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	AGTCGGTTTCGTGAAGGAGAT	0.711000													5	9					0	0	0.004482	0	0
CALCOCO1	57658	broad.mit.edu	37	12	54107577	54107577	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:54107577G>A	ENST00000548263.1	-	13	1747	c.1699C>T	c.(1699-1701)Cct>Tct	p.P567S	CALCOCO1_ENST00000550804.1_Missense_Mutation_p.P567S|CALCOCO1_ENST00000262059.4_Missense_Mutation_p.P567S|CALCOCO1_ENST00000430117.2_Missense_Mutation_p.P482S			Q9P1Z2	CACO1_HUMAN	calcium binding and coiled-coil domain 1	567	C-terminal AD (CTNNB1 binding site) (By similarity).				steroid hormone receptor signaling pathway|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm	armadillo repeat domain binding|beta-catenin binding|ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|sequence-specific DNA binding|transcription regulatory region DNA binding			NS(2)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(14)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	28						GCCTCTCGAGGCCCAGCAGGA	0.612000													33	56					0	0	0.003755	0	0
IGSF11	152404	broad.mit.edu	37	3	118621455	118621455	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:118621455G>A	ENST00000354673.2	-	9	1585	c.1205C>T	c.(1204-1206)tCc>tTc	p.S402F	IGSF11_ENST00000393775.2_Missense_Mutation_p.S403F|IGSF11_ENST00000489689.1_Missense_Mutation_p.S379F|IGSF11_ENST00000425327.2_Missense_Mutation_p.S402F|IGSF11_ENST00000441144.2_Missense_Mutation_p.S378F|IGSF11_ENST00000491903.1_Missense_Mutation_p.S375F	NM_152538.2	NP_689751.2	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11	403					cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|liver(1)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	34						GATGGTGTAGGAATGAGTGTG	0.547000													23	62					0	0	0.002299	0	0
LAMC2	3918	broad.mit.edu	37	1	183206618	183206618	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:183206618G>A	ENST00000264144.4	+	18	2798	c.2733G>A	c.(2731-2733)caG>caA	p.Q911Q	LAMC2_ENST00000493293.1_Silent_p.Q911Q	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	911	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						AGCTCTTACAGAATGGAAAAA	0.393000													41	18					0	0	0.002222	0	0
COL16A1	1307	broad.mit.edu	37	1	32133812	32133812	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:32133812G>A	ENST00000373672.3	-	51	3773	c.3257C>T	c.(3256-3258)cCa>cTa	p.P1086L	COL16A1_ENST00000271069.6_Missense_Mutation_p.P1086L	NM_001856.3	NP_001847.3	Q07092	COGA1_HUMAN	collagen, type XVI, alpha 1	1086	Triple-helical region 2 (COL2) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			breast(4)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(7)|lung(15)|ovary(8)|prostate(4)	48		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		TGGTTGCCCTGGAGGACCCTG	0.602000													17	38					0	0	0.002299	0	0
COL2A1	1280	broad.mit.edu	37	12	48380960	48380960	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:48380960C>T	ENST00000380518.3	-	21	1431		c.e21-1		COL2A1_ENST00000493991.1_Splice_Site|COL2A1_ENST00000337299.6_Splice_Site	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1						axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	CAGGAGCACCCTGTGGGCATG	0.647000													24	55					0	0	0.002780	0	0
SPERT	220082	broad.mit.edu	37	13	46287346	46287346	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:46287346C>T	ENST00000378966.3	+	2	494	c.78C>T	c.(76-78)ctC>ctT	p.L26L	SPERT_ENST00000310521.1_Silent_p.L62L			Q8NA61	SPERT_HUMAN	spermatid associated	62						cytoplasmic membrane-bounded vesicle				NS(1)|central_nervous_system(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(1)	15		Breast(56;0.000819)|Lung NSC(96;0.00227)|Prostate(109;0.00703)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.26e-05)		TCCCGAGGCTCCACAACTTGT	0.647000													10	8					0	0	0.000978	0	0
CDS1	1040	broad.mit.edu	37	4	85525463	85525463	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:85525463C>T	ENST00000295887.5	+	2	608	c.185C>T	c.(184-186)cCa>cTa	p.P62L		NM_001263.3	NP_001254.2	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	62					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|ovary(1)	20		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		CCGGAAATTCCACCATCCTCA	0.343000													23	29					0	0	0.003330	0	0
RPS6KA4	8986	broad.mit.edu	37	11	64132833	64132833	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:64132833C>T	ENST00000528057.1	+	9	1055	c.967C>T	c.(967-969)Cgc>Tgc	p.R323C	RPS6KA4_ENST00000334205.4_Missense_Mutation_p.R323C|RPS6KA4_ENST00000294261.4_Missense_Mutation_p.R323C	NM_001006944.1	NP_001006945.1	O75676	KS6A4_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 4	323	AGC-kinase C-terminal.				axon guidance|histone phosphorylation|interleukin-1-mediated signaling pathway|intracellular protein kinase cascade|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|magnesium ion binding|mitogen-activated protein kinase p38 binding|ribosomal protein S6 kinase activity			breast(1)|endometrium(3)|lung(7)|ovary(1)|prostate(1)	13						GCCCCAAATCCGCTCAGAGCT	0.622000													15	23					0	0	0.003163	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3140185	3140185	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:3140185G>A	ENST00000252463.2	-	5	1172	c.1085C>T	c.(1084-1086)tCg>tTg	p.S362L	ZSCAN10_ENST00000538082.2_Missense_Mutation_p.S280L|ZSCAN10_ENST00000575108.1_Missense_Mutation_p.S23L	NM_032805.1	NP_116194.1	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	362					negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|cervix(3)|endometrium(3)|kidney(1)|lung(8)|ovary(2)|prostate(1)|skin(4)|urinary_tract(1)	24						GCTCAGGTGCGAGCTCTGGCG	0.692000													19	34					0	0	0.001523	0	0
CLEC10A	10462	broad.mit.edu	37	17	6979005	6979005	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:6979005C>T	ENST00000576617.1	-	7	908	c.639G>A	c.(637-639)agG>agA	p.R213R	CLEC10A_ENST00000416562.2_Intron|CLEC10A_ENST00000254868.4_Intron|CLEC10A_ENST00000571664.1_Intron			Q8IUN9	CLC10_HUMAN	C-type lectin domain family 10, member A	0	C-type lectin.				endocytosis|innate immune response	integral to membrane|plasma membrane	sugar binding			central_nervous_system(2)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	10						gaaccattTCCCTAAATGGGA	0.512000													19	15					0	0	0.006122	0	0
SPHKAP	80309	broad.mit.edu	37	2	228884064	228884064	+	Silent	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:228884064A>G	ENST00000392056.3	-	7	1552	c.1506T>C	c.(1504-1506)tgT>tgC	p.C502C	SPHKAP_ENST00000344657.5_Silent_p.C502C	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	502						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CAGTGGCTGCACAAGCTAACG	0.527000													8	10					0	0	0.006214	0	0
POTEH	23784	broad.mit.edu	37	22	16267070	16267070	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:16267070C>T	ENST00000343518.6	-	9	1430	c.1379G>A	c.(1378-1380)gGa>gAa	p.G460E		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	460										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						ATGAGTACTTCCGTGCTTCTT	0.358000													26	227					0	0	0.002445	0	0
SCAND3	114821	broad.mit.edu	37	6	28543816	28543816	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:28543816C>T	ENST00000452236.2	-	3	1283	c.666G>A	c.(664-666)atG>atA	p.M222I	SCAND3_ENST00000530247.1_5'UTR	NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	222					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						ACTTTTCTCTCATGTTTTCTG	0.348000													21	108					0	0	0.001882	0	0
PHACTR1	221692	broad.mit.edu	37	6	12933957	12933957	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:12933957G>A	ENST00000379348.2	+	4	520	c.343G>A	c.(343-345)Gaa>Aaa	p.E115K	PHACTR1_ENST00000379350.1_Intron|PHACTR1_ENST00000332995.7_Intron			Q9C0D0	PHAR1_HUMAN	phosphatase and actin regulator 1	0						cell junction|cytoplasm|synapse	actin binding|protein phosphatase inhibitor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(10)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	26	Breast(50;0.0427)|Ovarian(93;0.12)	all_hematologic(90;0.122)|Lung SC(78;0.195)	Epithelial(50;0.146)|BRCA - Breast invasive adenocarcinoma(129;0.239)			GTGTTCCCTGGAAAACCACGG	0.537000													29	101					0	0	0.006320	0	0
ABCB5	340273	broad.mit.edu	37	7	20682906	20682906	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:20682906G>A	ENST00000404938.2	+	6	1066	c.414G>A	c.(412-414)agG>agA	p.R138R		NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	322	ABC transporter 1.				regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						AGACCAAGAGGATTCGAAAAC	0.428000													13	25					0	0	0.001855	0	0
CCBE1	147372	broad.mit.edu	37	18	57103244	57103244	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:57103244C>T	ENST00000439986.4	-	11	1154	c.1117G>A	c.(1117-1119)Gaa>Aaa	p.E373K	CCBE1_ENST00000398179.2_Missense_Mutation_p.E102K	NM_133459.3	NP_597716.1	Q6UXH8	CCBE1_HUMAN	collagen and calcium binding EGF domains 1	373					lymphangiogenesis|sprouting angiogenesis|venous blood vessel morphogenesis	collagen	calcium ion binding			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|prostate(1)|skin(3)	24		Colorectal(73;0.175)				CTGGGAAATTCCTGAGGTAAA	0.532000													50	68					0	0	0.003610	0	0
MPEG1	219972	broad.mit.edu	37	11	58978379	58978379	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:58978379C>T	ENST00000361050.3	-	1	2045	c.1960G>A	c.(1960-1962)Gga>Aga	p.G654R		NM_001039396.1	NP_001034485.1	Q2M385	MPEG1_HUMAN	macrophage expressed 1	654						integral to membrane				NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(21)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		all_epithelial(135;0.125)				GCAGCCCCTCCTGACAGACCA	0.567000													37	72					0	0	0.001951	0	0
SLC9C1	285335	broad.mit.edu	37	3	111918168	111918168	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:111918168C>T	ENST00000305815.5	-	20	2775	c.2523_splice	c.e20+1	p.K841_splice	SLC9C1_ENST00000487372.1_Splice_Site_p.K793_splice	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	841					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										TTTGCCTTACCTTATTAATTC	0.308000													12	68					0	0	0.001855	0	0
BAG6	7917	broad.mit.edu	37	6	31617103	31617103	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31617103G>T	ENST00000404765.2	-	4	585	c.296C>A	c.(295-297)tCt>tAt	p.S99Y	BAG6_ENST00000211379.5_Missense_Mutation_p.S99Y|BAG6_ENST00000362049.6_Missense_Mutation_p.S99Y|BAG6_ENST00000439687.2_Missense_Mutation_p.S99Y|BAG6_ENST00000375976.4_Missense_Mutation_p.S99Y|BAG6_ENST00000375964.6_Missense_Mutation_p.S99Y			P46379	BAG6_HUMAN	BCL2-associated athanogene 6	99					apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(18)|ovary(2)|pancreas(2)|skin(3)|urinary_tract(2)	36						CGTCCCAGAAGATGCCCCAGA	0.577000													58	988					1.83081e-24	3.135e-24	0.003610	1	0
TTN	7273	broad.mit.edu	37	2	179649020	179649020	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:179649020G>A	ENST00000589042.1	-	16	2776	c.2552C>T	c.(2551-2553)tCt>tTt	p.S851F	TTN_ENST00000359218.5_Missense_Mutation_p.S805F|TTN_ENST00000342175.6_Missense_Mutation_p.S805F|TTN_ENST00000591111.1_Missense_Mutation_p.S851F|TTN_ENST00000460472.2_Missense_Mutation_p.S805F|TTN_ENST00000342992.6_Missense_Mutation_p.S851F|TTN_ENST00000360870.5_Missense_Mutation_p.S851F	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	851							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCTGAGCAGAAGATGTGGC	0.473000													13	24					0	0	0.001368	0	0
CACNA1A	773	broad.mit.edu	37	19	13443705	13443705	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:13443705C>T	ENST00000360228.5	-	9	1232	c.1233G>A	c.(1231-1233)ggG>ggA	p.G411G	CACNA1A_ENST00000573710.2_Silent_p.G411G	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	411					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	GCCTCTGCTCCCCGTCAGTTT	0.567000													8	16					0	0	0.006214	0	0
RAP1GAP2	23108	broad.mit.edu	37	17	2883636	2883636	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:2883636C>T	ENST00000254695.8	+	9	742	c.652C>T	c.(652-654)Ccc>Tcc	p.P218S	RAP1GAP2_ENST00000542807.1_Missense_Mutation_p.P218S|RAP1GAP2_ENST00000366401.4_Missense_Mutation_p.P203S|RAP1GAP2_ENST00000540393.2_Missense_Mutation_p.P199S	NM_015085.4	NP_055900.4	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2	218					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	11						GAGCAAGCTTCCCAGTGTCCC	0.547000													11	21					0	0	0.001855	0	0
PPP1R26	9858	broad.mit.edu	37	9	138379983	138379983	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:138379983C>T	ENST00000356818.2	+	4	4176	c.3627C>T	c.(3625-3627)gtC>gtT	p.V1209V	PPP1R26_ENST00000401470.3_Silent_p.V1209V|PPP1R26_ENST00000605660.1_Silent_p.V1209V|PPP1R26_ENST00000602993.1_Intron|PPP1R26_ENST00000605286.1_Silent_p.V1209V|PPP1R26_ENST00000604351.1_Silent_p.V1209V	NM_014811.3	NP_055626.3	Q5T8A7	K0649_HUMAN	protein phosphatase 1, regulatory subunit 26	1209						nucleolus	protein binding										TAGTGAAGGTCTAAGCCCTCG	0.617000													23	4					0	0	0.002780	0	0
KRT37	8688	broad.mit.edu	37	17	39580567	39580567	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:39580567G>A	ENST00000225550.3	-	1	208	c.209C>T	c.(208-210)cCc>cTc	p.P70L	AC003958.2_ENST00000432258.1_RNA	NM_003770.4	NP_003761.3	O76014	KRT37_HUMAN	keratin 37	70	Head.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(6)|skin(3)	25		Breast(137;0.000496)				ACTGGTTGGGGGCAGACAGAG	0.622000													12	33					0	0	0.003163	0	0
SLC26A6	65010	broad.mit.edu	37	3	48669454	48669454	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:48669454G>A	ENST00000455886.2	-	5	552	c.505C>T	c.(505-507)Cgg>Tgg	p.R169W	SLC26A6_ENST00000358747.6_Silent_p.F182F|SLC26A6_ENST00000482282.1_5'UTR|SLC26A6_ENST00000383733.3_Silent_p.F203F|SLC26A6_ENST00000420764.2_Silent_p.F203F|SLC26A6_ENST00000337000.8_Intron|SLC26A6_ENST00000395550.2_Silent_p.F203F					solute carrier family 26 (anion exchanger), member 6										SLC26A6/PRKAR2A(2)	NS(1)|breast(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(11)|ovary(1)	19				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00609)		CCACGAAGCCGAAGTGGATCA	0.612000													10	57					0	0	0.001368	0	0
ZNF558	148156	broad.mit.edu	37	19	8931904	8931904	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:8931904G>A	ENST00000601372.1	-	7	910	c.199C>T	c.(199-201)Ctg>Ttg	p.L67L	ZNF558_ENST00000444186.2_5'UTR|ZNF558_ENST00000301475.1_Silent_p.L67L			Q96NG5	ZN558_HUMAN	zinc finger protein 558	67	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(7)|prostate(1)|skin(1)	15						TCCCTGTACAGTGTCCTTTGG	0.517000													20	19					0	0	0.001216	0	0
C1QTNF1	114897	broad.mit.edu	37	17	77043684	77043684	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:77043684G>A	ENST00000339142.2	+	5	915	c.360G>A	c.(358-360)ggG>ggA	p.G120G	C1QTNF1_ENST00000580474.1_Silent_p.G120G|C1QTNF1_ENST00000578229.1_Silent_p.G38G|C1QTNF1_ENST00000582625.1_3'UTR|C1QTNF1_ENST00000583904.1_Silent_p.G120G|C1QTNF1_ENST00000581774.1_Silent_p.G120G|C1QTNF1_ENST00000580454.1_Silent_p.G120G|C1QTNF1_ENST00000311661.4_Silent_p.G38G|C1QTNF1_ENST00000579760.1_Silent_p.G120G|C1QTNF1_ENST00000354124.3_Silent_p.G130G|C1QTNF1_ENST00000392445.2_Silent_p.G120G	NM_198593.3	NP_940995.1	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	120	Collagen-like.					collagen				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(2)	14			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			GCTCAGCAGGGGCCAGGGGCC	0.622000													56	37					0	0	0.003610	0	0
GPR61	83873	broad.mit.edu	37	1	110085662	110085662	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:110085662C>T	ENST00000527748.1	+	2	701	c.18C>T	c.(16-18)atC>atT	p.I6I	RP5-1160K1.8_ENST00000526411.1_RNA	NM_031936.4	NP_114142.3	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	6						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(9)|stomach(1)|urinary_tract(1)	23		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		CCTCACCCATCCCCCAGTCAT	0.647000													11	15					0	0	0.000978	0	0
TAOK1	57551	broad.mit.edu	37	17	27816697	27816697	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:27816697C>T	ENST00000261716.3	+	9	1190	c.671C>T	c.(670-672)cCt>cTt	p.P224L	TAOK1_ENST00000536202.1_Missense_Mutation_p.P224L	NM_020791.2	NP_065842.1	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	224	Protein kinase.				mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28			Colorectal(6;0.198)			AGGAAGCCTCCTTTATTTAAT	0.348000													20	63					0	0	0.001523	0	0
DDHD1	80821	broad.mit.edu	37	14	53558541	53558541	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:53558541C>T	ENST00000357758.3	-	4	1434	c.1251G>A	c.(1249-1251)caG>caA	p.Q417Q	DDHD1_ENST00000395606.1_Silent_p.Q424Q|DDHD1_ENST00000323669.5_Silent_p.Q417Q	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1	417					lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					GGTCCATTTTCTGCCCAATGC	0.373000													27	42					0	0	0.002096	0	0
PLA2R1	22925	broad.mit.edu	37	2	160833917	160833917	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:160833917G>A	ENST00000283243.7	-	15	2485	c.2279C>T	c.(2278-2280)tCg>tTg	p.S760L	PLA2R1_ENST00000392771.1_Missense_Mutation_p.S760L	NM_001195641.1|NM_007366.4	NP_001182570.1|NP_031392.3	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1, 180kDa	760	C-type lectin 4.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding		PLA2R1/RBMS1(2)	central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(17)|lung(20)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(1)	60						GTCTAAAAACGAAGAGACAAC	0.388000													14	23					0	0	0.001855	0	0
CARD11	84433	broad.mit.edu	37	7	2946340	2946340	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2946340G>A	ENST00000396946.4	-	25	3800	c.3397C>T	c.(3397-3399)Cgc>Tgc	p.R1133C		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	1133	Guanylate kinase-like.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TTGACAACGCGGAGCAGCTCC	0.662000			Mis		DLBCL								22	104					0	0	0.001882	0	0
CACNA1G	8913	broad.mit.edu	37	17	48683279	48683279	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:48683279C>T	ENST00000352832.5	+	22	4620	c.4248C>T	c.(4246-4248)ttC>ttT	p.F1416F	CACNA1G_ENST00000502264.1_Silent_p.F1416F|CACNA1G_ENST00000513964.1_Silent_p.F1439F|CACNA1G_ENST00000358244.5_Silent_p.F1416F|CACNA1G_ENST00000416767.4_Silent_p.F1439F|CACNA1G_ENST00000442258.2_Silent_p.F1416F|CACNA1G_ENST00000359106.5_Silent_p.F1439F|CACNA1G_ENST00000514181.1_Silent_p.F1439F|CACNA1G_ENST00000512389.1_Silent_p.F1439F|CACNA1G_ENST00000515165.1_Silent_p.F1439F|CACNA1G_ENST00000429973.2_Silent_p.F1439F|CACNA1G_ENST00000507336.1_Silent_p.F1439F|CACNA1G_ENST00000514079.1_Silent_p.F1439F|CACNA1G_ENST00000510115.1_Silent_p.F1416F|CACNA1G_ENST00000507609.1_Silent_p.F1439F|CACNA1G_ENST00000515411.1_Silent_p.F1439F|CACNA1G_ENST00000507510.2_Silent_p.F1439F|CACNA1G_ENST00000503485.1_Silent_p.F1439F|CACNA1G_ENST00000513689.2_Silent_p.F1439F|CACNA1G_ENST00000507896.1_Silent_p.F1439F|CACNA1G_ENST00000354983.4_Silent_p.F1416F|CACNA1G_ENST00000510366.1_Silent_p.F1439F|CACNA1G_ENST00000515765.1_Silent_p.F1439F|CACNA1G_ENST00000505165.1_Silent_p.F1439F|CACNA1G_ENST00000514717.1_Silent_p.F1416F|CACNA1G_ENST00000360761.4_Silent_p.F1416F	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1439					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GGAAGTTTTTCGTGTGCCAGG	0.552000													32	26					0	0	0.003755	0	0
GSDMC	56169	broad.mit.edu	37	8	130772813	130772813	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:130772813A>C	ENST00000276708.4	-	6	1580	c.699T>G	c.(697-699)gaT>gaG	p.D233E		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	233						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						TTCTCTGTTCATCATCATCTG	0.373000													48	82					0	0	0.003610	0	0
KCNB1	3745	broad.mit.edu	37	20	47989959	47989959	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:47989959A>G	ENST00000371741.4	-	2	2304	c.2138T>C	c.(2137-2139)cTt>cCt	p.L713P		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	713					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CTTGTCCAAAAGCGTGGCACA	0.597000													17	41					0	0	0.004990	0	0
ARHGEF11	9826	broad.mit.edu	37	1	156911701	156911701	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:156911701G>A	ENST00000368194.3	-	34	4446	c.3407C>T	c.(3406-3408)cCc>cTc	p.P1136L	ARHGEF11_ENST00000361409.2_Missense_Mutation_p.P1096L|ARHGEF11_ENST00000487682.1_5'UTR|ARHGEF11_ENST00000315174.8_Missense_Mutation_p.P512L	NM_198236.2	NP_937879.1	O15085	ARHGB_HUMAN	Rho guanine nucleotide exchange factor (GEF) 11	1096					actin cytoskeleton organization|apoptosis|axon guidance|cellular component movement|cytokinesis|establishment of cell polarity|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of transcription, DNA-dependent|regulation of cell growth|regulation of Rho protein signal transduction|Rho protein signal transduction|striated muscle contraction	cytosol|Golgi apparatus|plasma membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			NS(1)|breast(3)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(27)|ovary(4)|pancreas(2)|pleura(1)|prostate(4)|skin(7)|stomach(1)|urinary_tract(2)	81	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GGGACCTGGGGGTGGAGGATG	0.647000													21	54					0	0	0.003330	0	0
SPECC1L	23384	broad.mit.edu	37	22	24720332	24720332	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:24720332G>A	ENST00000314328.9	+	6	2368	c.2083G>A	c.(2083-2085)Gat>Aat	p.D695N	SPECC1L_ENST00000437398.1_Missense_Mutation_p.D695N|KB-1896H10.1_ENST00000358654.2_Missense_Mutation_p.D695N|SPECC1L_ENST00000541492.1_Missense_Mutation_p.D695N	NM_001254733.1|NM_015330.3	NP_001241662.1|NP_056145.3	Q69YQ0	CYTSA_HUMAN	sperm antigen with calponin homology and coiled-coil domains 1-like	695					cell cycle|cell division					breast(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|ovary(1)|prostate(1)|skin(3)|stomach(2)|urinary_tract(1)	27						TGAACTTGAAGATGAAGTAGA	0.328000													33	27					0	0	0.003755	0	0
SLC24A1	9187	broad.mit.edu	37	15	65917849	65917849	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:65917849C>T	ENST00000261892.6	+	2	1718	c.1431C>T	c.(1429-1431)ttC>ttT	p.F477F	SLC24A1_ENST00000537259.1_Silent_p.F477F|SLC24A1_ENST00000546330.1_Silent_p.F477F|SLC24A1_ENST00000544319.2_Silent_p.F477F|SLC24A1_ENST00000399033.4_Silent_p.F477F|SLC24A1_ENST00000339868.6_Silent_p.F477F	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	477					response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						ACGAGTACTTCGTTCCAGCCC	0.572000													41	40					0	0	0.007835	0	0
RAI2	10742	broad.mit.edu	37	X	17818801	17818801	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:17818801C>T	ENST00000545871.1	-	3	1790	c.1330G>A	c.(1330-1332)Gaa>Aaa	p.E444K	RAI2_ENST00000360011.1_Missense_Mutation_p.E444K|RAI2_ENST00000451717.1_Missense_Mutation_p.E444K|RAI2_ENST00000415486.3_Missense_Mutation_p.E394K|RAI2_ENST00000331511.1_Missense_Mutation_p.E444K	NM_001172739.1|NM_001172743.1	NP_001166210.1|NP_001166214.1	Q9Y5P3	RAI2_HUMAN	retinoic acid induced 2	444					embryo development					breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	22	Hepatocellular(33;0.183)					ACAGCATCTTCGACAGAGACA	0.537000													80	15					0	0	0.003610	0	0
SLC13A1	6561	broad.mit.edu	37	7	122821088	122821088	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:122821088G>A	ENST00000194130.2	-	2	206	c.167C>T	c.(166-168)tCg>tTg	p.S56L	SLC13A1_ENST00000539873.1_5'UTR	NM_022444.3	NP_071889.2	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate symporter), member 1	56						integral to membrane|plasma membrane	sodium:sulfate symporter activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	45					Succinic acid(DB00139)	AGCTGTTACCGACAGAGGCAA	0.428000													16	30					0	0	0.003163	0	0
GLI1	2735	broad.mit.edu	37	12	57861832	57861832	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:57861832C>T	ENST00000228682.2	+	10	1224	c.1133C>T	c.(1132-1134)tCg>tTg	p.S378L	GLI1_ENST00000546141.1_Missense_Mutation_p.S337L|GLI1_ENST00000543426.1_Missense_Mutation_p.S250L	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	378					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			GATCCTAGCTCGCTGCGAAAA	0.552000													8	34					0	0	0.006214	0	0
MICAL2	9645	broad.mit.edu	37	11	12270730	12270730	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:12270730G>A	ENST00000256194.4	+	22	3072		c.e22-1		MICAL2_ENST00000379612.3_Splice_Site|MICAL2_ENST00000537344.1_Splice_Site|MICAL2_ENST00000527546.1_Splice_Site|MICAL2_ENST00000342902.5_Intron	NM_014632.2	NP_055447.1	O94851	MICA2_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 2							cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(6)|lung(12)|ovary(2)|prostate(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(4)	47				Epithelial(150;0.00552)		TCTTTCTAAAGGAAaagaagt	0.448000													11	30					0	0	0.001368	0	0
GSTP1	2950	broad.mit.edu	37	11	67353865	67353865	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:67353865C>T	ENST00000398606.3	+	7	699	c.450C>T	c.(448-450)tcC>tcT	p.S150S	GSTP1_ENST00000398603.1_Silent_p.S114S|GSTP1_ENST00000498765.1_3'UTR	NM_000852.3	NP_000843.1	P09211	GSTP1_HUMAN	glutathione S-transferase pi 1	150	GST C-terminal.				anti-apoptosis|cellular response to lipopolysaccharide|central nervous system development|common myeloid progenitor cell proliferation|glutathione metabolic process|negative regulation of acute inflammatory response|negative regulation of ERK1 and ERK2 cascade|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 beta production|negative regulation of JUN kinase activity|negative regulation of leukocyte proliferation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of necrotic cell death|negative regulation of nitric-oxide synthase 2 biosynthetic process|negative regulation of stress-activated MAPK cascade|negative regulation of tumor necrosis factor production|nitric oxide storage|positive regulation of superoxide anion generation|response to reactive oxygen species|xenobiotic metabolic process	cytosol|protein complex	dinitrosyl-iron complex binding|glutathione transferase activity|JUN kinase binding|kinase regulator activity|nitric oxide binding|S-nitrosoglutathione binding			central_nervous_system(1)|cervix(1)|endometrium(4)|lung(2)|ovary(1)	9					Ethacrynic acid(DB00903)|Glutathione(DB00143)	TGCAGATCTCCTTCGCTGACT	0.642000													15	57					0	0	0.004990	0	0
FAT4	79633	broad.mit.edu	37	4	126373044	126373044	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:126373044G>A	ENST00000394329.3	+	9	10886	c.10873G>A	c.(10873-10875)Ggt>Agt	p.G3625S	FAT4_ENST00000335110.5_Missense_Mutation_p.G1923S	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3625					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TAATTATTATGGTAACTTGTT	0.443000													16	30					0	0	0.004007	0	0
GPR133	283383	broad.mit.edu	37	12	131471650	131471650	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:131471650G>A	ENST00000261654.5	+	6	1060	c.501G>A	c.(499-501)tgG>tgA	p.W167*	GPR133_ENST00000535015.1_Nonsense_Mutation_p.W199*	NM_198827.3	NP_942122.2	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133	167					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(2)|endometrium(6)|kidney(1)|large_intestine(12)|lung(20)|ovary(3)|pancreas(6)|prostate(6)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(4)	67	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GCCCCTATTGGACTCATGTCC	0.493000													15	35					0	0	0.003163	0	0
KIF1B	23095	broad.mit.edu	37	1	10412779	10412779	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:10412779C>T	ENST00000377086.1	+	38	4242	c.4040C>T	c.(4039-4041)tCc>tTc	p.S1347F	KIF1B_ENST00000465635.1_3'UTR|KIF1B_ENST00000263934.6_Missense_Mutation_p.S1301F|KIF1B_ENST00000377081.1_Missense_Mutation_p.S1347F			O60333	KIF1B_HUMAN	kinesin family member 1B	1347					anterograde axon cargo transport|apoptosis|neuromuscular synaptic transmission|neuron-neuron synaptic transmission	cytoplasmic vesicle membrane|microtubule|microtubule associated complex|mitochondrion	ATP binding|ATPase activity|kinesin binding|microtubule motor activity|protein binding			breast(2)|endometrium(7)|kidney(8)|large_intestine(9)|lung(29)|ovary(3)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(2)	71	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.2e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0259)|Colorectal(212;9.79e-07)|COAD - Colon adenocarcinoma(227;0.000143)|BRCA - Breast invasive adenocarcinoma(304;0.000413)|Kidney(185;0.00134)|KIRC - Kidney renal clear cell carcinoma(229;0.0037)|STAD - Stomach adenocarcinoma(132;0.0113)|READ - Rectum adenocarcinoma(331;0.0642)		CTGAAGTCTTCCCACAACTCT	0.458000													26	77					0	0	0.004656	0	0
IRX2	153572	broad.mit.edu	37	5	2749113	2749113	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:2749113C>T	ENST00000382611.6	-	3	957	c.709G>A	c.(709-711)Gac>Aac	p.D237N	IRX2_ENST00000302057.5_Missense_Mutation_p.D237N|IRX2_ENST00000502957.1_5'UTR	NM_001134222.1	NP_001127694.1	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	237						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)	26				GBM - Glioblastoma multiforme(108;0.204)		TTCTCCCCGTCCGACTCGGCC	0.692000													13	24					0	0	0.003163	0	0
IL6R	3570	broad.mit.edu	37	1	154403046	154403046	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:154403046C>T	ENST00000368485.3	+	3	859	c.422C>T	c.(421-423)tCc>tTc	p.S141F	IL6R_ENST00000344086.4_Missense_Mutation_p.S141F	NM_000565.3	NP_000556.1	P08887	IL6RA_HUMAN	interleukin 6 receptor	141					acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity		IL6R/ATP8B2(2)	breast(2)|large_intestine(1)|ovary(3)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGCACCCCATCCCTGACGACA	0.592000													29	17					0	0	0.007291	0	0
IGSF10	285313	broad.mit.edu	37	3	151163111	151163111	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:151163111G>A	ENST00000282466.3	-	4	4657	c.4658C>T	c.(4657-4659)cCa>cTa	p.P1553L		NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	1553					cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TGTTAGTGCTGGCATGGGAGT	0.413000													46	100					0	0	0.002852	0	0
RBMY2EP	159125	broad.mit.edu	37	Y	23563366	23563366	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrY:23563366C>T	ENST00000444169.1	-	0	82					NR_001574.2																						GGGTTACCTTCTGATATGGGA	0.358000													9	0					0	0	0.006214	0	0
TLN1	7094	broad.mit.edu	37	9	35711666	35711666	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:35711666G>A	ENST00000314888.9	-	29	4158	c.3805C>T	c.(3805-3807)Cga>Tga	p.R1269*	TLN1_ENST00000540444.1_Nonsense_Mutation_p.R1269*	NM_006289.3	NP_006280.3	Q9Y490	TLN1_HUMAN	talin 1	1269					axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			NS(2)|breast(8)|central_nervous_system(2)|endometrium(10)|kidney(5)|large_intestine(9)|lung(32)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(6)	85	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			CCTGAGGCTCGAGCCAGGTCC	0.602000													47	114					0	0	0.003610	0	0
CXXC1	30827	broad.mit.edu	37	18	47813150	47813150	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:47813150A>G	ENST00000285106.6	-	2	796	c.82T>C	c.(82-84)Tac>Cac	p.Y28H	CXXC1_ENST00000589940.1_Missense_Mutation_p.Y28H|CXXC1_ENST00000412036.2_Missense_Mutation_p.Y28H|CXXC1_ENST00000587396.1_5'UTR	NM_001101654.1|NM_014593.3	NP_001095124.1|NP_055408.2	Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1	28					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						CAGATGCAGTAGATGGGCGCA	0.627000													21	40					0	0	0.002299	0	0
NUP133	55746	broad.mit.edu	37	1	229623321	229623321	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:229623321A>C	ENST00000261396.3	-	10	1325	c.1234T>G	c.(1234-1236)Ttt>Gtt	p.F412V	NUP133_ENST00000366679.1_Missense_Mutation_p.F412V|NUP133_ENST00000537506.1_Missense_Mutation_p.F396V	NM_018230.2	NP_060700.2	Q8WUM0	NU133_HUMAN	nucleoporin 133kDa	412					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			NS(1)|breast(7)|endometrium(1)|kidney(6)|large_intestine(9)|lung(20)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(4)	56	Breast(184;0.104)|Ovarian(103;0.249)	Prostate(94;0.167)				TGGTTTGAAAAGTTTGGGACC	0.348000													89	41					0	0	0.003610	0	0
DHX8	1659	broad.mit.edu	37	17	41569586	41569586	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:41569586G>A	ENST00000262415.3	+	5	501	c.429G>A	c.(427-429)gtG>gtA	p.V143V	DHX8_ENST00000540306.1_Silent_p.V143V	NM_004941.1	NP_004932.1	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	143						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		AAGTTGCTGTGGATGTCCTGA	0.473000													32	30					0	0	0.002836	0	0
MYOM1	8736	broad.mit.edu	37	18	3141961	3141961	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:3141961C>T	ENST00000356443.4	-	14	2334	c.2001G>A	c.(1999-2001)gaG>gaA	p.E667E	MYOM1_ENST00000261606.7_Silent_p.E667E|MYOM1_ENST00000400569.3_Silent_p.E667E	NM_003803.3|NM_019856.1	NP_003794.3|NP_062830.1	P52179	MYOM1_HUMAN	myomesin 1	667	Fibronectin type-III 2.					striated muscle myosin thick filament	structural constituent of muscle			NS(2)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(20)|ovary(4)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						ACATAATGCCCTCATGACCAC	0.517000													36	88					0	0	0.006230	0	0
SPINK5	11005	broad.mit.edu	37	5	147470749	147470749	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:147470749C>T	ENST00000359874.3	+	8	697	c.624C>T	c.(622-624)gcC>gcT	p.A208A	SPINK5_ENST00000256084.7_Silent_p.A208A|SPINK5_ENST00000398454.1_Silent_p.A208A|SPINK5_ENST00000476608.1_3'UTR	NM_001127698.1	NP_001121170.1	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5	208	Kazal-like 3.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(16)|ovary(4)|prostate(1)|skin(5)|stomach(8)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGAAAATGCCAAGCGAGAGG	0.348000													5	12					0	0	0.000602	0	0
RARS2	57038	broad.mit.edu	37	6	88227908	88227908	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:88227908G>A	ENST00000369536.5	-	17	1535	c.1490C>T	c.(1489-1491)tCa>tTa	p.S497L		NM_020320.3	NP_064716.2	Q5T160	SYRM_HUMAN	arginyl-tRNA synthetase 2, mitochondrial	497					arginyl-tRNA aminoacylation	mitochondrial matrix	arginine-tRNA ligase activity|ATP binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	22		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0456)		CTGAAGAATTGAAACAGACTG	0.383000													29	60					0	0	0.003271	0	0
WNK1	65125	broad.mit.edu	37	12	994852	994852	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:994852C>T	ENST00000537687.1	+	19	6305	c.5662C>T	c.(5662-5664)Ccc>Tcc	p.P1888S	WNK1_ENST00000535572.1_Missense_Mutation_p.P1381S|WNK1_ENST00000530271.2_Missense_Mutation_p.P2126S|WNK1_ENST00000340908.4_Missense_Mutation_p.P1221S|WNK1_ENST00000315939.6_Missense_Mutation_p.P1628S	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1628					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			AGCTTTGCTTCCCAACCAGCC	0.478000													24	51					0	0	0.003330	0	0
LRP5	4041	broad.mit.edu	37	11	68153959	68153959	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:68153959C>T	ENST00000294304.7	+	6	1297	c.1191C>T	c.(1189-1191)atC>atT	p.I397I		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	397	Beta-propeller 2.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						TGCGGGCCATCCGCAGGGCGT	0.637000													13	52					0	0	0.001855	0	0
RGS22	26166	broad.mit.edu	37	8	101083691	101083691	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:101083691G>A	ENST00000360863.6	-	6	694	c.500C>T	c.(499-501)cCc>cTc	p.P167L	RGS22_ENST00000523437.1_Missense_Mutation_p.P167L|RGS22_ENST00000523287.1_Intron	NM_015668.3	NP_056483.3	Q8NE09	RGS22_HUMAN	regulator of G-protein signaling 22	167					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity		RGS22/SYCP1(2)	breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(33)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	68			Epithelial(11;6.71e-08)|all cancers(13;4.19e-06)|OV - Ovarian serous cystadenocarcinoma(57;0.000469)|STAD - Stomach adenocarcinoma(118;0.169)			CACGATCCAGGGAGAAAAATT	0.378000													21	110					0	0	0.002299	0	0
OR51S1	119692	broad.mit.edu	37	11	4869588	4869588	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:4869588G>A	ENST00000322101.2	-	1	926	c.851C>T	c.(850-852)tCc>tTc	p.S284F	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	284					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATGGACATAGGATAGAAGAGT	0.448000													22	40					0	0	0.003954	0	0
BCKDHA	593	broad.mit.edu	37	19	41925149	41925149	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:41925149G>A	ENST00000269980.2	+	5	962	c.594G>A	c.(592-594)aaG>aaA	p.K198K	BCKDHA_ENST00000535632.1_3'UTR|BCKDHA_ENST00000457836.2_Silent_p.K176K|CTC-435M10.3_ENST00000540732.1_Silent_p.K232K|BCKDHA_ENST00000595085.1_Silent_p.K232K	NM_000709.3|NM_001164783.1	NP_000700.1|NP_001158255.1	P12694	ODBA_HUMAN	branched chain keto acid dehydrogenase E1, alpha polypeptide	198					branched chain family amino acid catabolic process	mitochondrial alpha-ketoglutarate dehydrogenase complex	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity|alpha-ketoacid dehydrogenase activity|carboxy-lyase activity|metal ion binding|protein binding			central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)	10						ACGGCTGCAAGGAACGCCACT	0.567000													8	9					0	0	0.003080	0	0
ZNF679	168417	broad.mit.edu	37	7	63720636	63720636	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:63720636C>T	ENST00000421025.1	+	3	346	c.77C>T	c.(76-78)tCt>tTt	p.S26F	ZNF679_ENST00000255746.4_Missense_Mutation_p.S26F	NM_001159524.1|NM_153363.2	NP_001152996.1|NP_699194.2	Q8IYX0	ZN679_HUMAN	zinc finger protein 679	26	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(3)|lung(11)|skin(1)|stomach(1)	18						ATAGAATTCTCTCTGGAGGAG	0.418000													12	29					0	0	0.000978	0	0
EIF3B	8662	broad.mit.edu	37	7	2412393	2412393	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2412393C>T	ENST00000360876.4	+	12	1829	c.1773C>T	c.(1771-1773)ttC>ttT	p.F591F	EIF3B_ENST00000397011.2_Silent_p.F591F	NM_001037283.1	NP_001032360.1	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3, subunit B	591					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity			breast(2)|endometrium(4)|kidney(2)|large_intestine(3)|lung(11)|ovary(1)|skin(1)	24		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CTGTGTCTTTCTACCACGTCA	0.473000													6	134					0	0	0.001168	0	0
PRF1	5551	broad.mit.edu	37	10	72358711	72358711	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:72358711C>T	ENST00000441259.1	-	3	926	c.766G>A	c.(766-768)Gac>Aac	p.D256N	PRF1_ENST00000373209.2_Missense_Mutation_p.D256N	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	256	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						GTCAGGCAGTCCTCCACCTCG	0.622000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				10	22					0	0	0.000978	0	0
EVA1C	59271	broad.mit.edu	37	21	33887342	33887342	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:33887342C>T	ENST00000300255.2	+	8	1641	c.1168C>T	c.(1168-1170)Ctg>Ttg	p.L390L	EVA1C_ENST00000382699.3_Silent_p.L387L|EVA1C_ENST00000401402.3_Silent_p.L342L|EVA1C_ENST00000485488.1_3'UTR	NM_058187.3	NP_478067.2			eva-1 homolog C (C. elegans)																		CCCAGGGGAACTGTCGGGGTT	0.532000													26	45					0	0	0.003954	0	0
CELF4	56853	broad.mit.edu	37	18	34846537	34846537	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:34846537G>A	ENST00000420428.2	-	9	1519	c.1124C>T	c.(1123-1125)cCc>cTc	p.P375L	CELF4_ENST00000412753.1_Missense_Mutation_p.P374L|CELF4_ENST00000601019.1_Missense_Mutation_p.P373L|CELF4_ENST00000361795.5_Missense_Mutation_p.P373L|CELF4_ENST00000334919.5_Missense_Mutation_p.P365L|CELF4_ENST00000591287.1_Missense_Mutation_p.P374L|CELF4_ENST00000591282.1_Missense_Mutation_p.P375L|CELF4_ENST00000603232.1_Missense_Mutation_p.P374L|CELF4_ENST00000588597.1_Missense_Mutation_p.P364L	NM_020180.3	NP_064565.1	Q9BZC1	CELF4_HUMAN	CUGBP, Elav-like family member 4	375					embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(8)|lung(18)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	44						CTGCTGCAGGGGGTCCGCGGC	0.647000													3	2					0	0	0.000248	0	0
BCMO1	53630	broad.mit.edu	37	16	81293407	81293407	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:81293407C>T	ENST00000258168.2	+	3	781	c.320C>T	c.(319-321)tCc>tTc	p.S107F	BCMO1_ENST00000564552.1_Missense_Mutation_p.S107F|BCMO1_ENST00000425577.2_Intron	NM_017429.2	NP_059125.2	Q9HAY6	BCDO1_HUMAN	beta-carotene 15,15'-monooxygenase 1	107					retinoid metabolic process|steroid metabolic process	cytosol	beta-carotene 15,15'-monooxygenase activity|metal ion binding|monooxygenase activity			breast(2)|endometrium(1)|large_intestine(4)|lung(9)|prostate(3)|skin(3)|stomach(1)	23						AACATATTTTCCAAGTAACTG	0.408000													25	64					0	0	0.004656	0	0
PLEKHG4	25894	broad.mit.edu	37	16	67322240	67322240	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:67322240C>T	ENST00000360461.5	+	19	5926	c.3391C>T	c.(3391-3393)Ccc>Tcc	p.P1131S	PLEKHG4_ENST00000450733.1_Missense_Mutation_p.P1050S|PLEKHG4_ENST00000379344.3_Missense_Mutation_p.P1131S|PLEKHG4_ENST00000427155.2_Missense_Mutation_p.P1131S	NM_001129727.1|NM_015432.3	NP_001123199.1|NP_056247.1	Q58EX7	PKHG4_HUMAN	pleckstrin homology domain containing, family G (with RhoGef domain) member 4	1131					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)|Kidney(780;0.119)		TCCCCTGTATCCCAGCTTCCC	0.627000													25	56					0	0	0.003330	0	0
MOGAT3	346606	broad.mit.edu	37	7	100839346	100839346	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:100839346G>A	ENST00000223114.4	-	7	1073	c.907C>T	c.(907-909)Ccc>Tcc	p.P303S	MOGAT3_ENST00000379423.3_Missense_Mutation_p.P235L|MOGAT3_ENST00000440203.2_Silent_p.T331T	NM_178176.2	NP_835470.1	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	303					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(10)|ovary(3)	22	Lung NSC(181;0.168)|all_lung(186;0.215)					TCCTCGGTGGGGTGGAGGCGC	0.667000													7	5					0	0	0.001984	0	0
AHNAK	79026	broad.mit.edu	37	11	62295771	62295771	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:62295771G>A	ENST00000378024.4	-	5	6392	c.6118C>T	c.(6118-6120)Cat>Tat	p.H2040Y	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	2040					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				TCTGGGCCATGAACATCCACA	0.498000													111	171					0	0	0.003610	0	0
LRBA	987	broad.mit.edu	37	4	151749500	151749500	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:151749500G>A	ENST00000535741.1	-	30	5476	c.5003C>T	c.(5002-5004)cCg>cTg	p.P1668L	LRBA_ENST00000510413.1_Missense_Mutation_p.P1668L|LRBA_ENST00000507224.1_Missense_Mutation_p.P1668L|LRBA_ENST00000357115.3_Missense_Mutation_p.P1668L			P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and anchor containing	1668						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			breast(6)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(20)|lung(32)|ovary(4)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	91	all_hematologic(180;0.151)					TGAAACTGACGGTGTAGCCTT	0.433000													21	29					0	0	0.001882	0	0
RGPD4	285190	broad.mit.edu	37	2	108488640	108488640	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:108488640C>T	ENST00000408999.3	+	20	4257	c.4180C>T	c.(4180-4182)Cgt>Tgt	p.R1394C	RGPD4_ENST00000354986.4_Missense_Mutation_p.R1394C	NM_182588.2	NP_872394.2	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1394	RanBD1 2.				intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						TAAGCAAGTTCGTATAGTGAT	0.358000													99	148					0	0	0.003610	0	0
OR5M11	219487	broad.mit.edu	37	11	56310479	56310479	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:56310479G>A	ENST00000528616.2	-	1	278	c.255C>T	c.(253-255)atC>atT	p.I85I		NM_001005245.1	NP_001005245.1	Q96RB7	OR5MB_HUMAN	olfactory receptor, family 5, subfamily M, member 11	85					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)	18						TCTCAGATACGATATTAGTCG	0.448000													28	359					0	0	0.005443	0	0
VSTM1	284415	broad.mit.edu	37	19	54545034	54545034	+	Splice_Site	SNP	G	G	A	rs148134957	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54545034G>A	ENST00000338372.2	-	8	765	c.591_splice	c.e8+1	p.S197_splice	VSTM1_ENST00000425006.2_3'UTR|VSTM1_ENST00000376626.1_Splice_Site_p.S166_splice|VSTM1_ENST00000366170.2_Splice_Site_p.S109_splice	NM_198481.3	NP_940883.2	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	197						integral to membrane				breast(1)|large_intestine(3)|lung(11)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		AGGACTCACCGAGAGAGATAC	0.458000													7	26					0	0	0.003080	0	0
TRAV27	28655	broad.mit.edu	37	14	22616359	22616359	+	RNA	SNP	G	G	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:22616359G>C	ENST00000390457.2	+	0	197																											CATCCAAGAGGGAGAAAATCT	0.507000													13	13					0	0	0.001855	0	0
NLRP12	91662	broad.mit.edu	37	19	54327292	54327292	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54327292C>T	ENST00000324134.6	-	1	305	c.137G>A	c.(136-138)gGa>gAa	p.G46E	NLRP12_ENST00000535162.1_Missense_Mutation_p.G46E|NLRP12_ENST00000351894.4_Missense_Mutation_p.G46E|NLRP12_ENST00000391772.1_Missense_Mutation_p.G46E|NLRP12_ENST00000391775.3_Missense_Mutation_p.G46E|NLRP12_ENST00000345770.5_Missense_Mutation_p.G46E|NLRP12_ENST00000354278.3_Missense_Mutation_p.G46E|NLRP12_ENST00000391773.1_Missense_Mutation_p.G46E	NM_001277126.1|NM_144687.2	NP_001264055.1|NP_653288.1	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12	46	DAPIN.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			NS(1)|breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(36)|ovary(5)|pancreas(2)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	80	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CTCCATGCTTCCCCAGGGGAT	0.592000													17	79					0	0	0.004990	0	0
HRNR	388697	broad.mit.edu	37	1	152188255	152188255	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:152188255G>A	ENST00000368801.2	-	3	5925	c.5850C>T	c.(5848-5850)agC>agT	p.S1950S	FLG-AS1_ENST00000593011.1_RNA|FLG-AS1_ENST00000420707.1_RNA	NM_001009931.1	NP_001009931.1	Q86YZ3	HORN_HUMAN	hornerin	1950					keratinization		calcium ion binding|protein binding			autonomic_ganglia(1)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(22)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(19)|liver(1)|lung(84)|ovary(5)|prostate(6)|skin(12)|stomach(9)|upper_aerodigestive_tract(5)|urinary_tract(6)	192	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTCGGCCACGGCTAGGGCTAG	0.607000													99	393					0	0	0.003610	0	0
KIAA1109	84162	broad.mit.edu	37	4	123118412	123118412	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:123118412T>A	ENST00000264501.4	+	13	1644	c.1271T>A	c.(1270-1272)aTg>aAg	p.M424K	KIAA1109_ENST00000455637.1_Missense_Mutation_p.M424K|KIAA1109_ENST00000495260.1_3'UTR|KIAA1109_ENST00000388738.3_Missense_Mutation_p.M424K			Q2LD37	K1109_HUMAN	KIAA1109	424					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						AATATTCCAATGACAGTTGAA	0.244000													20	21					0	0	0.003330	0	0
TTN	7273	broad.mit.edu	37	2	179595861	179595861	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:179595861A>C	ENST00000589042.1	-	60	17755	c.17531T>G	c.(17530-17532)gTt>gGt	p.V5844G	TTN_ENST00000359218.5_Intron|TTN_ENST00000342175.6_Intron|TTN_ENST00000591111.1_Missense_Mutation_p.V5527G|TTN_ENST00000460472.2_Intron|TTN_ENST00000342992.6_Missense_Mutation_p.V4600G|TTN-AS1_ENST00000585451.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	5527	Ig-like 39.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGAAAATTTAACCTGCAAAGT	0.438000													52	77					0	0	0.003610	0	0
OR10H4	126541	broad.mit.edu	37	19	16060708	16060708	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:16060708G>A	ENST00000322107.1	+	1	891	c.891G>A	c.(889-891)aaG>aaA	p.K297K		NM_001004465.1	NP_001004465.1	Q8NGA5	O10H4_HUMAN	olfactory receptor, family 10, subfamily H, member 4	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|urinary_tract(1)	17						TAAGGAACAAGGAGCTGAAGA	0.433000													49	52					0	0	0.003610	0	0
MX2	4600	broad.mit.edu	37	21	42778893	42778893	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:42778893G>A	ENST00000330714.3	+	13	2057	c.1873G>A	c.(1873-1875)Gaa>Aaa	p.E625K		NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)	625	GED.				response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				CTCCTTTACTGAAATAGGCAT	0.488000													17	23					0	0	0.007413	0	0
DENND1C	79958	broad.mit.edu	37	19	6468102	6468102	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:6468102C>T	ENST00000381480.2	-	23	1931	c.1819G>A	c.(1819-1821)Gat>Aat	p.D607N	DENND1C_ENST00000543576.1_Missense_Mutation_p.D563N	NM_024898.2	NP_079174.2	Q8IV53	DEN1C_HUMAN	DENN/MADD domain containing 1C	607						clathrin-coated vesicle|cytosol	guanyl-nucleotide exchange factor activity			endometrium(3)|kidney(3)|large_intestine(1)|lung(3)	10						AGTTTCTTATCGTCTGGTTGC	0.542000													15	22					0	0	0.006122	0	0
CCR9	10803	broad.mit.edu	37	3	45943326	45943326	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:45943326G>A	ENST00000357632.2	+	3	1226	c.1046G>A	c.(1045-1047)aGa>aAa	p.R349K	CCR9_ENST00000355983.2_Missense_Mutation_p.R337K|LZTFL1_ENST00000536047.1_Intron|CCR9_ENST00000422395.1_3'UTR|CCR9_ENST00000395963.2_Missense_Mutation_p.R337K|LZTFL1_ENST00000539217.1_Intron	NM_001256369.1|NM_031200.2	NP_001243298.1|NP_112477.1	P51686	CCR9_HUMAN	chemokine (C-C motif) receptor 9	349					cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane				breast(1)|endometrium(4)|large_intestine(8)|lung(2)|ovary(2)|prostate(2)|skin(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.00118)|KIRC - Kidney renal clear cell carcinoma(197;0.0182)|Kidney(197;0.0214)		TTTACAAGGAGAGAGGGAAGC	0.512000													17	44					0	0	0.007413	0	0
ARID1A	8289	broad.mit.edu	37	1	27100165	27100165	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:27100165C>T	ENST00000324856.7	+	16	4332	c.3961C>T	c.(3961-3963)Cct>Tct	p.P1321S	ARID1A_ENST00000540690.1_5'UTR|ARID1A_ENST00000457599.2_Missense_Mutation_p.P1321S|ARID1A_ENST00000374152.2_Missense_Mutation_p.P938S	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	1321					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GATGTATTCTCCTAGCCGCTA	0.607000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								22	43					0	0	0.002780	0	0
SYNJ1	8867	broad.mit.edu	37	21	34011387	34011387	+	Missense_Mutation	SNP	G	G	T	rs149288077	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:34011387G>T	ENST00000382499.2	-	31	3862	c.3863C>A	c.(3862-3864)cCg>cAg	p.P1288Q	SYNJ1_ENST00000382491.3_Missense_Mutation_p.P1202Q|SYNJ1_ENST00000357345.3_Missense_Mutation_p.P1233Q|SYNJ1_ENST00000322229.7_Missense_Mutation_p.P1249Q|SYNJ1_ENST00000433931.2_Missense_Mutation_p.P1288Q	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	1249	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						AGAAGACTGCGGAGGAAAAGC	0.498000													27	81					6.07407e-21	1.03874e-20	0.007291	1	0
TTC39C	125488	broad.mit.edu	37	18	21703897	21703897	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:21703897C>T	ENST00000540918.2	+	4	615	c.365C>T	c.(364-366)tCg>tTg	p.S122L	TTC39C_ENST00000317571.3_Missense_Mutation_p.S429L|TTC39C_ENST00000304621.6_Missense_Mutation_p.S368L			Q8N584	TT39C_HUMAN	tetratricopeptide repeat domain 39C	429							binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|prostate(1)|skin(1)	19						GAACAGTTCTCGGTGAAAAAG	0.398000													8	7					0	0	0.004482	0	0
ABCA13	154664	broad.mit.edu	37	7	48317811	48317811	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:48317811G>A	ENST00000435803.1	+	18	7044	c.7020G>A	c.(7018-7020)atG>atA	p.M2340I		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2340					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						ATCACCTAATGAAAAGTTCAT	0.303000													10	16					0	0	0.000673	0	0
EEFSEC	60678	broad.mit.edu	37	3	128126937	128126937	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:128126937G>A	ENST00000483457.1	+	5	1311	c.1304G>A	c.(1303-1305)aGa>aAa	p.R435K	EEFSEC_ENST00000254730.6_Silent_p.K542K			P57772	SELB_HUMAN	eukaryotic elongation factor, selenocysteine-tRNA-specific	0			A -> V (in dbSNP:rs34326479).			cytoplasm|nucleus	GTP binding|GTPase activity|translation elongation factor activity			NS(1)|endometrium(3)|kidney(4)|large_intestine(6)|lung(10)|ovary(1)	25						AGTCCAAGAAGATCCTGACAC	0.692000													7	14					0	0	0.003080	0	0
TRPS1	7227	broad.mit.edu	37	8	116426751	116426751	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:116426751T>A	ENST00000395715.3	-	7	3962	c.3385A>T	c.(3385-3387)Aaa>Taa	p.K1129*	TRPS1_ENST00000520276.1_Nonsense_Mutation_p.K1120*|TRPS1_ENST00000220888.5_Nonsense_Mutation_p.K1116*|TRPS1_ENST00000519076.1_Nonsense_Mutation_p.K870*	NM_014112.2	NP_054831.2	Q9UHF7	TRPS1_HUMAN	trichorhinophalangeal syndrome I	1116	Mediates interaction with RNF4 (By similarity).				negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(25)|lung(58)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	111	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			AGCTTATATTTACTCCAGAAC	0.473000									Langer-Giedion syndrome				16	52					0	0	0.003163	0	0
RNF220	55182	broad.mit.edu	37	1	44878025	44878025	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:44878025C>T	ENST00000355387.2	+	2	706	c.256C>T	c.(256-258)Cgt>Tgt	p.R86C	RNF220_ENST00000361799.2_Missense_Mutation_p.R86C|RNF220_ENST00000372247.2_Missense_Mutation_p.R86C			Q5VTB9	RN220_HUMAN	ring finger protein 220	86					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			endometrium(6)|kidney(1)|large_intestine(3)|lung(13)|ovary(2)|skin(2)|urinary_tract(2)	29						TTTTGCCAATCGTGATTTCCC	0.507000													76	189					0	0	0.003610	0	0
KMT2D	8085	broad.mit.edu	37	12	49435896	49435896	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:49435896G>A	ENST00000301067.7	-	28	6084	c.6085C>T	c.(6085-6087)Cct>Tct	p.P2029S		NM_003482.3	NP_003473.3			lysine (K)-specific methyltransferase 2D																		TTGAGATTAGGAAAATTAATG	0.542000													4	27					0	0	0.001168	0	0
EGR1	1958	broad.mit.edu	37	5	137803293	137803293	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:137803293C>T	ENST00000239938.4	+	2	1427	c.1155C>T	c.(1153-1155)acC>acT	p.T385T		NM_001964.2	NP_001955.1	P18146	EGR1_HUMAN	early growth response 1	385					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			ACCTCACCACCCACATCCGCA	0.602000													10	60					0	0	0.000673	0	0
PCDHGA6	56109	broad.mit.edu	37	5	140755006	140755006	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140755006C>T	ENST00000517434.1	+	1	1356	c.1356C>T	c.(1354-1356)ttC>ttT	p.F452F	PCDHGA5_ENST00000518069.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGB2_ENST00000522605.1_Intron	NM_018919.2|NM_032086.1	NP_061742.1|NP_114475.1														breast(1)|large_intestine(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCCACCTTCCCCCATTCAT	0.527000													91	107					0	0	0.003610	0	0
MYO18B	84700	broad.mit.edu	37	22	26224752	26224752	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:26224752C>T	ENST00000335473.7	+	15	3046	c.2796C>T	c.(2794-2796)tcC>tcT	p.S932S	MYO18B_ENST00000407587.2_Silent_p.S932S|MYO18B_ENST00000536101.1_Silent_p.S932S	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	932	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GATCCTTTTCCTCCCACCATC	0.567000													17	18					0	0	0.007413	0	0
COL14A1	7373	broad.mit.edu	37	8	121239556	121239556	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:121239556G>A	ENST00000297848.3	+	17	2372	c.2102G>A	c.(2101-2103)aGc>aAc	p.S701N	COL14A1_ENST00000537875.1_3'UTR|COL14A1_ENST00000247781.3_Missense_Mutation_p.S606N|COL14A1_ENST00000309791.4_Missense_Mutation_p.S701N|COL14A1_ENST00000432943.2_3'UTR	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	701	Fibronectin type-III 5.				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			GATGATGGAAGCGAGAGTGAG	0.512000													23	148					0	0	0.004656	0	0
SCN1A	6323	broad.mit.edu	37	2	166893031	166893031	+	Missense_Mutation	SNP	G	G	A	rs121918625		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:166893031G>A	ENST00000423058.2	-	16	2973	c.2956C>T	c.(2956-2958)Ctc>Ttc	p.L986F	AC010127.3_ENST00000595268.1_RNA|SCN1A_ENST00000409050.1_Missense_Mutation_p.L958F|SCN1A_ENST00000375405.3_Missense_Mutation_p.L975F|SCN1A_ENST00000303395.4_Missense_Mutation_p.L986F|AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000599041.1_RNA	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	986			L -> F (in SMEI; complete loss of function; dbSNP:rs121918625).			voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GCCAGAAAGAGATTCAGGACC	0.353000													14	13					0	0	0.001855	0	0
DENND1A	57706	broad.mit.edu	37	9	126144641	126144641	+	Silent	SNP	G	G	A	rs149511328		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:126144641G>A	ENST00000373624.2	-	22	2301	c.2100C>T	c.(2098-2100)ccC>ccT	p.P700P	DENND1A_ENST00000542603.1_Silent_p.P485P|DENND1A_ENST00000394219.3_Silent_p.P711P|DENND1A_ENST00000473039.1_5'UTR	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	700	Pro-rich.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						CTTGGGGCCGGGGGATGGTGA	0.697000													11	6					0	0	0.000978	0	0
POU5F1	5460	broad.mit.edu	37	6	31133377	31133377	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31133377C>T	ENST00000513407.1	-	1	1570	c.40G>A	c.(40-42)Gaa>Aaa	p.E14K	POU5F1_ENST00000259915.8_Missense_Mutation_p.E210K|POU5F1_ENST00000512818.1_Missense_Mutation_p.E14K|POU5F1_ENST00000471529.2_Missense_Mutation_p.E14K|POU5F1_ENST00000606567.1_Missense_Mutation_p.E40K|POU5F1_ENST00000441888.3_Missense_Mutation_p.E14K			Q01860	PO5F1_HUMAN	POU class 5 homeobox 1	210					anatomical structure morphogenesis|blastocyst development|BMP signaling pathway involved in heart induction|cardiac cell fate determination|cell fate commitment involved in formation of primary germ layers|mRNA transcription from RNA polymerase II promoter|negative regulation of gene silencing by miRNA|positive regulation of catenin import into nucleus|positive regulation of SMAD protein import into nucleus|positive regulation of transcription from RNA polymerase II promoter|regulation of asymmetric cell division|regulation of heart induction by regulation of canonical Wnt receptor signaling pathway|regulation of methylation-dependent chromatin silencing|response to wounding|somatic stem cell maintenance	cytosol|nucleoplasm|transcription factor complex	miRNA binding|sequence-specific DNA binding|sequence-specific DNA binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|ubiquitin protein ligase binding		EWSR1/POU5F1(10)	breast(1)|large_intestine(2)|lung(3)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	13						TTGTCAGCTTCCTCCACCCAC	0.527000			T	EWSR1	sarcoma								10	99					0	0	0.006214	0	0
CCR1	1230	broad.mit.edu	37	3	46245783	46245783	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:46245783C>T	ENST00000296140.3	-	2	147	c.22G>A	c.(22-24)Gag>Aag	p.E8K	CCR3_ENST00000357422.2_Intron	NM_001295.2	NP_001286.1	P32246	CCR1_HUMAN	chemokine (C-C motif) receptor 1	8					cell adhesion|cell-cell signaling|cytokine-mediated signaling pathway|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	integral to plasma membrane	C-C chemokine receptor activity			autonomic_ganglia(1)|large_intestine(6)|lung(6)|pancreas(1)|skin(3)	17				BRCA - Breast invasive adenocarcinoma(193;0.00113)|KIRC - Kidney renal clear cell carcinoma(197;0.0172)|Kidney(197;0.0203)		TCATAGTCCTCTGTGGTGTTT	0.498000													8	20					0	0	0.004482	0	0
PRTG	283659	broad.mit.edu	37	15	55921201	55921201	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:55921201C>T	ENST00000389286.4	-	16	2672	c.2623_splice	c.e16-1	p.G875_splice		NM_173814.4	NP_776175.2	Q2VWP7	PRTG_HUMAN	protogenin	875	Fibronectin type-III 5.				multicellular organismal development	integral to membrane				breast(1)|endometrium(6)|kidney(4)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	41				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		TGGTTATTGCCCCTAGAAATA	0.318000													10	16					0	0	0.000673	0	0
PDCD1LG2	80380	broad.mit.edu	37	9	5549574	5549574	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:5549574G>A	ENST00000397747.3	+	4	849	c.601G>A	c.(601-603)Gaa>Aaa	p.E201K	PDCD1LG2_ENST00000397745.2_Intron	NM_025239.3	NP_079515.2	Q9BQ51	PD1L2_HUMAN	programmed cell death 1 ligand 2	201	Ig-like C2-type.				immune response|T cell costimulation	endomembrane system|extracellular region|integral to membrane|plasma membrane	receptor activity			large_intestine(2)|lung(4)|prostate(2)	8	all_hematologic(13;0.158)	Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000767)|Lung(218;0.112)		TCACGTGAGGGAACTTACTTT	0.517000													12	46					0	0	0.001368	0	0
CLPS	1208	broad.mit.edu	37	6	35763630	35763630	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:35763630C>T	ENST00000259938.2	-	2	107	c.84_splice	c.e2-1	p.E29_splice		NM_001832.3	NP_001823.1	P04118	COL_HUMAN	colipase, pancreatic	29					lipid catabolic process|lipid digestion|retinoid metabolic process|steroid metabolic process	extracellular region				large_intestine(2)|lung(2)|prostate(1)	5						TCACCGTTCTCCTGCCAGGAG	0.597000													29	149					0	0	0.002445	0	0
EXOC3	11336	broad.mit.edu	37	5	458137	458137	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:458137C>T	ENST00000512944.1	+	6	1476	c.1287C>T	c.(1285-1287)ttC>ttT	p.F429F	EXOC3_ENST00000315013.5_Silent_p.F429F	NM_007277.4	NP_009208.2	O60645	EXOC3_HUMAN	exocyst complex component 3	440					exocytosis|protein transport					breast(2)|cervix(1)|endometrium(4)|large_intestine(1)|lung(13)|ovary(1)|urinary_tract(1)	23		Ovarian(839;0.0563)	Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CCATTGTCTTCCAGGTACCAC	0.537000													7	13					0	0	0.004482	0	0
CRYM	1428	broad.mit.edu	37	16	21272580	21272580	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:21272580G>A	ENST00000219599.3	-	9	1140	c.875C>T	c.(874-876)tCt>tTt	p.S292F	CRYM_ENST00000396023.2_Missense_Mutation_p.S292F|CRYM_ENST00000415987.2_Missense_Mutation_p.S250F|CRYM_ENST00000543948.1_Missense_Mutation_p.S292F	NM_001888.3	NP_001879.1	Q14894	CRYM_HUMAN	crystallin, mu	292					negative regulation of transcription from RNA polymerase II promoter|sensory perception of sound|thyroid hormone transport	cytoplasm|nucleus|plasma membrane	NADP binding|protein homodimerization activity|thyroid hormone binding|transcription corepressor activity			large_intestine(1)|lung(3)	4				GBM - Glioblastoma multiforme(48;0.0573)	Levothyroxine(DB00451)	CTTACCCAAAGACTTGAACAC	0.512000													8	10					0	0	0.003080	0	0
KIAA1522	57648	broad.mit.edu	37	1	33236519	33236519	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:33236519C>T	ENST00000401073.2	+	6	1809	c.1739C>T	c.(1738-1740)cCc>cTc	p.P580L	KIAA1522_ENST00000373480.1_Missense_Mutation_p.P521L|KIAA1522_ENST00000294521.3_Intron|KIAA1522_ENST00000373481.3_Missense_Mutation_p.P532L	NM_020888.2	NP_065939.2	Q9P206	K1522_HUMAN	KIAA1522	521	Pro-rich.									breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(2)|lung(5)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				ACACTTTCGCCCTCCAGTGGA	0.667000													5	9					0	0	0.000602	0	0
ALDH7A1	501	broad.mit.edu	37	5	125919695	125919695	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:125919695G>A	ENST00000409134.3	-	4	541	c.322C>T	c.(322-324)Cca>Tca	p.P108S	ALDH7A1_ENST00000447989.2_Missense_Mutation_p.P135S|ALDH7A1_ENST00000553117.1_Missense_Mutation_p.P108S|ALDH7A1_ENST00000413020.1_5'UTR	NM_001182.4|NM_001201377.1	NP_001173.2|NP_001188306.1	P49419	AL7A1_HUMAN	aldehyde dehydrogenase 7 family, member A1	108					cellular aldehyde metabolic process|lysine catabolic process|sensory perception of sound	cytosol|mitochondrial matrix|nucleus	aldehyde dehydrogenase (NAD) activity|betaine-aldehyde dehydrogenase activity|L-aminoadipate-semialdehyde dehydrogenase activity			endometrium(1)|kidney(4)|large_intestine(4)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)	16		all_cancers(142;0.24)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.0584)|Kidney(363;0.0934)	Epithelial(69;0.0417)|OV - Ovarian serous cystadenocarcinoma(64;0.068)|all cancers(49;0.109)	NADH(DB00157)|Pyridoxine(DB00165)	CCTCGTTTTGGAGCAGGAATC	0.348000													29	99					0	0	0.002096	0	0
DPY19L4	286148	broad.mit.edu	37	8	95777444	95777444	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:95777444C>T	ENST00000414645.2	+	9	1003	c.904C>T	c.(904-906)Ctc>Ttc	p.L302F		NM_181787.2	NP_861452.2	Q7Z388	D19L4_HUMAN	dpy-19-like 4 (C. elegans)	302						integral to membrane				breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(2)|lung(6)|ovary(2)|prostate(2)	21	Breast(36;3.85e-06)					CATATTTTCCCTCTTTCTGGG	0.294000													148	628					0	0	0.003610	0	0
ITPR1	3708	broad.mit.edu	37	3	4735338	4735338	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:4735338G>A	ENST00000354582.6	+	33	4544	c.4194G>A	c.(4192-4194)aaG>aaA	p.K1398K	ITPR1_ENST00000302640.8_Silent_p.K1383K|ITPR1_ENST00000456211.2_Silent_p.K1374K|ITPR1_ENST00000443694.2_Silent_p.K1383K|ITPR1_ENST00000423119.2_Silent_p.K1389K|ITPR1_ENST00000544951.1_Intron|ITPR1_ENST00000357086.4_Silent_p.K1389K			Q14643	ITPR1_HUMAN	inositol 1,4,5-trisphosphate receptor, type 1	1398					activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			NS(1)|autonomic_ganglia(1)|breast(10)|endometrium(15)|kidney(6)|large_intestine(27)|liver(1)|lung(27)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(2)	106				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CGGAGGGTAAGAATGTCTACA	0.572000													19	32					0	0	0.006122	0	0
HLF	3131	broad.mit.edu	37	17	53342916	53342916	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:53342916C>T	ENST00000226067.5	+	1	544	c.71C>T	c.(70-72)tCc>tTc	p.S24F		NM_002126.4	NP_002117.1	Q16534	HLF_HUMAN	hepatic leukemia factor	24					multicellular organismal development|rhythmic process|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(2)	3						GTGCTCAGGTCCCTGCTGGAG	0.637000			T	TCF3	ALL								8	42					0	0	0.001368	0	0
APOB	338	broad.mit.edu	37	2	21224983	21224983	+	Silent	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:21224983T>G	ENST00000233242.1	-	29	13438	c.13311A>C	c.(13309-13311)tcA>tcC	p.S4437S		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	4437					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CAACTTGACTTGAGAGTTGGG	0.388000													218	462					0	0	0.003610	0	0
RLTPR	146206	broad.mit.edu	37	16	67685394	67685394	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:67685394G>A	ENST00000334583.6	+	24	2732	c.2404G>A	c.(2404-2406)Gag>Aag	p.E802K	RLTPR_ENST00000545661.1_Missense_Mutation_p.E766K	NM_001013838.1	NP_001013860.1	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing	802										breast(1)|cervix(1)|endometrium(4)|kidney(1)|lung(9)|urinary_tract(2)	18		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		ACAGGTGGGCGAGGTCTGCCG	0.562000													4	8					0	0	0.000248	0	0
CEP112	201134	broad.mit.edu	37	17	63898358	63898358	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:63898358C>T	ENST00000392769.2	-	20	2293	c.2075G>A	c.(2074-2076)cGg>cAg	p.R692Q	CEP112_ENST00000541355.1_Missense_Mutation_p.R327Q|CEP112_ENST00000537949.1_Missense_Mutation_p.R650Q|CEP112_ENST00000535342.2_Missense_Mutation_p.R692Q	NM_145036.3	NP_659473.2	Q8N8E3	CE112_HUMAN	centrosomal protein 112kDa	692						centrosome				NS(1)|breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(8)|lung(11)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	28						TTCAATTTCCCGTTCATGGTC	0.443000													20	56					0	0	0.001523	0	0
LRRC31	79782	broad.mit.edu	37	3	169557848	169557848	+	Silent	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:169557848A>T	ENST00000316428.5	-	9	1638	c.1581T>A	c.(1579-1581)gcT>gcA	p.A527A	LRRC31_ENST00000264676.5_Silent_p.A471A|LRRC31_ENST00000523069.1_3'UTR	NM_001277127.1|NM_024727.2	NP_001264056.1|NP_079003.2	Q6UY01	LRC31_HUMAN	leucine rich repeat containing 31	527										cervix(3)|endometrium(3)|large_intestine(8)|lung(9)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	31	all_cancers(22;2.76e-22)|all_epithelial(15;4.73e-27)|all_lung(20;9.24e-17)|Lung NSC(18;3.85e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00943)			CCTCCTGTGAAGCTGGGAGAA	0.398000													8	38					0	0	0.003080	0	0
OR6K3	391114	broad.mit.edu	37	1	158687328	158687328	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:158687328G>A	ENST00000368146.1	-	1	625	c.626C>T	c.(625-627)tCc>tTc	p.S209F	OR6K3_ENST00000368145.1_Missense_Mutation_p.S193F			Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K, member 3	209					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)	41	all_hematologic(112;0.0378)					CAGAATCATGGACGTGTCTGT	0.453000													45	133					0	0	0.003610	0	0
EP400	57634	broad.mit.edu	37	12	132471241	132471241	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:132471241C>T	ENST00000333577.4	+	7	2329	c.2220C>T	c.(2218-2220)tcC>tcT	p.S740S	EP400_ENST00000330386.6_Silent_p.S704S|EP400_ENST00000389561.2_Silent_p.S704S|EP400_ENST00000389562.2_Silent_p.S703S|EP400_ENST00000332482.4_Silent_p.S667S			Q96L91	EP400_HUMAN	E1A binding protein p400	740					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CAGTCACTTCCCGGACCCCAG	0.592000													38	82					0	0	0.006230	0	0
TNFSF12-TNFSF13	407977	broad.mit.edu	37	17	7460146	7460146	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:7460146G>A	ENST00000293826.4	+	6	480	c.425G>A	c.(424-426)aGc>aAc	p.S142N	TNFSF12_ENST00000293825.6_Missense_Mutation_p.S142N|TNFSF12_ENST00000557233.1_Missense_Mutation_p.S142N|TNFSF12_ENST00000462811.1_3'UTR	NM_172089.3	NP_742086.1	Q8IZK7	Q8IZK7_HUMAN		142					immune response	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)|large_intestine(2)	3		Prostate(122;0.157)				AACAGCTCCAGCCCTCTGCGC	0.567000													20	16					0	0	0.007413	0	0
SVEP1	79987	broad.mit.edu	37	9	113205957	113205957	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:113205957G>C	ENST00000401783.2	-	27	4843	c.4507C>G	c.(4507-4509)Ccc>Gcc	p.P1503A	SVEP1_ENST00000467821.1_5'UTR|SVEP1_ENST00000374469.1_Missense_Mutation_p.P1480A|SVEP1_ENST00000302728.8_Missense_Mutation_p.P1503A	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	1503	Pentaxin.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						TTCACCGAGGGACAGTTTGTT	0.433000													9	15					0	0	0.001368	0	0
OR2B2	81697	broad.mit.edu	37	6	27879100	27879100	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:27879100T>A	ENST00000303324.2	-	1	1074	c.998A>T	c.(997-999)aAc>aTc	p.N333I		NM_033057.2	NP_149046.2	Q9GZK3	OR2B2_HUMAN	olfactory receptor, family 2, subfamily B, member 2	333					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(4)|large_intestine(5)|lung(10)|prostate(1)|urinary_tract(1)	22						TGCGGAGAAGTTAGTAAGGTA	0.318000													17	99					0	0	0.007413	0	0
DNAH10	196385	broad.mit.edu	37	12	124298047	124298047	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:124298047G>A	ENST00000409039.3	+	19	3152	c.3127G>A	c.(3127-3129)Gat>Aat	p.D1043N		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1043	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCTAATTAAGGATGAGCATTG	0.438000													13	43					0	0	0.001368	0	0
DNAJC5B	85479	broad.mit.edu	37	8	66963868	66963868	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:66963868G>A	ENST00000276570.5	+	3	373	c.86G>A	c.(85-87)gGa>gAa	p.G29E	DNAJC5B_ENST00000519330.1_3'UTR	NM_033105.4	NP_149096.2	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5 beta	29	J.				protein folding	membrane	heat shock protein binding|unfolded protein binding			endometrium(3)|large_intestine(6)|liver(1)|lung(6)|prostate(1)|skin(3)	20		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			CTGCATAAGGGAGCATCAAAT	0.408000													20	130					0	0	0.001523	0	0
FNDC7	163479	broad.mit.edu	37	1	109270433	109270433	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:109270433C>T	ENST00000370017.3	+	7	1392	c.1115C>T	c.(1114-1116)cCc>cTc	p.P372L	FNDC7_ENST00000271311.2_Missense_Mutation_p.P373L	NM_001144937.1	NP_001138409.1	Q5VTL7	FNDC7_HUMAN	fibronectin type III domain containing 7	373						extracellular region				breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|ovary(1)|skin(4)|stomach(1)|urinary_tract(1)	20		all_lung(203;0.00439)|Lung NSC(277;0.00683)|all_epithelial(167;0.00728)		Colorectal(144;0.0314)|Lung(183;0.0924)|COAD - Colon adenocarcinoma(174;0.119)|Epithelial(280;0.173)|all cancers(265;0.244)		CTTTCAGCTCCCTGTTGTCCT	0.552000													30	86					0	0	0.002445	0	0
SBSPON	157869	broad.mit.edu	37	8	73993429	73993429	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:73993429C>T	ENST00000297354.6	-	2	438	c.234G>A	c.(232-234)ggG>ggA	p.G78G	SBSPON_ENST00000519697.1_5'UTR	NM_153225.3	NP_694957.3	Q8IVN8	RPESP_HUMAN	somatomedin B and thrombospondin, type 1 domain containing	78	TSP type-1.				immune response	extracellular region	polysaccharide binding|scavenger receptor activity										GGCTCCATTCCCCCACGAAGC	0.627000													9	65					0	0	0.006214	0	0
NPY2R	4887	broad.mit.edu	37	4	156136099	156136099	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:156136099C>T	ENST00000329476.3	+	2	1497	c.1008C>T	c.(1006-1008)ttC>ttT	p.F336F	NPY2R_ENST00000506608.1_Silent_p.F336F	NM_000910.2	NP_000901.1	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	336					cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(17)|prostate(1)|skin(5)|urinary_tract(1)	36	all_hematologic(180;0.24)	Renal(120;0.0854)				GAAAGGCTTTCCTCTCGGCCT	0.498000													24	40					0	0	0.004656	0	0
XPNPEP2	7512	broad.mit.edu	37	X	128902303	128902303	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:128902303G>A	ENST00000371106.3	+	21	2059	c.1867G>A	c.(1867-1869)Gag>Aag	p.E623K		NM_003399.5	NP_003390.4	O43895	XPP2_HUMAN	X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound	623					cellular process|proteolysis	anchored to membrane|plasma membrane	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(5)|liver(1)|lung(20)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)	37						GACCATCCGGGAGAAGGTGGG	0.602000													19	2					0	0	0.002299	0	0
THUMPD2	80745	broad.mit.edu	37	2	39993221	39993221	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:39993221G>A	ENST00000505747.1	-	5	806	c.779C>T	c.(778-780)tCt>tTt	p.S260F	THUMPD2_ENST00000454352.2_3'UTR|THUMPD2_ENST00000260619.6_Missense_Mutation_p.S230F	NM_025264.4	NP_079540.2	Q9BTF0	THUM2_HUMAN	THUMP domain containing 2	260	THUMP.						methyltransferase activity			endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|skin(1)	17		all_hematologic(82;0.248)				CCCCACCACAGAGTAAATGTC	0.328000													27	86					0	0	0.002096	0	0
DNAJA2	10294	broad.mit.edu	37	16	47001558	47001558	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:47001558G>A	ENST00000317089.5	-	5	659	c.443_splice	c.e5-1	p.G148_splice		NM_005880.3	NP_005871.1	O60884	DNJA2_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 2	148					positive regulation of cell proliferation|protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(2)|upper_aerodigestive_tract(1)	14		all_cancers(37;0.00125)|all_lung(18;0.00338)|all_epithelial(9;0.00358)|Lung NSC(13;0.0309)|Breast(268;0.116)				TTCCGCCTTGGCTAAAGCAAG	0.468000													40	39					0	0	0.003610	0	0
KIF14	9928	broad.mit.edu	37	1	200571082	200571082	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:200571082G>A	ENST00000367350.4	-	11	2532	c.2094C>T	c.(2092-2094)gcC>gcT	p.A698A		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	698					microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						CTATTAAACGGGCTTGGTTAG	0.353000													28	111					0	0	0.002096	0	0
IFT57	55081	broad.mit.edu	37	3	107932859	107932859	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:107932859G>A	ENST00000264538.3	-	4	751	c.504C>T	c.(502-504)taC>taT	p.Y168Y		NM_018010.3	NP_060480.1	Q9NWB7	IFT57_HUMAN	intraflagellar transport 57 homolog (Chlamydomonas)	168					activation of caspase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cilium|microtubule basal body	DNA binding|protein binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(2)	14			OV - Ovarian serous cystadenocarcinoma(3;0.0428)|Epithelial(53;0.246)			CTTCTACTGGGTATATTGGCC	0.308000													7	27					0	0	0.006214	0	0
BATF	10538	broad.mit.edu	37	14	76012946	76012946	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:76012946C>T	ENST00000286639.6	+	3	568	c.310C>T	c.(310-312)Ccc>Tcc	p.P104S	BATF_ENST00000555795.1_3'UTR|BATF_ENST00000555504.1_Intron	NM_006399.3	NP_006390.1	Q16520	BATF_HUMAN	basic leucine zipper transcription factor, ATF-like	104						nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			large_intestine(1)|ovary(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.028)		GCCCTCGCCCCCCGAGGTGGT	0.652000													5	8					0	0	0.001168	0	0
ZNF99	7652	broad.mit.edu	37	19	22952081	22952081	+	Missense_Mutation	SNP	C	C	T	rs149345966	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:22952081C>T	ENST00000397104.3	-	2	111	c.112G>A	c.(112-114)Gag>Aag	p.E38K	ZNF99_ENST00000596209.1_Missense_Mutation_p.E17K					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CATTGCCACTCCTCCAGAGCG	0.403000													16	22					0	0	0.004007	0	0
LRRC1	55227	broad.mit.edu	37	6	53707025	53707025	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:53707025G>A	ENST00000370888.1	+	2	554	c.277_splice	c.e2+1	p.E93_splice	LRRC1_ENST00000370882.1_Splice_Site_p.E93_splice	NM_018214.4	NP_060684.4	Q9BTT6	LRRC1_HUMAN	leucine rich repeat containing 1	93						cytoplasm|membrane				cervix(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		GTCTCGAAATGGTAAGAAAGA	0.418000													34	152					0	0	0.003755	0	0
KRTAP12-4	386684	broad.mit.edu	37	21	46074232	46074232	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:46074232G>A	ENST00000391618.1	-	1	344	c.300C>T	c.(298-300)gtC>gtT	p.V100V	TSPEAR_ENST00000323084.4_Intron	NM_198698.1	NP_941971.1	P60329	KR124_HUMAN	keratin associated protein 12-4	100	15 X 5 AA approximate repeats.					keratin filament				lung(4)|ovary(1)|prostate(1)	6						CAGGTCTATAGACCAGGGTGG	0.612000													13	23					0	0	0.002450	0	0
RICTOR	253260	broad.mit.edu	37	5	38954908	38954908	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:38954908G>A	ENST00000357387.3	-	27	2695	c.2665C>T	c.(2665-2667)Cat>Tat	p.H889Y	RICTOR_ENST00000296782.5_Missense_Mutation_p.H889Y|RICTOR_ENST00000503698.1_5'UTR	NM_152756.3	NP_689969.2	Q6R327	RICTR_HUMAN	RPTOR independent companion of MTOR, complex 2	889					actin cytoskeleton reorganization|embryo development|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|regulation of protein kinase B signaling cascade|T cell costimulation	cytosol|TORC2 complex	protein binding	p.H889N(1)		NS(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(33)|ovary(3)|prostate(3)|skin(5)	75	all_lung(31;0.000396)					CCTGTTTTATGGTGTACTAGT	0.313000													35	67					0	0	0.006230	0	0
ZIM3	114026	broad.mit.edu	37	19	57646553	57646553	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57646553G>A	ENST00000269834.1	-	5	1537	c.1152C>T	c.(1150-1152)atC>atT	p.I384I		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	384					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCCCAGTATGGATTTTTTTAT	0.388000													41	96					0	0	0.006999	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1893687	1893687	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:1893687C>T	ENST00000518288.1	+	28	3498	c.3335C>T	c.(3334-3336)tCc>tTc	p.S1112F	ARHGEF10_ENST00000398564.1_Missense_Mutation_p.S1113F|ARHGEF10_ENST00000349830.3_Missense_Mutation_p.S1088F|ARHGEF10_ENST00000521927.1_3'UTR|ARHGEF10_ENST00000262112.6_Missense_Mutation_p.S1084F|ARHGEF10_ENST00000520359.1_Missense_Mutation_p.S1050F			O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10	1113					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			endometrium(3)|large_intestine(11)|lung(11)|prostate(3)|skin(3)|stomach(3)|urinary_tract(1)	35		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		ATGGTGATCTCCCACATGGCC	0.597000													3	9					0	0	0.004672	0	0
GRAP2	9402	broad.mit.edu	37	22	40365475	40365475	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:40365475G>C	ENST00000344138.4	+	7	1014	c.751G>C	c.(751-753)Gaa>Caa	p.E251Q	GRAP2_ENST00000399090.2_Missense_Mutation_p.E138Q|GRAP2_ENST00000543252.1_Missense_Mutation_p.E211Q|GRAP2_ENST00000540310.1_Missense_Mutation_p.E185Q|GRAP2_ENST00000407075.3_Missense_Mutation_p.E251Q|GRAP2_ENST00000544756.1_Missense_Mutation_p.E179Q	NM_004810.2	NP_004801.1	O75791	GRAP2_HUMAN	GRB2-related adaptor protein 2	251					cell-cell signaling|Ras protein signal transduction|T cell costimulation|T cell receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						CTTGGGCAGTGAAATGAATGC	0.572000													24	65					0	0	0.004656	0	0
THBS1	7057	broad.mit.edu	37	15	39885722	39885722	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:39885722G>A	ENST00000260356.5	+	19	3285	c.3120G>A	c.(3118-3120)tgG>tgA	p.W1040*		NM_003246.2	NP_003237.2	P07996	TSP1_HUMAN	thrombospondin 1	1040	TSP C-terminal.				activation of MAPK activity|anti-apoptosis|apoptosis|cell adhesion|cell cycle arrest|cell migration|cellular response to heat|chronic inflammatory response|engulfment of apoptotic cell|immune response|induction of apoptosis|negative regulation of angiogenesis|negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|negative regulation of blood vessel endothelial cell migration|negative regulation of caspase activity|negative regulation of cGMP-mediated signaling|negative regulation of dendritic cell antigen processing and presentation|negative regulation of endothelial cell proliferation|negative regulation of fibrinolysis|negative regulation of fibroblast growth factor receptor signaling pathway|negative regulation of focal adhesion assembly|negative regulation of interleukin-12 production|negative regulation of nitric oxide mediated signal transduction|negative regulation of plasma membrane long-chain fatty acid transport|negative regulation of plasminogen activation|peptide cross-linking|platelet activation|platelet degranulation|positive regulation of angiogenesis|positive regulation of blood vessel endothelial cell migration|positive regulation of fibroblast migration|positive regulation of macrophage activation|positive regulation of macrophage chemotaxis|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transforming growth factor-beta1 production|positive regulation of translation|positive regulation of tumor necrosis factor biosynthetic process|response to calcium ion|response to drug|response to glucose stimulus|response to hypoxia|response to magnesium ion|response to progesterone stimulus|sprouting angiogenesis	external side of plasma membrane|extracellular matrix|fibrinogen complex|platelet alpha granule lumen	calcium ion binding|collagen V binding|eukaryotic cell surface binding|fibrinogen binding|fibroblast growth factor 2 binding|fibronectin binding|heparin binding|identical protein binding|integrin binding|laminin binding|low-density lipoprotein particle binding|phosphatidylserine binding|proteoglycan binding|structural molecule activity|transforming growth factor beta binding			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(5)|large_intestine(15)|lung(9)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	53		all_cancers(109;1.35e-17)|all_epithelial(112;2.07e-15)|Lung NSC(122;4.44e-11)|all_lung(180;1.11e-09)|Melanoma(134;0.0574)|Colorectal(260;0.117)|Ovarian(310;0.223)		GBM - Glioblastoma multiforme(113;2.77e-06)|BRCA - Breast invasive adenocarcinoma(123;0.105)	Becaplermin(DB00102)	TTGTGATGTGGAAGCAAGTCA	0.532000													33	43					0	0	0.002836	0	0
LINC00674	100499466	broad.mit.edu	37	17	66110660	66110660	+	RNA	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:66110660T>C	ENST00000435469.2	+	0	214																											TACGGAGGGGTTGCCAGGTAA	0.393000													3	7					0	0	0.004672	0	0
OR10J3	441911	broad.mit.edu	37	1	159283829	159283829	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:159283829G>A	ENST00000332217.5	-	1	620	c.621C>T	c.(619-621)gtC>gtT	p.V207V		NM_001004467.1	NP_001004467.1	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J, member 3	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V207V(1)		breast(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(19)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	47	all_hematologic(112;0.0429)					GTAGAACAAGGACACAGACGC	0.478000													22	104					0	0	0.002299	0	0
GRPEL2	134266	broad.mit.edu	37	5	148727857	148727857	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:148727857A>T	ENST00000329271.3	+	2	210	c.100A>T	c.(100-102)Act>Tct	p.T34S	GRPEL2_ENST00000513661.1_Missense_Mutation_p.T34S|RP11-394O4.4_ENST00000521295.1_RNA|GRPEL2_ENST00000416916.2_Missense_Mutation_p.T34S|GRPEL2_ENST00000507562.1_3'UTR	NM_152407.3	NP_689620.2	Q8TAA5	GRPE2_HUMAN	GrpE-like 2, mitochondrial (E. coli)	34					protein folding	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCCATTCAGCACTGCCACCCA	0.512000													56	73					0	0	0.003610	0	0
TGS1	96764	broad.mit.edu	37	8	56699515	56699515	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:56699515G>A	ENST00000260129.5	+	4	1535	c.1058G>A	c.(1057-1059)aGc>aAc	p.S353N		NM_024831.6	NP_079107.6	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase 1	353					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			GAAGTTAGTAGCAAAAGAGAG	0.438000													22	83					0	0	0.001882	0	0
PPFIA1	8500	broad.mit.edu	37	11	70194330	70194330	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:70194330G>T	ENST00000253925.7	+	16	2182	c.1967G>T	c.(1966-1968)cGg>cTg	p.R656L	PPFIA1_ENST00000389547.3_Missense_Mutation_p.R656L|AP000487.6_ENST00000528607.1_RNA	NM_003626.3	NP_003617.1	Q13136	LIPA1_HUMAN	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1	656					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			breast(3)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	65			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			ACAGAGCAGCGGGCAGAGGAG	0.438000													9	394					0.000274275	0.000464203	0.004482	1	0
DONSON	29980	broad.mit.edu	37	21	34958419	34958419	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:34958419C>G	ENST00000453626.1	-	3	475	c.471G>C	c.(469-471)tgG>tgC	p.W157C	AP000304.12_ENST00000429238.1_Missense_Mutation_p.E119Q|DONSON_ENST00000303113.6_Missense_Mutation_p.W157C|DONSON_ENST00000303071.5_Missense_Mutation_p.W157C|DONSON_ENST00000432378.1_Missense_Mutation_p.W157C			Q9NYP3	DONS_HUMAN	downstream neighbor of SON	157					multicellular organismal development	nucleus				central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(1)|ovary(1)	11						TTTTAATACTCCAGTCCACAG	0.418000											OREG0003565	type=REGULATORY REGION|Gene=DONSON|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	19					0	0	0.001984	0	0
APPL2	55198	broad.mit.edu	37	12	105591619	105591619	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:105591619C>T	ENST00000258530.3	-	11	1201	c.976G>A	c.(976-978)Gac>Aac	p.D326N	APPL2_ENST00000551662.1_Missense_Mutation_p.D332N|APPL2_ENST00000549573.1_5'UTR|APPL2_ENST00000539978.2_Missense_Mutation_p.D283N	NM_001251904.1|NM_018171.3	NP_001238833.1|NP_060641.2	Q8NEU8	DP13B_HUMAN	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	326	PH.|Required for RAB5A binding (By similarity).				cell cycle|cell proliferation|signal transduction	early endosome membrane|nucleus	protein binding			breast(1)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						GAGCAGTTGTCCAGGTCCTGG	0.552000													17	48					0	0	0.004990	0	0
GGT5	2687	broad.mit.edu	37	22	24622695	24622695	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:24622695C>T	ENST00000327365.4	-	7	1358	c.942G>A	c.(940-942)ggG>ggA	p.G314G	GGT5_ENST00000398292.3_Silent_p.G314G|GGT5_ENST00000263112.7_Silent_p.G282G|GGT5_ENST00000418439.2_Silent_p.G237G	NM_001099781.1|NM_004121.2	NP_001093251.1|NP_004112.2	P36269	GGT5_HUMAN	gamma-glutamyltransferase 5	314					glutathione biosynthetic process|hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	integral to membrane|plasma membrane	acyltransferase activity|gamma-glutamyltransferase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(3)|skin(3)	28						CGTTCACCCTCCCTTCAGGCC	0.572000													36	67					0	0	0.006999	0	0
SORCS1	114815	broad.mit.edu	37	10	108339231	108339231	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:108339231G>A	ENST00000263054.6	-	25	3274	c.3265_splice	c.e25-1	p.A1089_splice	SORCS1_ENST00000369698.1_Splice_Site_p.A624_splice|SORCS1_ENST00000344440.6_Splice_Site_p.A1089_splice	NM_001206570.1|NM_052918.4	NP_001193499.1|NP_443150.3	Q8WY21	SORC1_HUMAN	sortilin-related VPS10 domain containing receptor 1	1089						integral to membrane	neuropeptide receptor activity|protein binding			breast(5)|central_nervous_system(1)|cervix(2)|endometrium(9)|kidney(2)|large_intestine(24)|lung(69)|ovary(1)|prostate(8)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	127		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		CCACCAGGGGGGCTTGTGGGG	0.522000													13	32					0	0	0.001368	0	0
RNF34	80196	broad.mit.edu	37	12	121867907	121867907	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:121867907G>A	ENST00000392464.2	+	7	1203	c.1134G>A	c.(1132-1134)agG>agA	p.R378R	KDM2B_ENST00000377071.4_3'UTR|KDM2B_ENST00000377069.4_3'UTR|KDM2B_ENST00000536437.1_3'UTR|KDM2B_ENST00000542973.1_3'UTR			Q969K3	RNF34_HUMAN	ring finger protein 34, E3 ubiquitin protein ligase	0					apoptosis	endomembrane system|membrane|nuclear speck	ligase activity|zinc ion binding			breast(1)|large_intestine(1)	2	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000432)|Epithelial(86;0.00233)		AAGACCAAAGGAAAGTGTCGG	0.498000													33	80					0	0	0.002836	0	0
PROKR2	128674	broad.mit.edu	37	20	5283349	5283349	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:5283349C>T	ENST00000546004.1	-	3	738	c.492G>A	c.(490-492)cgG>cgA	p.R164R	PROKR2_ENST00000217270.3_Silent_p.R164R			Q8NFJ6	PKR2_HUMAN	prokineticin receptor 2	164			R -> Q (in KAL3).			integral to membrane|plasma membrane	neuropeptide Y receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(3)|lung(22)|ovary(5)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	53						GATAATTCATCCGTGGTTTCA	0.488000										HNSCC(71;0.22)			36	131					0	0	0.005524	0	0
TGM1	7051	broad.mit.edu	37	14	24728447	24728447	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:24728447G>A	ENST00000206765.6	-	7	1116	c.993C>T	c.(991-993)tcC>tcT	p.S331S	TGM1_ENST00000544573.1_Intron	NM_000359.2	NP_000350.1	P22735	TGM1_HUMAN	transglutaminase 1	331			S -> P (in ARCI-TGM1).		cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(5)|lung(7)|ovary(2)|prostate(2)	24				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	TGTCATCCAGGGAGTTCACCT	0.622000													4	6					0	0	0.000248	0	0
STXBP5L	9515	broad.mit.edu	37	3	120973808	120973808	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:120973808G>A	ENST00000273666.6	+	16	1779	c.1508G>A	c.(1507-1509)gGa>gAa	p.G503E	STXBP5L_ENST00000492541.1_Missense_Mutation_p.G503E|STXBP5L_ENST00000497029.1_Missense_Mutation_p.G503E|STXBP5L_ENST00000471454.1_Missense_Mutation_p.G503E|STXBP5L_ENST00000472879.1_Missense_Mutation_p.G503E	NM_014980.2	NP_055795.1	Q9Y2K9	STB5L_HUMAN	syntaxin binding protein 5-like	503					exocytosis|protein transport	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(12)|lung(28)|ovary(7)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	68				GBM - Glioblastoma multiforme(114;0.0694)		GTAGGAGAAGGAAAACAAACA	0.378000													7	30					0	0	0.004482	0	0
UNC5B	219699	broad.mit.edu	37	10	73053615	73053615	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:73053615C>T	ENST00000335350.6	+	13	2516	c.2100C>T	c.(2098-2100)ttC>ttT	p.F700F	UNC5B_ENST00000373192.4_Silent_p.F689F	NM_170744.4	NP_734465.2	Q8IZJ1	UNC5B_HUMAN	unc-5 homolog B (C. elegans)	700					apoptosis|axon guidance|regulation of apoptosis	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(17)|ovary(4)|prostate(4)|skin(4)	49						TGGCCGTCTTCGCCCCCGCCC	0.657000													4	2					0	0	0.001168	0	0
CNGA3	1261	broad.mit.edu	37	2	99013380	99013380	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:99013380G>A	ENST00000393504.1	+	8	2164	c.1747G>A	c.(1747-1749)Gat>Aat	p.D583N	CNGA3_ENST00000436404.2_Missense_Mutation_p.D565N|CNGA3_ENST00000409937.1_Missense_Mutation_p.D587N|CNGA3_ENST00000272602.2_Missense_Mutation_p.D583N	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	583					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						CTCAAAGGACGATCTCATGGA	0.562000													16	31					0	0	0.003163	0	0
DLGAP3	58512	broad.mit.edu	37	1	35370480	35370480	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:35370480G>A	ENST00000373347.1	-	3	773	c.505C>T	c.(505-507)Cgc>Tgc	p.R169C	DLGAP3_ENST00000235180.4_Missense_Mutation_p.R169C			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	169					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				TGCCGGATGCGGCTAGGGCTC	0.667000													11	32					0	0	0.002450	0	0
PTPRB	5787	broad.mit.edu	37	12	70946726	70946726	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:70946726G>A	ENST00000334414.6	-	21	5262	c.5218C>T	c.(5218-5220)Cgg>Tgg	p.R1740W	PTPRB_ENST00000550857.1_Missense_Mutation_p.R1432W|PTPRB_ENST00000538708.1_Missense_Mutation_p.R1432W|PTPRB_ENST00000261266.5_Missense_Mutation_p.R1522W|PTPRB_ENST00000550358.1_Missense_Mutation_p.R1652W|PTPRB_ENST00000451516.2_Missense_Mutation_p.R1432W	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1522	Tyrosine-protein phosphatase.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			TGATACACCCGAATGGAGGCA	0.483000													49	105					0	0	0.003610	0	0
SLC12A5	57468	broad.mit.edu	37	20	44672558	44672558	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:44672558C>T	ENST00000454036.1	+	11	1525	c.1449C>T	c.(1447-1449)gtC>gtT	p.V483V	SLC12A5_ENST00000243964.3_Silent_p.V460V|SLC12A5_ENST00000539566.1_Intron	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	483					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TTGAGGGGGTCGTCCTGCGGG	0.557000													31	85					0	0	0.003271	0	0
ASTN1	460	broad.mit.edu	37	1	177001815	177001815	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:177001815C>T	ENST00000367654.2	-	3	655	c.642G>A	c.(640-642)cgG>cgA	p.R214R	ASTN1_ENST00000361833.2_Silent_p.R214R|ASTN1_ENST00000281881.3_5'UTR|ASTN1_ENST00000424564.2_Silent_p.R214R|ASTN1_ENST00000367657.3_Silent_p.R214R			O14525	ASTN1_HUMAN	astrotactin 1	214					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GCAGGCTCTCCCGTCCGTGCC	0.622000													36	14					0	0	0.005524	0	0
CD163	9332	broad.mit.edu	37	12	7637816	7637816	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:7637816G>A	ENST00000359156.4	-	11	2857	c.2655C>T	c.(2653-2655)tcC>tcT	p.S885S	CD163_ENST00000541972.1_Silent_p.S873S|CD163_ENST00000432237.2_Silent_p.S885S|CD163_ENST00000539632.1_5'UTR|CD163_ENST00000396620.3_Silent_p.S918S	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	885	SRCR 8.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						ACATGGGAATGGACATGGCCT	0.547000													21	35					0	0	0.001523	0	0
GIMAP6	474344	broad.mit.edu	37	7	150325516	150325516	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:150325516C>T	ENST00000328902.5	-	3	386	c.170G>A	c.(169-171)gGa>gAa	p.G57E	GIMAP6_ENST00000493969.1_Intron	NM_001244072.1|NM_024711.5	NP_001231001.1|NP_078987.3	Q6P9H5	GIMA6_HUMAN	GTPase, IMAP family member 6	57							GTP binding			endometrium(4)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	29			OV - Ovarian serous cystadenocarcinoma(82;0.0145)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GATGCTGTTTCCTGTTGCACT	0.542000													95	127					0	0	0.003610	0	0
KRT71	112802	broad.mit.edu	37	12	52940286	52940286	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:52940286G>A	ENST00000267119.5	-	7	1178	c.1109C>T	c.(1108-1110)tCc>tTc	p.S370F		NM_033448.2	NP_258259.1	Q3SY84	K2C71_HUMAN	keratin 71	370	Coil 2.|Rod.						structural molecule activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.194)		CTCCAGGTTGGAAGCCTAAGG	0.597000													7	16					0	0	0.001984	0	0
TRIOBP	11078	broad.mit.edu	37	22	38131177	38131177	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:38131177G>A	ENST00000406386.3	+	9	5089	c.4834G>A	c.(4834-4836)Gag>Aag	p.E1612K	RP1-37E16.12_ENST00000455236.1_RNA	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	1612					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					TTTAGGGCCAGAGCTGGGTCC	0.672000											OREG0026548	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	83	13					0	0	0.003610	0	0
LIX1L	128077	broad.mit.edu	37	1	145492310	145492310	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:145492310C>T	ENST00000369308.3	+	3	606	c.532C>T	c.(532-534)Cct>Tct	p.P178S	RP11-315I20.1_ENST00000437207.1_RNA|RP11-315I20.1_ENST00000600340.1_RNA|RP11-315I20.1_ENST00000599469.1_RNA|RP11-315I20.1_ENST00000598354.1_RNA|RP11-315I20.1_ENST00000598103.1_RNA|RP11-315I20.1_ENST00000597144.1_RNA|RP11-315I20.1_ENST00000595518.1_RNA	NM_153713.1	NP_714924.1	Q8IVB5	LIX1L_HUMAN	Lix1 homolog (mouse)-like	178										large_intestine(4)|lung(6)|ovary(2)|skin(1)	13	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					TAATGAACATCCTTCCCGAAG	0.478000													37	73					0	0	0.004878	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3687199	3687199	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:3687199C>T	ENST00000344754.4	-	2	203	c.204G>A	c.(202-204)caG>caA	p.Q68Q	SIGLEC1_ENST00000202578.4_Silent_p.Q68Q	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	68	Ig-like V-type.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						GGCTCACCACCTGCCGCTGGC	0.667000													4	18					0	0	0.000248	0	0
ADAMTSL1	92949	broad.mit.edu	37	9	18777260	18777260	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:18777260G>A	ENST00000380548.4	+	19	3372	c.3033G>A	c.(3031-3033)cgG>cgA	p.R1011R		NM_001040272.5	NP_001035362.3	Q8N6G6	ATL1_HUMAN	ADAMTS-like 1	1011						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(2)|lung(17)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	42				GBM - Glioblastoma multiforme(50;1.29e-17)		CGGAGAAGCGGGGCCTGGCCG	0.706000													10	6					0	0	0.000673	0	0
PSG5	5673	broad.mit.edu	37	19	43680138	43680138	+	Missense_Mutation	SNP	T	T	C	rs147160846		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:43680138T>C	ENST00000404580.1	-	3	681	c.593A>G	c.(592-594)gAa>gGa	p.E198G	PSG5_ENST00000342951.6_Missense_Mutation_p.E198G|PSG5_ENST00000599812.1_Missense_Mutation_p.E291G|PSG5_ENST00000407356.1_Missense_Mutation_p.E198G|PSG5_ENST00000366175.3_Missense_Mutation_p.E198G|PSG5_ENST00000407568.1_Intron			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	198	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				GATCCTGTTTTCAATGGGTCG	0.502000													67	115					0	0	0.003610	0	0
FLRT2	23768	broad.mit.edu	37	14	86088580	86088580	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:86088580C>T	ENST00000330753.4	+	2	1489	c.722C>T	c.(721-723)tCg>tTg	p.S241L	FLRT2_ENST00000554746.1_Missense_Mutation_p.S241L	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	241					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GTACGTAATTCGCTGTCCCAC	0.502000													28	32					0	0	0.004656	0	0
ABCA13	154664	broad.mit.edu	37	7	48319316	48319316	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:48319316G>A	ENST00000435803.1	+	18	8549	c.8525G>A	c.(8524-8526)aGa>aAa	p.R2842K		NM_152701.3	NP_689914.2	Q86UQ4	ABCAD_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 13	2842					transport	integral to membrane	ATP binding|ATPase activity			breast(13)|central_nervous_system(8)|endometrium(25)|haematopoietic_and_lymphoid_tissue(4)|kidney(20)|large_intestine(51)|lung(100)|ovary(5)|pancreas(2)|prostate(22)|skin(10)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(4)	270						ACTTCCACAAGAACTTTGTTT	0.358000													45	76					0	0	0.003610	0	0
ACOX3	8310	broad.mit.edu	37	4	8383294	8383294	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:8383294G>A	ENST00000356406.5	-	14	1655	c.1578C>T	c.(1576-1578)ctC>ctT	p.L526L	ACOX3_ENST00000413009.2_Silent_p.L526L|ACOX3_ENST00000503233.1_Silent_p.L526L	NM_003501.2	NP_003492.2	O15254	ACOX3_HUMAN	acyl-CoA oxidase 3, pristanoyl	526					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(17)|prostate(1)|skin(3)|stomach(1)	42						AAGTCTCTCGGAGCAGGTAGC	0.408000													32	157					0	0	0.002836	0	0
SYNE2	23224	broad.mit.edu	37	14	64519208	64519208	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:64519208C>T	ENST00000358025.3	+	48	8807	c.8577C>T	c.(8575-8577)ccC>ccT	p.P2859P	SYNE2_ENST00000344113.4_Silent_p.P2859P|SYNE2_ENST00000357395.3_5'UTR|SYNE2_ENST00000554584.1_Silent_p.P2892P	NM_182914.2	NP_878918.2	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	2859					centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			NS(5)|breast(17)|central_nervous_system(3)|cervix(8)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(21)|large_intestine(34)|lung(75)|ovary(10)|pancreas(2)|prostate(8)|skin(8)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(4)	224				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TGATAATTCCCAGGGTGGAGA	0.378000													28	34					0	0	0.007291	0	0
C1orf172	126695	broad.mit.edu	37	1	27278866	27278866	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:27278866G>A	ENST00000320567.5	-	2	94	c.6C>T	c.(4-6)ccC>ccT	p.P2P		NM_152365.2	NP_689578.2	Q8NAX2	CA172_HUMAN	chromosome 1 open reading frame 172	2	Pro-rich.									NS(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	17		all_cancers(24;1.29e-21)|all_epithelial(13;2.35e-19)|Colorectal(325;0.000147)|all_lung(284;0.00122)|Lung NSC(340;0.00128)|Breast(348;0.00131)|Renal(390;0.00211)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0707)|all_neural(195;0.0966)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|Epithelial(14;3.37e-51)|OV - Ovarian serous cystadenocarcinoma(117;2.22e-29)|Colorectal(126;5.31e-09)|COAD - Colon adenocarcinoma(152;9.31e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000272)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|READ - Rectum adenocarcinoma(331;0.0419)		GTCCAGGGCGGGGCATGGCTC	0.617000													22	65					0	0	0.004656	0	0
STRC	161497	broad.mit.edu	37	15	43893725	43893725	+	Missense_Mutation	SNP	G	G	A	rs147990592		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:43893725G>A	ENST00000450892.2	-	24	4647	c.4570C>T	c.(4570-4572)Cgt>Tgt	p.R1524C	STRC_ENST00000541030.1_Missense_Mutation_p.R751C	NM_153700.2	NP_714544.1	Q7RTU9	STRC_HUMAN	stereocilin	1524					sensory perception of sound	cell surface		p.R1524G(1)		skin(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)		TGCTCAGGACGAAATCCCCGG	0.532000													17	21					0	0	0.006122	0	0
TTLL2	83887	broad.mit.edu	37	6	167755030	167755030	+	Missense_Mutation	SNP	G	G	A	rs111648937		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:167755030G>A	ENST00000239587.5	+	3	1730	c.1642G>A	c.(1642-1644)Gct>Act	p.A548T		NM_031949.4	NP_114155.4	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	548					protein modification process		ATP binding|tubulin-tyrosine ligase activity			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		CCGTGGCAAAGCTCCAGATCC	0.507000													32	43					0	0	0.003755	0	0
CCDC66	285331	broad.mit.edu	37	3	56627979	56627979	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:56627979C>T	ENST00000394672.3	+	10	1397	c.1327C>T	c.(1327-1329)Cgt>Tgt	p.R443C	CCDC66_ENST00000326595.7_Missense_Mutation_p.R409C|CCDC66_ENST00000436465.2_Missense_Mutation_p.R443C	NM_001012506.4|NM_001141947.1	NP_001012524.4|NP_001135419.1	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66	443										breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		CAGCTTTCTCCGTTCTATGAC	0.363000													13	47					0	0	0.001855	0	0
MEI1	150365	broad.mit.edu	37	22	42166716	42166716	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:42166716C>T	ENST00000401548.3	+	20	2335	c.2295C>T	c.(2293-2295)ttC>ttT	p.F765F	MEI1_ENST00000400107.1_Silent_p.F133F|MEI1_ENST00000540880.1_Silent_p.F83F|MEI1_ENST00000300398.4_5'UTR	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	765							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						TCAGAAAATTCCTAGAAGGCA	0.488000													4	23					0	0	0.000248	0	0
GPATCH1	55094	broad.mit.edu	37	19	33608800	33608800	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:33608800G>A	ENST00000170564.2	+	16	2580	c.2266G>A	c.(2266-2268)Gcc>Acc	p.A756T		NM_018025.2	NP_060495.2	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	756						catalytic step 2 spliceosome	nucleic acid binding			breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|prostate(4)|skin(4)	40	Esophageal squamous(110;0.137)					CTTATTCAGGGCCATCTTTGC	0.517000													31	287					0	0	0.002445	0	0
HARBI1	283254	broad.mit.edu	37	11	46637408	46637408	+	Missense_Mutation	SNP	G	G	A	rs141436294		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:46637408G>A	ENST00000326737.3	-	2	627	c.380C>T	c.(379-381)tCc>tTc	p.S127F		NM_173811.3	NP_776172.1	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	127						cytoplasm|nucleus	metal ion binding|nuclease activity			large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)	3						AGCCTGAATGGAGGCTTCATC	0.517000													48	84					0	0	0.003610	0	0
FREM1	158326	broad.mit.edu	37	9	14750232	14750232	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:14750232C>T	ENST00000380881.4	-	31	6268	c.5453G>A	c.(5452-5454)gGa>gAa	p.G1818E	FREM1_ENST00000380880.3_Missense_Mutation_p.G1817E|FREM1_ENST00000422223.2_Missense_Mutation_p.G1817E|FREM1_ENST00000380894.1_Missense_Mutation_p.G353E			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1817	Calx-beta.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		TTCCTCTAATCCGTCATAGGT	0.363000													24	56					0	0	0.002299	0	0
OGG1	4968	broad.mit.edu	37	3	9793459	9793459	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:9793459C>G	ENST00000302036.7	+	3	734	c.391C>G	c.(391-393)Cga>Gga	p.R131G	OGG1_ENST00000349503.5_Missense_Mutation_p.R131G|OGG1_ENST00000302008.8_Missense_Mutation_p.R131G|OGG1_ENST00000344629.7_Missense_Mutation_p.R131G|OGG1_ENST00000383826.5_Missense_Mutation_p.R131G|OGG1_ENST00000339511.5_Missense_Mutation_p.R131G|OGG1_ENST00000302003.7_Missense_Mutation_p.R131G|OGG1_ENST00000449570.2_Missense_Mutation_p.R131G	NM_016821.2	NP_058214.1	O15527	OGG1_HUMAN	8-oxoguanine DNA glycosylase	131			R -> Q (found in a lung cancer sample; loss of activity).		depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding			kidney(2)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	8	Medulloblastoma(99;0.227)					TCCAGGTGTGCGACTGCTGCG	0.557000								Base excision repair (BER), DNA glycosylases					41	110					0	0	0.002852	0	0
POU2F2	5452	broad.mit.edu	37	19	42600377	42600377	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:42600377G>A	ENST00000342301.4	-	8	586	c.520C>T	c.(520-522)Ctg>Ttg	p.L174L	POU2F2_ENST00000526816.2_Silent_p.L174L|POU2F2_ENST00000389341.5_Intron|POU2F2_ENST00000560398.1_Intron|POU2F2_ENST00000560558.1_Intron|POU2F2_ENST00000533720.1_Intron|POU2F2_ENST00000529952.1_Silent_p.L174L|POU2F2_ENST00000529067.1_Intron			P09086	PO2F2_HUMAN	POU class 2 homeobox 2	174					humoral immune response|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			kidney(1)|large_intestine(5)|lung(4)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Prostate(69;0.059)				GGGTCGGGCAGCGTAGGGCGG	0.701000													4	6					0	0	0.000602	0	0
ACSM1	116285	broad.mit.edu	37	16	20702372	20702372	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:20702372C>T	ENST00000307493.4	-	1	206	c.139G>A	c.(139-141)Gag>Aag	p.E47K	ACSM1_ENST00000219151.4_5'UTR|ACSM1_ENST00000520010.1_Missense_Mutation_p.E47K	NM_052956.2	NP_443188.2	Q08AH1	ACSM1_HUMAN	acyl-CoA synthetase medium-chain family member 1	47					benzoate metabolic process|butyrate metabolic process|energy derivation by oxidation of organic compounds|fatty acid oxidation|xenobiotic metabolic process	mitochondrial matrix	acyl-CoA ligase activity|ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(23)|skin(3)|upper_aerodigestive_tract(2)	42						TTAAATTCCTCCGGTACTTCA	0.488000													36	56					0	0	0.004289	0	0
GJA5	2702	broad.mit.edu	37	1	147230828	147230828	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:147230828G>A	ENST00000271348.2	-	2	680	c.519C>T	c.(517-519)ttC>ttT	p.F173F	GJA5_ENST00000369237.1_Silent_p.F173F	NM_005266.5|NM_181703.2	NP_005257.2|NP_859054.1	P36382	CXA5_HUMAN	gap junction protein, alpha 5, 40kDa	173					angiogenesis|cell-cell junction assembly|muscle contraction	integral to membrane				breast(3)|endometrium(2)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	20	all_hematologic(923;0.0276)		LUSC - Lung squamous cell carcinoma(543;0.202)			TTCCGTAGATGAAGTACTGGC	0.567000													16	28					0	0	0.003163	0	0
ALPI	248	broad.mit.edu	37	2	233321866	233321866	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:233321866C>T	ENST00000295463.3	+	5	559	c.482C>T	c.(481-483)tCa>tTa	p.S161L		NM_001631.3	NP_001622.2	P09923	PPBI_HUMAN	alkaline phosphatase, intestinal	161					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(2)|upper_aerodigestive_tract(1)	24		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TCAGGAAAGTCAGTAGGAGTG	0.627000													16	9					0	0	0.004990	0	0
MUC16	94025	broad.mit.edu	37	19	9049258	9049258	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9049258C>T	ENST00000397910.4	-	5	32576	c.32373G>A	c.(32371-32373)cgG>cgA	p.R10791R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	10793	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGGTCACCAACCGTGATACAG	0.493000													43	62					0	0	0.002522	0	0
MUC16	94025	broad.mit.edu	37	19	9060867	9060867	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9060867G>A	ENST00000397910.4	-	3	26782	c.26579C>T	c.(26578-26580)tCt>tTt	p.S8860F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8862	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGTTACTGCAGATAAAGACAC	0.517000													38	41					0	0	0.007835	0	0
DNAH3	55567	broad.mit.edu	37	16	21071604	21071604	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:21071604C>T	ENST00000261383.3	-	26	3793	c.3794G>A	c.(3793-3795)gGg>gAg	p.G1265E	DNAH3_ENST00000415178.1_Missense_Mutation_p.G1265E	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1265	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TGCTTCAATCCCAAGTCCAAT	0.502000													46	73					0	0	0.003610	0	0
ATP1A4	480	broad.mit.edu	37	1	160128877	160128877	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:160128877G>A	ENST00000368081.4	+	5	1082	c.611G>A	c.(610-612)gGa>gAa	p.G204E		NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	204					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			ATCAAGGGTGGAGACCGAGTC	0.512000													22	108					0	0	0.001882	0	0
MXRA5	25878	broad.mit.edu	37	X	3261814	3261814	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:3261814G>A	ENST00000217939.6	-	2	215	c.61C>T	c.(61-63)Ccg>Tcg	p.P21S		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	21						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCCACTCGCGGATGGCCCCAA	0.662000													4	0					0	0	0.000248	0	0
PAXIP1	22976	broad.mit.edu	37	7	154747269	154747269	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:154747269G>A	ENST00000404141.1	-	15	2776	c.2622C>T	c.(2620-2622)ttC>ttT	p.F874F	PAXIP1_ENST00000397192.1_Silent_p.F874F|PAXIP1_ENST00000473219.1_5'UTR			Q6ZW49	PAXI1_HUMAN	PAX interacting (with transcription-activation domain) protein 1	874	BRCT 5.|Interaction with TP53BP1.				DNA damage response, signal transduction by p53 class mediator|DNA recombination|DNA repair|histone H3-K4 methylation|positive regulation of histone acetylation|positive regulation of histone H3-K36 methylation|positive regulation of histone H3-K4 methylation|positive regulation of isotype switching|positive regulation of protein ubiquitination|positive regulation of transcription initiation from RNA polymerase II promoter|response to ionizing radiation|transcription, DNA-dependent	histone methyltransferase complex|nuclear matrix				NS(1)|breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	33	all_neural(206;0.119)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.0296)	UCEC - Uterine corpus endometrioid carcinoma (81;0.178)		GGACAGGCTCGAATCCAGTGA	0.363000													11	27					0	0	0.001855	0	0
SLC50A1	55974	broad.mit.edu	37	1	155108417	155108417	+	Silent	SNP	C	C	G	rs141021704		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:155108417C>G	ENST00000368404.4	+	1	92	c.30C>G	c.(28-30)ctC>ctG	p.L10L	SLC50A1_ENST00000368401.5_5'UTR|SLC50A1_ENST00000484157.1_Intron|SLC50A1_ENST00000303343.8_Silent_p.L10L|SLC50A1_ENST00000368405.3_3'UTR	NM_018845.3	NP_061333.2	Q9BRV3	SWET1_HUMAN	solute carrier family 50 (sugar efflux transporter), member 1	10	MtN3/slv 1.				positive regulation of gene expression, epigenetic	Golgi membrane|integral to membrane|plasma membrane	glucoside transmembrane transporter activity			endometrium(1)|lung(1)|ovary(1)|skin(1)	4						TGGACTCGCTCATTTACGGAG	0.662000													10	22					0	0	0.001368	0	0
IL7R	3575	broad.mit.edu	37	5	35876118	35876118	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:35876118C>T	ENST00000303115.3	+	8	1039	c.910C>T	c.(910-912)Ctg>Ttg	p.L304L	IL7R_ENST00000343305.4_3'UTR	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	304					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			TGAAAGTTTCCTGGACTGCCA	0.408000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						16	39					0	0	0.004007	0	0
LPPR4	9890	broad.mit.edu	37	1	99771774	99771774	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:99771774G>A	ENST00000370185.3	+	7	1997	c.1500G>A	c.(1498-1500)caG>caA	p.Q500Q	LPPR4_ENST00000370184.1_Silent_p.Q342Q|LPPR4_ENST00000457765.1_Silent_p.Q442Q	NM_014839.4	NP_055654.2	Q7Z2D5	LPPR4_HUMAN		500							phosphatidate phosphatase activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(39)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	72		all_epithelial(167;3.54e-06)|all_lung(203;0.00139)|Lung NSC(277;0.00202)		Epithelial(280;0.0736)|all cancers(265;0.0975)|COAD - Colon adenocarcinoma(174;0.142)|Lung(183;0.201)|Colorectal(170;0.22)		CTGGCAATCAGTACCTCAAAA	0.572000													58	90					0	0	0.003610	0	0
LRP8	7804	broad.mit.edu	37	1	53729861	53729861	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:53729861G>A	ENST00000306052.6	-	10	1736	c.1635C>T	c.(1633-1635)atC>atT	p.I545I	LRP8_ENST00000354412.3_Silent_p.I416I|LRP8_ENST00000347547.2_Silent_p.I375I|LRP8_ENST00000465675.1_Silent_p.I98I|LRP8_ENST00000371454.2_Silent_p.I545I	NM_004631.4	NP_004622.2	Q14114	LRP8_HUMAN	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	545					cytokine-mediated signaling pathway|endocytosis|lipid metabolic process|platelet activation|proteolysis	caveola	calcium ion binding|very-low-density lipoprotein particle receptor activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|prostate(2)|skin(1)	21						GGTCAACAGCGATGGCCCGGG	0.572000													16	15					0	0	0.003163	0	0
C2CD5	9847	broad.mit.edu	37	12	22623806	22623806	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:22623806G>A	ENST00000333957.4	-	21	2653	c.2398C>T	c.(2398-2400)Cag>Tag	p.Q800*	C2CD5_ENST00000545552.1_Nonsense_Mutation_p.Q813*|C2CD5_ENST00000542676.1_Nonsense_Mutation_p.Q800*|C2CD5_ENST00000536386.1_Nonsense_Mutation_p.Q802*|C2CD5_ENST00000396028.2_Nonsense_Mutation_p.Q791*|C2CD5_ENST00000544930.1_Nonsense_Mutation_p.Q615*|C2CD5_ENST00000446597.1_Nonsense_Mutation_p.Q800*	NM_014802.1	NP_055617.1			C2 calcium-dependent domain containing 5																		TGTAAAGCCTGATTTTTGTCA	0.343000													25	23					0	0	0.004656	0	0
HELZ2	85441	broad.mit.edu	37	20	62200328	62200328	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:62200328G>A	ENST00000467148.1	-	5	1182	c.1113C>T	c.(1111-1113)ttC>ttT	p.F371F		NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		CCGTCTTCAGGAACACCTGGC	0.677000													11	35					0	0	0.001368	0	0
SLC9C1	285335	broad.mit.edu	37	3	111997628	111997628	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:111997628A>T	ENST00000305815.5	-	4	518	c.266T>A	c.(265-267)tTt>tAt	p.F89Y	SLC9C1_ENST00000487372.1_Missense_Mutation_p.F89Y|SLC9C1_ENST00000467397.1_5'UTR	NM_183061.1	NP_898884.1	Q4G0N8	S9A10_HUMAN	solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1	89					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity										TGCAGTAGTAAAGAAAACTAC	0.318000													52	118					0	0	0.003610	0	0
AARS	16	broad.mit.edu	37	16	70286801	70286801	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:70286801G>A	ENST00000261772.8	-	21	2873	c.2730C>T	c.(2728-2730)gcC>gcT	p.A910A		NM_001605.2	NP_001596.2	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	910					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(3)|cervix(2)|endometrium(5)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	AGCCCCGATTGGCTGCATTCT	0.557000											OREG0023912	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	42					0	0	0.001216	0	0
SOCS2	8835	broad.mit.edu	37	12	93968784	93968784	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:93968784C>T	ENST00000340600.2	+	3	1024	c.426C>T	c.(424-426)gcC>gcT	p.A142A	SOCS2_ENST00000549206.1_Silent_p.A142A|SOCS2_ENST00000548537.1_3'UTR|SOCS2_ENST00000536696.2_Silent_p.A142A|SOCS2_ENST00000551556.1_Silent_p.A142A|SOCS2_ENST00000549122.1_Silent_p.A142A	NM_001270468.1|NM_001270469.1|NM_001270471.1|NM_003877.4	NP_001257397.1|NP_001257398.1|NP_001257400.1|NP_003868.1	O14508	SOCS2_HUMAN	suppressor of cytokine signaling 2	142	SH2.				anti-apoptosis|growth hormone receptor signaling pathway|JAK-STAT cascade|negative regulation of signal transduction|regulation of cell growth|response to estradiol stimulus	cytoplasm	growth hormone receptor binding|insulin-like growth factor receptor binding|JAK pathway signal transduction adaptor activity|prolactin receptor binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|ovary(1)	14						GTCCAGAAGCCCCCCGGAACG	0.473000													13	37					0	0	0.003163	0	0
GOLGA6C	653641	broad.mit.edu	37	15	75562480	75562480	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:75562480C>T	ENST00000300576.5	+	18	2022	c.2022C>T	c.(2020-2022)ccC>ccT	p.P674P		NM_001164404.1	NP_001157876.1	A6NDK9	GOG6C_HUMAN	golgin A6 family, member C	674										ovary(1)	1						AGGGTTCTCCCCATGACAACC	0.602000													21	81					0	0	0.001523	0	0
GUCY1B3	2983	broad.mit.edu	37	4	156725868	156725868	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:156725868G>A	ENST00000264424.8	+	12	1760	c.1678G>A	c.(1678-1680)Gga>Aga	p.G560R	GUCY1B3_ENST00000513437.1_Missense_Mutation_p.G492R|GUCY1B3_ENST00000507146.1_Missense_Mutation_p.G535R|GUCY1B3_ENST00000503520.1_Missense_Mutation_p.G527R|GUCY1B3_ENST00000505764.1_Missense_Mutation_p.G540R|GUCY1B3_ENST00000502959.1_Missense_Mutation_p.G582R|GUCY1B3_ENST00000505154.1_Missense_Mutation_p.G492R	NM_000857.2	NP_000848.1	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	560					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		AGGAGAAAAGGGAAAAATAAA	0.393000													9	14					0	0	0.004482	0	0
OSBPL5	114879	broad.mit.edu	37	11	3125455	3125455	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:3125455G>A	ENST00000263650.7	-	10	1371	c.1212C>T	c.(1210-1212)tcC>tcT	p.S404S	OSBPL5_ENST00000525498.1_Silent_p.S315S|OSBPL5_ENST00000542243.1_Silent_p.S35S|OSBPL5_ENST00000348039.5_Silent_p.S336S|OSBPL5_ENST00000389989.3_Silent_p.S336S	NM_020896.3	NP_065947.1	Q9H0X9	OSBL5_HUMAN	oxysterol binding protein-like 5	404					cholesterol metabolic process|cholesterol transport|Golgi to plasma membrane transport	cytosol	oxysterol binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(7)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	25		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		AGTAGTAGTCGGAGAGCTTGT	0.647000													18	19					0	0	0.007413	0	0
SERPINA3	12	broad.mit.edu	37	14	95081190	95081190	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:95081190G>A	ENST00000553947.1	+	5	1375	c.487G>A	c.(487-489)Gga>Aga	p.G163R	SERPINA3_ENST00000556388.1_Intron|SERPINA3_ENST00000393080.4_Missense_Mutation_p.G138R|SERPINA3_ENST00000467132.1_Missense_Mutation_p.G138R|SERPINA3_ENST00000393078.3_Missense_Mutation_p.G138R			P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3	138					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			NS(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(17)|ovary(2)|pancreas(1)|skin(3)|stomach(1)	40		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		GCTGAGTATGGGAAATGCCAT	0.537000													8	17					0	0	0.003080	0	0
DNAH1	25981	broad.mit.edu	37	3	52384571	52384571	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:52384571C>T	ENST00000420323.2	+	16	2955	c.2694C>T	c.(2692-2694)ttC>ttT	p.F898F		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	898	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		TGGATGAATTCCTCTACAACC	0.557000													10	15					0	0	0.001855	0	0
TM6SF2	53345	broad.mit.edu	37	19	19377355	19377355	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:19377355G>A	ENST00000389363.4	-	9	940	c.868C>T	c.(868-870)Cct>Tct	p.P290S	AC138430.4_ENST00000586064.2_RNA	NM_001001524.2	NP_001001524.2	Q9BZW4	TM6S2_HUMAN	transmembrane 6 superfamily member 2	290						integral to membrane				breast(2)|kidney(1)|large_intestine(1)|lung(8)|skin(1)|upper_aerodigestive_tract(1)	14			Epithelial(12;0.0151)			GAGCAACCAGGGAAGGTGAGA	0.612000													21	25					0	0	0.001216	0	0
PCDHA12	56137	broad.mit.edu	37	5	140256034	140256034	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140256034G>A	ENST00000398631.2	+	1	977	c.977G>A	c.(976-978)gGg>gAg	p.G326E	PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018903.2|NM_031864.1	NP_061726.1|NP_114070.1														NS(4)|breast(2)|cervix(1)|endometrium(19)|kidney(8)|large_intestine(8)|liver(2)|lung(25)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(1)	78			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTGATAAAGGGATTCCTTCC	0.418000													48	65					0	0	0.003610	0	0
KRT8	3856	broad.mit.edu	37	12	53291216	53291216	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:53291216T>A	ENST00000552551.1	-	9	1880	c.1448A>T	c.(1447-1449)aAg>aTg	p.K483M	KRT8_ENST00000293308.6_Missense_Mutation_p.K483M|KRT8_ENST00000552150.1_Missense_Mutation_p.K511M|KRT8_ENST00000546897.1_Missense_Mutation_p.K483M			P05787	K2C8_HUMAN	keratin 8	483	Tail.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			endometrium(5)|large_intestine(1)|liver(1)|lung(3)|ovary(1)|prostate(1)|skin(1)	13				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGCTGTTCACTTGGGCAGGAC	0.637000													15	41					0	0	0.006122	0	0
TRIM65	201292	broad.mit.edu	37	17	73888544	73888544	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:73888544T>C	ENST00000269383.3	-	3	613	c.548A>G	c.(547-549)aAg>aGg	p.K183R		NM_001256124.1|NM_173547.3	NP_001243053.1|NP_775818.2	Q6PJ69	TRI65_HUMAN	tripartite motif containing 65	183						intracellular	zinc ion binding			endometrium(1)|kidney(1)|lung(5)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	12			Epithelial(20;7.53e-06)|all cancers(21;9.11e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			GCTGCTGAACTTGCCGGAGAC	0.642000													44	21					0	0	0.003610	0	0
DENND4B	9909	broad.mit.edu	37	1	153906615	153906615	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:153906615G>A	ENST00000361217.4	-	19	3355	c.2937C>T	c.(2935-2937)gcC>gcT	p.A979A		NM_014856.2	NP_055671.2	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	979										NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			ACTCACTGTGGGCCACACCGG	0.637000													3	12					0	0	0.004672	0	0
MAP3K13	9175	broad.mit.edu	37	3	185161269	185161269	+	Silent	SNP	C	C	T	rs138574503		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:185161269C>T	ENST00000265026.3	+	4	1030	c.696C>T	c.(694-696)atC>atT	p.I232I	MAP3K13_ENST00000446828.1_Silent_p.I25I|MAP3K13_ENST00000443863.1_Silent_p.I88I|MAP3K13_ENST00000535426.1_Silent_p.I88I|MAP3K13_ENST00000424227.1_Silent_p.I232I	NM_004721.4	NP_004712.1	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase 13	232	Protein kinase.			CII -> YLY (in Ref. 6; CAA80915).	activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			NS(1)|biliary_tract(1)|breast(3)|endometrium(3)|kidney(1)|large_intestine(13)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	54	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			ATTGTATTATCATGGAATACT	0.408000													26	70					0	0	0.006320	0	0
SUCO	51430	broad.mit.edu	37	1	172501872	172501872	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:172501872G>A	ENST00000367723.3	+	1	384	c.260G>A	c.(259-261)cGa>cAa	p.R87Q		NM_016227.2	NP_057311.2			SUN domain containing ossification factor																		AGAGAAAAACGAATTCTGGAA	0.517000													15	48					0	0	0.002450	0	0
GPATCH1	55094	broad.mit.edu	37	19	33600768	33600768	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:33600768C>T	ENST00000170564.2	+	11	1745	c.1431C>T	c.(1429-1431)tcC>tcT	p.S477S		NM_018025.2	NP_060495.2	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	477						catalytic step 2 spliceosome	nucleic acid binding			breast(4)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(15)|prostate(4)|skin(4)	40	Esophageal squamous(110;0.137)					CCCAGCTCTCCCCTGCAGCGG	0.567000													17	188					0	0	0.004007	0	0
ACOX3	8310	broad.mit.edu	37	4	8401291	8401291	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:8401291G>A	ENST00000356406.5	-	8	942	c.865C>T	c.(865-867)Ccc>Tcc	p.P289S	ACOX3_ENST00000413009.2_Missense_Mutation_p.P289S|ACOX3_ENST00000503233.1_Missense_Mutation_p.P289S	NM_003501.2	NP_003492.2	O15254	ACOX3_HUMAN	acyl-CoA oxidase 3, pristanoyl	289					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(17)|prostate(1)|skin(3)|stomach(1)	42						ACCTTAAAGGGGCTGACATAG	0.622000													19	105					0	0	0.001216	0	0
MROH7	374977	broad.mit.edu	37	1	55139793	55139793	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:55139793C>T	ENST00000414150.2	+	10	2183	c.1905C>T	c.(1903-1905)atC>atT	p.I635I	MROH7_ENST00000421030.2_Silent_p.I635I|MROH7_ENST00000454855.2_Silent_p.I153I|MROH7_ENST00000545244.1_Silent_p.I203I|MROH7_ENST00000395690.2_Silent_p.I635I|MROH7_ENST00000409996.1_Silent_p.I203I|MROH7_ENST00000339553.5_Silent_p.I635I					maestro heat-like repeat family member 7																		ACGGCATCATCATCCTCTACA	0.512000													26	55					0	0	0.006320	0	0
HIRA	7290	broad.mit.edu	37	22	19384456	19384456	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:19384456G>A	ENST00000263208.5	-	7	764	c.508C>T	c.(508-510)Ctg>Ttg	p.L170L	HIRA_ENST00000340170.4_Silent_p.L170L|HIRA_ENST00000541063.1_Silent_p.L126L|HIRA_ENST00000546308.1_Silent_p.L126L	NM_003325.3	NP_003316.3	P54198	HIRA_HUMAN	histone cell cycle regulator	170					chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)|prostate(1)|skin(1)	37	Colorectal(54;0.0993)					TGACCTCTCAGAGTAGCTAGA	0.478000													17	77					0	0	0.007413	0	0
SLFN13	146857	broad.mit.edu	37	17	33772396	33772396	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:33772396C>T	ENST00000285013.6	-	3	579	c.304G>A	c.(304-306)Gga>Aga	p.G102R	SLFN13_ENST00000360502.2_Intron|SLFN13_ENST00000534689.1_Intron|SLFN13_ENST00000526861.1_Missense_Mutation_p.G102R|SLFN13_ENST00000542635.1_Missense_Mutation_p.G102R|SLFN13_ENST00000533791.1_Missense_Mutation_p.G102R	NM_144682.5	NP_653283.3	Q68D06	SLN13_HUMAN	schlafen family member 13	102						intracellular	ATP binding			NS(1)|breast(1)|endometrium(1)|large_intestine(10)|lung(8)|ovary(3)|pancreas(1)|prostate(5)|stomach(1)	31				UCEC - Uterine corpus endometrioid carcinoma (308;0.0185)		AAACACCTTCCGTGTTGCTTA	0.388000													21	27					0	0	0.001882	0	0
PRF1	5551	broad.mit.edu	37	10	72360558	72360558	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:72360558C>T	ENST00000441259.1	-	2	261	c.101G>A	c.(100-102)aGc>aAc	p.S34N	PRF1_ENST00000373209.2_Missense_Mutation_p.S34N	NM_001083116.1|NM_005041.4	NP_001076585.1|NP_005032.2	P14222	PERF_HUMAN	perforin 1 (pore forming protein)	34	MACPF.				apoptosis|cellular defense response|cytolysis|defense response to tumor cell|defense response to virus|immune response to tumor cell|protein homooligomerization	cytolytic granule|endosome lumen|extracellular region|integral to membrane|plasma membrane	calcium ion binding|protein binding|wide pore channel activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(3)|urinary_tract(3)	23						GAACTTGTGGCTGCGCTTGCA	0.677000			M			"""various leukaemia, lymphoma"""	Type 2 familial hemophagocytic lymphohistiocytosis		Familial Hemophagocytic Lymphohistiocytosis				8	13					0	0	0.003080	0	0
CCNJL	79616	broad.mit.edu	37	5	159680613	159680613	+	Silent	SNP	G	G	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:159680613G>T	ENST00000393977.3	-	7	1365	c.1080C>A	c.(1078-1080)tcC>tcA	p.S360S	CCNJL_ENST00000377503.2_5'UTR|CCNJL_ENST00000257536.7_Silent_p.S312S	NM_024565.5	NP_078841.3	Q8IV13	CCNJL_HUMAN	cyclin J-like	360						nucleus				endometrium(2)|kidney(5)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	17	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			GGGCCTGCAAGGAGTCCCGAT	0.657000													19	61					8.04996e-18	1.37545e-17	0.001882	1	0
CFAP54	144535	broad.mit.edu	37	12	97073495	97073495	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:97073495G>A	ENST00000524981.3	+	7	1034	c.1034G>A	c.(1033-1035)aGa>aAa	p.R345K				Q6ZTY8	CL063_HUMAN		319										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						CGACACAGCAGAAAGTTGCTT	0.453000													34	94					0	0	0.005524	0	0
FAM179A	165186	broad.mit.edu	37	2	29221100	29221100	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:29221100C>T	ENST00000379558.4	+	3	471	c.120C>T	c.(118-120)tcC>tcT	p.S40S	FAM179A_ENST00000403861.2_Silent_p.S40S	NM_199280.2	NP_954974.2	Q6ZUX3	F179A_HUMAN	family with sequence similarity 179, member A	40							binding			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(5)|lung(9)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	26						GCATCAACTCCAGTCTGCCTC	0.652000													4	20					0	0	0.001168	0	0
COL1A2	1278	broad.mit.edu	37	7	94051224	94051224	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:94051224T>G	ENST00000297268.6	+	39	2834	c.2363T>G	c.(2362-2364)tTc>tGc	p.F788C		NM_000089.3	NP_000080.2	P08123	CO1A2_HUMAN	collagen, type I, alpha 2	788			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	NS(2)|breast(2)|central_nervous_system(4)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(21)|lung(51)|ovary(2)|prostate(1)|skin(7)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	115	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	ATGACTGGTTTCCCTGGTGCT	0.448000										HNSCC(75;0.22)			11	28					0	0	0.001368	0	0
GPR179	440435	broad.mit.edu	37	17	36487299	36487299	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:36487299G>A	ENST00000342292.4	-	11	2173	c.2153C>T	c.(2152-2154)tCc>tTc	p.S718F		NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	718						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CCTCATGAAGGAGCGGCCCAG	0.657000													22	8					0	0	0.001882	0	0
KIF13A	63971	broad.mit.edu	37	6	17837260	17837260	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:17837260T>C	ENST00000378814.5	-	11	1003	c.1004A>G	c.(1003-1005)aAc>aGc	p.N335S	KIF13A_ENST00000378816.5_Missense_Mutation_p.N335S|KIF13A_ENST00000378826.2_Missense_Mutation_p.N335S|KIF13A_ENST00000378843.2_Missense_Mutation_p.N335S|KIF13A_ENST00000259711.6_Missense_Mutation_p.N335S	NM_001105568.2	NP_001099038.1	Q9H1H9	KI13A_HUMAN	kinesin family member 13A	335					cargo loading into vesicle|cell cycle|cytokinesis|endosome to lysosome transport|Golgi to plasma membrane protein transport|melanosome organization|plus-end-directed vesicle transport along microtubule	centrosome|endosome membrane|microtubule|midbody|trans-Golgi network membrane	ATP binding|microtubule motor activity|protein binding			breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	64	Breast(50;0.0107)|Ovarian(93;0.016)	all_hematologic(90;0.125)	all cancers(50;0.0865)|Epithelial(50;0.0974)			CTCTTCATAGTTGTCTGCGGC	0.488000													72	260					0	0	0.003610	0	0
ASAH2	56624	broad.mit.edu	37	10	52008332	52008332	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:52008332C>T	ENST00000395526.3	-	1	38	c.39G>A	c.(37-39)ctG>ctA	p.L13L	ASAH2_ENST00000447815.1_Silent_p.L13L	NM_019893.2	NP_063946.2	Q9NR71	ASAH2_HUMAN	N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2	13					apoptosis|ceramide metabolic process|signal transduction	integral to membrane|mitochondrion|plasma membrane	ceramidase activity			large_intestine(1)|lung(9)|urinary_tract(1)	11						GGAGGAAAATCAGGAATGTCT	0.433000													14	25					0	0	0.003163	0	0
TAF4	6874	broad.mit.edu	37	20	60578892	60578892	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:60578892G>A	ENST00000252996.3	-	8	2265	c.2266C>T	c.(2266-2268)Ccg>Tcg	p.P756S	TAF4_ENST00000488539.1_5'UTR	NM_003185.3	NP_003176.2	O00268	TAF4_HUMAN	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa	756					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(2)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			GTCACCTGCGGGGGCCGGATC	0.652000													13	26					0	0	0.006122	0	0
MUC16	94025	broad.mit.edu	37	19	9086712	9086712	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9086712G>A	ENST00000397910.4	-	1	5306	c.5103C>T	c.(5101-5103)tcC>tcT	p.S1701S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1701	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAAGGACAGAGGAAACTCTTC	0.488000													53	66					0	0	0.003610	0	0
NBR1	4077	broad.mit.edu	37	17	41341698	41341698	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:41341698C>T	ENST00000422280.1	+	8	1033	c.574C>T	c.(574-576)Ccc>Tcc	p.P192S	NBR1_ENST00000589872.1_Missense_Mutation_p.P192S|NBR1_ENST00000389312.4_Missense_Mutation_p.P192S|NBR1_ENST00000341165.6_Missense_Mutation_p.P192S|NBR1_ENST00000590996.1_Missense_Mutation_p.P192S|NBR1_ENST00000542611.1_Missense_Mutation_p.P171S	NM_031858.2	NP_114064.1	Q14596	NBR1_HUMAN	neighbor of BRCA1 gene 1	192					macroautophagy|protein oligomerization	autophagic vacuole|cytoplasmic vesicle|cytosol|late endosome|lysosome|sarcomere	ubiquitin binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	24		Breast(137;0.00086)		BRCA - Breast invasive adenocarcinoma(366;0.0934)		GGGTTCTTGTCCCTCAGAAGT	0.418000													44	115					0	0	0.002852	0	0
RGS7BP	401190	broad.mit.edu	37	5	63905011	63905011	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:63905011A>G	ENST00000334025.2	+	6	1032	c.706A>G	c.(706-708)Act>Gct	p.T236A		NM_001029875.1|NM_001271890.1|NM_001271891.1	NP_001025046.1|NP_001258819.1|NP_001258820.1	Q6MZT1	R7BP_HUMAN	regulator of G-protein signaling 7 binding protein	236					negative regulation of signal transduction	cytoplasm|nucleus|plasma membrane				breast(1)|large_intestine(4)|lung(3)|prostate(1)|skin(1)|stomach(1)	11		Lung NSC(810;0.000518)|Prostate(74;0.0435)|Ovarian(174;0.186)		Lung(70;0.147)		TCTGAATCTAACTCCCTACCC	0.468000													31	25					0	0	0.004289	0	0
DAGLA	747	broad.mit.edu	37	11	61507082	61507082	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:61507082C>A	ENST00000257215.5	+	17	1918	c.1802C>A	c.(1801-1803)cCg>cAg	p.P601Q		NM_006133.2	NP_006124.1	Q9Y4D2	DGLA_HUMAN	diacylglycerol lipase, alpha	601					cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|liver(2)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(4)	43				READ - Rectum adenocarcinoma(4;0.219)		CCACTCTACCCGCCCGGCCGC	0.657000													9	23					3.86212e-05	6.5478e-05	0.000673	1	0
PRRT1	80863	broad.mit.edu	37	6	32118479	32118479	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32118479G>A	ENST00000211413.5	-	2	348	c.224C>T	c.(223-225)cCc>cTc	p.P75L	PRRT1_ENST00000375152.2_Intron|PRRT1_ENST00000375150.2_Intron	NM_030651.3	NP_085154.3	Q99946	PRRT1_HUMAN	proline-rich transmembrane protein 1	75					response to biotic stimulus	integral to membrane				breast(2)|endometrium(1)|kidney(1)|lung(2)	6						AGAGGAGGAGGGACCGCGCTG	0.746000													14	143					0	0	0.002450	0	0
AFAP1	60312	broad.mit.edu	37	4	7844898	7844898	+	Silent	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:7844898A>G	ENST00000420658.1	-	5	786	c.514T>C	c.(514-516)Ttg>Ctg	p.L172L	AFAP1_ENST00000358461.2_Silent_p.L172L|AFAP1_ENST00000382543.3_Silent_p.L172L|AFAP1_ENST00000360265.4_Silent_p.L172L	NM_001134647.1	NP_001128119.1	Q8N556	AFAP1_HUMAN	actin filament associated protein 1	172	PH 1.					actin cytoskeleton|cytoplasm|focal adhesion	actin binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|skin(4)|stomach(2)	32						ACGCAGAGCAACTTGGTCCAC	0.532000													27	138					0	0	0.001512	0	0
LPHN3	23284	broad.mit.edu	37	4	62935951	62935951	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:62935951C>T	ENST00000514591.1	+	25	4064	c.3735C>T	c.(3733-3735)gaC>gaT	p.D1245D	LPHN3_ENST00000509896.1_3'UTR|LPHN3_ENST00000511324.1_3'UTR|LPHN3_ENST00000508693.1_3'UTR|LPHN3_ENST00000506746.1_Silent_p.D1347D|LPHN3_ENST00000545650.1_Silent_p.D1245D|LPHN3_ENST00000507164.1_3'UTR|LPHN3_ENST00000506720.1_Silent_p.D1356D|LPHN3_ENST00000514996.1_Silent_p.D1279D|LPHN3_ENST00000514157.1_3'UTR|LPHN3_ENST00000508946.1_Silent_p.D1288D|LPHN3_ENST00000506700.1_3'UTR|LPHN3_ENST00000512091.1_3'UTR|LPHN3_ENST00000507625.1_Silent_p.D1304D|LPHN3_ENST00000504896.1_3'UTR			Q9HAR2	LPHN3_HUMAN	latrophilin 3	1223					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						AAATCATAGACCGTGGCTATA	0.453000													7	27					0	0	0.001984	0	0
CSMD2	114784	broad.mit.edu	37	1	34192243	34192243	+	Silent	SNP	G	G	A	rs140431671		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:34192243G>A	ENST00000373381.4	-	16	2588	c.2412C>T	c.(2410-2412)ctC>ctT	p.L804L		NM_052896.3	NP_443128.2	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	764	CUB 5.					integral to membrane|plasma membrane	protein binding			NS(5)|breast(5)|central_nervous_system(3)|cervix(2)|endometrium(20)|haematopoietic_and_lymphoid_tissue(4)|kidney(9)|large_intestine(43)|lung(114)|ovary(8)|pancreas(1)|prostate(6)|skin(20)|upper_aerodigestive_tract(5)|urinary_tract(1)	246		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				AGCCCGGAGAGAGGATGGTGC	0.577000													14	39					0	0	0.002450	0	0
AWAT2	158835	broad.mit.edu	37	X	69262176	69262176	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:69262176G>A	ENST00000276101.3	-	6	713	c.708C>T	c.(706-708)ttC>ttT	p.F236F		NM_001002254.1	NP_001002254.1	Q6E213	AWAT2_HUMAN	acyl-CoA wax alcohol acyltransferase 2	236						endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity			endometrium(3)|large_intestine(3)|lung(2)|ovary(1)	9						CACCAGGAGTGAAAATGTGCT	0.498000													15	5					0	0	0.004990	0	0
FBN3	84467	broad.mit.edu	37	19	8156470	8156470	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:8156470G>A	ENST00000600128.1	-	48	6324	c.5910C>T	c.(5908-5910)atC>atT	p.I1970I	FBN3_ENST00000270509.2_Silent_p.I1970I|FBN3_ENST00000601739.1_Silent_p.I1970I			Q75N90	FBN3_HUMAN	fibrillin 3	1970	EGF-like 32; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent	p.I1970I(2)		NS(1)|breast(9)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(15)|lung(53)|ovary(7)|pancreas(2)|prostate(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	132						AGCACTCGTCGATATCTGGAA	0.602000													21	22					0	0	0.002299	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133661478	133661478	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:133661478G>A	ENST00000310926.4	-	11	1869	c.1596C>T	c.(1594-1596)tcC>tcT	p.S532S	SLCO2A1_ENST00000493729.1_Silent_p.S456S	NM_005630.2	NP_005621.2	Q92959	SO2A1_HUMAN	solute carrier organic anion transporter family, member 2A1	532					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						GGGGGTTGTGGGAGATGCAGG	0.587000													17	35					0	0	0.004990	0	0
GABRG2	2566	broad.mit.edu	37	5	161580318	161580318	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:161580318C>T	ENST00000356592.3	+	10	1832	c.1372C>T	c.(1372-1374)Ccc>Tcc	p.P458S	GABRG2_ENST00000393933.4_Missense_Mutation_p.P355S|GABRG2_ENST00000414552.2_Missense_Mutation_p.P498S|GABRG2_ENST00000361925.4_Missense_Mutation_p.P450S	NM_000816.3|NM_198904.2	NP_000807.2|NP_944494.1	P18507	GBRG2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 2	450					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(15)|lung(24)|ovary(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	62	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		GATCTTCTTCCCCACTGCCTT	0.453000													100	155					0	0	0.003610	0	0
CYP3A5	1577	broad.mit.edu	37	7	99247856	99247856	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:99247856C>T	ENST00000339843.2	-	12	2959		c.e12-1		CYP3A5_ENST00000222982.4_Splice_Site|CYP3A5_ENST00000343703.5_Splice_Site					cytochrome P450, family 3, subfamily A, polypeptide 5											NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	all_epithelial(64;2.77e-08)|Lung NSC(181;0.00396)|all_lung(186;0.00659)|Esophageal squamous(72;0.0166)					CTTACTGAACCTAGTTCCATA	0.408000													32	54					0	0	0.002836	0	0
RANGAP1	5905	broad.mit.edu	37	22	41648895	41648895	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:41648895G>A	ENST00000455915.2	-	11	2830	c.1361C>T	c.(1360-1362)tCc>tTc	p.S454F	RANGAP1_ENST00000407260.4_Missense_Mutation_p.S399F|RANGAP1_ENST00000405486.1_Missense_Mutation_p.S454F|RANGAP1_ENST00000356244.3_Missense_Mutation_p.S454F			P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	454					mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						TATCAGCACGGAGCTCTTGGG	0.607000													19	50					0	0	0.001216	0	0
WNT8A	7478	broad.mit.edu	37	5	137426466	137426466	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:137426466G>A	ENST00000506684.1	+	5	1050	c.814G>A	c.(814-816)Gaa>Aaa	p.E272K	WNT8A_ENST00000398754.1_Missense_Mutation_p.E254K			Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family, member 8A	254					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|skin(2)	18			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CTTTTTAGAGGAATCACCAGA	0.582000													37	56					0	0	0.006999	0	0
RP1	6101	broad.mit.edu	37	8	55541479	55541479	+	Silent	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:55541479A>G	ENST00000220676.1	+	4	5185	c.5037A>G	c.(5035-5037)tcA>tcG	p.S1679S		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	1679					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			AAGGGCAGTCATTTGGCTCTT	0.413000													90	117					0	0	0.003610	0	0
RIMS2	9699	broad.mit.edu	37	8	104898211	104898211	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:104898211C>T	ENST00000507740.1	+	2	1044	c.808C>T	c.(808-810)Cct>Tct	p.P270S	RIMS2_ENST00000262231.10_Missense_Mutation_p.P270S|RIMS2_ENST00000406091.3_Missense_Mutation_p.P462S|RIMS2_ENST00000436393.2_Missense_Mutation_p.P240S	NM_014677.4	NP_055492.3	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	493					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			NS(1)|breast(4)|central_nervous_system(5)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(22)|liver(1)|lung(68)|ovary(6)|pancreas(2)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(10)|urinary_tract(1)	144			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			CCACTTAGATCCTAGCTCTGC	0.468000										HNSCC(12;0.0054)			22	81					0	0	0.001882	0	0
SCP2D1	140856	broad.mit.edu	37	20	18794854	18794854	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:18794854G>A	ENST00000377428.2	+	1	485	c.395G>A	c.(394-396)gGa>gAa	p.G132E	C20orf78_ENST00000278779.4_Intron	NM_178483.2	NP_848578.1			SCP2 sterol-binding domain containing 1																		TTCCTTGCCGGAAAGTTCAAA	0.473000													17	66					0	0	0.002299	0	0
SEL1L2	80343	broad.mit.edu	37	20	13850798	13850798	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:13850798C>T	ENST00000284951.5	-	13	1230	c.1156G>A	c.(1156-1158)Gga>Aga	p.G386R	SEL1L2_ENST00000486903.1_5'UTR|SEL1L2_ENST00000378072.5_Missense_Mutation_p.G386R			Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 (C. elegans)	386						integral to membrane	binding			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	51						AGGGGAACTCCTTTTCCATGA	0.333000													26	116					0	0	0.004656	0	0
NAV3	89795	broad.mit.edu	37	12	78513382	78513382	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:78513382C>T	ENST00000397909.2	+	15	3579	c.3406C>T	c.(3406-3408)Cgc>Tgc	p.R1136C	NAV3_ENST00000228327.6_Missense_Mutation_p.R1136C|NAV3_ENST00000536525.2_Missense_Mutation_p.R1136C|NAV3_ENST00000266692.7_Missense_Mutation_p.R1136C			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1136	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CCTACAATATCGCAGCTTGCC	0.512000										HNSCC(70;0.22)			13	51					0	0	0.001368	0	0
HDAC7	51564	broad.mit.edu	37	12	48191223	48191223	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:48191223G>A	ENST00000080059.7	-	6	520	c.521C>T	c.(520-522)cCt>cTt	p.P174L	HDAC7_ENST00000380610.4_Missense_Mutation_p.P191L|HDAC7_ENST00000427332.2_Missense_Mutation_p.P135L|HDAC7_ENST00000354334.3_Missense_Mutation_p.P174L|HDAC7_ENST00000552960.1_Missense_Mutation_p.P157L	NM_015401.3	NP_056216.2	Q8WUI4	HDAC7_HUMAN	histone deacetylase 7	135	Transcription repression 1 (By similarity).				negative regulation of interleukin-2 production|negative regulation of osteoblast differentiation|positive regulation of cell migration involved in sprouting angiogenesis|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	activating transcription factor binding|histone deacetylase activity (H3-K16 specific)|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein kinase C binding|repressing transcription factor binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	25				GBM - Glioblastoma multiforme(48;0.137)		GGGAACAGGAGGCAAAAAGCT	0.612000													29	72					0	0	0.002096	0	0
LARS	51520	broad.mit.edu	37	5	145500056	145500056	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:145500056G>A	ENST00000394434.2	-	31	3369	c.3203C>T	c.(3202-3204)tCc>tTc	p.S1068F	LARS_ENST00000545646.1_Missense_Mutation_p.S1022F|LARS_ENST00000510191.1_Missense_Mutation_p.S1014F|LARS_ENST00000274562.9_Missense_Mutation_p.S1041F	NM_020117.9	NP_064502.9	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	1068					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding			breast(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|prostate(1)|skin(2)|stomach(8)	34			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	CAGAGAAACGGACACACCAGG	0.428000													39	48					0	0	0.007835	0	0
ZC3H4	23211	broad.mit.edu	37	19	47570693	47570693	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:47570693G>A	ENST00000253048.5	-	15	2869	c.2832C>T	c.(2830-2832)ctC>ctT	p.L944L	ZC3H4_ENST00000594019.1_Intron	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	944							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GGTGCCCGGGGAGTGGGTCCA	0.687000													42	66					0	0	0.003610	0	0
TSPAN8	7103	broad.mit.edu	37	12	71519129	71519129	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:71519129C>T	ENST00000393330.2	-	12	1251	c.699G>A	c.(697-699)caG>caA	p.Q233Q	TSPAN8_ENST00000247829.3_Silent_p.Q233Q|TSPAN8_ENST00000552128.1_Silent_p.Q150Q|TSPAN8_ENST00000546561.1_Silent_p.Q233Q			P19075	TSN8_HUMAN	tetraspanin 8	233					protein glycosylation	integral to membrane|lysosome	signal transducer activity	p.Q233H(1)		breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(3)|lung(7)|skin(3)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			TGTTCCCGATCTGGCAATACA	0.353000													96	238					0	0	0.003610	0	0
LOC541473	541473	broad.mit.edu	37	7	75023525	75023525	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:75023525C>T	ENST00000275590.5	-	0	418				STAG3L1_ENST00000402225.5_RNA	NR_003602.2																						TTCTCCAGCTCCTACTCTGAA	0.468000													14	13					0	0	0.004007	0	0
PPP1R2P1	100507444	broad.mit.edu	37	6	32847367	32847367	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32847367C>T	ENST00000420261.1	-	0	258																											GCATCTTCATCATCACCCATC	0.428000													8	40					0	0	0.003080	0	0
NLRP11	204801	broad.mit.edu	37	19	56303677	56303677	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:56303677C>T	ENST00000443188.1	-	9	3213	c.2503G>A	c.(2503-2505)Gag>Aag	p.E835K	NLRP11_ENST00000592953.1_Missense_Mutation_p.E736K|NLRP11_ENST00000360133.3_Missense_Mutation_p.E781K|NLRP11_ENST00000589824.2_Missense_Mutation_p.E781K|NLRP11_ENST00000589093.1_Missense_Mutation_p.E835K	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	835							ATP binding	p.E835Q(1)		NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		TGAAGCTCCTCTAACTGACAG	0.488000													30	87					0	0	0.004878	0	0
C4B	721	broad.mit.edu	37	6	31997536	31997536	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31997536C>T	ENST00000435363.2	+	29	3954	c.3870C>T	c.(3868-3870)acC>acT	p.T1290T	C4B_ENST00000425700.2_Silent_p.T1290T	NM_001002029.3	NP_001002029.3	P0C0L5	CO4B_HUMAN	complement component 4B (Chido blood group)	1290					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity										CCTGGCTCACCCGTCAGGGCA	0.652000													13	194					0	0	0.002450	0	0
UHRF1BP1	54887	broad.mit.edu	37	6	34823398	34823398	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:34823398C>T	ENST00000192788.5	+	9	1209	c.1038C>T	c.(1036-1038)gtC>gtT	p.V346V	UHRF1BP1_ENST00000452449.2_Silent_p.V346V	NM_017754.3	NP_060224.3	Q6BDS2	URFB1_HUMAN	UHRF1 binding protein 1	346										breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(11)|lung(24)|ovary(3)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	54						TTATAGGTGTCTCTGCCAACA	0.458000													32	143					0	0	0.003755	0	0
SNTB2	6645	broad.mit.edu	37	16	69334793	69334793	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:69334793C>T	ENST00000336278.4	+	7	1627	c.1589C>T	c.(1588-1590)tCg>tTg	p.S530L	VPS4A_ENST00000569775.1_Intron|RP11-343C2.3_ENST00000570054.2_Intron	NM_006750.3	NP_006741.1	Q13425	SNTB2_HUMAN	syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)	530	Calmodulin-binding (By similarity).|SU.					cell junction|dystrophin-associated glycoprotein complex|membrane fraction|microtubule|transport vesicle membrane	actin binding|calmodulin binding|protein binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	13		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.208)		ACGTTTTTATCGGCCAAAGTC	0.418000													22	50					0	0	0.001882	0	0
LRFN2	57497	broad.mit.edu	37	6	40400382	40400382	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:40400382G>A	ENST00000338305.6	-	2	1013	c.471C>T	c.(469-471)tcC>tcT	p.S157S		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	157						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					GGTTGTTGTAGGAGAGGTCCA	0.582000													20	86					0	0	0.007413	0	0
MYO5B	4645	broad.mit.edu	37	18	47500984	47500984	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:47500984G>A	ENST00000285039.7	-	10	1357	c.1056_splice	c.e10-1	p.P353_splice		NM_001080467.2	NP_001073936.1	Q9ULV0	MYO5B_HUMAN	myosin VB	353	Myosin head-like.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(6)|lung(29)|ovary(3)|pancreas(1)|prostate(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(4)	87				READ - Rectum adenocarcinoma(32;0.103)		TACATCCTGGGGCTGTGGGAG	0.587000													20	31					0	0	0.001882	0	0
ZNF443	10224	broad.mit.edu	37	19	12541577	12541577	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:12541577G>A	ENST00000301547.5	-	4	1606	c.1409C>T	c.(1408-1410)aCt>aTt	p.T470I	CTD-3105H18.16_ENST00000595562.1_Intron	NM_005815.4	NP_005806.2	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	470					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|pancreas(1)|prostate(1)	28						TCCAGTATGAGTTGTTTCATG	0.408000													19	24					0	0	0.005443	0	0
PGP	283871	broad.mit.edu	37	16	2263819	2263819	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:2263819A>C	ENST00000333503.7	-	2	905	c.876T>G	c.(874-876)aaT>aaG	p.N292K		NM_001042371.2	NP_001035830.1	A6NDG6	PGP_HUMAN	phosphoglycolate phosphatase	292					carbohydrate metabolic process		phosphoglycolate phosphatase activity			skin(1)	1						CACTTTCCTGATTATTCTTCA	0.517000													19	62					0	0	0.007413	0	0
NWD1	284434	broad.mit.edu	37	19	16875870	16875870	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:16875870G>A	ENST00000524140.2	+	10	2695	c.2277G>A	c.(2275-2277)cgG>cgA	p.R759R	NWD1_ENST00000523826.1_Silent_p.R553R|NWD1_ENST00000379808.3_Silent_p.R759R|NWD1_ENST00000339803.6_Silent_p.R624R|NWD1_ENST00000552788.1_Silent_p.R759R|NWD1_ENST00000549814.1_Silent_p.R759R	NM_001007525.3	NP_001007526.3	Q149M9	NWD1_HUMAN	NACHT and WD repeat domain containing 1	759							ATP binding			NS(3)|breast(2)|cervix(1)|endometrium(8)|large_intestine(17)|lung(18)|ovary(2)|pancreas(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	67						TTTCCTGCCGGGGCATCTCTG	0.607000													19	14					0	0	0.002780	0	0
AEN	64782	broad.mit.edu	37	15	89169881	89169881	+	Silent	SNP	C	C	T	rs35195058	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:89169881C>T	ENST00000332810.3	+	2	592	c.441C>T	c.(439-441)atC>atT	p.I147I	AEN_ENST00000379231.3_Silent_p.I147I	NM_022767.3	NP_073604.3	Q8WTP8	AEN_HUMAN	apoptosis enhancing nuclease	147	Exonuclease.				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|response to ionizing radiation	nucleolus|nucleoplasm	exonuclease activity|nucleic acid binding			NS(1)|kidney(1)|large_intestine(1)|lung(4)	7						ACAAGTACATCAGGCCTGAGA	0.607000													29	32					0	0	0.006320	0	0
ZNF443	10224	broad.mit.edu	37	19	12541578	12541578	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:12541578T>A	ENST00000301547.5	-	4	1605	c.1408A>T	c.(1408-1410)Act>Tct	p.T470S	CTD-3105H18.16_ENST00000595562.1_Intron	NM_005815.4	NP_005806.2	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	470					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|pancreas(1)|prostate(1)	28						CCAGTATGAGTTGTTTCATGC	0.408000													19	23					0	0	0.005443	0	0
ZNF37BP	100129482	broad.mit.edu	37	10	43016537	43016537	+	RNA	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:43016537A>G	ENST00000473592.1	-	0	2662																											AACTCATTGAACTTCATTCTT	0.313000													22	42					0	0	0.003330	0	0
SPATA20	64847	broad.mit.edu	37	17	48626486	48626486	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:48626486C>T	ENST00000006658.6	+	6	719	c.599C>T	c.(598-600)cCt>cTt	p.P200L	SPATA20_ENST00000356488.4_Missense_Mutation_p.P184L|SPATA20_ENST00000393244.3_Missense_Mutation_p.P140L|SPATA20_ENST00000511937.1_3'UTR	NM_022827.3	NP_073738.2	Q8TB22	SPT20_HUMAN	spermatogenesis associated 20	184					cell differentiation|mannose metabolic process|multicellular organismal development|spermatogenesis	extracellular region	mannose-6-phosphate isomerase activity|protein binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(9)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	24	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;9.38e-09)			ACCTATTTCCCTCCTGAGGAT	0.652000													14	40					0	0	0.002450	0	0
FAM117B	150864	broad.mit.edu	37	2	203622041	203622041	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:203622041A>C	ENST00000303116.6	+	6	1220	c.478A>C	c.(478-480)Agc>Cgc	p.S160R	FAM117B_ENST00000392238.2_Missense_Mutation_p.S404R	NM_173511.3	NP_775782.2	Q6P1L5	F117B_HUMAN	family with sequence similarity 117, member B	404										breast(3)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(5)|ovary(1)	17						AGACAGGGGAAGCAACAACAG	0.572000													124	188					0	0	0.003610	0	0
DSP	1832	broad.mit.edu	37	6	7580387	7580387	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:7580387G>A	ENST00000379802.3	+	23	4305	c.3964G>A	c.(3964-3966)Gac>Aac	p.D1322N	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1322	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GACCATTCAGGACAAAAATAA	0.502000													21	120					0	0	0.001882	0	0
SLC30A8	169026	broad.mit.edu	37	8	118184920	118184920	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:118184920G>A	ENST00000427715.2	+	11	1397	c.963G>A	c.(961-963)taG>taA	p.*321*	SLC30A8_ENST00000519688.1_Silent_p.*321*|SLC30A8_ENST00000521243.1_Silent_p.*321*|SLC30A8_ENST00000456015.2_Silent_p.*370*	NM_001172813.1|NM_001172815.1	NP_001166284.1|NP_001166286.1	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 (zinc transporter), member 8	0					insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			breast(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(18)|ovary(2)|pancreas(2)|skin(5)	41	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			CCTGTGACTAGCTCAGTCACA	0.463000													83	380					0	0	0.003610	0	0
QTRT1	81890	broad.mit.edu	37	19	10823826	10823826	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:10823826C>T	ENST00000250237.5	+	10	1102	c.1092C>T	c.(1090-1092)atC>atT	p.I364I		NM_031209.2	NP_112486.1	Q9BXR0	TGT_HUMAN	queuine tRNA-ribosyltransferase 1	364					queuosine biosynthetic process	mitochondrion|nucleus|ribosome	metal ion binding|queuine tRNA-ribosyltransferase activity			large_intestine(2)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	12			Epithelial(33;1.55e-05)|all cancers(31;3.42e-05)			GCACCAGCATCGTGGAGAAGC	0.687000													19	29					0	0	0.001216	0	0
CNTN4	152330	broad.mit.edu	37	3	2861197	2861197	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:2861197G>A	ENST00000397461.1	+	6	770	c.386G>A	c.(385-387)aGa>aAa	p.R129K	CNTN4_ENST00000418658.1_Missense_Mutation_p.R129K|CNTN4_ENST00000427331.1_Missense_Mutation_p.R129K	NM_001206955.1	NP_001193884.1	Q8IWV2	CNTN4_HUMAN	contactin 4	129	Ig-like C2-type 2.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(19)|ovary(2)|pancreas(4)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		ACAAGAACAAGAAGCACTGTG	0.413000													15	44					0	0	0.004990	0	0
HTT	3064	broad.mit.edu	37	4	3148619	3148619	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:3148619C>T	ENST00000355072.5	+	25	3384	c.3239C>T	c.(3238-3240)cCa>cTa	p.P1080L		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	1080					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GCTTGGTTCCCATTGGATCTC	0.507000													150	836					0	0	0.003610	0	0
GPR111	222611	broad.mit.edu	37	6	47649845	47649845	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:47649845G>A	ENST00000398742.2	+	5	1395	c.1346G>A	c.(1345-1347)gGa>gAa	p.G449E	GPR111_ENST00000296862.1_Missense_Mutation_p.G517E|GPR111_ENST00000507065.1_Missense_Mutation_p.G449E			Q8IZF7	GP111_HUMAN	G protein-coupled receptor 111	517					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(15)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29						CACCACAAGGGATGTGTGGCA	0.433000													19	60					0	0	0.006122	0	0
DHRS7C	201140	broad.mit.edu	37	17	9694459	9694459	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:9694459C>T	ENST00000330255.4	-	1	155	c.143G>A	c.(142-144)gGa>gAa	p.G48E	DHRS7C_ENST00000571134.1_Missense_Mutation_p.G48E	NM_001220493.1	NP_001207422.1	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	48						extracellular region	binding|oxidoreductase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	15						CTTGCCCAGTCCTGAGATGGC	0.602000													3	4					0	0	0.000248	0	0
TINAGL1	64129	broad.mit.edu	37	1	32048836	32048836	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:32048836A>G	ENST00000271064.7	+	4	537	c.461A>G	c.(460-462)aAc>aGc	p.N154S	TINAGL1_ENST00000537531.1_3'UTR|TINAGL1_ENST00000481165.1_3'UTR|TINAGL1_ENST00000457433.2_Intron	NM_001204415.1|NM_022164.2	NP_001191344.1|NP_071447.1	Q9GZM7	TINAL_HUMAN	tubulointerstitial nephritis antigen-like 1	154					endosome transport|immune response|proteolysis	extracellular region	cysteine-type endopeptidase activity|extracellular matrix structural constituent|polysaccharide binding|scavenger receptor activity			breast(2)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|urinary_tract(1)	18		Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.104)		STAD - Stomach adenocarcinoma(196;0.0526)|READ - Rectum adenocarcinoma(331;0.145)		AACCAGGGCAACTATGGGTGA	0.567000													18	35					0	0	0.007413	0	0
CCKBR	887	broad.mit.edu	37	11	6292162	6292162	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:6292162G>A	ENST00000525462.1	+	4	943	c.940G>A	c.(940-942)Gag>Aag	p.E314K	CCKBR_ENST00000334619.2_Intron|CCKBR_ENST00000532715.1_Intron|CCKBR_ENST00000532396.1_Intron			P32239	GASR_HUMAN	cholecystokinin B receptor	266					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			NS(2)|breast(2)|endometrium(4)|kidney(13)|large_intestine(10)|lung(22)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	GTTGAGCTGGGAGCGGAGGTC	0.637000													4	5					0	0	0.000248	0	0
HSD17B4	3295	broad.mit.edu	37	5	118844910	118844910	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:118844910G>A	ENST00000504811.1	+	17	1667	c.1483G>A	c.(1483-1485)Ggt>Agt	p.G495S	HSD17B4_ENST00000515320.1_Missense_Mutation_p.G452S|HSD17B4_ENST00000513628.1_Missense_Mutation_p.G333S|HSD17B4_ENST00000414835.2_Missense_Mutation_p.G330S|HSD17B4_ENST00000510025.1_Missense_Mutation_p.G446S|HSD17B4_ENST00000256216.6_Missense_Mutation_p.G470S|HSD17B4_ENST00000522415.1_3'UTR|HSD17B4_ENST00000509514.1_Missense_Mutation_p.G208S	NM_001199291.1	NP_001186220.1	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	470	Enoyl-CoA hydratase 2.|MaoC-like.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|pancreas(1)|prostate(2)|urinary_tract(2)	25		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	TGGAGGCTTTGGTGGAAAACG	0.348000													35	147					0	0	0.001951	0	0
TMEM260	54916	broad.mit.edu	37	14	57099832	57099832	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:57099832C>T	ENST00000261556.6	+	13	1789	c.1667C>T	c.(1666-1668)cCt>cTt	p.P556L	TMEM260_ENST00000536419.1_Missense_Mutation_p.P90L|TMEM260_ENST00000538838.1_3'UTR	NM_017799.3	NP_060269.3			transmembrane protein 260																		GTATTCAACCCTGAGGAATGG	0.378000													13	32					0	0	0.004990	0	0
KLHL38	340359	broad.mit.edu	37	8	124659227	124659227	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:124659227A>G	ENST00000325995.7	-	2	1401	c.1378T>C	c.(1378-1380)Ttc>Ctc	p.F460L	CTD-2552K11.2_ENST00000524355.1_RNA	NM_001081675.2	NP_001075144.2	Q2WGJ6	KLH38_HUMAN	kelch-like family member 38	460										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(16)|pancreas(1)|prostate(3)|stomach(1)	38						TCCATTTTGAACCACGAGTTT	0.433000													45	201					0	0	0.003214	0	0
LRRC4B	94030	broad.mit.edu	37	19	51022309	51022309	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:51022309C>T	ENST00000599957.1	-	3	858	c.661G>A	c.(661-663)Gac>Aac	p.D221N	LRRC4B_ENST00000389201.3_Missense_Mutation_p.D221N			Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B	221						cell junction|integral to membrane|presynaptic membrane				breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|liver(1)|lung(11)|prostate(4)|skin(1)|urinary_tract(1)	30		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		TTGGGGATGTCCTTGAGGTTG	0.662000													14	5					0	0	0.002450	0	0
VAT1L	57687	broad.mit.edu	37	16	78005799	78005799	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:78005799T>A	ENST00000302536.2	+	8	1283	c.1130T>A	c.(1129-1131)aTt>aAt	p.I377N		NM_020927.1	NP_065978.1	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport 1-like	377							oxidoreductase activity|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(10)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	24						GGCAAGTTAATTCTGGATGTA	0.527000											OREG0023950	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	69	152					0	0	0.003610	0	0
DNAH8	1769	broad.mit.edu	37	6	38840747	38840747	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:38840747G>A	ENST00000359357.3	+	49	6906	c.6652G>A	c.(6652-6654)Gtt>Att	p.V2218I	DNAH8_ENST00000441566.1_Missense_Mutation_p.V2182I|DNAH8_ENST00000449981.2_Missense_Mutation_p.V2435I					dynein, axonemal, heavy chain 8									p.V2218I(2)		NS(7)|breast(9)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(16)|large_intestine(44)|liver(4)|lung(101)|ovary(7)|pancreas(2)|prostate(8)|skin(28)|stomach(4)|upper_aerodigestive_tract(6)|urinary_tract(4)	260						CTTAAATTCCGTTTTGGATGA	0.383000													30	142					0	0	0.007291	0	0
WDR47	22911	broad.mit.edu	37	1	109525357	109525357	+	Silent	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:109525357A>G	ENST00000357672.3	-	11	2431	c.2056T>C	c.(2056-2058)Ttg>Ctg	p.L686L	WDR47_ENST00000369965.4_Silent_p.L715L|WDR47_ENST00000400794.3_Silent_p.L722L|WDR47_ENST00000369962.3_Silent_p.L714L|WDR47_ENST00000361054.3_Silent_p.L686L			O94967	WDR47_HUMAN	WD repeat domain 47	714										breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	20		all_lung(203;0.00519)|all_epithelial(167;0.00611)|Lung NSC(277;0.00822)		Colorectal(144;0.0165)|Lung(183;0.0484)|COAD - Colon adenocarcinoma(174;0.128)|Epithelial(280;0.168)|all cancers(265;0.201)|LUSC - Lung squamous cell carcinoma(189;0.244)		ATAAATGCCAAGTCTCTAATT	0.388000													167	428					0	0	0.003610	0	0
SLC1A1	6505	broad.mit.edu	37	9	4585528	4585528	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:4585528C>T	ENST00000262352.3	+	12	1781	c.1545C>T	c.(1543-1545)acC>acT	p.T515T		NM_004170.5	NP_004161.4	P43005	EAA3_HUMAN	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	515					D-aspartate import|L-glutamate import|synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|pancreas(1)|skin(1)	15		Acute lymphoblastic leukemia(2;0.0359)|Breast(48;0.0457)		GBM - Glioblastoma multiforme(50;0.0124)|Lung(218;0.183)	L-Aspartic Acid(DB00128)|L-Glutamic Acid(DB00142)	AGTCTGACACCATCTCATTCA	0.473000													20	104					0	0	0.007413	0	0
IGHV4-28	28400	broad.mit.edu	37	14	106780979	106780979	+	RNA	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:106780979G>A	ENST00000390612.2	-	0	38																											CTCTCAGAAAGTATTTCCCAT	0.507000													4	8					0	0	0.003080	0	0
CWH43	80157	broad.mit.edu	37	4	49019268	49019268	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:49019268C>T	ENST00000226432.4	+	9	1372	c.1189C>T	c.(1189-1191)Ctg>Ttg	p.L397L	CWH43_ENST00000513409.1_Silent_p.L370L	NM_025087.2	NP_079363.2	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog (S. cerevisiae)	397					GPI anchor biosynthetic process	integral to membrane				cervix(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(26)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43						CTGTTTAGTTCTGTGGCTGCT	0.368000													32	85					0	0	0.003271	0	0
OR2V2	285659	broad.mit.edu	37	5	180582833	180582833	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:180582833G>A	ENST00000328275.1	+	1	891	c.891G>A	c.(889-891)gaG>gaA	p.E297E		NM_206880.1	NP_996763.1	Q96R30	OR2V2_HUMAN	olfactory receptor, family 2, subfamily V, member 2	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|lung(11)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20	all_cancers(89;8.26e-06)|all_epithelial(37;1.02e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0684)	all_cancers(40;0.0103)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0652)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GGAACAGGGAGGTGATGGGGG	0.607000													13	39					0	0	0.004007	0	0
EIF4G2	1982	broad.mit.edu	37	11	10824772	10824772	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:10824772G>A	ENST00000526148.1	-	10	1393	c.883C>T	c.(883-885)Cgt>Tgt	p.R295C	EIF4G2_ENST00000396525.2_Missense_Mutation_p.R295C|EIF4G2_ENST00000525681.1_Missense_Mutation_p.R295C|EIF4G2_ENST00000339995.5_Missense_Mutation_p.R295C	NM_001172705.1	NP_001166176.1	P78344	IF4G2_HUMAN	eukaryotic translation initiation factor 4 gamma, 2	295	MIF4G.				cell cycle arrest|cell death|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(6)	43				all cancers(16;2.8e-07)|Epithelial(150;4.18e-07)|BRCA - Breast invasive adenocarcinoma(625;0.111)		AGCAGGAAACGAATCCTTGCT	0.333000													13	10					0	0	0.001855	0	0
FZD6	8323	broad.mit.edu	37	8	104340522	104340522	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:104340522G>A	ENST00000358755.4	+	5	1736	c.1419G>A	c.(1417-1419)ttG>ttA	p.L473L	FZD6_ENST00000522566.1_Silent_p.L473L|FZD6_ENST00000540287.1_Silent_p.L168L|FZD6_ENST00000523739.1_Silent_p.L441L	NM_001164616.1|NM_003506.3	NP_001158088.1|NP_003497.2	O60353	FZD6_HUMAN	frizzled family receptor 6	473					angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)|skin(1)|urinary_tract(1)	24			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			GACCAGAATTGGCTTTATTTA	0.343000													24	101					0	0	0.003954	0	0
COL6A1	1291	broad.mit.edu	37	21	47419593	47419593	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:47419593C>T	ENST00000361866.3	+	27	1877	c.1763C>T	c.(1762-1764)cCg>cTg	p.P588L		NM_001848.2	NP_001839.2	P12109	CO6A1_HUMAN	collagen, type VI, alpha 1	588	Triple-helical region.				axon guidance|cell adhesion|protein heterotrimerization	collagen type VI|protein complex	platelet-derived growth factor binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	33	all_hematologic(128;0.24)			Colorectal(79;0.0265)|READ - Rectum adenocarcinoma(84;0.0649)	Palifermin(DB00039)	CACCAAGGACCGCCTGGGCCG	0.637000													6	14					0	0	0.003080	0	0
GDF5	8200	broad.mit.edu	37	20	34021839	34021839	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:34021839G>A	ENST00000374372.1	-	4	1877	c.1374C>T	c.(1372-1374)ccC>ccT	p.P458P	GDF5_ENST00000374369.3_Silent_p.P458P|GDF5OS_ENST00000374375.1_5'UTR			P43026	GDF5_HUMAN	growth differentiation factor 5	458					cartilage development|cell-cell signaling|growth|transforming growth factor beta receptor signaling pathway	extracellular space	cytokine activity|growth factor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(3)|lung(9)|skin(3)	26	Lung NSC(9;0.00642)|all_lung(11;0.0094)		BRCA - Breast invasive adenocarcinoma(18;0.00663)			GTGTGGACTCGGGGTCCATGG	0.582000													10	38					0	0	0.001368	0	0
ATP10D	57205	broad.mit.edu	37	4	47517562	47517562	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:47517562G>A	ENST00000273859.3	+	3	629	c.360G>A	c.(358-360)aaG>aaA	p.K120K	ATP10D_ENST00000504445.1_Silent_p.K120K	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	120					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						CCTTCCAAAAGGAAATCACCA	0.413000													39	147					0	0	0.002222	0	0
UCP2	7351	broad.mit.edu	37	11	73686070	73686070	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:73686070G>A	ENST00000310473.3	-	8	1754	c.912C>T	c.(910-912)tcC>tcT	p.S304S	UCP2_ENST00000536983.1_3'UTR	NM_003355.2	NP_003346.2	P55851	UCP2_HUMAN	uncoupling protein 2 (mitochondrial, proton carrier)	304					proton transport|respiratory electron transport chain	integral to membrane|mitochondrial inner membrane	binding			large_intestine(1)|lung(3)|prostate(1)	5	Breast(11;0.000112)					GAGCCTCTCGGGAAGTGCAGG	0.557000													6	7					0	0	0.001984	0	0
COLEC10	10584	broad.mit.edu	37	8	120101955	120101955	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:120101955G>A	ENST00000332843.2	+	2	226	c.185G>A	c.(184-186)gGa>gAa	p.G62E	COLEC10_ENST00000521788.1_3'UTR	NM_006438.3	NP_006429.2	Q9Y6Z7	COL10_HUMAN	collectin sub-family member 10 (C-type lectin)	62	Collagen-like.					collagen|cytoplasm	mannose binding			endometrium(2)|kidney(3)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	21	all_cancers(13;4.13e-26)|Lung NSC(37;1.36e-07)|Ovarian(258;0.018)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00113)			GGAGAAGAGGGAAAGCATGGC	0.413000													11	34					0	0	0.001855	0	0
GTF3C1	2975	broad.mit.edu	37	16	27476005	27476005	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:27476005G>A	ENST00000356183.4	-	34	5523	c.5508C>T	c.(5506-5508)ccC>ccT	p.P1836P	GTF3C1_ENST00000561623.1_Silent_p.P1836P	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1836						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						ACCCCTCCAGGGGTCTGGCCT	0.672000													15	52					0	0	0.007413	0	0
DAAM2	23500	broad.mit.edu	37	6	39847149	39847149	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:39847149C>T	ENST00000538976.1	+	14	1923	c.1741C>T	c.(1741-1743)Ctc>Ttc	p.L581F	DAAM2_ENST00000274867.4_Missense_Mutation_p.L581F|DAAM2_ENST00000398904.2_Missense_Mutation_p.L581F	NM_015345.3	NP_056160.2	Q86T65	DAAM2_HUMAN	dishevelled associated activator of morphogenesis 2	581	FH1.|Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding	p.L581F(1)		NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(18)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)	49	Ovarian(28;0.0355)|Colorectal(47;0.196)					GGGCCTGCCCCTCCCTCAGGA	0.662000													5	68					0	0	0.000602	0	0
CFAP54	144535	broad.mit.edu	37	12	97073463	97073463	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:97073463C>T	ENST00000524981.3	+	7	1002	c.1002C>T	c.(1000-1002)tcC>tcT	p.S334S				Q6ZTY8	CL063_HUMAN		308										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						TGGAAAAATCCAAATACCATA	0.428000													46	83					0	0	0.002522	0	0
PSMC4	5704	broad.mit.edu	37	19	40480516	40480516	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:40480516C>T	ENST00000157812.2	+	5	753	c.555C>T	c.(553-555)ctC>ctT	p.L185L	PSMC4_ENST00000455878.2_Silent_p.L154L	NM_006503.3|NM_153001.2	NP_006494.1|NP_694546.1	P43686	PRS6B_HUMAN	proteasome (prosome, macropain) 26S subunit, ATPase, 4	185				L -> V (in Ref. 4; AAC32612).	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|urinary_tract(1)	19	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AGCTCCCGCTCACGCATTTCG	0.632000													22	49					0	0	0.005443	0	0
NR4A3	8013	broad.mit.edu	37	9	102590329	102590329	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:102590329C>T	ENST00000330847.1	+	2	82	c.38C>T	c.(37-39)cCc>cTc	p.P13L	NR4A3_ENST00000395097.2_Missense_Mutation_p.P2L|NR4A3_ENST00000338488.4_Missense_Mutation_p.P2L			Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	2					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		TCF12/NR4A3(2)|TAF15/NR4A3(33)|EWSR1/NR4A3(146)|TFG/NR4A3(2)				Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				GCAGATATGCCCTGCGTCCAA	0.512000			T	EWSR1	extraskeletal myxoid chondrosarcoma								16	29					0	0	0.003163	0	0
L1TD1	54596	broad.mit.edu	37	1	62675692	62675692	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:62675692G>A	ENST00000498273.1	+	4	1541	c.1246G>A	c.(1246-1248)Gaa>Aaa	p.E416K		NM_001164835.1|NM_019079.4	NP_001158307.1|NP_061952.3	Q5T7N2	LITD1_HUMAN	LINE-1 type transposase domain containing 1	416	Glu-rich.									breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(2)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	35						gctggaggaggaagaagaaga	0.562000													13	9					0	0	0.001368	0	0
ADAM30	11085	broad.mit.edu	37	1	120436799	120436799	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:120436799C>T	ENST00000369400.1	-	1	2319	c.2161G>A	c.(2161-2163)Gaa>Aaa	p.E721K		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	721					proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		GGCATTTTTTCCTGTTTGGGT	0.353000													204	485					0	0	0.003610	0	0
ANK3	288	broad.mit.edu	37	10	61898772	61898772	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:61898772G>A	ENST00000280772.1	-	24	2879	c.2688C>T	c.(2686-2688)tcC>tcT	p.S896S	ANK3_ENST00000460468.1_Silent_p.S60S|ANK3_ENST00000373827.2_Silent_p.S890S|ANK3_ENST00000355288.2_Silent_p.S30S|ANK3_ENST00000503366.1_Silent_p.S897S	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	896					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTGCAGGCAGGGAATCATCAC	0.468000													25	27					0	0	0.003330	0	0
OR8B8	26493	broad.mit.edu	37	11	124310103	124310103	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:124310103C>T	ENST00000328064.2	-	1	951	c.879G>A	c.(877-879)agG>agA	p.R293R		NM_012378.1	NP_036510.1	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B, member 8	293					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(15)|ovary(1)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		CGTCCTTATTCCTCAGGCTAT	0.408000													19	22					0	0	0.001216	0	0
GPR110	266977	broad.mit.edu	37	6	46996788	46996788	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:46996788C>T	ENST00000371253.2	-	2	225	c.10G>A	c.(10-12)Gga>Aga	p.G4R	GPR110_ENST00000449332.2_5'UTR|GPR110_ENST00000371243.2_Missense_Mutation_p.G4R	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	4					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						CACAGCACTCCAACTTTCATT	0.483000													16	54					0	0	0.004990	0	0
ZNF687	57592	broad.mit.edu	37	1	151262009	151262009	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:151262009A>G	ENST00000368879.2	+	5	2725	c.2627A>G	c.(2626-2628)cAt>cGt	p.H876R		NM_020832.1	NP_065883.1	Q8N1G0	ZN687_HUMAN	zinc finger protein 687	876					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(11)|ovary(1)|upper_aerodigestive_tract(2)	32	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ATGCTGGAACATCTCAAGGTA	0.557000													19	89					0	0	0.001882	0	0
EDEM2	55741	broad.mit.edu	37	20	33725685	33725685	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:33725685G>A	ENST00000540582.1	-	9	1086	c.365C>T	c.(364-366)cCa>cTa	p.P122L	EDEM2_ENST00000374492.3_Missense_Mutation_p.P163L|EDEM2_ENST00000542871.1_Intron|EDEM2_ENST00000541621.1_5'UTR|EDEM2_ENST00000374491.2_Missense_Mutation_p.P126L			Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like 2	163					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|stomach(1)|upper_aerodigestive_tract(2)	22			BRCA - Breast invasive adenocarcinoma(18;0.00936)			GGTCTTACCTGGGAGGAGTTT	0.562000													22	64					0	0	0.001882	0	0
CDS1	1040	broad.mit.edu	37	4	85525461	85525461	+	Silent	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:85525461T>C	ENST00000295887.5	+	2	606	c.183T>C	c.(181-183)atT>atC	p.I61I		NM_001263.3	NP_001254.2	Q92903	CDS1_HUMAN	CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1	61					signal transduction|visual perception	endoplasmic reticulum membrane|integral to membrane	diacylglycerol cholinephosphotransferase activity|phosphatidate cytidylyltransferase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|liver(2)|lung(5)|ovary(1)	20		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.00101)		TTCCGGAAATTCCACCATCCT	0.343000													23	29					0	0	0.002780	0	0
ZDHHC8	29801	broad.mit.edu	37	22	20130629	20130629	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:20130629C>T	ENST00000334554.7	+	10	1617	c.1476C>T	c.(1474-1476)gcC>gcT	p.A492A	ZDHHC8_ENST00000405930.3_Silent_p.A492A|ZDHHC8_ENST00000320602.7_Silent_p.A400A	NM_013373.3	NP_037505.1	Q9ULC8	ZDHC8_HUMAN	zinc finger, DHHC-type containing 8	492						cytoplasmic vesicle membrane|integral to membrane	acyltransferase activity|zinc ion binding			breast(2)|central_nervous_system(3)|endometrium(1)|kidney(3)|large_intestine(1)|lung(8)|ovary(1)|prostate(1)	20	Colorectal(54;0.0993)					GTGGCCACGCCTGCCCTGCCC	0.677000													17	25					0	0	0.007413	0	0
IMP4	92856	broad.mit.edu	37	2	131103620	131103620	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:131103620C>T	ENST00000259239.3	+	7	1332	c.624C>T	c.(622-624)ccC>ccT	p.P208P	IMP4_ENST00000409935.1_Silent_p.P208P	NM_033416.1	NP_219484.1	Q96G21	IMP4_HUMAN	IMP4, U3 small nucleolar ribonucleoprotein, homolog (yeast)	208	Brix.				rRNA processing|translation	nucleolus|ribonucleoprotein complex	aminoacyl-tRNA ligase activity|ATP binding|protein binding	p.P208P(1)		central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|urinary_tract(1)	18	Colorectal(110;0.1)					ACCTATTTCCCGTGCCCAAAG	0.592000													20	31					0	0	0.001882	0	0
MORC1	27136	broad.mit.edu	37	3	108725901	108725901	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:108725901G>A	ENST00000232603.5	-	18	1824	c.1742C>T	c.(1741-1743)tCc>tTc	p.S581F	MORC1_ENST00000483760.1_Intron	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	581					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						TAGGCAGGTGGAAGTGACAGT	0.388000													19	41					0	0	0.001882	0	0
ADCY10	55811	broad.mit.edu	37	1	167805628	167805628	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:167805628C>T	ENST00000367848.1	-	23	3449	c.2952G>A	c.(2950-2952)ctG>ctA	p.L984L	ADCY10_ENST00000485964.1_Intron|ADCY10_ENST00000545172.1_Silent_p.L923L|ADCY10_ENST00000367851.4_Silent_p.L1076L			Q96PN6	ADCYA_HUMAN	adenylate cyclase 10 (soluble)	1076					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(3)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|lung(26)|ovary(2)|prostate(4)|skin(6)|stomach(1)|urinary_tract(1)	63						CTCCCAAAGCCAGAAAATGGT	0.398000													24	60					0	0	0.002780	0	0
GABRR1	2569	broad.mit.edu	37	6	89910935	89910935	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:89910935A>T	ENST00000435811.1	-	2	626	c.172T>A	c.(172-174)Tca>Aca	p.S58T	GABRR1_ENST00000369451.3_5'UTR|GABRR1_ENST00000454853.2_Missense_Mutation_p.S75T	NM_001256703.1	NP_001243632.1	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 1	75					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity	p.S69T(1)		cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(7)|lung(16)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	35		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	AGCTGTTCTGACTTTGTCAGA	0.488000													28	49					0	0	0.001786	0	0
AOC4P	90586	broad.mit.edu	37	17	41020460	41020460	+	RNA	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:41020460G>A	ENST00000585538.1	+	0	1299					NR_002773.1																						TAGTGGCTTTGGCTTGGGCCA	0.592000													5	3					0	0	0.000602	0	0
KIAA1549	57670	broad.mit.edu	37	7	138602377	138602377	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:138602377G>A	ENST00000440172.1	-	2	2043	c.1995C>T	c.(1993-1995)ccC>ccT	p.P665P	KIAA1549_ENST00000422774.1_Silent_p.P665P|KIAA1549_ENST00000242365.4_Silent_p.P615P	NM_001164665.1|NM_020910.2	NP_001158137.1|NP_065961.2	Q9HCM3	K1549_HUMAN	KIAA1549	665	Ser-rich.					integral to membrane			KIAA1549/BRAF(703)	large_intestine(4)|pancreas(1)|upper_aerodigestive_tract(2)	7						TCTCAACCAAGGGAGAAAAAG	0.498000			O	BRAF	pilocytic astrocytoma								8	12					0	0	0.003080	0	0
TTBK1	84630	broad.mit.edu	37	6	43226883	43226883	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43226883C>T	ENST00000259750.4	+	11	1207	c.1124C>T	c.(1123-1125)cCc>cTc	p.P375L	TTBK1_ENST00000304139.5_Missense_Mutation_p.P324L	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	375						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CCAATTCTGCCCGGGAGGCCC	0.647000													18	103					0	0	0.001523	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41721580	41721580	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:41721580C>T	ENST00000352645.4	+	3	323	c.66C>T	c.(64-66)ccC>ccT	p.P22P	ZC3H7B_ENST00000351589.4_Silent_p.P22P	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	22					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						CGACACTACCCCTAAAGCAAG	0.587000													4	36					0	0	0.000248	0	0
CARD11	84433	broad.mit.edu	37	7	2987262	2987262	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2987262T>A	ENST00000396946.4	-	3	570	c.167A>T	c.(166-168)gAt>gTt	p.D56V		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	56	CARD.				positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		TTCATCTTCATCCTGCTCATC	0.547000			Mis		DLBCL								28	208					0	0	0.002096	0	0
TCTEX1D1	200132	broad.mit.edu	37	1	67236143	67236143	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:67236143G>A	ENST00000282670.2	+	3	321	c.193G>A	c.(193-195)Gaa>Aaa	p.E65K	TCTEX1D1_ENST00000491611.1_3'UTR	NM_152665.2	NP_689878.2	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	65										large_intestine(2)|lung(10)|skin(1)	13						AGTTCAGATGGAAAACACCTA	0.353000													53	73					0	0	0.003610	0	0
DNAH7	56171	broad.mit.edu	37	2	196619129	196619129	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:196619129G>A	ENST00000312428.6	-	63	11796	c.11696C>T	c.(11695-11697)cCt>cTt	p.P3899L	DNAH7_ENST00000409063.1_Missense_Mutation_p.P382L	NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3899					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						AAGATCAATAGGAATTGTGTA	0.483000													15	20					0	0	0.003163	0	0
NXN	64359	broad.mit.edu	37	17	722783	722783	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:722783G>A	ENST00000336868.3	-	5	807	c.716C>T	c.(715-717)tCg>tTg	p.S239L	NXN_ENST00000575801.1_Missense_Mutation_p.S131L|NXN_ENST00000537628.2_5'UTR|NXN_ENST00000538650.1_5'UTR	NM_022463.4	NP_071908.2	Q6DKJ4	NXN_HUMAN	nucleoredoxin	239	Thioredoxin.				cell differentiation|cell redox homeostasis|multicellular organismal development|Wnt receptor signaling pathway	cytosol|nucleus	protein-disulfide reductase activity			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(2)|ovary(2)|pancreas(1)|prostate(1)	13				UCEC - Uterine corpus endometrioid carcinoma (25;0.0237)		GGACTCCTCCGACCTACAGAG	0.617000													18	16					0	0	0.007413	0	0
RP11-50E11.3	0	broad.mit.edu	37	10	52390795	52390795	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:52390795C>T	ENST00000443374.1	+	0	1488																											GGTAAAAATTCCTTTATCTGC	0.488000													4	12					0	0	0.000248	0	0
SIGLEC6	946	broad.mit.edu	37	19	52031489	52031489	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:52031489G>A	ENST00000346477.3	-	5	1051	c.983C>T	c.(982-984)gCt>gTt	p.A328V	SIGLEC6_ENST00000436458.1_Missense_Mutation_p.A292V|SIGLEC6_ENST00000474054.1_5'UTR|SIGLEC6_ENST00000425629.3_Missense_Mutation_p.A344V|SIGLEC6_ENST00000359982.4_Missense_Mutation_p.A355V|SIGLEC6_ENST00000343300.4_Intron|SIGLEC6_ENST00000391797.3_Intron	NM_198845.4	NP_942142.3	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6	344	Ig-like C2-type 2.				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				endometrium(3)|kidney(1)|large_intestine(6)|liver(1)|lung(15)|ovary(1)|stomach(1)	28		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GACACCACCAGCCCTGCCTTC	0.507000													10	25					0	0	0.001368	0	0
MAP4K4	9448	broad.mit.edu	37	2	102477313	102477313	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:102477313C>T	ENST00000425019.1	+	16	1975	c.1638C>T	c.(1636-1638)aaC>aaT	p.N546N	MAP4K4_ENST00000350198.4_Intron|MAP4K4_ENST00000324219.4_Silent_p.N577N|MAP4K4_ENST00000302217.5_Intron|MAP4K4_ENST00000347699.4_Silent_p.N577N|MAP4K4_ENST00000350878.4_Intron|MAP4K4_ENST00000413150.2_Intron|MAP4K4_ENST00000456652.1_Intron	NM_145686.3	NP_663719.2	O95819	M4K4_HUMAN	mitogen-activated protein kinase kinase kinase kinase 4	577					intracellular protein kinase cascade|regulation of JNK cascade|response to stress	cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity	p.N577K(1)		breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(15)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						GGAAAACTAACCACAGCTCCC	0.448000													7	3					0	0	0.000673	0	0
CADPS2	93664	broad.mit.edu	37	7	122019443	122019443	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:122019443G>A	ENST00000334010.7	-	23	3781	c.3360C>T	c.(3358-3360)atC>atT	p.I1120I	CADPS2_ENST00000449022.2_Silent_p.I1122I|CADPS2_ENST00000313070.7_Silent_p.I1081I|RP5-1101C3.1_ENST00000591140.1_RNA|RP5-1101C3.1_ENST00000593910.1_RNA|CADPS2_ENST00000412584.2_Silent_p.I1081I	NM_001167940.1	NP_001161412.1	Q86UW7	CAPS2_HUMAN	Ca++-dependent secretion activator 2	1122					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(26)|ovary(2)	43						ACAGTGAAATGATTTCTTTTA	0.259000													7	19					0	0	0.004482	0	0
IGHV6-1	28385	broad.mit.edu	37	14	106406010	106406010	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:106406010C>T	ENST00000390593.2	-	0	98																											ACACTGACCCCATGGGAGGCC	0.557000													13	11					0	0	0.001855	0	0
LRRN4CL	221091	broad.mit.edu	37	11	62455825	62455825	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:62455825G>A	ENST00000317449.4	-	2	633	c.156C>T	c.(154-156)caC>caT	p.H52H		NM_203422.2	NP_981967.1	Q8ND94	LRN4L_HUMAN	LRRN4 C-terminal like	52						integral to membrane				cervix(1)|kidney(1)	2						GGTGTCGGCAGTGGTCGTAGT	0.687000													8	18					0	0	0.004482	0	0
KCNA4	3739	broad.mit.edu	37	11	30032383	30032383	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:30032383C>T	ENST00000328224.6	-	2	3076	c.1843G>A	c.(1843-1845)Gaa>Aaa	p.E615K		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	615						voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						ACTCCTTCTTCCATCTCTAGA	0.453000													22	28					0	0	0.001523	0	0
GPR115	221393	broad.mit.edu	37	6	47680130	47680130	+	Missense_Mutation	SNP	C	C	T	rs149916768	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:47680130C>T	ENST00000283303.2	+	5	596	c.338C>T	c.(337-339)cCa>cTa	p.P113L	GPR115_ENST00000327753.3_Missense_Mutation_p.P113L|GPR115_ENST00000371220.1_Missense_Mutation_p.P170L	NM_153838.3	NP_722580.3	Q8IZF3	GP115_HUMAN	G protein-coupled receptor 115	113					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(24)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	52						GTAGCAGCACCATCTATACCT	0.413000													26	207					0	0	0.006320	0	0
ATP9A	10079	broad.mit.edu	37	20	50226668	50226668	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:50226668G>A	ENST00000338821.5	-	24	2872	c.2608C>T	c.(2608-2610)Cct>Tct	p.P870S	ATP9A_ENST00000402822.1_Missense_Mutation_p.P749S|ATP9A_ENST00000311637.5_Missense_Mutation_p.P734S	NM_006045.1	NP_006036.1	O75110	ATP9A_HUMAN	ATPase, class II, type 9A	870					ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(2)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(10)|lung(18)|ovary(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						TGATAGAGAGGGACGGAGGCA	0.423000													21	74					0	0	0.003954	0	0
SRPK1	6732	broad.mit.edu	37	6	35825091	35825091	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:35825091G>A	ENST00000373825.2	-	13	1852	c.1567C>T	c.(1567-1569)Cta>Tta	p.L523L	SRPK1_ENST00000423325.2_Silent_p.L507L|SRPK1_ENST00000373822.1_Silent_p.L415L			Q96SB4	SRPK1_HUMAN	SRSF protein kinase 1	523	Protein kinase.				cell differentiation|chromosome segregation|interspecies interaction between organisms|intracellular protein kinase cascade|mRNA processing|negative regulation of viral genome replication|positive regulation of viral genome replication|regulation of mRNA processing|RNA splicing	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			endometrium(2)|large_intestine(10)|lung(6)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21						GATCCGATTAGAACTTCCAAG	0.368000													10	43					0	0	0.001368	0	0
ZNF831	128611	broad.mit.edu	37	20	57769544	57769544	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:57769544G>A	ENST00000371030.2	+	1	3470	c.3470G>A	c.(3469-3471)gGg>gAg	p.G1157E		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1157						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					TCCCACTCAGGGACGTCCCGG	0.677000													15	50					0	0	0.001216	0	0
PDGFRA	5156	broad.mit.edu	37	4	55138611	55138611	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:55138611G>A	ENST00000257290.5	+	9	1619	c.1288G>A	c.(1288-1290)Gga>Aga	p.G430R	FIP1L1_ENST00000507166.1_Intron	NM_006206.4	NP_006197.1	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor, alpha polypeptide	430	Ig-like C2-type 5.				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			NS(1)|autonomic_ganglia(1)|bone(1)|breast(4)|central_nervous_system(17)|cervix(1)|endometrium(4)|eye(1)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(22)|kidney(6)|large_intestine(26)|liver(4)|lung(48)|ovary(4)|prostate(6)|skin(11)|small_intestine(49)|soft_tissue(727)|stomach(32)|urinary_tract(1)	967	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CTCAACTGGGGGACAGACGGT	0.473000			"""Mis, O, T"""	FIP1L1	"""GIST, idiopathic hypereosinophilic syndrome, paediatric GBM"""				Gastrointestinal Stromal Tumors, Sporadic Multiple Primary;Familial Intestinal Neurofibromatosis	TSP Lung(21;0.16)			24	150					0	0	0.002780	0	0
ITGA8	8516	broad.mit.edu	37	10	15614220	15614220	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:15614220T>C	ENST00000378076.3	-	25	2980	c.2627A>G	c.(2626-2628)cAg>cGg	p.Q876R		NM_003638.1	NP_003629.1	P53708	ITA8_HUMAN	integrin, alpha 8	876					cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			NS(2)|breast(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(57)|ovary(3)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	96						CTTTATATCCTGTGGATTGAT	0.383000													24	38					0	0	0.006320	0	0
KCNK2	3776	broad.mit.edu	37	1	215259779	215259779	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:215259779A>C	ENST00000444842.2	+	2	265	c.115A>C	c.(115-117)Acg>Ccg	p.T39P	KCNK2_ENST00000391894.2_Missense_Mutation_p.T24P|KCNK2_ENST00000391895.2_Missense_Mutation_p.T35P	NM_001017425.2|NM_014217.3	NP_001017425.2|NP_055032.1	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2	39							outward rectifier potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(15)|upper_aerodigestive_tract(1)	30				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	CTCGTTTTCCACGAAACCCAC	0.512000													53	15					0	0	0.003610	0	0
UGT2B28	54490	broad.mit.edu	37	4	70156380	70156380	+	Silent	SNP	G	G	A	rs143921369		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:70156380G>A	ENST00000335568.5	+	5	1163	c.1161G>A	c.(1159-1161)ggG>ggA	p.G387G	UGT2B28_ENST00000511240.1_Intron	NM_053039.1	NP_444267.1	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family, polypeptide B28	387					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity	p.G387G(1)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(16)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31					Flunitrazepam(DB01544)	TCTACCATGGGATCCCTATGG	0.428000													61	93					0	0	0.003610	0	0
ZNF17	7565	broad.mit.edu	37	19	57932571	57932571	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57932571C>T	ENST00000307658.7	+	4	1980	c.1717C>T	c.(1717-1719)Cgg>Tgg	p.R573W	AC004076.7_ENST00000597410.1_Intron|ZNF17_ENST00000601808.1_Missense_Mutation_p.R571W			P17021	ZNF17_HUMAN	zinc finger protein 17	571					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.R571W(1)		central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0234)|GBM - Glioblastoma multiforme(193;0.000426)|Lung(386;0.176)		CCACCTCATTCGGCACCAAAA	0.403000													16	28					0	0	0.006122	0	0
KIAA0247	9766	broad.mit.edu	37	14	70170167	70170167	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:70170167C>T	ENST00000342745.4	+	3	490	c.177C>T	c.(175-177)ccC>ccT	p.P59P		NM_014734.3	NP_055549.1	Q92537	K0247_HUMAN	KIAA0247	59	Sushi.					integral to membrane				endometrium(1)|kidney(1)|lung(4)|ovary(3)|upper_aerodigestive_tract(1)	10				all cancers(60;0.00155)|BRCA - Breast invasive adenocarcinoma(234;0.0164)|OV - Ovarian serous cystadenocarcinoma(108;0.0196)		ACCCCCGGCCCTGCAGAGACC	0.567000													22	29					0	0	0.001882	0	0
CD200R1L	344807	broad.mit.edu	37	3	112545993	112545993	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:112545993C>A	ENST00000488794.1	-	6	1052	c.463G>T	c.(463-465)Gag>Tag	p.E155*	CD200R1L_ENST00000398214.1_Nonsense_Mutation_p.E176*|CD200R1L_ENST00000448932.1_Nonsense_Mutation_p.E155*			Q6Q8B3	MO2R2_HUMAN	CD200 receptor 1-like	176	Ig-like C2-type.					integral to membrane	receptor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(6)|ovary(1)|prostate(2)|urinary_tract(2)	19						ATAGATCCCTCTGGGATCCAG	0.507000													10	25					7.48243e-07	1.2724e-06	0.006214	1	0
CSMD3	114788	broad.mit.edu	37	8	113960098	113960098	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:113960098C>T	ENST00000297405.5	-	9	1673	c.1429G>A	c.(1429-1431)Gga>Aga	p.G477R	CSMD3_ENST00000352409.3_Missense_Mutation_p.G477R|CSMD3_ENST00000343508.3_Missense_Mutation_p.G437R|CSMD3_ENST00000455883.2_Missense_Mutation_p.G373R	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	477						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						TTAATACCTCCCTCATTTACT	0.289000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			8	86					0	0	0.004482	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110441657	110441657	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:110441657G>A	ENST00000378402.5	+	26	3193	c.3089G>A	c.(3088-3090)gGa>gAa	p.G1030E		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1030					immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			CATGTACTTGGAGACCTACTT	0.328000										HNSCC(38;0.096)			4	37					0	0	0.000602	0	0
ERBB4	2066	broad.mit.edu	37	2	212483927	212483927	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:212483927G>A	ENST00000342788.4	-	19	2586	c.2276C>T	c.(2275-2277)cCc>cTc	p.P759L	ERBB4_ENST00000436443.1_Missense_Mutation_p.P759L|ERBB4_ENST00000402597.1_Missense_Mutation_p.P749L	NM_005235.2	NP_005226.1	Q15303	ERBB4_HUMAN	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4	759	Protein kinase.				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(7)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(31)|lung(71)|pancreas(1)|prostate(3)|skin(39)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	179		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		ATTTGCCTTGGGACCAGTTGT	0.368000										TSP Lung(8;0.080)			18	21					0	0	0.001882	0	0
ZNF221	7638	broad.mit.edu	37	19	44471126	44471126	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:44471126C>T	ENST00000251269.5	+	6	1800	c.1472C>T	c.(1471-1473)tCc>tTc	p.S491F	ZNF221_ENST00000587682.1_Missense_Mutation_p.S491F|ZNF221_ENST00000592350.1_Missense_Mutation_p.S491F	NM_013359.2	NP_037491.2	Q9UK13	ZN221_HUMAN	zinc finger protein 221	491					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(11)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	30		Prostate(69;0.0352)				GGCTGGGCCTCCTGTCTTTTG	0.448000													21	27					0	0	0.001882	0	0
LRG1	116844	broad.mit.edu	37	19	4538435	4538435	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:4538435G>A	ENST00000306390.6	-	2	1021	c.561C>T	c.(559-561)ttC>ttT	p.F187F	CTB-50L17.14_ENST00000586020.1_Intron	NM_052972.2	NP_443204.1	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1	187						extracellular region|membrane				NS(1)|endometrium(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	13		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGGAGGGTGAAGTTGGCCA	0.617000													52	81					0	0	0.003610	0	0
SPIRE2	84501	broad.mit.edu	37	16	89922062	89922062	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:89922062G>A	ENST00000378247.3	+	6	989	c.946G>A	c.(946-948)Gac>Aac	p.D316N	SPIRE2_ENST00000393062.2_Missense_Mutation_p.D316N	NM_032451.1	NP_115827.1	Q8WWL2	SPIR2_HUMAN	spire-type actin nucleation factor 2	316					transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		GCTCATCCTGGACTTTATCCG	0.677000													11	23					0	0	0.002450	0	0
CAPN11	11131	broad.mit.edu	37	6	44149035	44149035	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:44149035G>A	ENST00000542245.1	+	19	1954	c.1916G>A	c.(1915-1917)tGg>tAg	p.W639*	CAPN11_ENST00000398776.1_Nonsense_Mutation_p.W639*			Q9UMQ6	CAN11_HUMAN	calpain 11	639	Domain IV.|EF-hand 1.				proteolysis	acrosomal vesicle	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)	36	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			AAGATCCTGTGGAAAAAACTC	0.512000													17	70					0	0	0.001882	0	0
SLC25A53	401612	broad.mit.edu	37	X	103349732	103349732	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:103349732C>T	ENST00000357421.4	-	2	389	c.209G>A	c.(208-210)tGg>tAg	p.W70*		NM_001012755.3	NP_001012773.2	Q5H9E4	MCAR6_HUMAN	solute carrier family 25, member 53	70					transport	integral to membrane|mitochondrial inner membrane											ACCTTCATGCCAAAGCTGTCT	0.478000													21	6					0	0	0.001882	0	0
IL20	50604	broad.mit.edu	37	1	207039919	207039919	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:207039919C>T	ENST00000367098.1	+	4	679	c.316C>T	c.(316-318)Ctc>Ttc	p.L106F	IL20_ENST00000391930.2_Missense_Mutation_p.L106F|IL20_ENST00000367096.3_Missense_Mutation_p.L106F			Q9NYY1	IL20_HUMAN	interleukin 20	106					positive regulation of keratinocyte differentiation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of inflammatory response	extracellular space	cytokine activity|interleukin-20 receptor binding			endometrium(2)|large_intestine(3)|lung(2)|pancreas(1)|urinary_tract(1)	9	Breast(84;0.201)			OV - Ovarian serous cystadenocarcinoma(81;0.00459)		CCATTATACTCTCCGGAAGAT	0.502000													246	92					0	0	0.003610	0	0
CLPSL2	389383	broad.mit.edu	37	6	35747255	35747255	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:35747255C>T	ENST00000360454.2	+	4	414	c.410C>T	c.(409-411)cCt>cTt	p.P137L	CLPSL2_ENST00000403376.3_3'UTR|CLPSL2_ENST00000481904.1_3'UTR			Q6UWE3	CF126_HUMAN	colipase-like 2	0					digestion|lipid catabolic process	extracellular region	enzyme activator activity										TCACTGCTCCCTTGGGGCCAT	0.547000													3	6					0	0	0.004672	0	0
SEMA3G	56920	broad.mit.edu	37	3	52475386	52475386	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:52475386G>A	ENST00000231721.2	-	7	706	c.707C>T	c.(706-708)tCt>tTt	p.S236F		NM_020163.1	NP_064548.1	Q9NS98	SEM3G_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G	236	Sema.				multicellular organismal development	extracellular region|membrane	receptor activity			kidney(1)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)	18				BRCA - Breast invasive adenocarcinoma(193;1.69e-05)|Kidney(197;0.00173)|KIRC - Kidney renal clear cell carcinoma(197;0.00196)|OV - Ovarian serous cystadenocarcinoma(275;0.0333)		GTCCTGGTCAGAGTTCTCAGG	0.627000													24	36					0	0	0.003954	0	0
CYP2B7P	1556	broad.mit.edu	37	19	41442004	41442004	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:41442004C>T	ENST00000599198.1	+	0	228					NR_001278.1															NS(1)|endometrium(6)|kidney(1)|lung(2)|ovary(1)|skin(1)	12						ATTGGCAGTTCCGAGAGAAAT	0.517000													6	13					0	0	0.003080	0	0
CYP17A1	1586	broad.mit.edu	37	10	104596920	104596920	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:104596920G>A	ENST00000369887.3	-	1	370	c.199C>T	c.(199-201)Cgt>Tgt	p.R67C	CYP17A1_ENST00000489268.1_5'UTR	NM_000102.3	NP_000093.1	P05093	CP17A_HUMAN	cytochrome P450, family 17, subfamily A, polypeptide 1	67					androgen biosynthetic process|glucocorticoid biosynthetic process|sex differentiation|xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|oxygen binding|steroid 17-alpha-monooxygenase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(2)	18		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;3.93e-09)|all cancers(201;1.02e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)	NADH(DB00157)|Progesterone(DB00396)	GTGCCCATACGAACCGAATAG	0.542000													27	51					0	0	0.002096	0	0
TRAPPC5	126003	broad.mit.edu	37	19	7747303	7747303	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:7747303C>T	ENST00000317378.5	+	2	351	c.164C>T	c.(163-165)gCc>gTc	p.A55V	TRAPPC5_ENST00000595985.1_Intron|TRAPPC5_ENST00000596148.1_Missense_Mutation_p.A55V|TRAPPC5_ENST00000426877.2_Missense_Mutation_p.A55V|CTD-3214H19.16_ENST00000597959.1_Missense_Mutation_p.P114S	NM_174894.2	NP_777554.1	Q8IUR0	TPPC5_HUMAN	trafficking protein particle complex 5	55					vesicle-mediated transport	endoplasmic reticulum	guanylate cyclase activity|heme binding			NS(1)|lung(2)	3						TCGCGCCTGGCCGCGCTGGGC	0.701000													3	0					0	0	0.004672	0	0
PRKCB	5579	broad.mit.edu	37	16	24104231	24104231	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:24104231T>C	ENST00000303531.7	+	6	801	c.649T>C	c.(649-651)Tgc>Cgc	p.C217R	PRKCB_ENST00000321728.7_Missense_Mutation_p.C217R|PRKCB_ENST00000482000.1_3'UTR	NM_002738.6	NP_002729.2	P05771	KPCB_HUMAN	protein kinase C, beta	217	C2.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			central_nervous_system(3)|large_intestine(1)|lung(2)|ovary(3)	9					Vitamin E(DB00163)	AACCATCAAATGCTCCCTCAA	0.468000													23	30					0	0	0.003330	0	0
FLG2	388698	broad.mit.edu	37	1	152324716	152324716	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:152324716C>T	ENST00000388718.5	-	3	5618	c.5546G>A	c.(5545-5547)gGa>gAa	p.G1849E	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1849							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTGTCTGTCCATGAGTAGT	0.502000													56	175					0	0	0.003610	0	0
PAK4	10298	broad.mit.edu	37	19	39667319	39667319	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:39667319C>T	ENST00000599386.1	+	7	1171	c.990C>T	c.(988-990)gcC>gcT	p.A330A	PAK4_ENST00000360442.3_Silent_p.A483A|PAK4_ENST00000358301.3_Silent_p.A483A|PAK4_ENST00000599470.1_Silent_p.A330A|PAK4_ENST00000593690.1_Silent_p.A483A|PAK4_ENST00000435673.2_Silent_p.A483A|PAK4_ENST00000321944.4_Silent_p.A393A	NM_001014835.1	NP_001014835.1	O96013	PAK4_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 4	483	Protein kinase.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)	13	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			ACTGGATGGCCCCAGAGCTCA	0.647000													34	96					0	0	0.004289	0	0
IGSF3	3321	broad.mit.edu	37	1	117122046	117122046	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:117122046G>A	ENST00000369486.3	-	10	4067	c.3302C>T	c.(3301-3303)tCa>tTa	p.S1101L	IGSF3_ENST00000318837.6_Missense_Mutation_p.S1121L|IGSF3_ENST00000369483.1_Missense_Mutation_p.S1121L	NM_001007237.1	NP_001007238.1	O75054	IGSF3_HUMAN	immunoglobulin superfamily, member 3	1101						integral to membrane				NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(31)|ovary(4)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	62	Lung SC(450;0.225)	all_cancers(81;1.24e-06)|all_epithelial(167;4.85e-07)|all_lung(203;1.66e-06)|Lung NSC(69;1.11e-05)		Lung(183;0.0142)|Colorectal(144;0.0929)|LUSC - Lung squamous cell carcinoma(189;0.108)|COAD - Colon adenocarcinoma(174;0.139)|all cancers(265;0.159)|Epithelial(280;0.166)		GATGGGGGCTGACTCCTCCTC	0.537000													29	59					0	0	0.002096	0	0
OR6C76	390326	broad.mit.edu	37	12	55820729	55820729	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:55820729G>A	ENST00000328314.3	+	1	692	c.692G>A	c.(691-693)aGa>aAa	p.R231K		NM_001005183.1	NP_001005183.1	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C, member 76	231					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	14						GCACAGCAAAGAAAAAAAGCC	0.368000													17	27					0	0	0.006122	0	0
GSE1	23199	broad.mit.edu	37	16	85694852	85694852	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:85694852C>G	ENST00000253458.7	+	9	1917	c.1741C>G	c.(1741-1743)Ccc>Gcc	p.P581A	GSE1_ENST00000405402.2_Missense_Mutation_p.P477A|GSE1_ENST00000393243.1_Missense_Mutation_p.P508A	NM_014615.2	NP_055430.1			Gse1 coiled-coil protein																		CCATGCTGCACCCACGGCCCT	0.662000													25	46					0	0	0.003954	0	0
PTPRT	11122	broad.mit.edu	37	20	41306605	41306605	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:41306605G>A	ENST00000373198.3	-	7	1289	c.1054C>T	c.(1054-1056)Ccc>Tcc	p.P352S	PTPRT_ENST00000356100.2_Missense_Mutation_p.P352S|PTPRT_ENST00000373201.1_Missense_Mutation_p.P352S|PTPRT_ENST00000373193.3_Missense_Mutation_p.P352S|PTPRT_ENST00000373187.1_Missense_Mutation_p.P352S|PTPRT_ENST00000373184.1_Missense_Mutation_p.P352S|PTPRT_ENST00000373190.1_Missense_Mutation_p.P352S	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	352	Fibronectin type-III 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity	p.P352A(1)		NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				TCAACATCGGGGTCCAGATGC	0.597000													29	69					0	0	0.007291	0	0
CAMTA1	23261	broad.mit.edu	37	1	7724259	7724259	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:7724259C>T	ENST00000303635.7	+	9	1859	c.1652C>T	c.(1651-1653)tCc>tTc	p.S551F	CAMTA1_ENST00000439411.2_Missense_Mutation_p.S551F	NM_015215.2	NP_056030.1	Q9Y6Y1	CMTA1_HUMAN	calmodulin binding transcription activator 1	551					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calmodulin binding			breast(5)|central_nervous_system(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(11)|lung(29)|ovary(5)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	85	Ovarian(185;0.0634)	all_epithelial(116;8.38e-23)|all_lung(118;5.87e-07)|Lung NSC(185;3.43e-06)|Renal(390;0.000219)|Breast(487;0.000307)|Colorectal(325;0.000615)|Hepatocellular(190;0.0088)|Myeloproliferative disorder(586;0.0303)|Ovarian(437;0.0388)		UCEC - Uterine corpus endometrioid carcinoma (279;0.101)|Colorectal(212;1.33e-05)|COAD - Colon adenocarcinoma(227;0.000235)|BRCA - Breast invasive adenocarcinoma(304;0.000864)|Kidney(185;0.00244)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0179)|READ - Rectum adenocarcinoma(331;0.133)		TACTCCTCCTCCGCGGCGGCT	0.667000			T	WWTR1	epitheliod hemangioendothelioma								11	38					0	0	0.001368	0	0
TNNI2	7136	broad.mit.edu	37	11	1862718	1862718	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:1862718G>A	ENST00000381906.1	+	8	555	c.486G>A	c.(484-486)agG>agA	p.R162R	TNNI2_ENST00000252898.7_Silent_p.R162R|TNNI2_ENST00000381905.3_Silent_p.R162R|TNNI2_ENST00000381911.1_Silent_p.R162R	NM_001145829.1	NP_001139301.1	P48788	TNNI2_HUMAN	troponin I type 2 (skeletal, fast)	162					muscle filament sliding|positive regulation of transcription, DNA-dependent|skeletal muscle contraction	cytosol|nucleus|troponin complex	actin binding|troponin T binding			lung(8)|prostate(1)|urinary_tract(1)	10		all_epithelial(84;0.000138)|Breast(177;0.000962)|Ovarian(85;0.0014)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		GTGACTGGAGGAAGAACATCG	0.642000													15	25					0	0	0.006122	0	0
DHRS7C	201140	broad.mit.edu	37	17	9694460	9694460	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:9694460C>T	ENST00000330255.4	-	1	154	c.142G>A	c.(142-144)Gga>Aga	p.G48R	DHRS7C_ENST00000571134.1_Missense_Mutation_p.G48R	NM_001220493.1	NP_001207422.1	A6NNS2	DRS7C_HUMAN	dehydrogenase/reductase (SDR family) member 7C	48						extracellular region	binding|oxidoreductase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(9)	15						TTGCCCAGTCCTGAGATGGCA	0.602000													3	4					0	0	0.000248	0	0
SDR42E1	93517	broad.mit.edu	37	16	82033037	82033037	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:82033037G>A	ENST00000328945.5	-	3	988	c.861C>T	c.(859-861)gtC>gtT	p.V287V		NM_145168.2	NP_660151.2	Q8WUS8	D42E1_HUMAN	short chain dehydrogenase/reductase family 42E, member 1	287					steroid biosynthetic process	integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding			NS(2)|endometrium(1)|lung(4)|skin(3)	10						CAAAGCAGTAGACCAAGGTCA	0.507000													18	38					0	0	0.007413	0	0
MUC4	4585	broad.mit.edu	37	3	195517616	195517616	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:195517616C>T	ENST00000463781.3	-	2	1294	c.835G>A	c.(835-837)Gag>Aag	p.E279K	MUC4_ENST00000475231.1_Missense_Mutation_p.E279K|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	284					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GATGATGTCTCCCCTGGGTTT	0.468000													19	54					0	0	0.007413	0	0
P2RY1	5028	broad.mit.edu	37	3	152554131	152554131	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:152554131T>A	ENST00000305097.3	+	1	1396	c.560T>A	c.(559-561)cTc>cAc	p.L187H		NM_002563.3	NP_002554.1	P47900	P2RY1_HUMAN	purinergic receptor P2Y, G-protein coupled, 1	187					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation	integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			breast(1)|endometrium(1)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)	23			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			TCCCCCATCCTCTTCTACTCA	0.532000													23	59					0	0	0.003330	0	0
SYNE1	23345	broad.mit.edu	37	6	152725395	152725395	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:152725395C>A	ENST00000367255.5	-	46	7379	c.6778G>T	c.(6778-6780)Gat>Tat	p.D2260Y	SYNE1_ENST00000448038.1_Missense_Mutation_p.D2267Y|SYNE1_ENST00000265368.4_Missense_Mutation_p.D2260Y|RP3-398G3.5_ENST00000458194.1_RNA|SYNE1_ENST00000341594.5_Missense_Mutation_p.D2297Y|SYNE1_ENST00000423061.1_Missense_Mutation_p.D2267Y	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2260					cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCTTTCAGATCATTAACTTTG	0.338000										HNSCC(10;0.0054)			23	46					1.5548e-18	2.65775e-18	0.005443	1	0
GABBR1	2550	broad.mit.edu	37	6	29572283	29572283	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:29572283C>T	ENST00000377034.4	-	22	3035	c.2700G>A	c.(2698-2700)aaG>aaA	p.K900K	GABBR1_ENST00000377016.4_Silent_p.K838K|GABBR1_ENST00000355973.3_Silent_p.K783K|GABBR1_ENST00000377012.4_Silent_p.K783K|GABBR1_ENST00000376977.3_3'UTR	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	900	Interaction with ATF4 (By similarity).				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	CAGCAATGATCTTTTCCAGTT	0.562000													52	196					0	0	0.003610	0	0
DCSTAMP	81501	broad.mit.edu	37	8	105367188	105367188	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:105367188C>T	ENST00000297581.2	+	3	1162	c.1113C>T	c.(1111-1113)ttC>ttT	p.F371F	DPYS_ENST00000521601.1_Intron|DCSTAMP_ENST00000517991.1_Intron	NM_030788.3	NP_110415.1	Q9H295	TM7S4_HUMAN	dendrocyte expressed seven transmembrane protein	371					osteoclast differentiation	cell surface|integral to membrane|plasma membrane											AACCAAAATTCCTTCTATCTG	0.353000													35	79					0	0	0.003271	0	0
FLRT3	23767	broad.mit.edu	37	20	14306424	14306424	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:14306424C>T	ENST00000378053.3	-	2	1985	c.1729G>A	c.(1729-1731)Gaa>Aaa	p.E577K	MACROD2_ENST00000310348.4_Intron|MACROD2_ENST00000217246.4_Intron|FLRT3_ENST00000341420.4_Missense_Mutation_p.E577K	NM_013281.3	NP_037413.1	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	577					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			breast(1)|kidney(2)|large_intestine(5)|lung(5)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	17		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		GTGCCAGCTTCTGCATAGTCA	0.428000													39	131					0	0	0.006230	0	0
SCNN1G	6340	broad.mit.edu	37	16	23203737	23203737	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:23203737A>C	ENST00000300061.2	+	4	826	c.683A>C	c.(682-684)gAg>gCg	p.E228A		NM_001039.3	NP_001030.2	P51170	SCNNG_HUMAN	sodium channel, non-voltage-gated 1, gamma subunit	228					excretion|sensory perception of taste	apical plasma membrane|integral to plasma membrane	ligand-gated sodium channel activity|WW domain binding			NS(2)|autonomic_ganglia(1)|breast(1)|cervix(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	34				GBM - Glioblastoma multiforme(48;0.0366)	Amiloride(DB00594)|Triamterene(DB00384)	GCCATTCAGGAGTGGTATAAG	0.502000													36	48					0	0	0.004878	0	0
CCDC146	57639	broad.mit.edu	37	7	76871183	76871183	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:76871183G>A	ENST00000285871.4	+	4	542	c.415G>A	c.(415-417)Gaa>Aaa	p.E139K	CCDC146_ENST00000431197.1_5'UTR	NM_020879.2	NP_065930.2	Q8IYE0	CC146_HUMAN	coiled-coil domain containing 146	139										breast(3)|central_nervous_system(3)|endometrium(1)|kidney(4)|large_intestine(7)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	34		all_cancers(73;0.128)|all_lung(88;0.0986)|all_epithelial(88;0.163)|Myeloproliferative disorder(862;0.205)				TGCAGTGAAGGAAAGAGAGTT	0.373000													21	26					0	0	0.001882	0	0
NEB	4703	broad.mit.edu	37	2	152497159	152497159	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:152497159G>A	ENST00000397345.3	-	61	8597	c.8395C>T	c.(8395-8397)Cgt>Tgt	p.R2799C	NEB_ENST00000172853.10_Missense_Mutation_p.R2799C|NEB_ENST00000603639.1_Missense_Mutation_p.R2799C|NEB_ENST00000409198.1_Missense_Mutation_p.R2799C|NEB_ENST00000427231.2_Missense_Mutation_p.R2799C|NEB_ENST00000604864.1_Missense_Mutation_p.R2799C	NM_001164508.1	NP_001157980.1	P20929	NEBU_HUMAN	nebulin	2799					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			NS(5)|autonomic_ganglia(3)|breast(9)|central_nervous_system(5)|cervix(3)|endometrium(35)|kidney(16)|large_intestine(77)|liver(1)|lung(99)|ovary(9)|pancreas(3)|prostate(13)|skin(7)|stomach(8)|upper_aerodigestive_tract(6)|urinary_tract(2)	301				BRCA - Breast invasive adenocarcinoma(221;0.219)		AGCTGCTTACGATAGCCTTCT	0.433000													22	43					0	0	0.001882	0	0
VPS13C	54832	broad.mit.edu	37	15	62217698	62217698	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:62217698C>T	ENST00000261517.5	-	53	6639	c.6566G>A	c.(6565-6567)gGa>gAa	p.G2189E	VPS13C_ENST00000395896.4_Missense_Mutation_p.G2189E|VPS13C_ENST00000249837.3_Missense_Mutation_p.G2146E|VPS13C_ENST00000395898.3_Missense_Mutation_p.G2146E	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	2189					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						ATTTTGCTTTCCTGAAGCCCA	0.284000													3	6					0	0	0.004672	0	0
MYOCD	93649	broad.mit.edu	37	17	12647617	12647617	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:12647617C>T	ENST00000425538.1	+	8	1035	c.835C>T	c.(835-837)Cct>Tct	p.P279S	MYOCD_ENST00000343344.4_Missense_Mutation_p.P279S|MYOCD_ENST00000395988.1_Missense_Mutation_p.P183S	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	279					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		AGAGAAGTCCCCTCCACCTAT	0.557000													13	20					0	0	0.002450	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701519	56701519	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:56701519G>A	ENST00000586855.2	-	5	1478	c.1165C>T	c.(1165-1167)Cgg>Tgg	p.R389W	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.R389W			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	389					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						AAGCGCTTCCGACAGAGATCA	0.522000													23	42					0	0	0.001882	0	0
TEX2	55852	broad.mit.edu	37	17	62290858	62290858	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:62290858G>A	ENST00000258991.3	-	2	804	c.720C>T	c.(718-720)tcC>tcT	p.S240S	TEX2_ENST00000583097.1_Silent_p.S240S|TEX2_ENST00000584379.1_Silent_p.S240S			Q8IWB9	TEX2_HUMAN	testis expressed 2	240					signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		AGTTCAGTTTGGAATCAGGTG	0.507000													20	79					0	0	0.001523	0	0
GUCY1B3	2983	broad.mit.edu	37	4	156698722	156698722	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:156698722C>T	ENST00000264424.8	+	4	307	c.225C>T	c.(223-225)ttC>ttT	p.F75F	GUCY1B3_ENST00000513437.1_Silent_p.F7F|GUCY1B3_ENST00000507146.1_Silent_p.F7F|GUCY1B3_ENST00000503520.1_Silent_p.F75F|GUCY1B3_ENST00000505764.1_Silent_p.F55F|GUCY1B3_ENST00000502959.1_Silent_p.F75F|GUCY1B3_ENST00000505154.1_Silent_p.F7F	NM_000857.2	NP_000848.1	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	75					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		AGATGTTTTTCGTCTTTTGCC	0.353000													32	72					0	0	0.004878	0	0
CHL1	10752	broad.mit.edu	37	3	361522	361522	+	Silent	SNP	C	C	T	rs142096855		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:361522C>T	ENST00000256509.2	+	3	705	c.63C>T	c.(61-63)ttC>ttT	p.F21F	CHL1_ENST00000397491.2_Silent_p.F21F	NM_001253387.1|NM_001253388.1|NM_006614.3	NP_001240316.1|NP_001240317.1|NP_006605.2	O00533	CHL1_HUMAN	cell adhesion molecule L1-like	21					axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				NS(1)|central_nervous_system(5)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|lung(31)|ovary(1)|prostate(4)|skin(10)|stomach(1)	93		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TGTTAAAATTCTCAAAAGCAA	0.328000													16	32					0	0	0.007413	0	0
PDZD2	23037	broad.mit.edu	37	5	32000310	32000310	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:32000310C>T	ENST00000438447.1	+	5	1575	c.1187C>T	c.(1186-1188)tCc>tTc	p.S396F	PDZD2_ENST00000282493.3_Missense_Mutation_p.S396F			O15018	PDZD2_HUMAN	PDZ domain containing 2	396	PDZ 2.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						GTCGGGCTCTCCCACGAGGAA	0.532000													45	29					0	0	0.003610	0	0
FAM135B	51059	broad.mit.edu	37	8	139164516	139164516	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:139164516T>G	ENST00000395297.1	-	13	2372	c.2202A>C	c.(2200-2202)gaA>gaC	p.E734D		NM_015912.3	NP_056996.2	Q49AJ0	F135B_HUMAN	family with sequence similarity 135, member B	734										NS(3)|breast(9)|endometrium(21)|kidney(5)|large_intestine(28)|liver(1)|lung(135)|ovary(9)|pancreas(1)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(1)	238	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TTGTGTTACTTTCTGTGTGTC	0.532000										HNSCC(54;0.14)			6	65					0	0	0.001168	0	0
SLC36A1	206358	broad.mit.edu	37	5	150853240	150853240	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:150853240C>T	ENST00000243389.3	+	8	953	c.730C>T	c.(730-732)Cca>Tca	p.P244S	SLC36A1_ENST00000520701.1_Missense_Mutation_p.P244S|SLC36A1_ENST00000521925.1_Missense_Mutation_p.P244S	NM_078483.2	NP_510968.2	Q7Z2H8	S36A1_HUMAN	solute carrier family 36 (proton/amino acid symporter), member 1	244					cellular nitrogen compound metabolic process|ion transport	endoplasmic reticulum|integral to membrane|lysosomal membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			endometrium(5)|kidney(9)|lung(8)|skin(2)|urinary_tract(1)	25		Medulloblastoma(196;0.091)|all_hematologic(541;0.103)|all_neural(839;0.138)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glycine(DB00145)|L-Alanine(DB00160)	TCAGAGGATCCCAGACCCCAG	0.448000													125	178					0	0	0.003610	0	0
PRKCG	5582	broad.mit.edu	37	19	54396328	54396328	+	Splice_Site	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54396328A>C	ENST00000263431.3	+	8	1190	c.909_splice	c.e8+1	p.E303_splice	PRKCG_ENST00000540413.1_Splice_Site_p.E303_splice|PRKCG_ENST00000536044.1_Intron|PRKCG_ENST00000542049.1_Splice_Site_p.E190_splice	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	303					activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		CAGAAGTTTGAGGTACCCAGA	0.597000													8	23					0	0	0.003080	0	0
DNAH7	56171	broad.mit.edu	37	2	196765209	196765209	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:196765209G>A	ENST00000312428.6	-	28	4445	c.4345C>T	c.(4345-4347)Cgg>Tgg	p.R1449W		NM_018897.2	NP_061720.2	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1449	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(4)|breast(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(15)|large_intestine(28)|liver(3)|lung(100)|ovary(4)|prostate(5)|skin(26)|upper_aerodigestive_tract(2)|urinary_tract(3)	205						GCTACTGTCCGAAAGAGAGCC	0.398000													32	44					0	0	0.001786	0	0
SIGLEC12	89858	broad.mit.edu	37	19	52003419	52003419	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:52003419C>T	ENST00000291707.3	-	2	618	c.563G>A	c.(562-564)gGa>gAa	p.G188E	SIGLEC12_ENST00000598614.1_Missense_Mutation_p.G70E	NM_053003.2	NP_443729.1	Q96PQ1	SIG12_HUMAN	sialic acid binding Ig-like lectin 12 (gene/pseudogene)	188	Ig-like V-type 2.				cell adhesion	integral to membrane	sugar binding			NS(2)|biliary_tract(1)|breast(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(8)|liver(1)|lung(23)|ovary(4)|prostate(2)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)	61		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.0102)		GAACCAGGATCCATAAACAGG	0.542000													29	59					0	0	0.002445	0	0
SP100	6672	broad.mit.edu	37	2	231380341	231380341	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:231380341G>A	ENST00000264052.5	+	25	2981	c.2626G>A	c.(2626-2628)Gat>Aat	p.D876N	SP100_ENST00000340126.4_Intron	NM_003113.3	NP_003104.2	P23497	SP100_HUMAN	SP100 nuclear antigen	876					DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(4)|upper_aerodigestive_tract(1)	25		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		aaatgaagaagatgaTGATAA	0.338000													9	6					0	0	0.004482	0	0
AGMO	392636	broad.mit.edu	37	7	15240949	15240949	+	Silent	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:15240949A>G	ENST00000342526.3	-	13	1468	c.1299T>C	c.(1297-1299)gtT>gtC	p.V433V		NM_001004320.1	NP_001004320.1	Q6ZNB7	ALKMO_HUMAN	alkylglycerol monooxygenase	433					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding			breast(1)|kidney(1)|large_intestine(6)|liver(1)|lung(30)|prostate(1)|skin(2)	42						TCATGCTTCTAACTCCCCAGA	0.333000													40	50					0	0	0.003610	0	0
DSG3	1830	broad.mit.edu	37	18	29054213	29054213	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:29054213G>A	ENST00000257189.4	+	15	2314	c.2231G>A	c.(2230-2232)gGa>gAa	p.G744E		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	744					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			ACAGTGTCAGGAGCTGCTTCA	0.537000													15	25					0	0	0.002450	0	0
OR10K2	391107	broad.mit.edu	37	1	158390485	158390485	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:158390485G>A	ENST00000314902.2	-	1	171	c.172C>T	c.(172-174)Ccc>Tcc	p.P58S		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	58					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					AAGTACATGGGGATATGAAGG	0.493000													65	97					0	0	0.003610	0	0
TRIM55	84675	broad.mit.edu	37	8	67040674	67040674	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:67040674G>A	ENST00000315962.4	+	2	677	c.304G>A	c.(304-306)Gaa>Aaa	p.E102K	TRIM55_ENST00000276573.7_Missense_Mutation_p.E102K|TRIM55_ENST00000350034.4_Missense_Mutation_p.E102K|TRIM55_ENST00000353317.5_Missense_Mutation_p.E102K	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	102				E -> G (in Ref. 2; CAC43019/CAC43020).		cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			CCTGCTGGTGGAAAATATCAT	0.468000													22	205					0	0	0.007291	0	0
SDK1	221935	broad.mit.edu	37	7	4277403	4277403	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:4277403G>A	ENST00000404826.2	+	42	6256	c.6117G>A	c.(6115-6117)aaG>aaA	p.K2039K	SDK1_ENST00000389531.3_Silent_p.K2019K|SDK1_ENST00000466611.1_3'UTR	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	2039					cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGAAGTATAAGAACTGCAGCA	0.592000													20	166					0	0	0.002780	0	0
GLTSCR1L	23506	broad.mit.edu	37	6	42832752	42832752	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:42832752C>T	ENST00000314073.5	+	13	2984	c.2808C>T	c.(2806-2808)ggC>ggT	p.G936G	GLTSCR1L_ENST00000394168.1_Silent_p.G936G					GLTSCR1-like																		GCTCTCCCGGCCCTGAGGGGC	0.537000													14	70					0	0	0.003163	0	0
ZNF606	80095	broad.mit.edu	37	19	58489799	58489799	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:58489799G>A	ENST00000341164.4	-	7	2869	c.2249C>T	c.(2248-2250)tCc>tTc	p.S750F	ZNF606_ENST00000536132.1_Missense_Mutation_p.S660F	NM_025027.3	NP_079303.2	Q8WXB4	ZN606_HUMAN	zinc finger protein 606	750					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)		AATAATAAGGGAAGAATTCTT	0.373000													51	85					0	0	0.003610	0	0
SC5D	6309	broad.mit.edu	37	11	121178097	121178097	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:121178097C>T	ENST00000264027.4	+	5	1150	c.776C>T	c.(775-777)tCc>tTc	p.S259F	SC5D_ENST00000392789.2_Missense_Mutation_p.S259F|SC5D_ENST00000534230.1_Intron	NM_006918.4	NP_008849.2			sterol-C5-desaturase																		AATCCTTCATCCTTTGAGGGG	0.413000													29	35					0	0	0.002445	0	0
AOAH	313	broad.mit.edu	37	7	36616207	36616207	+	Silent	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:36616207T>G	ENST00000431169.1	-	13	1294	c.994A>C	c.(994-996)Agg>Cgg	p.R332R	AOAH_ENST00000535891.1_Silent_p.R300R|AOAH_ENST00000538464.1_Silent_p.R54R|AOAH_ENST00000258749.5_Silent_p.R332R	NM_001177506.1	NP_001170977.1	P28039	AOAH_HUMAN	acyloxyacyl hydrolase (neutrophil)	332					inflammatory response|lipid metabolic process	extracellular region	acyloxyacyl hydrolase activity|lipoprotein lipase activity			NS(1)|autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(3)|lung(21)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	41						TGGTAGTCCCTGTGATTACAG	0.303000													38	68					0	0	0.006999	0	0
VANGL1	81839	broad.mit.edu	37	1	116206695	116206695	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:116206695C>T	ENST00000355485.2	+	4	889	c.618C>T	c.(616-618)gtC>gtT	p.V206V	VANGL1_ENST00000369509.1_Silent_p.V206V|VANGL1_ENST00000369510.3_Silent_p.V204V|VANGL1_ENST00000310260.3_Silent_p.V206V	NM_001172411.1|NM_138959.2	NP_001165882.1|NP_620409.1	Q8TAA9	VANG1_HUMAN	VANGL planar cell polarity protein 1	206					multicellular organismal development	integral to membrane	protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(2)|liver(2)|lung(13)|urinary_tract(1)	27	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TTTACGGGGTCCGCATTTTGG	0.517000													50	111					0	0	0.003610	0	0
NRROS	375387	broad.mit.edu	37	3	196386840	196386840	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:196386840G>A	ENST00000328557.4	+	3	529	c.326G>A	c.(325-327)aGc>aAc	p.S109N		NM_198565.1	NP_940967.1			negative regulator of reactive oxygen species																		CACCTGCGCAGCCTGGTCCTG	0.667000													12	14					0	0	0.001368	0	0
OR2L13	284521	broad.mit.edu	37	1	248263371	248263371	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:248263371G>A	ENST00000366478.2	+	3	1031	c.694G>A	c.(694-696)Ggg>Agg	p.G232R	OR2L13_ENST00000358120.2_Missense_Mutation_p.G232R	NM_175911.2	NP_787107.1	Q8N349	OR2LD_HUMAN	olfactory receptor, family 2, subfamily L, member 13	232					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(12)|lung(32)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	59	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0132)			CTCAAAGGAGGGGAGAAAAAA	0.433000													26	79					0	0	0.004656	0	0
NMUR1	10316	broad.mit.edu	37	2	232393698	232393698	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:232393698G>A	ENST00000305141.4	-	2	167	c.34C>T	c.(34-36)Cct>Tct	p.P12S		NM_006056.4	NP_006047.3	Q9HB89	NMUR1_HUMAN	neuromedin U receptor 1	12					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|calcium ion transport|calcium-mediated signaling|chloride transport|smooth muscle contraction	integral to plasma membrane|membrane fraction	neuromedin U receptor activity			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(12)|pancreas(1)|skin(1)	24		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;8.37e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0142)		AGGTCTCCAGGGAGGACAGAG	0.567000													6	10					0	0	0.003080	0	0
GTF3C1	2975	broad.mit.edu	37	16	27476006	27476006	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:27476006G>A	ENST00000356183.4	-	34	5522	c.5507C>T	c.(5506-5508)cCc>cTc	p.P1836L	GTF3C1_ENST00000561623.1_Missense_Mutation_p.P1836L	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1836						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						CCCCTCCAGGGGTCTGGCCTG	0.677000													15	51					0	0	0.007413	0	0
ARHGAP24	83478	broad.mit.edu	37	4	86916189	86916189	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:86916189G>A	ENST00000395184.1	+	9	1848	c.1382G>A	c.(1381-1383)aGg>aAg	p.R461K	ARHGAP24_ENST00000264343.4_Missense_Mutation_p.R368K|ARHGAP24_ENST00000395183.2_Missense_Mutation_p.R366K	NM_001025616.2	NP_001020787.2	Q8N264	RHG24_HUMAN	Rho GTPase activating protein 24	461					angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell projection|cytoskeleton|cytosol|focal adhesion	GTPase activator activity|protein binding			breast(3)|cervix(1)|endometrium(3)|large_intestine(4)|lung(10)|skin(1)|stomach(1)|urinary_tract(1)	24		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.000571)		CAGGCCAGAAGGAGCTCTTCA	0.517000													18	13					0	0	0.004990	0	0
MOV10L1	54456	broad.mit.edu	37	22	50580509	50580509	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:50580509G>A	ENST00000262794.5	+	16	2153		c.e16-1		MOV10L1_ENST00000540615.1_Splice_Site|MOV10L1_ENST00000395858.3_Splice_Site|MOV10L1_ENST00000545383.1_Splice_Site|MOV10L1_ENST00000395843.1_Splice_Site	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)						germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		ATAATTTCTAGAATAGGAAAA	0.428000													87	61					0	0	0.003610	0	0
TBC1D8	11138	broad.mit.edu	37	2	101670590	101670590	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:101670590G>A	ENST00000409318.1	-	4	741	c.611C>T	c.(610-612)tCc>tTc	p.S204F	TBC1D8_ENST00000376840.4_Missense_Mutation_p.S189F	NM_001102426.1	NP_001095896.1	O95759	TBCD8_HUMAN	TBC1 domain family, member 8 (with GRAM domain)	189	GRAM 1.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			breast(1)|cervix(1)|endometrium(8)|kidney(3)|large_intestine(2)|lung(12)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	32						CAGGAAGAAGGAGTAGAAGCA	0.597000													6	6					0	0	0.001168	0	0
NAV3	89795	broad.mit.edu	37	12	78516075	78516075	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:78516075C>T	ENST00000397909.2	+	16	4278	c.4105C>T	c.(4105-4107)Ctc>Ttc	p.L1369F	NAV3_ENST00000228327.6_Missense_Mutation_p.L1369F|NAV3_ENST00000536525.2_Missense_Mutation_p.L1369F|NAV3_ENST00000266692.7_Intron			Q8IVL0	NAV3_HUMAN	neuron navigator 3	1369	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CATGACTAGCCTCCACACGAG	0.567000										HNSCC(70;0.22)			31	48					0	0	0.001786	0	0
WDR91	29062	broad.mit.edu	37	7	134889048	134889048	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:134889048G>A	ENST00000354475.4	-	6	894	c.863C>T	c.(862-864)tCg>tTg	p.S288L	WDR91_ENST00000485942.1_5'UTR|WDR91_ENST00000423565.1_Missense_Mutation_p.S253L|WDR91_ENST00000344400.5_Missense_Mutation_p.S288L	NM_014149.3	NP_054868.3	A4D1P6	WDR91_HUMAN	WD repeat domain 91	288										breast(3)|endometrium(2)|kidney(2)|large_intestine(12)|lung(14)|ovary(1)|pancreas(1)|skin(3)|upper_aerodigestive_tract(2)	40						TTTCTTGGCCGAGCTCTGAGG	0.592000													15	27					0	0	0.006122	0	0
LIPF	8513	broad.mit.edu	37	10	90436022	90436022	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:90436022G>A	ENST00000394375.3	+	10	1088	c.975G>A	c.(973-975)agG>agA	p.R325R	LIPF_ENST00000355843.2_Silent_p.R282R|LIPF_ENST00000496797.1_3'UTR|LIPF_ENST00000238983.4_Silent_p.R315R	NM_001198829.1	NP_001185758.1	P07098	LIPG_HUMAN	lipase, gastric	315					lipid catabolic process|triglyceride metabolic process	extracellular region	lipid binding|triglyceride lipase activity			NS(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(6)	13		Colorectal(252;0.0161)		Colorectal(12;3.91e-05)|COAD - Colon adenocarcinoma(12;5.43e-05)		TTCAGAATAGGATGCACTATG	0.303000													16	19					0	0	0.007413	0	0
FLT1	2321	broad.mit.edu	37	13	29012445	29012445	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:29012445G>A	ENST00000282397.4	-	4	677	c.426C>T	c.(424-426)atC>atT	p.I142I	FLT1_ENST00000541932.1_Silent_p.I142I|FLT1_ENST00000539099.1_Silent_p.I142I	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	142					cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	TAATTTCGGGGATTTCACTGT	0.373000													9	26					0	0	0.000673	0	0
ADARB1	104	broad.mit.edu	37	21	46596181	46596181	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:46596181C>T	ENST00000539173.1	+	4	1000	c.565C>T	c.(565-567)Ccc>Tcc	p.P189S	ADARB1_ENST00000437626.1_Intron|ADARB1_ENST00000389863.4_Missense_Mutation_p.P189S|ADARB1_ENST00000348831.4_Missense_Mutation_p.P189S|ADARB1_ENST00000360697.3_Missense_Mutation_p.P189S	NM_015833.3	NP_056648.1	P78563	RED1_HUMAN	adenosine deaminase, RNA-specific, B1	189					adenosine to inosine editing|mRNA modification|mRNA processing|RNA processing	nucleoplasm|nucleus	double-stranded RNA adenosine deaminase activity|double-stranded RNA binding|metal ion binding|mRNA binding|RNA binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(8)|skin(1)	17				Colorectal(79;0.115)		GGCGGAGCCTCCCTTTTACGT	0.592000													12	20					0	0	0.001368	0	0
DOCK3	1795	broad.mit.edu	37	3	51297628	51297628	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:51297628C>T	ENST00000266037.9	+	23	2249	c.2226C>T	c.(2224-2226)atC>atT	p.I742I		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	742						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		AGTCACGGATCCTGTACTCAC	0.463000													13	19					0	0	0.003163	0	0
PRKCG	5582	broad.mit.edu	37	19	54386423	54386423	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54386423C>T	ENST00000263431.3	+	2	459	c.177C>T	c.(175-177)atC>atT	p.I59I	PRKCG_ENST00000540413.1_Silent_p.I59I|PRKCG_ENST00000536044.1_Silent_p.I59I	NM_002739.3	NP_002730.1	P05129	KPCG_HUMAN	protein kinase C, gamma	59					activation of phospholipase C activity|cell death|intracellular signal transduction|negative regulation of protein catabolic process|negative regulation of protein ubiquitination|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of mismatch repair|synaptic transmission	cytosol	ATP binding|protein kinase C activity|zinc ion binding			large_intestine(1)|lung(4)|ovary(2)|pancreas(2)|skin(1)	10	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0521)		CCAGGGGTATCGGAAAGCAGG	0.647000													22	51					0	0	0.006320	0	0
DKK3	27122	broad.mit.edu	37	11	12023884	12023884	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:12023884C>T	ENST00000396505.2	-	3	552	c.314G>A	c.(313-315)gGa>gAa	p.G105E	DKK3_ENST00000525493.1_Missense_Mutation_p.G105E|DKK3_ENST00000450094.2_Missense_Mutation_p.G105E|DKK3_ENST00000326932.4_Missense_Mutation_p.G105E|DKK3_ENST00000527132.1_Intron	NM_015881.5	NP_056965.3	Q9UBP4	DKK3_HUMAN	dickkopf WNT signaling pathway inhibitor 3	105					adrenal gland development|anatomical structure morphogenesis|negative regulation of aldosterone biosynthetic process|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cortisol biosynthetic process|negative regulation of transcription, DNA-dependent|Wnt receptor signaling pathway	extracellular space		p.G105A(1)		breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|pancreas(1)	8				Epithelial(150;0.000502)		GGTATTATTTCCAACCTTCGT	0.463000													22	28					0	0	0.002299	0	0
FREM2	341640	broad.mit.edu	37	13	39425898	39425898	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:39425898G>C	ENST00000280481.7	+	11	7034	c.6818G>C	c.(6817-6819)aGa>aCa	p.R2273T		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	2273	Calx-beta 5.				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GTGGTTATAAGAATTCCAGTG	0.443000													28	21					0	0	0.007291	0	0
APRT	353	broad.mit.edu	37	16	88876248	88876248	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:88876248C>T	ENST00000378364.3	-	5	445	c.400_splice	c.e5-1	p.G134_splice	APRT_ENST00000426324.2_Intron|APRT_ENST00000563655.1_Splice_Site_p.G107_splice	NM_000485.2	NP_000476.1	P07741	APT_HUMAN	adenine phosphoribosyltransferase	134					purine ribonucleoside salvage	cytosol|nucleus	adenine phosphoribosyltransferase activity|AMP binding|protein binding			cervix(1)|endometrium(1)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(80;0.0477)	Adenine(DB00173)|Adenosine monophosphate(DB00131)	GTTCATGGTTCCTGGGGATGG	0.667000													6	21					0	0	0.001168	0	0
WNT9B	7484	broad.mit.edu	37	17	44953631	44953631	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:44953631G>A	ENST00000393461.2	+	4	674	c.621G>A	c.(619-621)agG>agA	p.R207R	WNT9B_ENST00000290015.2_Silent_p.R207R			O14905	WNT9B_HUMAN	wingless-type MMTV integration site family, member 9B	207					anterior/posterior pattern formation|axis specification|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|collecting duct development|cornea development in camera-type eye|endoderm development|establishment of planar polarity involved in nephron morphogenesis|kidney rudiment formation|male genitalia development|mesonephric duct formation|metanephric tubule development|neuron differentiation|palate development|regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|uterus morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway|Wnt receptor signaling pathway, planar cell polarity pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|G-protein-coupled receptor binding			large_intestine(2)|lung(8)	10			BRCA - Breast invasive adenocarcinoma(9;0.0257)			GTGGCCTCAGGACCACGTGTA	0.657000													10	19					0	0	0.006214	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560015	44560015	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:44560015G>A	ENST00000332567.4	-	1	1973	c.1621C>T	c.(1621-1623)Ccg>Tcg	p.P541S	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	541	Activation domain (By similarity).				regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						AGGGCGTCCGGATTGTTTCTA	0.597000													31	29					0	0	0.001512	0	0
PRC1	9055	broad.mit.edu	37	15	91512732	91512732	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:91512732G>A	ENST00000361188.5	-	13	2905	c.1694C>T	c.(1693-1695)cCc>cTc	p.P565L	PRC1_ENST00000361919.3_Intron|PRC1-AS1_ENST00000554388.1_RNA|PRC1_ENST00000394249.3_Missense_Mutation_p.P565L|PRC1_ENST00000442656.2_Intron|PRC1-AS1_ENST00000556200.1_RNA			O43663	PRC1_HUMAN	protein regulator of cytokinesis 1	565	Unstructured, Arg/Lys rich.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(3)|prostate(1)|skin(2)	25	Lung NSC(78;0.0987)|all_lung(78;0.175)					GCGCTGGAGGGGGGCCGAGCC	0.537000													149	250					0	0	0.003610	0	0
TNNT2	7139	broad.mit.edu	37	1	201334796	201334796	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:201334796G>A	ENST00000509001.1	-	8	492	c.206C>T	c.(205-207)tCg>tTg	p.S69L	TNNT2_ENST00000367315.2_Missense_Mutation_p.S69L|TNNT2_ENST00000367318.5_Missense_Mutation_p.S69L|TNNT2_ENST00000367320.2_Missense_Mutation_p.S78L|TNNT2_ENST00000367322.1_Missense_Mutation_p.S69L|TNNT2_ENST00000360372.4_Missense_Mutation_p.S64L|TNNT2_ENST00000458432.2_Missense_Mutation_p.S81L|TNNT2_ENST00000236918.7_Missense_Mutation_p.S74L|TNNT2_ENST00000421663.2_Missense_Mutation_p.S71L|TNNT2_ENST00000367317.4_Missense_Mutation_p.S69L	NM_001276347.1	NP_001263276.1	P45379	TNNT2_HUMAN	troponin T type 2 (cardiac)	79					ATP catabolic process|muscle filament sliding|negative regulation of ATPase activity|positive regulation of ATPase activity|regulation of heart contraction|response to calcium ion|ventricular cardiac muscle tissue morphogenesis	cytosol|troponin complex	actin binding|tropomyosin binding|troponin C binding|troponin I binding			breast(2)|cervix(1)|endometrium(3)|large_intestine(4)|liver(1)|lung(9)	20						GGGCATGAACGACCTGTTGGA	0.567000													26	16					0	0	0.006320	0	0
LMAN2L	81562	broad.mit.edu	37	2	97400219	97400219	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:97400219G>A	ENST00000264963.4	-	3	373	c.351C>T	c.(349-351)atC>atT	p.I117I	LMAN2L_ENST00000534882.1_5'UTR|LMAN2L_ENST00000377079.4_Silent_p.I117I|LMAN2L_ENST00000537039.1_5'UTR|LMAN2L_ENST00000426463.2_5'UTR	NM_030805.3	NP_110432.1	Q9H0V9	LMA2L_HUMAN	lectin, mannose-binding 2-like	117	L-type lectin-like.				ER to Golgi vesicle-mediated transport|protein folding|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle|Golgi membrane|integral to membrane	mannose binding|metal ion binding			NS(1)|breast(1)|endometrium(1)|lung(2)|skin(1)|urinary_tract(1)	7						CTTGTCCATGGATTTTGAAGT	0.463000													42	54					0	0	0.001951	0	0
CACNA1G	8913	broad.mit.edu	37	17	48674275	48674275	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:48674275G>A	ENST00000352832.5	+	15	3552	c.3180G>A	c.(3178-3180)atG>atA	p.M1060I	CACNA1G_ENST00000502264.1_Missense_Mutation_p.M1060I|CACNA1G_ENST00000513964.1_Missense_Mutation_p.M1083I|CACNA1G_ENST00000358244.5_Missense_Mutation_p.M1060I|CACNA1G_ENST00000416767.4_Missense_Mutation_p.M1083I|CACNA1G_ENST00000442258.2_Missense_Mutation_p.M1060I|CACNA1G_ENST00000359106.5_Missense_Mutation_p.M1083I|CACNA1G_ENST00000514181.1_Missense_Mutation_p.M1083I|CACNA1G_ENST00000512389.1_Missense_Mutation_p.M1083I|CACNA1G_ENST00000515165.1_Missense_Mutation_p.M1083I|CACNA1G_ENST00000429973.2_Missense_Mutation_p.M1083I|CACNA1G_ENST00000507336.1_Missense_Mutation_p.M1083I|CACNA1G_ENST00000514079.1_Missense_Mutation_p.M1083I|CACNA1G_ENST00000510115.1_Missense_Mutation_p.M1060I|CACNA1G_ENST00000507609.1_Missense_Mutation_p.M1083I|CACNA1G_ENST00000515411.1_Missense_Mutation_p.M1083I|CACNA1G_ENST00000507510.2_Missense_Mutation_p.M1083I|CACNA1G_ENST00000503485.1_Missense_Mutation_p.M1083I|CACNA1G_ENST00000513689.2_Missense_Mutation_p.M1083I|CACNA1G_ENST00000507896.1_Missense_Mutation_p.M1083I|CACNA1G_ENST00000354983.4_Missense_Mutation_p.M1060I|CACNA1G_ENST00000510366.1_Missense_Mutation_p.M1083I|CACNA1G_ENST00000515765.1_Missense_Mutation_p.M1083I|CACNA1G_ENST00000505165.1_Missense_Mutation_p.M1083I|CACNA1G_ENST00000514717.1_Missense_Mutation_p.M1060I|CACNA1G_ENST00000360761.4_Missense_Mutation_p.M1060I	NM_001256334.1|NM_198376.2|NM_198379.2|NM_198387.2|NM_198388.2	NP_001243263.1|NP_938190.1|NP_938193.1|NP_938201.1|NP_938202.1	O43497	CAC1G_HUMAN	calcium channel, voltage-dependent, T type, alpha 1G subunit	1083					axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(5)|cervix(1)|endometrium(13)|kidney(5)|lung(23)	47	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	CCCACGAGATGAAGTCACCGG	0.682000													3	3					0	0	0.004672	0	0
NPNT	255743	broad.mit.edu	37	4	106863686	106863686	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:106863686C>T	ENST00000379987.2	+	8	1202	c.986C>T	c.(985-987)cCa>cTa	p.P329L	NPNT_ENST00000305572.8_Missense_Mutation_p.P329L|NPNT_ENST00000453617.2_Missense_Mutation_p.P346L|NPNT_ENST00000427316.2_Missense_Mutation_p.P359L|NPNT_ENST00000506666.1_Missense_Mutation_p.P359L|NPNT_ENST00000514622.1_Missense_Mutation_p.P329L	NM_001033047.2	NP_001028219.1	Q6UXI9	NPNT_HUMAN	nephronectin	329	Pro-rich.				cell differentiation	membrane	calcium ion binding			kidney(5)|large_intestine(2)|lung(10)|prostate(2)|skin(1)|urinary_tract(1)	21		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.41e-07)		CCTACTCCACCACCACCACCA	0.517000													14	19					0	0	0.003163	0	0
RRN3P2	653390	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													5	50					0	0	0.001984	0	0
TGFBR3	7049	broad.mit.edu	37	1	92195499	92195499	+	Silent	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:92195499C>A	ENST00000212355.4	-	6	1065	c.600G>T	c.(598-600)ggG>ggT	p.G200G	TGFBR3_ENST00000370399.2_Silent_p.G200G|TGFBR3_ENST00000468996.2_5'UTR|TGFBR3_ENST00000525962.1_Silent_p.G200G	NM_001195683.1|NM_003243.4	NP_001182612.1|NP_003234.2	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	200					BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(24)|ovary(3)|prostate(4)|skin(1)|stomach(1)|urinary_tract(3)	55		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		GAAAATTCTTCCCTATGTTGC	0.478000													28	69					9.65021e-13	1.6453e-12	0.002096	1	0
DNAH9	1770	broad.mit.edu	37	17	11593583	11593583	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:11593583C>T	ENST00000262442.3	+	20	4512	c.4444C>T	c.(4444-4446)Ctg>Ttg	p.L1482L	DNAH9_ENST00000454412.2_Silent_p.L1482L	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	1482	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		ACTTCAGAACCTGGTGATGTC	0.507000													29	40					0	0	0.007291	0	0
RGAG4	340526	broad.mit.edu	37	X	71349749	71349749	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:71349749G>A	ENST00000545866.1	-	1	2009	c.1642C>T	c.(1642-1644)Cct>Tct	p.P548S	NHSL2_ENST00000540800.1_Intron|RGAG4_ENST00000479991.1_Missense_Mutation_p.P548S			Q5HYW3	RGAG4_HUMAN	retrotransposon gag domain containing 4	548										cervix(2)|endometrium(2)|kidney(3)|large_intestine(5)|lung(8)|ovary(3)|skin(1)	24	Renal(35;0.156)					AAAAGCACAGGGGGGCGTCTT	0.602000													25	2					0	0	0.003330	0	0
OGG1	4968	broad.mit.edu	37	3	9807638	9807638	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:9807638C>T	ENST00000302036.7	+	7	1437	c.1094C>T	c.(1093-1095)tCc>tTc	p.S365F	OGG1_ENST00000349503.5_Missense_Mutation_p.S298F|OGG1_ENST00000302008.8_3'UTR|OGG1_ENST00000383826.5_3'UTR|CAMK1_ENST00000256460.3_Intron|OGG1_ENST00000449570.2_3'UTR	NM_016821.2	NP_058214.1	O15527	OGG1_HUMAN	8-oxoguanine DNA glycosylase	0					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding			kidney(2)|large_intestine(2)|lung(2)|skin(1)|urinary_tract(1)	8	Medulloblastoma(99;0.227)					AGCCTCTCCTCCATTCCCTAT	0.577000								Base excision repair (BER), DNA glycosylases					16	37					0	0	0.006122	0	0
TNN	63923	broad.mit.edu	37	1	175049410	175049410	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:175049410G>A	ENST00000239462.4	+	4	1009	c.896G>A	c.(895-897)gGg>gAg	p.G299E		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	299	Fibronectin type-III 1.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TACCCCCTGGGGAAGGAGCTC	0.577000													16	74					0	0	0.006122	0	0
R3HDM2	22864	broad.mit.edu	37	12	57663588	57663588	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:57663588G>A	ENST00000402412.1	-	15	1924	c.1534C>T	c.(1534-1536)Cca>Tca	p.P512S	R3HDM2_ENST00000347140.3_Missense_Mutation_p.P498S|R3HDM2_ENST00000393811.2_Missense_Mutation_p.P225S|R3HDM2_ENST00000441731.2_Missense_Mutation_p.P193S|R3HDM2_ENST00000358907.2_Missense_Mutation_p.P498S|R3HDM2_ENST00000413953.2_Missense_Mutation_p.P225S|RP11-123K3.4_ENST00000548184.1_RNA|R3HDM2_ENST00000403821.2_Missense_Mutation_p.P532S			Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	498	Gln-rich.					nucleus	nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	22						TGAGTAGGTGGTGCATGGCTA	0.547000													21	48					0	0	0.001882	0	0
SCN11A	11280	broad.mit.edu	37	3	38888977	38888977	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:38888977G>A	ENST00000302328.3	-	26	4782	c.4584C>T	c.(4582-4584)atC>atT	p.I1528I	SCN11A_ENST00000450244.1_Silent_p.I1528I|SCN11A_ENST00000456224.3_Silent_p.I1490I	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1528					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	ATATGTCATCGATTCCAGACT	0.443000													14	30					0	0	0.004990	0	0
DMRTA2	63950	broad.mit.edu	37	1	50884876	50884876	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:50884876G>A	ENST00000404795.3	-	3	1482	c.1090C>T	c.(1090-1092)Cct>Tct	p.P364S	DMRTA2_ENST00000418121.1_Missense_Mutation_p.P364S	NM_032110.2	NP_115486.1	Q96SC8	DMTA2_HUMAN	DMRT-like family A2	364	Ala-rich.				sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|lung(4)|pancreas(1)	6						GGCGCCGCAGGGCCCAGGCCG	0.776000													3	2					0	0	0.004672	0	0
LMX1A	4009	broad.mit.edu	37	1	165175183	165175183	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:165175183G>A	ENST00000342310.3	-	8	1288	c.906C>T	c.(904-906)atC>atT	p.I302I	LMX1A_ENST00000294816.2_Silent_p.I302I|LMX1A_ENST00000367893.4_Silent_p.I302I|LMX1A_ENST00000489443.2_5'UTR	NM_177398.3	NP_796372.1	Q8TE12	LMX1A_HUMAN	LIM homeobox transcription factor 1, alpha	302						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|central_nervous_system(3)|cervix(2)|endometrium(4)|large_intestine(6)|lung(10)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(4)	35	all_hematologic(923;0.248)					CACTCTGCTCGATGGCCAGGA	0.577000													23	86					0	0	0.002299	0	0
PAX1	5075	broad.mit.edu	37	20	21689305	21689305	+	Silent	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:21689305A>G	ENST00000398485.2	+	3	1080	c.1026A>G	c.(1024-1026)aaA>aaG	p.K342K	PAX1_ENST00000460221.1_3'UTR|PAX1_ENST00000444366.2_Silent_p.K318K	NM_001257096.1|NM_006192.4	NP_001244025.1|NP_006183.2	P15863	PAX1_HUMAN	paired box 1	342					regulation of transcription, DNA-dependent|skeletal system development|transcription from RNA polymerase II promoter	nucleus	DNA binding			autonomic_ganglia(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(2)|lung(21)|prostate(3)|skin(1)|upper_aerodigestive_tract(3)	38						GGCTAGAGAAACCTGCCTTAG	0.582000													13	60					0	0	0.001855	0	0
SGPP2	130367	broad.mit.edu	37	2	223339404	223339404	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:223339404A>T	ENST00000321276.7	+	2	423	c.337A>T	c.(337-339)Att>Ttt	p.I113F		NM_152386.2	NP_689599.2	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphatase 2	113					sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	18		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		TCACTGGAATATTGACCCTTA	0.348000													20	31					0	0	0.001882	0	0
YEATS4	8089	broad.mit.edu	37	12	69756643	69756643	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:69756643C>T	ENST00000247843.2	+	2	397	c.127C>T	c.(127-129)Cac>Tac	p.H43Y	YEATS4_ENST00000548020.1_Missense_Mutation_p.H43Y	NM_006530.2	NP_006521.1	O95619	YETS4_HUMAN	YEATS domain containing 4	43	YEATS.				histone H2A acetylation|histone H4 acetylation|mitosis|positive regulation of transcription, DNA-dependent|regulation of growth	NuA4 histone acetyltransferase complex|nuclear matrix	DNA binding|protein C-terminus binding|sequence-specific DNA binding transcription factor activity|structural constituent of cytoskeleton			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(1)	5	all_epithelial(5;9.25e-35)|Breast(13;9.83e-07)|Esophageal squamous(21;0.187)		Epithelial(6;6.89e-18)|BRCA - Breast invasive adenocarcinoma(5;3.14e-09)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			AGAAGATGGGCACACTCATCA	0.318000													22	66					0	0	0.002299	0	0
GPR85	54329	broad.mit.edu	37	7	112724432	112724432	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:112724432G>C	ENST00000501255.2	-	3	968	c.345C>G	c.(343-345)atC>atG	p.I115M	GPR85_ENST00000424100.1_Missense_Mutation_p.I115M|GPR85_ENST00000297146.2_Missense_Mutation_p.I115M|GPR85_ENST00000449591.1_Missense_Mutation_p.I115M	NM_001146265.1|NM_001146266.1|NM_018970.6	NP_001139737.1|NP_001139738.1|NP_061843.3	P60893	GPR85_HUMAN	G protein-coupled receptor 85	115						integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(8)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	17						TGGTGACACTGATGCAGAAGA	0.468000													11	21					0	0	0.000673	0	0
DSC3	1825	broad.mit.edu	37	18	28598186	28598186	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:28598186C>T	ENST00000434452.1	-	9	1268	c.1114G>A	c.(1114-1116)Gaa>Aaa	p.E372K	DSC3_ENST00000360428.4_Missense_Mutation_p.E372K	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	372	Cadherin 3.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			CGTAAGATTTCCACATTGAAT	0.274000													10	30					0	0	0.006214	0	0
SLC16A12	387700	broad.mit.edu	37	10	91222222	91222222	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:91222222C>T	ENST00000341233.4	-	3	414	c.24G>A	c.(22-24)cgG>cgA	p.R8R	SLC16A12_ENST00000371790.4_Silent_p.R38R|RP11-168O10.6_ENST00000454270.1_RNA	NM_213606.3	NP_998771.3	Q6ZSM3	MOT12_HUMAN	solute carrier family 16, member 12	8						integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)|endometrium(1)|large_intestine(6)|lung(4)|skin(1)|stomach(1)	14						GGGAGGTAGACCGAGCTCTAT	0.478000													24	52					0	0	0.001512	0	0
ADAMTS1	9510	broad.mit.edu	37	21	28210437	28210437	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:28210437C>G	ENST00000284984.2	-	9	2819	c.2365G>C	c.(2365-2367)Gag>Cag	p.E789Q		NM_006988.3	NP_008919.3	Q9UHI8	ATS1_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 1	789	Spacer.				integrin-mediated signaling pathway|negative regulation of cell proliferation|proteolysis		heparin binding|zinc ion binding			central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(20)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	42		Breast(209;0.000962)		Lung(58;0.215)		ATGTCTTGCTCTAAGGTGGAC	0.483000													18	11					0	0	0.006122	0	0
ADCY7	113	broad.mit.edu	37	16	50339720	50339720	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:50339720C>T	ENST00000394697.2	+	14	2052	c.1712C>T	c.(1711-1713)aCc>aTc	p.T571I	ADCY7_ENST00000254235.3_Missense_Mutation_p.T571I|ADCY7_ENST00000537579.1_3'UTR|ADCY7_ENST00000538642.1_Missense_Mutation_p.T571I|ADCY7_ENST00000566433.2_Missense_Mutation_p.T571I			P51828	ADCY7_HUMAN	adenylate cyclase 7	571					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	GACTTCTACACCTTTGGGTCC	0.667000													14	23					0	0	0.004990	0	0
BPIFC	254240	broad.mit.edu	37	22	32853350	32853350	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:32853350G>A	ENST00000397452.1	-	2	134	c.24C>T	c.(22-24)gtC>gtT	p.V8V	BPIFC_ENST00000397450.1_Silent_p.V8V|BPIFC_ENST00000534972.1_5'UTR|BPIFC_ENST00000432451.2_5'UTR|BPIFC_ENST00000300399.3_Silent_p.V8V			Q8NFQ6	BPIL2_HUMAN	BPI fold containing family C	8						extracellular region	lipopolysaccharide binding|phospholipid binding										ATCCCCAGAGGACTGGGATTG	0.403000											OREG0003513	type=REGULATORY REGION|Gene=BPIL2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	25	38					0	0	0.004656	0	0
BTBD11	121551	broad.mit.edu	37	12	108051454	108051454	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:108051454C>T	ENST00000280758.5	+	17	3802	c.3274C>T	c.(3274-3276)Cag>Tag	p.Q1092*	BTBD11_ENST00000357167.4_Nonsense_Mutation_p.Q629*|BTBD11_ENST00000494235.2_Nonsense_Mutation_p.Q171*|BTBD11_ENST00000420571.2_Nonsense_Mutation_p.Q973*	NM_001018072.1	NP_001018082.1	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11	1092						integral to membrane	DNA binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(18)|ovary(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	53						CATCAGAATTCAGTCCATCCA	0.512000													30	73					0	0	0.002445	0	0
BOD1L1	259282	broad.mit.edu	37	4	13605633	13605633	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:13605633G>A	ENST00000040738.5	-	10	3026	c.2891C>T	c.(2890-2892)cCt>cTt	p.P964L		NM_148894.2	NP_683692.2	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division 1-like 1	964	Lys-rich.						DNA binding										TTCTTCAAAAGGTTTGTCTTC	0.408000													68	443					0	0	0.003610	0	0
KIAA0513	9764	broad.mit.edu	37	16	85111229	85111229	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:85111229G>A	ENST00000566428.1	+	6	1404	c.773G>A	c.(772-774)aGg>aAg	p.R258K	KIAA0513_ENST00000538274.1_Missense_Mutation_p.R258K|KIAA0513_ENST00000258180.3_Missense_Mutation_p.R258K|KIAA0513_ENST00000567328.1_Missense_Mutation_p.R258K			O60268	K0513_HUMAN	KIAA0513	258						cytoplasm				breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(9)|pancreas(1)	18				BRCA - Breast invasive adenocarcinoma(80;0.234)		CCCCTGGCCAGGAGGAACGAG	0.672000													13	31					0	0	0.001855	0	0
PFAS	5198	broad.mit.edu	37	17	8157260	8157260	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:8157260C>T	ENST00000314666.6	+	2	138	c.5C>T	c.(4-6)tCc>tTc	p.S2F	PFAS_ENST00000545834.1_5'UTR	NM_012393.2	NP_036525.1	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase	2					'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(2)|lung(9)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	35					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GCAGAGATGTCCCCAGTCCTT	0.522000													8	10					0	0	0.003080	0	0
FAM83B	222584	broad.mit.edu	37	6	54806377	54806377	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:54806377C>T	ENST00000306858.7	+	5	2724	c.2608C>T	c.(2608-2610)Cca>Tca	p.P870S		NM_001010872.1	NP_001010872.1	Q5T0W9	FA83B_HUMAN	family with sequence similarity 83, member B	870										autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(28)|ovary(6)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	71	Lung NSC(77;0.0178)|Renal(3;0.122)					AACACCTTCTCCAGGTCCAGT	0.433000													13	70					0	0	0.002450	0	0
CEACAM21	90273	broad.mit.edu	37	19	42085700	42085700	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:42085700C>T	ENST00000407170.2	+	4	848	c.35C>T	c.(34-36)tCc>tTc	p.S12F	CEACAM21_ENST00000482870.2_Intron|CEACAM21_ENST00000401445.2_Intron|CEACAM21_ENST00000187608.9_Intron			Q3KPI0	CEA21_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 21	0						integral to membrane				endometrium(2)|large_intestine(3)|lung(6)|ovary(1)|urinary_tract(1)	13						GTCACTCTATCCACAGAGTCA	0.502000													13	52					0	0	0.002450	0	0
CXCR1	3577	broad.mit.edu	37	2	219029795	219029795	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:219029795G>A	ENST00000295683.2	-	2	260	c.140C>T	c.(139-141)gCc>gTc	p.A47V		NM_000634.2	NP_000625.1	P25024	CXCR1_HUMAN	chemokine (C-X-C motif) receptor 1	47					dendritic cell chemotaxis|inflammatory response	integral to membrane|plasma membrane	interleukin-8 receptor activity			endometrium(1)|large_intestine(2)|lung(7)|prostate(3)	13						GAACACTAGGGCATAGGCGAT	0.507000													43	68					0	0	0.001951	0	0
VPS8	23355	broad.mit.edu	37	3	184632795	184632795	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:184632795C>T	ENST00000287546.4	+	26	2387	c.2216C>T	c.(2215-2217)cCc>cTc	p.P739L	VPS8_ENST00000437079.3_Missense_Mutation_p.P739L|VPS8_ENST00000446204.2_Missense_Mutation_p.P647L|VPS8_ENST00000436792.2_Missense_Mutation_p.P737L	NM_015303.3	NP_056118.2	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog (S. cerevisiae)	739							zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			CGTGCCTATCCCCTTGGTGAC	0.428000													19	82					0	0	0.001882	0	0
ZNF670	93474	broad.mit.edu	37	1	247200784	247200784	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:247200784G>A	ENST00000366503.2	-	4	1295	c.1137C>T	c.(1135-1137)tcC>tcT	p.S379S		NM_001204220.1|NM_033213.4	NP_001191149.1|NP_149990.1	Q9BS34	ZN670_HUMAN	zinc finger protein 670	379					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	17	all_cancers(71;4.01e-05)|all_epithelial(71;6.72e-06)|Ovarian(71;0.0173)|Breast(184;0.0318)|all_lung(81;0.0458)|Lung NSC(105;0.0518)	all_cancers(173;0.0266)	OV - Ovarian serous cystadenocarcinoma(106;0.00427)			GCTTTCGAAGGGAACTGGAAC	0.378000													29	76					0	0	0.007291	0	0
LRP1B	53353	broad.mit.edu	37	2	141092073	141092073	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:141092073C>T	ENST00000389484.3	-	79	13143	c.12172G>A	c.(12172-12174)Gat>Aat	p.D4058N		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	4058					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding	p.D4058Y(1)		NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		AGTGTACCATCCATGGCTGCT	0.438000										TSP Lung(27;0.18)			16	30					0	0	0.006122	0	0
CATSPERD	257062	broad.mit.edu	37	19	5746029	5746029	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:5746029C>T	ENST00000381624.3	+	9	824	c.763C>T	c.(763-765)Ctg>Ttg	p.L255L	CATSPERD_ENST00000381614.2_5'UTR	NM_152784.3	NP_689997.3	Q86XM0	TM146_HUMAN	catsper channel auxiliary subunit delta	255						integral to membrane											GAGAGGCATCCTGCTCCTATG	0.587000													69	64					0	0	0.003610	0	0
UBN1	29855	broad.mit.edu	37	16	4926972	4926972	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:4926972C>T	ENST00000396658.4	+	15	3828	c.3125C>T	c.(3124-3126)tCc>tTc	p.S1042F	UBN1_ENST00000262376.6_Missense_Mutation_p.S1042F|UBN1_ENST00000545171.1_Missense_Mutation_p.S1042F|UBN1_ENST00000590769.1_Missense_Mutation_p.S1042F	NM_016936.3	NP_058632.2	Q9NPG3	UBN1_HUMAN	ubinuclein 1	1042	Ser-rich.				chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						AGCTCGAACTCCTTGGGAATT	0.562000													40	75					0	0	0.003214	0	0
FBXO42	54455	broad.mit.edu	37	1	16577532	16577532	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:16577532C>T	ENST00000375592.3	-	10	2003	c.1787G>A	c.(1786-1788)gGa>gAa	p.G596E		NM_018994.1	NP_061867.1	Q6P3S6	FBX42_HUMAN	F-box protein 42	596										autonomic_ganglia(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	26		Colorectal(325;0.000147)|Renal(390;0.00145)|Breast(348;0.00224)|Lung NSC(340;0.00475)|all_lung(284;0.00671)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0193)|Colorectal(212;3.16e-07)|COAD - Colon adenocarcinoma(227;1.46e-05)|BRCA - Breast invasive adenocarcinoma(304;4.37e-05)|Kidney(64;0.000246)|KIRC - Kidney renal clear cell carcinoma(64;0.00336)|STAD - Stomach adenocarcinoma(313;0.0139)|READ - Rectum adenocarcinoma(331;0.0693)		CACTGTTTCTCCACTGCTCAA	0.607000													27	53					0	0	0.004656	0	0
APLNR	187	broad.mit.edu	37	11	57003372	57003372	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57003372G>A	ENST00000606794.1	-	1	1303	c.1107C>T	c.(1105-1107)tcC>tcT	p.S369S		NM_005161.4	NP_005152.1	P35414	APJ_HUMAN	apelin receptor	369						integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32						TGTAGGGGATGGATTTCTCGT	0.627000													14	58					0	0	0.004007	0	0
TCEB3B	51224	broad.mit.edu	37	18	44560546	44560546	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:44560546G>A	ENST00000332567.4	-	1	1442	c.1090C>T	c.(1090-1092)Ctc>Ttc	p.L364F	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron	NM_016427.2	NP_057511.2	Q8IYF1	ELOA2_HUMAN	transcription elongation factor B polypeptide 3B (elongin A2)	364					regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter	integral to membrane|nucleus	DNA binding			breast(1)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|lung(24)|ovary(2)|pancreas(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	58						ACCTCAGAGAGGGAGCTCACG	0.542000													31	35					0	0	0.002836	0	0
CRYBA4	1413	broad.mit.edu	37	22	27024309	27024309	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:27024309G>A	ENST00000354760.3	+	5	393	c.358G>A	c.(358-360)Gga>Aga	p.G120R	CRYBA4_ENST00000466315.1_3'UTR	NM_001886.2	NP_001877.1	P53673	CRBA4_HUMAN	crystallin, beta A4	120	Beta/gamma crystallin 'Greek key' 3.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens			large_intestine(6)|liver(1)|lung(6)|skin(3)|urinary_tract(2)	18						GGGCAAGAAAGGAGAGCTGAG	0.542000													24	37					0	0	0.003954	0	0
IQCJ-SCHIP1	100505385	broad.mit.edu	37	3	158980415	158980415	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:158980415C>T	ENST00000485419.1	+	4	403	c.234C>T	c.(232-234)tcC>tcT	p.S78S	IQCJ_ENST00000397832.2_Silent_p.S78S|IQCJ_ENST00000481796.1_3'UTR|IQCJ_ENST00000451172.1_Silent_p.S78S|IQCJ-SCHIP1_ENST00000476809.1_Silent_p.S51S|IQCJ_ENST00000482126.1_Silent_p.S51S|IQCJ-SCHIP1_ENST00000467442.1_3'UTR	NM_001197113.1	NP_001184042.1	Q9P0W5	SCHI1_HUMAN		0						cytoplasm	identical protein binding|protein binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(7)	12						CCTCTGTCTCCTCAGAGAAGC	0.527000													28	58					0	0	0.001512	0	0
THSD7A	221981	broad.mit.edu	37	7	11468645	11468645	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:11468645G>A	ENST00000423059.3	-	14	3423	c.3172C>T	c.(3172-3174)Cgt>Tgt	p.R1058C	AC004538.3_ENST00000445839.1_RNA	NM_015204.2	NP_056019.1	Q9UPZ6	THS7A_HUMAN	thrombospondin, type I, domain containing 7A	1058	TSP type-1 11.					integral to membrane				NS(1)|autonomic_ganglia(1)|breast(5)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(7)|lung(68)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(11)	113				UCEC - Uterine corpus endometrioid carcinoma (126;0.163)		CATTTAGAACGAACCTTCACA	0.512000										HNSCC(18;0.044)			48	174					0	0	0.003610	0	0
FHOD3	80206	broad.mit.edu	37	18	34335241	34335241	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:34335241G>A	ENST00000257209.4	+	22	3989	c.3867G>A	c.(3865-3867)gaG>gaA	p.E1289E	FHOD3_ENST00000359247.4_Silent_p.E1272E|FHOD3_ENST00000590592.1_Silent_p.E1464E|FHOD3_ENST00000445677.1_Silent_p.E1251E|FHOD3_ENST00000591635.1_Silent_p.E485E|FHOD3_ENST00000592128.1_Silent_p.E268E	NM_025135.2	NP_079411.2	Q2V2M9	FHOD3_HUMAN	formin homology 2 domain containing 3	1272					actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(25)|liver(2)|lung(29)|ovary(3)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)	90		all_epithelial(2;0.0181)|Colorectal(2;0.0195)				ACCACAGAGAGAGAAATAAGA	0.423000													7	8					0	0	0.003080	0	0
RPL8	6132	broad.mit.edu	37	8	146015848	146015848	+	Silent	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:146015848C>A	ENST00000262584.3	-	5	739	c.507G>T	c.(505-507)gtG>gtT	p.V169V	RPL8_ENST00000394920.2_Silent_p.V169V|RPL8_ENST00000528957.1_Silent_p.V169V|RPL8_ENST00000529163.1_5'UTR|RPL8_ENST00000527914.1_Silent_p.V60V	NM_000973.3	NP_000964.1	P62917	RL8_HUMAN	ribosomal protein L8	169					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	rRNA binding|structural constituent of ribosome			kidney(12)|lung(7)|prostate(1)	20	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;5.47e-39)|OV - Ovarian serous cystadenocarcinoma(54;6.38e-39)|all cancers(56;5.47e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.191)		CACCTCCAGCCACCACACCTG	0.577000													20	128					3.62473e-10	6.16659e-10	0.001882	1	0
TNXB	7148	broad.mit.edu	37	6	32065661	32065661	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32065661G>A	ENST00000375244.3	-	2	516	c.315C>T	c.(313-315)gtC>gtT	p.V105V	TNXB_ENST00000375247.2_Silent_p.V105V|TNXB_ENST00000479795.1_Silent_p.V105V			P22105	TENX_HUMAN	tenascin XB	105					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						TCTCTAGACGGACCCTCAGGG	0.612000													79	720					0	0	0.003610	0	0
ACTN1	87	broad.mit.edu	37	14	69341640	69341640	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:69341640G>A	ENST00000193403.6	-	21	2998	c.2615C>T	c.(2614-2616)tCc>tTc	p.S872F	ACTN1_ENST00000376839.3_Missense_Mutation_p.S802F|ACTN1_ENST00000438964.2_Missense_Mutation_p.S867F|ACTN1_ENST00000394419.4_Missense_Mutation_p.S894F|ACTN1_ENST00000538545.2_Missense_Mutation_p.S910F	NM_001102.3	NP_001093.1	P12814	ACTN1_HUMAN	actinin, alpha 1	872					focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(9)|prostate(2)|urinary_tract(1)	27				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		ACCTGGCACGGAGTCGGGGCC	0.662000													18	19					0	0	0.001216	0	0
CCR8	1237	broad.mit.edu	37	3	39374818	39374818	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:39374818G>A	ENST00000326306.4	+	2	1134	c.996G>A	c.(994-996)agG>agA	p.R332R	CCR8_ENST00000545843.1_Silent_p.R249R|CCR8_ENST00000414803.1_3'UTR	NM_005201.3	NP_005192.1	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	332					cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			NS(3)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|ovary(1)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		AAATGCCTAGGGAGAGCTGTG	0.418000													18	61					0	0	0.001216	0	0
PHACTR3	116154	broad.mit.edu	37	20	58330342	58330342	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:58330342G>A	ENST00000371015.1	+	4	931	c.464G>A	c.(463-465)gGa>gAa	p.G155E	PHACTR3_ENST00000395639.4_Missense_Mutation_p.G114E|PHACTR3_ENST00000361300.4_Missense_Mutation_p.G114E|PHACTR3_ENST00000355648.4_Missense_Mutation_p.G114E|PHACTR3_ENST00000541461.1_Missense_Mutation_p.G114E|PHACTR3_ENST00000359926.3_Missense_Mutation_p.G152E|PHACTR3_ENST00000395636.2_Missense_Mutation_p.G114E	NM_080672.3	NP_542403.1	Q96KR7	PHAR3_HUMAN	phosphatase and actin regulator 3	155						nuclear matrix	actin binding|protein phosphatase inhibitor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|liver(2)|lung(32)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	59	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;2.76e-09)			GCCCAGCCCGGAAGCCCCTTG	0.602000													8	22					0	0	0.004482	0	0
COL4A3	1285	broad.mit.edu	37	2	228162489	228162489	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:228162489G>A	ENST00000396578.3	+	42	3827	c.3665G>A	c.(3664-3666)gGa>gAa	p.G1222E	AC097662.2_ENST00000433324.1_RNA|AC097662.2_ENST00000439598.2_RNA|AC097662.2_ENST00000396588.2_RNA|COL4A3_ENST00000468753.1_3'UTR	NM_000091.4	NP_000082.2	Q01955	CO4A3_HUMAN	collagen, type IV, alpha 3 (Goodpasture antigen)	1222	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	55		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGCATAGAAGGATTCCCAGGG	0.602000													4	5					0	0	0.000248	0	0
EML5	161436	broad.mit.edu	37	14	89131692	89131692	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:89131692C>T	ENST00000554922.1	-	22	3514	c.3266G>A	c.(3265-3267)cGa>cAa	p.R1089Q	EML5_ENST00000352093.5_Missense_Mutation_p.R1051Q|EML5_ENST00000380664.5_Missense_Mutation_p.R1089Q	NM_183387.2	NP_899243.1	Q05BV3	EMAL5_HUMAN	echinoderm microtubule associated protein like 5	1089						cytoplasm|microtubule				breast(1)|endometrium(3)|kidney(4)|large_intestine(17)|lung(14)|ovary(3)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	50						AGGTGAAAATCGAATATCTGA	0.343000													8	11					0	0	0.003080	0	0
OR7D2	162998	broad.mit.edu	37	19	9297116	9297116	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9297116G>A	ENST00000344248.2	+	1	838	c.659G>A	c.(658-660)cGa>cAa	p.R220Q		NM_175883.2	NP_787079.1	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D, member 2	220					regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(2)|upper_aerodigestive_tract(2)	20						TCTTATTCACGAATTGCTTCA	0.463000													25	30					0	0	0.003954	0	0
ZNF205	7755	broad.mit.edu	37	16	3166463	3166463	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:3166463C>T	ENST00000382192.3	+	5	604	c.399C>T	c.(397-399)ctC>ctT	p.L133L	RP11-473M20.14_ENST00000575139.1_RNA|ZNF205_ENST00000219091.4_Silent_p.L133L|RP11-473M20.14_ENST00000576490.1_RNA	NM_001278158.1|NM_003456.2	NP_001265087.1|NP_003447.2	O95201	ZN205_HUMAN	zinc finger protein 205	133	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	20						CCTTGTACCTCTCCCGGGAGG	0.562000													17	23					0	0	0.001216	0	0
PM20D1	148811	broad.mit.edu	37	1	205817044	205817044	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:205817044G>A	ENST00000367136.4	-	2	269	c.225C>T	c.(223-225)gcC>gcT	p.A75A	PM20D1_ENST00000460624.1_5'UTR	NM_152491.4	NP_689704.4	Q6GTS8	P20D1_HUMAN	peptidase M20 domain containing 1	75						extracellular region	metal ion binding|peptidase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(9)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)	28	Breast(84;0.201)		BRCA - Breast invasive adenocarcinoma(75;0.0252)			ACTCAGCCAGGGCTGTAGTAT	0.423000													16	79					0	0	0.007413	0	0
TNFSF10	8743	broad.mit.edu	37	3	172224702	172224702	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:172224702C>T	ENST00000420541.2	-	3	368	c.278G>A	c.(277-279)aGa>aAa	p.R93K	TNFSF10_ENST00000241261.2_Silent_p.K142K	NM_001190942.1	NP_001177871.1	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily, member 10	0					activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			breast(2)|cervix(1)|large_intestine(1)|lung(6)|ovary(1)|skin(4)	15	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			CCTTTTCATTCTTGGAGTCTG	0.443000													9	17					0	0	0.004482	0	0
JAG1	182	broad.mit.edu	37	20	10629213	10629213	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:10629213G>A	ENST00000254958.5	-	12	2068	c.1553C>T	c.(1552-1554)tCt>tTt	p.S518F	JAG1_ENST00000423891.2_Missense_Mutation_p.S359F	NM_000214.2	NP_000205.1	P78504	JAG1_HUMAN	jagged 1	518	EGF-like 8; calcium-binding (Potential).				angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(14)|ovary(2)|pancreas(1)|urinary_tract(1)	44						GAGGTTTCCAGAGAAACCAGT	0.507000									Alagille Syndrome				16	59					0	0	0.001216	0	0
DNAJC5	80331	broad.mit.edu	37	20	62560684	62560684	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:62560684C>T	ENST00000360864.4	+	3	280	c.127C>T	c.(127-129)Cac>Tac	p.H43Y	DNAJC5_ENST00000369911.2_Missense_Mutation_p.H43Y	NM_025219.2	NP_079495.1	Q9H3Z4	DNJC5_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	43	J.				neurotransmitter secretion|protein folding	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|melanosome|plasma membrane	heat shock protein binding|unfolded protein binding			cervix(1)|endometrium(1)|lung(1)|pancreas(1)|upper_aerodigestive_tract(1)	5	all_cancers(38;2.14e-11)|all_epithelial(29;3.41e-13)|Lung NSC(23;3.41e-09)|all_lung(23;1.06e-08)					CTTGAAATATCACCCCGACAA	0.582000													7	21					0	0	0.001984	0	0
MARCO	8685	broad.mit.edu	37	2	119732008	119732008	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:119732008G>A	ENST00000541757.1	+	6	706	c.326G>A	c.(325-327)gGa>gAa	p.G109E	MARCO_ENST00000327097.4_Missense_Mutation_p.G187E			Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	187					cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(12)|lung(37)|ovary(4)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	70						GGACGAGATGGAGCAACAGGT	0.592000													10	10					0	0	0.006214	0	0
SIRT4	23409	broad.mit.edu	37	12	120741753	120741753	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:120741753C>T	ENST00000202967.4	+	2	448	c.389C>T	c.(388-390)aCc>aTc	p.T130I	SIRT4_ENST00000537892.1_3'UTR	NM_012240.2	NP_036372.1	Q9Y6E7	SIRT4_HUMAN	sirtuin 4	130	Deacetylase sirtuin-type.				chromatin silencing|negative regulation of insulin secretion|protein ADP-ribosylation|protein deacetylation	mitochondrial matrix	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides|NAD+ ADP-ribosyltransferase activity|NAD+ binding|protein binding|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(3)	9	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTTTGAGCACCTGGGAGAAA	0.597000													13	39					0	0	0.001368	0	0
ZC3H13	23091	broad.mit.edu	37	13	46544079	46544079	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:46544079A>G	ENST00000242848.4	-	14	2948	c.2600T>C	c.(2599-2601)gTt>gCt	p.V867A	ZC3H13_ENST00000282007.3_Missense_Mutation_p.V867A			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	867							nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		AGGTCGTACAACTTGGCTCAA	0.408000													30	47					0	0	0.007291	0	0
SLC5A9	200010	broad.mit.edu	37	1	48697266	48697266	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:48697266G>A	ENST00000236495.5	+	7	785	c.735G>A	c.(733-735)atG>atA	p.M245I	SLC5A9_ENST00000533824.1_Missense_Mutation_p.M241I|SLC5A9_ENST00000420136.2_3'UTR|SLC5A9_ENST00000438567.2_Missense_Mutation_p.M220I	NM_001135181.1	NP_001128653.1	Q2M3M2	SC5A9_HUMAN	solute carrier family 5 (sodium/sugar cotransporter), member 9	220						integral to membrane|plasma membrane	low-affinity glucose:sodium symporter activity			breast(1)|endometrium(3)|large_intestine(4)|liver(2)|lung(11)|ovary(3)|prostate(1)|urinary_tract(1)	26						CGGTGATCATGGTAGGGGGAG	0.542000													5	35					0	0	0.000602	0	0
KCNV1	27012	broad.mit.edu	37	8	110980497	110980497	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:110980497C>T	ENST00000524391.1	-	4	2355	c.1323G>A	c.(1321-1323)aaG>aaA	p.K441K	KCNV1_ENST00000297404.1_Silent_p.K441K			Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	441						voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(20)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			CAGCTGCTTCCTTGAGTTTCA	0.428000													37	65					0	0	0.004289	0	0
HELZ	9931	broad.mit.edu	37	17	65082989	65082989	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:65082989G>A	ENST00000358691.5	-	32	5616	c.5450C>T	c.(5449-5451)cCg>cTg	p.P1817L	HELZ_ENST00000580168.1_Missense_Mutation_p.P1818L	NM_014877.3	NP_055692.2			helicase with zinc finger											NS(1)|breast(5)|endometrium(9)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TCCATTGCACGGAATGTTCTG	0.473000													36	99					0	0	0.006230	0	0
CCDC64	92558	broad.mit.edu	37	12	120502557	120502557	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:120502557G>A	ENST00000397558.2	+	4	783	c.783G>A	c.(781-783)cgG>cgA	p.R261R	CCDC64_ENST00000446727.2_Silent_p.R5R	NM_207311.2	NP_997194.2	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	261					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|liver(2)|lung(4)|ovary(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	22	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGTCAGATCGGAAACGGGAGC	0.557000													44	94					0	0	0.002522	0	0
DDX60	55601	broad.mit.edu	37	4	169196545	169196545	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:169196545C>T	ENST00000393743.3	-	16	2546	c.2255G>A	c.(2254-2256)aGa>aAa	p.R752K		NM_017631.5	NP_060101.3	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	752							ATP binding|ATP-dependent helicase activity|RNA binding			breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(15)|liver(1)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|urinary_tract(4)	63		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TGGGTCTTTTCTCTCATCTCG	0.378000													25	30					0	0	0.003330	0	0
EXOSC10	5394	broad.mit.edu	37	1	11141286	11141286	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:11141286G>A	ENST00000544779.1	-	11	1295	c.1290C>T	c.(1288-1290)ccC>ccT	p.P430P	EXOSC10_ENST00000376936.4_Silent_p.P430P|EXOSC10_ENST00000304457.7_Silent_p.P430P|EXOSC10_ENST00000485606.1_5'UTR			Q01780	EXOSX_HUMAN	exosome component 10	430					CUT catabolic process|histone mRNA catabolic process|maturation of 5.8S rRNA|nuclear polyadenylation-dependent rRNA catabolic process|nuclear retention of unspliced pre-mRNA at the site of transcription|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasm|nuclear exosome (RNase complex)|nucleolus|transcriptionally active chromatin	3'-5' exonuclease activity|exoribonuclease activity|identical protein binding|nucleotide binding|protein serine/threonine kinase activity|RNA binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(9)|prostate(1)|stomach(3)|upper_aerodigestive_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;1.74e-05)|all_lung(284;2.05e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;4.18e-07)|COAD - Colon adenocarcinoma(227;8.33e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000315)|Kidney(185;0.000832)|KIRC - Kidney renal clear cell carcinoma(229;0.00269)|READ - Rectum adenocarcinoma(331;0.0526)|STAD - Stomach adenocarcinoma(313;0.202)		GCATCTCCTCGGGCAGAGGGC	0.532000													29	72					0	0	0.002096	0	0
GLB1	2720	broad.mit.edu	37	3	33038604	33038604	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:33038604G>A	ENST00000307363.5	-	16	2111	c.1967C>T	c.(1966-1968)cCt>cTt	p.P656L	GLB1_ENST00000399402.3_Missense_Mutation_p.P626L|GLB1_ENST00000307377.8_Missense_Mutation_p.P525L|GLB1_ENST00000445488.2_Missense_Mutation_p.P704L	NM_000404.2	NP_000395.2	P16278	BGAL_HUMAN	galactosidase, beta 1	656					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	21		Melanoma(143;0.104)				TTTTTCAACAGGTTTGGAGGG	0.493000													29	67					0	0	0.001512	0	0
DHX8	1659	broad.mit.edu	37	17	41599556	41599556	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:41599556C>T	ENST00000262415.3	+	22	3477	c.3405C>T	c.(3403-3405)atC>atT	p.I1135I	DHX8_ENST00000540306.1_Silent_p.I1135I	NM_004941.1	NP_004932.1	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	1135						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	42		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		TGGTCTATATCCATCCTTCCA	0.532000													21	47					0	0	0.002299	0	0
OR2J2	26707	broad.mit.edu	37	6	29142344	29142344	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:29142344G>A	ENST00000377167.2	+	1	1034	c.932G>A	c.(931-933)gGg>gAg	p.G311E		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	311					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						TGGGAGTGGGGGAAGTGACAG	0.423000													22	115					0	0	0.002299	0	0
DNASE1	1773	broad.mit.edu	37	16	3705913	3705913	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:3705913G>A	ENST00000246949.5	+	3	3420	c.211G>A	c.(211-213)Ggg>Agg	p.G71R	DNASE1_ENST00000407479.1_Missense_Mutation_p.G71R|DNASE1_ENST00000414110.2_Intron	NM_005223.3	NP_005214.2	P24855	DNAS1_HUMAN	deoxyribonuclease I	71					apoptosis|DNA catabolic process	extracellular region|nuclear envelope	actin binding|deoxyribonuclease I activity			lung(1)	1		Ovarian(90;0.0261)		Kidney(780;0.0556)	Dornase Alfa(DB00003)	GACTGCCGTGGGGAAGCTGCT	0.622000													22	25					0	0	0.005443	0	0
FAM171A1	221061	broad.mit.edu	37	10	15255082	15255082	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:15255082C>T	ENST00000378116.4	-	8	2511	c.2505G>A	c.(2503-2505)acG>acA	p.T835T		NM_001010924.1	NP_001010924.1	Q5VUB5	F1711_HUMAN	family with sequence similarity 171, member A1	835						integral to membrane				breast(6)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(20)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	52						TCCGTCTGGTCGTCTCCTCCT	0.637000													37	42					0	0	0.004878	0	0
TRPM3	80036	broad.mit.edu	37	9	73230967	73230967	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:73230967G>A	ENST00000377110.2	-	17	2590	c.2347C>T	c.(2347-2349)Cct>Tct	p.P783S	TRPM3_ENST00000377105.1_Missense_Mutation_p.P642S|TRPM3_ENST00000396285.1_Missense_Mutation_p.P630S|TRPM3_ENST00000396292.4_Missense_Mutation_p.P655S|TRPM3_ENST00000408909.2_Missense_Mutation_p.P642S|TRPM3_ENST00000423814.3_Missense_Mutation_p.P810S|TRPM3_ENST00000358082.3_Missense_Mutation_p.P645S|TRPM3_ENST00000357533.2_Missense_Mutation_p.P787S|TRPM3_ENST00000360823.2_Missense_Mutation_p.P645S|TRPM3_ENST00000377106.1_Missense_Mutation_p.P655S|TRPM3_ENST00000396280.5_Missense_Mutation_p.P632S|TRPM3_ENST00000377111.2_Missense_Mutation_p.P783S	NM_001007471.2	NP_001007472.2	Q9HCF6	TRPM3_HUMAN	transient receptor potential cation channel, subfamily M, member 3	808						integral to membrane	calcium channel activity			NS(2)|breast(4)|central_nervous_system(2)|endometrium(6)|kidney(1)|large_intestine(18)|liver(1)|lung(46)|ovary(3)|pancreas(2)|prostate(5)|skin(4)|urinary_tract(1)	95						AGAATTGAAGGAGGAAGTAGA	0.378000													7	21					0	0	0.001984	0	0
PRRT1	80863	broad.mit.edu	37	6	32118480	32118480	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32118480G>A	ENST00000211413.5	-	2	347	c.223C>T	c.(223-225)Ccc>Tcc	p.P75S	PRRT1_ENST00000375152.2_Intron|PRRT1_ENST00000375150.2_Intron	NM_030651.3	NP_085154.3	Q99946	PRRT1_HUMAN	proline-rich transmembrane protein 1	75					response to biotic stimulus	integral to membrane				breast(2)|endometrium(1)|kidney(1)|lung(2)	6						GAGGAGGAGGGACCGCGCTGA	0.751000													14	143					0	0	0.002450	0	0
XIRP1	165904	broad.mit.edu	37	3	39227497	39227497	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:39227497G>A	ENST00000340369.3	-	2	3668	c.3440C>T	c.(3439-3441)cCc>cTc	p.P1147L	XIRP1_ENST00000396251.1_Intron|XIRP1_ENST00000421646.1_Intron	NM_194293.2	NP_919269.2	Q702N8	XIRP1_HUMAN	xin actin-binding repeat containing 1	1147							actin binding			breast(4)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(14)|lung(22)|ovary(4)|pancreas(1)|prostate(2)|skin(6)	71				KIRC - Kidney renal clear cell carcinoma(284;0.0517)|Kidney(284;0.065)		GGTCCTCACGGGATGAGCGGT	0.622000													23	47					0	0	0.002780	0	0
SERPING1	710	broad.mit.edu	37	11	57367838	57367838	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57367838C>T	ENST00000403558.1	+	2	1006	c.640C>T	c.(640-642)Cag>Tag	p.Q214*	SERPING1_ENST00000278407.4_Nonsense_Mutation_p.Q180*|SERPING1_ENST00000340687.6_Nonsense_Mutation_p.Q180*|SERPING1_ENST00000378323.4_Nonsense_Mutation_p.Q185*|SERPING1_ENST00000378324.2_Nonsense_Mutation_p.Q128*	NM_001032295.1	NP_001027466.1	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G (C1 inhibitor), member 1	180					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(11)|pancreas(2)|prostate(1)|urinary_tract(1)	27						CCTCCTTACCCAGGTCCTGCT	0.512000													30	90					0	0	0.002445	0	0
CACNA1S	779	broad.mit.edu	37	1	201010696	201010696	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:201010696G>A	ENST00000362061.3	-	41	5296	c.5070C>T	c.(5068-5070)ttC>ttT	p.F1690F	CACNA1S_ENST00000367338.3_Silent_p.F1671F|RP11-168O16.2_ENST00000415359.1_RNA	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	1690					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TCTCTTCTGGGAACTCCCTTT	0.562000													23	11					0	0	0.005443	0	0
ELAVL2	1993	broad.mit.edu	37	9	23762245	23762245	+	Translation_Start_Site	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:23762245C>A	ENST00000397312.2	-	0	262				ELAVL2_ENST00000223951.6_De_novo_Start_OutOfFrame|ELAVL2_ENST00000544538.1_De_novo_Start_OutOfFrame|ELAVL2_ENST00000380117.1_Splice_Site|ELAVL2_ENST00000380110.4_Missense_Mutation_p.Q25H	NM_004432.3	NP_004423.2	Q12926	ELAV2_HUMAN	ELAV like neuron-specific RNA binding protein 2						regulation of transcription, DNA-dependent		mRNA 3'-UTR binding|nucleotide binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(20)|ovary(2)|skin(1)|stomach(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(1;2.18e-156)|Lung(42;2.15e-28)|LUSC - Lung squamous cell carcinoma(38;1.02e-19)		CAGCAATTACCTGCTAAAAAC	0.393000													71	54					3.98911e-17	6.813e-17	0.003610	1	0
HTT	3064	broad.mit.edu	37	4	3101017	3101017	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:3101017C>T	ENST00000355072.5	+	3	509	c.364C>T	c.(364-366)Cag>Tag	p.Q122*		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	122					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TCCAGAATTTCAGAAACTTCT	0.433000													82	80					0	0	0.003610	0	0
DEPDC5	9681	broad.mit.edu	37	22	32211046	32211046	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:32211046C>T	ENST00000400246.1	+	21	1656	c.1514C>T	c.(1513-1515)tCc>tTc	p.S505F	DEPDC5_ENST00000266091.3_Missense_Mutation_p.S505F|DEPDC5_ENST00000536766.1_Missense_Mutation_p.S477F|DEPDC5_ENST00000400248.1_Missense_Mutation_p.S505F|DEPDC5_ENST00000400242.3_Missense_Mutation_p.S505F|DEPDC5_ENST00000382111.2_Missense_Mutation_p.S505F|DEPDC5_ENST00000382105.2_Missense_Mutation_p.S505F|DEPDC5_ENST00000382112.3_Missense_Mutation_p.S505F|DEPDC5_ENST00000535622.1_Missense_Mutation_p.S505F|DEPDC5_ENST00000400249.2_Missense_Mutation_p.S505F			O75140	DEPD5_HUMAN	DEP domain containing 5	505					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						TCCAGCCCTTCCCTACCAAGC	0.552000													18	56					0	0	0.007413	0	0
DNAH1	25981	broad.mit.edu	37	3	52384572	52384572	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:52384572C>T	ENST00000420323.2	+	16	2956	c.2695C>T	c.(2695-2697)Ctc>Ttc	p.L899F		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	899	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GGATGAATTCCTCTACAACCT	0.562000													10	16					0	0	0.001368	0	0
GLRX3	10539	broad.mit.edu	37	10	131958313	131958313	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:131958313C>T	ENST00000368644.1	+	3	278	c.256C>T	c.(256-258)Ccc>Tcc	p.P86S	GLRX3_ENST00000331244.5_Missense_Mutation_p.P86S	NM_001199868.1	NP_001186797.1	O76003	GLRX3_HUMAN	glutaredoxin 3	86	Thioredoxin.				cell redox homeostasis|negative regulation of cardiac muscle hypertrophy|regulation of the force of heart contraction	cell cortex	electron carrier activity|iron-sulfur cluster binding|metal ion binding|protein disulfide oxidoreductase activity			endometrium(1)|large_intestine(5)|lung(7)	13		all_cancers(35;9.59e-07)|all_epithelial(44;1.48e-06)|Lung NSC(174;0.00566)|all_lung(145;0.00949)|Colorectal(57;0.142)|all_neural(114;0.16)|Breast(234;0.173)|Glioma(114;0.222)		OV - Ovarian serous cystadenocarcinoma(35;0.00218)		TAGCTCTGTTCCCACTTTTCT	0.358000													39	65					0	0	0.002522	0	0
ANTXR1	84168	broad.mit.edu	37	2	69397402	69397402	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:69397402C>T	ENST00000303714.4	+	14	1392	c.1070C>T	c.(1069-1071)cCc>cTc	p.P357L	ANTXR1_ENST00000409349.3_Missense_Mutation_p.P357L	NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	357					actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						GTCCCTCCACCCCCTGCCGAG	0.557000									Familial Infantile Hemangioma				11	32					0	0	0.000978	0	0
FAM13C	220965	broad.mit.edu	37	10	61022203	61022203	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:61022203C>T	ENST00000373867.3	-	11	1443	c.978G>A	c.(976-978)gaG>gaA	p.E326E	FAM13C_ENST00000419214.2_Intron|FAM13C_ENST00000277705.6_Silent_p.E430E|FAM13C_ENST00000435852.2_Silent_p.E409E|FAM13C_ENST00000442566.3_Silent_p.E430E|FAM13C_ENST00000468840.2_Silent_p.E326E|FAM13C_ENST00000422313.2_Silent_p.E409E|FAM13C_ENST00000373868.2_Silent_p.E409E	NM_001166698.1	NP_001160170.1	Q8NE31	FA13C_HUMAN	family with sequence similarity 13, member C	409										NS(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						CCTTAGAATCCTCCTGGGGAG	0.517000													13	17					0	0	0.004007	0	0
DSG3	1830	broad.mit.edu	37	18	29046600	29046600	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:29046600C>T	ENST00000257189.4	+	11	1602	c.1519C>T	c.(1519-1521)Cct>Tct	p.P507S		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	507					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CAGTTCTTCACCTTCCGTGGT	0.448000													35	55					0	0	0.003271	0	0
ANTXR1	84168	broad.mit.edu	37	2	69397403	69397403	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:69397403C>T	ENST00000303714.4	+	14	1393	c.1071C>T	c.(1069-1071)ccC>ccT	p.P357P	ANTXR1_ENST00000409349.3_Silent_p.P357P	NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	357					actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						TCCCTCCACCCCCTGCCGAGG	0.557000									Familial Infantile Hemangioma				11	32					0	0	0.000978	0	0
TYROBP	7305	broad.mit.edu	37	19	36398155	36398155	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:36398155T>C	ENST00000585901.2	-	4	352	c.334A>G	c.(334-336)Aaa>Gaa	p.K112E	TYROBP_ENST00000262629.4_Missense_Mutation_p.K81E|TYROBP_ENST00000424586.3_Missense_Mutation_p.K69E|TYROBP_ENST00000589517.1_Missense_Mutation_p.K80E|TYROBP_ENST00000544690.2_Missense_Mutation_p.K70E			O43914	TYOBP_HUMAN	TYRO protein tyrosine kinase binding protein	81					axon guidance|cell junction assembly|cellular defense response|intracellular signal transduction|regulation of immune response	integral to plasma membrane|intracellular	identical protein binding|receptor signaling protein activity			NS(1)|central_nervous_system(1)|large_intestine(1)|lung(4)|skin(1)	8	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			ATACGCTGTTTCCGGGTCGCT	0.542000													5	16					0	0	0.001168	0	0
CAPN13	92291	broad.mit.edu	37	2	30987150	30987150	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:30987150G>A	ENST00000295055.8	-	6	723	c.547C>T	c.(547-549)Ctg>Ttg	p.L183L	CAPN13_ENST00000465960.2_5'UTR|CAPN13_ENST00000534090.2_Silent_p.L183L	NM_144575.2	NP_653176.2	Q6MZZ7	CAN13_HUMAN	calpain 13	183	Calpain catalytic.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(1)	30	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					CCATAGTGCAGATCGGAATAG	0.582000													7	24					0	0	0.003080	0	0
VPS13C	54832	broad.mit.edu	37	15	62217696	62217696	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:62217696T>C	ENST00000261517.5	-	53	6641	c.6568A>G	c.(6568-6570)Aag>Gag	p.K2190E	VPS13C_ENST00000395896.4_Missense_Mutation_p.K2190E|VPS13C_ENST00000249837.3_Missense_Mutation_p.K2147E|VPS13C_ENST00000395898.3_Missense_Mutation_p.K2147E	NM_020821.2	NP_065872.1	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13 homolog C (S. cerevisiae)	2190					protein localization					NS(3)|breast(4)|endometrium(4)|kidney(9)|large_intestine(26)|lung(46)|ovary(5)|prostate(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	117						ATATTTTGCTTTCCTGAAGCC	0.284000													3	5					0	0	0.004672	0	0
CEACAM8	1088	broad.mit.edu	37	19	43093719	43093719	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:43093719C>T	ENST00000244336.5	-	3	694	c.593G>A	c.(592-594)aGg>aAg	p.R198K	CEACAM8_ENST00000599005.1_Intron|LIPE-AS1_ENST00000594688.1_RNA|LIPE-AS1_ENST00000594624.2_RNA	NM_001816.3	NP_001807.2	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion molecule 8	198	Ig-like C2-type 1.				immune response	anchored to membrane|extracellular space|integral to plasma membrane				endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|skin(1)	16		Prostate(69;0.00899)				AGTGAGGGTCCTGTTGCCATT	0.522000													54	87					0	0	0.003610	0	0
IARS	3376	broad.mit.edu	37	9	94984883	94984883	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:94984883C>T	ENST00000375643.3	-	33	3891	c.3625G>A	c.(3625-3627)Ggt>Agt	p.G1209S	IARS_ENST00000443024.2_Missense_Mutation_p.G1209S|IARS_ENST00000375629.3_3'UTR|IARS_ENST00000447699.2_Missense_Mutation_p.G1099S	NM_013417.2	NP_038203.2	P41252	SYIC_HUMAN	isoleucyl-tRNA synthetase	1209					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	35					L-Isoleucine(DB00167)	TACAGAAGACCTTGGTGGGTG	0.498000													73	102					0	0	0.003610	0	0
STAB2	55576	broad.mit.edu	37	12	104014257	104014257	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:104014257G>A	ENST00000388887.2	+	4	547	c.343G>A	c.(343-345)Gga>Aga	p.G115R		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	115	EGF-like 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						GTGCCCAGGTGGAGCGGGGTC	0.488000													5	8					0	0	0.001168	0	0
OR2A2	442361	broad.mit.edu	37	7	143807593	143807593	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:143807593G>A	ENST00000408979.2	+	1	987	c.918G>A	c.(916-918)agG>agA	p.R306R		NM_001005480.2	NP_001005480.2	Q6IF42	OR2A2_HUMAN	olfactory receptor, family 2, subfamily A, member 2	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(13)|prostate(1)|skin(4)	22	Melanoma(164;0.0783)					CACTCCAGAGGAAGAGGTCCA	0.433000													34	37					0	0	0.002836	0	0
EGR1	1958	broad.mit.edu	37	5	137803292	137803292	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:137803292C>T	ENST00000239938.4	+	2	1426	c.1154C>T	c.(1153-1155)aCc>aTc	p.T385I		NM_001964.2	NP_001955.1	P18146	EGR1_HUMAN	early growth response 1	385					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CACCTCACCACCCACATCCGC	0.602000													11	58					0	0	0.000978	0	0
SVEP1	79987	broad.mit.edu	37	9	113173765	113173765	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:113173765G>A	ENST00000401783.2	-	37	6562	c.6226C>T	c.(6226-6228)Ccc>Tcc	p.P2076S	SVEP1_ENST00000297826.5_Missense_Mutation_p.P2S|SVEP1_ENST00000374469.1_Missense_Mutation_p.P2053S	NM_153366.3	NP_699197.3	Q4LDE5	SVEP1_HUMAN	sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1	2076	Sushi 11.				cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						ATACAACGGGGCATGTCTTGA	0.483000													23	2					0	0	0.001882	0	0
PCDHA6	56142	broad.mit.edu	37	5	140208798	140208798	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140208798G>A	ENST00000529310.1	+	1	1236	c.1122G>A	c.(1120-1122)gtG>gtA	p.V374V	PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000527624.1_Silent_p.V374V|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron	NM_018909.2|NM_031848.1|NM_031849.1	NP_061732.1|NP_114036.1|NP_114037.1														NS(1)|breast(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(42)|prostate(8)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	89			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAATTAGCGTGAACGACCTCG	0.498000													81	111					0	0	0.003610	0	0
TTBK1	84630	broad.mit.edu	37	6	43226884	43226884	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43226884C>T	ENST00000259750.4	+	11	1208	c.1125C>T	c.(1123-1125)ccC>ccT	p.P375P	TTBK1_ENST00000304139.5_Silent_p.P324P	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	375						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CAATTCTGCCCGGGAGGCCCT	0.647000													19	104					0	0	0.001882	0	0
OR2J2	26707	broad.mit.edu	37	6	29141898	29141898	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:29141898C>T	ENST00000377167.2	+	1	588	c.486C>T	c.(484-486)tcC>tcT	p.S162S		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	162					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						TTCATTCCTCCTTTACTTTCT	0.468000													61	430					0	0	0.003610	0	0
FSCN1	6624	broad.mit.edu	37	7	5633104	5633104	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:5633104C>T	ENST00000382361.3	+	1	651	c.537C>T	c.(535-537)ctC>ctT	p.L179L	FSCN1_ENST00000340250.6_Silent_p.L158L	NM_003088.3	NP_003079.1	Q16658	FSCN1_HUMAN	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	179					actin filament bundle assembly|cell migration|cell proliferation	cell junction|cytoplasm|filopodium|invadopodium|stress fiber	actin filament binding|drug binding|protein binding, bridging			central_nervous_system(1)|kidney(3)|large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	9		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;1.21e-13)		TCATCACCCTCGCCTTCCAGG	0.736000													23	92					0	0	0.003954	0	0
ZNF211	10520	broad.mit.edu	37	19	58152834	58152834	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:58152834G>A	ENST00000544273.1	+	5	1343	c.1016G>A	c.(1015-1017)aGc>aAc	p.S339N	ZNF211_ENST00000541801.1_Missense_Mutation_p.S318N|ZNF211_ENST00000391703.3_Missense_Mutation_p.S266N|ZNF211_ENST00000347302.3_Missense_Mutation_p.S327N|ZNF211_ENST00000254182.7_Missense_Mutation_p.S318N|ZNF211_ENST00000420680.1_Missense_Mutation_p.S331N|ZNF211_ENST00000299871.5_Missense_Mutation_p.S392N|ZNF211_ENST00000240731.4_Missense_Mutation_p.S340N			Q13398	ZN211_HUMAN	zinc finger protein 211	327						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	26		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CAGATATACAGCCTCAATAGC	0.438000													8	34					0	0	0.004482	0	0
SGMS2	166929	broad.mit.edu	37	4	108817049	108817049	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:108817049C>T	ENST00000394684.4	+	3	897	c.340C>T	c.(340-342)Cca>Tca	p.P114S	SGMS2_ENST00000394686.3_Missense_Mutation_p.P114S|RP11-286E11.1_ENST00000499098.1_RNA|RP11-286E11.1_ENST00000513071.1_RNA|SGMS2_ENST00000359079.4_Missense_Mutation_p.P114S	NM_001136258.1	NP_001129730.1	Q8NHU3	SMS2_HUMAN	sphingomyelin synthase 2	114					sphingomyelin biosynthetic process	integral to Golgi membrane|integral to plasma membrane	ceramide cholinephosphotransferase activity|kinase activity|sphingomyelin synthase activity			central_nervous_system(1)|endometrium(2)|large_intestine(8)|liver(2)|lung(6)|prostate(1)	20				OV - Ovarian serous cystadenocarcinoma(123;2.95e-05)	Choline(DB00122)	CCCTCCACTCCCAGACAAGTT	0.423000													15	47					0	0	0.004007	0	0
IL6R	3570	broad.mit.edu	37	1	154403047	154403047	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:154403047C>T	ENST00000368485.3	+	3	860	c.423C>T	c.(421-423)tcC>tcT	p.S141S	IL6R_ENST00000344086.4_Silent_p.S141S	NM_000565.3	NP_000556.1	P08887	IL6RA_HUMAN	interleukin 6 receptor	141					acute-phase response|ciliary neurotrophic factor-mediated signaling pathway|defense response to Gram-negative bacterium|defense response to Gram-positive bacterium|endocrine pancreas development|hepatic immune response|negative regulation of collagen biosynthetic process|negative regulation of interleukin-8 production|positive regulation of activation of Janus kinase activity|positive regulation of anti-apoptosis|positive regulation of chemokine production|positive regulation of interleukin-6 production|positive regulation of leukocyte chemotaxis|positive regulation of MAPKKK cascade|positive regulation of osteoblast differentiation|positive regulation of smooth muscle cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein|regulation of apoptosis	apical plasma membrane|basolateral plasma membrane|extracellular space|interleukin-6 receptor complex	ciliary neurotrophic factor binding|enzyme binding|protein homodimerization activity		IL6R/ATP8B2(2)	breast(2)|large_intestine(1)|ovary(3)	6	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GCACCCCATCCCTGACGACAA	0.592000													30	17					0	0	0.002096	0	0
GRIN2A	2903	broad.mit.edu	37	16	9858655	9858655	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:9858655C>T	ENST00000396573.2	-	14	3055	c.2746G>A	c.(2746-2748)Gac>Aac	p.D916N	GRIN2A_ENST00000396575.2_Missense_Mutation_p.D916N|GRIN2A_ENST00000404927.2_Missense_Mutation_p.D916N|GRIN2A_ENST00000562109.1_Missense_Mutation_p.D916N|GRIN2A_ENST00000535259.1_Missense_Mutation_p.D759N|GRIN2A_ENST00000330684.3_Missense_Mutation_p.D916N	NM_000833.3	NP_000824.1	Q12879	NMDE1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 2A	916					response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			NS(7)|breast(5)|cervix(1)|endometrium(11)|kidney(6)|large_intestine(36)|lung(71)|ovary(4)|prostate(9)|skin(45)|upper_aerodigestive_tract(2)|urinary_tract(1)	198					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TTGGGTGAGTCCATTCTTGAG	0.458000													58	85					0	0	0.003610	0	0
RPE65	6121	broad.mit.edu	37	1	68912499	68912499	+	Missense_Mutation	SNP	G	G	A	rs61752865		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:68912499G>A	ENST00000262340.5	-	3	192	c.139C>T	c.(139-141)Cca>Tca	p.P47S		NM_000329.2	NP_000320.1	Q16518	RPE65_HUMAN	retinal pigment epithelium-specific protein 65kDa	47					visual perception	cytoplasm|plasma membrane	all-trans-retinyl-palmitate hydrolase activity|metal ion binding|retinol isomerase activity			central_nervous_system(1)|kidney(3)|large_intestine(12)|lung(15)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	35						AAGAGTCCTGGCCCACATCGA	0.517000													28	35					0	0	0.002096	0	0
CABP2	51475	broad.mit.edu	37	11	67287268	67287268	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:67287268G>A	ENST00000294288.4	-	6	702	c.633C>T	c.(631-633)ttC>ttT	p.F211F	CABP2_ENST00000353903.5_Silent_p.F154F	NM_016366.2	NP_057450.2	Q9NPB3	CABP2_HUMAN	calcium binding protein 2	211	EF-hand 4.				signal transduction	Golgi apparatus|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			endometrium(2)|large_intestine(1)|lung(3)|prostate(1)|skin(2)	9						GGGTACCTTCGAAGTCGACCA	0.642000													45	70					0	0	0.003610	0	0
SERPINB11	89778	broad.mit.edu	37	18	61390710	61390710	+	RNA	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:61390710G>A	ENST00000544088.1	+	0	1318				SERPINB11_ENST00000538847.1_RNA|SERPINB11_ENST00000536691.1_RNA|SERPINB11_ENST00000382749.5_RNA	NM_080475.2	NP_536723.2	Q96P15	SPB11_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)						regulation of proteolysis	cytoplasm	serine-type endopeptidase inhibitor activity			breast(1)|cervix(1)|kidney(1)|lung(3)	6		Esophageal squamous(42;0.129)				CGGCCAAAAAGCTGTTCACAC	0.483000													8	13					0	0	0.003080	0	0
FASTKD5	60493	broad.mit.edu	37	20	3127866	3127866	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:3127866C>T	ENST00000380266.3	-	2	2172	c.1851G>A	c.(1849-1851)agG>agA	p.R617R	UBOX5_ENST00000348031.2_Intron|UBOX5-AS1_ENST00000446537.1_RNA|UBOX5_ENST00000217173.2_Intron	NM_021826.4	NP_068598.1	Q7L8L6	FAKD5_HUMAN	FAST kinase domains 5	617					apoptosis|cellular respiration	mitochondrion	ATP binding|protein kinase activity			breast(2)|endometrium(2)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|urinary_tract(2)	19						CATGCTCAAGCCTTAATTTGG	0.438000													32	120					0	0	0.002096	0	0
SPAM1	6677	broad.mit.edu	37	7	123594331	123594331	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:123594331G>A	ENST00000340011.5	+	3	1064	c.707G>A	c.(706-708)gGa>gAa	p.G236E	SPAM1_ENST00000460182.1_Missense_Mutation_p.G236E|SPAM1_ENST00000402183.2_Missense_Mutation_p.G236E|SPAM1_ENST00000439500.1_Missense_Mutation_p.G236E|SPAM1_ENST00000223028.7_Missense_Mutation_p.G236E	NM_003117.4	NP_003108.2	P38567	HYALP_HUMAN	sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding)	236					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			breast(1)|cervix(1)|endometrium(3)|kidney(5)|large_intestine(5)|lung(23)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	46					Hyaluronidase(DB00070)	GGTTACAATGGAAGTTGCTTC	0.368000													24	35					0	0	0.002780	0	0
VCAN	1462	broad.mit.edu	37	5	82834173	82834173	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:82834173G>A	ENST00000265077.3	+	8	5916	c.5351G>A	c.(5350-5352)aGg>aAg	p.R1784K	VCAN_ENST00000343200.5_Missense_Mutation_p.R797K|VCAN_ENST00000342785.4_Intron|VCAN_ENST00000512590.2_Intron|VCAN-AS1_ENST00000512090.1_RNA|VCAN_ENST00000513016.1_3'UTR|VCAN_ENST00000502527.2_Intron	NM_004385.4	NP_004376.2	P13611	CSPG2_HUMAN	versican	1784	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			NS(2)|biliary_tract(1)|breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(52)|lung(64)|ovary(8)|pancreas(3)|prostate(13)|skin(14)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	190		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAGTCTGAAAGGGAAATGACA	0.398000													18	91					0	0	0.001216	0	0
CHST12	55501	broad.mit.edu	37	7	2473276	2473276	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2473276C>T	ENST00000258711.6	+	2	1137	c.1002C>T	c.(1000-1002)atC>atT	p.I334I		NM_001243794.1|NM_001243795.1|NM_018641.4	NP_001230723.1|NP_001230724.1|NP_061111.1	Q9NRB3	CHSTC_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 12	334					dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		CGTGCCAGATCGACTACGACT	0.657000													10	101					0	0	0.000673	0	0
GSTP1	2950	broad.mit.edu	37	11	67353922	67353922	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:67353922C>T	ENST00000398606.3	+	7	756	c.507C>T	c.(505-507)ggC>ggT	p.G169G	GSTP1_ENST00000398603.1_Silent_p.G133G|GSTP1_ENST00000498765.1_3'UTR	NM_000852.3	NP_000843.1	P09211	GSTP1_HUMAN	glutathione S-transferase pi 1	169	GST C-terminal.		G -> D (in dbSNP:rs41462048).		anti-apoptosis|cellular response to lipopolysaccharide|central nervous system development|common myeloid progenitor cell proliferation|glutathione metabolic process|negative regulation of acute inflammatory response|negative regulation of ERK1 and ERK2 cascade|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 beta production|negative regulation of JUN kinase activity|negative regulation of leukocyte proliferation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of necrotic cell death|negative regulation of nitric-oxide synthase 2 biosynthetic process|negative regulation of stress-activated MAPK cascade|negative regulation of tumor necrosis factor production|nitric oxide storage|positive regulation of superoxide anion generation|response to reactive oxygen species|xenobiotic metabolic process	cytosol|protein complex	dinitrosyl-iron complex binding|glutathione transferase activity|JUN kinase binding|kinase regulator activity|nitric oxide binding|S-nitrosoglutathione binding			central_nervous_system(1)|cervix(1)|endometrium(4)|lung(2)|ovary(1)	9					Ethacrynic acid(DB00903)|Glutathione(DB00143)	TAGCCCCTGGCTGCCTGGATG	0.647000													19	62					0	0	0.002299	0	0
JSRP1	126306	broad.mit.edu	37	19	2252382	2252382	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:2252382C>T	ENST00000300961.5	-	7	1006	c.942G>A	c.(940-942)gaG>gaA	p.E314E	JSRP1_ENST00000586471.1_Silent_p.E314E	NM_144616.3	NP_653217.1	Q96MG2	JSPR1_HUMAN	junctional sarcoplasmic reticulum protein 1	314	Arg-rich.					sarcoplasmic reticulum membrane				haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)|pancreas(1)|urinary_tract(1)	6				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCCGCTGCTCCTCGTCGGGAC	0.761000													5	3					0	0	0.000602	0	0
PPIAL4G	644591	broad.mit.edu	37	1	143767584	143767584	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:143767584T>G	ENST00000419275.1	-	1	297	c.265A>C	c.(265-267)Atc>Ctc	p.I89L		NM_001123068.1	NP_001116540.1	A2BFH1	PAL4G_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like 4G	89	PPIase cyclophilin-type.				protein folding	cytoplasm	peptidyl-prolyl cis-trans isomerase activity			breast(1)|endometrium(2)|kidney(1)|lung(8)|ovary(1)|skin(1)	14						TGCTTTCGGATGAGGTTCTCA	0.468000													22	85					0	0	0.002780	0	0
C7	730	broad.mit.edu	37	5	40955588	40955588	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:40955588G>A	ENST00000313164.9	+	10	1552	c.1193G>A	c.(1192-1194)gGa>gAa	p.G398E		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	398	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				AATCCTGCTGGAAACAAAAGG	0.458000													97	49					0	0	0.003610	0	0
E4F1	1877	broad.mit.edu	37	16	2284186	2284186	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:2284186G>C	ENST00000301727.4	+	10	1438	c.1390G>C	c.(1390-1392)Gcc>Ccc	p.A464P	E4F1_ENST00000564139.1_Missense_Mutation_p.A464P|E4F1_ENST00000565090.1_Intron	NM_004424.3	NP_004415.2	Q66K89	E4F1_HUMAN	E4F transcription factor 1	464	Interaction with BMI1.|Mediates interaction with CDKN2A.				cell division|cell proliferation|interspecies interaction between organisms|mitosis|regulation of growth	cytoplasm|nucleoplasm	DNA binding|ligase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			ovary(1)	1						GAGGCCGTTCGCCTGCGCGCA	0.706000													10	18					0	0	0.000673	0	0
KLC4	89953	broad.mit.edu	37	6	43041663	43041663	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43041663C>T	ENST00000394056.2	+	16	2264	c.1769C>T	c.(1768-1770)tCc>tTc	p.S590F	KLC4_ENST00000479388.1_Missense_Mutation_p.S590F|KLC4_ENST00000453940.2_Missense_Mutation_p.S513F|KLC4_ENST00000347162.5_Missense_Mutation_p.S590F|KLC4_ENST00000394058.1_Missense_Mutation_p.S590F|KLC4_ENST00000259708.3_Missense_Mutation_p.S608F			Q9NSK0	KLC4_HUMAN	kinesin light chain 4	590						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			endometrium(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(4)	23			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			CGAGCAGCCTCCTTGAACTAT	0.527000													22	120					0	0	0.004656	0	0
FSCB	84075	broad.mit.edu	37	14	44974376	44974376	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:44974376C>T	ENST00000340446.4	-	1	2106	c.1815G>A	c.(1813-1815)gaG>gaA	p.E605E		NM_032135.3	NP_115511.3	Q5H9T9	FSCB_HUMAN	fibrous sheath CABYR binding protein	605	Ala-rich.					cilium				breast(4)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(10)|lung(47)|ovary(2)|pancreas(1)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	89				GBM - Glioblastoma multiforme(112;0.128)		CAGCAGGAGCCTCTTCTGCAG	0.597000													12	13					0	0	0.001368	0	0
CXorf21	80231	broad.mit.edu	37	X	30578040	30578040	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:30578040G>A	ENST00000378962.3	-	3	755	c.433C>T	c.(433-435)Ccc>Tcc	p.P145S		NM_025159.2	NP_079435.1	Q9HAI6	CX021_HUMAN	chromosome X open reading frame 21	145										kidney(1)|large_intestine(3)|lung(13)|ovary(1)|stomach(1)|urinary_tract(1)	20						CTCTCAGAGGGAAAATCTGTT	0.433000													22	4					0	0	0.002299	0	0
ACOX1	51	broad.mit.edu	37	17	73945587	73945587	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:73945587G>A	ENST00000537812.1	-	11	2107	c.1459C>T	c.(1459-1461)Cga>Tga	p.R487*	ACOX1_ENST00000293217.5_Nonsense_Mutation_p.R525*|ACOX1_ENST00000301608.4_Nonsense_Mutation_p.R525*	NM_001185039.1	NP_001171968.1	Q15067	ACOX1_HUMAN	acyl-CoA oxidase 1, palmitoyl	525					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|prostaglandin metabolic process|very long-chain fatty acid metabolic process	peroxisomal matrix	acyl-CoA dehydrogenase activity|acyl-CoA oxidase activity|flavin adenine dinucleotide binding|protein N-terminus binding			large_intestine(2)|lung(7)|ovary(2)|prostate(2)|skin(1)	14						TCACTTGCTCGAACAAGGTCA	0.423000													15	72					0	0	0.003163	0	0
LINC00482	284185	broad.mit.edu	37	17	79279528	79279528	+	RNA	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:79279528G>A	ENST00000332012.5	-	0	368					NR_038080.1																						gaaccagggggagctggaaag	0.622000													10	2					0	0	0.000673	0	0
GPRIN1	114787	broad.mit.edu	37	5	176026739	176026739	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:176026739C>A	ENST00000303991.4	-	2	274	c.97G>T	c.(97-99)Ggg>Tgg	p.G33W		NM_052899.2	NP_443131.2	Q7Z2K8	GRIN1_HUMAN	G protein regulated inducer of neurite outgrowth 1	33						growth cone|plasma membrane				NS(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(3)|liver(1)|lung(15)|ovary(2)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_cancers(89;0.00263)|Renal(175;0.000269)|Lung NSC(126;0.00902)|all_lung(126;0.0142)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCAGGCTCCCATCCTGTGGG	0.647000													5	73					0.000602214	0.00101792	0.000602	1	0
TRPA1	8989	broad.mit.edu	37	8	72966005	72966005	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:72966005G>A	ENST00000262209.4	-	13	1834	c.1627C>T	c.(1627-1629)Cgc>Tgc	p.R543C	RP11-383H13.1_ENST00000457356.4_3'UTR	NM_007332.2	NP_015628.2	O75762	TRPA1_HUMAN	transient receptor potential cation channel, subfamily A, member 1	543						integral to plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(26)|lung(44)|ovary(4)|prostate(6)|stomach(1)	98			Epithelial(68;0.223)		Menthol(DB00825)	TCATCCAGGCGATCTGTGCAC	0.478000													7	47					0	0	0.004482	0	0
MROH7	374977	broad.mit.edu	37	1	55136553	55136553	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:55136553C>T	ENST00000414150.2	+	7	1828	c.1550C>T	c.(1549-1551)tCc>tTc	p.S517F	MROH7_ENST00000421030.2_Missense_Mutation_p.S517F|MROH7_ENST00000454855.2_Missense_Mutation_p.S35F|MROH7_ENST00000545244.1_Missense_Mutation_p.S85F|MROH7_ENST00000395690.2_Missense_Mutation_p.S517F|MROH7_ENST00000409996.1_Missense_Mutation_p.S85F|MROH7_ENST00000339553.5_Missense_Mutation_p.S517F					maestro heat-like repeat family member 7																		TCCCTGCCCTCCGTGCAGGCG	0.652000													8	6					0	0	0.000673	0	0
ZC3H4	23211	broad.mit.edu	37	19	47570692	47570692	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:47570692G>A	ENST00000253048.5	-	15	2870	c.2833C>T	c.(2833-2835)Ccc>Tcc	p.P945S	ZC3H4_ENST00000594019.1_Intron	NM_015168.1	NP_055983.1	Q9UPT8	ZC3H4_HUMAN	zinc finger CCCH-type containing 4	945							nucleic acid binding|zinc ion binding			NS(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(13)|ovary(4)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)	41		all_cancers(25;3.3e-08)|all_epithelial(76;2.28e-06)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|all_neural(266;0.026)|Ovarian(192;0.0392)|Breast(70;0.0889)		OV - Ovarian serous cystadenocarcinoma(262;5.76e-05)|all cancers(93;7.69e-05)|Epithelial(262;0.00354)|GBM - Glioblastoma multiforme(486;0.0372)		GGGTGCCCGGGGAGTGGGTCC	0.682000													43	66					0	0	0.003610	0	0
TNXB	7148	broad.mit.edu	37	6	32023726	32023726	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32023726G>A	ENST00000375244.3	-	24	8570	c.8369C>T	c.(8368-8370)aCc>aTc	p.T2790I	TNXB_ENST00000375247.2_Missense_Mutation_p.T2790I			P22105	TENX_HUMAN	tenascin XB	2848					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GCCCCCCACGGTGACCTCGCT	0.682000													156	719					0	0	0.003610	0	0
GOLPH3L	55204	broad.mit.edu	37	1	150621114	150621114	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:150621114G>A	ENST00000271732.3	-	5	585	c.541C>T	c.(541-543)Ctg>Ttg	p.L181L	GOLPH3L_ENST00000540514.1_Silent_p.L137L	NM_018178.5	NP_060648.2	Q9H4A5	GLP3L_HUMAN	golgi phosphoprotein 3-like	181						Golgi cisterna membrane				breast(1)|endometrium(1)|large_intestine(2)|lung(3)|ovary(1)	8	all_cancers(9;3.09e-52)|all_epithelial(9;4.47e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000615)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;1.2e-23)|all cancers(9;4.81e-23)|OV - Ovarian serous cystadenocarcinoma(6;1.93e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			TCAAATAGCAGGAAATTCTGC	0.418000													50	17					0	0	0.003610	0	0
TNXB	7148	broad.mit.edu	37	6	32047071	32047071	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32047071C>T	ENST00000375244.3	-	11	4315	c.4114G>A	c.(4114-4116)Gag>Aag	p.E1372K	TNXB_ENST00000375247.2_Missense_Mutation_p.E1372K			P22105	TENX_HUMAN	tenascin XB	1459	Fibronectin type-III 6.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						AGGAGCGGCTCCTCGGGGGAC	0.637000													59	602					0	0	0.003610	0	0
SCGB3A2	117156	broad.mit.edu	37	5	147258400	147258400	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:147258400A>G	ENST00000296694.4	+	1	127	c.34A>G	c.(34-36)Atc>Gtc	p.I12V	SCGB3A2_ENST00000514688.1_Intron|SCGB3A2_ENST00000504320.1_Intron	NM_054023.4	NP_473364.1	Q96PL1	SG3A2_HUMAN	secretoglobin, family 3A, member 2	12						extracellular region	binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGGTGACCATCAGCCTTTG	0.373000													79	103					0	0	0.003610	0	0
ANKRD17	26057	broad.mit.edu	37	4	73956602	73956602	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:73956602G>A	ENST00000358602.4	-	29	6859	c.6743C>T	c.(6742-6744)cCc>cTc	p.P2248L	ANKRD17_ENST00000330838.6_Missense_Mutation_p.P1997L|ANKRD17_ENST00000509867.2_Missense_Mutation_p.P2135L	NM_032217.3	NP_115593.3	O75179	ANR17_HUMAN	ankyrin repeat domain 17	2248					interspecies interaction between organisms	cytoplasm|nucleus	RNA binding			NS(3)|breast(2)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(39)|ovary(6)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)	96	Breast(15;0.000295)		Epithelial(6;8.86e-07)|OV - Ovarian serous cystadenocarcinoma(6;6.22e-06)|all cancers(17;1.51e-05)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			AAATGGTAAGGGGGCACTGAA	0.463000													61	91					0	0	0.003610	0	0
SLC17A8	246213	broad.mit.edu	37	12	100751232	100751232	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:100751232G>A	ENST00000323346.5	+	1	376	c.63G>A	c.(61-63)gtG>gtA	p.V21V	SLC17A8_ENST00000392989.3_Silent_p.V21V	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	21					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						AGGAAGGAGTGAAGAACGCCG	0.408000													19	66					0	0	0.001523	0	0
PCDHA5	56143	broad.mit.edu	37	5	140202124	140202124	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140202124C>T	ENST00000529859.1	+	1	764	c.764C>T	c.(763-765)cCa>cTa	p.P255L	PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Missense_Mutation_p.P255L|PCDHA2_ENST00000526136.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA5_ENST00000378126.3_Missense_Mutation_p.P255L	NM_018908.2	NP_061731.1														NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(8)|liver(1)|lung(22)|ovary(2)|prostate(6)|skin(4)|upper_aerodigestive_tract(3)	60			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAAAATGCACCAAGTGGGACA	0.358000													16	87					0	0	0.004007	0	0
MX2	4600	broad.mit.edu	37	21	42767611	42767611	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:42767611G>A	ENST00000330714.3	+	7	1153	c.969G>A	c.(967-969)atG>atA	p.M323I	MX2_ENST00000543692.1_3'UTR|MX2_ENST00000496774.1_3'UTR	NM_002463.1	NP_002454.1	P20592	MX2_HUMAN	myxovirus (influenza virus) resistance 2 (mouse)	323					response to virus|type I interferon-mediated signaling pathway	cytoplasm|nucleus	GTP binding|GTPase activity			breast(2)|endometrium(3)|large_intestine(6)|lung(12)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)	34		Prostate(19;1.57e-07)|all_epithelial(19;0.0222)				AGGGCTACATGATTGTGAAGT	0.488000													17	28					0	0	0.001216	0	0
GLI2	2736	broad.mit.edu	37	2	121708851	121708851	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:121708851C>T	ENST00000452319.1	+	4	347	c.287C>T	c.(286-288)tCt>tTt	p.S96F	GLI2_ENST00000361492.4_Missense_Mutation_p.S96F|GLI2_ENST00000314490.11_5'UTR|GLI2_ENST00000435313.2_3'UTR			P10070	GLI2_HUMAN	GLI family zinc finger 2	96					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CCTGTCATCTCTGACATCTCC	0.642000													37	65					0	0	0.001951	0	0
DNAH12	201625	broad.mit.edu	37	3	57494215	57494215	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:57494215G>A	ENST00000351747.2	-	7	775	c.595C>T	c.(595-597)Caa>Taa	p.Q199*	DNAH12_ENST00000311202.6_Nonsense_Mutation_p.Q199*|DNAH12_ENST00000389536.4_Nonsense_Mutation_p.Q199*	NM_178504.4	NP_848599.3	Q6ZR08	DYH12_HUMAN	dynein, axonemal, heavy chain 12	199	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(3)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|prostate(1)|skin(1)	25						GAGAATATTTGATTTCTTGCC	0.353000													19	32					0	0	0.007413	0	0
XPR1	9213	broad.mit.edu	37	1	180853152	180853152	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:180853152C>T	ENST00000367590.4	+	15	2239	c.2041C>T	c.(2041-2043)Cgt>Tgt	p.R681C	XPR1_ENST00000367589.3_Missense_Mutation_p.R616C	NM_004736.3	NP_004727.2	Q9UBH6	XPR1_HUMAN	xenotropic and polytropic retrovirus receptor 1	681						integral to plasma membrane	G-protein coupled receptor activity	p.R681C(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	35						ATCCAAGGCTCGTGACACTAA	0.378000													22	69					0	0	0.003330	0	0
MGRN1	23295	broad.mit.edu	37	16	4701967	4701967	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:4701967C>T	ENST00000399577.5	+	3	304	c.211C>T	c.(211-213)Ccc>Tcc	p.P71S	MGRN1_ENST00000262370.7_Missense_Mutation_p.P71S|MGRN1_ENST00000415496.1_Missense_Mutation_p.P71S|MGRN1_ENST00000586183.1_Missense_Mutation_p.P71S|MGRN1_ENST00000588994.1_Missense_Mutation_p.P71S	NM_001142290.2	NP_001135762.1	O60291	MGRN1_HUMAN	mahogunin ring finger 1, E3 ubiquitin protein ligase	71					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18						CTCCTAGTTTCCCTACGTCAC	0.612000													13	40					0	0	0.004990	0	0
CPT1C	126129	broad.mit.edu	37	19	50203940	50203940	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:50203940G>A	ENST00000392518.4	+	5	653		c.e5-1		CPT1C_ENST00000323446.5_Splice_Site|CPT1C_ENST00000405931.2_Splice_Site|CPT1C_ENST00000354199.5_Splice_Site|CPT1C_ENST00000598293.1_Splice_Site	NM_001199752.1	NP_001186681.1	Q8TCG5	CPT1C_HUMAN	carnitine palmitoyltransferase 1C						fatty acid metabolic process	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(1)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.00786)		TCTCCCCGCAGGGGTGGACAA	0.662000													37	41					0	0	0.006999	0	0
GPX6	257202	broad.mit.edu	37	6	28472169	28472169	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:28472169C>T	ENST00000361902.1	-	5	615	c.566G>A	c.(565-567)gGg>gAg	p.G189E	GPX6_ENST00000474923.1_Missense_Mutation_p.G156S	NM_182701.1	NP_874360.1	P59796	GPX6_HUMAN	glutathione peroxidase 6 (olfactory)	189					response to oxidative stress	extracellular region	glutathione peroxidase activity			NS(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19					Glutathione(DB00143)	TCCATCGGGCCCCACCAGAAA	0.522000													21	85					0	0	0.001523	0	0
RTP4	64108	broad.mit.edu	37	3	187089093	187089093	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:187089093C>T	ENST00000259030.2	+	2	783	c.673C>T	c.(673-675)Cca>Tca	p.P225S		NM_022147.2	NP_071430.2	Q96DX8	RTP4_HUMAN	receptor (chemosensory) transporter protein 4	225					detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	11	all_cancers(143;4.66e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		AGACCCAGATCCACTGAACAT	0.428000													13	27					0	0	0.001855	0	0
TTC8	123016	broad.mit.edu	37	14	89307837	89307837	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:89307837C>T	ENST00000338104.6	+	5	580	c.528C>T	c.(526-528)tcC>tcT	p.S176S	TTC8_ENST00000536576.1_Intron|TTC8_ENST00000345383.5_Silent_p.S176S|TTC8_ENST00000354441.6_Intron|TTC8_ENST00000346301.4_Intron|TTC8_ENST00000380656.2_Silent_p.S186S			Q8TAM2	TTC8_HUMAN	tetratricopeptide repeat domain 8	186					cilium assembly|establishment of anatomical structure orientation|sensory processing	BBSome|centrosome|cilium membrane|microtubule basal body	protein binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|prostate(1)	15						CAAAGTATTCCCAGAAACCTA	0.308000													21	43					0	0	0.002299	0	0
ANKMY2	57037	broad.mit.edu	37	7	16649313	16649313	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:16649313G>A	ENST00000306999.2	-	7	1067	c.824C>T	c.(823-825)cCt>cTt	p.P275L		NM_020319.2	NP_064715.1	Q8IV38	ANKY2_HUMAN	ankyrin repeat and MYND domain containing 2	275						cilium	zinc ion binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|urinary_tract(1)	23	Lung NSC(10;0.103)|all_lung(11;0.204)			UCEC - Uterine corpus endometrioid carcinoma (126;0.195)		TTCACAGTAAGGAAATTTTCT	0.393000													39	59					0	0	0.006230	0	0
PCED1B	91523	broad.mit.edu	37	12	47630108	47630108	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:47630108G>A	ENST00000546455.1	+	4	1993	c.1262G>A	c.(1261-1263)aGa>aAa	p.R421K	PCED1B_ENST00000432328.1_Missense_Mutation_p.R421K					PC-esterase domain containing 1B																		CCTTCAAAGAGAAGGGCCCCA	0.562000													4	12					0	0	0.000248	0	0
TSPAN8	7103	broad.mit.edu	37	12	71519134	71519134	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:71519134A>C	ENST00000393330.2	-	12	1246	c.694T>G	c.(694-696)Tgc>Ggc	p.C232G	TSPAN8_ENST00000247829.3_Missense_Mutation_p.C232G|TSPAN8_ENST00000552128.1_Missense_Mutation_p.C149G|TSPAN8_ENST00000546561.1_Missense_Mutation_p.C232G			P19075	TSN8_HUMAN	tetraspanin 8	232					protein glycosylation	integral to membrane|lysosome	signal transducer activity			breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(3)|lung(7)|skin(3)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(43;0.24)|OV - Ovarian serous cystadenocarcinoma(12;0.244)			CCGATCTGGCAATACAGGACC	0.353000													98	238					0	0	0.003610	0	0
ZCCHC6	79670	broad.mit.edu	37	9	88918036	88918036	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:88918036G>A	ENST00000277141.6	-	26	4350	c.1926C>T	c.(1924-1926)atC>atT	p.I642I	ZCCHC6_ENST00000375960.2_Silent_p.I1117I|ZCCHC6_ENST00000375957.1_Silent_p.I253I|ZCCHC6_ENST00000375963.3_Silent_p.I1353I|ZCCHC6_ENST00000375961.2_Silent_p.I1315I			Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	1353					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(2)|urinary_tract(1)	46						TGAAGTGTCCGATTTTTCCAC	0.348000													52	71					0	0	0.003610	0	0
GPR97	222487	broad.mit.edu	37	16	57719662	57719662	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:57719662G>A	ENST00000333493.4	+	11	1525	c.1364G>A	c.(1363-1365)tGg>tAg	p.W455*	GPR97_ENST00000450388.3_Nonsense_Mutation_p.W335*|GPR97_ENST00000327655.6_Nonsense_Mutation_p.W245*|RP11-405F3.4_ENST00000563062.1_RNA	NM_170776.4	NP_740746.4	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97	455					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(9)|lung(7)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						CTGGTGGTCTGGAAGATCTTC	0.597000													14	25					0	0	0.001855	0	0
PUF60	22827	broad.mit.edu	37	8	144899816	144899816	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:144899816G>A	ENST00000526683.1	-	9	1509	c.954C>T	c.(952-954)ctC>ctT	p.L318L	PUF60_ENST00000349157.6_Silent_p.L301L|PUF60_ENST00000313352.7_Silent_p.L258L|PUF60_ENST00000453551.2_Silent_p.L275L|PUF60_ENST00000456095.2_Silent_p.L289L|PUF60_ENST00000527197.1_Silent_p.L272L|PUF60_ENST00000524570.1_5'UTR	NM_001271098.1|NM_078480.1	NP_001258027.1|NP_510965.1	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa	318	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding			NS(1)|endometrium(1)|kidney(3)|lung(7)|prostate(2)	14	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CGGCAGGTGGGAGGCCTCCAG	0.662000													41	77					0	0	0.003610	0	0
FGD3	89846	broad.mit.edu	37	9	95738957	95738957	+	Missense_Mutation	SNP	C	C	T	rs71496423		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:95738957C>T	ENST00000375482.3	+	3	915	c.419C>T	c.(418-420)cCc>cTc	p.P140L	FGD3_ENST00000337352.6_Missense_Mutation_p.P140L|FGD3_ENST00000468206.1_3'UTR|FGD3_ENST00000416701.2_Missense_Mutation_p.P140L	NM_001083536.1	NP_001077005.1	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	140					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)|ovary(2)|prostate(1)|urinary_tract(1)	17						GAGAACACCCCCCAGAAGGCT	0.647000													12	12					0	0	0.002450	0	0
FMN2	56776	broad.mit.edu	37	1	240371666	240371666	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:240371666C>T	ENST00000319653.9	+	5	3784	c.3554C>T	c.(3553-3555)cCt>cTt	p.P1185L		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1185	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GTGGGAATACCTCCTCCGCCC	0.682000													10	1					0	0	0.001855	0	0
SGPP2	130367	broad.mit.edu	37	2	223386515	223386515	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:223386515G>A	ENST00000321276.7	+	3	494	c.408G>A	c.(406-408)aaG>aaA	p.K136K		NM_152386.2	NP_689599.2	Q8IWX5	SGPP2_HUMAN	sphingosine-1-phosphate phosphatase 2	136					sphingosine metabolic process	endoplasmic reticulum membrane|integral to membrane	dihydrosphingosine-1-phosphate phosphatase activity|sphingosine-1-phosphate phosphatase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	18		Renal(207;0.0376)		Epithelial(121;2.08e-09)|all cancers(144;9.25e-07)|LUSC - Lung squamous cell carcinoma(224;0.011)|Lung(261;0.0143)		AAGTGGCCAAGGATGTCTTGA	0.468000													26	50					0	0	0.005443	0	0
SYNJ1	8867	broad.mit.edu	37	21	34011388	34011388	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:34011388G>A	ENST00000382499.2	-	31	3861	c.3862C>T	c.(3862-3864)Ccg>Tcg	p.P1288S	SYNJ1_ENST00000382491.3_Missense_Mutation_p.P1202S|SYNJ1_ENST00000357345.3_Missense_Mutation_p.P1233S|SYNJ1_ENST00000322229.7_Missense_Mutation_p.P1249S|SYNJ1_ENST00000433931.2_Missense_Mutation_p.P1288S	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	1249	Pro-rich.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						GAAGACTGCGGAGGAAAAGCA	0.493000													26	83					0	0	0.006320	0	0
PLAA	9373	broad.mit.edu	37	9	26920318	26920318	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:26920318A>C	ENST00000397292.3	-	8	1521	c.1104T>G	c.(1102-1104)agT>agG	p.S368R	PLAA_ENST00000520884.1_Missense_Mutation_p.S368R	NM_001031689.2	NP_001026859.1	Q9Y263	PLAP_HUMAN	phospholipase A2-activating protein	368	PFU.				phospholipid metabolic process|signal transduction		phospholipase A2 activator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(3)|lung(3)|prostate(1)	17		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(218;1.32e-05)|LUSC - Lung squamous cell carcinoma(38;0.00011)		CTTCACTAACACTCCACTGAT	0.383000													18	31					0	0	0.001216	0	0
EPPK1	83481	broad.mit.edu	37	8	144946741	144946741	+	Silent	SNP	G	G	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:144946741G>T	ENST00000525985.1	-	2	752	c.681C>A	c.(679-681)gcC>gcA	p.A227A				P58107	EPIPL_HUMAN	epiplakin 1	227						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GGGGCAGCAAGGCTAGCCCCG	0.667000													5	24					1.23904e-05	2.10337e-05	0.000602	1	0
FAM180A	389558	broad.mit.edu	37	7	135418972	135418972	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:135418972G>A	ENST00000338588.3	-	3	538	c.273C>T	c.(271-273)acC>acT	p.T91T	FAM180A_ENST00000415751.1_Silent_p.T91T	NM_205855.3	NP_995327.1	Q6UWF9	F180A_HUMAN	family with sequence similarity 180, member A	91						extracellular region		p.T91T(1)		endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)	14						TGTTGCAGACGGTGCGGAAGT	0.587000													33	70					0	0	0.003755	0	0
CYBB	1536	broad.mit.edu	37	X	37668882	37668882	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:37668882G>A	ENST00000378588.4	+	12	1591	c.1524G>A	c.(1522-1524)aaG>aaA	p.K508K	TM4SF2_ENST00000465127.1_Intron|CYBB_ENST00000536160.1_Silent_p.K241K|CYBB_ENST00000545017.1_Silent_p.K476K	NM_000397.3	NP_000388.2	P04839	CY24B_HUMAN	cytochrome b-245, beta polypeptide	508					electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(20)|prostate(2)|skin(2)	32						TGAAACAAAAGACTTTGTATG	0.423000													9	0					0	0	0.004482	0	0
MYO18B	84700	broad.mit.edu	37	22	26242163	26242163	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:26242163G>A	ENST00000335473.7	+	19	3715	c.3465G>A	c.(3463-3465)caG>caA	p.Q1155Q	MYO18B_ENST00000407587.2_Silent_p.Q1156Q|MYO18B_ENST00000536101.1_Silent_p.Q1155Q	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1155	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						AGGCCCTGCAGAGGAGCCGCA	0.672000													7	12					0	0	0.001984	0	0
ACKR2	1238	broad.mit.edu	37	3	42906718	42906718	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:42906718C>T	ENST00000422265.1	+	3	899	c.724C>T	c.(724-726)Ccc>Tcc	p.P242S	ACKR2_ENST00000273145.2_Missense_Mutation_p.P242S|ACKR2_ENST00000442925.1_Missense_Mutation_p.P242S|ACKR2_ENST00000471537.1_Intron|CYP8B1_ENST00000437102.1_Intron|KRBOX1_ENST00000426937.1_Intron	NM_001296.4	NP_001287.2			atypical chemokine receptor 2																		GAGGCTGAGGCCCGCAGGCCA	0.537000													43	116					0	0	0.003214	0	0
ZNF48	197407	broad.mit.edu	37	16	30410153	30410153	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:30410153C>T	ENST00000320159.2	+	2	1958	c.1582C>T	c.(1582-1584)Cct>Tct	p.P528S		NM_001214906.1|NM_001214907.1|NM_001214909.1|NM_152652.2	NP_001201835.1|NP_001201836.1|NP_001201838.1|NP_689865.2	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	528	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(11)|ovary(2)|pancreas(1)|skin(1)	21						ACCCATGGCCCCTCGACCCCG	0.657000													22	26					0	0	0.002780	0	0
GABRE	2564	broad.mit.edu	37	X	151130954	151130954	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:151130954G>A	ENST00000393914.3	-	5	727	c.8C>T	c.(7-9)tCa>tTa	p.S3L	GABRE_ENST00000370328.3_Silent_p.I168I|GABRE_ENST00000370325.1_Silent_p.I168I			P78334	GBRE_HUMAN	gamma-aminobutyric acid (GABA) A receptor, epsilon	0					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|skin(1)	27	Acute lymphoblastic leukemia(192;6.56e-05)					TGGGCATGGTGATCTCATGCT	0.483000													31	4					0	0	0.001786	0	0
SLC17A6	57084	broad.mit.edu	37	11	22397614	22397614	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:22397614G>A	ENST00000263160.3	+	10	1698	c.1261G>A	c.(1261-1263)Gga>Aga	p.G421R		NM_020346.2	NP_065079.1	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 6	421					sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity	p.G421*(1)		breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)	50						ACTTGCAGTGGGATTCAGTGG	0.398000													59	87					0	0	0.003610	0	0
CNPPD1	27013	broad.mit.edu	37	2	220038093	220038093	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:220038093G>A	ENST00000409789.1	-	8	1096	c.669C>T	c.(667-669)tcC>tcT	p.S223S	CNPPD1_ENST00000360507.5_Silent_p.S223S			Q9BV87	CNPD1_HUMAN	cyclin Pas1/PHO80 domain containing 1	223					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding			endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(4)	12						GCTGGCAGAGGGAGCCCAGGG	0.622000													19	29					0	0	0.001882	0	0
TLR8	51311	broad.mit.edu	37	X	12939932	12939932	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:12939932G>A	ENST00000218032.6	+	2	2860	c.2773G>A	c.(2773-2775)Gga>Aga	p.G925R	TLR8_ENST00000311912.5_Missense_Mutation_p.G943R	NM_138636.4	NP_619542.1	Q9NR97	TLR8_HUMAN	toll-like receptor 8	925	TIR.				cellular response to mechanical stimulus|defense response to virus|I-kappaB kinase/NF-kappaB cascade|immunoglobulin mediated immune response|inflammatory response|innate immune response|positive regulation of innate immune response|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process	endosome membrane	DNA binding|double-stranded RNA binding|single-stranded RNA binding|transmembrane receptor activity			breast(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(21)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TTGGGATCCGGGATTGGCCAT	0.433000													38	4					0	0	0.003214	0	0
TRANK1	9881	broad.mit.edu	37	3	36874255	36874255	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:36874255G>A	ENST00000429976.2	-	21	6934	c.6687C>T	c.(6685-6687)ttC>ttT	p.F2229F	TRANK1_ENST00000428977.2_Silent_p.F1679F|TRANK1_ENST00000301807.6_Silent_p.F1679F			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	2229					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						AATGCTTAGGGAAAAGGACAT	0.368000													36	72					0	0	0.004289	0	0
C6orf165	154313	broad.mit.edu	37	6	88144610	88144610	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:88144610G>A	ENST00000507897.1	+	11	1416	c.1333G>A	c.(1333-1335)Gaa>Aaa	p.E445K	C6ORF165_ENST00000369562.4_Missense_Mutation_p.E445K			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	445										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AAAATATAAAGAAAAATATTA	0.264000													5	13					0	0	0.000602	0	0
AFF3	3899	broad.mit.edu	37	2	100167982	100167982	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:100167982G>A	ENST00000317233.4	-	24	3870	c.3635C>T	c.(3634-3636)tCc>tTc	p.S1212F	AFF3_ENST00000356421.2_Missense_Mutation_p.S1237F|AFF3_ENST00000409236.1_Missense_Mutation_p.S1212F|AFF3_ENST00000409579.1_Missense_Mutation_p.S1237F	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	1212					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						GCCCTGTTGGGAGTACTGGAC	0.592000													10	17					0	0	0.000673	0	0
DZIP1L	199221	broad.mit.edu	37	3	137783575	137783575	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:137783575C>T	ENST00000327532.2	-	15	2399	c.2037G>A	c.(2035-2037)gaG>gaA	p.E679E		NM_173543.2	NP_775814.2	Q8IYY4	DZI1L_HUMAN	DAZ interacting zinc finger protein 1-like	679						intracellular	zinc ion binding			breast(2)|cervix(2)|endometrium(3)|kidney(2)|large_intestine(6)|lung(15)|ovary(1)|pancreas(2)|prostate(1)|skin(1)	35						CTAGCTGCTTCTCCAGGTTTT	0.517000													129	322					0	0	0.003610	0	0
ABCC8	6833	broad.mit.edu	37	11	17436131	17436131	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:17436131G>A	ENST00000302539.4	-	19	2446	c.2321C>T	c.(2320-2322)tCg>tTg	p.S774L	ABCC8_ENST00000389817.3_Missense_Mutation_p.S773L	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	773	ABC transporter 1.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TGGTTTCTGCGAAGCATAGGC	0.547000													108	141					0	0	0.003610	0	0
GDPD2	54857	broad.mit.edu	37	X	69646512	69646512	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:69646512C>T	ENST00000453994.2	+	7	838	c.477C>T	c.(475-477)ttC>ttT	p.F159F	GDPD2_ENST00000538649.1_Silent_p.F80F|GDPD2_ENST00000374382.3_Silent_p.F159F|GDPD2_ENST00000536730.1_Silent_p.F80F|GDPD2_ENST00000472623.1_Intron	NM_001171192.1	NP_001164663.1	Q9HCC8	GDPD2_HUMAN	glycerophosphodiester phosphodiesterase domain containing 2	159					glycerol metabolic process|lipid metabolic process	cytoplasm|cytoskeleton|integral to membrane|plasma membrane	glycerophosphodiester phosphodiesterase activity|glycerophosphoinositol inositolphosphodiesterase activity|metal ion binding			NS(1)|breast(1)|cervix(1)|endometrium(6)|large_intestine(8)|lung(3)|ovary(2)	22	Renal(35;0.156)					CAGCCCCATTCCTTCATATTG	0.607000													7	0					0	0	0.003080	0	0
ARID1A	8289	broad.mit.edu	37	1	27087520	27087520	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:27087520C>T	ENST00000324856.7	+	5	2465	c.2094C>T	c.(2092-2094)tcC>tcT	p.S698S	ARID1A_ENST00000457599.2_Silent_p.S698S|ARID1A_ENST00000374152.2_Silent_p.S315S	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	698					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CTTCCCCGTCCCCTGTTGGCT	0.607000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								21	41					0	0	0.002299	0	0
KIF21B	23046	broad.mit.edu	37	1	200969679	200969679	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:200969679C>T	ENST00000332129.2	-	11	1840	c.1524G>A	c.(1522-1524)cgG>cgA	p.R508R	KIF21B_ENST00000461742.2_Silent_p.R508R|KIF21B_ENST00000422435.2_Silent_p.R508R|KIF21B_ENST00000360529.5_Silent_p.R508R	NM_001252102.1|NM_001252103.1|NM_017596.3	NP_001239031.1|NP_001239032.1|NP_060066.2	O75037	KI21B_HUMAN	kinesin family member 21B	508					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(4)|large_intestine(8)|liver(1)|lung(27)|ovary(3)|pancreas(1)|prostate(5)|skin(8)|stomach(2)|urinary_tract(2)	83						TAGCCGAGGCCCGTGAGAGGC	0.662000													18	65					0	0	0.001882	0	0
LYST	1130	broad.mit.edu	37	1	235904728	235904728	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:235904728G>A	ENST00000389794.3	-	31	8526	c.8352C>T	c.(8350-8352)tcC>tcT	p.S2784S	LYST_ENST00000389793.2_Silent_p.S2784S			Q99698	LYST_HUMAN	lysosomal trafficking regulator	2784					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(27)|lung(66)|ovary(7)|pancreas(1)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	162	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TTACTTGTAGGGATGGGCTGA	0.373000													23	125					0	0	0.006320	0	0
XIRP2	129446	broad.mit.edu	37	2	168105581	168105581	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:168105581A>T	ENST00000409195.1	+	9	7768	c.7679A>T	c.(7678-7680)aAa>aTa	p.K2560I	XIRP2_ENST00000295237.9_Missense_Mutation_p.K2560I|XIRP2_ENST00000409273.1_Missense_Mutation_p.K2338I|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	2385					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						GAAATTGAAAAACAGAAACAG	0.303000													45	43					0	0	0.002852	0	0
FCER1A	2205	broad.mit.edu	37	1	159273800	159273800	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:159273800G>A	ENST00000368115.1	+	4	258	c.159G>A	c.(157-159)ggG>ggA	p.G53G	FCER1A_ENST00000368114.1_Intron	NM_002001.3	NP_001992.1	P12319	FCERA_HUMAN	Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide	53	Ig-like 1.					integral to plasma membrane				autonomic_ganglia(1)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(19)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	33	all_hematologic(112;0.0429)				Benzylpenicilloyl Polylysine(DB00895)|Omalizumab(DB00043)	CATGTAATGGGAACAATTTCT	0.368000													21	65					0	0	0.002299	0	0
TAF1L	138474	broad.mit.edu	37	9	32631360	32631360	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:32631360G>A	ENST00000242310.4	-	1	4307	c.4218C>T	c.(4216-4218)tcC>tcT	p.S1406S		NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	1406					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		ACTCCAGGATGGATGACAGCG	0.448000													68	103					0	0	0.003610	0	0
MAGEA5	4104	broad.mit.edu	37	X	151284219	151284219	+	RNA	SNP	G	G	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:151284219G>T	ENST00000509345.2	-	0	192																											GGTGATCCTGGTCAGCCTGTC	0.537000													6	0					0.00116845	0.00197332	0.001168	1	0
CDC14B	8555	broad.mit.edu	37	9	99296774	99296774	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:99296774G>A	ENST00000375241.1	-	8	1129	c.678C>T	c.(676-678)gcC>gcT	p.A226A	CDC14B_ENST00000375242.3_Silent_p.A189A|CDC14B_ENST00000463569.1_Silent_p.A226A|CDC14B_ENST00000375236.1_Silent_p.A226A|CDC14B_ENST00000265659.2_Silent_p.A226A|CDC14B_ENST00000375240.3_Silent_p.A226A	NM_003671.3|NM_033331.2	NP_003662.1|NP_201588.1	O60729	CC14B_HUMAN	cell division cycle 14B	226	B.				activation of anaphase-promoting complex activity|DNA repair|G2/M transition DNA damage checkpoint	nucleolus|nucleoplasm	protein binding|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)	15		Acute lymphoblastic leukemia(62;0.0559)				GTCCACAGAAGGCAATAAATC	0.348000													14	24					0	0	0.004990	0	0
IL31	386653	broad.mit.edu	37	12	122658709	122658709	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:122658709T>G	ENST00000377035.1	-	1	37	c.11A>C	c.(10-12)cAc>cCc	p.H4P		NM_001014336.1	NP_001014358.1	Q6EBC2	IL31_HUMAN	interleukin 31	4						extracellular space	cytokine activity			central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	13	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;6.93e-05)|Breast(359;0.0544)		OV - Ovarian serous cystadenocarcinoma(86;3.27e-29)|Epithelial(86;4.86e-27)|BRCA - Breast invasive adenocarcinoma(302;0.223)		GATACCTGAGTGAGAGGCCAT	0.577000													10	32					0	0	0.001855	0	0
CKMT1A	548596	broad.mit.edu	37	15	43990946	43990946	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:43990946C>T	ENST00000413453.2	+	8	1643	c.1119C>T	c.(1117-1119)gaC>gaT	p.D373D	CKMT1A_ENST00000434505.1_Silent_p.D373D|STRC_ENST00000541030.1_Intron			P12532	KCRU_HUMAN	creatine kinase, mitochondrial 1A	373	Phosphagen kinase C-terminal.				creatine metabolic process	mitochondrial inner membrane	ATP binding|creatine kinase activity			lung(4)	4		all_cancers(109;3.26e-15)|all_epithelial(112;1.48e-12)|Lung NSC(122;2.76e-08)|all_lung(180;3.1e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;3.56e-07)	Creatine(DB00148)	CTAATTTGGACCGACTAGGCA	0.507000													42	55					0	0	0.003610	0	0
GRIK3	2899	broad.mit.edu	37	1	37285408	37285408	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:37285408G>A	ENST00000373091.3	-	12	1818	c.1802C>T	c.(1801-1803)tCc>tTc	p.S601F	GRIK3_ENST00000373093.4_Missense_Mutation_p.S601F	NM_000831.3	NP_000822.2	Q13003	GRIK3_HUMAN	glutamate receptor, ionotropic, kainate 3	601					negative regulation of synaptic transmission, glutamatergic|regulation of membrane potential|synaptic transmission	cell junction|dendrite cytoplasm|integral to plasma membrane|perikaryon|postsynaptic membrane|terminal button	adenylate cyclase inhibiting metabotropic glutamate receptor activity|extracellular-glutamate-gated ion channel activity|G-protein-coupled receptor binding|kainate selective glutamate receptor activity			breast(4)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(27)|lung(35)|ovary(5)|prostate(3)|skin(5)|stomach(1)|urinary_tract(1)	89		Myeloproliferative disorder(586;0.0258)|all_neural(195;0.169)			L-Glutamic Acid(DB00142)	CACCACCTCGGAGCCAGGGTT	0.577000													7	12					0	0	0.003080	0	0
PREX1	57580	broad.mit.edu	37	20	47267430	47267430	+	Splice_Site	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:47267430A>C	ENST00000396220.1	-	23	2840		c.e23+1		PREX1_ENST00000371941.3_Splice_Site			Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1						actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(6)|large_intestine(27)|lung(53)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	110			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GCACGCAGGCACCTCCTGGTA	0.567000													15	24					0	0	0.004007	0	0
KCNG1	3755	broad.mit.edu	37	20	49621209	49621209	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:49621209C>T	ENST00000371571.4	-	3	1194	c.909G>A	c.(907-909)ctG>ctA	p.L303L	RP5-955M13.3_ENST00000506387.1_RNA|RP5-955M13.4_ENST00000424566.1_RNA	NM_002237.3	NP_002228.2	Q9UIX4	KCNG1_HUMAN	potassium voltage-gated channel, subfamily G, member 1	303						voltage-gated potassium channel complex	voltage-gated potassium channel activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(11)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	35						CCAGGTCGATCAGCGTCAGCG	0.677000													4	10					0	0	0.000602	0	0
CDK5RAP2	55755	broad.mit.edu	37	9	123165332	123165332	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:123165332G>A	ENST00000349780.4	-	34	5238	c.5059C>T	c.(5059-5061)Ctc>Ttc	p.L1687F	CDK5RAP2_ENST00000480467.1_5'UTR|CDK5RAP2_ENST00000359309.3_Missense_Mutation_p.L1646F|CDK5RAP2_ENST00000360822.3_Missense_Mutation_p.L1655F|CDK5RAP2_ENST00000360190.4_Missense_Mutation_p.L1608F	NM_018249.4	NP_060719.4	Q96SN8	CK5P2_HUMAN	CDK5 regulatory subunit associated protein 2	1687					brain development|centrosome organization|chromosome segregation|G2/M transition of mitotic cell cycle|microtubule bundle formation|negative regulation of centriole replication|positive regulation of transcription, DNA-dependent|regulation of neuron differentiation|regulation of spindle checkpoint	cytosol|Golgi apparatus|microtubule|pericentriolar material|perinuclear region of cytoplasm|spindle pole	calmodulin binding|microtubule binding|neuronal Cdc2-like kinase binding|transcription regulatory region DNA binding			breast(6)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(21)|ovary(2)|prostate(2)|skin(6)|urinary_tract(1)	58						TTCCCAGAGAGTGGAGGAGTC	0.522000													14	28					0	0	0.003163	0	0
KLHL22	84861	broad.mit.edu	37	22	20812259	20812259	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:20812259G>A	ENST00000328879.4	-	5	1297	c.1141C>T	c.(1141-1143)Cag>Tag	p.Q381*	KLHL22_ENST00000440659.2_Nonsense_Mutation_p.Q238*	NM_032775.3	NP_116164.2	Q53GT1	KLH22_HUMAN	kelch-like family member 22	381					cell division	Cul3-RING ubiquitin ligase complex				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(12)|skin(2)|upper_aerodigestive_tract(1)	20	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GACTGGATCTGGAACCAGCGG	0.597000													10	26					0	0	0.000978	0	0
CDHR5	53841	broad.mit.edu	37	11	617422	617422	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:617422C>T	ENST00000358353.3	-	16	2789	c.2467G>A	c.(2467-2469)Gat>Aat	p.D823N	CDHR5_ENST00000349570.7_Missense_Mutation_p.D629N|CDHR5_ENST00000397542.2_Missense_Mutation_p.D823N			Q9HBB8	CDHR5_HUMAN	cadherin-related family member 5	823					calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(7)|ovary(1)|skin(2)	23						TCGCCCTCATCGCCGCTGCCG	0.692000													4	5					0	0	0.000602	0	0
NRIP2	83714	broad.mit.edu	37	12	2936809	2936809	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:2936809C>T	ENST00000337508.4	-	5	775	c.735G>A	c.(733-735)caG>caA	p.Q245Q	ITFG2_ENST00000542548.1_Intron	NM_031474.2	NP_113662.1	Q9BQI9	NRIP2_HUMAN	nuclear receptor interacting protein 2	245					proteolysis|transcription, DNA-dependent	cytoplasm|nucleus	aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(2)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			AAAGCAGAGTCTGCAGGCCCA	0.522000													63	113					0	0	0.003610	0	0
KRT79	338785	broad.mit.edu	37	12	53217696	53217696	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:53217696C>T	ENST00000330553.5	-	6	1155	c.1121G>A	c.(1120-1122)gGg>gAg	p.G374E		NM_175834.2	NP_787028.1	Q5XKE5	K2C79_HUMAN	keratin 79	374	Coil 2.|Rod.					keratin filament	structural molecule activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(11)|ovary(2)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	30						ATCAGCCTCCCCCTGCAGCCT	0.612000													16	22					0	0	0.004990	0	0
SH2D7	646892	broad.mit.edu	37	15	78393523	78393523	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:78393523G>A	ENST00000328828.5	+	5	928	c.928G>A	c.(928-930)Gag>Aag	p.E310K	SH2D7_ENST00000409568.2_Missense_Mutation_p.E174K	NM_001101404.1	NP_001094874.1	A6NKC9	SH2D7_HUMAN	SH2 domain containing 7	310										endometrium(2)|kidney(2)|lung(3)	7						GGGTCCCACAGAGTCTCCCAC	0.612000													5	9					0	0	0.000602	0	0
PGD	5226	broad.mit.edu	37	1	10464303	10464303	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:10464303C>T	ENST00000538557.1	+	5	621	c.377C>T	c.(376-378)cCa>cTa	p.P126L	PGD_ENST00000270776.8_Missense_Mutation_p.P139L|PGD_ENST00000541529.1_Missense_Mutation_p.P117L			P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	139					pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			NS(1)|breast(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)	14	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		CGGTATGGCCCATCGCTCATG	0.552000													14	49					0	0	0.004990	0	0
SDK1	221935	broad.mit.edu	37	7	4273011	4273011	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:4273011G>A	ENST00000404826.2	+	41	6091	c.5952G>A	c.(5950-5952)gcG>gcA	p.A1984A	SDK1_ENST00000389531.3_Silent_p.A1964A|SDK1_ENST00000466611.1_3'UTR	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1984	Fibronectin type-III 13.				cell adhesion	integral to membrane		p.A1984A(1)		NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TGAATGAGGCGGGCTACGGGG	0.617000													17	154					0	0	0.007413	0	0
TCTEX1D1	200132	broad.mit.edu	37	1	67220397	67220397	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:67220397G>A	ENST00000282670.2	+	2	184	c.56G>A	c.(55-57)gGg>gAg	p.G19E	TCTEX1D1_ENST00000491611.1_3'UTR	NM_152665.2	NP_689878.2	Q8N7M0	TC1D1_HUMAN	Tctex1 domain containing 1	19										large_intestine(2)|lung(10)|skin(1)	13						AAGAAAAGAGGGAGTATTTCT	0.353000													14	10					0	0	0.003163	0	0
C6orf15	29113	broad.mit.edu	37	6	31079678	31079678	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31079678C>T	ENST00000259870.3	-	2	461	c.458G>A	c.(457-459)gGg>gAg	p.G153E		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	153										endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						AGAAGACTCCCCAGGCAAAGG	0.647000													17	135					0	0	0.004990	0	0
BAI3	577	broad.mit.edu	37	6	69772857	69772857	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:69772857G>A	ENST00000370598.1	+	16	3186	c.2365G>A	c.(2365-2367)Gtg>Atg	p.V789M		NM_001704.2	NP_001695.1	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	789					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(4)|central_nervous_system(5)|endometrium(5)|kidney(2)|large_intestine(28)|liver(1)|lung(111)|ovary(10)|pancreas(4)|prostate(7)|skin(22)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	210		all_lung(197;0.212)				CAAAATCATCGTGGTCACAAT	0.368000													31	2					0	0	0.002836	0	0
SPOCD1	90853	broad.mit.edu	37	1	32279600	32279600	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:32279600G>A	ENST00000360482.2	-	2	1464	c.1335C>T	c.(1333-1335)tcC>tcT	p.S445S	SPOCD1_ENST00000257100.3_Intron|SPOCD1_ENST00000533231.1_Silent_p.S445S|SPOCD1_ENST00000373648.2_Silent_p.S445S	NM_144569.4	NP_653170.3	Q6ZMY3	SPOC1_HUMAN	SPOC domain containing 1	445					transcription, DNA-dependent					NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|liver(1)|lung(7)|ovary(6)|prostate(1)|skin(3)|stomach(1)|urinary_tract(2)	37		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)|Ovarian(437;0.199)		STAD - Stomach adenocarcinoma(196;0.18)		TGTCCTGGTGGGAGTTGTCTG	0.572000													26	75					0	0	0.006320	0	0
ZNF790	388536	broad.mit.edu	37	19	37310048	37310048	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:37310048C>A	ENST00000356725.4	-	5	1318	c.1198G>T	c.(1198-1200)Ggg>Tgg	p.G400W	CTD-2162K18.5_ENST00000588906.1_RNA|CTD-2162K18.5_ENST00000587278.1_RNA	NM_001242802.1|NM_206894.3	NP_001229731.1|NP_996777.2	Q6PG37	ZN790_HUMAN	zinc finger protein 790	400					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			biliary_tract(1)|endometrium(2)|kidney(2)|large_intestine(14)|lung(7)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	32	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			TAGGCTTTCCCACATTTCTCA	0.403000													29	67					9.39395e-14	1.60231e-13	0.006320	1	0
NADK	65220	broad.mit.edu	37	1	1696731	1696731	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:1696731G>A	ENST00000344463.4	-	2	336	c.115C>T	c.(115-117)Cgg>Tgg	p.R39W	NADK_ENST00000341426.5_Missense_Mutation_p.R39W|NADK_ENST00000492768.1_5'UTR|NADK_ENST00000378625.1_Missense_Mutation_p.R39W|NADK_ENST00000341991.3_Missense_Mutation_p.R39W			O95544	NADK_HUMAN	NAD kinase	39					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding			NS(1)|autonomic_ganglia(1)|endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)|stomach(1)|urinary_tract(1)	17	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		GCCCGGCCCCGGATGGGGTGG	0.577000													27	66					0	0	0.006320	0	0
IL16	3603	broad.mit.edu	37	15	81600992	81600992	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:81600992C>T	ENST00000394660.2	+	19	4209	c.3849C>T	c.(3847-3849)atC>atT	p.I1283I	IL16_ENST00000394652.2_Silent_p.I583I|IL16_ENST00000302987.4_Silent_p.I1284I|RP11-761I4.4_ENST00000607019.1_RNA	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	1284	PDZ 4.				immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity			NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						GAGATGAAATCTTACAGCTGG	0.517000													24	34					0	0	0.005443	0	0
LAS1L	81887	broad.mit.edu	37	X	64743512	64743512	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:64743512G>A	ENST00000374811.3	-	11	1416	c.1376C>T	c.(1375-1377)tCc>tTc	p.S459F	LAS1L_ENST00000312391.8_3'UTR|LAS1L_ENST00000374807.5_Missense_Mutation_p.S442F|LAS1L_ENST00000374804.5_Missense_Mutation_p.S400F	NM_031206.4	NP_112483.1	Q9Y4W2	LAS1L_HUMAN	LAS1-like (S. cerevisiae)	459						MLL1 complex|nucleolus	protein binding			breast(4)|endometrium(3)|kidney(1)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(2)|urinary_tract(1)	33						CCAGTCAAGGGAGGCGGAGCA	0.577000													4	1					0	0	0.000248	0	0
LOC645166	645166	broad.mit.edu	37	1	148932815	148932815	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:148932815C>T	ENST00000539543.1	+	0	71					NR_027355.1																						AGCTAGCCCGCCAGGCCTCCA	0.597000													12	145					0	0	0.000978	0	0
SLC9A7	84679	broad.mit.edu	37	X	46466519	46466519	+	Silent	SNP	G	G	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:46466519G>T	ENST00000328306.4	-	17	2071	c.2046C>A	c.(2044-2046)tcC>tcA	p.S682S	SLC9A7_ENST00000464933.1_5'UTR	NM_001257291.1|NM_032591.2	NP_001244220.1|NP_115980.1	Q96T83	SL9A7_HUMAN	solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7	682					regulation of pH	Golgi membrane|integral to membrane|recycling endosome membrane|trans-Golgi network	potassium:hydrogen antiporter activity|protein homodimerization activity|sodium:hydrogen antiporter activity			breast(2)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(3)|ovary(2)|prostate(1)|skin(1)	21						CCAGACTCGTGGAGGCGGTGT	0.597000													10	1					6.40141e-05	0.000108389	0.000978	1	0
GPR161	23432	broad.mit.edu	37	1	168066078	168066078	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:168066078A>T	ENST00000367838.1	-	5	1080	c.767T>A	c.(766-768)tTt>tAt	p.F256Y	GPR161_ENST00000537209.1_Missense_Mutation_p.F276Y|GPR161_ENST00000539777.1_Missense_Mutation_p.F178Y|GPR161_ENST00000361697.2_Missense_Mutation_p.F256Y|GPR161_ENST00000367835.1_Missense_Mutation_p.F256Y|GPR161_ENST00000367836.1_Missense_Mutation_p.F124Y|GPR161_ENST00000271357.5_Missense_Mutation_p.F256Y|GPR161_ENST00000546300.1_Missense_Mutation_p.F142Y	NM_001267611.1|NM_153832.2	NP_001254540.1|NP_722561.1	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161	256					multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(2)|skin(1)	26	all_hematologic(923;0.215)					CACACCCTGAAAGGCATTCCT	0.597000													48	153					0	0	0.003610	0	0
C8A	731	broad.mit.edu	37	1	57349320	57349320	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:57349320C>T	ENST00000361249.3	+	6	917	c.821C>T	c.(820-822)tCa>tTa	p.S274L		NM_000562.2	NP_000553.1	P07357	CO8A_HUMAN	complement component 8, alpha polypeptide	274	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular space|membrane attack complex				NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	43						CAAGACACTTCATTCTTGAAC	0.403000													9	18					0	0	0.000978	0	0
XPOT	11260	broad.mit.edu	37	12	64815032	64815032	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:64815032C>T	ENST00000332707.5	+	9	1390	c.861C>T	c.(859-861)ttC>ttT	p.F287F		NM_007235.4	NP_009166.2	O43592	XPOT_HUMAN	exportin, tRNA	287	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(7)|lung(12)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45				GBM - Glioblastoma multiforme(28;0.0404)		ATGTTGACTTCCTGGCCAGAT	0.363000													41	98					0	0	0.002852	0	0
SLC22A14	9389	broad.mit.edu	37	3	38347571	38347571	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:38347571G>A	ENST00000273173.4	+	1	145	c.54G>A	c.(52-54)agG>agA	p.R18R	SLC22A14_ENST00000448498.1_Silent_p.R18R	NM_004803.3	NP_004794.2	Q9Y267	S22AE_HUMAN	solute carrier family 22, member 14	18						integral to plasma membrane	organic cation transmembrane transporter activity			central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(5)|prostate(2)|skin(1)	21				KIRC - Kidney renal clear cell carcinoma(284;0.0554)|Kidney(284;0.0696)		ATGCTTCCAGGAACTTGAACC	0.522000													37	99					0	0	0.005524	0	0
TTN	7273	broad.mit.edu	37	2	179448460	179448460	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:179448460C>G	ENST00000589042.1	-	312	65673	c.65449G>C	c.(65449-65451)Gaa>Caa	p.E21817Q	TTN_ENST00000359218.5_Missense_Mutation_p.E12877Q|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.E12944Q|TTN_ENST00000591111.1_Missense_Mutation_p.E20176Q|TTN_ENST00000460472.2_Missense_Mutation_p.E12752Q|TTN_ENST00000342992.6_Missense_Mutation_p.E19249Q|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	20176	Fibronectin type-III 58.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGTACTCTTCCTGGGGAATC	0.458000													10	9					0	0	0.000673	0	0
SERPINB9	5272	broad.mit.edu	37	6	2890624	2890624	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:2890624C>T	ENST00000380698.4	-	7	993	c.904G>A	c.(904-906)Gca>Aca	p.A302T		NM_004155.5	NP_004146.1	P50453	SPB9_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 9	302					anti-apoptosis|cellular response to estrogen stimulus|immune response|mast cell mediated immunity|regulation of proteolysis	cytosol|extracellular space|nucleus	caspase inhibitor activity|protease binding|serine-type endopeptidase inhibitor activity			breast(1)|endometrium(4)|large_intestine(3)|lung(5)|pancreas(1)|prostate(1)	15	Ovarian(93;0.0412)	all_hematologic(90;0.108)				GCTGACATTGCCGACAAGTCA	0.502000													26	157					0	0	0.004656	0	0
DAAM2	23500	broad.mit.edu	37	6	39847148	39847148	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:39847148C>T	ENST00000538976.1	+	14	1922	c.1740C>T	c.(1738-1740)ccC>ccT	p.P580P	DAAM2_ENST00000274867.4_Silent_p.P580P|DAAM2_ENST00000398904.2_Silent_p.P580P	NM_015345.3	NP_056160.2	Q86T65	DAAM2_HUMAN	dishevelled associated activator of morphogenesis 2	580	FH1.|Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(9)|lung(18)|ovary(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)	49	Ovarian(28;0.0355)|Colorectal(47;0.196)					TGGGCCTGCCCCTCCCTCAGG	0.662000													5	66					0	0	0.000602	0	0
SCAMP5	192683	broad.mit.edu	37	15	75310222	75310222	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:75310222C>T	ENST00000361900.6	+	6	512	c.305C>T	c.(304-306)tCc>tTc	p.S102F	SCAMP5_ENST00000568081.1_Missense_Mutation_p.S35F|SCAMP5_ENST00000565923.1_3'UTR|SCAMP5_ENST00000562212.1_Missense_Mutation_p.S102F|SCAMP5_ENST00000545456.1_Missense_Mutation_p.S31F|SCAMP5_ENST00000425597.3_Missense_Mutation_p.S102F	NM_001178111.1	NP_001171582.1	Q8TAC9	SCAM5_HUMAN	secretory carrier membrane protein 5	102					exocytosis|negative regulation of endocytosis|positive regulation of calcium ion-dependent exocytosis|positive regulation of cytokine secretion|protein transport|response to endoplasmic reticulum stress	cell junction|integral to membrane|recycling endosome membrane|synaptic vesicle membrane|trans-Golgi network membrane	protein binding			large_intestine(1)|lung(1)|ovary(1)|urinary_tract(2)	5						ACTGACAGCTCCTTCAGTTTC	0.592000													23	50					0	0	0.003954	0	0
FAM193A	8603	broad.mit.edu	37	4	2648484	2648484	+	Silent	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:2648484C>A	ENST00000324666.5	+	5	714	c.363C>A	c.(361-363)tcC>tcA	p.S121S	FAM193A_ENST00000382839.3_Silent_p.S121S|FAM193A_ENST00000505311.1_Silent_p.S121S|FAM193A_ENST00000502458.1_Silent_p.S121S|FAM193A_ENST00000545951.1_Silent_p.S121S	NM_001256666.1	NP_001243595.1	P78312	F193A_HUMAN	family with sequence similarity 193, member A	121								p.S121S(1)		NS(2)|breast(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(12)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(3)	40						ACCAGCGTTCCGAGGAGGAGC	0.597000													6	217					3.59834e-05	6.10321e-05	0.001168	1	0
PLEKHA4	57664	broad.mit.edu	37	19	49364693	49364693	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:49364693G>A	ENST00000263265.6	-	5	886	c.331C>T	c.(331-333)Ccg>Tcg	p.P111S	PLEKHA4_ENST00000355496.5_Missense_Mutation_p.P111S	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	111	PH.					cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		GGGGCTCCCGGCCCATCTGGT	0.612000													34	50					0	0	0.007835	0	0
TBX6	6911	broad.mit.edu	37	16	30102231	30102231	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:30102231G>A	ENST00000553607.1	-	2	894	c.201C>T	c.(199-201)ccC>ccT	p.P67P	TBX6_ENST00000279386.2_Silent_p.P67P|TBX6_ENST00000395224.2_Silent_p.P67P			O95947	TBX6_HUMAN	T-box 6	67					anatomical structure morphogenesis|mesoderm development|multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(2)|ovary(1)|pancreas(1)	9						GGGGCAGAAGGGGCAGAGGTG	0.667000													11	18					0	0	0.000978	0	0
OR4N5	390437	broad.mit.edu	37	14	20612129	20612129	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:20612129C>T	ENST00000333629.1	+	1	235	c.235C>T	c.(235-237)Ccc>Tcc	p.P79S		NM_001004724.1	NP_001004724.1	Q8IXE1	OR4N5_HUMAN	olfactory receptor, family 4, subfamily N, member 5	79					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|lung(23)|ovary(1)|skin(2)|urinary_tract(1)	29	all_cancers(95;0.00108)		Epithelial(56;7.58e-07)|all cancers(55;3.84e-06)	GBM - Glioblastoma multiforme(265;0.0143)		CATTGTGGTTCCCAGGATGTT	0.478000													69	83					0	0	0.003610	0	0
CHRM5	1133	broad.mit.edu	37	15	34356426	34356426	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:34356426G>A	ENST00000383263.5	+	3	2178	c.1508G>A	c.(1507-1509)aGg>aAg	p.R503K	CHRM5_ENST00000557872.1_Missense_Mutation_p.R503K	NM_012125.3	NP_036257.1	P08912	ACM5_HUMAN	cholinergic receptor, muscarinic 5	503					cell proliferation|inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(10)|ovary(1)|skin(1)	20		all_lung(180;1.76e-08)		all cancers(64;4.82e-17)|GBM - Glioblastoma multiforme(113;2.58e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0262)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)	AGAACCTTCAGGAAGACCTTT	0.483000													27	10					0	0	0.007291	0	0
STON2	85439	broad.mit.edu	37	14	81744729	81744729	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:81744729C>T	ENST00000555447.1	-	6	1338	c.926G>A	c.(925-927)tGg>tAg	p.W309*	STON2_ENST00000267540.2_Nonsense_Mutation_p.W309*	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	309					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		GGTTGCCCTCCAAGGTGAAGC	0.512000													36	49					0	0	0.003755	0	0
AP3B2	8120	broad.mit.edu	37	15	83345327	83345327	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:83345327C>T	ENST00000261722.3	-	14	1758	c.1551G>A	c.(1549-1551)agG>agA	p.R517R	RP11-752G15.3_ENST00000560650.1_RNA|AP3B2_ENST00000535348.1_Silent_p.R485R|AP3B2_ENST00000535359.1_Silent_p.R517R	NM_004644.3	NP_004635.2	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2 subunit	517					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			breast(4)|endometrium(1)|kidney(1)|large_intestine(4)|lung(21)|ovary(4)|pancreas(1)|prostate(3)|urinary_tract(2)	41			BRCA - Breast invasive adenocarcinoma(143;0.229)			CAGGTGCAATCCTGGGGACAT	0.527000													24	14					0	0	0.003954	0	0
LACC1	144811	broad.mit.edu	37	13	44463057	44463057	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:44463057C>T	ENST00000441843.1	+	5	1557	c.1072C>T	c.(1072-1074)Cct>Tct	p.P358S	LACC1_ENST00000325686.6_Missense_Mutation_p.P358S	NM_001128303.1	NP_001121775.1	Q8IV20	CM031_HUMAN	laccase (multicopper oxidoreductase) domain containing 1	358																	TAATCTTCATCCTGCATGTGT	0.403000													25	53					0	0	0.005443	0	0
EVC	2121	broad.mit.edu	37	4	5806507	5806507	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:5806507C>T	ENST00000382674.2	+	17	2684	c.2500C>T	c.(2500-2502)Cct>Tct	p.P834S	EVC_ENST00000264956.6_Missense_Mutation_p.P834S			P57679	EVC_HUMAN	Ellis van Creveld syndrome	834					muscle organ development	integral to membrane				NS(1)|breast(1)|endometrium(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|stomach(1)	28		Myeloproliferative disorder(84;0.117)				ACTCAGCAACCCTTCGTCGGG	0.547000													25	140					0	0	0.007291	0	0
FAM221B	392307	broad.mit.edu	37	9	35825615	35825615	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:35825615C>T	ENST00000423537.2	-	2	813	c.544G>A	c.(544-546)Gga>Aga	p.G182R	TMEM8B_ENST00000377996.1_Intron	NM_001012446.3	NP_001012448.2	A6H8Z2	CI128_HUMAN	family with sequence similarity 221, member B	182										endometrium(2)|kidney(1)|lung(4)	7						GCATCTACTCCCTTTTCAACC	0.502000											OREG0019180	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	40	119					0	0	0.007835	0	0
MKRN3	7681	broad.mit.edu	37	15	23811821	23811821	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:23811821G>A	ENST00000314520.3	+	1	1368	c.892G>A	c.(892-894)Gaa>Aaa	p.E298K	MKRN3_ENST00000564592.1_Intron|MKRN3_ENST00000568252.1_Intron|MKRN3_ENST00000568945.1_3'UTR	NM_005664.3	NP_005655.1	Q13064	MKRN3_HUMAN	makorin ring finger protein 3	298						ribonucleoprotein complex	ligase activity|nucleic acid binding|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(33)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	61		all_cancers(20;8.44e-25)|all_epithelial(15;3.69e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000353)|Colorectal(260;0.14)		all cancers(64;3.02e-06)|Epithelial(43;1.94e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0012)		GAAAGATATGGAACTCTCGTT	0.537000													4	21					0	0	0.000248	0	0
TULP1	7287	broad.mit.edu	37	6	35480454	35480454	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:35480454C>T	ENST00000229771.6	-	2	140	c.61G>A	c.(61-63)Gaa>Aaa	p.E21K	TULP1_ENST00000322263.4_Missense_Mutation_p.E21K	NM_003322.3	NP_003313.3	O00294	TULP1_HUMAN	tubby like protein 1	21					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	19						CTCAGGCTTTCTTCTTCATGC	0.627000													18	110					0	0	0.001216	0	0
ACTRT2	140625	broad.mit.edu	37	1	2939042	2939042	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:2939042C>T	ENST00000378404.2	+	1	997	c.792C>T	c.(790-792)ttC>ttT	p.F264F		NM_080431.4	NP_536356.3	Q8TDY3	ACTT2_HUMAN	actin-related protein T2	264						cytoplasm|cytoskeleton				breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(15)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	26	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		AGGCCCTGTTCGTGCCCCAGC	0.642000													19	68					0	0	0.001523	0	0
IGF1	3479	broad.mit.edu	37	12	102813337	102813337	+	Missense_Mutation	SNP	C	C	T	rs151098426	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:102813337C>T	ENST00000456098.1	-	3	570	c.352G>A	c.(352-354)Gct>Act	p.A118T	IGF1_ENST00000424202.2_Missense_Mutation_p.A102T|IGF1_ENST00000307046.8_Missense_Mutation_p.A118T|IGF1_ENST00000392904.1_Missense_Mutation_p.A118T|IGF1_ENST00000337514.6_Missense_Mutation_p.A118T	NM_001111283.1	NP_001104753.1	P05019	IGF1_HUMAN	insulin-like growth factor 1 (somatomedin C)	118	D.				anti-apoptosis|bone mineralization involved in bone maturation|cellular component movement|DNA replication|glycolate metabolic process|muscle hypertrophy|myoblast differentiation|myoblast proliferation|myotube cell development|negative regulation of smooth muscle cell apoptosis|phosphatidylinositol-mediated signaling|platelet activation|platelet degranulation|positive regulation of activated T cell proliferation|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|positive regulation of fibroblast proliferation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of mitosis|positive regulation of osteoblast differentiation|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of Ras protein signal transduction|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tyrosine phosphorylation of Stat5 protein|Ras protein signal transduction|regulation of multicellular organism growth|satellite cell maintenance involved in skeletal muscle regeneration	platelet alpha granule lumen	growth factor activity|hormone activity|insulin receptor binding|insulin-like growth factor receptor binding|integrin binding			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)|pancreas(1)	11						ACAGAGCGAGCTGACTTGGCA	0.607000													11	25					0	0	0.000673	0	0
NHS	4810	broad.mit.edu	37	X	17745857	17745857	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:17745857G>A	ENST00000380060.3	+	6	3906	c.3568G>A	c.(3568-3570)Gga>Aga	p.G1190R	NHS_ENST00000398097.3_Missense_Mutation_p.G1034R	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	1190						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					AGTTGAGATGGGACCAGATAA	0.393000													45	5					0	0	0.003610	0	0
PKD1L1	168507	broad.mit.edu	37	7	47894497	47894497	+	Silent	SNP	G	G	A	rs149586291		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:47894497G>A	ENST00000289672.2	-	30	4892	c.4842C>T	c.(4840-4842)ccC>ccT	p.P1614P		NM_138295.3	NP_612152.1	Q8TDX9	PK1L1_HUMAN	polycystic kidney disease 1 like 1	1614					cell-cell adhesion	integral to membrane			BBS9/PKD1L1(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(27)|lung(44)|ovary(12)|prostate(5)|skin(8)|stomach(4)|upper_aerodigestive_tract(5)	142						GCAACATGACGGGAAATGCCC	0.383000													35	41					0	0	0.006999	0	0
RAP1GAP	5909	broad.mit.edu	37	1	21928215	21928215	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:21928215G>A	ENST00000542643.2	-	22	1994	c.1692C>T	c.(1690-1692)tcC>tcT	p.S564S	RAP1GAP_ENST00000290101.4_Silent_p.S602S|RAP1GAP_ENST00000374761.2_Silent_p.S569S|RAP1GAP_ENST00000374763.2_Silent_p.S623S|RAP1GAP_ENST00000374765.4_Silent_p.S538S	NM_001145657.1	NP_001139129.1	P47736	RPGP1_HUMAN	RAP1 GTPase activating protein	538					regulation of Ras GTPase activity|signal transduction	cytosol|Golgi membrane|membrane fraction	GTPase activator activity|GTPase activity|protein homodimerization activity|Ras GTPase binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(2)|skin(1)	17		Colorectal(325;0.000147)|Renal(390;0.000734)|Lung NSC(340;0.000861)|all_lung(284;0.000901)|Breast(348;0.012)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0427)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0192)|OV - Ovarian serous cystadenocarcinoma(117;2.3e-26)|COAD - Colon adenocarcinoma(152;1.59e-05)|GBM - Glioblastoma multiforme(114;2.7e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000354)|STAD - Stomach adenocarcinoma(196;0.00645)|KIRC - Kidney renal clear cell carcinoma(1967;0.00862)|READ - Rectum adenocarcinoma(331;0.0625)|Lung(427;0.146)		AGCTCTGAGTGGATGAGTTCT	0.672000													18	28					0	0	0.002299	0	0
ATP5J	522	broad.mit.edu	37	21	27102074	27102074	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:27102074G>A	ENST00000400093.3	-	2	723	c.32C>T	c.(31-33)tCt>tTt	p.S11F	ATP5J_ENST00000400087.3_Missense_Mutation_p.S11F|ATP5J_ENST00000400094.1_Missense_Mutation_p.S11F|ATP5J_ENST00000400090.3_Missense_Mutation_p.S11F|ATP5J_ENST00000284971.3_Missense_Mutation_p.S11F|ATP5J_ENST00000400099.1_Missense_Mutation_p.S11F|ATP5J_ENST00000457143.2_Missense_Mutation_p.S19F	NM_001003701.1|NM_001003703.1|NM_001685.4	NP_001003701.1|NP_001003703.1|NP_001676.2	P18859	ATP5J_HUMAN	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6	11					ATP catabolic process|respiratory electron transport chain		hydrogen ion transmembrane transporter activity			cervix(1)|endometrium(1)|lung(1)|pancreas(1)	4						CCGAATGACAGAGGAGAACCT	0.393000													18	18					0	0	0.001882	0	0
FBXO3	26273	broad.mit.edu	37	11	33790420	33790420	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:33790420G>A	ENST00000530401.1	-	3	340	c.320C>T	c.(319-321)cCt>cTt	p.P107L	FBXO3_ENST00000448981.2_Missense_Mutation_p.P112L|FBXO3_ENST00000526785.1_5'UTR|FBXO3_ENST00000265651.3_Missense_Mutation_p.P112L|FBXO3_ENST00000533103.1_5'UTR|FBXO3_ENST00000534136.1_Missense_Mutation_p.P112L			Q9UK99	FBX3_HUMAN	F-box protein 3	112					proteolysis	nucleus	ubiquitin-protein ligase activity			NS(1)|breast(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(2)|pancreas(1)|stomach(1)	13		Lung NSC(402;0.0804)		BRCA - Breast invasive adenocarcinoma(625;0.00315)|Lung(977;0.00488)|LUSC - Lung squamous cell carcinoma(625;0.008)		AACCATCCGAGGACACCTGGG	0.388000													37	145					0	0	0.004878	0	0
IGLV2-8	28817	broad.mit.edu	37	22	23165548	23165548	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:23165548C>T	ENST00000390317.2	+	0	281																											GTCACCATCTCCTGCACTGGA	0.557000													74	277					0	0	0.003610	0	0
MUC16	94025	broad.mit.edu	37	19	9059045	9059045	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9059045G>A	ENST00000397910.4	-	3	28604	c.28401C>T	c.(28399-28401)ttC>ttT	p.F9467F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9469	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGATAGAGGTGAAAAGAGAAG	0.478000													40	51					0	0	0.005524	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38572510	38572510	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:38572510C>T	ENST00000222345.6	+	3	814	c.305C>T	c.(304-306)tCc>tTc	p.S102F		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	102					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CCAAGCCCCTCCCAGGACACA	0.662000													32	79					0	0	0.005524	0	0
AHNAK2	113146	broad.mit.edu	37	14	105420984	105420984	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:105420984C>T	ENST00000333244.5	-	7	923	c.804G>A	c.(802-804)aaG>aaA	p.K268K		NM_138420.2	NP_612429.2	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	268						nucleus				cervix(4)|endometrium(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)|skin(1)|stomach(3)	33		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CCCGCTTGCTCTTTATGGATT	0.582000													9	12					0	0	0.000978	0	0
DSP	1832	broad.mit.edu	37	6	7585916	7585916	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:7585916C>T	ENST00000379802.3	+	24	8762	c.8421C>T	c.(8419-8421)tcC>tcT	p.S2807S	DSP_ENST00000418664.2_Silent_p.S2208S	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2807	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		AAGCCGCCTCCGTGTCGTCCA	0.572000													43	265					0	0	0.003610	0	0
MYO7A	4647	broad.mit.edu	37	11	76885807	76885807	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:76885807C>T	ENST00000409709.3	+	17	2213	c.1941C>T	c.(1939-1941)ttC>ttT	p.F647F	MYO7A_ENST00000458637.2_Silent_p.F647F|MYO7A_ENST00000409619.2_Silent_p.F636F|MYO7A_ENST00000409893.1_Silent_p.F647F	NM_000260.3	NP_000251.3	Q13402	MYO7A_HUMAN	myosin VIIA	647	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(32)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	64						GGCAGCTGTTCGACCGGCACC	0.617000													6	3					0	0	0.003080	0	0
KCNK17	89822	broad.mit.edu	37	6	39267263	39267263	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:39267263C>T	ENST00000373231.4	-	5	1171	c.939G>A	c.(937-939)atG>atA	p.M313I	KCNK17_ENST00000453413.2_3'UTR	NM_031460.3	NP_113648.2	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	313						integral to membrane	potassium channel activity|voltage-gated ion channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(2)	14						GTATGATTCCCATGGGTCCCT	0.552000													8	64					0	0	0.006214	0	0
MORC1	27136	broad.mit.edu	37	3	108724109	108724109	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:108724109T>A	ENST00000232603.5	-	19	1903	c.1821A>T	c.(1819-1821)gaA>gaT	p.E607D	MORC1_ENST00000483760.1_Missense_Mutation_p.E586D	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	607					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						ATGAAAGAGATTCATGCTTCA	0.348000													15	40					0	0	0.003163	0	0
RUNDC1	146923	broad.mit.edu	37	17	41143029	41143029	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:41143029C>T	ENST00000361677.1	+	5	1150	c.1138C>T	c.(1138-1140)Ccc>Tcc	p.P380S		NM_173079.2	NP_775102.2	Q96C34	RUND1_HUMAN	RUN domain containing 1	380										breast(1)|large_intestine(2)|lung(4)|prostate(1)	8		Breast(137;0.00499)		BRCA - Breast invasive adenocarcinoma(366;0.161)		AGACTACTCTCCCTTGCTGAA	0.577000													23	16					0	0	0.001882	0	0
PTPRT	11122	broad.mit.edu	37	20	40770640	40770640	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:40770640G>A	ENST00000373198.3	-	19	2986	c.2751C>T	c.(2749-2751)gcC>gcT	p.A917A	PTPRT_ENST00000356100.2_Silent_p.A904A|PTPRT_ENST00000373201.1_Silent_p.A885A|PTPRT_ENST00000373193.3_Silent_p.A898A|PTPRT_ENST00000373187.1_Silent_p.A895A|PTPRT_ENST00000373184.1_Silent_p.A885A|PTPRT_ENST00000373190.1_Silent_p.A894A	NM_133170.3	NP_573400.3	O14522	PTPRT_HUMAN	protein tyrosine phosphatase, receptor type, T	895	Tyrosine-protein phosphatase 1.				homophilic cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	cell surface|integral to membrane|plasma membrane	alpha-catenin binding|beta-catenin binding|cadherin binding|delta-catenin binding|gamma-catenin binding|protein tyrosine phosphatase activity|receptor activity			NS(2)|breast(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(12)|large_intestine(26)|liver(1)|lung(63)|ovary(8)|pancreas(2)|prostate(5)|skin(35)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	176		Myeloproliferative disorder(115;0.00452)|Lung NSC(126;0.0573)|all_lung(126;0.0783)				CCTCTGGTAAGGCCTAAAAAG	0.502000													43	83					0	0	0.001951	0	0
TLR1	7096	broad.mit.edu	37	4	38799133	38799133	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:38799133G>A	ENST00000308979.2	-	4	1593	c.1320C>T	c.(1318-1320)ttC>ttT	p.F440F	TLR1_ENST00000502213.2_Silent_p.F440F	NM_003263.3	NP_003254.2	Q15399	TLR1_HUMAN	toll-like receptor 1	440					cellular response to triacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|inflammatory response|innate immune response|macrophage activation|positive regulation of interleukin-6 biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	integral to plasma membrane|phagocytic vesicle membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	protein heterodimerization activity|transmembrane receptor activity			cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(4)|stomach(2)	28						GTAAACATCTGAAAATAGTGT	0.328000													23	156					0	0	0.002780	0	0
TTC7B	145567	broad.mit.edu	37	14	91007723	91007723	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:91007723G>A	ENST00000357056.2	-	21	2693	c.2572C>T	c.(2572-2574)Cgc>Tgc	p.R858C	TTC7B_ENST00000554654.1_5'UTR|TTC7B_ENST00000328459.6_Missense_Mutation_p.R841C			Q86TV6	TTC7B_HUMAN	tetratricopeptide repeat domain 7B	841							binding			NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(8)|ovary(2)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	36		Melanoma(154;0.222)				CAGAGCACGCGGGGGATGATG	0.687000													4	5					0	0	0.000248	0	0
SZT2	23334	broad.mit.edu	37	1	43891737	43891737	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:43891737C>T	ENST00000562955.1	+	21	2958	c.2958C>T	c.(2956-2958)gtC>gtT	p.V986V	SZT2_ENST00000372442.1_Silent_p.V144V	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	986						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						ACACCTGCGTCCATGAGATCC	0.557000													10	35					0	0	0.000978	0	0
TRIM27	5987	broad.mit.edu	37	6	28872399	28872399	+	Silent	SNP	G	G	A	rs141777208		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:28872399G>A	ENST00000377199.3	-	8	1346	c.990C>T	c.(988-990)atC>atT	p.I330I	TRIM27_ENST00000377194.3_Silent_p.I330I	NM_006510.4	NP_006501.1	P14373	TRI27_HUMAN	tripartite motif containing 27	330	B30.2/SPRY.				cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			endometrium(1)|large_intestine(2)|lung(6)|ovary(1)	10						TATCAGAGAGGATCAGGCTGG	0.552000			T	RET	papillary thyroid								8	64					0	0	0.004482	0	0
TTC3	7267	broad.mit.edu	37	21	38512909	38512909	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:38512909C>T	ENST00000399017.2	+	20	4455	c.1708C>T	c.(1708-1710)Ccc>Tcc	p.P570S	TTC3_ENST00000479930.1_3'UTR|TTC3_ENST00000540756.1_Missense_Mutation_p.P260S|TTC3_ENST00000355666.1_Missense_Mutation_p.P570S|TTC3_ENST00000354749.2_Missense_Mutation_p.P570S	NM_003316.3	NP_003307.3	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	570					protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			breast(5)|endometrium(7)|kidney(5)|large_intestine(17)|liver(1)|lung(18)|ovary(4)|prostate(2)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(5)	75		Myeloproliferative disorder(46;0.0412)				TGAACACTACCCCAGTGAGGG	0.368000													48	69					0	0	0.003610	0	0
KLHL24	54800	broad.mit.edu	37	3	183381293	183381293	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:183381293G>A	ENST00000454652.1	+	5	1354	c.968G>A	c.(967-969)cGa>cAa	p.R323Q	KLHL24_ENST00000242810.6_Missense_Mutation_p.R323Q|KLHL24_ENST00000476808.1_Missense_Mutation_p.R323Q			Q6TFL4	KLH24_HUMAN	kelch-like family member 24	323						axon|cytoplasm|perikaryon				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			GGATGTGAGCGAGTTGGAGGA	0.353000													21	55					0	0	0.003954	0	0
ARHGEF7	8874	broad.mit.edu	37	13	111857668	111857668	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:111857668G>A	ENST00000375741.2	+	4	598	c.348G>A	c.(346-348)caG>caA	p.Q116Q	ARHGEF7_ENST00000218789.5_5'UTR|ARHGEF7_ENST00000375723.1_5'UTR|ARHGEF7_ENST00000426073.2_5'UTR|ARHGEF7_ENST00000375739.2_Silent_p.Q66Q|ARHGEF7_ENST00000370623.3_Intron|ARHGEF7_ENST00000317133.5_Silent_p.Q95Q|ARHGEF7_ENST00000375736.4_5'UTR|ARHGEF7_ENST00000375737.5_Silent_p.Q13Q|ARHGEF7_ENST00000544132.1_5'UTR	NM_001113511.1|NM_145735.2	NP_001106983.1|NP_663788.1	Q14155	ARHG7_HUMAN	Rho guanine nucleotide exchange factor (GEF) 7	116	CH.				apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	41	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			ATCAGGGGCAGAATTTTAACA	0.388000													23	32					0	0	0.004656	0	0
ENTPD6	955	broad.mit.edu	37	20	25203577	25203577	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:25203577C>T	ENST00000360031.2	+	12	1328	c.1146C>T	c.(1144-1146)tcC>tcT	p.S382S	ENTPD6_ENST00000433259.2_Silent_p.S349S|ENTPD6_ENST00000485936.1_3'UTR|ENTPD6_ENST00000376652.4_Silent_p.S383S|ENTPD6_ENST00000354989.5_Silent_p.S366S	NM_001247.2	NP_001238.2	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6 (putative)	383						Golgi membrane|integral to membrane	nucleoside-diphosphatase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|prostate(1)|skin(1)	27						ATGCTTTCTCCTACTATTACG	0.607000													34	142					0	0	0.002222	0	0
SLC39A5	283375	broad.mit.edu	37	12	56625132	56625132	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:56625132C>T	ENST00000266980.4	+	2	367	c.74C>T	c.(73-75)tCa>tTa	p.S25L	SLC39A5_ENST00000454355.2_Missense_Mutation_p.S25L	NM_001135195.1	NP_001128667.1	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (zinc transporter), member 5	25					zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			NS(1)|cervix(6)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						GTAGGGGGCTCAGTCCCCAAC	0.622000													27	94					0	0	0.004656	0	0
ITGAL	3683	broad.mit.edu	37	16	30516721	30516721	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:30516721G>A	ENST00000356798.6	+	20	2484	c.2304G>A	c.(2302-2304)gaG>gaA	p.E768E	ITGAL_ENST00000358164.5_Silent_p.E684E|ITGAL_ENST00000433423.2_Intron	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	768					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	TCCCTTTTGAGAAGAACTGTG	0.542000													30	53					0	0	0.002445	0	0
OTUD4	54726	broad.mit.edu	37	4	146067531	146067531	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:146067531G>A	ENST00000454497.2	-	14	1252	c.1115C>T	c.(1114-1116)tCt>tTt	p.S372F	OTUD4_ENST00000447906.2_Missense_Mutation_p.S437F|OTUD4_ENST00000455611.2_5'UTR	NM_001102653.1	NP_001096123.1	Q01804	OTUD4_HUMAN	OTU domain containing 4	436							protein binding			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(10)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	33	all_hematologic(180;0.151)					GAAATAGTTAGATTCTCGACT	0.363000													24	31					0	0	0.006320	0	0
RERE	473	broad.mit.edu	37	1	8424199	8424199	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:8424199G>A	ENST00000337907.3	-	16	2291	c.1657C>T	c.(1657-1659)Ccg>Tcg	p.P553S	RERE_ENST00000400907.2_Intron|RERE_ENST00000400908.2_Missense_Mutation_p.P553S|RERE_ENST00000377464.1_Missense_Mutation_p.P285S|RERE_ENST00000476556.1_5'UTR	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	553					multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		AACATAAACGGTGGCGGGTCC	0.607000													24	60					0	0	0.002780	0	0
PTBP2	58155	broad.mit.edu	37	1	97217021	97217021	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:97217021G>T	ENST00000236228.6	+	3	162	c.80G>T	c.(79-81)aGt>aTt	p.S27I	PTBP2_ENST00000370198.1_Missense_Mutation_p.S27I|PTBP2_ENST00000482253.1_Intron|PTBP2_ENST00000394184.3_Missense_Mutation_p.S38I|PTBP2_ENST00000541987.1_5'UTR|PTBP2_ENST00000370197.1_Missense_Mutation_p.S27I|PTBP2_ENST00000426398.2_Missense_Mutation_p.S27I	NM_021190.2	NP_067013.1	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	27							nucleotide binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|skin(1)	26		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		GTTCTCAGTAGTCCGAACTCT	0.348000													65	80					1.17597e-53	2.01719e-53	0.003610	1	0
MUC16	94025	broad.mit.edu	37	19	9077116	9077116	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9077116G>A	ENST00000397910.4	-	3	10533	c.10330C>T	c.(10330-10332)Cct>Tct	p.P3444S		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3445	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GTGACATCAGGAGATGCACCA	0.478000													28	44					0	0	0.004656	0	0
TMEM171	134285	broad.mit.edu	37	5	72419681	72419681	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:72419681C>T	ENST00000454765.2	+	2	954	c.481C>T	c.(481-483)Ctt>Ttt	p.L161F	TMEM171_ENST00000287773.5_Missense_Mutation_p.L161F			Q8WVE6	TM171_HUMAN	transmembrane protein 171	161						integral to membrane				endometrium(5)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|stomach(1)	15		Lung NSC(167;0.0378)|Ovarian(174;0.0908)|Prostate(461;0.165)		OV - Ovarian serous cystadenocarcinoma(47;1.87e-54)|Lung(70;0.115)		GTGTGGGTTCCTTTCTCTGCA	0.557000													71	74					0	0	0.003610	0	0
TTN	7273	broad.mit.edu	37	2	179501143	179501143	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:179501143C>T	ENST00000589042.1	-	225	41535	c.41311G>A	c.(41311-41313)Gct>Act	p.A13771T	TTN_ENST00000359218.5_Missense_Mutation_p.A4831T|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.A4898T|TTN_ENST00000591111.1_Missense_Mutation_p.A12130T|TTN_ENST00000460472.2_Missense_Mutation_p.A4706T|TTN_ENST00000342992.6_Missense_Mutation_p.A11203T|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12130	Ig-like 94.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAAGTTTAGCCGTGGAGGTC	0.353000													13	15					0	0	0.001368	0	0
DNM3	26052	broad.mit.edu	37	1	172356454	172356454	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:172356454C>T	ENST00000358155.4	+	19	2416	c.2240C>T	c.(2239-2241)cCg>cTg	p.P747L	DNM3_ENST00000367731.1_Missense_Mutation_p.P743L|DNM3_ENST00000355305.5_Missense_Mutation_p.P753L	NM_015569.3	NP_056384.2	Q9UQ16	DYN3_HUMAN	dynamin 3	753	GED.				endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			NS(1)|breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(16)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						GTGTCCACTCCGGCACCCCCT	0.592000													13	33					0	0	0.001855	0	0
GPR152	390212	broad.mit.edu	37	11	67219903	67219903	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:67219903G>A	ENST00000312457.2	-	1	297	c.293C>T	c.(292-294)cCg>cTg	p.P98L	CABP4_ENST00000438189.2_5'UTR|CABP4_ENST00000542025.2_3'UTR	NM_206997.1	NP_996880.1	Q8TDT2	GP152_HUMAN	G protein-coupled receptor 152	98						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	16			BRCA - Breast invasive adenocarcinoma(15;8.18e-06)			TGTCCCCAGCGGCCAGTGTCC	0.657000													10	50					0	0	0.001855	0	0
CCDC180	100499483	broad.mit.edu	37	9	100132243	100132243	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:100132243C>T	ENST00000375202.2	+	46	5713	c.4361C>T	c.(4360-4362)cCc>cTc	p.P1454L	CCDC180_ENST00000529487.1_Missense_Mutation_p.P1454L|CCDC180_ENST00000395220.1_3'UTR|CCDC180_ENST00000357054.1_Missense_Mutation_p.P1399L|RP11-23J9.4_ENST00000534123.1_RNA					coiled-coil domain containing 180																		GAGCTGCTGCCCCAAGTGTGT	0.502000													9	20					0	0	0.000673	0	0
CAND2	23066	broad.mit.edu	37	3	12858846	12858846	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:12858846C>T	ENST00000456430.2	+	10	2456	c.2415C>T	c.(2413-2415)gcC>gcT	p.A805A	CAND2_ENST00000295989.5_Silent_p.A712A	NM_001162499.1	NP_001155971.1	O75155	CAND2_HUMAN	cullin-associated and neddylation-dissociated 2 (putative)	805					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(8)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	37						ACTCATTGGCCCGGTGTGTGG	0.637000													12	54					0	0	0.007413	0	0
CDHR4	389118	broad.mit.edu	37	3	49836508	49836508	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:49836508G>A	ENST00000412678.2	-	3	330	c.322C>T	c.(322-324)Cat>Tat	p.H108Y	CDHR4_ENST00000487256.1_Missense_Mutation_p.H108Y|CDHR4_ENST00000343366.4_Missense_Mutation_p.H108Y	NM_001007540.2	NP_001007541.2	A6H8M9	CDHR4_HUMAN	cadherin-related family member 4	108					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(3)	11						TCCATCACATGGTTGCCACAT	0.577000													3	5					0	0	0.004672	0	0
MYO18B	84700	broad.mit.edu	37	22	26423583	26423583	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:26423583C>A	ENST00000335473.7	+	43	7893	c.7643C>A	c.(7642-7644)cCa>cAa	p.P2548Q	MYO18B_ENST00000407587.2_Missense_Mutation_p.P2549Q|MYO18B_ENST00000536101.1_Missense_Mutation_p.P2548Q	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	2548						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						CGGAGAGAGCCAGGGACGGGG	0.542000													10	2					0.000442599	0.000748444	0.006214	1	0
MATN2	4147	broad.mit.edu	37	8	99019816	99019816	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:99019816G>A	ENST00000254898.5	+	10	1791	c.1560G>A	c.(1558-1560)ggG>ggA	p.G520G	MATN2_ENST00000524308.1_Silent_p.G479G|MATN2_ENST00000522025.2_Silent_p.G236G|MATN2_ENST00000520016.1_Silent_p.G520G|MATN2_ENST00000521689.1_Silent_p.G520G	NM_002380.3|NM_030583.2	NP_002371.3|NP_085072.2	O00339	MATN2_HUMAN	matrilin 2	520	EGF-like 7.					proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(2)|urinary_tract(1)	31	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			GCAGCGATGGGAAGACGTGTG	0.567000													27	149					0	0	0.005443	0	0
KRTAP19-8	728299	broad.mit.edu	37	21	32410611	32410611	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:32410611G>A	ENST00000382822.2	-	1	184	c.152C>T	c.(151-153)cCa>cTa	p.P51L		NM_001099219.1	NP_001092689.1	Q3LI54	KR198_HUMAN	keratin associated protein 19-8	51						intermediate filament				endometrium(2)|upper_aerodigestive_tract(1)	3						GTAGTATAATGGTCGGCAACA	0.493000													39	103					0	0	0.007835	0	0
TCTN1	79600	broad.mit.edu	37	12	111085590	111085590	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:111085590A>G	ENST00000551590.1	+	14	1813	c.1657A>G	c.(1657-1659)Act>Gct	p.T553A	TCTN1_ENST00000377654.3_3'UTR|HVCN1_ENST00000548312.1_Intron|TCTN1_ENST00000397659.4_Missense_Mutation_p.T558A|TCTN1_ENST00000397655.3_Missense_Mutation_p.T539A			Q2MV58	TECT1_HUMAN	tectonic family member 1	553					multicellular organismal development	extracellular region				NS(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(9)|urinary_tract(1)	15						TCTTATTTCCACTGCGGTTAC	0.498000													20	46					0	0	0.001216	0	0
ADAR	103	broad.mit.edu	37	1	154574527	154574527	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:154574527G>A	ENST00000368474.4	-	2	790	c.591C>T	c.(589-591)atC>atT	p.I197I	ADAR_ENST00000368471.3_5'UTR|ADAR_ENST00000292205.5_Silent_p.I240I	NM_001111.4|NM_015840.3|NM_015841.3	NP_001102.2|NP_056655.2|NP_056656.2	P55265	DSRAD_HUMAN	adenosine deaminase, RNA-specific	197					adenosine to inosine editing|gene silencing by RNA|mRNA modification|mRNA processing|type I interferon-mediated signaling pathway	cytoplasm|nucleolus|nucleoplasm	DNA binding|double-stranded RNA adenosine deaminase activity|metal ion binding	p.I197I(1)		NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(4)|prostate(2)|skin(2)	51	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.0997)		LUSC - Lung squamous cell carcinoma(543;0.185)	Colorectal(1306;0.115)		TGGAGACCGCGATTTTCCACA	0.522000													60	144					0	0	0.003610	0	0
OR2A4	79541	broad.mit.edu	37	6	132022493	132022493	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:132022493G>A	ENST00000315453.2	-	1	142	c.49C>T	c.(49-51)Ccc>Tcc	p.P17S	ENPP3_ENST00000357639.3_Intron|ENPP3_ENST00000414305.1_Intron|ENPP3_ENST00000358229.5_Intron	NM_030908.1	NP_112170.1	O95047	OR2A4_HUMAN	olfactory receptor, family 2, subfamily A, member 4	17					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.018)|OV - Ovarian serous cystadenocarcinoma(155;0.041)		GGGCCAACGGGAAATCCCAGT	0.488000													19	28					0	0	0.003330	0	0
SCAF8	22828	broad.mit.edu	37	6	155114102	155114102	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:155114102A>C	ENST00000367178.3	+	5	1043	c.467A>C	c.(466-468)aAt>aCt	p.N156T	SCAF8_ENST00000367186.4_Missense_Mutation_p.N222T|SCAF8_ENST00000417268.1_Missense_Mutation_p.N156T	NM_014892.3	NP_055707.3	Q9UPN6	SCAF8_HUMAN	SR-related CTD-associated factor 8	156					mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(15)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	46						GCTATGAGCAATACTCCAGGT	0.398000													18	23					0	0	0.001523	0	0
ZNF483	158399	broad.mit.edu	37	9	114304657	114304657	+	Missense_Mutation	SNP	C	C	T	rs149958964	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:114304657C>T	ENST00000309235.5	+	6	1600	c.1442C>T	c.(1441-1443)tCg>tTg	p.S481L	ZNF483_ENST00000358151.4_Intron	NM_133464.2	NP_597721.2	Q8TF39	ZN483_HUMAN	zinc finger protein 483	481					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(11)|lung(11)|ovary(1)|skin(5)	31						GATAGTTCATCGCTCACACCA	0.418000													16	18					0	0	0.004007	0	0
MEP1A	4224	broad.mit.edu	37	6	46787396	46787396	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:46787396G>A	ENST00000230588.4	+	7	520	c.511G>A	c.(511-513)Gac>Aac	p.D171N		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	171	Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding	p.D171N(1)		NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			GTCAAGGACGGACCGGGATGA	0.478000													50	311					0	0	0.003610	0	0
BTN3A2	11118	broad.mit.edu	37	6	26373641	26373641	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:26373641C>T	ENST00000356386.2	+	8	1152	c.964_splice	c.e8+1	p.R322_splice	BTN3A2_ENST00000377708.2_Splice_Site_p.R322_splice|BTN3A2_ENST00000527422.1_Splice_Site_p.R322_splice|BTN3A2_ENST00000508906.2_Splice_Site_p.R280_splice|BTN3A2_ENST00000396934.3_Splice_Site_p.R299_splice|BTN3A2_ENST00000396948.1_Splice_Site_p.R322_splice	NM_001197246.2|NM_001197247.1|NM_007047.3	NP_001184175.1|NP_001184176.1|NP_008978.2	P78410	BT3A2_HUMAN	butyrophilin, subfamily 3, member A2	322						integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(5)	10						GTACTTGACTCGTGAGTGGCT	0.433000													18	136					0	0	0.004990	0	0
PLIN3	10226	broad.mit.edu	37	19	4859643	4859643	+	Silent	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:4859643A>G	ENST00000221957.4	-	4	483	c.307T>C	c.(307-309)Ttg>Ctg	p.L103L	PLIN3_ENST00000592528.1_Silent_p.L103L|PLIN3_ENST00000585479.1_Silent_p.L103L	NM_001164189.1|NM_001164194.1|NM_005817.4	NP_001157661.1|NP_001157666.1|NP_005808.3	O60664	PLIN3_HUMAN	perilipin 3	103					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding			cervix(1)|endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)	9					Galsulfase(DB01279)|Idursulfase(DB01271)	TTCTCCTCCAACTTGTCCAGC	0.562000													15	19					0	0	0.004007	0	0
CYFIP2	26999	broad.mit.edu	37	5	156757855	156757855	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:156757855C>T	ENST00000347377.6	+	20	2693	c.2262C>T	c.(2260-2262)gtC>gtT	p.V754V	CYFIP2_ENST00000522463.1_Silent_p.V558V|CYFIP2_ENST00000377576.3_Silent_p.V754V|CYFIP2_ENST00000521420.1_Silent_p.V728V|CYFIP2_ENST00000318218.6_Silent_p.V779V|CYFIP2_ENST00000541131.1_Silent_p.V679V|CYFIP2_ENST00000442283.2_Silent_p.V39V|CYFIP2_ENST00000435847.2_Silent_p.V453V	NM_001037332.2	NP_001032409.2	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	779					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding			breast(1)|endometrium(12)|kidney(2)|lung(23)	38	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGAGACACGTCCAGGTATGGG	0.498000													60	251					0	0	0.003610	0	0
RASD2	23551	broad.mit.edu	37	22	35947656	35947656	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:35947656G>A	ENST00000216127.4	+	3	1020	c.378G>A	c.(376-378)aaG>aaA	p.K126K		NM_014310.3	NP_055125.2	Q96D21	RHES_HUMAN	RASD family, member 2	126					locomotory behavior|positive regulation of protein kinase B signaling cascade|positive regulation of protein sumoylation|regulation of cAMP-mediated signaling	intracellular|plasma membrane	G-protein beta-subunit binding|GTP binding|GTPase activity			endometrium(2)|large_intestine(1)|lung(8)|prostate(1)|skin(1)	13						TGAAGAACAAGACCAAGGAGG	0.607000													18	129					0	0	0.006122	0	0
ETV5	2119	broad.mit.edu	37	3	185783621	185783621	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:185783621C>T	ENST00000306376.5	-	8	1137	c.891G>A	c.(889-891)cgG>cgA	p.R297R	ETV5_ENST00000434744.1_Silent_p.R297R|ETV5_ENST00000537818.1_Silent_p.R339R	NM_004454.2	NP_004445.1	P41161	ETV5_HUMAN	ets variant 5	297					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(2)|cervix(1)|large_intestine(7)|lung(9)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	28	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			CGCAGTAATCCCGAGGCTCCT	0.507000			T	"""TMPRSS2, SCL45A3"""	Prostate								65	136					0	0	0.003610	0	0
NPY5R	4889	broad.mit.edu	37	4	164272606	164272606	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:164272606A>T	ENST00000515560.1	+	4	2703	c.1181A>T	c.(1180-1182)aAt>aTt	p.N394I	NPY5R_ENST00000338566.3_Missense_Mutation_p.N394I|NPY5R_ENST00000506953.1_Missense_Mutation_p.N394I			Q15761	NPY5R_HUMAN	neuropeptide Y receptor Y5	394					cardiac left ventricle morphogenesis|outflow tract morphogenesis	integral to plasma membrane				NS(2)|biliary_tract(1)|breast(1)|endometrium(3)|large_intestine(4)|lung(26)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	all_hematologic(180;0.166)	Prostate(90;0.109)				ACTGATTTTAATGACAATCTT	0.353000													23	32					0	0	0.001882	0	0
NGRN	51335	broad.mit.edu	37	15	90814640	90814640	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:90814640G>A	ENST00000379095.3	+	3	504	c.496G>A	c.(496-498)Ggc>Agc	p.G166S	RP11-697E2.6_ENST00000561573.1_3'UTR|NGRN_ENST00000331497.3_3'UTR	NM_001033088.1	NP_001028260.2	Q9NPE2	NGRN_HUMAN	neugrin, neurite outgrowth associated	166					neuron differentiation	extracellular region|nucleus				kidney(2)|large_intestine(4)|lung(2)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	11	Melanoma(11;0.00551)|Lung NSC(78;0.0178)|all_lung(78;0.0378)		KIRC - Kidney renal clear cell carcinoma(17;0.0286)|BRCA - Breast invasive adenocarcinoma(143;0.0323)|Kidney(142;0.0514)			GCTCCCTGCAGGCCACTCTGT	0.512000													21	33					0	0	0.002780	0	0
FA2H	79152	broad.mit.edu	37	16	74752958	74752958	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:74752958G>C	ENST00000219368.3	-	5	783	c.714C>G	c.(712-714)ttC>ttG	p.F238L	FA2H_ENST00000544337.1_Missense_Mutation_p.F25L	NM_024306.4	NP_077282.3	Q7L5A8	FA2H_HUMAN	fatty acid 2-hydroxylase	238					cell death|electron transport chain|fatty acid biosynthetic process|sphingolipid metabolic process|transport	endoplasmic reticulum membrane|integral to membrane|microsome	heme binding|oxidoreductase activity			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						GCTTCATGTGGAACAGGAAGC	0.612000													15	40					0	0	0.002450	0	0
EBF3	253738	broad.mit.edu	37	10	131761695	131761695	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:131761695T>C	ENST00000368648.3	-	2	299	c.227A>G	c.(226-228)gAt>gGt	p.D76G	EBF3_ENST00000355311.5_Missense_Mutation_p.D76G	NM_001005463.2	NP_001005463.1	Q9H4W6	COE3_HUMAN	early B-cell factor 3	76					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	44		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		CCCCTGCCTATCGTAGAGCGC	0.572000													39	60					0	0	0.002222	0	0
CDHR1	92211	broad.mit.edu	37	10	85972966	85972966	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:85972966C>T	ENST00000372117.3	+	16	2005	c.1902C>T	c.(1900-1902)tcC>tcT	p.S634S	CDHR1_ENST00000332904.3_Silent_p.S634S|CDHR1_ENST00000440770.2_Silent_p.S338S	NM_033100.2	NP_149091.1	Q96JP9	CDHR1_HUMAN	cadherin-related family member 1	634	Cadherin 6.				homophilic cell adhesion		calcium ion binding|receptor activity			breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(21)|ovary(1)|prostate(1)|skin(1)	36						TCAAGAATTCCATCCGCTCCC	0.582000													30	36					0	0	0.001786	0	0
MFSD4	148808	broad.mit.edu	37	1	205549855	205549855	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:205549855G>A	ENST00000367147.4	+	3	589	c.496G>A	c.(496-498)Gag>Aag	p.E166K	MFSD4_ENST00000536357.1_Intron|MFSD4_ENST00000539267.1_Missense_Mutation_p.E166K	NM_181644.4	NP_857595.3	Q8N468	MFSD4_HUMAN	major facilitator superfamily domain containing 4	166					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	Breast(84;0.07)		BRCA - Breast invasive adenocarcinoma(75;0.0908)			TTTCCTGTCTGAGGCCAACTG	0.617000													110	42					0	0	0.003610	0	0
GPRIN3	285513	broad.mit.edu	37	4	90171111	90171111	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:90171111G>A	ENST00000333209.3	-	2	669	c.151C>T	c.(151-153)Cct>Tct	p.P51S		NM_198281.2	NP_938022.2	Q6ZVF9	GRIN3_HUMAN	GPRIN family member 3	51										breast(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(15)|ovary(5)|prostate(2)|skin(1)	36		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;5.67e-05)		GGTTCTGCAGGGGCACCTGAA	0.562000													32	32					0	0	0.002096	0	0
ACSS3	79611	broad.mit.edu	37	12	81536964	81536964	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:81536964C>T	ENST00000548058.1	+	5	1769	c.859C>T	c.(859-861)Cct>Tct	p.P287S	ACSS3_ENST00000261206.3_Missense_Mutation_p.P286S			Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	287						mitochondrion	acetate-CoA ligase activity|ATP binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(7)|liver(3)|lung(20)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)	51						TGACTGTGTTCCTGTTCTTTC	0.448000													18	44					0	0	0.007413	0	0
RELN	5649	broad.mit.edu	37	7	103216024	103216024	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:103216024C>T	ENST00000428762.1	-	29	4433	c.4274G>A	c.(4273-4275)gGa>gAa	p.G1425E	RELN_ENST00000424685.2_Missense_Mutation_p.G1425E|RELN_ENST00000343529.5_Missense_Mutation_p.G1425E	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1425	EGF-like 3.				axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GAAACACACTCCTGAAATGCA	0.438000													18	30					0	0	0.001523	0	0
ZDHHC19	131540	broad.mit.edu	37	3	195936327	195936327	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:195936327G>A	ENST00000296326.3	-	3	407	c.328C>T	c.(328-330)Cgc>Tgc	p.R110C	ZDHHC19_ENST00000488508.1_5'UTR	NM_001039617.1	NP_001034706.1	Q8WVZ1	ZDH19_HUMAN	zinc finger, DHHC-type containing 19	110						integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(7)|ovary(3)	14	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.89e-25)|all cancers(36;1.46e-23)|OV - Ovarian serous cystadenocarcinoma(49;2.1e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0022)		CATTGCAGGCGGAAGGCCCCG	0.652000													4	19					0	0	0.000248	0	0
ALG14	199857	broad.mit.edu	37	1	95538372	95538372	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:95538372G>A	ENST00000370205.4	-	1	129	c.83C>T	c.(82-84)tCc>tTc	p.S28F	ALG14_ENST00000495856.1_5'UTR	NM_144988.3	NP_659425.1	Q96F25	ALG14_HUMAN	ALG14, UDP-N-acetylglucosaminyltransferase subunit	28					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity			endometrium(2)|large_intestine(1)|lung(2)|pancreas(1)	6		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.0615)|Epithelial(280;0.139)		AACGTCCATGGAACGAAGCAC	0.562000													27	28					0	0	0.007291	0	0
PDP2	57546	broad.mit.edu	37	16	66918222	66918222	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:66918222C>T	ENST00000311765.2	+	2	369	c.35C>T	c.(34-36)tCt>tTt	p.S12F	PDP2_ENST00000568720.1_Intron	NM_020786.2	NP_065837.1	Q9P2J9	PDP2_HUMAN	pyruvate dehyrogenase phosphatase catalytic subunit 2	12					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity|metal ion binding			kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|urinary_tract(1)	12		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		ATCTTAAATTCTACAAGGAAC	0.373000													42	191					0	0	0.002522	0	0
BDKRB2	624	broad.mit.edu	37	14	96707723	96707723	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:96707723A>C	ENST00000542454.2	+	3	4065	c.977A>C	c.(976-978)aAa>aCa	p.K326T	RP11-404P21.8_ENST00000553811.1_Intron|BDKRB2_ENST00000554311.1_Missense_Mutation_p.K353T|BDKRB2_ENST00000539359.1_Missense_Mutation_p.K326T|BDKRB2_ENST00000306005.3_Missense_Mutation_p.K353T			P30411	BKRB2_HUMAN	bradykinin receptor B2	353					arachidonic acid secretion|elevation of cytosolic calcium ion concentration|transmembrane receptor protein tyrosine kinase signaling pathway	endosome|integral to plasma membrane	bradykinin receptor activity|phosphatidylinositol phospholipase C activity|protease binding|protein heterodimerization activity|type 1 angiotensin receptor binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(5)|lung(7)|ovary(3)|skin(1)	24		all_cancers(154;0.0678)|Melanoma(154;0.155)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.226)		GTGTGCCAGAAAGGGGGCTGC	0.572000													8	26					0	0	0.000673	0	0
RFFL	117584	broad.mit.edu	37	17	33348531	33348531	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:33348531G>A	ENST00000315249.7	-	3	672	c.450C>T	c.(448-450)acC>acT	p.T150T	RFFL_ENST00000447669.2_Silent_p.T150T|RFFL_ENST00000413582.2_Silent_p.T150T|RFFL_ENST00000394597.2_Silent_p.T150T|RFFL_ENST00000378516.2_Silent_p.T150T|RFFL_ENST00000268850.7_Silent_p.T150T|RAD51L3-RFFL_ENST00000593039.1_Intron|RFFL_ENST00000415395.2_Silent_p.T150T|RFFL_ENST00000584655.1_Silent_p.T150T			Q8WZ73	RFFL_HUMAN	ring finger and FYVE-like domain containing E3 ubiquitin protein ligase	150					apoptosis	membrane	ligase activity|zinc ion binding			kidney(1)|large_intestine(2)|lung(3)	6		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0227)		CTGGGGACAAGGTGGAGGCAC	0.577000													10	9					0	0	0.006214	0	0
TDRD6	221400	broad.mit.edu	37	6	46660298	46660298	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:46660298C>T	ENST00000544460.1	+	1	4687	c.4433C>T	c.(4432-4434)gCt>gTt	p.A1478V	TDRD6_ENST00000316081.6_Missense_Mutation_p.A1478V	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1478					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			AGCAGGTATGCTCTCAGTGAA	0.348000													24	111					0	0	0.003330	0	0
LPHN3	23284	broad.mit.edu	37	4	62845460	62845460	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:62845460C>T	ENST00000512091.1	+	17	3528	c.2781C>T	c.(2779-2781)ttC>ttT	p.F927F	LPHN3_ENST00000509896.1_Silent_p.F995F|LPHN3_ENST00000511324.1_Silent_p.F995F|LPHN3_ENST00000508693.1_Silent_p.F995F|LPHN3_ENST00000506746.1_Silent_p.F995F|LPHN3_ENST00000545650.1_Silent_p.F927F|LPHN3_ENST00000507164.1_Silent_p.F995F|LPHN3_ENST00000506720.1_Silent_p.F995F|LPHN3_ENST00000514996.1_Silent_p.F927F|LPHN3_ENST00000514591.1_Silent_p.F927F|LPHN3_ENST00000514157.1_Silent_p.F927F|LPHN3_ENST00000508946.1_Silent_p.F927F|LPHN3_ENST00000506700.1_Silent_p.F927F|LPHN3_ENST00000507625.1_Silent_p.F995F|LPHN3_ENST00000504896.1_Silent_p.F927F			Q9HAR2	LPHN3_HUMAN	latrophilin 3	914					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			breast(5)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(4)|large_intestine(21)|lung(73)|ovary(1)|pancreas(1)|prostate(6)|upper_aerodigestive_tract(1)	125						AGCTGCTCTTCCTGATTGGGA	0.453000													38	141					0	0	0.005524	0	0
COL22A1	169044	broad.mit.edu	37	8	139674289	139674289	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:139674289C>T	ENST00000303045.6	-	43	3670	c.3224G>A	c.(3223-3225)gGc>gAc	p.G1075D	COL22A1_ENST00000341807.4_5'UTR|COL22A1_ENST00000435777.1_Missense_Mutation_p.G1055D	NM_152888.1	NP_690848.1	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1075	Collagen-like 9.|Gly-rich.|Pro-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(14)|large_intestine(29)|lung(107)|ovary(13)|pancreas(1)|prostate(3)|skin(12)|upper_aerodigestive_tract(15)|urinary_tract(4)	211	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			GCCGGCTGGGCCCTGGGGGCC	0.547000										HNSCC(7;0.00092)			14	114					0	0	0.002450	0	0
MUC16	94025	broad.mit.edu	37	19	9061543	9061543	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9061543C>T	ENST00000397910.4	-	3	26106	c.25903G>A	c.(25903-25905)Gat>Aat	p.D8635N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8637	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTCTCTCTATCTTTGGTGACT	0.438000													24	27					0	0	0.003330	0	0
GPD2	2820	broad.mit.edu	37	2	157425455	157425455	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:157425455C>T	ENST00000310454.6	+	10	1656	c.1284C>T	c.(1282-1284)ggC>ggT	p.G428G	GPD2_ENST00000409674.1_Silent_p.G428G|GPD2_ENST00000409125.4_Silent_p.G201G|GPD2_ENST00000540309.1_Intron|GPD2_ENST00000438166.2_Silent_p.G428G	NM_001083112.2	NP_001076581.2	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2 (mitochondrial)	428					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(1)|stomach(1)	22						GTGAGAGTGGCCTTATTACTA	0.413000													43	61					0	0	0.003610	0	0
EPHB1	2047	broad.mit.edu	37	3	134670723	134670723	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:134670723G>A	ENST00000398015.3	+	3	1004	c.634G>A	c.(634-636)Ggg>Agg	p.G212R	EPHB1_ENST00000488154.1_Intron	NM_004441.4	NP_004432.1	P54762	EPHB1_HUMAN	EPH receptor B1	212	Cys-rich.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(13)|lung(63)|ovary(8)|pancreas(2)|prostate(8)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(2)	130						GACTATGACAGGGGCAGAGAG	0.507000													66	151					0	0	0.003610	0	0
ITGAL	3683	broad.mit.edu	37	16	30516772	30516772	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:30516772C>T	ENST00000356798.6	+	20	2535	c.2355C>T	c.(2353-2355)ttC>ttT	p.F785F	ITGAL_ENST00000358164.5_Silent_p.F701F|ITGAL_ENST00000433423.2_Intron	NM_002209.2	NP_002200.2	P20701	ITAL_HUMAN	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	785					blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(10)|kidney(4)|large_intestine(12)|lung(32)|ovary(3)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	76					Efalizumab(DB00095)	GAGTGTCCTTCTCTCCTGCAA	0.507000													21	46					0	0	0.001523	0	0
FGF12	2257	broad.mit.edu	37	3	192125915	192125915	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:192125915G>A	ENST00000454309.2	-	1	923	c.98C>T	c.(97-99)cCc>cTc	p.P33L	FGF12_ENST00000445105.1_Intron|FGF12_ENST00000430714.1_Intron|FGF12_ENST00000264730.3_Intron|FGF12_ENST00000450716.1_Intron	NM_021032.4	NP_066360.1	P61328	FGF12_HUMAN	fibroblast growth factor 12	33					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	30	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		GTCTTTGCTGGGGCTGGAGCG	0.677000													34	56					0	0	0.003271	0	0
AREL1	9870	broad.mit.edu	37	14	75136688	75136688	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:75136688A>T	ENST00000356357.4	-	14	2265	c.1750T>A	c.(1750-1752)Ttc>Atc	p.F584I	AREL1_ENST00000557401.1_5'UTR	NM_001039479.1	NP_001034568.1			apoptosis resistant E3 ubiquitin protein ligase 1																		TGGGCCAGGAAAGAGCGGGTG	0.517000													23	29					0	0	0.002780	0	0
MYOCD	93649	broad.mit.edu	37	17	12656388	12656388	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:12656388G>A	ENST00000425538.1	+	10	1983	c.1783G>A	c.(1783-1785)Gag>Aag	p.E595K	MYOCD_ENST00000343344.4_Missense_Mutation_p.E595K|MYOCD_ENST00000395988.1_Missense_Mutation_p.E499K	NM_001146312.1|NM_153604.2	NP_001139784.1|NP_705832.1	Q8IZQ8	MYCD_HUMAN	myocardin	595					cardiac muscle cell differentiation|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|positive regulation of smooth muscle cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation|regulation of histone acetylation|smooth muscle cell differentiation	nucleus	nucleic acid binding|RNA polymerase II transcription factor binding transcription factor activity|transcription factor binding			breast(2)|central_nervous_system(2)|endometrium(5)|kidney(2)|large_intestine(11)|liver(2)|lung(33)|ovary(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	70				UCEC - Uterine corpus endometrioid carcinoma (92;0.0969)		CAGCAGCTCAGAGTGTCACCC	0.517000													27	39					0	0	0.002096	0	0
TET1	80312	broad.mit.edu	37	10	70405173	70405173	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:70405173C>T	ENST00000373644.4	+	4	2896	c.2687C>T	c.(2686-2688)gCc>gTc	p.A896V		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	896					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						GCCATAGAGGCCCTGACTCAA	0.448000													43	62					0	0	0.003610	0	0
FBXL6	26233	broad.mit.edu	37	8	145579751	145579751	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:145579751T>G	ENST00000331890.5	-	8	1413	c.1349A>C	c.(1348-1350)cAg>cCg	p.Q450P	FBXL6_ENST00000526524.1_Intron|FBXL6_ENST00000455319.2_Missense_Mutation_p.Q444P	NM_012162.2	NP_036294.1	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6	450					proteolysis		ubiquitin-protein ligase activity			endometrium(1)|lung(3)|ovary(1)	5	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			ACTGAACCCCTGGCCACTCAA	0.607000													63	126					0	0	0.003610	0	0
HSD17B13	345275	broad.mit.edu	37	4	88235068	88235068	+	Missense_Mutation	SNP	G	G	A	rs142648167	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:88235068G>A	ENST00000328546.4	-	5	666	c.602C>T	c.(601-603)tCa>tTa	p.S201L	HSD17B13_ENST00000302219.6_Missense_Mutation_p.S165L	NM_178135.3	NP_835236.2	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	201						extracellular region	binding|oxidoreductase activity			endometrium(1)|large_intestine(3)|lung(2)|prostate(1)|urinary_tract(1)	8		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		CTGAAGTTCTGATGTCAGACC	0.433000													13	15					0	0	0.001855	0	0
TRO	7216	broad.mit.edu	37	X	54957352	54957352	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:54957352G>A	ENST00000173898.7	+	12	4307	c.4195G>A	c.(4195-4197)Gga>Aga	p.G1399R	TRO_ENST00000319167.8_Intron|TRO_ENST00000399736.1_Intron|TRO_ENST00000420798.2_Missense_Mutation_p.G930R|TRO_ENST00000375041.2_Missense_Mutation_p.G1002R|TRO_ENST00000375022.4_Intron	NM_001039705.1	NP_001034794.1	Q12816	TROP_HUMAN	trophinin	1399	62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|skin(2)|urinary_tract(1)	37						CTTCGGCGGTGGACCAAACAC	0.617000													29	3					0	0	0.001512	0	0
PPP3CC	5533	broad.mit.edu	37	8	22370923	22370923	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:22370923C>T	ENST00000240139.5	+	6	1075	c.748C>T	c.(748-750)Cga>Tga	p.R250*	PPP3CC_ENST00000397775.3_Nonsense_Mutation_p.R250*|PPP3CC_ENST00000289963.8_Nonsense_Mutation_p.R250*|PPP3CC_ENST00000518852.1_Nonsense_Mutation_p.R250*	NM_005605.4	NP_005596.2	P48454	PP2BC_HUMAN	protein phosphatase 3, catalytic subunit, gamma isozyme	250					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals	cytosol	calmodulin binding|metal ion binding|phosphoprotein phosphatase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	17		Prostate(55;0.104)		BRCA - Breast invasive adenocarcinoma(99;0.00756)|Colorectal(74;0.0238)|COAD - Colon adenocarcinoma(73;0.0835)		CAACACTGTCCGAGGGTGCTC	0.428000													45	78					0	0	0.003610	0	0
TDRD6	221400	broad.mit.edu	37	6	46665773	46665773	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:46665773C>T	ENST00000316081.6	+	3	6210	c.6210C>T	c.(6208-6210)aaC>aaT	p.N2070N	TDRD6_ENST00000544460.1_Intron	NM_001010870.2	NP_001010870.1	O60522	TDRD6_HUMAN	tudor domain containing 6	2070	Tudor 8.				cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			AGATAGTGAACCCTGAGAATG	0.338000													49	297					0	0	0.003610	0	0
PPP1R32	220004	broad.mit.edu	37	11	61250166	61250166	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:61250166G>A	ENST00000338608.2	+	4	392	c.267G>A	c.(265-267)caG>caA	p.Q89Q	PPP1R32_ENST00000432063.2_Silent_p.Q89Q|RP11-286N22.8_ENST00000544880.1_Intron	NM_145017.2	NP_659454.2	Q7Z5V6	CK066_HUMAN	protein phosphatase 1, regulatory subunit 32	89																	TGGCCAGCCAGAGCTACCGCC	0.652000											OREG0021002	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	16	17					0	0	0.006122	0	0
P2RX3	5024	broad.mit.edu	37	11	57137411	57137411	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57137411G>A	ENST00000263314.2	+	12	1169	c.1135G>A	c.(1135-1137)Gac>Aac	p.D379N		NM_002559.3	NP_002550.2	P56373	P2RX3_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 3	379					positive regulation of calcium ion transport into cytosol|positive regulation of calcium-mediated signaling	integral to plasma membrane	ATP binding|extracellular ATP-gated cation channel activity|purinergic nucleotide receptor activity			endometrium(4)|kidney(2)|large_intestine(4)|lung(15)|prostate(1)	26						GTACCCCAGCGACCAGACCAC	0.577000													8	43					0	0	0.000978	0	0
RTN4	57142	broad.mit.edu	37	2	55200750	55200750	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:55200750A>T	ENST00000337526.6	-	8	3728	c.3485T>A	c.(3484-3486)aTa>aAa	p.I1162K	RTN4_ENST00000404909.1_Missense_Mutation_p.I956K|RTN4_ENST00000402434.2_Missense_Mutation_p.I315K|RTN4_ENST00000357376.3_Missense_Mutation_p.I956K|RTN4_ENST00000394611.2_Missense_Mutation_p.I956K|RTN4_ENST00000405240.1_Missense_Mutation_p.I956K|RTN4_ENST00000354474.6_Missense_Mutation_p.I930K|RTN4_ENST00000486085.1_5'UTR|RTN4_ENST00000317610.7_Missense_Mutation_p.I343K|RTN4_ENST00000394609.2_Missense_Mutation_p.I169K|RTN4_ENST00000357732.4_Missense_Mutation_p.I362K	NM_020532.4	NP_065393.1	Q9NQC3	RTN4_HUMAN	reticulon 4	1162	Reticulon.				apoptosis|axonal fasciculation|cerebral cortex radial glia guided migration|endoplasmic reticulum tubular network organization|negative regulation of anti-apoptosis|negative regulation of axon extension|nerve growth factor receptor signaling pathway|regulation of apoptosis|regulation of branching morphogenesis of a nerve|regulation of cell migration	integral to endoplasmic reticulum membrane|nuclear envelope|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(11)|lung(9)|ovary(2)|prostate(1)|skin(1)|stomach(1)	36						ATAATGATCTATCTGTGCCTG	0.343000													35	27					0	0	0.007835	0	0
PTK2	5747	broad.mit.edu	37	8	141889609	141889609	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:141889609C>T	ENST00000522684.1	-	4	552	c.323G>A	c.(322-324)aGg>aAg	p.R108K	PTK2_ENST00000340930.3_Missense_Mutation_p.R108K|PTK2_ENST00000535192.1_Missense_Mutation_p.R108K|PTK2_ENST00000521059.1_Missense_Mutation_p.R108K|PTK2_ENST00000519881.1_Missense_Mutation_p.R108K|PTK2_ENST00000517887.1_Missense_Mutation_p.R152K|PTK2_ENST00000520892.1_Missense_Mutation_p.R108K|PTK2_ENST00000519419.1_Missense_Mutation_p.R152K|PTK2_ENST00000395218.2_Missense_Mutation_p.R108K	NM_153831.3	NP_722560.1	Q05397	FAK1_HUMAN	protein tyrosine kinase 2	108	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(6)|lung(23)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	48	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			ATACTTCTCCCTCACACTGGA	0.483000													86	243					0	0	0.003610	0	0
NT5C1B	93034	broad.mit.edu	37	2	18768804	18768804	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:18768804C>T	ENST00000304081.4	-	2	185	c.85G>A	c.(85-87)Gaa>Aaa	p.E29K	NT5C1B_ENST00000460052.1_5'UTR|NT5C1B_ENST00000600945.1_Missense_Mutation_p.E29K|NT5C1B-RDH14_ENST00000532967.1_Missense_Mutation_p.E29K|NT5C1B_ENST00000359846.2_Missense_Mutation_p.E29K	NM_033253.3	NP_150278.2			5'-nucleotidase, cytosolic IB											endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	29	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				TTGTCAGATTCCTTTCTTTTT	0.393000													34	80					0	0	0.005524	0	0
ADAM12	8038	broad.mit.edu	37	10	127755328	127755328	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:127755328C>T	ENST00000368679.4	-	13	1689	c.1380G>A	c.(1378-1380)ccG>ccA	p.P460P	ADAM12_ENST00000368676.4_Silent_p.P460P|ADAM12_ENST00000467145.1_5'UTR	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	460	Disintegrin.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		ACACAGCGTCCGGCTTCAGGG	0.552000													11	18					0	0	0.000978	0	0
HIST1H2AA	221613	broad.mit.edu	37	6	25726745	25726745	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:25726745C>T	ENST00000297012.3	-	1	45	c.11G>A	c.(10-12)cGa>cAa	p.R4Q		NM_170745.3	NP_734466.1	Q96QV6	H2A1A_HUMAN	histone cluster 1, H2aa	4					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|endometrium(2)|large_intestine(2)|lung(8)	13						CTGCTTCCCTCGTCCAGACAT	0.522000													16	115					0	0	0.001216	0	0
DMTN	2039	broad.mit.edu	37	8	21938632	21938632	+	Silent	SNP	C	C	T	rs146626785		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:21938632C>T	ENST00000358242.3	+	15	1525	c.1032C>T	c.(1030-1032)ccC>ccT	p.P344P	DMTN_ENST00000517600.1_Silent_p.P304P|DMTN_ENST00000381470.3_Silent_p.P322P|DMTN_ENST00000523266.1_Silent_p.P344P|DMTN_ENST00000519907.1_Silent_p.P322P|DMTN_ENST00000265800.5_Silent_p.P344P|DMTN_ENST00000523782.2_Silent_p.P297P|DMTN_ENST00000443491.2_Silent_p.P297P|DMTN_ENST00000432128.1_Silent_p.P344P|DMTN_ENST00000415253.1_Silent_p.P322P					dematin actin binding protein																		AGATCTATCCCTATGAAATGC	0.587000													14	39					0	0	0.001855	0	0
ZNF154	7710	broad.mit.edu	37	19	58213274	58213274	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:58213274C>T	ENST00000512439.2	-	3	1239	c.1043G>A	c.(1042-1044)cGg>cAg	p.R348Q	AC003006.7_ENST00000596085.1_Intron|AC003006.7_ENST00000599221.1_Intron|ZNF154_ENST00000426889.1_Missense_Mutation_p.R348Q			Q13106	ZN154_HUMAN	zinc finger protein 154	348						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(3)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GTGAACTCCCCGATGTTGAAG	0.498000													22	63					0	0	0.001882	0	0
CNGA3	1261	broad.mit.edu	37	2	99013680	99013680	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:99013680C>T	ENST00000393504.1	+	8	2464	c.2047C>T	c.(2047-2049)Ccc>Tcc	p.P683S	CNGA3_ENST00000436404.2_Missense_Mutation_p.P665S|CNGA3_ENST00000409937.1_Missense_Mutation_p.P687S|CNGA3_ENST00000272602.2_Missense_Mutation_p.P683S	NM_001298.2	NP_001289.1	Q16281	CNGA3_HUMAN	cyclic nucleotide gated channel alpha 3	683					signal transduction|visual perception	integral to membrane	cGMP binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(17)|ovary(5)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	49						TGGGGAAGTTCCCGGGGATGC	0.552000													10	24					0	0	0.001368	0	0
SERPINB3	6317	broad.mit.edu	37	18	61323156	61323156	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:61323156C>T	ENST00000283752.5	-	8	1051	c.908G>A	c.(907-909)gGa>gAa	p.G303E	SERPINB11_ENST00000489748.1_RNA|SERPINB3_ENST00000332821.8_Missense_Mutation_p.G251E	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	303					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						ATCCACCATTCCCATGGTTCT	0.502000													25	46					0	0	0.001512	0	0
PTPRA	5786	broad.mit.edu	37	20	3005267	3005267	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:3005267G>A	ENST00000216877.6	+	16	1987	c.1587_splice	c.e16+1	p.K529_splice	PTPRA_ENST00000356147.3_Splice_Site_p.K529_splice|PTPRA_ENST00000380393.3_Splice_Site_p.K538_splice|PTPRA_ENST00000425918.2_Splice_Site_p.K549_splice|PTPRA_ENST00000358719.4_Splice_Site_p.K394_splice|PTPRA_ENST00000318266.5_Splice_Site_p.K529_splice|PTPRA_ENST00000399903.2_Splice_Site_p.K538_splice	NM_080840.2	NP_543030.1	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	538					axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						AGGAGTTTAAGGTGAGTTGGA	0.458000													33	70					0	0	0.002445	0	0
SUPT5H	6829	broad.mit.edu	37	19	39961136	39961136	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:39961136C>T	ENST00000599117.1	+	19	2017	c.1650C>T	c.(1648-1650)atC>atT	p.I550I	SUPT5H_ENST00000359191.6_Silent_p.I546I|SUPT5H_ENST00000598725.1_Silent_p.I550I|SUPT5H_ENST00000432763.2_Silent_p.I550I|SUPT5H_ENST00000402194.2_Silent_p.I546I			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	550					cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			TGGGTGTCATCGTGCGACTAG	0.592000													49	118					0	0	0.003610	0	0
KRTAP10-12	386685	broad.mit.edu	37	21	46117527	46117527	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:46117527C>T	ENST00000400365.3	+	1	441	c.411C>T	c.(409-411)tgC>tgT	p.C137C	TSPEAR_ENST00000323084.4_Intron	NM_198699.1	NP_941972.1	P60413	KR10C_HUMAN	keratin associated protein 10-12	137	19 X 5 AA repeats of C-C-X(3).					keratin filament				large_intestine(1)|lung(8)	9						AGTCTAGCTGCCAGCCAGCTT	0.617000													41	47					0	0	0.006230	0	0
PDCD6IP	10015	broad.mit.edu	37	3	33893999	33893999	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:33893999C>T	ENST00000307296.3	+	13	2038	c.1661C>T	c.(1660-1662)tCc>tTc	p.S554F	PDCD6IP_ENST00000457054.2_Missense_Mutation_p.S559F			Q8WUM4	PDC6I_HUMAN	programmed cell death 6 interacting protein	554	Interaction with EIAV p9.|Self-association.				apoptosis|cell cycle|cell division|interspecies interaction between organisms|protein transport	cytosol|melanosome|microtubule organizing center	calcium-dependent protein binding			central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|skin(1)|stomach(1)	23						GTCTTAAAATCCTTATTGTCA	0.303000													7	25					0	0	0.000673	0	0
C19orf70	125988	broad.mit.edu	37	19	5679657	5679657	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:5679657G>A	ENST00000309324.4	-	2	556	c.147C>T	c.(145-147)ccC>ccT	p.P49P	C19orf70_ENST00000587950.1_Silent_p.P71P|C19orf70_ENST00000587589.1_Silent_p.P49P|C19orf70_ENST00000585605.1_5'UTR|C19orf70_ENST00000590389.1_Silent_p.P71P|RPL36_ENST00000579649.1_Intron	NM_205767.1	NP_991330.1	Q5XKP0	QIL1_HUMAN	chromosome 19 open reading frame 70	49							protein binding			endometrium(1)|lung(1)	2						ACATGGCGGGGGGGACCACCT	0.667000													15	30					0	0	0.006122	0	0
FA2H	79152	broad.mit.edu	37	16	74752957	74752957	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:74752957G>A	ENST00000219368.3	-	5	784	c.715C>T	c.(715-717)Cac>Tac	p.H239Y	FA2H_ENST00000544337.1_Missense_Mutation_p.H26Y	NM_024306.4	NP_077282.3	Q7L5A8	FA2H_HUMAN	fatty acid 2-hydroxylase	239					cell death|electron transport chain|fatty acid biosynthetic process|sphingolipid metabolic process|transport	endoplasmic reticulum membrane|integral to membrane|microsome	heme binding|oxidoreductase activity			endometrium(2)|large_intestine(4)|lung(3)|skin(1)	10						GGCTTCATGTGGAACAGGAAG	0.617000													16	39					0	0	0.003163	0	0
TOP2A	7153	broad.mit.edu	37	17	38546331	38546331	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:38546331G>A	ENST00000423485.1	-	34	4511	c.4353C>T	c.(4351-4353)gtC>gtT	p.V1451V		NM_001067.3	NP_001058.2	P11388	TOP2A_HUMAN	topoisomerase (DNA) II alpha 170kDa	1451					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(9)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)	39		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	GCTTTTGAGAGACACCAGAAT	0.443000													13	16					0	0	0.001855	0	0
ZNF318	24149	broad.mit.edu	37	6	43322651	43322651	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43322651G>A	ENST00000361428.2	-	4	2498	c.2421C>T	c.(2419-2421)acC>acT	p.T807T	ZNF318_ENST00000318149.3_Silent_p.T807T	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	807					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			ACGGTTGAGAGGTGGGATACA	0.527000													22	93					0	0	0.001882	0	0
WDR65	149465	broad.mit.edu	37	1	43649261	43649261	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:43649261G>A	ENST00000372492.4	+	4	798		c.e4-1		WDR65_ENST00000528956.1_Splice_Site	NM_001195831.2	NP_001182760.2	Q96MR6	WDR65_HUMAN	WD repeat domain 65											NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACATTTTACAGGTGAGCTTCA	0.373000													22	34					0	0	0.002780	0	0
GPR179	440435	broad.mit.edu	37	17	36493589	36493589	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:36493589C>T	ENST00000342292.4	-	3	938	c.918G>A	c.(916-918)gaG>gaA	p.E306E		NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	306						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AGCCCTGACTCTCCAGGGGAA	0.572000													38	18					0	0	0.007835	0	0
CYP2W1	54905	broad.mit.edu	37	7	1024668	1024668	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:1024668G>A	ENST00000340150.6	+	3	274	c.252G>A	c.(250-252)cgG>cgA	p.R84R	CYP2W1_ENST00000308919.7_Silent_p.R140R			Q8TAV3	CP2W1_HUMAN	cytochrome P450, family 2, subfamily W, polypeptide 1	140					xenobiotic metabolic process	endoplasmic reticulum membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen			breast(1)|large_intestine(1)|lung(4)|urinary_tract(1)	7		Ovarian(82;0.0112)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		GCGTGGGCCGGGAGCCGGTGG	0.672000													9	74					0	0	0.004482	0	0
TMPRSS11A	339967	broad.mit.edu	37	4	68795664	68795664	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:68795664T>G	ENST00000508048.1	-	5	447	c.412A>C	c.(412-414)Atc>Ctc	p.I138L	RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11A_ENST00000334830.7_Missense_Mutation_p.I142L|TMPRSS11A_ENST00000396188.2_Missense_Mutation_p.I139L			Q6ZMR5	TM11A_HUMAN	transmembrane protease, serine 11A	142	SEA.				cell cycle|proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|cervix(2)|kidney(1)|large_intestine(8)|lung(11)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	29						TGATTTAAGATGCTTTGGATT	0.403000													34	36					0	0	0.003271	0	0
PPIC	5480	broad.mit.edu	37	5	122361629	122361629	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:122361629C>T	ENST00000306442.4	-	4	475	c.360G>A	c.(358-360)gaG>gaA	p.E120E		NM_000943.4	NP_000934.1	P45877	PPIC_HUMAN	peptidylprolyl isomerase C (cyclophilin C)	120	PPIase cyclophilin-type.				protein folding|signal transduction	cytoplasm	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity|unfolded protein binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|urinary_tract(1)	6		all_cancers(142;0.0168)|Prostate(80;0.0322)|Lung NSC(810;0.102)|all_lung(232;0.163)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000331)|Epithelial(69;0.000553)|all cancers(49;0.00505)	L-Proline(DB00172)	GCTTGAAGTTCTCATCTGGAA	0.473000													4	36					0	0	0.000248	0	0
RUNX2	860	broad.mit.edu	37	6	45514872	45514872	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:45514872C>T	ENST00000371438.1	+	8	1754	c.1396C>T	c.(1396-1398)Cct>Tct	p.P466S	RUNX2_ENST00000371432.3_Missense_Mutation_p.P430S|RUNX2_ENST00000359524.5_Missense_Mutation_p.P452S|RUNX2_ENST00000576263.1_Intron|RUNX2_ENST00000352853.5_Missense_Mutation_p.P534S|RUNX2_ENST00000541979.1_Missense_Mutation_p.P512S|RUNX2_ENST00000465038.2_Missense_Mutation_p.P466S|RUNX2_ENST00000371436.6_Missense_Mutation_p.P444S	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	466	Interaction with MYST4.|Pro/Ser/Thr-rich.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						AGACCGGTCTCCTTCCAGAAT	0.532000													18	90					0	0	0.004990	0	0
SRP54	6729	broad.mit.edu	37	14	35482571	35482571	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:35482571A>T	ENST00000556994.1	+	10	1053	c.656A>T	c.(655-657)tAt>tTt	p.Y219F	SRP54_ENST00000555557.1_Missense_Mutation_p.Y155F|SRP54_ENST00000216774.6_Missense_Mutation_p.Y219F|SRP54_ENST00000546080.1_Missense_Mutation_p.Y170F			P61011	SRP54_HUMAN	signal recognition particle 54kDa	219	G-domain.				GTP catabolic process|response to drug|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|SRP-dependent cotranslational protein targeting to membrane, translocation	cytosol|nuclear speck|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|drug binding|endoplasmic reticulum signal peptide binding|GDP binding|GTP binding|nucleoside-triphosphatase activity|ribonucleoprotein binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	14	Breast(36;0.0545)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;2.48e-05)|Lung(238;3.13e-05)|Epithelial(34;0.0314)|all cancers(34;0.0797)|BRCA - Breast invasive adenocarcinoma(188;0.243)	GBM - Glioblastoma multiforme(112;0.0396)		AACATTGTTTATGTGATGGAT	0.348000													18	29					0	0	0.002780	0	0
BTN2A3P	54718	broad.mit.edu	37	6	26423481	26423481	+	RNA	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:26423481G>A	ENST00000466808.2	+	0	400																											CTGCAATGAGGCCATCCTGCA	0.512000													10	85					0	0	0.000978	0	0
JMY	133746	broad.mit.edu	37	5	78610468	78610468	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:78610468C>T	ENST00000396137.4	+	9	2915	c.2453C>T	c.(2452-2454)cCc>cTc	p.P818L	JMY_ENST00000412001.1_Intron	NM_152405.4	NP_689618.4	Q8N9B5	JMY_HUMAN	junction mediating and regulatory protein, p53 cofactor	818	Pro-rich.				'de novo' actin filament nucleation|actin polymerization-dependent cell motility|Arp2/3 complex-mediated actin nucleation|cell cycle arrest|DNA repair|induction of apoptosis|positive regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter	cell leading edge|cytoplasm|cytoskeleton|nucleus	actin binding|transcription coactivator activity			endometrium(4)|kidney(2)|large_intestine(2)|lung(6)|skin(1)|urinary_tract(1)	16		all_lung(232;0.00051)|Lung NSC(167;0.00131)|Ovarian(174;0.0261)|Prostate(461;0.191)		OV - Ovarian serous cystadenocarcinoma(54;4.45e-45)|Epithelial(54;5.85e-40)|all cancers(79;2.89e-35)		ccacctcctccccctccccca	0.537000													25	14					0	0	0.004656	0	0
HTR3E	285242	broad.mit.edu	37	3	183822695	183822695	+	Silent	SNP	C	C	T	rs145422207		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:183822695C>T	ENST00000415389.2	+	5	976	c.510C>T	c.(508-510)ccC>ccT	p.P170P	HTR3E-AS1_ENST00000431427.1_RNA|HTR3E_ENST00000425359.2_Silent_p.P155P|HTR3E_ENST00000440596.2_Silent_p.P196P|HTR3E_ENST00000335304.2_Silent_p.P185P|HTR3E_ENST00000436361.2_Silent_p.P170P	NM_001256613.1|NM_198313.2	NP_001243542.1|NP_938055.1	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	170						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TCTACTTCCCCTTCGACCAGC	0.473000													19	69					0	0	0.001882	0	0
FLNB	2317	broad.mit.edu	37	3	58094218	58094218	+	Missense_Mutation	SNP	G	G	A	rs140945224		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:58094218G>A	ENST00000357272.4	+	13	2140	c.1975G>A	c.(1975-1977)Gga>Aga	p.G659R	FLNB_ENST00000493452.1_Missense_Mutation_p.G490R|FLNB_ENST00000429972.2_Missense_Mutation_p.G659R|FLNB_ENST00000419752.2_Missense_Mutation_p.G490R|FLNB_ENST00000490882.1_Missense_Mutation_p.G659R|FLNB_ENST00000295956.4_Missense_Mutation_p.G659R|FLNB_ENST00000348383.5_Missense_Mutation_p.G659R|FLNB_ENST00000358537.3_Missense_Mutation_p.G659R			O75369	FLNB_HUMAN	filamin B, beta	659					actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			NS(1)|breast(13)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(23)|liver(2)|lung(38)|ovary(6)|prostate(3)|skin(8)|upper_aerodigestive_tract(3)|urinary_tract(5)	120				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		GGAGAAATCTGGATGCATTGT	0.463000													12	30					0	0	0.002450	0	0
MOCS3	27304	broad.mit.edu	37	20	49576006	49576006	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:49576006G>A	ENST00000244051.1	+	1	644	c.627G>A	c.(625-627)gaG>gaA	p.E209E		NM_014484.3	NP_055299.1	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	209					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(2)|lung(8)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)	24						TGCGCTTCGAGGGCCAAATCA	0.617000													18	59					0	0	0.001216	0	0
SNX8	29886	broad.mit.edu	37	7	2297013	2297013	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2297013G>A	ENST00000222990.3	-	9	1163	c.1121C>T	c.(1120-1122)tCc>tTc	p.S374F		NM_013321.2	NP_037453.1	Q9Y5X2	SNX8_HUMAN	sorting nexin 8	374					cell communication|early endosome to Golgi transport|intracellular protein transport	early endosome membrane	phosphatidylinositol binding|protein binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(2)|skin(3)	26		Ovarian(82;0.11)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0853)|OV - Ovarian serous cystadenocarcinoma(56;3.79e-14)		CACAATGCGGGACTCCAGCTG	0.701000													8	22					0	0	0.006214	0	0
DTX4	23220	broad.mit.edu	37	11	58962828	58962828	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:58962828C>T	ENST00000227451.3	+	7	1626	c.1522C>T	c.(1522-1524)Ccc>Tcc	p.P508S	DTX4_ENST00000532982.1_Missense_Mutation_p.P402S	NM_015177.1	NP_055992.1	Q9Y2E6	DTX4_HUMAN	deltex homolog 4 (Drosophila)	508					Notch signaling pathway	cytoplasm	zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(1)|upper_aerodigestive_tract(1)	20		all_epithelial(135;0.125)				CTACAGCATCCCCCCCGGCAT	0.512000													8	31					0	0	0.003080	0	0
RNF216	54476	broad.mit.edu	37	7	5764962	5764962	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:5764962A>T	ENST00000425013.2	-	8	1550	c.1326T>A	c.(1324-1326)ttT>ttA	p.F442L	RNF216_ENST00000389902.3_Missense_Mutation_p.F499L	NM_207111.3|NM_207116.2	NP_996994.1|NP_996999.1	Q9NWF9	RN216_HUMAN	ring finger protein 216	442					apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus	ligase activity|protein binding|zinc ion binding		FBXL18/RNF216(2)	breast(3)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)|skin(1)|urinary_tract(4)	33		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		TACCTTGTTCAAACTTGAAAT	0.423000													12	246					0	0	0.001368	0	0
GLB1	2720	broad.mit.edu	37	3	33038605	33038605	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:33038605G>A	ENST00000307363.5	-	16	2110	c.1966C>T	c.(1966-1968)Cct>Tct	p.P656S	GLB1_ENST00000399402.3_Missense_Mutation_p.P626S|GLB1_ENST00000307377.8_Missense_Mutation_p.P525S|GLB1_ENST00000445488.2_Missense_Mutation_p.P704S	NM_000404.2	NP_000395.2	P16278	BGAL_HUMAN	galactosidase, beta 1	656					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(6)|lung(3)|ovary(1)|skin(1)|urinary_tract(1)	21		Melanoma(143;0.104)				TTTTCAACAGGTTTGGAGGGA	0.493000													31	67					0	0	0.002096	0	0
DSC3	1825	broad.mit.edu	37	18	28598187	28598187	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:28598187C>T	ENST00000434452.1	-	9	1267	c.1113G>A	c.(1111-1113)gtG>gtA	p.V371V	DSC3_ENST00000360428.4_Silent_p.V371V	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	371	Cadherin 3.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			GTAAGATTTCCACATTGAATG	0.274000													12	29					0	0	0.000978	0	0
PADI4	23569	broad.mit.edu	37	1	17657546	17657546	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:17657546A>C	ENST00000375448.4	+	2	201	c.175A>C	c.(175-177)Aag>Cag	p.K59Q	AC004824.2_ENST00000602074.1_Intron|PADI4_ENST00000375453.1_Missense_Mutation_p.K59Q	NM_012387.2	NP_036519.2	Q9UM07	PADI4_HUMAN	peptidyl arginine deiminase, type IV	59					chromatin modification|peptidyl-citrulline biosynthetic process from peptidyl-arginine|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			autonomic_ganglia(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(2)|urinary_tract(3)	26		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000338)|Lung NSC(340;0.00042)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00537)|BRCA - Breast invasive adenocarcinoma(304;8.54e-06)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(64;0.000223)|KIRC - Kidney renal clear cell carcinoma(64;0.00313)|STAD - Stomach adenocarcinoma(196;0.00707)|READ - Rectum adenocarcinoma(331;0.0689)|Lung(427;0.199)	L-Citrulline(DB00155)	CCCTCCAGCCAAGAAGAAATC	0.602000													18	36					0	0	0.007413	0	0
SSPO	23145	broad.mit.edu	37	7	149490420	149490420	+	RNA	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:149490420G>A	ENST00000378016.2	+	0	5896							A2VEC9	SSPO_HUMAN	SCO-spondin						cell adhesion	extracellular space	peptidase inhibitor activity					Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			GCCCTGTGAGGGGTGTGAGCA	0.647000													8	22					0	0	0.000673	0	0
PSAT1	29968	broad.mit.edu	37	9	80921351	80921351	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:80921351G>A	ENST00000376588.3	+	5	587	c.519G>A	c.(517-519)ctG>ctA	p.L173L	PSAT1_ENST00000347159.2_Silent_p.L173L	NM_058179.2	NP_478059.1	Q9Y617	SERC_HUMAN	phosphoserine aminotransferase 1	173					L-serine biosynthetic process|pyridoxine biosynthetic process		O-phospho-L-serine:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|urinary_tract(1)	20					L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)	GAGCAGTACTGGTTTGTGACA	0.502000													256	36					0	0	0.003610	0	0
RAB5B	5869	broad.mit.edu	37	12	56380879	56380879	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:56380879C>T	ENST00000360299.5	+	2	356	c.135C>T	c.(133-135)ttC>ttT	p.F45F	RAB5B_ENST00000448789.2_Silent_p.F45F|RAB5B_ENST00000553116.1_Silent_p.F45F	NM_002868.3	NP_002859.1	P61020	RAB5B_HUMAN	RAB5B, member RAS oncogene family	45					protein transport|small GTPase mediated signal transduction	early endosome membrane|melanosome|membrane fraction|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity			endometrium(1)|large_intestine(1)|liver(2)|lung(4)|upper_aerodigestive_tract(1)	9			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.235)			AAGGGCAGTTCCATGAGTACC	0.458000													25	48					0	0	0.002445	0	0
PARP8	79668	broad.mit.edu	37	5	50118184	50118184	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:50118184C>T	ENST00000281631.5	+	17	1968	c.1810C>T	c.(1810-1812)Cga>Tga	p.R604*	PARP8_ENST00000511363.2_3'UTR|PARP8_ENST00000505554.1_Nonsense_Mutation_p.R583*|PARP8_ENST00000514342.2_Nonsense_Mutation_p.R315*|PARP8_ENST00000505697.2_Nonsense_Mutation_p.R604*|PARP8_ENST00000514067.2_Nonsense_Mutation_p.R562*|PARP8_ENST00000503750.2_Nonsense_Mutation_p.R562*	NM_001178056.1|NM_024615.3	NP_001171527.1|NP_078891.2	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	604						intracellular	NAD+ ADP-ribosyltransferase activity			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(10)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Lung NSC(810;0.0305)|Breast(144;0.222)				GAACTATGATCGAGTAATGAA	0.303000													48	112					0	0	0.003610	0	0
COL25A1	84570	broad.mit.edu	37	4	109765723	109765723	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:109765723G>A	ENST00000399132.1	-	30	2111	c.1581C>T	c.(1579-1581)atC>atT	p.I527I	COL25A1_ENST00000399127.1_Silent_p.I500I|COL25A1_ENST00000399126.1_Silent_p.I527I	NM_198721.2	NP_942014.1	Q9BXS0	COPA1_HUMAN	collagen, type XXV, alpha 1	527						collagen|extracellular space	beta-amyloid binding|heparin binding			NS(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(19)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	49		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000173)		gtgggcctATGATCTGTATGT	0.438000													26	35					0	0	0.006320	0	0
DNAH1	25981	broad.mit.edu	37	3	52387454	52387454	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:52387454C>T	ENST00000420323.2	+	20	3546	c.3285C>T	c.(3283-3285)atC>atT	p.I1095I		NM_015512.4	NP_056327.4	Q9P2D7	DYH1_HUMAN	dynein, axonemal, heavy chain 1	1095	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement|response to mechanical stimulus	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			cervix(2)|endometrium(18)|kidney(6)|large_intestine(3)|lung(31)|prostate(1)|urinary_tract(1)	62				BRCA - Breast invasive adenocarcinoma(193;2.02e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000207)|Kidney(197;0.0022)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		AACCATACATCCCACTGATCC	0.602000													26	62					0	0	0.006320	0	0
TOX2	84969	broad.mit.edu	37	20	42682973	42682973	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:42682973G>A	ENST00000358131.5	+	5	921	c.713G>A	c.(712-714)gGa>gAa	p.G238E	TOX2_ENST00000423191.1_Missense_Mutation_p.G187E|TOX2_ENST00000372999.1_Missense_Mutation_p.G187E|TOX2_ENST00000341197.3_Missense_Mutation_p.G229E|TOX2_ENST00000435864.2_Missense_Mutation_p.G107E	NM_001098798.1	NP_001092268.1	Q96NM4	TOX2_HUMAN	TOX high mobility group box family member 2	238					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)	26		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.00189)			GCCGACCCAGGAAAAAAGGCC	0.537000													6	12					0	0	0.001168	0	0
OCIAD2	132299	broad.mit.edu	37	4	48894788	48894788	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:48894788C>T	ENST00000508632.1	-	6	616		c.e6+1		OCIAD2_ENST00000273860.4_Intron|OCIAD2_ENST00000508069.2_Splice_Site	NM_001014446.1	NP_001014446.1	Q56VL3	OCAD2_HUMAN	OCIA domain containing 2							endosome				kidney(1)|lung(3)|skin(1)|urinary_tract(1)	6						AGATTACAAACCTGTTATGCT	0.328000													50	297					0	0	0.003610	0	0
DCDC1	341019	broad.mit.edu	37	11	30925117	30925117	+	Silent	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:30925117A>G	ENST00000597505.1	-	30	4421	c.4422T>C	c.(4420-4422)gaT>gaC	p.D1474D	DCDC1_ENST00000406071.2_Silent_p.D209D|DCDC1_ENST00000339794.5_Silent_p.D553D			P59894	DCDC1_HUMAN	doublecortin domain containing 1	0					intracellular signal transduction					central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(17)|pancreas(2)|prostate(1)|skin(1)|stomach(1)	31	Lung SC(675;0.225)					GAAAGGATTCATCTAGAGCCC	0.433000													6	9					0	0	0.001168	0	0
ITIH6	347365	broad.mit.edu	37	X	54783453	54783453	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:54783453G>A	ENST00000218436.6	-	8	3083	c.3054C>T	c.(3052-3054)ttC>ttT	p.F1018F		NM_198510.2	NP_940912.1	Q6UXX5	ITH5L_HUMAN	inter-alpha-trypsin inhibitor heavy chain family, member 6	1018					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										AGGACTCCACGAACTTGGATT	0.522000													14	0					0	0	0.004990	0	0
SNAPC4	6621	broad.mit.edu	37	9	139273392	139273392	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:139273392G>A	ENST00000298532.2	-	21	3255	c.2887C>T	c.(2887-2889)Cct>Tct	p.P963S		NM_003086.2	NP_003077.2	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex, polypeptide 4, 190kDa	963	Pro-rich.				snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity			biliary_tract(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|prostate(3)|skin(2)|urinary_tract(1)	33		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		GAAGTGCCAGGTTTGGCTGCC	0.667000													13	12					0	0	0.001368	0	0
UGT1A5	54579	broad.mit.edu	37	2	234622455	234622455	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:234622455T>C	ENST00000373414.3	+	1	818	c.818T>C	c.(817-819)aTg>aCg	p.M273T	UGT1A6_ENST00000480628.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A10_ENST00000344644.5_Intron	NM_019078.1	NP_061951.1														cervix(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	22		Breast(86;0.000765)|all_lung(227;0.00267)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0457)|Lung SC(224;0.128)		Epithelial(121;4.51e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000523)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.00645)		ATGCCCAACATGGTCTTCATT	0.502000													10	34					0	0	0.002780	0	0
TANC2	26115	broad.mit.edu	37	17	61499273	61499273	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:61499273C>T	ENST00000424789.2	+	25	5934	c.5930C>T	c.(5929-5931)tCc>tTc	p.S1977F	RP11-269G24.3_ENST00000583552.1_RNA|TANC2_ENST00000389520.4_Missense_Mutation_p.S1987F	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	1977							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						GGGCAGACATCCCCTATCAAA	0.502000													19	68					0	0	0.007413	0	0
TRMT44	152992	broad.mit.edu	37	4	8472850	8472850	+	Missense_Mutation	SNP	C	C	T	rs146322919	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:8472850C>T	ENST00000389737.4	+	10	1967	c.1967C>T	c.(1966-1968)aCg>aTg	p.T656M		NM_152544.2	NP_689757.2			tRNA methyltransferase 44 homolog (S. cerevisiae)																		GAGCTGGACACGGAGACCCTG	0.567000													34	217					0	0	0.003755	0	0
PLA1A	51365	broad.mit.edu	37	3	119328383	119328383	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:119328383G>A	ENST00000273371.4	+	4	594	c.522G>A	c.(520-522)atG>atA	p.M174I	PLA1A_ENST00000495992.1_Missense_Mutation_p.M158I|PLA1A_ENST00000488919.1_Start_Codon_SNP_p.M1I|PLA1A_ENST00000494440.1_Missense_Mutation_p.M158I	NM_015900.3	NP_056984.1	Q53H76	PLA1A_HUMAN	phospholipase A1 member A	174					lipid catabolic process|phosphatidylserine metabolic process	extracellular region	phospholipase A1 activity			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TTGGGGGCATGGTGGGACAGC	0.562000													31	92					0	0	0.004289	0	0
CUX2	23316	broad.mit.edu	37	12	111785550	111785550	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:111785550C>T	ENST00000261726.6	+	22	4036	c.3882C>T	c.(3880-3882)gcC>gcT	p.A1294A		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	1294						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						AGGACAAGGCCCAAGTGAGGA	0.607000													5	28					0	0	0.001168	0	0
PMS2	5395	broad.mit.edu	37	7	6027010	6027010	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:6027010G>A	ENST00000265849.7	-	11	1491	c.1386C>T	c.(1384-1386)atC>atT	p.I462I	PMS2_ENST00000406569.3_Silent_p.I462I|PMS2_ENST00000469652.1_Intron|PMS2_ENST00000441476.2_Silent_p.I356I|PMS2_ENST00000382321.4_Intron	NM_000535.5	NP_000526.1	P54278	PMS2_HUMAN	PMS2 postmeiotic segregation increased 2 (S. cerevisiae)	462					mismatch repair|reciprocal meiotic recombination|somatic hypermutation of immunoglobulin genes	MutLalpha complex	ATP binding|ATPase activity|endonuclease activity|protein binding|single base insertion or deletion binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(6)|kidney(2)|large_intestine(11)|lung(13)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.101)|OV - Ovarian serous cystadenocarcinoma(56;4.39e-15)		CTTTGTCAGAGATGGCACCTG	0.557000			"""Mis, N, F"""			"""colorectal, endometrial, ovarian, medulloblastoma, glioma"""		Direct reversal of damage;Mismatch excision repair (MMR)	Turcot syndrome;Lynch syndrome;Constitutional Mismatch Repair Deficiency Syndrome				21	341					0	0	0.002780	0	0
TRIM6	117854	broad.mit.edu	37	11	5631789	5631789	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:5631789G>A	ENST00000380097.3	+	7	1225	c.983G>A	c.(982-984)tGg>tAg	p.W328*	TRIM6_ENST00000380107.1_Nonsense_Mutation_p.W274*|TRIM6_ENST00000515022.1_Nonsense_Mutation_p.W125*|HBG2_ENST00000380259.2_Intron|TRIM6_ENST00000506134.1_Nonsense_Mutation_p.W125*|AC015691.13_ENST00000394793.2_RNA|TRIM6_ENST00000507320.1_Nonsense_Mutation_p.W125*|TRIM6_ENST00000481603.1_3'UTR|TRIM6_ENST00000445329.1_Nonsense_Mutation_p.W125*|TRIM6-TRIM34_ENST00000354852.5_Nonsense_Mutation_p.W328*|TRIM6_ENST00000278302.5_Nonsense_Mutation_p.W300*	NM_001003818.2|NM_001198644.1|NM_001198645.1	NP_001003818.1|NP_001185573.1|NP_001185574.1			tripartite motif containing 6											breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|prostate(2)|stomach(1)	22		Lung NSC(207;2.23e-07)|all_lung(207;1.81e-06)|Medulloblastoma(188;0.00225)|Breast(177;0.0101)|all_neural(188;0.0212)		Epithelial(150;1.12e-45)|BRCA - Breast invasive adenocarcinoma(625;0.00101)|LUSC - Lung squamous cell carcinoma(625;0.192)		CAAAGCTACTGGGGTAAGTAG	0.463000													28	32					0	0	0.004289	0	0
DUOX2	50506	broad.mit.edu	37	15	45394107	45394107	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:45394107C>T	ENST00000389039.6	-	21	3120	c.2735G>A	c.(2734-2736)gGa>gAa	p.G912E	DUOX2_ENST00000603300.1_Missense_Mutation_p.G912E			Q9NRD8	DUOX2_HUMAN	dual oxidase 2	912	EF-hand 3.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(7)|urinary_tract(1)	63		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		GTCCTGGAATCCCGACTCCCG	0.572000													15	21					0	0	0.004990	0	0
PTPRK	5796	broad.mit.edu	37	6	128306886	128306886	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:128306886G>A	ENST00000368227.3	-	23	3648	c.3282C>T	c.(3280-3282)ggC>ggT	p.G1094G	PTPRK_ENST00000368207.3_Silent_p.G1109G|PTPRK_ENST00000368210.3_Silent_p.G1095G|PTPRK_ENST00000368226.4_Silent_p.G1077G|PTPRK_ENST00000532331.1_Silent_p.G1099G|PTPRK_ENST00000368215.3_Silent_p.G1076G|PTPRK_ENST00000368213.5_Silent_p.G1083G			Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1076	Tyrosine-protein phosphatase 1.				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity		PTPRK/RSPO3(10)	autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(14)|lung(24)|ovary(3)|pancreas(1)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	72				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		CAACGATGGGGCCAGCACTGG	0.483000													17	24					0	0	0.004007	0	0
OC90	729330	broad.mit.edu	37	8	133048632	133048632	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:133048632G>C	ENST00000262283.5	-	13	1400	c.1301C>G	c.(1300-1302)aCt>aGt	p.T434S	OC90_ENST00000603859.1_Intron|OC90_ENST00000443356.2_Missense_Mutation_p.T238S|OC90_ENST00000254627.3_Intron			Q02509	OC90_HUMAN	otoconin 90	238	Phospholipase A2-like 3.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			CTTGGAGAGAGTGATCAGTCT	0.443000													15	142					0	0	0.007413	0	0
DGAT2	84649	broad.mit.edu	37	11	75501774	75501774	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:75501774C>T	ENST00000228027.7	+	4	687	c.427C>T	c.(427-429)Cag>Tag	p.Q143*	DGAT2_ENST00000376262.3_Nonsense_Mutation_p.Q100*	NM_032564.4	NP_115953.2	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	143					glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity			endometrium(3)|large_intestine(5)|lung(5)|prostate(2)|skin(2)	17	Ovarian(111;0.103)					CTTTCCCATCCAGGTAAAGTG	0.517000													18	66					0	0	0.001523	0	0
RNF122	79845	broad.mit.edu	37	8	33406360	33406360	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:33406360G>A	ENST00000256257.1	-	6	780	c.379C>T	c.(379-381)Cgc>Tgc	p.R127C		NM_024787.2	NP_079063.2	Q9H9V4	RN122_HUMAN	ring finger protein 122	127						endoplasmic reticulum|Golgi apparatus|integral to membrane	zinc ion binding	p.R127C(1)		endometrium(2)|large_intestine(3)|ovary(1)|upper_aerodigestive_tract(1)	7				KIRC - Kidney renal clear cell carcinoma(67;0.0966)|Kidney(114;0.116)		CAGACACAGCGAACTTCCAGC	0.498000													60	120					0	0	0.003610	0	0
NLRP11	204801	broad.mit.edu	37	19	56321526	56321526	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:56321526G>A	ENST00000443188.1	-	5	1160	c.450C>T	c.(448-450)ttC>ttT	p.F150F	NLRP11_ENST00000592953.1_Silent_p.F51F|NLRP11_ENST00000360133.3_Silent_p.F150F|NLRP11_ENST00000589824.2_Silent_p.F150F|NLRP11_ENST00000589093.1_Silent_p.F150F	NM_145007.3	NP_659444.2	P59045	NAL11_HUMAN	NLR family, pyrin domain containing 11	150	NACHT.						ATP binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	66		Colorectal(82;0.0002)		GBM - Glioblastoma multiforme(193;0.0325)		CTCCCATCAGGAACACATTGA	0.393000													17	22					0	0	0.006122	0	0
KDR	3791	broad.mit.edu	37	4	55984928	55984928	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:55984928C>T	ENST00000263923.4	-	3	496	c.201G>A	c.(199-201)caG>caA	p.Q67Q		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	67	Ig-like C2-type 1.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	CACTGCCACTCTGATTATTGG	0.468000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			19	137					0	0	0.002780	0	0
C3orf20	84077	broad.mit.edu	37	3	14744762	14744762	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:14744762C>T	ENST00000253697.3	+	6	1323	c.871C>T	c.(871-873)Cgc>Tgc	p.R291C	C3orf20_ENST00000412910.1_Missense_Mutation_p.R169C|C3orf20_ENST00000435614.1_Missense_Mutation_p.R169C	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	291						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						GGAGTTGTGTCGCCACATGTG	0.627000													35	67					0	0	0.004878	0	0
ESRP1	54845	broad.mit.edu	37	8	95680371	95680371	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:95680371C>T	ENST00000433389.2	+	10	1316	c.1126C>T	c.(1126-1128)Ctc>Ttc	p.L376F	ESRP1_ENST00000454170.2_Missense_Mutation_p.L376F|ESRP1_ENST00000423620.2_Missense_Mutation_p.L376F|ESRP1_ENST00000358397.5_Missense_Mutation_p.L376F	NM_001034915.2|NM_017697.3	NP_001030087.2|NP_060167.2	Q6NXG1	ESRP1_HUMAN	epithelial splicing regulatory protein 1	376	RRM 2.				mRNA processing|regulation of RNA splicing|RNA splicing	nucleus|plasma membrane	mRNA binding|nucleotide binding		ESRP1/RAF1(4)	NS(1)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(6)|prostate(1)|urinary_tract(2)	20						CGCTTTTGTCCTCTTTGCCTG	0.488000													179	684					0	0	0.003610	0	0
IGDCC4	57722	broad.mit.edu	37	15	65676382	65676382	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:65676382C>T	ENST00000352385.2	-	20	3927	c.3718G>A	c.(3718-3720)Ggc>Agc	p.G1240S	IGDCC4_ENST00000558048.1_5'UTR	NM_020962.1	NP_066013.1	Q8TDY8	IGDC4_HUMAN	immunoglobulin superfamily, DCC subclass, member 4	1240						integral to membrane|plasma membrane				NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(24)|ovary(1)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	44						CTGGGCAGGCCTGGGCTGGCT	0.622000													10	24					0	0	0.002450	0	0
CYP11B2	1585	broad.mit.edu	37	8	143999086	143999086	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:143999086C>T	ENST00000323110.2	-	1	173	c.171G>A	c.(169-171)agG>agA	p.R57R		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	57					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	AACCCTGCTCCCTCCAGATCT	0.632000									Familial Hyperaldosteronism type I				41	79					0	0	0.006230	0	0
C19orf44	84167	broad.mit.edu	37	19	16613942	16613942	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:16613942A>C	ENST00000221671.3	+	3	982	c.826A>C	c.(826-828)Aca>Cca	p.T276P	CTD-3222D19.2_ENST00000409035.1_Intron|C19orf44_ENST00000594035.1_Missense_Mutation_p.T276P	NM_032207.2	NP_115583.1	Q9H6X5	CS044_HUMAN	chromosome 19 open reading frame 44	276										endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|skin(1)|stomach(1)|urinary_tract(2)	16						GCCTTCTCAGACATCACACCT	0.502000													26	30					0	0	0.001512	0	0
LRP1B	53353	broad.mit.edu	37	2	141607881	141607881	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:141607881G>A	ENST00000389484.3	-	29	5700	c.4729C>T	c.(4729-4731)Ctt>Ttt	p.L1577F		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1577					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CTTGCATAAAGAAGAAATTTT	0.303000										TSP Lung(27;0.18)			11	10					0	0	0.000978	0	0
COL12A1	1303	broad.mit.edu	37	6	75858113	75858113	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:75858113C>T	ENST00000322507.8	-	22	4557	c.4248G>A	c.(4246-4248)aaG>aaA	p.K1416K	COL12A1_ENST00000483888.2_Silent_p.K1416K|COL12A1_ENST00000345356.6_Silent_p.K252K|COL12A1_ENST00000416123.2_Silent_p.K1416K	NM_004370.5	NP_004361.3	Q99715	COCA1_HUMAN	collagen, type XII, alpha 1	1416	Fibronectin type-III 9.				cell adhesion|collagen fibril organization|skeletal system development	collagen type XII|extracellular space	extracellular matrix structural constituent conferring tensile strength			breast(7)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(5)|kidney(5)|large_intestine(44)|liver(1)|lung(77)|ovary(7)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(4)|urinary_tract(2)	169						AGTATTCCACCTTATATCGAT	0.433000													18	20					0	0	0.004990	0	0
TTLL8	164714	broad.mit.edu	37	22	50470225	50470225	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:50470225G>A	ENST00000266182.6	-	11	1596	c.1597C>T	c.(1597-1599)Ccg>Tcg	p.P533S	TTLL8_ENST00000440475.1_Missense_Mutation_p.P513S					tubulin tyrosine ligase-like family, member 8											NS(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|ovary(4)	12		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		GGCGTGGACGGGTGCATGGTG	0.622000													10	79					0	0	0.000673	0	0
CCR3	1232	broad.mit.edu	37	3	46307396	46307396	+	Silent	SNP	C	C	T	rs76939117		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:46307396C>T	ENST00000357422.2	+	4	1290	c.747C>T	c.(745-747)ttC>ttT	p.F249F	CCR3_ENST00000545097.1_Silent_p.F270F|CCR3_ENST00000395942.2_Silent_p.F249F|CCR3_ENST00000395940.2_Silent_p.F249F|CCR3_ENST00000541018.1_Silent_p.F249F			P51677	CCR3_HUMAN	chemokine (C-C motif) receptor 3	249					cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(3)|urinary_tract(1)	18				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		CGGTGTTTTTCATTTTCTGGA	0.458000													17	60					0	0	0.001216	0	0
LY75	4065	broad.mit.edu	37	2	160667116	160667116	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:160667116G>A	ENST00000263636.4	-	32	4647	c.4620C>T	c.(4618-4620)atC>atT	p.I1540I	LY75_ENST00000553424.1_Silent_p.I1540I|LY75_ENST00000554112.1_Silent_p.I1540I|LY75-CD302_ENST00000504764.1_Silent_p.I1540I|LY75-CD302_ENST00000505052.1_Silent_p.I1540I	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		CCTTGTACTGGATCCACCGTG	0.383000													79	101					0	0	0.003610	0	0
LILRB1	10859	broad.mit.edu	37	19	55144102	55144102	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55144102C>T	ENST00000396331.1	+	7	1206	c.849C>T	c.(847-849)acC>acT	p.T283T	LILRB1_ENST00000418536.2_Silent_p.T283T|LILRB1_ENST00000396317.1_Silent_p.T283T|LILRB1_ENST00000396321.2_Silent_p.T283T|LILRB1_ENST00000434867.2_Silent_p.T283T|LILRB1_ENST00000324602.7_Silent_p.T283T|LILRB1_ENST00000427581.2_Silent_p.T319T|LILRB1_ENST00000396332.4_Silent_p.T283T|LILRB1_ENST00000448689.1_Silent_p.T283T|LILRB1_ENST00000396315.1_Silent_p.T283T|LILRB1_ENST00000396327.3_Silent_p.T283T	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	283	Ig-like C2-type 3.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CCAACTTCACCCTGGGCCCTG	0.632000										HNSCC(37;0.09)			21	56					0	0	0.001523	0	0
MAGEA1	4100	broad.mit.edu	37	X	152482458	152482458	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:152482458C>T	ENST00000356661.5	-	3	771	c.553G>A	c.(553-555)Gat>Aat	p.D185N		NM_004988.4	NP_004979.3	P43355	MAGA1_HUMAN	melanoma antigen family A, 1 (directs expression of antigen MZ2-E)	185	MAGE.					cytoplasm|plasma membrane				breast(1)|central_nervous_system(7)|kidney(2)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					ATCTGATTATCACCCAGCAGG	0.547000													42	6					0	0	0.003610	0	0
SCFD1	23256	broad.mit.edu	37	14	31144256	31144256	+	Silent	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:31144256T>G	ENST00000458591.2	+	14	1454	c.1227T>G	c.(1225-1227)gtT>gtG	p.V409V	SCFD1_ENST00000541123.1_Silent_p.V224V|SCFD1_ENST00000544052.2_Silent_p.V342V|SCFD1_ENST00000396629.2_Silent_p.V317V|SCFD1_ENST00000421551.3_Silent_p.V350V	NM_016106.3	NP_057190.2	Q8WVM8	SCFD1_HUMAN	sec1 family domain containing 1	409					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)	13	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		CCACTGCTGTTTTAGAACATA	0.303000													25	27					0	0	0.001512	0	0
BCL2L1	598	broad.mit.edu	37	20	30309749	30309749	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:30309749C>T	ENST00000307677.4	-	2	683	c.273G>A	c.(271-273)agG>agA	p.R91R	BCL2L1_ENST00000420653.1_Silent_p.R91R|BCL2L1_ENST00000376055.4_Silent_p.R91R|BCL2L1_ENST00000376062.2_Silent_p.R91R	NM_138578.1	NP_612815.1	Q07817	B2CL1_HUMAN	BCL2-like 1	91					induction of apoptosis by intracellular signals|negative regulation of establishment of protein localization in plasma membrane|negative regulation of survival gene product expression|regulation of mitochondrial membrane permeability|regulation of mitochondrial membrane potential|release of cytochrome c from mitochondria|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nuclear membrane	BH3 domain binding|identical protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|lung(4)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	all_cancers(5;3.47e-06)|all_epithelial(3;1.83e-06)|Lung NSC(7;2.08e-06)|all_lung(7;3.63e-06)|all_hematologic(12;0.158)|Ovarian(7;0.198)		Epithelial(4;2.97e-06)|all cancers(5;3.21e-05)|OV - Ovarian serous cystadenocarcinoma(3;0.00052)|Colorectal(19;0.0055)|COAD - Colon adenocarcinoma(19;0.0264)			CGCCTGCCTCCCTCAGCGCTT	0.607000													18	66					0	0	0.003330	0	0
LRFN2	57497	broad.mit.edu	37	6	40400350	40400350	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:40400350G>A	ENST00000338305.6	-	2	1045	c.503C>T	c.(502-504)tCc>tTc	p.S168F		NM_020737.1	NP_065788.1	Q9ULH4	LRFN2_HUMAN	leucine rich repeat and fibronectin type III domain containing 2	168						cell junction|integral to membrane|postsynaptic membrane				breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	58	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCGTCGCACGGAGTCCCACGG	0.607000													28	112					0	0	0.006320	0	0
SLC27A5	10998	broad.mit.edu	37	19	59010861	59010861	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:59010861G>A	ENST00000263093.2	-	7	1774	c.1665C>T	c.(1663-1665)ttC>ttT	p.F555F	SLC27A5_ENST00000601355.1_Silent_p.F471F	NM_012254.2	NP_036386.1	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid transporter), member 5	555					bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		CCTCGGACCGGAAGGTGTCCC	0.657000													12	66					0	0	0.001855	0	0
HTT	3064	broad.mit.edu	37	4	3237335	3237335	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:3237335C>T	ENST00000355072.5	+	63	8760	c.8615C>T	c.(8614-8616)tCc>tTc	p.S2872F		NM_002111.6	NP_002102.4	P42858	HD_HUMAN	huntingtin	2872					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			breast(1)|cervix(2)|endometrium(14)|kidney(5)|large_intestine(23)|lung(28)|ovary(4)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	87		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		TCCACCCCCTCCATCATTTAC	0.577000													6	66					0	0	0.004482	0	0
GPR61	83873	broad.mit.edu	37	1	110085663	110085663	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:110085663C>T	ENST00000527748.1	+	2	702	c.19C>T	c.(19-21)Ccc>Tcc	p.P7S	RP5-1160K1.8_ENST00000526411.1_RNA	NM_031936.4	NP_114142.3	Q9BZJ8	GPR61_HUMAN	G protein-coupled receptor 61	7						integral to membrane|plasma membrane	G-protein coupled receptor activity	p.P7S(1)		breast(1)|central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(4)|lung(9)|stomach(1)|urinary_tract(1)	23		all_epithelial(167;2.83e-05)|all_lung(203;0.00016)|Lung NSC(277;0.000318)|Breast(1374;0.244)		Lung(183;0.0426)|Colorectal(144;0.11)|Epithelial(280;0.128)|all cancers(265;0.132)|LUSC - Lung squamous cell carcinoma(189;0.228)		CTCACCCATCCCCCAGTCATC	0.647000													11	15					0	0	0.000978	0	0
MYO6	4646	broad.mit.edu	37	6	76551093	76551093	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:76551093C>T	ENST00000369981.3	+	9	1093	c.814C>T	c.(814-816)Cgg>Tgg	p.R272W	MYO6_ENST00000369985.4_Missense_Mutation_p.R272W|MYO6_ENST00000369977.3_Missense_Mutation_p.R272W|MYO6_ENST00000369975.1_Missense_Mutation_p.R272W			Q9UM54	MYO6_HUMAN	myosin VI	272	Myosin head-like.				actin filament-based movement|DNA damage response, signal transduction by p53 class mediator|endocytosis|intracellular protein transport|positive regulation of transcription from RNA polymerase II promoter|regulation of secretion|sensory perception of sound|synaptic transmission	cell cortex|clathrin coated vesicle membrane|coated pit|cytosol|DNA-directed RNA polymerase II, holoenzyme|filamentous actin|Golgi apparatus|nuclear membrane|perinuclear region of cytoplasm|ruffle membrane|unconventional myosin complex	actin filament binding|ADP binding|ATP binding|calmodulin binding|minus-end directed microfilament motor activity|protein binding			breast(2)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(16)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	58		all_hematologic(105;0.189)		BRCA - Breast invasive adenocarcinoma(397;0.223)		AGATAATTTTCGGGTAGGTCA	0.413000													13	21					0	0	0.001368	0	0
TOMM70A	9868	broad.mit.edu	37	3	100100601	100100601	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:100100601C>T	ENST00000284320.5	-	5	1190	c.742G>A	c.(742-744)Gaa>Aaa	p.E248K		NM_014820.4	NP_055635.3	O94826	TOM70_HUMAN	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)	248					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane translocase complex	protein binding|protein transmembrane transporter activity			endometrium(11)|large_intestine(5)|lung(10)|ovary(2)|skin(2)|upper_aerodigestive_tract(2)	32						ATCAGAGGTTCACGATTCTGA	0.373000													12	32					0	0	0.001368	0	0
GPR174	84636	broad.mit.edu	37	X	78427122	78427122	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:78427122G>A	ENST00000276077.1	+	1	654	c.618G>A	c.(616-618)tgG>tgA	p.W206*		NM_032553.1	NP_115942.1	Q9BXC1	GP174_HUMAN	G protein-coupled receptor 174	206						integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(1)|lung(19)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	38						ATTGTACCTGGAAGACGGTTT	0.453000										HNSCC(63;0.18)			29	2					0	0	0.005443	0	0
HTR3D	200909	broad.mit.edu	37	3	183756374	183756374	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:183756374G>A	ENST00000382489.3	+	7	1097	c.1097G>A	c.(1096-1098)gGa>gAa	p.G366E	HTR3D_ENST00000428798.2_Missense_Mutation_p.G316E|HTR3D_ENST00000334128.2_Missense_Mutation_p.G191E|HTR3D_ENST00000453435.1_Missense_Mutation_p.G145E	NM_001163646.1	NP_001157118.1	Q70Z44	5HT3D_HUMAN	5-hydroxytryptamine (serotonin) receptor 3D, ionotropic	366						integral to membrane|plasma membrane	extracellular ligand-gated ion channel activity|receptor activity			large_intestine(3)|lung(3)|prostate(1)|skin(1)|stomach(2)	10	all_cancers(143;2.33e-10)|Ovarian(172;0.0303)		Epithelial(37;6.23e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CCCCAGAAGGGAAATAAGGGC	0.657000													6	18					0	0	0.001984	0	0
GYG1	2992	broad.mit.edu	37	3	148744726	148744726	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:148744726C>G	ENST00000484197.1	+	6	871	c.788C>G	c.(787-789)aCt>aGt	p.T263S	GYG1_ENST00000479119.1_3'UTR|GYG1_ENST00000296048.6_3'UTR|GYG1_ENST00000345003.4_3'UTR	NM_001184721.1	NP_001171650.1	P46976	GLYG_HUMAN	glycogenin 1	0					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	glycogenin glucosyltransferase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|lung(3)|ovary(1)	8			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			AGTAGAAACACTGCATTTTTC	0.428000													13	69					0	0	0.004007	0	0
OPRK1	4986	broad.mit.edu	37	8	54142080	54142080	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:54142080G>A	ENST00000265572.3	-	4	1217	c.920C>T	c.(919-921)gCt>gTt	p.A307V	RP11-162D9.3_ENST00000524425.1_RNA|OPRK1_ENST00000524278.1_Missense_Mutation_p.A218V|OPRK1_ENST00000520287.1_Missense_Mutation_p.A307V	NM_000912.3	NP_000903.2	P41145	OPRK_HUMAN	opioid receptor, kappa 1	307					behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			NS(2)|breast(3)|endometrium(3)|kidney(12)|large_intestine(7)|lung(8)|ovary(1)|prostate(1)|skin(5)|urinary_tract(1)	43		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	GGAGAGAGCAGCTGTGCTGTG	0.527000													28	42					0	0	0.006320	0	0
TCERG1L	256536	broad.mit.edu	37	10	133107460	133107460	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:133107460G>A	ENST00000368642.4	-	2	530	c.445C>T	c.(445-447)Cct>Tct	p.P149S		NM_174937.3	NP_777597.2	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	149	WW 1.									cervix(1)|endometrium(2)|kidney(1)|large_intestine(10)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	31		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		TTCCCAATAGGGGTTGCAAGA	0.478000													15	22					0	0	0.004007	0	0
PCDH9	5101	broad.mit.edu	37	13	66878807	66878807	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:66878807G>T	ENST00000544246.1	-	5	4385	c.3694C>A	c.(3694-3696)Cct>Act	p.P1232T	PCDH9_ENST00000456367.1_Missense_Mutation_p.P1198T|PCDH9_ENST00000328454.5_Missense_Mutation_p.P1198T|PCDH9-AS1_ENST00000430861.1_RNA|PCDH9_ENST00000377865.2_Missense_Mutation_p.P1232T	NM_203487.2	NP_982354.1	Q9HC56	PCDH9_HUMAN	protocadherin 9	1232					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(33)|lung(30)|ovary(5)|pancreas(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(3)	103		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TGCTCCTTAGGACTCTCAGTA	0.423000													17	31					5.3912e-06	9.15993e-06	0.006122	1	0
EFCAB6	64800	broad.mit.edu	37	22	44168800	44168800	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:44168800C>T	ENST00000262726.7	-	4	576	c.323G>A	c.(322-324)cGa>cAa	p.R108Q	EFCAB6_ENST00000396231.2_Intron|EFCAB6_ENST00000358439.4_Intron|EFCAB6_ENST00000356087.4_Intron	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	108					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				AAACTGTTCTCGTGTGAGCGG	0.463000													21	20					0	0	0.002299	0	0
CR1	1378	broad.mit.edu	37	1	207785184	207785184	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:207785184C>T	ENST00000367049.4	+	38	6458	c.6458C>T	c.(6457-6459)gCc>gTc	p.A2153V	CR1_ENST00000367052.1_Missense_Mutation_p.A1703V|CR1_ENST00000367053.1_Missense_Mutation_p.A1703V|CR1_ENST00000400960.2_Missense_Mutation_p.A1703V|CR1_ENST00000367051.1_Missense_Mutation_p.A1703V	NM_000651.4	NP_000642.3	P17927	CR1_HUMAN	complement component (3b/4b) receptor 1 (Knops blood group)	1703					complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						AGCCCTGAAGCCCCTAGATGT	0.532000													35	135					0	0	0.005524	0	0
CCDC170	80129	broad.mit.edu	37	6	151917610	151917610	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:151917610G>A	ENST00000367290.5	+	9	1697	c.1608G>A	c.(1606-1608)agG>agA	p.R536R	CCDC170_ENST00000239374.7_Silent_p.R536R			Q8IYT3	CF097_HUMAN	coiled-coil domain containing 170	536																	TTACCATCAGGAACTTGCAGA	0.557000													24	39					0	0	0.002780	0	0
KALRN	8997	broad.mit.edu	37	3	124418856	124418856	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:124418856G>A	ENST00000360013.3	+	56	8099	c.7972G>A	c.(7972-7974)Gag>Aag	p.E2658K	KALRN_ENST00000428018.2_Missense_Mutation_p.E929K|KALRN_ENST00000291478.4_Missense_Mutation_p.E961K	NM_001024660.3	NP_001019831.2	O60229	KALRN_HUMAN	kalirin, RhoGEF kinase	2657	Fibronectin type-III.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|vesicle-mediated transport	actin cytoskeleton|cytosol	ATP binding|GTPase activator activity|metal ion binding|protein binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(21)|lung(28)|ovary(4)|prostate(5)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	83						CGAGCCCTCGGAGTTTGTGCG	0.597000													38	98					0	0	0.002522	0	0
IL7R	3575	broad.mit.edu	37	5	35875626	35875626	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:35875626C>T	ENST00000343305.4	+	6	808	c.719C>T	c.(718-720)tCg>tTg	p.S240L	IL7R_ENST00000303115.3_Silent_p.I271I|IL7R_ENST00000506850.1_Missense_Mutation_p.S240L			P16871	IL7RA_HUMAN	interleukin 7 receptor	0					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			TTAAGCCTATCGTATGGCCCA	0.433000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						43	15					0	0	0.002222	0	0
TTBK1	84630	broad.mit.edu	37	6	43225664	43225664	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43225664C>T	ENST00000259750.4	+	10	1059	c.976C>T	c.(976-978)Ccg>Tcg	p.P326S	TTBK1_ENST00000304139.5_Missense_Mutation_p.P275S	NM_032538.1	NP_115927.1	Q5TCY1	TTBK1_HUMAN	tau tubulin kinase 1	326						cell junction|cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(10)|liver(1)|lung(21)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0125)|OV - Ovarian serous cystadenocarcinoma(102;0.0399)			CACCTCTACCCCGCCCCAGCA	0.617000													9	80					0	0	0.001855	0	0
CCKBR	887	broad.mit.edu	37	11	6292161	6292161	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:6292161G>A	ENST00000525462.1	+	4	942	c.939G>A	c.(937-939)tgG>tgA	p.W313*	CCKBR_ENST00000334619.2_Intron|CCKBR_ENST00000532715.1_Intron|CCKBR_ENST00000532396.1_Intron			P32239	GASR_HUMAN	cholecystokinin B receptor	266					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			NS(2)|breast(2)|endometrium(4)|kidney(13)|large_intestine(10)|lung(22)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	AGTTGAGCTGGGAGCGGAGGT	0.632000													4	5					0	0	0.000248	0	0
F9	2158	broad.mit.edu	37	X	138623299	138623299	+	Silent	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:138623299C>G	ENST00000218099.2	+	4	349	c.342C>G	c.(340-342)tcC>tcG	p.S114S	F9_ENST00000479617.1_3'UTR|F9_ENST00000394090.2_Intron	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	114	EGF-like 1; calcium-binding (Potential).				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	ACATTAATTCCTATGAATGTT	0.368000													22	4					0	0	0.002780	0	0
SPPL2A	84888	broad.mit.edu	37	15	51040393	51040393	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:51040393G>A	ENST00000261854.5	-	4	641	c.367C>T	c.(367-369)Ccc>Tcc	p.P123S	RP11-507J18.2_ENST00000558317.1_RNA	NM_032802.3	NP_116191.2	Q8TCT8	PSL2_HUMAN	signal peptide peptidase like 2A	123	PA.					integral to membrane	aspartic-type endopeptidase activity			endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	15				all cancers(107;0.000712)|GBM - Glioblastoma multiforme(94;0.00314)		TTACCTGAGGGAGGAAACTAA	0.249000													5	6					0	0	0.000602	0	0
MAS1L	116511	broad.mit.edu	37	6	29455262	29455262	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:29455262C>T	ENST00000377127.3	-	1	476	c.418G>A	c.(418-420)Gga>Aga	p.G140R		NM_052967.1	NP_443199.1	P35410	MAS1L_HUMAN	MAS1 oncogene-like	140						cytoplasm|integral to membrane|nucleus|plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(7)|ovary(7)|pancreas(1)|prostate(2)|skin(2)	28						AACACGACTCCATGATAAGTT	0.507000													21	59					0	0	0.001882	0	0
MRC2	9902	broad.mit.edu	37	17	60749032	60749032	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:60749032G>A	ENST00000303375.5	+	7	1542	c.1140G>A	c.(1138-1140)gtG>gtA	p.V380V		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	380					endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						ATGTGAAGGTGGAGTGCGAGC	0.642000													18	36					0	0	0.006122	0	0
ACSL6	23305	broad.mit.edu	37	5	131309017	131309017	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:131309017G>A	ENST00000379264.2	-	12	1253	c.1145C>T	c.(1144-1146)gCt>gTt	p.A382V	ACSL6_ENST00000543479.1_Missense_Mutation_p.A357V|ACSL6_ENST00000357096.1_Missense_Mutation_p.A282V|ACSL6_ENST00000544770.1_Missense_Mutation_p.A266V|ACSL6_ENST00000379249.3_Missense_Mutation_p.A357V|ACSL6_ENST00000379255.1_Missense_Mutation_p.A282V|ACSL6_ENST00000379246.1_Missense_Mutation_p.A368V|ACSL6_ENST00000296869.4_Missense_Mutation_p.A382V|ACSL6_ENST00000431707.1_Missense_Mutation_p.A337V|ACSL6_ENST00000379240.1_Missense_Mutation_p.A357V|ACSL6_ENST00000379244.1_Missense_Mutation_p.A357V|ACSL6_ENST00000379272.2_Missense_Mutation_p.A372V	NM_001009185.2	NP_001009185.1	Q9UKU0	ACSL6_HUMAN	acyl-CoA synthetase long-chain family member 6	357					fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane|plasma membrane	ATP binding|long-chain fatty acid-CoA ligase activity			NS(1)|breast(1)|endometrium(2)|kidney(4)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	35		all_cancers(142;0.107)|Breast(839;0.198)|Lung NSC(810;0.216)|all_lung(232;0.248)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GGGGCATAGAGCCTTCATGTC	0.557000													24	75					0	0	0.004656	0	0
ROM1	6094	broad.mit.edu	37	11	62382274	62382274	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:62382274G>A	ENST00000278833.3	+	3	1560	c.1019G>A	c.(1018-1020)gGa>gAa	p.G340E	ROM1_ENST00000534093.1_3'UTR	NM_000327.3	NP_000318.1	Q03395	ROM1_HUMAN	retinal outer segment membrane protein 1	340					cell adhesion|visual perception	integral to plasma membrane				central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(1)	8						GCCCCACCAGGAGAAGCACCT	0.572000													12	20					0	0	0.003163	0	0
CDK20	23552	broad.mit.edu	37	9	90586062	90586062	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:90586062C>T	ENST00000375883.3	-	3	684	c.378_splice	c.e3+1	p.R126_splice	CDK20_ENST00000605159.1_Splice_Site_p.R126_splice|CDK20_ENST00000325303.8_Splice_Site_p.R126_splice|CDK20_ENST00000336654.5_Splice_Site_p.R139_splice|CDK20_ENST00000375871.4_Splice_Site_p.R126_splice	NM_001170639.1|NM_012119.4|NM_178432.3	NP_001164110.1|NP_036251.2|NP_848519.1	Q8IZL9	CDK20_HUMAN	cyclin-dependent kinase 20	126	Protein kinase.				cell division|multicellular organismal development	cilium|mitochondrion|nucleus	ATP binding|cyclin-dependent protein kinase activity			skin(1)	1						TGAGACTGACCCGATGTACAA	0.577000													8	13					0	0	0.004482	0	0
GTF3C1	2975	broad.mit.edu	37	16	27481569	27481569	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:27481569G>A	ENST00000356183.4	-	31	4689	c.4674C>T	c.(4672-4674)gcC>gcT	p.A1558A	GTF3C1_ENST00000561623.1_Silent_p.A1558A	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1558						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						CCAGTGAAAAGGCCACCATGT	0.537000													38	99					0	0	0.003755	0	0
RP11-93K22.13	0	broad.mit.edu	37	3	129810120	129810120	+	RNA	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:129810120G>A	ENST00000514010.1	-	0	248				ALG1L2_ENST00000507643.1_RNA																							GACCGTCTACGACAAGCCGGC	0.552000													11	22					0	0	0.000978	0	0
KIAA1109	84162	broad.mit.edu	37	4	123207824	123207824	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:123207824G>A	ENST00000264501.4	+	53	9539	c.9166G>A	c.(9166-9168)Ggg>Agg	p.G3056R	KIAA1109_ENST00000455637.1_Missense_Mutation_p.G3056R|KIAA1109_ENST00000388738.3_Missense_Mutation_p.G3056R			Q2LD37	K1109_HUMAN	KIAA1109	3056					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						TACCATGTCAGGGAAATATAT	0.393000													31	42					0	0	0.003755	0	0
IGFBPL1	347252	broad.mit.edu	37	9	38411496	38411496	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:38411496G>A	ENST00000377694.1	-	4	760	c.738C>T	c.(736-738)gcC>gcT	p.A246A		NM_001007563.1	NP_001007564.1	Q8WX77	IBPL1_HUMAN	insulin-like growth factor binding protein-like 1	246	Ig-like C2-type.				regulation of cell growth	extracellular region	insulin-like growth factor binding			endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	4				GBM - Glioblastoma multiforme(29;0.0437)|Lung(182;0.116)		CCACCATGTTGGCTGCATGGC	0.488000													18	38					0	0	0.001216	0	0
ADAMTS19	171019	broad.mit.edu	37	5	129037197	129037197	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:129037197G>A	ENST00000274487.4	+	20	3198	c.3053G>A	c.(3052-3054)aGg>aAg	p.R1018K	CTC-575N7.1_ENST00000503616.1_RNA|ADAMTS19_ENST00000509467.1_3'UTR	NM_133638.3	NP_598377.3	Q8TE59	ATS19_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 19	1018	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(4)|endometrium(10)|kidney(9)|large_intestine(14)|lung(34)|ovary(6)|pancreas(1)|prostate(6)|skin(6)	91		all_cancers(142;0.0148)|Prostate(80;0.0494)|Breast(839;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.222)		GCCCGAGAGAGGGACTGCATT	0.582000													16	79					0	0	0.001216	0	0
FCRL1	115350	broad.mit.edu	37	1	157772381	157772381	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:157772381G>A	ENST00000358292.3	-	4	444	c.393C>T	c.(391-393)gtC>gtT	p.V131V	FCRL1_ENST00000368176.3_Silent_p.V131V|FCRL1_ENST00000489998.1_5'UTR|FCRL1_ENST00000491942.1_Silent_p.V131V	NM_001159397.1	NP_001152869.1	Q96LA6	FCRL1_HUMAN	Fc receptor-like 1	131	Ig-like C2-type 2.					integral to membrane|plasma membrane	receptor activity			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)|lung(24)|ovary(4)|prostate(1)|skin(6)	42	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			AGCAGATGAGGACCAGCCTGT	0.537000													41	12					0	0	0.001951	0	0
TIAM1	7074	broad.mit.edu	37	21	32639272	32639272	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:32639272C>T	ENST00000286827.3	-	5	488	c.17G>A	c.(16-18)aGt>aAt	p.S6N	TIAM1_ENST00000469412.1_Intron|TIAM1_ENST00000541036.1_Missense_Mutation_p.S6N	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	6					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						TACATGTTGACTTTCTGCGTT	0.532000													15	55					0	0	0.006122	0	0
CSMD1	64478	broad.mit.edu	37	8	3087615	3087615	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:3087615C>G	ENST00000520002.1	-	28	4850	c.4295G>C	c.(4294-4296)tGt>tCt	p.C1432S	CSMD1_ENST00000542608.1_Missense_Mutation_p.C1431S|CSMD1_ENST00000539096.1_Missense_Mutation_p.C1431S|CSMD1_ENST00000537824.1_Missense_Mutation_p.C1431S|CSMD1_ENST00000523387.1_5'UTR|CSMD1_ENST00000602723.1_Missense_Mutation_p.C1432S|CSMD1_ENST00000602557.1_Missense_Mutation_p.C1432S|CSMD1_ENST00000400186.3_Missense_Mutation_p.C1432S			Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1	1432	Sushi 8.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CAGCTGCACACAGGTGATTTT	0.478000													16	61					0	0	0.001523	0	0
CHODL	140578	broad.mit.edu	37	21	19629303	19629303	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:19629303G>A	ENST00000299295.2	+	3	797	c.406G>A	c.(406-408)Gaa>Aaa	p.E136K	CHODL_ENST00000400135.1_Missense_Mutation_p.E95K|CHODL_ENST00000543733.1_Missense_Mutation_p.E117K|CHODL_ENST00000400127.1_Missense_Mutation_p.E95K|CHODL_ENST00000400128.1_Missense_Mutation_p.E95K|CHODL_ENST00000338326.3_Missense_Mutation_p.E95K|CHODL_ENST00000400131.1_Missense_Mutation_p.E95K	NM_001204175.1|NM_024944.2	NP_001191104.1|NP_079220.2	Q9H9P2	CHODL_HUMAN	chondrolectin	136	C-type lectin.				muscle organ development	integral to membrane|perinuclear region of cytoplasm	sugar binding	p.E136*(1)		kidney(1)|large_intestine(3)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	12		all_epithelial(11;0.21)		Epithelial(23;0.000191)|all cancers(11;0.000827)|LUSC - Lung squamous cell carcinoma(23;0.00646)|Lung(58;0.0129)|OV - Ovarian serous cystadenocarcinoma(11;0.017)|COAD - Colon adenocarcinoma(22;0.03)|Colorectal(24;0.0917)		GTACACAGATGAACCTTCCTG	0.463000													21	40					0	0	0.001882	0	0
WBP2	23558	broad.mit.edu	37	17	73844682	73844682	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:73844682G>A	ENST00000591399.1	-	5	790	c.366C>T	c.(364-366)ttC>ttT	p.F122F	WBP2_ENST00000590221.1_Silent_p.F122F|WBP2_ENST00000585462.1_Silent_p.F100F|WBP2_ENST00000344296.4_Silent_p.F100F|WBP2_ENST00000254806.3_Silent_p.F122F|WBP2_ENST00000433525.2_Silent_p.F122F			Q969T9	WBP2_HUMAN	WW domain binding protein 2	122							protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)	7			all cancers(21;2.61e-06)|Epithelial(20;2.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			TCCGCTGTCCGAACTCAATGG	0.512000											OREG0024743	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	18					0	0	0.000978	0	0
CTNND2	1501	broad.mit.edu	37	5	10973618	10973618	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:10973618C>T	ENST00000304623.8	-	22	3814	c.3625G>A	c.(3625-3627)Gaa>Aaa	p.E1209K	CTNND2_ENST00000458100.2_Missense_Mutation_p.E776K|CTNND2_ENST00000511377.1_Missense_Mutation_p.E1118K|CTNND2_ENST00000503622.1_Missense_Mutation_p.E872K|CTNND2_ENST00000495388.2_5'UTR|CTNND2_ENST00000359640.2_Missense_Mutation_p.E1151K	NM_001332.2	NP_001323.1	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	1209					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|liver(1)|lung(71)|ovary(4)|pancreas(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	136						TAGTTCAGTTCACTGTAGGGA	0.612000													18	53					0	0	0.007413	0	0
SLIT2	9353	broad.mit.edu	37	4	20255468	20255468	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:20255468C>T	ENST00000504154.1	+	1	282	c.30C>T	c.(28-30)tcC>tcT	p.S10S	SLIT2_ENST00000503837.1_Silent_p.S10S|SLIT2_ENST00000503823.1_Silent_p.S10S|SLIT2_ENST00000273739.5_Silent_p.S10S	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	10					apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						AGATGCTGTCCCTGTCGCTGG	0.672000													25	111					0	0	0.003954	0	0
KLHL6	89857	broad.mit.edu	37	3	183273311	183273311	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:183273311C>T	ENST00000341319.3	-	1	166	c.131G>A	c.(130-132)gGg>gAg	p.G44E		NM_130446.2	NP_569713.2	Q8WZ60	KLHL6_HUMAN	kelch-like family member 6	44										breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(7)|kidney(1)|large_intestine(6)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	44	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			GACCTTTTCCCCATTTAAGAT	0.498000													34	110					0	0	0.003271	0	0
PDZD3	79849	broad.mit.edu	37	11	119059864	119059864	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:119059864G>A	ENST00000531114.1	+	8	2185	c.1636G>A	c.(1636-1638)Gcc>Acc	p.A546T	PDZD3_ENST00000355547.5_Missense_Mutation_p.A480T|PDZD3_ENST00000392817.2_Missense_Mutation_p.A546T|PDZD3_ENST00000525131.1_Missense_Mutation_p.A467T|PDZD3_ENST00000322712.4_Missense_Mutation_p.A466T			Q86UT5	NHRF4_HUMAN	PDZ domain containing 3	546	PDZ 4.				cGMP-mediated signaling|ion transport|negative regulation of cGMP biosynthetic process|response to toxin|water transport	apical part of cell|brush border|cytosol|membrane fraction|subapical complex	guanylate cyclase inhibitor activity|ion channel inhibitor activity|protein C-terminus binding			breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(1)|lung(4)|ovary(1)	14	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;7.52e-05)		GAAGCTGGCAGCCAGGTCTCT	0.597000													7	9					0	0	0.001984	0	0
PRRC2A	7916	broad.mit.edu	37	6	31594583	31594583	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31594583C>T	ENST00000376033.2	+	10	1251	c.1017C>T	c.(1015-1017)ctC>ctT	p.L339L	PRRC2A_ENST00000469577.1_3'UTR|PRRC2A_ENST00000376007.4_Silent_p.L339L	NM_004638.3	NP_004629.3	P48634	PRC2A_HUMAN	proline-rich coiled-coil 2A	339	2 X type B repeats.|4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding			breast(6)|central_nervous_system(1)|endometrium(7)|kidney(5)|large_intestine(14)|lung(19)|ovary(3)|pancreas(2)|prostate(4)|skin(5)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	70						CTGAAAAGCTCAAGTTCAGCG	0.527000													5	43					0	0	0.001984	0	0
MS4A6A	64231	broad.mit.edu	37	11	59949119	59949119	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:59949119C>T	ENST00000528851.1	-	2	222	c.82G>A	c.(82-84)Gaa>Aaa	p.E28K	MS4A6A_ENST00000533023.1_Missense_Mutation_p.E28K|MS4A6A_ENST00000530839.1_Missense_Mutation_p.E28K|MS4A6A_ENST00000529054.1_Missense_Mutation_p.E56K|MS4A6A_ENST00000420732.2_Missense_Mutation_p.E28K|MS4A6A_ENST00000426738.2_Missense_Mutation_p.E28K|MS4A6A_ENST00000323961.3_Missense_Mutation_p.E28K|MS4A6A_ENST00000412309.2_Missense_Mutation_p.E56K|MS4A6A_ENST00000532169.1_Missense_Mutation_p.E28K			Q9H2W1	M4A6A_HUMAN	membrane-spanning 4-domains, subfamily A, member 6A	28						integral to membrane	receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TTGGTGGGTTCGGGTTTCTCT	0.463000													40	59					0	0	0.002522	0	0
EMR1	2015	broad.mit.edu	37	19	6908774	6908774	+	Silent	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:6908774T>A	ENST00000312053.4	+	10	1150	c.1113T>A	c.(1111-1113)gtT>gtA	p.V371V	EMR1_ENST00000381404.4_Silent_p.V319V|EMR1_ENST00000450315.3_Silent_p.V194V|EMR1_ENST00000250572.8_Silent_p.V371V|EMR1_ENST00000381407.5_Silent_p.V230V	NM_001974.4	NP_001965.3	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone receptor-like 1	371	Ser/Thr-rich.				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(31)|ovary(3)|prostate(1)|skin(8)	62	all_hematologic(4;0.166)					CGACCGTAGTTTCTCTGAAGG	0.398000													24	29					0	0	0.003330	0	0
OR52E4	390081	broad.mit.edu	37	11	5905976	5905976	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:5905976G>A	ENST00000316987.2	+	1	476	c.454G>A	c.(454-456)Gga>Aga	p.G152R		NM_001005165.1	NP_001005165.1	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E, member 4	152					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(2)|prostate(1)|skin(2)	30		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGTGGTTGTTGGAAGAAATTT	0.463000													30	49					0	0	0.001512	0	0
GPR15	2838	broad.mit.edu	37	3	98251703	98251703	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:98251703C>T	ENST00000284311.3	+	1	961	c.826C>T	c.(826-828)Ccc>Tcc	p.P276S		NM_005290.1	NP_005281.1	P49685	GPR15_HUMAN	G protein-coupled receptor 15	276						integral to plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Lung NSC(201;7.93e-06)|all_neural(597;0.00172)|Hepatocellular(537;0.00825)|Myeloproliferative disorder(1037;0.0255)		Lung(72;0.246)		ACACTATTTACCCTCAGCTAT	0.468000													23	56					0	0	0.005443	0	0
SUCO	51430	broad.mit.edu	37	1	172578958	172578958	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:172578958G>C	ENST00000367723.3	+	23	3904	c.3780G>C	c.(3778-3780)aaG>aaC	p.K1260N	SUCO_ENST00000263688.3_Missense_Mutation_p.K1108N	NM_016227.2	NP_057311.2			SUN domain containing ossification factor																		TGTTGTAGAAGAAGCGCTGCA	0.398000													12	39					0	0	0.001855	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105924152	105924152	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:105924152G>A	ENST00000393359.2	-	2	1033	c.607C>T	c.(607-609)Ccc>Tcc	p.P203S	TGFBRAP1_ENST00000258449.1_Missense_Mutation_p.P203S			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	203	CNH.				regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						CTGCAGTAGGGAAACAGGTCC	0.607000													48	61					0	0	0.003610	0	0
FOXA3	3171	broad.mit.edu	37	19	46375569	46375569	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:46375569G>A	ENST00000302177.2	+	2	503	c.306G>A	c.(304-306)ggG>ggA	p.G102G		NM_004497.2	NP_004488.2	P55318	FOXA3_HUMAN	forkhead box A3	102					brain development|cellular glucose homeostasis|cellular response to starvation|chromatin modification|embryo development|endocrine pancreas development|negative regulation of cell proliferation|neural plate anterior/posterior regionalization|neuron fate specification|positive regulation of hepatocyte differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|spermatogenesis	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			breast(1)|endometrium(2)|large_intestine(2)|lung(4)|ovary(2)|pancreas(1)|prostate(1)	13		Ovarian(192;0.0308)|all_neural(266;0.0476)		OV - Ovarian serous cystadenocarcinoma(262;0.00453)|GBM - Glioblastoma multiforme(486;0.0518)|Epithelial(262;0.236)		TGGTGCACGGGAAGGAGATGC	0.687000													15	22					0	0	0.004007	0	0
GON4L	54856	broad.mit.edu	37	1	155796811	155796811	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:155796811G>C	ENST00000437809.1	-	3	636	c.514C>G	c.(514-516)Caa>Gaa	p.Q172E	GON4L_ENST00000271883.5_Missense_Mutation_p.Q172E|GON4L_ENST00000361040.5_Missense_Mutation_p.Q172E|GON4L_ENST00000368331.1_Missense_Mutation_p.Q172E|GON4L_ENST00000471341.1_5'UTR			Q3T8J9	GON4L_HUMAN	gon-4-like (C. elegans)	172					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			NS(2)|breast(4)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(7)|lung(10)|ovary(3)|prostate(3)|skin(2)|stomach(1)|urinary_tract(1)	45	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GAATTCATTTGAGGTTTCCCT	0.428000													12	69					0	0	0.002450	0	0
ANKAR	150709	broad.mit.edu	37	2	190593472	190593472	+	Missense_Mutation	SNP	C	C	T	rs149050269		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:190593472C>T	ENST00000520309.1	+	15	3206	c.3118C>T	c.(3118-3120)Cgc>Tgc	p.R1040C	ANKAR_ENST00000313581.4_Missense_Mutation_p.R1040C|ANKAR_ENST00000281412.6_Intron|ANKAR_ENST00000438402.2_Missense_Mutation_p.R1040C|ANKAR_ENST00000431575.2_Missense_Mutation_p.R969C	NM_144708.3	NP_653309.3	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1040						integral to membrane	binding			breast(3)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|liver(2)|lung(16)|ovary(2)|pancreas(1)|skin(1)|urinary_tract(2)	46			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			ACCATTGGTTCGCTTACTAAG	0.393000													26	29					0	0	0.004656	0	0
HOXB13	10481	broad.mit.edu	37	17	46804343	46804343	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:46804343G>A	ENST00000290295.7	-	2	1248	c.664C>T	c.(664-666)Ccg>Tcg	p.P222S		NM_006361.5	NP_006352.2	Q92826	HXB13_HUMAN	homeobox B13	222					angiogenesis|epidermis development|response to wounding		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|lung(6)|prostate(1)	11						TTGCTGTACGGAATGCGTTTC	0.627000													44	30					0	0	0.002852	0	0
TSPEAR	54084	broad.mit.edu	37	21	45941911	45941911	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:45941911G>A	ENST00000323084.4	-	9	1486	c.1421C>T	c.(1420-1422)tCc>tTc	p.S474F	C21orf90_ENST00000465978.1_Intron|TSPEAR_ENST00000397916.1_Missense_Mutation_p.S406F	NM_001272037.1|NM_144991.2	NP_001258966.1|NP_659428.2	Q8WU66	TSEAR_HUMAN	thrombospondin-type laminin G domain and EAR repeats	474					cell adhesion	extracellular region	structural molecule activity			breast(1)|central_nervous_system(6)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|skin(6)|soft_tissue(1)|upper_aerodigestive_tract(2)	37						GTAGGCGCCGGAGGTGGCGAT	0.607000													51	63					0	0	0.003610	0	0
CARD11	84433	broad.mit.edu	37	7	2963889	2963889	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2963889A>G	ENST00000396946.4	-	15	2321	c.1918T>C	c.(1918-1920)Ttc>Ctc	p.F640L		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	640					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		AACTTCCTGAACATGAGGTTG	0.592000			Mis		DLBCL								8	98					0	0	0.003080	0	0
TAAR8	83551	broad.mit.edu	37	6	132874354	132874354	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:132874354G>A	ENST00000275200.1	+	1	523	c.523G>A	c.(523-525)Ggg>Agg	p.G175R		NM_053278.1	NP_444508.1	Q969N4	TAAR8_HUMAN	trace amine associated receptor 8	175						plasma membrane	G-protein coupled receptor activity			endometrium(3)|large_intestine(2)|lung(14)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00412)|GBM - Glioblastoma multiforme(226;0.00792)		CAATGATGATGGGCTGGAGGA	0.468000													61	94					0	0	0.003610	0	0
C20orf26	26074	broad.mit.edu	37	20	20144803	20144803	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:20144803C>T	ENST00000245957.5	+	11	1212	c.1136C>T	c.(1135-1137)cCc>cTc	p.P379L	C20orf26_ENST00000377306.1_Missense_Mutation_p.P379L|C20orf26_ENST00000377309.2_5'UTR|C20orf26_ENST00000451767.2_Missense_Mutation_p.P379L|C20orf26_ENST00000389656.3_5'UTR	NM_015585.3	NP_056400.3	Q8NHU2	CT026_HUMAN	chromosome 20 open reading frame 26	379										NS(2)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(42)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	77				READ - Rectum adenocarcinoma(2;0.171)		CACTTCCGCCCCATCTACAGG	0.498000													21	91					0	0	0.001882	0	0
TRAM1L1	133022	broad.mit.edu	37	4	118006361	118006361	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:118006361C>T	ENST00000310754.4	-	1	375	c.189G>A	c.(187-189)gaG>gaA	p.E63E		NM_152402.2	NP_689615.2	Q8N609	TR1L1_HUMAN	translocation associated membrane protein 1-like 1	63					protein transport|transmembrane transport	endoplasmic reticulum membrane|integral to membrane				central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	22						TGGCTTGTTCCTCTGCTGCAG	0.493000													12	15					0	0	0.001368	0	0
GYS2	2998	broad.mit.edu	37	12	21733318	21733318	+	Silent	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:21733318A>C	ENST00000261195.2	-	2	515	c.261T>G	c.(259-261)gcT>gcG	p.A87A		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	87					glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						CTCTTCTGACAGCATCATTTA	0.418000													41	63					0	0	0.003610	0	0
CDON	50937	broad.mit.edu	37	11	125859626	125859626	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:125859626G>A	ENST00000392693.3	-	15	2806	c.2679C>T	c.(2677-2679)caC>caT	p.H893H	CDON_ENST00000263577.7_Silent_p.H893H|CDON_ENST00000531738.1_Silent_p.H270H	NM_001243597.1|NM_016952.4	NP_001230526.1|NP_058648.4	Q4KMG0	CDON_HUMAN	cell adhesion associated, oncogene regulated	893	Fibronectin type-III 3.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|lung(9)|ovary(3)|prostate(2)|skin(4)|stomach(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	61	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		CTGGCTGCAGGTGGCCAATCA	0.368000													30	5					0	0	0.006320	0	0
SPTBN4	57731	broad.mit.edu	37	19	41066344	41066344	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:41066344C>T	ENST00000595535.1	+	27	6036	c.5950C>T	c.(5950-5952)Ccc>Tcc	p.P1984S	SPTBN4_ENST00000392023.1_Missense_Mutation_p.P660S|SPTBN4_ENST00000598249.1_Intron|SPTBN4_ENST00000338932.3_Intron|SPTBN4_ENST00000392025.1_Intron|SPTBN4_ENST00000352632.3_Intron			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	0					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TCCTGCCTCCCCCTGGTGGCC	0.637000													18	9					0	0	0.007413	0	0
DCDC2	51473	broad.mit.edu	37	6	24205394	24205394	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:24205394G>A	ENST00000378450.3	-	1	137	c.118C>T	c.(118-120)Cca>Tca	p.P40S	DCDC2_ENST00000378454.3_Intron			Q9UHG0	DCDC2_HUMAN	doublecortin domain containing 2	68	Doublecortin 1.				cellular defense response|intracellular signal transduction|neuron migration					breast(1)|endometrium(2)|kidney(3)|large_intestine(8)|lung(12)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	32		Ovarian(999;0.101)				CTGAATGCTGGAATTACAATC	0.413000													31	123					0	0	0.001512	0	0
TCAIM	285343	broad.mit.edu	37	3	44434423	44434423	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:44434423C>T	ENST00000342649.4	+	6	1076	c.649C>T	c.(649-651)Cgt>Tgt	p.R217C	TCAIM_ENST00000417237.1_Missense_Mutation_p.R217C	NM_173826.3	NP_776187.2			T cell activation inhibitor, mitochondrial									p.R217C(1)									AGAACTAGATCGTTTAAAAGA	0.323000													34	93					0	0	0.002096	0	0
DENND5A	23258	broad.mit.edu	37	11	9164310	9164310	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:9164310G>A	ENST00000328194.3	-	21	3790	c.3470C>T	c.(3469-3471)tCg>tTg	p.S1157L	DENND5A_ENST00000530044.1_Missense_Mutation_p.S1157L|DENND5A_ENST00000527700.1_Missense_Mutation_p.S500L	NM_001243254.1|NM_015213.3	NP_001230183.1|NP_056028.2	Q6IQ26	DEN5A_HUMAN	DENN/MADD domain containing 5A	1157	RUN 2.									breast(1)|endometrium(7)|kidney(2)|large_intestine(8)|liver(1)|lung(16)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39						GAGCCGGGGCGATTTAAATCC	0.517000													54	59					0	0	0.003610	0	0
ZSCAN18	65982	broad.mit.edu	37	19	58598357	58598357	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:58598357C>T	ENST00000240727.6	-	5	1060	c.661G>A	c.(661-663)Gag>Aag	p.E221K	ZSCAN18_ENST00000600404.1_Missense_Mutation_p.E277K|ZSCAN18_ENST00000601144.1_Missense_Mutation_p.E221K|ZSCAN18_ENST00000421612.2_Missense_Mutation_p.E86K	NM_023926.4	NP_076415.3	Q8TBC5	ZSC18_HUMAN	zinc finger and SCAN domain containing 18	221					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|skin(3)	19		Colorectal(82;0.000256)|all_neural(62;0.0412)|Breast(46;0.114)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		TGAGGGTCCTCTGGAAAGGAC	0.637000													8	57					0	0	0.004482	0	0
PDE7B	27115	broad.mit.edu	37	6	136429878	136429878	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:136429878G>A	ENST00000308191.6	+	3	395	c.92G>A	c.(91-93)cGa>cAa	p.R31Q	RP13-143G15.4_ENST00000591521.1_RNA|RP13-143G15.4_ENST00000585946.1_RNA|RP13-143G15.4_ENST00000417643.1_RNA	NM_018945.3	NP_061818.1	Q9NP56	PDE7B_HUMAN	phosphodiesterase 7B	31					signal transduction|synaptic transmission	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|kidney(1)|large_intestine(5)|lung(7)|ovary(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	21	Colorectal(23;0.24)			OV - Ovarian serous cystadenocarcinoma(155;0.0136)|GBM - Glioblastoma multiforme(68;0.0147)	Dyphylline(DB00651)|Ketotifen(DB00920)	GGAGATATACGACTAAGGGGT	0.463000													39	42					0	0	0.006230	0	0
USP6	9098	broad.mit.edu	37	17	5036747	5036747	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:5036747C>T	ENST00000574788.1	+	14	2516	c.286C>T	c.(286-288)Cga>Tga	p.R96*	USP6_ENST00000332776.4_Nonsense_Mutation_p.R96*|USP6_ENST00000250066.6_Nonsense_Mutation_p.R96*|USP6_ENST00000304328.5_5'UTR|USP6_ENST00000572429.1_3'UTR			P35125	UBP6_HUMAN	ubiquitin specific peptidase 6 (Tre-2 oncogene)	96					protein deubiquitination|regulation of vesicle-mediated transport|ubiquitin-dependent protein catabolic process	lysosome|plasma membrane|recycling endosome	calmodulin binding|cysteine-type endopeptidase activity|nucleic acid binding|protein binding|Rab GTPase activator activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	34						GCTCATAGATCGAGTGTACAA	0.522000			T	"""COL1A1, CDH11, ZNF9, OMD"""	aneurysmal bone cysts								26	49					0	0	0.001512	0	0
DYRK2	8445	broad.mit.edu	37	12	68043584	68043584	+	Silent	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:68043584T>A	ENST00000344096.3	+	2	470	c.57T>A	c.(55-57)ggT>ggA	p.G19G	DYRK2_ENST00000537632.1_3'UTR|DYRK2_ENST00000393555.3_Intron	NM_006482.2	NP_006473.2	Q92630	DYRK2_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2	19					apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|positive regulation of glycogen biosynthetic process|smoothened signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|manganese ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	30			Lung(24;6.81e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|LUSC - Lung squamous cell carcinoma(43;0.196)	GBM - Glioblastoma multiforme(7;0.000573)		CAGGCCGAGGTGGGGACAGCG	0.711000													6	16					0	0	0.006214	0	0
PCDH12	51294	broad.mit.edu	37	5	141335404	141335404	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:141335404C>T	ENST00000231484.3	-	1	3223	c.2013G>A	c.(2011-2013)tgG>tgA	p.W671*		NM_016580.2	NP_057664.1	Q9NPG4	PCD12_HUMAN	protocadherin 12	671	Cadherin 6.				neuron recognition	integral to plasma membrane	calcium ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(14)|ovary(3)|prostate(2)|skin(1)	38		all_hematologic(541;0.0999)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTCCAGCTCCCACTCACTCC	0.567000													16	23					0	0	0.004990	0	0
ZNF831	128611	broad.mit.edu	37	20	57769762	57769762	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:57769762G>A	ENST00000371030.2	+	1	3688	c.3688G>A	c.(3688-3690)Gga>Aga	p.G1230R		NM_178457.1	NP_848552.1	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	1230						intracellular	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(71)|ovary(2)|pancreas(1)|prostate(4)|skin(16)|upper_aerodigestive_tract(2)|urinary_tract(3)	125	all_lung(29;0.0085)					GAGCAATGGAGGATGGACCTG	0.607000													6	15					0	0	0.003080	0	0
LGI2	55203	broad.mit.edu	37	4	25030200	25030200	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:25030200C>T	ENST00000382114.4	-	2	383	c.197_splice	c.e2-1	p.L66_splice		NM_018176.3	NP_060646.2	Q8N0V4	LGI2_HUMAN	leucine-rich repeat LGI family, member 2	66						extracellular region				breast(2)|endometrium(2)|kidney(2)|large_intestine(6)|lung(15)|prostate(1)|skin(3)|stomach(2)	33		Breast(46;0.173)				TTACCAGGCTCCTACGGGCAA	0.478000													5	43					0	0	0.001168	0	0
NRG1	3084	broad.mit.edu	37	8	32453407	32453407	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:32453407C>T	ENST00000341377.5	+	2	679	c.162C>T	c.(160-162)gtC>gtT	p.V54V	NRG1_ENST00000287840.5_Silent_p.V54V|NRG1_ENST00000521670.1_Silent_p.V54V|NRG1_ENST00000405005.2_Silent_p.V54V|NRG1_ENST00000287845.5_Silent_p.V54V|NRG1_ENST00000287842.3_Silent_p.V54V|NRG1_ENST00000338921.4_Silent_p.V54V|NRG1_ENST00000523079.1_Silent_p.V54V|NRG1_ENST00000519301.1_Silent_p.V33V|NRG1_ENST00000356819.4_Silent_p.V54V|NRG1_ENST00000520407.1_Silent_p.V269V			Q02297	NRG1_HUMAN	neuregulin 1	54	Ig-like C2-type.				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		CCAAACTAGTCCTTCGGTGTG	0.403000													29	101					0	0	0.002445	0	0
NCKAP5	344148	broad.mit.edu	37	2	133542791	133542791	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:133542791C>T	ENST00000409261.1	-	14	1966	c.1593G>A	c.(1591-1593)aaG>aaA	p.K531K	NCKAP5_ENST00000317721.6_Silent_p.K531K|NCKAP5_ENST00000405974.3_Intron|NCKAP5_ENST00000409213.1_Intron	NM_207363.2	NP_997246.2	O14513	NCKP5_HUMAN	NCK-associated protein 5	531							protein binding			NS(4)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(29)|lung(51)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	118						CAGGCCTTTCCTTGGGATAAA	0.517000													51	54					0	0	0.003610	0	0
SNRNP200	23020	broad.mit.edu	37	2	96953256	96953256	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:96953256G>A	ENST00000323853.5	-	26	3482	c.3405C>T	c.(3403-3405)ctC>ctT	p.L1135L	SNRNP200_ENST00000349783.5_Intron	NM_014014.4	NP_054733.2	O75643	U520_HUMAN	small nuclear ribonucleoprotein 200kDa (U5)	1135	SEC63 1.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(18)|lung(37)|ovary(7)|prostate(4)|skin(5)|stomach(1)|urinary_tract(1)	90						CTTCCTCAGGGAGTTTCCGGA	0.517000													30	49					0	0	0.007291	0	0
ZFP28	140612	broad.mit.edu	37	19	57051083	57051083	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57051083C>T	ENST00000301318.3	+	2	369	c.298C>T	c.(298-300)Cag>Tag	p.Q100*	ZFP28_ENST00000594386.1_3'UTR|ZFP28_ENST00000591844.1_Nonsense_Mutation_p.Q100*	NM_020828.1	NP_065879.1	Q8NHY6	ZFP28_HUMAN	ZFP28 zinc finger protein	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(6)|ovary(1)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)	35		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0302)		AGCCATGTCCCAGGTGAGTTG	0.458000													5	23					0	0	0.000602	0	0
SLC16A9	220963	broad.mit.edu	37	10	61413888	61413888	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:61413888G>A	ENST00000395348.3	-	5	1532	c.896C>T	c.(895-897)gCt>gTt	p.A299V	SLC16A9_ENST00000395347.1_Missense_Mutation_p.A299V	NM_194298.2	NP_919274.1	Q7RTY1	MOT9_HUMAN	solute carrier family 16, member 9	299					urate metabolic process	integral to membrane|plasma membrane	symporter activity			kidney(3)|large_intestine(5)|lung(5)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	23						TTTAAAAAGAGCCACAGTTTC	0.368000													30	33					0	0	0.007291	0	0
PRND	23627	broad.mit.edu	37	20	4705197	4705197	+	Translation_Start_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:4705197G>A	ENST00000305817.2	+	0	71					NM_012409.2	NP_036541.2	Q9UKY0	PRND_HUMAN	prion protein 2 (dublet)						protein homooligomerization	anchored to membrane|plasma membrane				breast(3)|endometrium(2)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(1)	13						GTTCTGACGCGATGAGGAAGC	0.617000													34	68					0	0	0.003271	0	0
ULBP2	80328	broad.mit.edu	37	6	150266536	150266536	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:150266536G>A	ENST00000367351.3	+	2	250	c.177G>A	c.(175-177)aaG>aaA	p.K59K		NM_025217.2	NP_079493.1	Q9BZM5	N2DL2_HUMAN	UL16 binding protein 2	59	MHC class I alpha-1 like.				antigen processing and presentation|immune response|natural killer cell activation|regulation of immune response	anchored to membrane|cell surface|extracellular space|MHC class I protein complex	MHC class I receptor activity			breast(3)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|skin(1)	10		Ovarian(120;0.0907)	BRCA - Breast invasive adenocarcinoma(37;0.193)	OV - Ovarian serous cystadenocarcinoma(155;2.58e-12)		TGGATGAAAAGACTTTTCTTC	0.512000													37	43					0	0	0.002222	0	0
MYBPC3	4607	broad.mit.edu	37	11	47356689	47356689	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:47356689C>T	ENST00000399249.2	-	26	2863	c.2809G>A	c.(2809-2811)Ggg>Agg	p.G937R	MYBPC3_ENST00000256993.4_Missense_Mutation_p.G936R|MYBPC3_ENST00000545968.1_Missense_Mutation_p.G937R			Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	936	Fibronectin type-III 2.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		AGCCGGGCCCCCGTGGGCAGG	0.662000													17	19					0	0	0.004990	0	0
TG	7038	broad.mit.edu	37	8	133899220	133899220	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:133899220C>T	ENST00000220616.4	+	9	1643	c.1603C>T	c.(1603-1605)Cct>Tct	p.P535S	TG_ENST00000377869.1_Missense_Mutation_p.P535S	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	535					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CACAGGAACCCCTGAAGCTGC	0.448000													12	70					0	0	0.002450	0	0
ACBD4	79777	broad.mit.edu	37	17	43215092	43215092	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:43215092C>T	ENST00000431281.1	+	9	975	c.506C>T	c.(505-507)tCc>tTc	p.S169F	ACBD4_ENST00000592162.1_Intron|ACBD4_ENST00000586346.1_Missense_Mutation_p.S169F|ACBD4_ENST00000376955.4_Intron|ACBD4_ENST00000398322.3_Intron|ACBD4_ENST00000591859.1_Missense_Mutation_p.S169F|ACBD4_ENST00000321854.8_Intron|ACBD4_ENST00000591136.1_Intron	NM_001135704.1	NP_001129176.1	Q8NC06	ACBD4_HUMAN	acyl-CoA binding domain containing 4	169							fatty-acyl-CoA binding			kidney(1)|lung(3)|ovary(1)	5						TCCACAGCTTCCCTCTGGGCA	0.562000													31	86					0	0	0.003755	0	0
CHD6	84181	broad.mit.edu	37	20	40054786	40054786	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:40054786G>A	ENST00000373233.3	-	28	4253	c.4076C>T	c.(4075-4077)tCc>tTc	p.S1359F		NM_032221.3	NP_115597.3	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1359					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(24)|lung(53)|ovary(8)|prostate(5)|skin(8)|stomach(1)|urinary_tract(9)	129		Myeloproliferative disorder(115;0.00425)				TCCATCACTGGAACTCTCCTA	0.453000													47	125					0	0	0.003610	0	0
KRT33A	3883	broad.mit.edu	37	17	39504771	39504771	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:39504771C>T	ENST00000007735.3	-	3	596	c.552G>A	c.(550-552)aaG>aaA	p.K184K		NM_004138.3	NP_004129.2	O76009	KT33A_HUMAN	keratin 33A	184	Coil 1B.|Rod.					intermediate filament	protein binding|structural molecule activity			endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	21		Breast(137;0.000496)				GCAGCTCCTCCTTCAGGGACT	0.597000													21	56					0	0	0.002299	0	0
IRGC	56269	broad.mit.edu	37	19	44223121	44223121	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:44223121C>T	ENST00000244314.5	+	2	610	c.411C>T	c.(409-411)ttC>ttT	p.F137F		NM_019612.3	NP_062558.1	Q6NXR0	IIGP5_HUMAN	immunity-related GTPase family, cinema	137						membrane	GTP binding|hydrolase activity, acting on acid anhydrides			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(16)|ovary(1)|prostate(1)|skin(2)	25		Prostate(69;0.0435)				ATGACTTCTTCCTGCTGGTCT	0.642000													10	6					0	0	0.006214	0	0
LHX9	56956	broad.mit.edu	37	1	197889123	197889123	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:197889123G>A	ENST00000367390.3	+	3	196	c.169G>A	c.(169-171)Gag>Aag	p.E57K	LHX9_ENST00000337020.2_Missense_Mutation_p.E66K|LHX9_ENST00000561173.1_Missense_Mutation_p.E72K|LHX9_ENST00000367387.4_Missense_Mutation_p.E66K|LHX9_ENST00000367391.1_Missense_Mutation_p.E57K	NM_001014434.1	NP_001014434.1	Q9NQ69	LHX9_HUMAN	LIM homeobox 9	66					motor axon guidance|negative regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			endometrium(8)|kidney(1)|large_intestine(6)|liver(2)|lung(14)|ovary(2)|skin(1)|stomach(1)	35						GCTCAGCCCGGAGAAGCCCGC	0.662000													35	123					0	0	0.004289	0	0
MUC16	94025	broad.mit.edu	37	19	9066587	9066587	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9066587C>T	ENST00000397910.4	-	3	21062	c.20859G>A	c.(20857-20859)ctG>ctA	p.L6953L		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6955	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.L6953L(2)|p.L2586L(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGTCTCTCTCAGTCCAGGAG	0.458000													48	64					0	0	0.003214	0	0
TRIOBP	11078	broad.mit.edu	37	22	38150944	38150944	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:38150944C>T	ENST00000406386.3	+	13	5695	c.5440C>T	c.(5440-5442)Ctg>Ttg	p.L1814L	TRIOBP_ENST00000407319.2_Silent_p.L101L|RP1-37E16.12_ENST00000455236.1_RNA|TRIOBP_ENST00000403663.2_Silent_p.L101L	NM_001039141.2	NP_001034230.1	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein	1814	PH.				actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	12	Melanoma(58;0.0574)					TTGGTTTGTGCTGACAGATTC	0.547000													11	98					0	0	0.001368	0	0
VIPR2	7434	broad.mit.edu	37	7	158827272	158827272	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:158827272G>A	ENST00000262178.2	-	9	1064	c.879_splice	c.e9+1	p.I293_splice	VIPR2_ENST00000402066.1_Splice_Site_p.I434_splice|VIPR2_ENST00000377633.3_Splice_Site_p.I277_splice	NM_003382.4	NP_003373.2	P41587	VIPR2_HUMAN	vasoactive intestinal peptide receptor 2	293					cell-cell signaling	integral to plasma membrane				central_nervous_system(1)|kidney(1)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(1)|stomach(1)	22	Ovarian(565;0.152)	all_cancers(7;1.13e-11)|all_epithelial(9;0.000545)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00231)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)|STAD - Stomach adenocarcinoma(7;0.18)		GACTACTTACGATGATGGAAA	0.458000													27	35					0	0	0.001786	0	0
PLIN4	729359	broad.mit.edu	37	19	4510756	4510756	+	Silent	SNP	G	G	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:4510756G>T	ENST00000301286.3	-	3	3173	c.3174C>A	c.(3172-3174)acC>acA	p.T1058T		NM_001080400.1	NP_001073869.1	Q96Q06	PLIN4_HUMAN	perilipin 4	1058						lipid particle|plasma membrane				NS(2)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|soft_tissue(1)|stomach(2)	41						CATTGTCTGTGGTCCTGGAAC	0.652000													14	15					0.000422831	0.000715323	0.004007	1	0
CNGB3	54714	broad.mit.edu	37	8	87588331	87588331	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:87588331C>T	ENST00000320005.5	-	18	2178	c.2131G>A	c.(2131-2133)Gaa>Aaa	p.E711K		NM_019098.4	NP_061971.3	Q9NQW8	CNGB3_HUMAN	cyclic nucleotide gated channel beta 3	711					signal transduction|visual perception	integral to membrane	cGMP binding			NS(1)|breast(2)|endometrium(4)|kidney(6)|large_intestine(15)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	80						tttccttcttcctctcctcct	0.284000													10	32					0	0	0.006214	0	0
PDZD2	23037	broad.mit.edu	37	5	31983414	31983414	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:31983414G>A	ENST00000438447.1	+	3	1018	c.630G>A	c.(628-630)gcG>gcA	p.A210A	PDZD2_ENST00000282493.3_Silent_p.A210A			O15018	PDZD2_HUMAN	PDZ domain containing 2	210					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						ACCGAACTGCGAAAAAGGGGA	0.537000													20	63					0	0	0.002299	0	0
GPR148	344561	broad.mit.edu	37	2	131487718	131487718	+	Missense_Mutation	SNP	C	C	T	rs147782890		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:131487718C>T	ENST00000309926.4	+	1	1076	c.994C>T	c.(994-996)Cgg>Tgg	p.R332W		NM_207364.2	NP_997247.2	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	332						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(15)|skin(3)|upper_aerodigestive_tract(1)	27	Colorectal(110;0.1)					GGGCATGGTCCGGGGCCACCT	0.542000													7	14					0	0	0.001984	0	0
KCTD5	54442	broad.mit.edu	37	16	2749829	2749829	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:2749829T>G	ENST00000301738.4	+	4	535	c.461T>G	c.(460-462)gTg>gGg	p.V154G	KCTD5_ENST00000564195.1_Missense_Mutation_p.C123W	NM_018992.3	NP_061865.1	Q9NXV2	KCTD5_HUMAN	potassium channel tetramerization domain containing 5	154					interspecies interaction between organisms	cytosol|nucleus|voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			haematopoietic_and_lymphoid_tissue(1)|lung(1)	2						CAGGTGCCTGTGAAGCATGTG	0.647000													26	26					0	0	0.001786	0	0
RRP12	23223	broad.mit.edu	37	10	99141234	99141234	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:99141234G>A	ENST00000370992.4	-	12	1438	c.1327C>T	c.(1327-1329)Ctg>Ttg	p.L443L	RRP12_ENST00000414986.1_Silent_p.L382L|RRP12_ENST00000536831.1_Silent_p.L161L|RRP12_ENST00000315563.6_Silent_p.L343L	NM_015179.3	NP_055994.2	Q5JTH9	RRP12_HUMAN	ribosomal RNA processing 12 homolog (S. cerevisiae)	443						integral to membrane|nuclear membrane|nucleolus	protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(2)|lung(13)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	37		Colorectal(252;0.162)		Epithelial(162;2.72e-09)|all cancers(201;1.76e-07)		CATTCCTTCAGGATCTCCTGC	0.597000													9	6					0	0	0.000978	0	0
TECTA	7007	broad.mit.edu	37	11	120998869	120998869	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:120998869C>T	ENST00000392793.1	+	9	2454	c.2183C>T	c.(2182-2184)tCc>tTc	p.S728F	TECTA_ENST00000264037.2_Missense_Mutation_p.S728F			O75443	TECTA_HUMAN	tectorin alpha	728	VWFD 2.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix			TECTA/TBCEL(2)	NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(38)|liver(1)|lung(46)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(1)	135	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		GACGGCGCCTCCTACGCCTTC	0.617000													32	30					0	0	0.004289	0	0
KRT6B	3854	broad.mit.edu	37	12	52841607	52841607	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:52841607A>C	ENST00000252252.3	-	7	1426	c.1379T>G	c.(1378-1380)gTg>gGg	p.V460G		NM_005555.3	NP_005546.2	P04259	K2C6B_HUMAN	keratin 6B	460	Coil 2.|Rod.				ectoderm development	keratin filament	structural constituent of cytoskeleton			NS(1)|breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(19)|ovary(4)|prostate(2)	40				BRCA - Breast invasive adenocarcinoma(357;0.083)		GGCGATCTCCACATCCAGGGC	0.612000													29	84					0	0	0.003271	0	0
SCRIB	23513	broad.mit.edu	37	8	144893232	144893232	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:144893232G>A	ENST00000356994.2	-	11	1123	c.1117C>T	c.(1117-1119)Ctg>Ttg	p.L373L	SCRIB_ENST00000320476.3_Silent_p.L373L|SCRIB_ENST00000377533.3_Silent_p.L292L	NM_182706.4	NP_874365.3	Q14160	SCRIB_HUMAN	scribbled planar cell polarity protein	373	Sufficient for targeting to adherens junction and to inhibit cell proliferation.				activation of Rac GTPase activity|apoptosis involved in morphogenesis|cell migration|cell proliferation|cell-cell adhesion|establishment of apical/basal cell polarity|interspecies interaction between organisms|mammary gland duct morphogenesis|negative regulation of mitotic cell cycle|positive chemotaxis|positive regulation of apoptosis|positive regulation of receptor recycling|protein localization to adherens junction	cell-cell adherens junction|Scrib-APC-beta-catenin complex	protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|lung(20)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	42	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;1.12e-34)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			GCGAACGGCAGACTCTGCAGG	0.692000													6	24					0	0	0.001984	0	0
THSD4	79875	broad.mit.edu	37	15	72039234	72039234	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:72039234C>T	ENST00000355327.3	+	13	2228	c.2094C>T	c.(2092-2094)caC>caT	p.H698H	THSD4_ENST00000261862.6_Silent_p.H698H|THSD4_ENST00000357769.4_Silent_p.H338H|THSD4_ENST00000567838.1_3'UTR			Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	698	TSP type-1 2.					proteinaceous extracellular matrix	metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(20)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42						GCATGCAGCACCGCCAGGTTC	0.627000													16	15					0	0	0.001216	0	0
CD8B	926	broad.mit.edu	37	2	87042831	87042831	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:87042831C>T	ENST00000349455.3	-	5	590	c.541G>A	c.(541-543)Gaa>Aaa	p.E181K	CD8B_ENST00000393759.2_3'UTR|CD8B_ENST00000331469.2_Missense_Mutation_p.E211K|CD8B_ENST00000393761.2_Silent_p.G168G	NM_172102.3	NP_742100.1	P10966	CD8B_HUMAN	CD8b molecule	0					immune response|regulation of defense response to virus by virus|regulation of immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway|viral reproduction	early endosome|extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	13						GATATACCTTCCCCTTGAGGC	0.408000													71	144					0	0	0.003610	0	0
IGF1R	3480	broad.mit.edu	37	15	99500576	99500576	+	Missense_Mutation	SNP	C	C	T	rs141802822	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:99500576C>T	ENST00000268035.6	+	21	4620	c.4009C>T	c.(4009-4011)Cgc>Tgc	p.R1337C	RP11-654A16.3_ENST00000559468.1_RNA|IGF1R_ENST00000558762.1_Missense_Mutation_p.R1336C	NM_000875.3	NP_000866.1	P08069	IGF1R_HUMAN	insulin-like growth factor 1 receptor	1337					anti-apoptosis|immune response|insulin receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of DNA replication|protein autophosphorylation|protein tetramerization	microsome	ATP binding|identical protein binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor receptor activity|metal ion binding|phosphatidylinositol 3-kinase binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(13)|lung(20)|ovary(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	63	all_cancers(4;4.17e-14)|all_epithelial(3;4.34e-15)|Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00505)|Medulloblastoma(229;0.163)		Epithelial(2;1.94e-12)|all cancers(5;6.83e-11)|BRCA - Breast invasive adenocarcinoma(2;2.88e-09)|OV - Ovarian serous cystadenocarcinoma(32;0.00261)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Mecasermin(DB01277)	GCTGGTCCTCCGCGCCAGCTT	0.687000													11	15					0	0	0.000978	0	0
NYAP2	57624	broad.mit.edu	37	2	226446676	226446676	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:226446676C>T	ENST00000272907.6	+	4	956	c.543C>T	c.(541-543)ccC>ccT	p.P181P	NYAP2_ENST00000409269.2_Intron	NM_020864.1	NP_065915.1	Q9P242	K1486_HUMAN	neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2	181																	AACCAAGACCCCACAGCGATG	0.398000													42	61					0	0	0.003610	0	0
CRYBA4	1413	broad.mit.edu	37	22	27026391	27026391	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:27026391G>A	ENST00000354760.3	+	6	566	c.531G>A	c.(529-531)cgG>cgA	p.R177R	CRYBA4_ENST00000466315.1_3'UTR	NM_001886.2	NP_001877.1	P53673	CRBA4_HUMAN	crystallin, beta A4	177	Beta/gamma crystallin 'Greek key' 4.				camera-type eye development|visual perception	soluble fraction	structural constituent of eye lens			large_intestine(6)|liver(1)|lung(6)|skin(3)|urinary_tract(2)	18						AACATTTCCGGGAGTGGGGCT	0.572000													11	21					0	0	0.000978	0	0
IFT20	90410	broad.mit.edu	37	17	26659002	26659002	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:26659002C>T	ENST00000585089.1	-	3	358	c.88G>A	c.(88-90)Gac>Aac	p.D30N	IFT20_ENST00000395418.3_Missense_Mutation_p.D4N|IFT20_ENST00000578122.1_Missense_Mutation_p.D30N|IFT20_ENST00000579419.1_Missense_Mutation_p.D4N|IFT20_ENST00000578985.1_Missense_Mutation_p.D30N|IFT20_ENST00000357896.3_Missense_Mutation_p.D4N|IFT20_ENST00000585313.1_Missense_Mutation_p.D4N	NM_001267774.1	NP_001254703.1	Q8IY31	IFT20_HUMAN	intraflagellar transport 20 homolog (Chlamydomonas)	4					cell projection organization	centriole|cilium|Golgi apparatus|microtubule basal body	protein binding			lung(2)	2	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		CCCAGGATGTCCTTGGCCATG	0.552000													44	27					0	0	0.003610	0	0
SMG8	55181	broad.mit.edu	37	17	57290426	57290426	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:57290426C>T	ENST00000543872.2	+	4	2506	c.2242C>T	c.(2242-2244)Cca>Tca	p.P748S	CTD-2510F5.6_ENST00000577660.1_Intron|SMG8_ENST00000300917.5_Missense_Mutation_p.P748S|SMG8_ENST00000580498.1_3'UTR			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	748					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						TGAGTATCTCCCAGGCATGCT	0.443000													70	29					0	0	0.003610	0	0
USP9X	8239	broad.mit.edu	37	X	41075159	41075159	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:41075159C>T	ENST00000324545.7	+	35	5972	c.5339C>T	c.(5338-5340)aCc>aTc	p.T1780I	USP9X_ENST00000378308.2_Missense_Mutation_p.T1780I	NM_001039590.2|NM_001039591.2	NP_001034679.2|NP_001034680.2	Q93008	USP9X_HUMAN	ubiquitin specific peptidase 9, X-linked	1780					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			NS(3)|breast(6)|central_nervous_system(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(16)|lung(29)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	87						TAGGTTGATACCGTAAAGCGC	0.323000													12	1					0	0	0.003163	0	0
PTGES2	80142	broad.mit.edu	37	9	130883435	130883435	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:130883435G>A	ENST00000338961.6	-	7	1867	c.1123C>T	c.(1123-1125)Cca>Tca	p.P375S	PTGES2_ENST00000277462.5_Missense_Mutation_p.P184S	NM_001256335.1|NM_025072.6	NP_001243264.1|NP_079348.1	Q9H7Z7	PGES2_HUMAN	prostaglandin E synthase 2	375	GST C-terminal.				cell redox homeostasis|prostaglandin biosynthetic process	Golgi membrane|integral to membrane|mitochondrion|perinuclear region of cytoplasm	electron carrier activity|prostaglandin-E synthase activity|protein binding|protein disulfide oxidoreductase activity			endometrium(1)|large_intestine(1)|lung(2)	4						CAGTGCGCTGGGGAGGCCTCG	0.672000													5	5					0	0	0.003080	0	0
MISP	126353	broad.mit.edu	37	19	757283	757283	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:757283C>T	ENST00000215582.6	+	2	440	c.337C>T	c.(337-339)Cca>Tca	p.P113S		NM_173481.2	NP_775752.1			mitotic spindle positioning																		GGCACTCCGCCCAGAGGACGG	0.672000													13	15					0	0	0.001855	0	0
TRPC4	7223	broad.mit.edu	37	13	38320211	38320211	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:38320211C>T	ENST00000379705.3	-	3	1617	c.760G>A	c.(760-762)Gac>Aac	p.D254N	TRPC4_ENST00000355779.2_Missense_Mutation_p.D254N|TRPC4_ENST00000426868.2_Missense_Mutation_p.D254N|TRPC4_ENST00000358477.2_Missense_Mutation_p.D254N|TRPC4_ENST00000379673.2_Missense_Mutation_p.D254N|TRPC4_ENST00000379681.3_Missense_Mutation_p.D254N|TRPC4_ENST00000379679.1_Intron|TRPC4_ENST00000447043.1_Missense_Mutation_p.D254N|TRPC4_ENST00000338947.5_Intron			Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel, subfamily C, member 4	254	Multimerization domain (By similarity).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			NS(2)|breast(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(26)|lung(30)|ovary(4)|prostate(1)|skin(4)|urinary_tract(2)	83				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TCCAGTAGGTCCTTAGCAAAT	0.413000													37	56					0	0	0.005524	0	0
PCDH17	27253	broad.mit.edu	37	13	58207511	58207511	+	Silent	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:58207511A>G	ENST00000377918.3	+	1	857	c.831A>G	c.(829-831)gaA>gaG	p.E277E		NM_001040429.2	NP_001035519.1	O14917	PCD17_HUMAN	protocadherin 17	277	Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(30)|liver(2)|lung(54)|ovary(4)|pancreas(2)|prostate(5)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	120		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCAATGGTGAAGTGCTCTACT	0.592000													20	31					0	0	0.007413	0	0
ABCC8	6833	broad.mit.edu	37	11	17418475	17418475	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:17418475G>A	ENST00000302539.4	-	33	4235	c.4110C>T	c.(4108-4110)gcC>gcT	p.A1370A	ABCC8_ENST00000389817.3_Silent_p.A1369A	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	1369	ABC transporter 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	TCTGTCCAGGGGCGATGAGGG	0.617000													95	112					0	0	0.003610	0	0
WSCD2	9671	broad.mit.edu	37	12	108634201	108634201	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:108634201G>A	ENST00000332082.4	+	9	2043	c.1225G>A	c.(1225-1227)Gag>Aag	p.E409K	WSCD2_ENST00000261400.3_Missense_Mutation_p.E409K|WSCD2_ENST00000549903.1_Missense_Mutation_p.E409K|WSCD2_ENST00000547525.1_Missense_Mutation_p.E409K			Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	409						integral to membrane				breast(4)|endometrium(3)|kidney(1)|large_intestine(16)|liver(2)|lung(23)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	57						GAAAGAGATCGAGGCCTTCGA	0.607000													43	95					0	0	0.003214	0	0
ERVW-1	30816	broad.mit.edu	37	7	92098843	92098843	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:92098843C>T	ENST00000493463.2	-	1	1776	c.853G>A	c.(853-855)Gaa>Aaa	p.E285K	AC007566.10_ENST00000427458.1_RNA|ERVW-1_ENST00000604270.1_Intron|ERVW-1_ENST00000603053.1_Missense_Mutation_p.E285K	NM_014590.3	NP_055405.3	Q9UQF0	ENW1_HUMAN		285					syncytium formation	integral to membrane|plasma membrane|virion				endometrium(1)|large_intestine(1)|lung(15)	17						cacatagattctgaagagcca	0.433000													17	26					0	0	0.006122	0	0
GPX5	2880	broad.mit.edu	37	6	28501753	28501753	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:28501753C>T	ENST00000412168.2	+	5	564	c.475C>T	c.(475-477)Ccc>Tcc	p.P159S	GPX5_ENST00000469384.1_3'UTR|GPX5_ENST00000442674.2_3'UTR	NM_001509.2	NP_001500.1	O75715	GPX5_HUMAN	glutathione peroxidase 5 (epididymal androgen-related protein)	159					lipid metabolic process|response to oxidative stress	extracellular region	glutathione peroxidase activity			endometrium(2)|large_intestine(4)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16					Glutathione(DB00143)	CTGTCCTCATCCCTCTGAGAT	0.463000													54	280					0	0	0.003610	0	0
DRC1	92749	broad.mit.edu	37	2	26672939	26672939	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:26672939G>A	ENST00000288710.2	+	12	1659	c.1585G>A	c.(1585-1587)Gat>Aat	p.D529N		NM_145038.2	NP_659475.2			dynein regulatory complex subunit 1 homolog (Chlamydomonas)																		GCTGAGGCTGGATGCCATCTT	0.607000													10	4					0	0	0.006214	0	0
C1R	715	broad.mit.edu	37	12	7242783	7242783	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:7242783T>C	ENST00000542285.1	-	3	439	c.290A>G	c.(289-291)aAc>aGc	p.N97S				P00736	C1R_HUMAN	complement component 1, r subcomponent	98	CUB 1.				complement activation, classical pathway|innate immune response|proteolysis	extracellular region	calcium ion binding|serine-type endopeptidase activity			endometrium(4)|kidney(1)|large_intestine(4)|lung(6)|pancreas(1)	16					Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TCCCGGGGGGTTGCCCAGTGG	0.517000													3	6					0	0	0.000248	0	0
SLC22A25	387601	broad.mit.edu	37	11	62951205	62951205	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:62951205C>T	ENST00000403374.2	-	6	720	c.417G>A	c.(415-417)agG>agA	p.R139R	SLC22A10_ENST00000535888.1_Intron|SLC22A25_ENST00000306494.6_Silent_p.R305R|SLC22A10_ENST00000525620.1_Intron			Q6T423	S22AP_HUMAN	solute carrier family 22, member 25	305					transmembrane transport	integral to membrane				NS(2)|breast(2)|endometrium(4)|kidney(2)|large_intestine(7)|lung(7)|ovary(3)|skin(7)	34						TCATTCCATTCCTGTGTGCAG	0.463000													72	83					0	0	0.003610	0	0
CAMKK1	84254	broad.mit.edu	37	17	3772873	3772873	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:3772873G>C	ENST00000381771.2	-	15	1510	c.1363C>G	c.(1363-1365)Ctt>Gtt	p.L455V	CAMKK1_ENST00000381769.2_Missense_Mutation_p.L444V|CAMKK1_ENST00000158166.5_Missense_Mutation_p.L455V|CAMKK1_ENST00000348335.2_Missense_Mutation_p.L417V			Q8N5S9	KKCC1_HUMAN	calcium/calmodulin-dependent protein kinase kinase 1, alpha	417	Calmodulin-binding (By similarity).				synaptic transmission	cytosol|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)	11				LUAD - Lung adenocarcinoma(2;2.11e-05)|Lung(3;0.0176)		TCCGAAGGAAGGGGCTCCTCC	0.622000													18	24					0	0	0.007413	0	0
UNC5C	8633	broad.mit.edu	37	4	96106277	96106277	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:96106277C>T	ENST00000453304.1	-	13	2555	c.2207G>A	c.(2206-2208)gGc>gAc	p.G736D		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	736					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		GTGGGTGCTGCCTTTAAAATG	0.468000													26	45					0	0	0.005443	0	0
SCN5A	6331	broad.mit.edu	37	3	38622668	38622668	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:38622668G>A	ENST00000413689.1	-	17	3175	c.2982C>T	c.(2980-2982)gcC>gcT	p.A994A	SCN5A_ENST00000425664.1_Silent_p.A994A|SCN5A_ENST00000443581.1_Silent_p.A994A|SCN5A_ENST00000423572.2_Silent_p.A994A|SCN5A_ENST00000449557.2_Silent_p.A994A|SCN5A_ENST00000414099.2_Silent_p.A994A|SCN5A_ENST00000450102.2_Silent_p.A994A|SCN5A_ENST00000451551.2_Silent_p.A994A|SCN5A_ENST00000455624.2_Silent_p.A994A|SCN5A_ENST00000333535.4_Silent_p.A994A	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	994					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GGGCGGCAAGGGCTGCGGGCT	0.687000													4	16					0	0	0.000248	0	0
LRRC37A6P	387646	broad.mit.edu	37	10	27535362	27535362	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:27535362C>T	ENST00000574842.1	+	0	255																											GTTAGTATTTCGGTCACAAAT	0.388000													10	11					0	0	0.006214	0	0
GPR179	440435	broad.mit.edu	37	17	36486596	36486596	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:36486596C>T	ENST00000342292.4	-	11	2876	c.2856G>A	c.(2854-2856)agG>agA	p.R952R		NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	952						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				GAGATAGCATCCTTGGCTCTC	0.627000													9	3					0	0	0.004482	0	0
OR8H3	390152	broad.mit.edu	37	11	55890068	55890068	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:55890068T>A	ENST00000313472.3	+	1	220	c.220T>A	c.(220-222)Tac>Aac	p.Y74N		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	74					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					TGACCTCAGTTACTCAACTGT	0.448000													89	463					0	0	0.003610	0	0
MTHFD1	4522	broad.mit.edu	37	14	64896942	64896942	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:64896942G>A	ENST00000555709.1	+	13	1692	c.1305G>A	c.(1303-1305)atG>atA	p.M435I	CTD-2555O16.2_ENST00000556640.1_RNA|MTHFD1_ENST00000555252.1_Missense_Mutation_p.M415I|MTHFD1_ENST00000216605.7_Missense_Mutation_p.M491I|MTHFD1_ENST00000545908.1_Missense_Mutation_p.M491I	NM_005956.3	NP_005947.3	P11586	C1TC_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase	435	Formyltetrahydrofolate synthetase.				folic acid metabolic process|folic acid-containing compound biosynthetic process|histidine biosynthetic process|methionine biosynthetic process|one-carbon metabolic process|purine nucleotide biosynthetic process	cytosol|mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase|methylenetetrahydrofolate dehydrogenase (NADP+) activity|protein binding			endometrium(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|pancreas(1)|prostate(2)|skin(2)	30				OV - Ovarian serous cystadenocarcinoma(108;8.7e-12)|all cancers(60;3.29e-11)|BRCA - Breast invasive adenocarcinoma(234;0.0488)	NADH(DB00157)|Tetrahydrofolic acid(DB00116)	TCATTCCTATGGAAGAGGTAA	0.507000											OREG0022729	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	61	65					0	0	0.003610	0	0
SLC11A2	4891	broad.mit.edu	37	12	51384701	51384701	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:51384701G>A	ENST00000394904.3	-	15	1588	c.1539C>T	c.(1537-1539)gtC>gtT	p.V513V	SLC11A2_ENST00000546743.1_Silent_p.V405V|SLC11A2_ENST00000545993.2_Silent_p.V480V|SLC11A2_ENST00000541174.2_Silent_p.V484V|SLC11A2_ENST00000547688.1_Silent_p.V513V|SLC11A2_ENST00000547198.1_Silent_p.V484V|SLC11A2_ENST00000262052.5_Silent_p.V484V|SLC11A2_ENST00000262051.7_Silent_p.V484V	NM_001174125.1	NP_001167596.1	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2	484					activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			breast(2)|cervix(1)|endometrium(3)|kidney(16)|large_intestine(4)|lung(9)|upper_aerodigestive_tract(1)	36						AGATGATAAGGACCAAGATTC	0.468000													12	25					0	0	0.001855	0	0
CDCP1	64866	broad.mit.edu	37	3	45136996	45136996	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:45136996G>A	ENST00000296129.1	-	5	1223	c.1089C>T	c.(1087-1089)ccC>ccT	p.P363P		NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	363						extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TCTGTTTGACGGGCCGTGGCT	0.498000													22	47					0	0	0.001882	0	0
ANKFN1	162282	broad.mit.edu	37	17	54450167	54450167	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:54450167C>T	ENST00000566473.2	+	6	771	c.771C>T	c.(769-771)ctC>ctT	p.L257L	ANKFN1_ENST00000318698.2_Silent_p.L257L			Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain containing 1	257								p.L257L(1)		NS(1)|breast(1)|cervix(2)|endometrium(4)|kidney(4)|large_intestine(11)|lung(27)|ovary(1)|prostate(1)|skin(1)	53						GGTATCGGCTCTACAGACGCA	0.483000													130	90					0	0	0.003610	0	0
MIA3	375056	broad.mit.edu	37	1	222798135	222798135	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:222798135C>T	ENST00000344922.5	+	3	318	c.293C>T	c.(292-294)cCa>cTa	p.P98L	MIA3_ENST00000344507.1_Missense_Mutation_p.P98L|MIA3_ENST00000470521.1_3'UTR|MIA3_ENST00000344441.6_Missense_Mutation_p.P98L	NM_198551.2	NP_940953.2	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	98	SH3.				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			breast(5)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(15)|lung(37)|ovary(5)|pancreas(2)|prostate(2)|skin(2)|stomach(4)|urinary_tract(1)	80				GBM - Glioblastoma multiforme(131;0.0199)		GGATATTTTCCAAAAGATTTA	0.353000													359	207					0	0	0.003610	0	0
DNAH17	8632	broad.mit.edu	37	17	76503785	76503785	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:76503785C>T	ENST00000389840.5	-	28	4451	c.4327G>A	c.(4327-4329)Gag>Aag	p.E1443K	DNAH17_ENST00000585328.1_Missense_Mutation_p.E1444K					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TCCAGCGTCTCCACCAGCACC	0.592000													3	9					0	0	0.000248	0	0
ARID1A	8289	broad.mit.edu	37	1	27088718	27088718	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:27088718C>T	ENST00000324856.7	+	7	2698	c.2327C>T	c.(2326-2328)cCt>cTt	p.P776L	ARID1A_ENST00000457599.2_Missense_Mutation_p.P776L|ARID1A_ENST00000374152.2_Missense_Mutation_p.P393L	NM_006015.4	NP_006006.3	O14497	ARI1A_HUMAN	AT rich interactive domain 1A (SWI-like)	776				P -> L (in Ref. 1; AAG33967, 5; AAG17549 and 7; BAA23269).	androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding		ARID1A/MAST2_ENST00000361297(2)	NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(13)|central_nervous_system(6)|cervix(2)|endometrium(56)|haematopoietic_and_lymphoid_tissue(8)|kidney(10)|large_intestine(41)|liver(31)|lung(34)|ovary(130)|pancreas(18)|prostate(8)|skin(9)|stomach(14)|upper_aerodigestive_tract(4)|urinary_tract(24)	411		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCGCGTCAGCCTTCCGGAGGA	0.572000			"""Mis, N, F, S, D"""		"""clear cell ovarian carcinoma, RCC"""								28	66					0	0	0.005443	0	0
MIR596	693181	broad.mit.edu	37	8	1765429	1765429	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:1765429C>T	ENST00000385091.1	+	0	33					NR_030326.1																						CCCGGCTCCTCGGGAACCTGC	0.622000													9	23					0	0	0.006214	0	0
HARBI1	283254	broad.mit.edu	37	11	46625266	46625266	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:46625266G>A	ENST00000326737.3	-	3	1111	c.864C>T	c.(862-864)tcC>tcT	p.S288S		NM_173811.3	NP_776172.1	Q96MB7	HARB1_HUMAN	harbinger transposase derived 1	288						cytoplasm|nucleus	metal ion binding|nuclease activity			large_intestine(1)|prostate(1)|upper_aerodigestive_tract(1)	3						TGATATGGCTGGATTTCTCTG	0.542000													13	13					0	0	0.001368	0	0
PRDM11	56981	broad.mit.edu	37	11	45226312	45226312	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:45226312C>T	ENST00000263765.4	+	6	888	c.639C>T	c.(637-639)acC>acT	p.T213T	PRDM11_ENST00000530656.1_Silent_p.T213T|PRDM11_ENST00000424263.2_Silent_p.T179T|PRDM11_ENST00000528980.1_3'UTR			Q9NQV5	PRD11_HUMAN	PR domain containing 11	213	SET.									endometrium(3)|kidney(3)|large_intestine(5)|lung(10)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	26						CAGACGAGACCAAAGCCAACT	0.542000													25	37					0	0	0.001786	0	0
SI	6476	broad.mit.edu	37	3	164785275	164785275	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:164785275G>A	ENST00000264382.3	-	6	550	c.488C>T	c.(487-489)aCt>aTt	p.T163I		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	163	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ATTTGGATCAGTAATCTGGAA	0.313000										HNSCC(35;0.089)			24	81					0	0	0.005443	0	0
AMZ1	155185	broad.mit.edu	37	7	2752035	2752035	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2752035G>A	ENST00000312371.4	+	7	1388	c.1020G>A	c.(1018-1020)tgG>tgA	p.W340*	AMZ1_ENST00000489665.1_Intron|AMZ1_ENST00000407112.1_Missense_Mutation_p.G284R	NM_133463.1	NP_597720.1	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	340							metallopeptidase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	16		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		CGTCAGTGTGGGAGGACACCC	0.667000													4	34					0	0	0.000248	0	0
TNFRSF21	27242	broad.mit.edu	37	6	47202494	47202494	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:47202494G>A	ENST00000296861.2	-	5	2043	c.1650C>T	c.(1648-1650)ttC>ttT	p.F550F		NM_014452.3	NP_055267.1	O75509	TNR21_HUMAN	tumor necrosis factor receptor superfamily, member 21	550					cellular lipid metabolic process	cytoplasm|integral to membrane	protein binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(6)|lung(7)|pancreas(1)|skin(2)	21			Lung(136;0.189)			ACTCATCCACGAAGAAGCCCT	0.597000													4	22					0	0	0.000602	0	0
MYH8	4626	broad.mit.edu	37	17	10300303	10300303	+	Splice_Site	SNP	C	C	T	rs143515663		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:10300303C>T	ENST00000403437.2	-	31	4273	c.4178_splice	c.e31-1	p.K1393_splice	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	1393					muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CCAACTTTTTCCTGAAAAGTT	0.478000									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				8	18					0	0	0.003080	0	0
NUP210L	91181	broad.mit.edu	37	1	154072525	154072525	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:154072525A>C	ENST00000368559.3	-	14	1985	c.1914T>G	c.(1912-1914)tgT>tgG	p.C638W	NUP210L_ENST00000271854.3_Missense_Mutation_p.C638W	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	638						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			AGTACTTGTCACATTCATTCA	0.403000													56	184					0	0	0.003610	0	0
TRIM31	11074	broad.mit.edu	37	6	30080314	30080314	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:30080314C>T	ENST00000376734.3	-	2	394	c.269G>A	c.(268-270)aGg>aAg	p.R90K	TRIM31_ENST00000540829.1_Missense_Mutation_p.R90K|TRIM31-AS1_ENST00000440874.1_RNA	NM_007028.3	NP_008959.3	Q9BZY9	TRI31_HUMAN	tripartite motif containing 31	90						mitochondrion	ligase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(2)|skin(2)	15						AGCCTCTTTCCTTTTGGACTG	0.493000													28	136					0	0	0.007291	0	0
HAS3	3038	broad.mit.edu	37	16	69143862	69143862	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:69143862G>A	ENST00000306560.1	+	2	720	c.564G>A	c.(562-564)caG>caA	p.Q188Q	HAS3_ENST00000569188.1_Silent_p.Q188Q|HAS3_ENST00000219322.3_Silent_p.Q188Q	NM_005329.2	NP_005320.2	O00219	HAS3_HUMAN	hyaluronan synthase 3	188					carbohydrate metabolic process	integral to plasma membrane	hyaluronan synthase activity			cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|urinary_tract(2)	16		Ovarian(137;0.101)		OV - Ovarian serous cystadenocarcinoma(108;0.0694)		GCATCATGCAGAAGTGGGGAG	0.642000													13	25					0	0	0.001855	0	0
C1QTNF1	114897	broad.mit.edu	37	17	77043683	77043683	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:77043683G>A	ENST00000339142.2	+	5	914	c.359G>A	c.(358-360)gGg>gAg	p.G120E	C1QTNF1_ENST00000580474.1_Missense_Mutation_p.G120E|C1QTNF1_ENST00000578229.1_Missense_Mutation_p.G38E|C1QTNF1_ENST00000582625.1_3'UTR|C1QTNF1_ENST00000583904.1_Missense_Mutation_p.G120E|C1QTNF1_ENST00000581774.1_Missense_Mutation_p.G120E|C1QTNF1_ENST00000580454.1_Missense_Mutation_p.G120E|C1QTNF1_ENST00000311661.4_Missense_Mutation_p.G38E|C1QTNF1_ENST00000579760.1_Missense_Mutation_p.G120E|C1QTNF1_ENST00000354124.3_Missense_Mutation_p.G130E|C1QTNF1_ENST00000392445.2_Missense_Mutation_p.G120E	NM_198593.3	NP_940995.1	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	120	Collagen-like.					collagen				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(2)	14			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			GGCTCAGCAGGGGCCAGGGGC	0.627000													56	37					0	0	0.003610	0	0
KIAA1109	84162	broad.mit.edu	37	4	123265596	123265596	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:123265596C>T	ENST00000264501.4	+	74	12986	c.12613C>T	c.(12613-12615)Ctt>Ttt	p.L4205F	KIAA1109_ENST00000388738.3_Missense_Mutation_p.L4205F			Q2LD37	K1109_HUMAN	KIAA1109	4205					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				breast(7)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(6)|large_intestine(33)|liver(4)|lung(74)|ovary(9)|pancreas(1)|prostate(5)|skin(6)|upper_aerodigestive_tract(6)|urinary_tract(3)	172						CAGTATAAACCTTGAGTTTGT	0.413000													37	35					0	0	0.004878	0	0
ZNF331	55422	broad.mit.edu	37	19	54080919	54080919	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54080919C>T	ENST00000253144.9	+	7	2438	c.1105C>T	c.(1105-1107)Cac>Tac	p.H369Y	ZNF331_ENST00000449416.1_Missense_Mutation_p.H369Y|ZNF331_ENST00000512387.1_Missense_Mutation_p.H369Y|ZNF331_ENST00000511593.2_Missense_Mutation_p.H369Y|ZNF331_ENST00000411977.2_Missense_Mutation_p.H369Y|ZNF331_ENST00000513999.1_Missense_Mutation_p.H369Y|ZNF331_ENST00000513265.1_3'UTR|ZNF331_ENST00000511154.1_Missense_Mutation_p.H369Y	NM_001253801.1|NM_018555.5	NP_001240730.1|NP_061025.5	Q9NQX6	ZN331_HUMAN	zinc finger protein 331	369					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	10				GBM - Glioblastoma multiforme(134;0.00555)		TTGTGGCTATCACCTCACTCA	0.507000			T	?	follicular thyroid adenoma								7	31					0	0	0.003080	0	0
DYNC1I2	1781	broad.mit.edu	37	2	172563854	172563854	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:172563854G>A	ENST00000534253.2	+	5	470	c.302G>A	c.(301-303)aGc>aAc	p.S101N	DYNC1I2_ENST00000410079.3_Missense_Mutation_p.S113N|DYNC1I2_ENST00000358002.6_Missense_Mutation_p.S113N|DYNC1I2_ENST00000409773.1_Missense_Mutation_p.S101N|DYNC1I2_ENST00000409317.1_Missense_Mutation_p.S95N|AC068039.1_ENST00000598148.1_Intron|DYNC1I2_ENST00000263811.4_Missense_Mutation_p.S95N|DYNC1I2_ENST00000508530.1_Missense_Mutation_p.S95N|DYNC1I2_ENST00000397119.3_Missense_Mutation_p.S101N|DYNC1I2_ENST00000340296.4_Missense_Mutation_p.S95N|DYNC1I2_ENST00000409197.1_Missense_Mutation_p.S95N|DYNC1I2_ENST00000409453.1_Missense_Mutation_p.S101N			Q13409	DC1I2_HUMAN	dynein, cytoplasmic 1, intermediate chain 2	101					G2/M transition of mitotic cell cycle|interspecies interaction between organisms|microtubule-based movement|transport	centrosome|cytosol|dynein complex|microtubule|vesicle	microtubule motor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|ovary(1)	15			OV - Ovarian serous cystadenocarcinoma(117;0.198)			GAAGCTGGAAGCCAAGACTCT	0.438000													21	37					0	0	0.003330	0	0
OTUD7A	161725	broad.mit.edu	37	15	31819489	31819489	+	Silent	SNP	C	C	T	rs142018701		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:31819489C>T	ENST00000382902.1	-	5	767	c.675G>A	c.(673-675)cgG>cgA	p.R225R	OTUD7A_ENST00000307050.4_Silent_p.R225R			Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	225	Catalytic (By similarity).|OTU.|TRAF-binding (By similarity).					cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			endometrium(7)|large_intestine(4)|lung(11)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	30		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		ACACCAGGTCCCGGTCGTGAA	0.557000													15	35					0	0	0.004007	0	0
POTEH	23784	broad.mit.edu	37	22	16287309	16287309	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:16287309C>T	ENST00000343518.6	-	1	628	c.577G>A	c.(577-579)Gat>Aat	p.D193N		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	193										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						ACGATGAGATCCTTTCTGGGG	0.552000													6	100					0	0	0.004007	0	0
PDE4D	5144	broad.mit.edu	37	5	58511729	58511729	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:58511729G>A	ENST00000340635.6	-	2	696	c.521C>T	c.(520-522)tCc>tTc	p.S174F	PDE4D_ENST00000502575.1_Missense_Mutation_p.S110F|PDE4D_ENST00000360047.5_Missense_Mutation_p.S38F|PDE4D_ENST00000503258.1_Missense_Mutation_p.S44F|PDE4D_ENST00000405755.2_Missense_Mutation_p.S52F|PDE4D_ENST00000546160.1_Missense_Mutation_p.S113F|PDE4D_ENST00000502484.2_Missense_Mutation_p.S113F|PDE4D_ENST00000503947.1_5'UTR|PDE4D_ENST00000507116.1_Missense_Mutation_p.S110F	NM_001104631.1	NP_001098101.1	Q08499	PDE4D_HUMAN	phosphodiesterase 4D, cAMP-specific	174					signal transduction	cytosol|insoluble fraction|membrane|microtubule organizing center|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|pancreas(1)	15		all_cancers(5;6.5e-58)|all_epithelial(5;1.75e-57)|all_lung(5;6.84e-18)|Lung NSC(5;1.29e-17)|Melanoma(5;0.00168)|Prostate(74;0.00234)|Colorectal(97;0.00629)|Ovarian(174;0.00832)|Breast(144;0.00996)|all_hematologic(6;0.0344)|Hepatocellular(6;0.0742)|Esophageal squamous(6;0.0954)		Epithelial(2;2.6e-55)|all cancers(2;2.66e-49)|OV - Ovarian serous cystadenocarcinoma(10;1.48e-39)|Colorectal(2;8.29e-08)|Lung(2;4.47e-07)|STAD - Stomach adenocarcinoma(2;1.11e-05)|COAD - Colon adenocarcinoma(2;0.00012)|LUSC - Lung squamous cell carcinoma(2;0.000775)|LUAD - Lung adenocarcinoma(3;0.0173)|READ - Rectum adenocarcinoma(2;0.0276)	Adenosine monophosphate(DB00131)|Dyphylline(DB00651)	AATTAGCCCGGATCCTGGGCT	0.498000													8	30					0	0	0.003080	0	0
SNX9	51429	broad.mit.edu	37	6	158342637	158342637	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:158342637C>T	ENST00000392185.3	+	10	1195	c.1024C>T	c.(1024-1026)Cca>Tca	p.P342S		NM_016224.3	NP_057308.1	Q9Y5X1	SNX9_HUMAN	sorting nexin 9	342	PX.				cell communication|intracellular protein transport|lipid tube assembly|positive regulation of GTPase activity|positive regulation of protein oligomerization|receptor-mediated endocytosis	clathrin-coated vesicle|cytoplasmic vesicle membrane|extrinsic to internal side of plasma membrane|ruffle|trans-Golgi network	1-phosphatidylinositol binding|protein homodimerization activity|ubiquitin protein ligase binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(10)|skin(1)|upper_aerodigestive_tract(1)	20		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.167)		OV - Ovarian serous cystadenocarcinoma(65;8.06e-18)|BRCA - Breast invasive adenocarcinoma(81;4.48e-05)		GTGTCGCCATCCAGTAATCTC	0.443000													24	27					0	0	0.007291	0	0
OR11A1	26531	broad.mit.edu	37	6	29395053	29395053	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:29395053G>A	ENST00000377149.1	-	5	838	c.366C>T	c.(364-366)gaC>gaT	p.D122D	OR5V1_ENST00000377154.1_Intron|OR11A1_ENST00000377148.1_Silent_p.D122D|OR11A1_ENST00000377147.2_Silent_p.D122D			Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A, member 1	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|large_intestine(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	19						CCAGGTAGCGGTCATATGCCA	0.537000													18	140					0	0	0.004990	0	0
TRHDE	29953	broad.mit.edu	37	12	72956740	72956740	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:72956740A>T	ENST00000261180.4	+	9	1923	c.1827A>T	c.(1825-1827)gaA>gaT	p.E609D	TRHDE_ENST00000549138.1_3'UTR	NM_013381.2	NP_037513.1	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	609					cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(38)|ovary(2)|skin(4)|soft_tissue(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	79						CAACAGCAGAAAATAGAATAA	0.328000													28	106					0	0	0.005443	0	0
CCDC171	203238	broad.mit.edu	37	9	15744360	15744360	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:15744360C>T	ENST00000380701.3	+	17	2467	c.2139C>T	c.(2137-2139)ttC>ttT	p.F713F	CCDC171_ENST00000297641.3_Silent_p.F713F	NM_173550.2	NP_775821.2	Q6TFL3	CI093_HUMAN	coiled-coil domain containing 171	713																	ATTCGCACTTCAAAAAACTGT	0.393000													34	72					0	0	0.002445	0	0
HTR1F	3355	broad.mit.edu	37	3	88040541	88040541	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:88040541G>A	ENST00000319595.4	+	1	696	c.642G>A	c.(640-642)aaG>aaA	p.K214K		NM_000866.3	NP_000857.1	P30939	5HT1F_HUMAN	5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled	214					G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane	serotonin binding|serotonin receptor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	25	all_cancers(8;0.147)	Lung NSC(201;0.0283)		LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00664)	Eletriptan(DB00216)|Naratriptan(DB00952)|Rizatriptan(DB00953)|Sumatriptan(DB00669)|Zolmitriptan(DB00315)	TATACCACAAGAGACAAGCAA	0.403000													16	55					0	0	0.004007	0	0
PRSS35	167681	broad.mit.edu	37	6	84234162	84234162	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:84234162C>T	ENST00000536636.1	+	3	1347	c.1002C>T	c.(1000-1002)ctC>ctT	p.L334L	PRSS35_ENST00000369700.3_Silent_p.L334L	NM_001170423.1	NP_001163894.1	Q8N3Z0	PRS35_HUMAN	protease, serine, 35	334	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			breast(2)|endometrium(2)|large_intestine(12)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	32		all_cancers(76;0.000113)|Acute lymphoblastic leukemia(125;1.09e-08)|all_hematologic(105;3.12e-05)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0768)		CCAATGATCTCCTTTACCAAT	0.473000													37	39					0	0	0.006999	0	0
PRKD2	25865	broad.mit.edu	37	19	47181848	47181848	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:47181848G>A	ENST00000433867.1	-	17	2620	c.2143C>T	c.(2143-2145)Ccg>Tcg	p.P715S	PRKD2_ENST00000595515.1_Missense_Mutation_p.P715S|PRKD2_ENST00000291281.4_Missense_Mutation_p.P715S|PRKD2_ENST00000601806.1_Missense_Mutation_p.P558S|PRKD2_ENST00000600194.1_Missense_Mutation_p.P558S|PRKD2_ENST00000593492.1_5'UTR	NM_001079880.1|NM_001079881.1|NM_016457.4	NP_001073349.1|NP_001073350.1|NP_057541.2	Q9BZL6	KPCD2_HUMAN	protein kinase D2	715	Protein kinase.				cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(13)|ovary(2)|prostate(2)|skin(1)|stomach(2)|urinary_tract(1)	41		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		AGGTAGGCCGGCGTGCCCACC	0.627000													24	29					0	0	0.002780	0	0
RIN2	54453	broad.mit.edu	37	20	19956093	19956093	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:19956093C>T	ENST00000255006.6	+	8	1720	c.1571C>T	c.(1570-1572)cCc>cTc	p.P524L	RIN2_ENST00000440354.2_Intron|RIN2_ENST00000484638.1_3'UTR	NM_001242581.1|NM_018993.3	NP_001229510.1|NP_061866.1	Q8WYP3	RIN2_HUMAN	Ras and Rab interactor 2	475					endocytosis|small GTPase mediated signal transduction	cytoplasm	GTPase activator activity|Rab guanyl-nucleotide exchange factor activity			autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(4)|lung(11)|ovary(1)|prostate(1)|urinary_tract(2)	27						ACCATGGCGCCCCCCATCAAG	0.587000													12	56					0	0	0.001368	0	0
COL6A2	1292	broad.mit.edu	37	21	47551942	47551942	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:47551942G>A	ENST00000300527.4	+	28	2640	c.2536G>A	c.(2536-2538)Gag>Aag	p.E846K		NM_001849.3	NP_001840.3	P12110	CO6A2_HUMAN	collagen, type VI, alpha 2	846	Nonhelical region.|VWFA 3.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			NS(1)|breast(1)|central_nervous_system(7)|endometrium(7)|kidney(5)|liver(1)|lung(15)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	43	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		GCGGCTGGGTGAGCAGAACTT	0.706000													6	5					0	0	0.001168	0	0
VPS8	23355	broad.mit.edu	37	3	184632796	184632796	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:184632796C>T	ENST00000287546.4	+	26	2388	c.2217C>T	c.(2215-2217)ccC>ccT	p.P739P	VPS8_ENST00000437079.3_Silent_p.P739P|VPS8_ENST00000446204.2_Silent_p.P647P|VPS8_ENST00000436792.2_Silent_p.P737P	NM_015303.3	NP_056118.2	Q8N3P4	VPS8_HUMAN	vacuolar protein sorting 8 homolog (S. cerevisiae)	739							zinc ion binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(11)|lung(19)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	54	all_cancers(143;2.51e-11)|Ovarian(172;0.0339)|Breast(254;0.247)		Epithelial(37;1.02e-33)|OV - Ovarian serous cystadenocarcinoma(80;4.81e-22)			GTGCCTATCCCCTTGGTGACA	0.428000													19	82					0	0	0.001882	0	0
IL7R	3575	broad.mit.edu	37	5	35876163	35876163	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:35876163G>A	ENST00000303115.3	+	8	1084	c.955G>A	c.(955-957)Gaa>Aaa	p.E319K	IL7R_ENST00000343305.4_3'UTR	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	319					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			AGCTAGAGATGAAGTGGAAGG	0.453000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						13	42					0	0	0.001368	0	0
PFKFB2	5208	broad.mit.edu	37	1	207252345	207252345	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:207252345C>T	ENST00000367079.2	+	15	1470	c.1397C>T	c.(1396-1398)tCc>tTc	p.S466F	PFKFB2_ENST00000411990.2_Missense_Mutation_p.S368F|PFKFB2_ENST00000541914.1_Missense_Mutation_p.S259F|PFKFB2_ENST00000473310.1_3'UTR	NM_001018053.1	NP_001018063.1	O60825	F262_HUMAN	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	0	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(3)|liver(1)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	20	Prostate(682;0.19)					TCCGCAGCGTCCCTCATGTTG	0.552000													60	200					0	0	0.003610	0	0
PGC	5225	broad.mit.edu	37	6	41710162	41710162	+	Silent	SNP	G	G	A	rs146180846	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:41710162G>A	ENST00000373025.3	-	5	575	c.513C>T	c.(511-513)ttC>ttT	p.F171F	PGC_ENST00000425343.2_Silent_p.F171F	NM_002630.3	NP_002621.1	P20142	PEPC_HUMAN	progastricsin (pepsinogen C)	171					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity			endometrium(3)|kidney(1)|large_intestine(5)|lung(6)|skin(1)	16	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			GCGCATAGACGAAGTTGGTAC	0.592000													20	83					0	0	0.001523	0	0
TTN	7273	broad.mit.edu	37	2	179477031	179477031	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:179477031C>T	ENST00000589042.1	-	266	50445	c.50221G>A	c.(50221-50223)Gac>Aac	p.D16741N	TTN-AS1_ENST00000589907.1_RNA|TTN_ENST00000359218.5_Missense_Mutation_p.D7801N|TTN-AS1_ENST00000589487.1_RNA|TTN-AS1_ENST00000589234.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.D7868N|TTN_ENST00000591111.1_Missense_Mutation_p.D15100N|TTN_ENST00000460472.2_Missense_Mutation_p.D7676N|TTN_ENST00000342992.6_Missense_Mutation_p.D14173N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	15100	Ig-like 101.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGCACAGAGTCCTCAATTTCG	0.448000													11	13					0	0	0.000673	0	0
ZNF534	147658	broad.mit.edu	37	19	52941587	52941587	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:52941587C>T	ENST00000332323.6	+	4	974	c.913C>T	c.(913-915)Cat>Tat	p.H305Y	ZNF534_ENST00000301085.4_Intron|ZNF534_ENST00000432303.2_Intron|ZNF534_ENST00000433050.1_Missense_Mutation_p.H292Y	NM_001143939.1	NP_001137411.1	Q76KX8	ZN534_HUMAN	zinc finger protein 534	305					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|lung(1)|prostate(1)|skin(1)	4						TAGGAAAATTCATACTGGAGA	0.393000													11	14					0	0	0.000978	0	0
ADCY6	112	broad.mit.edu	37	12	49177038	49177038	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:49177038G>A	ENST00000307885.4	-	1	874	c.180C>T	c.(178-180)ccC>ccT	p.P60P	ADCY6_ENST00000550422.1_Silent_p.P60P|ADCY6_ENST00000357869.3_Silent_p.P60P	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	60					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						GGCACCGAGGGGGGCCCGCAG	0.721000													7	17					0	0	0.001984	0	0
HSPG2	3339	broad.mit.edu	37	1	22173091	22173091	+	Splice_Site	SNP	G	G	A	rs141870522		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:22173091G>A	ENST00000374695.3	-	63	8245	c.8164_splice	c.e63-1	p.A2722_splice	HSPG2_ENST00000430507.1_3'UTR	NM_005529.5	NP_005520.4	P98160	PGBM_HUMAN	heparan sulfate proteoglycan 2	2722	Ig-like C2-type 12.				angiogenesis|cell adhesion|lipid metabolic process|lipoprotein metabolic process	basement membrane|extracellular space|plasma membrane	protein C-terminus binding			breast(6)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(15)|liver(1)|lung(44)|ovary(10)|pancreas(1)|prostate(10)|skin(9)|upper_aerodigestive_tract(3)|urinary_tract(3)	127		Colorectal(325;3.46e-05)|all_lung(284;7.93e-05)|Lung NSC(340;8.71e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0498)|OV - Ovarian serous cystadenocarcinoma(117;1.14e-26)|Colorectal(126;4.18e-07)|COAD - Colon adenocarcinoma(152;1.82e-05)|GBM - Glioblastoma multiforme(114;3.13e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000756)|STAD - Stomach adenocarcinoma(196;0.00656)|KIRC - Kidney renal clear cell carcinoma(1967;0.00942)|READ - Rectum adenocarcinoma(331;0.0721)|Lung(427;0.223)	Becaplermin(DB00102)|Palifermin(DB00039)	AGCTGCCAGGGGCTGGGGGAA	0.597000													18	42					0	0	0.002299	0	0
DOCK3	1795	broad.mit.edu	37	3	51349912	51349912	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:51349912G>A	ENST00000266037.9	+	30	3122	c.3099G>A	c.(3097-3099)tgG>tgA	p.W1033*		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1033						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TCTAGGTGTGGAATTCTTACT	0.378000													20	45					0	0	0.001523	0	0
MORC1	27136	broad.mit.edu	37	3	108682428	108682428	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:108682428C>T	ENST00000232603.5	-	27	2714	c.2632G>A	c.(2632-2634)Gaa>Aaa	p.E878K	MORC1_ENST00000483760.1_Missense_Mutation_p.E857K	NM_014429.3	NP_055244.3	Q86VD1	MORC1_HUMAN	MORC family CW-type zinc finger 1	878					cell differentiation|multicellular organismal development|spermatogenesis	nucleus	ATP binding|zinc ion binding			breast(7)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(47)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	105						ATTTTTTTTTCATATTGGACC	0.279000													17	34					0	0	0.001216	0	0
OR5H2	79310	broad.mit.edu	37	3	98002321	98002321	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:98002321C>T	ENST00000355273.2	+	1	590	c.590C>T	c.(589-591)cCt>cTt	p.P197L	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005482.1	NP_001005482.1	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H, member 2	197					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.P197H(1)		breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						TGTACTGACCCTTCTATTAAT	0.308000													25	61					0	0	0.003330	0	0
KCNH4	23415	broad.mit.edu	37	17	40330388	40330388	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:40330388C>T	ENST00000264661.3	-	3	750	c.418G>A	c.(418-420)Gga>Aga	p.G140R	KCNH4_ENST00000607371.1_Missense_Mutation_p.G140R	NM_012285.2	NP_036417.1	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 4	140	PAC.				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(15)|skin(2)|urinary_tract(1)	32		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		GGGCCAAGTCCTGGGCTTCCA	0.562000													24	10					0	0	0.004656	0	0
CYP27B1	1594	broad.mit.edu	37	12	58158686	58158686	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:58158686C>T	ENST00000228606.4	-	5	1023	c.814G>A	c.(814-816)Gag>Aag	p.E272K		NM_000785.3	NP_000776.1	O15528	CP27B_HUMAN	cytochrome P450, family 27, subfamily B, polypeptide 1	272					bone mineralization|calcium ion homeostasis|calcium ion transport|decidualization|G1 to G0 transition|hormone biosynthetic process|negative regulation of calcidiol 1-monooxygenase activity|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of keratinocyte differentiation|positive regulation of vitamin D 24-hydroxylase activity|positive regulation of vitamin D receptor signaling pathway|regulation of bone mineralization|response to estrogen stimulus|response to interferon-gamma|response to lipopolysaccharide|response to tumor necrosis factor|response to vitamin D|vitamin D biosynthetic process|xenobiotic metabolic process	mitochondrial outer membrane	calcidiol 1-monooxygenase activity|electron carrier activity|heme binding			central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(1)|urinary_tract(1)	15	all_cancers(7;8.09e-80)|Lung NSC(6;2.26e-27)|all_lung(6;1.99e-25)|all_epithelial(6;3.62e-18)|Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)		GBM - Glioblastoma multiforme(5;1.97e-113)|all cancers(5;1.54e-78)|BRCA - Breast invasive adenocarcinoma(9;0.0294)		Calcidiol(DB00146)|Calcitriol(DB00136)|Ergocalciferol(DB00153)	GCCTCTGCCTCTCGCCGCTCC	0.617000													23	64					0	0	0.003330	0	0
DES	1674	broad.mit.edu	37	2	220285356	220285356	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:220285356C>T	ENST00000373960.3	+	4	961	c.875C>T	c.(874-876)gCt>gTt	p.A292V		NM_001927.3	NP_001918.3	P17661	DESM_HUMAN	desmin	292	Linker 2.|Rod.				cytoskeleton organization|muscle filament sliding|regulation of heart contraction	cytosol|Z disc	protein binding|structural constituent of cytoskeleton			breast(1)|central_nervous_system(2)|endometrium(2)|large_intestine(2)|lung(10)|skin(1)	18		Renal(207;0.0183)		Epithelial(149;5.25e-07)|all cancers(144;0.000103)|Lung(261;0.00533)|LUSC - Lung squamous cell carcinoma(224;0.008)		ATTTCTGAAGCTGAGGAGTGG	0.592000													12	23					0	0	0.001855	0	0
ADAMTS20	80070	broad.mit.edu	37	12	43858432	43858432	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:43858432G>A	ENST00000389420.3	-	10	1470	c.1471C>T	c.(1471-1473)Ctt>Ttt	p.L491F	ADAMTS20_ENST00000553158.1_Missense_Mutation_p.L491F	NM_025003.3	NP_079279.3	P59510	ATS20_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 20	491	Disintegrin.					proteinaceous extracellular matrix	zinc ion binding			breast(1)|central_nervous_system(6)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(43)|ovary(4)|pancreas(3)|prostate(5)|skin(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	95	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CCAAACGCAAGCTCACACTGC	0.373000													36	89					0	0	0.006230	0	0
ITGAX	3687	broad.mit.edu	37	16	31373954	31373954	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:31373954C>T	ENST00000268296.4	+	12	1360	c.1239C>T	c.(1237-1239)ctC>ctT	p.L413L	ITGAX_ENST00000562522.1_Silent_p.L413L	NM_000887.3	NP_000878.2	P20702	ITAX_HUMAN	integrin, alpha X (complement component 3 receptor 4 subunit)	413					blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(42)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	77						AGCTGGCCCTCTGGAAAGGGG	0.672000													3	7					0	0	0.004672	0	0
SPTBN1	6711	broad.mit.edu	37	2	54872557	54872557	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:54872557C>T	ENST00000333896.5	+	20	4807	c.4422C>T	c.(4420-4422)atC>atT	p.I1474I	SPTBN1_ENST00000356805.4_Silent_p.I1487I	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	1487					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			CCAAAGAGATCCATCAGTTCA	0.552000													16	44					0	0	0.003163	0	0
SEC24C	9632	broad.mit.edu	37	10	75529739	75529739	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:75529739C>T	ENST00000339365.2	+	21	2990	c.2828C>T	c.(2827-2829)aCc>aTc	p.T943I	SEC24C_ENST00000411652.2_Missense_Mutation_p.T824I|SEC24C_ENST00000496827.1_3'UTR|SEC24C_ENST00000345254.4_Missense_Mutation_p.T943I|SEC24C_ENST00000535742.1_Missense_Mutation_p.T191I|SEC24C_ENST00000540668.1_Missense_Mutation_p.T191I	NM_004922.3	NP_004913.2	P53992	SC24C_HUMAN	SEC24 family member C	943					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(12)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	Prostate(51;0.0112)					GTGACTGAGACCAATGTCTTC	0.512000													51	81					0	0	0.003610	0	0
CFTR	1080	broad.mit.edu	37	7	117182160	117182160	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:117182160G>A	ENST00000003084.6	+	9	1339	c.1207G>A	c.(1207-1209)Gag>Aag	p.E403K	CFTR_ENST00000454343.1_Missense_Mutation_p.E403K	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	403					respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	CTTCTGGGAGGAGGTCAGAAT	0.313000									Cystic Fibrosis				12	19					0	0	0.001855	0	0
FPR1	2357	broad.mit.edu	37	19	52249517	52249517	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:52249517G>A	ENST00000595042.1	-	3	872	c.731C>T	c.(730-732)tCc>tTc	p.S244F	FPR1_ENST00000304748.4_Missense_Mutation_p.S244F	NM_001193306.1	NP_001180235.1	P21462	FPR1_HUMAN	formyl peptide receptor 1	244					activation of MAPK activity|cellular component movement|chemotaxis|G-protein signaling, coupled to cAMP nucleotide second messenger|nitric oxide mediated signal transduction	endosome|integral to membrane|plasma membrane	N-formyl peptide receptor activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|stomach(3)	20		all_neural(266;0.0189)|Medulloblastoma(540;0.146)		GBM - Glioblastoma multiforme(134;0.00106)|OV - Ovarian serous cystadenocarcinoma(262;0.018)	Nedocromil(DB00716)	TGCGACAAAGGAGAGGACCCG	0.507000													19	19					0	0	0.001216	0	0
CACNA1A	773	broad.mit.edu	37	19	13446673	13446673	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:13446673G>A	ENST00000360228.5	-	7	1028	c.1029C>T	c.(1027-1029)ctC>ctT	p.L343L	CACNA1A_ENST00000573710.2_Silent_p.L343L	NM_000068.3|NM_001127222.1|NM_001174080.1|NM_023035.2	NP_000059.3|NP_001120694.1|NP_001167551.1|NP_075461.2	O00555	CAC1A_HUMAN	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	343					cell death|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|membrane depolarization|regulation of insulin secretion	cytoplasm|nucleus	syntaxin binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(25)|prostate(2)|urinary_tract(1)	42			OV - Ovarian serous cystadenocarcinoma(19;5.07e-21)		Bepridil(DB01244)|Cinnarizine(DB00568)|Loperamide(DB00836)|Nisoldipine(DB00401)|Pregabalin(DB00230)	CGATGATGATGAGGGGGATGA	0.522000													4	6					0	0	0.001168	0	0
CNTN3	5067	broad.mit.edu	37	3	74313648	74313648	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:74313648C>T	ENST00000263665.6	-	22	3018	c.2991G>A	c.(2989-2991)atG>atA	p.M997I	CNTN3_ENST00000477856.1_5'UTR	NM_020872.1	NP_065923.1	Q9P232	CNTN3_HUMAN	contactin 3 (plasmacytoma associated)	997					cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(39)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	83		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CTCTTGCATCCATACCTGTCA	0.398000													14	37					0	0	0.002450	0	0
CCT5	22948	broad.mit.edu	37	5	10263337	10263337	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:10263337C>T	ENST00000280326.4	+	10	1829	c.1409C>T	c.(1408-1410)cCc>cTc	p.P470L	CCT5_ENST00000515390.1_Missense_Mutation_p.P415L|CCT5_ENST00000506600.1_Missense_Mutation_p.P377L|CCT5_ENST00000503026.1_Missense_Mutation_p.P449L|CCT5_ENST00000515676.1_Missense_Mutation_p.P432L	NM_012073.3	NP_036205.1	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	470					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(13)|ovary(2)|pancreas(1)|prostate(2)	26						GGCATGAATCCCATCCAGACT	0.547000													25	69					0	0	0.003330	0	0
CLEC11A	6320	broad.mit.edu	37	19	51226853	51226853	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:51226853G>A	ENST00000250340.4	+	1	268	c.71G>A	c.(70-72)gGa>gAa	p.G24E	CLEC11A_ENST00000599973.1_Missense_Mutation_p.G24E	NM_002975.2	NP_002966.1	Q9Y240	CLC11_HUMAN	C-type lectin domain family 11, member A	24					positive regulation of cell proliferation	cytoplasm|extracellular region	growth factor activity|sugar binding			kidney(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	7		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GGGGCTCggggagcagagagg	0.642000													25	23					0	0	0.002780	0	0
DNAH10	196385	broad.mit.edu	37	12	124284801	124284801	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:124284801G>A	ENST00000409039.3	+	14	1999	c.1974G>A	c.(1972-1974)agG>agA	p.R658R		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	658	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CTTTAGAAAGGGGAGCTGTTT	0.478000													10	39					0	0	0.001855	0	0
ANKMY1	51281	broad.mit.edu	37	2	241494370	241494370	+	Translation_Start_Site	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:241494370C>A	ENST00000391987.1	-	0	348				ANKMY1_ENST00000405002.1_De_novo_Start_OutOfFrame|ANKMY1_ENST00000536462.1_Missense_Mutation_p.Q36H|ANKMY1_ENST00000406958.1_Missense_Mutation_p.Q83H|ANKMY1_ENST00000405523.3_Missense_Mutation_p.Q83H|ANKMY1_ENST00000462004.1_5'UTR|ANKMY1_ENST00000373318.2_Missense_Mutation_p.Q83H|ANKMY1_ENST00000361678.4_Missense_Mutation_p.Q83H|ANKMY1_ENST00000401804.1_Missense_Mutation_p.Q83H|ANKMY1_ENST00000373320.4_De_novo_Start_OutOfFrame|ANKMY1_ENST00000403283.1_Missense_Mutation_p.Q162H|ANKMY1_ENST00000272972.3_De_novo_Start_OutOfFrame			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1								zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		CCTGCCACTCCTGCACACCCT	0.572000													47	57					2.01872e-29	3.46128e-29	0.003610	1	0
SPEN	23013	broad.mit.edu	37	1	16262683	16262683	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:16262683C>T	ENST00000375759.3	+	11	10152	c.9948C>T	c.(9946-9948)ccC>ccT	p.P3316P		NM_015001.2	NP_055816.2	Q96T58	MINT_HUMAN	spen family transcriptional repressor	3316	Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			NS(1)|breast(13)|central_nervous_system(3)|cervix(5)|endometrium(16)|kidney(18)|large_intestine(27)|liver(2)|lung(37)|ovary(7)|prostate(7)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(1)	149		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CCTACCACCCCCCGGCCCAGC	0.632000													13	42					0	0	0.003163	0	0
DSC3	1825	broad.mit.edu	37	18	28609528	28609528	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:28609528G>T	ENST00000434452.1	-	4	575	c.421C>A	c.(421-423)Cct>Act	p.P141T	DSC3_ENST00000360428.4_Missense_Mutation_p.P141T	NM_024423.2	NP_077741.2	Q14574	DSC3_HUMAN	desmocollin 3	141	Cadherin 1.				homophilic cell adhesion|protein stabilization	desmosome|integral to membrane|membrane fraction	calcium ion binding|gamma-catenin binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(6)|lung(29)|ovary(2)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56			OV - Ovarian serous cystadenocarcinoma(10;0.125)			ATAGAGCAAGGAATAGGTGCC	0.413000													31	47					2.49991e-28	4.28448e-28	0.003271	1	0
YTHDC2	64848	broad.mit.edu	37	5	112915296	112915296	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:112915296C>T	ENST00000161863.4	+	24	3471	c.3258C>T	c.(3256-3258)ccC>ccT	p.P1086P		NM_022828.3	NP_073739.3	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1086							ATP binding|ATP-dependent helicase activity|nucleic acid binding			NS(2)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(6)|large_intestine(13)|lung(10)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	43		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		ATGGCATTCCCAATGACAGTA	0.378000													45	222					0	0	0.003610	0	0
ODF3L2	284451	broad.mit.edu	37	19	463914	463914	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:463914C>T	ENST00000315489.4	-	4	1035	c.800G>A	c.(799-801)cGg>cAg	p.R267Q	ODF3L2_ENST00000382696.3_Missense_Mutation_p.R231Q	NM_182577.2	NP_872383.1	Q3SX64	OD3L2_HUMAN	outer dense fiber of sperm tails 3-like 2	267										large_intestine(1)|lung(2)	3						GGTGCTGGCCCGTTTCGAGTG	0.701000													6	10					0	0	0.000673	0	0
PEX6	5190	broad.mit.edu	37	6	42934388	42934388	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:42934388C>T	ENST00000304611.8	-	10	2038	c.1969G>A	c.(1969-1971)Ggt>Agt	p.G657S	PEX6_ENST00000244546.4_Missense_Mutation_p.G657S	NM_000287.3	NP_000278.3	Q13608	PEX6_HUMAN	peroxisomal biogenesis factor 6	657					protein import into peroxisome matrix, translocation|protein stabilization	cytosol|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(3)	15			all cancers(41;0.00235)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.0562)			GTCAAGCCACCTGCCAAACTG	0.577000													31	170					0	0	0.001786	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121651385	121651385	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:121651385C>T	ENST00000393386.2	+	12	2696	c.2285C>T	c.(2284-2286)tCc>tTc	p.S762F	PTPRZ1_ENST00000483028.1_Intron|PTPRZ1_ENST00000449182.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	762					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						CTTCAACCTTCCTACAGTAGT	0.493000													55	57					0	0	0.003610	0	0
ACOT4	122970	broad.mit.edu	37	14	74062021	74062021	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:74062021C>T	ENST00000326303.4	+	3	1183	c.929C>T	c.(928-930)cCa>cTa	p.P310L		NM_152331.3	NP_689544.3	Q8N9L9	ACOT4_HUMAN	acyl-CoA thioesterase 4	310					acyl-CoA metabolic process|dicarboxylic acid metabolic process|long-chain fatty acid metabolic process|saturated monocarboxylic acid metabolic process|short-chain fatty acid metabolic process|succinyl-CoA metabolic process|unsaturated monocarboxylic acid metabolic process|very long-chain fatty acid metabolic process	peroxisome	carboxylesterase activity|palmitoyl-CoA hydrolase activity			endometrium(1)|large_intestine(3)|lung(4)	8				BRCA - Breast invasive adenocarcinoma(234;0.00331)		AGCATGATTCCAATAGAGAAG	0.493000													17	29					0	0	0.004007	0	0
KCNMB1	3779	broad.mit.edu	37	5	169810805	169810805	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:169810805C>T	ENST00000274629.4	-	3	626	c.184G>A	c.(184-186)Gac>Aac	p.D62N	KCNIP1_ENST00000377360.4_Intron|KCNMB1_ENST00000521859.1_Missense_Mutation_p.D62N|KCNIP1_ENST00000518527.1_Intron	NM_004137.3	NP_004128.1	Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, beta member 1	62					platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			endometrium(1)|large_intestine(1)|lung(7)|ovary(2)	11	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)		TCCTCCTGGTCCCTGATGTTG	0.582000													20	28					0	0	0.001216	0	0
LRRIQ1	84125	broad.mit.edu	37	12	85450849	85450849	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:85450849C>T	ENST00000393217.2	+	8	2339	c.2278C>T	c.(2278-2280)Caa>Taa	p.Q760*		NM_001079910.1	NP_001073379.1	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	760										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|liver(1)|lung(28)|ovary(5)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	83				GBM - Glioblastoma multiforme(134;0.212)		CAAGCAAAATCAACAAAAGAA	0.393000													78	200					0	0	0.003610	0	0
CXorf67	340602	broad.mit.edu	37	X	51149989	51149989	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:51149989C>T	ENST00000342995.2	+	1	223	c.121C>T	c.(121-123)Cct>Tct	p.P41S						chromosome X open reading frame 67											breast(1)|endometrium(4)|large_intestine(1)|lung(11)|ovary(3)|prostate(1)	21						GAATCAAGATCCTGCTGCTTC	0.662000													11	0					0	0	0.001368	0	0
NEGR1	257194	broad.mit.edu	37	1	72241872	72241872	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:72241872C>T	ENST00000357731.4	-	3	757	c.518G>A	c.(517-519)cGa>cAa	p.R173Q	NEGR1_ENST00000467479.1_5'UTR|NEGR1_ENST00000434200.1_Missense_Mutation_p.R171Q|NEGR1_ENST00000306821.3_Missense_Mutation_p.R45Q	NM_173808.2	NP_776169.2	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1	173	Ig-like C2-type 2.				cell adhesion	anchored to membrane|plasma membrane				endometrium(1)|kidney(4)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		GGAGATGTGTCGCCAAGAAAT	0.418000													16	11					0	0	0.004990	0	0
CCDC19	25790	broad.mit.edu	37	1	159860371	159860371	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:159860371G>A	ENST00000368099.4	-	3	235	c.171C>T	c.(169-171)ctC>ctT	p.L57L	CCDC19_ENST00000476696.1_5'UTR|CCDC19_ENST00000426543.2_5'UTR	NM_012337.2	NP_036469.2	Q9UL16	CCD19_HUMAN	coiled-coil domain containing 19	57						mitochondrion|soluble fraction				endometrium(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	26	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			GCTTATCTCGGAGCAGCACAA	0.542000													39	122					0	0	0.002522	0	0
EI24	9538	broad.mit.edu	37	11	125448110	125448110	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:125448110C>T	ENST00000278903.6	+	6	640	c.398C>T	c.(397-399)cCc>cTc	p.P133L	STT3A-AS1_ENST00000532714.1_RNA|STT3A-AS1_ENST00000530526.1_RNA|EI24_ENST00000343678.4_Missense_Mutation_p.P133L|EI24_ENST00000530985.1_3'UTR	NM_004879.3	NP_004870.3	O14681	EI24_HUMAN	etoposide induced 2.4	133					apoptosis|autophagy|induction of apoptosis|negative regulation of cell growth	endoplasmic reticulum membrane|integral to membrane|nuclear membrane				large_intestine(1)|lung(9)|ovary(1)	11	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.64e-07)|OV - Ovarian serous cystadenocarcinoma(99;0.0975)		TGGGTGCTCCCCTTGTTTGTG	0.502000													46	59					0	0	0.003610	0	0
IL17RD	54756	broad.mit.edu	37	3	57139951	57139951	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:57139951G>A	ENST00000296318.7	-	7	769	c.681C>T	c.(679-681)ttC>ttT	p.F227F	IL17RD_ENST00000463523.1_Silent_p.F83F|IL17RD_ENST00000320057.5_Silent_p.F83F|IL17RD_ENST00000427856.2_Silent_p.F203F	NM_017563.3	NP_060033.3	Q8NFM7	I17RD_HUMAN	interleukin 17 receptor D	227						Golgi membrane|integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(1)|ovary(1)|pancreas(1)	16				KIRC - Kidney renal clear cell carcinoma(284;0.0173)|Kidney(284;0.0204)		AGAAGAAACGGAAGCCGAAGT	0.522000													12	30					0	0	0.002450	0	0
SPESP1	246777	broad.mit.edu	37	15	69223036	69223036	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:69223036C>T	ENST00000310673.3	+	1	198	c.44C>T	c.(43-45)tCg>tTg	p.S15L	SPESP1_ENST00000560188.1_Intron|NOX5_ENST00000260364.5_5'UTR|NOX5_ENST00000448182.3_5'UTR|RP11-809H16.2_ENST00000557966.1_RNA|NOX5_ENST00000455873.3_Silent_p.F3F	NM_145658.3	NP_663633.1	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1	15					multicellular organismal development	acrosomal vesicle				breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(11)|prostate(1)|skin(1)|urinary_tract(1)	19						CTATGGCCTTCGTCTGTGCCG	0.642000													32	43					0	0	0.006230	0	0
AMER1	139285	broad.mit.edu	37	X	63410326	63410326	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:63410326G>A	ENST00000330258.3	-	2	3113	c.2841C>T	c.(2839-2841)tcC>tcT	p.S947S	AMER1_ENST00000403336.1_Intron|AMER1_ENST00000374869.3_Intron	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									CAGTATAGAGGGAAAGGGGAC	0.587000													6	1					0	0	0.001984	0	0
CUBNP3	100421634	broad.mit.edu	37	10	45642855	45642855	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:45642855C>T	ENST00000427229.2	+	0	14																											AATATCACCTCCTAGGAAATA	0.438000													4	6					0	0	0.000248	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86522401	86522401	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:86522401A>C	ENST00000450689.2	-	20	2886	c.2701T>G	c.(2701-2703)Tgg>Ggg	p.W901G	KIAA1324L_ENST00000297222.6_Missense_Mutation_p.W661G|KIAA1324L_ENST00000416314.1_Missense_Mutation_p.W734G|KIAA1324L_ENST00000444627.1_Missense_Mutation_p.W830G	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	901						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					GGTTCATTCCACACATACAAG	0.383000													28	57					0	0	0.007291	0	0
TNXB	7148	broad.mit.edu	37	6	32026088	32026088	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32026088G>A	ENST00000375244.3	-	22	7773	c.7572C>T	c.(7570-7572)ctC>ctT	p.L2524L	TNXB_ENST00000375247.2_Silent_p.L2524L			P22105	TENX_HUMAN	tenascin XB	2584	Fibronectin type-III 17.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GCTCCCCCAGGAGAGGCTCCT	0.632000													93	968					0	0	0.003610	0	0
BPI	671	broad.mit.edu	37	20	36932652	36932652	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:36932652G>A	ENST00000262865.4	+	1	128	c.39G>A	c.(37-39)ccG>ccA	p.P13P	CTD-2308N23.2_ENST00000437016.1_RNA	NM_001725.2	NP_001716.2	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	13					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding	p.P13P(1)		kidney(1)|large_intestine(6)|lung(15)|ovary(4)|prostate(2)|stomach(1)|urinary_tract(1)	30		Myeloproliferative disorder(115;0.00878)				GCAACGCGCCGAGATGGGCGT	0.617000													22	116					0	0	0.003954	0	0
ATAD2B	54454	broad.mit.edu	37	2	23985211	23985211	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:23985211A>T	ENST00000238789.5	-	24	3605	c.3262T>A	c.(3262-3264)Tca>Aca	p.S1088T	ATAD2B_ENST00000474583.1_5'UTR	NM_001242338.1|NM_017552.2	NP_001229267.1|NP_060022.1	Q9ULI0	ATD2B_HUMAN	ATPase family, AAA domain containing 2B	1088							ATP binding|nucleoside-triphosphatase activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GATGTTACTGATAAGCCTGCA	0.353000													12	35					0	0	0.000978	0	0
COL28A1	340267	broad.mit.edu	37	7	7480434	7480434	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:7480434G>A	ENST00000399429.3	-	21	1849	c.1709C>T	c.(1708-1710)cCc>cTc	p.P570L		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	570	Collagen-like 5.				cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		TGGTCCTTCGGGCCCTGGAAG	0.373000													27	136					0	0	0.001786	0	0
SLC6A15	55117	broad.mit.edu	37	12	85255683	85255683	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:85255683G>A	ENST00000266682.5	-	12	2462	c.1921C>T	c.(1921-1923)Cgc>Tgc	p.R641C	SLC6A15_ENST00000309283.7_Intron|SLC6A15_ENST00000552192.1_Missense_Mutation_p.R534C	NM_182767.5	NP_877499.1	Q9H2J7	S6A15_HUMAN	solute carrier family 6 (neutral amino acid transporter), member 15	641					cellular nitrogen compound metabolic process|leucine transport|proline transport	integral to plasma membrane	amino acid transmembrane transporter activity|neurotransmitter:sodium symporter activity			kidney(1)|large_intestine(18)|lung(15)|ovary(1)|pancreas(2)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	44						AGGTTGAAGCGACGAACAATG	0.433000													32	107					0	0	0.001786	0	0
PRDX1	5052	broad.mit.edu	37	1	45980275	45980275	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:45980275G>A	ENST00000262746.1	-	5	757	c.418C>T	c.(418-420)Cgg>Tgg	p.R140W	PRDX1_ENST00000319248.8_Missense_Mutation_p.R140W|PRDX1_ENST00000372079.1_Missense_Mutation_p.R38W	NM_002574.3|NM_181696.2	NP_002565.1|NP_859047.1	Q06830	PRDX1_HUMAN	peroxiredoxin 1	140	Thioredoxin.				cell proliferation|cell redox homeostasis|hydrogen peroxide catabolic process|skeletal system development	melanosome|mitochondrion|nucleus	protein binding|thioredoxin peroxidase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(5)|skin(1)	12	Acute lymphoblastic leukemia(166;0.155)					GTGATCTGCCGAAGAATACCC	0.443000													43	102					0	0	0.003610	0	0
AOC1	26	broad.mit.edu	37	7	150554425	150554425	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:150554425G>A	ENST00000493429.1	+	4	1451	c.867G>A	c.(865-867)ggG>ggA	p.G289G	AOC1_ENST00000360937.4_Silent_p.G289G|AOC1_ENST00000467291.1_Silent_p.G289G|AOC1_ENST00000416793.2_Silent_p.G289G					amine oxidase, copper containing 1																		AGCCCCGCGGGGACTTCCCCA	0.701000													4	4					0	0	0.000248	0	0
MYH10	4628	broad.mit.edu	37	17	8451692	8451692	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:8451692A>C	ENST00000360416.3	-	11	1236	c.1098T>G	c.(1096-1098)ttT>ttG	p.F366L	MYH10_ENST00000396239.1_Missense_Mutation_p.F356L|MYH10_ENST00000379980.4_Missense_Mutation_p.F372L|MYH10_ENST00000269243.4_Missense_Mutation_p.F356L	NM_001256012.1	NP_001242941.1	P35580	MYH10_HUMAN	myosin, heavy chain 10, non-muscle	356	Myosin head-like.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			breast(5)|endometrium(9)|kidney(2)|large_intestine(16)|lung(9)|ovary(3)|prostate(3)|skin(4)|stomach(1)	52						AAATATTTCCAAACTGTAGCA	0.313000													16	52					0	0	0.007413	0	0
KDR	3791	broad.mit.edu	37	4	55976879	55976879	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:55976879C>T	ENST00000263923.4	-	8	1328	c.1033G>A	c.(1033-1035)Ggg>Agg	p.G345R		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	345	Ig-like C2-type 4.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	ACACGCTCCCCCACCGTGGCT	0.413000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			41	183					0	0	0.003610	0	0
ZNF793	390927	broad.mit.edu	37	19	38024235	38024235	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:38024235G>A	ENST00000445217.1	+	3	203	c.168G>A	c.(166-168)gtG>gtA	p.V56V	ZNF793_ENST00000587143.1_Silent_p.V56V|ZNF793_ENST00000542455.1_Silent_p.V56V|ZNF793_ENST00000589319.1_Silent_p.V56V|ZNF793_ENST00000588578.1_Silent_p.V56V|ZNF793_ENST00000587986.1_Silent_p.V56V			Q6ZN11	ZN793_HUMAN	zinc finger protein 793	56	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|lung(1)	3			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AACCAGATGTGATCCTCAGAC	0.532000													37	81					0	0	0.004878	0	0
SLC34A1	6569	broad.mit.edu	37	5	176812796	176812796	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:176812796C>T	ENST00000324417.5	+	2	145	c.54C>T	c.(52-54)gtC>gtT	p.V18V	SLC34A1_ENST00000512593.1_Silent_p.V18V	NM_003052.4	NP_003043.3	Q06495	NPT2A_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 1	18					phosphate ion homeostasis|response to cadmium ion|response to lead ion|response to mercury ion|sodium ion transport	brush border membrane|integral to plasma membrane	protein binding|sodium-dependent phosphate transmembrane transporter activity|symporter activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	24	all_cancers(89;2.04e-05)|Renal(175;0.000269)|Lung NSC(126;0.000832)|all_lung(126;0.00152)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CACTCCCAGTCCGTGGGGGGC	0.647000													29	26					0	0	0.002096	0	0
NAV3	89795	broad.mit.edu	37	12	78604241	78604241	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:78604241G>A	ENST00000397909.2	+	40	7275	c.7102G>A	c.(7102-7104)Gaa>Aaa	p.E2368K	NAV3_ENST00000228327.6_Missense_Mutation_p.E2346K|NAV3_ENST00000536525.2_Missense_Mutation_p.E2346K|NAV3_ENST00000266692.7_Missense_Mutation_p.E2169K|NAV3_ENST00000541270.1_Missense_Mutation_p.E198K			Q8IVL0	NAV3_HUMAN	neuron navigator 3	2368						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			NS(2)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(13)|kidney(16)|large_intestine(39)|liver(2)|lung(126)|ovary(5)|pancreas(3)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(1)	236						CTGCGACAGCGAAAGCACCAG	0.388000										HNSCC(70;0.22)			8	36					0	0	0.004482	0	0
DSG3	1830	broad.mit.edu	37	18	29055678	29055678	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:29055678G>A	ENST00000257189.4	+	16	2538	c.2455G>A	c.(2455-2457)Gaa>Aaa	p.E819K		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	819					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CTATGATAATGAAGGCGCAGA	0.473000													23	37					0	0	0.003330	0	0
C1orf158	93190	broad.mit.edu	37	1	12819250	12819250	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:12819250C>T	ENST00000288048.5	+	3	449	c.233C>T	c.(232-234)cCt>cTt	p.P78L	C1orf158_ENST00000376210.3_Missense_Mutation_p.P40L	NM_152290.2	NP_689503.2	Q8N1D5	CA158_HUMAN	chromosome 1 open reading frame 158	78										central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(1)|ovary(1)|skin(2)|urinary_tract(3)	10	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00575)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		CAGGGGCTACCTTACAAACAC	0.577000													47	132					0	0	0.003610	0	0
NEUROD6	63974	broad.mit.edu	37	7	31378726	31378726	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:31378726C>T	ENST00000297142.3	-	2	479	c.157G>A	c.(157-159)Gga>Aga	p.G53R		NM_022728.2	NP_073565.2	Q96NK8	NDF6_HUMAN	neuronal differentiation 6	53					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(18)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	32						gtttcttctccAGGGGCCCTT	0.433000													26	55					0	0	0.003954	0	0
UBR4	23352	broad.mit.edu	37	1	19454738	19454738	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:19454738G>A	ENST00000375267.2	-	62	9081	c.9078C>T	c.(9076-9078)tcC>tcT	p.S3026S	UBR4_ENST00000375217.2_Silent_p.S3019S|UBR4_ENST00000375254.3_Silent_p.S3026S|UBR4_ENST00000375226.2_Silent_p.S3002S			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	3026					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CAATAAGCTGGGAGAGCAGGT	0.448000													43	103					0	0	0.003214	0	0
C7	730	broad.mit.edu	37	5	40945459	40945459	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:40945459C>T	ENST00000313164.9	+	7	1086	c.727C>T	c.(727-729)Cat>Tat	p.H243Y		NM_000587.2	NP_000578.2	P10643	CO7_HUMAN	complement component 7	243	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex							Ovarian(839;0.0112)				CAATGAAATCCATAAAGGAAA	0.323000													20	47					0	0	0.002299	0	0
SCN9A	6335	broad.mit.edu	37	2	167142945	167142945	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:167142945C>T	ENST00000375387.4	-	11	1846	c.1506G>A	c.(1504-1506)tcG>tcA	p.S502S	SCN9A_ENST00000409435.1_Silent_p.S501S|SCN9A_ENST00000409672.1_Silent_p.S501S|AC010127.3_ENST00000447809.2_RNA|SCN9A_ENST00000303354.6_Silent_p.S502S			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	501						voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.S501S(1)		NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	ATTCTGATTTCGACAATTTCT	0.428000													47	46					0	0	0.003610	0	0
PCLO	27445	broad.mit.edu	37	7	82453677	82453677	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:82453677G>A	ENST00000423517.2	-	19	14808	c.14471C>T	c.(14470-14472)cCt>cTt	p.P4824L	PCLO_ENST00000333891.8_Missense_Mutation_p.P4824L|PCLO_ENST00000426442.2_5'UTR	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4686					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TTCTTTGAGAGGATACCACCT	0.398000													20	34					0	0	0.001882	0	0
EPHA3	2042	broad.mit.edu	37	3	89468381	89468381	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:89468381C>T	ENST00000336596.2	+	11	2140	c.1915C>T	c.(1915-1917)Cgc>Tgc	p.R639C	EPHA3_ENST00000494014.1_Missense_Mutation_p.R639C	NM_005233.5	NP_005224.2	P29320	EPHA3_HUMAN	EPH receptor A3	639	Protein kinase.					extracellular region|integral to plasma membrane	ATP binding			NS(1)|breast(4)|central_nervous_system(4)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(26)|liver(3)|lung(67)|ovary(7)|pancreas(1)|prostate(4)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)	139	all_cancers(8;0.0406)|Melanoma(1;0.00142)|all_epithelial(1;0.0612)	Lung NSC(201;0.0782)		LUSC - Lung squamous cell carcinoma(29;0.00344)|Lung(72;0.00942)		GTGCAGTGGTCGCTTAAAACT	0.393000										TSP Lung(6;0.00050)			24	76					0	0	0.006320	0	0
DDHD1	80821	broad.mit.edu	37	14	53539314	53539314	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:53539314C>T	ENST00000357758.3	-	6	1687		c.e6+1		DDHD1_ENST00000395606.1_Splice_Site|DDHD1_ENST00000323669.5_Splice_Site	NM_030637.2	NP_085140.2	Q8NEL9	DDHD1_HUMAN	DDHD domain containing 1						lipid catabolic process	cytoplasm	hydrolase activity|metal ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(4)|lung(11)|ovary(3)|prostate(1)	25	Breast(41;0.037)					ATGACACTTACTTCATCTCTA	0.318000													13	21					0	0	0.001368	0	0
CASK	8573	broad.mit.edu	37	X	41416311	41416311	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:41416311G>A	ENST00000318588.9	-	19	1825	c.1780C>T	c.(1780-1782)Cat>Tat	p.H594Y	CASK_ENST00000378163.1_Missense_Mutation_p.H594Y|CASK_ENST00000378166.4_Missense_Mutation_p.H594Y|CASK_ENST00000378158.1_Missense_Mutation_p.H594Y|CASK_ENST00000361962.4_Missense_Mutation_p.H594Y|CASK_ENST00000442742.2_Intron|CASK_ENST00000472704.1_Intron|CASK_ENST00000421587.2_Intron			O14936	CSKP_HUMAN	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	594					cell adhesion	actin cytoskeleton|cytoplasm|nucleus|plasma membrane	ATP binding|calmodulin binding|guanylate kinase activity|protein serine/threonine kinase activity			breast(3)|endometrium(5)|kidney(1)|large_intestine(6)|liver(1)|lung(11)|ovary(3)|prostate(1)|stomach(1)	32						GTGCTGCTATGACCATTAGCT	0.433000													21	2					0	0	0.006320	0	0
IL10RA	3587	broad.mit.edu	37	11	117864127	117864127	+	Splice_Site	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:117864127T>A	ENST00000227752.3	+	4	657		c.e4+2		IL10RA_ENST00000533700.1_Splice_Site|IL10RA_ENST00000541785.1_Splice_Site|IL10RA_ENST00000545409.1_Splice_Site	NM_001558.3	NP_001549.2	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha							integral to membrane|plasma membrane	interleukin-10 receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(10)|ovary(2)|prostate(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		AACTTCACGGTATGGGGTTCC	0.557000													25	7					0	0	0.004656	0	0
DBX2	440097	broad.mit.edu	37	12	45410236	45410236	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:45410236G>T	ENST00000332700.6	-	4	1024	c.853C>A	c.(853-855)Cag>Aag	p.Q285K		NM_001004329.2	NP_001004329.2	Q6ZNG2	DBX2_HUMAN	developing brain homeobox 2	285						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(3)|kidney(1)|large_intestine(3)|lung(9)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	22	Lung SC(27;0.192)	Lung NSC(34;0.142)		GBM - Glioblastoma multiforme(48;0.0515)		CTTGAGTGCTGTTGGGGGACG	0.512000													24	74					2.49675e-24	4.27347e-24	0.007291	1	0
ALK	238	broad.mit.edu	37	2	29917849	29917849	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:29917849C>T	ENST00000389048.3	-	3	1725	c.819G>A	c.(817-819)gaG>gaA	p.E273E	ALK_ENST00000431873.1_Intron	NM_004304.4	NP_004295.2	Q9UM73	ALK_HUMAN	anaplastic lymphoma receptor tyrosine kinase	273	MAM 1.				protein autophosphorylation|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity		ATIC/ALK(24)|FN1/ALK(2)|C2orf44/ALK(2)|TPM3/ALK(33)|KLC1/ALK(2)|VCL/ALK(4)|TPM4/ALK(12)|KIF5B/ALK(8)|RANBP2/ALK(34)|SQSTM1/ALK(2)|EML4/ALK(543)|PPFIBP1/ALK(3)|SEC31A/ALK(3)|NPM1/ALK(632)|CLTC/ALK(44)|CARS/ALK(5)|MSN/ALK(6)|TFG/ALK(9)	NS(2)|autonomic_ganglia(198)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(4)|large_intestine(25)|lung(61)|ovary(6)|pancreas(1)|prostate(2)|skin(5)|soft_tissue(3)|stomach(2)|thyroid(2)	340	Acute lymphoblastic leukemia(172;0.155)				Adenosine triphosphate(DB00171)	AATACTCCAGCTCACAGGGGA	0.567000			"""T, Mis, A"""	"""NPM1, TPM3, TFG, TPM4, ATIC, CLTC, MSN, ALO17, CARS, EML4, KIF5B, C2orf22"""	"""ALCL, NSCLC, Neuroblastoma"""	neuroblastoma			Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				24	75					0	0	0.003954	0	0
FGD5	152273	broad.mit.edu	37	3	14949198	14949198	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:14949198G>A	ENST00000285046.5	+	10	3426	c.3316G>A	c.(3316-3318)Gat>Aat	p.D1106N	FGD5_ENST00000476851.1_3'UTR|FGD5_ENST00000543601.1_Missense_Mutation_p.D865N	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1106					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						GGGCCAAGGGGATCTCCTCCA	0.647000													14	33					0	0	0.004007	0	0
OR7G2	390882	broad.mit.edu	37	19	9213450	9213450	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9213450A>T	ENST00000305456.2	-	1	532	c.533T>A	c.(532-534)cTt>cAt	p.L178H		NM_001005193.1	NP_001005193.1	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G, member 2	157					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|skin(3)	16						GCTGAGAAGAAGGGCATTCAC	0.517000													11	15					0	0	0.000978	0	0
PKLR	5313	broad.mit.edu	37	1	155264450	155264450	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:155264450C>T	ENST00000392414.3	-	6	808	c.695G>A	c.(694-696)gGg>gAg	p.G232E	PKLR_ENST00000342741.4_Missense_Mutation_p.G263E	NM_181871.3	NP_870986.1	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC	263					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(16)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	35	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	CTCGGACAGCCCGGGCAAGTC	0.677000													22	9					0	0	0.002299	0	0
MBD5	55777	broad.mit.edu	37	2	149226560	149226560	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:149226560C>T	ENST00000407073.1	+	9	2045	c.1048C>T	c.(1048-1050)Cca>Tca	p.P350S	MBD5_ENST00000404807.1_Missense_Mutation_p.P350S	NM_018328.4	NP_060798.2	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	350	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(1)|large_intestine(16)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)	62				BRCA - Breast invasive adenocarcinoma(221;0.0569)		TCAGAAAAAGCCATTAACATC	0.438000													12	22					0	0	0.000978	0	0
PROL1	58503	broad.mit.edu	37	4	71275427	71275427	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:71275427C>T	ENST00000399575.2	+	3	556	c.382C>T	c.(382-384)Cct>Tct	p.P128S	PROL1_ENST00000514338.1_3'UTR	NM_021225.4	NP_067048.4	Q99935	PROL1_HUMAN	proline rich, lacrimal 1	128	Pro-rich.				regulation of sensory perception of pain	extracellular region	endopeptidase inhibitor activity	p.P128S(1)		endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|prostate(1)|skin(3)	15		all_hematologic(202;0.196)				TCCTCCTATTCCTTTTTTTCT	0.433000													38	54					0	0	0.006999	0	0
PHLPP2	23035	broad.mit.edu	37	16	71701153	71701153	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:71701153G>A	ENST00000393524.2	-	11	2445	c.1712C>T	c.(1711-1713)cCc>cTc	p.P571L	PHLPP2_ENST00000568954.1_Missense_Mutation_p.P571L|PHLPP2_ENST00000356272.3_Missense_Mutation_p.P571L|PHLPP2_ENST00000567016.1_Missense_Mutation_p.P606L|PHLPP2_ENST00000360429.3_Missense_Mutation_p.P571L			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	645						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						CACCTCGAGGGGGATGTGCTC	0.473000													27	52					0	0	0.004656	0	0
SKIV2L	6499	broad.mit.edu	37	6	31928457	31928457	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31928457C>T	ENST00000375394.2	+	6	597	c.484C>T	c.(484-486)Ccc>Tcc	p.P162S	SKIV2L_ENST00000544581.1_Intron|SKIV2L_ENST00000488648.1_3'UTR	NM_006929.4	NP_008860.4	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like (S. cerevisiae)	162						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			breast(1)|central_nervous_system(1)|large_intestine(1)|ovary(1)	4						GATGGATGAACCCACCATAAC	0.527000													103	1088					0	0	0.003610	0	0
RYR1	6261	broad.mit.edu	37	19	38996449	38996449	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:38996449A>T	ENST00000355481.4	+	54	8535	c.8404A>T	c.(8404-8406)Aaa>Taa	p.K2802*	RYR1_ENST00000359596.3_Nonsense_Mutation_p.K2802*|RYR1_ENST00000360985.3_Nonsense_Mutation_p.K2802*	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	2802	6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	ACCCCAGGACAAAGAGATTTA	0.577000													8	18					0	0	0.004482	0	0
NPAS4	266743	broad.mit.edu	37	11	66191616	66191616	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:66191616G>A	ENST00000311034.2	+	7	1431	c.1255G>A	c.(1255-1257)Gat>Aat	p.D419N		NM_178864.3	NP_849195.2	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	419					transcription, DNA-dependent		DNA binding|signal transducer activity			breast(4)|endometrium(2)|kidney(3)|large_intestine(11)|liver(2)|lung(20)|ovary(1)|prostate(3)|skin(3)	49						ACTAAGCAAGGATCTTGTGTG	0.557000													47	55					0	0	0.003610	0	0
NBPF1	55672	broad.mit.edu	37	1	16902764	16902764	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:16902764G>A	ENST00000430580.2	-	19	3004	c.2117C>T	c.(2116-2118)cCa>cTa	p.P706L	NBPF1_ENST00000432949.1_Missense_Mutation_p.P164L|NBPF1_ENST00000287968.8_Missense_Mutation_p.P71L	NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1	706						cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CACCTTACCTGGGCTGAGCTT	0.537000													14	355					0	0	0.001523	0	0
SYT16	83851	broad.mit.edu	37	14	62536400	62536400	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:62536400C>T	ENST00000430451.2	+	2	800	c.603C>T	c.(601-603)tcC>tcT	p.S201S	RP11-355I22.5_ENST00000553990.1_lincRNA|SYT16_ENST00000446982.2_Silent_p.S201S	NM_031914.2	NP_114120.2	Q17RD7	SYT16_HUMAN	synaptotagmin XVI	201										central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(12)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	35				OV - Ovarian serous cystadenocarcinoma(108;0.0438)|BRCA - Breast invasive adenocarcinoma(234;0.118)		TTGAGATTTCCGTGTCCCGGT	0.483000													40	47					0	0	0.002522	0	0
RBM24	221662	broad.mit.edu	37	6	17292259	17292259	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:17292259G>A	ENST00000379052.5	+	4	856	c.620G>A	c.(619-621)gGg>gAg	p.G207E	RBM24_ENST00000318204.5_Missense_Mutation_p.G162E|RBM24_ENST00000425446.2_Missense_Mutation_p.G149E|RBM24_ENST00000508508.1_3'UTR	NM_001143942.1	NP_001137414.1	Q9BX46	RBM24_HUMAN	RNA binding motif protein 24	207	Ala-rich.				cell differentiation|regulation of mRNA stability|regulation of myotube differentiation	cytoplasm|nucleus	mRNA 3'-UTR binding|nucleotide binding			endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|prostate(2)|skin(1)	13	Breast(50;0.0615)|Ovarian(93;0.0733)	all_hematologic(90;0.062)	all cancers(50;0.131)|Epithelial(50;0.15)			GCGGCACCTGGGACAgctgcc	0.622000													6	24					0	0	0.001168	0	0
FAM161A	84140	broad.mit.edu	37	2	62067438	62067438	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:62067438G>A	ENST00000404929.1	-	3	712	c.701C>T	c.(700-702)cCc>cTc	p.P234L	FAM161A_ENST00000405894.3_Missense_Mutation_p.P234L	NM_001201543.1	NP_001188472.1	Q3B820	F161A_HUMAN	family with sequence similarity 161, member A	234					response to stimulus|visual perception	centrosome				breast(1)|endometrium(5)|large_intestine(8)|lung(4)|ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	25						TGTAATTGTGGGCACCCATTC	0.363000													25	78					0	0	0.004656	0	0
POM121L9P	29774	broad.mit.edu	37	22	24658524	24658524	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:24658524C>T	ENST00000414583.2	+	0	2941					NR_003714.1																						CCGACATGTCCTTCTTATCTG	0.562000													12	28					0	0	0.003163	0	0
PRICKLE1	144165	broad.mit.edu	37	12	42853643	42853643	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:42853643C>T	ENST00000455697.1	-	8	2749	c.2464G>A	c.(2464-2466)Gga>Aga	p.G822R	PRICKLE1_ENST00000548696.1_Missense_Mutation_p.G822R|PRICKLE1_ENST00000445766.2_Missense_Mutation_p.G822R|PRICKLE1_ENST00000552240.1_Missense_Mutation_p.G822R|PRICKLE1_ENST00000345127.3_Missense_Mutation_p.G822R|RP11-328C8.4_ENST00000547824.1_RNA	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	822					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		CCCTTGTGTCCCTTTTTCTTC	0.398000													22	103					0	0	0.001882	0	0
DHX40	79665	broad.mit.edu	37	17	57650525	57650525	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:57650525C>T	ENST00000451169.2	+	4	537	c.178C>T	c.(178-180)Ctg>Ttg	p.L60L	DHX40_ENST00000251241.4_Silent_p.L159L|DHX40_ENST00000425628.3_Silent_p.L82L			Q8IX18	DHX40_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 40	159							ATP binding|ATP-dependent helicase activity|nucleic acid binding			endometrium(7)|large_intestine(6)|lung(6)|prostate(1)	20	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					GAAACATATTCTGGGAGACCC	0.328000													119	60					0	0	0.003610	0	0
TNS1	7145	broad.mit.edu	37	2	218712399	218712399	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:218712399G>A	ENST00000171887.4	-	17	2918	c.2466C>T	c.(2464-2466)ttC>ttT	p.F822F	TNS1_ENST00000419504.1_Silent_p.F822F|TNS1_ENST00000430930.1_Silent_p.F822F	NM_022648.4	NP_072174.3	Q9HBL0	TENS1_HUMAN	tensin 1	822						cytoplasm|cytoskeleton|focal adhesion	actin binding			breast(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(23)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	79		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TGGTCGGAAGGAAGGCAGGCA	0.582000													20	26					0	0	0.007413	0	0
ILDR2	387597	broad.mit.edu	37	1	166896407	166896407	+	Silent	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:166896407A>G	ENST00000271417.3	-	7	946	c.891T>C	c.(889-891)ggT>ggC	p.G297G	ILDR2_ENST00000529071.1_Silent_p.G278G|ILDR2_ENST00000528703.1_Silent_p.G238G|ILDR2_ENST00000526687.1_Silent_p.G189G|ILDR2_ENST00000525740.1_Silent_p.G170G|ILDR2_ENST00000469934.2_Silent_p.G297G|ILDR2_ENST00000529387.1_Intron	NM_199351.2	NP_955383.1	Q71H61	ILDR2_HUMAN	immunoglobulin-like domain containing receptor 2	297						integral to membrane				NS(3)|breast(1)|kidney(2)|large_intestine(2)|lung(9)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	22						GGATCCGGTAACCTTTGCGAA	0.453000													95	41					0	0	0.003610	0	0
HSF2	3298	broad.mit.edu	37	6	122743417	122743417	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:122743417T>G	ENST00000452194.1	+	8	991	c.804T>G	c.(802-804)aaT>aaG	p.N268K	HSF2_ENST00000465214.1_3'UTR|HSF2_ENST00000368455.4_Missense_Mutation_p.N268K	NM_001135564.1	NP_001129036.1	Q03933	HSF2_HUMAN	heat shock transcription factor 2	268					response to stress|transcription from RNA polymerase II promoter	cytoplasm|nucleus	sequence-specific DNA binding transcription factor activity|transcription coactivator activity			large_intestine(4)|lung(6)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16				OV - Ovarian serous cystadenocarcinoma(136;0.00371)|all cancers(137;0.0299)|GBM - Glioblastoma multiforme(226;0.0586)		CAGAAACTAATGAGGATGTTA	0.308000													60	96					0	0	0.003610	0	0
ASRGL1	80150	broad.mit.edu	37	11	62159581	62159581	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:62159581C>T	ENST00000415229.2	+	7	967	c.752C>T	c.(751-753)tCg>tTg	p.S251L	ASRGL1_ENST00000301776.5_Missense_Mutation_p.S251L|CTD-2531D15.5_ENST00000526045.1_RNA	NM_001083926.1	NP_001077395.1	Q7L266	ASGL1_HUMAN	asparaginase like 1	251					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity			endometrium(1)|kidney(1)|lung(1)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	7					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	GCGGACCTATCGTTGGGTTAT	0.478000											OREG0021023	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	24	43					0	0	0.005443	0	0
PAPSS1	9061	broad.mit.edu	37	4	108603283	108603283	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:108603283G>A	ENST00000265174.4	-	5	829	c.557C>T	c.(556-558)aCt>aTt	p.T186I	PAPSS1_ENST00000511304.1_5'UTR	NM_005443.4	NP_005434.4	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 1	186					3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			NS(1)|endometrium(2)|kidney(5)|large_intestine(2)|lung(5)|ovary(1)	16		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)		ATCGATCCCAGTGAAACCTGC	0.383000													35	57					0	0	0.005524	0	0
CRABP2	1382	broad.mit.edu	37	1	156670740	156670740	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:156670740C>G	ENST00000368222.3	-	2	329	c.175G>C	c.(175-177)Gtg>Ctg	p.V59L	CRABP2_ENST00000368221.1_Missense_Mutation_p.V59L	NM_001199723.1|NM_001878.3	NP_001186652.1|NP_001869.1	P29373	RABP2_HUMAN	cellular retinoic acid binding protein 2	59					epidermis development|regulation of transcription, DNA-dependent|signal transduction	cytoplasm|nucleus	retinal binding|retinol binding|transporter activity			endometrium(2)|lung(3)|upper_aerodigestive_tract(1)	6	all_hematologic(923;0.088)|Hepatocellular(266;0.158)				Alitretinoin(DB00523)	GTGGTGCGCACGGTGGTGGAG	0.547000													13	57					0	0	0.002450	0	0
DSP	1832	broad.mit.edu	37	6	7581101	7581101	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:7581101C>T	ENST00000379802.3	+	23	5019	c.4678C>T	c.(4678-4680)Cag>Tag	p.Q1560*	DSP_ENST00000418664.2_Intron	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1560	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CACGCGGTTCCAGAACTCTCT	0.527000													29	157					0	0	0.006320	0	0
FAM49A	81553	broad.mit.edu	37	2	16740731	16740731	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:16740731G>A	ENST00000381323.3	-	10	1054	c.834C>T	c.(832-834)atC>atT	p.I278I	FAM49A_ENST00000355549.2_Silent_p.I278I|FAM49A_ENST00000406434.1_Silent_p.I278I	NM_030797.3	NP_110424.1	Q9H0Q0	FA49A_HUMAN	family with sequence similarity 49, member A	278						intracellular				breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	23	Acute lymphoblastic leukemia(172;0.0734)|all_hematologic(175;0.088)		GBM - Glioblastoma multiforme(3;0.00969)			TTCTTACATCGATCTTGGATG	0.483000													37	81					0	0	0.005524	0	0
ATP1A2	477	broad.mit.edu	37	1	160105224	160105224	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:160105224G>A	ENST00000361216.3	+	16	2205	c.2115_splice	c.e16-1	p.G706_splice	ATP1A2_ENST00000392233.3_Splice_Site_p.G706_splice|ATP1A2_ENST00000472488.1_3'UTR	NM_000702.3	NP_000693.1	P50993	AT1A2_HUMAN	ATPase, Na+/K+ transporting, alpha 2 polypeptide	706					ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(30)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	69	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			TTCCCTCCAGGGAGCCATTGT	0.617000													9	58					0	0	0.000673	0	0
PRKACG	5568	broad.mit.edu	37	9	71628097	71628097	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:71628097G>A	ENST00000377276.2	-	1	942	c.912C>T	c.(910-912)atC>atT	p.I304I		NM_002732.3	NP_002723.2	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic, gamma	304	AGC-kinase C-terminal.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						CATAGATGGCGATCCAGCTGG	0.572000													24	93					0	0	0.004656	0	0
PRR19	284338	broad.mit.edu	37	19	42813859	42813859	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:42813859C>T	ENST00000499536.2	+	1	934	c.123C>T	c.(121-123)gcC>gcT	p.A41A	PRR19_ENST00000341747.3_Silent_p.A41A|PRR19_ENST00000598490.1_Silent_p.A41A			A6NJB7	PRR19_HUMAN	proline rich 19	41										NS(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	10		Prostate(69;0.00682)				GGCCATTAGCCCACCACGATC	0.647000													20	29					0	0	0.001523	0	0
BRF1	2972	broad.mit.edu	37	14	105685585	105685585	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:105685585G>A	ENST00000440513.3	-	13	1511	c.1083C>T	c.(1081-1083)ttC>ttT	p.F361F	BRF1_ENST00000551787.1_Intron|BRF1_ENST00000549044.1_Intron|BRF1_ENST00000379932.4_Intron|BRF1_ENST00000547530.1_Intron|BRF1_ENST00000446501.2_Intron|BRF1_ENST00000392557.4_Intron|BRF1_ENST00000379937.2_Intron|BRF1_ENST00000546474.1_Intron|BRF1_ENST00000327359.3_Intron	NM_001242786.1	NP_001229715.1	Q92994	TF3B_HUMAN	BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit	459					positive regulation of transcription, DNA-dependent|rRNA transcription|transcription initiation from RNA polymerase III promoter|tRNA transcription	transcription factor TFIIIB complex	translation initiation factor activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|skin(2)|urinary_tract(2)	24		all_cancers(154;0.0231)|all_epithelial(191;0.0694)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00753)|all cancers(16;0.00925)|Epithelial(46;0.0221)	Epithelial(152;0.14)		CGAGCACAGGGAAGTGGGGCT	0.622000													16	16					0	0	0.004007	0	0
GIT2	9815	broad.mit.edu	37	12	110429562	110429562	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:110429562G>A	ENST00000360185.4	-	2	220	c.56C>T	c.(55-57)cCt>cTt	p.P19L	GIT2_ENST00000338373.5_Missense_Mutation_p.P19L|GIT2_ENST00000551209.1_Missense_Mutation_p.P19L|GIT2_ENST00000457474.2_Missense_Mutation_p.P19L|GIT2_ENST00000355312.3_Missense_Mutation_p.P19L|GIT2_ENST00000320063.9_Missense_Mutation_p.P19L|GIT2_ENST00000553118.1_Missense_Mutation_p.P19L|GIT2_ENST00000356259.4_Missense_Mutation_p.P19L|GIT2_ENST00000343646.5_Missense_Mutation_p.P19L|GIT2_ENST00000361006.5_Missense_Mutation_p.P19L|GIT2_ENST00000547815.1_Missense_Mutation_p.P19L|GIT2_ENST00000354574.4_Missense_Mutation_p.P19L			Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting ArfGAP 2	19	Arf-GAP.				regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(8)|skin(4)	27						TGCCCAGGAAGGATCTGGAAA	0.478000													16	48					0	0	0.007413	0	0
UBD	10537	broad.mit.edu	37	6	29523759	29523759	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:29523759C>T	ENST00000377050.4	-	2	619	c.396G>A	c.(394-396)gtG>gtA	p.V132V	GABBR1_ENST00000355973.3_3'UTR	NM_006398.3	NP_006389.2	O15205	UBD_HUMAN	ubiquitin D	132	Ubiquitin 2.				aggresome assembly|myeloid dendritic cell differentiation|negative regulation of mitotic prometaphase|positive regulation of apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein ubiquitination|response to interferon-gamma|response to tumor necrosis factor|ubiquitin-dependent protein catabolic process	aggresome|cytoplasm|nucleus	proteasome binding			kidney(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	6						CATTGCAAGTCACAATCTGGG	0.488000													30	114					0	0	0.001512	0	0
C6orf15	29113	broad.mit.edu	37	6	31079437	31079437	+	Silent	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31079437T>G	ENST00000259870.3	-	2	702	c.699A>C	c.(697-699)ccA>ccC	p.P233P		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	233	Gly-rich.									endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						CCTCAGGGTGTGGCATGGGCC	0.567000													25	87					0	0	0.003954	0	0
COL17A1	1308	broad.mit.edu	37	10	105798213	105798213	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:105798213G>A	ENST00000353479.5	-	45	3311	c.3021C>T	c.(3019-3021)atC>atT	p.I1007I	COL17A1_ENST00000369733.3_Silent_p.I962I	NM_000494.3	NP_000485.3	Q9UMD9	COHA1_HUMAN	collagen, type XVII, alpha 1	1007	Triple-helical region.				cell-matrix adhesion|epidermis development|hemidesmosome assembly	basement membrane|cell-cell junction|collagen|hemidesmosome|integral to plasma membrane	protein binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(9)|liver(1)|lung(22)|ovary(5)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	62		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;2.5e-09)|all cancers(201;7.94e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		CAGAGCTGCTGATAGAGCCCG	0.597000													106	59					0	0	0.003610	0	0
GOLGB1	2804	broad.mit.edu	37	3	121416026	121416026	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:121416026A>T	ENST00000393667.3	-	13	3454	c.3344T>A	c.(3343-3345)tTg>tAg	p.L1115*	GOLGB1_ENST00000340645.5_Nonsense_Mutation_p.L1110*	NM_001256486.1	NP_001243415.1	Q14789	GOGB1_HUMAN	golgin B1	1110					Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(2)|cervix(2)|endometrium(12)|kidney(3)|large_intestine(26)|liver(2)|lung(36)|ovary(7)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(13)	119				GBM - Glioblastoma multiforme(114;0.0989)		TGCTTGGAGCAAATCTATTTG	0.418000													38	88					0	0	0.004289	0	0
MYH4	4622	broad.mit.edu	37	17	10355446	10355446	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:10355446C>T	ENST00000255381.2	-	27	3660	c.3550G>A	c.(3550-3552)Gag>Aag	p.E1184K	CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA|CTC-297N7.7_ENST00000399342.2_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	1184					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						AGGGTGGACTCTTCCAGGTCC	0.587000													31	39					0	0	0.001786	0	0
ANK3	288	broad.mit.edu	37	10	61835777	61835777	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:61835777G>A	ENST00000280772.1	-	37	5053	c.4862C>T	c.(4861-4863)tCc>tTc	p.S1621F	ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron|ANK3_ENST00000503366.1_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	1621	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						GGTTCGAGAGGAAAACGTAGA	0.478000													24	32					0	0	0.003954	0	0
SLCO1A2	6579	broad.mit.edu	37	12	21457412	21457412	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:21457412T>C	ENST00000307378.6	-	7	1258	c.538A>G	c.(538-540)Att>Gtt	p.I180V	SLCO1A2_ENST00000458504.1_Missense_Mutation_p.I48V|SLCO1A2_ENST00000390670.3_Missense_Mutation_p.I178V|SLCO1A2_ENST00000452078.1_Missense_Mutation_p.I180V|SLCO1A2_ENST00000537524.1_Missense_Mutation_p.I48V	NM_134431.3	NP_602307.1	P46721	SO1A2_HUMAN	solute carrier organic anion transporter family, member 1A2	180					bile acid metabolic process|sodium-independent organic anion transport	integral to membrane|plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(2)|endometrium(2)|kidney(4)|large_intestine(8)|lung(23)|ovary(1)|pancreas(1)|skin(6)|upper_aerodigestive_tract(1)	48						ATATAGGAAATACCCAAAGGC	0.368000													15	26					0	0	0.002450	0	0
TTN	7273	broad.mit.edu	37	2	179501144	179501144	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:179501144C>T	ENST00000589042.1	-	225	41534	c.41310G>A	c.(41308-41310)acG>acA	p.T13770T	TTN_ENST00000359218.5_Silent_p.T4830T|TTN-AS1_ENST00000589487.1_RNA|TTN_ENST00000342175.6_Silent_p.T4897T|TTN_ENST00000591111.1_Silent_p.T12129T|TTN_ENST00000460472.2_Silent_p.T4705T|TTN_ENST00000342992.6_Silent_p.T11202T|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000589830.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	12129	Ig-like 94.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAGTTTAGCCGTGGAGGTCT	0.353000													13	17					0	0	0.001368	0	0
RIPK3	11035	broad.mit.edu	37	14	24808511	24808511	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:24808511C>T	ENST00000216274.5	-	3	399	c.181G>A	c.(181-183)Gtc>Atc	p.V61I	RIPK3_ENST00000554338.1_5'UTR	NM_006871.3	NP_006862.2	Q9Y572	RIPK3_HUMAN	receptor-interacting serine-threonine kinase 3	61	Protein kinase.				apoptosis|induction of apoptosis by extracellular signals	cytoplasm	ATP binding|protein binding|transcription coactivator activity			NS(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				GBM - Glioblastoma multiforme(265;0.0181)		ATGGCCTTGACCTCCCTGGAT	0.582000													30	38					0	0	0.002445	0	0
MYO18B	84700	broad.mit.edu	37	22	26242247	26242247	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:26242247G>A	ENST00000335473.7	+	19	3799	c.3549G>A	c.(3547-3549)caG>caA	p.Q1183Q	MYO18B_ENST00000407587.2_Silent_p.Q1184Q|MYO18B_ENST00000536101.1_Silent_p.Q1183Q	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1183	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						TCAAGCTGCAGATGGTGAGTG	0.612000													17	28					0	0	0.001523	0	0
SEMA4A	64218	broad.mit.edu	37	1	156127865	156127865	+	Missense_Mutation	SNP	C	C	T	rs143382589		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:156127865C>T	ENST00000368285.3	+	4	572	c.305C>T	c.(304-306)cCg>cTg	p.P102L	SEMA4A_ENST00000368284.1_Missense_Mutation_p.P3L|SEMA4A_ENST00000368282.1_Missense_Mutation_p.P102L|SEMA4A_ENST00000368286.2_Missense_Mutation_p.P3L|SEMA4A_ENST00000355014.2_Missense_Mutation_p.P102L|SEMA4A_ENST00000487358.1_3'UTR	NM_001193300.1|NM_022367.3	NP_001180229.1|NP_071762.2	Q9H3S1	SEM4A_HUMAN	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	102	Sema.				axon guidance	integral to membrane|plasma membrane	receptor activity			breast(1)|ovary(2)|skin(2)	5	Hepatocellular(266;0.158)					TTTCAGATACCGTGGCCAGCC	0.498000													11	43					0	0	0.000978	0	0
MFSD7	84179	broad.mit.edu	37	4	679631	679631	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:679631G>A	ENST00000322224.4	-	4	891	c.578C>T	c.(577-579)cCg>cTg	p.P193L	MFSD7_ENST00000515118.1_Intron|MFSD7_ENST00000404286.2_Missense_Mutation_p.P193L|MFSD7_ENST00000347950.5_Intron|MFSD7_ENST00000503156.1_Missense_Mutation_p.P129L			Q6UXD7	MFSD7_HUMAN	major facilitator superfamily domain containing 7	193					transmembrane transport	integral to membrane				cervix(1)|kidney(2)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	11						CACCATTAACGGAATGTCCTC	0.587000													15	73					0	0	0.004007	0	0
CSMD3	114788	broad.mit.edu	37	8	113599463	113599463	+	Splice_Site	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:113599463A>C	ENST00000297405.5	-	23	3961	c.3715_splice	c.e23-1	p.A1239_splice	CSMD3_ENST00000352409.3_Splice_Site_p.A1239_splice|CSMD3_ENST00000343508.3_Splice_Site_p.A1199_splice|CSMD3_ENST00000455883.2_Splice_Site_p.A1135_splice	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	1239	Sushi 6.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						CACCACATTCAGCTGCAGGTA	0.328000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			14	105					0	0	0.003163	0	0
LTBP4	8425	broad.mit.edu	37	19	41129549	41129549	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:41129549G>A	ENST00000308370.7	+	29	3795	c.3795G>A	c.(3793-3795)aaG>aaA	p.K1265K	LTBP4_ENST00000204005.9_Silent_p.K1228K|LTBP4_ENST00000602240.1_3'UTR|LTBP4_ENST00000545697.1_Silent_p.K633K|LTBP4_ENST00000396819.3_Silent_p.K1198K|LTBP4_ENST00000243562.9_3'UTR	NM_001042544.1	NP_001036009.1	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding protein 4	1266	EGF-like 13; calcium-binding (Potential).				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGGTGTGCAAGAGTGGCGTGT	0.592000													10	11					0	0	0.000673	0	0
ZNF99	7652	broad.mit.edu	37	19	22951111	22951111	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:22951111G>A	ENST00000397104.3	-	3	284	c.285C>T	c.(283-285)ccC>ccT	p.P95P	ZNF99_ENST00000596209.1_Silent_p.P74P					zinc finger protein 99											NS(1)|breast(1)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(20)|lung(55)|ovary(2)|prostate(10)|skin(5)|stomach(9)|upper_aerodigestive_tract(2)|urinary_tract(3)	124		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				ACATACCTGGGGGTTTAGTTA	0.433000													9	11					0	0	0.006214	0	0
ALKBH7	84266	broad.mit.edu	37	19	6374273	6374273	+	Translation_Start_Site	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:6374273C>A	ENST00000596657.1	+	0	147				ALKBH7_ENST00000245812.3_Silent_p.I88I|ALKBH7_ENST00000599849.1_Silent_p.I27I			Q9BT30	ALKB7_HUMAN	alkB, alkylation repair homolog 7 (E. coli)							extracellular region|nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|kidney(1)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6						GCCGGGCCATCCTGCAGCGCG	0.682000													18	18					3.51602e-12	5.992e-12	0.001216	1	0
RSPO1	284654	broad.mit.edu	37	1	38078451	38078451	+	Silent	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:38078451T>C	ENST00000356545.2	-	8	1555	c.768A>G	c.(766-768)ccA>ccG	p.P256P	RSPO1_ENST00000401069.1_Silent_p.P256P|RSPO1_ENST00000373059.1_Silent_p.P229P|RSPO1_ENST00000401071.2_Silent_p.P193P|RSPO1_ENST00000401070.1_Silent_p.P193P|RSPO1_ENST00000401068.1_Silent_p.P256P	NM_001038633.3	NP_001033722.1	Q2MKA7	RSPO1_HUMAN	R-spondin 1	256					positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(3)|lung(5)	12		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CAGATGTGAGTGGCCCCACTG	0.602000													32	99					0	0	0.002096	0	0
CFB	629	broad.mit.edu	37	6	31918170	31918170	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31918170G>A	ENST00000456570.1	+	24	3175	c.3120G>A	c.(3118-3120)aaG>aaA	p.K1040K	CFB_ENST00000477310.1_Silent_p.K889K|CFB_ENST00000425368.2_Silent_p.K538K|CFB_ENST00000556679.1_Silent_p.K1040K			P00751	CFAB_HUMAN	complement factor B	538					complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						ACTCAATCAAGGTCAGCGTAG	0.522000													114	780					0	0	0.003610	0	0
PLEKHA4	57664	broad.mit.edu	37	19	49364692	49364692	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:49364692G>A	ENST00000263265.6	-	5	887	c.332C>T	c.(331-333)cCg>cTg	p.P111L	PLEKHA4_ENST00000355496.5_Missense_Mutation_p.P111L	NM_020904.2	NP_065955.2	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4	111	PH.					cytoplasm|membrane	1-phosphatidylinositol binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(3)|skin(2)|urinary_tract(2)	30		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		GGGGGCTCCCGGCCCATCTGG	0.607000													34	50					0	0	0.006230	0	0
SCUBE2	57758	broad.mit.edu	37	11	9074719	9074719	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:9074719G>A	ENST00000457346.2	-	12	1448	c.1374C>T	c.(1372-1374)tcC>tcT	p.S458S	SCUBE2_ENST00000450649.2_Intron|SCUBE2_ENST00000520467.1_Silent_p.S458S|SCUBE2_ENST00000309263.3_Silent_p.S458S|RP11-467K18.2_ENST00000531592.1_RNA			Q9NQ36	SCUB2_HUMAN	signal peptide, CUB domain, EGF-like 2	458						extracellular region	calcium ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(15)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		CGCAGTGCAGGGACACACGGG	0.552000													11	22					0	0	0.000978	0	0
LILRP2	79166	broad.mit.edu	37	19	55221329	55221329	+	RNA	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55221329T>A	ENST00000413439.1	+	0	1118																											CGACTCTTCTTTCCCTCCAGG	0.627000													8	12					0	0	0.006214	0	0
DNAH10	196385	broad.mit.edu	37	12	124377950	124377950	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:124377950G>A	ENST00000409039.3	+	52	8837	c.8812G>A	c.(8812-8814)Gac>Aac	p.D2938N		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2938	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		GCCAGTGGGGGACACCCTGAG	0.582000													26	66					0	0	0.001786	0	0
TPCN1	53373	broad.mit.edu	37	12	113717964	113717964	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:113717964A>G	ENST00000550785.1	+	16	1691	c.1522A>G	c.(1522-1524)Atc>Gtc	p.I508V	TPCN1_ENST00000335509.6_Missense_Mutation_p.I436V|TPCN1_ENST00000541517.1_Missense_Mutation_p.I508V|TPCN1_ENST00000392569.4_Missense_Mutation_p.I368V	NM_001143819.1	NP_001137291.1	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1	436						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						AGGTATTAATATCCTTGTGAA	0.393000													16	54					0	0	0.001216	0	0
CRY1	1407	broad.mit.edu	37	12	107391385	107391385	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:107391385G>A	ENST00000008527.5	-	9	2240	c.1373C>T	c.(1372-1374)gCc>gTc	p.A458V		NM_004075.3	NP_004066.1	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	458	FAD-binding.|Required for inhibition of CLOCK-ARNTL- mediated transcription (By similarity).				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|skin(1)	29						CAAACATTTGGCTACCTTTTG	0.413000													16	60					0	0	0.006122	0	0
KRT25	147183	broad.mit.edu	37	17	38910165	38910165	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:38910165G>A	ENST00000312150.4	-	3	676	c.616C>T	c.(616-618)Cag>Tag	p.Q206*		NM_181534.3	NP_853512.1	Q7Z3Z0	K1C25_HUMAN	keratin 25	206	Coil 1B.|Rod.					cytoplasm|intermediate filament	structural molecule activity			endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|prostate(4)	16		Breast(137;0.00526)				GTTTCATACTGAATCTCCAGA	0.448000													84	57					0	0	0.003610	0	0
TMEM105	284186	broad.mit.edu	37	17	79287651	79287651	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:79287651G>A	ENST00000332900.1	-	3	739	c.190C>T	c.(190-192)Cct>Tct	p.P64S		NM_178520.3	NP_848615.1	Q8N8V8	TM105_HUMAN	transmembrane protein 105	64						integral to membrane				NS(1)|large_intestine(3)|lung(1)|ovary(2)	7	all_neural(118;0.0804)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0272)|OV - Ovarian serous cystadenocarcinoma(97;0.0892)			TCCCCCCAAGGAGACCGAGGT	0.622000													56	33					0	0	0.003610	0	0
LHX2	9355	broad.mit.edu	37	9	126783392	126783392	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:126783392G>A	ENST00000373615.4	+	4	1481	c.742G>A	c.(742-744)Gaa>Aaa	p.E248K		NM_004789.3	NP_004780.3	P50458	LHX2_HUMAN	LIM homeobox 2	248						nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)	10						AAGCTGCAACGAAAACGACGC	0.612000													16	3					0	0	0.004990	0	0
TUBE1	51175	broad.mit.edu	37	6	112397626	112397626	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:112397626G>A	ENST00000368662.5	-	7	613	c.535C>T	c.(535-537)Cct>Tct	p.P179S	TUBE1_ENST00000604814.1_5'UTR	NM_016262.4	NP_057346.1	Q9UJT0	TBE_HUMAN	tubulin, epsilon 1	179					centrosome cycle|microtubule-based movement|protein polymerization	microtubule|pericentriolar material	GTP binding|GTPase activity|structural constituent of cytoskeleton			cervix(1)|endometrium(2)|large_intestine(5)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	12		all_cancers(87;0.0101)|all_hematologic(75;0.000258)|Colorectal(196;0.0466)|all_epithelial(87;0.1)		all cancers(137;0.0217)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0636)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		TCACCAGAAGGATAAATGGAA	0.398000													26	20					0	0	0.003954	0	0
SHH	6469	broad.mit.edu	37	7	155596398	155596398	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:155596398C>T	ENST00000297261.2	-	3	735	c.585G>A	c.(583-585)tcG>tcA	p.S195S		NM_000193.2	NP_000184.1	Q15465	SHH_HUMAN	sonic hedgehog	195					androgen metabolic process|axon guidance|branching involved in ureteric bud morphogenesis|CD4-positive or CD8-positive, alpha-beta T cell lineage commitment|embryonic digit morphogenesis|hindbrain development|intein-mediated protein splicing|lymphoid progenitor cell differentiation|metanephric mesenchymal cell proliferation involved in metanephros development|midbrain development|negative regulation of cell migration|negative regulation of kidney smooth muscle cell differentiation|negative regulation of ureter smooth muscle cell differentiation|negative thymic T cell selection|neural crest cell migration|neuroblast proliferation|patterning of blood vessels|positive regulation of alpha-beta T cell differentiation|positive regulation of immature T cell proliferation in thymus|positive regulation of kidney smooth muscle cell differentiation|positive regulation of mesenchymal cell proliferation involved in ureter development|positive regulation of T cell differentiation in thymus|positive regulation of ureter smooth muscle cell differentiation|positive thymic T cell selection|proteolysis|sclerotome development|stem cell development|thymus development|vasculogenesis|ventral midline development	cell surface|extracellular space|membrane raft|plasma membrane	calcium ion binding|laminin-1 binding|peptidase activity|signal transducer activity|zinc ion binding			central_nervous_system(3)|kidney(1)|large_intestine(1)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	14	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.00882)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		AGCAGCCTCCCGATTTGGCCG	0.692000													5	7					0	0	0.001168	0	0
TG	7038	broad.mit.edu	37	8	133900623	133900623	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:133900623C>T	ENST00000220616.4	+	10	2611	c.2571C>T	c.(2569-2571)ccC>ccT	p.P857P	TG_ENST00000377869.1_Silent_p.P857P	NM_003235.4	NP_003226.4	P01266	THYG_HUMAN	thyroglobulin	857	Thyroglobulin type-1 7.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGCCCCAGCCCAGGGAGAATA	0.552000													11	83					0	0	0.001368	0	0
GPR179	440435	broad.mit.edu	37	17	36499518	36499518	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:36499518G>A	ENST00000342292.4	-	1	175	c.155C>T	c.(154-156)cCc>cTc	p.P52L		NM_001004334.2	NP_001004334.2	Q6PRD1	GP179_HUMAN	G protein-coupled receptor 179	52						integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(4)|cervix(2)|endometrium(9)|kidney(3)|large_intestine(16)|lung(15)|ovary(4)|pancreas(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	60	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				CCCCTCTAGGGGCACCTGCAT	0.617000													33	19					0	0	0.006230	0	0
ZNF154	7710	broad.mit.edu	37	19	58213273	58213273	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:58213273C>T	ENST00000512439.2	-	3	1240	c.1044G>A	c.(1042-1044)cgG>cgA	p.R348R	AC003006.7_ENST00000596085.1_Intron|AC003006.7_ENST00000599221.1_Intron|ZNF154_ENST00000426889.1_Silent_p.R348R			Q13106	ZN154_HUMAN	zinc finger protein 154	348						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(7)|lung(3)	12		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TGTGAACTCCCCGATGTTGAA	0.498000													23	64					0	0	0.002299	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92459306	92459306	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:92459306G>A	ENST00000318445.6	+	2	478	c.264G>A	c.(262-264)ggG>ggA	p.G88G	SLCO3A1_ENST00000424469.2_Silent_p.G88G	NM_013272.3	NP_037404.2	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family, member 3A1	88					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			TCGAGATCGGGAACCTGGCGC	0.672000													18	24					0	0	0.001216	0	0
TMEM68	137695	broad.mit.edu	37	8	56663611	56663611	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:56663611A>T	ENST00000434581.2	-	5	798	c.599T>A	c.(598-600)gTt>gAt	p.V200D	TMEM68_ENST00000519784.1_Missense_Mutation_p.V86D|TMEM68_ENST00000334667.2_Missense_Mutation_p.V200D|TMEM68_ENST00000523073.1_Missense_Mutation_p.V86D			Q96MH6	TMM68_HUMAN	transmembrane protein 68	200						integral to membrane	acyltransferase activity			NS(1)|kidney(1)|lung(2)|ovary(1)|skin(1)	6			Epithelial(17;0.000361)|all cancers(17;0.00326)			GGCTTCTCGAACTCCACCTGG	0.413000													18	93					0	0	0.007413	0	0
EVPL	2125	broad.mit.edu	37	17	74015056	74015056	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:74015056C>T	ENST00000301607.3	-	11	1476	c.1223G>A	c.(1222-1224)cGa>cAa	p.R408Q	EVPL_ENST00000586740.1_Missense_Mutation_p.R408Q	NM_001988.2	NP_001979.2	Q92817	EVPL_HUMAN	envoplakin	408	Globular 1.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			breast(4)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(2)|pancreas(2)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	54						GGGGTTTCTTCGCTGTGGCAG	0.682000													21	11					0	0	0.001882	0	0
DVL2	1856	broad.mit.edu	37	17	7132931	7132931	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:7132931C>T	ENST00000005340.5	-	6	1005	c.723G>A	c.(721-723)aaG>aaA	p.K241K	DVL2_ENST00000574642.1_5'UTR|DVL2_ENST00000575458.1_Silent_p.K235K	NM_004422.2	NP_004413.1	O14641	DVL2_HUMAN	dishevelled segment polarity protein 2	241					canonical Wnt receptor signaling pathway involved in regulation of cell proliferation|intracellular signal transduction|neural tube closure|positive regulation of JUN kinase activity|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|segment specification|transcription from RNA polymerase II promoter	cytosol|nucleus|plasma membrane	frizzled binding|identical protein binding|signal transducer activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(11)|lung(7)|skin(1)	25						GTGGCCTCTGCTTCCTTCGCC	0.647000													22	41					0	0	0.002780	0	0
ADAM12	8038	broad.mit.edu	37	10	127755327	127755327	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:127755327C>T	ENST00000368679.4	-	13	1690	c.1381G>A	c.(1381-1383)Gac>Aac	p.D461N	ADAM12_ENST00000368676.4_Missense_Mutation_p.D461N|ADAM12_ENST00000467145.1_5'UTR	NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	461	Disintegrin.				cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding			biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		CACACAGCGTCCGGCTTCAGG	0.547000													11	18					0	0	0.000978	0	0
ZZEF1	23140	broad.mit.edu	37	17	3937384	3937384	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:3937384C>T	ENST00000381638.2	-	40	6633	c.6509G>A	c.(6508-6510)gGg>gAg	p.G2170E		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	2170							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						GGAACTGTCCCCTGCAGCAAA	0.542000													40	62					0	0	0.003610	0	0
SCN4A	6329	broad.mit.edu	37	17	62019354	62019354	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:62019354C>T	ENST00000435607.1	-	24	4365		c.e24-1		SCN4A_ENST00000578147.1_Splice_Site	NM_000334.4	NP_000325.4	P35499	SCN4A_HUMAN	sodium channel, voltage-gated, type IV, alpha subunit						muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(4)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(23)|lung(40)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	101					Lamotrigine(DB00555)	AGGGCAAGGCCTGCGGGGAGA	0.682000													4	10					0	0	0.001168	0	0
PCDH15	65217	broad.mit.edu	37	10	55944921	55944921	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:55944921C>T	ENST00000373965.2	-	13	1828	c.1434G>A	c.(1432-1434)agG>agA	p.R478R	PCDH15_ENST00000395440.1_Intron|PCDH15_ENST00000361849.3_Silent_p.R471R|PCDH15_ENST00000414778.1_Silent_p.R476R|PCDH15_ENST00000395433.1_Silent_p.R449R|PCDH15_ENST00000409834.1_Silent_p.R82R|PCDH15_ENST00000395432.2_Silent_p.R434R|PCDH15_ENST00000373955.1_Silent_p.R471R|PCDH15_ENST00000437009.1_Silent_p.R471R|PCDH15_ENST00000320301.6_Silent_p.R471R|PCDH15_ENST00000395438.1_Silent_p.R471R|PCDH15_ENST00000395445.1_Silent_p.R478R|PCDH15_ENST00000395430.1_Silent_p.R471R|PCDH15_ENST00000395446.1_Silent_p.R471R|PCDH15_ENST00000373957.3_Silent_p.R449R|PCDH15_ENST00000395442.1_Intron	NM_001142771.1|NM_001142772.1	NP_001136243.1|NP_001136244.1	Q96QU1	PCD15_HUMAN	protocadherin-related 15	471	Cadherin 4.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			NS(3)|breast(6)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(39)|lung(108)|ovary(5)|pancreas(6)|prostate(6)|skin(12)|upper_aerodigestive_tract(12)|urinary_tract(1)	237		Melanoma(3;0.117)|Lung SC(717;0.238)				GCTGTTCTTCCCTGTCCACTG	0.398000										HNSCC(58;0.16)			25	26					0	0	0.004656	0	0
OR51B6	390058	broad.mit.edu	37	11	5373580	5373580	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:5373580C>T	ENST00000380219.1	+	1	843	c.843C>T	c.(841-843)ttC>ttT	p.F281F	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380259.2_Intron|AC104389.28_ENST00000415970.1_RNA|HBG2_ENST00000380252.1_Intron	NM_001004750.1	NP_001004750.1	Q9H340	O51B6_HUMAN	olfactory receptor, family 51, subfamily B, member 6	281					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.F281F(1)		central_nervous_system(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	21		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		ACTTCCTTTTCCCACCTTTTA	0.383000													26	50					0	0	0.003330	0	0
OR10J1	26476	broad.mit.edu	37	1	159409836	159409836	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:159409836C>T	ENST00000423932.3	+	1	325	c.288C>T	c.(286-288)ctC>ctT	p.L96L	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	96					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					TCTCCAGCCTCGTAGGTATGA	0.468000													50	27					0	0	0.003610	0	0
SCN5A	6331	broad.mit.edu	37	3	38622667	38622667	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:38622667G>A	ENST00000413689.1	-	17	3176	c.2983C>T	c.(2983-2985)Ctt>Ttt	p.L995F	SCN5A_ENST00000425664.1_Missense_Mutation_p.L995F|SCN5A_ENST00000443581.1_Missense_Mutation_p.L995F|SCN5A_ENST00000423572.2_Missense_Mutation_p.L995F|SCN5A_ENST00000449557.2_Missense_Mutation_p.L995F|SCN5A_ENST00000414099.2_Missense_Mutation_p.L995F|SCN5A_ENST00000450102.2_Missense_Mutation_p.L995F|SCN5A_ENST00000451551.2_Missense_Mutation_p.L995F|SCN5A_ENST00000455624.2_Missense_Mutation_p.L995F|SCN5A_ENST00000333535.4_Missense_Mutation_p.L995F	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	995					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity			NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	TGGGCGGCAAGGGCTGCGGGC	0.687000													4	17					0	0	0.000248	0	0
ARHGEF16	27237	broad.mit.edu	37	1	3390083	3390083	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:3390083G>A	ENST00000378378.4	+	8	1707	c.1302G>A	c.(1300-1302)atG>atA	p.M434I	ARHGEF16_ENST00000413250.2_Missense_Mutation_p.M138I|ARHGEF16_ENST00000378373.1_Missense_Mutation_p.M146I|ARHGEF16_ENST00000378371.2_Missense_Mutation_p.M146I	NM_014448.3	NP_055263.2	Q5VV41	ARHGG_HUMAN	Rho guanine nucleotide exchange factor (GEF) 16	434	DH.|Required for RHOG activation and mediates interaction with EPHA2.				activation of Cdc42 GTPase activity|activation of Rac GTPase activity|apoptosis|cell chemotaxis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|small GTPase mediated signal transduction	cytosol	PDZ domain binding|receptor tyrosine kinase binding|Rho GTPase binding|Rho guanyl-nucleotide exchange factor activity			lung(6)|ovary(1)	7	all_cancers(77;0.00276)|all_epithelial(69;0.00102)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.101)	all_epithelial(116;7.14e-21)|all_lung(118;2.24e-08)|Lung NSC(185;3.55e-06)|Breast(487;0.000765)|Renal(390;0.00121)|Hepatocellular(190;0.0046)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.211)		Epithelial(90;8.62e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.62e-22)|GBM - Glioblastoma multiforme(42;2.49e-12)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.000681)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		CCCTCCTGATGGATGTAAGTC	0.672000													15	67					0	0	0.004990	0	0
FAT4	79633	broad.mit.edu	37	4	126411747	126411747	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:126411747C>T	ENST00000394329.3	+	17	13783	c.13770C>T	c.(13768-13770)taC>taT	p.Y4590Y	FAT4_ENST00000335110.5_Silent_p.Y2831Y	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4590					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AAAACCCCTACCTTATCTATG	0.473000													28	23					0	0	0.006320	0	0
UNK	85451	broad.mit.edu	37	17	73805988	73805988	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:73805988C>T	ENST00000293218.3	+	3	480	c.480C>T	c.(478-480)taC>taT	p.Y160Y	UNK_ENST00000589666.1_Silent_p.Y84Y			Q9C0B0	UNK_HUMAN	unkempt family zinc finger	84							nucleic acid binding|zinc ion binding			cervix(3)|endometrium(8)|kidney(2)|large_intestine(5)|lung(3)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	25			all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCTTCAATTACAGCCCTGACG	0.642000													40	24					0	0	0.007835	0	0
SPAG17	200162	broad.mit.edu	37	1	118567984	118567984	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:118567984G>A	ENST00000336338.5	-	27	3851	c.3786C>T	c.(3784-3786)taC>taT	p.Y1262Y		NM_206996.2	NP_996879.1	Q6Q759	SPG17_HUMAN	sperm associated antigen 17	1262						cilium|flagellar axoneme|microtubule				NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(30)|liver(2)|lung(56)|ovary(3)|prostate(5)|skin(5)|upper_aerodigestive_tract(6)|urinary_tract(1)	123	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		CCCTCTGGGGGTAGCTCTGAC	0.473000													32	80					0	0	0.006230	0	0
IGSF10	285313	broad.mit.edu	37	3	151155730	151155730	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:151155730C>T	ENST00000282466.3	-	6	6618	c.6619G>A	c.(6619-6621)Gat>Aat	p.D2207N	IGSF10_ENST00000495443.1_5'UTR	NM_001178145.1|NM_001178146.1|NM_178822.4	NP_001171616.1|NP_001171617.1|NP_849144.2	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10	2207	Ig-like C2-type 8.				cell differentiation|multicellular organismal development|ossification	extracellular region				NS(1)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(24)|liver(4)|lung(43)|ovary(8)|prostate(4)|skin(9)|stomach(1)|urinary_tract(3)	116			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TCTCCAGAATCGAGCAGTTTC	0.428000													23	67					0	0	0.005443	0	0
FOXI2	399823	broad.mit.edu	37	10	129537088	129537088	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:129537088C>T	ENST00000388920.4	+	2	855	c.816C>T	c.(814-816)ttC>ttT	p.F272F		NM_207426.2	NP_997309.2	Q6ZQN5	FOXI2_HUMAN	forkhead box I2	272					epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			large_intestine(1)|lung(3)	4		all_epithelial(44;0.0021)|all_lung(145;0.0586)|Lung NSC(174;0.0765)|all_neural(114;0.201)|Glioma(114;0.222)				ACTTTTCTTTCGGGAGGCGGC	0.716000													4	8					0	0	0.000248	0	0
HMCN1	83872	broad.mit.edu	37	1	186083184	186083184	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:186083184C>T	ENST00000271588.4	+	73	11434	c.11205C>T	c.(11203-11205)atC>atT	p.I3735I	HMCN1_ENST00000367492.2_Silent_p.I3735I	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3735	Ig-like C2-type 36.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						TGGAATGCATCGCTGAAGGTG	0.408000													82	93					0	0	0.003610	0	0
C6orf25	80739	broad.mit.edu	37	6	31692559	31692559	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31692559G>A	ENST00000375809.3	+	5	589	c.578G>A	c.(577-579)cGa>cAa	p.R193Q	C6orf25_ENST00000480039.1_Missense_Mutation_p.E187K|C6orf25_ENST00000375805.2_Missense_Mutation_p.E163K|C6orf25_ENST00000375810.4_Missense_Mutation_p.R193Q	NM_025260.3|NM_138272.2|NM_138277.2	NP_079536.2|NP_612116.1|NP_612121.1	O95866	G6B_HUMAN	chromosome 6 open reading frame 25	0						endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	heparin binding|receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)	9						TGTGAAAACCGAGCCCCAGAG	0.572000													72	482					0	0	0.003610	0	0
DNAH3	55567	broad.mit.edu	37	16	20975684	20975684	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:20975684G>A	ENST00000261383.3	-	53	9521	c.9522C>T	c.(9520-9522)acC>acT	p.T3174T	DNAH3_ENST00000415178.1_3'UTR	NM_017539.1	NP_060009.1	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	3174	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(3)|autonomic_ganglia(1)|breast(12)|central_nervous_system(3)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(42)|liver(2)|lung(57)|ovary(14)|pancreas(1)|prostate(7)|skin(11)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(6)	202				GBM - Glioblastoma multiforme(48;0.207)		TCCTCAAACGGGTTGTGATGT	0.453000													31	50					0	0	0.001512	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103433413	103433413	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:103433413C>T	ENST00000361246.2	-	17	2729	c.2441G>A	c.(2440-2442)tGg>tAg	p.W814*		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	814					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		CTGAGCTTCCCAGTGGGCCAC	0.562000													22	21					0	0	0.003330	0	0
HMP19	51617	broad.mit.edu	37	5	173531337	173531337	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:173531337A>T	ENST00000303177.3	+	4	582	c.320A>T	c.(319-321)tAt>tTt	p.Y107F	NSG2_ENST00000521585.1_Intron|NSG2_ENST00000521959.1_3'UTR	NM_015980.4	NP_057064.1																					GGATTCGTCTATAAGGTAAGA	0.478000													13	46					0	0	0.004007	0	0
ADAD2	161931	broad.mit.edu	37	16	84227702	84227702	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:84227702G>A	ENST00000268624.3	+	2	602	c.509G>A	c.(508-510)aGa>aAa	p.R170K	RP11-486L19.2_ENST00000565643.1_RNA|RP11-486L19.2_ENST00000536986.1_RNA|ADAD2_ENST00000315906.5_Intron	NM_139174.3	NP_631913.3	Q8NCV1	ADAD2_HUMAN	adenosine deaminase domain containing 2	0	DRBM.				RNA processing	intracellular	adenosine deaminase activity|double-stranded RNA binding			NS(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|prostate(2)|skin(1)	13						TTCCTCCTGAGAACAGGGTGg	0.522000													23	36					0	0	0.001882	0	0
CFB	629	broad.mit.edu	37	6	31911475	31911475	+	Missense_Mutation	SNP	C	C	T	rs143869308		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31911475C>T	ENST00000456570.1	+	10	1218	c.1163C>T	c.(1162-1164)tCc>tTc	p.S388F	C2_ENST00000442278.2_Missense_Mutation_p.S409F|C2_ENST00000452323.2_Missense_Mutation_p.S327F|C2_ENST00000469372.1_Missense_Mutation_p.S295F|CFB_ENST00000477310.1_Missense_Mutation_p.S312F|C2_ENST00000468407.1_3'UTR|CFB_ENST00000556679.1_Missense_Mutation_p.S388F|C2_ENST00000299367.5_Missense_Mutation_p.S541F			P00751	CFAB_HUMAN	complement factor B	556	VWFA.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						GCGGTGATCTCCCCAGGGTTT	0.498000													146	977					0	0	0.003610	0	0
HSF1	3297	broad.mit.edu	37	8	145535766	145535766	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:145535766C>T	ENST00000528838.1	+	9	1138	c.978C>T	c.(976-978)tcC>tcT	p.S326S	HSF1_ENST00000400780.4_Silent_p.S261S	NM_005526.2	NP_005517.1	Q00613	HSF1_HUMAN	heat shock transcription factor 1	326						cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|large_intestine(1)|lung(3)|prostate(3)|skin(1)|urinary_tract(2)	11	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			CCCTCTTGTCCCCGACCGCCC	0.711000													12	57					0	0	0.003163	0	0
DENND1A	57706	broad.mit.edu	37	9	126144642	126144642	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:126144642G>A	ENST00000373624.2	-	22	2300	c.2099C>T	c.(2098-2100)cCc>cTc	p.P700L	DENND1A_ENST00000542603.1_Missense_Mutation_p.P485L|DENND1A_ENST00000394219.3_Missense_Mutation_p.P711L|DENND1A_ENST00000473039.1_5'UTR	NM_020946.1	NP_065997.1	Q8TEH3	DEN1A_HUMAN	DENN/MADD domain containing 1A	700	Pro-rich.					cell junction|clathrin coated vesicle membrane|presynaptic membrane	guanyl-nucleotide exchange factor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|liver(2)|lung(18)|ovary(2)|prostate(1)|skin(1)|stomach(1)	43						TTGGGGCCGGGGGATGGTGAT	0.692000													12	8					0	0	0.001368	0	0
KMT2B	9757	broad.mit.edu	37	19	36214692	36214692	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:36214692C>T	ENST00000222270.7	+	8	3118	c.3118C>T	c.(3118-3120)Cct>Tct	p.P1040S	KMT2B_ENST00000607650.1_RNA|WBP7_ENST00000420124.1_Missense_Mutation_p.P1040S	NM_014727.1	NP_055542.1																					TGAGGCCTCCCCTGGTCCTCC	0.687000													3	10					0	0	0.004672	0	0
FAT4	79633	broad.mit.edu	37	4	126371308	126371308	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:126371308C>T	ENST00000394329.3	+	9	9150	c.9137C>T	c.(9136-9138)tCc>tTc	p.S3046F	FAT4_ENST00000335110.5_Missense_Mutation_p.S1344F	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3046	Cadherin 29.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						GTAGCATCCTCCCTGATTTCT	0.383000													11	17					0	0	0.000978	0	0
ADCY6	112	broad.mit.edu	37	12	49162479	49162479	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:49162479C>T	ENST00000307885.4	-	21	4096	c.3402G>A	c.(3400-3402)caG>caA	p.Q1134Q	ADCY6_ENST00000550422.1_Silent_p.Q1081Q|ADCY6_ENST00000357869.3_Silent_p.Q1081Q	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	1134					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						CAGCTAGAACCTGGTACAGGT	0.622000													21	44					0	0	0.002299	0	0
SPAG1	6674	broad.mit.edu	37	8	101243404	101243404	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:101243404C>G	ENST00000388798.2	+	15	2067	c.1876C>G	c.(1876-1878)Ctt>Gtt	p.L626V	SPAG1_ENST00000523302.1_3'UTR|SPAG1_ENST00000251809.3_Missense_Mutation_p.L626V	NM_003114.4	NP_003105.2	Q07617	SPAG1_HUMAN	sperm associated antigen 1	626					single fertilization	cytoplasm	GTP binding|hydrolase activity			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(10)|ovary(2)|pancreas(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		ATTTAAAGCCCTTAAGGAAGA	0.318000													32	180					0	0	0.002096	0	0
ARMC2	84071	broad.mit.edu	37	6	109274522	109274522	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:109274522C>T	ENST00000392644.4	+	13	2051	c.1883C>T	c.(1882-1884)cCg>cTg	p.P628L	ARMC2_ENST00000368972.3_Missense_Mutation_p.P463L	NM_032131.4	NP_115507.4	Q8NEN0	ARMC2_HUMAN	armadillo repeat containing 2	628							binding			endometrium(3)|large_intestine(8)|lung(10)|ovary(1)|prostate(1)|skin(1)	24		all_cancers(87;1.14e-07)|Acute lymphoblastic leukemia(125;2.3e-10)|all_hematologic(75;3.3e-08)|all_epithelial(87;0.000111)|Colorectal(196;0.03)|all_lung(197;0.11)		Epithelial(106;0.000197)|BRCA - Breast invasive adenocarcinoma(108;0.000236)|all cancers(137;0.000279)|OV - Ovarian serous cystadenocarcinoma(136;0.00434)		GCCGCCAACCCGGGGATAGTG	0.652000													9	14					0	0	0.004482	0	0
TTC21A	199223	broad.mit.edu	37	3	39152380	39152380	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:39152380G>A	ENST00000301819.6	+	4	484	c.307G>A	c.(307-309)Gaa>Aaa	p.E103K	TTC21A_ENST00000440121.1_Missense_Mutation_p.E103K|TTC21A_ENST00000431162.2_Missense_Mutation_p.E103K	NM_145755.2	NP_665698.2	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A	103							binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(9)|lung(23)|ovary(1)|prostate(1)|skin(3)	50				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CAGCCTGAAGGAAATACGCAA	0.507000													17	35					0	0	0.006122	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3682099	3682099	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:3682099G>A	ENST00000344754.4	-	6	1417	c.1418C>T	c.(1417-1419)tCc>tTc	p.S473F	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.S473F	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	473	Ig-like C2-type 4.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CAGGCGCAGGGAGTTGGGACC	0.597000													17	63					0	0	0.007413	0	0
TNRC18	84629	broad.mit.edu	37	7	5391481	5391481	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:5391481G>A	ENST00000399537.4	-	17	5787	c.5439C>T	c.(5437-5439)ttC>ttT	p.F1813F	TNRC18_ENST00000430969.1_Silent_p.F1813F			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	1813							DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		AAGAGTCGCTGAAGGAGGAAC	0.597000													7	71					0	0	0.004482	0	0
HGFAC	3083	broad.mit.edu	37	4	3446151	3446151	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:3446151G>A	ENST00000382774.3	+	6	827	c.712G>A	c.(712-714)Gaa>Aaa	p.E238K	HGFAC_ENST00000511533.1_Missense_Mutation_p.E238K	NM_001528.2	NP_001519.1	Q04756	HGFA_HUMAN	HGF activator	238	Fibronectin type-I.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|large_intestine(2)|lung(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	22				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		GACCTGGTGCGAAGGCACCCG	0.697000													13	16					0	0	0.003163	0	0
PRB3	5544	broad.mit.edu	37	12	11420678	11420678	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:11420678C>T	ENST00000381842.3	-	0	542				PRB3_ENST00000538488.1_RNA|PRB3_ENST00000440870.3_RNA|PRB3_ENST00000279573.6_RNA	NM_006249.4	NP_006240.4	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3							extracellular region	Gram-negative bacterial cell surface binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(5)	25			OV - Ovarian serous cystadenocarcinoma(49;0.201)			TGGTTTCCTCCTTGTGGGGGT	0.652000													44	74					0	0	0.003610	0	0
CREBBP	1387	broad.mit.edu	37	16	3777962	3777962	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:3777962G>A	ENST00000262367.5	-	31	7895	c.7086C>T	c.(7084-7086)agC>agT	p.S2362S	CREBBP_ENST00000382070.3_Silent_p.S2324S	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	2362					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GTGGTGACGGGCTGGAATGTG	0.652000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						26	42					0	0	0.002445	0	0
BCL2L14	79370	broad.mit.edu	37	12	12247624	12247624	+	Silent	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:12247624C>A	ENST00000586576.1	+	7	952	c.804C>A	c.(802-804)ggC>ggA	p.G268G	BCL2L14_ENST00000396367.1_Silent_p.G235G|BCL2L14_ENST00000308721.5_Silent_p.G235G|BCL2L14_ENST00000396369.1_Intron|BCL2L14_ENST00000266434.4_3'UTR|BCL2L14_ENST00000589718.1_Silent_p.G235G			Q9BZR8	B2L14_HUMAN	BCL2-like 14 (apoptosis facilitator)	235					apoptosis|regulation of apoptosis	cytosol|endomembrane system|intracellular organelle|membrane	protein binding			large_intestine(1)|lung(2)|skin(3)	6		Prostate(47;0.0872)		BRCA - Breast invasive adenocarcinoma(232;0.154)		CTTTGATGGGCCACTTCCAGG	0.493000													49	61					2.31418e-15	3.94896e-15	0.003610	1	0
MROH7	374977	broad.mit.edu	37	1	55136554	55136554	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:55136554C>T	ENST00000414150.2	+	7	1829	c.1551C>T	c.(1549-1551)tcC>tcT	p.S517S	MROH7_ENST00000421030.2_Silent_p.S517S|MROH7_ENST00000454855.2_Silent_p.S35S|MROH7_ENST00000545244.1_Silent_p.S85S|MROH7_ENST00000395690.2_Silent_p.S517S|MROH7_ENST00000409996.1_Silent_p.S85S|MROH7_ENST00000339553.5_Silent_p.S517S					maestro heat-like repeat family member 7																		CCCTGCCCTCCGTGCAGGCGA	0.652000													8	6					0	0	0.000673	0	0
CD40	958	broad.mit.edu	37	20	44750951	44750951	+	Silent	SNP	C	C	T	rs11478618		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:44750951C>T	ENST00000372285.3	+	3	282	c.210C>T	c.(208-210)acC>acT	p.T70T	CD40_ENST00000489304.1_3'UTR|CD40_ENST00000372276.3_Silent_p.T70T	NM_001250.4	NP_001241.1	P25942	TNR5_HUMAN	CD40 molecule, TNF receptor superfamily member 5	70					B cell proliferation|cellular response to mechanical stimulus|inflammatory response|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein complex assembly	CD40 receptor complex|extracellular region	enzyme binding|receptor activity			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	10		Myeloproliferative disorder(115;0.0122)			Simvastatin(DB00641)	TCCTAGACACCTGGAACAGAG	0.527000									Immune Deficiency with Hyper-IgM				19	55					0	0	0.001216	0	0
MYADM	91663	broad.mit.edu	37	19	54377065	54377065	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54377065C>T	ENST00000391769.2	+	3	562	c.282C>T	c.(280-282)ttC>ttT	p.F94F	MYADM_ENST00000391771.1_Silent_p.F94F|MYADM_ENST00000336967.3_Silent_p.F94F|MYADM_ENST00000391770.4_Silent_p.F94F|MYADM_ENST00000391768.2_Silent_p.F94F	NM_001020821.1	NP_001018657.1	Q96S97	MYADM_HUMAN	myeloid-associated differentiation marker	94	MARVEL 1.			Missing (in Ref. 4; BAC04265).		integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	12	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.0488)		AGGCCCGCTTCCCCCTGTCTT	0.617000													30	58					0	0	0.001512	0	0
HIST1H1D	3007	broad.mit.edu	37	6	26234973	26234973	+	Silent	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:26234973A>T	ENST00000244534.5	-	1	243	c.189T>A	c.(187-189)ctT>ctA	p.L63L		NM_005320.2	NP_005311.1	P16402	H13_HUMAN	histone cluster 1, H1d	63	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				GCGCTTTCTTAAGCGCGGCCA	0.547000													50	245					0	0	0.003610	0	0
CYP2A6	1548	broad.mit.edu	37	19	41350595	41350595	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:41350595T>G	ENST00000301141.5	-	8	1264	c.1244A>C	c.(1243-1245)cAc>cCc	p.H415P	CTC-490E21.12_ENST00000601627.1_Intron	NM_000762.5	NP_000753.3	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A, polypeptide 6	415					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(9)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(2)	37			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	ATTCAGGAAGTGCTGGGGATT	0.547000													32	42					0	0	0.002096	0	0
TCEB3	6924	broad.mit.edu	37	1	24080647	24080647	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:24080647C>T	ENST00000418390.2	+	6	1944	c.1673C>T	c.(1672-1674)tCc>tTc	p.S558F		NM_003198.2	NP_003189.2	Q14241	ELOA1_HUMAN	transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)	558	Activation domain (By similarity).				positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		AGAATGAATTCCAAGATGCAG	0.448000													24	60					0	0	0.003954	0	0
TRANK1	9881	broad.mit.edu	37	3	36899148	36899148	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:36899148G>A	ENST00000429976.2	-	12	2180	c.1933C>T	c.(1933-1935)Cca>Tca	p.P645S	TRANK1_ENST00000428977.2_Missense_Mutation_p.P95S|TRANK1_ENST00000301807.6_Missense_Mutation_p.P95S			O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	645					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						GCACCACATGGCACTGACTTG	0.602000													27	79					0	0	0.007291	0	0
LILRB1	10859	broad.mit.edu	37	19	55143505	55143505	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55143505G>A	ENST00000396331.1	+	6	835	c.478G>A	c.(478-480)Gga>Aga	p.G160R	LILRB1_ENST00000418536.2_Missense_Mutation_p.G160R|LILRB1_ENST00000396317.1_Missense_Mutation_p.G160R|LILRB1_ENST00000396321.2_Missense_Mutation_p.G160R|LILRB1_ENST00000434867.2_Missense_Mutation_p.G160R|LILRB1_ENST00000324602.7_Missense_Mutation_p.G160R|LILRB1_ENST00000427581.2_Missense_Mutation_p.G196R|LILRB1_ENST00000396332.4_Missense_Mutation_p.G160R|LILRB1_ENST00000448689.1_Missense_Mutation_p.G160R|LILRB1_ENST00000396315.1_Missense_Mutation_p.G160R|LILRB1_ENST00000396327.3_Missense_Mutation_p.G160R	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	160	Ig-like C2-type 2.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		GTGTAAGGAAGGAGAAGATGA	0.607000										HNSCC(37;0.09)			27	46					0	0	0.005443	0	0
FLRT2	23768	broad.mit.edu	37	14	86089130	86089130	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:86089130G>A	ENST00000330753.4	+	2	2039	c.1272G>A	c.(1270-1272)cgG>cgA	p.R424R	FLRT2_ENST00000554746.1_Silent_p.R424R	NM_013231.4	NP_037363.1	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	424	Fibronectin type-III.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			NS(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(21)|lung(27)|ovary(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	73				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TTTCTGAACGGATCCAGCTCT	0.483000													12	22					0	0	0.001368	0	0
FLVCR2	55640	broad.mit.edu	37	14	76107327	76107327	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:76107327G>A	ENST00000238667.4	+	7	1621	c.1265G>A	c.(1264-1266)gGa>gAa	p.G422E	FLVCR2_ENST00000539311.1_Missense_Mutation_p.G217E|FLVCR2_ENST00000556856.1_Intron|FLVCR2_ENST00000553587.1_Intron|FLVCR2_ENST00000555027.1_Missense_Mutation_p.G137E|FLVCR2_ENST00000556241.1_Intron	NM_017791.2	NP_060261.2	Q9UPI3	FLVC2_HUMAN	feline leukemia virus subgroup C cellular receptor family, member 2	422					transmembrane transport	integral to membrane|plasma membrane	heme binding|heme transporter activity			endometrium(3)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	15				BRCA - Breast invasive adenocarcinoma(234;0.029)		CTCCCACTGGGATTTGAGTTT	0.502000													30	40					0	0	0.003755	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37436309	37436309	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:37436309G>A	ENST00000374660.1	+	9	1398	c.1299G>A	c.(1297-1299)gaG>gaA	p.E433E	ANKRD30A_ENST00000602533.1_Silent_p.E433E|ANKRD30A_ENST00000361713.1_Silent_p.E433E			Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	489						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(8)|endometrium(14)|kidney(21)|large_intestine(13)|lung(70)|ovary(8)|pancreas(1)|prostate(3)|skin(15)|stomach(1)|urinary_tract(3)	158						GTCTCTTTGAGAGTTCTGCAA	0.254000													11	27					0	0	0.002450	0	0
ALOX5	240	broad.mit.edu	37	10	45924071	45924071	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:45924071G>A	ENST00000374391.2	+	7	893	c.840G>A	c.(838-840)ggG>ggA	p.G280G	ALOX5_ENST00000542434.1_Silent_p.G280G	NM_000698.3|NM_001256153.1	NP_000689.1|NP_001243082.1	P09917	LOX5_HUMAN	arachidonate 5-lipoxygenase	280	Lipoxygenase.				hormone biosynthetic process|leukotriene biosynthetic process|prostanoid metabolic process	cytosol|nuclear envelope lumen|nuclear matrix|nuclear membrane	arachidonate 5-lipoxygenase activity|iron ion binding|lipoxygenase activity|protein binding			breast(1)|cervix(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(14)|ovary(2)|pancreas(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	37		Lung SC(717;0.0257)			Diethylcarbamazine(DB00711)|Hydrocortisone(DB00741)|Leflunomide(DB01097)|Masoprocol(DB00179)|Meclofenamic acid(DB00939)|Minocycline(DB01017)|Montelukast(DB00471)|Quinacrine(DB01103)|Vitamin E(DB00163)|Zileuton(DB00744)	TGCAGCAAGGGAACATTTTCA	0.552000													10	17					0	0	0.002450	0	0
KIAA0556	23247	broad.mit.edu	37	16	27720122	27720122	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:27720122A>C	ENST00000261588.4	+	13	1505	c.1486A>C	c.(1486-1488)Aca>Cca	p.T496P	CTD-2049O4.1_ENST00000568831.1_RNA|KIAA0556_ENST00000567894.1_3'UTR|CTD-2049O4.1_ENST00000563052.1_RNA|CTD-2049O4.1_ENST00000564893.1_RNA	NM_015202.2	NP_056017.2	O60303	K0556_HUMAN	KIAA0556	496										breast(4)|endometrium(7)|kidney(8)|large_intestine(17)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	76						GGTGGGTCTCACAGAAGTCGA	0.537000													15	56					0	0	0.004990	0	0
TGFBI	7045	broad.mit.edu	37	5	135389719	135389719	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:135389719C>T	ENST00000442011.2	+	9	1375	c.1214C>T	c.(1213-1215)tCt>tTt	p.S405F	TGFBI_ENST00000305126.8_Missense_Mutation_p.S405F	NM_000358.2	NP_000349.1	Q15582	BGH3_HUMAN	transforming growth factor, beta-induced, 68kDa	405	FAS1 3.				angiogenesis|cell adhesion|cell proliferation|negative regulation of cell adhesion|response to stimulus|visual perception	extracellular space|proteinaceous extracellular matrix	integrin binding			breast(6)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AATCATCTCTCTGGAAGTGAG	0.517000													73	88					0	0	0.003610	0	0
CLU	1191	broad.mit.edu	37	8	27455997	27455997	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:27455997C>T	ENST00000316403.10	-	8	1725	c.1320G>A	c.(1318-1320)caG>caA	p.Q440Q	CLU_ENST00000546343.1_Silent_p.Q451Q|CLU_ENST00000405140.3_Silent_p.Q440Q|CLU_ENST00000523500.1_Silent_p.Q440Q|CLU_ENST00000560366.1_Silent_p.Q492Q			P10909	CLUS_HUMAN	clusterin	440					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)	21		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		TGCGGTATTCCTGCAGCGCTT	0.537000													37	73					0	0	0.004878	0	0
CST9L	128821	broad.mit.edu	37	20	23549030	23549030	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:23549030C>T	ENST00000376979.3	-	1	356	c.58G>A	c.(58-60)Ggc>Agc	p.G20S		NM_080610.2	NP_542177.1	Q9H4G1	CST9L_HUMAN	cystatin 9-like	20						extracellular region	cysteine-type endopeptidase inhibitor activity	p.G20C(1)		breast(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	8	Colorectal(13;0.0431)|Lung NSC(19;0.235)					ATCTGGGAGCCTAAGAGAAGC	0.582000													11	30					0	0	0.001855	0	0
EDEM3	80267	broad.mit.edu	37	1	184702001	184702001	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:184702001G>A	ENST00000318130.8	-	6	848	c.582C>T	c.(580-582)ttC>ttT	p.F194F	EDEM3_ENST00000367512.3_Silent_p.F151F	NM_025191.3	NP_079467.3	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like 3	194					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	30						TGGTAGTGTTGAAAGCCGGTA	0.353000													20	62					0	0	0.002299	0	0
PLEKHS1	79949	broad.mit.edu	37	10	115526193	115526193	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:115526193G>A	ENST00000361048.1	+	3	379	c.52G>A	c.(52-54)Gaa>Aaa	p.E18K	PLEKHS1_ENST00000369310.3_Missense_Mutation_p.E12K|PLEKHS1_ENST00000369312.4_5'UTR	NM_024889.4	NP_079165.3			pleckstrin homology domain containing, family S member 1																		ATTTTCTTATGAAAATGAAGT	0.348000													16	40					0	0	0.004007	0	0
PNKD	25953	broad.mit.edu	37	2	219204778	219204778	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:219204778C>T	ENST00000273077.4	+	4	430	c.379C>T	c.(379-381)Ctc>Ttc	p.L127F	PNKD_ENST00000436005.2_Missense_Mutation_p.L67F|AC021016.8_ENST00000411433.1_RNA|PNKD_ENST00000258362.3_Missense_Mutation_p.L103F	NM_015488.4	NP_056303.3	Q8N490	PNKD_HUMAN	paroxysmal nonkinesigenic dyskinesia	127						membrane|mitochondrion|nucleus	hydroxyacylglutathione hydrolase activity|zinc ion binding			NS(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(2)	10		Renal(207;0.0474)		Epithelial(149;7.33e-07)|all cancers(144;0.000133)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CATCCCTGTCCTCTCGGACAA	0.642000													23	20					0	0	0.002780	0	0
ZFHX4	79776	broad.mit.edu	37	8	77764947	77764947	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:77764947G>A	ENST00000521891.2	+	10	6238	c.5790G>A	c.(5788-5790)aaG>aaA	p.K1930K	ZFHX4_ENST00000050961.6_Silent_p.K1885K|ZFHX4_ENST00000455469.2_Silent_p.K1885K|ZFHX4_ENST00000518282.1_Silent_p.K1904K	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	1885						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACAGGCAGAAGGTACAGAAGA	0.413000										HNSCC(33;0.089)			17	78					0	0	0.007413	0	0
PANK3	79646	broad.mit.edu	37	5	167995999	167995999	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:167995999G>A	ENST00000239231.6	-	2	349	c.33C>T	c.(31-33)ttC>ttT	p.F11F		NM_024594.3	NP_078870.1	Q9H999	PANK3_HUMAN	pantothenate kinase 3	11					coenzyme A biosynthetic process	cytoplasm|nucleus	ATP binding|pantothenate kinase activity			NS(1)|cervix(2)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|pancreas(1)|skin(1)|urinary_tract(1)	16	Renal(175;0.000159)|Lung NSC(126;0.0441)|all_lung(126;0.0909)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0989)|OV - Ovarian serous cystadenocarcinoma(192;0.147)|Epithelial(171;0.188)		CAAACCATGGGAAAGCTATGG	0.328000													10	51					0	0	0.006214	0	0
PCDHA13	56136	broad.mit.edu	37	5	140263218	140263218	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140263218C>T	ENST00000289272.2	+	1	1365	c.1365C>T	c.(1363-1365)ttC>ttT	p.F455F	PCDHA5_ENST00000529859.1_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA13_ENST00000409494.1_Silent_p.F455F|PCDHA10_ENST00000307360.5_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA10_ENST00000506939.2_Intron|PCDHA11_ENST00000398640.2_Intron|PCDHA8_ENST00000531613.1_Intron|PCDHA1_ENST00000394633.3_Intron|PCDHA12_ENST00000398631.2_Intron|PCDHA7_ENST00000525929.1_Intron	NM_018904.2|NM_031865.1	NP_061727.1|NP_114071.1														NS(1)|biliary_tract(2)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(7)|kidney(2)|large_intestine(18)|liver(3)|lung(23)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(2)	95			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGCCGGCGTTCGCGCAGCCCG	0.682000													19	91					0	0	0.001216	0	0
PHLDB2	90102	broad.mit.edu	37	3	111632513	111632513	+	Silent	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:111632513T>G	ENST00000431670.2	+	3	2094	c.1683T>G	c.(1681-1683)gcT>gcG	p.A561A	PHLDB2_ENST00000412622.1_Silent_p.A561A|PHLDB2_ENST00000481953.1_Silent_p.A561A|PHLDB2_ENST00000477695.1_Silent_p.A561A|PHLDB2_ENST00000393925.3_Silent_p.A561A|PHLDB2_ENST00000495180.1_Silent_p.A147A|PHLDB2_ENST00000393923.3_Silent_p.A588A	NM_001134438.1	NP_001127910.1	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B, member 2	561						cytoplasm|intermediate filament cytoskeleton|plasma membrane				breast(2)|central_nervous_system(1)|endometrium(7)|large_intestine(8)|lung(23)|ovary(6)|skin(7)|stomach(1)	55						TTCCGAAAGCTTCCAGCGAGT	0.507000													57	167					0	0	0.003610	0	0
NLRP9	338321	broad.mit.edu	37	19	56226485	56226485	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:56226485C>T	ENST00000332836.2	-	6	2464	c.2437G>A	c.(2437-2439)Gat>Aat	p.D813N		NM_176820.2	NP_789790.2	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	813						cytoplasm	ATP binding			NS(2)|breast(5)|cervix(1)|endometrium(7)|kidney(8)|large_intestine(15)|lung(21)|ovary(2)|prostate(3)|skin(7)|urinary_tract(3)	74		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		ACTCCATTATCTTCCAGGGCA	0.547000													30	64					0	0	0.007291	0	0
VWCE	220001	broad.mit.edu	37	11	61042021	61042021	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:61042021C>T	ENST00000335613.5	-	12	1917	c.1531G>A	c.(1531-1533)Ggg>Agg	p.G511R		NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	511	VWFC 3.					extracellular region	calcium ion binding	p.G511W(1)		biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						AACACAGCCCCGTCTGCGTAC	0.572000													14	13					0	0	0.004990	0	0
MAD1L1	8379	broad.mit.edu	37	7	2108866	2108866	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2108866G>A	ENST00000406869.1	-	12	1738	c.1181C>T	c.(1180-1182)gCc>gTc	p.A394V	MAD1L1_ENST00000399654.2_Missense_Mutation_p.A394V|MAD1L1_ENST00000265854.7_Missense_Mutation_p.A394V|MAD1L1_ENST00000402746.1_Missense_Mutation_p.A302V			Q9Y6D9	MD1L1_HUMAN	MAD1 mitotic arrest deficient-like 1 (yeast)	394	Necessary for interaction with NEK2.				cell division|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase|mitotic prometaphase|mitotic telophase	actin cytoskeleton|centrosome|condensed chromosome kinetochore|cytosol|mitochondrion|nucleus|spindle	protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(20)|ovary(1)|prostate(5)	36		Ovarian(82;0.0272)		UCEC - Uterine corpus endometrioid carcinoma (27;0.134)|OV - Ovarian serous cystadenocarcinoma(56;3.63e-14)		GAGCCTCCGGGCCAGCGCCTC	0.642000													23	157					0	0	0.001786	0	0
CDK11B	984	broad.mit.edu	37	1	1575742	1575742	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:1575742G>A	ENST00000407249.3	-	12	1155	c.1156C>T	c.(1156-1158)Ccg>Tcg	p.P386S	CDK11B_ENST00000341832.6_Missense_Mutation_p.P339S|CDK11B_ENST00000340677.5_Missense_Mutation_p.P373S|CDK11B_ENST00000317673.7_Missense_Mutation_p.P384S			P21127	CD11B_HUMAN	cyclin-dependent kinase 11B	396	Glu-rich.				apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			endometrium(2)|large_intestine(3)|lung(4)|skin(1)|stomach(2)	12						CTGCTCTGCGGCGTTCCCTCA	0.597000													10	34					0	0	0.000673	0	0
ACTL7A	10881	broad.mit.edu	37	9	111625832	111625832	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:111625832G>A	ENST00000333999.3	+	1	1230	c.1230G>A	c.(1228-1230)caG>caA	p.Q410Q		NM_006687.2	NP_006678.1	Q9Y615	ACL7A_HUMAN	actin-like 7A	410						cytoplasm|cytoskeleton|protein complex	structural constituent of cytoskeleton			breast(1)|endometrium(2)|large_intestine(4)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CCTCACTTCAGGGTTTCCAAC	0.562000													50	6					0	0	0.003610	0	0
ZNF543	125919	broad.mit.edu	37	19	57839423	57839423	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57839423C>T	ENST00000321545.4	+	4	938	c.593C>T	c.(592-594)tCc>tTc	p.S198F		NM_213598.3	NP_998763.2	Q08ER8	ZN543_HUMAN	zinc finger protein 543	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|kidney(2)|large_intestine(8)|lung(11)|pancreas(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)	28		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		GAGAAAAATTCCTATAAATGT	0.403000													23	67					0	0	0.002299	0	0
COL11A1	1301	broad.mit.edu	37	1	103347311	103347311	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:103347311G>A	ENST00000358392.2	-	65	5335	c.5018C>T	c.(5017-5019)tCa>tTa	p.S1673L	COL11A1_ENST00000370096.3_Missense_Mutation_p.S1661L|COL11A1_ENST00000353414.4_Missense_Mutation_p.S1622L|COL11A1_ENST00000512756.1_Missense_Mutation_p.S1545L	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1661	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGGCCATGATGAAATTCTTAC	0.318000													4	14					0	0	0.001168	0	0
FILIP1	27145	broad.mit.edu	37	6	76022585	76022585	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:76022585C>T	ENST00000393004.2	-	5	3184	c.2963G>A	c.(2962-2964)aGa>aAa	p.R988K	FILIP1_ENST00000498523.1_5'UTR|FILIP1_ENST00000237172.7_Missense_Mutation_p.R988K|FILIP1_ENST00000370020.1_Missense_Mutation_p.R889K			Q7Z7B0	FLIP1_HUMAN	filamin A interacting protein 1	988										breast(3)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|liver(1)|lung(28)|ovary(1)|pancreas(1)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)	80						AGTCTTCTCTCTGGAAAATGT	0.463000													26	38					0	0	0.004656	0	0
GIGYF2	26058	broad.mit.edu	37	2	233721532	233721532	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:233721532C>T	ENST00000373566.3	+	30	4125	c.3928C>T	c.(3928-3930)Ctc>Ttc	p.L1310F	GIGYF2_ENST00000409196.3_Missense_Mutation_p.L1282F|GIGYF2_ENST00000409451.3_Missense_Mutation_p.L1309F|GIGYF2_ENST00000373563.4_Missense_Mutation_p.L1288F|GIGYF2_ENST00000409547.1_Missense_Mutation_p.L1288F|GIGYF2_ENST00000409480.1_Missense_Mutation_p.L1310F			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	1288					cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		ATCGGAGCGACTCAACATGGG	0.527000													21	34					0	0	0.003330	0	0
ENTPD1	953	broad.mit.edu	37	10	97602187	97602187	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:97602187C>T	ENST00000371207.3	+	4	448	c.385C>T	c.(385-387)Cca>Tca	p.P129S	ENTPD1_ENST00000453258.2_Missense_Mutation_p.P124S|RP11-429G19.3_ENST00000433113.1_RNA|ENTPD1-AS1_ENST00000416301.1_RNA|ENTPD1_ENST00000490659.1_3'UTR|ENTPD1_ENST00000539125.1_Intron|ENTPD1_ENST00000543964.1_Missense_Mutation_p.P9S|ENTPD1_ENST00000371203.5_Intron|ENTPD1_ENST00000371205.4_Missense_Mutation_p.P117S	NM_001164178.1	NP_001157650.1	P49961	ENTP1_HUMAN	ectonucleoside triphosphate diphosphohydrolase 1	117					cell adhesion	integral to plasma membrane	ATP binding			cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|prostate(1)|skin(1)	16		Colorectal(252;0.0821)		Epithelial(162;1.31e-07)|all cancers(201;5.33e-06)		GGAAGTGATTCCAAGGTCCCA	0.473000													29	48					0	0	0.001786	0	0
CRB1	23418	broad.mit.edu	37	1	197403878	197403878	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:197403878T>C	ENST00000367397.1	+	5	1886	c.1028T>C	c.(1027-1029)tTa>tCa	p.L343S	CRB1_ENST00000544212.1_Missense_Mutation_p.L443S|CRB1_ENST00000535699.1_Missense_Mutation_p.L938S|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000367399.2_Missense_Mutation_p.L850S|CRB1_ENST00000367400.3_Missense_Mutation_p.L962S			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	962	EGF-like 9.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						GGTCAAATATTATTCAGAAGC	0.308000													38	83					0	0	0.001951	0	0
TREML1	340205	broad.mit.edu	37	6	41121741	41121741	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:41121741T>G	ENST00000373127.4	-	2	179	c.131A>C	c.(130-132)gAt>gCt	p.D44A	TREML1_ENST00000437044.2_Intron|TREML1_ENST00000426005.2_Missense_Mutation_p.D44A	NM_001271807.1	NP_001258736.1	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid cells-like 1	44	Ig-like V-type.				calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)	13	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGCTTTGACATCCTGGAGCCT	0.632000													11	71					0	0	0.000673	0	0
FFAR4	338557	broad.mit.edu	37	10	95347351	95347351	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:95347351G>A	ENST00000371483.4	+	4	1175	c.1119G>A	c.(1117-1119)tcG>tcA	p.S373S	FFAR4_ENST00000371481.4_Silent_p.S357S|FFAR4_ENST00000604414.1_Intron	NM_181745.3	NP_859529.2			free fatty acid receptor 4																		ATGACTTGTCGATTATTTCTG	0.418000													33	24					0	0	0.003755	0	0
MKL2	57496	broad.mit.edu	37	16	14345761	14345761	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:14345761C>T	ENST00000571589.1	+	14	2618	c.2446C>T	c.(2446-2448)Cag>Tag	p.Q816*	MKL2_ENST00000318282.5_Nonsense_Mutation_p.Q766*|MKL2_ENST00000341243.5_Nonsense_Mutation_p.Q805*|MKL2_ENST00000574045.1_Nonsense_Mutation_p.Q766*	NM_014048.3	NP_054767.3	Q9ULH7	MKL2_HUMAN	MKL/myocardin-like 2	805					cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(6)|large_intestine(6)|liver(2)|lung(7)|ovary(4)|pancreas(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	42						TCTTCCATATCAGAGACATCC	0.403000													28	41					0	0	0.002096	0	0
SH3GL2	6456	broad.mit.edu	37	9	17786423	17786423	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:17786423C>T	ENST00000380607.4	+	4	352	c.232C>T	c.(232-234)Cgt>Tgt	p.R78C	SH3GL2_ENST00000537391.1_Missense_Mutation_p.R31C	NM_003026.2	NP_003017.1	Q99962	SH3G2_HUMAN	SH3-domain GRB2-like 2	78	BAR.|Binds and tubulates liposomes (By similarity).|Required for dimerization upon membrane association (By similarity).				axon guidance|central nervous system development|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport	cytosol|Golgi membrane|plasma membrane	identical protein binding|lipid binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(11)|skin(3)|upper_aerodigestive_tract(1)	26				GBM - Glioblastoma multiforme(50;2.71e-10)|Lung(42;0.203)		GTCAAAAATCCGTGGCCAGGA	0.507000													33	40					0	0	0.004289	0	0
INSR	3643	broad.mit.edu	37	19	7120643	7120643	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:7120643G>A	ENST00000341500.5	-	19	3650	c.3611C>T	c.(3610-3612)tCt>tTt	p.S1204F	INSR_ENST00000302850.5_Missense_Mutation_p.S1216F	NM_001079817.1	NP_001073285.1	P06213	INSR_HUMAN	insulin receptor	1216	Protein kinase.				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			breast(1)|central_nervous_system(4)|endometrium(6)|kidney(2)|large_intestine(13)|lung(25)|ovary(4)|prostate(4)|skin(3)|stomach(2)|urinary_tract(2)	66					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CATGTCAGAAGAAGTGGTGAA	0.562000													64	102					0	0	0.003610	0	0
DUSP26	78986	broad.mit.edu	37	8	33454829	33454829	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:33454829G>A	ENST00000256261.4	-	2	722	c.205C>T	c.(205-207)Ctc>Ttc	p.L69F	DUSP26_ENST00000523956.1_Missense_Mutation_p.L69F	NM_024025.1	NP_076930.1	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26 (putative)	69	Tyrosine-protein phosphatase.					Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(1)|kidney(1)|large_intestine(4)|lung(7)|skin(1)	15				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		CCGAGATAGAGGCCTGGCCAG	0.552000													9	9					0	0	0.006214	0	0
PRDM14	63978	broad.mit.edu	37	8	70980503	70980503	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:70980503C>T	ENST00000276594.2	-	4	1075	c.874G>A	c.(874-876)Gaa>Aaa	p.E292K		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	292	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			GTCTTCACTTCACTGGCATTG	0.493000													19	120					0	0	0.001216	0	0
JAKMIP2	9832	broad.mit.edu	37	5	147010991	147010991	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:147010991C>T	ENST00000265272.5	-	14	2327	c.1860G>A	c.(1858-1860)atG>atA	p.M620I	JAKMIP2_ENST00000333010.6_Missense_Mutation_p.M578I|JAKMIP2_ENST00000507386.1_Missense_Mutation_p.M599I	NM_014790.3	NP_055605.2	Q96AA8	JKIP2_HUMAN	janus kinase and microtubule interacting protein 2	620						Golgi apparatus				NS(1)|autonomic_ganglia(1)|breast(3)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(22)|lung(18)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)	64			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CACCTTCTTTCATACAGTAGA	0.383000													23	29					0	0	0.005443	0	0
TMPRSS11B	132724	broad.mit.edu	37	4	69101868	69101868	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:69101868C>T	ENST00000332644.5	-	3	402		c.e3+1			NM_182502.3	NP_872308.2	Q86T26	TM11B_HUMAN	transmembrane protease, serine 11B						proteolysis	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|skin(1)	27						CTCTGATTTACCTTAGTCTCA	0.284000													7	12					0	0	0.001984	0	0
TOP3B	8940	broad.mit.edu	37	22	22312879	22312879	+	Nonsense_Mutation	SNP	G	G	A	rs142196057		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:22312879G>A	ENST00000398793.2	-	17	2526	c.2092C>T	c.(2092-2094)Cga>Tga	p.R698*	TOP3B_ENST00000357179.5_Nonsense_Mutation_p.R698*	NM_003935.3	NP_003926.1	O95985	TOP3B_HUMAN	topoisomerase (DNA) III beta	698					DNA topological change	nucleus	ATP binding|DNA topoisomerase type I activity|protein binding			breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(4)|lung(9)|ovary(1)	26	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.145)		TTCATGTCTCGGAAGGGTGGG	0.602000													25	144					0	0	0.004656	0	0
CCNT2	905	broad.mit.edu	37	2	135676478	135676478	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:135676478G>A	ENST00000264157.5	+	1	84	c.54G>A	c.(52-54)ctG>ctA	p.L18L	CCNT2_ENST00000537343.1_5'UTR|CCNT2_ENST00000295238.6_Silent_p.L18L	NM_001241.3|NM_058241.2	NP_001232.1|NP_490595.1	O60583	CCNT2_HUMAN	cyclin T2	18					cell cycle|cell division|interspecies interaction between organisms|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	protein kinase binding			endometrium(2)|kidney(3)|large_intestine(10)|lung(6)|ovary(2)|prostate(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(221;0.107)		GGGAACAGCTGGAGAACACGC	0.647000													5	14					0	0	0.000602	0	0
KMT2E	55904	broad.mit.edu	37	7	104752452	104752452	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:104752452C>T	ENST00000334877.4	+	26	4657	c.4123C>T	c.(4123-4125)Cct>Tct	p.P1375S	SRPK2_ENST00000493638.1_Intron|KMT2E_ENST00000311117.3_Missense_Mutation_p.P1417S|KMT2E_ENST00000334914.7_Missense_Mutation_p.P472S|KMT2E_ENST00000257745.4_Missense_Mutation_p.P1417S					lysine (K)-specific methyltransferase 2E																		GAATCATCCTCCTCAGACACA	0.423000													27	25					0	0	0.005443	0	0
BRSK1	84446	broad.mit.edu	37	19	55816891	55816891	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55816891C>T	ENST00000309383.1	+	16	2104	c.1827C>T	c.(1825-1827)ttC>ttT	p.F609F	BRSK1_ENST00000588584.1_3'UTR|BRSK1_ENST00000590333.1_Silent_p.F625F|BRSK1_ENST00000326848.7_Silent_p.F304F	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	609					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		AACAAATATTCCTCGTGCTAA	0.572000													56	128					0	0	0.003610	0	0
GSX2	170825	broad.mit.edu	37	4	54967870	54967870	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:54967870G>A	ENST00000326902.2	+	2	1010	c.696G>A	c.(694-696)agG>agA	p.R232R	GSX2_ENST00000548609.1_3'UTR|GSX2_ENST00000503800.1_3'UTR|FIP1L1_ENST00000507166.1_Intron	NM_133267.2	NP_573574.1	Q9BZM3	GSX2_HUMAN	GS homeobox 2	232						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(2)|lung(2)	6	all_cancers(7;0.00671)|Lung NSC(11;0.0154)|all_neural(26;0.0209)|Glioma(25;0.08)|all_epithelial(27;0.147)		LUSC - Lung squamous cell carcinoma(32;0.00216)			GACTCCGGAGGATTGAAATCG	0.532000													29	260					0	0	0.001512	0	0
UGT1A4	54657	broad.mit.edu	37	2	234628284	234628284	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:234628284T>C	ENST00000373409.3	+	1	861	c.818T>C	c.(817-819)aTg>aCg	p.M273T	UGT1A6_ENST00000480628.1_Intron|UGT1A6_ENST00000373424.1_Intron|UGT1A9_ENST00000354728.4_Intron|UGT1A8_ENST00000373450.4_Intron|UGT1A6_ENST00000305139.6_Intron|UGT1A6_ENST00000406651.1_Intron|UGT1A5_ENST00000373414.3_Intron|UGT1A7_ENST00000373426.3_Intron|UGT1A10_ENST00000373445.1_Intron|UGT1A10_ENST00000344644.5_Intron	NM_007120.2	NP_009051.1														autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(2)|large_intestine(5)|lung(9)|ovary(1)|skin(2)|urinary_tract(1)	26		Breast(86;0.000765)|all_lung(227;0.00266)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0456)|Lung SC(224;0.128)		Epithelial(121;3.49e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000504)|Lung(119;0.0026)|LUSC - Lung squamous cell carcinoma(224;0.00624)		ATGCCCAACATGGTCTTCATT	0.512000													10	93					0	0	0.001855	0	0
MTHFD1L	25902	broad.mit.edu	37	6	151206843	151206843	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:151206843G>A	ENST00000367321.3	+	6	890	c.616G>A	c.(616-618)Gct>Act	p.A206T	MTHFD1L_ENST00000367307.4_Missense_Mutation_p.A206T	NM_001242767.1|NM_001242768.1|NM_015440.4	NP_001229696.1|NP_001229697.1|NP_056255.2	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like	206	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(12)|lung(8)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)	29		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		TGTTGCCAAAGCTGTAATTGA	0.368000													29	42					0	0	0.006320	0	0
ACTR5	79913	broad.mit.edu	37	20	37400291	37400291	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:37400291C>T	ENST00000243903.4	+	9	1693	c.1656C>T	c.(1654-1656)atC>atT	p.I552I		NM_024855.3	NP_079131.3	Q9H9F9	ARP5_HUMAN	ARP5 actin-related protein 5 homolog (yeast)	552					DNA recombination|double-strand break repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent|UV-damage excision repair	cytoplasm|Ino80 complex	ATP binding|protein binding			kidney(2)|large_intestine(2)|liver(1)|lung(5)|skin(2)	12		Myeloproliferative disorder(115;0.00878)				AAGTTTGGATCACCAGGAAAG	0.527000													11	84					0	0	0.000673	0	0
CNOT6L	246175	broad.mit.edu	37	4	78669520	78669520	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:78669520G>A	ENST00000504123.1	-	6	639	c.509C>T	c.(508-510)cCt>cTt	p.P170L	CNOT6L_ENST00000506166.1_5'UTR|CNOT6L_ENST00000264903.4_Missense_Mutation_p.P170L			Q96LI5	CNO6L_HUMAN	CCR4-NOT transcription complex, subunit 6-like	170					nuclear-transcribed mRNA poly(A) tail shortening	cytosol	exonuclease activity|protein binding			kidney(1)|large_intestine(1)|lung(6)|urinary_tract(1)	9						TGGCCTCGGAGGAAGCTGCTC	0.313000													32	48					0	0	0.005524	0	0
NRM	11270	broad.mit.edu	37	6	30658016	30658016	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:30658016G>A	ENST00000259953.4	-	3	489	c.138C>T	c.(136-138)gcC>gcT	p.A46A	NRM_ENST00000376421.5_Silent_p.A46A|NRM_ENST00000470733.1_5'UTR|NRM_ENST00000376420.5_Silent_p.A46A	NM_001270707.1	NP_001257636.1	Q8IXM6	NRM_HUMAN	nurim (nuclear envelope membrane protein)	46						integral to membrane|nuclear inner membrane				large_intestine(1)|lung(2)	3						ATCCCTGGCGGGCATCTACAG	0.582000													5	43					0	0	0.000602	0	0
PRKACG	5568	broad.mit.edu	37	9	71628130	71628130	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:71628130C>T	ENST00000377276.2	-	1	909	c.879G>A	c.(877-879)aaG>aaA	p.K293K		NM_002732.3	NP_002723.2	P22612	KAPCG_HUMAN	protein kinase, cAMP-dependent, catalytic, gamma	293	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						ACTTGTGGTTCTTGATGTCGC	0.572000													116	11					0	0	0.003610	0	0
HEPHL1	341208	broad.mit.edu	37	11	93797567	93797567	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:93797567G>A	ENST00000315765.9	+	4	707	c.699G>A	c.(697-699)gtG>gtA	p.V233V		NM_001098672.1	NP_001092142.1	Q6MZM0	HPHL1_HUMAN	hephaestin-like 1	233	Plastocyanin-like 2.				copper ion transport	integral to membrane	copper ion binding|oxidoreductase activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(11)|lung(25)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	61		Acute lymphoblastic leukemia(157;2.34e-05)|all_hematologic(158;0.00824)				TTACTCTTGTGGATGAGAATC	0.393000													21	18					0	0	0.001882	0	0
TNN	63923	broad.mit.edu	37	1	175046794	175046794	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:175046794G>A	ENST00000239462.4	+	2	353	c.240G>A	c.(238-240)gaG>gaA	p.E80E		NM_022093.1	NP_071376.1	Q9UQP3	TENN_HUMAN	tenascin N	80					cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				NS(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|liver(1)|lung(81)|ovary(5)|prostate(6)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	156		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		AGGCCAGGGAGGAACAGAACA	0.607000													34	15					0	0	0.006999	0	0
TPRN	286262	broad.mit.edu	37	9	140093724	140093724	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:140093724C>T	ENST00000409012.4	-	1	1526	c.1440G>A	c.(1438-1440)agG>agA	p.R480R	TPRN_ENST00000541945.1_Intron|TPRN_ENST00000321773.2_Silent_p.R419R	NM_001128228.2	NP_001121700.2	Q4KMQ1	TPRN_HUMAN	taperin	480					sensory perception of sound	stereocilium				breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)	8						GGTGCAGAGGCCTGGCAGGGT	0.652000													19	29					0	0	0.001523	0	0
PPARGC1B	133522	broad.mit.edu	37	5	149212591	149212591	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:149212591C>T	ENST00000309241.5	+	5	987	c.955C>T	c.(955-957)Ccc>Tcc	p.P319S	PPARGC1B_ENST00000403750.1_Missense_Mutation_p.P255S|PPARGC1B_ENST00000360453.4_Missense_Mutation_p.P280S|PPARGC1B_ENST00000394320.3_Missense_Mutation_p.P319S	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	319					estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			CTGCAGCAACCCCTCCCAGCA	0.627000													22	42					0	0	0.003330	0	0
DEFB136	613210	broad.mit.edu	37	8	11831451	11831451	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:11831451G>A	ENST00000382209.2	-	2	231	c.232C>T	c.(232-234)Cat>Tat	p.H78Y		NM_001033018.2	NP_001028190.2	Q30KP8	DB136_HUMAN	defensin, beta 136	78					defense response to bacterium	extracellular region				endometrium(2)|large_intestine(1)|lung(4)	7			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.163)		TCCTTTTAATGAACCCATGGA	0.453000													49	165					0	0	0.003610	0	0
TTLL2	83887	broad.mit.edu	37	6	167753716	167753716	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:167753716A>T	ENST00000239587.5	+	3	416	c.328A>T	c.(328-330)Aag>Tag	p.K110*		NM_031949.4	NP_114155.4	Q9BWV7	TTLL2_HUMAN	tubulin tyrosine ligase-like family, member 2	110	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(17)|ovary(1)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	39		Breast(66;7.8e-06)|Ovarian(120;0.024)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		GGGGTGGAATAAGTTTGATAA	0.552000													14	10					0	0	0.001855	0	0
CDH13	1012	broad.mit.edu	37	16	83711929	83711929	+	Silent	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:83711929T>G	ENST00000566620.1	+	10	1691	c.1401T>G	c.(1399-1401)acT>acG	p.T467T	CDH13_ENST00000428848.3_Silent_p.T428T|CDH13_ENST00000268613.10_Silent_p.T514T	NM_001220488.1|NM_001220489.1|NM_001220490.1|NM_001257.4	NP_001207417.1|NP_001207418.1|NP_001207419.1|NP_001248.1	P55290	CAD13_HUMAN	cadherin 13	467	Cadherin 3.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		TCCACATCACTGTCCTGGATG	0.582000													18	54					0	0	0.001216	0	0
ATRIP	84126	broad.mit.edu	37	3	48501578	48501578	+	Silent	SNP	G	G	A	rs139858543	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:48501578G>A	ENST00000412052.1	+	8	1308	c.846G>A	c.(844-846)ctG>ctA	p.L282L	ATRIP_ENST00000320211.3_Silent_p.L375L|ATRIP_ENST00000346691.4_Silent_p.L375L|ATRIP_ENST00000357105.6_Silent_p.L248L	NM_001271023.1	NP_001257952.1	Q8WXE1	ATRIP_HUMAN	ATR interacting protein	375					DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|cervix(2)|endometrium(1)|large_intestine(6)|lung(8)|ovary(3)|prostate(1)	22				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TCTCAGCCCTGAGAGAAGCAC	0.512000								Other conserved DNA damage response genes					34	61					0	0	0.003271	0	0
PHLPP1	23239	broad.mit.edu	37	18	60384439	60384439	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:60384439T>G	ENST00000262719.5	+	1	1757	c.1523T>G	c.(1522-1524)gTg>gGg	p.V508G	PHLPP1_ENST00000400316.4_5'UTR			O60346	PHLP1_HUMAN	PH domain and leucine rich repeat protein phosphatase 1	508					apoptosis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling	cytosol|membrane|nucleus	metal ion binding|protein serine/threonine phosphatase activity			endometrium(2)|kidney(2)|lung(13)	17						CTGTGGAGGGTGCAGGAGGAA	0.582000													11	21					0	0	0.000978	0	0
SLC22A11	55867	broad.mit.edu	37	11	64337277	64337277	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:64337277C>T	ENST00000301891.4	+	9	1910	c.1536C>T	c.(1534-1536)ctC>ctT	p.L512L	SLC22A11_ENST00000377585.3_Silent_p.L404L|SLC22A11_ENST00000377581.3_Intron	NM_018484.2	NP_060954.1	Q9NSA0	S22AB_HUMAN	solute carrier family 22 (organic anion/urate transporter), member 11	512					urate metabolic process	apical plasma membrane|external side of plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(3)|endometrium(3)|kidney(2)|large_intestine(5)|lung(6)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	23					Probenecid(DB01032)	TGTTCTTCCTCCCGGAGACCC	0.622000													31	7					0	0	0.002445	0	0
HSPD1	3329	broad.mit.edu	37	2	198353733	198353733	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:198353733A>C	ENST00000388968.3	-	9	1475	c.1208T>G	c.(1207-1209)gTg>gGg	p.V403G	HSPD1_ENST00000345042.2_Missense_Mutation_p.V403G	NM_002156.4	NP_002147.2	P10809	CH60_HUMAN	heat shock 60kDa protein 1 (chaperonin)	403					'de novo' protein folding|activation of caspase activity|B cell cytokine production|B cell proliferation|chaperone-mediated protein complex assembly|interspecies interaction between organisms|isotype switching to IgG isotypes|MyD88-dependent toll-like receptor signaling pathway|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of interferon-alpha production|positive regulation of interferon-gamma production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of macrophage activation|positive regulation of T cell activation|positive regulation of T cell mediated immune response to tumor cell|protein maturation|protein refolding|protein stabilization|response to unfolded protein|T cell activation	cell surface|coated pit|coated vesicle|cytosol|early endosome|extracellular space|lipopolysaccharide receptor complex|mitochondrial inner membrane|mitochondrial matrix|stored secretory granule	ATP binding|ATPase activity|cell surface binding|chaperone binding|DNA replication origin binding|lipopolysaccharide binding|p53 binding|single-stranded DNA binding			NS(1)|breast(3)|endometrium(2)|large_intestine(3)|lung(7)|skin(1)	17			Epithelial(96;0.225)			TACCTTCAGCACAGCCACTCC	0.363000													20	41					0	0	0.002299	0	0
NUP210L	91181	broad.mit.edu	37	1	154018578	154018578	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:154018578C>T	ENST00000368559.3	-	27	3734	c.3663G>A	c.(3661-3663)agG>agA	p.R1221R	NUP210L_ENST00000271854.3_Silent_p.R1221R|NUP210L_ENST00000368553.1_Silent_p.R154R	NM_207308.2	NP_997191.2	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like	1221						integral to membrane				NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|lung(34)|ovary(4)|pancreas(1)|prostate(2)|skin(6)|urinary_tract(2)	80	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			CCAATACATCCCTTTTGCTCA	0.398000													26	32					0	0	0.001512	0	0
DSG3	1830	broad.mit.edu	37	18	29046601	29046601	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:29046601C>T	ENST00000257189.4	+	11	1603	c.1520C>T	c.(1519-1521)cCt>cTt	p.P507L		NM_001944.2	NP_001935.2	P32926	DSG3_HUMAN	desmoglein 3	507					cellular component disassembly involved in apoptosis|homophilic cell adhesion	cytosol|desmosome|integral to membrane	calcium ion binding			breast(1)|central_nervous_system(2)|cervix(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(28)|ovary(4)|prostate(1)|skin(8)|upper_aerodigestive_tract(1)	62			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			AGTTCTTCACCTTCCGTGGTT	0.443000													34	52					0	0	0.002445	0	0
OR5F1	338674	broad.mit.edu	37	11	55761646	55761646	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:55761646C>T	ENST00000278409.1	-	1	455	c.456G>A	c.(454-456)ggG>ggA	p.G152G		NM_003697.1	NP_003688.1	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F, member 1	152					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|kidney(1)|large_intestine(11)|liver(1)|lung(33)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	58	Esophageal squamous(21;0.00448)					AGTTCAGCAACCCTGCAGCAA	0.507000													23	77					0	0	0.002780	0	0
C1orf173	127254	broad.mit.edu	37	1	75036964	75036964	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:75036964C>T	ENST00000326665.5	-	14	4648	c.4430G>A	c.(4429-4431)gGa>gAa	p.G1477E	C1orf173_ENST00000433746.2_5'UTR	NM_001002912.4	NP_001002912.4	Q5RHP9	CA173_HUMAN	chromosome 1 open reading frame 173	1477	Glu-rich.									NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(23)|lung(123)|ovary(3)|prostate(10)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)	184						CCGTGATAATCCTAATCGGAA	0.552000													39	46					0	0	0.006999	0	0
MMP15	4324	broad.mit.edu	37	16	58078993	58078993	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:58078993C>T	ENST00000219271.3	+	10	2438	c.1653C>T	c.(1651-1653)tcC>tcT	p.S551S		NM_002428.2	NP_002419.1	P51511	MMP15_HUMAN	matrix metallopeptidase 15 (membrane-inserted)	551	Hemopexin-like 4.				protein modification process|proteolysis	extracellular matrix|integral to plasma membrane	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|protein binding|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	18						ACCCCAAGTCCATCCTGCGGG	0.657000													5	14					0	0	0.000602	0	0
INF2	64423	broad.mit.edu	37	14	105174858	105174858	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:105174858C>T	ENST00000392634.4	+	9	1933	c.1821C>T	c.(1819-1821)tcC>tcT	p.S607S	INF2_ENST00000330634.7_Silent_p.S607S	NM_022489.3	NP_071934.3	Q27J81	INF2_HUMAN	inverted formin, FH2 and WH2 domain containing	607	FH2.				actin cytoskeleton organization	endoplasmic reticulum|nucleus|perinuclear region of cytoplasm	actin binding|Rho GTPase binding			large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	8		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00188)|OV - Ovarian serous cystadenocarcinoma(23;0.0191)|Epithelial(46;0.047)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.176)		GACTATTCTCCTTCCCTGCAG	0.687000											OREG0022959	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	14	13					0	0	0.003163	0	0
ANKMY1	51281	broad.mit.edu	37	2	241463561	241463561	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:241463561G>A	ENST00000391987.1	-	8	1672	c.1306C>T	c.(1306-1308)Ccg>Tcg	p.P436S	ANKMY1_ENST00000405002.1_Missense_Mutation_p.P206S|ANKMY1_ENST00000536462.1_Missense_Mutation_p.P248S|ANKMY1_ENST00000406958.1_Intron|ANKMY1_ENST00000405523.3_Missense_Mutation_p.P295S|ANKMY1_ENST00000373318.2_Missense_Mutation_p.P295S|ANKMY1_ENST00000361678.4_Missense_Mutation_p.P295S|ANKMY1_ENST00000401804.1_Missense_Mutation_p.P525S|ANKMY1_ENST00000373320.4_Missense_Mutation_p.P206S|ANKMY1_ENST00000403283.1_Missense_Mutation_p.P374S|ANKMY1_ENST00000272972.3_Missense_Mutation_p.P436S			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	436							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		TTCACCAACGGGGAGTCCCCC	0.627000													12	9					0	0	0.001368	0	0
SPHKAP	80309	broad.mit.edu	37	2	228882638	228882638	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:228882638A>C	ENST00000392056.3	-	7	2978	c.2932T>G	c.(2932-2934)Tcc>Gcc	p.S978A	SPHKAP_ENST00000344657.5_Missense_Mutation_p.S978A	NM_001142644.1	NP_001136116.1	Q2M3C7	SPKAP_HUMAN	SPHK1 interactor, AKAP domain containing	978						cytoplasm	protein binding			NS(5)|breast(5)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(12)|large_intestine(25)|lung(86)|ovary(6)|pancreas(1)|prostate(6)|skin(17)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	185		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTCTTCAAGGATCGGCAGGGT	0.547000													32	15					0	0	0.002445	0	0
CD84	8832	broad.mit.edu	37	1	160523164	160523164	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:160523164C>T	ENST00000311224.4	-	4	830	c.764G>A	c.(763-765)aGg>aAg	p.R255K	CD84_ENST00000368051.3_Intron|CD84_ENST00000534968.1_Intron|RP11-528G1.2_ENST00000446952.1_RNA|CD84_ENST00000368054.3_Intron|CD84_ENST00000368048.3_Intron	NM_001184879.1	NP_001171808.1	Q9UIB8	SLAF5_HUMAN	CD84 molecule	255					blood coagulation|defense response|homophilic cell adhesion|leukocyte migration	integral to plasma membrane	receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(1)	24	all_cancers(52;3.62e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.0175)			TGGGAAAATCCTACCTTGTCT	0.463000													15	50					0	0	0.003163	0	0
RELN	5649	broad.mit.edu	37	7	103236980	103236980	+	Silent	SNP	G	G	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:103236980G>C	ENST00000428762.1	-	25	3621	c.3462C>G	c.(3460-3462)ctC>ctG	p.L1154L	RELN_ENST00000424685.2_Silent_p.L1154L|RELN_ENST00000343529.5_Silent_p.L1154L	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	1154					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		TGTACTGAAGGAGGACGCCCT	0.522000													56	63					0	0	0.003610	0	0
LAMC2	3918	broad.mit.edu	37	1	183196822	183196822	+	Silent	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:183196822C>G	ENST00000264144.4	+	10	1523	c.1458C>G	c.(1456-1458)ccC>ccG	p.P486P	LAMC2_ENST00000493293.1_Silent_p.P486P	NM_005562.2	NP_005553.2	Q13753	LAMC2_HUMAN	laminin, gamma 2	486	Laminin EGF-like 6.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding	p.P486P(1)		breast(2)|endometrium(6)|kidney(8)|large_intestine(11)|lung(18)|ovary(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	55						ACTGCCCTCCCGGGGTCACCG	0.587000													8	23					0	0	0.003080	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766314	77766314	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:77766314G>A	ENST00000521891.2	+	10	7605	c.7157G>A	c.(7156-7158)gGg>gAg	p.G2386E	ZFHX4_ENST00000050961.6_Missense_Mutation_p.G2341E|ZFHX4_ENST00000455469.2_Missense_Mutation_p.G2341E|ZFHX4_ENST00000518282.1_Missense_Mutation_p.G2360E	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2341	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			TCTGGCTCTGGGACCAGCACC	0.522000										HNSCC(33;0.089)			11	74					0	0	0.000673	0	0
ZNF91	7644	broad.mit.edu	37	19	23543137	23543137	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:23543137A>C	ENST00000300619.7	-	4	2849	c.2644T>G	c.(2644-2646)Tcc>Gcc	p.S882A	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.S850A	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	882						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding						all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				TCACTCTTGGAAGGTTTCTCT	0.358000													11	16					0	0	0.000978	0	0
TMEM132B	114795	broad.mit.edu	37	12	125834710	125834710	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:125834710C>T	ENST00000299308.3	+	2	773	c.765C>T	c.(763-765)gcC>gcT	p.A255A		NM_052907.2	NP_443139.2	Q14DG7	T132B_HUMAN	transmembrane protein 132B	255						integral to membrane				NS(1)|breast(9)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(11)|liver(1)|lung(45)|ovary(5)|pancreas(1)|prostate(4)|skin(15)|upper_aerodigestive_tract(3)|urinary_tract(1)	107	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		CGTTTCCAGCCCGAGAGAGGA	0.577000													31	85					0	0	0.002096	0	0
DENND3	22898	broad.mit.edu	37	8	142146754	142146754	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:142146754C>T	ENST00000519811.1	+	2	319	c.249C>T	c.(247-249)tcC>tcT	p.S83S	DENND3_ENST00000424248.1_Silent_p.S3S|DENND3_ENST00000518347.1_Silent_p.S83S|DENND3_ENST00000262585.2_Silent_p.S3S			A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	3	UDENN.									breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(19)|ovary(1)|prostate(3)|skin(4)|stomach(2)|urinary_tract(1)	55	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			GGATGCGCTCCTTGAGAAAGA	0.612000													4	33					0	0	0.000248	0	0
CYP21A1P	1590	broad.mit.edu	37	6	31975481	31975481	+	RNA	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31975481G>A	ENST00000342991.6	+	0	1404					NR_040090.1		Q5ST44	Q5ST44_HUMAN									electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen										GCTAGACCACGAACTGGGCCC	0.672000													46	385					0	0	0.003610	0	0
ABCG4	64137	broad.mit.edu	37	11	119027719	119027719	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:119027719C>T	ENST00000307417.3	+	9	1427	c.1063C>T	c.(1063-1065)Cct>Tct	p.P355S	ABCG4_ENST00000531739.1_Missense_Mutation_p.P355S|AP002956.1_ENST00000599663.1_Intron|ABCG4_ENST00000449422.2_Missense_Mutation_p.P355S	NM_022169.4	NP_071452.2	Q9H172	ABCG4_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 4	355					cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(28)|ovary(2)|prostate(1)|skin(1)	44	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		CCCTCCTTGTCCTCCGGTGAG	0.617000													51	6					0	0	0.003610	0	0
SPRR2G	6706	broad.mit.edu	37	1	153122541	153122541	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:153122541G>A	ENST00000368748.4	-	2	84	c.46C>T	c.(46-48)Cct>Tct	p.P16S		NM_001014291.3	NP_001014313.1	Q9BYE4	SPR2G_HUMAN	small proline-rich protein 2G	16					keratinization	cornified envelope|cytoplasm				endometrium(1)|lung(1)|skin(1)	3	all_lung(78;1.78e-30)|Lung NSC(65;7.29e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GGGCACACAGGAGGTGGCTGG	0.572000													33	105					0	0	0.004878	0	0
MATN2	4147	broad.mit.edu	37	8	99045812	99045812	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:99045812G>A	ENST00000254898.5	+	18	2971	c.2740G>A	c.(2740-2742)Gat>Aat	p.D914N	MATN2_ENST00000524308.1_Missense_Mutation_p.D873N|MATN2_ENST00000522025.2_Missense_Mutation_p.D630N|MATN2_ENST00000520016.1_Missense_Mutation_p.D914N|RPL30_ENST00000518164.1_Intron|MATN2_ENST00000521689.1_Missense_Mutation_p.D895N	NM_002380.3|NM_030583.2	NP_002371.3|NP_085072.2	O00339	MATN2_HUMAN	matrilin 2	914						proteinaceous extracellular matrix	calcium ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(17)|ovary(2)|urinary_tract(1)	31	Breast(36;1.43e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.244)			AGAAAAACACGATCAATGCAA	0.388000													7	28					0	0	0.004482	0	0
COL4A4	1286	broad.mit.edu	37	2	227922200	227922200	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:227922200C>T	ENST00000396625.3	-	29	2707	c.2500G>A	c.(2500-2502)Ggg>Agg	p.G834R	COL4A4_ENST00000329662.7_Missense_Mutation_p.G834R	NM_000092.4	NP_000083.3	P53420	CO4A4_HUMAN	collagen, type IV, alpha 4	834	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			breast(2)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(15)|lung(35)|ovary(5)|pancreas(3)|prostate(2)|skin(12)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	98		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		CCTGGTATCCCTGGAGCACCT	0.537000													7	4					0	0	0.003080	0	0
PCLO	27445	broad.mit.edu	37	7	82584366	82584366	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:82584366G>A	ENST00000423517.2	-	5	6240	c.5903C>T	c.(5902-5904)tCg>tTg	p.S1968L	PCLO_ENST00000333891.8_Missense_Mutation_p.S1968L	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1899					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						GCCATCTACCGATCCATTGTA	0.363000													47	64					0	0	0.003610	0	0
SCN9A	6335	broad.mit.edu	37	2	167162316	167162316	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:167162316G>A	ENST00000375387.4	-	5	925	c.585C>T	c.(583-585)gtC>gtT	p.V195V	SCN9A_ENST00000409435.1_Silent_p.V194V|SCN9A_ENST00000409672.1_Silent_p.V194V|SCN9A_ENST00000303354.6_Silent_p.V195V			Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha subunit	194						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	AAACAATGACGACAAAATCCA	0.398000													23	32					0	0	0.003330	0	0
TJAP1	93643	broad.mit.edu	37	6	43473457	43473457	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43473457C>T	ENST00000372444.2	+	11	1941	c.1508C>T	c.(1507-1509)tCc>tTc	p.S503F	TJAP1_ENST00000372445.5_Missense_Mutation_p.S513F|TJAP1_ENST00000438588.2_Missense_Mutation_p.S513F|TJAP1_ENST00000372449.1_Missense_Mutation_p.S513F|TJAP1_ENST00000436109.2_Missense_Mutation_p.S503F|TJAP1_ENST00000372452.1_Missense_Mutation_p.S503F|TJAP1_ENST00000259751.1_Missense_Mutation_p.S503F|TJAP1_ENST00000483640.1_3'UTR	NM_001146018.1	NP_001139490.1	Q5JTD0	TJAP1_HUMAN	tight junction associated protein 1 (peripheral)	513						Golgi apparatus|tight junction	protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(11)|ovary(1)|urinary_tract(2)	21	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0122)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CCAGGCACTTCCCACACCGAG	0.662000													5	34					0	0	0.001168	0	0
DNAH10	196385	broad.mit.edu	37	12	124284800	124284800	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:124284800G>A	ENST00000409039.3	+	14	1998	c.1973G>A	c.(1972-1974)aGg>aAg	p.R658K		NM_207437.3	NP_997320.2	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	658	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(14)|ovary(4)|prostate(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		ACTTTAGAAAGGGGAGCTGTT	0.478000													10	39					0	0	0.001855	0	0
VWCE	220001	broad.mit.edu	37	11	61048115	61048115	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:61048115C>T	ENST00000335613.5	-	9	1691	c.1305G>A	c.(1303-1305)ggG>ggA	p.G435G		NM_152718.2	NP_689931.2	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	435	VWFC 1.					extracellular region	calcium ion binding			biliary_tract(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(17)|ovary(3)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	37						ATGGGCAGCACCCACCATCTC	0.552000													12	19					0	0	0.004007	0	0
GRM1	2911	broad.mit.edu	37	6	146720176	146720176	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:146720176C>T	ENST00000392299.2	+	8	2471	c.2001C>T	c.(1999-2001)tcC>tcT	p.S667S	GRM1_ENST00000507907.1_Silent_p.S667S|GRM1_ENST00000282753.1_Silent_p.S667S|GRM1_ENST00000492807.2_Silent_p.S667S|GRM1_ENST00000355289.4_Silent_p.S667S|GRM1_ENST00000361719.2_Silent_p.S667S			Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	667					synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	TTGGCCTCTCCTCTGCGATGT	0.527000													88	127					0	0	0.003610	0	0
FKBP15	23307	broad.mit.edu	37	9	115932877	115932877	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:115932877G>A	ENST00000238256.3	-	25	2808	c.2691C>T	c.(2689-2691)tcC>tcT	p.S897S		NM_015258.1	NP_056073.1	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	897					endocytosis|protein folding	axon|early endosome	actin binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(9)|ovary(3)|urinary_tract(1)	26						CTCTCCGTAAGGACTGGAACA	0.443000													39	69					0	0	0.002222	0	0
CELSR3	1951	broad.mit.edu	37	3	48682556	48682556	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:48682556G>A	ENST00000544264.1	-	26	8179	c.7899C>T	c.(7897-7899)taC>taT	p.Y2633Y	CELSR3_ENST00000164024.4_Silent_p.Y2628Y			Q9NYQ7	CELR3_HUMAN	cadherin, EGF LAG seven-pass G-type receptor 3	2628					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(9)|prostate(6)|skin(7)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(5)	83				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCTGCATGCGGTAGAGGTGCA	0.662000													17	25					0	0	0.006122	0	0
ANKRD20A19P	400110	broad.mit.edu	37	13	24519992	24519992	+	RNA	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:24519992G>A	ENST00000442969.1	-	0	929																											GCTGTTCCGCGTCCCGGATTC	0.677000													3	3					0	0	0.004672	0	0
OR8A1	390275	broad.mit.edu	37	11	124440146	124440146	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:124440146G>A	ENST00000284287.3	+	1	254	c.182G>A	c.(181-183)gGc>gAc	p.G61D		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	61					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		GGGAACCTGGGCATGATCACT	0.502000													20	45					0	0	0.007413	0	0
WDR75	84128	broad.mit.edu	37	2	190322059	190322059	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:190322059G>A	ENST00000314761.4	+	6	581	c.521G>A	c.(520-522)cGg>cAg	p.R174Q		NM_032168.1	NP_115544.1	Q8IWA0	WDR75_HUMAN	WD repeat domain 75	174						nucleolus				breast(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(1)	25			OV - Ovarian serous cystadenocarcinoma(117;0.00105)|Epithelial(96;0.0129)|all cancers(119;0.0456)			GCTGCAGTACGGGAATTTTAC	0.254000													13	15					0	0	0.001216	0	0
IGHV4-59	28392	broad.mit.edu	37	14	107083655	107083655	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:107083655C>T	ENST00000455737.1	-	0	70																											GGAGCTGCCACCAGGAGAAGG	0.517000													11	18					0	0	0.000978	0	0
NMT1	4836	broad.mit.edu	37	17	43171163	43171163	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:43171163C>T	ENST00000592782.1	+	5	627	c.496C>T	c.(496-498)Cgt>Tgt	p.R166C	NMT1_ENST00000258960.2_Missense_Mutation_p.R166C|NMT1_ENST00000590114.1_3'UTR			P30419	NMT1_HUMAN	N-myristoyltransferase 1	166					activation of pro-apoptotic gene products|induction of apoptosis by intracellular signals|N-terminal protein myristoylation|protein lipoylation	actin cytoskeleton|cell junction|cytosol	glycylpeptide N-tetradecanoyltransferase activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(1)|lung(1)|prostate(1)	8		Prostate(33;0.155)				CCTGGGCGATCGTGGTGTGGT	0.602000													13	28					0	0	0.004007	0	0
DOPEY1	23033	broad.mit.edu	37	6	83810448	83810448	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:83810448C>T	ENST00000349129.2	+	4	423	c.163C>T	c.(163-165)Caa>Taa	p.Q55*	DOPEY1_ENST00000237163.5_Nonsense_Mutation_p.Q55*|DOPEY1_ENST00000536812.1_Nonsense_Mutation_p.Q55*|DOPEY1_ENST00000369739.3_Nonsense_Mutation_p.Q55*	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	55					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TGCAAAGTACCAAGTAGTACC	0.363000													46	71					0	0	0.003214	0	0
MIER2	54531	broad.mit.edu	37	19	312226	312226	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:312226A>T	ENST00000264819.4	-	9	864	c.854T>A	c.(853-855)cTg>cAg	p.L285Q		NM_017550.1	NP_060020.1	Q8N344	MIER2_HUMAN	mesoderm induction early response 1, family member 2	285	ELM2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			endometrium(4)|kidney(1)|large_intestine(5)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22		all_cancers(10;1.05e-30)|all_epithelial(18;3.04e-19)|Acute lymphoblastic leukemia(61;4.36e-14)|all_hematologic(61;4.84e-09)|Lung NSC(49;2.49e-05)|all_lung(49;4.36e-05)|Breast(49;0.000304)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCCTTCGCAGGGCCTCCTC	0.632000													4	14					0	0	0.001168	0	0
BSN	8927	broad.mit.edu	37	3	49701892	49701892	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:49701892G>A	ENST00000296452.4	+	9	11759	c.11645G>A	c.(11644-11646)gGg>gAg	p.G3882E		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	3882					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GGAACCCCAGGGGCTCCCGCC	0.622000													30	74					0	0	0.001786	0	0
SFRP1	6422	broad.mit.edu	37	8	41164341	41164341	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:41164341C>T	ENST00000379845.3	-	1	168	c.36G>A	c.(34-36)cgG>cgA	p.R12R	SFRP1_ENST00000220772.3_Intron			Q8N474	SFRP1_HUMAN	secreted frizzled-related protein 1	0					brain development|canonical Wnt receptor signaling pathway|cellular response to BMP stimulus|cellular response to estradiol stimulus|cellular response to fibroblast growth factor stimulus|cellular response to heparin|cellular response to hypoxia|cellular response to interleukin-1|cellular response to prostaglandin E stimulus|cellular response to starvation|cellular response to transforming growth factor beta stimulus|cellular response to tumor necrosis factor|cellular response to vitamin D|DNA fragmentation involved in apoptotic nuclear change|dorsal/ventral axis specification|hemopoietic progenitor cell differentiation|hemopoietic stem cell differentiation|menstrual cycle phase|negative regulation of androgen receptor signaling pathway|negative regulation of B cell differentiation|negative regulation of bone remodeling|negative regulation of canonical Wnt receptor signaling pathway involved in controlling type B pancreatic cell proliferation|negative regulation of cell growth|negative regulation of cell migration|negative regulation of cysteine-type endopeptidase activity|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast apoptosis|negative regulation of fibroblast proliferation|negative regulation of insulin secretion|negative regulation of ossification|negative regulation of osteoblast proliferation|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|osteoblast differentiation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell growth|positive regulation of epithelial cell proliferation|positive regulation of fat cell differentiation|positive regulation of fibroblast apoptosis|positive regulation of focal adhesion assembly|positive regulation of non-canonical Wnt receptor signaling pathway|positive regulation of Rac GTPase activity|positive regulation of smoothened signaling pathway|positive regulation of stress fiber assembly|positive regulation of transcription, DNA-dependent|regulation of angiogenesis|regulation of cell cycle process|response to drug|response to organic cyclic compound|vasculature development	cell surface|cytosol|extracellular space|plasma membrane|proteinaceous extracellular matrix	cysteine-type endopeptidase activity|drug binding|frizzled binding|heparin binding|identical protein binding|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|large_intestine(2)|liver(1)|lung(1)|skin(1)	7	Breast(1;9.19e-13)|Ovarian(28;0.00769)|Colorectal(14;0.0305)|Lung SC(25;0.211)	all_lung(54;0.0034)|Lung NSC(58;0.0134)|Hepatocellular(245;0.023)|Esophageal squamous(32;0.0559)	BRCA - Breast invasive adenocarcinoma(1;1.11e-10)|LUSC - Lung squamous cell carcinoma(45;0.00894)|COAD - Colon adenocarcinoma(11;0.0174)			CAAAAGGTGTCCGGAAGACAG	0.597000													5	15					0	0	0.000602	0	0
ASH1L	55870	broad.mit.edu	37	1	155450033	155450033	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:155450033G>A	ENST00000368346.3	-	3	3267	c.2628C>T	c.(2626-2628)tcC>tcT	p.S876S	ASH1L_ENST00000392403.3_Silent_p.S876S			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	876					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CTTGTTTGAAGGAAGGGATTT	0.418000													139	53					0	0	0.003610	0	0
SPRYD3	84926	broad.mit.edu	37	12	53468952	53468952	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:53468952G>A	ENST00000301463.4	-	4	384	c.298C>T	c.(298-300)Cct>Tct	p.P100S	SPRYD3_ENST00000547837.1_Missense_Mutation_p.P137S	NM_032840.2	NP_116229.1	Q8NCJ5	SPRY3_HUMAN	SPRY domain containing 3	100	B30.2/SPRY.									central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	17						TAGTACTGAGGGACCAGCCCC	0.582000													34	96					0	0	0.003271	0	0
SLITRK3	22865	broad.mit.edu	37	3	164905757	164905757	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:164905757G>A	ENST00000475390.1	-	2	3305	c.2862C>T	c.(2860-2862)ctC>ctT	p.L954L	SLITRK3_ENST00000241274.3_Silent_p.L954L			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	954						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						CCCTTAACTCGAGGTAATCAC	0.448000										HNSCC(40;0.11)			51	140					0	0	0.003610	0	0
GABPB2	126626	broad.mit.edu	37	1	151070367	151070367	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:151070367G>A	ENST00000368918.3	+	5	842	c.511G>A	c.(511-513)Gcc>Acc	p.A171T	GABPB2_ENST00000368916.1_Missense_Mutation_p.A171T|GABPB2_ENST00000467551.1_3'UTR|GABPB2_ENST00000368917.1_Missense_Mutation_p.A171T	NM_144618.2	NP_653219.1	Q8TAK5	GABP2_HUMAN	GA binding protein transcription factor, beta subunit 2	171					positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	protein heterodimerization activity|transcription regulatory region DNA binding			breast(1)|endometrium(2)|large_intestine(3)|liver(2)|lung(7)	15				all cancers(107;7.17e-05)|GBM - Glioblastoma multiforme(94;0.000662)		TCCAGAGAGAGCCAACCCTGT	0.433000													29	42					0	0	0.002096	0	0
CKAP5	9793	broad.mit.edu	37	11	46784543	46784543	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:46784543G>A	ENST00000529230.1	-	30	3920	c.3874C>T	c.(3874-3876)Ccc>Tcc	p.P1292S	CKAP5_ENST00000354558.3_Missense_Mutation_p.P1292S|CKAP5_ENST00000312055.5_Missense_Mutation_p.P1292S|CKAP5_ENST00000415402.1_Missense_Mutation_p.P1292S			Q14008	CKAP5_HUMAN	cytoskeleton associated protein 5	1292					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding			breast(1)|cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(13)|ovary(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	43						ACAAGATAGGGGATGAAGGAA	0.403000													18	34					0	0	0.001216	0	0
MMP24	10893	broad.mit.edu	37	20	33842507	33842507	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:33842507C>T	ENST00000246186.6	+	4	852	c.767C>T	c.(766-768)aCc>aTc	p.T256I	MMP24-AS1_ENST00000456350.1_RNA|EDEM2_ENST00000540582.1_Intron|MMP24-AS1_ENST00000566203.1_RNA|MMP24-AS1_ENST00000438751.1_RNA|MMP24-AS1_ENST00000433764.1_RNA|MMP24-AS1_ENST00000454184.1_RNA	NM_006690.3	NP_006681.1	Q9Y5R2	MMP24_HUMAN	matrix metallopeptidase 24 (membrane-inserted)	256					proteolysis	integral to plasma membrane|proteinaceous extracellular matrix	calcium ion binding|enzyme activator activity|metalloendopeptidase activity|zinc ion binding			NS(1)|endometrium(3)|large_intestine(1)|lung(2)|prostate(2)|skin(5)	14			BRCA - Breast invasive adenocarcinoma(18;0.00252)			GGAGGAGACACCCACTTTGAC	0.562000													36	123					0	0	0.005524	0	0
PDE9A	5152	broad.mit.edu	37	21	44174108	44174108	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:44174108C>T	ENST00000291539.6	+	10	804	c.744C>T	c.(742-744)ctC>ctT	p.L248L	PDE9A_ENST00000349112.3_Silent_p.L120L|PDE9A_ENST00000335440.6_Silent_p.L146L|PDE9A_ENST00000380328.2_Silent_p.L195L|PDE9A_ENST00000335512.4_Silent_p.L188L|PDE9A_ENST00000328862.6_Silent_p.L222L|PDE9A_ENST00000398229.3_Silent_p.L114L|PDE9A_ENST00000398232.3_Silent_p.L181L|PDE9A_ENST00000398227.3_Silent_p.L88L|PDE9A_ENST00000470987.1_3'UTR|PDE9A_ENST00000398225.3_Silent_p.L207L|PDE9A_ENST00000539837.1_Silent_p.L120L|PDE9A_ENST00000398236.3_Silent_p.L162L|PDE9A_ENST00000398234.3_Silent_p.L147L|PDE9A_ENST00000398224.3_Silent_p.L121L	NM_002606.2	NP_002597.1	O76083	PDE9A_HUMAN	phosphodiesterase 9A	248					platelet activation|signal transduction	cytosol|endoplasmic reticulum|Golgi apparatus|perinuclear region of cytoplasm|ruffle membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding|protein binding			breast(1)|endometrium(4)|large_intestine(6)|lung(8)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	27						AGTACCTGCTCTCTCCAGAGA	0.577000													6	13					0	0	0.003080	0	0
TTI1	9675	broad.mit.edu	37	20	36640943	36640943	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:36640943G>A	ENST00000373448.2	-	3	1514	c.1276C>T	c.(1276-1278)Cag>Tag	p.Q426*	TTI1_ENST00000487362.1_Intron|TTI1_ENST00000373447.3_Nonsense_Mutation_p.Q426*|TTI1_ENST00000449821.1_Nonsense_Mutation_p.Q426*	NM_014657.1	NP_055472.1	O43156	TTI1_HUMAN	TELO2 interacting protein 1	426							binding			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(6)|liver(1)|lung(18)|ovary(3)|pancreas(1)|prostate(3)|skin(3)	47						GAAAGCCGCTGGAGATGGGCC	0.458000													16	75					0	0	0.004990	0	0
NKX2-2	4821	broad.mit.edu	37	20	21492893	21492893	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:21492893G>A	ENST00000377142.4	-	2	846	c.490C>T	c.(490-492)Ctc>Ttc	p.L164F	NKX2-2-AS1_ENST00000549659.1_RNA	NM_002509.3	NP_002500.1	O95096	NKX22_HUMAN	NK2 homeobox 2	164					brain development|positive regulation of sequence-specific DNA binding transcription factor activity	nucleus	chromatin binding|core promoter proximal region DNA binding|transcription coactivator activity			endometrium(2)|kidney(2)|large_intestine(2)|lung(10)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	21						AGGCGGATGAGGCTGGCCAGG	0.657000													16	41					0	0	0.004990	0	0
ENPP7	339221	broad.mit.edu	37	17	77705076	77705076	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:77705076C>T	ENST00000328313.5	+	1	396	c.175C>T	c.(175-177)Cga>Tga	p.R59*		NM_178543.3	NP_848638.2	Q6UWV6	ENPP7_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase 7	59					negative regulation of cell proliferation|negative regulation of DNA replication|sphingomyelin metabolic process	Golgi apparatus|integral to membrane|microvillus	sphingomyelin phosphodiesterase activity	p.R59*(1)		breast(1)|central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(6)|skin(3)	34			OV - Ovarian serous cystadenocarcinoma(97;0.016)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CGCCATGGCCCGAGACGGGGT	0.632000													17	27					0	0	0.004990	0	0
ZNF555	148254	broad.mit.edu	37	19	2853905	2853905	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:2853905G>A	ENST00000334241.4	+	4	1980	c.1842G>A	c.(1840-1842)caG>caA	p.Q614Q	ZNF555_ENST00000591539.1_Silent_p.Q613Q|AC006130.3_ENST00000589365.1_RNA	NM_001172775.1|NM_152791.4	NP_001166246.1|NP_690004.4	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	614					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(3)|urinary_tract(4)	23				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGTCACACCAGGAGAGAGATC	0.393000													29	24					0	0	0.006320	0	0
CCDC116	164592	broad.mit.edu	37	22	21988757	21988757	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:21988757C>G	ENST00000292779.3	+	3	680	c.519C>G	c.(517-519)agC>agG	p.S173R		NM_152612.2	NP_689825.2	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	173										endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(5)	22	Colorectal(54;0.105)					GCTCCCACAGCCGGGACAGTG	0.607000													17	45					0	0	0.007413	0	0
LRRTM1	347730	broad.mit.edu	37	2	80530636	80530636	+	Silent	SNP	G	G	A	rs138746641		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:80530636G>A	ENST00000295057.3	-	2	965	c.309C>T	c.(307-309)tcC>tcT	p.S103S	CTNNA2_ENST00000402739.4_Intron|CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000496558.1_Intron|LRRTM1_ENST00000409148.1_Silent_p.S103S|CTNNA2_ENST00000540488.1_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	103						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						CCCCCTGCACGGAGCAGATGT	0.592000										HNSCC(69;0.2)			37	82					0	0	0.006230	0	0
RP1L1	94137	broad.mit.edu	37	8	10465835	10465835	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:10465835G>A	ENST00000382483.3	-	4	5996	c.5773C>T	c.(5773-5775)Ctg>Ttg	p.L1925L		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1925					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		TCAGTCTCCAGGGCCTCTACA	0.627000													36	95					0	0	0.003755	0	0
DNAH5	1767	broad.mit.edu	37	5	13716662	13716662	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:13716662G>A	ENST00000265104.4	-	74	12947	c.12843C>T	c.(12841-12843)ttC>ttT	p.F4281F		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	4281					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					GGTAAAAACTGAAATCTGGTC	0.358000									Kartagener syndrome				17	62					0	0	0.006122	0	0
DDR1	780	broad.mit.edu	37	6	30865183	30865183	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:30865183C>T	ENST00000324771.8	+	17	2573	c.2025C>T	c.(2023-2025)atC>atT	p.I675I	DDR1_ENST00000454612.2_Silent_p.I638I|DDR1_ENST00000376569.3_Silent_p.I638I|DDR1_ENST00000376575.3_Silent_p.I681I|DDR1_ENST00000376570.4_Silent_p.I638I|DDR1_ENST00000452441.1_Silent_p.I675I|DDR1_ENST00000418800.2_Silent_p.I638I|DDR1_ENST00000513240.1_Silent_p.I681I|DDR1_ENST00000508312.1_Silent_p.I656I|DDR1_ENST00000361741.4_Silent_p.I342I|DDR1_ENST00000446312.1_3'UTR|DDR1_ENST00000376567.2_Silent_p.I638I|DDR1_ENST00000376568.3_Silent_p.I675I			Q08345	DDR1_HUMAN	discoidin domain receptor tyrosine kinase 1	675	Protein kinase.				cell adhesion|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region|integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(14)|ovary(1)|prostate(1)|skin(1)	29					Imatinib(DB00619)	AGGTGAAGATCATGTCGAGGC	0.587000													10	95					0	0	0.006214	0	0
SRRM2	23524	broad.mit.edu	37	16	2817499	2817499	+	Missense_Mutation	SNP	C	C	T	rs61747731		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:2817499C>T	ENST00000301740.8	+	11	7519	c.6970C>T	c.(6970-6972)Ccc>Tcc	p.P2324S		NM_016333.3	NP_057417.3	Q9UQ35	SRRM2_HUMAN	serine/arginine repetitive matrix 2	2324	Ala-rich.|Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(20)|lung(34)|ovary(6)|pancreas(3)|prostate(2)|skin(6)|upper_aerodigestive_tract(3)|urinary_tract(7)	105						TGCAAACTATCCCTCCAGCTC	0.602000													65	84					0	0	0.003610	0	0
KRTAP10-1	386677	broad.mit.edu	37	21	45959332	45959332	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:45959332G>A	ENST00000400375.1	-	1	746	c.702C>T	c.(700-702)ctC>ctT	p.L234L	TSPEAR_ENST00000323084.4_Intron|TSPEAR_ENST00000397916.1_Intron	NM_198691.2	NP_941964.2	P60331	KR101_HUMAN	keratin associated protein 10-1	234	24 X 5 AA repeats of C-C-X(3).					keratin filament				breast(1)|central_nervous_system(1)|endometrium(1)|lung(3)|prostate(4)|skin(1)	11						GGCGGCAGAGGAGGGACACGG	0.687000													21	19					0	0	0.002299	0	0
NPSR1	387129	broad.mit.edu	37	7	34851465	34851465	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:34851465C>T	ENST00000360581.1	+	4	596	c.468C>T	c.(466-468)ttC>ttT	p.F156F	NPSR1_ENST00000359791.1_Silent_p.F156F|NPSR1_ENST00000531252.1_Silent_p.F145F|NPSR1_ENST00000381539.3_Silent_p.F156F|NPSR1_ENST00000381542.1_Intron	NM_207172.1	NP_997055.1	Q6W5P4	NPSR1_HUMAN	neuropeptide S receptor 1	156						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(14)|pancreas(1)|skin(7)	31					Halothane(DB01159)	CCATGAAGTTCCTTCAAGGAG	0.443000													38	34					0	0	0.006230	0	0
MTMR8	55613	broad.mit.edu	37	X	63564991	63564991	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:63564991G>A	ENST00000374852.3	-	7	866	c.799C>T	c.(799-801)Cgc>Tgc	p.R267C	MTMR8_ENST00000453546.1_Missense_Mutation_p.R267C|MTMR8_ENST00000478487.1_5'UTR	NM_017677.3	NP_060147.2	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	267	Myotubularin phosphatase.					nuclear envelope	protein tyrosine phosphatase activity	p.0?(1)		breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(8)|lung(10)|ovary(2)|skin(3)	37						AATCTGAAGCGAATGTTGGCA	0.488000													26	4					0	0	0.004656	0	0
MYCBP2	23077	broad.mit.edu	37	13	77817289	77817289	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:77817289G>A	ENST00000407578.2	-	17	2800	c.2534C>T	c.(2533-2535)cCa>cTa	p.P845L	MYCBP2_ENST00000360084.5_5'UTR|MYCBP2_ENST00000544440.2_Missense_Mutation_p.P807L|MYCBP2_ENST00000357337.6_Missense_Mutation_p.P807L	NM_015057.4	NP_055872.4	O75592	MYCB2_HUMAN	MYC binding protein 2, E3 ubiquitin protein ligase	807					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(51)|ovary(5)|pancreas(2)|prostate(5)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	118		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		CCCGGGCACTGGGACAGCTAG	0.383000													17	27					0	0	0.006122	0	0
CFB	629	broad.mit.edu	37	6	31915562	31915562	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31915562C>T	ENST00000456570.1	+	17	2263	c.2208C>T	c.(2206-2208)ttC>ttT	p.F736F	CFB_ENST00000477310.1_Silent_p.F585F|CFB_ENST00000425368.2_Silent_p.F234F|CFB_ENST00000556679.1_Silent_p.F736F			P00751	CFAB_HUMAN	complement factor B	234	Peptidase S1.		A -> S (in allele FA).		complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(10)|pancreas(1)|skin(1)|urinary_tract(1)	21						CCGAAGCTTTCCTGTCTTCCC	0.552000													332	554					0	0	0.003610	0	0
OR9Q1	219956	broad.mit.edu	37	11	57947001	57947001	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57947001C>T	ENST00000335397.3	+	3	401	c.85C>T	c.(85-87)Ctc>Ttc	p.L29F		NM_001005212.3	NP_001005212.1	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q, member 1	29					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|liver(1)|lung(12)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	26		Breast(21;0.222)				CCCTCTCTTCCTCTTGTTTTT	0.453000													45	154					0	0	0.001951	0	0
BAI1	575	broad.mit.edu	37	8	143623563	143623563	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:143623563G>A	ENST00000517894.1	+	28	4862	c.3968G>A	c.(3967-3969)gGg>gAg	p.G1323E	BAI1_ENST00000323289.5_Missense_Mutation_p.G1323E			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1323					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					GTCGGTGACGGGGACATCTTC	0.672000													28	168					0	0	0.007291	0	0
ZEB1	6935	broad.mit.edu	37	10	31791374	31791374	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:31791374C>T	ENST00000446923.2	+	4	761	c.370C>T	c.(370-372)Cct>Tct	p.P124S	ZEB1_ENST00000542815.3_Missense_Mutation_p.P73S|ZEB1_ENST00000560721.2_Missense_Mutation_p.P120S|ZEB1_ENST00000320985.10_Missense_Mutation_p.P140S|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000361642.5_Missense_Mutation_p.P141S	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	140					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				TGTCATTTTTCCTGAGGCACC	0.423000													36	53					0	0	0.004289	0	0
ANKMY1	51281	broad.mit.edu	37	2	241459909	241459909	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:241459909C>T	ENST00000391987.1	-	9	1973	c.1607G>A	c.(1606-1608)cGg>cAg	p.R536Q	ANKMY1_ENST00000536462.1_Intron|ANKMY1_ENST00000406958.1_Missense_Mutation_p.R297Q|ANKMY1_ENST00000405523.3_Missense_Mutation_p.R395Q|ANKMY1_ENST00000373318.2_Missense_Mutation_p.R395Q|ANKMY1_ENST00000361678.4_Missense_Mutation_p.R395Q|ANKMY1_ENST00000401804.1_Missense_Mutation_p.R625Q|ANKMY1_ENST00000373320.4_Missense_Mutation_p.R306Q|ANKMY1_ENST00000403283.1_Missense_Mutation_p.R474Q|ANKMY1_ENST00000272972.3_Missense_Mutation_p.R536Q			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	536							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		GTCCGCGCCCCGGCGCAGCAG	0.697000													13	12					0	0	0.001855	0	0
UNC79	57578	broad.mit.edu	37	14	94063734	94063734	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:94063734C>T	ENST00000553484.1	+	24	3374	c.3220C>T	c.(3220-3222)Ctg>Ttg	p.L1074L	UNC79_ENST00000393151.2_Silent_p.L1074L|UNC79_ENST00000256339.4_Silent_p.L897L|UNC79_ENST00000555664.1_Silent_p.L1074L			Q9P2D8	UNC79_HUMAN	unc-79 homolog (C. elegans)	1074						integral to membrane				breast(3)|cervix(2)|endometrium(10)|kidney(7)|large_intestine(18)|liver(1)|lung(64)|ovary(1)|prostate(5)|skin(3)|urinary_tract(4)	118						TTGTAGATTTCTGGATATTCA	0.438000													15	32					0	0	0.004990	0	0
UMODL1	89766	broad.mit.edu	37	21	43504239	43504239	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:43504239C>T	ENST00000400427.1	+	3	545	c.149C>T	c.(148-150)cCc>cTc	p.P50L	UMODL1_ENST00000408989.2_Missense_Mutation_p.P122L|UMODL1_ENST00000408910.2_Missense_Mutation_p.P122L|UMODL1_ENST00000400424.1_Missense_Mutation_p.P50L	NM_001199527.1	NP_001186456.1	Q5DID0	UROL1_HUMAN	uromodulin-like 1	122	EMI.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						GGGGCCTGCCCCGCAGAGGGG	0.562000													49	50					0	0	0.003610	0	0
HHATL	57467	broad.mit.edu	37	3	42738627	42738627	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:42738627G>A	ENST00000441594.1	-	8	1137	c.876C>T	c.(874-876)gcC>gcT	p.A292A	HHATL_ENST00000310417.5_Silent_p.A292A	NM_020707.3	NP_065758.3	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	292					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(3)	19				KIRC - Kidney renal clear cell carcinoma(284;0.215)		GGTTTGAATAGGCTAGGCCAG	0.627000													15	29					0	0	0.004990	0	0
ANO7	50636	broad.mit.edu	37	2	242149015	242149015	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:242149015C>T	ENST00000274979.8	+	13	1589	c.1486C>T	c.(1486-1488)Cgc>Tgc	p.R496C	ANO7_ENST00000402430.3_Missense_Mutation_p.R495C	NM_001001891.3	NP_001001891.2	Q6IWH7	ANO7_HUMAN	anoctamin 7	496						cell junction|chloride channel complex|cytosol	chloride channel activity			NS(1)|central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(14)|pancreas(2)|prostate(1)|skin(3)|urinary_tract(2)	32						CCGCGCGCGCCGCATGCTGGC	0.677000													9	19					0	0	0.006214	0	0
PLRG1	5356	broad.mit.edu	37	4	155458438	155458438	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:155458438G>A	ENST00000499023.2	-	14	1611	c.1485_splice	c.e14+1	p.A495_splice	PLRG1_ENST00000393905.2_Splice_Site_p.A495_splice|PLRG1_ENST00000302078.5_Splice_Site_p.A486_splice	NM_001201564.1|NM_002669.3	NP_001188493.1|NP_002660.1	O43660	PLRG1_HUMAN	pleiotropic regulator 1	495						catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(11)|skin(1)|urinary_tract(1)	22	all_hematologic(180;0.215)	Renal(120;0.0854)				CAGAACTTACGGCTGTGTCAT	0.328000													13	14					0	0	0.001855	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141461203	141461203	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:141461203C>T	ENST00000389328.4	-	2	578	c.564G>A	c.(562-564)aaG>aaA	p.K188K	TRAPPC9_ENST00000438773.2_Silent_p.K90K|TRAPPC9_ENST00000389327.3_Silent_p.K90K	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	90					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						GTGGCCAGTCCTTGGCCGAGA	0.582000													19	85					0	0	0.001523	0	0
CCDC180	100499483	broad.mit.edu	37	9	100132244	100132244	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:100132244C>T	ENST00000375202.2	+	46	5714	c.4362C>T	c.(4360-4362)ccC>ccT	p.P1454P	CCDC180_ENST00000529487.1_Silent_p.P1454P|CCDC180_ENST00000395220.1_3'UTR|CCDC180_ENST00000357054.1_Silent_p.P1399P|RP11-23J9.4_ENST00000534123.1_RNA					coiled-coil domain containing 180																		AGCTGCTGCCCCAAGTGTGTT	0.498000													10	20					0	0	0.000978	0	0
SI	6476	broad.mit.edu	37	3	164764781	164764781	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:164764781G>A	ENST00000264382.3	-	16	1797	c.1735C>T	c.(1735-1737)Cct>Tct	p.P579S		NM_001041.3	NP_001032.2	P14410	SUIS_HUMAN	sucrase-isomaltase (alpha-glucosidase)	579	Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			NS(4)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(6)|kidney(10)|large_intestine(18)|lung(124)|ovary(9)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(16)|urinary_tract(1)	218		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	CTCTTATTAGGAAAAACTTTT	0.303000										HNSCC(35;0.089)			9	16					0	0	0.004482	0	0
ZNF568	374900	broad.mit.edu	37	19	37441101	37441101	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:37441101T>C	ENST00000415168.1	+	5	1230	c.854T>C	c.(853-855)cTt>cCt	p.L285P	ZNF568_ENST00000455427.2_Intron|ZNF568_ENST00000427117.1_Intron|ZNF568_ENST00000333987.7_Missense_Mutation_p.L349P	NM_001204837.1	NP_001191766.1	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(9)|ovary(1)	29	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			AAGCAAAATCTTATTGAGCAC	0.388000													29	59					0	0	0.001512	0	0
MUC16	94025	broad.mit.edu	37	19	9060492	9060492	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9060492G>A	ENST00000397910.4	-	3	27157	c.26954C>T	c.(26953-26955)gCt>gTt	p.A8985V		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8987	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CTCAGAGGAAGCAGGTATGGT	0.498000													62	84					0	0	0.003610	0	0
TBX20	57057	broad.mit.edu	37	7	35293225	35293225	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:35293225A>G	ENST00000408931.3	-	1	533	c.7T>C	c.(7-9)Ttc>Ctc	p.F3L		NM_001077653.2|NM_001166220.1	NP_001071121.1|NP_001159692.1	Q9UMR3	TBX20_HUMAN	T-box 20	3						nucleus	DNA binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(1)|lung(9)|prostate(1)|skin(1)|stomach(1)	18						GACGCCGTGAACTCCATGGTC	0.642000													15	13					0	0	0.001882	0	0
CD38	952	broad.mit.edu	37	4	15835868	15835868	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:15835868G>A	ENST00000226279.2	+	4	665	c.528G>A	c.(526-528)tgG>tgA	p.W176*		NM_001775.2	NP_001766.2	P28907	CD38_HUMAN	CD38 molecule	176					B cell receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of apoptosis|negative regulation of transcription, DNA-dependent|positive regulation of B cell proliferation|positive regulation of transcription, DNA-dependent|response to drug	integral to membrane|plasma membrane	binding|NAD+ nucleosidase activity|receptor activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(2)|prostate(1)|stomach(1)	14						GCCCAGACTGGAGAAAGGACT	0.408000													21	109					0	0	0.002780	0	0
CD74	972	broad.mit.edu	37	5	149784691	149784691	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:149784691T>C	ENST00000353334.6	-	5	673	c.494A>G	c.(493-495)aAc>aGc	p.N165S	CD74_ENST00000524315.1_Intron|CD74_ENST00000377795.3_Intron|CD74_ENST00000009530.7_Missense_Mutation_p.N165S	NM_001025159.2|NM_004355.3	NP_001020330.1|NP_004346.1	P04233	HG2A_HUMAN	CD74 molecule, major histocompatibility complex, class II invariant chain	165					antigen processing and presentation of endogenous antigen|cell proliferation|immunoglobulin mediated immune response|intracellular protein transport|negative regulation of apoptosis|negative regulation of DNA damage response, signal transduction by p53 class mediator|negative regulation of peptide secretion|positive regulation of B cell proliferation|positive regulation of chemokine (C-X-C motif) ligand 2 production|positive regulation of cytokine-mediated signaling pathway|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of macrophage cytokine production|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation|prostaglandin biosynthetic process|protein complex assembly|regulation of macrophage activation	endoplasmic reticulum membrane|Golgi apparatus|integral to membrane|lysosome|receptor complex	beta-amyloid binding|cytokine receptor activity|identical protein binding|MHC class II protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(1)	5		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GTGTCTCAGGTTCTCCGGGAA	0.567000			T	ROS1	NSCLC								61	106					0	0	0.003610	0	0
DOCK3	1795	broad.mit.edu	37	3	51395443	51395443	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:51395443G>A	ENST00000266037.9	+	46	4842	c.4819G>A	c.(4819-4821)Gaa>Aaa	p.E1607K		NM_004947.4	NP_004938.1	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1607	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(10)|kidney(4)|lung(22)|prostate(5)|urinary_tract(1)	45				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		TGTGCACCCAGAAATGCGGCC	0.507000													25	102					0	0	0.005443	0	0
AGPAT1	10554	broad.mit.edu	37	6	32138758	32138758	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32138758G>A	ENST00000395499.1	-	3	869	c.290C>T	c.(289-291)cCc>cTc	p.P97L	AGPAT1_ENST00000336984.6_Missense_Mutation_p.P97L|AGPAT1_ENST00000490711.1_Intron|AGPAT1_ENST00000375107.3_Missense_Mutation_p.P97L|AGPAT1_ENST00000375104.2_Missense_Mutation_p.P97L|AGPAT1_ENST00000395497.1_Missense_Mutation_p.P97L|AGPAT1_ENST00000395496.1_Missense_Mutation_p.P97L|AGPAT1_ENST00000412465.2_Intron|PPT2-EGFL8_ENST00000422437.1_3'UTR			Q99943	PLCA_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 1	97					energy reserve metabolic process|phosphatidic acid biosynthetic process|positive regulation of cellular metabolic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			central_nervous_system(1)|large_intestine(3)|lung(6)|ovary(2)	12						AACAACATAGGGCTGCGAGGG	0.592000													136	1172					0	0	0.003610	0	0
ATP8A2	51761	broad.mit.edu	37	13	26151272	26151272	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:26151272G>A	ENST00000381655.2	+	20	1920	c.1778G>A	c.(1777-1779)gGg>gAg	p.G593E	ATP8A2_ENST00000255283.8_Missense_Mutation_p.G553E|ATP8A2_ENST00000491840.1_3'UTR	NM_016529.4	NP_057613.4	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter, class I, type 8A, member 2	553					ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity	p.G593V(1)		breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(17)|lung(31)|ovary(4)|skin(3)|stomach(1)|urinary_tract(1)	72		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TACTGTAAAGGGGCTGTAAGT	0.443000													44	76					0	0	0.003610	0	0
KIF26B	55083	broad.mit.edu	37	1	245851531	245851531	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:245851531C>T	ENST00000366518.4	+	9	4207	c.4103C>T	c.(4102-4104)tCc>tTc	p.S1368F	KIF26B_ENST00000407071.2_Missense_Mutation_p.S1749F			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1749					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			CGCGGCCCGTCCGCCTCCACC	0.731000													4	26					0	0	0.001168	0	0
C5AR2	27202	broad.mit.edu	37	19	47844143	47844143	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:47844143G>A	ENST00000595464.1	+	2	305	c.87G>A	c.(85-87)ctG>ctA	p.L29L	C5AR2_ENST00000257267.2_Silent_p.L29L|C5AR2_ENST00000600626.1_Silent_p.L29L	NM_001271749.1	NP_001258678.1			complement component 5a receptor 2																		GCGCCTGCCTGGCCATCGACC	0.662000													24	38					0	0	0.002299	0	0
CYTH3	9265	broad.mit.edu	37	7	6210259	6210259	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:6210259T>A	ENST00000350796.3	-	9	866	c.730A>T	c.(730-732)Aag>Tag	p.K244*	CYTH3_ENST00000396741.2_Nonsense_Mutation_p.K159*|CYTH3_ENST00000488964.1_5'UTR	NM_004227.3	NP_004218.1	O43739	CYH3_HUMAN	cytohesin 3	244					regulation of ARF protein signal transduction|regulation of cell adhesion|vesicle-mediated transport	cytoplasm|membrane fraction|plasma membrane	1-phosphatidylinositol binding|ARF guanyl-nucleotide exchange factor activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|urinary_tract(1)	19						GGCTCGTTCTTAATGCTCTCA	0.582000													8	94					0	0	0.004482	0	0
TRPV4	59341	broad.mit.edu	37	12	110252389	110252389	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:110252389G>A	ENST00000418703.2	-	1	307	c.213C>T	c.(211-213)ttC>ttT	p.F71F	TRPV4_ENST00000346520.2_Silent_p.F71F|TRPV4_ENST00000261740.2_Silent_p.F71F|TRPV4_ENST00000537083.1_Silent_p.F71F|TRPV4_ENST00000536838.1_Silent_p.F37F|TRPV4_ENST00000392719.2_Silent_p.F71F|TRPV4_ENST00000541794.1_Silent_p.F71F|TRPV4_ENST00000544971.1_Silent_p.F71F	NM_001177431.1	NP_001170902.1	Q9HBA0	TRPV4_HUMAN	transient receptor potential cation channel, subfamily V, member 4	71					actin cytoskeleton reorganization|actin filament organization|calcium ion import|cell death|cell volume homeostasis|cell-cell junction assembly|cellular hypotonic response|cortical microtubule organization|elevation of cytosolic calcium ion concentration|microtubule polymerization|negative regulation of neuron projection development|osmosensory signaling pathway|positive regulation of microtubule depolymerization|response to mechanical stimulus	cortical actin cytoskeleton|filopodium|focal adhesion|growth cone|integral to membrane|lamellipodium|ruffle membrane	actin filament binding|alpha-tubulin binding|beta-tubulin binding|calcium channel activity|calmodulin binding|microtubule binding|protein binding|protein kinase C binding|SH2 domain binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(7)|ovary(3)|prostate(2)|skin(4)|stomach(1)	35						AGGCGCCCTGGAACTTCATGC	0.632000													9	28					0	0	0.006214	0	0
FAT1	2195	broad.mit.edu	37	4	187539895	187539895	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:187539895G>A	ENST00000441802.2	-	10	8054	c.7845C>T	c.(7843-7845)gtC>gtT	p.V2615V		NM_005245.3	NP_005236.2	Q14517	FAT1_HUMAN	FAT atypical cadherin 1	2615	Cadherin 24.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(38)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(33)|lung(88)|ovary(13)|pancreas(2)|prostate(16)|skin(2)|upper_aerodigestive_tract(11)|urinary_tract(4)	228						GAACTTTAACGACTGAAGTCC	0.428000										HNSCC(5;0.00058)			12	25					0	0	0.002450	0	0
SERTAD4	56256	broad.mit.edu	37	1	210415625	210415625	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:210415625A>T	ENST00000367012.3	+	4	1244	c.1014A>T	c.(1012-1014)aaA>aaT	p.K338N		NM_019605.3	NP_062551.1	Q9NUC0	SRTD4_HUMAN	SERTA domain containing 4	338							protein binding			endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(1)|urinary_tract(1)	14				OV - Ovarian serous cystadenocarcinoma(81;0.0237)|all cancers(67;0.127)		CCTTACGGAAAAAGGAGGCTT	0.388000													21	64					0	0	0.001882	0	0
TTN	7273	broad.mit.edu	37	2	179606494	179606494	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:179606494G>A	ENST00000589042.1	-	48	11690	c.11466C>T	c.(11464-11466)ttC>ttT	p.F3822F	TTN_ENST00000359218.5_Silent_p.F3584F|TTN-AS1_ENST00000590773.1_RNA|TTN_ENST00000342175.6_Silent_p.F3651F|TTN_ENST00000591111.1_Silent_p.F3505F|TTN_ENST00000460472.2_Silent_p.F3459F|TTN_ENST00000342992.6_Intron|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000582847.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	3505							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTCTTTGATGAAAATTGGGC	0.373000													20	17					0	0	0.001216	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328746	88328746	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:88328746C>T	ENST00000325089.6	+	2	1322	c.1103C>T	c.(1102-1104)tCc>tTc	p.S368F	SLITRK5_ENST00000400028.3_Missense_Mutation_p.S127F	NM_015567.1	NP_056382.1	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5	368	LRRNT.					integral to membrane				breast(1)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(14)|lung(40)|ovary(2)|pancreas(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(4)	81	all_neural(89;0.101)|Medulloblastoma(90;0.163)					CAGACCAAATCCCCGGTGCCT	0.597000													22	12					0	0	0.003330	0	0
OTX2	5015	broad.mit.edu	37	14	57270960	57270960	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:57270960G>A	ENST00000339475.5	-	4	495	c.219C>T	c.(217-219)atC>atT	p.I73I	OTX2_ENST00000554788.1_Intron|OTX2_ENST00000554559.1_Intron|OTX2_ENST00000408990.3_Silent_p.I65I|OTX2_ENST00000555006.1_Silent_p.I65I	NM_001270523.1|NM_001270524.1|NM_001270525.1|NM_021728.3	NP_001257452.1|NP_001257453.1|NP_001257454.1|NP_068374.1	P32243	OTX2_HUMAN	orthodenticle homeobox 2	65					axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	19	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					CTCGCATGAAGATGTCTGGGT	0.597000													11	20					0	0	0.001368	0	0
IARS2	55699	broad.mit.edu	37	1	220312443	220312443	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:220312443C>A	ENST00000366922.1	+	18	2384	c.2053C>A	c.(2053-2055)Cag>Aag	p.Q685K	IARS2_ENST00000302637.5_Missense_Mutation_p.Q757K			Q9NSE4	SYIM_HUMAN	isoleucyl-tRNA synthetase 2, mitochondrial	757					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			NS(1)|breast(1)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(17)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	TGTCATAGACCAGTACATGCT	0.348000													20	58					1.01871e-10	1.73384e-10	0.001216	1	0
FCHO1	23149	broad.mit.edu	37	19	17881307	17881307	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:17881307C>T	ENST00000594202.1	+	8	689	c.410C>T	c.(409-411)tCc>tTc	p.S137F	FCHO1_ENST00000252771.7_Missense_Mutation_p.S137F|FCHO1_ENST00000597512.1_Missense_Mutation_p.S144F|FCHO1_ENST00000600676.1_Missense_Mutation_p.S137F|FCHO1_ENST00000539407.1_Missense_Mutation_p.S137F|FCHO1_ENST00000596951.1_Missense_Mutation_p.S137F|FCHO1_ENST00000595033.1_Missense_Mutation_p.S87F|FCHO1_ENST00000596536.1_Missense_Mutation_p.S137F|FCHO1_ENST00000389133.4_Missense_Mutation_p.S137F	NM_001161357.1	NP_001154829.1	O14526	FCHO1_HUMAN	FCH domain only 1	137										NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						CTGCCCAAGTCCCGCGAGAAC	0.622000													13	20					0	0	0.001368	0	0
PMFBP1	83449	broad.mit.edu	37	16	72170368	72170368	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:72170368C>T	ENST00000537465.1	-	9	1340	c.1182G>A	c.(1180-1182)aaG>aaA	p.K394K	PMFBP1_ENST00000355636.6_Silent_p.K249K|PMFBP1_ENST00000237353.10_Silent_p.K394K			Q8TBY8	PMFBP_HUMAN	polyamine modulated factor 1 binding protein 1	394										NS(1)|breast(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(25)|ovary(2)|skin(3)|urinary_tract(1)	45		Ovarian(137;0.179)				TCAAAGTGAGCTTTTGGGTCT	0.547000													28	74					0	0	0.007291	0	0
ATP2A3	489	broad.mit.edu	37	17	3844779	3844779	+	Missense_Mutation	SNP	C	C	T	rs112116136	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:3844779C>T	ENST00000309890.7	-	13	1865	c.1715G>A	c.(1714-1716)aGg>aAg	p.R572K	ATP2A3_ENST00000397039.1_5'UTR|ATP2A3_ENST00000397041.3_Missense_Mutation_p.R572K|ATP2A3_ENST00000352011.3_Missense_Mutation_p.R572K|ATP2A3_ENST00000359983.3_Missense_Mutation_p.R572K|ATP2A3_ENST00000397035.3_Missense_Mutation_p.R572K|ATP2A3_ENST00000397043.3_Missense_Mutation_p.R572K	NM_174953.2|NM_174954.2|NM_174955.2|NM_174956.2	NP_777613.1|NP_777614.1|NP_777615.1|NP_777616.1	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous	572					ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(1)|skin(3)|stomach(1)|urinary_tract(1)	36				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		GTCCTCCTTCCTTGGGGGCGC	0.647000													26	30					0	0	0.005443	0	0
KIAA0319	9856	broad.mit.edu	37	6	24547559	24547559	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:24547559C>T	ENST00000535378.1	-	22	3668	c.3026G>A	c.(3025-3027)cGa>cAa	p.R1009Q	KIAA0319_ENST00000543707.1_Missense_Mutation_p.R1018Q|KIAA0319_ENST00000430948.2_Missense_Mutation_p.R973Q|KIAA0319_ENST00000378214.3_Missense_Mutation_p.R1018Q|KIAA0319_ENST00000537886.1_Missense_Mutation_p.R957Q	NM_001168374.1	NP_001161846.1	Q5VV43	K0319_HUMAN	KIAA0319	1018					negative regulation of dendrite development|neuron migration	early endosome membrane|integral to membrane|plasma membrane	protein binding			breast(3)|endometrium(6)|kidney(3)|large_intestine(11)|lung(19)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)	53						CTCTGTGCTTCGGTGCTTGAT	0.522000													13	24					0	0	0.001855	0	0
ARHGEF37	389337	broad.mit.edu	37	5	149001562	149001562	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:149001562C>T	ENST00000333677.6	+	9	1435	c.1272C>T	c.(1270-1272)ttC>ttT	p.F424F		NM_001001669.2	NP_001001669.2	A1IGU5	ARH37_HUMAN	Rho guanine nucleotide exchange factor (GEF) 37	424	BAR.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(5)|lung(6)|ovary(1)|prostate(2)|stomach(3)	17						TGTGCACATTCGTGACCCTCC	0.587000													15	19					0	0	0.002450	0	0
SMCR8	140775	broad.mit.edu	37	17	18220793	18220793	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:18220793C>T	ENST00000406438.3	+	1	2170	c.1690C>T	c.(1690-1692)Cca>Tca	p.P564S		NM_144775.2	NP_658988.2	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region, candidate 8	564										breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21						CATCAGTCCTCCAGAACTGGG	0.493000													37	64					0	0	0.005524	0	0
DNAH2	146754	broad.mit.edu	37	17	7673712	7673712	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:7673712C>T	ENST00000572933.1	+	25	5544	c.4084C>T	c.(4084-4086)Ctg>Ttg	p.L1362L	DNAH2_ENST00000389173.2_Silent_p.L1362L			Q9P225	DYH2_HUMAN	dynein, axonemal, heavy chain 2	1362	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(3)|breast(11)|central_nervous_system(1)|cervix(3)|endometrium(18)|haematopoietic_and_lymphoid_tissue(2)|kidney(16)|large_intestine(53)|liver(2)|lung(49)|ovary(7)|prostate(7)|skin(15)|upper_aerodigestive_tract(1)|urinary_tract(1)	189		all_cancers(10;4.66e-07)|Prostate(122;0.081)				AACTAAAGAGCTGGCTATAGA	0.537000													17	14					0	0	0.004007	0	0
GLIS3	169792	broad.mit.edu	37	9	3937169	3937169	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:3937169G>A	ENST00000324333.10	-	4	1459	c.1266C>T	c.(1264-1266)gcC>gcT	p.A422A	GLIS3_ENST00000461870.1_5'UTR|GLIS3_ENST00000381971.3_Silent_p.A577A	NM_152629.3	NP_689842.3	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3	422					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(12)|lung(4)|ovary(2)|prostate(1)|skin(1)	26		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		GCCTTGAAAAGGCCTTCTCGC	0.448000													26	61					0	0	0.005443	0	0
PEG3	5178	broad.mit.edu	37	19	57325597	57325597	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57325597C>T	ENST00000326441.9	-	10	4576	c.4213G>A	c.(4213-4215)Gaa>Aaa	p.E1405K	PEG3_ENST00000593695.1_Missense_Mutation_p.E1279K|PEG3_ENST00000423103.2_Missense_Mutation_p.E1405K|ZIM2_ENST00000599935.1_Intron|ZIM2_ENST00000593711.1_Intron|ZIM2_ENST00000601070.1_Intron|ZIM2_ENST00000391708.3_Intron|ZIM2_ENST00000221722.5_Intron|PEG3_ENST00000598410.1_Missense_Mutation_p.E1281K	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	1405	3 X 7 AA repeat of P-E-V-E-A-A-E.|Glu-rich.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GCCTCCACTTCTGGCTCGGCA	0.572000													25	60					0	0	0.005443	0	0
PLEKHH1	57475	broad.mit.edu	37	14	68044831	68044831	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:68044831T>C	ENST00000329153.5	+	19	2798	c.2666T>C	c.(2665-2667)gTt>gCt	p.V889A		NM_020715.2	NP_065766.1	Q9ULM0	PKHH1_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 1	889	MyTH4.					cytoskeleton	binding			endometrium(2)|kidney(4)|lung(12)|urinary_tract(1)	19				all cancers(60;0.000771)|OV - Ovarian serous cystadenocarcinoma(108;0.00502)|BRCA - Breast invasive adenocarcinoma(234;0.011)		GTCTGCCTGGTTCACCCCGAG	0.617000													22	35					0	0	0.002299	0	0
RPL8	6132	broad.mit.edu	37	8	146016825	146016825	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:146016825G>A	ENST00000262584.3	-	4	568	c.336C>T	c.(334-336)atC>atT	p.I112I	RPL8_ENST00000394920.2_Silent_p.I112I|RPL8_ENST00000528957.1_Silent_p.I112I|RPL8_ENST00000529163.1_5'UTR|RPL8_ENST00000527914.1_Intron	NM_000973.3	NP_000964.1	P62917	RL8_HUMAN	ribosomal protein L8	112					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	rRNA binding|structural constituent of ribosome			kidney(12)|lung(7)|prostate(1)	20	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;5.47e-39)|OV - Ovarian serous cystadenocarcinoma(54;6.38e-39)|all cancers(56;5.47e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;0.191)		GGCAGCACACGATTGTACCCT	0.577000													10	73					0	0	0.006214	0	0
MFN1	55669	broad.mit.edu	37	3	179095136	179095136	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:179095136C>T	ENST00000471841.1	+	12	1355	c.1229C>T	c.(1228-1230)tCa>tTa	p.S410L	MFN1_ENST00000263969.5_Missense_Mutation_p.S410L|MFN1_ENST00000280653.7_Missense_Mutation_p.S410L	NM_033540.2	NP_284941.2	Q8IWA4	MFN1_HUMAN	mitofusin 1	410					mitochondrial fusion	integral to membrane|mitochondrial outer membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(14)|ovary(3)|prostate(1)|urinary_tract(1)	31	all_cancers(143;1.67e-16)|Ovarian(172;0.0172)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.00225)|BRCA - Breast invasive adenocarcinoma(182;0.0923)			TTTCAGGTTTCATGTGCAATG	0.239000													28	86					0	0	0.002096	0	0
PTK2	5747	broad.mit.edu	37	8	141874443	141874443	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:141874443C>T	ENST00000522684.1	-	5	647	c.418G>A	c.(418-420)Gat>Aat	p.D140N	PTK2_ENST00000340930.3_Missense_Mutation_p.D140N|PTK2_ENST00000535192.1_Missense_Mutation_p.D140N|PTK2_ENST00000521059.1_Missense_Mutation_p.D140N|PTK2_ENST00000517887.1_Missense_Mutation_p.D184N|PTK2_ENST00000519419.1_Missense_Mutation_p.D184N|PTK2_ENST00000395218.2_Missense_Mutation_p.D140N	NM_153831.3	NP_722560.1	Q05397	FAK1_HUMAN	protein tyrosine kinase 2	140	FERM.				axon guidance|blood coagulation|cellular component disassembly involved in apoptosis|ephrin receptor signaling pathway|growth hormone receptor signaling pathway|integrin-mediated signaling pathway|peptidyl-tyrosine phosphorylation|protein autophosphorylation|regulation of cell adhesion mediated by integrin|signal complex assembly	cytoskeleton|cytosol|focal adhesion	ATP binding|JUN kinase binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|signal transducer activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(2)|large_intestine(6)|lung(23)|ovary(2)|prostate(1)|skin(3)|urinary_tract(1)	48	all_cancers(97;1.05e-15)|all_epithelial(106;2.09e-14)|Lung NSC(106;1.61e-06)|all_lung(105;2.5e-06)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;2.72e-05)|Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.137)			GTTGGCTTATCTTCAGTAAAC	0.264000													38	132					0	0	0.002222	0	0
PHKA1	5255	broad.mit.edu	37	X	71802346	71802346	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:71802346G>A	ENST00000373545.3	-	31	3712	c.3274C>T	c.(3274-3276)Ctc>Ttc	p.L1092F	PHKA1_ENST00000541944.1_Missense_Mutation_p.L1062F|PHKA1_ENST00000339490.3_Missense_Mutation_p.L1121F|PHKA1_ENST00000373539.3_Missense_Mutation_p.L1151F|PHKA1_ENST00000373542.4_Missense_Mutation_p.L1134F			P46020	KPB1_HUMAN	phosphorylase kinase, alpha 1 (muscle)	1134					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(9)|liver(2)|lung(18)|ovary(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	52	Renal(35;0.156)					AGCATGGTGAGGACAAGGATG	0.453000													20	3					0	0	0.001216	0	0
NRXN1	9378	broad.mit.edu	37	2	50464101	50464101	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:50464101C>T	ENST00000404971.1	-	19	4831	c.3492G>A	c.(3490-3492)acG>acA	p.T1164T	NRXN1_ENST00000342183.5_Silent_p.T89T|NRXN1_ENST00000402717.3_Silent_p.T1116T|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000406859.3_Silent_p.T1124T|NRXN1_ENST00000401669.2_Silent_p.T1124T|NRXN1_ENST00000401710.1_Silent_p.T142T|NRXN1_ENST00000405472.3_Silent_p.T1116T|NRXN1_ENST00000406316.2_Silent_p.T1124T	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	1124	Laminin G-like 6.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AGATATATGTCGTCCCAGCTG	0.408000													19	47					0	0	0.002299	0	0
RECK	8434	broad.mit.edu	37	9	36122903	36122903	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:36122903T>A	ENST00000377966.3	+	21	3343	c.2777T>A	c.(2776-2778)cTc>cAc	p.L926H		NM_021111.2	NP_066934.1	O95980	RECK_HUMAN	reversion-inducing-cysteine-rich protein with kazal motifs	926						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(7)|kidney(3)|large_intestine(6)|lung(10)|ovary(1)|pancreas(1)|skin(2)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			CATGTCCCTCTCTCTGCCCTC	0.557000													32	110					0	0	0.004878	0	0
FAM65A	79567	broad.mit.edu	37	16	67578895	67578895	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:67578895C>T	ENST00000540839.3	+	18	3183	c.2963C>T	c.(2962-2964)aCc>aTc	p.T988I	FAM65A_ENST00000428437.2_Missense_Mutation_p.T983I|FAM65A_ENST00000042381.4_Missense_Mutation_p.T969I|FAM65A_ENST00000422602.2_Missense_Mutation_p.T989I|FAM65A_ENST00000379312.3_Missense_Mutation_p.T973I			Q6ZS17	FA65A_HUMAN	family with sequence similarity 65, member A	973						cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		GGCTTCCTGACCTTCTGGGAC	0.617000													45	136					0	0	0.002852	0	0
PEX26	55670	broad.mit.edu	37	22	18568002	18568002	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:18568002C>T	ENST00000329627.6	+	5	998	c.792C>T	c.(790-792)ctC>ctT	p.L264L	PEX26_ENST00000428061.2_Intron|PEX26_ENST00000399744.3_Silent_p.L264L	NM_017929.5	NP_060399.1	Q7Z412	PEX26_HUMAN	peroxisomal biogenesis factor 26	264					protein import into peroxisome matrix|protein import into peroxisome membrane	integral to peroxisomal membrane	protein C-terminus binding|protein complex binding			breast(1)|kidney(2)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	13						TCCTCTGTCTCCTGGTGGTGA	0.562000													38	128					0	0	0.006999	0	0
SMYD4	114826	broad.mit.edu	37	17	1690790	1690790	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:1690790G>A	ENST00000305513.7	-	6	1813	c.1646C>T	c.(1645-1647)tCc>tTc	p.S549F		NM_052928.2	NP_443160.2	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	549	SET.						zinc ion binding			breast(4)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)|skin(5)|stomach(1)	21						GCTAATGAAGGACACGCTGGT	0.587000													4	3					0	0	0.000248	0	0
DSG4	147409	broad.mit.edu	37	18	28992958	28992958	+	Silent	SNP	G	G	A	rs151048983		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:28992958G>A	ENST00000359747.4	+	15	2609	c.2580G>A	c.(2578-2580)agG>agA	p.R860R	DSG4_ENST00000308128.4_Silent_p.R841R|RP11-534N16.1_ENST00000578477.1_RNA|RP11-534N16.1_ENST00000581856.1_RNA	NM_001134453.1	NP_001127925.1	Q86SJ6	DSG4_HUMAN	desmoglein 4	841					homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			NS(1)|breast(1)|central_nervous_system(6)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(11)|liver(2)|lung(35)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CAAAATTTAGGACTCTTGCTG	0.443000													30	34					0	0	0.001512	0	0
HMCN1	83872	broad.mit.edu	37	1	186088384	186088384	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:186088384G>A	ENST00000271588.4	+	78	12139	c.11910G>A	c.(11908-11910)agG>agA	p.R3970R	HMCN1_ENST00000367492.2_Silent_p.R3970R	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	3970	Ig-like C2-type 38.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						GTGTCGCTAGGAATGCGGCTG	0.403000													35	165					0	0	0.002522	0	0
FOXP4	116113	broad.mit.edu	37	6	41558050	41558050	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:41558050C>T	ENST00000373060.1	+	12	1857	c.1399C>T	c.(1399-1401)Cgg>Tgg	p.R467W	FOXP4_ENST00000409208.1_Missense_Mutation_p.R455W|FOXP4_ENST00000373063.3_Missense_Mutation_p.R454W|FOXP4_ENST00000373057.3_Missense_Mutation_p.R465W|FOXP4_ENST00000307972.4_Missense_Mutation_p.R467W	NM_001012426.1|NM_001012427.1	NP_001012426.1|NP_001012427.1	Q8IVH2	FOXP4_HUMAN	forkhead box P4	467					embryonic foregut morphogenesis|heart development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	16	Ovarian(28;0.0327)|Colorectal(47;0.196)					CGCCGACGTCCGGCCCCCCTT	0.632000													22	158					0	0	0.002780	0	0
TCEB3C	162699	broad.mit.edu	37	18	44555073	44555073	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:44555073C>T	ENST00000330682.2	-	1	1376	c.1141G>A	c.(1141-1143)Gac>Aac	p.D381N	KATNAL2_ENST00000592005.1_Intron|KATNAL2_ENST00000245121.5_Intron|KATNAL2_ENST00000356157.7_Intron	NM_145653.3	NP_663628.2	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide 3C (elongin A3)	381	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding			NS(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(16)|skin(2)	30						GCGGCATTGTCTTTCTCTGTG	0.572000													27	1348					0	0	0.001523	0	0
MACF1	23499	broad.mit.edu	37	1	39782178	39782178	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:39782178G>A	ENST00000564288.1	+	28	4342	c.3565G>A	c.(3565-3567)Gag>Aag	p.E1189K	MACF1_ENST00000361689.2_Missense_Mutation_p.E1194K|MACF1_ENST00000476350.1_3'UTR|MACF1_ENST00000539005.1_Missense_Mutation_p.E1194K|MACF1_ENST00000545844.1_Missense_Mutation_p.E1194K|MACF1_ENST00000567887.1_Missense_Mutation_p.E1226K|MACF1_ENST00000372915.3_Missense_Mutation_p.E1194K|MACF1_ENST00000317713.7_Missense_Mutation_p.E1194K			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	1194					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTCAGCTCTGGAGGCCCATTG	0.433000													47	79					0	0	0.003610	0	0
KLC4	89953	broad.mit.edu	37	6	43034148	43034148	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43034148C>T	ENST00000394056.2	+	6	1171	c.676C>T	c.(676-678)Cgc>Tgc	p.R226C	KLC4_ENST00000479388.1_Missense_Mutation_p.R226C|KLC4_ENST00000453940.2_Missense_Mutation_p.R149C|KLC4_ENST00000347162.5_Missense_Mutation_p.R226C|KLC4_ENST00000458460.2_Missense_Mutation_p.R226C|KLC4_ENST00000394058.1_Missense_Mutation_p.R226C|KLC4_ENST00000259708.3_Missense_Mutation_p.R244C			Q9NSK0	KLC4_HUMAN	kinesin light chain 4	226						cytoplasm|kinesin complex|microtubule	microtubule motor activity|protein binding			endometrium(2)|large_intestine(7)|lung(5)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(4)	23			all cancers(41;0.00169)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0376)|KIRC - Kidney renal clear cell carcinoma(2;0.0453)			AGCCCAAGGTCGCTATGAGGT	0.597000													22	98					0	0	0.002780	0	0
UBR4	23352	broad.mit.edu	37	1	19403252	19403252	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:19403252C>T	ENST00000375267.2	-	106	15535	c.15532G>A	c.(15532-15534)Gag>Aag	p.E5178K	UBR4_ENST00000429347.2_Missense_Mutation_p.E680K|UBR4_ENST00000375217.2_Missense_Mutation_p.E5150K|UBR4_ENST00000375254.3_Missense_Mutation_p.E5157K|UBR4_ENST00000375224.1_Missense_Mutation_p.E864K|UBR4_ENST00000375226.2_Missense_Mutation_p.E5133K|UBR4_ENST00000375225.3_Missense_Mutation_p.E232K|UBR4_ENST00000543981.1_Missense_Mutation_p.E821K			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	5157					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TCGAGGAACTCTGAGAAGGTC	0.527000													73	148					0	0	0.003610	0	0
PEG3	5178	broad.mit.edu	37	19	57335673	57335673	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57335673G>A	ENST00000326441.9	-	4	714	c.351C>T	c.(349-351)ctC>ctT	p.L117L	PEG3_ENST00000594706.1_5'UTR|ZIM2_ENST00000593931.1_5'UTR|PEG3_ENST00000593695.1_5'UTR|PEG3_ENST00000423103.2_Silent_p.L117L|ZIM2_ENST00000599935.1_5'UTR|ZIM2_ENST00000593711.1_5'UTR|ZIM2_ENST00000601070.1_5'UTR|ZIM2_ENST00000391708.3_5'UTR|ZIM2_ENST00000221722.5_5'UTR|PEG3_ENST00000598410.1_5'UTR	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	117	SCAN box.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GCAGAGTGACGAGCTTCTCAC	0.547000													36	68					0	0	0.005524	0	0
ZNF468	90333	broad.mit.edu	37	19	53344355	53344355	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:53344355G>A	ENST00000595646.1	-	4	1312	c.1192C>T	c.(1192-1194)Ctt>Ttt	p.L398F	ZNF468_ENST00000390651.4_Missense_Mutation_p.L345F|ZNF468_ENST00000243639.4_3'UTR|ZNF468_ENST00000396409.4_Missense_Mutation_p.L345F|ZNF28_ENST00000594602.1_Intron			Q5VIY5	ZN468_HUMAN	zinc finger protein 468	398					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(5)|ovary(2)|skin(1)|stomach(3)|urinary_tract(1)	23				GBM - Glioblastoma multiforme(134;0.0358)		TGTCTTTCAAGGTGTGATTTG	0.403000													22	114					0	0	0.002780	0	0
TPRN	286262	broad.mit.edu	37	9	140093725	140093725	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:140093725C>T	ENST00000409012.4	-	1	1525	c.1439G>A	c.(1438-1440)aGg>aAg	p.R480K	TPRN_ENST00000541945.1_Intron|TPRN_ENST00000321773.2_Missense_Mutation_p.R419K	NM_001128228.2	NP_001121700.2	Q4KMQ1	TPRN_HUMAN	taperin	480					sensory perception of sound	stereocilium				breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)	8						GTGCAGAGGCCTGGCAGGGTG	0.652000													19	29					0	0	0.001523	0	0
CPNE9	151835	broad.mit.edu	37	3	9771272	9771272	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:9771272G>A	ENST00000383832.3	+	21	1748	c.1558G>A	c.(1558-1560)Gag>Aag	p.E520K		NM_153635.2	NP_705899.2	Q8IYJ1	CPNE9_HUMAN	copine family member IX	520										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	16	Medulloblastoma(99;0.227)					TGTGCTGGCCGAGATCCCGGA	0.637000													23	42					0	0	0.003954	0	0
ZZEF1	23140	broad.mit.edu	37	17	3937385	3937385	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:3937385C>T	ENST00000381638.2	-	40	6632	c.6508G>A	c.(6508-6510)Ggg>Agg	p.G2170R		NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	2170							calcium ion binding|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						GAACTGTCCCCTGCAGCAAAC	0.547000													40	65					0	0	0.003610	0	0
COL1A1	1277	broad.mit.edu	37	17	48268227	48268227	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:48268227A>G	ENST00000225964.5	-	33	2412	c.2294T>C	c.(2293-2295)cTg>cCg	p.L765P		NM_000088.3	NP_000079.2	P02452	CO1A1_HUMAN	collagen, type I, alpha 1	765	Triple-helical region.				axon guidance|blood vessel development|collagen biosynthetic process|collagen fibril organization|embryonic skeletal system development|leukocyte migration|platelet activation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|protein localization to nucleus|sensory perception of sound|skin morphogenesis|tooth mineralization|visual perception	collagen type I|extracellular space|plasma membrane	identical protein binding|platelet-derived growth factor binding		COL1A1/PDGFB(429)	NS(1)|breast(3)|central_nervous_system(8)|endometrium(3)|kidney(4)|large_intestine(17)|liver(3)|lung(18)|ovary(1)|pancreas(1)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	71					Collagenase(DB00048)|Palifermin(DB00039)	GGGGCCAGTCAGACCACGGAC	0.592000			T	"""PDGFB, USP6"""	"""dermatofibrosarcoma protuberans, aneurysmal bone cyst """		Osteogenesis imperfecta						31	12					0	0	0.003755	0	0
DEFB115	245929	broad.mit.edu	37	20	29845498	29845498	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:29845498G>A	ENST00000400552.1	+	1	32	c.32G>A	c.(31-33)gGa>gAa	p.G11E		NM_001037730.1	NP_001032819.1	Q30KQ5	DB115_HUMAN	defensin, beta 115	11					defense response to bacterium	extracellular region				kidney(1)|lung(3)|ovary(1)|skin(1)	6			Colorectal(19;0.00445)|COAD - Colon adenocarcinoma(19;0.0347)			CCCCTCTCAGGAGACATTAAA	0.512000													20	57					0	0	0.001523	0	0
ARAP2	116984	broad.mit.edu	37	4	36163142	36163142	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:36163142G>A	ENST00000303965.4	-	12	2693	c.2204C>T	c.(2203-2205)tCc>tTc	p.S735F		NM_015230.3	NP_056045.2	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	735	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(32)|ovary(2)|pancreas(1)|prostate(3)|skin(7)|urinary_tract(1)	82						TCTAACCTTGGAATCTTTTGG	0.348000													22	98					0	0	0.003330	0	0
PRKAR1B	5575	broad.mit.edu	37	7	751017	751017	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:751017C>T	ENST00000406797.1	-	2	300	c.126G>A	c.(124-126)aaG>aaA	p.K42K	PRKAR1B_ENST00000488474.1_5'UTR|PRKAR1B_ENST00000403562.1_Silent_p.K42K|PRKAR1B_ENST00000360274.4_Silent_p.K42K|PRKAR1B_ENST00000544935.1_Silent_p.K42K|PRKAR1B_ENST00000537384.1_Silent_p.K42K	NM_001164761.1	NP_001158233.1	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, beta	42	Dimerization and phosphorylation.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity			endometrium(4)|large_intestine(1)|liver(1)|lung(10)|prostate(1)	17		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		GGCGTTCGGGCTTGGAGATGC	0.637000													10	109					0	0	0.006214	0	0
LARGE	9215	broad.mit.edu	37	22	33673211	33673211	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:33673211G>A	ENST00000354992.2	-	15	2479	c.1908C>T	c.(1906-1908)ccC>ccT	p.P636P	LARGE_ENST00000402320.1_Silent_p.P584P|LARGE_ENST00000452586.2_Silent_p.P435P|LARGE_ENST00000437602.2_Silent_p.P587P|LARGE_ENST00000337431.2_Silent_p.P584P|LARGE_ENST00000397394.2_Silent_p.P636P	NM_004737.4	NP_004728.1	O95461	LARGE_HUMAN	like-glycosyltransferase	636					glycosphingolipid biosynthetic process|muscle cell homeostasis|N-acetylglucosamine metabolic process|protein glycosylation	integral to Golgi membrane	acetylglucosaminyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|lung(23)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	51		Lung NSC(1;0.219)				CGAAGTTTGTGGGTGCGTGGC	0.582000													9	75					0	0	0.006214	0	0
SCAND3	114821	broad.mit.edu	37	6	28541011	28541011	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:28541011C>T	ENST00000452236.2	-	4	3272	c.2655G>A	c.(2653-2655)atG>atA	p.M885I		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	885					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						gttgatcttccatatcattag	0.373000													38	175					0	0	0.001951	0	0
LRRC8D	55144	broad.mit.edu	37	1	90398924	90398924	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:90398924C>T	ENST00000337338.5	+	3	704	c.297C>T	c.(295-297)tcC>tcT	p.S99S	LRRC8D_ENST00000394593.3_Silent_p.S99S	NM_001134479.1	NP_001127951.1	Q7L1W4	LRC8D_HUMAN	leucine rich repeat containing 8 family, member D	99						integral to membrane	protein binding			breast(2)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(10)|ovary(2)|skin(1)	29		all_lung(203;0.0894)|Lung NSC(277;0.227)		all cancers(265;0.0109)|Epithelial(280;0.0427)		ACGACATTTCCTTTGGGACAT	0.498000													13	12					0	0	0.001368	0	0
FBN1	2200	broad.mit.edu	37	15	48748863	48748863	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:48748863A>C	ENST00000316623.5	-	44	5848	c.5393T>G	c.(5392-5394)tTc>tGc	p.F1798C		NM_000138.4	NP_000129.3	P35555	FBN1_HUMAN	fibrillin 1	1798	EGF-like 29; calcium-binding.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			NS(1)|breast(5)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|liver(1)|lung(49)|ovary(4)|pancreas(1)|prostate(9)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	139		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GTCATTATAGAAGAATCCCAC	0.438000													30	51					0	0	0.001786	0	0
SCAND3	114821	broad.mit.edu	37	6	28540061	28540061	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:28540061C>T	ENST00000452236.2	-	4	4222	c.3605G>A	c.(3604-3606)gGa>gAa	p.G1202E		NM_052923.1	NP_443155.1	Q6R2W3	SCND3_HUMAN	SCAN domain containing 3	1202					DNA integration|viral reproduction	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			NS(3)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(14)|liver(1)|lung(29)|ovary(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(3)	71						ccacaaatttcctatgcgtgg	0.328000													6	40					0	0	0.001168	0	0
SLC12A5	57468	broad.mit.edu	37	20	44676132	44676132	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:44676132C>T	ENST00000454036.1	+	15	1972	c.1896C>T	c.(1894-1896)ctC>ctT	p.L632L	SLC12A5_ENST00000243964.3_Silent_p.L609L|SLC12A5_ENST00000539566.1_3'UTR	NM_001134771.1	NP_001128243.1	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 5	632					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|liver(1)|lung(38)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	80		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	GCCTGGCCCTCATGTTCATCT	0.577000													48	98					0	0	0.003610	0	0
TAS1R1	80835	broad.mit.edu	37	1	6631072	6631072	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:6631072G>A	ENST00000333172.6	+	2	488	c.295G>A	c.(295-297)Ggg>Agg	p.G99R	TAS1R1_ENST00000351136.3_Missense_Mutation_p.G99R|TAS1R1_ENST00000328191.4_Missense_Mutation_p.G99R	NM_138697.3	NP_619642.2	Q7RTX1	TS1R1_HUMAN	taste receptor, type 1, member 1	99					sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(13)|ovary(1)|skin(1)|urinary_tract(2)	29	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		CATCACCCTGGGGTACCAGCT	0.547000													55	113					0	0	0.003610	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73185051	73185051	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:73185051G>A	ENST00000286657.4	-	9	1386	c.1350C>T	c.(1348-1350)atC>atT	p.I450I		NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	450	Peptidase M12B.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GGACATACTGGATATATCTTT	0.423000													23	23					0	0	0.004656	0	0
REV3L	5980	broad.mit.edu	37	6	111632369	111632369	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:111632369C>T	ENST00000435970.1	-	31	9280	c.8464G>A	c.(8464-8466)Gga>Aga	p.G2822R	REV3L_ENST00000368802.3_Missense_Mutation_p.G2900R|REV3L_ENST00000462119.1_5'UTR|REV3L_ENST00000368805.1_Missense_Mutation_p.G2900R|RP5-1112D6.8_ENST00000607434.1_RNA|REV3L_ENST00000358835.3_Missense_Mutation_p.G2900R			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	2900					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		CTGGCCTTTCCTTCCAGAAGC	0.383000								DNA polymerases (catalytic subunits)					49	124					0	0	0.003610	0	0
C7orf50	84310	broad.mit.edu	37	7	1037314	1037314	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:1037314G>A	ENST00000397098.3	-	5	1458	c.532C>T	c.(532-534)Ccc>Tcc	p.P178S	C7orf50_ENST00000488073.1_5'UTR|C7orf50_ENST00000357429.6_Missense_Mutation_p.P178S|C7orf50_ENST00000397100.2_Missense_Mutation_p.P178S			Q9BRJ6	CG050_HUMAN	chromosome 7 open reading frame 50	178							protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)	6		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)		CCCGGCAGGGGGGGATCAGAG	0.721000													33	34					0	0	0.002836	0	0
LHX1	3975	broad.mit.edu	37	17	35300134	35300134	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:35300134G>A	ENST00000254457.5	+	5	2338	c.927G>A	c.(925-927)gtG>gtA	p.V309V	RP11-445F12.2_ENST00000607336.1_RNA	NM_005568.3	NP_005559.2	P48742	LHX1_HUMAN	LIM homeobox 1	309					cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(1)	16		Breast(25;0.00607)				AGACACCAGTGGACCTACCCT	0.716000													6	1					0	0	0.001168	0	0
OSR1	130497	broad.mit.edu	37	2	19553163	19553163	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:19553163C>T	ENST00000536433.1	-	1	3514	c.404G>A	c.(403-405)gGt>gAt	p.G135D	OSR1_ENST00000272223.2_Missense_Mutation_p.G135D			Q8TAX0	OSR1_HUMAN	odd-skipped related transciption factor 1	135					chondrocyte differentiation|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic hindlimb morphogenesis|embryonic leg joint morphogenesis|embryonic skeletal joint morphogenesis|heart development|mesangial cell development|mesonephric duct morphogenesis|metanephric cap mesenchymal cell proliferation involved in metanephros development|metanephric glomerulus vasculature development|metanephric interstitial cell development|metanephric mesenchymal cell differentiation|metanephric nephron tubule development|metanephric smooth muscle tissue development|middle ear morphogenesis|negative regulation of apoptosis|negative regulation of nephron tubule epithelial cell differentiation|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|palate development|pattern specification involved in metanephros development|positive regulation of bone mineralization|positive regulation of epithelial cell proliferation|positive regulation of gastrulation|positive regulation of transcription from RNA polymerase II promoter|pronephros development|renal vesicle progenitor cell differentiation|specification of anterior mesonephric tubule identity|specification of posterior mesonephric tubule identity|stem cell differentiation|transcription, DNA-dependent|ureter urothelium development|ureteric bud development	nucleolus	nucleic acid binding|zinc ion binding			breast(1)|large_intestine(2)|lung(4)|ovary(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	Acute lymphoblastic leukemia(84;0.221)				CTCCCCGCGACCGAGCTTGGC	0.637000													25	65					0	0	0.004656	0	0
CACNA2D4	93589	broad.mit.edu	37	12	1904487	1904487	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:1904487G>A	ENST00000382722.5	-	37	3649	c.3287C>T	c.(3286-3288)tCc>tTc	p.S1096F	CACNA2D4_ENST00000586184.1_Missense_Mutation_p.S1096F|CACNA2D4_ENST00000538450.1_Missense_Mutation_p.S226F|CACNA2D4_ENST00000538027.2_Missense_Mutation_p.S241F|CACNA2D4_ENST00000587995.1_Missense_Mutation_p.S1071F|CACNA2D4_ENST00000585708.1_Missense_Mutation_p.S1032F|CACNA2D4_ENST00000588077.1_Missense_Mutation_p.S1032F	NM_172364.4	NP_758952.4	Q7Z3S7	CA2D4_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 4	1096						integral to membrane	calcium channel activity|metal ion binding|voltage-gated ion channel activity			endometrium(3)|kidney(2)|large_intestine(1)|liver(1)|lung(27)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	39	Ovarian(42;0.107)	Myeloproliferative disorder(1001;0.206)	OV - Ovarian serous cystadenocarcinoma(31;0.00113)	Kidney(2;0.0205)|KIRC - Kidney renal clear cell carcinoma(2;0.0451)		GGCGTGGCAGGAGTCTGGTCG	0.592000													10	21					0	0	0.001368	0	0
CTD-2587H24.4	0	broad.mit.edu	37	19	55670969	55670969	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55670969G>A	ENST00000587871.1	-	3	153	c.154C>T	c.(154-156)Cca>Tca	p.P52S	DNAAF3_ENST00000391720.4_Silent_p.V437V|DNAAF3_ENST00000455045.1_Silent_p.V336V|DNAAF3_ENST00000527223.2_Silent_p.V457V|DNAAF3_ENST00000524407.2_Silent_p.V390V|DNAAF3_ENST00000587789.2_5'UTR|CTD-2587H24.5_ENST00000591665.1_RNA																							TGAGAAGATGGACCATACTGC	0.597000													25	65					0	0	0.003330	0	0
CRTC2	200186	broad.mit.edu	37	1	153923985	153923985	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:153923985G>A	ENST00000368633.1	-	11	1282	c.1155C>T	c.(1153-1155)acC>acT	p.T385T	CRTC2_ENST00000368630.3_Silent_p.T65T	NM_181715.2	NP_859066.1	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	385	Ser-rich.				interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			NS(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(5)|lung(8)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)	27	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GGCCCAGGGAGGTGGTGGGCA	0.647000													13	38					0	0	0.004990	0	0
ALG3	10195	broad.mit.edu	37	3	183961677	183961677	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:183961677G>A	ENST00000455059.1	-	6	1168	c.714C>T	c.(712-714)ttC>ttT	p.F238F	ALG3_ENST00000418734.2_Silent_p.F222F|EIF2B5_ENST00000444495.1_Intron|ALG3_ENST00000463495.1_5'UTR|ALG3_ENST00000397676.3_Silent_p.F278F|ALG3_ENST00000445626.2_Silent_p.F230F			Q92685	ALG3_HUMAN	ALG3, alpha-1,3- mannosyltransferase	278					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity			kidney(1)|large_intestine(1)|lung(6)|upper_aerodigestive_tract(1)	9	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCTCTGGGAGGAAGCGCCAGT	0.632000													15	25					0	0	0.003163	0	0
TRAP1	10131	broad.mit.edu	37	16	3722817	3722817	+	Missense_Mutation	SNP	G	G	A	rs111548439		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:3722817G>A	ENST00000575671.1	-	5	1151	c.422C>T	c.(421-423)cCg>cTg	p.P141L	TRAP1_ENST00000573872.1_Intron|TRAP1_ENST00000538171.1_Missense_Mutation_p.P297L|TRAP1_ENST00000246957.5_Missense_Mutation_p.P350L			Q12931	TRAP1_HUMAN	TNF receptor-associated protein 1	350					cellular response to oxidative stress|protein folding	mitochondrion	ATP binding|tumor necrosis factor receptor binding|unfolded protein binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(3)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	19		Ovarian(90;0.0261)				AAACATGGACGGTTTCTGGGG	0.627000													3	9					0	0	0.004672	0	0
KCNK17	89822	broad.mit.edu	37	6	39271779	39271779	+	Silent	SNP	G	G	A	rs140940240	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:39271779G>A	ENST00000453413.2	-	4	782	c.642C>T	c.(640-642)ttC>ttT	p.F214F	KCNK17_ENST00000373231.4_Silent_p.F214F	NM_001135111.1	NP_001128583.1	Q96T54	KCNKH_HUMAN	potassium channel, subfamily K, member 17	214						integral to membrane	potassium channel activity|voltage-gated ion channel activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(2)	14						TGATGAAGGCGAAGTAGAAGC	0.632000													26	111					0	0	0.007291	0	0
SEMA3F	6405	broad.mit.edu	37	3	50219719	50219719	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:50219719G>A	ENST00000002829.3	+	8	1130	c.646G>A	c.(646-648)Gag>Aag	p.E216K	SEMA3F_ENST00000413852.1_Missense_Mutation_p.E117K|SEMA3F_ENST00000434342.1_Missense_Mutation_p.E185K	NM_004186.3	NP_004177.3	Q13275	SEM3F_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	216	Sema.				axon guidance	extracellular space|membrane	chemorepellent activity|receptor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(1)|skin(2)	17				BRCA - Breast invasive adenocarcinoma(193;0.00013)|KIRC - Kidney renal clear cell carcinoma(197;0.00599)|Kidney(197;0.00688)		ACCCACAGATGAGGAGCTCTA	0.567000													23	46					0	0	0.001882	0	0
SURF6	6838	broad.mit.edu	37	9	136199576	136199576	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:136199576G>A	ENST00000372022.4	-	4	679	c.414C>T	c.(412-414)tcC>tcT	p.S138S	SURF6_ENST00000468290.1_5'UTR	NM_006753.4	NP_006744.2	O75683	SURF6_HUMAN	surfeit 6	138						granular component	DNA binding|RNA binding			endometrium(1)|large_intestine(5)|lung(5)|ovary(1)	12				OV - Ovarian serous cystadenocarcinoma(145;1.16e-06)|Epithelial(140;8.34e-06)|all cancers(34;7.08e-05)		AGGCGGCAGGGGACAGCTCCT	0.602000													23	31					0	0	0.002780	0	0
IFIH1	64135	broad.mit.edu	37	2	163134116	163134116	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:163134116C>T	ENST00000263642.2	-	10	2248	c.1853G>A	c.(1852-1854)cGa>cAa	p.R618Q		NM_022168.3	NP_071451.2	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	618					detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(14)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	39						ATCTATCATTCGAATTGTGTC	0.358000													49	33					0	0	0.003610	0	0
KLHL24	54800	broad.mit.edu	37	3	183368598	183368598	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:183368598C>T	ENST00000454652.1	+	4	840	c.454C>T	c.(454-456)Cgt>Tgt	p.R152C	KLHL24_ENST00000242810.6_Missense_Mutation_p.R152C|KLHL24_ENST00000476808.1_Missense_Mutation_p.R152C			Q6TFL4	KLH24_HUMAN	kelch-like family member 24	152						axon|cytoplasm|perikaryon				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			TAGTGTTCTCCGTGATGCATG	0.408000													29	84					0	0	0.006320	0	0
PCDHB12	56124	broad.mit.edu	37	5	140589305	140589305	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140589305G>A	ENST00000239450.2	+	1	1015	c.826G>A	c.(826-828)Gaa>Aaa	p.E276K	PCDHB12_ENST00000541609.1_Intron	NM_018932.3	NP_061755.1	Q9Y5F1	PCDBC_HUMAN		276	Cadherin 3.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(3)|endometrium(10)|large_intestine(17)|lung(38)|ovary(3)|pancreas(1)|prostate(2)|skin(7)|stomach(1)	83			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACAAACAGTGAACTATCCTA	0.418000													79	120					0	0	0.003610	0	0
ABCB11	8647	broad.mit.edu	37	2	169825893	169825893	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:169825893C>T	ENST00000263817.6	-	16	2102	c.1978G>A	c.(1978-1980)Gga>Aga	p.G660R		NM_003742.2	NP_003733.2	O95342	ABCBB_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 11	660	Interaction with HAX1 (By similarity).				bile acid biosynthetic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|bile acid-exporting ATPase activity|canalicular bile acid transmembrane transporter activity|sodium-exporting ATPase activity, phosphorylative mechanism			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(16)|lung(26)|ovary(3)|stomach(1)	57					Adenosine triphosphate(DB00171)|Bosentan(DB00559)|Glibenclamide(DB01016)	GCTTGATTTCCCTGGCTTTGC	0.383000													4	13					0	0	0.000602	0	0
TET2	54790	broad.mit.edu	37	4	106156057	106156057	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:106156057G>A	ENST00000540549.1	+	3	1818	c.958G>A	c.(958-960)Gaa>Aaa	p.E320K	TET2_ENST00000305737.2_Missense_Mutation_p.E320K|TET2_ENST00000394764.1_Missense_Mutation_p.E320K|TET2_ENST00000513237.1_Missense_Mutation_p.E341K|TET2_ENST00000380013.4_Missense_Mutation_p.E320K|TET2_ENST00000413648.2_Missense_Mutation_p.E320K|TET2_ENST00000545826.1_Missense_Mutation_p.E320K			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	320					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		TCAGAAACCAGAACAACTACA	0.433000			"""Mis N, F"""		MDS								10	14					0	0	0.001368	0	0
CADM3	57863	broad.mit.edu	37	1	159166195	159166195	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:159166195C>T	ENST00000368125.4	+	6	890	c.733C>T	c.(733-735)Cgt>Tgt	p.R245C	CTA-134P22.2_ENST00000415675.2_RNA|CADM3_ENST00000368124.4_Missense_Mutation_p.R279C	NM_001127173.1	NP_001120645.1	Q8N126	CADM3_HUMAN	cell adhesion molecule 3	245	Ig-like C2-type 2.				adherens junction organization|cell junction assembly|heterophilic cell-cell adhesion|homophilic cell adhesion	cell-cell junction|integral to membrane	protein homodimerization activity	p.R279C(1)		NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(12)|lung(20)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55	all_hematologic(112;0.0429)					TCCCCATCCTCGTGAGGGCCA	0.517000											OREG0013913	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	29	11					0	0	0.003271	0	0
CSNK1A1L	122011	broad.mit.edu	37	13	37679096	37679096	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:37679096G>A	ENST00000379800.3	-	1	707	c.298C>T	c.(298-300)Ctc>Ttc	p.L100F		NM_145203.5	NP_660204.2	Q8N752	KC1AL_HUMAN	casein kinase 1, alpha 1-like	100	Protein kinase.				Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(3)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(10)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	37		Lung NSC(96;7.97e-05)|Breast(139;0.0615)|Lung SC(185;0.0743)|Prostate(109;0.109)		all cancers(112;3.58e-07)|Epithelial(112;1.29e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00695)|BRCA - Breast invasive adenocarcinoma(63;0.0117)|GBM - Glioblastoma multiforme(144;0.0407)		AAATTAAAGAGGTCTTCGAGG	0.443000													20	35					0	0	0.001882	0	0
SSH2	85464	broad.mit.edu	37	17	27959827	27959827	+	Silent	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:27959827C>A	ENST00000269033.3	-	15	2455	c.2304G>T	c.(2302-2304)ctG>ctT	p.L768L	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Silent_p.L795L	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	768					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TGTCTCCTTTCAGTTGAATCT	0.463000													11	41					6.40141e-05	0.000108389	0.000978	1	0
RUNX2	860	broad.mit.edu	37	6	45480082	45480082	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:45480082C>T	ENST00000371438.1	+	6	1317	c.959C>T	c.(958-960)cCg>cTg	p.P320L	RUNX2_ENST00000371432.3_Missense_Mutation_p.P306L|RUNX2_ENST00000359524.5_Missense_Mutation_p.P306L|RUNX2_ENST00000576263.1_Missense_Mutation_p.P320L|RUNX2_ENST00000352853.5_Missense_Mutation_p.P388L|RUNX2_ENST00000541979.1_Missense_Mutation_p.P388L|RUNX2_ENST00000465038.2_Missense_Mutation_p.P320L|RUNX2_ENST00000371436.6_Missense_Mutation_p.P320L	NM_001024630.3	NP_001019801.3	Q13950	RUNX2_HUMAN	runt-related transcription factor 2	320	Pro/Ser/Thr-rich.				negative regulation of transcription, DNA-dependent|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|liver(1)|lung(18)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	34						TCTACCACCCCGCTGTCTTCC	0.587000													27	110					0	0	0.005443	0	0
TMEM57	55219	broad.mit.edu	37	1	25812149	25812149	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:25812149C>T	ENST00000374343.4	+	8	1538	c.1359C>T	c.(1357-1359)atC>atT	p.I453I	TMEM57_ENST00000399766.3_Silent_p.I226I|TMEM57_ENST00000399763.3_Silent_p.I95I	NM_018202.4	NP_060672.2	Q8N5G2	MACOI_HUMAN	transmembrane protein 57	453						axon|integral to membrane|neuron projection terminus|nuclear membrane|synapse part				breast(3)|endometrium(2)|kidney(2)|large_intestine(8)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	27		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.00715)|all_lung(284;0.00989)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0675)|all_neural(195;0.201)		UCEC - Uterine corpus endometrioid carcinoma (279;0.042)|OV - Ovarian serous cystadenocarcinoma(117;1.85e-26)|Colorectal(126;2.99e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|STAD - Stomach adenocarcinoma(196;0.000766)|BRCA - Breast invasive adenocarcinoma(304;0.000986)|GBM - Glioblastoma multiforme(114;0.0191)|READ - Rectum adenocarcinoma(331;0.0649)		AGCAGAATATCAGCCAGTTGG	0.353000													39	64					0	0	0.007835	0	0
KERA	11081	broad.mit.edu	37	12	91445201	91445201	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:91445201C>T	ENST00000266719.3	-	3	1228	c.981G>A	c.(979-981)ctG>ctA	p.L327L		NM_007035.3	NP_008966.1	O60938	KERA_HUMAN	keratocan	327					response to stimulus|visual perception	proteinaceous extracellular matrix				breast(2)|large_intestine(8)|lung(5)|prostate(2)|skin(2)	19						CATTTCCATCCAGACGGAGGT	0.438000													20	40					0	0	0.001216	0	0
SETD4	54093	broad.mit.edu	37	21	37417917	37417917	+	Missense_Mutation	SNP	G	G	A	rs139822807		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:37417917G>A	ENST00000399215.1	-	5	2061	c.689C>T	c.(688-690)cCg>cTg	p.P230L	SETD4_ENST00000399208.2_Missense_Mutation_p.P230L|SETD4_ENST00000332131.4_Missense_Mutation_p.P230L|SETD4_ENST00000481477.1_5'UTR|SETD4_ENST00000399212.1_Missense_Mutation_p.P206L|SETD4_ENST00000399201.1_Missense_Mutation_p.P206L|SETD4_ENST00000399205.1_Missense_Mutation_p.P206L|SETD4_ENST00000399207.1_Missense_Mutation_p.P230L			Q9NVD3	SETD4_HUMAN	SET domain containing 4	230	SET.									autonomic_ganglia(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)	15						GTCCAGGTACGGAGCGAGTGC	0.587000													6	26					0	0	0.001984	0	0
ARHGAP33	115703	broad.mit.edu	37	19	36279003	36279003	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:36279003C>T	ENST00000007510.4	+	21	3680	c.3536C>T	c.(3535-3537)cCc>cTc	p.P1179L	ARHGAP33_ENST00000378944.5_Missense_Mutation_p.P1015L|ARHGAP33_ENST00000314737.5_Missense_Mutation_p.P1018L			O14559	RHG33_HUMAN	Rho GTPase activating protein 33	1179					cell communication|protein transport|signal transduction	intracellular	GTPase activator activity|phosphatidylinositol binding|protein binding			endometrium(7)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	37						CCCAGGGGTCCCTCACCTGCC	0.682000													14	33					0	0	0.004007	0	0
CRNN	49860	broad.mit.edu	37	1	152382122	152382122	+	Missense_Mutation	SNP	C	C	T	rs138795800		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:152382122C>T	ENST00000271835.3	-	3	1498	c.1436G>A	c.(1435-1437)cGa>cAa	p.R479Q	RP1-91G5.3_ENST00000411804.1_RNA	NM_016190.2	NP_057274.1	Q9UBG3	CRNN_HUMAN	cornulin	479					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTGATGCCTCGCTTCTCTTC	0.542000													16	68					0	0	0.004007	0	0
SPDEF	25803	broad.mit.edu	37	6	34508834	34508834	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:34508834C>T	ENST00000374037.3	-	3	975	c.561G>A	c.(559-561)tcG>tcA	p.S187S	SPDEF_ENST00000544425.1_Silent_p.S187S	NM_012391.2	NP_036523.1	O95238	SPDEF_HUMAN	SAM pointed domain containing ETS transcription factor	187	PNT.				negative regulation of survival gene product expression|negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(2)|skin(3)	15						ACTGCTCCTCCGACATGGCGC	0.652000													8	38					0	0	0.003080	0	0
ERO1LB	56605	broad.mit.edu	37	1	236384259	236384259	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:236384259C>T	ENST00000354619.5	-	15	1417	c.1216G>A	c.(1216-1218)Ggt>Agt	p.G406S	GPR137B_ENST00000477559.1_Intron	NM_019891.3	NP_063944.3	Q86YB8	ERO1B_HUMAN	ERO1-like beta (S. cerevisiae)	406					electron transport chain|protein thiol-disulfide exchange|transport	endoplasmic reticulum membrane	flavin adenine dinucleotide binding|oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor|unfolded protein binding			NS(1)|endometrium(3)|large_intestine(8)|lung(8)|skin(2)|urinary_tract(1)	23	Ovarian(103;0.0634)|Breast(184;0.247)	all_cancers(173;0.123)|Acute lymphoblastic leukemia(190;0.205)|Prostate(94;0.219)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)			GTTCCTAAACCCTGAGTCTAA	0.333000													11	46					0	0	0.000978	0	0
ATP7A	538	broad.mit.edu	37	X	77300981	77300981	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:77300981A>G	ENST00000341514.6	+	22	4293	c.4138A>G	c.(4138-4140)Att>Gtt	p.I1380V	ATP7A_ENST00000343533.5_Missense_Mutation_p.I1302V|ATP7A_ENST00000350425.4_Missense_Mutation_p.I383V	NM_000052.5	NP_000043.3	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1380					ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						TTTTATGCCCATTGGTTTGGT	0.343000													61	15					0	0	0.003610	0	0
TEKT2	27285	broad.mit.edu	37	1	36553171	36553171	+	Silent	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:36553171C>A	ENST00000207457.3	+	8	1114	c.987C>A	c.(985-987)ctC>ctA	p.L329L		NM_014466.2	NP_055281.2	Q9UIF3	TEKT2_HUMAN	tektin 2 (testicular)	329				L -> F (in Ref. 1; AAC09343).	cell projection organization|microtubule cytoskeleton organization	actin cytoskeleton|cilium axoneme|flagellar axoneme|focal adhesion|microtubule|nucleolus				breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(2)|pancreas(1)|skin(2)	13		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				ACGTGGAACTCTGCCGGGACC	0.617000													9	19					6.40141e-05	0.000108389	0.000978	1	0
CFTR	1080	broad.mit.edu	37	7	117182159	117182159	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:117182159G>A	ENST00000003084.6	+	9	1338	c.1206G>A	c.(1204-1206)gaG>gaA	p.E402E	CFTR_ENST00000454343.1_Silent_p.E402E	NM_000492.3	NP_000483.3	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)	402					respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	CCTTCTGGGAGGAGGTCAGAA	0.308000									Cystic Fibrosis				12	18					0	0	0.001855	0	0
TIAM1	7074	broad.mit.edu	37	21	32554872	32554872	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:32554872G>A	ENST00000286827.3	-	16	3224	c.2753C>T	c.(2752-2754)cCc>cTc	p.P918L	TIAM1_ENST00000541036.1_Missense_Mutation_p.P858L	NM_003253.2	NP_003244.2	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	918					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			autonomic_ganglia(3)|breast(7)|central_nervous_system(2)|endometrium(13)|kidney(4)|large_intestine(33)|lung(44)|ovary(2)|prostate(3)|skin(2)|urinary_tract(2)	115						GCCCAGCGAGGGCTGTGAGAG	0.597000													24	47					0	0	0.003330	0	0
PCDHB4	56131	broad.mit.edu	37	5	140501932	140501932	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140501932G>A	ENST00000194152.1	+	1	352	c.352G>A	c.(352-354)Gga>Aga	p.G118R		NM_018938.2	NP_061761.1	Q9Y5E5	PCDB4_HUMAN		118	Cadherin 1.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	cytoplasm|integral to plasma membrane|intermediate filament cytoskeleton	calcium ion binding			autonomic_ganglia(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|lung(35)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	67			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ATTTTTTCAAGGAGAATTATT	0.433000													16	66					0	0	0.004990	0	0
LILRB1	10859	broad.mit.edu	37	19	55144129	55144129	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55144129G>A	ENST00000396331.1	+	7	1233	c.876G>A	c.(874-876)ggG>ggA	p.G292G	LILRB1_ENST00000418536.2_Silent_p.G292G|LILRB1_ENST00000396317.1_Silent_p.G292G|LILRB1_ENST00000396321.2_Silent_p.G292G|LILRB1_ENST00000434867.2_Silent_p.G292G|LILRB1_ENST00000324602.7_Silent_p.G292G|LILRB1_ENST00000427581.2_Silent_p.G328G|LILRB1_ENST00000396332.4_Silent_p.G292G|LILRB1_ENST00000448689.1_Silent_p.G292G|LILRB1_ENST00000396315.1_Silent_p.G292G|LILRB1_ENST00000396327.3_Silent_p.G292G	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	292	Ig-like C2-type 3.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		GCTCCTACGGGGGCCAGTACA	0.672000										HNSCC(37;0.09)			22	43					0	0	0.005443	0	0
GAS2L1	10634	broad.mit.edu	37	22	29708302	29708302	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:29708302C>T	ENST00000406549.3	+	6	1331	c.1181C>T	c.(1180-1182)cCc>cTc	p.P394L	GAS2L1_ENST00000407854.1_3'UTR|GAS2L1_ENST00000407647.2_3'UTR|GAS2L1_ENST00000471961.1_3'UTR|GAS2L1_ENST00000403764.1_3'UTR|GAS2L1_ENST00000360113.2_3'UTR			Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1	398					cell cycle arrest	cytoplasm|cytoskeleton				endometrium(2)|lung(2)|prostate(1)	5						CCTGGGAGCCCCCTGGCTTGC	0.682000													25	18					0	0	0.004656	0	0
DNAH11	8701	broad.mit.edu	37	7	21805179	21805179	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:21805179G>A	ENST00000328843.6	+	56	9126	c.9095G>A	c.(9094-9096)aGg>aAg	p.R3032K	DNAH11_ENST00000409508.3_Missense_Mutation_p.R3025K			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	3032	AAA 4 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GTCAGCAGGAGGTTCATTGAG	0.537000									Kartagener syndrome				7	20					0	0	0.001984	0	0
LONP1	9361	broad.mit.edu	37	19	5719871	5719871	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:5719871C>T	ENST00000360614.3	-	1	430	c.273G>A	c.(271-273)gaG>gaA	p.E91E	LONP1_ENST00000540670.2_Intron|LONP1_ENST00000590511.1_5'UTR|LONP1_ENST00000585374.1_Intron|LONP1_ENST00000593119.1_Intron	NM_004793.2	NP_004784.2	P36776	LONM_HUMAN	lon peptidase 1, mitochondrial	91					cellular chaperone-mediated protein complex assembly|cellular response to oxidative stress|misfolded or incompletely synthesized protein catabolic process|mitochondrial DNA metabolic process|oxidation-dependent protein catabolic process|protein homooligomerization|response to hypoxia	mitochondrial nucleoid	ADP binding|ATP binding|ATP-dependent peptidase activity|DNA polymerase binding|G-quadruplex DNA binding|mitochondrial heavy strand promoter anti-sense binding|mitochondrial light strand promoter anti-sense binding|sequence-specific DNA binding|serine-type endopeptidase activity|single-stranded DNA binding|single-stranded RNA binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(12)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						cggcTCCTTCCTCCGCGCCGC	0.746000													3	3					0	0	0.004672	0	0
SLAMF9	89886	broad.mit.edu	37	1	159921548	159921548	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:159921548C>T	ENST00000368093.3	-	4	889	c.773G>A	c.(772-774)cGa>cAa	p.R258Q	SLAMF9_ENST00000466773.1_5'UTR|SLAMF9_ENST00000368092.3_Missense_Mutation_p.R167Q	NM_033438.3	NP_254273.2	Q96A28	SLAF9_HUMAN	SLAM family member 9	258						integral to membrane				breast(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(1)|urinary_tract(1)	13	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TTTCTGGACTCGGATGACCCA	0.498000													51	68					0	0	0.003610	0	0
RELN	5649	broad.mit.edu	37	7	103185575	103185575	+	Silent	SNP	G	G	A	rs146913017	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:103185575G>A	ENST00000428762.1	-	42	6678	c.6519C>T	c.(6517-6519)ttC>ttT	p.F2173F	RELN_ENST00000424685.2_Silent_p.F2173F|RELN_ENST00000343529.5_Silent_p.F2173F	NM_005045.3	NP_005036.2	P78509	RELN_HUMAN	reelin	2173					axon guidance|cell adhesion|cerebral cortex tangential migration|glial cell differentiation|neuron migration|peptidyl-tyrosine phosphorylation|positive regulation of protein kinase activity|positive regulation of small GTPase mediated signal transduction|response to pain|spinal cord patterning	cytoplasm|dendrite|extracellular space|proteinaceous extracellular matrix	metal ion binding|protein serine/threonine/tyrosine kinase activity|serine-type peptidase activity			NS(3)|breast(8)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(4)|kidney(6)|large_intestine(43)|lung(101)|ovary(9)|pancreas(2)|prostate(4)|skin(14)|stomach(2)|upper_aerodigestive_tract(12)|urinary_tract(2)	227				COAD - Colon adenocarcinoma(1;8.98e-05)|Colorectal(1;0.00184)		GACTACCTTCGAAATCATCTT	0.323000													15	18					0	0	0.002450	0	0
PAPSS2	9060	broad.mit.edu	37	10	89475534	89475534	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:89475534C>T	ENST00000361175.4	+	7	1168	c.799C>T	c.(799-801)Ccc>Tcc	p.P267S	PAPSS2_ENST00000456849.1_Missense_Mutation_p.P267S|PAPSS2_ENST00000427144.2_Missense_Mutation_p.P271S	NM_004670.3	NP_004661.2	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	267					3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|skin(1)|stomach(1)	20		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		CTGGGCCACTCCCCTCAAAGG	0.443000													25	35					0	0	0.005443	0	0
NOTCH4	4855	broad.mit.edu	37	6	32188373	32188373	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32188373G>A	ENST00000375023.3	-	6	1106	c.968C>T	c.(967-969)cCc>cTc	p.P323L		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	323	EGF-like 8; calcium-binding (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GCAGTGAGGGGGACCCTGGGT	0.627000													57	268					0	0	0.003610	0	0
ZNF446	55663	broad.mit.edu	37	19	58988866	58988866	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:58988866C>T	ENST00000596341.1	+	2	2501	c.281C>T	c.(280-282)cCt>cTt	p.P94L	ZNF446_ENST00000594369.1_Missense_Mutation_p.P94L|ZNF446_ENST00000335841.4_Missense_Mutation_p.P94L			Q9NWS9	ZN446_HUMAN	zinc finger protein 446	94	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|skin(1)	8		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0164)|Lung(386;0.179)		CCAGGCAGTCCTGAGGAGGCC	0.637000													6	45					0	0	0.001168	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43919740	43919740	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:43919740G>A	ENST00000282406.4	+	4	384	c.274G>A	c.(274-276)Gag>Aag	p.E92K		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	92						cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TCAAGATCTGGAGTCGCTAAT	0.338000													95	243					0	0	0.003610	0	0
LILRB1	10859	broad.mit.edu	37	19	55143506	55143506	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55143506G>A	ENST00000396331.1	+	6	836	c.479G>A	c.(478-480)gGa>gAa	p.G160E	LILRB1_ENST00000418536.2_Missense_Mutation_p.G160E|LILRB1_ENST00000396317.1_Missense_Mutation_p.G160E|LILRB1_ENST00000396321.2_Missense_Mutation_p.G160E|LILRB1_ENST00000434867.2_Missense_Mutation_p.G160E|LILRB1_ENST00000324602.7_Missense_Mutation_p.G160E|LILRB1_ENST00000427581.2_Missense_Mutation_p.G196E|LILRB1_ENST00000396332.4_Missense_Mutation_p.G160E|LILRB1_ENST00000448689.1_Missense_Mutation_p.G160E|LILRB1_ENST00000396315.1_Missense_Mutation_p.G160E|LILRB1_ENST00000396327.3_Missense_Mutation_p.G160E	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	160	Ig-like C2-type 2.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		TGTAAGGAAGGAGAAGATGAA	0.607000										HNSCC(37;0.09)			27	47					0	0	0.005443	0	0
NCAM1	4684	broad.mit.edu	37	11	113130934	113130934	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:113130934C>T	ENST00000316851.7	+	15	1990	c.1990C>T	c.(1990-1992)Ctg>Ttg	p.L664L	NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000533760.1_Silent_p.L546L	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	674	Fibronectin type-III 2.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		GCTGAAGTCCCTGGACTGGAA	0.557000													12	32					0	0	0.000978	0	0
COL2A1	1280	broad.mit.edu	37	12	48367243	48367243	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:48367243C>T	ENST00000380518.3	-	54	4575	c.4411G>A	c.(4411-4413)Gga>Aga	p.G1471R	COL2A1_ENST00000493991.1_5'UTR|COL2A1_ENST00000337299.6_Missense_Mutation_p.G1402R	NM_001844.4|NM_033150.2	NP_001835.3|NP_149162.2	P02458	CO2A1_HUMAN	collagen, type II, alpha 1	1471	Fibrillar collagen NC1.				axon guidance|collagen fibril organization|embryonic skeletal joint morphogenesis|sensory perception of sound|visual perception	collagen type II	identical protein binding|platelet-derived growth factor binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|lung(25)|ovary(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(3)	64		Acute lymphoblastic leukemia(13;0.108)|all_hematologic(14;0.214)			Collagenase(DB00048)	TCGGGCCCTCCTATGTCCATG	0.527000													37	87					0	0	0.006230	0	0
TLR7	51284	broad.mit.edu	37	X	12906412	12906412	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:12906412G>A	ENST00000380659.3	+	3	2924	c.2785G>A	c.(2785-2787)Gag>Aag	p.E929K		NM_016562.3	NP_057646.1	Q9NYK1	TLR7_HUMAN	toll-like receptor 7	929	TIR.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			NS(1)|breast(4)|endometrium(5)|kidney(1)|large_intestine(8)|lung(18)|ovary(2)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	44					Imiquimod(DB00724)	TTTATGTCTCGAGGAAAGGGA	0.468000													77	7					0	0	0.003610	0	0
SFSWAP	6433	broad.mit.edu	37	12	132238958	132238958	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:132238958C>T	ENST00000261674.4	+	9	1509	c.1368C>T	c.(1366-1368)gtC>gtT	p.V456V	SFSWAP_ENST00000541286.1_Silent_p.V456V	NM_004592.3	NP_004583.2	Q12872	SFSWA_HUMAN	splicing factor, suppressor of white-apricot homolog (Drosophila)	456					mRNA splice site selection|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(8)|ovary(1)|skin(2)	25						CCCCCGACGTCCAGCCCGTGA	0.602000													11	30					0	0	0.000673	0	0
OR2A5	393046	broad.mit.edu	37	7	143748115	143748115	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:143748115G>A	ENST00000408906.2	+	1	655	c.621G>A	c.(619-621)ctG>ctA	p.L207L		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	207					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					TGTTCATCCTGGTGGGGCCGC	0.582000													40	47					0	0	0.007835	0	0
CNTN5	53942	broad.mit.edu	37	11	100170010	100170010	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:100170010C>T	ENST00000524871.1	+	20	2792	c.2502C>T	c.(2500-2502)ttC>ttT	p.F834F	CNTN5_ENST00000418526.2_Silent_p.F760F|CNTN5_ENST00000524560.1_3'UTR|CNTN5_ENST00000279463.3_Silent_p.F834F|CNTN5_ENST00000528682.1_Silent_p.F834F|CNTN5_ENST00000527185.1_Silent_p.F834F	NM_014361.3	NP_055176.1	O94779	CNTN5_HUMAN	contactin 5	834	Fibronectin type-III 2.				cell adhesion	anchored to membrane|plasma membrane	protein binding			NS(2)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(12)|lung(38)|ovary(2)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	81		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		CTTCCAAATTCATTTATCGAG	0.428000													36	3					0	0	0.004878	0	0
ATP1A4	480	broad.mit.edu	37	1	160151744	160151744	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:160151744C>T	ENST00000368081.4	+	20	3363	c.2892C>T	c.(2890-2892)atC>atT	p.I964I	ATP1A4_ENST00000470705.1_Silent_p.I100I|ATP1A4_ENST00000418334.1_3'UTR	NM_144699.3	NP_653300.2	Q13733	AT1A4_HUMAN	ATPase, Na+/K+ transporting, alpha 4 polypeptide	964					ATP biosynthetic process|ATP hydrolysis coupled proton transport|regulation of cellular pH|sperm motility	sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(34)|ovary(2)|prostate(4)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	75	all_cancers(52;2.56e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TATTTGGGATCCTGGAGGAGA	0.522000													53	188					0	0	0.003610	0	0
PDZRN3	23024	broad.mit.edu	37	3	73432519	73432519	+	Silent	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:73432519T>A	ENST00000263666.4	-	10	3312	c.3198A>T	c.(3196-3198)gtA>gtT	p.V1066V	PDZRN3_ENST00000479530.1_Silent_p.V783V|PDZRN3_ENST00000535920.1_Silent_p.V788V|PDZRN3_ENST00000466780.1_Silent_p.V723V|PDZRN3_ENST00000462146.2_Silent_p.V723V	NM_015009.1	NP_055824.1	Q9UPQ7	PZRN3_HUMAN	PDZ domain containing ring finger 3	1066							ubiquitin-protein ligase activity|zinc ion binding			breast(2)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(13)|lung(31)|ovary(4)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69		Prostate(10;0.114)|Lung NSC(201;0.187)|Lung SC(41;0.236)		BRCA - Breast invasive adenocarcinoma(55;0.00041)|Epithelial(33;0.0023)|LUSC - Lung squamous cell carcinoma(21;0.0048)|Lung(16;0.0105)|KIRC - Kidney renal clear cell carcinoma(39;0.111)|Kidney(39;0.134)		GTGAAAATTATACAGTAGTCA	0.423000													30	75					0	0	0.002096	0	0
PRICKLE1	144165	broad.mit.edu	37	12	42853644	42853644	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:42853644C>T	ENST00000455697.1	-	8	2748	c.2463G>A	c.(2461-2463)aaG>aaA	p.K821K	PRICKLE1_ENST00000548696.1_Silent_p.K821K|PRICKLE1_ENST00000445766.2_Silent_p.K821K|PRICKLE1_ENST00000552240.1_Silent_p.K821K|PRICKLE1_ENST00000345127.3_Silent_p.K821K|RP11-328C8.4_ENST00000547824.1_RNA	NM_001144882.1|NM_001144883.1	NP_001138354.1|NP_001138355.1	Q96MT3	PRIC1_HUMAN	prickle homolog 1 (Drosophila)	821	Poly-Lys.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cardiac muscle cell myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein import into nucleus	cytosol|nuclear membrane	zinc ion binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(12)|liver(1)|lung(13)|ovary(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	47	all_cancers(12;4.25e-05)|Breast(8;0.176)			GBM - Glioblastoma multiforme(48;0.2)		CCTTGTGTCCCTTTTTCTTCT	0.398000													22	104					0	0	0.001882	0	0
ZNF12	7559	broad.mit.edu	37	7	6731942	6731942	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:6731942G>A	ENST00000405858.1	-	5	1172	c.631C>T	c.(631-633)Cgt>Tgt	p.R211C	AC073343.13_ENST00000366167.2_RNA|ZNF12_ENST00000404360.1_Missense_Mutation_p.R137C|ZNF12_ENST00000342651.5_Missense_Mutation_p.R173C	NM_006956.2|NM_016265.3	NP_008887.2|NP_057349.2	P17014	ZNF12_HUMAN	zinc finger protein 12	211					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|endometrium(1)|large_intestine(1)|lung(7)|prostate(2)|upper_aerodigestive_tract(3)	16		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		TCCAAAATACGAATTTTCTGA	0.328000													10	94					0	0	0.000673	0	0
COL14A1	7373	broad.mit.edu	37	8	121383402	121383402	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:121383402G>A	ENST00000297848.3	+	48	5593	c.5323G>A	c.(5323-5325)Gat>Aat	p.D1775N	COL14A1_ENST00000247781.3_Missense_Mutation_p.D1680N	NM_021110.1	NP_066933.1	Q05707	COEA1_HUMAN	collagen, type XIV, alpha 1	1775	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			TCCCCATCCAGATCAGCCAGA	0.522000													33	212					0	0	0.004878	0	0
MSI1	4440	broad.mit.edu	37	12	120794811	120794811	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:120794811C>T	ENST00000257552.2	-	9	634	c.546G>A	c.(544-546)aaG>aaA	p.K182K	MSI1_ENST00000546622.1_5'UTR	NM_002442.3	NP_002433.1	O43347	MSI1H_HUMAN	musashi RNA-binding protein 1	182	RRM 2.				nervous system development	cytoplasm|nucleus	nucleotide binding			breast(4)|central_nervous_system(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(5)|skin(2)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCTGAGCTTTCTTACATTCCA	0.532000											OREG0022190	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	22	46					0	0	0.003954	0	0
SLC7A9	11136	broad.mit.edu	37	19	33350862	33350862	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:33350862G>A	ENST00000023064.4	-	8	949	c.758C>T	c.(757-759)cCt>cTt	p.P253L	SLC7A9_ENST00000587772.1_Missense_Mutation_p.P253L|SLC7A9_ENST00000590341.1_Missense_Mutation_p.P253L	NM_001126335.1|NM_001243036.1|NM_014270.4	NP_001119807.1|NP_001229965.1|NP_055085.1	P82251	BAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	253					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	AATGGCCAAAGGCAGGTTTCT	0.602000													9	26					0	0	0.001368	0	0
OR5L1	219437	broad.mit.edu	37	11	55578978	55578978	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:55578978C>T	ENST00000333973.2	+	1	125	c.36C>T	c.(34-36)ttC>ttT	p.F12F		NM_001004738.1	NP_001004738.1	Q8NGL2	OR5L1_HUMAN	olfactory receptor, family 5, subfamily L, member 1	12					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(2)|endometrium(2)|kidney(3)|large_intestine(4)|liver(4)|lung(36)|ovary(2)|pancreas(1)|prostate(5)|skin(9)|stomach(4)|upper_aerodigestive_tract(3)	78		all_epithelial(135;0.208)				TGGCTGAGTTCATTCTCCTTG	0.423000													55	250					0	0	0.003610	0	0
SETD8	387893	broad.mit.edu	37	12	123892187	123892187	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:123892187C>T	ENST00000402868.3	+	8	1422	c.996C>T	c.(994-996)ctC>ctT	p.L332L	SETD8_ENST00000330479.4_Silent_p.L332L			Q9NQR1	SETD8_HUMAN	SET domain containing (lysine methyltransferase) 8	373	SET.				cell division|mitosis|negative regulation of transcription from RNA polymerase II promoter|peptidyl-lysine monomethylation|regulation of DNA damage response, signal transduction by p53 class mediator|transcription, DNA-dependent	chromosome|nucleus	histone-lysine N-methyltransferase activity|p53 binding|transcription corepressor activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(4)|prostate(3)|urinary_tract(1)	13	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.00101)|Epithelial(86;0.00425)		GGGAGGAGCTCCTGTATGACT	0.612000													8	25					0	0	0.004482	0	0
POM121L12	285877	broad.mit.edu	37	7	53103702	53103702	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:53103702C>T	ENST00000408890.4	+	1	354	c.338C>T	c.(337-339)tCc>tTc	p.S113F		NM_182595.3	NP_872401.3	Q8N7R1	P1L12_HUMAN	POM121 transmembrane nucleoporin-like 12	113										endometrium(5)|kidney(1)|large_intestine(5)|lung(44)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)	61						CGAGACCTCTCCTGTGCCTGG	0.721000													6	23					0	0	0.003080	0	0
TM9SF4	9777	broad.mit.edu	37	20	30747839	30747839	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:30747839C>T	ENST00000217315.5	+	16	1903	c.1563C>T	c.(1561-1563)ttC>ttT	p.F521F	TM9SF4_ENST00000398022.2_Silent_p.F538F			Q92544	TM9S4_HUMAN	transmembrane 9 superfamily protein member 4	538						integral to membrane				central_nervous_system(2)|kidney(1)|large_intestine(4)|lung(8)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	20			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GCTTCCTGTTCCTTGTTTTCA	0.542000													24	62					0	0	0.002780	0	0
CLU	1191	broad.mit.edu	37	8	27462528	27462528	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:27462528G>A	ENST00000316403.10	-	5	1147	c.742C>T	c.(742-744)Ctt>Ttt	p.L248F	CLU_ENST00000546343.1_Missense_Mutation_p.L259F|CLU_ENST00000405140.3_Missense_Mutation_p.L248F|CLU_ENST00000523500.1_Missense_Mutation_p.L248F|CLU_ENST00000560366.1_Missense_Mutation_p.L300F			P10909	CLUS_HUMAN	clusterin	248					chaperone-mediated protein folding|complement activation, classical pathway|innate immune response|lipid metabolic process|negative regulation of apoptosis|negative regulation of protein homooligomerization|platelet activation|platelet degranulation|positive regulation of NF-kappaB transcription factor activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|response to misfolded protein|response to virus|reverse cholesterol transport	chromaffin granule|cytosol|endoplasmic reticulum|microsome|mitochondrial membrane|nucleus|perinuclear region of cytoplasm|platelet alpha granule lumen|spherical high-density lipoprotein particle	misfolded protein binding|ubiquitin protein ligase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)	21		Ovarian(32;2.61e-05)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|Colorectal(74;0.132)		ATCATCTCAAGGAAGGGCTGG	0.577000													32	62					0	0	0.002836	0	0
SZT2	23334	broad.mit.edu	37	1	43895512	43895512	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:43895512C>T	ENST00000562955.1	+	28	4134	c.4134C>T	c.(4132-4134)atC>atT	p.I1378I	SZT2_ENST00000372442.1_Silent_p.I536I	NM_015284.3	NP_056099.3	Q5T011	SZT2_HUMAN	seizure threshold 2 homolog (mouse)	1435						peroxisome				NS(2)|breast(9)|central_nervous_system(1)|endometrium(17)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(19)|lung(39)|ovary(4)|pancreas(3)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	113						ATAGCGTCATCCAGGTGGGAA	0.597000													32	56					0	0	0.002096	0	0
AHNAK	79026	broad.mit.edu	37	11	62296260	62296260	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:62296260C>T	ENST00000378024.4	-	5	5903	c.5629G>A	c.(5629-5631)Gtg>Atg	p.V1877M	AHNAK_ENST00000257247.7_Intron|AHNAK_ENST00000530124.1_Intron	NM_001620.1	NP_001611.1	Q09666	AHNK_HUMAN	AHNAK nucleoprotein	1877					nervous system development	nucleus	protein binding			NS(3)|autonomic_ganglia(1)|breast(10)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(33)|large_intestine(40)|liver(1)|lung(108)|ovary(13)|pancreas(4)|prostate(5)|skin(16)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(6)	268		Melanoma(852;0.155)				AATTTTGGCACCGACACATCC	0.517000													57	80					0	0	0.003610	0	0
CCDC66	285331	broad.mit.edu	37	3	56627978	56627978	+	Silent	SNP	C	C	T	rs140193610		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:56627978C>T	ENST00000394672.3	+	10	1396	c.1326C>T	c.(1324-1326)ctC>ctT	p.L442L	CCDC66_ENST00000326595.7_Silent_p.L408L|CCDC66_ENST00000436465.2_Silent_p.L442L	NM_001012506.4|NM_001141947.1	NP_001012524.4|NP_001135419.1	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66	442										breast(1)|kidney(1)|large_intestine(2)|liver(1)|lung(4)|skin(2)|urinary_tract(1)	12				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		CCAGCTTTCTCCGTTCTATGA	0.363000													13	45					0	0	0.001855	0	0
PCNXL2	80003	broad.mit.edu	37	1	233394984	233394984	+	Silent	SNP	C	C	T	rs117316984	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:233394984C>T	ENST00000258229.8	-	5	858	c.624G>A	c.(622-624)acG>acA	p.T208T	PCNXL2_ENST00000430153.1_5'UTR	NM_014801.3	NP_055616.3	A6NKB5	PCX2_HUMAN	pecanex-like 2 (Drosophila)	208						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(16)|kidney(7)|large_intestine(19)|lung(30)|pancreas(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86		all_cancers(173;0.0347)|Prostate(94;0.137)				CTGACTTGGTCGTGGTTTCCA	0.478000													69	74					0	0	0.003610	0	0
HTR3E	285242	broad.mit.edu	37	3	183822694	183822694	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:183822694C>T	ENST00000415389.2	+	5	975	c.509C>T	c.(508-510)cCc>cTc	p.P170L	HTR3E-AS1_ENST00000431427.1_RNA|HTR3E_ENST00000425359.2_Missense_Mutation_p.P155L|HTR3E_ENST00000440596.2_Missense_Mutation_p.P196L|HTR3E_ENST00000335304.2_Missense_Mutation_p.P185L|HTR3E_ENST00000436361.2_Missense_Mutation_p.P170L	NM_001256613.1|NM_198313.2	NP_001243542.1|NP_938055.1	A5X5Y0	5HT3E_HUMAN	5-hydroxytryptamine (serotonin) receptor 3E, ionotropic	170						integral to membrane|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(20)|ovary(1)|skin(2)|upper_aerodigestive_tract(2)	40	all_cancers(143;1.46e-10)|Ovarian(172;0.0303)		Epithelial(37;7.06e-36)|OV - Ovarian serous cystadenocarcinoma(80;3.11e-22)			TTCTACTTCCCCTTCGACCAG	0.478000													19	68					0	0	0.001882	0	0
PXDNL	137902	broad.mit.edu	37	8	52320734	52320734	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:52320734G>A	ENST00000356297.4	-	17	3550	c.3450C>T	c.(3448-3450)atC>atT	p.I1150I	PXDNL_ENST00000543296.1_Silent_p.I1150I	NM_144651.4	NP_653252.3	A1KZ92	PXDNL_HUMAN	peroxidasin homolog (Drosophila)-like	1150					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity	p.I349I(1)|p.I1150I(1)		NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(6)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	48		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CATATGGTGGGATCCCGTGGT	0.448000													44	158					0	0	0.003610	0	0
SUN5	140732	broad.mit.edu	37	20	31583448	31583448	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:31583448C>T	ENST00000356173.3	-	8	603	c.511G>A	c.(511-513)Gag>Aag	p.E171K	SUN5_ENST00000375523.3_Missense_Mutation_p.E146K	NM_080675.3	NP_542406.2	Q8TC36	SUN5_HUMAN	Sad1 and UNC84 domain containing 5	171					spermatogenesis					endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	25						GCTTCCATCTCCTGGAGCTTG	0.502000													73	234					0	0	0.003610	0	0
PRDM1	639	broad.mit.edu	37	6	106552934	106552934	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:106552934C>T	ENST00000369096.4	+	5	1133	c.899C>T	c.(898-900)cCc>cTc	p.P300L	PRDM1_ENST00000369091.2_Missense_Mutation_p.P264L|PRDM1_ENST00000369089.3_Missense_Mutation_p.P166L	NM_001198.3	NP_001189.2	O75626	PRDM1_HUMAN	PR domain containing 1, with ZNF domain	300					negative regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(4)|endometrium(5)|haematopoietic_and_lymphoid_tissue(59)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(5)|urinary_tract(2)	94	Breast(9;0.022)	all_cancers(87;2.2e-31)|all_epithelial(87;2.03e-21)|Acute lymphoblastic leukemia(125;4.99e-11)|all_lung(197;7.55e-09)|all_hematologic(75;5.82e-08)|Lung NSC(302;1.28e-06)|Colorectal(196;0.0112)|Ovarian(999;0.0365)		all cancers(137;1.83e-46)|Epithelial(106;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(136;1.99e-20)|GBM - Glioblastoma multiforme(226;3.72e-11)|BRCA - Breast invasive adenocarcinoma(108;1.38e-05)		GTCGTTTACCCCATCCGGGCC	0.552000			"""D, N, Mis, F, S"""		DLBCL								44	63					0	0	0.001951	0	0
PRC1	9055	broad.mit.edu	37	15	91512731	91512731	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:91512731G>A	ENST00000361188.5	-	13	2906	c.1695C>T	c.(1693-1695)ccC>ccT	p.P565P	PRC1_ENST00000361919.3_Intron|PRC1-AS1_ENST00000554388.1_RNA|PRC1_ENST00000394249.3_Silent_p.P565P|PRC1_ENST00000442656.2_Intron|PRC1-AS1_ENST00000556200.1_RNA			O43663	PRC1_HUMAN	protein regulator of cytokinesis 1	565	Unstructured, Arg/Lys rich.				cytokinesis|mitotic spindle elongation	cytoplasm|nucleus|spindle microtubule|spindle pole	protein binding			endometrium(1)|kidney(2)|large_intestine(7)|lung(9)|ovary(3)|prostate(1)|skin(2)	25	Lung NSC(78;0.0987)|all_lung(78;0.175)					TGCGCTGGAGGGGGGCCGAGC	0.542000													153	253					0	0	0.003610	0	0
TRIM55	84675	broad.mit.edu	37	8	67086797	67086797	+	Missense_Mutation	SNP	C	C	T	rs149867342		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:67086797C>T	ENST00000315962.4	+	10	1989	c.1616C>T	c.(1615-1617)tCc>tTc	p.S539F	TRIM55_ENST00000276573.7_3'UTR|TRIM55_ENST00000350034.4_Missense_Mutation_p.S232F|TRIM55_ENST00000353317.5_Missense_Mutation_p.S443F	NM_184085.1	NP_908973.1	Q9BYV6	TRI55_HUMAN	tripartite motif containing 55	539						cytoplasm|microtubule|nucleus	signal transducer activity|zinc ion binding	p.S539F(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(13)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(2)	39		Lung NSC(129;0.138)|all_lung(136;0.221)	Epithelial(68;0.0136)|all cancers(69;0.0582)|BRCA - Breast invasive adenocarcinoma(89;0.0628)|OV - Ovarian serous cystadenocarcinoma(28;0.0904)			CATATCTTCTCCTTTTCCTGG	0.547000													32	229					0	0	0.002836	0	0
MUC2	4583	broad.mit.edu	37	11	1102137	1102137	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:1102137G>A	ENST00000441003.2	+	44	7800	c.7773G>A	c.(7771-7773)gtG>gtA	p.V2591V		NM_002457.2	NP_002448.2	Q02817	MUC2_HUMAN	mucin 2, oligomeric mucus/gel-forming	4953						inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	CGGACAAGGTGGACAACAACA	0.617000													21	22					0	0	0.002299	0	0
ADCY5	111	broad.mit.edu	37	3	123003528	123003528	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:123003528C>G	ENST00000462833.1	-	21	4925	c.3713G>C	c.(3712-3714)cGg>cCg	p.R1238P	ADCY5_ENST00000309879.5_Missense_Mutation_p.R888P|ADCY5_ENST00000491190.1_Missense_Mutation_p.R896P	NM_183357.2	NP_899200.1	O95622	ADCY5_HUMAN	adenylate cyclase 5	1238					activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(2)|endometrium(4)|kidney(3)|large_intestine(12)|lung(22)|ovary(5)|prostate(2)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(2)	60				GBM - Glioblastoma multiforme(114;0.0342)		GACCACGCCCCGGCACTCCAG	0.607000													32	104					0	0	0.004878	0	0
SLC39A14	23516	broad.mit.edu	37	8	22275267	22275267	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:22275267C>T	ENST00000359741.5	+	8	1426	c.1251C>T	c.(1249-1251)atC>atT	p.I417I	SLC39A14_ENST00000289952.5_Silent_p.I417I|SLC39A14_ENST00000381237.1_Silent_p.I417I|SLC39A14_ENST00000240095.6_Silent_p.I417I	NM_015359.4	NP_056174.2	Q15043	S39AE_HUMAN	solute carrier family 39 (zinc transporter), member 14	417						endoplasmic reticulum|Golgi apparatus|integral to membrane|lamellipodium|plasma membrane	zinc ion transmembrane transporter activity			NS(1)|endometrium(4)|large_intestine(2)|lung(4)|prostate(1)	12				Colorectal(74;0.019)|COAD - Colon adenocarcinoma(73;0.0731)		CCTTTGGCATCCTGGCCGGCA	0.502000													24	64					0	0	0.002780	0	0
LINGO2	158038	broad.mit.edu	37	9	27950484	27950484	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:27950484C>T	ENST00000379992.2	-	6	635	c.186G>A	c.(184-186)ttG>ttA	p.L62L	LINGO2_ENST00000308675.3_Silent_p.L62L	NM_152570.2	NP_689783.1	Q7L985	LIGO2_HUMAN	leucine rich repeat and Ig domain containing 2	62						integral to membrane				autonomic_ganglia(1)|breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|liver(1)|lung(13)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	44	Melanoma(11;0.242)	all_neural(11;2.78e-09)		UCEC - Uterine corpus endometrioid carcinoma (5;0.0818)|GBM - Glioblastoma multiforme(2;1.31e-34)|all cancers(2;2.37e-25)|Lung(2;7.48e-08)|LUSC - Lung squamous cell carcinoma(38;5.09e-07)|KIRC - Kidney renal clear cell carcinoma(2;0.0465)|Kidney(2;0.0604)		TACTGAGGTCCAAGATTTTGG	0.468000													39	58					0	0	0.006230	0	0
RADIL	55698	broad.mit.edu	37	7	4856095	4856095	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:4856095G>A	ENST00000399583.3	-	8	1917	c.1728_splice	c.e8-1	p.S577_splice	RADIL_ENST00000536091.1_Splice_Site_p.V523_splice|RADIL_ENST00000538469.1_Splice_Site_p.S337_splice	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	577	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		GATGTACAGGGACTGGCGGGG	0.692000													10	103					0	0	0.000673	0	0
RGS20	8601	broad.mit.edu	37	8	54852200	54852200	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:54852200G>A	ENST00000297313.3	+	3	667	c.575G>A	c.(574-576)gGc>gAc	p.G192D	RGS20_ENST00000522225.1_Intron|RGS20_ENST00000276500.4_Missense_Mutation_p.G45D|RGS20_ENST00000344277.6_Missense_Mutation_p.G77D	NM_170587.2	NP_733466.1	O76081	RGS20_HUMAN	regulator of G-protein signaling 20	192					negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|nucleus|plasma membrane	GTPase activator activity|protein binding|signal transducer activity			breast(2)|endometrium(1)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(7;1.37e-06)|Epithelial(17;0.000126)|all cancers(17;0.0009)			GACACACCAGGCGCCGCCCCA	0.667000													9	26					0	0	0.000673	0	0
LHX4	89884	broad.mit.edu	37	1	180240974	180240974	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:180240974G>A	ENST00000263726.2	+	5	855	c.611G>A	c.(610-612)tGg>tAg	p.W204*	RP5-1180C10.2_ENST00000415414.1_RNA	NM_033343.3	NP_203129.1	Q969G2	LHX4_HUMAN	LIM homeobox 4	204						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|skin(1)	16						TGGCAGGTTTGGTTTCAGAAC	0.607000													37	159					0	0	0.007835	0	0
AXIN1	8312	broad.mit.edu	37	16	360064	360064	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:360064C>T	ENST00000262320.3	-	4	1396	c.1025G>A	c.(1024-1026)gGg>gAg	p.G342E	AXIN1_ENST00000354866.3_Missense_Mutation_p.G342E|AXIN1_ENST00000481769.1_5'UTR	NM_003502.3	NP_003493.1	O15169	AXIN1_HUMAN	axin 1	342					activation of JUN kinase activity|activation of protein kinase activity|apoptosis|axial mesoderm formation|canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation|cellular protein complex assembly|cellular response to organic cyclic compound|cytoplasmic microtubule organization|determination of left/right symmetry|dorsal/ventral axis specification|embryonic eye morphogenesis|embryonic skeletal joint morphogenesis|forebrain anterior/posterior pattern formation|muscle cell development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of fat cell differentiation|olfactory placode formation|optic placode formation|positive regulation of JNK cascade|positive regulation of peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of transcription, DNA-dependent|positive regulation of ubiquitin-protein ligase activity|regulation of catenin import into nucleus|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuron fate commitment|Wnt receptor signaling pathway involved in somitogenesis	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|cell cortex|cytoplasmic membrane-bounded vesicle|cytoplasmic microtubule|cytosol|lateral plasma membrane|nucleus|perinuclear region of cytoplasm|postsynaptic density	armadillo repeat domain binding|beta-catenin binding|GTPase activator activity|I-SMAD binding|p53 binding|protein complex scaffold|protein homodimerization activity|protein kinase binding|signal transducer activity|ubiquitin protein ligase binding			biliary_tract(27)|breast(4)|central_nervous_system(6)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(20)|liver(81)|lung(5)|ovary(2)|prostate(3)|salivary_gland(7)|skin(5)|stomach(4)|thyroid(41)|upper_aerodigestive_tract(4)|urinary_tract(2)	221		all_cancers(16;2.75e-07)|all_epithelial(16;1.6e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00774)|all_lung(18;0.0187)				TGGGGGGATCCCATCCCTGTC	0.627000													7	5					0	0	0.004482	0	0
KLF17	128209	broad.mit.edu	37	1	44595349	44595349	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:44595349G>A	ENST00000372299.3	+	2	464	c.406G>A	c.(406-408)Gga>Aga	p.G136R	KLF17_ENST00000476802.1_Intron	NM_173484.3	NP_775755.3	Q5JT82	KLF17_HUMAN	Kruppel-like factor 17	136					regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|large_intestine(1)|lung(6)|ovary(3)|prostate(1)|skin(2)|stomach(1)	18	Acute lymphoblastic leukemia(166;0.155)					AATGCCCGTAGGAGAGCCCAA	0.542000													22	50					0	0	0.002299	0	0
ZNF733P	643955	broad.mit.edu	37	7	62758735	62758735	+	RNA	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:62758735G>A	ENST00000331425.6	-	0	142					NR_003952.1																						CCTCCAGAGAGAATTCTATAG	0.433000													7	76					0	0	0.001984	0	0
TGFBRAP1	9392	broad.mit.edu	37	2	105883951	105883951	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:105883951G>A	ENST00000393359.2	-	12	2898	c.2472C>T	c.(2470-2472)ccC>ccT	p.P824P	TGFBRAP1_ENST00000258449.1_Silent_p.P824P			Q8WUH2	TGFA1_HUMAN	transforming growth factor, beta receptor associated protein 1	824					regulation of transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway	cytoplasm|membrane	SMAD binding|small GTPase regulator activity|transforming growth factor beta receptor binding			central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(5)|lung(11)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	31						GCTCACAAAAGGGATTTTGGC	0.468000													34	46					0	0	0.003755	0	0
SEMA5A	9037	broad.mit.edu	37	5	9122771	9122771	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:9122771G>T	ENST00000382496.5	-	14	2443	c.1778C>A	c.(1777-1779)tCc>tAc	p.S593Y		NM_003966.2	NP_003957.2	Q13591	SEM5A_HUMAN	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A	593	TSP type-1 1.				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				biliary_tract(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(13)|lung(40)|ovary(2)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	81						GGCACACCTGGAACAGTTGGC	0.567000													16	52					1.02788e-11	1.75096e-11	0.004990	1	0
PRAMEF12	390999	broad.mit.edu	37	1	12837394	12837394	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:12837394C>T	ENST00000357726.4	+	3	1131	c.1104C>T	c.(1102-1104)atC>atT	p.I368I		NM_001080830.1	NP_001074299.1	O95522	PRA12_HUMAN	PRAME family member 12	368										NS(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(9)|ovary(3)|skin(1)|urinary_tract(1)	23	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.00143)|all_lung(284;0.00181)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00818)|Colorectal(212;5.04e-06)|Kidney(185;4.99e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000198)|COAD - Colon adenocarcinoma(227;0.000245)|BRCA - Breast invasive adenocarcinoma(304;0.000295)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCAGCGCCATCCTGCCTGCCC	0.632000													23	61					0	0	0.003954	0	0
GATA2	2624	broad.mit.edu	37	3	128204627	128204627	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:128204627C>T	ENST00000341105.2	-	3	1145	c.814G>A	c.(814-816)Ggg>Agg	p.G272R	GATA2_ENST00000430265.2_Missense_Mutation_p.G272R|GATA2_ENST00000487848.1_Missense_Mutation_p.G272R	NM_032638.4	NP_116027.2	P23769	GATA2_HUMAN	GATA binding protein 2	272					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(58)|kidney(2)|large_intestine(3)|lung(9)|prostate(3)|skin(1)|urinary_tract(1)	79				GBM - Glioblastoma multiforme(114;0.173)		GCCGGTCCCCCCAGGAAGCCT	0.642000			Mis		AML(CML blast transformation)								7	16					0	0	0.004482	0	0
C6orf223	221416	broad.mit.edu	37	6	43968718	43968718	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43968718G>A	ENST00000439969.2	+	2	92	c.89G>A	c.(88-90)aGg>aAg	p.R30K	RP5-1120P11.1_ENST00000422059.1_RNA|C6orf223_ENST00000448947.2_Intron|RP5-1120P11.1_ENST00000607590.1_RNA|C6orf223_ENST00000336600.5_Intron			Q8N319	CF223_HUMAN	chromosome 6 open reading frame 223	0										central_nervous_system(1)|lung(2)|pancreas(1)|prostate(1)|urinary_tract(1)	6	all_cancers(18;2.28e-07)|all_epithelial(2;1.62e-08)|Lung NSC(15;0.000172)|all_lung(25;0.000533)|Hepatocellular(11;0.00309)|Ovarian(13;0.0437)		all cancers(41;0.00141)|Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.217)			AAGTTGTTGAGGAAGGAGGGA	0.567000													10	58					0	0	0.000978	0	0
SNHG14	104472715	broad.mit.edu	37	15	25463749	25463749	+	RNA	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:25463749G>A	ENST00000424208.1	+	0	2994				SNHG14_ENST00000453082.2_RNA	NR_003305.1																						TGCGGGAAGGGGGGTGCCCTG	0.547000													50	23					0	0	0.003610	0	0
HLX	3142	broad.mit.edu	37	1	221057631	221057631	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:221057631C>T	ENST00000366903.6	+	4	2553	c.1052C>T	c.(1051-1053)cCa>cTa	p.P351L	HLX_ENST00000549319.1_Missense_Mutation_p.P137L	NM_021958.3	NP_068777.1	Q14774	HLX_HUMAN	H2.0-like homeobox	351					cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|endometrium(5)|large_intestine(9)|lung(11)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	32				GBM - Glioblastoma multiforme(131;0.00914)		GGCGAGAAGCCATCAGGTGGA	0.657000													46	23					0	0	0.003610	0	0
DSP	1832	broad.mit.edu	37	6	7584736	7584736	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:7584736G>T	ENST00000379802.3	+	24	7582	c.7241G>T	c.(7240-7242)gGa>gTa	p.G2414V	DSP_ENST00000418664.2_Missense_Mutation_p.G1815V	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2414	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GATACCAAAGGATTTTTTGAC	0.408000													35	134					1.06647e-15	1.82064e-15	0.003755	1	0
HNRNPL	3191	broad.mit.edu	37	19	39329542	39329542	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:39329542C>T	ENST00000221419.5	-	9	1713	c.1347G>A	c.(1345-1347)ctG>ctA	p.L449L	AC104534.3_ENST00000594769.1_Silent_p.*66*|HNRNPL_ENST00000600873.1_Silent_p.L316L	NM_001533.2	NP_001524.2	P14866	HNRPL_HUMAN	heterogeneous nuclear ribonucleoprotein L	449	RRM 3.				nuclear mRNA splicing, via spliceosome	cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	nucleotide binding|protein binding|RNA binding|transcription regulatory region DNA binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(10)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	30	all_cancers(60;6.83e-06)|Ovarian(47;0.0454)		Lung(45;0.00342)|LUSC - Lung squamous cell carcinoma(53;0.00575)			ACCAGACATTCAGCTTCTGCC	0.597000													33	47					0	0	0.004878	0	0
B4GALT7	11285	broad.mit.edu	37	5	177031345	177031345	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:177031345C>T	ENST00000029410.5	+	2	327	c.216C>T	c.(214-216)ccC>ccT	p.P72P		NM_007255.2	NP_009186.1	Q9UBV7	B4GT7_HUMAN	xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7	72					fibril organization|glycosaminoglycan biosynthetic process|negative regulation of fibroblast proliferation|protein modification process|proteoglycan metabolic process	Golgi cisterna membrane|integral to membrane	metal ion binding|xylosylprotein 4-beta-galactosyltransferase activity			endometrium(2)|large_intestine(1)|lung(1)|pancreas(1)|skin(1)|urinary_tract(1)	7	all_cancers(89;0.00033)|Renal(175;0.000269)|Lung NSC(126;0.00161)|all_lung(126;0.00286)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CGGGCCCTCCCCGTGCCTGCC	0.701000													4	6					0	0	0.000248	0	0
ZNF14	7561	broad.mit.edu	37	19	19822584	19822584	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:19822584G>A	ENST00000344099.3	-	4	1644	c.1506C>T	c.(1504-1506)ccC>ccT	p.P502P		NM_021030.2	NP_066358.2	P17017	ZNF14_HUMAN	zinc finger protein 14	502					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|cervix(2)|endometrium(1)|large_intestine(9)|lung(8)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(3)	32		Renal(1328;0.0474)				TACATTCATAGGGTTTCTCTC	0.383000													25	38					0	0	0.003954	0	0
DEFB125	245938	broad.mit.edu	37	20	76862	76862	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:76862C>T	ENST00000382410.2	+	2	275	c.275C>T	c.(274-276)cCa>cTa	p.P92L		NM_153325.2	NP_697020.2	Q8N687	DB125_HUMAN	defensin, beta 125	92					defense response to bacterium	extracellular region				central_nervous_system(1)|large_intestine(1)|lung(7)|ovary(1)|skin(2)	12		all_cancers(10;7.65e-05)|Lung NSC(37;0.0417)|all_epithelial(17;0.0676)|all_lung(30;0.0713)|Breast(17;0.231)	OV - Ovarian serous cystadenocarcinoma(29;0.156)			ACTGGTTCCCCAGTATCTATG	0.383000													27	143					0	0	0.004656	0	0
EHMT2	10919	broad.mit.edu	37	6	31860664	31860664	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31860664G>A	ENST00000395728.3	-	4	776	c.777C>T	c.(775-777)ccC>ccT	p.P259P	EHMT2_ENST00000375528.4_Silent_p.P259P|EHMT2_ENST00000480912.1_5'UTR|EHMT2_ENST00000375537.4_Silent_p.P202P|EHMT2_ENST00000375530.4_Silent_p.P202P			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	202					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						GTATTTCAGGGGGCCGCTTCT	0.617000													98	812					0	0	0.003610	0	0
TMC1	117531	broad.mit.edu	37	9	75404142	75404142	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:75404142G>A	ENST00000297784.5	+	15	1673	c.1133G>A	c.(1132-1134)gGg>gAg	p.G378E	TMC1_ENST00000396237.3_Missense_Mutation_p.G378E|TMC1_ENST00000340019.3_Missense_Mutation_p.G378E	NM_138691.2	NP_619636.2	Q8TDI8	TMC1_HUMAN	transmembrane channel-like 1	378					sensory perception of sound	integral to membrane				NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(21)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	36						ACACTTGGAGGGAGTGGATAC	0.463000													21	41					0	0	0.001216	0	0
TMEM260	54916	broad.mit.edu	37	14	57099831	57099831	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:57099831C>T	ENST00000261556.6	+	13	1788	c.1666C>T	c.(1666-1668)Cct>Tct	p.P556S	TMEM260_ENST00000536419.1_Missense_Mutation_p.P90S|TMEM260_ENST00000538838.1_3'UTR	NM_017799.3	NP_060269.3			transmembrane protein 260																		TGTATTCAACCCTGAGGAATG	0.383000													13	32					0	0	0.004990	0	0
LHFPL5	222662	broad.mit.edu	37	6	35773696	35773696	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:35773696C>T	ENST00000360215.1	+	1	626	c.249C>T	c.(247-249)ccC>ccT	p.P83P	LHFPL5_ENST00000373853.1_Silent_p.P83P	NM_182548.3	NP_872354.1	Q8TAF8	TMHS_HUMAN	lipoma HMGIC fusion partner-like 5	83						integral to membrane				endometrium(4)|large_intestine(4)|lung(7)|prostate(2)|skin(2)|urinary_tract(1)	20						AGGGCGGCCCCCTAGACTTCT	0.577000													46	249					0	0	0.003610	0	0
PHOX2B	8929	broad.mit.edu	37	4	41750415	41750415	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:41750415C>T	ENST00000226382.2	-	1	572	c.213G>A	c.(211-213)agG>agA	p.R71R	RP11-227F19.1_ENST00000508038.1_RNA	NM_003924.3	NP_003915.2	Q99453	PHX2B_HUMAN	paired-like homeobox 2b	71					positive regulation of transcription from RNA polymerase II promoter	nuclear chromatin	RNA polymerase II regulatory region sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			autonomic_ganglia(7)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(11)|ovary(2)|skin(1)|urinary_tract(1)	30						TCTGGTGGTCCCTGAGGGTGC	0.602000			"""Mis, F"""		neuroblastoma	neuroblastoma	congenital central hypoventilation syndrome		Neuroblastoma, Familial Clustering of;Congenital Central Hypoventilation Syndrome				9	84					0	0	0.000673	0	0
C4A	720	broad.mit.edu	37	6	31964370	31964370	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31964370G>A	ENST00000428956.2	+	28	3753	c.3669G>A	c.(3667-3669)gaG>gaA	p.E1223E	C4A_ENST00000498271.1_Silent_p.E1223E	NM_007293.2	NP_009224.2			complement component 4A (Rodgers blood group)																		TGGCCCAGGAGACTGGAGGTG	0.637000													11	154					0	0	0.001855	0	0
BACH2	60468	broad.mit.edu	37	6	90660621	90660621	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:90660621C>T	ENST00000257749.4	-	7	1911	c.1204G>A	c.(1204-1206)Gtg>Atg	p.V402M	BACH2_ENST00000343122.3_Missense_Mutation_p.V402M|RP3-512E2.2_ENST00000413986.1_RNA|BACH2_ENST00000537989.1_Missense_Mutation_p.V402M|RP3-512E2.2_ENST00000445838.1_RNA	NM_021813.2	NP_068585.1	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper transcription factor 2	402						nucleus	protein dimerization activity|sequence-specific DNA binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(18)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	45		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		AAGTTGGACACCTCCTTCTGG	0.582000													17	19					0	0	0.007413	0	0
KCNH2	3757	broad.mit.edu	37	7	150648756	150648756	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:150648756C>T	ENST00000392968.2	-	5	2557	c.1437G>A	c.(1435-1437)gaG>gaA	p.E479E	KCNH2_ENST00000430723.3_Silent_p.E575E|KCNH2_ENST00000262186.5_Silent_p.E575E|KCNH2_ENST00000330883.4_Silent_p.E235E			Q12809	KCNH2_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 2	575					blood circulation|muscle contraction|regulation of heart contraction|regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|two-component sensor activity			NS(1)|cervix(1)|endometrium(10)|kidney(1)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(6)|upper_aerodigestive_tract(1)	42	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiodarone(DB01118)|Amsacrine(DB00276)|Astemizole(DB00637)|Carvedilol(DB01136)|Cisapride(DB00604)|Dofetilide(DB00204)|Halofantrine(DB01218)|Ibutilide(DB00308)|Pimozide(DB01100)|Propafenone(DB01182)|Quinidine(DB00908)|Sertindole(DB06144)|Sotalol(DB00489)|Terfenadine(DB00342)|Verapamil(DB00661)	TGTGTGGCTGCTCCATGTTGC	0.622000													21	17					0	0	0.002299	0	0
GPR31	2853	broad.mit.edu	37	6	167570376	167570376	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:167570376C>T	ENST00000366834.1	-	1	1441	c.944G>A	c.(943-945)aGa>aAa	p.R315K		NM_005299.2	NP_005290.2	O00270	GPR31_HUMAN	G protein-coupled receptor 31	315						integral to plasma membrane	G-protein coupled receptor activity			NS(1)|endometrium(4)|large_intestine(4)|lung(7)|prostate(1)	17		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;4.81e-20)|BRCA - Breast invasive adenocarcinoma(81;4.45e-06)|GBM - Glioblastoma multiforme(31;0.00492)		ATAGGAGTCTCTGGGGTTGAA	0.537000													12	19					0	0	0.002450	0	0
CCDC157	550631	broad.mit.edu	37	22	30766447	30766447	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:30766447C>T	ENST00000405659.1	+	5	1262	c.553C>T	c.(553-555)Caa>Taa	p.Q185*	CCDC157_ENST00000338306.3_Nonsense_Mutation_p.Q185*			Q569K6	CC157_HUMAN	coiled-coil domain containing 157	185										central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(5)|skin(3)|upper_aerodigestive_tract(1)	15						CCAGACCTGCCAAGAGCCAGA	0.597000													30	8					0	0	0.001786	0	0
C3orf20	84077	broad.mit.edu	37	3	14745926	14745926	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:14745926C>T	ENST00000253697.3	+	7	1413	c.961C>T	c.(961-963)Cat>Tat	p.H321Y	C3orf20_ENST00000412910.1_Missense_Mutation_p.H199Y|C3orf20_ENST00000435614.1_Missense_Mutation_p.H199Y|C3orf20_ENST00000495387.1_3'UTR	NM_032137.4	NP_115513.4	Q8ND61	CC020_HUMAN	chromosome 3 open reading frame 20	321						cytoplasm|integral to membrane				NS(1)|breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(13)|lung(11)|ovary(4)|skin(2)	40						GATGCCCTCTCATCTAATGTT	0.527000													36	84					0	0	0.004289	0	0
NCOA6	23054	broad.mit.edu	37	20	33345250	33345250	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:33345250G>A	ENST00000374796.2	-	8	3871	c.1301C>T	c.(1300-1302)tCc>tTc	p.S434F	NCOA6_ENST00000359003.2_Missense_Mutation_p.S434F			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	434	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						CTGCTGGAAGGAGGAGGGTGA	0.582000													16	62					0	0	0.003163	0	0
MUC16	94025	broad.mit.edu	37	19	9077817	9077817	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9077817C>T	ENST00000397910.4	-	3	9832	c.9629G>A	c.(9628-9630)aGc>aAc	p.S3210N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3211	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TTCCTTGGAGCTCATGATTTT	0.468000													55	55					0	0	0.003610	0	0
SEC31B	25956	broad.mit.edu	37	10	102266174	102266174	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:102266174C>T	ENST00000370345.3	-	8	883	c.786G>A	c.(784-786)ggG>ggA	p.G262G	SEC31B_ENST00000451524.1_Silent_p.G262G|SEC31B_ENST00000370329.5_Silent_p.G265G|SEC31B_ENST00000535773.1_Silent_p.G105G	NM_015490.3	NP_056305.1	Q9NQW1	SC31B_HUMAN	SEC31 homolog B (S. cerevisiae)	262					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				NS(1)|breast(2)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(3)|lung(17)|ovary(1)|urinary_tract(1)	36		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		CTGACAAGATCCCCCTAAAAA	0.473000													13	19					0	0	0.001855	0	0
GSE1	23199	broad.mit.edu	37	16	85694854	85694854	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:85694854C>T	ENST00000253458.7	+	9	1919	c.1743C>T	c.(1741-1743)ccC>ccT	p.P581P	GSE1_ENST00000405402.2_Silent_p.P477P|GSE1_ENST00000393243.1_Silent_p.P508P	NM_014615.2	NP_055430.1			Gse1 coiled-coil protein																		ATGCTGCACCCACGGCCCTCT	0.657000													23	45					0	0	0.002780	0	0
TANC2	26115	broad.mit.edu	37	17	61466735	61466735	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:61466735C>T	ENST00000424789.2	+	15	2663	c.2659C>T	c.(2659-2661)Cca>Tca	p.P887S	TANC2_ENST00000389520.4_Missense_Mutation_p.P887S|AC015923.1_ENST00000431604.1_RNA	NM_025185.3	NP_079461.2	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2	887							binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|upper_aerodigestive_tract(3)	44						AAATAATGCTCCAATTCTATG	0.443000													37	50					0	0	0.003214	0	0
LSM14B	149986	broad.mit.edu	37	20	60701364	60701364	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:60701364C>T	ENST00000253001.4	+	3	502	c.296C>T	c.(295-297)tCc>tTc	p.S99F	LSM14B_ENST00000279068.6_Missense_Mutation_p.S99F|LSM14B_ENST00000370915.1_Missense_Mutation_p.S99F			Q9BX40	LS14B_HUMAN	LSM14B, SCD6 homolog B (S. cerevisiae)	99					multicellular organismal development|regulation of translation	ribonucleoprotein complex				endometrium(3)|kidney(1)|lung(4)	8	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			GTTCAGTCTTCCCTGGGTTCT	0.652000													10	23					0	0	0.001368	0	0
TTC4	7268	broad.mit.edu	37	1	55197279	55197279	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:55197279C>T	ENST00000371281.3	+	7	889	c.802C>T	c.(802-804)Cta>Tta	p.L268L	TTC4_ENST00000371284.5_3'UTR|MROH7_ENST00000414150.2_3'UTR	NM_004623.4	NP_004614.3	O95801	TTC4_HUMAN	tetratricopeptide repeat domain 4	268							binding			breast(2)|endometrium(3)|kidney(1)|lung(2)|stomach(1)	9						CAGGCTGAGTCTAGATGGCCA	0.547000													14	17					0	0	0.002450	0	0
MDN1	23195	broad.mit.edu	37	6	90397860	90397860	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:90397860G>A	ENST00000369393.3	-	67	11407	c.11292C>T	c.(11290-11292)ttC>ttT	p.F3764F	MDN1_ENST00000428876.1_Silent_p.F3764F			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	3764					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TGGAAAGTGGGAAACTACGAA	0.443000													89	99					0	0	0.003610	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43937379	43937379	+	Silent	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:43937379T>G	ENST00000282406.4	+	13	2234	c.2124T>G	c.(2122-2124)ggT>ggG	p.G708G		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	708	PH 1.					cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AAAAATCTGGTTATTTATTAA	0.353000													130	249					0	0	0.003610	0	0
ZFHX4	79776	broad.mit.edu	37	8	77617776	77617776	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:77617776G>A	ENST00000521891.2	+	2	1901	c.1453G>A	c.(1453-1455)Gag>Aag	p.E485K	ZFHX4_ENST00000050961.6_Missense_Mutation_p.E485K|ZFHX4_ENST00000517683.1_Intron|ZFHX4_ENST00000455469.2_Missense_Mutation_p.E485K|ZFHX4_ENST00000518282.1_Missense_Mutation_p.E485K	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	485						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ACTTGATGACGAGGAAGTATT	0.423000										HNSCC(33;0.089)			9	33					0	0	0.004482	0	0
CD101	9398	broad.mit.edu	37	1	117568166	117568166	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:117568166G>A	ENST00000256652.4	+	8	2522	c.2464G>A	c.(2464-2466)Gaa>Aaa	p.E822K	CD101_ENST00000369470.1_Missense_Mutation_p.E822K|RP11-27K13.3_ENST00000445523.1_RNA	NM_001256106.1|NM_001256109.1|NM_001256111.1|NM_004258.4	NP_001243035.1|NP_001243038.1|NP_001243040.1|NP_004249.2	Q93033	IGSF2_HUMAN	CD101 molecule	822	Ig-like C2-type 7.				cell surface receptor linked signaling pathway	integral to membrane|plasma membrane	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			NS(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(14)|lung(18)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	49						GTACTGGACCGAAAATGTGAC	0.463000													28	54					0	0	0.004289	0	0
ATF6B	1388	broad.mit.edu	37	6	32087714	32087714	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32087714G>A	ENST00000375201.4	-	9	889	c.844C>T	c.(844-846)Cag>Tag	p.Q282*	ATF6B_ENST00000375203.3_Nonsense_Mutation_p.Q285*			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	285					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						ATAGCACCCTGGATGAGGACA	0.622000													192	534					0	0	0.003610	0	0
SELE	6401	broad.mit.edu	37	1	169697262	169697262	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:169697262C>T	ENST00000333360.7	-	8	1355	c.1216G>A	c.(1216-1218)Gga>Aga	p.G406R	SELE_ENST00000367776.1_Intron|SELE_ENST00000367780.4_Intron|SELE_ENST00000367781.4_Intron|SELE_ENST00000367779.4_Intron|SELE_ENST00000367774.1_Intron|C1orf112_ENST00000498289.1_Intron|SELE_ENST00000367782.4_Missense_Mutation_p.G406R|SELE_ENST00000367777.1_Missense_Mutation_p.G406R|SELE_ENST00000367775.1_Intron	NM_000450.2	NP_000441.2	P16581	LYAM2_HUMAN	selectin E	406	Sushi 4.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			breast(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|ovary(3)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	32	all_hematologic(923;0.208)					CTTTTGGATCCCTTCAACACA	0.473000													40	147					0	0	0.007835	0	0
MFSD6L	162387	broad.mit.edu	37	17	8702206	8702206	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:8702206G>A	ENST00000329805.4	-	1	461	c.233C>T	c.(232-234)gCg>gTg	p.A78V		NM_152599.3	NP_689812.3	Q8IWD5	MFS6L_HUMAN	major facilitator superfamily domain containing 6-like	78						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(1)|lung(7)|skin(4)	17						GATCAGAAGCGCTCTCCTTTT	0.612000													24	28					0	0	0.003330	0	0
FBXO46	23403	broad.mit.edu	37	19	46216473	46216473	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:46216473G>A	ENST00000317683.3	-	2	414	c.281C>T	c.(280-282)cCc>cTc	p.P94L		NM_001080469.1	NP_001073938.1	Q6PJ61	FBX46_HUMAN	F-box protein 46	94							protein binding			breast(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(6)|ovary(2)|skin(1)	15		Ovarian(192;0.179)|all_neural(266;0.224)		OV - Ovarian serous cystadenocarcinoma(262;0.00568)|GBM - Glioblastoma multiforme(486;0.0844)|Epithelial(262;0.201)		TGTATTCCCGGGCTTGATGAC	0.637000													17	41					0	0	0.001882	0	0
RFC1	5981	broad.mit.edu	37	4	39304682	39304682	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:39304682G>A	ENST00000381897.1	-	16	2336	c.2203C>T	c.(2203-2205)Cag>Tag	p.Q735*	RFC1_ENST00000349703.2_Nonsense_Mutation_p.Q734*	NM_001204747.1|NM_002913.4	NP_001191676.1|NP_002904.3	P35251	RFC1_HUMAN	replication factor C (activator 1) 1, 145kDa	735					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			haematopoietic_and_lymphoid_tissue(2)|large_intestine(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	16						TGAATTACCTGAATTCCTCCC	0.428000													27	143					0	0	0.007291	0	0
IP6K1	9807	broad.mit.edu	37	3	49775748	49775748	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:49775748C>G	ENST00000321599.4	-	3	632	c.331G>C	c.(331-333)Gag>Cag	p.E111Q	IP6K1_ENST00000460540.1_5'UTR|IP6K1_ENST00000395238.1_5'UTR|IP6K1_ENST00000468463.1_Missense_Mutation_p.E111Q	NM_001242829.1|NM_153273.3	NP_001229758.1|NP_695005.1	Q92551	IP6K1_HUMAN	inositol hexakisphosphate kinase 1	111					phosphatidylinositol phosphorylation	cytoplasm|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(2)|skin(2)	15						CGAGGTTGCTCCCGTTCTGTT	0.547000													19	64					0	0	0.007413	0	0
RRP1B	23076	broad.mit.edu	37	21	45094543	45094543	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:45094543C>T	ENST00000340648.4	+	5	501	c.384C>T	c.(382-384)tcC>tcT	p.S128S		NM_015056.2	NP_055871.1	Q14684	RRP1B_HUMAN	ribosomal RNA processing 1B	128					rRNA processing	cytosol|nucleolus|preribosome, small subunit precursor	protein binding			cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(3)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|stomach(1)	21				STAD - Stomach adenocarcinoma(101;0.178)		TGAGGCAGTCCTTTGAAGTCT	0.343000													10	16					0	0	0.002450	0	0
KLHDC7B	113730	broad.mit.edu	37	22	50987593	50987593	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:50987593G>A	ENST00000395676.2	+	1	1132	c.998G>A	c.(997-999)cGg>cAg	p.R333Q		NM_138433.3	NP_612442.2	Q96G42	KLD7B_HUMAN	kelch domain containing 7B	333										central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	14		all_cancers(38;1.53e-10)|all_epithelial(38;1.82e-09)|Breast(42;0.000448)|all_lung(38;0.000665)|Lung NSC(38;0.0104)|Ovarian(80;0.104)|Lung SC(80;0.162)|Hepatocellular(38;0.178)		OV - Ovarian serous cystadenocarcinoma(4;7.49e-69)|all cancers(3;9.79e-66)|Epithelial(4;1.3e-63)|GBM - Glioblastoma multiforme(4;0.000399)|Lung(4;0.125)|BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		AACACCTGGCGGCCCCTGACC	0.706000													18	58					0	0	0.006122	0	0
LRRC34	151827	broad.mit.edu	37	3	169511529	169511529	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:169511529G>A	ENST00000522526.2	-	10	1630	c.1193C>T	c.(1192-1194)tCc>tTc	p.S398F	LRRC34_ENST00000522830.1_Missense_Mutation_p.S369F|LRRC34_ENST00000316515.7_Missense_Mutation_p.S385F|LRRC34_ENST00000446859.1_Missense_Mutation_p.S430F|RP11-362K14.7_ENST00000602913.1_RNA			Q8IZ02	LRC34_HUMAN	leucine rich repeat containing 34	385										breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|upper_aerodigestive_tract(2)	10	all_cancers(22;4.12e-22)|all_epithelial(15;7.54e-27)|all_lung(20;1.63e-16)|Lung NSC(18;6.92e-16)|Ovarian(172;0.000223)|Breast(254;0.197)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.00676)			AAGGCCATTGGAGACTTCTGC	0.388000													22	46					0	0	0.001882	0	0
DHX16	8449	broad.mit.edu	37	6	30633412	30633412	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:30633412G>A	ENST00000376442.3	-	5	960	c.765C>T	c.(763-765)ttC>ttT	p.F255F		NM_001164239.1|NM_003587.4	NP_001157711.1|NP_003578.2	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	255					mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity	p.F255F(1)		kidney(2)|ovary(2)	4						CCCCAAAAAGGAACTCCTCAT	0.632000													13	117					0	0	0.001855	0	0
OR52B2	255725	broad.mit.edu	37	11	6191512	6191512	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:6191512G>A	ENST00000530810.1	-	1	126	c.45C>T	c.(43-45)gtC>gtT	p.V15V	RP11-290F24.3_ENST00000529961.1_RNA	NM_001004052.1	NP_001004052.1	Q96RD2	O52B2_HUMAN	olfactory receptor, family 52, subfamily B, member 2	15					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(3)|endometrium(1)|large_intestine(1)|lung(15)	21		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;3.69e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGCCAGGAAGGACAAAAACTG	0.448000													14	23					0	0	0.002450	0	0
SHANK2	22941	broad.mit.edu	37	11	70336491	70336491	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:70336491G>A	ENST00000338508.4	-	30	2443	c.2442_splice	c.e30-1	p.S815_splice	SHANK2_ENST00000409530.1_Splice_Site_p.S225_splice|SHANK2_ENST00000449833.2_Splice_Site_p.S219_splice|SHANK2_ENST00000423696.2_Splice_Site_p.S435_splice|SHANK2_ENST00000449116.2_Splice_Site_p.S216_splice|SHANK2_ENST00000357171.3_Splice_Site_p.S226_splice|SHANK2_ENST00000409161.1_Splice_Site_p.S218_splice			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	435					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TTCGTACACAGACTGCAAACC	0.622000													26	271					0	0	0.001512	0	0
PCDH18	54510	broad.mit.edu	37	4	138442737	138442737	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:138442737C>T	ENST00000344876.4	-	4	3240	c.2854G>A	c.(2854-2856)Gaa>Aaa	p.E952K	PCDH18_ENST00000510305.1_Missense_Mutation_p.E163K|PCDH18_ENST00000507846.1_Missense_Mutation_p.E731K|PCDH18_ENST00000412923.2_Missense_Mutation_p.E951K|PCDH18_ENST00000511115.1_Missense_Mutation_p.E132K	NM_019035.3	NP_061908.1	Q9HCL0	PCD18_HUMAN	protocadherin 18	952	Interaction with DAB1 (By similarity).				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(27)|lung(21)|ovary(2)|pancreas(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	86	all_hematologic(180;0.24)					GGGAATTCTTCCCCTGGAATG	0.532000													41	53					0	0	0.007835	0	0
BZRAP1	9256	broad.mit.edu	37	17	56388315	56388315	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:56388315G>A	ENST00000355701.3	-	19	4211	c.3341C>T	c.(3340-3342)tCt>tTt	p.S1114F	BZRAP1_ENST00000343736.4_Missense_Mutation_p.S1114F|BZRAP1_ENST00000268893.6_Missense_Mutation_p.S1054F	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1114	Pro-rich.					mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CTGGAGAGGAGAGCTGGGGTC	0.672000													15	13					0	0	0.004990	0	0
SYT10	341359	broad.mit.edu	37	12	33579230	33579230	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:33579230C>T	ENST00000228567.3	-	2	648	c.352G>A	c.(352-354)Gaa>Aaa	p.E118K	SYT10_ENST00000535526.1_5'UTR	NM_198992.3	NP_945343.1	Q6XYQ8	SYT10_HUMAN	synaptotagmin X	118						cell junction|integral to membrane|synaptic vesicle membrane	metal ion binding|transporter activity			NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(18)|ovary(1)|prostate(3)|skin(4)|urinary_tract(1)	42	Lung NSC(5;8.37e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0334)					TTTTCATTTTCCTTAATTTCT	0.408000													40	190					0	0	0.006230	0	0
RTP4	64108	broad.mit.edu	37	3	187088772	187088772	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:187088772C>T	ENST00000259030.2	+	2	462	c.352C>T	c.(352-354)Ctg>Ttg	p.L118L		NM_022147.2	NP_071430.2	Q96DX8	RTP4_HUMAN	receptor (chemosensory) transporter protein 4	118					detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(5)|skin(1)	11	all_cancers(143;4.66e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.56e-18)	GBM - Glioblastoma multiforme(93;0.0269)		TCTGAGCAACCTGGTGCAGCA	0.502000													8	29					0	0	0.004482	0	0
OR11A1	26531	broad.mit.edu	37	6	29395052	29395052	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:29395052G>A	ENST00000377149.1	-	5	839	c.367C>T	c.(367-369)Cgc>Tgc	p.R123C	OR5V1_ENST00000377154.1_Intron|OR11A1_ENST00000377148.1_Missense_Mutation_p.R123C|OR11A1_ENST00000377147.2_Missense_Mutation_p.R123C			Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A, member 1	123					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|large_intestine(1)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	19						GCCAGGTAGCGGTCATATGCC	0.537000													17	145					0	0	0.004007	0	0
HCP5	10866	broad.mit.edu	37	6	31431899	31431899	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31431899C>T	ENST00000414046.2	+	0	971					NR_040662.1		Q6MZN7	HCP5_HUMAN							defense response					urinary_tract(1)	1						gtgcaaaatcccacgacaggt	0.488000													17	117					0	0	0.006122	0	0
FLG2	388698	broad.mit.edu	37	1	152324872	152324872	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:152324872C>T	ENST00000388718.5	-	3	5462	c.5390G>A	c.(5389-5391)gGa>gAa	p.G1797E	FLG-AS1_ENST00000445097.1_RNA|FLG-AS1_ENST00000392688.2_RNA	NM_001014342.2	NP_001014364.1	Q5D862	FILA2_HUMAN	filaggrin family member 2	1797							calcium ion binding|structural molecule activity			NS(2)|breast(7)|cervix(3)|endometrium(11)|kidney(9)|large_intestine(24)|liver(1)|lung(85)|ovary(12)|pancreas(1)|prostate(6)|skin(17)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(5)	188	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACCTTCTTCCAGTGGTCCT	0.547000													52	181					0	0	0.003610	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3678675	3678675	+	Missense_Mutation	SNP	G	G	A	rs143548718		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:3678675G>A	ENST00000344754.4	-	8	1891	c.1892C>T	c.(1891-1893)cCc>cTc	p.P631L	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.P631L	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	631	Ig-like C2-type 6.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						CAGCCTGGCGGGGGGGTCGCT	0.667000													8	17					0	0	0.003080	0	0
TNXB	7148	broad.mit.edu	37	6	32053871	32053871	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32053871C>T	ENST00000375244.3	-	7	3005	c.2804G>A	c.(2803-2805)gGg>gAg	p.G935E	TNXB_ENST00000375247.2_Missense_Mutation_p.G935E			P22105	TENX_HUMAN	tenascin XB	1028					actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						ATCGGTAGTCCCCAAGAGGCC	0.627000													34	393					0	0	0.006230	0	0
ARSK	153642	broad.mit.edu	37	5	94936653	94936653	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:94936653C>T	ENST00000380009.4	+	7	1404	c.1199C>T	c.(1198-1200)cCa>cTa	p.P400L		NM_198150.2	NP_937793.1	Q6UWY0	ARSK_HUMAN	arylsulfatase family, member K	400						extracellular region	arylsulfatase activity|metal ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(1)	16		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		AACCTGCATCCACCCTGGATT	0.418000													76	118					0	0	0.003610	0	0
INTS1	26173	broad.mit.edu	37	7	1522326	1522326	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:1522326G>A	ENST00000389470.4	-	28	4044	c.4045C>T	c.(4045-4047)Cag>Tag	p.Q1349*	INTS1_ENST00000404767.3_Nonsense_Mutation_p.Q1187*			Q8N201	INT1_HUMAN	integrator complex subunit 1	1187					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		AGCAGCGCCTGGAACTCGCTG	0.647000													26	251					0	0	0.007291	0	0
OR2J2	26707	broad.mit.edu	37	6	29141649	29141649	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:29141649C>T	ENST00000377167.2	+	1	339	c.237C>T	c.(235-237)atC>atT	p.I79I		NM_030905.2	NP_112167.2	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J, member 2	79					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(17)|ovary(1)|upper_aerodigestive_tract(1)	25						CCAGCTCTATCCCTCAGTTGC	0.483000													43	251					0	0	0.007835	0	0
CACUL1	143384	broad.mit.edu	37	10	120450808	120450808	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:120450808G>A	ENST00000369151.3	-	7	1477	c.994C>T	c.(994-996)Caa>Taa	p.Q332*	CACUL1_ENST00000544392.1_5'UTR	NM_153810.4	NP_722517.3			CDK2-associated, cullin domain 1																		AGTTCTCTTTGAAATTTCTGA	0.388000													71	94					0	0	0.003610	0	0
TGM7	116179	broad.mit.edu	37	15	43574782	43574782	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:43574782C>T	ENST00000452443.2	-	8	1045	c.1041G>A	c.(1039-1041)cgG>cgA	p.R347R		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	347					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	GGAGATCTTTCCGGATCATCC	0.557000													6	3					0	0	0.003080	0	0
XIRP2	129446	broad.mit.edu	37	2	168100111	168100111	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:168100111G>A	ENST00000409195.1	+	9	2298	c.2209G>A	c.(2209-2211)Gaa>Aaa	p.E737K	XIRP2_ENST00000295237.9_Missense_Mutation_p.E737K|XIRP2_ENST00000409273.1_Missense_Mutation_p.E515K|XIRP2_ENST00000409728.1_Intron|XIRP2_ENST00000409605.1_Intron|XIRP2_ENST00000409756.2_Intron|XIRP2_ENST00000420519.1_Intron|XIRP2_ENST00000409043.1_Intron	NM_152381.5	NP_689594.4	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2	562					actin cytoskeleton organization	cell junction	actin binding			NS(3)|biliary_tract(2)|breast(5)|cervix(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(51)|lung(160)|ovary(7)|pancreas(3)|prostate(11)|skin(14)|stomach(5)|upper_aerodigestive_tract(8)|urinary_tract(7)	315						AAAATGTTTCGAAACTCAACC	0.373000													13	19					0	0	0.002450	0	0
AFF3	3899	broad.mit.edu	37	2	100167981	100167981	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:100167981G>A	ENST00000317233.4	-	24	3871	c.3636C>T	c.(3634-3636)tcC>tcT	p.S1212S	AFF3_ENST00000356421.2_Silent_p.S1237S|AFF3_ENST00000409236.1_Silent_p.S1212S|AFF3_ENST00000409579.1_Silent_p.S1237S	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	1212					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						GGCCCTGTTGGGAGTACTGGA	0.592000													10	17					0	0	0.000673	0	0
COL6A3	1293	broad.mit.edu	37	2	238296801	238296801	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:238296801G>A	ENST00000295550.4	-	4	1188	c.736C>T	c.(736-738)Ctt>Ttt	p.L246F	COL6A3_ENST00000347401.3_Intron|COL6A3_ENST00000346358.4_Missense_Mutation_p.L246F|COL6A3_ENST00000472056.1_Intron|COL6A3_ENST00000353578.4_Missense_Mutation_p.L40F|COL6A3_ENST00000392003.2_Intron|COL6A3_ENST00000409809.1_Missense_Mutation_p.L40F|COL6A3_ENST00000392004.3_Missense_Mutation_p.L40F	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	246	Nonhelical region.|VWFA 2.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CCATCAATAAGGAAAATAATG	0.378000													17	32					0	0	0.001216	0	0
SLC11A2	4891	broad.mit.edu	37	12	51384698	51384698	+	Silent	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:51384698A>G	ENST00000394904.3	-	15	1591	c.1542T>C	c.(1540-1542)ctT>ctC	p.L514L	SLC11A2_ENST00000546743.1_Silent_p.L406L|SLC11A2_ENST00000545993.2_Silent_p.L481L|SLC11A2_ENST00000541174.2_Silent_p.L485L|SLC11A2_ENST00000547688.1_Silent_p.L514L|SLC11A2_ENST00000547198.1_Silent_p.L485L|SLC11A2_ENST00000262052.5_Silent_p.L485L|SLC11A2_ENST00000262051.7_Silent_p.L485L	NM_001174125.1	NP_001167596.1	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2	485					activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			breast(2)|cervix(1)|endometrium(3)|kidney(16)|large_intestine(4)|lung(9)|upper_aerodigestive_tract(1)	36						AACAGATGATAAGGACCAAGA	0.463000													12	27					0	0	0.001855	0	0
TMEM225	338661	broad.mit.edu	37	11	123753985	123753985	+	Missense_Mutation	SNP	C	C	T	rs77654932	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:123753985C>T	ENST00000375026.2	-	4	754	c.538G>A	c.(538-540)Gaa>Aaa	p.E180K		NM_001013743.1	NP_001013765.1	Q6GV28	TM225_HUMAN	transmembrane protein 225	180						integral to membrane		p.E180K(1)		endometrium(2)|kidney(2)|large_intestine(2)|lung(12)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)	28						TCCTTACATTCGTTGTCAGAT	0.443000													33	4					0	0	0.003755	0	0
PDS5A	23244	broad.mit.edu	37	4	39929628	39929628	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:39929628G>A	ENST00000303538.8	-	3	834	c.295C>T	c.(295-297)Cgt>Tgt	p.R99C	PDS5A_ENST00000503396.1_Missense_Mutation_p.R99C	NM_001100399.1	NP_001093869.1	Q29RF7	PDS5A_HUMAN	PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)	99					cell division|mitosis|negative regulation of DNA replication	chromatin|nucleus	identical protein binding			breast(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(14)|prostate(3)|skin(1)|urinary_tract(1)	39						GCATAGATACGAAAGATATCA	0.398000													15	99					0	0	0.003163	0	0
AMDHD2	51005	broad.mit.edu	37	16	2578376	2578376	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:2578376C>T	ENST00000302956.4	+	7	951	c.857C>T	c.(856-858)cCc>cTc	p.P286L	AMDHD2_ENST00000293971.6_Missense_Mutation_p.P286L|AMDHD2_ENST00000413459.3_Missense_Mutation_p.P286L|CEMP1_ENST00000382350.1_Intron|AMDHD2_ENST00000565570.1_Intron			Q9Y303	NAGA_HUMAN	amidohydrolase domain containing 2	286					N-acetylglucosamine metabolic process		N-acetylglucosamine-6-phosphate deacetylase activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(5)|prostate(3)|skin(2)|urinary_tract(2)	19						CGTGCCCATCCCCAGGGTAAG	0.662000													19	24					0	0	0.001882	0	0
ATHL1	80162	broad.mit.edu	37	11	294569	294569	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:294569C>T	ENST00000409548.2	+	14	2149	c.2034C>T	c.(2032-2034)tcC>tcT	p.S678S	ATHL1_ENST00000409479.1_Silent_p.S705S|ATHL1_ENST00000409655.1_Silent_p.S430S	NM_025092.4	NP_079368.3	Q32M88	ATHL1_HUMAN	ATH1, acid trehalase-like 1 (yeast)	678					carbohydrate metabolic process		hydrolase activity, acting on glycosyl bonds			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|liver(1)|lung(7)|prostate(1)|skin(3)	17		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;5.38e-28)|Epithelial(43;3.25e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		ACAAGGTCTCCTTTCCCCGCT	0.627000													37	29					0	0	0.006230	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103194685	103194685	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:103194685C>T	ENST00000375735.2	+	82	12150	c.12006C>T	c.(12004-12006)atC>atT	p.I4002I	DYNC2H1_ENST00000398093.3_Silent_p.I4009I|DYNC2H1_ENST00000334267.7_Intron	NM_001080463.1|NM_001377.2	NP_001073932.1|NP_001368.2	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	4002					cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity			NS(1)|endometrium(4)|kidney(5)|large_intestine(9)|lung(9)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)	33		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		CTGCCAATATCGCTCGCTCAT	0.388000													23	7					0	0	0.004656	0	0
ZNF821	55565	broad.mit.edu	37	16	71895750	71895750	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:71895750G>A	ENST00000425432.1	-	7	892	c.513C>T	c.(511-513)atC>atT	p.I171I	RP11-498D10.4_ENST00000569119.1_Intron|ZNF821_ENST00000446827.2_Silent_p.I129I|RP11-498D10.4_ENST00000568581.1_Intron|ZNF821_ENST00000313565.6_Silent_p.I129I|ZNF821_ENST00000565601.1_Silent_p.I171I|ZNF821_ENST00000564134.1_Intron	NM_001201552.1	NP_001188481.1	O75541	ZN821_HUMAN	zinc finger protein 821	171					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(1)|large_intestine(5)|lung(4)|ovary(2)	13						CCTCCGAGTGGATTAAGAGGT	0.582000													25	58					0	0	0.003954	0	0
ZMPSTE24	10269	broad.mit.edu	37	1	40756656	40756656	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:40756656C>T	ENST00000372759.3	+	9	1355	c.1190C>T	c.(1189-1191)tCa>tTa	p.S397L		NM_005857.4	NP_005848.2	O75844	FACE1_HUMAN	zinc metallopeptidase STE24	397						endoplasmic reticulum membrane|Golgi membrane|integral to membrane	metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	16	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			TTTATTTTTTCACCTTACAAT	0.343000													22	69					0	0	0.002780	0	0
SPATA18	132671	broad.mit.edu	37	4	52928431	52928431	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:52928431C>T	ENST00000295213.4	+	4	729	c.355C>T	c.(355-357)Cgg>Tgg	p.R119W	SPATA18_ENST00000506829.1_Intron|SPATA18_ENST00000419395.2_Missense_Mutation_p.R119W	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	119					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			TCCTCGGGATCGGGATATGCA	0.383000													53	132					0	0	0.003610	0	0
CFAP54	144535	broad.mit.edu	37	12	97078989	97078989	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:97078989G>A	ENST00000524981.3	+	9	1340	c.1340G>A	c.(1339-1341)gGa>gAa	p.G447E				Q6ZTY8	CL063_HUMAN		421										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(26)|ovary(1)|prostate(2)|skin(11)|stomach(2)	54						TGTTTGCAAGGAGCAGTCATA	0.507000													16	44					0	0	0.001216	0	0
ZAN	7455	broad.mit.edu	37	7	100382454	100382454	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:100382454C>T	ENST00000542585.1	+	0	6977				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000538115.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGGCTCCATCCCTGTGAGTGG	0.562000													8	9					0	0	0.003080	0	0
TAS2R7	50837	broad.mit.edu	37	12	10954787	10954787	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:10954787C>T	ENST00000240687.2	-	1	439	c.383G>A	c.(382-384)aGg>aAg	p.R128K		NM_023919.2	NP_076408.1	Q9NYW3	TA2R7_HUMAN	taste receptor, type 2, member 7	128					sensory perception of taste	integral to membrane	taste receptor activity			kidney(1)|large_intestine(1)|lung(3)|skin(2)|stomach(3)	10						GGAAATCACCCTGTCAATTCT	0.423000													12	10					0	0	0.001855	0	0
ALPK3	57538	broad.mit.edu	37	15	85400209	85400209	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:85400209C>T	ENST00000258888.5	+	6	3013	c.2846C>T	c.(2845-2847)cCt>cTt	p.P949L		NM_020778.4	NP_065829.3	Q96L96	ALPK3_HUMAN	alpha-kinase 3	949					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			NS(3)|breast(2)|central_nervous_system(2)|endometrium(12)|kidney(4)|large_intestine(9)|lung(27)|ovary(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	81			BRCA - Breast invasive adenocarcinoma(143;0.0587)			ACAGCGGGTCCTAGAGCTCCT	0.557000													33	43					0	0	0.003271	0	0
CYP11B2	1585	broad.mit.edu	37	8	143994088	143994088	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:143994088C>T	ENST00000323110.2	-	8	1258	c.1256G>A	c.(1255-1257)aGg>aAg	p.R419K		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	419					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	CCGCTCAGGCCTCGGGAACAA	0.617000									Familial Hyperaldosteronism type I				24	123					0	0	0.004656	0	0
OR8H2	390151	broad.mit.edu	37	11	55872764	55872764	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:55872764C>T	ENST00000313503.1	+	1	246	c.246C>T	c.(244-246)acC>acT	p.T82T		NM_001005200.1	NP_001005200.1	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H, member 2	82					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					CACCTAAAACCTTAGCGAACT	0.433000										HNSCC(53;0.14)			76	478					0	0	0.003610	0	0
COBL	23242	broad.mit.edu	37	7	51258552	51258552	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:51258552C>T	ENST00000395542.2	-	4	864	c.680G>A	c.(679-681)aGa>aAa	p.R227K	COBL_ENST00000441453.1_Missense_Mutation_p.R227K|COBL_ENST00000395540.2_Missense_Mutation_p.R227K|COBL_ENST00000265136.7_Missense_Mutation_p.R227K			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	227										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					CTCACCTCTTCTGTTGTCCCA	0.602000													5	16					0	0	0.001984	0	0
CCND3	896	broad.mit.edu	37	6	41909260	41909260	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:41909260G>A	ENST00000372991.4	-	1	326	c.128C>T	c.(127-129)tCc>tTc	p.S43F	CCND3_ENST00000511642.1_Intron|CCND3_ENST00000415497.2_Intron|CCND3_ENST00000511686.1_Intron|CCND3_ENST00000510503.1_Intron|CCND3_ENST00000372988.4_Intron|CCND3_ENST00000414200.2_Missense_Mutation_p.S43F	NM_001760.3	NP_001751.1	P30281	CCND3_HUMAN	cyclin D3	43	Cyclin N-terminal.				cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(13)|kidney(1)|large_intestine(1)|lung(2)|skin(1)	20	Colorectal(47;0.121)		Epithelial(12;0.000178)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CTGGAAGTAGGAGGCGCGGGG	0.721000			T	IGH@	MM								6	38					0	0	0.001168	0	0
HELZ2	85441	broad.mit.edu	37	20	62195450	62195450	+	Silent	SNP	G	G	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:62195450G>C	ENST00000467148.1	-	8	4794	c.4725C>G	c.(4723-4725)ccC>ccG	p.P1575P	HELZ2_ENST00000427522.2_Silent_p.P1006P	NM_001037335.2	NP_001032412.2			helicase with zinc finger 2, transcriptional coactivator																		GCAGTGACAGGGGCACCCGGT	0.711000													3	12					0	0	0.004672	0	0
C7orf31	136895	broad.mit.edu	37	7	25182418	25182418	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:25182418C>G	ENST00000409280.1	-	8	1008	c.700G>C	c.(700-702)Gag>Cag	p.E234Q	C7orf31_ENST00000283905.3_Missense_Mutation_p.E234Q			Q8N865	CG031_HUMAN	chromosome 7 open reading frame 31	234										autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|skin(2)|stomach(1)	14						TTATTTTTCTCAACACCTCTG	0.383000													30	29					0	0	0.001786	0	0
STK11IP	114790	broad.mit.edu	37	2	220476456	220476456	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:220476456C>T	ENST00000456909.1	+	18	2325	c.2235C>T	c.(2233-2235)gtC>gtT	p.V745V	STK11IP_ENST00000295641.10_Silent_p.V756V			Q8N1F8	S11IP_HUMAN	serine/threonine kinase 11 interacting protein	756					protein localization	cytoplasm	protein kinase binding			breast(2)|endometrium(5)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	23		Renal(207;0.0183)		Epithelial(149;2.69e-07)|all cancers(144;5.91e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCAGCCCTGTCTGCCACCCTC	0.637000													13	16					0	0	0.001855	0	0
SSH2	85464	broad.mit.edu	37	17	27958542	27958542	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:27958542C>T	ENST00000269033.3	-	15	3740	c.3589G>A	c.(3589-3591)Ggg>Agg	p.G1197R	RP11-68I3.2_ENST00000581474.1_RNA|SSH2_ENST00000540801.1_Missense_Mutation_p.G1224R	NM_033389.2	NP_203747.2	Q76I76	SSH2_HUMAN	slingshot protein phosphatase 2	1197					actin cytoskeleton organization|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity		SSH2/SUZ12(2)	breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(16)|ovary(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						TGTAACTCCCCAGTGTTGTCA	0.502000													34	116					0	0	0.006230	0	0
H2AFV	94239	broad.mit.edu	37	7	44880610	44880610	+	Splice_Site	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:44880610A>T	ENST00000222690.6	-	3	188	c.81_splice	c.e3-1	p.F28_splice	H2AFV_ENST00000446531.1_Splice_Site_p.F28_splice|H2AFV_ENST00000521529.1_Splice_Site_p.F2_splice|H2AFV_ENST00000381124.5_Splice_Site_p.F28_splice|H2AFV_ENST00000437072.1_Intron|H2AFV_ENST00000350771.3_Splice_Site_p.F2_splice|H2AFV_ENST00000308153.4_Splice_Site_p.F28_splice|H2AFV_ENST00000349299.3_Intron	NM_138635.3	NP_619541.1	Q71UI9	H2AV_HUMAN	H2A histone family, member V	28					nucleosome assembly	nucleosome|nucleus	DNA binding			endometrium(2)|large_intestine(1)|lung(4)|prostate(1)|urinary_tract(1)	9						GCCCACAGGAAACTAAAAGAG	0.473000													45	65					0	0	0.003610	0	0
GRIA1	2890	broad.mit.edu	37	5	153175112	153175112	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:153175112G>A	ENST00000340592.5	+	14	2420	c.2347G>A	c.(2347-2349)Gat>Aat	p.D783N	GRIA1_ENST00000518142.1_Intron|GRIA1_ENST00000285900.5_Intron|GRIA1_ENST00000448073.4_Missense_Mutation_p.D793N|GRIA1_ENST00000521843.2_Intron|GRIA1_ENST00000518783.1_Intron	NM_001114183.1|NM_001258020.1	NP_001107655.1|NP_001244949.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	783					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	ATGGTGGTACGATAAAGGGGA	0.483000													17	22					0	0	0.007413	0	0
DHX34	9704	broad.mit.edu	37	19	47884494	47884494	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:47884494C>A	ENST00000328771.4	+	16	3560	c.3211C>A	c.(3211-3213)Cac>Aac	p.H1071N		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	1071						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		GACCTGCCCCCACTGTGGCCT	0.672000													17	23					2.35188e-11	4.00461e-11	0.006122	1	0
SLIT2	9353	broad.mit.edu	37	4	20555447	20555447	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:20555447C>T	ENST00000504154.1	+	26	2833	c.2581C>T	c.(2581-2583)Ctt>Ttt	p.L861F	SLIT2_ENST00000503837.1_Missense_Mutation_p.L857F|SLIT2_ENST00000503823.1_Missense_Mutation_p.L853F|SLIT2_ENST00000273739.5_Missense_Mutation_p.L865F	NM_004787.1	NP_004778.1	O94813	SLIT2_HUMAN	slit homolog 2 (Drosophila)	861	LRRCT 4.				apoptosis involved in luteolysis|axon extension involved in axon guidance|branching morphogenesis of a tube|cell migration involved in sprouting angiogenesis|cellular response to heparin|cellular response to hormone stimulus|chemorepulsion involved in postnatal olfactory bulb interneuron migration|corticospinal neuron axon guidance through spinal cord|induction of negative chemotaxis|motor axon guidance|negative regulation of actin filament polymerization|negative regulation of cell growth|negative regulation of cellular response to growth factor stimulus|negative regulation of chemokine-mediated signaling pathway|negative regulation of endothelial cell migration|negative regulation of lamellipodium assembly|negative regulation of mononuclear cell migration|negative regulation of neutrophil chemotaxis|negative regulation of protein phosphorylation|negative regulation of retinal ganglion cell axon guidance|negative regulation of small GTPase mediated signal transduction|negative regulation of smooth muscle cell chemotaxis|negative regulation of vascular permeability|positive regulation of apoptosis|positive regulation of axonogenesis|response to cortisol stimulus|retinal ganglion cell axon guidance|Roundabout signaling pathway|ureteric bud development	cell surface|cytoplasm|extracellular space|plasma membrane	calcium ion binding|GTPase inhibitor activity|heparin binding|laminin-1 binding|protein homodimerization activity|proteoglycan binding|Roundabout binding			NS(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(17)|lung(60)|ovary(3)|pancreas(1)|prostate(2)|skin(10)|upper_aerodigestive_tract(1)	116						AGCCAACCCTCTTTACTGTGA	0.463000													11	91					0	0	0.001368	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	T	rs121913529		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:25398284C>T	ENST00000311936.3	-	2	226	c.35G>A	c.(34-36)gGt>gAt	p.G12D	KRAS_ENST00000557334.1_Missense_Mutation_p.G12D|KRAS_ENST00000256078.4_Missense_Mutation_p.G12D|KRAS_ENST00000556131.1_Missense_Mutation_p.G12D	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			44	2					0	0	0.003610	0	0
CACNA2D1	781	broad.mit.edu	37	7	81598265	81598265	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:81598265G>A	ENST00000356860.3	-	29	2671	c.2333C>T	c.(2332-2334)tCg>tTg	p.S778L	CACNA2D1_ENST00000356253.5_Missense_Mutation_p.S790L|CACNA2D1_ENST00000535308.1_Intron	NM_000722.2	NP_000713.2	P54289	CA2D1_HUMAN	calcium channel, voltage-dependent, alpha 2/delta subunit 1	790						voltage-gated calcium channel complex	metal ion binding			breast(2)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(15)|liver(1)|lung(42)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	81					Felodipine(DB01023)|Gabapentin(DB00996)|Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Nifedipine(DB01115)	CATAATGCCCGATTCATAGGC	0.279000													43	53					0	0	0.003610	0	0
P2RX7	5027	broad.mit.edu	37	12	121605371	121605371	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:121605371C>T	ENST00000328963.5	+	7	769	c.315C>T	c.(313-315)ttC>ttT	p.F105F	P2RX7_ENST00000443520.3_3'UTR|P2RX7_ENST00000535250.1_Silent_p.F185F|P2RX7_ENST00000377162.2_Intron|P2RX7_ENST00000546057.1_Silent_p.F275F|P2RX7_ENST00000541446.1_Intron			A8K2Z0	A8K2Z0_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 7	275						integral to membrane	ATP binding|ion channel activity|receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|stomach(1)	19	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					AATACAGTTTCCGTCGCCTTG	0.532000													88	260					0	0	0.003610	0	0
COL28A1	340267	broad.mit.edu	37	7	7457497	7457497	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:7457497C>T	ENST00000399429.3	-	27	2269	c.2129G>A	c.(2128-2130)gGa>gAa	p.G710E		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	710					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		TACTTTAATTCCCTGTGATCC	0.463000													17	177					0	0	0.007413	0	0
SLA2	84174	broad.mit.edu	37	20	35242336	35242336	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:35242336C>T	ENST00000262866.4	-	8	1141	c.719G>A	c.(718-720)gGt>gAt	p.G240D	SLA2_ENST00000360672.2_3'UTR	NM_032214.3|NM_175077.2	NP_115590.1|NP_778252.1	Q9H6Q3	SLAP2_HUMAN	Src-like-adaptor 2	240	SLA C-terminal.				antigen receptor-mediated signaling pathway|B cell mediated immunity|intracellular receptor mediated signaling pathway|negative regulation of B cell activation|negative regulation of calcium-mediated signaling|negative regulation of transcription from RNA polymerase II promoter|T cell activation	cytoplasmic membrane-bounded vesicle|endosome membrane|plasma membrane	protein N-terminus binding|SH3/SH2 adaptor activity			endometrium(1)|lung(2)|skin(2)	5	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				CTCCCGGAGACCCTCACTGAG	0.542000													18	53					0	0	0.006122	0	0
MUC16	94025	broad.mit.edu	37	19	9090331	9090331	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9090331G>A	ENST00000397910.4	-	1	1687	c.1484C>T	c.(1483-1485)tCc>tTc	p.S495F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	495	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AGCTGTGCTGGAACTCTGCCT	0.532000													34	30					0	0	0.004289	0	0
SV2C	22987	broad.mit.edu	37	5	75428043	75428043	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:75428043C>T	ENST00000502798.2	+	2	910	c.468C>T	c.(466-468)ttC>ttT	p.F156F	SV2C_ENST00000322285.7_Silent_p.F156F	NM_014979.1	NP_055794.1	Q496J9	SV2C_HUMAN	synaptic vesicle glycoprotein 2C	156					neurotransmitter transport	cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			NS(1)|breast(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(5)|lung(14)|ovary(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	37		all_lung(232;0.007)|Lung NSC(167;0.0148)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;1.16e-50)|all cancers(79;7.25e-40)		CCCTTTTCTTCGTCCTGGGCA	0.507000													59	72					0	0	0.003610	0	0
DGKD	8527	broad.mit.edu	37	2	234355402	234355402	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:234355402C>T	ENST00000264057.2	+	12	1391	c.1379C>T	c.(1378-1380)tCc>tTc	p.S460F	DGKD_ENST00000409813.3_Missense_Mutation_p.S416F	NM_152879.2	NP_690618.2	Q16760	DGKD_HUMAN	diacylglycerol kinase, delta 130kDa	460					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell growth|diacylglycerol metabolic process|endocytosis|epidermal growth factor receptor signaling pathway|multicellular organismal development|platelet activation|protein homooligomerization|protein transport|response to organic substance|second-messenger-mediated signaling	cytoplasm|cytoplasmic membrane-bounded vesicle|plasma membrane	ATP binding|diacylglycerol binding|diacylglycerol kinase activity|metal ion binding|protein heterodimerization activity|protein homodimerization activity			central_nervous_system(2)|endometrium(4)|kidney(1)|large_intestine(13)|lung(15)|ovary(1)|pancreas(1)|skin(1)	38		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0538)		Epithelial(121;1.31e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000416)|Lung(119;0.00285)|LUSC - Lung squamous cell carcinoma(224;0.00655)	Phosphatidylserine(DB00144)	CGGCAGGCCTCCTCCTCTACC	0.597000													28	34					0	0	0.002096	0	0
LDHA	3939	broad.mit.edu	37	11	18421065	18421065	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:18421065C>T	ENST00000422447.3	+	3	487	c.214C>T	c.(214-216)Ctt>Ttt	p.L72F	LDHA_ENST00000396222.2_Missense_Mutation_p.L72F|LDHA_ENST00000430553.2_Missense_Mutation_p.L72F|LDHA_ENST00000540430.1_Missense_Mutation_p.L101F|LDHA_ENST00000227157.4_Missense_Mutation_p.L72F|LDHA_ENST00000379412.5_Missense_Mutation_p.L72F|LDHA_ENST00000542179.1_Missense_Mutation_p.L72F	NM_001135239.1|NM_005566.3	NP_001128711.1|NP_005557.1	P00338	LDHA_HUMAN	lactate dehydrogenase A	72					glycolysis|pyruvate metabolic process	cytosol	L-lactate dehydrogenase activity|protein binding			central_nervous_system(3)|endometrium(1)|large_intestine(4)|lung(4)	12					NADH(DB00157)	CAGCCTTTTCCTTAGAACACC	0.383000													29	33					0	0	0.003271	0	0
EXOC6B	23233	broad.mit.edu	37	2	72786608	72786608	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:72786608G>A	ENST00000272427.6	-	8	1019	c.889C>T	c.(889-891)Cga>Tga	p.R297*	EXOC6B_ENST00000410104.1_Nonsense_Mutation_p.R297*	NM_015189.1	NP_056004.1	Q9Y2D4	EXC6B_HUMAN	exocyst complex component 6B	297					protein transport|vesicle docking involved in exocytosis	exocyst				breast(1)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(3)	10						TGTAGACATCGATAAACTGGA	0.368000													7	29					0	0	0.001984	0	0
FADS6	283985	broad.mit.edu	37	17	72875693	72875693	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:72875693G>A	ENST00000310226.6	-	5	761	c.747C>T	c.(745-747)ttC>ttT	p.F249F		NM_178128.3	NP_835229.2	Q8N9I5	FADS6_HUMAN	fatty acid desaturase 6	255					fatty acid biosynthetic process	integral to membrane	oxidoreductase activity			endometrium(3)|kidney(1)|lung(4)	8	all_lung(278;0.172)|Lung NSC(278;0.207)					TGTCCCGGGAGAACATGGGCA	0.652000													8	18					0	0	0.006214	0	0
OR6C75	390323	broad.mit.edu	37	12	55759263	55759263	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:55759263C>T	ENST00000343399.3	+	1	369	c.369C>T	c.(367-369)gcC>gcT	p.A123A		NM_001005497.1	NP_001005497.1	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C, member 75	123					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(2)|large_intestine(5)|lung(11)|ovary(3)|skin(2)|upper_aerodigestive_tract(2)	25						GCTGCATGGCCATCTGCAAAC	0.453000													15	34					0	0	0.002450	0	0
SYT6	148281	broad.mit.edu	37	1	114636410	114636410	+	Nonstop_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:114636410A>C	ENST00000393296.1	-	7	1608	c.1531T>G	c.(1531-1533)Tga>Gga	p.*511G	SYT6_ENST00000369547.1_Nonstop_Mutation_p.*426G			Q5T7P8	SYT6_HUMAN	synaptotagmin VI	0					acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			central_nervous_system(1)|endometrium(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAATGAAATCACAACCGAGGG	0.453000													33	79					0	0	0.003271	0	0
SLC35C1	55343	broad.mit.edu	37	11	45832552	45832552	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:45832552C>T	ENST00000314134.3	+	2	2157	c.761C>T	c.(760-762)gCc>gTc	p.A254V	SLC35C1_ENST00000442528.2_Missense_Mutation_p.A241V|SLC35C1_ENST00000456334.1_Missense_Mutation_p.A241V	NM_018389.4	NP_060859.4	Q96A29	FUCT1_HUMAN	solute carrier family 35 (GDP-fucose transporter), member C1	254						Golgi membrane|integral to membrane	GDP-fucose transmembrane transporter activity			endometrium(3)|kidney(1)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	10				GBM - Glioblastoma multiforme(35;0.227)		GAGCTTCAGGCCCTGCGTGAC	0.637000													11	14					0	0	0.000673	0	0
HDAC3	8841	broad.mit.edu	37	5	141009682	141009682	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:141009682G>A	ENST00000305264.3	-	4	371	c.292C>T	c.(292-294)Ccc>Tcc	p.P98S		NM_003883.3	NP_003874.2	O15379	HDAC3_HUMAN	histone deacetylase 3	98	Histone deacetylase.				anti-apoptosis|cellular lipid metabolic process|negative regulation of cell cycle|negative regulation of JNK cascade|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|spindle assembly|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|spindle microtubule|transcriptional repressor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|transcription corepressor activity|transcription factor binding			endometrium(1)|large_intestine(2)|lung(3)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	13			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)		Vorinostat(DB02546)	AAGAGCCCGGGAAACACTGGG	0.557000													67	63					0	0	0.003610	0	0
ZNF74	7625	broad.mit.edu	37	22	20760971	20760971	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:20760971C>T	ENST00000400451.2	+	5	2162	c.1648C>T	c.(1648-1650)Cac>Tac	p.H550Y	ZNF74_ENST00000357502.5_3'UTR|ZNF74_ENST00000403682.3_3'UTR|ZNF74_ENST00000405993.1_Missense_Mutation_p.H518Y|ZNF74_ENST00000356671.5_Missense_Mutation_p.H550Y	NM_003426.3	NP_003417.2	Q16587	ZNF74_HUMAN	zinc finger protein 74	550					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	actin cytoskeleton|nucleus	DNA binding|RNA binding|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(4)|lung(7)|ovary(1)|skin(1)|urinary_tract(1)	19	Melanoma(16;0.000465)|Ovarian(15;0.0025)|Colorectal(54;0.0221)|all_neural(72;0.219)	Lung SC(17;0.0262)|all_lung(157;0.248)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			TCAGAAAATCCACTCCGGGGA	0.562000													18	67					0	0	0.007413	0	0
PCDHGB6	56100	broad.mit.edu	37	5	140789035	140789035	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140789035C>T	ENST00000520790.1	+	1	1266	c.1266C>T	c.(1264-1266)atC>atT	p.I422I	PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA9_ENST00000573521.1_Intron	NM_018926.2|NM_032100.1	NP_061749.1|NP_115271.1														breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(10)|lung(16)|ovary(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(2)	48			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGTCACCATCGTAGCCACTG	0.483000													35	45					0	0	0.004289	0	0
MIR525	574470	broad.mit.edu	37	19	54200848	54200848	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54200848C>T	ENST00000384978.1	+	0	62					NR_030192.1																						GAAGGCGCTTCCCTTTAGAGC	0.423000													16	54					0	0	0.007413	0	0
BSN	8927	broad.mit.edu	37	3	49691938	49691938	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:49691938G>A	ENST00000296452.4	+	5	5063	c.4949G>A	c.(4948-4950)gGg>gAg	p.G1650E		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	1650					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding	p.G1650E(1)		breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TCTGTCCCTGGGACGTCTAGG	0.642000													9	17					0	0	0.004482	0	0
GCNT3	9245	broad.mit.edu	37	15	59911093	59911093	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:59911093C>T	ENST00000396065.1	+	3	1104	c.656C>T	c.(655-657)cCg>cTg	p.P219L	GCNT3_ENST00000560585.1_Missense_Mutation_p.P219L	NM_004751.2	NP_004742.1	O95395	GCNT3_HUMAN	glucosaminyl (N-acetyl) transferase 3, mucin type	219					protein O-linked glycosylation	Golgi membrane|integral to membrane|membrane fraction	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			central_nervous_system(1)|cervix(1)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						AGCTCAGTGCCGTGGAAATAC	0.502000													42	55					0	0	0.002222	0	0
TBX15	6913	broad.mit.edu	37	1	119428089	119428089	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:119428089G>A	ENST00000369429.3	-	8	1084	c.1075C>T	c.(1075-1077)Cct>Tct	p.P359S	TBX15_ENST00000207157.3_Missense_Mutation_p.P253S			Q96SF7	TBX15_HUMAN	T-box 15	359						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(19)|ovary(1)|pancreas(1)|skin(5)	37	all_neural(166;0.117)	all_cancers(81;0.000692)|all_lung(203;3.05e-06)|Lung NSC(69;2.13e-05)|all_epithelial(167;0.000237)		Lung(183;0.044)|LUSC - Lung squamous cell carcinoma(189;0.141)		GAAGCCGAAGGGGATGGTGTC	0.488000													6	18					0	0	0.003080	0	0
FGD5	152273	broad.mit.edu	37	3	14964650	14964650	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:14964650A>C	ENST00000285046.5	+	16	4015	c.3905A>C	c.(3904-3906)aAg>aCg	p.K1302T	FGD5_ENST00000476851.1_3'UTR|FGD5-AS1_ENST00000430166.1_RNA|FGD5_ENST00000543601.1_Missense_Mutation_p.K1061T	NM_152536.3	NP_689749.3	Q6ZNL6	FGD5_HUMAN	FYVE, RhoGEF and PH domain containing 5	1302					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			NS(2)|breast(2)|endometrium(3)|kidney(5)|large_intestine(10)|lung(25)|ovary(3)|pancreas(1)|prostate(2)|urinary_tract(1)	54						GAGCTGAAGAAGCGGGGCAGG	0.617000													9	22					0	0	0.006214	0	0
TSC2	7249	broad.mit.edu	37	16	2131601	2131601	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:2131601A>G	ENST00000219476.3	+	31	4246	c.3616A>G	c.(3616-3618)Acc>Gcc	p.T1206A	TSC2_ENST00000353929.4_Missense_Mutation_p.T1163A|TSC2_ENST00000568454.1_Missense_Mutation_p.T1173A|TSC2_ENST00000382538.6_Missense_Mutation_p.T1114A|TSC2_ENST00000401874.2_Missense_Mutation_p.T1162A|TSC2_ENST00000439673.2_Missense_Mutation_p.T1126A|TSC2_ENST00000350773.4_Missense_Mutation_p.T1206A	NM_000548.3	NP_000539.2	P49815	TSC2_HUMAN	tuberous sclerosis 2	1206					cell cycle arrest|endocytosis|heart development|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|negative regulation of cell size|negative regulation of phosphatidylinositol 3-kinase cascade|negative regulation of protein kinase B signaling cascade|negative regulation of TOR signaling cascade|negative regulation of Wnt receptor signaling pathway|nerve growth factor receptor signaling pathway|neural tube closure|phosphatidylinositol-mediated signaling|positive chemotaxis|protein import into nucleus|protein kinase B signaling cascade|regulation of endocytosis|regulation of insulin receptor signaling pathway|regulation of small GTPase mediated signal transduction	Golgi apparatus|nucleus|perinuclear region of cytoplasm|TSC1-TSC2 complex	GTPase activator activity|protein homodimerization activity			NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(4)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(3)|lung(19)|ovary(2)|pancreas(1)|prostate(2)|skin(7)|soft_tissue(1)	56		Hepatocellular(780;0.0202)				CGCAGGGAACACCAGCTGGCT	0.647000			"""D, Mis, N, F, S"""			"""hamartoma, renal cell"""			Tuberous Sclerosis				25	44					0	0	0.003954	0	0
OR6K3	391114	broad.mit.edu	37	1	158686981	158686981	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:158686981C>T	ENST00000368146.1	-	1	972	c.973G>A	c.(973-975)Gtg>Atg	p.V325M	OR6K3_ENST00000368145.1_Missense_Mutation_p.V309M			Q8NGY3	OR6K3_HUMAN	olfactory receptor, family 6, subfamily K, member 3	325					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(21)|ovary(1)|prostate(1)|skin(2)|stomach(1)	41	all_hematologic(112;0.0378)					TTGTTCAACACTTTTTGAAGA	0.393000													24	121					0	0	0.007291	0	0
PC	5091	broad.mit.edu	37	11	66617702	66617702	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:66617702C>T	ENST00000393960.1	-	19	2988	c.2707G>A	c.(2707-2709)Gat>Aat	p.D903N	PC_ENST00000393958.2_Missense_Mutation_p.D903N|PC_ENST00000529047.1_Missense_Mutation_p.D23N|PC_ENST00000393955.2_Missense_Mutation_p.D903N	NM_001040716.1	NP_001035806.1	P11498	PYC_HUMAN	pyruvate carboxylase	903					gluconeogenesis|lipid biosynthetic process	mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|pyruvate carboxylase activity			cervix(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	32		Melanoma(852;0.0525)		Lung(977;0.153)|LUSC - Lung squamous cell carcinoma(976;0.227)	Biotin(DB00121)|Pyruvic acid(DB00119)	TTGATGAGATCGCCCAGCATC	0.617000													21	41					0	0	0.002299	0	0
CDH6	1004	broad.mit.edu	37	5	31305295	31305295	+	Silent	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:31305295A>G	ENST00000265071.2	+	7	1279	c.1014A>G	c.(1012-1014)gaA>gaG	p.E338E	CDH6_ENST00000514738.1_Silent_p.E283E	NM_004932.3	NP_004923.1	P55285	CADH6_HUMAN	cadherin 6, type 2, K-cadherin (fetal kidney)	338	Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			NS(3)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(42)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	77						TGGACTTTGAAAAGAAGAAAG	0.433000													23	87					0	0	0.003954	0	0
ZEB1	6935	broad.mit.edu	37	10	31810768	31810768	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:31810768G>A	ENST00000446923.2	+	7	2848	c.2457G>A	c.(2455-2457)acG>acA	p.T819T	ZEB1_ENST00000542815.3_Silent_p.T768T|ZEB1_ENST00000560721.2_Silent_p.T815T|ZEB1_ENST00000320985.10_Silent_p.T835T|ZEB1_ENST00000559858.1_3'UTR|ZEB1_ENST00000361642.5_Silent_p.T836T	NM_001128128.2|NM_001174094.1	NP_001121600.1|NP_001167565.1	P37275	ZEB1_HUMAN	zinc finger E-box binding homeobox 1	835					cell proliferation|immune response|negative regulation of transcription from RNA polymerase II promoter|positive regulation of neuron differentiation	cytoplasm	E-box binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(14)|lung(38)|ovary(3)|skin(6)|upper_aerodigestive_tract(4)	77		Prostate(175;0.0156)				ATAAGCAAACGATTCTGATTC	0.498000													23	26					0	0	0.004656	0	0
ACOX3	8310	broad.mit.edu	37	4	8383293	8383293	+	Nonsense_Mutation	SNP	G	G	A	rs146945288		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:8383293G>A	ENST00000356406.5	-	14	1656	c.1579C>T	c.(1579-1581)Cga>Tga	p.R527*	ACOX3_ENST00000413009.2_Nonsense_Mutation_p.R527*|ACOX3_ENST00000503233.1_Nonsense_Mutation_p.R527*	NM_003501.2	NP_003492.2	O15254	ACOX3_HUMAN	acyl-CoA oxidase 3, pristanoyl	527					bile acid metabolic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding|pristanoyl-CoA oxidase activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(9)|lung(17)|prostate(1)|skin(3)|stomach(1)	42						TAAGTCTCTCGGAGCAGGTAG	0.408000													32	159					0	0	0.002836	0	0
ABCA8	10351	broad.mit.edu	37	17	66925360	66925360	+	Silent	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:66925360A>G	ENST00000269080.2	-	8	1092	c.955T>C	c.(955-957)Tta>Cta	p.L319L	ABCA8_ENST00000586539.1_Silent_p.L319L|ABCA8_ENST00000430352.2_Silent_p.L319L	NM_007168.2	NP_009099.1	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 8	319						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(3)|central_nervous_system(2)|endometrium(9)|kidney(5)|large_intestine(19)|liver(1)|lung(30)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|urinary_tract(4)	83	Breast(10;4.56e-13)					ATGCTCATTAAGAAAGCCAAA	0.373000													17	17					0	0	0.004990	0	0
AADACL3	126767	broad.mit.edu	37	1	12785820	12785820	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:12785820G>A	ENST00000332530.3	+	3	926	c.700G>A	c.(700-702)Gaa>Aaa	p.E234K	AADACL3_ENST00000359318.5_Missense_Mutation_p.E304K	NM_001103169.1	NP_001096639.1	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3	304							hydrolase activity			breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	15	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		GAAAAGGCTGGAAGACCTGGG	0.517000													21	62					0	0	0.001523	0	0
HERPUD1	9709	broad.mit.edu	37	16	56973251	56973251	+	Silent	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:56973251A>T	ENST00000439977.2	+	5	731	c.534A>T	c.(532-534)gcA>gcT	p.A178A	HERPUD1_ENST00000570273.1_3'UTR|HERPUD1_ENST00000344114.4_Intron|HERPUD1_ENST00000379792.2_Silent_p.A153A|HERPUD1_ENST00000300302.5_Silent_p.A177A	NM_001010989.1|NM_014685.2	NP_001010989.1|NP_055500.1	Q15011	HERP1_HUMAN	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	178						endoplasmic reticulum membrane|integral to membrane	protein binding			cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|stomach(1)	11						AGATATATGCACGACAGTACT	0.527000			T	ERG	prostate								48	114					0	0	0.003610	0	0
APRT	353	broad.mit.edu	37	16	88876249	88876249	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:88876249C>T	ENST00000378364.3	-	5	445		c.e5-1		APRT_ENST00000426324.2_Intron|APRT_ENST00000563655.1_Splice_Site	NM_000485.2	NP_000476.1	P07741	APT_HUMAN	adenine phosphoribosyltransferase						purine ribonucleoside salvage	cytosol|nucleus	adenine phosphoribosyltransferase activity|AMP binding|protein binding			cervix(1)|endometrium(1)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(80;0.0477)	Adenine(DB00173)|Adenosine monophosphate(DB00131)	TTCATGGTTCCTGGGGATGGG	0.662000													7	21					0	0	0.001984	0	0
STON2	85439	broad.mit.edu	37	14	81837529	81837529	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:81837529G>A	ENST00000555447.1	-	5	786	c.373_splice	c.e5-1	p.A125_splice	STON2_ENST00000267540.2_Splice_Site_p.A125_splice	NM_001256430.1	NP_001243359.1	Q8WXE9	STON2_HUMAN	stonin 2	125					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|lung(13)|pancreas(2)|prostate(1)|skin(5)	34				BRCA - Breast invasive adenocarcinoma(234;0.0348)		CAATGGTAGGGCTGGGGAGAG	0.448000													22	39					0	0	0.001523	0	0
DOCK9	23348	broad.mit.edu	37	13	99575589	99575589	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:99575589G>A	ENST00000376460.1	-	5	533	c.453C>T	c.(451-453)gtC>gtT	p.V151V	DOCK9_ENST00000442173.1_Silent_p.V151V|DOCK9_ENST00000339416.2_Silent_p.V152V|DOCK9_ENST00000448493.2_Silent_p.V163V	NM_001130048.1|NM_015296.2	NP_001123520.1|NP_056111.1	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9	152					blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			breast(3)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(12)|lung(18)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	59	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CAACTTCATAGACATGAACTG	0.373000													31	71					0	0	0.005524	0	0
TRIM21	6737	broad.mit.edu	37	11	4410955	4410955	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:4410955C>T	ENST00000254436.7	-	3	545	c.433G>A	c.(433-435)Gaa>Aaa	p.E145K	TRIM21_ENST00000543625.1_Missense_Mutation_p.E145K	NM_003141.3	NP_003132.2	P19474	RO52_HUMAN	tripartite motif containing 21	145					cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(3)	16		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		CTTCTCAGTTCCCCTAATGCC	0.463000													53	49					0	0	0.003610	0	0
DNMT3L	29947	broad.mit.edu	37	21	45681098	45681098	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:45681098C>T	ENST00000270172.3	-	2	528	c.45G>A	c.(43-45)atG>atA	p.M15I	DNMT3L_ENST00000418993.1_Missense_Mutation_p.M15I	NM_013369.3	NP_037501.2	Q9UJW3	DNM3L_HUMAN	DNA (cytosine-5-)-methyltransferase 3-like	15					DNA methylation|negative regulation of transcription, DNA-dependent|regulation of gene expression by genetic imprinting|spermatogenesis	cytosol	enzyme activator activity|enzyme binding|metal ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)|skin(3)	11				Colorectal(79;0.0165)|READ - Rectum adenocarcinoma(84;0.0781)		AAATCACGTCCATGCTGGGCT	0.597000													24	40					0	0	0.003330	0	0
MUC16	94025	broad.mit.edu	37	19	9062833	9062833	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9062833C>T	ENST00000397910.4	-	3	24816	c.24613G>A	c.(24613-24615)Gat>Aat	p.D8205N		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8207	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						CCAGGAGGATCTGTTTGTGTC	0.468000													16	18					0	0	0.007413	0	0
GBP2	2634	broad.mit.edu	37	1	89582871	89582871	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:89582871G>A	ENST00000370466.3	-	6	940	c.672C>T	c.(670-672)atC>atT	p.I224I	GBP2_ENST00000463660.1_5'UTR	NM_004120.3	NP_004111.2	P32456	GBP2_HUMAN	guanylate binding protein 2, interferon-inducible	224					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(2)|skin(1)	20		Lung NSC(277;0.0908)		all cancers(265;0.0151)|Epithelial(280;0.0284)		AGAACTTTCGGATGCACAACC	0.403000													16	26					0	0	0.007413	0	0
SEC24B	10427	broad.mit.edu	37	4	110447419	110447419	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:110447419C>T	ENST00000265175.5	+	17	2884	c.2829C>T	c.(2827-2829)gtC>gtT	p.V943V	SEC24B_ENST00000399100.2_Silent_p.V908V|SEC24B_ENST00000504968.2_Silent_p.V973V	NM_006323.2	NP_006314.2	O95487	SC24B_HUMAN	SEC24 family member B	943					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			breast(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(12)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		ACTTCTTTGTCCGTTCTACTG	0.353000													42	72					0	0	0.002852	0	0
F5	2153	broad.mit.edu	37	1	169484697	169484697	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:169484697G>A	ENST00000367796.3	-	24	6729	c.6528C>T	c.(6526-6528)tcC>tcT	p.S2176S	F5_ENST00000367797.3_Silent_p.S2171S|F5_ENST00000495481.1_5'UTR			P12259	FA5_HUMAN	coagulation factor V (proaccelerin, labile factor)	2171	F5/8 type C 2.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			NS(1)|breast(4)|central_nervous_system(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(55)|ovary(3)|prostate(4)|skin(5)|stomach(1)|upper_aerodigestive_tract(7)|urinary_tract(1)	128	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CCACCATGGAGGATTTCAGCC	0.438000													210	114					0	0	0.003610	0	0
PLEKHH2	130271	broad.mit.edu	37	2	43927012	43927012	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:43927012C>T	ENST00000282406.4	+	8	1025	c.915C>T	c.(913-915)acC>acT	p.T305T		NM_172069.3	NP_742066.2	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H (with MyTH4 domain) member 2	305						cytoplasm|cytoskeleton|integral to membrane	binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(12)|lung(24)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	56		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				GCACATCCACCCTCTCCAGTC	0.512000													106	248					0	0	0.003610	0	0
OR5H2	79310	broad.mit.edu	37	3	98002015	98002015	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:98002015G>A	ENST00000355273.2	+	1	284	c.284G>A	c.(283-285)aGg>aAg	p.R95K	RP11-325B23.2_ENST00000508616.1_lincRNA	NM_001005482.1	NP_001005482.1	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H, member 2	95					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(1)|large_intestine(5)|lung(13)|ovary(3)|upper_aerodigestive_tract(1)	24						GCCAAAAACAGGATGATATCT	0.373000													49	105					0	0	0.003610	0	0
KLRC2	3822	broad.mit.edu	37	12	10587971	10587971	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:10587971G>A	ENST00000381902.2	-	2	232	c.226C>T	c.(226-228)Cta>Tta	p.L76L	KLRC2_ENST00000536833.2_Silent_p.L17L|KLRC2_ENST00000381901.1_Silent_p.L76L|NKG2-E_ENST00000539033.1_Silent_p.L76L	NM_002260.3	NP_002251.2	P26717	NKG2C_HUMAN	killer cell lectin-like receptor subfamily C, member 2	76					cellular defense response	integral to plasma membrane	sugar binding|transmembrane receptor activity			kidney(2)|large_intestine(1)|lung(6)|ovary(1)|skin(1)	11						ATGATTCCTAGGACCTCGGCA	0.423000													44	77					0	0	0.003610	0	0
POLR2E	5434	broad.mit.edu	37	19	1091854	1091854	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:1091854C>T	ENST00000215587.7	-	3	568	c.285G>A	c.(283-285)caG>caA	p.Q95Q	POLR2E_ENST00000585838.1_5'UTR|POLR2E_ENST00000586746.1_Silent_p.Q95Q			P19388	RPAB1_HUMAN	polymerase (RNA) II (DNA directed) polypeptide E, 25kDa	95					interspecies interaction between organisms|mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase II promoter|transcription elongation from RNA polymerase III promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|skin(2)	11		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTTCTCCTCCTGCATGCGCT	0.662000													24	27					0	0	0.003954	0	0
RIF1	55183	broad.mit.edu	37	2	152308153	152308153	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:152308153A>G	ENST00000243326.4	+	20	2761	c.2278A>G	c.(2278-2280)Att>Gtt	p.I760V	RIF1_ENST00000428287.2_Missense_Mutation_p.I760V|RIF1_ENST00000453091.2_Missense_Mutation_p.I760V|RIF1_ENST00000430328.2_Missense_Mutation_p.I760V|RIF1_ENST00000444746.2_Missense_Mutation_p.I760V			Q5UIP0	RIF1_HUMAN	RAP1 interacting factor homolog (yeast)	760					cell cycle|response to DNA damage stimulus	chromosome, telomeric region|cytoplasm|nucleus|spindle	binding			NS(2)|breast(8)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(19)|liver(1)|lung(34)|ovary(6)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	97				BRCA - Breast invasive adenocarcinoma(221;0.0429)		TATTTATATTATTACTGTAAT	0.303000													29	19					0	0	0.002096	0	0
KRT83	3889	broad.mit.edu	37	12	52715036	52715036	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:52715036G>A	ENST00000293670.3	-	1	146	c.84C>T	c.(82-84)agC>agT	p.S28S		NM_002282.3	NP_002273.3	P78385	KRT83_HUMAN	keratin 83	28	Head.				epidermis development	keratin filament	structural molecule activity			NS(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(9)|prostate(1)|skin(4)|stomach(7)|upper_aerodigestive_tract(1)	32	Myeloproliferative disorder(4;0.0484)|all_hematologic(5;0.088)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TGCAGCAGCGGCTTGGCCGGG	0.682000													23	77					0	0	0.002780	0	0
POTEH	23784	broad.mit.edu	37	22	16267071	16267071	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:16267071C>T	ENST00000343518.6	-	9	1429	c.1378G>A	c.(1378-1380)Gga>Aga	p.G460R		NM_001136213.1	NP_001129685.1	Q6S545	POTEH_HUMAN	POTE ankyrin domain family, member H	460										NS(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(20)|ovary(1)|skin(7)|urinary_tract(2)	37						TGAGTACTTCCGTGCTTCTTC	0.363000													25	219					0	0	0.001786	0	0
C11orf63	79864	broad.mit.edu	37	11	122817290	122817290	+	Silent	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:122817290A>G	ENST00000227349.2	+	6	2016	c.1719A>G	c.(1717-1719)caA>caG	p.Q573Q	C11orf63_ENST00000531316.1_Silent_p.Q573Q	NM_024806.2	NP_079082.2	Q6NUN7	CK063_HUMAN	chromosome 11 open reading frame 63	573										breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(13)|lung(14)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)	47		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		AGCATCAGCAAGCCTTGGTGC	0.488000													27	2					0	0	0.003954	0	0
CSMD3	114788	broad.mit.edu	37	8	113364645	113364645	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:113364645C>T	ENST00000297405.5	-	39	6499	c.6255_splice	c.e39+1	p.Q2085_splice	CSMD3_ENST00000352409.3_Splice_Site_p.Q2015_splice|CSMD3_ENST00000343508.3_Splice_Site_p.Q2045_splice|CSMD3_ENST00000455883.2_Splice_Site_p.Q1981_splice	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	2085	Sushi 11.					integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATAGACTTACCTGAAGAGAAT	0.358000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			17	94					0	0	0.004990	0	0
HTRA4	203100	broad.mit.edu	37	8	38832575	38832575	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:38832575G>A	ENST00000302495.4	+	2	592	c.492G>A	c.(490-492)agG>agA	p.R164R		NM_153692.3	NP_710159.1	P83105	HTRA4_HUMAN	HtrA serine peptidase 4	164					proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(7)|upper_aerodigestive_tract(1)	11		all_lung(54;0.0344)|Hepatocellular(245;0.0512)|Lung NSC(58;0.0955)	LUSC - Lung squamous cell carcinoma(45;1.5e-07)			GCCCGCTCAGGAGGAATTACA	0.547000													49	166					0	0	0.003610	0	0
EML4	27436	broad.mit.edu	37	2	42531667	42531667	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:42531667T>G	ENST00000318522.5	+	17	2205	c.1943T>G	c.(1942-1944)gTg>gGg	p.V648G	EML4_ENST00000453191.2_5'UTR|EML4_ENST00000402711.2_Missense_Mutation_p.V590G|EML4_ENST00000401738.3_Missense_Mutation_p.V659G	NM_019063.3	NP_061936.2	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	648					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(543)	NS(2)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	12						GGCACAGTGGTGGCCATAGGA	0.468000			T	ALK	NSCLC								54	46					0	0	0.003610	0	0
MVD	4597	broad.mit.edu	37	16	88719738	88719738	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:88719738G>A	ENST00000301012.3	-	9	1121	c.1092C>T	c.(1090-1092)ccC>ccT	p.P364P		NM_002461.1	NP_002452.1	P53602	MVD1_HUMAN	mevalonate (diphospho) decarboxylase	364					cholesterol biosynthetic process|positive regulation of cell proliferation	cytosol	ATP binding|diphosphomevalonate decarboxylase activity|Hsp70 protein binding|kinase activity|protein homodimerization activity			endometrium(3)|large_intestine(1)|lung(7)|ovary(1)	12				BRCA - Breast invasive adenocarcinoma(80;0.0478)		TGACCCCACCGGGGGTCGGCT	0.667000													9	14					0	0	0.000673	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182491	57182491	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:57182491C>T	ENST00000504228.1	+	6	2928	c.2823C>T	c.(2821-2823)agC>agT	p.S941S	KIAA1211_ENST00000541073.1_Silent_p.S934S|KIAA1211_ENST00000264229.6_Silent_p.S941S			Q6ZU35	K1211_HUMAN	KIAA1211	941	Pro-rich.									endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CGGCCAGCAGCCAGACCCCGG	0.647000													6	30					0	0	0.001168	0	0
NOTCH4	4855	broad.mit.edu	37	6	32187406	32187406	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32187406C>T	ENST00000375023.3	-	8	1611	c.1473G>A	c.(1471-1473)ctG>ctA	p.L491L		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	491	EGF-like 12; calcium-binding (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						CAAGTAGGTCCAGACAGGTGC	0.592000													64	504					0	0	0.003610	0	0
ZHX3	23051	broad.mit.edu	37	20	39830930	39830930	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:39830930G>A	ENST00000309060.3	-	4	3042	c.2627C>T	c.(2626-2628)tCc>tTc	p.S876F	ZHX3_ENST00000432768.2_Missense_Mutation_p.S876F|ZHX3_ENST00000559234.1_Missense_Mutation_p.S876F|ZHX3_ENST00000558993.1_Intron|ZHX3_ENST00000557816.1_Intron|ZHX3_ENST00000560361.1_Missense_Mutation_p.S876F|ZHX3_ENST00000540170.1_Missense_Mutation_p.S876F|ZHX3_ENST00000544979.2_Missense_Mutation_p.S876F			Q9H4I2	ZHX3_HUMAN	zinc fingers and homeoboxes 3	876					negative regulation of transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			endometrium(2)|kidney(5)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	31		Myeloproliferative disorder(115;0.00425)				GACCTGCTGGGAGCTCATCTG	0.577000													45	120					0	0	0.002522	0	0
ZNF681	148213	broad.mit.edu	37	19	23926506	23926506	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:23926506T>A	ENST00000402377.3	-	4	1987	c.1846A>T	c.(1846-1848)Aaa>Taa	p.K616*	ZNF681_ENST00000395385.3_Nonsense_Mutation_p.K547*	NM_138286.2	NP_612143.2	Q96N22	ZN681_HUMAN	zinc finger protein 681	616					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(10)|prostate(1)|skin(1)|urinary_tract(3)	21		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				TTGTAGAGTTTCTCACCAGTA	0.328000													5	4					0	0	0.000602	0	0
PXDN	7837	broad.mit.edu	37	2	1653160	1653160	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:1653160C>T	ENST00000252804.4	-	17	2442	c.2392G>A	c.(2392-2394)Gtg>Atg	p.V798M		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	798					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		GTGGTGGACACCAGGCGCGGC	0.637000													17	52					0	0	0.004990	0	0
UBR2	23304	broad.mit.edu	37	6	42582840	42582840	+	Silent	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:42582840T>C	ENST00000372899.1	+	9	1275	c.1017T>C	c.(1015-1017)ggT>ggC	p.G339G	UBR2_ENST00000372903.2_Silent_p.G339G|UBR2_ENST00000372901.1_Silent_p.G339G	NM_015255.2	NP_056070.1	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2	339					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			GTCAAGTTGGTTTACAAGAAG	0.353000													39	139					0	0	0.003214	0	0
EI24	9538	broad.mit.edu	37	11	125448111	125448111	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:125448111C>T	ENST00000278903.6	+	6	641	c.399C>T	c.(397-399)ccC>ccT	p.P133P	STT3A-AS1_ENST00000532714.1_RNA|STT3A-AS1_ENST00000530526.1_RNA|EI24_ENST00000343678.4_Silent_p.P133P|EI24_ENST00000530985.1_3'UTR	NM_004879.3	NP_004870.3	O14681	EI24_HUMAN	etoposide induced 2.4	133					apoptosis|autophagy|induction of apoptosis|negative regulation of cell growth	endoplasmic reticulum membrane|integral to membrane|nuclear membrane				large_intestine(1)|lung(9)|ovary(1)	11	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.64e-07)|OV - Ovarian serous cystadenocarcinoma(99;0.0975)		GGGTGCTCCCCTTGTTTGTGC	0.498000													50	60					0	0	0.003610	0	0
ZNF470	388566	broad.mit.edu	37	19	57088341	57088341	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57088341C>T	ENST00000330619.8	+	6	1230	c.544C>T	c.(544-546)Cat>Tat	p.H182Y	ZNF470_ENST00000601902.1_Intron|ZNF470_ENST00000391709.3_Missense_Mutation_p.H182Y	NM_001001668.3	NP_001001668.3	Q6ECI4	ZN470_HUMAN	zinc finger protein 470	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(7)|large_intestine(12)|lung(11)|ovary(1)|pancreas(3)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	41		Colorectal(82;5.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0294)		GACAGTTTTTCATCTGAATAC	0.303000													16	37					0	0	0.003163	0	0
PLOD1	5351	broad.mit.edu	37	1	12017929	12017929	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:12017929C>T	ENST00000196061.4	+	8	799	c.772C>T	c.(772-774)Ccg>Tcg	p.P258S	PLOD1_ENST00000485046.1_3'UTR|PLOD1_ENST00000376369.3_Missense_Mutation_p.P305S	NM_000302.3	NP_000293.2	Q02809	PLOD1_HUMAN	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1	258					epidermis development|hydroxylysine biosynthetic process|protein modification process|response to hypoxia	rough endoplasmic reticulum membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-lysine 5-dioxygenase activity|protein homodimerization activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(15)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	29	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.06e-06)|COAD - Colon adenocarcinoma(227;0.000273)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.000809)|KIRC - Kidney renal clear cell carcinoma(229;0.00267)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)	Minoxidil(DB00350)|Succinic acid(DB00139)|Vitamin C(DB00126)	CAACTACATCCCGCGCTTCTG	0.627000													16	77					0	0	0.001882	0	0
ABCG1	9619	broad.mit.edu	37	21	43711712	43711712	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:43711712C>T	ENST00000398437.1	+	14	2221	c.2073C>T	c.(2071-2073)tcC>tcT	p.S691S	ABCG1_ENST00000462050.1_3'UTR|ABCG1_ENST00000343687.3_Silent_p.S544S|ABCG1_ENST00000361802.2_Silent_p.S545S|ABCG1_ENST00000347800.2_Silent_p.S530S|ABCG1_ENST00000340588.4_Silent_p.S653S|ABCG1_ENST00000398449.3_Silent_p.S533S|ABCG1_ENST00000398457.2_Silent_p.S535S			P45844	ABCG1_HUMAN	ATP-binding cassette, sub-family G (WHITE), member 1	545					amyloid precursor protein catabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|detection of hormone stimulus|high-density lipoprotein particle remodeling|intracellular cholesterol transport|lipoprotein metabolic process|low-density lipoprotein particle remodeling|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|positive regulation of cholesterol biosynthetic process|regulation of cholesterol esterification|regulation of transcription, DNA-dependent|response to lipid|reverse cholesterol transport	endoplasmic reticulum membrane|external side of plasma membrane|Golgi membrane|recycling endosome	ADP binding|ATP binding|cholesterol transporter activity|glycoprotein transporter activity|phospholipid transporter activity|protein heterodimerization activity|protein homodimerization activity|sterol-transporting ATPase activity|toxin transporter activity			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(6)|ovary(3)|prostate(2)|stomach(1)	29					Adenosine triphosphate(DB00171)	CCATGACCTCCCTGGTGGCAC	0.662000													7	9					0	0	0.001984	0	0
FTSJ2	29960	broad.mit.edu	37	7	2274925	2274925	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:2274925G>A	ENST00000242257.8	-	3	601	c.573C>T	c.(571-573)ttC>ttT	p.F191F	FTSJ2_ENST00000407040.1_Silent_p.F97F|FTSJ2_ENST00000440306.2_3'UTR|FTSJ2_ENST00000486040.1_5'UTR	NM_013393.1	NP_037525.1	Q9UI43	RRMJ2_HUMAN	FtsJ RNA methyltransferase homolog 2 (E. coli)	191					cell proliferation	mitochondrion|nucleolus	nucleic acid binding|rRNA (uridine-2'-O-)-methyltransferase activity			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	12		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0822)|OV - Ovarian serous cystadenocarcinoma(56;2.7e-14)		TTTTACAAAGGAATGTCCCCC	0.542000													13	153					0	0	0.002450	0	0
ATP2B1	490	broad.mit.edu	37	12	90010769	90010769	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:90010769G>A	ENST00000428670.3	-	12	2333	c.1877C>T	c.(1876-1878)cCa>cTa	p.P626L	ATP2B1_ENST00000348959.3_Missense_Mutation_p.P626L|ATP2B1_ENST00000359142.3_Missense_Mutation_p.P626L|ATP2B1_ENST00000393164.2_Missense_Mutation_p.P369L|ATP2B1_ENST00000261173.2_Missense_Mutation_p.P626L			P20020	AT2B1_HUMAN	ATPase, Ca++ transporting, plasma membrane 1	626					ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(3)|large_intestine(13)|lung(15)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	45						ACGGTCCCTTGGTCTGAATAC	0.358000													27	83					0	0	0.004656	0	0
DENND4C	55667	broad.mit.edu	37	9	19342634	19342634	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:19342634T>G	ENST00000307015.9	+	18	2333	c.581T>G	c.(580-582)gTg>gGg	p.V194G	DENND4C_ENST00000602925.1_Missense_Mutation_p.V954G|DENND4C_ENST00000434457.2_Missense_Mutation_p.V1003G|DENND4C_ENST00000380432.2_Missense_Mutation_p.V718G|DENND4C_ENST00000540671.1_Missense_Mutation_p.V48G			Q5VZ89	DEN4C_HUMAN	DENN/MADD domain containing 4C	718	DENN.					integral to membrane				breast(1)|endometrium(8)|kidney(1)|large_intestine(7)|liver(2)|lung(13)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	40						TTTCCAGAGGTGTGTGATGCC	0.378000													27	33					0	0	0.001512	0	0
PTCHD2	57540	broad.mit.edu	37	1	11561714	11561714	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:11561714G>A	ENST00000294484.6	+	2	803	c.665G>A	c.(664-666)cGa>cAa	p.R222Q	PTCHD2_ENST00000389575.3_Missense_Mutation_p.R222Q	NM_020780.1	NP_065831.1	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	222					cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity	p.R439Q(1)		NS(3)|breast(2)|endometrium(9)|kidney(4)|large_intestine(5)|lung(34)|ovary(3)|pancreas(1)|prostate(6)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	76	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		GAAGACCCGCGAAACCAGCGG	0.692000													5	19					0	0	0.001168	0	0
DNAL1	83544	broad.mit.edu	37	14	74125555	74125555	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:74125555G>A	ENST00000553645.1	+	3	89	c.48G>A	c.(46-48)gaG>gaA	p.E16E	DNAL1_ENST00000554339.1_Intron|DNAL1_ENST00000540526.1_5'UTR|DNAL1_ENST00000311089.3_Intron|DNAL1_ENST00000554871.1_5'UTR	NM_031427.3	NP_113615.2	Q4LDG9	DNAL1_HUMAN	dynein, axonemal, light chain 1	16										kidney(1)|lung(2)	3				BRCA - Breast invasive adenocarcinoma(234;0.00384)|KIRC - Kidney renal clear cell carcinoma(182;0.095)		CATAGGAAGAGAAAACTGGCC	0.393000													44	69					0	0	0.001951	0	0
GPR148	344561	broad.mit.edu	37	2	131487717	131487717	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:131487717C>T	ENST00000309926.4	+	1	1075	c.993C>T	c.(991-993)gtC>gtT	p.V331V		NM_207364.2	NP_997247.2	Q8TDV2	GP148_HUMAN	G protein-coupled receptor 148	331						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(15)|skin(3)|upper_aerodigestive_tract(1)	27	Colorectal(110;0.1)					TGGGCATGGTCCGGGGCCACC	0.547000													7	14					0	0	0.001984	0	0
ACTL9	284382	broad.mit.edu	37	19	8808449	8808449	+	Silent	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:8808449C>A	ENST00000324436.3	-	1	723	c.603G>T	c.(601-603)ggG>ggT	p.G201G		NM_178525.3	NP_848620.2	Q8TC94	ACTL9_HUMAN	actin-like 9	201						cytoplasm|cytoskeleton				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(8)|lung(15)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	36						TGTAGGTGACCCCGTGTCCCG	0.667000													11	18					1.58986e-06	2.70243e-06	0.000673	1	0
NOTCH4	4855	broad.mit.edu	37	6	32185012	32185012	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32185012G>A	ENST00000375023.3	-	10	1794	c.1656C>T	c.(1654-1656)atC>atT	p.I552I		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	552	EGF-like 14; calcium-binding (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						TGCACTCATCGATATCCTCCT	0.622000													78	418					0	0	0.003610	0	0
OR8J1	219477	broad.mit.edu	37	11	56128658	56128658	+	Silent	SNP	C	C	T	rs148720229		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:56128658C>T	ENST00000303039.3	+	1	968	c.936C>T	c.(934-936)tcC>tcT	p.S312S		NM_001005205.2	NP_001005205.2	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J, member 1	312					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S312S(1)		breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	47	Esophageal squamous(21;0.00448)					TGTGCTATTCCTTTAAAACAA	0.353000													12	105					0	0	0.000978	0	0
CTBP1-AS2	92070	broad.mit.edu	37	4	1244873	1244873	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:1244873C>T	ENST00000581398.1	+	0	827				CTBP1-AS2_ENST00000357591.2_RNA|CTBP1-AS2_ENST00000578730.1_RNA|CTBP1-AS2_ENST00000514984.1_RNA	NR_033339.1																						TCCATGGCCTCCGTCTACACA	0.587000													9	73					0	0	0.000978	0	0
C6orf15	29113	broad.mit.edu	37	6	31079679	31079679	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31079679C>T	ENST00000259870.3	-	2	460	c.457G>A	c.(457-459)Ggg>Agg	p.G153R		NM_014070.2	NP_054789.2	Q6UXA7	CF015_HUMAN	chromosome 6 open reading frame 15	153										endometrium(3)|large_intestine(2)|lung(9)|prostate(1)|skin(1)|stomach(1)	17						GAAGACTCCCCAGGCAAAGGG	0.647000													17	134					0	0	0.004990	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57080341	57080341	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57080341G>A	ENST00000532437.1	-	4	2132	c.1821C>T	c.(1819-1821)acC>acT	p.T607T	TNKS1BP1_ENST00000358252.3_Silent_p.T607T			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	607	Acidic.|Pro-rich.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				CTGCCTCCCTGGTAGCCAGGG	0.637000													20	65					0	0	0.002780	0	0
ATP10D	57205	broad.mit.edu	37	4	47527602	47527602	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:47527602C>T	ENST00000273859.3	+	5	988	c.719C>T	c.(718-720)tCc>tTc	p.S240F	ATP10D_ENST00000504445.1_Missense_Mutation_p.S240F	NM_020453.3	NP_065186.3	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	240					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						GAGAAGTTTTCCAGTAGGATA	0.353000													10	73					0	0	0.006214	0	0
ICK	22858	broad.mit.edu	37	6	52869951	52869951	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:52869951C>T	ENST00000356971.3	-	15	2384	c.1895G>A	c.(1894-1896)cGa>cAa	p.R632Q	ICK_ENST00000350082.5_Missense_Mutation_p.R632Q	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	632					intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					AGACAGTCATCGCCGAGATGC	0.567000													27	161					0	0	0.001786	0	0
NOS1	4842	broad.mit.edu	37	12	117768218	117768218	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:117768218C>T	ENST00000317775.6	-	2	1342	c.657G>A	c.(655-657)ggG>ggA	p.G219G	NOS1_ENST00000344089.3_Silent_p.G219G|NOS1_ENST00000338101.4_Silent_p.G219G	NM_000620.4|NM_001204218.1	NP_000611.1|NP_001191147.1	P29475	NOS1_HUMAN	nitric oxide synthase 1 (neuronal)	219	PIN (nNOS-inhibiting protein) binding.				multicellular organismal response to stress|myoblast fusion|negative regulation of calcium ion transport into cytosol|neurotransmitter biosynthetic process|nitric oxide biosynthetic process|platelet activation|positive regulation of vasodilation|regulation of cardiac muscle contraction|response to heat|response to hypoxia	cytoskeleton|cytosol|dendritic spine|perinuclear region of cytoplasm|photoreceptor inner segment|sarcolemma|sarcoplasmic reticulum	arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			NS(1)|breast(1)|central_nervous_system(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(17)|large_intestine(21)|lung(43)|ovary(3)|pancreas(1)|prostate(6)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	117	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.0561)	L-Citrulline(DB00155)	CCCCTCTGCTCCCACTGGTGA	0.567000													45	95					0	0	0.003610	0	0
GXYLT2	727936	broad.mit.edu	37	3	73006469	73006469	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:73006469G>A	ENST00000389617.4	+	5	1103	c.942G>A	c.(940-942)caG>caA	p.Q314Q		NM_001080393.1	NP_001073862.1	A0PJZ3	GXLT2_HUMAN	glucoside xylosyltransferase 2	314					O-glycan processing	integral to membrane	UDP-xylosyltransferase activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(6)|upper_aerodigestive_tract(1)|urinary_tract(3)	18						GGGGAGACCAGGatttattaa	0.443000													8	22					0	0	0.004482	0	0
DICER1	23405	broad.mit.edu	37	14	95570308	95570308	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:95570308G>A	ENST00000526495.1	-	23	3716	c.3425C>T	c.(3424-3426)tCt>tTt	p.S1142F	DICER1_ENST00000393063.1_Missense_Mutation_p.S1142F|DICER1_ENST00000556045.1_Missense_Mutation_p.S40F|DICER1_ENST00000343455.3_Missense_Mutation_p.S1142F|DICER1_ENST00000541352.1_Missense_Mutation_p.S1142F|DICER1_ENST00000527414.1_Missense_Mutation_p.S1142F			Q9UPY3	DICER_HUMAN	dicer 1, ribonuclease type III	1142					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(13)|kidney(3)|large_intestine(10)|lung(33)|ovary(1)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)	75		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		ATTTTCTAGAGAGGAGGTTCT	0.423000			"""Mis F, N"""		"""sex cord-stromal tumour, TGCT, embryonal rhadomyosarcoma"""	pleuropulmonary blastoma			Familial Multinodular Goiter ;DICER 1 syndrome				16	23					0	0	0.003163	0	0
DSP	1832	broad.mit.edu	37	6	7579632	7579632	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:7579632C>T	ENST00000379802.3	+	23	3550	c.3209C>T	c.(3208-3210)tCc>tTc	p.S1070F	DSP_ENST00000418664.2_Missense_Mutation_p.S1070F	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	1070	Central fibrous rod domain.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		GCAGAGTGTTCCCAGTTCAAA	0.507000													24	100					0	0	0.003954	0	0
TBC1D3P5	440419	broad.mit.edu	37	17	25753503	25753503	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:25753503C>T	ENST00000586223.1	+	0	1513					NR_033892.1																						TCGGGCTCACCCCGTGCCTGT	0.567000													26	10					0	0	0.001786	0	0
PTPN14	5784	broad.mit.edu	37	1	214556883	214556883	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:214556883G>A	ENST00000366956.5	-	13	2509	c.2315C>T	c.(2314-2316)cCt>cTt	p.P772L	PTPN14_ENST00000543945.1_3'UTR	NM_005401.4	NP_005392.2	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type 14	772					lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			NS(2)|breast(3)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(9)|liver(3)|lung(21)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	58				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		CATGGCGGGAGGAAGGCTGGC	0.682000													7	43					0	0	0.003080	0	0
MAVS	57506	broad.mit.edu	37	20	3846674	3846674	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:3846674C>T	ENST00000428216.2	+	7	1631	c.1503C>T	c.(1501-1503)ttC>ttT	p.F501F	MAVS_ENST00000416600.2_Silent_p.F360F|MAVS_ENST00000358134.6_3'UTR	NM_020746.4	NP_065797.2	Q7Z434	MAVS_HUMAN	mitochondrial antiviral signaling protein	501					activation of innate immune response|cellular response to exogenous dsRNA|defense response to bacterium|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of chemokine (C-C motif) ligand 5 production|positive regulation of defense response to virus by host|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interleukin-8 production|positive regulation of IP-10 production|positive regulation of protein import into nucleus, translocation|positive regulation of protein phosphorylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription factor import into nucleus|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of type I interferon-mediated signaling pathway|response to virus	integral to membrane|mitochondrial outer membrane	CARD domain binding|protein kinase binding|signal transducer activity			autonomic_ganglia(1)|breast(3)|endometrium(1)|large_intestine(3)|lung(4)|skin(1)|upper_aerodigestive_tract(1)	14						ACCGGAAGTTCCAGGAGAGGG	0.672000													13	43					0	0	0.001855	0	0
PSG5	5673	broad.mit.edu	37	19	43683301	43683301	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:43683301G>A	ENST00000599812.1	-	3	534	c.439C>T	c.(439-441)Ccc>Tcc	p.P147S	PSG5_ENST00000342951.6_Intron|PSG5_ENST00000407356.1_Intron|PSG5_ENST00000366175.3_Intron|PSG5_ENST00000407568.1_Intron|PSG5_ENST00000404580.1_Intron			Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	147	Ig-like C2-type 1.				female pregnancy	extracellular region				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(18)|prostate(1)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		Prostate(69;0.00899)				GAGGGCTTGGGAGTTTCCACT	0.507000													48	118					0	0	0.003610	0	0
CD163	9332	broad.mit.edu	37	12	7653749	7653749	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:7653749C>T	ENST00000359156.4	-	3	645	c.443G>A	c.(442-444)gGa>gAa	p.G148E	CD163_ENST00000541972.1_Missense_Mutation_p.G136E|CD163_ENST00000432237.2_Missense_Mutation_p.G148E|CD163_ENST00000396620.3_Missense_Mutation_p.G148E	NM_004244.5	NP_004235.4	Q86VB7	C163A_HUMAN	CD163 molecule	148	SRCR 1.				acute-phase response	extracellular region|integral to plasma membrane	protein binding|scavenger receptor activity			breast(1)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(6)|pancreas(2)|prostate(1)|skin(5)|urinary_tract(4)	76						GCAGGTCACTCCAGCATCTTG	0.423000													56	105					0	0	0.003610	0	0
COL23A1	91522	broad.mit.edu	37	5	177683400	177683400	+	Splice_Site	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:177683400T>G	ENST00000390654.3	-	15	1195		c.e15-2		COL23A1_ENST00000407622.1_Splice_Site	NM_173465.3	NP_775736.2	Q86Y22	CONA1_HUMAN	collagen, type XXIII, alpha 1							collagen|integral to membrane|plasma membrane	protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(3)|lung(6)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(89;0.00188)|Renal(175;0.000159)|Lung NSC(126;0.00814)|all_lung(126;0.0129)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	OV - Ovarian serous cystadenocarcinoma(192;0.153)|all cancers(165;0.172)		AGGCTCCCCCTGTGGAGACAT	0.672000													13	19					0	0	0.006122	0	0
NLRP8	126205	broad.mit.edu	37	19	56467422	56467422	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:56467422C>T	ENST00000291971.3	+	3	2069	c.1998C>T	c.(1996-1998)ttC>ttT	p.F666F	NLRP8_ENST00000590542.1_Silent_p.F666F	NM_176811.2	NP_789781.2	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	666						cytoplasm	ATP binding			breast(4)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(14)|ovary(5)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	35		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CCCTGAACTTCATGAACGTGT	0.517000													21	64					0	0	0.001523	0	0
SLC7A9	11136	broad.mit.edu	37	19	33359359	33359359	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:33359359T>G	ENST00000023064.4	-	2	273	c.82A>C	c.(82-84)Aag>Cag	p.K28Q	SLC7A9_ENST00000587772.1_Missense_Mutation_p.K28Q|SLC7A9_ENST00000590341.1_Missense_Mutation_p.K28Q	NM_001126335.1|NM_001243036.1|NM_014270.4	NP_001119807.1|NP_001229965.1|NP_055085.1	P82251	BAT1_HUMAN	solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9	28					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	integral to plasma membrane	L-cystine transmembrane transporter activity|neutral amino acid transmembrane transporter activity|peptide antigen binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(12)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	32	Esophageal squamous(110;0.137)				L-Cystine(DB00138)	CTTACCTCCTTTTGGAGACTG	0.592000													6	44					0	0	0.003080	0	0
SLC9A2	6549	broad.mit.edu	37	2	103311508	103311508	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:103311508G>A	ENST00000233969.2	+	7	1664	c.1522G>A	c.(1522-1524)Gat>Aat	p.D508N	SLC9A2_ENST00000469286.1_3'UTR	NM_003048.3	NP_003039.2	Q9UBY0	SL9A2_HUMAN	solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2	508						integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(5)|central_nervous_system(3)|endometrium(3)|kidney(1)|large_intestine(3)|lung(17)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42						TTAGTTGTTTGATCATGTGAA	0.363000													32	46					0	0	0.001786	0	0
HIVEP2	3097	broad.mit.edu	37	6	143074685	143074685	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:143074685G>A	ENST00000367603.2	-	10	7642	c.6900C>T	c.(6898-6900)tcC>tcT	p.S2300S	HIVEP2_ENST00000012134.2_Silent_p.S2300S|HIVEP2_ENST00000367604.1_Silent_p.S2300S|RP1-67K17.3_ENST00000437067.1_RNA	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	2300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		GCCGAGGAGAGGAGGGAGTGC	0.517000													23	40					0	0	0.004656	0	0
WBP11P1	441818	broad.mit.edu	37	18	30091802	30091802	+	RNA	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:30091802T>G	ENST00000567636.1	+	0	177					NR_003558.1																						AATGAACAAGTAAACCATACA	0.438000													25	25					0	0	0.003330	0	0
RALBP1	10928	broad.mit.edu	37	18	9533743	9533743	+	Silent	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:9533743C>A	ENST00000019317.4	+	9	1843	c.1620C>A	c.(1618-1620)tcC>tcA	p.S540S	RALBP1_ENST00000383432.3_Silent_p.S540S			Q15311	RBP1_HUMAN	ralA binding protein 1	540					chemotaxis|positive regulation of Cdc42 GTPase activity|small GTPase mediated signal transduction|transport	cytosol|membrane	ATPase activity, coupled to movement of substances|Rac GTPase activator activity|Rac GTPase binding|Ral GTPase binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(3)|upper_aerodigestive_tract(1)	14						AGTACTCCTCCGAGAGCGAGA	0.527000													25	53					2.24059e-21	3.83337e-21	0.006320	1	0
TMEM52B	120939	broad.mit.edu	37	12	10339122	10339122	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:10339122C>T	ENST00000298530.3	+	3	759	c.181C>T	c.(181-183)Cca>Tca	p.P61S	TMEM52B_ENST00000536952.1_Missense_Mutation_p.P81S|TMEM52B_ENST00000381923.2_Missense_Mutation_p.P81S	NM_153022.2	NP_694567.1			transmembrane protein 52B																		AGATGGGGGCCCACCACCCTG	0.562000													29	38					0	0	0.006320	0	0
TFEB	7942	broad.mit.edu	37	6	41654886	41654886	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:41654886T>C	ENST00000394283.1	-	7	1975	c.749A>G	c.(748-750)aAc>aGc	p.N250S	TFEB_ENST00000403298.4_Missense_Mutation_p.N250S|TFEB_ENST00000358871.2_Missense_Mutation_p.N264S|TFEB_ENST00000420312.1_Missense_Mutation_p.N165S|TFEB_ENST00000230323.4_Missense_Mutation_p.N250S|TFEB_ENST00000373033.1_Missense_Mutation_p.N250S			P19484	TFEB_HUMAN	transcription factor EB	250	Helix-loop-helix motif.				embryonic placenta development|humoral immune response|positive regulation of transcription from RNA polymerase II promoter	cytoplasm	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)	11	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;7.61e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			GTCATTGATGTTGAACCTTCG	0.557000			T	ALPHA	renal (childhood epithelioid)								12	80					0	0	0.003163	0	0
ATF6B	1388	broad.mit.edu	37	6	32093947	32093947	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32093947G>A	ENST00000375201.4	-	5	461	c.416C>T	c.(415-417)tCc>tTc	p.S139F	ATF6B_ENST00000468502.1_5'UTR|ATF6B_ENST00000375203.3_Missense_Mutation_p.S142F			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	142					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						TTCAAATGAGGATGTTGGGTC	0.532000													200	1073					0	0	0.003610	0	0
ZNF496	84838	broad.mit.edu	37	1	247463992	247463992	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:247463992G>A	ENST00000294753.4	-	9	2057	c.1593C>T	c.(1591-1593)ttC>ttT	p.F531F	ZNF496_ENST00000366498.2_Silent_p.F567F|ZNF496_ENST00000462139.1_5'UTR	NM_032752.1	NP_116141.1	Q96IT1	ZN496_HUMAN	zinc finger protein 496	531					positive regulation of transcription, DNA-dependent|viral reproduction		DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	36	all_cancers(71;0.000136)|all_epithelial(71;2.62e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0607)|Lung NSC(105;0.0661)		OV - Ovarian serous cystadenocarcinoma(106;0.00703)			CGTGCCGCTGGAAGGCCTTCC	0.627000													88	38					0	0	0.003610	0	0
CDH1	999	broad.mit.edu	37	16	68847364	68847364	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:68847364C>T	ENST00000261769.5	+	9	1477	c.1286C>T	c.(1285-1287)cCa>cTa	p.P429L	CDH1_ENST00000422392.2_Intron|CDH1_ENST00000562836.1_3'UTR	NM_004360.3	NP_004351.1	P12830	CADH1_HUMAN	cadherin 1, type 1, E-cadherin (epithelial)	429	Cadherin 3.				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.Y380_K440del(2)|p.?(1)		NS(6)|biliary_tract(8)|breast(161)|central_nervous_system(4)|endometrium(9)|kidney(4)|large_intestine(13)|lung(13)|oesophagus(3)|ovary(2)|prostate(3)|soft_tissue(2)|stomach(76)|thyroid(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	311		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		ACCACAAATCCAGTGAACAAC	0.473000			"""Mis, N, F, S"""		"""lobular breast, gastric"""	gastric			Hereditary Diffuse Gastric Cancer				52	165					0	0	0.003610	0	0
OS9	10956	broad.mit.edu	37	12	58113946	58113946	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:58113946G>A	ENST00000315970.7	+	13	1706	c.1665G>A	c.(1663-1665)caG>caA	p.Q555Q	OS9_ENST00000413095.2_Intron|OS9_ENST00000389142.5_Intron|OS9_ENST00000551035.1_Intron|RP11-571M6.7_ENST00000549477.1_RNA|OS9_ENST00000435406.2_Intron|OS9_ENST00000257966.8_Intron|OS9_ENST00000389146.6_Silent_p.Q540Q|OS9_ENST00000439210.2_Intron|OS9_ENST00000552285.1_Intron	NM_001017958.2|NM_006812.3	NP_001017958.1|NP_006803.1	Q13438	OS9_HUMAN	osteosarcoma amplified 9, endoplasmic reticulum lectin	555					ER-associated protein catabolic process|protein retention in ER lumen|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to endoplasmic reticulum stress	endoplasmic reticulum lumen|Hrd1p ubiquitin ligase complex	glycoprotein binding|protein binding|sugar binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|large_intestine(4)|lung(8)|ovary(2)|prostate(1)|urinary_tract(1)	21	all_neural(12;0.00548)|Glioma(12;0.0126)|Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			GCCCTAATCAGGATCTGACTG	0.577000													46	71					0	0	0.003214	0	0
P2RX7	5027	broad.mit.edu	37	12	121605372	121605372	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:121605372C>T	ENST00000328963.5	+	7	770	c.316C>T	c.(316-318)Cgt>Tgt	p.R106C	P2RX7_ENST00000443520.3_3'UTR|P2RX7_ENST00000535250.1_Missense_Mutation_p.R186C|P2RX7_ENST00000377162.2_Intron|P2RX7_ENST00000546057.1_Missense_Mutation_p.R276C|P2RX7_ENST00000541446.1_Intron			A8K2Z0	A8K2Z0_HUMAN	purinergic receptor P2X, ligand-gated ion channel, 7	276						integral to membrane	ATP binding|ion channel activity|receptor activity			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|lung(9)|skin(1)|stomach(1)	19	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ATACAGTTTCCGTCGCCTTGA	0.527000													88	257					0	0	0.003610	0	0
PEG3	5178	broad.mit.edu	37	19	57334191	57334191	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57334191C>T	ENST00000326441.9	-	6	858	c.495G>A	c.(493-495)tgG>tgA	p.W165*	ZIM2_ENST00000593931.1_Nonsense_Mutation_p.W40*|PEG3_ENST00000593695.1_Nonsense_Mutation_p.W39*|PEG3_ENST00000423103.2_Nonsense_Mutation_p.W165*|ZIM2_ENST00000599935.1_Nonsense_Mutation_p.W40*|ZIM2_ENST00000593711.1_Nonsense_Mutation_p.W40*|ZIM2_ENST00000601070.1_Nonsense_Mutation_p.W40*|ZIM2_ENST00000391708.3_Nonsense_Mutation_p.W40*|ZIM2_ENST00000221722.5_Nonsense_Mutation_p.W40*|PEG3_ENST00000598410.1_Nonsense_Mutation_p.W40*	NM_006210.2	NP_006201.1	Q9GZU2	PEG3_HUMAN	paternally expressed 3	165					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|biliary_tract(4)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(27)|lung(84)|ovary(8)|pancreas(5)|prostate(6)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)	170		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CCCTCCGGTCCCAGTCCCGGT	0.537000													10	9					0	0	0.006214	0	0
KCNH3	23416	broad.mit.edu	37	12	49951630	49951630	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:49951630G>A	ENST00000257981.6	+	15	3406	c.3146G>A	c.(3145-3147)gGg>gAg	p.G1049E		NM_012284.1	NP_036416.1	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 3	1049	Pro-rich.				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity			NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(20)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	36						CCAGGGTCAGGGGGCCTGGCC	0.667000													6	25					0	0	0.003080	0	0
COL28A1	340267	broad.mit.edu	37	7	7472283	7472283	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:7472283C>T	ENST00000399429.3	-	24	2049	c.1909G>A	c.(1909-1911)Gat>Aat	p.D637N		NM_001037763.2	NP_001032852.2	Q2UY09	COSA1_HUMAN	collagen, type XXVIII, alpha 1	637					cell adhesion	basement membrane|collagen	serine-type endopeptidase inhibitor activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(23)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	42		Ovarian(82;0.0789)		UCEC - Uterine corpus endometrioid carcinoma (126;0.228)		GGATAGCCATCACCTTTGAGT	0.493000													15	272					0	0	0.006122	0	0
KRT6C	286887	broad.mit.edu	37	12	52864331	52864331	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:52864331C>T	ENST00000252250.6	-	6	1208	c.1161G>A	c.(1159-1161)atG>atA	p.M387I		NM_173086.4	NP_775109.2	P48668	K2C6C_HUMAN	keratin 6C	387	Coil 2.|Rod.				cytoskeleton organization	keratin filament	structural molecule activity			cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|lung(6)|ovary(3)|prostate(2)|skin(2)	23				BRCA - Breast invasive adenocarcinoma(357;0.0828)		GCCTCTGGATCATGCGGTTGA	0.547000													24	77					0	0	0.005443	0	0
MARCH11	441061	broad.mit.edu	37	5	16091132	16091132	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:16091132C>T	ENST00000332432.8	-	3	951	c.752G>A	c.(751-753)gGa>gAa	p.G251E	MARCH11_ENST00000505509.1_5'UTR	NM_001102562.1	NP_001096032.1	A6NNE9	MARHB_HUMAN	membrane-associated ring finger (C3HC4) 11	251						cytoplasmic vesicle membrane|integral to membrane	ligase activity|zinc ion binding			NS(1)|central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(14)|urinary_tract(1)	20						GAACAGGGATCCTAGGATTAC	0.443000													13	9					0	0	0.001368	0	0
HMGXB4	10042	broad.mit.edu	37	22	35661516	35661516	+	Missense_Mutation	SNP	C	C	T	rs28522155		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:35661516C>T	ENST00000216106.5	+	5	1263	c.1135C>T	c.(1135-1137)Cct>Tct	p.P379S	HMGXB4_ENST00000444518.2_Missense_Mutation_p.P270S	NM_001003681.2	NP_001003681.1	Q9UGU5	HMGX4_HUMAN	HMG box domain containing 4	379					endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|endometrium(1)|large_intestine(6)|liver(1)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						CCTGCCACTTCCTGGCCTCCA	0.498000													15	40					0	0	0.003163	0	0
TUBGCP3	10426	broad.mit.edu	37	13	113208409	113208409	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:113208409G>A	ENST00000261965.3	-	8	1114	c.928C>T	c.(928-930)Cag>Tag	p.Q310*	TUBGCP3_ENST00000375669.3_Nonsense_Mutation_p.Q310*	NM_006322.4	NP_006313.1	Q96CW5	GCP3_HUMAN	tubulin, gamma complex associated protein 3	310					G2/M transition of mitotic cell cycle|microtubule nucleation|single fertilization	centriole|cytosol|polar microtubule	gamma-tubulin binding|structural constituent of cytoskeleton			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(9)|prostate(3)|urinary_tract(1)	25	all_lung(23;0.000374)|Lung NSC(43;0.0107)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)					AGGCTCCTCTGGTCCGTGTAT	0.483000													23	48					0	0	0.003330	0	0
ZNF676	163223	broad.mit.edu	37	19	22363614	22363614	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:22363614A>G	ENST00000397121.2	-	3	1222	c.905T>C	c.(904-906)aTt>aCt	p.I302T		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	302					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TCCAGTATGAATTCTCTTATG	0.428000													17	33					0	0	0.001523	0	0
KAAG1	353219	broad.mit.edu	37	6	24358102	24358102	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:24358102C>T	ENST00000274766.1	+	1	972	c.235C>T	c.(235-237)Cca>Tca	p.P79S	DCDC2_ENST00000378454.3_5'UTR	NM_181337.3	NP_851854.1	Q9UBP8	KAAG1_HUMAN	kidney associated antigen 1	79					immune response					central_nervous_system(1)|lung(1)|prostate(1)	3						ACTGACGAATCCACAGGTGAA	0.622000													12	48					0	0	0.002450	0	0
LRP5	4041	broad.mit.edu	37	11	68115509	68115509	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:68115509G>A	ENST00000294304.7	+	2	392	c.286G>A	c.(286-288)Ggg>Agg	p.G96R		NM_002335.2	NP_002326.2	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein 5	96	Beta-propeller 1.				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			autonomic_ganglia(1)|breast(3)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(24)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						GAACCAGACGGGGGCCGCCGT	0.637000													73	91					0	0	0.003610	0	0
SLC15A2	6565	broad.mit.edu	37	3	121613338	121613338	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:121613338G>A	ENST00000489711.1	+	1	403	c.15G>A	c.(13-15)caG>caA	p.Q5Q	SLC15A2_ENST00000295605.2_Silent_p.Q5Q	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	5					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	ATCCTTTCCAGAAAAATGAGT	0.488000													42	102					0	0	0.002222	0	0
HIST1H1T	3010	broad.mit.edu	37	6	26108188	26108188	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:26108188G>A	ENST00000338379.4	-	1	176	c.134C>T	c.(133-135)tCc>tTc	p.S45F		NM_005323.3	NP_005314.2	P22492	H1T_HUMAN	histone cluster 1, H1t	45	H15.				cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			breast(2)|endometrium(1)|lung(3)|ovary(2)|prostate(1)	9						GATCAACTTGGACACAGAGAG	0.547000													15	114					0	0	0.004007	0	0
NSG1	27065	broad.mit.edu	37	4	4411407	4411407	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:4411407C>T	ENST00000421177.2	+	8	2345	c.354C>T	c.(352-354)ctC>ctT	p.L118L	NSG1_ENST00000433139.2_Silent_p.L118L|NSG1_ENST00000504171.1_Silent_p.L79L|NSG1_ENST00000505246.1_Silent_p.L118L|NSG1_ENST00000506380.1_Silent_p.L118L|NSG1_ENST00000513555.1_Silent_p.L118L|NSG1_ENST00000397958.1_Silent_p.L118L																							GGTTCGTCCTCAAGGTAAAAC	0.597000													21	94					0	0	0.002299	0	0
KIAA1614	57710	broad.mit.edu	37	1	180905014	180905014	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:180905014C>T	ENST00000367588.4	+	5	2024	c.1969C>T	c.(1969-1971)Cac>Tac	p.H657Y	KIAA1614_ENST00000367587.1_Missense_Mutation_p.H278Y	NM_020950.1	NP_066001.1	Q5VZ46	K1614_HUMAN	KIAA1614	657										NS(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(12)|ovary(5)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(1)	33						GCCTCGAGGCCACAGGTGGTC	0.667000													47	10					0	0	0.002852	0	0
ADCY7	113	broad.mit.edu	37	16	50339721	50339721	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:50339721C>T	ENST00000394697.2	+	14	2053	c.1713C>T	c.(1711-1713)acC>acT	p.T571T	ADCY7_ENST00000254235.3_Silent_p.T571T|ADCY7_ENST00000537579.1_3'UTR|ADCY7_ENST00000538642.1_Silent_p.T571T|ADCY7_ENST00000566433.2_Silent_p.T571T			P51828	ADCY7_HUMAN	adenylate cyclase 7	571					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to ethanol|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of cAMP biosynthetic process|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			breast(1)|cervix(1)|endometrium(5)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)|skin(2)|stomach(1)|urinary_tract(3)	35		all_cancers(37;0.0127)		GBM - Glioblastoma multiforme(240;0.195)	Bromocriptine(DB01200)	ACTTCTACACCTTTGGGTCCA	0.667000													14	23					0	0	0.004990	0	0
KIAA1045	23349	broad.mit.edu	37	9	34972419	34972419	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:34972419G>A	ENST00000242315.3	+	3	537	c.455G>A	c.(454-456)aGg>aAg	p.R152K	KIAA1045_ENST00000544237.1_Missense_Mutation_p.R152K|KIAA1045_ENST00000476115.2_3'UTR	NM_015297.1	NP_056112.1	Q9UPV7	K1045_HUMAN	KIAA1045	152							calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(4)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			LUSC - Lung squamous cell carcinoma(32;0.00575)			GTCTGCACCAGGGTTTTCCAT	0.572000													39	60					0	0	0.002222	0	0
ABCB5	340273	broad.mit.edu	37	7	20784994	20784994	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:20784994C>T	ENST00000404938.2	+	26	4014	c.3362C>T	c.(3361-3363)cCa>cTa	p.P1121L	ABCB5_ENST00000258738.6_Missense_Mutation_p.P676L	NM_001163941.1	NP_001157413.1	Q2M3G0	ABCB5_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 5	676					regulation of membrane potential	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus	ATP binding|ATPase activity, coupled to transmembrane movement of substances|efflux transmembrane transporter activity			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(1)|pancreas(1)|prostate(1)|skin(10)|upper_aerodigestive_tract(1)	77						CGTGTGGTGCCATTAGATGAG	0.433000													28	57					0	0	0.001512	0	0
CRTAC1	55118	broad.mit.edu	37	10	99770962	99770962	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:99770962G>A	ENST00000370597.3	-	2	512	c.157C>T	c.(157-159)Cag>Tag	p.Q53*	CRTAC1_ENST00000370591.2_Nonsense_Mutation_p.Q53*|CRTAC1_ENST00000298819.4_Nonsense_Mutation_p.Q53*	NM_018058.6	NP_060528.3	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1	53						proteinaceous extracellular matrix	calcium ion binding			autonomic_ganglia(1)|breast(1)|endometrium(6)|kidney(3)|large_intestine(7)|lung(6)|ovary(6)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	35		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		TAGTTGAGCTGGGTGGGATTA	0.547000													32	47					0	0	0.002445	0	0
GATA2	2624	broad.mit.edu	37	3	128204626	128204626	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:128204626C>T	ENST00000341105.2	-	3	1146	c.815G>A	c.(814-816)gGg>gAg	p.G272E	GATA2_ENST00000430265.2_Missense_Mutation_p.G272E|GATA2_ENST00000487848.1_Missense_Mutation_p.G272E	NM_032638.4	NP_116027.2	P23769	GATA2_HUMAN	GATA binding protein 2	272					blood coagulation|negative regulation of fat cell differentiation|negative regulation of fat cell proliferation|negative regulation of neural precursor cell proliferation|negative regulation of Notch signaling pathway|phagocytosis|positive regulation of angiogenesis|positive regulation of phagocytosis|positive regulation of transcription from RNA polymerase II promoter	nucleoplasm	C2H2 zinc finger domain binding|chromatin binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(58)|kidney(2)|large_intestine(3)|lung(9)|prostate(3)|skin(1)|urinary_tract(1)	79				GBM - Glioblastoma multiforme(114;0.173)		GGCCGGTCCCCCCAGGAAGCC	0.642000			Mis		AML(CML blast transformation)								6	17					0	0	0.003080	0	0
MYO16	23026	broad.mit.edu	37	13	109707909	109707909	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:109707909C>T	ENST00000356711.2	+	27	3361	c.3235C>T	c.(3235-3237)Cct>Tct	p.P1079S	MYO16_ENST00000457511.2_Missense_Mutation_p.P591S|MYO16_ENST00000357550.2_Missense_Mutation_p.P1079S	NM_015011.1	NP_055826.1	Q9Y6X6	MYO16_HUMAN	myosin XVI	1079	Myosin head-like 2.				cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			NS(3)|breast(4)|central_nervous_system(2)|endometrium(10)|kidney(8)|large_intestine(27)|lung(51)|ovary(9)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	121	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			ATATGGATACCCTGTTCGCCT	0.433000													41	61					0	0	0.003610	0	0
USP11	8237	broad.mit.edu	37	X	47106768	47106768	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:47106768A>T	ENST00000377107.2	+	19	2840	c.2486A>T	c.(2485-2487)tAt>tTt	p.Y829F	USP11_ENST00000218348.3_Missense_Mutation_p.Y872F			P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	872					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|ovary(3)|pancreas(1)|stomach(1)	40						CTGTACAAATATGACCTCATC	0.572000													16	3					0	0	0.001216	0	0
IMPG2	50939	broad.mit.edu	37	3	100964675	100964675	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:100964675C>T	ENST00000193391.7	-	12	1701	c.1514G>A	c.(1513-1515)aGg>aAg	p.R505K		NM_016247.3	NP_057331.2	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	505					visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			NS(1)|breast(2)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(14)|lung(32)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						TCCAGAAGTCCTTTCCTCAGA	0.463000													38	105					0	0	0.003610	0	0
TTF1	7270	broad.mit.edu	37	9	135277532	135277532	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:135277532G>A	ENST00000334270.2	-	2	716	c.677C>T	c.(676-678)tCc>tTc	p.S226F		NM_001205296.1|NM_007344.3	NP_001192225.1|NP_031370.2	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase I	226					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	30		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		CCGGTTACTGGACTTTTTCTT	0.502000													30	7					0	0	0.001512	0	0
SHANK2	22941	broad.mit.edu	37	11	70333095	70333095	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:70333095G>A	ENST00000338508.4	-	32	3305	c.3306C>T	c.(3304-3306)gcC>gcT	p.A1102A	SHANK2_ENST00000449833.2_Silent_p.A506A|SHANK2_ENST00000423696.2_Silent_p.A722A|SHANK2_ENST00000409161.1_Silent_p.A505A			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	722					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TGGAGAGGAAGGCCGGGGAGT	0.692000													13	202					0	0	0.002450	0	0
WNT7B	7477	broad.mit.edu	37	22	46318890	46318890	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:46318890G>A	ENST00000339464.4	-	4	1270	c.896C>T	c.(895-897)cCc>cTc	p.P299L	WNT7B_ENST00000410089.1_Missense_Mutation_p.P283L|WNT7B_ENST00000409496.3_Missense_Mutation_p.P303L	NM_058238.2	NP_478679.1	P56706	WNT7B_HUMAN	wingless-type MMTV integration site family, member 7B	299					activation of JUN kinase activity|anterior/posterior pattern formation|axis specification|axonogenesis|canonical Wnt receptor signaling pathway|cell-cell signaling|cellular response to retinoic acid|central nervous system vasculogenesis|chorio-allantoic fusion|developmental growth involved in morphogenesis|embryonic placenta morphogenesis|establishment or maintenance of polarity of embryonic epithelium|fibroblast proliferation|forebrain regionalization|inner medullary collecting duct development|lens fiber cell development|lobar bronchus development|lung epithelium development|lung morphogenesis|lung-associated mesenchyme development|mammary gland epithelium development|metanephric collecting duct development|metanephric loop of Henle development|metanephros morphogenesis|negative regulation of smoothened signaling pathway|outer medullary collecting duct development|oxygen homeostasis|positive regulation of JNK cascade|positive regulation of osteoblast differentiation|renal inner medulla development|renal outer medulla development|stem cell proliferation|synapse organization|trachea cartilage morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled binding|signal transducer activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	19		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|LUAD - Lung adenocarcinoma(64;0.247)		GTCCGCGCCGGGCGACGTGCG	0.642000													22	10					0	0	0.002780	0	0
CES5A	221223	broad.mit.edu	37	16	55886881	55886881	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:55886881G>A	ENST00000521992.1	-	11	1417	c.1272C>T	c.(1270-1272)tcC>tcT	p.S424S	CES5A_ENST00000520435.1_Silent_p.S365S|CES5A_ENST00000518005.1_Silent_p.S289S|CES5A_ENST00000541580.1_5'UTR|CES5A_ENST00000319165.9_Silent_p.S395S|CES5A_ENST00000290567.9_Silent_p.S395S	NM_001190158.1	NP_001177087.1	Q6NT32	EST5A_HUMAN	carboxylesterase 5A	395						extracellular region	carboxylesterase activity|methyl indole-3-acetate esterase activity|methyl jasmonate esterase activity|methyl salicylate esterase activity			breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(8)|lung(13)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	39						TTTCAGTCAGGGAGTGCTTGT	0.473000													25	31					0	0	0.006320	0	0
KDR	3791	broad.mit.edu	37	4	55976878	55976878	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:55976878C>T	ENST00000263923.4	-	8	1329	c.1034G>A	c.(1033-1035)gGg>gAg	p.G345E		NM_002253.2	NP_002244.1	P35968	VGFR2_HUMAN	kinase insert domain receptor (a type III receptor tyrosine kinase)	345	Ig-like C2-type 4.				angiogenesis|cell differentiation|interspecies interaction between organisms|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of focal adhesion assembly|positive regulation of positive chemotaxis|regulation of cell shape	integral to plasma membrane	ATP binding|growth factor binding|Hsp90 protein binding|integrin binding|receptor signaling protein tyrosine kinase activity|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(6)|kidney(8)|large_intestine(16)|lung(71)|ovary(2)|prostate(2)|skin(10)|soft_tissue(4)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	135	all_cancers(7;0.0255)|all_lung(4;0.00175)|Lung NSC(11;0.00384)|all_epithelial(27;0.034)|Glioma(25;0.08)|all_neural(26;0.101)		Epithelial(7;0.189)		Sorafenib(DB00398)|Sunitinib(DB01268)	GACACGCTCCCCCACCGTGGC	0.413000			Mis		"""NSCLC, angiosarcoma"""					TSP Lung(20;0.16)			41	179					0	0	0.003610	0	0
DOK6	220164	broad.mit.edu	37	18	67406248	67406248	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:67406248G>A	ENST00000382713.5	+	6	837	c.647G>A	c.(646-648)gGa>gAa	p.G216E	DOK6_ENST00000584435.1_3'UTR	NM_152721.5	NP_689934.2	Q6PKX4	DOK6_HUMAN	docking protein 6	216	IRS-type PTB.						insulin receptor binding			central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(6)|lung(6)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	20		Colorectal(73;0.083)|Esophageal squamous(42;0.131)				ACAAGGGAAGGAGAAATGATC	0.443000													40	59					0	0	0.007835	0	0
CDH16	1014	broad.mit.edu	37	16	66948315	66948315	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:66948315C>T	ENST00000299752.4	-	7	777	c.583_splice	c.e7-1	p.G195_splice	CDH16_ENST00000394055.3_Splice_Site_p.G195_splice|CDH16_ENST00000565796.1_Splice_Site_p.G195_splice|CDH16_ENST00000568632.1_Intron|CDH16_ENST00000570262.1_Splice_Site_p.G115_splice	NM_001204744.1|NM_001204745.1|NM_004062.3	NP_001191673.1|NP_001191674.1|NP_004053.1	O75309	CAD16_HUMAN	cadherin 16, KSP-cadherin	195	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(1)|kidney(3)|large_intestine(10)|lung(15)|ovary(2)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GCTGGTGCTCCCTAGAACAGG	0.602000													12	25					0	0	0.001368	0	0
PIGR	5284	broad.mit.edu	37	1	207106416	207106416	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:207106416C>T	ENST00000356495.4	-	7	1984	c.1801G>A	c.(1801-1803)Gat>Aat	p.D601N		NM_002644.3	NP_002635.2	P01833	PIGR_HUMAN	polymeric immunoglobulin receptor	601						extracellular region|integral to plasma membrane	protein binding			central_nervous_system(2)|endometrium(5)|kidney(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						AGCCTGGGATCCTGAATGGCT	0.537000													26	75					0	0	0.004656	0	0
ASXL3	80816	broad.mit.edu	37	18	31325147	31325147	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:31325147C>T	ENST00000269197.5	+	12	5335	c.5335C>T	c.(5335-5337)Cca>Tca	p.P1779S		NM_030632.1	NP_085135.1	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3 (Drosophila)	1779					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			breast(3)|endometrium(3)|kidney(3)|large_intestine(6)|lung(22)|ovary(2)|pancreas(1)|skin(2)|urinary_tract(1)	43						CAACAGGCTTCCATTGCCTCT	0.498000													26	20					0	0	0.004656	0	0
DPCD	25911	broad.mit.edu	37	10	103348032	103348032	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:103348032G>A	ENST00000416979.2	+	4	877	c.449G>A	c.(448-450)gGa>gAa	p.G150E	DPCD_ENST00000470165.1_Intron			Q9BVM2	DPCD_HUMAN	deleted in primary ciliary dyskinesia homolog (mouse)	0							protein binding			endometrium(1)|large_intestine(1)|lung(2)|skin(1)	5						GAGTCAGCCGGAAGTGACCCT	0.627000													6	2					0	0	0.001168	0	0
HOXC8	3224	broad.mit.edu	37	12	54404894	54404894	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:54404894G>A	ENST00000040584.4	+	2	695	c.458G>A	c.(457-459)cGg>cAg	p.R153Q		NM_022658.3	NP_073149.1	P31273	HXC8_HUMAN	homeobox C8	153						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)|skin(3)	8						CGCAGTGGACGGCAAACTTAC	0.488000													16	46					0	0	0.004990	0	0
LSAMP	4045	broad.mit.edu	37	3	115571453	115571453	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:115571453C>T	ENST00000490035.1	-	4	1025	c.526G>A	c.(526-528)Gaa>Aaa	p.E176K	LSAMP_ENST00000498645.1_5'UTR|LSAMP_ENST00000539563.1_Missense_Mutation_p.E173K	NM_002338.3	NP_002329.2	Q13449	LSAMP_HUMAN	limbic system-associated membrane protein	176	Ig-like C2-type 2.				cell adhesion|nervous system development	anchored to membrane|plasma membrane				NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|kidney(1)|large_intestine(4)|lung(14)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	31		all_cancers(1;0.00189)|all_epithelial(1;0.0366)|Myeloproliferative disorder(1037;0.17)|all_neural(597;0.208)|Lung NSC(201;0.215)		GBM - Glioblastoma multiforme(114;0.00117)|LUSC - Lung squamous cell carcinoma(41;0.0407)|Lung(219;0.152)		TCTTCTCCTTCAAATTCCCTT	0.413000													30	41					0	0	0.001786	0	0
LILRB1	10859	broad.mit.edu	37	19	55144101	55144101	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55144101C>T	ENST00000396331.1	+	7	1205	c.848C>T	c.(847-849)aCc>aTc	p.T283I	LILRB1_ENST00000418536.2_Missense_Mutation_p.T283I|LILRB1_ENST00000396317.1_Missense_Mutation_p.T283I|LILRB1_ENST00000396321.2_Missense_Mutation_p.T283I|LILRB1_ENST00000434867.2_Missense_Mutation_p.T283I|LILRB1_ENST00000324602.7_Missense_Mutation_p.T283I|LILRB1_ENST00000427581.2_Missense_Mutation_p.T319I|LILRB1_ENST00000396332.4_Missense_Mutation_p.T283I|LILRB1_ENST00000448689.1_Missense_Mutation_p.T283I|LILRB1_ENST00000396315.1_Missense_Mutation_p.T283I|LILRB1_ENST00000396327.3_Missense_Mutation_p.T283I	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	283	Ig-like C2-type 3.				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		GCCAACTTCACCCTGGGCCCT	0.632000										HNSCC(37;0.09)			22	57					0	0	0.001882	0	0
ZNF286A	57335	broad.mit.edu	37	17	15619996	15619996	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:15619996C>T	ENST00000464847.2	+	5	1511	c.958C>T	c.(958-960)Cac>Tac	p.H320Y	ZNF286A_ENST00000593105.1_Missense_Mutation_p.H310Y|ZNF286A_ENST00000421016.1_Missense_Mutation_p.H320Y|ZNF286A_ENST00000585171.1_Intron|ZNF286A_ENST00000413242.2_Missense_Mutation_p.H320Y|ZNF286A_ENST00000395894.2_3'UTR|ZNF286A_ENST00000583566.1_Missense_Mutation_p.H320Y			Q9HBT8	Z286A_HUMAN	zinc finger protein 286A	320					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|pancreas(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	24				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.0781)		TCAGAGAATTCACGTTGGAGA	0.403000													12	23					0	0	0.002450	0	0
TNRC6B	23112	broad.mit.edu	37	22	40718959	40718959	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:40718959C>T	ENST00000454349.2	+	23	5427	c.5216C>T	c.(5215-5217)cCa>cTa	p.P1739L	TNRC6B_ENST00000301923.9_Missense_Mutation_p.P935L|TNRC6B_ENST00000402203.1_Missense_Mutation_p.P935L|TNRC6B_ENST00000335727.8_Missense_Mutation_p.P1629L	NM_001162501.1	NP_001155973.1	Q9UPQ9	TNR6B_HUMAN	trinucleotide repeat containing 6B	1739					gene silencing by RNA|regulation of translation	cytoplasmic mRNA processing body	nucleotide binding|RNA binding			breast(1)	1						GCAGCAACCCCAAGTGCGCCA	0.587000													4	9					0	0	0.000248	0	0
CYP4X1	260293	broad.mit.edu	37	1	47515123	47515123	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:47515123G>A	ENST00000371901.3	+	11	1552	c.1302G>A	c.(1300-1302)gaG>gaA	p.E434E	CYP4X1_ENST00000538609.1_Silent_p.E433E	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1	434						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						TCTCTCAGGAGAATTCTGATC	0.453000													26	88					0	0	0.006320	0	0
PIGO	84720	broad.mit.edu	37	9	35093436	35093436	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:35093436G>A	ENST00000378617.3	-	5	1315	c.921C>T	c.(919-921)ttC>ttT	p.F307F	PIGO_ENST00000341666.3_Silent_p.F307F|PIGO_ENST00000298004.5_Silent_p.F307F|PIGO_ENST00000361778.2_Silent_p.F307F	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	307					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			GGGTGCTGGGGAAGACTGCTG	0.537000													12	21					0	0	0.002450	0	0
IL7R	3575	broad.mit.edu	37	5	35876216	35876216	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:35876216G>A	ENST00000303115.3	+	8	1137	c.1008G>A	c.(1006-1008)gaG>gaA	p.E336E	IL7R_ENST00000343305.4_3'UTR	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	336					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			AAGAATCTGAGAAGCAGAGGC	0.488000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						14	41					0	0	0.004990	0	0
LILRB2	10288	broad.mit.edu	37	19	54778659	54778659	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54778659C>T	ENST00000391748.1	-	14	1799	c.1672G>A	c.(1672-1674)Gat>Aat	p.D558N	LILRB2_ENST00000314446.5_Missense_Mutation_p.D558N|LILRB2_ENST00000391746.1_3'UTR|LILRB2_ENST00000434421.1_Missense_Mutation_p.D443N|LILRB2_ENST00000391749.4_Missense_Mutation_p.D559N	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	559					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TAGGTCACATCCTGGGGGGCT	0.632000													21	51					0	0	0.003330	0	0
BPIFB2	80341	broad.mit.edu	37	20	31606475	31606475	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:31606475C>T	ENST00000170150.3	+	9	897	c.702C>T	c.(700-702)atC>atT	p.I234I		NM_025227.1	NP_079503.1	Q8N4F0	BPIL1_HUMAN	BPI fold containing family B, member 2	234						extracellular region	lipid binding										AGCCCATCATCCTGCCCACGG	0.632000													37	143					0	0	0.002222	0	0
RERE	473	broad.mit.edu	37	1	8568705	8568705	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:8568705C>T	ENST00000337907.3	-	9	1494	c.860G>A	c.(859-861)cGt>cAt	p.R287H	RERE_ENST00000400907.2_Missense_Mutation_p.R287H|RERE_ENST00000400908.2_Missense_Mutation_p.R287H|RERE_ENST00000377464.1_Missense_Mutation_p.R19H	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	287	ELM2.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		AGGACCGACACGAATCTCCCC	0.403000													14	57					0	0	0.003163	0	0
TNF	7124	broad.mit.edu	37	6	31545302	31545302	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31545302C>T	ENST00000449264.2	+	4	865	c.690C>T	c.(688-690)atC>atT	p.I230I		NM_000594.3	NP_000585.2	P01375	TNFA_HUMAN	tumor necrosis factor	230					activation of caspase activity|activation of MAPK activity|activation of MAPKKK activity|anti-apoptosis|cellular response to nicotine|chronic inflammatory response to antigenic stimulus|embryonic digestive tract development|induction of apoptosis via death domain receptors|induction of necroptosis by extracellular signals|leukocyte tethering or rolling|necrotic cell death|negative regulation of branching involved in lung morphogenesis|negative regulation of cytokine secretion involved in immune response|negative regulation of fat cell differentiation|negative regulation of interleukin-6 production|negative regulation of lipid catabolic process|negative regulation of lipid storage|negative regulation of viral genome replication|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of chemokine biosynthetic process|positive regulation of chemokine production|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of fever generation|positive regulation of heterotypic cell-cell adhesion|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of membrane protein ectodomain proteolysis|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of NFAT protein import into nucleus|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of podosome assembly|positive regulation of protein complex disassembly|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|receptor biosynthetic process|regulation of insulin secretion|response to glucocorticoid stimulus|response to salt stress|response to virus|sequestering of triglyceride|transformed cell apoptosis|tumor necrosis factor-mediated signaling pathway	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane raft|phagocytic cup|recycling endosome	cytokine activity|identical protein binding|protease binding|transcription regulatory region DNA binding|tumor necrosis factor receptor binding			large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|skin(3)	8		Ovarian(999;0.00556)			Adalimumab(DB00051)|Adenosine(DB00640)|Amrinone(DB01427)|Atorvastatin(DB01076)|Chloroquine(DB00608)|Clenbuterol(DB01407)|Etanercept(DB00005)|Glucosamine(DB01296)|Infliximab(DB00065)|Naltrexone(DB00704)|Pranlukast(DB01411)|Procaterol(DB01366)|Saquinavir(DB01232)|Simvastatin(DB00641)|Thalidomide(DB01041)	ACTTTGGGATCATTGCCCTGT	0.572000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				15	135					0	0	0.004990	0	0
CCDC149	91050	broad.mit.edu	37	4	24833217	24833217	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:24833217G>A	ENST00000504487.1	-	9	882	c.876C>T	c.(874-876)tcC>tcT	p.S292S	CCDC149_ENST00000389609.4_Silent_p.S292S|CCDC149_ENST00000502801.1_Intron|CCDC149_ENST00000428116.2_Intron	NM_001130726.2	NP_001124198.1	B4DZG3	B4DZG3_HUMAN	coiled-coil domain containing 149	292										cervix(1)|endometrium(1)|large_intestine(2)|lung(3)	7		Breast(46;0.173)				GGTCAGAAATGGACTGCGGAG	0.463000													15	67					0	0	0.004007	0	0
HCAR2	338442	broad.mit.edu	37	12	123186926	123186926	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:123186926G>A	ENST00000328880.5	-	1	964	c.905C>T	c.(904-906)cCc>cTc	p.P302L	HCAR1_ENST00000356987.2_Intron|RP11-324E6.6_ENST00000543611.1_lincRNA	NM_177551.3	NP_808219.1	Q8TDS4	HCAR2_HUMAN	hydroxycarboxylic acid receptor 2	302					negative regulation of lipid catabolic process|neutrophil apoptosis|positive regulation of adiponectin secretion|positive regulation of neutrophil apoptosis	integral to membrane|plasma membrane	nicotinic acid receptor activity|purinergic nucleotide receptor activity, G-protein coupled			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(5)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	15					Mepenzolate(DB04843)|Niacin(DB00627)	GAAGAAGTTGGGAAAGGATGG	0.552000													12	75					0	0	0.004007	0	0
TMEM8B	51754	broad.mit.edu	37	9	35847037	35847037	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:35847037G>A	ENST00000377996.1	+	9	2279	c.864G>A	c.(862-864)tgG>tgA	p.W288*	TMEM8B_ENST00000377988.2_Intron|TMEM8B_ENST00000377991.4_Intron|TMEM8B_ENST00000439587.2_Nonsense_Mutation_p.W288*			A6NDV4	TMM8B_HUMAN	transmembrane protein 8B	359					cell-matrix adhesion|regulation of growth|regulation of mitotic cell cycle	cell surface|endoplasmic reticulum|integral to membrane|mitochondrion|nucleus|plasma membrane	protein binding			breast(1)|endometrium(2)|large_intestine(2)|lung(1)|ovary(1)	7						CTTGTGCATGGTGGTGGGTCA	0.522000													34	68					0	0	0.007835	0	0
AC096579.13	0	broad.mit.edu	37	2	89160296	89160296	+	RNA	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:89160296G>A	ENST00000452230.1	-	0	39				AC096579.7_ENST00000430694.1_RNA																							CTTTTTGAAAGAATCTGGTAC	0.358000													7	15					0	0	0.001984	0	0
NDUFB2	4708	broad.mit.edu	37	7	140404669	140404669	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:140404669C>T	ENST00000476279.1	+	3	327	c.253C>T	c.(253-255)Ccg>Tcg	p.P85S	NDUFB2_ENST00000247866.4_Missense_Mutation_p.P85S|NDUFB2_ENST00000482954.1_Missense_Mutation_p.P21S|NDUFB2_ENST00000471136.1_Missense_Mutation_p.P73S|NDUFB2_ENST00000464564.2_3'UTR|NDUFB2_ENST00000204307.5_Missense_Mutation_p.P75S|NDUFB2_ENST00000465506.1_Missense_Mutation_p.P85S|NDUFB2_ENST00000472695.1_Missense_Mutation_p.P21S|NDUFB2_ENST00000461457.1_Intron|NDUFB2_ENST00000476470.1_Missense_Mutation_p.P21S|NDUFB2_ENST00000460088.1_Missense_Mutation_p.P21S|NDUFB2_ENST00000475276.1_Missense_Mutation_p.P58S			O95178	NDUB2_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa	85					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|stomach(1)	10	Melanoma(164;0.00956)				NADH(DB00157)	GGGTCACTTTCCGTATCCTGA	0.378000													29	35					0	0	0.001786	0	0
TET1	80312	broad.mit.edu	37	10	70441247	70441247	+	Splice_Site	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:70441247T>G	ENST00000373644.4	+	9	5123		c.e9+2			NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1						DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						CAAAATCAGGTATGTATTGGT	0.368000													6	15					0	0	0.001168	0	0
OR3A2	4995	broad.mit.edu	37	17	3181450	3181450	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:3181450G>A	ENST00000408891.2	-	1	818	c.780C>T	c.(778-780)ttC>ttT	p.F260F		NM_002551.3	NP_002542.3	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A, member 2	260					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						CTCTTCCAAAGAAAAGACAAA	0.507000													17	32					0	0	0.007413	0	0
COL4A2	1284	broad.mit.edu	37	13	111111269	111111269	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:111111269C>T	ENST00000360467.5	+	22	1890	c.1584C>T	c.(1582-1584)ttC>ttT	p.F528F	COL4A2-AS2_ENST00000458403.2_RNA	NM_001846.2	NP_001837.2	P08572	CO4A2_HUMAN	collagen, type IV, alpha 2	528	Triple-helical region.				angiogenesis|axon guidance|extracellular matrix organization|negative regulation of angiogenesis	collagen type IV	extracellular matrix structural constituent|protein binding			NS(1)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|liver(2)|lung(48)|ovary(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	80	all_cancers(4;2.21e-12)|all_epithelial(4;2.63e-07)|all_lung(23;5.81e-06)|Lung NSC(43;0.000274)|Colorectal(4;0.00323)|all_neural(89;0.0565)|Lung SC(71;0.0753)|Medulloblastoma(90;0.0922)	Breast(118;0.212)	BRCA - Breast invasive adenocarcinoma(86;0.11)|all cancers(43;0.151)			TCCCTGGGTTCCCAGGGCTCA	0.597000													4	2					0	0	0.000248	0	0
RBMXL2	27288	broad.mit.edu	37	11	7111152	7111152	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:7111152C>T	ENST00000306904.5	+	1	988	c.801C>T	c.(799-801)gaC>gaT	p.D267D		NM_014469.4	NP_055284.3	O75526	HNRGT_HUMAN	RNA binding motif protein, X-linked-like 2	267	Arg/Gly/Pro-rich.					nucleus|ribonucleoprotein complex	nucleotide binding|RNA binding	p.D267D(1)		NS(1)|breast(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	15				Epithelial(150;5.14e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		GAGGTCGCGACCGTGACTACG	0.667000													7	14					0	0	0.003080	0	0
LMO7	4008	broad.mit.edu	37	13	76415295	76415295	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:76415295C>T	ENST00000357063.3	+	24	5049	c.3789C>T	c.(3787-3789)gcC>gcT	p.A1263A	LMO7_ENST00000377534.3_Silent_p.A1263A|LMO7_ENST00000341547.4_Silent_p.A929A|LMO7_ENST00000465261.2_Silent_p.A978A|LMO7_ENST00000321797.8_Silent_p.A978A|LMO7_ENST00000526202.1_Silent_p.A855A			Q8WWI1	LMO7_HUMAN	LIM domain 7	1263						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(2)|large_intestine(20)|lung(15)|ovary(2)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	56		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		GGCAAAGGGCCAAACAGGAGG	0.378000													18	32					0	0	0.002299	0	0
KIAA1211	57482	broad.mit.edu	37	4	57182492	57182492	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:57182492C>T	ENST00000504228.1	+	6	2929	c.2824C>T	c.(2824-2826)Cag>Tag	p.Q942*	KIAA1211_ENST00000541073.1_Nonsense_Mutation_p.Q935*|KIAA1211_ENST00000264229.6_Nonsense_Mutation_p.Q942*			Q6ZU35	K1211_HUMAN	KIAA1211	942	Pro-rich.									endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					GGCCAGCAGCCAGACCCCGGC	0.652000													6	32					0	0	0.001168	0	0
AGBL1	123624	broad.mit.edu	37	15	86807597	86807597	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:86807597G>A	ENST00000441037.2	+	10	1152	c.1057G>A	c.(1057-1059)Gac>Aac	p.D353N	AGBL1_ENST00000421325.2_Missense_Mutation_p.D353N|AGBL1_ENST00000389298.3_Missense_Mutation_p.D84N	NM_152336.2	NP_689549.2	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	353					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding			NS(3)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(2)|lung(28)|ovary(2)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	62						CTACAGCAAGGACCAAAGCTC	0.493000													5	7					0	0	0.001168	0	0
TREML1	340205	broad.mit.edu	37	6	41121742	41121742	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:41121742C>T	ENST00000373127.4	-	2	178	c.130G>A	c.(130-132)Gat>Aat	p.D44N	TREML1_ENST00000437044.2_Intron|TREML1_ENST00000426005.2_Missense_Mutation_p.D44N	NM_001271807.1	NP_001258736.1	Q86YW5	TRML1_HUMAN	triggering receptor expressed on myeloid cells-like 1	44	Ig-like V-type.				calcium-mediated signaling|innate immune response|platelet activation	cell surface|integral to membrane|plasma membrane|platelet alpha granule	protein binding|receptor activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)	13	Ovarian(28;0.0418)|Colorectal(47;0.196)					GCTTTGACATCCTGGAGCCTG	0.632000													11	73					0	0	0.000673	0	0
NEBL	10529	broad.mit.edu	37	10	21106570	21106570	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:21106570C>T	ENST00000377122.4	-	21	2503	c.2107G>A	c.(2107-2109)Gag>Aag	p.E703K	NEBL_ENST00000377159.4_Intron|NEBL_ENST00000417816.2_Intron	NM_006393.2	NP_006384.1	O76041	NEBL_HUMAN	nebulette	703					regulation of actin filament length		actin binding|structural constituent of muscle			NS(2)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|lung(22)|ovary(2)|pancreas(1)|prostate(2)|skin(8)|stomach(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	70						CTCTTCAGCTCTGGTGGATCA	0.378000													20	47					0	0	0.003330	0	0
BAI2	576	broad.mit.edu	37	1	32204489	32204489	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:32204489G>A	ENST00000373658.3	-	16	2886	c.2545C>T	c.(2545-2547)Cct>Tct	p.P849S	BAI2_ENST00000398547.1_Missense_Mutation_p.P782S|BAI2_ENST00000527361.1_Missense_Mutation_p.P849S|BAI2_ENST00000398542.1_Missense_Mutation_p.P782S|BAI2_ENST00000373655.2_Missense_Mutation_p.P849S|BAI2_ENST00000257070.4_Missense_Mutation_p.P849S|BAI2_ENST00000398556.3_Missense_Mutation_p.P797S|BAI2_ENST00000440175.2_Missense_Mutation_p.P491S|BAI2_ENST00000398538.1_Missense_Mutation_p.P837S	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	849					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		GGCTGGGTAGGGGGGCGCACA	0.632000													22	112					0	0	0.006320	0	0
C5orf34	375444	broad.mit.edu	37	5	43502496	43502496	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:43502496G>A	ENST00000306862.2	-	6	1505	c.1130C>T	c.(1129-1131)tCt>tTt	p.S377F	RP11-159F24.3_ENST00000505645.1_RNA	NM_198566.2	NP_940968.1	Q96MH7	CE034_HUMAN	chromosome 5 open reading frame 34	377										breast(2)|endometrium(2)|large_intestine(2)|lung(11)|ovary(1)|prostate(1)|stomach(2)	21	Lung NSC(6;2.07e-05)					TTCTTGAATAGAATAATAAGT	0.328000													35	82					0	0	0.004289	0	0
PHLPP2	23035	broad.mit.edu	37	16	71736601	71736601	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:71736601G>A	ENST00000393524.2	-	2	1051	c.318C>T	c.(316-318)atC>atT	p.I106I	PHLPP2_ENST00000568954.1_Silent_p.I106I|PHLPP2_ENST00000356272.3_Silent_p.I106I|PHLPP2_ENST00000567016.1_Silent_p.I141I|PHLPP2_ENST00000360429.3_Silent_p.I106I			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	106						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						AATCATAAACGATCTGAAGAG	0.363000													20	46					0	0	0.003330	0	0
PEX1	5189	broad.mit.edu	37	7	92138668	92138668	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:92138668G>A	ENST00000248633.4	-	9	1740	c.1645C>T	c.(1645-1647)Cct>Tct	p.P549S	PEX1_ENST00000428214.1_Missense_Mutation_p.P549S|PEX1_ENST00000541751.1_Intron|PEX1_ENST00000438045.1_Missense_Mutation_p.P227S	NM_000466.2	NP_000457.1	O43933	PEX1_HUMAN	peroxisomal biogenesis factor 1	549					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TTTAAAAAAGGAAGAATAAAG	0.333000													14	20					0	0	0.001855	0	0
PGK2	5232	broad.mit.edu	37	6	49754364	49754364	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:49754364C>T	ENST00000304801.3	-	1	689	c.537G>A	c.(535-537)gtG>gtA	p.V179V		NM_138733.4	NP_620061.2	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	179					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			autonomic_ganglia(1)|endometrium(3)|large_intestine(12)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	47	Lung NSC(77;0.0402)					GGGGCAGATTCACTCCCACCA	0.468000													20	78					0	0	0.001882	0	0
RYR1	6261	broad.mit.edu	37	19	38931463	38931463	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:38931463G>A	ENST00000355481.4	+	2	255	c.124G>A	c.(124-126)Ggc>Agc	p.G42S	RYR1_ENST00000359596.3_Missense_Mutation_p.G42S|RYR1_ENST00000360985.3_Missense_Mutation_p.G42S	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	42					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CGAGGGCTTCGGCAACCGCCT	0.662000													7	13					0	0	0.001984	0	0
ILDR1	286676	broad.mit.edu	37	3	121720677	121720677	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:121720677C>T	ENST00000273691.3	-	4	519	c.414G>A	c.(412-414)tgG>tgA	p.W138*	ILDR1_ENST00000460554.1_5'UTR|ILDR1_ENST00000393631.1_Intron|ILDR1_ENST00000344209.5_Nonsense_Mutation_p.W138*|ILDR1_ENST00000462014.1_Nonsense_Mutation_p.W150*	NM_175924.3	NP_787120.1	Q86SU0	ILDR1_HUMAN	immunoglobulin-like domain containing receptor 1	138	Ig-like V-type.					cytosol|integral to membrane|plasma membrane	receptor activity			central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	25				GBM - Glioblastoma multiforme(114;0.156)		CTCCATGGTCCCACCACATCA	0.498000													26	39					0	0	0.003330	0	0
TOX	9760	broad.mit.edu	37	8	59720342	59720342	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:59720342C>T	ENST00000361421.1	-	9	1765	c.1544_splice	c.e9-1	p.G515_splice		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	515						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				TCTGCATGCCCCTGTAGGAAG	0.448000											OREG0018787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	82					0	0	0.003163	0	0
LMTK3	114783	broad.mit.edu	37	19	49000689	49000689	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:49000689C>T	ENST00000600059.1	-	11	3864	c.3637G>A	c.(3637-3639)Gac>Aac	p.D1213N	LMTK3_ENST00000270238.3_Missense_Mutation_p.D1242N					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GGTCCCAAGTCCAAGAATAGT	0.682000													13	36					0	0	0.002450	0	0
CIB4	130106	broad.mit.edu	37	2	26806696	26806696	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:26806696A>C	ENST00000288861.4	-	5	452	c.399T>G	c.(397-399)gaT>gaG	p.D133E	CIB4_ENST00000405346.3_5'UTR	NM_001029881.1	NP_001025052.1	A0PJX0	CIB4_HUMAN	calcium and integrin binding family member 4	133							calcium ion binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)|ovary(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CAGACATGTCATCACTGTTCA	0.557000													18	66					0	0	0.007413	0	0
ASH1L	55870	broad.mit.edu	37	1	155450034	155450034	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:155450034G>A	ENST00000368346.3	-	3	3266	c.2627C>T	c.(2626-2628)tCc>tTc	p.S876F	ASH1L_ENST00000392403.3_Missense_Mutation_p.S876F			Q9NR48	ASH1L_HUMAN	ash1 (absent, small, or homeotic)-like (Drosophila)	876					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(13)|large_intestine(28)|lung(39)|ovary(2)|pancreas(1)|prostate(6)|skin(11)|upper_aerodigestive_tract(2)|urinary_tract(4)	124	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			TTGTTTGAAGGAAGGGATTTC	0.418000													141	54					0	0	0.003610	0	0
TNF	7124	broad.mit.edu	37	6	31543539	31543539	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31543539C>T	ENST00000449264.2	+	1	196	c.21C>T	c.(19-21)atC>atT	p.I7I		NM_000594.3	NP_000585.2	P01375	TNFA_HUMAN	tumor necrosis factor	7					activation of caspase activity|activation of MAPK activity|activation of MAPKKK activity|anti-apoptosis|cellular response to nicotine|chronic inflammatory response to antigenic stimulus|embryonic digestive tract development|induction of apoptosis via death domain receptors|induction of necroptosis by extracellular signals|leukocyte tethering or rolling|necrotic cell death|negative regulation of branching involved in lung morphogenesis|negative regulation of cytokine secretion involved in immune response|negative regulation of fat cell differentiation|negative regulation of interleukin-6 production|negative regulation of lipid catabolic process|negative regulation of lipid storage|negative regulation of viral genome replication|positive regulation of calcidiol 1-monooxygenase activity|positive regulation of chemokine biosynthetic process|positive regulation of chemokine production|positive regulation of cytokine secretion|positive regulation of ERK1 and ERK2 cascade|positive regulation of fever generation|positive regulation of heterotypic cell-cell adhesion|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of membrane protein ectodomain proteolysis|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of NFAT protein import into nucleus|positive regulation of nitric oxide biosynthetic process|positive regulation of osteoclast differentiation|positive regulation of peptidyl-serine phosphorylation|positive regulation of podosome assembly|positive regulation of protein complex disassembly|positive regulation of smooth muscle cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of vitamin D biosynthetic process|protein import into nucleus, translocation|receptor biosynthetic process|regulation of insulin secretion|response to glucocorticoid stimulus|response to salt stress|response to virus|sequestering of triglyceride|transformed cell apoptosis|tumor necrosis factor-mediated signaling pathway	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane raft|phagocytic cup|recycling endosome	cytokine activity|identical protein binding|protease binding|transcription regulatory region DNA binding|tumor necrosis factor receptor binding			large_intestine(1)|lung(2)|ovary(1)|pancreas(1)|skin(3)	8		Ovarian(999;0.00556)			Adalimumab(DB00051)|Adenosine(DB00640)|Amrinone(DB01427)|Atorvastatin(DB01076)|Chloroquine(DB00608)|Clenbuterol(DB01407)|Etanercept(DB00005)|Glucosamine(DB01296)|Infliximab(DB00065)|Naltrexone(DB00704)|Pranlukast(DB01411)|Procaterol(DB01366)|Saquinavir(DB01232)|Simvastatin(DB00641)|Thalidomide(DB01041)	AAAGCATGATCCGGGACGTGG	0.622000									Naso-/Oropharyngeal/Laryngeal Cancer, Familial Clustering of				24	324					0	0	0.004656	0	0
FCRL3	115352	broad.mit.edu	37	1	157665914	157665914	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:157665914C>T	ENST00000368184.3	-	7	1339	c.1048G>A	c.(1048-1050)Gag>Aag	p.E350K	FCRL3_ENST00000368186.5_Missense_Mutation_p.E350K|RP11-367J7.3_ENST00000453692.1_RNA|FCRL3_ENST00000473231.1_5'UTR	NM_052939.3	NP_443171.2	Q96P31	FCRL3_HUMAN	Fc receptor-like 3	350	Ig-like C2-type 4.					integral to membrane|plasma membrane	receptor activity			autonomic_ganglia(1)|breast(3)|endometrium(7)|kidney(1)|large_intestine(13)|lung(31)|ovary(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)	69	all_hematologic(112;0.0378)					GCATCACTCTCCTTCACGGTG	0.517000													63	25					0	0	0.003610	0	0
BRINP1	1620	broad.mit.edu	37	9	121929406	121929406	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:121929406C>T	ENST00000265922.3	-	8	2703	c.2242G>A	c.(2242-2244)Gag>Aag	p.E748K	DBC1_ENST00000482797.1_Intron	NM_014618.2	NP_055433.2	O60477	DBC1_HUMAN		748					cell cycle arrest|cell death	cytoplasm	protein binding			NS(1)|breast(3)|central_nervous_system(3)|endometrium(8)|kidney(2)|large_intestine(15)|liver(1)|lung(34)|ovary(3)|prostate(3)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	83						TTGAGGATCTCCGTGTTGTAC	0.512000													62	93					0	0	0.003610	0	0
ZAN	7455	broad.mit.edu	37	7	100348286	100348286	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:100348286C>T	ENST00000542585.1	+	0	1436				ZAN_ENST00000421100.1_RNA|ZAN_ENST00000546292.1_RNA|ZAN_ENST00000349350.6_RNA|ZAN_ENST00000443370.1_RNA|ZAN_ENST00000427578.1_RNA|ZAN_ENST00000546213.1_RNA|ZAN_ENST00000449052.1_RNA|ZAN_ENST00000348028.3_RNA|ZAN_ENST00000538115.1_RNA	NM_003386.1	NP_003377.1	Q9Y493	ZAN_HUMAN	zonadhesin (gene/pseudogene)						binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				NS(2)|breast(3)|central_nervous_system(3)|endometrium(21)|kidney(6)|large_intestine(18)|lung(60)|ovary(4)|pancreas(3)|prostate(5)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)	139	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CGAGTTCTCCCAGGCAGGCCA	0.577000													6	14					0	0	0.001168	0	0
EPHA10	284656	broad.mit.edu	37	1	38184057	38184057	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:38184057C>T	ENST00000373048.4	-	17	3013	c.3014G>A	c.(3013-3015)gGg>gAg	p.G1005E	EPHA10_ENST00000540011.1_3'UTR|EPHA10_ENST00000446149.2_5'UTR|EPHA10_ENST00000330210.7_Missense_Mutation_p.G500E|EPHA10_ENST00000427468.2_Missense_Mutation_p.G1005E	NM_001099439.1	NP_001092909.1	Q5JZY3	EPHAA_HUMAN	EPH receptor A10	1005						extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			NS(2)|breast(4)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(4)|lung(13)|prostate(3)|skin(8)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				CACCTGCACCCCCTGGCCCTG	0.662000													18	72					0	0	0.001216	0	0
NLRP1	22861	broad.mit.edu	37	17	5421208	5421208	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:5421208C>T	ENST00000345221.3	-	14	4338		c.e14-1		NLRP1_ENST00000577119.1_Splice_Site|NLRP1_ENST00000572272.1_Splice_Site|NLRP1_ENST00000262467.5_Splice_Site|NLRP1_ENST00000269280.4_Splice_Site|NLRP1_ENST00000354411.3_Splice_Site	NM_014922.4|NM_033004.3|NM_033007.3	NP_055737.1|NP_127497.1|NP_127500.1	Q9C000	NALP1_HUMAN	NLR family, pyrin domain containing 1						defense response to bacterium|induction of apoptosis|neuron apoptosis|positive regulation of interleukin-1 beta secretion|response to muramyl dipeptide	cytoplasm|NALP1 inflammasome complex|nucleus	ATP binding|caspase activator activity|enzyme binding|protein domain specific binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(17)|liver(5)|lung(17)|ovary(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		Colorectal(1115;3.48e-05)				GCTCCAGTTCCTGAAGAGGCA	0.532000													14	24					0	0	0.003163	0	0
GMEB1	10691	broad.mit.edu	37	1	29041250	29041250	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:29041250G>A	ENST00000373816.1	+	10	1795	c.1657G>A	c.(1657-1659)Gtt>Att	p.V553I	GMEB1_ENST00000361872.4_Missense_Mutation_p.V553I|GMEB1_ENST00000294409.2_Missense_Mutation_p.V563I|GMEB1_ENST00000480454.1_3'UTR	NM_024482.2	NP_077808.1	Q9Y692	GMEB1_HUMAN	glucocorticoid modulatory element binding protein 1	563					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|metal ion binding|transcription coactivator activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(4)	11		Colorectal(325;3.46e-05)|Lung NSC(340;0.000451)|all_lung(284;0.00063)|Breast(348;0.00502)|Renal(390;0.00555)|all_neural(195;0.0227)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0563)|Medulloblastoma(700;0.123)		Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0221)|KIRC - Kidney renal clear cell carcinoma(1967;0.0296)|READ - Rectum adenocarcinoma(331;0.0649)		CCAGCATCAAGTTCACAATGT	0.423000													25	42					0	0	0.005443	0	0
UTRN	7402	broad.mit.edu	37	6	144852338	144852338	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:144852338G>A	ENST00000367545.3	+	41	6057	c.6057_splice	c.e41+1	p.Q2019_splice		NM_007124.2	NP_009055.2	P46939	UTRO_HUMAN	utrophin	2019					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|cervix(2)|endometrium(21)|kidney(10)|large_intestine(29)|lung(56)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	148		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TACATCAGCAGGTGAGTGCTT	0.443000													10	11					0	0	0.001855	0	0
NCR2	9436	broad.mit.edu	37	6	41318576	41318576	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:41318576G>A	ENST00000373089.5	+	5	893	c.805G>A	c.(805-807)Gat>Aat	p.D269N	NCR2_ENST00000373083.4_3'UTR|NCR2_ENST00000373086.3_3'UTR	NM_004828.3	NP_004819.2	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	269	Poly-Asp.				cellular defense response	integral to plasma membrane	transmembrane receptor activity			NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(1)	14	Ovarian(28;0.0327)|Colorectal(47;0.196)					taagataagcgatgatgatga	0.403000													7	78					0	0	0.001984	0	0
SCN11A	11280	broad.mit.edu	37	3	38889067	38889067	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:38889067G>A	ENST00000302328.3	-	26	4692	c.4494C>T	c.(4492-4494)ttC>ttT	p.F1498F	SCN11A_ENST00000450244.1_Silent_p.F1498F|SCN11A_ENST00000456224.3_Silent_p.F1460F	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	1498					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	GACCAATGTTGAACAGAGAAG	0.468000													18	42					0	0	0.006122	0	0
EFCAB5	374786	broad.mit.edu	37	17	28380942	28380942	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:28380942G>A	ENST00000394835.3	+	10	2162	c.1970G>A	c.(1969-1971)gGa>gAa	p.G657E	EFCAB5_ENST00000320856.5_Missense_Mutation_p.G657E|EFCAB5_ENST00000541045.1_Missense_Mutation_p.G314E|EFCAB5_ENST00000536908.2_Missense_Mutation_p.G601E|EFCAB5_ENST00000378738.3_Missense_Mutation_p.G657E|EFCAB5_ENST00000394832.2_Missense_Mutation_p.G657E	NM_198529.3	NP_940931.2	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5	657							calcium ion binding			breast(7)|endometrium(2)|kidney(4)|large_intestine(11)|lung(14)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	43						GGACCTTATGGAGAGATAATT	0.388000													43	24					0	0	0.002222	0	0
ABRA	137735	broad.mit.edu	37	8	107781950	107781950	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:107781950G>A	ENST00000311955.3	-	1	523	c.469C>T	c.(469-471)Cca>Tca	p.P157S		NM_139166.4	NP_631905.1	Q8N0Z2	ABRA_HUMAN	actin-binding Rho activating protein	157					positive regulation of Rho protein signal transduction|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent|transmembrane transport	actin cytoskeleton|plasma membrane|sarcomere	actin binding			breast(1)|kidney(4)|large_intestine(7)|lung(11)|ovary(2)|prostate(2)	27			OV - Ovarian serous cystadenocarcinoma(57;3.83e-09)			CTCCGCGTTGGGGAGCCGTGG	0.582000													24	164					0	0	0.004656	0	0
OR2A5	393046	broad.mit.edu	37	7	143748222	143748222	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:143748222C>T	ENST00000408906.2	+	1	762	c.728C>T	c.(727-729)tCc>tTc	p.S243F		NM_012365.1	NP_036497.1	Q96R48	OR2A5_HUMAN	olfactory receptor, family 2, subfamily A, member 5	243					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			cervix(1)|endometrium(3)|large_intestine(5)|lung(23)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	38	Melanoma(164;0.0783)					ACCTGCTCCTCCCACCTTTGC	0.622000													32	46					0	0	0.001512	0	0
RAC1	5879	broad.mit.edu	37	7	6439791	6439791	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:6439791C>T	ENST00000348035.4	+	4	473	c.260C>T	c.(259-261)cCt>cTt	p.P87L	RAC1_ENST00000488373.1_3'UTR|RAC1_ENST00000356142.4_Missense_Mutation_p.P106L	NM_006908.4	NP_008839.2	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	87					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			cervix(1)|endometrium(1)|lung(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	8		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	CTTGTGAGTCCTGCATCATTT	0.343000													27	462					0	0	0.001512	0	0
RPRD2	23248	broad.mit.edu	37	1	150445429	150445429	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:150445429C>T	ENST00000401000.4	+	10	3992	c.3927C>T	c.(3925-3927)acC>acT	p.T1309T	RPRD2_ENST00000369068.4_Silent_p.T1335T|RPRD2_ENST00000492220.1_3'UTR			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	1335	Pro-rich.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						TTCAAGGGACCCTGGCTGAGC	0.637000													18	8					0	0	0.001216	0	0
ARHGAP22	58504	broad.mit.edu	37	10	49687791	49687791	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:49687791C>T	ENST00000249601.4	-	4	635	c.339G>A	c.(337-339)cgG>cgA	p.R113R	ARHGAP22_ENST00000417912.2_Silent_p.R113R|ARHGAP22_ENST00000374172.1_5'UTR|ARHGAP22_ENST00000417247.2_Silent_p.R23R|ARHGAP22_ENST00000435790.2_Silent_p.R119R|ARHGAP22_ENST00000374170.1_Silent_p.R23R	NM_001256024.1|NM_021226.3	NP_001242953.1|NP_067049.2	Q7Z5H3	RHG22_HUMAN	Rho GTPase activating protein 22	113	PH.				angiogenesis|cell differentiation|regulation of small GTPase mediated signal transduction|regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol|nucleus	GTPase activator activity			endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GCACCTTCTCCCGCTCCCCGG	0.677000													4	4					0	0	0.000248	0	0
GPR110	266977	broad.mit.edu	37	6	46996787	46996787	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:46996787C>T	ENST00000371253.2	-	2	226	c.11G>A	c.(10-12)gGa>gAa	p.G4E	GPR110_ENST00000449332.2_5'UTR|GPR110_ENST00000371243.2_Missense_Mutation_p.G4E	NM_153840.2	NP_722582.2	Q5T601	GP110_HUMAN	G protein-coupled receptor 110	4					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(2)|lung(6)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	29						CCACAGCACTCCAACTTTCAT	0.483000													17	58					0	0	0.006122	0	0
IDI2	91734	broad.mit.edu	37	10	1070537	1070537	+	Missense_Mutation	SNP	C	C	T	rs61738901		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:1070537C>T	ENST00000277517.1	-	2	191	c.127G>A	c.(127-129)Gaa>Aaa	p.E43K	IDI2-AS1_ENST00000437374.1_RNA|IDI2-AS1_ENST00000434470.1_RNA|IDI2-AS1_ENST00000428780.2_RNA|IDI2-AS1_ENST00000536039.1_RNA|IDI2-AS1_ENST00000420381.1_RNA	NM_033261.2	NP_150286.1	Q9BXS1	IDI2_HUMAN	isopentenyl-diphosphate delta isomerase 2	43					carotenoid biosynthetic process|cholesterol biosynthetic process	cytosol|peroxisome	hydrolase activity|isopentenyl-diphosphate delta-isomerase activity|metal ion binding			kidney(1)|large_intestine(3)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	9		Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.143)	Epithelial(11;0.067)|OV - Ovarian serous cystadenocarcinoma(14;0.169)|all cancers(11;0.192)		TCAATGTTTTCGTTCAGATGG	0.498000													15	14					0	0	0.003163	0	0
MYO15A	51168	broad.mit.edu	37	17	18022156	18022156	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:18022156G>A	ENST00000205890.5	+	2	380	c.42G>A	c.(40-42)ggG>ggA	p.G14G		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	14	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					ccaagaaagggaagaagggga	0.617000													3	4					0	0	0.004672	0	0
SIGLEC1	6614	broad.mit.edu	37	20	3687267	3687267	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:3687267G>A	ENST00000344754.4	-	2	135	c.136C>T	c.(136-138)Cct>Tct	p.P46S	SIGLEC1_ENST00000202578.4_Missense_Mutation_p.P46S	NM_023068.3	NP_075556.1	Q9BZZ2	SN_HUMAN	sialic acid binding Ig-like lectin 1, sialoadhesin	46	Ig-like V-type.				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(5)|liver(2)|lung(24)|ovary(3)|pancreas(4)|prostate(3)|skin(8)|upper_aerodigestive_tract(1)	70						ACGTCGGCAGGGAAGCTGAAG	0.657000													3	11					0	0	0.004672	0	0
PRPF19	27339	broad.mit.edu	37	11	60668840	60668840	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:60668840C>T	ENST00000227524.4	-	8	774	c.567_splice	c.e8-1	p.R190_splice		NM_014502.4	NP_055317.1	Q9UMS4	PRP19_HUMAN	pre-mRNA processing factor 19	190					DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|urinary_tract(1)	22						AGTCTTCCCTCTCTGAGAAAA	0.557000													12	15					0	0	0.000978	0	0
GPR32	2854	broad.mit.edu	37	19	51274811	51274811	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:51274811C>T	ENST00000270590.4	+	1	1091	c.954C>T	c.(952-954)ttC>ttT	p.F318F		NM_001506.1	NP_001497.1	O75388	GPR32_HUMAN	G protein-coupled receptor 32	318						integral to plasma membrane	N-formyl peptide receptor activity			breast(4)|endometrium(4)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	29		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		TCTACGTCTTCGTTGGCAGAG	0.542000													30	36					0	0	0.002096	0	0
IGKV1-5	28299	broad.mit.edu	37	2	89247291	89247291	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:89247291C>T	ENST00000496168.1	-	0	184																											ACCCTCATGTCCATGCTGTGT	0.547000													44	104					0	0	0.003610	0	0
ANKRD33	341405	broad.mit.edu	37	12	52284460	52284460	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:52284460C>T	ENST00000301190.6	+	5	957	c.730C>T	c.(730-732)Cgg>Tgg	p.R244W	ANKRD33_ENST00000547119.1_3'UTR|ANKRD33_ENST00000538991.1_Missense_Mutation_p.R50W|ANKRD33_ENST00000340970.4_Missense_Mutation_p.R119W	NM_001130015.1|NM_182608.3	NP_001123487.1|NP_872414.3	Q7Z3H0	ANR33_HUMAN	ankyrin repeat domain 33	119								p.R244W(1)		endometrium(2)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|skin(1)|urinary_tract(1)	22				BRCA - Breast invasive adenocarcinoma(357;0.0969)		GTGGAGGATTCGGCAGCTGCT	0.672000													12	34					0	0	0.001855	0	0
SNORD114-26	767606	broad.mit.edu	37	14	101453403	101453403	+	RNA	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:101453403G>A	ENST00000363543.1	+	0	21					NR_003219.1																						ATGAGCACTGGTGGAGTATGA	0.388000													24	34					0	0	0.001512	0	0
PRKAR1B	5575	broad.mit.edu	37	7	590155	590155	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:590155G>A	ENST00000406797.1	-	11	1232	c.1058C>T	c.(1057-1059)cCc>cTc	p.P353L	PRKAR1B_ENST00000403562.1_Missense_Mutation_p.P353L|PRKAR1B_ENST00000360274.4_Missense_Mutation_p.P353L|PRKAR1B_ENST00000544935.1_Missense_Mutation_p.P353L|PRKAR1B_ENST00000537384.1_Missense_Mutation_p.P353L	NM_001164761.1	NP_001158233.1	P31321	KAP1_HUMAN	protein kinase, cAMP-dependent, regulatory, type I, beta	353					activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|protein phosphorylation|regulation of insulin secretion|transmembrane transport|water transport	cAMP-dependent protein kinase complex|cytosol	cAMP binding|cAMP-dependent protein kinase regulator activity			endometrium(4)|large_intestine(1)|liver(1)|lung(10)|prostate(1)	17		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|Epithelial(4;5.75e-19)|OV - Ovarian serous cystadenocarcinoma(56;2.01e-18)|all cancers(6;3.96e-16)|BRCA - Breast invasive adenocarcinoma(126;0.152)		CTCGAAGCGGGGCCGGTCCAG	0.642000													8	13					0	0	0.003080	0	0
M1AP	130951	broad.mit.edu	37	2	74787386	74787386	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:74787386G>A	ENST00000290536.5	-	9	1430	c.1314C>T	c.(1312-1314)acC>acT	p.T438T	M1AP_ENST00000464686.1_5'UTR|M1AP_ENST00000358434.2_Silent_p.T87T|M1AP_ENST00000409585.1_Silent_p.T438T|M1AP_ENST00000536235.1_Silent_p.T438T	NM_138804.3	NP_620159.2			meiosis 1 associated protein																		AGGGGTTGTAGGTGGGCTCCA	0.572000													50	27					0	0	0.003610	0	0
PSMB8	5696	broad.mit.edu	37	6	32811717	32811717	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32811717G>A	ENST00000374882.3	-	1	107	c.57C>T	c.(55-57)ctC>ctT	p.L19L	PSMB8_ENST00000395339.3_Silent_p.L19L|PSMB8_ENST00000374881.2_Intron	NM_148919.3	NP_683720.2	P28062	PSB8_HUMAN	proteasome (prosome, macropain) subunit, beta type, 8	19					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|type I interferon-mediated signaling pathway|viral reproduction	cytoplasm|nucleus|proteasome core complex	protein binding|threonine-type endopeptidase activity			NS(1)|cervix(1)|kidney(1)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(1)	11						CCGCAACCGGGAGAGCCGATT	0.652000													24	170					0	0	0.004656	0	0
PRDM14	63978	broad.mit.edu	37	8	70971050	70971050	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:70971050C>T	ENST00000276594.2	-	6	1412	c.1211G>A	c.(1210-1212)aGa>aAa	p.R404K		NM_024504.3	NP_078780.1	Q9GZV8	PRD14_HUMAN	PR domain containing 14	404					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(13)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32	Breast(64;0.193)		Epithelial(68;0.00508)|all cancers(69;0.0259)|OV - Ovarian serous cystadenocarcinoma(28;0.0405)			CTTCCCACATCTTTCACATCT	0.428000													19	79					0	0	0.002299	0	0
CEP250	11190	broad.mit.edu	37	20	34055193	34055193	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:34055193C>A	ENST00000397527.1	+	9	1384	c.664C>A	c.(664-666)Cgc>Agc	p.R222S	CEP250_ENST00000342580.4_Missense_Mutation_p.R222S|CEP250_ENST00000397524.1_Missense_Mutation_p.R222S	NM_007186.3	NP_009117.2	Q9BV73	CP250_HUMAN	centrosomal protein 250kDa	222					centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CTGTTGTCTGCGCTTGACTGT	0.552000													43	129					3.77016e-25	6.45867e-25	0.003214	1	0
BANK1	55024	broad.mit.edu	37	4	102994886	102994886	+	Missense_Mutation	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:102994886A>G	ENST00000504592.1	+	20	2717	c.2299A>G	c.(2299-2301)Aag>Gag	p.K767E	BANK1_ENST00000322953.4_Missense_Mutation_p.K782E|BANK1_ENST00000508653.1_Missense_Mutation_p.K649E|BANK1_ENST00000428908.1_Missense_Mutation_p.K649E|BANK1_ENST00000444316.2_Missense_Mutation_p.K752E			Q8NDB2	BANK1_HUMAN	B-cell scaffold protein with ankyrin repeats 1	782					B cell activation					NS(1)|breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|liver(2)|lung(16)|ovary(2)|skin(2)|urinary_tract(1)	44		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;2.7e-07)		TTTCTGTTGCAAGAAAGATCA	0.318000													22	31					0	0	0.003954	0	0
BZRAP1	9256	broad.mit.edu	37	17	56386068	56386068	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:56386068G>A	ENST00000355701.3	-	22	5435	c.4565C>T	c.(4564-4566)cCt>cTt	p.P1522L	BZRAP1_ENST00000343736.4_Missense_Mutation_p.P1522L|BZRAP1_ENST00000268893.6_Missense_Mutation_p.P1462L	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1522						mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCCATCTCCAGGGTAGCAGGA	0.627000													33	15					0	0	0.002096	0	0
HIVEP2	3097	broad.mit.edu	37	6	143091889	143091889	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:143091889G>A	ENST00000367603.2	-	5	4729	c.3987C>T	c.(3985-3987)ctC>ctT	p.L1329L	HIVEP2_ENST00000012134.2_Silent_p.L1329L|HIVEP2_ENST00000367604.1_Silent_p.L1329L	NM_006734.3	NP_006725.3	P31629	ZEP2_HUMAN	human immunodeficiency virus type I enhancer binding protein 2	1329					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(2)|breast(4)|central_nervous_system(6)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(19)|lung(35)|ovary(4)|prostate(6)|skin(4)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	100				OV - Ovarian serous cystadenocarcinoma(155;1.61e-05)|GBM - Glioblastoma multiforme(68;0.0102)		CTGTTCCTGGGAGGGACTGCA	0.498000													28	20					0	0	0.005443	0	0
MED12L	116931	broad.mit.edu	37	3	150911442	150911442	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:150911442C>T	ENST00000474524.1	+	14	2172	c.2134C>T	c.(2134-2136)Cct>Tct	p.P712S	MED12L_ENST00000422248.2_Missense_Mutation_p.P712S|MED12L_ENST00000273432.4_Missense_Mutation_p.P572S|MED12L_ENST00000309237.4_Missense_Mutation_p.P747S	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	712					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AACACATTTTCCTATACCTCT	0.338000													22	68					0	0	0.003330	0	0
MXRA5	25878	broad.mit.edu	37	X	3239522	3239522	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:3239522C>T	ENST00000217939.6	-	5	4358	c.4204G>A	c.(4204-4206)Gaa>Aaa	p.E1402K		NM_015419.3	NP_056234.2	Q9NR99	MXRA5_HUMAN	matrix-remodelling associated 5	1402						extracellular region				NS(1)|biliary_tract(1)|breast(4)|central_nervous_system(3)|cervix(2)|endometrium(8)|kidney(2)|large_intestine(32)|lung(81)|ovary(6)|prostate(3)|skin(9)|stomach(3)|urinary_tract(2)	157		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTAAGATTTTCCCCAGAAGTG	0.507000													8	2					0	0	0.003080	0	0
SRF	6722	broad.mit.edu	37	6	43146877	43146877	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43146877C>T	ENST00000265354.4	+	7	1834	c.1476C>T	c.(1474-1476)acC>acT	p.T492T	SRF_ENST00000457278.2_Silent_p.T288T	NM_003131.2	NP_003122.1	P11831	SRF_HUMAN	serum response factor (c-fos serum response element-binding transcription factor)	492					angiogenesis involved in wound healing|cell migration involved in sprouting angiogenesis|cellular senescence|heart looping|muscle cell homeostasis|neuron development|positive regulation of cell differentiation|positive regulation of smooth muscle contraction|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription via serum response element binding|regulation of smooth muscle cell differentiation|response to cytokine stimulus|response to hormone stimulus|response to toxin|transcription from RNA polymerase II promoter|trophectodermal cell differentiation	endoplasmic reticulum	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|serum response element binding|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)	12			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.011)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			GCAACCTCACCGAGCTACAGG	0.622000													16	76					0	0	0.006122	0	0
FANCF	2188	broad.mit.edu	37	11	22646373	22646373	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:22646373G>A	ENST00000327470.3	-	1	1014	c.984C>T	c.(982-984)gcC>gcT	p.A328A		NM_022725.3	NP_073562.1	Q9NPI8	FANCF_HUMAN	Fanconi anemia, complementation group F	328					DNA repair	nucleoplasm	protein binding			kidney(3)|large_intestine(3)|lung(6)|skin(1)	13						AGGTCTCCAGGGCAGTTAGAA	0.478000			"""N, F"""			"""AML, leukemia"""		Involved in tolerance or repair of DNA crosslinks	Fanconi Anemia		OREG0020844	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	59					0	0	0.002852	0	0
TET3	200424	broad.mit.edu	37	2	74317148	74317148	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:74317148C>T	ENST00000409262.3	+	5	2608	c.2608C>T	c.(2608-2610)Cgc>Tgc	p.R870C		NM_144993.1	NP_659430.1	O43151	TET3_HUMAN	tet methylcytosine dioxygenase 3	870							metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			NS(1)|breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TCGCAAGTTCCGCCTCGCAGG	0.597000													34	102					0	0	0.003271	0	0
ICK	22858	broad.mit.edu	37	6	52874239	52874239	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:52874239G>A	ENST00000356971.3	-	13	2108	c.1619C>T	c.(1618-1620)tCa>tTa	p.S540L	ICK_ENST00000350082.5_Missense_Mutation_p.S540L	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	540					intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					TTACTCACCTGAATTTACTTT	0.448000													21	145					0	0	0.002780	0	0
HEATR1	55127	broad.mit.edu	37	1	236746319	236746319	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:236746319G>A	ENST00000366582.3	-	18	2533	c.2419C>T	c.(2419-2421)Cct>Tct	p.P807S	HEATR1_ENST00000366581.2_Missense_Mutation_p.P807S	NM_018072.5	NP_060542.4	Q9H583	HEAT1_HUMAN	HEAT repeat containing 1	807					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			NS(2)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(18)|lung(28)|ovary(3)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(3)	87	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TTACCTTTAGGAAAAGATTTA	0.383000													60	29					0	0	0.003610	0	0
ZBTB9	221504	broad.mit.edu	37	6	33423517	33423517	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:33423517G>A	ENST00000395064.2	+	2	908	c.640G>A	c.(640-642)Gaa>Aaa	p.E214K		NM_152735.3	NP_689948.1	Q96C00	ZBTB9_HUMAN	zinc finger and BTB domain containing 9	214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|lung(6)|skin(1)|upper_aerodigestive_tract(2)	11						ggtggaagaagaagaggagga	0.552000													21	123					0	0	0.001523	0	0
OR1N2	138882	broad.mit.edu	37	9	125316009	125316009	+	Silent	SNP	C	C	G	rs140908671		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:125316009C>G	ENST00000373688.2	+	1	619	c.561C>G	c.(559-561)gcC>gcG	p.A187A		NM_001004457.1	NP_001004457.1	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N, member 2	187					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(3)	26						CTTTCTGTGCCCAGAAAGCCA	0.537000													39	8					0	0	0.004878	0	0
SERPINB3	6317	broad.mit.edu	37	18	61323175	61323175	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:61323175C>T	ENST00000283752.5	-	8	1032	c.889G>A	c.(889-891)Gac>Aac	p.D297N	SERPINB11_ENST00000489748.1_RNA|SERPINB3_ENST00000332821.8_Missense_Mutation_p.D245N	NM_006919.2	NP_008850.1	P29508	SPB3_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 3	297					regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity	p.D297N(1)		breast(2)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(14)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	36						CTCAACGTGTCCTTGAGGTCA	0.488000													31	35					0	0	0.003755	0	0
HPCAL4	51440	broad.mit.edu	37	1	40148263	40148263	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:40148263G>A	ENST00000372844.3	-	4	912	c.521C>T	c.(520-522)gCa>gTa	p.A174V		NM_016257.2	NP_057341.1	Q9UM19	HPCL4_HUMAN	hippocalcin like 4	174	EF-hand 4.				central nervous system development	intracellular	calcium ion binding			breast(1)|central_nervous_system(1)|lung(5)|stomach(1)	8	all_cancers(7;4.65e-13)|Lung NSC(20;2.88e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;4.3e-17)|all cancers(16;8.48e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)			ACTCTTGGCTGCCTCCTTGAA	0.567000													21	70					0	0	0.004656	0	0
RNF40	9810	broad.mit.edu	37	16	30777704	30777704	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:30777704C>T	ENST00000324685.6	+	10	1553	c.1118C>T	c.(1117-1119)gCc>gTc	p.A373V	RNF40_ENST00000402121.3_Intron|RNF40_ENST00000357890.5_Intron|RNF40_ENST00000563683.1_Missense_Mutation_p.A333V	NM_001207033.1|NM_014771.3	NP_001193962.1|NP_055586.1	O75150	BRE1B_HUMAN	ring finger protein 40, E3 ubiquitin protein ligase	373					histone H2B ubiquitination|histone monoubiquitination|ubiquitin-dependent protein catabolic process	nucleus|synaptosome|ubiquitin ligase complex	protein homodimerization activity|ubiquitin protein ligase binding|zinc ion binding			central_nervous_system(2)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(6)|lung(10)|prostate(2)	30			Colorectal(24;0.198)			CCCCAGGTGGCCCTGCGGAGC	0.617000													28	38					0	0	0.003271	0	0
ZNF454	285676	broad.mit.edu	37	5	178392003	178392003	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:178392003C>T	ENST00000320129.3	+	5	901	c.598C>T	c.(598-600)Cat>Tat	p.H200Y	ZNF454_ENST00000519564.1_Missense_Mutation_p.H200Y	NM_001178090.1|NM_182594.2	NP_001171561.1|NP_872400.2	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	200					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(11)|lung(18)|ovary(2)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)	46	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		TCAGAAAATTCATAATGAAAA	0.343000													27	39					0	0	0.005443	0	0
GTF3C1	2975	broad.mit.edu	37	16	27475829	27475829	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:27475829G>A	ENST00000356183.4	-	34	5699	c.5684C>T	c.(5683-5685)cCc>cTc	p.P1895L	GTF3C1_ENST00000561623.1_Missense_Mutation_p.P1895L	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1895						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						CCCAAGGCTGGGGGCCAAATT	0.667000													29	69					0	0	0.001786	0	0
R3HDM2	22864	broad.mit.edu	37	12	57677620	57677620	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:57677620C>T	ENST00000402412.1	-	13	1548	c.1158G>A	c.(1156-1158)agG>agA	p.R386R	RP11-123K3.4_ENST00000548184.1_RNA|R3HDM2_ENST00000403821.2_Silent_p.R372R|R3HDM2_ENST00000347140.3_Silent_p.R372R|R3HDM2_ENST00000393811.2_Silent_p.R99R|R3HDM2_ENST00000358907.2_Silent_p.R372R|R3HDM2_ENST00000413953.2_Silent_p.R99R|R3HDM2_ENST00000441731.2_Silent_p.R33R			Q9Y2K5	R3HD2_HUMAN	R3H domain containing 2	372						nucleus	nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(3)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	22						GCCTGGAGATCCTTCCCGCAC	0.488000													65	129					0	0	0.003610	0	0
CCDC39	339829	broad.mit.edu	37	3	180372596	180372596	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:180372596G>A	ENST00000273654.4	-	13	1755	c.1136C>T	c.(1135-1137)aCg>aTg	p.T379M	CCDC39_ENST00000442201.2_Missense_Mutation_p.T295M			Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	295					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton		p.T379K(1)|p.T295K(1)		NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			CTGATATGCCGTTCTACATTT	0.353000													11	31					0	0	0.001855	0	0
GBP5	115362	broad.mit.edu	37	1	89730416	89730416	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:89730416T>A	ENST00000343435.5	-	8	1638	c.1102A>T	c.(1102-1104)Aaa>Taa	p.K368*	GBP5_ENST00000370459.3_Nonsense_Mutation_p.K368*|RP4-620F22.2_ENST00000437128.1_RNA|GBP5_ENST00000481145.1_5'UTR	NM_001134486.2|NM_052942.3	NP_001127958.1|NP_443174.1	Q96PP8	GBP5_HUMAN	guanylate binding protein 5	368						plasma membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		AAAGAGTTTTTCATGAAGACT	0.463000													32	30					0	0	0.002836	0	0
FAT2	2196	broad.mit.edu	37	5	150946847	150946847	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:150946847G>A	ENST00000261800.5	-	1	1658	c.1646C>T	c.(1645-1647)tCc>tTc	p.S549F		NM_001447.2	NP_001438.1	Q9NYQ8	FAT2_HUMAN	FAT atypical cadherin 2	549	Cadherin 4.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			NS(6)|breast(3)|central_nervous_system(3)|cervix(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(61)|liver(1)|lung(60)|ovary(6)|prostate(5)|skin(5)|stomach(2)|upper_aerodigestive_tract(11)|urinary_tract(1)	196		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AAGAAAAATGGACACTTCCTT	0.473000													23	124					0	0	0.003954	0	0
ZNF676	163223	broad.mit.edu	37	19	22363276	22363276	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:22363276G>A	ENST00000397121.2	-	3	1560	c.1243C>T	c.(1243-1245)Cat>Tat	p.H415Y		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	415					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				TCTCCAGTATGAATTCTCTTA	0.433000													21	23					0	0	0.003954	0	0
DCAF4	26094	broad.mit.edu	37	14	73420935	73420935	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:73420935C>T	ENST00000553457.1	+	9	862	c.572C>T	c.(571-573)tCc>tTc	p.S191F	DCAF4_ENST00000394234.2_Missense_Mutation_p.S191F|DCAF4_ENST00000358377.2_Missense_Mutation_p.S291F|DCAF4_ENST00000555042.1_Missense_Mutation_p.S292F|DCAF4_ENST00000509153.1_Missense_Mutation_p.S231F|DCAF4_ENST00000353777.3_Intron			Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4	291						CUL4 RING ubiquitin ligase complex				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|skin(1)	22						TGTGCCTGGTCCCTGAATATC	0.547000													68	102					0	0	0.003610	0	0
VCPIP1	80124	broad.mit.edu	37	8	67547158	67547158	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:67547158G>A	ENST00000310421.4	-	3	3505	c.3247C>T	c.(3247-3249)Cga>Tga	p.R1083*		NM_025054.4	NP_079330.2	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex interacting protein 1	1083					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity	p.R1083*(1)		breast(7)|central_nervous_system(2)|cervix(2)|endometrium(3)|kidney(6)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	45		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			GGAGCTATTCGAATAAGCTCA	0.403000													20	100					0	0	0.007413	0	0
BOC	91653	broad.mit.edu	37	3	113002451	113002451	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:113002451C>T	ENST00000495514.1	+	16	3329	c.2625C>T	c.(2623-2625)ttC>ttT	p.F875F	BOC_ENST00000273395.4_Silent_p.F876F|BOC_ENST00000355385.3_Silent_p.F875F			Q9BWV1	BOC_HUMAN	BOC cell adhesion associated, oncogene regulated	875					cell adhesion|muscle cell differentiation|positive regulation of myoblast differentiation	integral to membrane|plasma membrane	protein binding			NS(1)|breast(1)|central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(17)|lung(18)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	68			Epithelial(53;0.227)			TCATCCCCTTCTGCTTGTGGA	0.597000													23	51					0	0	0.003330	0	0
TRIM48	79097	broad.mit.edu	37	11	55036761	55036761	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:55036761G>A	ENST00000417545.2	+	5	708	c.622G>A	c.(622-624)Gcg>Acg	p.A208T		NM_024114.3	NP_077019.2	Q8IWZ4	TRI48_HUMAN	tripartite motif containing 48	192						intracellular	zinc ion binding			endometrium(13)|lung(19)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	38						TCTGAATCTAGCGCTCAGGGC	0.493000													22	22					0	0	0.005443	0	0
ABCB4	5244	broad.mit.edu	37	7	87042978	87042978	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:87042978C>T	ENST00000265723.4	-	22	2849	c.2738G>A	c.(2737-2739)aGa>aAa	p.R913K	ABCB4_ENST00000545634.1_Missense_Mutation_p.R913K|ABCB4_ENST00000453593.1_Missense_Mutation_p.R913K|ABCB4_ENST00000359206.3_Missense_Mutation_p.R913K|ABCB4_ENST00000358400.3_Missense_Mutation_p.R913K	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	913	ABC transmembrane type-1 2.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TTCAAATTTTCTTTCCTGGGT	0.358000													31	47					0	0	0.002836	0	0
CHRNB3	1142	broad.mit.edu	37	8	42586909	42586909	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:42586909C>A	ENST00000289957.2	+	5	587	c.459C>A	c.(457-459)tgC>tgA	p.C153*		NM_000749.3	NP_000740.1	Q05901	ACHB3_HUMAN	cholinergic receptor, nicotinic, beta 3 (neuronal)	153					synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	nicotinic acetylcholine-activated cation-selective channel activity|receptor activity			endometrium(4)|large_intestine(7)|lung(7)|ovary(2)|prostate(1)|skin(2)|urinary_tract(2)	25	all_lung(13;5.7e-12)|Lung NSC(13;1.6e-10)|Ovarian(28;0.00579)|Prostate(17;0.0119)|Lung SC(25;0.184)	all_lung(54;0.00026)|Lung NSC(58;0.000992)|Hepatocellular(245;0.0524)|Renal(179;0.0822)|Esophageal squamous(32;0.0954)	Lung(22;0.0199)|LUSC - Lung squamous cell carcinoma(45;0.0869)			AAAGCTCCTGCACCATGGACG	0.527000													15	24					1.49906e-05	2.54368e-05	0.002450	1	0
TRMT1	55621	broad.mit.edu	37	19	13220601	13220601	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:13220601G>A	ENST00000592062.1	-	11	1728	c.1158C>T	c.(1156-1158)caC>caT	p.H386H	TRMT1_ENST00000357720.4_Silent_p.H386H|TRMT1_ENST00000221504.8_Silent_p.H357H|TRMT1_ENST00000437766.1_Silent_p.H386H			Q9NXH9	TRM1_HUMAN	tRNA methyltransferase 1 homolog (S. cerevisiae)	386							RNA binding|tRNA (guanine-N2-)-methyltransferase activity|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(1)	14			OV - Ovarian serous cystadenocarcinoma(19;6.08e-22)	GBM - Glioblastoma multiforme(1328;0.0356)		GTTGCCCACAGTGTTCACACT	0.627000													15	30					0	0	0.004990	0	0
GRWD1	83743	broad.mit.edu	37	19	48953957	48953957	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:48953957C>T	ENST00000253237.5	+	5	950	c.717C>T	c.(715-717)atC>atT	p.I239I		NM_031485.3	NP_113673.3	Q9BQ67	GRWD1_HUMAN	glutamate-rich WD repeat containing 1	239						nucleolus				endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|stomach(1)	19		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000206)|all cancers(93;0.000207)|Epithelial(262;0.0125)|GBM - Glioblastoma multiforme(486;0.0222)		AAAAGAACATCCACCTCTGGA	0.647000													13	16					0	0	0.002450	0	0
DNASE1L3	1776	broad.mit.edu	37	3	58190533	58190533	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:58190533C>T	ENST00000483681.1	-	6	977	c.396G>A	c.(394-396)agG>agA	p.R132R	DNASE1L3_ENST00000486455.1_Silent_p.R102R|DNASE1L3_ENST00000394549.2_Silent_p.R132R|DNASE1L3_ENST00000318316.3_Silent_p.R132R			Q13609	DNSL3_HUMAN	deoxyribonuclease I-like 3	132					apoptosis|DNA catabolic process	nucleus	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			breast(2)|large_intestine(4)|lung(6)	12				BRCA - Breast invasive adenocarcinoma(55;0.00021)|KIRC - Kidney renal clear cell carcinoma(284;0.0445)|Kidney(284;0.0556)|OV - Ovarian serous cystadenocarcinoma(275;0.202)		CAAAGGGCTCCCTGGAAAACA	0.527000													14	26					0	0	0.004007	0	0
SLC7A13	157724	broad.mit.edu	37	8	87229720	87229720	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:87229720G>A	ENST00000297524.3	-	3	1261	c.1158C>T	c.(1156-1158)ccC>ccT	p.P386P	SLC7A13_ENST00000419776.2_Silent_p.P377P	NM_138817.2	NP_620172.2	Q8TCU3	S7A13_HUMAN	solute carrier family 7 (anionic amino acid transporter), member 13	386						integral to membrane	amino acid transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(24)|ovary(1)|pancreas(1)|prostate(1)|skin(3)	45						TAGATAGATTGGGTTCCTGGT	0.284000													19	81					0	0	0.001523	0	0
OR8J1	219477	broad.mit.edu	37	11	56128611	56128611	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:56128611G>A	ENST00000303039.3	+	1	921	c.889G>A	c.(889-891)Gat>Aat	p.D297N		NM_001005205.2	NP_001005205.2	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J, member 1	297					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	47	Esophageal squamous(21;0.00448)					GAGGAATAAGGATGTGAAGAC	0.363000													19	153					0	0	0.001523	0	0
RADIL	55698	broad.mit.edu	37	7	4856006	4856006	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:4856006C>T	ENST00000399583.3	-	8	2006	c.1819G>A	c.(1819-1821)Gag>Aag	p.E607K	RADIL_ENST00000536091.1_3'UTR|RADIL_ENST00000538469.1_Missense_Mutation_p.E367K	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	607	Dilute.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CGCAGCTCCTCGGGCAGTTCG	0.701000													40	65					0	0	0.002522	0	0
SBSPON	157869	broad.mit.edu	37	8	73993430	73993430	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:73993430C>T	ENST00000297354.6	-	2	437	c.233G>A	c.(232-234)gGg>gAg	p.G78E	SBSPON_ENST00000519697.1_5'UTR	NM_153225.3	NP_694957.3	Q8IVN8	RPESP_HUMAN	somatomedin B and thrombospondin, type 1 domain containing	78	TSP type-1.				immune response	extracellular region	polysaccharide binding|scavenger receptor activity										GCTCCATTCCCCCACGAAGCA	0.632000													10	63					0	0	0.000673	0	0
ZIM3	114026	broad.mit.edu	37	19	57646987	57646987	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57646987G>A	ENST00000269834.1	-	5	1103	c.718C>T	c.(718-720)Caa>Taa	p.Q240*		NM_052882.1	NP_443114.1	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	240					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(27)|pancreas(1)|prostate(3)|skin(1)|urinary_tract(1)	52		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TTCTGATGTTGAAAGAGATTT	0.383000													39	79					0	0	0.006230	0	0
AOC4P	90586	broad.mit.edu	37	17	41020661	41020661	+	RNA	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:41020661G>A	ENST00000585538.1	+	0	1500					NR_002773.1																						GGGCCTTGCGGAAACGGTGCT	0.507000													21	14					0	0	0.001523	0	0
MGRN1	23295	broad.mit.edu	37	16	4731613	4731613	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:4731613C>T	ENST00000399577.5	+	13	1287	c.1194C>T	c.(1192-1194)ctC>ctT	p.L398L	MGRN1_ENST00000262370.7_Silent_p.L398L|MGRN1_ENST00000415496.1_Silent_p.L377L|MGRN1_ENST00000586183.1_Silent_p.L376L|MGRN1_ENST00000588994.1_Silent_p.L376L	NM_001142290.2	NP_001135762.1	O60291	MGRN1_HUMAN	mahogunin ring finger 1, E3 ubiquitin protein ligase	398					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(2)|lung(4)|ovary(3)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	18						TCAACGGCCTCCGGGCTGTCT	0.657000													18	23					0	0	0.001882	0	0
GALNT12	79695	broad.mit.edu	37	9	101589065	101589065	+	Silent	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:101589065T>A	ENST00000375011.3	+	3	573	c.573T>A	c.(571-573)ctT>ctA	p.L191L		NM_024642.4	NP_078918.3	Q8IXK2	GLT12_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12)	191	Catalytic subdomain A.					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)|endometrium(2)|large_intestine(3)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	17		Acute lymphoblastic leukemia(62;0.0559)				CCAATGAGCTTTCGGGACTGC	0.647000													16	2					0	0	0.004990	0	0
KCNMB1	3779	broad.mit.edu	37	5	169810806	169810806	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:169810806C>T	ENST00000274629.4	-	3	625	c.183G>A	c.(181-183)agG>agA	p.R61R	KCNIP1_ENST00000377360.4_Intron|KCNMB1_ENST00000521859.1_Silent_p.R61R|KCNIP1_ENST00000518527.1_Intron	NM_004137.3	NP_004128.1	Q16558	KCMB1_HUMAN	potassium large conductance calcium-activated channel, subfamily M, beta member 1	61					platelet activation|synaptic transmission		calcium-activated potassium channel activity|potassium channel regulator activity			endometrium(1)|large_intestine(1)|lung(7)|ovary(2)	11	Renal(175;0.000159)|Lung NSC(126;0.0165)|all_lung(126;0.026)	Medulloblastoma(196;0.0109)|all_neural(177;0.0146)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.175)		CCTCCTGGTCCCTGATGTTGG	0.582000													20	28					0	0	0.001216	0	0
GYS2	2998	broad.mit.edu	37	12	21699379	21699379	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:21699379G>A	ENST00000261195.2	-	12	1702	c.1448C>T	c.(1447-1449)tCc>tTc	p.S483F		NM_021957.3	NP_068776.2	P54840	GYS2_HUMAN	glycogen synthase 2 (liver)	483			S -> P (in GSD0).		glucose metabolic process|glycogen biosynthetic process|response to glucose stimulus	cortical actin cytoskeleton|cytosol|ectoplasm|insoluble fraction|soluble fraction	glycogen (starch) synthase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(5)|kidney(1)|large_intestine(14)|lung(14)|prostate(6)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	48						ACTGGTGGAGGATAGAAACTC	0.363000													12	15					0	0	0.000978	0	0
ATXN1	6310	broad.mit.edu	37	6	16328174	16328174	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:16328174A>C	ENST00000244769.4	-	8	1304	c.368T>G	c.(367-369)cTg>cGg	p.L123R	ATXN1_ENST00000436367.1_Missense_Mutation_p.L123R	NM_000332.3	NP_000323.2	P54253	ATX1_HUMAN	ataxin 1	123					cell death|negative regulation of transcription, DNA-dependent|nuclear export|RNA processing	cytoplasm|nuclear inclusion body|nuclear matrix|nucleoplasm	identical protein binding|poly(G) RNA binding|poly(U) RNA binding|protein binding|protein C-terminus binding|protein self-association			NS(1)|breast(1)|central_nervous_system(2)|cervix(1)|endometrium(2)|kidney(3)|large_intestine(11)|lung(12)|prostate(2)|skin(7)|upper_aerodigestive_tract(2)	44	Breast(50;0.063)|Ovarian(93;0.0733)	all_hematologic(90;0.000682)|Ovarian(999;0.00973)				GGTGTGCGGCAGGTGAGCGTA	0.667000													14	110					0	0	0.002450	0	0
ZNF555	148254	broad.mit.edu	37	19	2852712	2852712	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:2852712C>T	ENST00000334241.4	+	4	787	c.649C>T	c.(649-651)Cgg>Tgg	p.R217W	ZNF555_ENST00000591539.1_Missense_Mutation_p.R216W|AC006130.3_ENST00000589365.1_RNA	NM_001172775.1|NM_152791.4	NP_001166246.1|NP_690004.4	Q8NEP9	ZN555_HUMAN	zinc finger protein 555	217					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(3)|ovary(1)|prostate(1)|skin(3)|urinary_tract(4)	23				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTCCCTCAATCGGCATGTAAG	0.428000													22	29					0	0	0.002299	0	0
OR8H3	390152	broad.mit.edu	37	11	55890640	55890640	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:55890640G>A	ENST00000313472.3	+	1	792	c.792G>A	c.(790-792)aaG>aaA	p.K264K		NM_001005201.1	NP_001005201.1	Q8N146	OR8H3_HUMAN	olfactory receptor, family 8, subfamily H, member 3	264					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(30)|ovary(2)|prostate(1)|skin(3)|stomach(1)	42	Esophageal squamous(21;0.00693)					AGCCAAGAAAGTCTTATTCCT	0.388000													22	200					0	0	0.001523	0	0
THBS3	7059	broad.mit.edu	37	1	155174669	155174669	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:155174669C>T	ENST00000368378.3	-	4	643	c.623G>A	c.(622-624)gGg>gAg	p.G208E	RP11-263K19.4_ENST00000422665.1_RNA|RP11-263K19.4_ENST00000430312.1_RNA|THBS3_ENST00000487250.1_5'UTR|THBS3_ENST00000457183.2_Intron|RP11-263K19.4_ENST00000453136.1_RNA|THBS3_ENST00000428962.2_Intron|THBS3_ENST00000541990.1_Intron	NM_001252607.1|NM_007112.4	NP_001239536.1|NP_009043.1	P49746	TSP3_HUMAN	thrombospondin 3	208					cell-matrix adhesion	extracellular region|perinuclear region of cytoplasm	calcium ion binding|heparin binding|structural molecule activity			breast(6)|endometrium(4)|kidney(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(3)	48	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			GGACTCGTCCCCTTGGAATGG	0.537000													48	161					0	0	0.003610	0	0
GTF3C1	2975	broad.mit.edu	37	16	27475830	27475830	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:27475830G>A	ENST00000356183.4	-	34	5698	c.5683C>T	c.(5683-5685)Ccc>Tcc	p.P1895S	GTF3C1_ENST00000561623.1_Missense_Mutation_p.P1895S	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	1895						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						CCAAGGCTGGGGGCCAAATTT	0.667000													31	70					0	0	0.002445	0	0
INTS1	26173	broad.mit.edu	37	7	1516462	1516462	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:1516462G>A	ENST00000389470.4	-	37	5627	c.5628C>T	c.(5626-5628)atC>atT	p.I1876I	INTS1_ENST00000404767.3_Silent_p.I1677I			Q8N201	INT1_HUMAN	integrator complex subunit 1	1677	Poly-Leu.				snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		GCAGGACTCGGATGCACTGGT	0.657000													10	76					0	0	0.001368	0	0
NRIP1	8204	broad.mit.edu	37	21	16337281	16337281	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:16337281G>A	ENST00000400202.1	-	3	3945	c.3233C>T	c.(3232-3234)tCt>tTt	p.S1078F	NRIP1_ENST00000318948.4_Missense_Mutation_p.S1078F|NRIP1_ENST00000400199.1_Missense_Mutation_p.S1078F			P48552	NRIP1_HUMAN	nuclear receptor interacting protein 1	1078					androgen receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		androgen receptor binding|estrogen receptor binding|glucocorticoid receptor binding|transcription coactivator activity|transcription corepressor activity			cervix(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(13)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	39				Epithelial(23;1.19e-05)|all cancers(11;4.64e-05)|COAD - Colon adenocarcinoma(22;0.000232)|Colorectal(24;0.0006)|OV - Ovarian serous cystadenocarcinoma(11;0.00418)|Lung(58;0.199)|LUSC - Lung squamous cell carcinoma(23;0.24)		ACTGGTAACAGAATTGCCTCC	0.418000													34	135					0	0	0.005524	0	0
ST6GAL1	6480	broad.mit.edu	37	3	186792044	186792044	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:186792044C>T	ENST00000169298.3	+	7	1576	c.902C>T	c.(901-903)cCt>cTt	p.P301L	ST6GAL1_ENST00000457772.2_Missense_Mutation_p.P70L|ST6GAL1_ENST00000448044.1_Missense_Mutation_p.P301L	NM_173216.2	NP_775323.1	P15907	SIAT1_HUMAN	ST6 beta-galactosamide alpha-2,6-sialyltranferase 1	301					humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|upper_aerodigestive_tract(1)	7	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		CCCCAGATGCCTTGGGAGCTA	0.473000													33	103					0	0	0.005524	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54696093	54696093	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:54696093C>T	ENST00000230640.5	+	21	2579	c.2325C>T	c.(2323-2325)ccC>ccT	p.P775P	SKIV2L2_ENST00000545714.1_Silent_p.P674P	NM_015360.4	NP_056175.3	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2 (S. cerevisiae)	775					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			NS(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(5)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	41		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				ACGGCATCCCCTTATTAGACC	0.353000													11	47					0	0	0.001368	0	0
GPI	2821	broad.mit.edu	37	19	34868484	34868484	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:34868484C>T	ENST00000356487.5	+	5	720	c.479C>T	c.(478-480)tCc>tTc	p.S160F	GPI_ENST00000415930.3_Intron|GPI_ENST00000586425.1_Missense_Mutation_p.S160F	NM_000175.3	NP_000166.2	P06744	G6PI_HUMAN	glucose-6-phosphate isomerase	160					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	25	Esophageal squamous(110;0.162)					ATTGGCGGCTCCGACCTGGTG	0.592000													31	95					0	0	0.002836	0	0
CAGE1	285782	broad.mit.edu	37	6	7374037	7374037	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:7374037C>T	ENST00000502583.1	-	5	1579	c.1015G>A	c.(1015-1017)Gaa>Aaa	p.E339K	CAGE1_ENST00000296742.7_Missense_Mutation_p.E203K|CAGE1_ENST00000512086.1_Missense_Mutation_p.E339K|CAGE1_ENST00000379918.4_Missense_Mutation_p.E339K|CAGE1_ENST00000338150.4_Missense_Mutation_p.E339K	NM_001170692.1	NP_001164163.1	Q8TC20	CAGE1_HUMAN	cancer antigen 1	339								p.E339*(1)		breast(1)|cervix(1)|endometrium(3)|kidney(2)|lung(11)|urinary_tract(1)	19	Ovarian(93;0.0418)					ATCTGTAGTTCTTTAACCCTC	0.328000													18	82					0	0	0.007413	0	0
DLGAP3	58512	broad.mit.edu	37	1	35370481	35370481	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:35370481G>A	ENST00000373347.1	-	3	772	c.504C>T	c.(502-504)agC>agT	p.S168S	DLGAP3_ENST00000235180.4_Silent_p.S168S			O95886	DLGP3_HUMAN	discs, large (Drosophila) homolog-associated protein 3	168					cell-cell signaling	cell junction|postsynaptic density|postsynaptic membrane		p.S168R(1)		central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(23)|ovary(4)|prostate(3)|skin(3)|urinary_tract(1)	46		Myeloproliferative disorder(586;0.0393)				GCCGGATGCGGCTAGGGCTCT	0.667000													11	33					0	0	0.002450	0	0
CASR	846	broad.mit.edu	37	3	121976007	121976007	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:121976007C>T	ENST00000498619.1	+	3	703	c.265C>T	c.(265-267)Ccc>Tcc	p.P89S	CASR_ENST00000490131.1_Missense_Mutation_p.P89S|CASR_ENST00000296154.5_Missense_Mutation_p.P89S	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	89					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	AGCCCTTCTTCCCAACTTGAC	0.448000													26	80					0	0	0.004656	0	0
SNX29	92017	broad.mit.edu	37	16	12096892	12096892	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:12096892C>T	ENST00000566228.1	+	3	183	c.114C>T	c.(112-114)tcC>tcT	p.S38S		NM_032167.3	NP_115543.3	Q8TEQ0	SNX29_HUMAN	sorting nexin 29	0					cell communication		phosphatidylinositol binding			endometrium(1)|large_intestine(1)|lung(3)|ovary(1)|prostate(1)	7						CCTCGGATTCCGACAGCAGGT	0.512000													24	37					0	0	0.001786	0	0
SLC15A2	6565	broad.mit.edu	37	3	121634077	121634077	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:121634077G>A	ENST00000489711.1	+	6	920	c.532G>A	c.(532-534)Gag>Aag	p.E178K	SLC15A2_ENST00000295605.2_Missense_Mutation_p.E147K	NM_021082.3	NP_066568.3	Q16348	S15A2_HUMAN	solute carrier family 15 (oligopeptide transporter), member 2	178					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			NS(1)|endometrium(1)|kidney(4)|large_intestine(5)|lung(17)|skin(6)|upper_aerodigestive_tract(2)	36				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	GTTTCAGGCAGAGGAACGGAC	0.448000													13	31					0	0	0.004007	0	0
DCAF11	80344	broad.mit.edu	37	14	24590046	24590046	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:24590046G>A	ENST00000446197.3	+	12	1819		c.e12-1		DCAF11_ENST00000396941.4_Splice_Site|DCAF11_ENST00000396936.1_Splice_Site|DCAF11_ENST00000559115.1_Splice_Site	NM_025230.4	NP_079506.3	Q8TEB1	DCA11_HUMAN	DDB1 and CUL4 associated factor 11							CUL4 RING ubiquitin ligase complex	protein binding										TGGATTCATAGGGTGATGCCC	0.517000													51	71					0	0	0.003610	0	0
POLR1B	84172	broad.mit.edu	37	2	113315512	113315512	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:113315512C>T	ENST00000263331.5	+	8	1764	c.1184C>T	c.(1183-1185)tCt>tTt	p.S395F	POLR1B_ENST00000409894.3_Intron|POLR1B_ENST00000498054.1_3'UTR|POLR1B_ENST00000417433.2_Missense_Mutation_p.S339F|POLR1B_ENST00000537335.1_Missense_Mutation_p.S184F|POLR1B_ENST00000541869.1_Missense_Mutation_p.S433F	NM_019014.4	NP_061887.2	Q9H9Y6	RPA2_HUMAN	polymerase (RNA) I polypeptide B, 128kDa	395					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			breast(3)|endometrium(9)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42						TGGTTAGTGTCTATTAAAATA	0.353000													5	6					0	0	0.000602	0	0
EPPK1	83481	broad.mit.edu	37	8	144941802	144941802	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:144941802G>A	ENST00000525985.1	-	2	5691	c.5620C>T	c.(5620-5622)Cgt>Tgt	p.R1874C				P58107	EPIPL_HUMAN	epiplakin 1	1874						cytoplasm|cytoskeleton	protein binding|structural molecule activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(5)|cervix(1)|endometrium(8)|kidney(4)|large_intestine(2)|lung(30)|ovary(2)|pancreas(1)|prostate(10)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTCCCCACACGAAGTGTGTGC	0.607000													21	101					0	0	0.001523	0	0
IGSF9	57549	broad.mit.edu	37	1	159904007	159904007	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:159904007C>T	ENST00000368094.1	-	9	1274	c.1077G>A	c.(1075-1077)aaG>aaA	p.K359K	IGSF9_ENST00000361509.3_Silent_p.K343K	NM_001135050.1	NP_001128522.1	Q9P2J2	TUTLA_HUMAN	immunoglobulin superfamily, member 9	359	Ig-like 4.					cell junction|integral to membrane|synapse				central_nervous_system(2)|endometrium(8)|kidney(3)|large_intestine(13)|lung(17)|ovary(3)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_hematologic(112;0.0597)	Breast(1374;0.000126)	BRCA - Breast invasive adenocarcinoma(70;0.111)			CCTTTCCATCCTTGGTCCAGC	0.612000													22	10					0	0	0.007291	0	0
SLC10A4	201780	broad.mit.edu	37	4	48490949	48490949	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:48490949C>T	ENST00000273861.4	+	3	1526	c.1307C>T	c.(1306-1308)tCt>tTt	p.S436F		NM_152679.3	NP_689892.1	Q96EP9	NTCP4_HUMAN	solute carrier family 10, member 4	436						integral to membrane	bile acid:sodium symporter activity			central_nervous_system(1)|large_intestine(1)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	6						GCTCAGACTTCTCTCTAAATG	0.353000													33	56					0	0	0.004878	0	0
DOPEY1	23033	broad.mit.edu	37	6	83810447	83810447	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:83810447C>T	ENST00000349129.2	+	4	422	c.162C>T	c.(160-162)taC>taT	p.Y54Y	DOPEY1_ENST00000237163.5_Silent_p.Y54Y|DOPEY1_ENST00000536812.1_Silent_p.Y54Y|DOPEY1_ENST00000369739.3_Silent_p.Y54Y	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	54					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		ATGCAAAGTACCAAGTAGTAC	0.363000													44	71					0	0	0.002222	0	0
WDR49	151790	broad.mit.edu	37	3	167196724	167196724	+	Missense_Mutation	SNP	C	C	T	rs76736291	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:167196724C>T	ENST00000308378.3	-	15	2341	c.2036G>A	c.(2035-2037)cGa>cAa	p.R679Q	WDR49_ENST00000453925.2_Missense_Mutation_p.R644Q|WDR49_ENST00000476376.1_Missense_Mutation_p.R504Q|SERPINI2_ENST00000476257.1_5'UTR|WDR49_ENST00000479765.1_3'UTR	NM_178824.3	NP_849146.1	Q8IV35	WDR49_HUMAN	WD repeat domain 49	679										breast(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	50						CTTGGCTTTTCGTTCATGATG	0.318000													13	35					0	0	0.001368	0	0
ZNF48	197407	broad.mit.edu	37	16	30410152	30410152	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:30410152C>T	ENST00000320159.2	+	2	1957	c.1581C>T	c.(1579-1581)gcC>gcT	p.A527A		NM_001214906.1|NM_001214907.1|NM_001214909.1|NM_152652.2	NP_001201835.1|NP_001201836.1|NP_001201838.1|NP_689865.2	Q96MX3	ZNF48_HUMAN	zinc finger protein 48	527	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(11)|ovary(2)|pancreas(1)|skin(1)	21						TACCCATGGCCCCTCGACCCC	0.662000													22	26					0	0	0.002780	0	0
TUB	7275	broad.mit.edu	37	11	8118894	8118894	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:8118894C>T	ENST00000305253.4	+	8	1213	c.972C>T	c.(970-972)atC>atT	p.I324I	TUB_ENST00000299506.2_Silent_p.I269I|TUB_ENST00000534099.1_Silent_p.I275I	NM_003320.4	NP_003311.2	P50607	TUB_HUMAN	tubby bipartite transcription factor	269					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				breast(1)|cervix(1)|endometrium(9)|large_intestine(7)|lung(5)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	26		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		AATGCCGCATCACTCGGGACA	0.577000													28	47					0	0	0.002096	0	0
DSP	1832	broad.mit.edu	37	6	7585215	7585215	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:7585215G>C	ENST00000379802.3	+	24	8061	c.7720G>C	c.(7720-7722)Ggc>Cgc	p.G2574R	DSP_ENST00000418664.2_Missense_Mutation_p.G1975R	NM_004415.2	NP_004406.2	P15924	DESP_HUMAN	desmoplakin	2574	Globular 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			biliary_tract(1)|breast(6)|central_nervous_system(7)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(16)|liver(2)|lung(27)|ovary(4)|prostate(1)|skin(8)|stomach(3)|upper_aerodigestive_tract(7)|urinary_tract(5)	101	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		CAGCAGCATGGGCAGTGGTGT	0.483000													20	135					0	0	0.001523	0	0
ZNF836	162962	broad.mit.edu	37	19	52658279	52658279	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:52658279C>T	ENST00000322146.8	-	5	3178	c.2657G>A	c.(2656-2658)gGa>gAa	p.G886E	ZNF836_ENST00000597252.1_Missense_Mutation_p.G886E|CTC-471J1.8_ENST00000594362.1_RNA	NM_001102657.1	NP_001096127.1	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	886					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26						AGGTTTTTCTCCAGAATGAAT	0.393000													21	31					0	0	0.002299	0	0
CA2	760	broad.mit.edu	37	8	86386616	86386616	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:86386616G>A	ENST00000285379.5	+	4	645	c.415G>A	c.(415-417)Gga>Aga	p.G139R		NM_000067.2	NP_000058.1	P00918	CAH2_HUMAN	carbonic anhydrase II	139					one-carbon metabolic process	apical part of cell	carbonate dehydratase activity|zinc ion binding			central_nervous_system(2)|cervix(1)|large_intestine(2)|lung(5)|prostate(1)	11					Acetazolamide(DB00819)|Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Brinzolamide(DB01194)|Chlorothiazide(DB00880)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Dorzolamide(DB00869)|Ethinamate(DB01031)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Topiramate(DB00273)|Trichlormethiazide(DB01021)	GCAACCTGATGGACTGGCCGT	0.398000													54	288					0	0	0.003610	0	0
TRAPPC9	83696	broad.mit.edu	37	8	141461204	141461204	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:141461204T>A	ENST00000389328.4	-	2	577	c.563A>T	c.(562-564)aAg>aTg	p.K188M	TRAPPC9_ENST00000438773.2_Missense_Mutation_p.K90M|TRAPPC9_ENST00000389327.3_Missense_Mutation_p.K90M	NM_031466.5	NP_113654.4	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9	90					cell differentiation	endoplasmic reticulum|Golgi apparatus				breast(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(7)|liver(1)|lung(16)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	47						TGGCCAGTCCTTGGCCGAGAA	0.582000													20	83					0	0	0.001882	0	0
FREM1	158326	broad.mit.edu	37	9	14801670	14801670	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:14801670G>A	ENST00000380881.4	-	21	4492	c.3677C>T	c.(3676-3678)tCc>tTc	p.S1226F	FREM1_ENST00000380880.3_Missense_Mutation_p.S1225F|FREM1_ENST00000422223.2_Missense_Mutation_p.S1225F			Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1	1225					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			breast(3)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(40)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	100				GBM - Glioblastoma multiforme(50;3.53e-06)		GAGTTCCATGGAAAAGCTGTG	0.423000													6	29					0	0	0.001168	0	0
FGD6	55785	broad.mit.edu	37	12	95604835	95604835	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:95604835G>A	ENST00000343958.4	-	2	448	c.225C>T	c.(223-225)atC>atT	p.I75I	FGD6_ENST00000549499.1_Silent_p.I75I|FGD6_ENST00000546711.1_Silent_p.I75I	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	75					actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						GGTTCAACATGATTTTCCTTG	0.408000													80	214					0	0	0.003610	0	0
ECE2	9718	broad.mit.edu	37	3	183995965	183995965	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:183995965G>A	ENST00000402825.3	+	6	968	c.968G>A	c.(967-969)tGg>tAg	p.W323*	ECE2_ENST00000404464.3_Nonsense_Mutation_p.W205*|ECE2_ENST00000357474.5_Nonsense_Mutation_p.W251*|ECE2_ENST00000359140.4_Nonsense_Mutation_p.W176*|EIF2B5_ENST00000444495.1_Intron	NM_014693.3	NP_055508.3	O60344	ECE2_HUMAN	endothelin converting enzyme 2	323	Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(11)|lung(13)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(4)	49	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ATTGGTGGTTGGAACATTACG	0.542000													12	53					0	0	0.000978	0	0
ANK1	286	broad.mit.edu	37	8	41577322	41577322	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:41577322G>A	ENST00000396942.1	-	10	1047	c.964C>T	c.(964-966)Cgg>Tgg	p.R322W	ANK1_ENST00000265709.8_Missense_Mutation_p.R355W|ANK1_ENST00000379758.2_Missense_Mutation_p.R322W|ANK1_ENST00000352337.4_Missense_Mutation_p.R322W|ANK1_ENST00000347528.4_Missense_Mutation_p.R322W|ANK1_ENST00000289734.7_Missense_Mutation_p.R322W|ANK1_ENST00000396945.1_Missense_Mutation_p.R322W			P16157	ANK1_HUMAN	ankyrin 1, erythrocytic	322	89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			breast(5)|central_nervous_system(4)|endometrium(9)|kidney(1)|large_intestine(26)|lung(62)|ovary(3)|prostate(5)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	122	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			AACAGGAGCCGGACACAGTCG	0.572000													37	97					0	0	0.006230	0	0
VN1R2	317701	broad.mit.edu	37	19	53762121	53762121	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:53762121C>T	ENST00000341702.3	+	1	577	c.493C>T	c.(493-495)Ctt>Ttt	p.L165F		NM_173856.2	NP_776255.2	Q8NFZ6	VN1R2_HUMAN	vomeronasal 1 receptor 2	165					response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(15)|skin(1)|upper_aerodigestive_tract(1)	31				GBM - Glioblastoma multiforme(134;0.00301)		ATGCAAATTTCTTTTGTATGC	0.453000													23	42					0	0	0.002299	0	0
RNF183	138065	broad.mit.edu	37	9	116060000	116060000	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:116060000G>A	ENST00000478815.1	-	1	2045	c.465C>T	c.(463-465)ttC>ttT	p.F155F	RNF183_ENST00000297894.5_Silent_p.F155F|RNF183_ENST00000441031.3_Silent_p.F155F|RNF183_ENST00000416588.2_Silent_p.F155F			Q96D59	RN183_HUMAN	ring finger protein 183	155						integral to membrane	zinc ion binding			lung(1)|prostate(1)|skin(1)	3						GAGGGTTGCGGAAACACTCCC	0.587000													40	3					0	0	0.003214	0	0
ZBTB12	221527	broad.mit.edu	37	6	31868259	31868259	+	Missense_Mutation	SNP	C	C	T	rs143624178		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31868259C>T	ENST00000375527.2	-	2	999	c.824G>A	c.(823-825)gGg>gAg	p.G275E	C2_ENST00000469372.1_Intron	NM_181842.2	NP_862825.1	Q9Y330	ZBT12_HUMAN	zinc finger and BTB domain containing 12	275	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|lung(5)|prostate(1)|skin(1)	10						CAGGCCCTCCCCTTCTGCATC	0.706000													39	211					0	0	0.001951	0	0
PTK7	5754	broad.mit.edu	37	6	43099757	43099757	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43099757C>T	ENST00000230419.4	+	6	1037	c.816C>T	c.(814-816)ccC>ccT	p.P272P	PTK7_ENST00000471863.1_Silent_p.P272P|PTK7_ENST00000352931.2_Silent_p.P272P|PTK7_ENST00000349241.2_Silent_p.P272P|PTK7_ENST00000345201.2_Silent_p.P272P|PTK7_ENST00000481273.1_Silent_p.P280P	NM_002821.4	NP_002812.2	Q13308	PTK7_HUMAN	protein tyrosine kinase 7	272	Ig-like C2-type 3.				actin cytoskeleton reorganization|canonical Wnt receptor signaling pathway|cell adhesion|cell migration	cell-cell junction|integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(12)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00784)|OV - Ovarian serous cystadenocarcinoma(102;0.0423)			TCTGCAGCCCCCCACACCTCC	0.582000													15	77					0	0	0.001216	0	0
MUC16	94025	broad.mit.edu	37	19	9082689	9082689	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9082689G>A	ENST00000397910.4	-	1	9329	c.9126C>T	c.(9124-9126)ttC>ttT	p.F3042F		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	3043	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGGGGAAAGGAAGCTTGTTT	0.483000													26	52					0	0	0.003954	0	0
ANTXR1	84168	broad.mit.edu	37	2	69420468	69420468	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:69420468G>A	ENST00000303714.4	+	17	1677	c.1353_splice	c.e17-1	p.G452_splice		NM_032208.2	NP_115584.1	Q9H6X2	ANTR1_HUMAN	anthrax toxin receptor 1	452					actin cytoskeleton reorganization|substrate adhesion-dependent cell spreading	filopodium membrane|integral to membrane|lamellipodium membrane	actin filament binding|collagen binding|metal ion binding|protein binding|transmembrane receptor activity			haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	29						TTATTTCAGGGAAAACTCGAT	0.468000									Familial Infantile Hemangioma				26	79					0	0	0.005443	0	0
MEI1	150365	broad.mit.edu	37	22	42099376	42099376	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:42099376C>T	ENST00000401548.3	+	2	256	c.216C>T	c.(214-216)gcC>gcT	p.A72A	MEI1_ENST00000400107.1_5'UTR|MEI1_ENST00000540833.1_5'UTR|MEI1_ENST00000300398.4_5'UTR	NM_152513.3	NP_689726.3	Q5TIA1	MEI1_HUMAN	meiosis inhibitor 1	72							binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(10)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	30						TCCAAGATGCCCTTGTGAGGC	0.433000													6	14					0	0	0.001984	0	0
RAVER1	125950	broad.mit.edu	37	19	10444150	10444150	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:10444150G>A	ENST00000293677.6	-	1	166	c.85C>T	c.(85-87)Ccg>Tcg	p.P29S		NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	12						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			GGGCTCAGCGGGGGCCGGTGA	0.697000													17	21					0	0	0.006122	0	0
WNK1	65125	broad.mit.edu	37	12	994853	994853	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:994853C>T	ENST00000537687.1	+	19	6306	c.5663C>T	c.(5662-5664)cCc>cTc	p.P1888L	WNK1_ENST00000535572.1_Missense_Mutation_p.P1381L|WNK1_ENST00000530271.2_Missense_Mutation_p.P2126L|WNK1_ENST00000340908.4_Missense_Mutation_p.P1221L|WNK1_ENST00000315939.6_Missense_Mutation_p.P1628L	NM_001184985.1|NM_213655.4	NP_001171914.1|NP_998820.3	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1628					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			breast(7)|central_nervous_system(1)|endometrium(3)|kidney(6)|large_intestine(15)|lung(43)|ovary(6)|prostate(3)|skin(7)|stomach(8)|upper_aerodigestive_tract(3)|urinary_tract(2)	104	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			GCTTTGCTTCCCAACCAGCCC	0.478000													25	51					0	0	0.004656	0	0
TNKS1BP1	85456	broad.mit.edu	37	11	57077309	57077309	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57077309C>T	ENST00000532437.1	-	5	3187	c.2876G>A	c.(2875-2877)aGg>aAg	p.R959K	TNKS1BP1_ENST00000358252.3_Missense_Mutation_p.R959K|TNKS1BP1_ENST00000530920.1_5'UTR			Q9C0C2	TB182_HUMAN	tankyrase 1 binding protein 1, 182kDa	959	Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			breast(3)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(24)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	64		all_epithelial(135;0.21)				GCTGTAGTCCCTTATCCAAGC	0.602000													98	114					0	0	0.003610	0	0
LMTK3	114783	broad.mit.edu	37	19	49000690	49000690	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:49000690C>T	ENST00000600059.1	-	11	3863	c.3636G>A	c.(3634-3636)ttG>ttA	p.L1212L	LMTK3_ENST00000270238.3_Silent_p.L1241L					lemur tyrosine kinase 3											breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(9)|prostate(1)	16		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		GTCCCAAGTCCAAGAATAGTC	0.682000													13	35					0	0	0.002450	0	0
OR5M3	219482	broad.mit.edu	37	11	56237335	56237335	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:56237335G>A	ENST00000312240.2	-	1	679	c.639C>T	c.(637-639)atC>atT	p.I213I		NM_001004742.2	NP_001004742.2	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M, member 3	213					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(2)|endometrium(2)|large_intestine(7)|lung(15)|ovary(2)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	37	Esophageal squamous(21;0.00448)					AGTAAGAGATGATAATTACAG	0.443000													15	156					0	0	0.004007	0	0
ZNF813	126017	broad.mit.edu	37	19	53993859	53993859	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:53993859C>T	ENST00000396403.4	+	4	501	c.373C>T	c.(373-375)Cga>Tga	p.R125*	ZNF813_ENST00000396421.4_Intron	NM_001004301.3	NP_001004301.2	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	125					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		TAGTGCAGACCGATATGATCA	0.408000													55	160					0	0	0.003610	0	0
LY75	4065	broad.mit.edu	37	2	160692099	160692099	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:160692099C>T	ENST00000263636.4	-	26	3592	c.3565G>A	c.(3565-3567)Gaa>Aaa	p.E1189K	LY75_ENST00000553424.1_Missense_Mutation_p.E1189K|LY75_ENST00000554112.1_Missense_Mutation_p.E1189K|LY75-CD302_ENST00000504764.1_Missense_Mutation_p.E1189K|LY75-CD302_ENST00000505052.1_Missense_Mutation_p.E1189K	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		CCATTAGTTTCAGCCCAGCGA	0.413000													20	38					0	0	0.001523	0	0
BSN	8927	broad.mit.edu	37	3	49698439	49698439	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:49698439C>T	ENST00000296452.4	+	6	9275	c.9161C>T	c.(9160-9162)cCc>cTc	p.P3054L		NM_003458.3	NP_003449.2	Q9UPA5	BSN_HUMAN	bassoon presynaptic cytomatrix protein	3054					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			breast(8)|central_nervous_system(2)|cervix(2)|endometrium(16)|kidney(3)|large_intestine(17)|lung(37)|ovary(7)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	106				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		TTCCAGCAGCCCCGCTTCCAG	0.682000													10	33					0	0	0.000673	0	0
RHBDL2	54933	broad.mit.edu	37	1	39381234	39381234	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:39381234C>T	ENST00000540558.1	-	3	637	c.395G>A	c.(394-396)gGg>gAg	p.G132E	RHBDL2_ENST00000372990.1_Splice_Site_p.G132_splice|RP5-864K19.4_ENST00000433671.2_RNA|RHBDL2_ENST00000372985.3_Splice_Site_p.G212_splice|RHBDL2_ENST00000289248.2_Splice_Site_p.G132_splice|RHBDL2_ENST00000538156.1_Splice_Site_p.G199_splice			Q9NX52	RHBL2_HUMAN	rhomboid, veinlet-like 2 (Drosophila)	132					proteolysis	integral to membrane|plasma membrane	serine-type endopeptidase activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(3)	8	Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.23e-17)			CATTGCTTACCCAGCATGTAC	0.423000													20	61					0	0	0.001523	0	0
AKAP6	9472	broad.mit.edu	37	14	33147646	33147646	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:33147646C>T	ENST00000280979.4	+	8	3030	c.2860C>T	c.(2860-2862)Cat>Tat	p.H954Y	AKAP6_ENST00000557354.1_Missense_Mutation_p.H954Y|AKAP6_ENST00000557272.1_Missense_Mutation_p.H954Y	NM_004274.4	NP_004265.3	Q13023	AKAP6_HUMAN	A kinase (PRKA) anchor protein 6	954					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			NS(2)|breast(10)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(25)|lung(42)|ovary(5)|pancreas(2)|prostate(3)|skin(9)|urinary_tract(2)	122	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		GTCAAAAGTTCATTCAGTGGG	0.408000													17	28					0	0	0.007413	0	0
EFHB	151651	broad.mit.edu	37	3	19956846	19956846	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:19956846C>T	ENST00000295824.9	-	5	1398	c.1237G>A	c.(1237-1239)Gga>Aga	p.G413R	EFHB_ENST00000344838.4_Missense_Mutation_p.G283R|EFHB_ENST00000498089.1_5'UTR	NM_144715.3	NP_653316.3	Q8N7U6	EFHB_HUMAN	EF-hand domain family, member B	413					signal transduction	proteinaceous extracellular matrix	calcium ion binding			breast(2)|endometrium(4)|kidney(1)|lung(17)|prostate(1)|urinary_tract(1)	26						CCTTCATTTCCTTCTTTAAAT	0.368000													22	52					0	0	0.003330	0	0
MYO18B	84700	broad.mit.edu	37	22	26228894	26228894	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:26228894C>T	ENST00000335473.7	+	16	3240	c.2990C>T	c.(2989-2991)cCt>cTt	p.P997L	MYO18B_ENST00000407587.2_Missense_Mutation_p.P997L|MYO18B_ENST00000536101.1_Missense_Mutation_p.P997L	NM_032608.5	NP_115997.5	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	997	Myosin head-like.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			NS(2)|breast(6)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(27)|liver(2)|lung(60)|ovary(7)|prostate(8)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(2)	146						GAAGGTGTTCCTGTGCAGTTT	0.507000													32	32					0	0	0.005524	0	0
SLC13A2	9058	broad.mit.edu	37	17	26823500	26823500	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:26823500C>T	ENST00000444914.3	+	11	2070	c.1650C>T	c.(1648-1650)gtC>gtT	p.V550V	SLC13A2_ENST00000314669.5_Silent_p.V501V|SLC13A2_ENST00000537681.1_Silent_p.V430V|SLC13A2_ENST00000545060.1_Silent_p.V458V	NM_001145975.1	NP_001139447.1	Q13183	S13A2_HUMAN	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	501			I -> V (in dbSNP:rs11567842).			integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity			breast(2)|endometrium(2)|kidney(1)|large_intestine(8)|lung(10)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	CTCTCTACGTCATGCTCCCCT	0.642000													39	95					0	0	0.006230	0	0
IRF6	3664	broad.mit.edu	37	1	209963884	209963884	+	Missense_Mutation	SNP	C	C	T	rs121434231		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:209963884C>T	ENST00000367021.3	-	7	1188	c.1016G>A	c.(1015-1017)aGa>aAa	p.R339K	IRF6_ENST00000542854.1_Missense_Mutation_p.R244K	NM_006147.3	NP_006138.1	O14896	IRF6_HUMAN	interferon regulatory factor 6	339			R -> I (in VWS).		cell cycle arrest|interferon-gamma-mediated signaling pathway|mammary gland epithelial cell differentiation|negative regulation of cell proliferation|positive regulation of transcription, DNA-dependent|type I interferon-mediated signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			cervix(1)|large_intestine(4)|lung(12)|ovary(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(4)	28				OV - Ovarian serous cystadenocarcinoma(81;0.0351)		CTTCTTTTGTCTCTCAATCAG	0.478000										HNSCC(57;0.16)			19	80					0	0	0.007413	0	0
TRPV5	56302	broad.mit.edu	37	7	142606723	142606723	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:142606723G>A	ENST00000265310.1	-	14	2176	c.1828C>T	c.(1828-1830)Cgc>Tgc	p.R610C		NM_019841.4	NP_062815.2	Q9NQA5	TRPV5_HUMAN	transient receptor potential cation channel, subfamily V, member 5	610					protein tetramerization	apical plasma membrane|integral to plasma membrane	calcium channel activity			NS(1)|breast(2)|central_nervous_system(3)|endometrium(2)|kidney(1)|large_intestine(14)|lung(32)|ovary(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	67	Melanoma(164;0.059)					CACAGGCAGCGAGGCAGCTTC	0.597000													11	12					0	0	0.001368	0	0
TTN	7273	broad.mit.edu	37	2	179413030	179413030	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:179413030A>T	ENST00000589042.1	-	339	93547	c.93323T>A	c.(93322-93324)aTt>aAt	p.I31108N	TTN_ENST00000359218.5_Missense_Mutation_p.I22168N|TTN-AS1_ENST00000419746.1_RNA|TTN-AS1_ENST00000456053.1_RNA|TTN_ENST00000342175.6_Missense_Mutation_p.I22235N|TTN_ENST00000591111.1_Missense_Mutation_p.I29467N|TTN_ENST00000460472.2_Missense_Mutation_p.I22043N|TTN_ENST00000342992.6_Missense_Mutation_p.I28540N|TTN-AS1_ENST00000592750.1_RNA|TTN-AS1_ENST00000592689.1_RNA|TTN-AS1_ENST00000438095.1_RNA|TTN-AS1_ENST00000592600.1_RNA|TTN-AS1_ENST00000591332.1_RNA|TTN-AS1_ENST00000590932.1_RNA|TTN-AS1_ENST00000590807.1_RNA|TTN-AS1_ENST00000586831.1_RNA|TTN-AS1_ENST00000586707.1_RNA|TTN-AS1_ENST00000586452.1_RNA|TTN-AS1_ENST00000585451.1_RNA|TTN-AS1_ENST00000592630.1_RNA	NM_001267550.1	NP_001254479.1	Q8WZ42	TITIN_HUMAN	titin	29467	Ig-like 139.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTGGCTACAATTGGTTCTGG	0.473000													66	58					0	0	0.003610	0	0
FBXL22	283807	broad.mit.edu	37	15	63893549	63893549	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:63893549G>A	ENST00000360587.2	+	2	448	c.408G>A	c.(406-408)ggG>ggA	p.G136G	FBXL22_ENST00000539570.3_Silent_p.G130G|USP3-AS1_ENST00000561256.1_RNA	NM_203373.2	NP_976307.2	Q6P050	FXL22_HUMAN	F-box and leucine-rich repeat protein 22	130										lung(4)	4						CGTCCTCGGGGACTCCGATCG	0.687000													13	18					0	0	0.001368	0	0
SLC17A8	246213	broad.mit.edu	37	12	100784803	100784803	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:100784803G>A	ENST00000323346.5	+	3	692	c.379G>A	c.(379-381)Gaa>Aaa	p.E127K	SLC17A8_ENST00000392989.3_Missense_Mutation_p.E127K	NM_001145288.1|NM_139319.2	NP_001138760.1|NP_647480.1	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 8	127					neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			NS(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	44						CTGGGATCCAGAAACAGTGGG	0.388000													28	70					0	0	0.001512	0	0
HYDIN	54768	broad.mit.edu	37	16	70998635	70998635	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:70998635C>T	ENST00000393567.2	-	37	5934	c.5784G>A	c.(5782-5784)gaG>gaA	p.E1928E		NM_001270974.1	NP_001257903.1	Q4G0P3	HYDIN_HUMAN	HYDIN, axonemal central pair apparatus protein	1928										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				TCTCACCATTCTCCTGTGCCA	0.493000													7	18					0	0	0.000978	0	0
LRRTM1	347730	broad.mit.edu	37	2	80529698	80529698	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:80529698C>T	ENST00000295057.3	-	2	1903	c.1247G>A	c.(1246-1248)gGc>gAc	p.G416D	CTNNA2_ENST00000402739.4_Intron|CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000466387.1_Intron|CTNNA2_ENST00000496558.1_Intron|LRRTM1_ENST00000409148.1_Missense_Mutation_p.G416D|CTNNA2_ENST00000540488.1_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	416						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						GGCGTGCTCGCCGCCTGGAAG	0.682000										HNSCC(69;0.2)			10	33					0	0	0.000978	0	0
DGAT2	84649	broad.mit.edu	37	11	75509329	75509329	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:75509329C>G	ENST00000228027.7	+	7	1127	c.867C>G	c.(865-867)atC>atG	p.I289M	DGAT2_ENST00000376262.3_Missense_Mutation_p.I246M	NM_032564.4	NP_115953.2	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	289					glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity			endometrium(3)|large_intestine(5)|lung(5)|prostate(2)|skin(2)	17	Ovarian(111;0.103)					AGCAGGTGATCTTCGAGGAGG	0.547000													40	145					0	0	0.002522	0	0
FIG4	9896	broad.mit.edu	37	6	110113863	110113863	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:110113863T>C	ENST00000230124.3	+	21	2579	c.2455T>C	c.(2455-2457)Tca>Cca	p.S819P	FIG4_ENST00000441478.2_Missense_Mutation_p.S542P	NM_014845.5	NP_055660.1	Q92562	FIG4_HUMAN	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	819					cell death	endosome membrane	protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)	32		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		CTCCATTTATTCAAGGTGAGA	0.299000													14	20					0	0	0.003163	0	0
VARS	7407	broad.mit.edu	37	6	31762881	31762881	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31762881G>A	ENST00000375663.3	-	2	554	c.114C>T	c.(112-114)ccC>ccT	p.P38P	VARS_ENST00000444930.2_Intron	NM_006295.2	NP_006286.1	P26640	SYVC_HUMAN	valyl-tRNA synthetase	38					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	30					L-Valine(DB00161)	GACAGATGCGGGGGTGGGCTC	0.721000													64	293					0	0	0.003610	0	0
OR2T1	26696	broad.mit.edu	37	1	248570074	248570074	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:248570074C>T	ENST00000366474.1	+	1	779	c.779C>T	c.(778-780)cCt>cTt	p.P260L		NM_030904.1	NP_112166.1	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T, member 1	260					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(1)|kidney(1)|large_intestine(5)|lung(24)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(1)	39	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGCTGATTCCTTTCTCTGTA	0.507000													18	66					0	0	0.006122	0	0
ANKRD11	29123	broad.mit.edu	37	16	89351405	89351405	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:89351405G>A	ENST00000301030.4	-	9	2005	c.1545C>T	c.(1543-1545)ttC>ttT	p.F515F	ANKRD11_ENST00000378330.2_Silent_p.F515F	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	515	Ser-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		AGAGGGAGCTGAACAGGGAGG	0.647000													18	41					0	0	0.004990	0	0
SMU1	55234	broad.mit.edu	37	9	33048158	33048158	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:33048158G>A	ENST00000397149.3	-	11	1439	c.1389C>T	c.(1387-1389)gaC>gaT	p.D463D	SMU1_ENST00000536631.1_Silent_p.D302D	NM_018225.2	NP_060695.2	Q2TAY7	SMU1_HUMAN	smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)	463						cytoplasm|nucleus				endometrium(2)|lung(4)|ovary(2)|prostate(1)	9			LUSC - Lung squamous cell carcinoma(29;0.0227)	GBM - Glioblastoma multiforme(74;0.11)		AGAGCACAAAGTCCTCCCCTA	0.438000													13	24					0	0	0.001368	0	0
LILRB2	10288	broad.mit.edu	37	19	54784319	54784319	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:54784319G>A	ENST00000391748.1	-	2	160	c.34_splice	c.e2+1	p.L11_splice	LILRB2_ENST00000314446.5_Splice_Site_p.L11_splice|LILRB2_ENST00000391746.1_Splice_Site_p.L11_splice|LILRB2_ENST00000434421.1_5'UTR|LILRB2_ENST00000391749.4_Splice_Site_p.L11_splice	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	11					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		AAATCTCACCGAGACAGATCA	0.597000													33	80					0	0	0.003271	0	0
CCNI	10983	broad.mit.edu	37	4	77977123	77977123	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:77977123G>A	ENST00000237654.4	-	5	1027	c.451C>T	c.(451-453)Ctt>Ttt	p.L151F	CCNI_ENST00000537948.1_Missense_Mutation_p.L137F	NM_006835.2	NP_006826.1	Q14094	CCNI_HUMAN	cyclin I	151					spermatogenesis					NS(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(1)|ovary(1)|prostate(1)	9						ACAATATGAAGAAAATCCAAT	0.318000													27	35					0	0	0.006320	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54917708	54917708	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:54917708C>T	ENST00000293373.6	+	20	2203	c.2124C>T	c.(2122-2124)taC>taT	p.Y708Y	NCKAP1L_ENST00000545638.2_Silent_p.Y658Y	NM_005337.4	NP_005328.2	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	708					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(12)|lung(37)|ovary(3)|prostate(3)|skin(3)|stomach(2)	80						CTTCTGAGTACCTCAGCAGCC	0.448000													34	60					0	0	0.004878	0	0
UBA7	7318	broad.mit.edu	37	3	49851075	49851075	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:49851075A>C	ENST00000333486.3	-	2	220	c.62T>G	c.(61-63)gTg>gGg	p.V21G	UBA7_ENST00000494212.1_5'UTR	NM_003335.2	NP_003326.2	P41226	UBA7_HUMAN	ubiquitin-like modifier activating enzyme 7	21					ISG15-protein conjugation|negative regulation of type I interferon production	cytosol	ATP binding|ISG15 activating enzyme activity|ligase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(15)|large_intestine(4)|lung(7)|ovary(2)|pancreas(1)|upper_aerodigestive_tract(1)	33				BRCA - Breast invasive adenocarcinoma(193;3.58e-06)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TGAGCCCAGCACATACCTGTG	0.602000													8	29					0	0	0.004482	0	0
SIPA1L1	26037	broad.mit.edu	37	14	72176192	72176192	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:72176192C>T	ENST00000555818.1	+	15	4430	c.4082C>T	c.(4081-4083)cCc>cTc	p.P1361L	SIPA1L1_ENST00000537413.1_Missense_Mutation_p.P815L|SIPA1L1_ENST00000358550.2_Missense_Mutation_p.P1340L|SIPA1L1_ENST00000381232.3_Missense_Mutation_p.P1340L|SIPA1L1_ENST00000554874.1_3'UTR	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1361	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		AAAGTGGCACCCCTATGGCAC	0.592000													15	23					0	0	0.003163	0	0
PLCB1	23236	broad.mit.edu	37	20	8678295	8678295	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:8678295C>T	ENST00000378641.3	+	11	1507	c.1032C>T	c.(1030-1032)tcC>tcT	p.S344S	PLCB1_ENST00000378637.2_Silent_p.S344S|PLCB1_ENST00000338037.6_Silent_p.S344S	NM_182734.1	NP_877398.1	Q9NQ66	PLCB1_HUMAN	phospholipase C, beta 1 (phosphoinositide-specific)	344	PI-PLC X-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			NS(2)|breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(11)|liver(2)|lung(41)|ovary(4)|prostate(3)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	95						CTGGAAACTCCTCTGTTGAGA	0.522000													34	135					0	0	0.004289	0	0
LIN7A	8825	broad.mit.edu	37	12	81239577	81239577	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:81239577G>A	ENST00000552864.1	-	4	617	c.415C>T	c.(415-417)Cct>Tct	p.P139S		NM_004664.2	NP_004655.1	O14910	LIN7A_HUMAN	lin-7 homolog A (C. elegans)	139	PDZ.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|ovary(2)|skin(2)	15						ACCCCTCCAGGAATTATGCGA	0.458000													34	67					0	0	0.003755	0	0
STAB2	55576	broad.mit.edu	37	12	104042572	104042572	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:104042572G>A	ENST00000388887.2	+	10	1349	c.1145G>A	c.(1144-1146)gGa>gAa	p.G382E		NM_017564.9	NP_060034.9	Q8WWQ8	STAB2_HUMAN	stabilin 2	382	FAS1 1.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			NS(4)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(15)|kidney(11)|large_intestine(26)|lung(77)|ovary(10)|pancreas(1)|prostate(5)|skin(14)|stomach(2)	174						AAATGGCAAGGAAGGCTGACC	0.443000													37	74					0	0	0.006230	0	0
OR6B1	135946	broad.mit.edu	37	7	143701692	143701692	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:143701692C>T	ENST00000408922.2	+	1	671	c.603C>T	c.(601-603)atC>atT	p.I201I		NM_001005281.1	NP_001005281.1	O95007	OR6B1_HUMAN	olfactory receptor, family 6, subfamily B, member 1	201					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(3)|large_intestine(3)|lung(15)|ovary(2)|skin(2)|urinary_tract(1)	27	Melanoma(164;0.0783)					TAGACTTTATCCTGGCACTGG	0.458000													37	45					0	0	0.006999	0	0
CPT1A	1374	broad.mit.edu	37	11	68529011	68529011	+	Missense_Mutation	SNP	G	G	A	rs75908421		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:68529011G>A	ENST00000265641.5	-	16	2174	c.2020C>T	c.(2020-2022)Ctt>Ttt	p.L674F	CPT1A_ENST00000376618.2_Missense_Mutation_p.L674F|CPT1A_ENST00000539743.1_Missense_Mutation_p.L674F|CPT1A_ENST00000540367.1_Missense_Mutation_p.L674F	NM_001876.3	NP_001867.2	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A (liver)	674					carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			NS(2)|breast(1)|endometrium(2)|kidney(1)|large_intestine(7)|liver(1)|lung(17)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	ACTTCCTTAAGGAAAGGGGAC	0.448000													94	46					0	0	0.003610	0	0
KBTBD12	166348	broad.mit.edu	37	3	127642587	127642587	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:127642587C>T	ENST00000405109.1	+	2	1150	c.683C>T	c.(682-684)tCt>tTt	p.S228F	KBTBD12_ENST00000405256.1_Missense_Mutation_p.S228F|KBTBD12_ENST00000407609.3_Intron|KBTBD12_ENST00000343941.4_Intron			Q3ZCT8	KBTBC_HUMAN	kelch repeat and BTB (POZ) domain containing 12	228	BACK.									endometrium(1)|large_intestine(6)|lung(5)|ovary(1)	13						GTAAATCCTTCTTTTTTAAGA	0.383000													22	45					0	0	0.001523	0	0
PTCHD3P1	387647	broad.mit.edu	37	10	29710357	29710357	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:29710357C>T	ENST00000427063.2	+	0	1081				PTCHD3P1_ENST00000455774.1_RNA|PTCHD3P1_ENST00000430295.1_RNA|PTCHD3P1_ENST00000445521.1_RNA|PTCHD3P1_ENST00000414457.1_RNA|PTCHD3P1_ENST00000537908.1_RNA|PTCHD3P1_ENST00000446807.1_RNA|PTCHD3P1_ENST00000423223.1_RNA|PTCHD3P1_ENST00000438202.1_RNA|PTCHD3P1_ENST00000413405.1_RNA	NR_003930.1																						AAATCTTCCTCGTCCCTCCCA	0.483000													16	16					0	0	0.001216	0	0
PDE6C	5146	broad.mit.edu	37	10	95372854	95372854	+	Silent	SNP	G	G	A	rs147367341		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:95372854G>A	ENST00000371447.3	+	1	510	c.372G>A	c.(370-372)gaG>gaA	p.E124E		NM_006204.3	NP_006195.3	P51160	PDE6C_HUMAN	phosphodiesterase 6C, cGMP-specific, cone, alpha prime	124	GAF 1.				visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(12)|ovary(2)|pancreas(1)|skin(4)|upper_aerodigestive_tract(1)	42		Colorectal(252;0.123)				CCAAGTTTGAGGACAACCTGG	0.552000													20	26					0	0	0.001216	0	0
CASR	846	broad.mit.edu	37	3	121973120	121973120	+	Missense_Mutation	SNP	G	G	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:121973120G>C	ENST00000498619.1	+	2	522	c.84G>C	c.(82-84)aaG>aaC	p.K28N	CASR_ENST00000490131.1_Missense_Mutation_p.K28N|CASR_ENST00000296154.5_Missense_Mutation_p.K28N	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	28					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GAGCCCAAAAGAAGGGGGACA	0.522000													37	74					0	0	0.003271	0	0
MACF1	23499	broad.mit.edu	37	1	39800079	39800079	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:39800079G>A	ENST00000564288.1	+	37	8596	c.7819G>A	c.(7819-7821)Gaa>Aaa	p.E2607K	MACF1_ENST00000361689.2_Intron|MACF1_ENST00000476350.1_Intron|MACF1_ENST00000539005.1_Intron|MACF1_ENST00000545844.1_Intron|MACF1_ENST00000567887.1_Missense_Mutation_p.E2644K|MACF1_ENST00000372915.3_Missense_Mutation_p.E2612K|MACF1_ENST00000317713.7_Intron|MACF1_ENST00000289893.4_Missense_Mutation_p.E1047K			Q9UPN3	MACF1_HUMAN	microtubule-actin crosslinking factor 1	2612					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			breast(11)|central_nervous_system(5)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(36)|lung(78)|ovary(12)|prostate(2)|skin(9)|stomach(2)|upper_aerodigestive_tract(8)|urinary_tract(10)	203	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GTTAACTAATGAAGCAGTATT	0.408000													26	42					0	0	0.003330	0	0
CYP7A1	1581	broad.mit.edu	37	8	59409365	59409365	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:59409365C>T	ENST00000301645.3	-	3	843	c.706G>A	c.(706-708)Gag>Aag	p.E236K		NM_000780.3	NP_000771.2	P22680	CP7A1_HUMAN	cytochrome P450, family 7, subfamily A, polypeptide 1	236					bile acid biosynthetic process|cellular lipid metabolic process|cellular response to cholesterol|cellular response to glucose stimulus|cholesterol catabolic process|cholesterol homeostasis|regulation of bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholesterol 7-alpha-monooxygenase activity|electron carrier activity|heme binding			breast(4)|endometrium(1)|kidney(2)|large_intestine(5)|lung(19)|ovary(1)|prostate(1)|urinary_tract(1)	34		all_lung(136;0.0271)|Lung NSC(129;0.0351)|all_epithelial(80;0.0554)				GCCAGTTTCTCCCGGGCATTG	0.498000									Neonatal Giant Cell Hepatitis				42	224					0	0	0.001951	0	0
EP300	2033	broad.mit.edu	37	22	41573345	41573345	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:41573345C>T	ENST00000263253.7	+	31	6849	c.5630C>T	c.(5629-5631)cCt>cTt	p.P1877L	RP1-85F18.6_ENST00000415054.1_RNA|RP1-85F18.5_ENST00000420537.1_RNA	NM_001429.3	NP_001420.2	Q09472	EP300_HUMAN	E1A binding protein p300	1877					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			NS(2)|breast(11)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(31)|kidney(5)|large_intestine(31)|liver(2)|lung(33)|ovary(2)|pancreas(4)|prostate(1)|skin(6)|stomach(1)|upper_aerodigestive_tract(8)|urinary_tract(16)	171						CAGCCTCAGCCTACCCCTCCC	0.647000			"""T,  N, F, Mis, O"""	"""MLL, RUNXBP2"""	"""colorectal, breast, pancreatic, AML, ALL, DLBCL"""				Rubinstein-Taybi syndrome				15	125					0	0	0.004007	0	0
OSBPL3	26031	broad.mit.edu	37	7	24902884	24902884	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:24902884C>T	ENST00000313367.2	-	9	1256	c.805G>A	c.(805-807)Gaa>Aaa	p.E269K	OSBPL3_ENST00000409069.1_Intron|OSBPL3_ENST00000431825.2_Intron|OSBPL3_ENST00000396431.1_Intron|OSBPL3_ENST00000352860.1_Intron|OSBPL3_ENST00000396429.1_Missense_Mutation_p.E269K|OSBPL3_ENST00000353930.1_Missense_Mutation_p.E269K	NM_015550.2	NP_056365.1	Q9H4L5	OSBL3_HUMAN	oxysterol binding protein-like 3	269					lipid transport		lipid binding|protein binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(10)|lung(19)|prostate(1)|skin(3)|urinary_tract(1)	43						GATCTTTTTTCCTTTTTGGGA	0.448000													16	19					0	0	0.006122	0	0
FAM129A	116496	broad.mit.edu	37	1	184787892	184787892	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:184787892C>T	ENST00000367511.3	-	9	1246	c.1053G>A	c.(1051-1053)ctG>ctA	p.L351L	FAM129A_ENST00000487074.1_5'UTR	NM_052966.2	NP_443198.1	Q9BZQ8	NIBAN_HUMAN	family with sequence similarity 129, member A	351					negative regulation of protein phosphorylation|positive regulation of protein phosphorylation|positive regulation of translation|response to endoplasmic reticulum stress	cytoplasm|nucleus|plasma membrane				autonomic_ganglia(1)|breast(1)|cervix(2)|endometrium(4)|large_intestine(6)|liver(1)|lung(22)|ovary(3)|skin(3)|upper_aerodigestive_tract(2)	45						TGAGCTCCTCCAGGATGGATG	0.527000													53	207					0	0	0.003610	0	0
SLC38A8	146167	broad.mit.edu	37	16	84063101	84063101	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:84063101G>A	ENST00000299709.3	-	5	687	c.688C>T	c.(688-690)Cag>Tag	p.Q230*		NM_001080442.1	NP_001073911.1	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	230					amino acid transport|sodium ion transport	integral to membrane				central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	26						AAAATTACCTGAAACCCGAAG	0.522000													7	29					0	0	0.001984	0	0
CACNA1B	774	broad.mit.edu	37	9	141012397	141012397	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:141012397G>A	ENST00000277549.5	+	43	5928		c.e43-1		CACNA1B_ENST00000371372.1_Splice_Site|CACNA1B_ENST00000277551.2_Splice_Site|CACNA1B_ENST00000371355.4_Splice_Site|CACNA1B_ENST00000371363.1_Splice_Site|CACNA1B_ENST00000371357.1_Splice_Site			Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit						membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CTCTGCCACAGACAAAACCAA	0.567000													12	0					0	0	0.002450	0	0
HNRNPA1L2	144983	broad.mit.edu	37	13	53217246	53217246	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:53217246G>A	ENST00000342657.3	+	7	1692	c.619G>A	c.(619-621)Gga>Aga	p.G207R	HNRNPA1L2_ENST00000357495.2_Missense_Mutation_p.G207R|HNRNPA1L2_ENST00000398039.1_Missense_Mutation_p.G207R	NM_001011724.1	NP_001011724.1	Q32P51	RA1L2_HUMAN	heterogeneous nuclear ribonucleoprotein A1-like 2	207	Gly-rich.				mRNA processing|mRNA transport|RNA splicing	cytoplasm|spliceosomal complex	nucleotide binding|RNA binding			cervix(1)|large_intestine(1)|lung(5)	7						tggtggtcgtggagatggttt	0.527000													11	19					0	0	0.001368	0	0
DMBT1	1755	broad.mit.edu	37	10	124352006	124352006	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:124352006G>A	ENST00000368909.3	+	20	2501	c.2395G>A	c.(2395-2397)Gat>Aat	p.D799N	DMBT1_ENST00000359586.6_Intron|DMBT1_ENST00000330163.4_Intron|DMBT1_ENST00000368955.3_Missense_Mutation_p.D789N|DMBT1_ENST00000338354.3_Missense_Mutation_p.D799N|DMBT1_ENST00000368956.2_Intron|DMBT1_ENST00000344338.3_Missense_Mutation_p.D789N	NM_007329.2	NP_015568.2	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	799	SRCR 6.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				TGTTCTGGATGATGTGCGCTG	0.607000													47	55					0	0	0.003214	0	0
GABRB2	2561	broad.mit.edu	37	5	160721399	160721399	+	Missense_Mutation	SNP	C	C	T	rs148772321		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:160721399C>T	ENST00000274547.2	-	11	1445	c.1228G>A	c.(1228-1230)Gag>Aag	p.E410K	GABRB2_ENST00000520240.1_Missense_Mutation_p.E372K|GABRB2_ENST00000517547.1_Missense_Mutation_p.E212K|GABRB2_ENST00000353437.6_Missense_Mutation_p.E372K|GABRB2_ENST00000393959.1_Missense_Mutation_p.E410K|GABRB2_ENST00000517901.1_Missense_Mutation_p.E309K	NM_000813.2|NM_021911.2	NP_000804.1|NP_068711.1	P47870	GBRB2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta 2	410					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|GABA-A receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TTTTTTATCTCGAGAGTGCTC	0.463000													44	74					0	0	0.003610	0	0
ZNF91	7644	broad.mit.edu	37	19	23542432	23542432	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:23542432C>T	ENST00000300619.7	-	4	3554	c.3349G>A	c.(3349-3351)Gag>Aag	p.E1117K	ZNF91_ENST00000599743.1_Intron|ZNF91_ENST00000397082.2_Missense_Mutation_p.E1085K	NM_003430.2	NP_003421.2	Q05481	ZNF91_HUMAN	zinc finger protein 91	1117						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.E1117Q(1)					all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GCTGAGGACTCTTTAAAGGCT	0.408000													15	19					0	0	0.003163	0	0
ZC3H7B	23264	broad.mit.edu	37	22	41735933	41735933	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:41735933C>T	ENST00000352645.4	+	10	1187	c.930C>T	c.(928-930)atC>atT	p.I310I	ZC3H7B_ENST00000351589.4_Silent_p.I310I	NM_017590.4	NP_060060.3	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	326					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(4)|lung(11)|ovary(3)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(3)	38						GTGGCTCCATCCCTGTCTCCA	0.687000													17	51					0	0	0.004990	0	0
COBL	23242	broad.mit.edu	37	7	51092834	51092834	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:51092834G>A	ENST00000395542.2	-	14	4170	c.3986C>T	c.(3985-3987)tCc>tTc	p.S1329F	COBL_ENST00000265136.7_Missense_Mutation_p.S1247F			O75128	COBL_HUMAN	cordon-bleu WH2 repeat protein	1247										NS(2)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(10)|lung(26)|ovary(3)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	65	Glioma(55;0.08)					CCCTGTGCCGGAGCGGATGGC	0.627000													30	78					0	0	0.001786	0	0
ABT1	29777	broad.mit.edu	37	6	26598510	26598510	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:26598510C>T	ENST00000274849.1	+	3	487	c.456C>T	c.(454-456)acC>acT	p.T152T		NM_013375.3	NP_037507.1	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	152					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(1)|urinary_tract(1)	11						ACCGTTTCACCTGGTCCCACC	0.557000													30	177					0	0	0.005524	0	0
UNC5C	8633	broad.mit.edu	37	4	96106278	96106278	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:96106278C>T	ENST00000453304.1	-	13	2554	c.2206G>A	c.(2206-2208)Ggc>Agc	p.G736S		NM_003728.3	NP_003719.3	O95185	UNC5C_HUMAN	unc-5 homolog C (C. elegans)	736					apoptosis|axon guidance|brain development	integral to membrane	netrin receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(14)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	55		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;8.72e-10)		TGGGTGCTGCCTTTAAAATGA	0.473000													26	44					0	0	0.005443	0	0
SCN10A	6336	broad.mit.edu	37	3	38765044	38765044	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:38765044C>T	ENST00000449082.2	-	18	3228	c.3228_splice	c.e18-1	p.G1077_splice		NM_006514.2	NP_006505.2	Q9Y5Y9	SCNAA_HUMAN	sodium channel, voltage-gated, type X, alpha subunit	1077					sensory perception	voltage-gated sodium channel complex				NS(5)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(14)|kidney(5)|large_intestine(33)|lung(54)|ovary(5)|pancreas(1)|prostate(5)|skin(13)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	150				KIRC - Kidney renal clear cell carcinoma(284;0.0769)|Kidney(284;0.0945)	Benzocaine(DB01086)|Bupivacaine(DB00297)|Chloroprocaine(DB01161)|Cocaine(DB00907)|Dibucaine(DB00527)|Dyclonine(DB00645)|Hexylcaine(DB00473)|Levobupivacaine(DB01002)|Lidocaine(DB00281)|Mepivacaine(DB00961)|Oxybuprocaine(DB00892)|Procaine(DB00721)|Proparacaine(DB00807)|Ropivacaine(DB00296)	TCGTCCACTCCCTGCAGGGGA	0.602000													4	2					0	0	0.000602	0	0
ARHGEF28	64283	broad.mit.edu	37	5	73045673	73045673	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:73045673G>A	ENST00000545377.1	+	3	221	c.45G>A	c.(43-45)atG>atA	p.M15I	ARHGEF28_ENST00000287898.5_Missense_Mutation_p.M15I|ARHGEF28_ENST00000296794.6_Missense_Mutation_p.M15I|ARHGEF28_ENST00000513042.2_Missense_Mutation_p.M15I|ARHGEF28_ENST00000437974.1_Missense_Mutation_p.M15I|ARHGEF28_ENST00000426542.2_Missense_Mutation_p.M15I	NM_001080479.2	NP_001073948.2			Rho guanine nucleotide exchange factor (GEF) 28																		GGCAGATGATGATCTATGCGA	0.433000													20	82					0	0	0.001882	0	0
OR5M10	390167	broad.mit.edu	37	11	56345099	56345099	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:56345099C>T	ENST00000526812.2	-	1	164	c.99G>A	c.(97-99)gcG>gcA	p.A33A		NM_001004741.1	NP_001004741.1	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M, member 10	33					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(2)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(2)	25						TTAGGTAGATCGCCAGGAACA	0.488000													106	372					0	0	0.003610	0	0
PDIA4	9601	broad.mit.edu	37	7	148701261	148701261	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:148701261C>T	ENST00000286091.4	-	10	1795	c.1563G>A	c.(1561-1563)aaG>aaA	p.K521K		NM_004911.4	NP_004902.1	P13667	PDIA4_HUMAN	protein disulfide isomerase family A, member 4	521	Thioredoxin 3.				cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			large_intestine(6)|lung(15)|ovary(2)|prostate(1)	24	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			CCTTGTTGTTCTTGGGCACTG	0.557000													43	79					0	0	0.003610	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20585984	20585984	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:20585984C>T	ENST00000202677.6	-	15	2015	c.1873G>A	c.(1873-1875)Ggt>Agt	p.G625S	RALGAPA2_ENST00000495793.1_5'UTR	NM_020343.3	NP_065076.2	Q2PPJ7	RGPA2_HUMAN	Ral GTPase activating protein, alpha subunit 2 (catalytic)	625					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|liver(1)|lung(25)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	54						GACAGCACACCAAGAAAGTCA	0.478000													10	54					0	0	0.006214	0	0
RBM47	54502	broad.mit.edu	37	4	40434799	40434799	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:40434799G>A	ENST00000319592.4	-	5	1913	c.1204C>T	c.(1204-1206)Cac>Tac	p.H402Y	RBM47_ENST00000514014.1_Missense_Mutation_p.H433Y|RBM47_ENST00000515809.1_5'UTR|RBM47_ENST00000381793.2_Missense_Mutation_p.H471Y|RBM47_ENST00000295971.7_Missense_Mutation_p.H471Y|RBM47_ENST00000381795.6_Missense_Mutation_p.H402Y			A0AV96	RBM47_HUMAN	RNA binding motif protein 47	417						nucleus	nucleotide binding|RNA binding			breast(5)|endometrium(1)|kidney(3)|large_intestine(2)|lung(9)|ovary(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)	29						TCCACTGTGTGGATTTTGCCA	0.592000													15	76					0	0	0.003163	0	0
ADAM30	11085	broad.mit.edu	37	1	120437893	120437893	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:120437893C>T	ENST00000369400.1	-	1	1225	c.1067G>A	c.(1066-1068)aGg>aAg	p.R356K		NM_021794.3	NP_068566.2	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30	356	Peptidase M12B.				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(11)|lung(16)|ovary(2)|skin(2)	38	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		AAGCCTACCCCTACATTGGCA	0.433000													207	535					0	0	0.003610	0	0
DOCK7	85440	broad.mit.edu	37	1	62993884	62993884	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:62993884C>G	ENST00000251157.5	-	31	3907	c.3874G>C	c.(3874-3876)Gca>Cca	p.A1292P	DOCK7_ENST00000340370.5_Missense_Mutation_p.A1261P	NM_001271999.1	NP_001258928.1	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1292					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(8)|kidney(6)|large_intestine(19)|lung(42)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	92						CCTGCGATTGCCATGGCAACG	0.433000													17	30					0	0	0.004990	0	0
ROBO2	6092	broad.mit.edu	37	3	77595509	77595509	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:77595509C>T	ENST00000461745.1	+	7	1855	c.955C>T	c.(955-957)Cgg>Tgg	p.R319W	ROBO2_ENST00000332191.8_Missense_Mutation_p.R319W|ROBO2_ENST00000487694.3_Missense_Mutation_p.R335W	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	319	Ig-like C2-type 4.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GTTTGTGGTTCGGCCAAGAGA	0.393000													57	135					0	0	0.003610	0	0
PLD2	5338	broad.mit.edu	37	17	4722875	4722875	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:4722875C>T	ENST00000263088.6	+	23	2591	c.2460C>T	c.(2458-2460)ttC>ttT	p.F820F	PLD2_ENST00000572940.1_Intron	NM_001243108.1|NM_002663.4	NP_001230037.1|NP_002654.3	O14939	PLD2_HUMAN	phospholipase D2	820					cell communication|cytoskeleton organization|small GTPase mediated signal transduction		NAPE-specific phospholipase D activity|phosphatidylinositol binding|phospholipase D activity			autonomic_ganglia(1)|breast(4)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(3)|lung(10)|ovary(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)	31					Choline(DB00122)	AGCACTGCTTCGGGTAGAGCT	0.617000													15	15					0	0	0.003163	0	0
DST	667	broad.mit.edu	37	6	56482908	56482908	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:56482908G>A	ENST00000370765.6	-	23	6031	c.5924C>T	c.(5923-5925)cCc>cTc	p.P1975L	DST_ENST00000312431.6_Intron|DST_ENST00000370754.5_Intron|DST_ENST00000244364.6_Intron|DST_ENST00000446842.2_Intron|DST_ENST00000370769.4_Intron|DST_ENST00000421834.2_Intron|DST_ENST00000370788.2_Intron|DST_ENST00000361203.3_Intron	NM_001723.5	NP_001714.1	Q03001	DYST_HUMAN	dystonin	1374					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TCTTGTAATGGGGTTTGTCTC	0.433000													23	122					0	0	0.002299	0	0
GRPEL2	134266	broad.mit.edu	37	5	148727858	148727858	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:148727858C>T	ENST00000329271.3	+	2	211	c.101C>T	c.(100-102)aCt>aTt	p.T34I	GRPEL2_ENST00000513661.1_Missense_Mutation_p.T34I|RP11-394O4.4_ENST00000521295.1_RNA|GRPEL2_ENST00000416916.2_Missense_Mutation_p.T34I|GRPEL2_ENST00000507562.1_3'UTR	NM_152407.3	NP_689620.2	Q8TAA5	GRPE2_HUMAN	GrpE-like 2, mitochondrial (E. coli)	34					protein folding	mitochondrial matrix	adenyl-nucleotide exchange factor activity|chaperone binding|protein homodimerization activity			breast(1)|endometrium(1)|large_intestine(1)|lung(2)|ovary(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCATTCAGCACTGCCACCCAG	0.507000													57	73					0	0	0.003610	0	0
GPR4	2828	broad.mit.edu	37	19	46094512	46094512	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:46094512G>A	ENST00000323040.4	-	2	1557	c.613C>T	c.(613-615)Ctg>Ttg	p.L205L	OPA3_ENST00000544371.1_Intron	NM_005282.2	NP_005273.1	P46093	GPR4_HUMAN	G protein-coupled receptor 4	205						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|kidney(3)|large_intestine(1)|lung(11)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		ACGGCCCGCAGGATGCCCCGG	0.657000													13	30					0	0	0.001855	0	0
SNRPB	6628	broad.mit.edu	37	20	2442428	2442428	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:2442428G>A	ENST00000438552.2	-	7	859	c.697C>T	c.(697-699)Ccg>Tcg	p.P233S	SNRPB_ENST00000381342.2_3'UTR	NM_198216.1	NP_937859.1	P14678	RSMB_HUMAN	small nuclear ribonucleoprotein polypeptides B and B1	233	Repeat-rich region.				histone mRNA metabolic process|ncRNA metabolic process|spliceosomal snRNP assembly|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|cytosol|nucleoplasm|U12-type spliceosomal complex|U7 snRNP	protein binding|RNA binding			kidney(1)|large_intestine(2)|lung(4)|ovary(1)|skin(1)|urinary_tract(1)	10						CGCATTCCCGGGGGAGGGGGC	0.552000													17	83					0	0	0.006122	0	0
PCLO	27445	broad.mit.edu	37	7	82544134	82544134	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:82544134C>T	ENST00000423517.2	-	7	13505	c.13168G>A	c.(13168-13170)Gat>Aat	p.D4390N	PCLO_ENST00000437081.1_Missense_Mutation_p.D1110N|PCLO_ENST00000333891.8_Missense_Mutation_p.D4390N	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	4321					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CCAAACTGATCCCTGGTGTCT	0.522000													18	18					0	0	0.006122	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27999123	27999123	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:27999123T>A	ENST00000441525.1	-	1	443	c.329A>T	c.(328-330)gAa>gTa	p.E110V		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	110	Glu-rich.									NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						ctcctccccttcctcctccat	0.517000													21	3					0	0	0.001216	0	0
AMER1	139285	broad.mit.edu	37	X	63410327	63410327	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:63410327G>A	ENST00000330258.3	-	2	3112	c.2840C>T	c.(2839-2841)tCc>tTc	p.S947F	AMER1_ENST00000403336.1_Intron|AMER1_ENST00000374869.3_Intron	NM_152424.3	NP_689637.3			APC membrane recruitment protein 1									p.0?(67)									AGTATAGAGGGAAAGGGGACT	0.587000													6	1					0	0	0.001984	0	0
SCYL2	55681	broad.mit.edu	37	12	100720500	100720500	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:100720500C>T	ENST00000360820.2	+	12	2047	c.1610C>T	c.(1609-1611)tCc>tTc	p.S537F		NM_017988.4	NP_060458.3	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 (S. cerevisiae)	537					endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(12)|large_intestine(4)|lung(15)|ovary(2)|skin(1)	41						CAAATTCCATCCAAGGAACCT	0.333000													18	37					0	0	0.007413	0	0
PLA2G4E	123745	broad.mit.edu	37	15	42276730	42276730	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:42276730C>T	ENST00000399518.3	-	19	2776	c.2290G>A	c.(2290-2292)Gaa>Aaa	p.E764K	PLA2G4E_ENST00000413860.2_Missense_Mutation_p.E735K|CTD-2382E5.1_ENST00000499478.2_RNA	NM_001206670.1	NP_001193599.1	Q3MJ16	PA24E_HUMAN	phospholipase A2, group IVE	752	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(4)|lung(2)|ovary(1)|prostate(1)|stomach(1)	16		all_cancers(109;8.09e-13)|all_epithelial(112;2.03e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.0273)		OV - Ovarian serous cystadenocarcinoma(18;7.61e-18)|GBM - Glioblastoma multiforme(94;3.07e-06)		AGGTAGCATTCCTTGAGATTT	0.502000													12	21					0	0	0.002450	0	0
DNER	92737	broad.mit.edu	37	2	230453181	230453181	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:230453181C>T	ENST00000341772.4	-	3	743	c.609G>A	c.(607-609)ggG>ggA	p.G203G		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	203					central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		AACTGGCATTCCCACAGGCAA	0.413000													13	28					0	0	0.003163	0	0
KIAA1549L	25758	broad.mit.edu	37	11	33564018	33564018	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:33564018C>T	ENST00000321505.4	+	1	198	c.18C>T	c.(16-18)tcC>tcT	p.S6S	KIAA1549L_ENST00000389726.3_Silent_p.S6S|KIAA1549L_ENST00000265654.5_Silent_p.S6S					KIAA1549-like																		ACACTGCATCCCAAAATGCCC	0.493000													7	30					0	0	0.001984	0	0
IARS	3376	broad.mit.edu	37	9	95004508	95004508	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:95004508G>A	ENST00000375643.3	-	29	3371	c.3105C>T	c.(3103-3105)acC>acT	p.T1035T	IARS_ENST00000443024.2_Silent_p.T1035T|IARS_ENST00000375629.3_Silent_p.T88T|IARS_ENST00000474340.1_5'UTR|IARS_ENST00000447699.2_Silent_p.T925T|IARS_ENST00000375627.1_Silent_p.T88T	NM_013417.2	NP_038203.2	P41252	SYIC_HUMAN	isoleucyl-tRNA synthetase	1035					isoleucyl-tRNA aminoacylation	cytosol|nucleus|soluble fraction	ATP binding|isoleucine-tRNA ligase activity|protein binding			breast(3)|endometrium(2)|kidney(4)|large_intestine(7)|lung(14)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	35					L-Isoleucine(DB00167)	CCTTTATGGTGGTAAATATGA	0.383000													21	31					0	0	0.001523	0	0
GCM2	9247	broad.mit.edu	37	6	10874655	10874655	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:10874655G>A	ENST00000379491.4	-	5	1241	c.1094C>T	c.(1093-1095)cCc>cTc	p.P365L	SYCP2L_ENST00000543878.1_Intron|RP11-637O19.3_ENST00000480294.1_Intron	NM_004752.3	NP_004743.1	O75603	GCM2_HUMAN	glial cells missing homolog 2 (Drosophila)	365					cellular calcium ion homeostasis|cellular phosphate ion homeostasis|parathyroid gland development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|sequence-specific DNA binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(8)|ovary(2)|prostate(2)|upper_aerodigestive_tract(2)	30	Breast(50;0.0838)|Ovarian(93;0.107)	all_hematologic(90;0.135)				GTACCTGCAGGGAAGCTCTGG	0.572000													45	276					0	0	0.003610	0	0
KNG1	3827	broad.mit.edu	37	3	186459557	186459557	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:186459557G>A	ENST00000265023.4	+	10	1584	c.1372G>A	c.(1372-1374)Gga>Aga	p.G458R	RP11-573D15.8_ENST00000354642.2_RNA|KNG1_ENST00000287611.2_Intron|KNG1_ENST00000447445.1_Intron|RP11-573D15.8_ENST00000599314.1_RNA	NM_001102416.2	NP_001095886.1	P01042	KNG1_HUMAN	kininogen 1	458	His-rich.				blood coagulation, intrinsic pathway|elevation of cytosolic calcium ion concentration|inflammatory response|negative regulation of blood coagulation|negative regulation of cell adhesion|platelet activation|platelet degranulation|positive regulation of apoptosis|positive regulation of renal sodium excretion|positive regulation of urine volume|smooth muscle contraction|vasodilation	extracellular space|plasma membrane|platelet alpha granule lumen	cysteine-type endopeptidase inhibitor activity|heparin binding|receptor binding|zinc ion binding			endometrium(1)|lung(15)|prostate(1)|skin(2)|stomach(2)	21	all_cancers(143;8.96e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;4.12e-20)	GBM - Glioblastoma multiforme(93;0.0798)	Ouabain(DB01092)	GCACCAAAGAGGACATGGCCT	0.478000													11	24					0	0	0.001368	0	0
VPS33A	65082	broad.mit.edu	37	12	122750878	122750878	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:122750878G>A	ENST00000267199.4	-	1	190	c.78C>T	c.(76-78)ttC>ttT	p.F26F	VPS33A_ENST00000451053.2_Silent_p.F26F|RP11-512M8.5_ENST00000535844.1_Silent_p.F26F	NM_022916.4	NP_075067.2	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33 homolog A (S. cerevisiae)	26					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(4)|lung(13)|ovary(1)|skin(2)	28	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		ACTTGTCCAGGAACTCGCGCA	0.672000													12	30					0	0	0.004007	0	0
MTMR11	10903	broad.mit.edu	37	1	149906993	149906993	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:149906993G>A	ENST00000439741.2	-	5	604	c.354C>T	c.(352-354)ctC>ctT	p.L118L	MTMR11_ENST00000369140.3_Silent_p.L46L|MTMR11_ENST00000492824.1_5'UTR|MTMR11_ENST00000406732.3_Silent_p.L90L|MTMR11_ENST00000361405.6_Silent_p.L118L	NM_001145862.1	NP_001139334.1	A4FU01	MTMRB_HUMAN	myotubularin related protein 11	118							phosphatase activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(3)|lung(13)|prostate(2)|stomach(1)|urinary_tract(4)	34	Breast(34;0.0009)|Ovarian(49;0.0377)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.221)|STAD - Stomach adenocarcinoma(528;0.247)			ACCCTGGACGGAGGAGCTGGA	0.547000													21	42					0	0	0.003330	0	0
MEP1A	4224	broad.mit.edu	37	6	46787321	46787321	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:46787321G>A	ENST00000230588.4	+	7	445	c.436G>A	c.(436-438)Gga>Aga	p.G146R		NM_005588.2	NP_005579.2	Q16819	MEP1A_HUMAN	meprin A, alpha (PABA peptide hydrolase)	146	Metalloprotease.				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(1)|endometrium(5)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	42			Lung(136;0.192)			CATTGGCCAAGGATGTGCCTA	0.443000													35	134					0	0	0.002445	0	0
DLGAP4	22839	broad.mit.edu	37	20	35060160	35060160	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:35060160G>A	ENST00000373913.3	+	3	520	c.40G>A	c.(40-42)Gac>Aac	p.D14N	DLGAP4_ENST00000339266.5_Missense_Mutation_p.D14N|DLGAP4_ENST00000401952.2_Missense_Mutation_p.D14N|DLGAP4_ENST00000373907.2_Missense_Mutation_p.D14N			Q9Y2H0	DLGP4_HUMAN	discs, large (Drosophila) homolog-associated protein 4	14					cell-cell signaling	membrane	protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(2)|large_intestine(3)|lung(20)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	37	Breast(12;0.0192)	Myeloproliferative disorder(115;0.00878)				CCACCTCTCCGACAGCCTAGA	0.726000													9	33					0	0	0.004482	0	0
DPYD	1806	broad.mit.edu	37	1	97981388	97981388	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:97981388G>A	ENST00000370192.3	-	13	1734	c.1634C>T	c.(1633-1635)cCt>cTt	p.P545L		NM_000110.3	NP_000101.2	Q12882	DPYD_HUMAN	dihydropyrimidine dehydrogenase	545					'de novo' pyrimidine base biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|UMP biosynthetic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|NADP binding|protein homodimerization activity	p.P545H(1)		NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	AAGACCAAAAGGATTTATAAA	0.458000													24	24					0	0	0.003954	0	0
OR6Q1	219952	broad.mit.edu	37	11	57799105	57799105	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57799105G>A	ENST00000302622.3	+	1	704	c.681G>A	c.(679-681)tgG>tgA	p.W227*	OR9Q1_ENST00000335397.3_Intron	NM_001005186.2	NP_001005186.2	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q, member 1	227					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			biliary_tract(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(21;0.0707)|all_epithelial(135;0.142)				ACATCGTCTGGACACTGCTGC	0.542000													53	53					0	0	0.003610	0	0
ADH1C	126	broad.mit.edu	37	4	100268182	100268182	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:100268182C>T	ENST00000510055.1	-	0	414				ADH1C_ENST00000515683.1_RNA			P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	CTGTAGTCACCCCTTCTCAAA	0.517000													55	88					0	0	0.003610	0	0
CD2AP	23607	broad.mit.edu	37	6	47576991	47576991	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:47576991C>T	ENST00000359314.5	+	16	2221	c.1765C>T	c.(1765-1767)Cag>Tag	p.Q589*	CD2AP_ENST00000486693.1_3'UTR	NM_012120.2	NP_036252.1	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	589					cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	20			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			ACTTAGAGCCCAGATTATTGA	0.378000													27	123					0	0	0.006320	0	0
SLC35D3	340146	broad.mit.edu	37	6	137245365	137245365	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:137245365T>G	ENST00000331858.4	+	2	947	c.782T>G	c.(781-783)gTg>gGg	p.V261G		NM_001008783.1	NP_001008783.1	Q5M8T2	S35D3_HUMAN	solute carrier family 35, member D3	261					carbohydrate transport	integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)	13	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000136)|OV - Ovarian serous cystadenocarcinoma(155;0.00365)		GTGGGTGTGGTGAAGAGCATC	0.607000													5	16					0	0	0.000602	0	0
NEGR1	257194	broad.mit.edu	37	1	71873147	71873147	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:71873147C>A	ENST00000357731.4	-	7	1286	c.1047G>T	c.(1045-1047)aaG>aaT	p.K349N	ZRANB2-AS2_ENST00000430605.1_RNA|NEGR1_ENST00000434200.1_Missense_Mutation_p.K303N|NEGR1_ENST00000306821.3_Missense_Mutation_p.K221N	NM_173808.2	NP_776169.2	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1	349					cell adhesion	anchored to membrane|plasma membrane				endometrium(1)|kidney(4)|large_intestine(7)|lung(16)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		GAATGGCATTCTTCAGGTAGA	0.428000													12	17					5.50884e-06	9.35575e-06	0.001368	1	0
DST	667	broad.mit.edu	37	6	56335074	56335074	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:56335074G>A	ENST00000370754.5	-	96	22234	c.22235C>T	c.(22234-22236)cCa>cTa	p.P7412L	DST_ENST00000312431.6_3'UTR|DST_ENST00000244364.6_Missense_Mutation_p.P4820L|DST_ENST00000446842.2_Missense_Mutation_p.P6908L|DST_ENST00000370769.4_Missense_Mutation_p.P7234L|DST_ENST00000421834.2_Missense_Mutation_p.P5119L|DST_ENST00000370788.2_Missense_Mutation_p.P5037L|DST_ENST00000361203.3_Missense_Mutation_p.P7123L			Q03001	DYST_HUMAN	dystonin	7232					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			NS(1)|breast(5)|central_nervous_system(8)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(43)|ovary(7)|prostate(1)|skin(4)|upper_aerodigestive_tract(3)	105	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			GCGACTGGTTGGAAACTCTAA	0.388000													5	29					0	0	0.001168	0	0
SCN1A	6323	broad.mit.edu	37	2	166848354	166848354	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:166848354C>T	ENST00000423058.2	-	26	5448	c.5431G>A	c.(5431-5433)Gtt>Att	p.V1811I	SCN1A_ENST00000409050.1_Missense_Mutation_p.V1783I|SCN1A_ENST00000375405.3_Missense_Mutation_p.V1800I|SCN1A_ENST00000303395.4_Missense_Mutation_p.V1811I|AC010127.3_ENST00000595647.1_RNA|AC010127.3_ENST00000597623.1_RNA	NM_001165963.1|NM_001202435.1	NP_001159435.1|NP_001189364.1	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha subunit	1811						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(4)|breast(5)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(8)|large_intestine(33)|lung(87)|ovary(7)|pancreas(1)|prostate(9)|skin(23)|upper_aerodigestive_tract(2)|urinary_tract(1)	200					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	TTCTCCCAAACCTCATAGAAC	0.463000													35	54					0	0	0.004289	0	0
NDST1	3340	broad.mit.edu	37	5	149900862	149900862	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:149900862C>T	ENST00000261797.6	+	2	548	c.46C>T	c.(46-48)Ccg>Tcg	p.P16S	NDST1_ENST00000523767.1_Missense_Mutation_p.P16S	NM_001543.4	NP_001534.1	P52848	NDST1_HUMAN	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1	16					heparan sulfate proteoglycan biosynthetic process|inflammatory response	Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(1)|large_intestine(6)|lung(10)|ovary(3)|skin(3)|upper_aerodigestive_tract(1)	34		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCACGTGTCCCCGCAGGCTGT	0.647000													24	58					0	0	0.002299	0	0
SETD4	54093	broad.mit.edu	37	21	37417918	37417918	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:37417918G>A	ENST00000399215.1	-	5	2060	c.688C>T	c.(688-690)Ccg>Tcg	p.P230S	SETD4_ENST00000399208.2_Missense_Mutation_p.P230S|SETD4_ENST00000332131.4_Missense_Mutation_p.P230S|SETD4_ENST00000481477.1_5'UTR|SETD4_ENST00000399212.1_Missense_Mutation_p.P206S|SETD4_ENST00000399201.1_Missense_Mutation_p.P206S|SETD4_ENST00000399205.1_Missense_Mutation_p.P206S|SETD4_ENST00000399207.1_Missense_Mutation_p.P230S			Q9NVD3	SETD4_HUMAN	SET domain containing 4	230	SET.									autonomic_ganglia(1)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|prostate(1)	15						TCCAGGTACGGAGCGAGTGCA	0.587000													7	24					0	0	0.003080	0	0
ANKEF1	63926	broad.mit.edu	37	20	10030785	10030785	+	Missense_Mutation	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:10030785A>T	ENST00000378380.3	+	6	1897	c.1568A>T	c.(1567-1569)aAt>aTt	p.N523I	SNAP25-AS1_ENST00000603542.1_RNA|SNAP25-AS1_ENST00000421143.2_RNA|ANKEF1_ENST00000488991.1_3'UTR|ANKEF1_ENST00000378392.1_Missense_Mutation_p.N523I	NM_198798.1	NP_942093.1			ankyrin repeat and EF-hand domain containing 1																		ATGAAGGATAATTATTACAAA	0.428000													18	54					0	0	0.001523	0	0
ITLN1	55600	broad.mit.edu	37	1	160850994	160850994	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:160850994C>T	ENST00000326245.3	-	5	629	c.514G>A	c.(514-516)Gac>Aac	p.D172N	ITLN1_ENST00000487531.1_5'UTR	NM_017625.2	NP_060095.2	Q8WWA0	ITLN1_HUMAN	intelectin 1 (galactofuranose binding)	172	Fibrinogen C-terminal.				positive regulation of glucose import|positive regulation of protein phosphorylation|response to nematode|signal transduction	anchored to membrane|brush border membrane|extracellular region|membrane raft	receptor binding|sugar binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	21	all_cancers(52;2.99e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			AAGCCAGTGTCCGTGCGGTAC	0.562000													84	45					0	0	0.003610	0	0
KCNA5	3741	broad.mit.edu	37	12	5154975	5154975	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:5154975G>A	ENST00000252321.3	+	1	1891	c.1662G>A	c.(1660-1662)cgG>cgA	p.R554R		NM_002234.3	NP_002225.2	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 5	554						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|liver(1)|lung(21)|ovary(5)|prostate(2)|upper_aerodigestive_tract(2)	52						GAGTCCAGCGGAAGGTCAGCG	0.637000													7	19					0	0	0.001984	0	0
MYH3	4621	broad.mit.edu	37	17	10541482	10541482	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:10541482C>T	ENST00000583535.1	-	27	3694	c.3607G>A	c.(3607-3609)Gag>Aag	p.E1203K	MYH3_ENST00000226209.7_Missense_Mutation_p.E1203K	NM_002470.3	NP_002461.2	P11055	MYH3_HUMAN	myosin, heavy chain 3, skeletal muscle, embryonic	1203					muscle filament sliding|muscle organ development	cytosol|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(5)|large_intestine(18)|lung(30)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	83						TCCCCAAGCTCGGCCACACTA	0.602000													23	31					0	0	0.002299	0	0
SMG8	55181	broad.mit.edu	37	17	57290427	57290427	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:57290427C>T	ENST00000543872.2	+	4	2507	c.2243C>T	c.(2242-2244)cCa>cTa	p.P748L	CTD-2510F5.6_ENST00000577660.1_Intron|SMG8_ENST00000300917.5_Missense_Mutation_p.P748L|SMG8_ENST00000580498.1_3'UTR			Q8ND04	SMG8_HUMAN	SMG8 nonsense mediated mRNA decay factor	748					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding			NS(1)|breast(5)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|lung(9)|ovary(3)|prostate(1)|skin(1)	33						GAGTATCTCCCAGGCATGCTA	0.443000													69	28					0	0	0.003610	0	0
ABCA2	20	broad.mit.edu	37	9	139910620	139910620	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:139910620G>A	ENST00000265662.5	-	22	3258	c.3111C>T	c.(3109-3111)atC>atT	p.I1037I	ABCA2_ENST00000341511.6_Silent_p.I1037I|ABCA2_ENST00000371605.3_Silent_p.I1036I			Q9BZC7	ABCA2_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 2	1036	ABC transporter 1.				cholesterol homeostasis|lipid metabolic process|regulation of intracellular cholesterol transport|regulation of transcription from RNA polymerase II promoter|response to drug|response to steroid hormone stimulus	ATP-binding cassette (ABC) transporter complex|cytoplasmic membrane-bounded vesicle|endosome|integral to membrane|microtubule organizing center	ATP binding|ATPase activity, coupled to transmembrane movement of substances			central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|liver(1)|lung(25)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	41	all_cancers(76;0.16)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		GGCCGGTCAGGATGGACCTGG	0.657000													18	24					0	0	0.001882	0	0
KRT7	3855	broad.mit.edu	37	12	52641960	52641960	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:52641960G>A	ENST00000331817.5	+	8	1388		c.e8-1		KRT7_ENST00000552322.1_Splice_Site	NM_005556.3	NP_005547.3	P08729	K2C7_HUMAN	keratin 7						cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity			endometrium(1)|kidney(1)|large_intestine(3)|lung(5)|prostate(2)|stomach(1)|urinary_tract(1)	14				BRCA - Breast invasive adenocarcinoma(357;0.105)		TCTGCCCCCAGGTTGGCTGGA	0.582000													12	45					0	0	0.001855	0	0
SEMA3D	223117	broad.mit.edu	37	7	84666346	84666346	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:84666346G>A	ENST00000284136.6	-	10	1093	c.1050C>T	c.(1048-1050)tcC>tcT	p.S350S	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	350	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						CTTTGAAGATGGAGCTGGAAA	0.398000													14	14					0	0	0.001855	0	0
PLCL1	5334	broad.mit.edu	37	2	198949641	198949641	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:198949641C>T	ENST00000428675.1	+	2	1798	c.1400C>T	c.(1399-1401)tCc>tTc	p.S467F	PLCL1_ENST00000437704.2_Missense_Mutation_p.S369F	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	467	PI-PLC X-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	ACCCATGTTTCCTTTCGAAGT	0.408000													9	12					0	0	0.004482	0	0
NLRP2	55655	broad.mit.edu	37	19	55496493	55496493	+	Silent	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55496493T>C	ENST00000543010.1	+	7	2252	c.2109T>C	c.(2107-2109)ggT>ggC	p.G703G	NLRP2_ENST00000339757.7_Silent_p.G681G|NLRP2_ENST00000263437.6_Silent_p.G700G|NLRP2_ENST00000448584.2_Silent_p.G703G|NLRP2_ENST00000537859.1_Silent_p.G681G|NLRP2_ENST00000427260.2_Silent_p.G680G|NLRP2_ENST00000391721.4_Silent_p.G679G|NLRP2_ENST00000538819.1_Silent_p.G679G	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	703					apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		ATCTGATGGGTCTAGCAATCA	0.453000													20	57					0	0	0.001523	0	0
PDE6A	5145	broad.mit.edu	37	5	149294570	149294570	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:149294570C>T	ENST00000255266.5	-	6	1053	c.933_splice	c.e6-1	p.E312_splice		NM_000440.2	NP_000431.2	P16499	PDE6A_HUMAN	phosphodiesterase 6A, cGMP-specific, rod, alpha	312	GAF 2.				cytosolic calcium ion homeostasis|GMP metabolic process|platelet activation|signal transduction|visual perception	cytosol|plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(13)|ovary(2)|pancreas(1)|prostate(2)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)	44			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			AAGTTAATTTCCTGGCAAAAG	0.368000													50	58					0	0	0.003610	0	0
EGFR	1956	broad.mit.edu	37	7	55229314	55229314	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:55229314C>T	ENST00000275493.2	+	13	1798	c.1621C>T	c.(1621-1623)Ctt>Ttt	p.L541F	EGFR_ENST00000455089.1_Missense_Mutation_p.L496F|EGFR_ENST00000344576.2_Missense_Mutation_p.L541F|EGFR_ENST00000342916.3_Missense_Mutation_p.L541F|EGFR_ENST00000454757.2_Missense_Mutation_p.L488F|EGFR_ENST00000442591.1_Missense_Mutation_p.L541F	NM_005228.3	NP_005219.2	P00533	EGFR_HUMAN	epidermal growth factor receptor	541					activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			NS(2)|adrenal_gland(5)|biliary_tract(8)|bone(3)|breast(18)|central_nervous_system(106)|endometrium(26)|eye(3)|haematopoietic_and_lymphoid_tissue(9)|kidney(11)|large_intestine(85)|liver(2)|lung(13575)|oesophagus(21)|ovary(38)|pancreas(3)|peritoneum(11)|pleura(2)|prostate(35)|salivary_gland(11)|skin(9)|small_intestine(1)|soft_tissue(4)|stomach(41)|thymus(2)|thyroid(14)|upper_aerodigestive_tract(59)|urinary_tract(6)	14110	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	CAAGTGCAACCTTCTGGAGGG	0.532000		8	"""A, O, Mis"""		"""glioma, NSCLC"""	NSCLC			Lung Cancer, Familial Clustering of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			41	119					0	0	0.003610	0	0
DRD3	1814	broad.mit.edu	37	3	113890723	113890723	+	Silent	SNP	G	G	A	rs149122773		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:113890723G>A	ENST00000383673.2	-	2	547	c.117C>T	c.(115-117)ctC>ctT	p.L39L	DRD3_ENST00000460779.1_Silent_p.L39L|DRD3_ENST00000467632.1_Silent_p.L39L|DRD3_ENST00000295881.7_Silent_p.L39L	NM_000796.3	NP_000787.2	P35462	DRD3_HUMAN	dopamine receptor D3	39					activation of adenylate cyclase activity by dopamine receptor signaling pathway|arachidonic acid secretion|behavioral response to cocaine|cellular calcium ion homeostasis|circadian regulation of gene expression|G-protein coupled receptor internalization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|locomotory behavior|musculoskeletal movement, spinal reflex action|negative regulation of blood pressure|negative regulation of oligodendrocyte differentiation|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|positive regulation of dopamine receptor signaling pathway|positive regulation of mitosis|prepulse inhibition|regulation of dopamine secretion|response to drug|response to histamine|response to morphine|social behavior|visual learning	integral to plasma membrane	dopamine D3 receptor activity|drug binding	p.L39L(1)		central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(4)|liver(1)|lung(23)|ovary(1)|pancreas(1)|skin(1)	36					Apomorphine(DB00714)|Chlorprothixene(DB01239)|Cocaine(DB00907)|Methotrimeprazine(DB01403)|Olanzapine(DB00334)|Pramipexole(DB00413)|Ropinirole(DB00268)|Ziprasidone(DB00246)	TGGCCAGGATGAGCGCGCAGT	0.612000													15	22					0	0	0.002450	0	0
UBR4	23352	broad.mit.edu	37	1	19454739	19454739	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:19454739G>A	ENST00000375267.2	-	62	9080	c.9077C>T	c.(9076-9078)tCc>tTc	p.S3026F	UBR4_ENST00000375217.2_Missense_Mutation_p.S3019F|UBR4_ENST00000375254.3_Missense_Mutation_p.S3026F|UBR4_ENST00000375226.2_Missense_Mutation_p.S3002F			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	3026					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AATAAGCTGGGAGAGCAGGTT	0.443000													43	105					0	0	0.003214	0	0
SUOX	6821	broad.mit.edu	37	12	56397697	56397697	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:56397697C>T	ENST00000394109.3	+	3	1248	c.524C>T	c.(523-525)cCt>cTt	p.P175L	SUOX_ENST00000551841.2_Intron|SUOX_ENST00000548274.1_Missense_Mutation_p.P175L|SUOX_ENST00000550478.1_3'UTR|SUOX_ENST00000266971.3_Missense_Mutation_p.P175L|SUOX_ENST00000394115.2_Missense_Mutation_p.P175L|SUOX_ENST00000356124.4_Missense_Mutation_p.P175L			P51687	SUOX_HUMAN	sulfite oxidase	175	Hinge (By similarity).					mitochondrial intermembrane space	electron carrier activity|molybdenum ion binding|sulfite oxidase activity			central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(6)	15			UCEC - Uterine corpus endometrioid carcinoma (6;0.0471)|OV - Ovarian serous cystadenocarcinoma(18;0.119)			ACCTCTGACCCTTATGCTGAT	0.547000													21	50					0	0	0.001523	0	0
FRMPD1	22844	broad.mit.edu	37	9	37744757	37744757	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:37744757G>A	ENST00000539465.1	+	16	3321	c.2728G>A	c.(2728-2730)Gag>Aag	p.E910K	FRMPD1_ENST00000377765.3_Missense_Mutation_p.E910K|RP11-613M10.9_ENST00000540557.1_Intron			Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	910						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		TCCTCTGAGGGAGACCAAGAG	0.582000													17	37					0	0	0.004007	0	0
CAMLG	819	broad.mit.edu	37	5	134076819	134076819	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:134076819C>T	ENST00000297156.2	+	2	359	c.239C>T	c.(238-240)tCc>tTc	p.S80F	CAMLG_ENST00000514518.1_Intron	NM_001745.3	NP_001736.1	P49069	CAMLG_HUMAN	calcium modulating ligand	80					defense response	endoplasmic reticulum|integral to membrane				NS(1)|cervix(1)|kidney(3)|lung(3)|prostate(1)	9			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Cyclosporine(DB00091)	AGCGTTCCTTCCGTTTCAAAG	0.453000													36	54					0	0	0.005524	0	0
OR6Q1	219952	broad.mit.edu	37	11	57799156	57799156	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57799156C>T	ENST00000302622.3	+	1	755	c.732C>T	c.(730-732)acC>acT	p.T244T	OR9Q1_ENST00000335397.3_Intron	NM_001005186.2	NP_001005186.2	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q, member 1	244					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			biliary_tract(1)|central_nervous_system(1)|kidney(1)|large_intestine(3)|lung(11)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21		Breast(21;0.0707)|all_epithelial(135;0.142)				CCTTCTCTACCTGTGCAGCTC	0.527000													42	129					0	0	0.002852	0	0
MUC17	140453	broad.mit.edu	37	7	100679002	100679002	+	Silent	SNP	A	A	G	rs142375735		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:100679002A>G	ENST00000306151.4	+	3	4369	c.4305A>G	c.(4303-4305)tcA>tcG	p.S1435S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	1435	59 X approximate tandem repeats.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					AAGCCACTTCATCTCCTACAA	0.522000													72	117					0	0	0.003610	0	0
IPO11	51194	broad.mit.edu	37	5	61779894	61779894	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:61779894C>T	ENST00000325324.6	+	11	1248	c.1079C>T	c.(1078-1080)cCt>cTt	p.P360L	KIF2A_ENST00000509663.2_Intron|IPO11_ENST00000409296.3_Missense_Mutation_p.P400L	NM_016338.4	NP_057422.3	Q9UI26	IPO11_HUMAN	importin 11	360						cytoplasm|nucleus	protein binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(14)|skin(4)|stomach(2)	30		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		TTCACATATCCTACTTTGACA	0.353000													19	61					0	0	0.001523	0	0
CDR1	1038	broad.mit.edu	37	X	139866474	139866474	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:139866474G>A	ENST00000370532.2	-	1	249	c.58C>T	c.(58-60)Cct>Tct	p.P20S		NM_004065.2	NP_004056.2	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1, 34kDa	20	23 X 6 AA approximate repeats.									breast(1)|endometrium(3)|large_intestine(3)|lung(11)|prostate(2)|skin(4)|urinary_tract(1)	25	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				TCCAACAAAGGTATGTCTTCC	0.423000													98	14					0	0	0.003610	0	0
NBPF20	100288142	broad.mit.edu	37	1	148344720	148344720	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:148344720G>A	ENST00000369202.1	-	3	395	c.198C>T	c.(196-198)ctC>ctT	p.L66L	NBPF20_ENST00000414710.2_Silent_p.L66L					neuroblastoma breakpoint family, member 20											breast(1)|cervix(2)|endometrium(6)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|urinary_tract(1)	27						TAAATTTTATGAGGTCTTTAC	0.537000													13	252					0	0	0.006122	0	0
GPR146	115330	broad.mit.edu	37	7	1097763	1097763	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:1097763C>T	ENST00000397095.1	+	2	835	c.612C>T	c.(610-612)ctC>ctT	p.L204L	C7orf50_ENST00000488073.1_Intron|C7orf50_ENST00000357429.6_Intron|GPR146_ENST00000297468.3_Silent_p.L204L|C7orf50_ENST00000397098.3_Intron|RP11-449P15.1_ENST00000549241.1_RNA|C7orf50_ENST00000397100.2_Intron			Q96CH1	GP146_HUMAN	G protein-coupled receptor 146	204						integral to membrane|plasma membrane	G-protein coupled receptor activity			autonomic_ganglia(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(1)|ovary(1)|skin(1)	8		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;1.74e-15)		TGGCCACCCTCTACGCGCTGG	0.692000													4	25					0	0	0.000248	0	0
TNFRSF8	943	broad.mit.edu	37	1	12175783	12175783	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:12175783C>T	ENST00000263932.2	+	8	1165	c.943C>T	c.(943-945)Cag>Tag	p.Q315*	TNFRSF8_ENST00000417814.2_Nonsense_Mutation_p.Q204*	NM_001243.3	NP_001234.2	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily, member 8	315					cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(4)|lung(12)|ovary(1)|pancreas(1)|skin(2)|urinary_tract(1)	27	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		CACCAAGCCCCAGGGTAAGCA	0.622000													9	17					0	0	0.000673	0	0
HERC6	55008	broad.mit.edu	37	4	89311825	89311825	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:89311825G>A	ENST00000380265.5	+	4	641	c.458G>A	c.(457-459)gGa>gAa	p.G153E	HERC6_ENST00000264346.7_Missense_Mutation_p.G153E|HERC6_ENST00000273960.3_Missense_Mutation_p.G153E	NM_001165136.1	NP_001158608.1	Q8IVU3	HERC6_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6	153					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(6)|ovary(1)	11		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		TTTTCGTGGGGAAAGAACAGC	0.478000													16	11					0	0	0.006122	0	0
ANPEP	290	broad.mit.edu	37	15	90328675	90328675	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:90328675G>A	ENST00000300060.6	-	21	3122	c.2809C>T	c.(2809-2811)Ctg>Ttg	p.L937L		NM_001150.2	NP_001141.2	P15144	AMPN_HUMAN	alanyl (membrane) aminopeptidase	937	Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|liver(1)|lung(20)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(3)	57	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	GCTTGCTCCAGGGCCCGGGTG	0.542000													35	61					0	0	0.006999	0	0
OR2G2	81470	broad.mit.edu	37	1	247752336	247752336	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:247752336C>T	ENST00000320065.1	+	1	675	c.675C>T	c.(673-675)gcC>gcT	p.A225A	RP11-978I15.10_ENST00000446347.1_RNA|RP11-978I15.10_ENST00000435333.1_RNA	NM_001001915.1	NP_001001915.1	Q8NGZ5	OR2G2_HUMAN	olfactory receptor, family 2, subfamily G, member 2	225					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(4)|kidney(4)|large_intestine(3)|lung(30)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GCTACATTGCCCACGCAGTGT	0.498000													16	94					0	0	0.004007	0	0
TRGV3	6976	broad.mit.edu	37	7	38398154	38398154	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:38398154C>T	ENST00000390346.2	-	0	495																											GAATCATTTTCAATTAGATTT	0.483000													34	60					0	0	0.003755	0	0
MCRS1	10445	broad.mit.edu	37	12	49958267	49958267	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:49958267G>A	ENST00000550165.1	-	7	820	c.554C>T	c.(553-555)tCc>tTc	p.S185F	MCRS1_ENST00000546244.1_5'UTR|MCRS1_ENST00000357123.4_Missense_Mutation_p.S198F|MCRS1_ENST00000343810.4_Missense_Mutation_p.S185F			Q96EZ8	MCRS1_HUMAN	microspherule protein 1	185					DNA recombination|DNA repair|protein modification process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|Ino80 complex|MLL1 complex|nucleolus	protein binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(4)|lung(11)	23						CACTCACTTGGAGATGACAGG	0.607000													7	11					0	0	0.004482	0	0
LHCGR	3973	broad.mit.edu	37	2	48915873	48915873	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:48915873C>T	ENST00000294954.7	-	11	1084	c.1063G>A	c.(1063-1065)Gat>Aat	p.D355N	STON1-GTF2A1L_ENST00000402114.2_Intron|LHCGR_ENST00000344775.3_Missense_Mutation_p.D293N|LHCGR_ENST00000405626.1_Missense_Mutation_p.D328N|LHCGR_ENST00000403273.1_Intron|LHCGR_ENST00000401907.1_Intron	NM_000233.3	NP_000224.2	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	355					male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			NS(1)|breast(6)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|liver(1)|lung(23)|ovary(3)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	56		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	CCCATAATATCTTCACAGGGA	0.443000													36	85					0	0	0.004878	0	0
ENTHD1	150350	broad.mit.edu	37	22	40161379	40161379	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:40161379G>A	ENST00000325157.6	-	6	1318	c.1068C>T	c.(1066-1068)ttC>ttT	p.F356F		NM_152512.3	NP_689725.2	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	356										breast(2)|endometrium(1)|kidney(6)|large_intestine(6)|lung(11)|ovary(3)|skin(3)	32	Melanoma(58;0.0749)					CCTGGTTATGGAAAGTAGAAT	0.413000													34	36					0	0	0.004289	0	0
CYP21A1P	1590	broad.mit.edu	37	6	31976210	31976210	+	RNA	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31976210T>C	ENST00000342991.6	+	0	1953					NR_040090.1		Q5ST44	Q5ST44_HUMAN									electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen										GGTACCTCAGTTTCTCCTTTA	0.647000													12	60					0	0	0.002450	0	0
FAM98C	147965	broad.mit.edu	37	19	38899412	38899412	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:38899412G>A	ENST00000252530.5	+	8	959	c.940G>A	c.(940-942)Gac>Aac	p.D314N	FAM98C_ENST00000343358.7_Missense_Mutation_p.D232N|FAM98C_ENST00000588262.1_Missense_Mutation_p.R180K	NM_174905.3	NP_777565.3	Q17RN3	FA98C_HUMAN	family with sequence similarity 98, member C	314										endometrium(2)|large_intestine(3)|lung(6)|pancreas(1)|prostate(1)|skin(1)|urinary_tract(1)	15	all_cancers(60;3.95e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CAACGTTCCAGACCGGGGGGG	0.562000													28	70					0	0	0.005443	0	0
SPATA18	132671	broad.mit.edu	37	4	52944959	52944959	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:52944959C>T	ENST00000295213.4	+	8	1453	c.1079C>T	c.(1078-1080)tCg>tTg	p.S360L	SPATA18_ENST00000419395.2_Missense_Mutation_p.S328L	NM_145263.2	NP_660306.1	Q8TC71	MIEAP_HUMAN	spermatogenesis associated 18	360					mitochondrial protein catabolic process|mitochondrion degradation by induced vacuole formation|response to DNA damage stimulus	mitochondrial outer membrane	protein binding			breast(1)|endometrium(3)|kidney(2)|large_intestine(8)|lung(20)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	41			GBM - Glioblastoma multiforme(4;1.77e-13)|LUSC - Lung squamous cell carcinoma(32;0.00204)			GTGAGAAAATCGTTGACACCA	0.378000													12	153					0	0	0.001368	0	0
OC90	729330	broad.mit.edu	37	8	133051336	133051336	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:133051336G>A	ENST00000262283.5	-	10	1179	c.1080C>T	c.(1078-1080)acC>acT	p.T360T	OC90_ENST00000603859.1_Silent_p.T164T|OC90_ENST00000443356.2_Silent_p.T164T|OC90_ENST00000254627.3_Silent_p.T164T			Q02509	OC90_HUMAN	otoconin 90	164	Phospholipase A2-like 2.				lipid catabolic process|phospholipid metabolic process		calcium ion binding|phospholipase A2 activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(23)|ovary(2)|prostate(1)|skin(1)	37	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)			CCTTATCACAGGTACACAGCA	0.527000													12	32					0	0	0.000978	0	0
SOCS2	8835	broad.mit.edu	37	12	93968785	93968785	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:93968785C>T	ENST00000340600.2	+	3	1025	c.427C>T	c.(427-429)Ccc>Tcc	p.P143S	SOCS2_ENST00000549206.1_Missense_Mutation_p.P143S|SOCS2_ENST00000548537.1_3'UTR|SOCS2_ENST00000536696.2_Missense_Mutation_p.P143S|SOCS2_ENST00000551556.1_Missense_Mutation_p.P143S|SOCS2_ENST00000549122.1_Missense_Mutation_p.P143S	NM_001270468.1|NM_001270469.1|NM_001270471.1|NM_003877.4	NP_001257397.1|NP_001257398.1|NP_001257400.1|NP_003868.1	O14508	SOCS2_HUMAN	suppressor of cytokine signaling 2	143	SH2.				anti-apoptosis|growth hormone receptor signaling pathway|JAK-STAT cascade|negative regulation of signal transduction|regulation of cell growth|response to estradiol stimulus	cytoplasm	growth hormone receptor binding|insulin-like growth factor receptor binding|JAK pathway signal transduction adaptor activity|prolactin receptor binding|SH3/SH2 adaptor activity			cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|ovary(1)	14						TCCAGAAGCCCCCCGGAACGG	0.478000													13	37					0	0	0.003163	0	0
RIMBP2	23504	broad.mit.edu	37	12	130927115	130927115	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:130927115C>T	ENST00000261655.4	-	8	894	c.731G>A	c.(730-732)gGg>gAg	p.G244E	RIMBP2_ENST00000535703.1_Missense_Mutation_p.G152E|RIMBP2_ENST00000536002.1_Missense_Mutation_p.G152E	NM_015347.4	NP_056162.4	O15034	RIMB2_HUMAN	RIMS binding protein 2	244						cell junction|synapse				NS(2)|breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(33)|ovary(3)|pancreas(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(5)|urinary_tract(1)	96	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.213)		OV - Ovarian serous cystadenocarcinoma(86;4.29e-06)|all cancers(50;4.56e-05)|Epithelial(86;5.41e-05)		CTGCTCGTTCCCCAGCGTGCT	0.597000													11	41					0	0	0.000978	0	0
C6orf223	221416	broad.mit.edu	37	6	43968723	43968723	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:43968723G>A	ENST00000439969.2	+	2	97	c.94G>A	c.(94-96)Gag>Aag	p.E32K	RP5-1120P11.1_ENST00000422059.1_RNA|C6orf223_ENST00000448947.2_Intron|RP5-1120P11.1_ENST00000607590.1_RNA|C6orf223_ENST00000336600.5_Intron			Q8N319	CF223_HUMAN	chromosome 6 open reading frame 223	0										central_nervous_system(1)|lung(2)|pancreas(1)|prostate(1)|urinary_tract(1)	6	all_cancers(18;2.28e-07)|all_epithelial(2;1.62e-08)|Lung NSC(15;0.000172)|all_lung(25;0.000533)|Hepatocellular(11;0.00309)|Ovarian(13;0.0437)		all cancers(41;0.00141)|Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.217)			GTTGAGGAAGGAGGGAGTAGA	0.567000													9	60					0	0	0.006214	0	0
AGXT2	64902	broad.mit.edu	37	5	35010218	35010218	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:35010218C>T	ENST00000231420.6	-	12	1425	c.1225G>A	c.(1225-1227)Gaa>Aaa	p.E409K		NM_031900.3	NP_114106.1	Q9BYV1	AGT2_HUMAN	alanine--glyoxylate aminotransferase 2	409					glyoxylate metabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process	mitochondrial matrix	(R)-3-amino-2-methylpropionate-pyruvate transaminase activity|alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(8)|lung(18)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	41	all_lung(31;4.52e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)	GBM - Glioblastoma multiforme(108;0.181)	Glycine(DB00145)|L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)|Pyruvic acid(DB00119)	GTCCCAACTTCTTGACTGTTT	0.398000													50	56					0	0	0.003610	0	0
MACROD2	140733	broad.mit.edu	37	20	15967391	15967391	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:15967391G>A	ENST00000217246.4	+	14	1400	c.1005G>A	c.(1003-1005)acG>acA	p.T335T	MACROD2_ENST00000407045.3_5'UTR|MACROD2_ENST00000378058.3_Silent_p.T100T|MACROD2_ENST00000310348.4_Silent_p.T335T|MACROD2_ENST00000402914.1_Silent_p.T100T	NM_080676.5	NP_542407.2	A1Z1Q3	MACD2_HUMAN	MACRO domain containing 2	335	Glu-rich.		T -> M (in dbSNP:rs41275442).							breast(2)|kidney(4)|large_intestine(5)|lung(8)|skin(1)	20		all_neural(2;0.0381)|Acute lymphoblastic leukemia(2;0.175)				ATGATTCAACGAAGAATGAAA	0.338000													10	53					0	0	0.000673	0	0
ZFYVE28	57732	broad.mit.edu	37	4	2274994	2274994	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:2274994C>T	ENST00000290974.2	-	10	2568	c.2229G>A	c.(2227-2229)acG>acA	p.T743T	ZFYVE28_ENST00000515312.1_Silent_p.T673T|ZFYVE28_ENST00000511071.1_Silent_p.T713T|ZFYVE28_ENST00000508471.1_Silent_p.T48T	NM_020972.2	NP_066023.2	Q9HCC9	LST2_HUMAN	zinc finger, FYVE domain containing 28	743					negative regulation of epidermal growth factor receptor activity	cytosol|early endosome membrane	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(17)|ovary(1)|pancreas(1)|prostate(1)|skin(4)	31						TGGCATAGTTCGTCTGCAGCT	0.537000													98	130					0	0	0.003610	0	0
ARAP1	116985	broad.mit.edu	37	11	72406094	72406094	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:72406094G>A	ENST00000359373.5	-	27	4476	c.3625C>T	c.(3625-3627)Cgc>Tgc	p.R1209C	ARAP1_ENST00000393605.3_Missense_Mutation_p.R969C|ARAP1_ENST00000429686.1_Missense_Mutation_p.R903C|ARAP1_ENST00000426523.1_Missense_Mutation_p.R964C|ARAP1_ENST00000393609.3_Missense_Mutation_p.R1209C|ARAP1_ENST00000495878.1_5'UTR|ARAP1_ENST00000455638.2_Missense_Mutation_p.R1209C|ARAP1_ENST00000334211.8_Missense_Mutation_p.R964C			Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	1209	Ras-associating.				actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			cervix(2)|endometrium(2)|large_intestine(10)|lung(8)|ovary(1)|skin(3)|urinary_tract(1)	27						ACGTTCCGGCGATCCAGGATC	0.612000													98	63					0	0	0.003610	0	0
USP29	57663	broad.mit.edu	37	19	57641248	57641248	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:57641248G>A	ENST00000254181.4	+	4	1659	c.1205G>A	c.(1204-1206)gGg>gAg	p.G402E	USP29_ENST00000598197.1_Missense_Mutation_p.G402E	NM_020903.2	NP_065954.1	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	402					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			breast(3)|endometrium(4)|kidney(3)|large_intestine(15)|lung(47)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	85		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAAGAATGTGGGGATGAAAAT	0.398000													21	49					0	0	0.003954	0	0
CLIC1	1192	broad.mit.edu	37	6	31700063	31700063	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31700063C>T	ENST00000375780.2	-	6	1067	c.495G>A	c.(493-495)agG>agA	p.R165R	CLIC1_ENST00000395892.1_Silent_p.R165R|CLIC1_ENST00000375784.3_Silent_p.R165R|CLIC1_ENST00000375779.2_Silent_p.R165R			O00299	CLIC1_HUMAN	chloride intracellular channel 1	165	GST C-terminal.				signal transduction	brush border|chloride channel complex|cytoplasm|membrane fraction|nuclear membrane|plasma membrane|soluble fraction	protein binding|voltage-gated chloride channel activity			central_nervous_system(1)|endometrium(1)|lung(3)|ovary(1)|skin(1)	7						CCAAAAACTTCCTCTGAGAGA	0.488000													317	1335					0	0	0.003610	0	0
SCUBE2	57758	broad.mit.edu	37	11	9111275	9111275	+	Missense_Mutation	SNP	C	C	T	rs149203158		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:9111275C>T	ENST00000457346.2	-	2	309	c.235G>A	c.(235-237)Ggg>Agg	p.G79R	SCUBE2_ENST00000450649.2_Missense_Mutation_p.G79R|SCUBE2_ENST00000534295.1_5'UTR|SCUBE2_ENST00000520467.1_Missense_Mutation_p.G79R|SCUBE2_ENST00000309263.3_Missense_Mutation_p.G79R			Q9NQ36	SCUB2_HUMAN	signal peptide, CUB domain, EGF-like 2	79	EGF-like 1; calcium-binding (Potential).					extracellular region	calcium ion binding			breast(1)|endometrium(5)|kidney(3)|large_intestine(15)|liver(1)|lung(10)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	42				all cancers(16;8.57e-09)|Epithelial(150;4.42e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0116)		CTGCCTTCCCCTTGGTAGCCA	0.577000													42	41					0	0	0.002222	0	0
GPR155	151556	broad.mit.edu	37	2	175333751	175333751	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:175333751G>A	ENST00000392552.2	-	5	1309	c.1071C>T	c.(1069-1071)atC>atT	p.I357I	GPR155_ENST00000392551.2_Silent_p.I357I|GPR155_ENST00000295500.4_Silent_p.I357I	NM_001267051.1|NM_152529.6	NP_001253980.1|NP_689742.4	Q7Z3F1	GP155_HUMAN	G protein-coupled receptor 155	357					intracellular signal transduction|transmembrane transport	integral to membrane				breast(2)|endometrium(5)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(2)|urinary_tract(2)	26						AAACGTACATGATGGGAGCAG	0.393000													27	32					0	0	0.004656	0	0
APAF1	317	broad.mit.edu	37	12	99060005	99060005	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:99060005T>C	ENST00000357310.1	+	9	1809	c.1232T>C	c.(1231-1233)gTt>gCt	p.V411A	APAF1_ENST00000333991.1_Intron|APAF1_ENST00000359972.2_Missense_Mutation_p.V400A|APAF1_ENST00000547045.1_Missense_Mutation_p.V411A|APAF1_ENST00000549007.1_Missense_Mutation_p.V411A|APAF1_ENST00000551964.1_Missense_Mutation_p.V411A|APAF1_ENST00000339433.3_Missense_Mutation_p.V411A|APAF1_ENST00000550527.1_Missense_Mutation_p.V400A|APAF1_ENST00000552268.1_Intron	NM_181868.1	NP_863658.1	O14727	APAF_HUMAN	apoptotic peptidase activating factor 1	411	NB-ARC.				activation of caspase activity by cytochrome c|defense response|induction of apoptosis by intracellular signals|nervous system development	cytosol|Golgi apparatus|nucleus	ATP binding|caspase activator activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(13)|liver(1)|lung(15)|ovary(2)|prostate(2)|skin(1)	42					Adenosine triphosphate(DB00171)	ACTGAAGAAGTTGAAGACATA	0.348000													27	86					0	0	0.001786	0	0
KRT84	3890	broad.mit.edu	37	12	52778905	52778905	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:52778905G>A	ENST00000257951.3	-	1	531	c.465C>T	c.(463-465)gaC>gaT	p.D155D	RP3-416H24.4_ENST00000547174.1_RNA	NM_033045.3	NP_149034.2	Q9NSB2	KRT84_HUMAN	keratin 84	155	Head.					keratin filament	structural constituent of epidermis			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|liver(1)|lung(10)|skin(3)	27	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		GGGCATTGGGGTCAATCTCCA	0.502000													57	312					0	0	0.003610	0	0
FBN2	2201	broad.mit.edu	37	5	127640745	127640745	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:127640745C>T	ENST00000508053.1	-	51	6678	c.5704G>A	c.(5704-5706)Gtt>Att	p.V1902I	FBN2_ENST00000262464.4_Missense_Mutation_p.V1902I			P35556	FBN2_HUMAN	fibrillin 2	1902	EGF-like 31; calcium-binding.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|breast(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(37)|liver(1)|lung(89)|ovary(9)|pancreas(2)|prostate(6)|skin(10)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	197		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGACTGCAAACGTTAGGAATT	0.368000													12	36					0	0	0.001855	0	0
QRICH1	54870	broad.mit.edu	37	3	49070589	49070589	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:49070589G>A	ENST00000395443.2	-	7	2331	c.1859C>T	c.(1858-1860)tCc>tTc	p.S620F	QRICH1_ENST00000479449.1_5'UTR|QRICH1_ENST00000357496.2_Missense_Mutation_p.S620F|QRICH1_ENST00000424300.1_Missense_Mutation_p.S620F	NM_198880.1	NP_942581.1	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	620										breast(2)|endometrium(5)|large_intestine(8)|lung(8)|ovary(1)|skin(1)	25				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CAGCAAGGTGGAGGGGGAGTG	0.517000													18	61					0	0	0.001882	0	0
NAA11	84779	broad.mit.edu	37	4	80246504	80246504	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:80246504C>T	ENST00000286794.4	-	1	700	c.528G>A	c.(526-528)gaG>gaA	p.E176E	NAA11_ENST00000513733.1_5'UTR	NM_032693.2	NP_116082.1	Q9BSU3	NAA11_HUMAN	N(alpha)-acetyltransferase 11, NatA catalytic subunit	176						cytoplasm|nucleus	peptide alpha-N-acetyltransferase activity|protein binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|skin(2)	23						TCTCCTGGTTCTCCCTGGAGC	0.537000													15	17					0	0	0.004990	0	0
PLXNA1	5361	broad.mit.edu	37	3	126736441	126736441	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:126736441C>T	ENST00000393409.2	+	17	3450	c.3450C>T	c.(3448-3450)ccC>ccT	p.P1150P	PLXNA1_ENST00000251772.4_Silent_p.P1127P	NM_032242.3	NP_115618.3	Q9UIW2	PLXA1_HUMAN	plexin A1	1150	IPT/TIG 4.				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			breast(3)|central_nervous_system(5)|endometrium(10)|kidney(5)|large_intestine(4)|lung(32)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	67				GBM - Glioblastoma multiforme(114;0.155)		ACCCTGACCCCGTACTGGAGC	0.642000													46	141					0	0	0.003610	0	0
GBF1	8729	broad.mit.edu	37	10	104103904	104103904	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:104103904C>T	ENST00000369983.3	+	4	520	c.260C>T	c.(259-261)aCc>aTc	p.T87I		NM_001199378.1|NM_001199379.1|NM_004193.2	NP_001186307.1|NP_001186308.1|NP_004184.1	Q92538	GBF1_HUMAN	golgi brefeldin A resistant guanine nucleotide exchange factor 1	87					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(14)|kidney(8)|large_intestine(15)|lung(19)|ovary(1)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	71		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		CTGGCACTCACCTCTGTCAAC	0.498000													33	52					0	0	0.003271	0	0
COL3A1	1281	broad.mit.edu	37	2	189875061	189875061	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:189875061G>A	ENST00000304636.3	+	49	4151	c.3981G>A	c.(3979-3981)tgG>tgA	p.W1327*	COL3A1_ENST00000317840.5_Nonsense_Mutation_p.W1024*	NM_000090.3	NP_000081.1	P02461	CO3A1_HUMAN	collagen, type III, alpha 1	1327	Fibrillar collagen NC1.				axon guidance|cell-matrix adhesion|collagen biosynthetic process|collagen fibril organization|fibril organization|heart development|integrin-mediated signaling pathway|negative regulation of immune response|peptide cross-linking|platelet activation|response to cytokine stimulus|response to radiation|skin development|transforming growth factor beta receptor signaling pathway	collagen type III|extracellular space	extracellular matrix structural constituent|integrin binding|platelet-derived growth factor binding			NS(2)|breast(1)|central_nervous_system(7)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(60)|ovary(4)|pancreas(1)|prostate(5)|skin(10)|upper_aerodigestive_tract(3)|urinary_tract(3)	126			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.141)		Collagenase(DB00048)|Palifermin(DB00039)	AACACGTTTGGTTTGGAGAGT	0.393000													30	29					0	0	0.002836	0	0
OR8A1	390275	broad.mit.edu	37	11	124440145	124440145	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:124440145G>A	ENST00000284287.3	+	1	253	c.181G>A	c.(181-183)Ggc>Agc	p.G61S		NM_001005194.1	NP_001005194.1	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A, member 1	61					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			haematopoietic_and_lymphoid_tissue(1)|lung(16)|ovary(2)|prostate(1)|skin(2)	22		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		GGGGAACCTGGGCATGATCAC	0.502000													21	43					0	0	0.001216	0	0
EPHA2	1969	broad.mit.edu	37	1	16458768	16458768	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:16458768C>T	ENST00000358432.5	-	13	2270	c.2115_splice	c.e13-1	p.E706_splice		NM_004431.3	NP_004422.2	P29317	EPHA2_HUMAN	EPH receptor A2	706	Mediates interaction with ARHGEF16 and ELMO2.|Protein kinase.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	CCATCCTTCTCCTGCCGGAGC	0.657000													18	23					0	0	0.007413	0	0
LRRK2	120892	broad.mit.edu	37	12	40677810	40677810	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:40677810G>A	ENST00000298910.7	+	19	2433	c.2375G>A	c.(2374-2376)aGg>aAg	p.R792K	LRRK2_ENST00000343742.2_Missense_Mutation_p.R792K	NM_198578.3	NP_940980.3	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	792					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			NS(3)|biliary_tract(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(23)|large_intestine(31)|lung(55)|ovary(15)|pancreas(2)|prostate(4)|skin(4)|stomach(9)|upper_aerodigestive_tract(7)|urinary_tract(2)	181	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TTGCTCTTAAGGAGGCTGGCC	0.443000													27	59					0	0	0.007291	0	0
NCOA6	23054	broad.mit.edu	37	20	33345249	33345249	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:33345249G>A	ENST00000374796.2	-	8	3872	c.1302C>T	c.(1300-1302)tcC>tcT	p.S434S	NCOA6_ENST00000359003.2_Silent_p.S434S			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	434	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						CCTGCTGGAAGGAGGAGGGTG	0.582000													16	63					0	0	0.003163	0	0
MYRIP	25924	broad.mit.edu	37	3	40291796	40291796	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:40291796G>A	ENST00000302541.6	+	14	2688	c.2346G>A	c.(2344-2346)cgG>cgA	p.R782R	MYRIP_ENST00000396217.3_Silent_p.R693R|MYRIP_ENST00000425621.1_Silent_p.R717R|MYRIP_ENST00000459828.1_3'UTR|MYRIP_ENST00000539167.1_Silent_p.R595R|MYRIP_ENST00000444716.1_Silent_p.R782R	NM_015460.2	NP_056275.2	Q8NFW9	MYRIP_HUMAN	myosin VIIA and Rab interacting protein	782	Actin-binding.				intracellular protein transport		actin binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|liver(2)|lung(10)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34				KIRC - Kidney renal clear cell carcinoma(284;0.174)|Kidney(284;0.206)		CAAGAAGACGGGATCAGAAGC	0.438000													25	41					0	0	0.003330	0	0
GKN2	200504	broad.mit.edu	37	2	69174314	69174314	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:69174314G>A	ENST00000481498.1	-	4	298	c.280C>T	c.(280-282)Ctg>Ttg	p.L94L	GKN2_ENST00000328895.4_Silent_p.L94L			Q86XP6	GKN2_HUMAN	gastrokine 2	94	BRICHOS.					extracellular region				autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(7)|urinary_tract(1)	15						AGATTGTTCAGAGGAGGGATG	0.463000													28	108					0	0	0.001512	0	0
KLB	152831	broad.mit.edu	37	4	39409047	39409047	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:39409047C>T	ENST00000257408.4	+	1	575	c.478C>T	c.(478-480)Ccc>Tcc	p.P160S		NM_175737.3	NP_783864.1	Q86Z14	KLOTB_HUMAN	klotho beta	160	Glycosyl hydrolase-1 1.				carbohydrate metabolic process	integral to membrane|plasma membrane	cation binding|fibroblast growth factor binding|hydrolase activity, hydrolyzing O-glycosyl compounds			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|skin(6)	29						AAGGCTTTTCCCCGATGGAAT	0.383000													56	130					0	0	0.003610	0	0
IL7R	3575	broad.mit.edu	37	5	35876214	35876214	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:35876214G>A	ENST00000303115.3	+	8	1135	c.1006G>A	c.(1006-1008)Gag>Aag	p.E336K	IL7R_ENST00000343305.4_3'UTR	NM_002185.3	NP_002176.2	P16871	IL7RA_HUMAN	interleukin 7 receptor	336					immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			AGAAGAATCTGAGAAGCAGAG	0.478000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency						14	40					0	0	0.004007	0	0
ZFP69B	65243	broad.mit.edu	37	1	40928260	40928260	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:40928260C>T	ENST00000411995.2	+	6	979	c.604C>T	c.(604-606)Caa>Taa	p.Q202*	ZFP69B_ENST00000361584.3_Nonsense_Mutation_p.Q100*|ZFP69B_ENST00000484445.1_3'UTR	NM_023070.2	NP_075558.2			ZFP69 zinc finger protein B																		ACAAGAGAACCAAAGAATGGG	0.398000													52	118					0	0	0.003610	0	0
FAM83A	84985	broad.mit.edu	37	8	124195459	124195459	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:124195459G>A	ENST00000518448.1	+	2	2377	c.363G>A	c.(361-363)tgG>tgA	p.W121*	FAM83A_ENST00000546351.1_Nonsense_Mutation_p.W121*|FAM83A_ENST00000276699.6_Nonsense_Mutation_p.W121*|FAM83A_ENST00000318462.6_Nonsense_Mutation_p.W121*|FAM83A_ENST00000522648.1_Nonsense_Mutation_p.W121*|FAM83A_ENST00000536633.1_Nonsense_Mutation_p.W121*			Q86UY5	FA83A_HUMAN	family with sequence similarity 83, member A	121										breast(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(3)|ovary(3)|prostate(2)|skin(1)	17	Lung NSC(37;1.55e-09)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			TGCACAGCTGGGCCTCAGCTG	0.612000													27	119					0	0	0.001786	0	0
ECEL1	9427	broad.mit.edu	37	2	233350918	233350918	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:233350918G>A	ENST00000304546.1	-	2	656	c.446C>T	c.(445-447)aCc>aTc	p.T149I	ECEL1_ENST00000409941.1_Missense_Mutation_p.T149I	NM_004826.2	NP_004817.2	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	149					neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(8)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		GGCCGCGATGGTGCCATAGGT	0.726000													7	11					0	0	0.003080	0	0
ASCC3	10973	broad.mit.edu	37	6	101296463	101296463	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:101296463G>A	ENST00000369162.2	-	4	706	c.362C>T	c.(361-363)cCc>cTc	p.P121L	ASCC3_ENST00000522650.1_Missense_Mutation_p.P121L	NM_006828.2	NP_006819.2	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit 3	121					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(20)|liver(1)|lung(36)|ovary(6)|prostate(4)|skin(3)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	92		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		TGAAGGAAAGGGGCCAAACAT	0.408000													20	14					0	0	0.001216	0	0
MUC17	140453	broad.mit.edu	37	7	100686884	100686884	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:100686884C>T	ENST00000306151.4	+	3	12251	c.12187C>T	c.(12187-12189)Cca>Tca	p.P4063S		NM_001040105.1	NP_001035194.1	Q685J3	MUC17_HUMAN	mucin 17, cell surface associated	4063						extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			NS(3)|breast(14)|central_nervous_system(2)|cervix(2)|endometrium(27)|haematopoietic_and_lymphoid_tissue(2)|kidney(18)|large_intestine(28)|lung(179)|ovary(19)|pancreas(1)|prostate(13)|skin(26)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(4)	343	Lung NSC(181;0.136)|all_lung(186;0.182)					TCACACCATCCCACCTACATT	0.547000													34	44					0	0	0.003755	0	0
PCDHB16	57717	broad.mit.edu	37	5	140563511	140563511	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:140563511C>T	ENST00000361016.2	+	1	2532	c.1377C>T	c.(1375-1377)ttC>ttT	p.F459F		NM_020957.1	NP_066008.1	Q9NRJ7	PCDBG_HUMAN		459	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding	p.F459F(1)		breast(1)|endometrium(10)|kidney(3)|large_intestine(14)|lung(29)|ovary(5)|pancreas(2)|prostate(3)|skin(1)|urinary_tract(1)	69			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			ACACCCTGTTCGTCCGCGAGA	0.582000													61	112					0	0	0.003610	0	0
METTL2A	339175	broad.mit.edu	37	17	60503710	60503710	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:60503710C>T	ENST00000311506.5	+	3	289	c.253C>T	c.(253-255)Cac>Tac	p.H85Y		NM_181725.3	NP_859076.3	Q96IZ6	MTL2A_HUMAN	methyltransferase like 2A	85							methyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(1)|upper_aerodigestive_tract(2)	6			BRCA - Breast invasive adenocarcinoma(2;1.08e-10)			CTACAAAATCCACGAAAATGG	0.348000													11	47					0	0	0.001855	0	0
C12orf40	283461	broad.mit.edu	37	12	40041606	40041606	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:40041606G>A	ENST00000324616.5	+	6	551	c.397G>A	c.(397-399)Gac>Aac	p.D133N	C12orf40_ENST00000405531.3_Missense_Mutation_p.D133N|C12orf40_ENST00000398716.1_Missense_Mutation_p.D56N	NM_001031748.2	NP_001026918.2	Q86WS4	CL040_HUMAN	chromosome 12 open reading frame 40	133										breast(4)|central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(14)|ovary(6)|prostate(1)|skin(2)	38						ACAAGGCATGGACTCATATAG	0.328000													10	33					0	0	0.001368	0	0
LIMK2	3985	broad.mit.edu	37	22	31662023	31662023	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:31662023C>T	ENST00000331728.4	+	8	1060	c.946C>T	c.(946-948)Cgt>Tgt	p.R316C	LIMK2_ENST00000340552.4_Missense_Mutation_p.R295C|LIMK2_ENST00000406516.1_Missense_Mutation_p.R238C|LIMK2_ENST00000444929.2_Missense_Mutation_p.R70C|LIMK2_ENST00000333611.4_Missense_Mutation_p.R295C	NM_005569.3	NP_005560.1	P53671	LIMK2_HUMAN	LIM domain kinase 2	316						mitochondrion|nucleus	ATP binding|protein serine/threonine kinase activity|zinc ion binding			endometrium(7)|kidney(3)|large_intestine(6)|lung(6)|ovary(2)|prostate(4)|skin(1)	29						AGAATCCCTTCGTTGTTCCAG	0.577000													34	35					0	0	0.004289	0	0
CYP11B2	1585	broad.mit.edu	37	8	143999085	143999085	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:143999085C>T	ENST00000323110.2	-	1	174	c.172G>A	c.(172-174)Gag>Aag	p.E58K		NM_000498.3	NP_000489.3	P19099	C11B2_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 2	58					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|potassium ion homeostasis|regulation of blood volume by renal aldosterone|sodium ion homeostasis|xenobiotic metabolic process		corticosterone 18-monooxygenase activity|electron carrier activity|steroid 11-beta-monooxygenase activity			cervix(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(22)|ovary(3)|upper_aerodigestive_tract(3)	39	all_cancers(97;5.56e-11)|all_epithelial(106;2.49e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Candesartan(DB00796)|Metyrapone(DB01011)	TAACCCTGCTCCCTCCAGATC	0.637000									Familial Hyperaldosteronism type I				40	82					0	0	0.005524	0	0
NAT10	55226	broad.mit.edu	37	11	34135386	34135386	+	Splice_Site	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:34135386G>A	ENST00000257829.3	+	5	701		c.e5+1		NAT10_ENST00000531159.2_Splice_Site|NAT10_ENST00000527971.1_Splice_Site	NM_024662.2	NP_078938.2	Q9H0A0	NAT10_HUMAN	N-acetyltransferase 10 (GCN5-related)							nucleolus	ATP binding|N-acetyltransferase activity|protein binding			endometrium(4)|large_intestine(8)|lung(8)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	23		Acute lymphoblastic leukemia(5;0.0119)|all_hematologic(20;0.0231)				AGTGACTATGGTAAGCATCTG	0.443000													57	24					0	0	0.003610	0	0
ZKSCAN1	7586	broad.mit.edu	37	7	99627572	99627572	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:99627572C>T	ENST00000324306.6	+	4	903	c.669C>T	c.(667-669)tcC>tcT	p.S223S	ZKSCAN1_ENST00000535170.1_Silent_p.S10S|ZKSCAN1_ENST00000426572.1_Silent_p.S187S	NM_003439.1	NP_003430.1	P17029	ZKSC1_HUMAN	zinc finger with KRAB and SCAN domains 1	223					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|lung(5)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	25	Lung NSC(181;0.0211)|all_lung(186;0.0323)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			CAGCGGATTCCCAGGTGAGCT	0.597000													13	20					0	0	0.001855	0	0
CTD-3074O7.11	0	broad.mit.edu	37	11	66298428	66298428	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:66298428C>T	ENST00000419755.3	+	15	1726	c.1648C>T	c.(1648-1650)Cct>Tct	p.P550S	ZDHHC24_ENST00000526986.1_Intron|BBS1_ENST00000455748.2_Missense_Mutation_p.P416S|BBS1_ENST00000393994.2_Missense_Mutation_p.P384S|BBS1_ENST00000318312.7_Missense_Mutation_p.P513S																							AACAACCCGTCCTGTCCTGGG	0.567000													22	54					0	0	0.002299	0	0
PCNT	5116	broad.mit.edu	37	21	47864622	47864622	+	Silent	SNP	A	A	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:47864622A>G	ENST00000359568.5	+	46	9962	c.9855A>G	c.(9853-9855)ccA>ccG	p.P3285P	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	3285					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					CTCCATCCCCAAATTCAAGAT	0.403000													16	26					0	0	0.004990	0	0
DNER	92737	broad.mit.edu	37	2	230253045	230253045	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:230253045C>T	ENST00000341772.4	-	11	1925	c.1791G>A	c.(1789-1791)ctG>ctA	p.L597L		NM_139072.3	NP_620711.3	Q8NFT8	DNER_HUMAN	delta/notch-like EGF repeat containing	597	EGF-like 10; calcium-binding (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			NS(2)|breast(1)|endometrium(7)|kidney(1)|large_intestine(13)|liver(1)|lung(28)|ovary(2)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	63		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TGGGCTGGTCCAGGCAGCTCC	0.498000													49	76					0	0	0.003610	0	0
DNAH17	8632	broad.mit.edu	37	17	76457737	76457737	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:76457737C>T	ENST00000389840.5	-	58	9310	c.9186G>A	c.(9184-9186)aaG>aaA	p.K3062K	DNAH17_ENST00000585328.1_Silent_p.K3071K|DNAH17_ENST00000586052.1_5'UTR					dynein, axonemal, heavy chain 17											NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			CGCTCTCATTCTTCTGCTTGA	0.557000													8	14					0	0	0.003080	0	0
PTPRB	5787	broad.mit.edu	37	12	70953240	70953240	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:70953240C>T	ENST00000334414.6	-	18	4641	c.4597G>A	c.(4597-4599)Gaa>Aaa	p.E1533K	PTPRB_ENST00000551525.1_Missense_Mutation_p.E1532K|PTPRB_ENST00000550857.1_Missense_Mutation_p.E1225K|PTPRB_ENST00000538708.1_Missense_Mutation_p.E1225K|PTPRB_ENST00000261266.5_Missense_Mutation_p.E1315K|PTPRB_ENST00000550358.1_Missense_Mutation_p.E1445K|PTPRB_ENST00000451516.2_Missense_Mutation_p.E1225K	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1315	Fibronectin type-III 17.				angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ATGCGTCCTTCTGATTTTCTG	0.468000													62	170					0	0	0.003610	0	0
FHOD1	29109	broad.mit.edu	37	16	67281298	67281298	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:67281298C>T	ENST00000258201.4	-	1	263	c.16G>A	c.(16-18)Gac>Aac	p.D6N	FHOD1_ENST00000567687.1_Missense_Mutation_p.D6N	NM_013241.2	NP_037373.2	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	6					actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(4)|endometrium(3)|kidney(3)|large_intestine(5)|lung(7)|ovary(3)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	34		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		TCCCCGCGGTCTTCCCCGCCC	0.677000													7	12					0	0	0.001984	0	0
GSS	2937	broad.mit.edu	37	20	33519905	33519905	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:33519905G>A	ENST00000216951.2	-	10	964	c.866C>T	c.(865-867)tCa>tTa	p.S289L	GSS_ENST00000451957.2_Missense_Mutation_p.S178L|GSS_ENST00000541098.1_Missense_Mutation_p.S161L	NM_000178.2	NP_000169.1	P48637	GSHB_HUMAN	glutathione synthetase	289					nervous system development|response to oxidative stress|xenobiotic metabolic process	cytosol	ATP binding|glutathione binding|glutathione synthase activity|magnesium ion binding|protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)	17			BRCA - Breast invasive adenocarcinoma(18;0.035)		Glutathione(DB00143)|Glycine(DB00145)|L-Cysteine(DB00151)	GGCAGCATGTGACCTCTCCAG	0.517000													30	117					0	0	0.003755	0	0
CCL15	6359	broad.mit.edu	37	17	34324841	34324841	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:34324841G>A	ENST00000354059.4	-	4	856	c.304C>T	c.(304-306)Cag>Tag	p.Q102*	CCL14_ENST00000536149.1_5'UTR|CCL15-CCL14_ENST00000481427.2_Nonsense_Mutation_p.Q102*	NM_032965.4	NP_116741.1	Q16663	CCL15_HUMAN	chemokine (C-C motif) ligand 15	102					cell-cell signaling|cellular calcium ion homeostasis|immune response	extracellular space	chemoattractant activity|chemokine activity|heparin binding|signal transducer activity			large_intestine(2)|lung(4)|ovary(1)|urinary_tract(1)	8		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ATGCAATCCTGAACTCCCGGA	0.498000													15	17					0	0	0.004990	0	0
DSC1	1823	broad.mit.edu	37	18	28719835	28719835	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:28719835A>C	ENST00000257197.3	-	11	1800	c.1539T>G	c.(1537-1539)gaT>gaG	p.D513E	DSC1_ENST00000257198.5_Missense_Mutation_p.D513E|RP11-408H20.2_ENST00000581836.1_RNA	NM_004948.3	NP_004939.1	Q08554	DSC1_HUMAN	desmocollin 1	513	Cadherin 4.				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(20)|ovary(3)|skin(10)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	53			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			AGTTATCTTCATCCCCTAACT	0.299000													12	23					0	0	0.002450	0	0
TOX	9760	broad.mit.edu	37	8	59720828	59720828	+	Splice_Site	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:59720828C>T	ENST00000361421.1	-	8	1613	c.1392_splice	c.e8-1	p.G465_splice		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	465						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				AGAGTAAATCCCTGAAAGGGA	0.418000											OREG0018787	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	18	74					0	0	0.007413	0	0
SPTBN1	6711	broad.mit.edu	37	2	54858354	54858354	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:54858354C>T	ENST00000333896.5	+	15	3516	c.3131C>T	c.(3130-3132)tCc>tTc	p.S1044F	SPTBN1_ENST00000356805.4_Missense_Mutation_p.S1057F	NM_178313.2	NP_842565.2	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1	1057					actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			NS(1)|breast(8)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(11)|lung(27)|ovary(4)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	82			Lung(47;0.24)			CGAGAGGCCTCCCTGGGAGAG	0.632000													20	48					0	0	0.001523	0	0
SHANK2	22941	broad.mit.edu	37	11	70333519	70333519	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:70333519G>A	ENST00000338508.4	-	32	2881	c.2882C>T	c.(2881-2883)tCc>tTc	p.S961F	SHANK2_ENST00000449833.2_Missense_Mutation_p.S365F|SHANK2_ENST00000423696.2_Missense_Mutation_p.S581F|SHANK2_ENST00000409161.1_Missense_Mutation_p.S364F			Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	581					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(30)|ovary(3)|pancreas(2)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			AGAGTCCAAGGAGTAGCGGTC	0.592000													17	219					0	0	0.004990	0	0
C2orf16	84226	broad.mit.edu	37	2	27800886	27800886	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:27800886G>A	ENST00000408964.2	+	1	1498	c.1447G>A	c.(1447-1449)Gat>Aat	p.D483N		NM_032266.3	NP_115642.3	Q68DN1	CB016_HUMAN	chromosome 2 open reading frame 16	483								p.D483H(2)		breast(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(33)|urinary_tract(1)	47	Acute lymphoblastic leukemia(172;0.155)					AGAGCCACTAGATCAAGTCAC	0.423000													18	46					0	0	0.004990	0	0
MIR568	693153	broad.mit.edu	37	3	114035333	114035333	+	RNA	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:114035333C>T	ENST00000385036.1	-	0	83					NR_030293.1																						atatacacacctatacatgta	0.303000													5	11					0	0	0.000602	0	0
DNAH11	8701	broad.mit.edu	37	7	21657364	21657364	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:21657364G>A	ENST00000328843.6	+	23	4269	c.4238G>A	c.(4237-4239)aGg>aAg	p.R1413K	DNAH11_ENST00000409508.3_Missense_Mutation_p.R1408K			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1413	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						CTCAGGGACAGGCATTGGCAC	0.512000									Kartagener syndrome				15	31					0	0	0.003163	0	0
IL36B	27177	broad.mit.edu	37	2	113786623	113786623	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:113786623C>T	ENST00000259213.4	-	4	261	c.154G>A	c.(154-156)Gaa>Aaa	p.E52K	IL36B_ENST00000327407.2_Missense_Mutation_p.E52K	NM_014438.3	NP_055253.2	Q9NZH7	IL36B_HUMAN	interleukin 36, beta	52					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			kidney(1)|ovary(1)|pancreas(1)	3						TCACTGAATTCTGTGTCTCTA	0.428000													26	32					0	0	0.005443	0	0
RANBP2	5903	broad.mit.edu	37	2	109383770	109383770	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:109383770C>T	ENST00000283195.6	+	20	6901	c.6775C>T	c.(6775-6777)Cgt>Tgt	p.R2259C		NM_006267.4	NP_006258.3	P49792	RBP2_HUMAN	RAN binding protein 2	2259					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(34)	NS(1)|biliary_tract(1)|breast(3)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(21)|large_intestine(19)|lung(51)|pancreas(1)|prostate(8)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	129						AAATCTTTTCCGTTTTGGTGA	0.403000													113	160					0	0	0.003610	0	0
ZNF197	10168	broad.mit.edu	37	3	44683587	44683587	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:44683587A>C	ENST00000396058.1	+	5	1132	c.965A>C	c.(964-966)aAg>aCg	p.K322T	ZNF197_ENST00000383745.2_Intron|ZNF197_ENST00000383744.4_Intron|RP11-944L7.4_ENST00000457331.1_RNA|ZNF197_ENST00000344387.4_Missense_Mutation_p.K322T			O14709	ZN197_HUMAN	zinc finger protein 197	322					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(1)|skin(1)	25				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		GATACAGTGAAGAAAGTTTCC	0.443000													15	28					0	0	0.003163	0	0
GALNT16	57452	broad.mit.edu	37	14	69800304	69800304	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:69800304G>A	ENST00000337827.4	+	9	1281	c.954G>A	c.(952-954)ggG>ggA	p.G318G	GALNT16_ENST00000448469.3_Silent_p.G318G|GALNT16_ENST00000553669.1_Silent_p.G318G	NM_001168368.1|NM_020692.2	NP_001161840.1|NP_065743.2			UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 16																		ACATCTGGGGGGGAGAGAATT	0.473000													25	29					0	0	0.007291	0	0
NMU	10874	broad.mit.edu	37	4	56466727	56466727	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:56466727G>A	ENST00000264218.3	-	8	556	c.451C>T	c.(451-453)Ccc>Tcc	p.P151S	NMU_ENST00000511469.1_Missense_Mutation_p.P135S|NMU_ENST00000507338.1_Missense_Mutation_p.P126S|NMU_ENST00000505262.1_Missense_Mutation_p.P124S|NMU_ENST00000515325.1_5'UTR	NM_006681.2	NP_006672.1	P48645	NMU_HUMAN	neuromedin U	151					neuropeptide signaling pathway	extracellular region				lung(3)|ovary(1)|urinary_tract(1)	5	Lung NSC(11;0.00256)|all_epithelial(27;0.075)|Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.103)	LUSC - Lung squamous cell carcinoma(4;6.72e-08)|Lung(4;6.22e-07)|Epithelial(7;0.00559)	LUSC - Lung squamous cell carcinoma(721;0.0115)		CTTGCAAAGGGACTTTGGAAT	0.313000													21	44					0	0	0.001882	0	0
PCLO	27445	broad.mit.edu	37	7	82763746	82763746	+	Silent	SNP	A	A	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:82763746A>T	ENST00000423517.2	-	3	3457	c.3120T>A	c.(3118-3120)ccT>ccA	p.P1040P	PCLO_ENST00000333891.8_Silent_p.P1040P	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	986					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CAGCCTTTTGAGGCTCAGCTG	0.423000													12	16					0	0	0.001855	0	0
EHMT2	10919	broad.mit.edu	37	6	31860665	31860665	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:31860665G>A	ENST00000395728.3	-	4	775	c.776C>T	c.(775-777)cCc>cTc	p.P259L	EHMT2_ENST00000375528.4_Missense_Mutation_p.P259L|EHMT2_ENST00000480912.1_5'UTR|EHMT2_ENST00000375537.4_Missense_Mutation_p.P202L|EHMT2_ENST00000375530.4_Missense_Mutation_p.P202L			Q96KQ7	EHMT2_HUMAN	euchromatic histone-lysine N-methyltransferase 2	202					DNA methylation|peptidyl-lysine dimethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			central_nervous_system(1)|cervix(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	21						TATTTCAGGGGGCCGCTTCTC	0.617000													96	809					0	0	0.003610	0	0
HIST1H4I	8294	broad.mit.edu	37	6	27107257	27107257	+	Missense_Mutation	SNP	G	G	A	rs140361782		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:27107257G>A	ENST00000354348.2	+	1	182	c.170G>A	c.(169-171)gGa>gAa	p.G57E	HIST1H2BK_ENST00000396891.4_Intron	NM_003495.2	NP_003486.1	P62805	H4_HUMAN	histone cluster 1, H4i	57					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			lung(1)	1						GAGACCCGCGGAGTGTTGAAG	0.632000			T	BCL6	NHL								15	64					0	0	0.003163	0	0
ZFHX4	79776	broad.mit.edu	37	8	77765793	77765793	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:77765793C>T	ENST00000521891.2	+	10	7084	c.6636C>T	c.(6634-6636)ccC>ccT	p.P2212P	ZFHX4_ENST00000050961.6_Silent_p.P2167P|ZFHX4_ENST00000455469.2_Silent_p.P2167P|ZFHX4_ENST00000518282.1_Silent_p.P2186P	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2167						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATCCACAGCCCACCTCTTTAG	0.373000										HNSCC(33;0.089)			31	132					0	0	0.001786	0	0
ACAN	176	broad.mit.edu	37	15	89398703	89398703	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr15:89398703C>T	ENST00000439576.2	+	12	3261	c.2887C>T	c.(2887-2889)Cta>Tta	p.L963L	ACAN_ENST00000559004.1_Silent_p.L963L|ACAN_ENST00000352105.7_Silent_p.L963L|ACAN_ENST00000561243.1_Silent_p.L963L	NM_013227.3	NP_037359.3	E7EX88	E7EX88_HUMAN	aggrecan	963					cell adhesion		hyaluronic acid binding|sugar binding			NS(1)|central_nervous_system(4)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(15)|liver(2)|lung(40)|ovary(2)|prostate(5)|skin(5)|stomach(8)|upper_aerodigestive_tract(1)|urinary_tract(2)	93	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			TGGAGAAGTTCTAGAGACCTC	0.567000													28	45					0	0	0.005443	0	0
TRIM38	10475	broad.mit.edu	37	6	25983665	25983665	+	Missense_Mutation	SNP	G	G	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:25983665G>T	ENST00000357085.3	+	8	1624	c.1148G>T	c.(1147-1149)tGg>tTg	p.W383L	TRIM38_ENST00000349458.3_Missense_Mutation_p.W383L	NM_006355.3	NP_006346.1	O00635	TRI38_HUMAN	tripartite motif containing 38	383	B30.2/SPRY.				positive regulation of I-kappaB kinase/NF-kappaB cascade	intracellular	signal transducer activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(8)|upper_aerodigestive_tract(2)	23						TCTGGATTCTGGACCCTCAGG	0.502000													6	153					0.00116845	0.00197332	0.001168	1	0
OXCT2	64064	broad.mit.edu	37	1	40236126	40236126	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:40236126G>A	ENST00000327582.5	-	1	894	c.802C>T	c.(802-804)Cgc>Tgc	p.R268C	BMP8B_ENST00000397360.2_Intron|BMP8B_ENST00000372827.3_Intron	NM_022120.1	NP_071403.1	Q9BYC2	SCOT2_HUMAN	3-oxoacid CoA transferase 2	268					ketone body catabolic process	microtubule-based flagellum|mitochondrion	3-oxoacid CoA-transferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|pancreas(1)|upper_aerodigestive_tract(1)	6	all_cancers(7;5.56e-14)|all_lung(5;3.88e-17)|all_epithelial(6;3.78e-16)|Lung NSC(20;7.03e-07)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;1.87e-18)|Epithelial(16;1.92e-17)|all cancers(16;4.03e-16)|LUSC - Lung squamous cell carcinoma(16;0.000261)|Lung(16;0.000457)		Succinic acid(DB00139)	TTTATCACGCGATCTACATAA	0.537000											OREG0013400	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	31	70					0	0	0.002836	0	0
ZC3H3	23144	broad.mit.edu	37	8	144557690	144557690	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:144557690G>A	ENST00000262577.5	-	5	1812	c.1781C>T	c.(1780-1782)cCt>cTt	p.P594L		NM_015117.2	NP_055932.2	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	594					mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			CCGCCACCAAGGGGAGCCCGG	0.642000													9	25					0	0	0.004482	0	0
KCNB1	3745	broad.mit.edu	37	20	47989747	47989747	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:47989747G>A	ENST00000371741.4	-	2	2516	c.2350C>T	c.(2350-2352)Ccg>Tcg	p.P784S		NM_004975.2	NP_004966.1	Q14721	KCNB1_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 1	784					energy reserve metabolic process|regulation of insulin secretion	voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|liver(1)|lung(22)|pancreas(2)|prostate(7)|skin(4)|stomach(1)|urinary_tract(1)	53			BRCA - Breast invasive adenocarcinoma(12;0.000405)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			CTGAACTTCGGACTGGTGCTC	0.537000													112	290					0	0	0.003610	0	0
BPIFB4	149954	broad.mit.edu	37	20	31671494	31671494	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:31671494G>A	ENST00000375483.3	+	3	491	c.491G>A	c.(490-492)gGg>gAg	p.G164E		NM_182519.2	NP_872325.2	P59827	LPLC4_HUMAN	BPI fold containing family B, member 4	164	Gly-rich.					cytoplasm|extracellular region	lipid binding										GTTGCCACTGGGGCGGTGGGC	0.677000													20	59					0	0	0.001216	0	0
FZD10	11211	broad.mit.edu	37	12	130648609	130648609	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:130648609G>A	ENST00000539839.1	+	1	1606	c.1024G>A	c.(1024-1026)Ggt>Agt	p.G342S	FZD10_ENST00000229030.4_Silent_p.R374R	NM_007197.3	NP_009128.1	Q9ULW2	FZD10_HUMAN	frizzled family receptor 10	0					brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|pancreas(1)|prostate(3)|urinary_tract(1)	35	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		TCATGCGCAGGGTGGCGGGGG	0.657000													9	31					0	0	0.001368	0	0
PPL	5493	broad.mit.edu	37	16	4941922	4941922	+	Missense_Mutation	SNP	T	T	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:4941922T>G	ENST00000345988.2	-	16	1947	c.1858A>C	c.(1858-1860)Agc>Cgc	p.S620R	PPL_ENST00000590782.2_Missense_Mutation_p.S618R	NM_002705.4	NP_002696.3	O60437	PEPL_HUMAN	periplakin	620					keratinization	cytoskeleton|desmosome|mitochondrion|nucleus	protein binding|structural constituent of cytoskeleton			breast(6)|central_nervous_system(1)|endometrium(11)|kidney(5)|large_intestine(12)|lung(12)|ovary(4)|prostate(5)|skin(3)|stomach(1)|urinary_tract(2)	62						TGCTGCAGGCTCTTCTCCAGG	0.627000													34	50					0	0	0.004289	0	0
OPN4	94233	broad.mit.edu	37	10	88416026	88416026	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:88416026G>A	ENST00000372071.2	+	2	486	c.259G>A	c.(259-261)Ggc>Agc	p.G87S	OPN4_ENST00000241891.5_Missense_Mutation_p.G87S	NM_001030015.2	NP_001025186.1	Q9UHM6	OPN4_HUMAN	opsin 4	87					phototransduction|protein-chromophore linkage|regulation of circadian rhythm|rhythmic process|visual perception	integral to membrane|plasma membrane	11-cis retinal binding|G-protein coupled photoreceptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(2)|liver(2)|lung(5)|ovary(3)	18						GGGGATGCTGGGCAACCTGAC	0.612000													33	51					0	0	0.004878	0	0
MUC16	94025	broad.mit.edu	37	19	9068506	9068506	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:9068506C>T	ENST00000397910.4	-	3	19143	c.18940G>A	c.(18940-18942)Gaa>Aaa	p.E6314K		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	6316	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						AAATAGAATTCATTTGGTGAA	0.463000													21	57					0	0	0.001882	0	0
SDK1	221935	broad.mit.edu	37	7	4185409	4185409	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:4185409G>A	ENST00000404826.2	+	29	4423	c.4284G>A	c.(4282-4284)gtG>gtA	p.V1428V	SDK1_ENST00000389531.3_Silent_p.V1428V	NM_152744.3	NP_689957.3	Q7Z5N4	SDK1_HUMAN	sidekick cell adhesion molecule 1	1428	Fibronectin type-III 8.				cell adhesion	integral to membrane				NS(1)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(42)|lung(55)|ovary(4)|pancreas(1)|prostate(4)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(4)	153		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		TCACCACCGTGGAGGTCGGCG	0.662000													25	193					0	0	0.005443	0	0
FOLH1	2346	broad.mit.edu	37	11	49168382	49168382	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:49168382C>G	ENST00000340334.7	-	20	2502	c.2134G>C	c.(2134-2136)Gaa>Caa	p.E712Q	FOLH1_ENST00000343844.4_Missense_Mutation_p.E419Q|FOLH1_ENST00000256999.2_Missense_Mutation_p.E727Q|FOLH1_ENST00000356696.3_Missense_Mutation_p.E696Q|FOLH1_ENST00000533034.1_Missense_Mutation_p.E681Q	NM_001193471.1|NM_001193472.1	NP_001180400.1|NP_001180401.1	Q04609	FOLH1_HUMAN	folate hydrolase (prostate-specific membrane antigen) 1	727					proteolysis	cytoplasm|integral to plasma membrane|membrane fraction|nucleus	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity			NS(2)|breast(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(7)|lung(34)|ovary(1)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(3)	60					Capromab(DB00089)|L-Glutamic Acid(DB00142)	CTCTTCACTTCTCCCCAGGCC	0.463000													32	41					0	0	0.001512	0	0
NAE1	8883	broad.mit.edu	37	16	66844305	66844305	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:66844305G>A	ENST00000379463.2	-	16	1296	c.1104C>T	c.(1102-1104)tcC>tcT	p.S368S	NAE1_ENST00000394074.2_Silent_p.S285S|NAE1_ENST00000359087.4_Silent_p.S377S|NAE1_ENST00000290810.3_Silent_p.S374S	NM_001018159.1	NP_001018169.1	Q13564	ULA1_HUMAN	NEDD8 activating enzyme E1 subunit 1	374					apoptosis|cell cycle|DNA replication|mitotic cell cycle DNA replication checkpoint|protein neddylation|signal transduction	cytoplasm|insoluble fraction|plasma membrane	catalytic activity|protein heterodimerization activity			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0914)|Epithelial(162;0.214)	Adenosine triphosphate(DB00171)	TCTCTGAAATGGACTCTGGTG	0.378000													33	63					0	0	0.006230	0	0
TP63	8626	broad.mit.edu	37	3	189455616	189455616	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:189455616C>T	ENST00000264731.3	+	2	239	c.150C>T	c.(148-150)ctC>ctT	p.L50L	TP63_ENST00000320472.5_Silent_p.L50L|TP63_ENST00000392460.3_Silent_p.L50L|TP63_ENST00000440651.2_Silent_p.L50L|TP63_ENST00000382063.4_Silent_p.L50L|TP63_ENST00000418709.2_Silent_p.L50L	NM_001114978.1|NM_003722.4	NP_001108450.1|NP_003713.3	Q9H3D4	P63_HUMAN	tumor protein p63	50	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|kidney(5)|large_intestine(12)|lung(15)|ovary(2)|skin(9)|upper_aerodigestive_tract(6)	61	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ATGAATTCCTCAGTCCAGAGG	0.398000										HNSCC(45;0.13)			16	42					0	0	0.004007	0	0
ELMO2	63916	broad.mit.edu	37	20	44999142	44999142	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:44999142G>A	ENST00000372176.1	-	20	2028	c.1560C>T	c.(1558-1560)gcC>gcT	p.A520A	ELMO2_ENST00000439931.2_Silent_p.A620A|ELMO2_ENST00000445496.2_Silent_p.A425A|ELMO2_ENST00000454865.2_Silent_p.A340A|ELMO2_ENST00000290246.6_Silent_p.A608A|ELMO2_ENST00000396391.1_Silent_p.A608A|ELMO2_ENST00000352077.2_Silent_p.A606A			Q96JJ3	ELMO2_HUMAN	engulfment and cell motility 2	608					apoptosis|cell chemotaxis|phagocytosis	cytoskeleton|cytosol|membrane	lyase activity|receptor tyrosine kinase binding|SH3 domain binding			breast(1)|endometrium(1)|large_intestine(4)|lung(8)|ovary(1)|urinary_tract(1)	16		Myeloproliferative disorder(115;0.0122)				CAGTGACAATGGCCTTAATGT	0.473000													27	87					0	0	0.002836	0	0
HSD3B2	3284	broad.mit.edu	37	1	119964532	119964532	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:119964532C>T	ENST00000543831.1	+	4	657	c.408C>T	c.(406-408)atC>atT	p.I136I	HSD3B2_ENST00000369416.3_Silent_p.I136I	NM_001166120.1	NP_001159592.1	P26439	3BHS2_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	136					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(19)|ovary(2)|skin(1)	27	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	ACAAGGAAATCATCCAGAACG	0.542000													35	89					0	0	0.002836	0	0
KIR3DL2	3812	broad.mit.edu	37	19	55378000	55378000	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55378000G>A	ENST00000326321.3	+	9	1215	c.1182G>A	c.(1180-1182)caG>caA	p.Q394Q	KIR3DL2_ENST00000270442.5_Silent_p.Q377Q|KIR3DL1_ENST00000402254.2_Silent_p.Q394Q	NM_006737.3	NP_006728.2	P43630	KI3L2_HUMAN	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2	394					cellular defense response|regulation of immune response	integral to plasma membrane	receptor activity			breast(1)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	23				GBM - Glioblastoma multiforme(193;0.0192)		AAGACCCTCAGGAGGTGACGT	0.498000													105	214					0	0	0.003610	0	0
DNAAF3	352909	broad.mit.edu	37	19	55670904	55670904	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:55670904G>A	ENST00000527223.2	-	11	1437	c.1436C>T	c.(1435-1437)gCc>gTc	p.A479V	DNAAF3_ENST00000391720.4_Missense_Mutation_p.A459V|DNAAF3_ENST00000455045.1_Missense_Mutation_p.A358V|CTD-2587H24.4_ENST00000587871.1_Silent_p.S73S|DNAAF3_ENST00000524407.2_Missense_Mutation_p.A412V|DNAAF3_ENST00000587789.2_5'UTR|CTD-2587H24.5_ENST00000591665.1_RNA	NM_001256714.1	NP_001243643.1	Q8N9W5	CS051_HUMAN	dynein, axonemal, assembly factor 3	412																	GACTCACCGGGCTAATTCCAC	0.597000													41	115					0	0	0.003610	0	0
CA10	56934	broad.mit.edu	37	17	50008441	50008441	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:50008441C>T	ENST00000451037.2	-	3	1128	c.188G>A	c.(187-189)gGg>gAg	p.G63E	CA10_ENST00000570565.1_5'UTR|CA10_ENST00000285273.4_Missense_Mutation_p.G63E|CA10_ENST00000442502.2_Missense_Mutation_p.G63E|CA10_ENST00000340813.6_Missense_Mutation_p.G69E	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	63					brain development					cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			CTGCCGTTTCCCCACAGAGCA	0.488000													49	253					0	0	0.003610	0	0
OR10H5	284433	broad.mit.edu	37	19	15905792	15905792	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:15905792C>T	ENST00000308940.8	+	1	1032	c.934C>T	c.(934-936)Cca>Tca	p.P312S		NM_001004466.1	NP_001004466.1	Q8NGA6	O10H5_HUMAN	olfactory receptor, family 10, subfamily H, member 5	312					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(3)|liver(1)|lung(9)|ovary(1)	20						CAAACTCTTTCCACAGAACTG	0.488000													10	9					0	0	0.000673	0	0
OGFR	11054	broad.mit.edu	37	20	61444274	61444274	+	Missense_Mutation	SNP	C	C	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:61444274C>A	ENST00000370461.1	+	5	3428	c.1151C>A	c.(1150-1152)cCt>cAt	p.P384H	OGFR_ENST00000290291.6_Missense_Mutation_p.P436H|OGFR_ENST00000370468.3_Missense_Mutation_p.P436H			Q9NZT2	OGFR_HUMAN	opioid growth factor receptor	436					regulation of cell growth	cytoplasm|membrane|nucleus	opioid receptor activity			endometrium(2)|kidney(1)|lung(4)|prostate(3)|skin(4)|upper_aerodigestive_tract(3)	17	Breast(26;3.65e-08)					GGTCAGGACCCTGGGGAGGCA	0.662000													17	26					0.00498961	0.00841943	0.004990	1	0
INTS3	65123	broad.mit.edu	37	1	153721217	153721217	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:153721217C>T	ENST00000318967.2	+	6	1138	c.570C>T	c.(568-570)atC>atT	p.I190I	INTS3_ENST00000456435.1_5'UTR|RP11-216N14.8_ENST00000453778.1_RNA|INTS3_ENST00000435409.2_Silent_p.I190I	NM_023015.3	NP_075391.3	Q68E01	INT3_HUMAN	integrator complex subunit 3	191					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			breast(1)|cervix(4)|endometrium(10)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TTCTGGATATCCTGACAGAGC	0.468000													82	240					0	0	0.003610	0	0
BAI2	576	broad.mit.edu	37	1	32204490	32204490	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:32204490G>A	ENST00000373658.3	-	16	2885	c.2544C>T	c.(2542-2544)ccC>ccT	p.P848P	BAI2_ENST00000398547.1_Silent_p.P781P|BAI2_ENST00000527361.1_Silent_p.P848P|BAI2_ENST00000398542.1_Silent_p.P781P|BAI2_ENST00000373655.2_Silent_p.P848P|BAI2_ENST00000257070.4_Silent_p.P848P|BAI2_ENST00000398556.3_Silent_p.P796P|BAI2_ENST00000440175.2_Silent_p.P490P|BAI2_ENST00000398538.1_Silent_p.P836P	NM_001703.2	NP_001694.2	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	848					negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			breast(5)|central_nervous_system(2)|endometrium(1)|large_intestine(7)|liver(2)|lung(24)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	55		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		GCTGGGTAGGGGGGCGCACAG	0.632000													22	108					0	0	0.006320	0	0
RAB27B	5874	broad.mit.edu	37	18	52556515	52556515	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:52556515C>T	ENST00000262094.5	+	6	1049	c.528C>T	c.(526-528)acC>acT	p.T176T	RP11-839G9.1_ENST00000588466.1_RNA	NM_004163.4	NP_004154.2	O00194	RB27B_HUMAN	RAB27B, member RAS oncogene family	176					protein transport|small GTPase mediated signal transduction	Golgi apparatus|plasma membrane	GTP binding|GTPase activity			large_intestine(3)|lung(3)|skin(1)	7				Colorectal(16;0.0273)|READ - Rectum adenocarcinoma(59;0.219)		CTGTAGAAACCCTTTTGGACT	0.403000													13	17					0	0	0.004007	0	0
RAVER1	125950	broad.mit.edu	37	19	10444151	10444151	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:10444151G>A	ENST00000293677.6	-	1	165	c.84C>T	c.(82-84)ccC>ccT	p.P28P		NM_133452.2	NP_597709.2	Q8IY67	RAVR1_HUMAN	ribonucleoprotein, PTB-binding 1	11						cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding			breast(1)|endometrium(3)|large_intestine(1)|lung(8)|ovary(2)|skin(1)|upper_aerodigestive_tract(2)	18			OV - Ovarian serous cystadenocarcinoma(20;1.81e-09)|Epithelial(33;3.65e-06)|all cancers(31;8.35e-06)			GGCTCAGCGGGGGCCGGTGAG	0.697000													17	22					0	0	0.006122	0	0
SMIM3	85027	broad.mit.edu	37	5	150158501	150158501	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:150158501C>T	ENST00000600109.1	+	1	635	c.370C>T	c.(370-372)Cca>Tca	p.P124S	SMIM3_ENST00000526627.1_5'UTR																							CATCCCTGACCCAGGAACTTT	0.662000													3	9					0	0	0.000248	0	0
ARHGAP31	57514	broad.mit.edu	37	3	119121239	119121239	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:119121239C>T	ENST00000264245.4	+	10	2172	c.1640C>T	c.(1639-1641)tCt>tTt	p.S547F		NM_020754.2	NP_065805.2	Q2M1Z3	RHG31_HUMAN	Rho GTPase activating protein 31	547					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			breast(5)|central_nervous_system(1)|cervix(1)|endometrium(10)|kidney(3)|large_intestine(11)|lung(29)|ovary(2)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	67						GCTGAGACTTCTGCAGGTAAG	0.473000													17	32					0	0	0.004990	0	0
CXorf58	254158	broad.mit.edu	37	X	23956695	23956695	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:23956695C>T	ENST00000379211.3	+	8	1366	c.817C>T	c.(817-819)Cgg>Tgg	p.R273W		NM_001169574.1|NM_152761.2	NP_001163045.1|NP_689974.2	Q96LI9	CX058_HUMAN	chromosome X open reading frame 58	273										breast(2)|endometrium(2)|kidney(1)|large_intestine(6)|lung(2)|prostate(1)	14						ACCTCTATATCGGCCCTACAA	0.333000													51	3					0	0	0.003610	0	0
KLHL24	54800	broad.mit.edu	37	3	183368597	183368597	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:183368597C>T	ENST00000454652.1	+	4	839	c.453C>T	c.(451-453)ctC>ctT	p.L151L	KLHL24_ENST00000242810.6_Silent_p.L151L|KLHL24_ENST00000476808.1_Silent_p.L151L			Q6TFL4	KLH24_HUMAN	kelch-like family member 24	151						axon|cytoplasm|perikaryon				NS(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(10)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			TTAGTGTTCTCCGTGATGCAT	0.403000													30	87					0	0	0.001512	0	0
ZNF382	84911	broad.mit.edu	37	19	37101557	37101557	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:37101557C>T	ENST00000435416.1	+	2	1640	c.145C>T	c.(145-147)Cac>Tac	p.H49Y	ZNF382_ENST00000439428.1_Missense_Mutation_p.H48Y|ZNF382_ENST00000292928.2_Missense_Mutation_p.H49Y|ZNF382_ENST00000423582.1_5'UTR			Q96SR6	ZN382_HUMAN	zinc finger protein 382	49	KRAB.|Mediates interaction with TRIM28 (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(12)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(4)	34	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			ATCAGGGTTTCACATGGCTAA	0.378000													17	61					0	0	0.001523	0	0
PRG4	10216	broad.mit.edu	37	1	186281959	186281959	+	Silent	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:186281959T>A	ENST00000445192.2	+	12	4095	c.4050T>A	c.(4048-4050)gtT>gtA	p.V1350V	PRG4_ENST00000367486.3_Silent_p.V1307V|PRG4_ENST00000367484.3_Silent_p.V879V|PRG4_ENST00000367485.4_Silent_p.V1257V|PRG4_ENST00000367483.4_Silent_p.V1309V	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	1350					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CAAATGTGGTTACCTCAGCTA	0.388000													32	76					0	0	0.002445	0	0
LRTM1	57408	broad.mit.edu	37	3	54958730	54958730	+	Missense_Mutation	SNP	G	G	A	rs142832767		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:54958730G>A	ENST00000273286.5	-	2	682	c.520C>T	c.(520-522)Ctt>Ttt	p.L174F	LRTM1_ENST00000493075.1_Missense_Mutation_p.L98F|CACNA2D3_ENST00000490478.1_Intron|CACNA2D3_ENST00000415676.2_Intron|CACNA2D3_ENST00000288197.5_Intron|CACNA2D3_ENST00000474759.1_Intron	NM_020678.2	NP_065729.1	Q9HBL6	LRTM1_HUMAN	leucine-rich repeats and transmembrane domains 1	174						integral to membrane				breast(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(4)	21				KIRC - Kidney renal clear cell carcinoma(284;0.00975)|Kidney(284;0.0112)|OV - Ovarian serous cystadenocarcinoma(275;0.0502)		AGAAGTAAAAGCCTCACACTG	0.463000													34	63					0	0	0.003755	0	0
CACNB2	783	broad.mit.edu	37	10	18690937	18690937	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:18690937G>A	ENST00000396576.2	+	2	634	c.133G>A	c.(133-135)Gag>Aag	p.E45K	CACNB2_ENST00000377315.4_Missense_Mutation_p.E52K|CACNB2_ENST00000377319.3_Missense_Mutation_p.E45K|CACNB2_ENST00000377331.2_Missense_Mutation_p.E72K|CACNB2_ENST00000324631.7_Missense_Mutation_p.E100K|CACNB2_ENST00000377329.4_Missense_Mutation_p.E46K|CACNB2_ENST00000282343.8_Missense_Mutation_p.E72K|CACNB2_ENST00000352115.6_Missense_Mutation_p.E100K|CACNB2_ENST00000377328.1_Missense_Mutation_p.E100K	NM_000724.3	NP_000715.2	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2 subunit	100					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity	p.E100K(1)|p.E45K(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(12)|prostate(1)|skin(3)|stomach(2)	31					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CAGAGAAGCGGAGCGGCAGGC	0.552000													10	29					0	0	0.000673	0	0
FAT4	79633	broad.mit.edu	37	4	126371652	126371652	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:126371652G>A	ENST00000394329.3	+	9	9494	c.9481G>A	c.(9481-9483)Gaa>Aaa	p.E3161K	FAT4_ENST00000335110.5_Missense_Mutation_p.E1459K	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	3161	Cadherin 30.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CCAGAAACACGAAATGACGAT	0.378000													22	31					0	0	0.003954	0	0
SFTPD	6441	broad.mit.edu	37	10	81697941	81697941	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:81697941G>A	ENST00000372292.3	-	8	835	c.795C>T	c.(793-795)ttC>ttT	p.F265F		NM_003019.4	NP_003010.4	P35247	SFTPD_HUMAN	surfactant protein D	265	C-type lectin.				cell junction assembly|innate immune response|lung alveolus development|macrophage chemotaxis|negative regulation of interleukin-2 biosynthetic process|negative regulation of T cell proliferation|positive regulation of phagocytosis|reactive oxygen species metabolic process|receptor-mediated endocytosis|respiratory gaseous exchange|surfactant homeostasis	collagen|endocytic vesicle|extracellular space|lysosome	bacterial cell surface binding|protein binding|sugar binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(3)|skin(4)|urinary_tract(1)	17	Breast(12;0.000615)|Prostate(51;0.0095)|all_epithelial(25;0.027)		Epithelial(14;0.0244)|all cancers(16;0.0558)|Colorectal(32;0.109)			CTGCTGTCTTGAAAATCTTCT	0.542000													20	36					0	0	0.001523	0	0
MOV10L1	54456	broad.mit.edu	37	22	50580554	50580554	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:50580554G>A	ENST00000262794.5	+	16	2198	c.2115G>A	c.(2113-2115)gaG>gaA	p.E705E	MOV10L1_ENST00000540615.1_Silent_p.E685E|MOV10L1_ENST00000395858.3_Silent_p.E705E|MOV10L1_ENST00000545383.1_Silent_p.E705E|MOV10L1_ENST00000395843.1_5'UTR	NM_018995.2	NP_061868.1	Q9BXT6	M10L1_HUMAN	Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse)	705					germ cell development|multicellular organismal development|spermatogenesis		ATP binding|ATP-dependent RNA helicase activity|magnesium ion binding|RNA binding	p.E705D(1)		breast(2)|endometrium(2)|kidney(5)|large_intestine(18)|lung(20)|ovary(3)|prostate(1)|skin(9)|stomach(4)|urinary_tract(3)	67		all_cancers(38;3.31e-11)|all_epithelial(38;5.69e-10)|all_lung(38;3.73e-05)|Breast(42;0.000525)|Lung NSC(38;0.000954)|Ovarian(80;0.0367)|Lung SC(80;0.114)		LUAD - Lung adenocarcinoma(64;0.0215)|BRCA - Breast invasive adenocarcinoma(115;0.24)		GAACAGAGGAGAGGCGTGTTG	0.478000													91	69					0	0	0.003610	0	0
JPH2	57158	broad.mit.edu	37	20	42744361	42744361	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:42744361T>C	ENST00000372980.3	-	4	2826	c.1954A>G	c.(1954-1956)Aag>Gag	p.K652E		NM_020433.4	NP_065166.2	Q9BR39	JPH2_HUMAN	junctophilin 2	652					calcium ion transport into cytosol|regulation of ryanodine-sensitive calcium-release channel activity	integral to membrane|junctional sarcoplasmic reticulum membrane|plasma membrane				NS(1)|endometrium(3)|kidney(1)|large_intestine(5)|liver(1)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	32		Myeloproliferative disorder(115;0.0122)	COAD - Colon adenocarcinoma(18;0.00189)			CGCGCCTTCTTCTTGGCCCCC	0.677000													10	35					0	0	0.000978	0	0
SPNS3	201305	broad.mit.edu	37	17	4352556	4352556	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:4352556G>A	ENST00000355530.2	+	7	1077	c.797G>A	c.(796-798)gGa>gAa	p.G266E	SPNS3_ENST00000576069.1_Intron|SPNS3_ENST00000333476.2_Missense_Mutation_p.G139E	NM_182538.4	NP_872344.3	Q6ZMD2	SPNS3_HUMAN	spinster homolog 3 (Drosophila)	266					lipid transport|transmembrane transport	integral to membrane				NS(1)|endometrium(2)|kidney(3)|large_intestine(5)|lung(7)|ovary(1)|prostate(1)|skin(6)|stomach(2)	28						TCGACCCTCGGAGTGACCGCC	0.657000													25	41					0	0	0.001786	0	0
ATF6B	1388	broad.mit.edu	37	6	32087715	32087715	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:32087715G>A	ENST00000375201.4	-	9	888	c.843C>T	c.(841-843)atC>atT	p.I281I	ATF6B_ENST00000375203.3_Silent_p.I284I			Q99941	ATF6B_HUMAN	activating transcription factor 6 beta	284					response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(11)|prostate(2)|skin(1)|urinary_tract(1)	22						TAGCACCCTGGATGAGGACAA	0.617000													187	531					0	0	0.003610	0	0
EIF4A3	9775	broad.mit.edu	37	17	78120709	78120709	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:78120709G>A	ENST00000269349.3	-	1	273	c.52C>T	c.(52-54)Ctc>Ttc	p.L18F		NM_014740.3	NP_055555.1	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A3	18					mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	10	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			TCCTCTTTGAGCAGCCGCTTT	0.647000													10	23					0	0	0.000673	0	0
OR1S2	219958	broad.mit.edu	37	11	57970829	57970829	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:57970829G>A	ENST00000302592.6	-	1	824	c.825C>T	c.(823-825)ccC>ccT	p.P275P		NM_001004459.1	NP_001004459.1	Q8NGQ3	OR1S2_HUMAN	olfactory receptor, family 1, subfamily S, member 2	275					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(11)|kidney(1)|large_intestine(4)|lung(23)|ovary(2)|skin(2)|stomach(2)|urinary_tract(1)	46		Breast(21;0.0589)				GAGTGGAGGAGGGGAAAAAGT	0.493000													51	48					0	0	0.003610	0	0
VWA2	340706	broad.mit.edu	37	10	116049153	116049153	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr10:116049153G>A	ENST00000603594.1	+	12	2348	c.2027G>A	c.(2026-2028)cGg>cAg	p.R676Q	VWA2_ENST00000392982.3_Missense_Mutation_p.R676Q	NM_001272046.1	NP_001258975.1	Q5GFL6	VWA2_HUMAN	von Willebrand factor A domain containing 2	676	VWFA 3.					extracellular region				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(6)|ovary(2)|prostate(1)|skin(1)|stomach(1)	26				Epithelial(162;0.036)|all cancers(201;0.0793)		GAGGGTCTGCGGAGGCTTGCA	0.622000													7	31					0	0	0.004482	0	0
BRD1	23774	broad.mit.edu	37	22	50216722	50216722	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr22:50216722C>T	ENST00000216267.8	-	1	1730	c.1244G>A	c.(1243-1245)aGc>aAc	p.S415N	BRD1_ENST00000342989.5_5'UTR|BRD1_ENST00000542442.1_Missense_Mutation_p.S54N|BRD1_ENST00000404034.1_Missense_Mutation_p.S415N|BRD1_ENST00000457780.2_Missense_Mutation_p.S415N|BRD1_ENST00000404760.1_Missense_Mutation_p.S415N|BRD1_ENST00000459821.1_5'UTR	NM_014577.1	NP_055392.1	O95696	BRD1_HUMAN	bromodomain containing 1	415					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			endometrium(6)|kidney(3)|large_intestine(5)|lung(17)|ovary(1)|pancreas(1)|prostate(3)|skin(1)	37		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		TTTAACCGAGCTCTCTTTTCG	0.547000													60	213					0	0	0.003610	0	0
CCDC129	223075	broad.mit.edu	37	7	31682335	31682335	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:31682335G>A	ENST00000319386.3	+	11	1900	c.907G>A	c.(907-909)Gga>Aga	p.G303R	CCDC129_ENST00000409210.1_Missense_Mutation_p.G359R|CCDC129_ENST00000407970.3_Missense_Mutation_p.G451R|CCDC129_ENST00000451887.2_Missense_Mutation_p.G477R			Q6ZRS4	CC129_HUMAN	coiled-coil domain containing 129	451										cervix(1)|endometrium(3)|kidney(3)|large_intestine(6)|lung(31)	44						TGCTGAGAATGGAGGTAGAAA	0.512000													17	18					0	0	0.004007	0	0
LY75	4065	broad.mit.edu	37	2	160664965	160664965	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:160664965G>A	ENST00000263636.4	-	33	4844	c.4817C>T	c.(4816-4818)tCt>tTt	p.S1606F	LY75_ENST00000553424.1_Missense_Mutation_p.S1606F|LY75_ENST00000554112.1_Missense_Mutation_p.S1606F|LY75-CD302_ENST00000504764.1_Missense_Mutation_p.S1606F|LY75-CD302_ENST00000505052.1_Missense_Mutation_p.S1606F	NM_002349.3	NP_002340.2			lymphocyte antigen 75											NS(2)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(22)|prostate(7)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	59				COAD - Colon adenocarcinoma(177;0.132)		CTTACCAACAGAATGTTGAGA	0.343000													26	28					0	0	0.006320	0	0
FBXO8	26269	broad.mit.edu	37	4	175184040	175184040	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:175184040G>A	ENST00000393674.2	-	2	1066	c.204C>T	c.(202-204)ttC>ttT	p.F68F	FBXO8_ENST00000503293.1_Intron	NM_012180.2	NP_036312.2	Q9NRD0	FBX8_HUMAN	F-box protein 8	68	F-box.				regulation of ARF protein signal transduction|ubiquitin-dependent protein catabolic process	cytoplasm|ubiquitin ligase complex	ARF guanyl-nucleotide exchange factor activity	p.F68F(1)		breast(3)|endometrium(1)|kidney(1)|large_intestine(5)|lung(2)|prostate(1)|urinary_tract(1)	14		Prostate(90;0.00201)|Melanoma(52;0.012)|Renal(120;0.0183)|all_neural(102;0.0887)|all_hematologic(60;0.107)		all cancers(43;7.29e-18)|Epithelial(43;1.85e-15)|OV - Ovarian serous cystadenocarcinoma(60;5.62e-09)|GBM - Glioblastoma multiforme(59;0.00115)|STAD - Stomach adenocarcinoma(60;0.00299)|LUSC - Lung squamous cell carcinoma(193;0.1)		CCAAATTAATGAATCCTTCCT	0.418000													29	53					0	0	0.007291	0	0
APOBEC2	10930	broad.mit.edu	37	6	41021152	41021152	+	Silent	SNP	G	G	A	rs116667889	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:41021152G>A	ENST00000244669.2	+	1	110	c.66G>A	c.(64-66)gaG>gaA	p.E22E		NM_006789.3	NP_006780.1	Q9Y235	ABEC2_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2	22					DNA demethylation|mRNA processing		cytidine deaminase activity|RNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(1)|lung(3)|prostate(2)|skin(1)	10	Ovarian(28;0.0418)|Colorectal(47;0.196)					AGGATCTGGAGAACCTGGACG	0.592000													21	112					0	0	0.003330	0	0
MACC1	346389	broad.mit.edu	37	7	20198181	20198181	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:20198181G>A	ENST00000400331.5	-	5	2111	c.1803C>T	c.(1801-1803)gtC>gtT	p.V601V	MACC1_ENST00000332878.4_Silent_p.V601V|MACC1_ENST00000589011.1_Silent_p.V601V	NM_182762.3	NP_877439.3	Q6ZN28	MACC1_HUMAN	metastasis associated in colon cancer 1	601	SH3.				positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			endometrium(1)|kidney(1)|large_intestine(15)|lung(12)|ovary(2)|prostate(1)|skin(3)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(1)	39						TACCTCTGAGGACTCCTACAT	0.398000													39	126					0	0	0.007835	0	0
DCAF8L1	139425	broad.mit.edu	37	X	27998711	27998711	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:27998711G>A	ENST00000441525.1	-	1	855	c.741C>T	c.(739-741)ttC>ttT	p.F247F		NM_001017930.1	NP_001017930.1	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	247										NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(24)|ovary(3)|prostate(1)|skin(4)|stomach(1)|urinary_tract(1)	56						AGTTAGGAAAGAACTTAGCCT	0.473000													25	4					0	0	0.001512	0	0
NCOR1	9611	broad.mit.edu	37	17	15961014	15961014	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:15961014G>A	ENST00000268712.3	-	40	6463	c.6206C>T	c.(6205-6207)tCc>tTc	p.S2069F	NCOR1_ENST00000395857.3_Missense_Mutation_p.S653F|NCOR1_ENST00000395851.1_Missense_Mutation_p.S1966F	NM_006311.3	NP_006302.2	O75376	NCOR1_HUMAN	nuclear receptor corepressor 1	2069	ID1 (By similarity).|Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(26)|ovary(1)|prostate(7)|skin(2)|upper_aerodigestive_tract(6)|urinary_tract(10)	107				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		AGTCTGCGAGGAAACTTGATT	0.388000													24	19					0	0	0.003954	0	0
RADIL	55698	broad.mit.edu	37	7	4917288	4917288	+	Missense_Mutation	SNP	C	C	G			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:4917288C>G	ENST00000399583.3	-	2	670	c.483G>C	c.(481-483)aaG>aaC	p.K161N	RADIL_ENST00000536091.1_Missense_Mutation_p.K161N	NM_018059.4	NP_060529.4	Q96JH8	RADIL_HUMAN	Ras association and DIL domains	161	Ras-associating.				cell adhesion|multicellular organismal development|signal transduction		protein binding			NS(1)|biliary_tract(2)|breast(1)|central_nervous_system(3)|endometrium(2)|large_intestine(2)|lung(22)|pancreas(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)|OV - Ovarian serous cystadenocarcinoma(56;7.41e-15)		CGTCCGACCTCTTCCTCAGCT	0.602000													21	297					0	0	0.001216	0	0
KCNC3	3748	broad.mit.edu	37	19	50827173	50827173	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:50827173G>A	ENST00000376959.2	-	2	1200	c.1037C>T	c.(1036-1038)cCc>cTc	p.P346L	KCNC3_ENST00000391818.2_Intron|KCNC3_ENST00000477616.1_Missense_Mutation_p.P346L|KCNC3_ENST00000474951.1_Intron			Q14003	KCNC3_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 3	346					cell death	voltage-gated potassium channel complex	voltage-gated potassium channel activity			endometrium(2)|large_intestine(4)|lung(5)|pancreas(1)|skin(1)	13		all_neural(266;0.057)|Ovarian(192;0.208)		OV - Ovarian serous cystadenocarcinoma(262;0.00283)|GBM - Glioblastoma multiforme(134;0.0181)		GGTCAGGAAGGGCTCCGTCTC	0.587000													9	21					0	0	0.006214	0	0
ABCA12	26154	broad.mit.edu	37	2	215820071	215820071	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:215820071G>A	ENST00000272895.7	-	43	6467	c.6248C>T	c.(6247-6249)tCc>tTc	p.S2083F	ABCA12_ENST00000389661.4_Missense_Mutation_p.S1765F|AC072062.1_ENST00000607412.1_RNA	NM_173076.2	NP_775099.2	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 12	2083					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			NS(3)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(45)|lung(44)|ovary(8)|pancreas(2)|prostate(4)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	139		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		GTACATCCAGGAAAATGTTGC	0.438000													9	12					0	0	0.000673	0	0
OR2M3	127062	broad.mit.edu	37	1	248367286	248367286	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:248367286G>A	ENST00000456743.1	+	1	955	c.917G>A	c.(916-918)gGa>gAa	p.G306E		NM_001004689.1	NP_001004689.1	Q8NG83	OR2M3_HUMAN	olfactory receptor, family 2, subfamily M, member 3	306					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(6)|large_intestine(4)|lung(33)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	50	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			AAGATCTTAGGAAAGGGCAAG	0.418000													14	100					0	0	0.003163	0	0
USH2A	7399	broad.mit.edu	37	1	216258115	216258115	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:216258115C>T	ENST00000366943.2	-	25	5478	c.5092G>A	c.(5092-5094)Gaa>Aaa	p.E1698K	RP11-22M7.2_ENST00000430890.1_RNA|RP11-22M7.2_ENST00000445619.1_RNA|RP11-22M7.2_ENST00000446411.1_RNA|USH2A_ENST00000307340.3_Missense_Mutation_p.E1698K|RP11-22M7.2_ENST00000442606.1_RNA			O75445	USH2A_HUMAN	Usher syndrome 2A (autosomal recessive, mild)	1698	Laminin G-like 1.				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			NS(7)|breast(20)|central_nervous_system(3)|cervix(2)|endometrium(32)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(71)|liver(2)|lung(282)|ovary(25)|pancreas(2)|prostate(12)|skin(22)|stomach(7)|upper_aerodigestive_tract(20)|urinary_tract(3)	527				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTGATTTGTTCTTCAGAACTC	0.423000										HNSCC(13;0.011)			27	82					0	0	0.004656	0	0
KCNA10	3744	broad.mit.edu	37	1	111060402	111060402	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:111060402G>A	ENST00000369771.2	-	1	1395	c.1008C>T	c.(1006-1008)tcC>tcT	p.S336S		NM_005549.2	NP_005540.1	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 10	336						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(13)|lung(13)|ovary(3)|skin(1)|urinary_tract(1)	35		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		GGATGGCCAGGGACATGTTCT	0.542000													37	85					0	0	0.002852	0	0
DDI1	414301	broad.mit.edu	37	11	103907797	103907797	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:103907797C>T	ENST00000302259.3	+	1	490	c.247C>T	c.(247-249)Cgg>Tgg	p.R83W	PDGFD_ENST00000393158.2_Intron|PDGFD_ENST00000302251.5_Intron	NM_001001711.2	NP_001001711.1	Q8WTU0	DDI1_HUMAN	DNA-damage inducible 1 homolog 1 (S. cerevisiae)	83					proteolysis		aspartic-type endopeptidase activity			central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(12)|liver(2)|lung(21)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		TGTGGGACCTCGGGCTCCAGG	0.612000													45	70					0	0	0.003610	0	0
LRRN1	57633	broad.mit.edu	37	3	3887884	3887884	+	Missense_Mutation	SNP	T	T	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:3887884T>C	ENST00000319331.3	+	2	2320	c.1559T>C	c.(1558-1560)cTt>cCt	p.L520P	SUMF1_ENST00000534863.1_Intron	NM_020873.5	NP_065924.3	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1	520						integral to membrane				NS(2)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(9)|prostate(1)|skin(1)|urinary_tract(2)	26				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		AATGGGACCCTTCTGGATGGT	0.438000													22	61					0	0	0.002780	0	0
GPR1	2825	broad.mit.edu	37	2	207041817	207041817	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:207041817C>T	ENST00000407325.2	-	3	517	c.155G>A	c.(154-156)gGa>gAa	p.G52E	GPR1_ENST00000437420.1_Missense_Mutation_p.G52E	NM_001098199.1|NM_001261452.1|NM_001261453.1|NM_001261454.1|NM_001261455.1|NM_005279.3	NP_001091669.1|NP_001248381.1|NP_001248382.1|NP_001248383.1|NP_001248384.1|NP_005270.2	P46091	GPR1_HUMAN	G protein-coupled receptor 1	52						integral to plasma membrane	G-protein coupled receptor activity			breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	18		Lung NSC(271;7.93e-06)|Renal(323;0.000147)|Hepatocellular(293;0.000888)		UCEC - Uterine corpus endometrioid carcinoma (47;0.000241)|Epithelial(149;1.91e-37)|STAD - Stomach adenocarcinoma(1183;0.00178)|Lung(261;0.111)|LUSC - Lung squamous cell carcinoma(261;0.184)		TCCTGGAATTCCCAGAACAAA	0.463000													67	73					0	0	0.003610	0	0
ACSS2	55902	broad.mit.edu	37	20	33462924	33462924	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr20:33462924C>T	ENST00000336325.4	+	1	22	c.22C>T	c.(22-24)Ctt>Ttt	p.L8F		NM_001242393.1	NP_001229322.1	Q9NR19	ACSA_HUMAN	acyl-CoA synthetase short-chain family member 2	0					ethanol oxidation|lipid biosynthetic process|xenobiotic metabolic process	cytosol|nucleus	acetate-CoA ligase activity|ATP binding|protein binding			cervix(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(6)|lung(9)	21					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GTGGGCACTTCTTTGTGGTGA	0.517000													29	107					0	0	0.003755	0	0
COL11A2	1302	broad.mit.edu	37	6	33154559	33154559	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr6:33154559G>A	ENST00000341947.2	-	5	870	c.643C>T	c.(643-645)Cag>Tag	p.Q215*	COL11A2_ENST00000374713.1_Nonsense_Mutation_p.Q215*|COL11A2_ENST00000395197.1_Nonsense_Mutation_p.Q215*|COL11A2_ENST00000374708.4_Nonsense_Mutation_p.Q215*|COL11A2_ENST00000361917.1_Nonsense_Mutation_p.Q215*|COL11A2_ENST00000395194.1_Nonsense_Mutation_p.Q215*|COL11A2_ENST00000357486.1_Nonsense_Mutation_p.Q215*|COL11A2_ENST00000374712.1_Nonsense_Mutation_p.Q215*|COL11A2_ENST00000374714.1_Nonsense_Mutation_p.Q215*	NM_080680.2	NP_542411.2	P13942	COBA2_HUMAN	collagen, type XI, alpha 2	215	Nonhelical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			biliary_tract(1)|breast(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(13)|liver(1)|lung(27)|ovary(5)|prostate(5)|skin(6)	68						TAGGCTGCCTGGACCCCTGGG	0.567000													23	288					0	0	0.004656	0	0
ONECUT2	9480	broad.mit.edu	37	18	55103457	55103457	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:55103457C>T	ENST00000491143.2	+	1	541	c.509C>T	c.(508-510)cCt>cTt	p.P170L		NM_004852.2	NP_004843.2	O95948	ONEC2_HUMAN	one cut homeobox 2	170	Poly-His.				organ morphogenesis	nucleus	sequence-specific DNA binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|lung(4)|ovary(2)|skin(1)	15		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		TTccaccaccctcacccgcac	0.667000													3	5					0	0	0.004672	0	0
CRY1	1407	broad.mit.edu	37	12	107391350	107391350	+	Missense_Mutation	SNP	T	T	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr12:107391350T>A	ENST00000008527.5	-	9	2275	c.1408A>T	c.(1408-1410)Atg>Ttg	p.M470L		NM_004075.3	NP_004066.1	Q16526	CRY1_HUMAN	cryptochrome 1 (photolyase-like)	470	FAD-binding.|Required for inhibition of CLOCK-ARNTL- mediated transcription (By similarity).				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	blue light photoreceptor activity|DNA photolyase activity|double-stranded DNA binding|nucleotide binding|protein binding			NS(2)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(11)|ovary(3)|skin(1)	29						TGGTTCACCATTGGTTTAGGA	0.403000													25	76					0	0	0.005443	0	0
SIPA1L3	23094	broad.mit.edu	37	19	38609982	38609982	+	Silent	SNP	C	C	T	rs61729141	byFrequency	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:38609982C>T	ENST00000222345.6	+	9	2837	c.2328C>T	c.(2326-2328)ttC>ttT	p.F776F		NM_015073.1	NP_055888.1	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like 3	776	Rap-GAP.				regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|lung(22)|ovary(2)|prostate(4)|skin(3)	59			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			CTCCTCCTTTCGGCCCCCCCA	0.522000													57	195					0	0	0.003610	0	0
PCNT	5116	broad.mit.edu	37	21	47831715	47831715	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr21:47831715C>T	ENST00000359568.5	+	28	5835	c.5728C>T	c.(5728-5730)Ctg>Ttg	p.L1910L	PCNT_ENST00000480896.1_3'UTR	NM_006031.5	NP_006022.3	O95613	PCNT_HUMAN	pericentrin	1910					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GCAGCAGCCCCTGGCAGCCGG	0.726000													3	3					0	0	0.000248	0	0
GLI2	2736	broad.mit.edu	37	2	121736031	121736031	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:121736031C>T	ENST00000452319.1	+	10	1450	c.1390C>T	c.(1390-1392)Cac>Tac	p.H464Y	GLI2_ENST00000361492.4_Missense_Mutation_p.H464Y|GLI2_ENST00000314490.11_Missense_Mutation_p.H136Y|GLI2_ENST00000435313.2_3'UTR			P10070	GLI2_HUMAN	GLI family zinc finger 2	464					axon guidance|branching morphogenesis of a tube|cell proliferation|cerebellar cortex morphogenesis|developmental growth|embryonic digestive tract development|epidermal cell differentiation|floor plate formation|heart development|hindgut morphogenesis|kidney development|lung development|negative regulation of transcription from RNA polymerase II promoter|odontogenesis of dentine-containing tooth|osteoblast development|osteoblast differentiation|pituitary gland development|positive regulation of DNA replication|positive regulation of T cell differentiation in thymus|positive regulation of transcription from RNA polymerase II promoter|proximal/distal pattern formation|skeletal system development|smoothened signaling pathway involved in ventral spinal cord interneuron specification|spinal cord ventral commissure morphogenesis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(1)|breast(3)|central_nervous_system(4)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(7)|lung(24)|ovary(8)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	64	Renal(3;0.0496)	Prostate(154;0.0623)				CGAGCACATCCACGGGGAGAA	0.627000													46	73					0	0	0.003610	0	0
GPR108	56927	broad.mit.edu	37	19	6732361	6732361	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:6732361G>A	ENST00000264080.7	-	12	1064	c.1038C>T	c.(1036-1038)atC>atT	p.I346I	GPR108_ENST00000430424.4_Silent_p.I104I	NM_001080452.1	NP_001073921.1	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108	346						integral to membrane				breast(2)|cervix(1)|large_intestine(4)|lung(4)|skin(1)|urinary_tract(1)	13						CAATCAGGGCGATGGTGATGA	0.622000													17	33					0	0	0.007413	0	0
DTNA	1837	broad.mit.edu	37	18	32462040	32462040	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr18:32462040G>A	ENST00000283365.9	+	20	2269	c.1918G>A	c.(1918-1920)Gag>Aag	p.E640K	DTNA_ENST00000601125.1_Missense_Mutation_p.E319K|DTNA_ENST00000591182.1_Missense_Mutation_p.E345K|DTNA_ENST00000590831.2_Missense_Mutation_p.E123K|DTNA_ENST00000269190.7_Missense_Mutation_p.E698K|DTNA_ENST00000399097.3_Missense_Mutation_p.E345K|DTNA_ENST00000598142.1_Missense_Mutation_p.E640K|DTNA_ENST00000269192.7_Missense_Mutation_p.E406K|DTNA_ENST00000598334.1_Missense_Mutation_p.E637K|DTNA_ENST00000595022.1_Missense_Mutation_p.E637K|DTNA_ENST00000556414.3_Missense_Mutation_p.E349K|DTNA_ENST00000399113.3_Missense_Mutation_p.E697K|DTNA_ENST00000399121.5_Missense_Mutation_p.E644K|DTNA_ENST00000444659.1_Missense_Mutation_p.E697K	NM_032975.3	NP_116757.2	Q9Y4J8	DTNA_HUMAN	dystrobrevin, alpha	697					neuromuscular synaptic transmission|signal transduction|striated muscle contraction	cell junction|cytoplasm|synapse	calcium ion binding|protein binding|zinc ion binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(4)|kidney(1)|large_intestine(2)|lung(19)|prostate(1)|upper_aerodigestive_tract(1)	29						CAGGGTTACGGAGGATGCAGA	0.438000													18	24					0	0	0.001523	0	0
CASD1	64921	broad.mit.edu	37	7	94163044	94163044	+	Missense_Mutation	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:94163044G>A	ENST00000297273.4	+	7	845	c.558G>A	c.(556-558)atG>atA	p.M186I		NM_022900.4	NP_075051.4	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1	186						integral to membrane				NS(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(13)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	31	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			AATATAAAATGAACATCACCT	0.328000													19	37					0	0	0.007413	0	0
TPSAB1	7177	broad.mit.edu	37	16	1291250	1291250	+	Missense_Mutation	SNP	C	C	T	rs17841226	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr16:1291250C>T	ENST00000461509.2	+	2	373	c.179C>T	c.(178-180)cCa>cTa	p.P60L	TPSAB1_ENST00000338844.3_Missense_Mutation_p.P53L			P20231	TRYB2_HUMAN	tryptase alpha/beta 1	53	Peptidase S1.				proteolysis	extracellular region	protein binding|serine-type endopeptidase activity			NS(2)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(4)|skin(1)	10		Hepatocellular(780;0.00369)				GTCCACGGCCCATACTGGATG	0.711000													18	24					0	0	0.001523	0	0
PLK3	1263	broad.mit.edu	37	1	45271237	45271237	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:45271237C>T	ENST00000372201.4	+	15	2067	c.1828C>T	c.(1828-1830)Cgt>Tgt	p.R610C	PLK3_ENST00000465443.1_3'UTR	NM_004073.2	NP_004064.2	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	610	POLO box 2.					membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.155)					GGCCCGAAATCGTAGTGCTTG	0.602000													45	80					0	0	0.001951	0	0
CATSPERB	79820	broad.mit.edu	37	14	92076893	92076893	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:92076893G>A	ENST00000256343.3	-	21	2685	c.2529C>T	c.(2527-2529)atC>atT	p.I843I		NM_024764.2	NP_079040.2	Q9H7T0	CTSRB_HUMAN	catsper channel auxiliary subunit beta	843					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				NS(1)|breast(4)|central_nervous_system(1)|kidney(3)|large_intestine(15)|liver(1)|lung(12)|ovary(2)|pancreas(1)|prostate(3)|skin(9)|urinary_tract(2)	54		all_cancers(154;0.0663)|all_epithelial(191;0.236)				CTTCAAATGGGATAAATTTGC	0.378000													26	35					0	0	0.004656	0	0
SFMBT1	51460	broad.mit.edu	37	3	52955764	52955764	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr3:52955764G>A	ENST00000394752.3	-	11	1597	c.1215C>T	c.(1213-1215)acC>acT	p.T405T	SFMBT1_ENST00000394750.1_Silent_p.T405T|SFMBT1_ENST00000296295.6_Silent_p.T405T|SFMBT1_ENST00000358080.2_Silent_p.T405T	NM_016329.3	NP_057413.2	Q9UHJ3	SMBT1_HUMAN	Scm-like with four mbt domains 1	405					regulation of transcription, DNA-dependent	nucleus				breast(2)|endometrium(3)|kidney(3)|large_intestine(8)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	24				BRCA - Breast invasive adenocarcinoma(193;9.91e-05)|Kidney(197;0.000644)|KIRC - Kidney renal clear cell carcinoma(197;0.000792)|OV - Ovarian serous cystadenocarcinoma(275;0.113)		CTGCAGTGATGGTAGCAACAC	0.488000													60	161					0	0	0.003610	0	0
DHX34	9704	broad.mit.edu	37	19	47884495	47884495	+	Missense_Mutation	SNP	A	A	C			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr19:47884495A>C	ENST00000328771.4	+	16	3561	c.3212A>C	c.(3211-3213)cAc>cCc	p.H1071P		NM_014681.5	NP_055496.2	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	1071						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(8)|ovary(5)|prostate(5)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		ACCTGCCCCCACTGTGGCCTG	0.667000													17	23					0	0	0.006122	0	0
NALCN	259232	broad.mit.edu	37	13	101890118	101890118	+	Silent	SNP	G	G	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr13:101890118G>A	ENST00000251127.6	-	12	1503	c.1422C>T	c.(1420-1422)ttC>ttT	p.F474F	NALCN_ENST00000470333.1_5'UTR|NALCN_ENST00000376196.3_Silent_p.F474F	NM_052867.2	NP_443099.1	Q8IZF0	NALCN_HUMAN	sodium leak channel, non-selective	474						integral to membrane	sodium channel activity|voltage-gated ion channel activity			NS(1)|autonomic_ganglia(2)|breast(6)|central_nervous_system(2)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(33)|liver(2)|lung(81)|ovary(8)|pancreas(3)|prostate(5)|skin(6)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	177	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GAAAGTACGTGAATTGTGAAT	0.303000													87	113					0	0	0.003610	0	0
MED8	112950	broad.mit.edu	37	1	43850172	43850172	+	Silent	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:43850172C>T	ENST00000290663.6	-	8	898	c.855G>A	c.(853-855)aaG>aaA	p.K285K	MED8_ENST00000372457.4_3'UTR	NM_052877.3	NP_443109.2	Q96G25	MED8_HUMAN	mediator complex subunit 8	0					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				endometrium(2)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)	9	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCAGAAGCTTCTTCACCTTGC	0.517000													6	21					0	0	0.003080	0	0
C1orf94	84970	broad.mit.edu	37	1	34677988	34677988	+	Missense_Mutation	SNP	C	C	T			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:34677988C>T	ENST00000488417.1	+	6	1822	c.1702C>T	c.(1702-1704)Ctc>Ttc	p.L568F	C1orf94_ENST00000373374.3_Missense_Mutation_p.L378F	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	378							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				ACCGCAGTACCTCTTTCCCCA	0.577000													9	16					0	0	0.004482	0	0
PIK3CD	5293	broad.mit.edu	37	1	9770521	9770526	+	In_Frame_Del	DEL	CTGGGG	CTGGGG	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:9770521_9770526delCTGGGG	ENST00000536656.1	+	3	216_221	c.8_13delCTGGGG	c.(7-15)ctg>c	p.PGV3del	PIK3CD_ENST00000377346.4_In_Frame_Del_p.PGV3del|PIK3CD_ENST00000361110.2_In_Frame_Del_p.PGV3del			O00329	PK3CD_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta	3					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(12)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	31	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		AGGATGCCCCCTGGGGTGGACTGCCC	0.529													20	128	---	---	---	---					
C1QC	714	broad.mit.edu	37	1	22973763	22973763	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:22973763delG	ENST00000374639.3	+	3	343	c.225delG	c.(223-225)aafs	p.K75fs	C1QC_ENST00000374637.1_Frame_Shift_Del_p.K75fs|C1QC_ENST00000374640.4_Frame_Shift_Del_p.K75fs	NM_001114101.1	NP_001107573.1	P02747	C1QC_HUMAN	complement component 1, q subcomponent, C chain	75	Collagen-like.				complement activation, classical pathway|innate immune response|negative regulation of granulocyte differentiation|negative regulation of macrophage differentiation	collagen				endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	15		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00262)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;6.21e-27)|Colorectal(126;1.5e-07)|COAD - Colon adenocarcinoma(152;1.12e-05)|GBM - Glioblastoma multiforme(114;1.61e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000538)|KIRC - Kidney renal clear cell carcinoma(1967;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.196)	Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	AAGGGCAGAAGGGAGAACCCG	0.647													12	34	---	---	---	---					
LOC100129620	100129620	broad.mit.edu	37	1	99474094	99474094	+	RNA	DEL	A	A	-	rs57656522		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr1:99474094delA	ENST00000425113.1	+	0	370					NR_033940.1																						AACAGCAACTAAAAAAAAAAA	0.353													3	6	---	---	---	---					
LRRTM1	347730	broad.mit.edu	37	2	80529507	80529518	+	In_Frame_Del	DEL	TCTGATGCATGG	TCTGATGCATGG	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr2:80529507_80529518delTCTGATGCATGG	ENST00000295057.3	-	2	2083_2094	c.1427_1438delCCATGCATCAGA	c.(1426-1440)atg>a	p.TMHQM476del	CTNNA2_ENST00000361291.4_Intron|CTNNA2_ENST00000402739.4_Intron|CTNNA2_ENST00000496558.1_Intron|CTNNA2_ENST00000540488.1_Intron|LRRTM1_ENST00000409148.1_In_Frame_Del_p.TMHQM476del|CTNNA2_ENST00000541047.1_Intron|CTNNA2_ENST00000466387.1_Intron	NM_178839.4	NP_849161.2	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	476						axon|endoplasmic reticulum membrane|growth cone|integral to membrane				NS(1)|breast(1)|endometrium(5)|large_intestine(7)|liver(1)|lung(33)|ovary(3)|pancreas(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(5)|urinary_tract(2)	63						ATGGCAGCCATCTGATGCATGGTCTGTTTCTG	0.538										HNSCC(69;0.2)			15	30	---	---	---	---					
HERC3	8916	broad.mit.edu	37	4	89601295	89601295	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:89601295delT	ENST00000402738.1	+	20	2487	c.2248delT	c.(2248-2250)ttfs	p.F751fs	HERC3_ENST00000264345.3_Frame_Shift_Del_p.F751fs|HERC3_ENST00000543130.1_Frame_Shift_Del_p.F195fs	NM_001271602.1|NM_014606.1	NP_001258531.1|NP_055421.1	Q15034	HERC3_HUMAN	HECT and RLD domain containing E3 ubiquitin protein ligase 3	751					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(10)|lung(14)|prostate(2)|skin(2)	45				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		TACAAAGGAATTTTTTCTTTT	0.343													22	24	---	---	---	---					
ADH1C	126	broad.mit.edu	37	4	100261040	100261041	+	RNA	INS	-	-	A	rs138827617	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr4:100261040_100261041insA	ENST00000515683.1	-	0	1316					NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	AGTGCTTTCACAAAAAAAATCA	0.327													6	1	---	---	---	---					
ZFR	51663	broad.mit.edu	37	5	32419951	32419953	+	In_Frame_Del	DEL	GGT	GGT	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:32419951_32419953delGGT	ENST00000265069.8	-	3	495_497	c.393_395delACC	c.(391-396)ccc>cc	p.PP131del		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	131	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		AGTAGCTGGGGGTGGTGGTGGTG	0.483													7	218	---	---	---	---					
MAPK9	5601	broad.mit.edu	37	5	179665329	179665349	+	Splice_Site	DEL	AACCTGAAGGCTGATCTTTTA	AACCTGAAGGCTGATCTTTTA	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr5:179665329_179665349delAACCTGAAGGCTGATCTTTTA	ENST00000452135.2	-	11	1413_1431	c.1132_splice	c.e11+1	p.372_splice	MAPK9_ENST00000393360.3_Splice_Site_p.372_splice|MAPK9_ENST00000343111.6_Splice_Site_p.372_splice|MAPK9_ENST00000347470.4_Splice_Site_p.287_splice|MAPK9_ENST00000455781.1_Splice_Site_p.372_splice|MAPK9_ENST00000397072.3_3'UTR			P45984	MK09_HUMAN	mitogen-activated protein kinase 9	372					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding			central_nervous_system(2)|endometrium(5)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	26	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AGCAATCACTAACCTGAAGGCTGATCTTTTACAACACCATT	0.344													9	154	---	---	---	---					
OR6W1P	89883	broad.mit.edu	37	7	142759847	142759847	+	RNA	DEL	A	A	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr7:142759847delA	ENST00000496192.1	-	0	679					NR_002140.1															central_nervous_system(1)|endometrium(2)|lung(1)|skin(1)	5						CCAGAGGAGGAAGGGATGTGC	0.567													2	4	---	---	---	---					
HR	55806	broad.mit.edu	37	8	21978407	21978407	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr8:21978407delT	ENST00000381418.4	-	11	3912	c.2432delA	c.(2431-2433)ggfs	p.E811fs	HR_ENST00000312841.8_Frame_Shift_Del_p.E811fs	NM_005144.4	NP_005135.2	O43593	HAIR_HUMAN	hair growth associated	811							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CAGGGCTTTCTCCTGGATCTT	0.677													2	4	---	---	---	---					
MIRLET7DHG	158257	broad.mit.edu	37	9	96941099	96941100	+	RNA	INS	-	-	A			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:96941099_96941100insA	ENST00000416309.2	-	0	164				RP11-2B6.3_ENST00000602703.1_lincRNA	NR_046163.1																						AGACCAGCAAGAAAAAAAAAAT	0.376													4	8	---	---	---	---					
CIZ1	25792	broad.mit.edu	37	9	130953109	130953111	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr9:130953109_130953111delGCT	ENST00000538431.1	-	2	273_275	c.26_28delAGC	c.(25-30)ctc>c	p.QL9del	CIZ1_ENST00000372948.3_In_Frame_Del_p.QL9del|CIZ1_ENST00000357558.5_In_Frame_Del_p.QL9del|CIZ1_ENST00000325721.8_In_Frame_Del_p.QL9del|CIZ1_ENST00000277465.4_In_Frame_Del_p.QL9del|CIZ1_ENST00000393608.1_In_Frame_Del_p.QL9del|CIZ1_ENST00000372938.5_In_Frame_Del_p.QL9del|CIZ1_ENST00000541172.1_5'UTR|CIZ1_ENST00000372954.1_In_Frame_Del_p.QL9del|CIZ1_ENST00000476727.2_5'UTR	NM_001257975.1	NP_001244904.1	Q9ULV3	CIZ1_HUMAN	CDKN1A interacting zinc finger protein 1	9	Gln-rich.			Missing (in Ref. 7; AAF23231).		nucleus	nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|liver(1)|lung(9)|ovary(3)|prostate(2)|urinary_tract(2)	35						tgttgctggagctgctgctgctg	0.611													3	5	---	---	---	---					
BSCL2	26580	broad.mit.edu	37	11	62474622	62474633	+	In_Frame_Del	DEL	CTTTTTCCCCAG	CTTTTTCCCCAG	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr11:62474622_62474633delCTTTTTCCCCAG	ENST00000433053.1	-	2	591_602	c.35_46delCTGGGGAAAAAG	c.(34-48)gag>g	p.AGEKE12del	BSCL2_ENST00000405837.1_In_Frame_Del_p.AGEKE12del|RP11-831H9.16_ENST00000403734.2_3'UTR|BSCL2_ENST00000360796.5_In_Frame_Del_p.AGEKE12del			Q96G97	BSCL2_HUMAN	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	336					cell death	integral to endoplasmic reticulum membrane				endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|prostate(1)|skin(1)	12						CCGCACACCTCTTTTTCCCCAGCTTCCTCCTT	0.514													46	324	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20087717	20087731	+	RNA	DEL	AAGCTGGGGCTTCCA	AAGCTGGGGCTTCCA	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:20087717_20087731delAAGCTGGGGCTTCCA	ENST00000548261.1	+	0	195_209																											ATTTTCTACCAAGCTGGGGCTTCCAAAGCTGGGAA	0.377													4	6	---	---	---	---					
IL25	64806	broad.mit.edu	37	14	23845057	23845058	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:23845057_23845058delTG	ENST00000329715.2	+	2	760_761	c.502_503delTG	c.(502-504)tfs	p.C168fs	IL25_ENST00000397242.2_Frame_Shift_Del_p.C152fs	NM_022789.3	NP_073626.1	Q9H293	IL25_HUMAN	interleukin 25	168					inflammatory response	extracellular space|membrane	cytokine activity|interleukin-17E receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	9	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.00665)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0396)		TTCCTTAGCTTGTGTGTGTGTG	0.604													7	69	---	---	---	---					
ADAM21	8747	broad.mit.edu	37	14	70924869	70924871	+	In_Frame_Del	DEL	ATG	ATG	-	rs141326765		TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr14:70924869_70924871delATG	ENST00000603540.1	+	2	911_913	c.653_655delATG	c.(652-657)cat>c	p.HD218del	RP11-486O13.4_ENST00000556646.1_lincRNA|ADAM21_ENST00000267499.3_In_Frame_Del_p.HD218del	NM_003813.3	NP_003804.2	Q9UKJ8	ADA21_HUMAN	ADAM metallopeptidase domain 21	218	Peptidase M12B.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(10)|lung(10)|pancreas(1)|prostate(1)|skin(2)|stomach(1)	31				all cancers(60;0.00326)|BRCA - Breast invasive adenocarcinoma(234;0.00646)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GTGGTGAACCATGATTTCTTCAT	0.414													8	43	---	---	---	---					
RP11-160E2.17	0	broad.mit.edu	37	17	18988562	18988562	+	RNA	DEL	T	T	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:18988562delT	ENST00000442355.2	+	0	272																											CTGATGTGTGTTTTTTTTTTT	0.279													2	4	---	---	---	---					
CCDC40	55036	broad.mit.edu	37	17	78055757	78055757	+	Frame_Shift_Del	DEL	C	C	-	rs61749058	by1000genomes	TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chr17:78055757delC	ENST00000397545.4	+	12	1916	c.1889delC	c.(1888-1890)gtfs	p.A631fs	CCDC40_ENST00000374877.3_Frame_Shift_Del_p.A631fs	NM_017950.3	NP_060420.2	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	631					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(7)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(1)|urinary_tract(1)	38	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AAGACGGATGCTGCCATCCGG	0.562													10	27	---	---	---	---					
NRK	203447	broad.mit.edu	37	X	105137893	105137893	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FS-A1ZK-06A-11D-A197-08	TCGA-FS-A1ZK-10A-01D-A199-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	41a7b031-d928-4a1f-891b-82fb3f6d548f	8bb3517f-9e54-4272-a6c2-a7b8e8cc567d	g.chrX:105137893delA	ENST00000428173.2	+	6	750	c.447delA	c.(445-447)ttfs	p.L149fs	NRK_ENST00000536164.1_Frame_Shift_Del_p.L149fs|NRK_ENST00000243300.9_Frame_Shift_Del_p.L149fs			Q7Z2Y5	NRK_HUMAN	Nik related kinase	149	Protein kinase.						ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(8)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(14)|lung(36)|ovary(3)|prostate(1)|skin(2)	76						ATCAGAGTTTAAAAGAAGATT	0.383										HNSCC(51;0.14)			18	4	---	---	---	---					
